@rCer/1/1823_55_CCS ATGGGACCGCCGAGACCGCGTCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAAGCTCGGCATGTGCAAGGCCGGCTTCGCGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACGCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCGATGGCCAGGTATCACCATGGCAACGAGCGGTTCCGCTGCCCTGAGCTCTCTTCCAACCTTCCTTCCTGGCATGGAGTCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACATGTACCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCTTGCCTCCTAAAAGCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAATTATGTAATGCAAAATTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + -,12$#),45+./221&0*0*#/,40,5/02502644))4155-.052,00)1//0.0#5/.03&-3(/3/334224/0-&/++),..)+%3.32*011+,-)'/1--.+&+/+0(.+,0/0+#%.-$''1-1.,0-0/0&1)-%./0/'&%#*'+),('(-).0%%.&,&/.'0++.,%)(&)11.1/,+%-),,,#/2//'&%++/%,11-00-,+--'-1.,1//&),2.--+',+*(%,$'.).,*(*,0-/.)*1.1-,-/./-/&10-&+(,-/-+/-.'10,+-+&11,-/0+/*,%(++0.10/-$0),,..+1110,111-1..-*11010,/-1,*-,200111*01*111...0,/(/1210---0.11.1011220,.,)+.(//.-+#$0.1*.*,,%./1+11.,0+200*0/,(1-+,-2100-0-11,.1.11-,000)0.100,/01010+(++&+,/+0--0+++.+%2--*-*,)%0/0//1--,,,'*+.+*1.*-000-/10,,+(&'00%+,+//,)1,,(,&10,..01-),,#*.-221+-/0+/'-021.-0,-+,0.-1*11*/01,.--11)-*./,*0/0,/-/110/&./&02-*00&20//%*2/11010/'0112/././)/$..12.).+/1..11-//+01...111....+/2/*+1+1.1*0,00,01(1,.010.11*+&1,0.,+001-11.0/.1+01111-01,.,0-+..10.+..20+-/,0.-'0.-,0/+(+*,-/+,/-//0)1010-1,0.,0/01-*%01/0&+.-1./&020$,0/,/'*',*0++&/.-1200++(/,*,2-/'-+$.-/,0200.2-,*1-200.0,//%*10/,.)'#(/*1-,.-1--110,*0-00-21121111(.010-12,,-/00.(00..%(,'0-.111,,01,)+*,0-/.2,11110*,*010,**+--(/*1*%%010+-/$/2001.011,)(&,2-110,012/-++&+,*1101.%/201002-)-/)(,..-0.01.12./%/,1211111)-),,1000,0'-11,10,-,/110/*(-2012.0-21-,*)'-+-)+&0--),.)124303.3*/,-/.4/4-35646660.536-41344/.4432560411(6/1+510/*504314/35,5656362560-63664665406.4-100210-41104)51*/5+522545+10-3)33'1554622-1+565231540,655)2660006655631+555444$)455-'052,-+4544443-#-031114./4/20.1%+154,//1.232-+.16361641/24415104.2162'545410/1301&06-23/4.56121133(2)-24+/26524)0*1.23.0*35.//.0/11/&614/52211532552./+05026654512315533'32014'0.44'.2-1530.2#)1240.03*02333.2/3.10.*33166/51/6033210-*+(.0.//0/)341'.2/0,+045211+5511)/402/5%/012136/&1*,03&24543&64+02/0+306.6000045563*,213(.0//$-/31*//(.320565405*40345443##(.121)-.2+.0)311+-1*154/+-%31500432+2.3+014+166105546-/1006200/-*.51-)6+40*,-/264664156/2555612.625621355(54522./.() @rCer/3/2341_60_CCS ATGGGGACTGCAGCACTAGCCGTCTGCAGCTCCGGCCGCCACTCGCGCCTCTCCAGCCTCTGCAGGCCCAAACGCCACCAGCACCATGGCCAGCACCATTTCGGCTTACAAGGAGAAGATGAAGGAGCTGTCGGTGCTGTCACTCATCTGCTCCTGCTTCTACACACAGCCGCACCCCAACACCATCTACCAGTATGGGGACATGGAGGTGAAGCAGCTGGACAAGCGGGCCTCTGGCCAGAGCTTCGAGGTCATCCTCAAGTCCCCTTCTGACCTGTCCCCAGAGAGCCCTATGCTCTCCTCTCCACCCAAGAAGAAGGACACCTCCCTGGAGGAGCTGCAAAAGCGGCTGGAGGCAGCTGAGGAGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACAACAACTTCAGCCGGCAGGCGGAGGAGAAGCTCAACTACAAGATGGAGCTCAGCAAGGAGATCCGCGAGGCGCACCTGGCCGCACTGCGCGAGCGGCTGCGCGAGAAGGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGGAGATGTCGGGCTAAGGGCCCGGGACGGGCGGCGCCCATCCTGCGACAGAACACGTTCGGGTTTCGGTTTTGTTTCGTTCACTCTCTGTCTAGAGAATCAAAAAAAATGCAACTTTTGTTCCTCCTCCCCCACCCACGCCCCAGCTTCATGCTTCTCTTCTGCACTCAGCCGCCCCGCCCTGTCCTCGTGGTGAGTCGCTGACCACGGCTTCCCCTGCAGGAGCCGCCGGGCGTGAGACGCGGTCCCTCGGTGCAGACACCAGGCCGGGCGAGGCTGGGTCCCCCGGGGGCCTTGTGAGAGAGGTGGTGGTGACCGTGGTAACCACAGGGCGGTGGCGTGGGATCGCGGGTCCTTACACTGGGCTGTCTGGTCAGCATGTGCAGGTCAGGGCAGGTCCTCTGAGCCGGCGCCCCTGGCCAACAGGCGAGGCTAGGGTACCTGCTGTCTTTCCAAGGGGAAGGGGCTCCCCATGCGGGAGGGGCAACGGGGGAGGGGGGGGGTGATGGTGCCTGGGAGCCTGCGTGTTAAGCGGGAGCTTGTTTGAACTGGCAGGCAGGTGGGTGGGGGCTGCAGCTCTCCTTAATGTGGTTGCACAGGGGTCCTCTGAGACCACCTGGCCTGAGGTGGACACCCTGGGCCTTCCTGGAAGCCTGCAGTTGGCGGCCTGCCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCCAGGGGCCCATGAGCAGGCTGCCGTGGTCTAGAGGTTGTGGGCAGCATGGACAGTCCCCCACTCAGCAGTGCAAGAGTTCCAAAGAGCCTCTGGCCCAGGCGCCTCGGTGAGACAGCCCCGCCGCCCTCCCCACCAGGGCTTTGCGGATGTCCTTGAAAGACCCGGCCTAGAGCCCTTTGGAGTGCTGGCCCCTCCTGTGCCCTCTGCCCTGGTGGAAGTGGCAGCCACAAGTCCTCCTCAGGGAGCCCTGAGGGGGATTTTGTGGGACTGCTGCCCACAGATCCAGGGTTGGAAGGGCAGCGGGTAAGGTTCACAAGCCACCCCCACACCCTTCCCACTCGGCACCCAGAGGGGCTGTGGGTCGAGGCCTGACTCCAGGCCTCTCCTGCCCACACCTTCTGGGCTGGGTTCCTTCTCTCCCTTGGATGCCCAGTGCTGGCCTTGGAGGACGGTCATCTGGAGGACGGGGGTGGGGGAGGCTGTCTTTGTACCACTGCAGCATCCCCCACTTCCCCACAGAAGCCCCATCCCAAAGCTGCTGCCTGGCCCATTGCTGTAAAATGTGAAGGGGGCAGCTGAGTTCTCTTAGGACCCAGAGCCAGGGCCCTCAGCTTCCATCCTGCGGGAGGCCTTGGGCAGGCACTGCCAGCGTCTTCCAGGGCCACACCAGGGACTATGGGAGGATCCTGACCCCTGCAGGGCTCAGGGGTCAGCAGGGACCCACTGCCCCGTCTCCCTCTCCCCACCGAGACAGCCCCAGAGGGAGCAGCCAGCTGGGATGGGAACCCAAGGCTGCCCACATGTGGCTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGGCTGGGATTCTCCTCACGGTGGCAGCTCTCATAGCGAAAGCCTAGTGTAATATGCACCCATCTCATCCACGTAGTAAAGTGAACTTAAAAATTAAATCAAATGAACAATAAACACCTGTGTGTTT + =>??<8685>7*29;99>=78::3176;29<:8;839;677>?<>?4<>0==3<0=4:<57705=72/=<72;=455268?9>900914:;2=5?;@40<77;;:888:8>>A==>7<<5?4;,9@9<<>??@>B==<8<4:<598=6;98=BA:<3=7<<=?AA>A=3/&?8?9<-<@;@>;?A2<47??=ABB;=>87:85>=AB9A@A=75A;?:?A;4A6<;<5>;?CC;@?>=?@A57@@@A754<7>>?=>9@;4;=<::1-=8=1-<:?2<3<;<@C8?7;>4B:,=B9@?=;=55>?;:48==0==B226C>=?+@<9563326:?A0<9:0/=A;@8;89*2462948:;/3'4;:;>8<-486:7@<7/<.9:921,2'21;=586=56:7<6=67<2><<:;(?=3=;<9.8<8<9<7?A8=<==>>>=;=>>>3':57::/3/<35-67864;8;@=:)<;9749<58;5.57<563725<<39=7B@>6:A3@@4>?;9;7?2==5;5C=7B8;85>B<779B?6;<;8;299-1;8(;B>494'4:=4=5.(1*##)%)(*...'&('*#%')(*,,,%#,37:3:75.$/53741773.471*1+2).$//.3&7;8CAA76A;>;@>2;066B>7<<8<:93;;>8+87:4>B47->5876/5-85;?9@>@/56@B@?;:821<7=.65*70::4?3/6.<=;0:<=9A9-6077>469=7A2<:+9-:9909/>;<=4833+6129265;926>496<:>9/6>3>5:=@<78;9??4;702;06;=7;+=7-1)088<99:9AA:=7>9,>8@:;7C<<307=:358;885713;8;%67;99C9:;849376@<:>:0,+43%;=A661--/*&2*058075=<=75B=3A@;==07@C@88//26,3;84=B<;8<59*<3429A;8,:3<98568:040.73+1;?6=@=<8;==A?@>7:6:17%28183:98.,;;>B96:64=03?-&9276595;79@;::978257?8A5A7<4=759:=?=2=;3;;1,1286003312(2?A>;:4=69-67/036>:1663'/7963:473/;'298@9@C:=7>73=818/3,+*2013$.544<>?<6<>2135%4+>42410*881911,+<8;7CACA5@;7:+8<8=8=<4704>=;<;739-;BA:@<=7:<7=B?A?=)060:*8;4-:?;===,:7=8<;89>9=*+6717-;=2;9:598BA:?.=8:=8<<84=<.<5:19:;?A7>C6.:94?1;;><28743+8@4:<87ABB:;=:<@;>?=CCCC0;?>9/>;88/6@8:7<@=:5:8,;8<=/@CA:A>B8@:;?246>=89(;80>8A;:B?>8>2A=392.>9487<76:;:<::&)=?A6?3;A=;=7>36BCC>C>;@>=;CA;?2<<770;8:@9A3<:=:+949=3@?C::6747.;=1=76.,>>>:.4=B85%8?<95;<>;?-5?@A0A:>B.9*4>8@C637:8=B@@B?>5?<7:;4>?AA2>7?@<<=@?2@>><.;;?A>A?;6AAB=>A?9?@0;;6;5>:C@C=A7=;:;<21>1=,68><5;?>*@;B::8-:=>953-&;,:A?.@:;<=?86:B69:/7=@@/>A4>5<3<==?=?<+=;<=><>348=:9/6B?>6??>*/7046>29<9<0=<:243-.%1+09/689@>A?<4:7=958.,:=*<864<=867<=CC99:;>/C=>@8>7=78/<>97782)4;?7497%154:*5=>?;75:.48.?91536416;4-35(<>:4+3:5921,+,24+27<5<9680696031,<98:/45.6,1.-00-23542296202385798/;;61.66:507360.0=:;=8-*5%05.<;68)9>78233613-3275=<:75276. @rCer/5/2043_56_CCS ATGGGTAGACTGGGTCAAAGCTTATTTAAGTATATGGACAGAGCTGCAGGCTTACATTAAGGAGTTCCATACCACCGGACTGGCCTGGAGCAAAACGGGGCCTGTGGCAAAGAACTGAGTGGACTGCCATCTGGACCCTCTGCTGGATCAGGTCCTCCTCCCCCTCCGCCAGGCCCCCCTCCTCCCCCAGTCTCTACCAGTTCAGGCTCAGATGAGTCCGCTTCCCGCTCAGCACTGTTTGCGCAAATTAATCAGGGGAGAGCATCACACATGCCCTGAAGCACGTATCTGATGACATGAAGACTCACAAGAACCCTGCCCTGAAGGCTCAGAGTGGTCCAGTACGCAGTGGCCCCAAGCCATTCTCTGCACCTAAACCCCAAACCAGCCCGTCCCCCAAACCAGCCACAAAGAAGGAGCCAGCTGTACTTGAACTGGAGGGCAAGAAATGGAGAGTGGAAAATCAGGAAAATGTTTCCAACCTGGTGATTGATGACACAGAGCTGAAACAGGTGGCTTACATATACAAGTGTGTCAACACGACATTGCAAATCAAGGGCAAAATTAACTCCATTACAGTAGATAACTGTAAGAAACTTGGTCTGGTATTCGATGACGTGGTGGCATTGTGGAGATAATCAACAGTAGGGATGTCAAAGTTCAGGTAATGGGTAAAGTGCCAACCATATCCATCAACAAAACAGATGGCTGCCATGCTTACCTGAGCAAGAATTCCCTGGATTGTGAAATAGTCAGTGCCAAATCTTCCGAGATGAATGTCCTCATTCCTACAGAAGGCGGTGACTTTAATGAATTCCCAGTTCCTGAGCAGTTCAAGACCCTCTGGAATGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAAGCGAAGTGCCACTGGGTTCTTTGCCCTCCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTTCTAGATTTCCTCTACCTTTCTGCTCTTAAAACTGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTGGGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGACTGATGATGCATTTTAGCTTTGAGCTTTTGGGGGTTATTCTACCAACAAACAAACAGTCCATTGGAAAGAAAACAGTCCCAGGAATTAACAGATCAGAATGTTCACACTGGTTAATCTTTTTCTAACAGTGAGCATGAAGGTAGCAGAAGCTGGTGTGTTTCCAGATGGTTCTTCTAACCAAACTAATTTTCACTGTTGACAAGTGAGGCAAGGGTTGCACTGGACCGAAGGCTGAGGCTTGGCCATCTAGCATTCCATGCAGAATGGTTTCCCATAAGCATTCCTTTTATTCTCTGTTCTATCCTGGGTCTGCCTCAACCATGAGATAGGAGAGTCTCCGGTACTAGCTGCTATCCAGGGCAGTTAATGGAGTCTTGAACCCTTTCTTTCTCTGGGATCCCTGACTAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAGGAAAAACAACACACCATTTCAAGGAGTCTGGCATTCCTGAATCCTCCTTCCCTGCTAGGTGCCTGTCACCTGTCTTCACTGCCTGCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCCAAGCACCTGAACAGAGGACTAAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGATTTATGTAAGAATCTTGCACAGCACTGCTAATGTAAATTTCAGTTTTTCCCCTCTAGGACAAACACTTACCAAAATATGCAACTTTTTTTTGGTGGGAAGAGAGATTGTCCTGTGATTTCTACCCATTTCCTGAGGCCTGTGGAAATAAACCTTTATGTACTTAAAGTTATACAGAAAATAGAATAAAGTTAATAC + DGEG*9BKJ?GGI/CHIJ+IJKEKKK4H>JFGIJFKCJHKFGJKCHKJKIKK?KKHFEKFK9GAJDFFIHGKEFJCHHHKFKCHIIHKIAJIJHIDGHFHFGCDF?KK?FI:KKK;I0>KGFJHDDIBHIEICHGH6KKF5HK;KHIGGD;GCDHKF9KJAAIJEHHHKG7HJGD4JHJEKJHIDFHIJDG:CHKFFIJJKIIIKKK@EFJFEKCDFHDKGDIEJIDAAEB@ACHK;JJIHJIJKIG8;%;H;GBG=GII4EHFG8G5JGFCCFJCIFIID;GHH8IHE>CJ:EAFFII.JJ=HHIBG?DA=:=DJHGIIJEFFBE7J6C9GEEF9B;>J@AF@EDG:IFBHHBE;IH?FHF=F9IIJG+>HHIEECEGF4GHAD@?C5F8EEDIG5GEGFHIGHFGI=G;GAFH>IHJFGHIGBHFHJEIGFFHF-;>JJ>FFGIIFCHH?FHBHAG>EGIHAEGDI@FC3D:GCF9FABD?EHBC9CH;DGB0G?GGD6C@E?EDDFCHGAJIGGHFEHGCHEHGI/I>C=IHHFGDGHE@FADFDJIHJGGF?F:CICCHFE@CGFC@8F9DI6EF?E>DBGDHG6AI=?GF=J@DHIEEIICJG:FHHI?;DC8:@IIHEEDA=GE;EDCF95=D5H3ECD@EA9?BE=AFFDG?9B8?B+D?DCA?DG:9E?FE85%79CFGC@@?CDFEE7F@ECA>EGCECF?@=C;>D@CDFBD@F?B@?F6A;>C:AE>7E8AF>>C,CG@FEGC7DD97FBBE?E@A5@CB=FDBE?EADCC0AED/FDE?@AC@BDEC:?@)5.>C?=*<;965=3:0?>D5BE7BBECECAF?EADAE@ECG;EB9@A?F;GGCEECCBG=CCB+@EC;ACBC?@?E>EDF@AFEAE;BGA?DC4AFB>EF?:FDE;5>EEE@AD@FEFE@AFFF8EAGEADEC>GFEG?B>A8FDFGCCEE?CFC@D7;AEE<7CCB&BE>AE4?>B@=?A6GCDA?GFE=>9<>EF;?BFFDFE>)65>=G9A7>DC@ABE@?EF>@ADB1>6>BD1CCE6ABFA2E=@:;>C?9EGB@BE4E?F>3AB@DFEE4ED9D;>DCAEGCC;@3BA:FE9FE-?E8FA;58 @rCer/6/24_1545_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGTTTAACTGTCTCTTACTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTT + @B%AEF2E1=EB47CGE=6DAJDFJB@9FGADC4HH4G2>GGC9EDD;A?B5@;C207H>1HFHBI/FJEHFEGF7CCGH7DG?HJ:J==B?.=AC:@@G6C/BFHICJ+IFIGH8G4H.GHHEDD7'@BCJ?IFFI4GFEC7GF8I<@EFGD?EEB4F5(CFECDFBEEFHDGHH:J;@?G=EF;G9BAHKJJAKGEKFFHEDKII@IBKKEFK?JKJKK>7K?J3KJG@KE:JJKJKFKGA&KC@JJFD@I;GAKCCJI=KIJII>;>KAIH>JIGEJFK:JGH63I5I;KJDJJIKKGJD?I>?EICKKJI;KJIKEJECEDEJGJHJ:IIIKJJJJGKJJGBKI5HEIEHEJJIKJKKEJGJKFKJHDKJCHJFJ8;KHIJA:HJ;JJJIKCKHG0BKKJJ?KKK@KHHKKKG%G;HIJJIKJFJH2JGIBKHJ;CKHFCIDKJGKKHAEIF3JHAEFKKHKII;GEHJIFJGAKKHJCJDI6KCKJKGFJ5GIK8AJ;HFJJK/JHEJHHKKJ'JCKEKKFKBK-KJIHHKJFEKKJ?KFK,GH;GF9JKDGJ5H8(KJCFIFC'JI=JK7KKKIGJBJI-KFGKGJHH;KJJ@G>HDIHIF9'G.EF?KIEEE1:ACKHJ(JFEIDIKJAHHJKGKJFHFJKIKKJIKGKIJ?JE;IHG0D2CHIIFADJEFHKKGIGKKDFIGJHII?KKDKIKHK3J>K>IHKKGJ,KKKKKKIJHJ:KKHKKIKEKG?J7JH@KJI>IKKBKJKJJHJJCCI5KKIK+AJKEI@K:JGDAEH?JKKGKJKJ6IDKC9IKKCIJ@KI>IFAGGJAIJIBDJIFHGKDHGIJIFGBEEFFE?FFJHKDJGKKKKJCH(JGKHKJADKJB?EHJJJKAGJJ&GJHIKIKIFJ*K=JHKJHKI>JJJHJCJICEGGKKGH?:G7KIKKFKHJKJKKJJHK@KJKKKIJDJFKJFJ;HGKKKDGKHHKJDIKIKKBKHJ>EFEB>GKIAIDG4KKKK7KKKA0KKHIJJKJKIHEGEJJH+J@FJJGKJIJBIAH6G;KG @rCer/7/24_1655_CCS ATGGGAGTTGGAGTCGTTGCTGCGCGGAGGGAATGAATGGGCGCTGGGAACACGCCCGCGAGTGGGGACGCGCCGGCCGTAGCGAGGGCCTTAGCGTGTGATGGCGGGGTCTGGTCGCTTCCCCGCAGCATGGAGGACGATGCACCAGTGATCTACGGGCTGGAGTTCCAGGCACGTGCTTTAACACTCAAACTGCAGAAAACAGATGCCATCGGTTTTTGGTTGGGACACAGTCTCTTAAATATGATAATCAGATCCACATCATAGATTTTGATGATGAAAACAACATTATAAATAAAATGTCCTCCTCCATCAAGCGGGTGAAATCTGGCACATTAGCGCTAGCCCGCAGACAGAGGCGTGCTGGCGACCTGCTACAACAGAACTTCAGACAGCAAAGTCCTGACATGTGCAGCCGTGTGGAGGATGCCGAAGGAATTGGAATCAGGCAGCCACGAGTCCCCCGATGATTCATCCAGCACGGCGCAGACCCTGGAGCTGCTCTGTCACCTTGACAACACAGCCCACAGCAACATGGCCTGTGTCGTGTGGGAGCCAATGGGAGATGGGAAGAAAATCATTTCATTGGCCGATACCATACCTGCTGTGGGATTTACAGGAAAGCTCAAGCCAGGCTGTGCTGGCCAGCTCAGCCTCCCTGGGAGGGAAGGGACAACTGAGTTCACCTCGGGCGTGGAGTCCGCATCACAACTGCACCCAGGTGGCCACAGCGAACGACACCACCCTCCGTGGCTGGGACACCCGGAGCATGAGCCAGATCTATTGCATAGAGAATGCCCACGGACAGCTGGTGCGGGATCTTGACTTCAATCCCAACAAGCAGTACTACTTGGCCAGCTGCGGAGACGACTGTAGGTGAAGTTCTGGGACACCCGAAACGTCACCGAACCCGTGAAGACCCTGGAGGAGCACTCCCACTGGGTGTGGAACGTCCGTTACAACCACTCTCACGACCAGCTGGTCCTCACTGGCAGCAGTGACAGCAGAGTCATCCTTTCCAACATGGTGTCCATCTCGTCGGAGCCCTTCGGCCACTTGGTAGACGACGATGACATCAGTGACCAGGAAGACCACCGTTCCGAGGAGAAGAGCAAGGAGCCCTGCAGGACAACGTCATCGCCACCTACGAGGAGCACGAGGACAGCGTCTACGCTGTGGGACTGGTCCTCGGCGACCCGTGGCTGTTTGCCTCCCTGAGCTATGACGGGAGGCTCGTGATCAACAGGGTGCCCAGGCCCTGAAGTACCACATCCTGCTGTGACTCCCGGCCTGAGTTATCCAGGTTCCACTGGGTGGTTATGCTCTTGGCAGGTTCCCAAACAGTCACAGCTCTTTGGCGGTGACTCATTTTCCAGGTGCTCCCTCTCTGGAGAGCGCTGTCCCCTTCCTCTAGCAGCAGCGTTTATGAATGGGGTGAATGGAGCTGTTGTCGACGGCACGCTGACGCCTGAACCCAGCCGCTGTCGGCAGAGACGGAGCCCCACATTGTTATGTGAATAACAACATTTTCTGTTTTAAGGGTGTTAGGAGTTCCACTTTAAAAAATGTTCCTGCAATAGTAACTCTTCTTTCTCTTCAGAGTAACAATGAAATAAATAAATCCACGCTGC + -&%+($'#(%&+,,('$,(*,'*-)(,%%(++(--(-+(---,))(*+(+'$%&$%*--,(#''***(+---+*(,(,-),,),+(,,''(+$((%%*,(,&'.*(-+*-/-.2/1/,//%,-.---*,0,/20&0,1,/(,,-,+.*,.'-1+-.'+),$*./.&-,.1,*',.)**1/20%*..'-0-01.-,/+,)+-*,/.),/12/$(),)111.02+.+10,,+'.1/-/0&,$+))+*)-+,+&*(*'%$)))'+,/.010)0/.%(+/-11+0./.%,-)(*&***+(&.00/11*0,*-,/,1(.,1*0-0-/.)0/*.,-0,//)+10--(')%($'(%./00,(-+(+,+*++''*(*+*))*('%)'((((%'"&'**(*,-+,,.0/&,0-,*,-+-,-/--,,*%$*')&&145,0542.-4(-//,1#'-*24.3(.,20-2021%/0/-,*034+-),0,2,,*&-15212-2'&.153-0//0*+/.)+.105536/-.(/./2+.*203455,%.%*-,4/3)552424124-3343*5)54161*1/2.3646/&00.1/4*5552)5)1*155.&25452#+/255651665.664322105625./*3206.15.'.43,(+/06,5-3623564162,-661*53,4/66'+%--30$&).2'-./5&31#$/..3441254/4301(/15440-554&01/604+02005+224444+2.-42,02511633-54213//556563.32141242/,/34%/4,214./04666.//51(,*14,32,/352+55564+5550164+55164262012.1415.04/2636/3422555)5/3*35/4+54$-152)2*01)2&03*+*%423126//41023-(+)324.)050/466/.2233+31*-)-06225.6212-,643265.6504.311-3/024,202/456,04652/2212004462421240,-3503,,.322-116/4320-62.--0004+2.2324665%,-/066466.6&/,/2636550020+4*/4625-/23261/.3026)33./1,///,0%-2506,3+1./-4).-/2)&/0/443102513+/56366414404-406415)-+./.3-520+10/33/)30/-0/$33)/1161/651+&%,/53635/64.2*654-40*2053465204304(41()53/4./50)32540/00-.&11/%2*5564*1500*21314.4325265-422*5.*01256352652566150512-10)2/-56340,//./,416551220)66,65101135005545)52,4424164+001$/1,)/215030.-6645,4&$1144/)/0//.%243(//6544115246.,53#33.(015*(15451-3566624,2/44.,*2006530(5/135/364456+530516565631/3)+/)*2/+.)/*1532/,464.642(.0-3*(/2(11+)230301*/2,)4(///-%*-.0/4)3$)-(*23&/3303/4*0-2(-/+3434346311*350350/-21514+2.%5212/4242.#1.,.311/2,208/83 @rCer/10/0_1630_CCS CGTCGCAGGAGGAGCGCGCGGGCACCGGTGCCGCTGACCGAGCGTGCGAGGACTCCGAATTGGAGGCACGATGAAGACGCTGCTGCTGTTGTGGGGCTACTGCTGACCTGGGAGAGTGGCAGGTCCTGGGGGACCAGACAGTCTCGGCCAATGAGCTCCAGGAAAGTCTGATCAGGAAGTAAGTACCTCAATAAGGAAATTCAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAAGAAAGAGGATGCCCTAAATGAGACCAGGGATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCTGGTTGGCCGCCAGCTCGAGGTTCCTGAACCAGAGCTCACCCTTCTATTCTGGATAACGGCGACCGCATAGACTCCCTGCGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGAGCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGTGGCTTCCCACACTTCGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCATCACTGTGACGGTCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGAGAAGTGAGATGTAAATGTGCTTTTGGACCTACGGGGCATCTGAGTCCAGCTCCCCGAGATGAGCTGCAGCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCAACTTCGCCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGTG + S5463&*1:-+85*56653%72'.0,(>975>=<>A=;>92*-<88:62;@/10)%#5>.?<>:*>.37<5)0'7<==66AA:9<>72(61=*;A@6>89@>@(===@5&:05@?==&>>:4=>?:2,??.:*7.'106=;1<:.?&A+>DF89=3>:>(B/8F.D.C@%8A*GHEAA=C6GBC>8576@C>@5&:==82?3CB?E8E2;5?@E>E@@BB,'>51,3,=7E:BH8B=>D6I::H-6:(0$C2=?967ED?7*GG=1JJF=1=6:C56D;**2E0F<@H,GGFH6IF;,'-5C+C'+DBAE3B7:+HI8=E?2DDHH53?'?5E<@EHGG>BF>IEE@F>:<6D5B9G407&=02:4A+@#CF/D>?BFA.1FF;+8*@++$3F@8B%$H/E6ECH54D4FB05B4@/7.4;8+A:@<@IGD441>9CG2=JB7JB?B?G79/I?IIE>B;H(0A;@H7@CG>@:9FFA;.H5G<;J8D31@7EG7IIB5G6)H,5&?A'%;0)&(=9.-?)5.<';?E9FIDGFFG6FCD,FCF?'E(EE56&DC+2(A-0CB$<7$A@,C9>'EFHF6BIF>EE>>:B=5E/C>:=?HDAF3E4G?8-E+%'75IDIB:GC58=BC8B8=E55I=D84AI?JFF9??<&=0JA2HEGEA*5ACD=I4JEBH,HG8/EHB:C;?F>7HGBHFIG:FJGF??E/CG>7:;1FI>@G>@GFICIF@-6;,D9FCFGE=51$G>@F5HEGG5?FIHD;CAIH=G*?HF9I%@ID5H>>BI2:?BFAH<5B9>3II9=?F7E1J?;=5=*B2)F25DF6HAD/D1F0C4G8I1..7?>5G,1B:+FB?688=:5D@9@6?DHC;5D>IAB=@B>3G)F;2J8IJ43DC6FDG:=J)2:>%B==J=+F;?-IIHEIG:HH;,E*J8BHJHI+EDEB3A-C3(G/B5CE>@9H@7DC,JF/5%;E(IFF4G;AE5FI4IEFE@ADBE@?9:B8:4&:&A@BE;CF@0F)CCF2:7G6&A;3/%GBG=HH)@BAEDB=/@D4D7IG1>)=>>D*07B6?A;58<<*F1:@8B<@9CIA9HH0DHFD;B0:EBID7&@:I>;HF+FGIH:GE<%@>>?@7?EF:8AF @rCer/11/487_52_CCS TGATGCCACACACAGTCAAAGCTGAACTAATACTTCACAATTGCATGCCAAATACATTTGATCAACAGGAACAAGTACCCTAGAGAGATATACCGCGCAAATTCTATTCATTAGAGATCCATCCCAAAATCTTACGACCTCCGATGTATGGATCAGGATCGATCCTAATGGTGCAGCATGCTTATCAGGCTGGGTGTCGTTTGTCTCACACGATTTAAAAAGTACTACGGTGATCTGAGTTTCAGCGCGTGAGCACATCCAGGCGGTTTTCTTATTCTAGTTGACTTTCTCCCTGTACGTAAAGGGACAAGAGTAAATTAAGCGCTTCCCACTTCACAAAGCGCCTTCCTATCATTAATAATGATCCTAGTCTTAATTTAGCATTAAATACCACACATTCCACCCGATAACAGGGTTTAAAAAAAAAAAAAACAT + #*&""*,+)%.)#,..,.&--."..+-&'+*-,.$&/.-#/$/#',#$+,#--,#..),/-.-+,#".(%'&&,.(.,+,--."+#*...+..,../--*-.%-,%,*-#"**-'*"'')*!!##%"$%")*$++-',++"-,....",.&///./*/".*'$-,--..-()/.*.,,##)"#'+($""""!+'+#**,-(,..#,--"-./+.)(,&.+,..&/"..%)-....$-"+$(+/*/+"*."%,&)'"(-',+%$!)$##&#+#&+")(#&#%''--+),+.+**(("&..#.#'.)#..--.%,""!--%-%.$-%#*#*$-..&-&,,(+-).*.&&--&%$//").-#+&(+.#--'&&&-(%%-+(+-.%&$#)+.*..+..*//,'.,-.+,//#,+..+*(,&).''('&)$**(*'++#$ @rCer/13/2403_78_CCS GACAGTTACCATGGCCGAAGACGCAGACACATGCGCCAATAGAGCTGGAGGAGATGCAGCGAAGTAGGGGTTCTGACCAGTTGGCTATTGAGTCGCCTGGAAGAGCACCCGTCGGTATGCATGCAAACTGGTTGAAGAGGACGGTAAAGATTGCTGGTATCAGAGATCTTTGGTTATGTTGGTATGAACAAGCGAGAACAAGACTGGAACGCATTGAGGAAGGGATGGACCAAATTCAATCAAGTACGATGAGAAAGAAGCATGAAAAGAATTTGACGGACCTAGGAAAATTCTGCGGCTTATTTGGTGTGTCCCTGTAACAAGCTTAAATTCAAGTTGGATGCTTACAAAAAAGCCTGGGGCAATAATCGGATGGGCAGTGCGGTGGCCAGCCAGCTCTGCTCGATGTAGTGACGAACGGGAGCAGATTGGCCATCTAGTGCGCGCGCTTCATCCGCAGGGGTAACAACATGATTGTCGAGAAAATGAAATGGATGAAAACCTGGAGCCACGGTGAAGCGGCGTCAGTCGGGAACCTCCTTGTCACATGGCCCTGAGATATGAGGCAATGAGATCGATACACAGAATCAGCGCAGATCGACAGGATCATGGAGAAGAGCATGATTCCAACCAAACCAGAATTTGATGAGGCACAACCAACGTGCAACACAAGATGCTAGGAATGGTTAAATGTGCCCACGCCGTGTTCTCCTCTGGCGAATGCTATCGGGCAAGATAGCTCCTTCATGCTTTTCTCATGGTATTATCTAGTAGGTCTGCCACACATAACACACATCAGTCCACCCCCATTGTGAATTGTCTTGTCCTTGTGTCATCTGTACAGCTTCCAACAAATACTTTTGTCTTTTGTCTCTCTGGGTCTCTTCTTTCCAAAAGGTTGTATATAGTGGTCTCATTGGGTATCTGTTGCTCTAACTCCTTGAGTCGTTGAGTTTCATTTTTCCTTTTCTCTCCTCGGTGGCATTTTGTCTGAATAACAACAAATTTAGGCAATGCTCAATGTTGCTTTGTTGATTCGTTCAATTCCACCCGCTTCCCTGTTCCTCTGTAAGTAAAACTGTGGATCATTCCACCAGAGCTAACGTGCGCAACACCAAGTCCTATTGATCCAAATGTCAAGGCTGAACTTGCCAATCTCTAGCAAAAAAATAGTTCGACCGTGCTTCGGTTCCTCTGGCTGTTATCTGTCCTTTAGTCGCATCCATCCCCAAGATTAGAACAAGATTGCTGGAATTACAATAAACAGCGTCGATATGCAGGAGGTAACCGAACGTCGCATGTGATTTATGACCAGTACAACATTCTACCTGGGCAATGGATGGAACCTAACACCCTGCAGACCATTGGTTACGATTCGCCCGCCTACTTAAACAAACAAGCGGTTTCCATGACGGGCATAGGCATAGCTGATGGACTAACAAGCTGCACGAACACACATCTACAAAATCAACAGCCCACAAAGAACCCAATACAACCCTCAGAACAGAAGTCAGAGCAGGGAAGGCCACACTGACCTCCAAGTATGAGAGACGTGTCAACGAAATTAAGTGCAAATCCAGGACAAGAATCGACCTCACAACTAAACCGAGCATGCAGGTGTGATCTACTTTATCAATCACTCTGCCAAAAATTTATGATTTAGGCCGACTTACCTTAAAATCCTATAATCATCCTTTTTTTTTTAAAAAATAAGAATTGGTTTATAAAAATATGCGAATTATGACCAACAGAACTCACCATTTAACTCCAACTTTTCCAGCACACAATATCCCATGTCTTGCTCGAACTTATTCCGTTAAGGATGGATGTAAGGAAATATATCGTTTGTGACTAATCTTCAGCAGTGGGCCCTACAGAATTCTCCTGGCAGAACCCAGTCGAATCAGTGTGCTGGTGCAACACCCGTGATCAGACCTCGGTAAAATAGATATCTATAAAGGCGGCATGAACTCGTTCTACTAAACCAACAACATTGTGCCCATCTGCTGTGTCCCTTGTTATACAGCCACAATTCTTGTGTGGCTCTATCGTTAGCATGGCCTACACCAAAGTTGCTAGAGCATGGTGTTAGTAGCTGATAAAAAACCCCTTATACTGACCACAATAATATAAAATGACAATGTCACAAAAAATATAATCCCAACTGCGTAGGATCCAAATAGTCTCACTGCTTATGAAGCAGGTGGTAATGATTTAAATATCCCCCTGTCCATTCTGTCAGTTTGTGTATAGTAGACCATTGAAATTTTGTCGCTGTTAATTATTATTATAAAAGAATTGTAAAAAAAAAAAAATAGAAACTAC + '##*-*&,((--&),,,.-..,/./'...".+(..+)--."..&-).)-%-../.&-#----&,$*)%&##&,(,,,#+-$$+',,&#*..#...$.-'--,"+/.).,,$...,.///.$//.))-,..&-#'*%,-&+../+-,+../.$/...*./////",.#..),/,/*-..-#.'--&..+-(+%&'.-.,.--")../+.(//../)./-(,-.+),//)/.-+,.#+,.).",+,#''#////!-,..-'('.#*.'(+&-,.)*..&.(,'*'#(*,%)&+),./-.).(%#-&)-+.....-,,.)/-./--///+/,/+&/+./-$.'.//./*/+.*+*+.',.'.#,(---.&-.'-(&&-$))$,"')*'--)*(',*,-+-(+-.---.#.)-),'%,,..+'.+&.,&,&-)(.)+-.&-"..(."+..#-./*.//../-)'"''---.*-#.*/.%*+--.%-.((.///+.+),),+***.//./+/.+.'#/*.$#.,..(.$.//".).+')%--.+.(#+*//.&//&,+,&..-//./-$.*.../..,%.///#.../,//-//"/-"--.//.///+/*.//-/-&-./-.%-.#*..()*),,#-'+-.-.+.-+%#,.&.,.)-(*-&--,.,..-.-./.()-//.(.--.).-./-(*/,./..-*-*/.#,(/..'*..,.(...*...-&/..-/-.,'.%.//...-++-(%/...--'(&-,)-'-$-'-)-..-..)--*--+*&+,),,$$-+(-(------'-++*+&#)*.-(-../-.$.,)-%.)(,-%./.-.*//./."././+*.,+,--+../,.%,,--.&,&.+,....*..,))....*..),-,,(*&(*-$+&+'+..../*--,+%'"!+'++'!'%,#&,.-..-.+--.)..-..",)-/.,),//*(*+&-..),,/').-.&./+&)'(.-&'$$*%(-.-$-).--..(&,*,,.)$.-./..-../+*$.-,#%%+"..&+-#&).--+&-(,(#$('$$&#&$+)$&%$%+"+'('..*+-//.--#'"-.,(-,-,$&,-)...+/$.'("+%%('%$(*-+))##%)&"%##)##,,,.*(-)-,$'#$'#-%$*,...-+*%&-%($'+,,&+,$#,)++,##&($,-'-',-,&--&.,-'((----,*)+%#*#&%+&-*)(#.+&$&(&..-$((&'',+$+$%()))&%#"#%+'+,&(+,++#("'$+$(&+*#""%%#&&)((&-+#-+(-$-,%'-((((*..*-,,*$(+('&$$'-+-'(-$$(+'&,%&,",".%--).)-)))(&",..(&(-&##$#''(,%#&&"'$"#(*,,,*)-&'+-*-----.%).),--..'(*""""#()##*&'&#*)+*'%#($$#(%)'%$"##'*#*(&*++++)""$&)%$+%,,+...*()..,),*+*($(,*(#-('($&#&%++*-,(((###&#)"%)##"*)#()$$"&-....+--+'----%"''*$'+#%'$')*,--(.-%.(-&%*'$%#)(+#$*()&!)$&$"&''##$#'(*"*%)+&+&#&&&+)##%&*&*)((#&#"$))(#,,-(+(,$##)+)())*$#--,&.,#),-#$&&)*#,*'-,%#(%,-,%#../-//./...%'%(%)(&+.)(()&",,-.,-#+$)$)+%-%&))"&%'#')&-%'%*-+('%,+&##+,((,+++%$,)(+#)''&*%$#'$#*()$'%%#)'+&###''))*##"'&&+(%,&-(&&$--'-$'$-*,&%"'%(#$#)%(*((#""%###$"))*,#(,*+%$%$#&$%"*$##'$+*$+''+#%'$%&(&&''##'&&+)&#)+&,-,*-$*&,*$(,+#'*++($%(**&$##&%##'#*%+,%&("###+*&))#'($)*"')$++-))*'&*"#"##)(*+'*,++',(&-,+$$'$&#)$&)$*&$($#'##$)$$'&&,'+*'$$#*+)+&-'$#)&$#+)+%'%&"%#%%###"%'%###)++))$)#$'***'*)*+-,+(*%'#)%$&$*)**#'%$$%&#$$###)#))$#'(%()----,,,&+#$*---&(*+*#++%%''&(%'"$#)%'$&**-+%&*#)"$)&%"#%#)*"$(((()*%&#&$*$#((%)&#$'#++)&"'#"()&'*('$#$#&$&&#&$#%++-,,)*-'(+'*$$"&&(#**$&,+&+%$%&$$%%$#'(%)+%%%#(**&$*&%#'###"($"##&"##$####$%%$'(*))##((&( @rCer/16/25_1478_CCS ATGGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACACTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGTCCCTATTGCAGGATCAATAGTTCTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTATCGCGACCTCTTCTCCTGATCCATATCACCATTATATCAACAGGACTTAACATACTATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACACGAGGAGCACTCACACTCACATAATCAACATAAACCCCCTTCACACGAGAAAACATTAATATTCATACACTCGCTCCATTATCCTTCTATCTCTCAACCCAACATCATCCTGGGATTTACTTCC + 25#959&8''2=8:A:?B@.@AA+;A;DF;>FDC'CDB,D9@@9B;BBB7F;DFBI>G;@D6=>:C??I:(HECFA=I9GC(C;IIFG4D8AFA/:(:=CH>J?>I;HIC8FE;C8JJKBK<5F7GBC?:HEDDIHE;FBEF(E4I<:FDJH7*@?IGBIII>80?>+AB8G7E+F=/G9GCBFK9JAJJIKIJ3JFJHG>G+J;GCA=HABB>I=BI@=8HIFF;-C;+BC4)A>E@AE9:?61H/3?GJ6JFBI>H8=@+:8<1=2DD>DF9IF34F4D?D80BBA;??CIDHB?;C312C(68+/(?C9F;1DCBC*FEE,GFCHDAD9HGB>?A;;IAHHIC<*CD?:AACC=-9269;A;GD936<7.GHHJ>=1A>3@@;07'A:E?13<*CDBDAGB:G(@A8IDA0==?@F?FF=G@C,CH?F/CDGDEED;DEIFD@CD4;11B=8FHCB9FBBE8HE@D@,F7B?4B?@D<;9+E;:,$B9@@H5G+B0F@E*E/G?EH1HB4GEH2=42GB@ECH:EEECEGEIH=B:<@&3A5FGG???4BDC;07@G?F9>G98B:@<2+@@=BC54%DFE?C>HG2$A=BHA=8C9@@H?59?<7=4FI4GCBGFGGGH>9+A)B@4FG99@/8B9A.@B1IG@;EF=J5BE)GHFE@D7HHG(GF;:F@IABD&BDD-EJDFCEIJ@79I9B<5@/:&@DDBA;G==DDGEG/?<@EJ=9<6A=EFGD6DGCH@7CCEE==8+.26.5-256.3.'0-.01,69010,4,.*/-5-5884.<40335780662790./*0712517915+608/&0+3,95-161''828;8725/+..5/9/0985559=76597)48;5#2792<76=18(/58/6.89=2;4(%,(%&1,(3+3&28%7037;1,6?)8462436#28=93;'67*3.-'6.:;10::;0112:6+2951.1742$0;:2;7562,)033)+%3893<5840*8,27(51#269:39136:85,3':7/)&&'&/'&'60+4815'0897>87%27.0.6-202.6489>:(+':90<0/<01%-3-8?=513833/106 @rCer/18/26_2169_CCS ATTGGGAGACCACCAAGAAGACGTGCAGCCACTCTCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCATTGGGCGCTTCTTTGGCGGTGACCAGGGGTGTGCCCAAGCGGGGCTCTGCAAGGACTCACACACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCTCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCCAGGATTTGCTACGGAGGCAGAGCGTCCGACTATAATCGGCTCACAAGGGATTCAAGGAGTCGATGGCCCAGGGCACGCTTTCCGAATTTTAAGCTGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTGTTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGTCACATTTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACTACCCTCCACCCTTGACTTTCTTTCGCCGTGACGGTGACACCCTGCGCTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGAACAGTCAAGGAGTGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAAGCCCACAGCCGGAGAGTCCAGGAAGAACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCCAGCCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCCACCTTTGATTTTAGCGGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCATCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATAGTGGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAAGTGTACACTTGTTCCTGAAATTGAAATAAAACAAAACTTTTAAT + '$%#(('$'%&&"''($()(%&$$'$&($&,'$)%')*,'%')(+(*(((,+--.---%,-*'(-+-,,%+,&&-+%*-.,-(*.,())$'&(''&(--*++*%,)()&(,-)*',,.,()+))')'%,('*$'%())-*&,,(,*+(***--)--+'****%,)-*(%&'$$)()'(((,(&++(*,)*,&'$$%#'%$(+++,()$,*&++-(------+#*%''*++&%*+'#%&*-*-,$,+',&*$'##%()),(),(&'--*$(*&&)----),-+)-,,&-)&&'),,(),%+++&*),*-&(*(+.,),)-)++'*(+.--+,-,(*,()+*------+*,*.-*,#)*-+%)('*)',,(%#&&+,-,&$$'''(----(+,-+%##"""##'+&%*)&(*-,),(--$&#%,)(+-*$#%',%.-),()%(),'(',-*,'-)$&&,(+*,))*)+(-*(,,-)*#'$'''()*$&),,,'*+&(*,(+**+,!#$&+,,&,,-'$*)'-+-(((+$+---,%($"#*%)+('+-+,)-,+)+(&*(,%$&$'%(-))-*""$&'),.%&&+()-,$-&()*--.+-.,-*)*)$---)-,--.-)+&,)-+'+('#))'$++)%(.-(*$%(%+',+--+-++,)$+&'&$*-+,.)*&-,(*%+('-*--,*---'((&$$()'+,%)(&%%$#'*'(&,,')*,.-),(*)*)*.,,(+*,-,.-,-$'&,+-()''*%*('*&#(***(,+-)%*'')+&(+-)-)-,,,*,-,.+)*),,$++(++.)(*(('('-,'%$$+++++((-,*+,-&),.,--)*+%*+--+-+&$,-+,&*$)&,,,,,(+-&,---+(%%"#$))(-+)-+,,#*-*.-(#****+.--,,"$*---,'',,$&#,+$,,*(++..---,+-*,-(*''))'++,')-*)*,-,$&(')*&--+-),,,-)-,%,--,)-,(*&')&*--+()%(%()--.*-((#+)(&&')**)(&&'*,(,*)*((''##)*+%"%+--,'%(',,,&*+,+(-+%*(++-)+.,,(),)%+,(-'*(&'#%$$)--**-,+&+..+)(&)+),.+'+(+--+'#)*&,)&,(+--,-&((&*(+)'&''-(-(*)#'$#((*,'*,-*)+'*''+*(+,)#+''%*-)++$+.,--,.--+&**$*%')-&*&,---+.-)--(*-+*(,*--+*-*,('(--,))(')+),-++)'+))&$(((**'+-)-&&,)*((,-,(--,$+&$#'**+-*-(#'+,,-.,&*-)*+--+++(*,-,)*),()&(),&&&'-,'(*+&''(),-,,)+(,(+++,%)(+()+,,),),,,'(+-).)'*()-,-$)*&)'+-*-,*%+-(+*,,(+))(.*+)&*+.,*&%,&#'&#,&+-,,-),)*)))++-,+.-)+,.(,--*),(*,,(),'-((*$),)#('*--)-,-,)+%*+()**('##$%-)--,,,%%$)#*+)+&).-(&*'),),))%+*++,(,,.,),)**),,..+)*-,(**),,,,'*'+"%+(+--(-(&('#&%#$&(,&,,(()))&'',(,-----)(,*&'&(-*&,,(*(-,'"$)(,+'*&(('''*+-*)+--**)(*-.,)(*'+'-*$).*-*-,+$$$*(*(,,+.-,-)--).-+,-,'+,(,),&(&()(,+((()((((++'''%)-$(),,*((+*)--)(),,*,).-,-+$*%'%'($$'))&('+-+)(*'*&)$*))+,(&+,-(,&)'-+.-)*+#+*&&&'+-,(-,))&-*$"")++%&++),),(',,)*-*)&%&&$,)(--+$+,&,$(+(&''''(+++,(+'*)%)---*,,()+.)'--.-,*-,')(()(*,)**)-,,)+%''+,+(*-+-&--),(,(*-+,()))+),(('--,,*(+*.$%'-+&-,+&&,(**(,--)($&)(-,(-*#)*(&)*(,---,--*$,(&+-,(,,))-,-')&')),(-((*,+*)((')&%$$(#%##%%((%(''))%%%)))(&()&))(%(&%(()'&(#&'()%(((()'))&(#$%(&)$$#"$)&%((&)('%(%%%$$$)'$%&"$)% @rCer/20/1755_81_CCS TTATCCTCGCTCGGGACGCCGGCCGTCCTAAGCGGGGACGCCTGGGGGCGGCACTGGTGGCGTCTGTGTGGAGTGGGTGCCATTCGTAGCCTCGTCTGCCTCGAGTGGTCTTGGCGCGCCGTACCGCTCTCGGTGACCGGGTGAGGGAACCTCTGTGCGGAGGGGAACGCTCGCTGGCCCCCAAGCGCCCGCTCCTGGGGTTGTCGCCAGGGCGGCCTCCCGCCAGAGGATACCACTCGTTGTTGAGATGATGGAAATTGAGTCCTCGTATTTTCTCTCCGGGGCCCCCACCTCCCCTGCTCGTATGGTAGTGAGGAGAGAGTGTTGAGAGATTCACTGCCAGTAGCGCCTTTACAAGGTGAGAGTCTCGCGTGTCCTTCCCCAGCCACTGAATAACCAAAGACACATGGATTCCTATCAGAAGTGGCTTTGCCAAACCCAAATACTCCCCAACCGAGATCCATTTTGGAAAGCCCTTACCTCCAGTCCCCATCTTGAAGTTGGTCTGGCTCCTGGCTCTACGTTAGGGACTCGGCTTCTGTCTGCTTACCACTCCAGCGTGTGCTTGCTCGTGGCAGGACAACTGGATAATGCCACAGCTTAGCAACCCCTCTCCAATGCTCACCTTTGGCTCCTCTTGCGCCCTATCTCGCCCTTTGAAGGCCGGAGTGTGGCAGCAGCGAGGCAGCATGGCGAGCCAGTTGCGAGCCTGCGCAGAATCTTGTAGAGCATGGAGACTCTCTGACACTGTGGGATACCGGTGTGCATTGGGTATTCTTCCTAGCGCGCTGGTACTGTTCGTCAGAGGGGCCAGAGGTAGGGGAATGAGTTTTCTGATTGGTCAGGAGGTTCCGCGAGAGATTGGACAACGGTAGCACAGGATTATCCCTCCTGTAGTGAGTCCATTCTGCTTTGCCACCTGCGAAGTGGTGATTCTCTAGTTGGCACAGAAGCAGTCACACCATCTGACATGCTGCATGGCTGTCCCGGATTGCAGGGCGTTCACGACGTCTTGAATGGCTCGCTTGACTCTGGAGGTCTTGCGATGTACCAGAGTGCTCAGAATTATTTCCGAAAGAGTTGTTTGCCTTGGCGGATCTCACTGCGTGCGGAGCTCTCCGTCGCTCGCTATGCTCAGCGTCACCATAGGATCCTCAAATTCGGGATCATGGTCGCCACCCGAGTGTCGAGCGTGACACGCACACAAGGGACACCATGGGGCCACTAATGGCGCCTGCTTCTACGCTACGCCCTGGTGCGCACAGCGCGAAGTGGCAGTCTCCTTTGGTACGCGCCCAGGTATCCCAAGACGGCGCCGGCTCCAAGCTCGTCTCACACCGCAGCATCCCGGCGACGCGCGGCAGCGCCACAAATGAGGACACGCGGTCTCTTCTTAGGCCCTATTACAAGGGTATTCCTGTGACCTATGAGCCCGACAAGTTCTTCTGCTGGGCTCCGCTAACTGTATCTGCTAATGTGAACAGCTCCAGCAGCGCGCTGGAGCCCACCGCACACGCCCCCATCGTGCCTGGGCGCCTGCGGTTTTCTCACTCTCGCCCTGCAACTTCTGCTAACTCCTCGCCCGCGTTATAGAATACGTGTTGGAGAGAGGTGGAGAAACCCTCCCTGCTCTCACGCCCTCCTCACCAACAACAAACGTCTTTTTTCCTCTTT + -),.))&)+'(%$*'-.-+.-**--&*,$-,-,.)%'.'/*-.-)&((.#*,..+.),%&'%,#-,+,-.*)-'-)$,,$&-%+-.-+(**%,-,*,*(,+'+'&',%((+&'**+&,%),),&(+')**).+.--,--)("&,,)'+*'+*+,,%-,-)-+''%**-.--(-,-.*)*'%%-%.--'*+")'#(+)$(*'+,),,&)),($'-(&*+#)*+%$$+*)%*+'.,,..,+.(,+%,##%+%+(-",'-,#-,+,++,----,$(****,*,-(&#%(&&$'&)&$*(,----".+(--)$&(*+&,(-+-+-*-+-'..,-*%,'(---*'#,*'&*(+'*,%*..(+&+..,-..-....)//..-+'*$+)(//'--.++.,#.-&+%&-."(-..#.$..%,-#--///++//.*&'()%*%(*-,(&.,,....+,)%)+.-,/#-/)-/.%%&.)-*).&,-.*//..,-/.(*'(*,-&"*.'+.'"/,*/./,---.&)',-...--+$-*&#'')*-)+,#+'-,,#-$,'&,+&--&),-'*++$*&)'&*&*+),)'-.(,-*,.--+-++'-.),-)')&(#$%)'(%#&)*##)(&,,,(*('+(,&#-)(&()*+#)-+-'&(,,.)*%.&*++(*,'$-'&%+(&,----*.,.-'.+-,,)+#.,)--)+)%-*-,++#-++++',,-+-.*.-++,.$-,&,.,'"&.*"*(...&,..-.&.--'*%+*+,.-.)#++,)+,'-($,,.),.)-(%(-'/,/$//,*--./,*-/#.-+-&+)''"'.%,),,-%#$%+-*,,%&$&...-/).(#'(%*($&$*&-&*.%,#,-.(.(-%,--,-.-.),-+*),-$--''),(.----++-&'#(+)+&,$-,&,*.)+*..-)+,-,+*,*,+++&($(*+-&,-*+-+--,,..//.,.+.-+./(.--.-%+,"--.#.*$$..+($.),-#-+.&+*..,*//./....")&-."//,---/,/#.+.".,/+..+'/"+/#/+.#+,&,(/-+-,&.)..&-.)&"&#$#-%)).",-(%.'*-')(#,%-.&...----..,.-'(-(-,*)'((*-+(-')'+,&+--*-""(*-,%.-,&)-,)--,&'*+*+.(,-*'-*+-+(),*+*,-(*+-.)**#*,,+)+*',--,-)*+,+,&$#$+*..,...%+%&(&(+,&--)+)#,-.,,&,,+%,+,+,,"&('-*-,+-+-&+**)&*,+*+,(.---+)%(%(&,$,%+,*-)+#)%(#)-*+*,,,)..)%,(+.&(.,,++.-#,-,'**,+)(%&%+/-//-,&-&).+-.-/,/*,(/(.+*---+-&..-('-..-,,#'#..-)&,$',((-*."-#-,+%-*',."+,,-+',-$+,..-.((**,#(+#-,(-,)*-,,,,'(--*$,+*)"#,++..*-.('$%+,),&,,,-,,)(-,'(,)+)****#(+%(%,+'-,),*+.'+'#&(*%*&+$-,,+'()#$,))-'*')),)'*&($$&-'*+,--,+--$$+'$+(&()'%++-$&$+'+&$#+'(((..-,-..(.&,.-.,.*-.#,+/'--,,.,&-.+.-,--../),&&+,-"$.--..,--,+...-..(*&+,',...*+ @rCer/23/1597_61_CCS AACATGGGATGAGCAGTTCTCTAAAAACATAAAGCTTGGAATACATGAAGACTCACAAAATCGGAAGAGCTTCAGAGCTGTTAAGGTACTACACATCTGCCTGGCGATGAGATGGTTCTCTCAAGGATTACTGCACCAGAATGAAGGAAACCAGAAACATATCTATTATATCACAGGTGAGACCAAGGACCAGGTAGCTAACTCAGCCTTTGTGGAACGTCTTCGGAAACATGGCTTAGAAGTGATCTATATGATCGAGCCCATTGATGAGTACTGTGTCCAACAGCTAAAAGAATTTGAGGGGAAGACATTAGTGTCAGTCACCAAAGAGGGCTTGGAACTTCCAGAGGATGAAGAAGAGAAAAGAAACAGGAAGAGAAAAAACAAAGTTTGAGAACCTCTGCAAAATCATGAAAGACATACTGGAGAAAAAAGTTGAAAAGGTGGTTGTGTCAAACCGATTGGTGACGTCTCCATGCTGTATTGTCACAAGCACATATGGCTGGACAGCAAACATGGAGAATCATGAAAGCTCAAGCCCTAAGAGACAACTCAACAATGGGTTACATGGCAGCAAAGAAACACCTGGAGATAAACCCTGACCATTCCATTATTGAGACCTTAAGGCAAAAGGCAGAGGCTGATAAGAACGACAAGTCTGTGAAGGATCTGGTCATCTTGCTTTACGAAACTGCACTCCTGTCTTCTGGCTTCAGTCTGGAAGATCCCCAGACACATGCCAACAGGATCTACAGGATGATCAAACTTGGTCTGGGTATCGATGAAGATGATCCTACTGCTGATGATACCAGTGCAGCTGTAACTGAAGAAATGCCGCCCCTCGAAGGAGATGACGACACATCACGCATGGAAGAAGTAGACTAACCTCCGGCTGAGGATGACTTACCTGTTCAATACTCTACAATTCTTCTGATAATATATTTCCAGGATGTTTTTCTTTATTTTGTTAATATTAAAAGTCTGTATGGCATGACAACAACTACTTTAAGGGAAGATAAGATTTCTGTCTATTCTAAGTGATGCTGTGGTACCTTAGGCACTAAAGCAGAGCTAGTAATGCTTTTTTAGTTTCACATTGGTTTATTTTAACAGACTGGGGTAACGTGTGTTGTAAGATGTATGTAACATGATGTTAACTTGTGGTCTACAGTGTTTAGCTATCAAGCCGGATTTCTAAGTAGACCAAATCTTGTTATTGAAGTGTTCTCGAGCTATATATACCTGGATGTTTAGAAAGTATTGTTACATCTTGTAGGATCTACTTTTTGAACTTTTCATCCCCTGTAGTTGCCAATTTTGCATGTACTAGTCCTCTAGAAATAGGTTAAACTGAAGCAACTTGATAGAAGGAACTCTCCACAGGGCTTGTTTTCCAAAGAAAAGTATTGTTTGGAGGAGCAAAGTTATAAGCCTACCTAAGCATATCATAAAGCTGTTCAAAAATAACTCAAGTCTTGTGGATGGAAATGTAGTGCTGGAGTCACATTCTGCTTAAAGTTGTAACAAATACAGATG + C688,9;(990765:4B/=2;4:GD?-B7=;E2C:6&F9E99DE?7.K5=ED>EHJIFJ08IH,>5B$IGD$JGBIECFKK@I;D2CGH9EH?>AAF6B**(:=K:KKK&FIKKCKIIKDKKKKK1KDJKKKKFKGJJKDFKKIJHKKKKK1KK'KKKK.KCJKCK>IBJKKKKCKIKKK@K?KKKKKKKKKKJIJJKKD+K3KKIKKK1ICA@KKJ>K:ABK:KKKIKKKDKHK@KKB.D.KKKJKK:EAKKKIHKK;AKAKIDKKKJ=?KK.JKDKKK1KEKGDJK=KBIKKK/JKK$3>K(FKGKJJJKK1KK/KKJK9IKJKKKKKKKGKE?>KDK;KKKKJKKK8KKKJCKK:FGKKKK6KKIKIKEK/DKKJKJKKKK?GKIDK5KIKGEKCKKKJ:GIHKKCK@KKIFJK2DKEGK?>?KHIKIJ+=6K+K/K;EA?KJK$B2D?K@KI:K*K9F8K9IJGGFIBKAKIAFIFKK+KKJKHH.BKK3JK>KKJJKKFG;DCJKKBK;HGKKEKKJKIIJK8FGKKKEHKKKKKIJKKKEIKK(IEK@KKKK':JJK@JHJGHKKKJKKGJKKKJ@?:FKJK>K.FK/HKJEIAJKIK9DKFK;KKKJK'EKKJIKJJJGKKKJKK?EGJJJGKKKKKGJKKKGKKK3KKKHJ@JKJDGJKKKKK&IKKK=JKKJJ?K0KJ=>JKK,KK;KK3K@JKK=KK>EKKEKK@KKK2EKIKKHECFGJHKK=H>:FKKF=K$J(F>JHEKDHIJFK:KK3KJCKIKEKKK/FJJKKKKB @rCer/24/25_1646_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCCACTATTATGGCGATGCTTCCTACACTATATCTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCTTACAAAAAACCCTACCTTCAATCCCAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCCTACTCGTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCAACACCCTGCTTAGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGATCC + 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@rCer/26/0_1635_CCS GCGGCGATCCGAGCTGGGACTGGCTGCAGGCGGCGGGGTGCAGAGGACGCGGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGGTCTGCTGAGAACAGAGCCGGTCCCTGAGAAGGGAAGATGTGCTGCCACCATCAGTGCCACAGAGACCCTCTCAGAAGAGGAGCGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAAGAAGAAATCCAGACTCTGTCTCAAGTGTTAGTAGCAAAGAGAAGCATCTAGCAGAGATCAAGCGGAAACTGGAATCAATTCTCTACAGGAACTAAAACAGAACATTGCCAAGGGTGGCAAGACGTGACAGCAACATCTGCTTACAAGAAGACATCTGAAACCTTGTCCCAGGCTGGACAGAAGGCCTCAGCTGCTTTTCGTCTGTTGGCTCAGTCATCACCAAAAAGCTGAAGACGTAAAAAACTCCCCAACTTTTAAATCATTTGAAGAAAGGTCGAAAACTTAAAGTCTAAAGTAGGGGAACCAAGCCTGCGGTGGTGATTTTGGAGAAGTCTTGAATTCGGCTGCAAATGCTAGTGCCACCACCACGGAGCCTCTTCCAGAACAGACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCACATGCATTGCCATGAATTTCTACCAGATGTGCTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAATGAAAATATCTTCAACTCTATTCCTGGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACTGTTATAAAACACCTATAGTACCTGGGACATTCACTAGAATGATCTAAGAAGCTACAGATTGTCATAGTTGTTTTCCTACTTTACAAAATTGCTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTTATTTCCTTTTTTCCCCCTCTCTGAATCTCTGTATATTTGATTCTTAACTAAAATTGTTCTCTTAAATAATCTGAATCCTGGTAATTAAAAGTTGGGTATATTTTCTTTACCTCCAAGGGAAGAACTACCAGCTACAAAAAATATTTTGGAATAAGCACTGTTTTGGTATAAGGTACATATTTGGTTGAAGACACCAGACTGAAGTAAACAGCTGTGCATCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCCAGTGACTTGAGTGGAACTCCTACATCCTTATTTATCACCATTATGACAGTAAACATTTCAGTGTATTGTTTATTATACCACTTATATCAACTTATTTTCACCAGGTTAAAATTTTAATTCTACAAAATAGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAACTAGCCGGGCGATGTGGCGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGAAGCTTGCAGTGAGCTGAGATCCGGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCGTCT 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rCer/29/0_3927_CCS AGATAAAGTTACTCAGCCACACAATGGAAATAGACACAATAATTAGTACCTTTTAACCTTCCATAGCAATCAGTCACAGTCTATATCAGGGTAGATGCGAACTGTACCACTAGAGTGCACAGAACGTAATAGGAACTACAGATATAATCAATTAGAGAATGGAATACACAAATGCGAGATCCTCTTCTACACTCTATAATCGATTTATACACTACGAGAATGCTATTAAAGTCACTCAGAGAGATGAGATCATTCACTGATTGAGAGAGTACATATAAGCAATAAGAGCCGCGCCGTCGAGACATAGTCAATACATCTCTAGAAGACCAAAATATAACCCACAATTTGACTAGGTTGAGCTCAAGCAGCTATTAGAACACTTATAGCATACGTAGCATAGCTGCAATCTGAGAGCTAATACCTCATTAGCGGAGACATACACTTCGTTTACCCCGAACACCGAGAAAAAAGTAGAATATAATGTGTCACAGTGCTATGCTATGAGATTGAGAAGAGCTTGAAGAAAGAGTAGCTGTCCCCAGCGGATAGAGAGAGACCGCCGCTTGTGAACTCCATATTGCACTGTGACAATCGACCAATACTTCTACCACATCAGCACGAATTTGCAATATATGGTCGAAGCTATAGGCAAGGACTCAGCATGTCACTACTCCAACAGGTCTCATCTTATAATTTTGAGGTGGAGAGAAGATGAAGCGAGAGGTACCAAGTACGTTTATAGGTGAAACGAGATGAGACCATGGCAACGTCACAGCCGGAGTGACACTTCTCGCCGCCCTACCGTCCCAGGTGCCTGGCATAAGACAAGAGTTGCTAATATACAGTAAAACTATATTAAATTCCCAGTTATGCACCCAGCAGATATACATGAACGAGGTGCATTCAACCTTGAGCGAGGATGCTGCGTAGCAGATCTCTGCAACCACGGTCTTTAGCATCTATCGATATTATGGAGTACTCGCAACGAGGGGCGTGGCTATTCATGCGGGGCGGAACACTCACTGTAGCATCCCTCCCACACACATCCGATCACCTTTTGTTGAATGTTTATAGCGTATCTAAAGCGTACTGCGAGATGAGCACACTATGAGATGCATCACATAAAGACTATCGAGGCTCATCATGACACTGCTCGACCACAGACTGTCAAAAGATATTAAATCGTTCAAATCTAACACCGCGGTATGCAGTTTTTATCTCATTACATCGAACGGCTAAGACATTGTCACACATATCTAGAAAATAGTCTAAGAGAGCATCTCCGCATACACGCCTTCTCAGAGTATATTCTTTAATTATAGCACTCCGGATAGAAACGGTCGAGATATCTCTGAGCATGTGAGAGGTAACTAGAAGGAATACAAATAGGAACATCTTCAGCATTAACACAAGGTCAATCCATGCATATCATATGCCCTCAATATGAGCAATCAACAATTTTTCGAAAGCATAATGGAGATCTATAATTTTTTGCTGAGAATGGTTGGTTCTCTATATTTGATTTCTTTGTGAGCGCCCGGTTTCACGTTAGTTGATATCAACTGTCTCCATCTAATATTTCTCGTTCAAAACTTCTAGTCCCCTATCACGCTATGAGTTTTCTAGAGCTAACCTAGAGGATGCACTTAGCGCTCGTCCATCCGTATCACTCTTGTCATAAGTGAGTAGCCAGTGGAGCAAGACTTTTGGAGTTGCAGACTGATGGATTCTAGTGGAGCAGATAACTTTTGGAATATGGGACAGTCGGTAAGTTCACGCCCCGAAATGCTTAACCCACTGGTGGCTAAACACGACGTGGCGCGCGCGCCTCCATCGGCAGGTTATCCTGTAAGCTTGCTAGCGTCAATGTGCAATGGCCACTATTTGACATTCCGAGACAGAAAAGTCCTGTTCCCCGAAGGGTGACGTAGCACCATCTCACTCTGGTGGTTCCTCAGATCCAAGATCTCAGCCAGCCTACCCAACAAATGCTACTCCACTGGTTAGCCAGGCACGACCTCGGCACGAGTGTGAGGGAGGAACATCTTTAGGGTAACCACACACTCCGGATGAGCCCGAACGGAACGGGGCCCGAAAGAGGGAAAGGCACGAATCGGCTGTCCCACAGCCCCTATCCCCATGTTAACTCTAGGCGTTGATAAGCCAAGCGGGGCTTACTCTCATCATACCAAACAAAAAAAAAACAAACATCAATATAATACAGGGAATGAAGCAAAACTGAGAAAAGATAAGCCAGTGTAAATCAACGCCACAGAAGTAACATGGAAAAGGGCGGACTAAGCCCCCCCGCGCCGCCTTCGGGCATCCGGTGTATTACCCACAAGAATGATAAAGTTGGTTTTATTCAAAGAAGGCGAGCTCGAAAGAAGCCTCCAGGCGTCTAGAGAGTGAGCTCCTAAGACGACAACGGGTGCGCACCTCCTCAGTTTGAGAGCTATCCGAGACACCCAAAGAGACAGAGCTCACGCTGCCCAAGCTCCTTCCCTTCCAACGTGCCATGAAGCTGCGATGATTCTGTGAGGACTCTGTGTACATCTCAATGCCGAAAACCCAAACGCACACGGATCCATGCACTGACTGGGGTCGGCATCAGGATCCTTAAGGGCACACTGTAAGAGCGTGCCTGACTGAACGAGAGCGACACATGCGCTCCGAGAGCAGACCACATGAAAAGTCTCAACGCCCAACGCAGCAAATCAGCAGGATAAGGAGTTTCCGAGAATCTCCATGCCTGGGCACCGAGTGCTCAGGAGTTAATCTACGTTCACCAGAAGATTGAATATAGCCAGACTGACCACAACCCACCTGGAAAGAAACTTCGTTCTGGCCCCTCAAACCGCAAAGATGGTTTAGTTTTTAGCAGAGTACCGGAGCAAAGGACCCTCACGACCCCACAATAAATCTACGAATTTGTAACTCAGGATATGGGGACTTTCCCAGCCAGACTCTCTCCGACACCAATGGCGGGAGCATAATCTGATAGCCCAGAAAACCATTCTGAGAGAATTACTGGGTAACATCGGTGTGCCCACTCCAGATCCAGGACCCCCAACCTGGCTTGTACCCCTCAGACCCTTGCGGAGCCCAGCTTGGACATCCCCACTCCCTTCCCAAACCTGGAGCCCATCGGAAACCCACTGAAGCGGCTGTGTGCCGGGGGGGGAAAGTGAGGAAGTTACGAGGTGACACGCCTTCATCACCGGGGCCTCCAACCTTCCACAGAAACATCTCCTGCCCAGAGCCTGCCTGGGGGGTCCGAAGTGAGACGACGCCTGCCTATGGCCAATCACACGCAACCCTGGCATGTCCCTGACAGACAGGGGATGAAAGCTACGTGAAGGCACTGACTGAGCCCGGGGGAACTGGCCTCTGACGCGGCCGAACAGCGCTCTGGGCCCAGGCTGGGGGCACTGAGGGCCACACATACATGCATGAGCGAGGGCTTGCTCAACACGGCATGCCCGATGCGAGTCCCCAAGACAAGAAGAGGCGTGTTCGACCTGTGGGCCCTTCATTGTAATCTGATCACCTTCACAGAAGGAAGTGGACGCTCACCACGCTATGCTCCTCTGTTCTTGTGGGGAAGTCATGGCCCCAAGGACCAGCATGGACCAAGAGGCTCAGTGAATGAATCAAGGTTGTGCCACTAGCCTCAGGGCTTGTAGAAAATCGCCCGGTAGGGTGCCTCCTCCTTGAAGGAAAAAGAGAAAAGAAAACACTGAGTGGACCTGCACAAGATTTCCAACAGCCACCCACCTCTCCTCACCTCTACCATACAAAGGCCTATCCTGCAGGACCTGTGAGGATATGATTTCCAAAGGCCCTGTGAACCTGAGCCCTCGCTCCTCGATGTGTGGCCTCTAACCTCACCACACCTCCACCACCTCAACCATAAACTGTTCCTGC 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@rCer/32/0_1390_CCS CAATGCCCAGATCAATAGCAACCTCTTCATGAGCTTGAACAAGGATGGTTCTTACACAGGCTTCATCAAGGTTCAGCTGAAGCTGGTGCGCCCTGTCTCTGTGCCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGCGGGGCCCCAGGACGGGCACAAGTGTCAGGCGCCGCACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTGCTGTCACGCACAAAGGCACGTGAAGTCATTGAGGCCCTGCTGCGAAAGTTCTTGGTGGTGGATGACCCCGCAAGTTTGCACTCTTTGAGCGGGCTGAGCATCATGGCCAAGTGTACTTGCGGAAGCTGTTGGATGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGACAAGGCCCTGAGCTTCGTCCTGAAGGAAAATGACTCTGGGGAGGTGAACTGGGATGCCTTCAGCATGCCTGAATTACATAACTTCCTGCGTATCCTGCAGCGGAGGAGGAGGAGCACCTCCGCCAGATCCTGCAGAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCCTGCCCCCTCGGGTGACCTCTTGTACCCCAGGTGAAGGCGGAGAGCAGGCAGCACCAAGTGCATGCCGTGTGAGTGTGACAGGGCCAGTGGGGCCTGTGGAATGAGTGTGCGTGGAGGCTCTCCTCTGCTGGGGGAATGAGCCCAGAGAACAGCGAAGGAGCTTGCCCCTGTGTCCACCTGTGGGTATAGCCGGGTATGGCTCTGCACCCCTTGCACCCCTCTGCCCTCATTACTGGGCCTTGGTGGGCCAGGGCTGCCCTGAGAAGCTGCTCCAGGCCTGCAGCAGGAGTGGAGCAGACAGAAGTCTCCTCAATTTGTGTCTCAGAAGTGAGAATCTTGGAGATGCTACAAACAGAACAGGGTCGCGTTTGCAGGGGTGAGGGCCCTCATCTATGGGGAAGGTTTTGGATTTTGAATGTGGTCTCAGGATATCCTTATCAGAGCTAGGGTAGGTGCTCAGAATAAGACAGGCATTGAGGAAGAGTCTTGGTTTCTCTCTGCAGTGCCAACTCCTCACACACCCTGAGGTCAGGAGTGCTGGCTCACAGTGCATCAAGTGCCTTAATGCCTCATATGAGGAGGATGTCCCTGGGCCAGGGTCTGTGTAAATGTGGGCACTGGCCCAGGTTCATACCTTATTTGCTAATCAAAGCCAGGGTCTCTCCCTCAGGTATTTTTTCATGAAGTGTATGAATGTATGTAATGTGTGGTGGCCTCAGCTGAATGCCTCCTGTGGGGAAAGGGTAGGGGTGACAGTCATCATCAGGGCCTGGGGCCTAAGGAATTGGCTGAATAAAGATTTAAAGATCC 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S-23/5:;::793/43710+759865;5563788/75/55/5/9583635:5:37,2*,/-12<9?=+63<4::6:;9>8<<=6658<978;;05/..1.5784799482086;90689<6*431362;;:>2<987;;9#4568<(:69;/>><$:85<75466$53;'587652450'249164<9985;3412<9>;76:8<8<4>=9876972.234247A;5=:>47?@>A=A?CA?@B=@?47@5@=92<3A?7<=.<<=0?>=3796916359713757<%0./47;::07><5;:4:4:98;87141.;92)99:2;85=6;443199<=57::6<6=725=7<7783994675146/;;6735.2,/977:33/<<=;/007838;7;54752=)4->5030:8<;9=3298<<;==6?=?31;6<:6)6767176;3:/639075735235079<6656533321,102052.-$+0-/10;<:<:=;783'88.272966=8:2-9==:;<959:989><<=:?3297;5*2@?<0=7'0:028;;<:=@BC,C9B5?9><=;15:<;8<92>@AB;8/5<;AA:B?9:?849,4:;=0<7$0;0.59?:;8>990477<@;5A=B?;;?<15357756:582(25:BA(75475;<(>466C>FC887666A;9@BD>6A9>6683=><1>A<9?473??>@895@<=/72,1:;7425<:?:72;<24/7<%>=7>?A=6.A@>:<<=.2//7<3;;C5BB<:-4<7;8=B8;'=?=?HBDB7DFDAF:?,AC@E:4E:BD=HG>D;CDHA>CC9GG@CHEBH?D@EF8FB6A@GCB85?EB:EBC9AFHEDHHD>3D@AE>DCE9/B/>9CBDA?=FC@@CCBC(@<>F0029;188=DGC97=A<>@;FGIGJF7=8>=B>=@=ECGE8IG>'8/0&@E?/3;3;7839;-6:,3;=A=<>=A2<8:6=D:@@CBDFE8&58D=A04<1,;=:84=A4;@98?,@@B7.35/77@,94<>47=:-6.;@??><>?=8;=7C2?A?@?>:@?=6;?;=:99AA1>=AB;==>8+-3??A=:A;B-?CA2=1767<9>C;@>7<:95746032687:<>=?=;=<<;*=@;@C=9?@'24;/&458>6;;:9,'399A>A<49145==8;/6=:=5@<.;8>1;8:?87=3=AA0:3)479;,55<05=@B>9346<4A3<75998=B5-8&;:A5@5:7?B695<96@B;?5?EA?@A@< @rCer/35/21_2228_CCS GGAAGTGGAGGTGAGCTGTCGCGGGCGGCGCCCGGCCTTGCTCAACGCTGGCAGTCCCACCGTCGCTGCCGCTGCCGAGGCCTCCTGCAGCCACCATGTCCGCTAGCGCCGTCTACGTGCTGGACCTGAAGGCAAGGTGCTCATCTGCCGGAACTACCGTGGCGACGTGGACATGTCGGAGGTGGAGCACTTCATGCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCACCCATCCTGGCCCACGGAGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAATGCGTGCGTGTCGCTGGTCTTCTCCTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTCATCATCTACGAGCTGCTGGATGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTGGAAACAGGGCCCCGCGGCCCCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTCCTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAATGGCAACGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGGGTCTTCCTCTCGGGCATGCCCGAGCTGCGCTTGGGCCTCAATGACAAGGTCCTCTTCGACAACACGGCGCGGCAAAAGCAAATCCGTGGAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAACGACCGCACCATCTCCTTCATCCCGCCCGACGGCGAGTTCGAGCTCATGTCCTACCGCCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATTGAGAAGCACTCCCACAGCCGCATCGAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCAATGATGCCGACTCACCCAAGTTCAAGACGACGGTGGGGAGCGTCAAGTGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCGGCGGCAAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCCAGCGTGGAGGCTGAGACAAGGAGGGCAAGCCCCCGATCAGCGTCAAGTTCGAGATCCGTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCGTGGGTGCGTTATATCACGCAGAACGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCGGCCAATGCCCCGGCCTCGGGGCTCCTGGGACACACCTGCCAAGCCTGCCAGATGGAGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCCGCCCAGGGACCCCTGCCTTCCCCAGGCCACCTGCTCTGCCGCTGACAGTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTGAGAAGGCTCGTCTCTTTGCCCTGAAGTCAGTTTCAGGGAAGGATGTGAAAAATTTTCCCTTTTGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGTACCAAAAAGCTTGGCCAATGCTTGCCAGCCAGCCAGCTGCAGTTGGCATCTGCCACGAAGGAAGCACCAGCCTCGCCGGCCAGCAGGGGCGTCATTTTGTTGCCATTTTGTTGAATGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCGTTCGTTGCTGTTTGTGTTACCCTCACTGTCCTATGTCCCACCACGTCCTCCGGCACTCAGGCAGCACTTAGTGAGGACGAGCCCTCACCCCTCTTGTCTTCCTCCCGGCAGCGCCCGCAGCGGGCCGTTTACACGTTGGGCCGGCACCTGGCGCTCTCGGGAGCCACTGCAGCGTCTGCCTGCTGCCTGGACTCGCAGCCTCGCTAGGTCACAAGACGCTGTCACTCAGCCGGATCAGTTATTGACCCACCAGGGAGGTAGGGATCGGTGAGAGACGCCGGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGCCCTCCCTACCCTGTGTGTGTTCACGTCATAGTTACATTAAATTCCATTCATT 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@rCer/36/0_1757_CCS CCAGATGAAGCAGCTTTCATAGAAATGGAGATAGAAGCTACCAATGGTGCGGTGCCCCAGGGCAGCGACCACCCCCTCGTATCAAGAATTTCCAGATAAACAACCAGATTGTGAAACTGAAATACTGTATACATGCAAGATCTTCCGGCCTCCCGGGCCTCCCATTGCAGCATCTGTGACAACTGTGTGGAGCGCTTCGACCATCACTGCCCTGGTGGGTAATTGTGTTGGAAAGAGGAACTACCGCTACTTCTACTCTTCATCCTCTCTCTCACCTCCTCACAATCTATGTCTTCGCCTTCAACATCGTCTATGTGGCCCTCAATCTTTGAAATTGGCTTCTTGGAGACGTTGAAAAAAACTCCTGGAACTGTTCTAAGAAGTCCTCATTTGCTTCTTTACACCGGTCCGTCGTGGACTGACTGGATTTCACACTTTCCTCGTGGCTCTCAACCAGACAACCAATGAAGACATCAAGGATCATGGACAGGGAAGAATCGCGTCAGAATCCCTACAGCATGGCAATATTGTGAAGAACTGCTGTGAAGTGCTGTGTGGCCCTTGCCCCCCAGTGTGCTGGATCGAAGGGGTATTTTGCCACTGGGAAAGTGAAGTCGACCTCCCAGTACTCAAGAGACCAGTAGTAGCCTCTTGCCACAAAACCAGCCCACAGAACCCTGAACTCAAATGAGATGCCGGAGGACAGCAGCACTCCTGAAGAGATGCCACCTCCAGAGCCCCCAGAGCCACCACAGGAAGCAGCTGAAGCTGAGAAGTAGCCTATCTATGGAAGAGACTTTTGTTTGTGTTTAATTAGGGCTATGAGAGATTTCAGGTGAGAAGATAACCTGAGACAGAGAGCAAGTAAGCCTGTCCCTTTAACTGTTTTTCTTTGGTTTAGTCACCCAGTTGCACACTGGCATTTTACTGCTGCAAGCTTTTTTAAATTTCTGAACTCAAGGCAGTGGCGAAGATGTCGTACTCTGATAACTGGACAAATGGGTCTCCTGGGCCTGGCACTGGTTCTCCATGGCCTCATCCACAGGTCCCCTTGACCCCCTCTTCCTCCAGATCCAGCCCTCCTGCTTGGGGTCACTGGTCTCATTCTGGGGCTAAAAGTTTTTGAGACTGGCTCAAATCCTCCAAGCTGCTGCATGTCCCGAGTCCAGAGGCAGTCACAGAGACCTCTGCCAGGGGATCCTAACTGGTTCTTGGGGTCTTCAGGATTGAAGAGGAGGAGAGTGGGGTCAGAGGATCCCTGGCCACCAGTGCCAGCATGCCATGATCTTTAGGAATGGGACAGGTACCTTCCACTTGTTGTATTTATTAGTGTAGCTTCTCCTTTGCTCCATCCACTCTGACACTAAGCCCACTCTTTCCATTAGATTATGTAAGCAGTTGTAGTAGGATAGCAATTGACATTTCTCGTAGACTACCCAAACTTTTTAATACCTGTGCCATTCTCAGTAGAATTTATGAGATGCCAACGGCATAGCCCTTCACACTCTCTGTCTCATCTCTCCTCCTTTCTCATTAGCCCCTTTTAATTTGTTTTTCCTTTTGACTCCTGCTCCCATTAGAGCAGGAATGGCAGTATAAAAGTCTGCACTTTGGTCATTTGTTTCCTCAGAGGAAGCCCGAGTGCTCACTTAAACACTACCCCTCAGACTCCTGTGTGAGCCTGCAGAGCCTTGAAGCACAATGGGAAACCAAGCACAGAGAGGCTCTCCTCTCCTCTCCTCTCCCCTGATGTACCC 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S%/,,,.1211***$))*-'(.+0-,(0/100(,-,++)'*((./&.*0-/0,.-2/-*'0*&(*,+-#(*++11./1,.*.012,'*'00.2111++1,/()+/-,./20+*&,+,&.,.1112((#$(,/--(*&/(0/'(32611)-.%41(46$0&+621.20+,0265152321,-.1(/1/.04*+303-,(53142-$.3/2%-./)3*%20.,5,1..3+/.1$/-,*-2.613410+4-*-*)+)&&*/.0011(/&$-,22.-((*+(+-)++02*-.$'*-4,002'6.1,))($./1.0,%.55.6'2/,,#-(*,.0-$+**)(-.-)./1.61/52/)./&,+&"%&%-)--01)0/-3*250+2/(0.3)1-0.0/564//*'1*&-/)%$./+/+-$*(',*01..*),0),1/../-1,0/)042--16//522/,++&'-)'3&,.3.1&1,-10,%'1+..-/,036*).+/,,1,(-++*-,($-112-%,./1/),%#)-21*1+1)....(+-162/+32&%$()5997.43.011%44376,31881,255/2381:638947/::94.--383+6333%'$%0.30%/458:81145,1602..-*-%/-221-7231-6202*4.8148''*&#((#$+()$.((-(0*-&'12.*+&),$.01-)-,/)++-)../((+&+)+22+,,332+/3/4434032.0112/351$,-0.-/+-$(.&-**(1:08+3-2023/)/71774%,./--16980309=:?;?76:98,5::41;;,21(47-6)//156/2650350.)-4706499/57*4/00))+4/72444/61(2/1,9:9/84&,279,4/(461.53015.60/.04,.$&253025/59/60:9964)(6263)+*7963414771&154.54555'14,24-%7&-,-07;97:.65,9/%+2)1,.),")#'/0./2225'1-6./+21-#322,301,$4$&*-#)/17203'3&10+.527&1-+.,'-1(-'42,463-*&.&0,/$$('3',-.,,%.,(4.3'1.+*3(35/5(/-,21+,.494996,(4-%&03/13&413/*71210&*235*41,2/2-*#*.$3,,,.,23)3375-3(3/+35/,4/0/0-%.'67710./05,214,&)//&10-,4.2.142)+5.53&0*877455;9.355/53.50/**/++/303+%3/13222-3:3'(&'968$2/,*$+-.%4564''1+4294*3%$*/.13*36,51+*0/21-2705*5.)467&560.%2*520-4654**-/938.5*42-"+&1$.36120/-421*#$$/$#)(+1,$#00$7/38157'#,.08'02++0/3600*,0(%+)(2.,/*86-+)0187/53'*/321.',&#%-/#*/,%&)*+%*-+)2+236:2-10-,'+.2-/2.-14.222.4.53%.-563,'635;8498-.0-'*,&+3/3(6/0//6,18/75652)-997*9:709,.08099:6240+4-11/3043465%340//1(/,3851*7*&12435'4475:24./1598-30(3545-32203:2985584-3-2896;0*'(/403/303(/2451-*)&+,,//++).'1(-,(/01$'12/*.//(.-,4.00#20.$,1/6,'13(223$1*.55254,44/54+1'-2030*302455&)*0/1*$021)32 @rCer/39/25_1934_CCS ATGGGGGCGCCTGGTGGCGGTCCCCGCGCCGAGACGCCGCTAGGGCGGGCGGGGGTCGGGACGCCGGGCTGGGGGCGCGTCATGTGGCCGCTCACGGTCCCCGCCGCCGCTGCTGCTGCTGCTGTGCTCAGGCCTGGCCGGACAGACTCTCTTCCAGAGCCCAGAAGAGGGCTGGCAGCTGTACACCTCAGCCCAGGCCCCTGACGGGAAATGCATCTGCACGGCTGTGATCCCAGCGCAGAGTACCTGCTCTCGAGATGGCAGGAGTCGGGAGCTGCGGCAACTGATGGAGAAGGTCCAGAATGTCTCCCAGTCCATGGAGGTCCTTGAGCTGCGGACGTATCGCGACCTCCAGTATGTACGCGGCATGGAGACCCTCATGCGGGCCTGGATGCGCGGGCTCCGGGCGGCTGATGGGTCCCTCTCGGCCAAGAGCTTCCAGGAGCTGAAGGACAGGATGACAGAACTGTTGCCCCTGAGCTCGGTCCTGGAGCAGTACAAGGCAGACACACGGACCATTGTACGCCTGCGGGAGGATGTGAGGAATCTCTCCGGCAGTCTGGCGACCATCCAGGAGGAGATGGGTGCCTACGGGTACGAGGATCTGCAGCAGCGGGTGATGGCCCTGGAGGCCCGGCTCCACGCCTGCGCCCAGAAACTGGGCTGTGGGAAGCTGACCGGGGTCAGTAACCCCATCACCGTTCGGGCCATGGGGTCCCGCTTCGGCTCCTGGATGACTGACACGATGGCCCCAGTGCGGATAGCCGGGTCTGGTACATGGATGGCTATTACAAGGGCCGCCGGGTCCTGGAGTTCCGTACCCTGGGAGACTTCATCAAAGGCCAGAACTTTATCCAGCACCTGCTACCCCAGCCGTGGGCGGGCACGGGCCACGTGGTGTACAACGGCTCCCTGTTCTATAACAAGTACCAGAGCAACGTGGTGGTCAAATACCACTTCCGCTCGCGCTCCGTGCTGGTGCAGAGGAGCCTCCCGGGCGCCGGTTACAACAACACCTTCCCCTACTCCTGGGGCGGTTTCTCCGACATGGACTTCATGGTGGACGAGAGCGGGCTCTGGGCTGTGTACACCACCAACCAGAACGCGGGCAACATCGTGGTCAGCCGGCTGGACCCGCACACCCTCGAGGTCATGCGGTCCTGGGACACCGGCTACCCCAAGCGCAGCGCCGGCGAGGCCTTCATGATCTGCGGTGTGCTCTACGTGACCAACTCCCACCTGGCTGGGGCCAAGGTCTACTTTGCCTATTTCACCAACACGTCCAGTTACGAGTACACGGACGTGCCCTTCCACAACCAGTATTCCCACATCTCGATGCTGGATTACAACCCCCGGGAGCGCGCCCTCTATACCTGGAACAACGGTCACCAGGTGCTCTACAATGTCACCCTGTTTCACGTCATCAGCACCTCTGGGGGACCCCTGAGCCAATGCTGTGGCTCAGGCTGCTGCCTGGGGGGCCTCCGGGGGCTGGGGGCCCTTTTCATTCTGCCTGTGTCCCTCAAGGGTGATCTCTCTGTCTCTGTCATGCCCTTTCTCCCCGCCTTTTTGCTGGGCTTTTGTTCTCTGCCTGTGTATTTCTGTCTATTTTCTCAATTTCCCCTCTTCTCCTTTATTGATCCCTGCTTTTAATACACTTCTTTCTTTCTGCCTTTTTATGGATGTCTTTTTCTTTTTATGGCTCTGGTTCTCCAGTTCTTTCCCTGTCTCTGCCTCTCTCTGTCTCTCTCACTCTCTCTGTCCTTCCACCCCTCCCTCCTTGCTTCCCACCCATTCCTCATCCCTCACTTCCACCCCCACCCCCAGGAGTTGAGTGCATGGATCTGTTTCTTTTTTTATTTACACTTTTTCTTTCCGGTTTGCCGGAATAAACAGGACCTTTGACATT 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rCer/41/25_1680_CCS ATGGGATGACCTTACCTACATAAATATTTATACTAGCATTCACTATCTCCCTTTAGGCATACTACTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAAGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTTCCTCTTCATAACTATTCTCCTACAAATCACCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACT + *-,2,.(/*(.)---*'0111&..*(#&(%%'&(,/,./.-'%)+,)+)0,(-$*$$'((&*.&%+&%//,.+-+-(*+,).1,&,..0%,501/410/0**.$1,*3543#.*36:835-022&5648%1'06%35378(('%-32+30%*/./01&01:::728;061:40(2//0.4881-4-3/=:47-7:96:;>8==1=9;78.3978::98<=*=:>8?>1685249<<9:;;97;9?/>714(/;9744<<4=>9;:*>>=:5(6586++$8)503==;;85754.7(57812;9-:77782*0-28;7:67?=9>3?8??>8;;>6;4:?;::8:8370745//?19692;=79+<=;.7;'988==8982876?3+;09/<:461:864>'8/=7(3<3,499;57;3<4=78997:6'920=:<,=<525.:109<8*;194.8/,=635(2>=969:4;4/93>91$941637>9,1.(,9=5>76>6,6(1502=:)05>;5;9,=$67830'.-1+>;;,*;2-*009;=0=18>7>9::887<.289./7;87.*56'47395672;03&,/13:=>6<:>=>=9>3>:<9-<;=6;61?>>=:??7/>=.=:.::;;;9;2=>8-=>7'878;8::>:8>::3;==;<:8=/<83.=:<747<:>1<:>49=::613=5=*=;-,)46<=20/384;3A=;5?<@>?@;*+<>?:6;;9,88.7028&;;4>1(;+447,3?4->61==7A8CC@B2?>?=7;;A>2:>@6?@;:BB>9C5@@><<52:9.A@18==A=+?<:35<@B>:8BF=;@9<@&9AEE7E+F><,8:B+BBD@CA6D;=@?5&9/D5DA===7D9C?;B5?A4D>+@B@)AAADD=;>9?4/=ED6C0CE=A2C9FA*A==>5@9/EB/729<3>8C?9D?.BD?99C,>B2?6;:D1F/A99A;@A?E9;D?C>%:-48BA?3D'D?<);4CC=AB?C@8/B9B=8C;#955?A?8?>@6B8EGE295AC=BDFFDD5EDAEB@D@DB8DE9>8A@A=BC>=?B3C49CCACC8>'D:A;?;G9CC@B@)B@)B;;@FCFE@BB@>*A?;;97*;;85A8@9:4:;64<18=:F@F@AF(D0==->>>A:>A7GAC8:9C.:4(=@BF59=>5?;A71@1>;.??::,;@BA?B*A43<9:?:?D8B=18:C95@;?.CB7;,C=AA5=<1AD:E4E79DBF:B81=?9;B7E=D6?D>FE?BC/?4<A<2?=;9DCFF<=?5A5/2;D=E:=:C?9@B4A57;@A:-,<1;573>::;/5863=<.'43@<7=->>B5?@?5=:AAAA=E@:?@@C?AB6=F@=BDEFCA<>A@B-C=670:AC)B>>CDAC@CD=C9AC*FF>=>=;@D:5;3?>?B9CCB=D7BDA<<=BDD@A(>=@@?:F93B>A@8C>%A@B*B@6*02)==/2+785(#)496@80(/62&/;7(5AA8=69(4%68<:=9$*.5-84&0&/=@6>B?A12A@7???=;3-?5.@2,-'(,:13+:&>CB=3?9@47,7C,.97>37C0836;3.>=><<9#55:@A<3?672+;*7/9.&8/??%>?>'A@A1C=A6)6;?76981DA;7.C71;F:G>/E<';74.35AC:6/.+1859>?<.%1*90'AB,A@>@=>3DD9B'-%50C161B3C1@=:0C/-B=7>CF?@(@:(':-><',;630%;556,B)0&C.8C5F;BBE,<)>A2'9*E?957/8:4"#B8<&>63C&@<2958689@=51'0&6.484>;?95/@17?6>@AD;7>.(*->A8B2@+1*@6E<.<3?(49E9(B,>(=@:;:DDB/4$?>:.1+/AE?3*%621@0;=D2(.&4C0B:EG8*05@>=6':@C(E46<=BA9:)B9BC'1#+4A08>@2B@1G@E4E=B+;=9>D?0+>/?2/E'>:3G+68&=,<-?-:;?;C@G9E.'CCE%&'/A+CB(E>';'>:*2''5*&:5(.)>;:*1+.1@5=+8A,*)+;7'3-4=9A4;B<7<41$%0.+67%==@@C.*0?:.(/2,7,#7(188/:$2+-56&2>C?+=+28+>(&1<>-@=;'%1;$1-78:6'<%(92'@@9;):;>97-%)47&1+>?50:9/3%8@-86:';7?3/4671.6@5272;8&4045:-3(#,#))63'52+098)$/$4;=9(*/=>=93>2/4,9;;.;-<>>>=1?;7<<:2>6498<629237./6*>>=3'9/65&),9,($+.,)+4=38+==<.2*1#263<9;+54;<);.+;/1751)7(.,)*(*(3'$++8<175(:2242/:9-&)1<*,%/276:%<;+;87=0>.B/24/;8.<<,,6$:20;?5?/+A+?*)0+5'63=4517%)-;188%#3//7-&=908<-65::3>A);<:2+02:774(48)823;.>;A=:;6<*==:-$363<.ACCB??BCBB53BA;/8A//A69B>)>:310@181%994*=;*33).<5'.59;<>*;4@)=+;<1(9%73?3<.A8-5<+>99=9%::9'-<)%505)<12)>'5;&;>,@/5-=/+&7@<.=1(;2<55.;CA/@7'.1><@+>40,%$5:=;6;7=&;=<%<149?>91'7'.64,*'7791=++.4*3?@@0 @rCer/48/1917_60_CCS ATGGGAGCCCGTCCGCCGCCGCCATGGCCACCACGGTGACCTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATTGGCAAGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATCTGGTCACTGGTGGGGAGCTCTTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTCGGCCTGGCTATCGAGGTGCAGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGATATCTGGGCATGTGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCCGAATGGACACTGTCACTCCTGAAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGATTTCTCAGTGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCCGCACCAGCCAGTCTGAGGAGACCCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGTGCCGTGTGGCAGACAGCAGAGCCTGGGGGTGGACGGGAGGGGGCTGCTGAGGAGCTGACCCACCGCCCCATTTCAGAGCTGCGCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCGACTGCCCTCGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCTGGTGCCTGTGTCTGCAGAAAACAAGACCAGATGTGATTTGTTAAAAACAAAACAAAACAAAAAAACAAGATGACGACGACACCACAAAAAAATTGACATCAGATG + ICHG/HAEK=:6K/9J9JKF=C8:@IAC+JA7DJKKKKJKJ?JKKJK:JIKGKHKKKKKKGKGJKIKKKKKGJJKKKJGJGK0K>BJA>?@D2KICGJJKKKCK6HJKJKKFKFKKK.K?GKCFJGKKKBKKGJIEEGIG?K1FGK@JKJK:7JBHHIKIGKJKEK.GD9IJKKKJJJKKIKKKKKJKKKIKKKGKKK@KKK/I@:I8IKEKKJGKKIKKAJKKKKKKKKKKJHKKJ:IKKKK.IJF=>%IKKFIIIKCGJJ/;KCKFIJKCK?IKKGKJKKKKIGIKJ@JJKKKK=JIK+KDKKKKHGK?FKJK>J@IKJKIKKFK?KKCKJK@KKKJDKIKIEEG-EKHEFKDK6JFCK.KIAGJB?=>HJIJ>>7CGK8HICJJJKHJKKJKI&GKKKJKKAK0JKKKH-I>K:GKI?JKIKGIJKK.EJK>GKKKKKKKHKKJKKKK/KJKEI@KKGJDJKJIKJKKKK:KH9KEJKK?KII9K7D4KK3KKI@KAGJ:CHKKKKBJGJJKKJ6KFK0K6KKKFJHKDFKK7@K&KJKJKK&KKAKK2JK?JKKIIJGJK>?KKIFK-KKKK*KI3KH2HJ@JJ)>>GKKIKF7IEK*DBBD=JHC@=GCJDKAFGH?HFGK3JFEKK>3FJKIJDJBKKIKBH@KDHKKKIHKHKKJKJKGIKJJKBHHDK>I?KI*KDKKBJKKJKGKKKKIHIGEIIKKGKCGGH>EIKBDJ9IKKKKKKKCEIJJBFKK>HJJK@?GJJHJKCKKGBKGJKKFKKFGIBKAH=@GIHK>9JKHJCH(BEGK?@JKIJ?KKFJ?JBJJHHJ4JE>>?=IAKJKDEJ?IIJ;KJG@JIJAKK-G=IHJB5IA>BE(I?IJKJJ-8=C$9GFFIKGKJKJI7IIJKKKACGKJAIDHHFI=JGFHJB:K?67HI+BK?IHJ>HKII>GIKCHBIEI)KE>@FJ6JHG9FF=GHH7FI$$@AA%IHJI+JJKF'FEBJEJK/AJ1JIIGHJJGD@G@&64IGHIKKKK(K0JKFFKJEGGKI @rCer/52/25_1722_CCS ATGGGGGGCAACGGAGAGAGACTGCAACCTGGGTTCCGGAAGTCTGAGAGCTGGAGCTTTGAAGCCACCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGCTCAGCGACATGTCCTCACCTACATGGAGGATGCAGTGTGCCAGCTGCTAGAGAACAGGGAAGATATCAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCAGGGAACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGAGCCTTCTGGAGATGCTTCCGAACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCTCACTCAGAAAGCAGCCAGGATTGTGCTCATGGACGACGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCAGTTTTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGATCTGCTGTCGGGCAAGAACCCCAACACAGTGATCGTGCCGACGTCATCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGAGGCCGGCATGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCTGGAAAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCGACGTTCAGAGACTGACCTTCTATGGGTTCCTCATGGCTCTCTCAAAGCACCATGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGATCTGATGCACGACCCAGCAATGGACGAGGAGCTGGAACGGCTGCTGGCCCAGGTCCCGGGCCTGGTCAACTCGATCACAGCCAGTCCAGAGGCCAGTTGCCTGCCCTCCCGGACCCCTCCCCGGGTTGGCTCCCCCTGGAGACCTCTCCACCATTCCCGAAAAGTGGATGGAGAGAGCGATGGCTCCACTGAAGAGACAGACGAATCGGAGACTTGAGGAGTCCGAAGGGTCCAGCCCACAGCGCCCTATACCTGCTCCCACCCAGCCCTTGGCGTGCCCACCCAGCCTCCTCTCCAGCACCTTGTTGTGCTGCCCTCTGCTGCTGACAAGGCGAATAACAGCCCCAAGAGCGGCCAGAGGGGCGCTGATGATCAGCCCAGCCAGTGGCCCCGGAAGGGAATGGCCTGCTCTCCCTGGTCCTGTCAGCCTGCGAACTTCACTCAGGCCCCAAGCTGACAGCCTGTGCTGAAGCCACCGTATCACTAGGAAGGGGACTTGGCCGTAGCCTGTTAGTCCTCCTAACCTCTTAAGAAGAGCGGTCTCTTCTGAACCAGCCTCTGCTGGTCCCCTGATAAGGTTCATCTCCTCACAGCAATTCCATTAAGGGGGAGAACCCGAATAGCCACGCAGGGCCTTGCACCATCAAGGGTGACACCTGCGACGCAAGTACCAGGAGGACATAACCGCTGTGGCCTTCTGTTGGAGAACAGCCAGTAGCCTTGGTAGGATGGAGAAGGGTGGGCCAGAAGATGATTTCACTTGCAAAAACTGCTTCAAGTCTTGACCCCTTTGTGTCTAATAGCTAAATATGTGAAACAAATAAAGTCCCTCGTGTCTGG + ID/EGJCG?>FE;BF?CIA?9IJHHCH>EEDJI?IHKCKCJIFFIIBJKJJDJKHGE3FIH:IH>H>$IFEEGF9IJHH>GIF>F<6F1EAFKBKGH7CE;?>?@C9AH@GEJIGHCJI?HFHHEJIKJKKGKJIJED=HCE&BJ?;EKHJDFD>FFIKEGIKHDFH0=IJIDH>G>?IHIJ7IHGJHKIKHEJH5IKIIKGKGJ>JIIEIG>?G?E@EEHHHGFIC7E@@HHCD@DB?A>CFFD??B>D<=AGCGGFG=CFC7>E<'@9CACHHF?D?EIFF4ECD?IEGCFCC<5@DC<.?ABEEGC::<@ABF?FCEDG?CBGE;HIGDH@D8G>>A8DIEBFGHHG7DBADHE9H?;8<=,F8CED7EGH?I9=B>BEDJFCDBA@<4<4B6=FIFHFJAI,F:A??ECAAEEDBGD@GHA0F=G??:C>EAGDHEBG(:@<<9EB;EF?9;A@FDH3=GCD5DEA4CC?;2:>?=DJGFE:FAEGFGFJFGECEI@JC9HEJEF8;EIEC@DF8D9GEHHH>KC5CJIIJH5<8EGKKKKKCHJK<>I3GJ7FIJGGB@:$I@FCGJIJFEDIEB?9IGAJFIGEKEIJ62AEFDDBI>HGIKFKHHGKJGIFK9IF@7HK8G>0IH@:/AIJ>GA8HGCAEAGJEJD?@BKDJ4ID?HJCKIK1K8CGIHDCA86HKHJCH>HGA2G=HGAKJH6KC6:5>AKFGEE@KKFAJKHG8KD=>;I?>,E=FHFD?G;>9D@ABECDCHFHG;JJGEGEGJCII@F=JFDI@CEEHAI@GG;JGHJJ;IB6J?>I;JKKGKKHIF@I2GGIG)IFFIHEF7E7HB9CJK?GEEJEKAFGAIAHGI4F:HBJK?IBFJCKJG>?H6=IFGCKAFKGA@FDJFI@HHKCFIGKF?AHFC7B:FJG=JEDA8JEDGH?JAJGCFIFBJGCJIGIHGJIJ82G9E>?IJ3JGHHFJEEDJE7H5?CGIJKKGKIHG5??II*EBFJB@CHCJIIKIIADGEFAD=AAB>FJ9EIA?AK;=FI?JK8HCICKFDHH4>BGGIJFHIE/DEJIJJHGJKH;KJHKEIIJ=IKJCKJEJKDFIBEIJHF,:BIIF=CC1:FII6JDG4EKJEFDF7JKG2KJDKIJCHCGKKHJHKKKKHDEIKHKJIJIKJDJFGHKJJJKKKJKJHKKKKKFJDH8KD2KF8KKGJKIJKKJGCI7IKAKIKIKCKJEJGKD;HJJJI@KJK?KJJKDGCJBK:JIKKKKJKKKKJHKKJKKKJH8JDIC>;KGHKK8KKFJKJGKKKKFJKKKH@5KKFKJCKKKIKKHKIJHHEGGKJJKKEIKDJHIJJGH:JHIDKHHKKKJ&KJKDH:BFIJKIKKJJAGIJJKHDFJFKBKKKGKJ?KAKKKIFKJJIGIKJJ;JDKIGCI>FJKKKFDKKJGKCKBK)KKGFHHKKJKGKDKKKKKJJIJKJIKKJKFKKK>JJKKJIK7HIGBCHGJHJFG;KKKKKJJEKK?KJJBC&JGEJFKIHH0IJKIKKKKFIHJIKKIIFHGKFJJJBKJKKJKKKKKKJJKHI?KKKKHKKK5I7KKKGKKIGHIDJJEKKGKJGKKJKKKCKKKJ8JH1HJJCK2KKKJJJKKKGK4KJA8KEHKKJDKKHKKKBIIJKGFKKDGJ:KKKJKCJKIAEJJKJK=KKHKKKKKKJKEEE:JJKCKKIJJK&KFIIDKKJHJKDKDKJEID@KK3KFGEKKKKKJHKKKJKKKKKFKKKKJGK@KJIHJEJ:KIKAJ4KKKKH3JEKIHJK?HKJHHJKKFIKHKJJIKKKKJJKJ0KKKKGJJJKKKDKBKKKGFKJKKKIJ?JKG?GG@KFGKKIJCKJFKJJKIIIKJH=KKEAKIKKKJK;IKJCK:KKKKKKKKGKK5KKIKKGIKKKCKKECKKKB>HKIHJ9KJKKE?GBIJIKKDKGKJKKKK5KKKIIKKIKCF>KJJJJJHH;JGKKKKJKJKKJJKKKHDJHJKKKHJJ8JDFGKKIK;JJJJIKKKI+KKIIHKJGD:KKKHJKJE6HGDAHIIIEJK=JKK8KKJCII9JKGHJI2JKKKHKEKJKKKDKCDAFIKJKKKJKJJKKKK5ADJKJ@KIJCEK8JKEJ?JJKJ0GKKDKIEKKKJKII?I@JGG?GK@DH@C,IG>AD3CKBBG4HJK=H;DKGDI;HDAHIJJJBKHHCCBEGIHDIHJFJAHHBJKJ @rCer/54/1565_61_CCS ATGGGGCGTGCGCCCAGAGGCGCCGCGGGAGGGGTGTTCTGCGAGCTCTCCGGCCGCTGCCCCCGCCCCTGCGCTCTTGGGCGGGGAGGTCGGAAACCCCCTGGCGAGACCACGGGCGGACGCTTCCCGAAGAGCTGCCTGGGCTGCAGCCGCGGAAGCCTCGCTCTAGGAAGCGGGAGCGTGCTGCGGCGCCCTCTGGCCGCTGCTGGAAGCCGGAACCTAGCCCGAGCCGCTGCCCCTCACCGGACGCTGCGCGCGCCACCGGCCCTCCGCGGGGCAGGGCTGCTTTGAGCTCGCCGGGCGCCCTTTGGCCGTAAGTCTCACCCTGGCCCCGAGGCGGGAAGGAGTGCGTGCTGTCCCGGCCAGAAACGGCTAAAAGGAAGGGCTGAGGGTTCTGTGCCCAAGGCGGAAAGCCGTGCGCCAGGGCGGCCCTCAGCGGAGATGCCTGCACGGATCCGGGAGCGCCGCTCGGGGCAGGGAATGAAAGGGGCGCTTGAGACTGGAGATTTAGGGAGATGAGTTCCTTGGGAACAGCGCTGAACCGTTTCTCTGTCCCACCCTACCCCCCGCTTATTTTTTTGAGGCAGGCTCTCGCGCTGTGGTCCAGGCTGAGCGCAGTGACGCGATCACGGCACATTGCAGCCTCGACCTCGGGGCTCAAGGGATCCTTCCACCTCAGCCTTCTGAGTAGCTGGGACCACGGGGATGCACCACCACGCCCGGCTAATTTTTTTTAAAAAGTGTTTCCGGAGATAGCGTCTCGCTGTATTACCCAGGCTGGTCTCGAACCCTTGTCCTGAAGCGATCCTCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGCGCTCGGCTTTTTACCCCTTTCTAACGTTTTCCATGCCCATCGGTGCCCTGCCCACCCTCTCTTGATCTCTAACTTTTTCCTCTGTTTTTTCCTCGCTGAAGTCTGTTGGCTAAAGAAAATTCATGTGCAAGTTCTGGATGTGAATAAAGTCCTGAGGTGTGTTAAGTGAAACTGCTACAAATTTGATTTTATGGACTGCTGCAGGCACATTGAGAGGAGAAACGTCAAGTATACCAAACAACCGTTAGTTGAGAGTGGTGGTATTCGGGTGATTGGTTGACTTTTTTTTTGCACTAAACTCTTTGTAAGGCAACATTAGTTGAATGAAAAGAATTGTGATAAACATAAACGTGATTAACACAGAAGAGGCAAATACTAAACAAGTCAGAAGAAACAAGACCCTCTCCAAATAAACAGTAATAAAAAGTAACTGATTTATTTGGTATCCAAGAAGTTACAATACTGCTAGACCTAATAGAATGAAGAGATGGAATGATGTAGGGAGAAAGGCTCTGAAATCACAACTGGTTGGAAAAAAACTTTAATTGTATAATCTTATTTGTCACATCCACCTGCCAGATGTAAAGCTTATTGCTGTTTGTGGAGATGTGCAGACCAATAAAAAGCCTATTTAATGAAAGTATCAG + KHKKK/KKKKKKKKKJK>KKKGCEKKK%KHKHKKKKKKKKKKKKFKKKJKGKKKKKK7KKKK@GKKKKJKJAKK=KJKK=JKEKKKCKKJKKKK7JKKKKKKKK;KKKK-KKFKKKKKIKKJKKHKKKKKKKKKKKFKKKKKKKKKKKFK>IKGIKKKJJKKKKKEHHKK&GKKKHKIKKKKKKKKK7FDJK:KBKKKKKKKIKKKKKKKKHKKIKKFKKJEJKKK=KBH:KK7IKKKKK(KKKHKKJKK1KHKFJKIKKGJKJKKKKKKJKKKBKKIKK0KKKKKKKKJJJHKKKKKIKK2JKKIKK+KKKKKJKJKKKKKCKJKKIKKKKKKFKKK4KKKKHKJKKKKKKKKKKKKKKK?KKKJKKKKKKKKJKKDKAJKKKKKKKKGKHKKK9KJKKKKKK>HKJ%KKKKKKK2KKKJKKKKKKK8KKKJKKKKKKKJKKKKKCKKIIKKKKKKKHJKKKKKKKGKGKKKKKKKKKKJKKKKKFKKKKKGKKKKKCKJKKK%JKKKCKKIKKKKKJKDKKHKKKKK@KHKHKKJKKKKIKK+KKEIKKKK-KJHKJKDKKKKKKKK7KEKJKIKKKKKKK1EKKK'KKKKKEKJKI@JJKJKKKKKKKKKKKIKK:KKKJHKEKKKIKKKKKKJKKFKFKKKAKKKFKKKKKK?KKKJKKEKKKFJ-JKK1KHIKKKKIKK/KKKKKKJ>KKKKKKKIKKFKKKK:KKGBJKKK1KKKK+KKHKKKIJKKKK8K;DKKKKJKIKKJIKKJ)KIIK$AKK3FKKJKKKKKKKKKKJKKKKK8KKKKGKKKKKK3KKKKKKKHKBJKKKKKJKKKKKKKKKKK@KHKKKKKKKKKJKKKKKKKKJKKKIKKKKKKKIKKKKJKKKKKJKKKKKKKFJIJKKFKKKAKKJKJKKK7KKKJKEKKIJKKJKBKJKKKBKHGKK:K:KK)KKKKKKKKKKKKJKK1KKKKKKKIKKKJDKKJKJKIKKJJIKEKJK6KKKKJKKKJKKKKKKKKKKK6KKKKJKK@EJKKKBKKKDKFKKKKCKIKKKIAKKKKKKKFKKKK;KKFKKKKJJGKKK=KKKKKKBKKKKKKKKKKKKKKKKCKKKIKKHKKIKKKKIKKKKKHKKKKKKK4KKKKKKKJKKKKKKKKKJJKKKK>KKKAKKKKKKJKKKHKJKKJKHKJKKBFKIKIJ7KIKJKKIKKKKEKKHKKKKJKKKKKKKKKKKKGKKKKKKKKKKKKKKFKAKKKKKKKDJJJHKGKJKKKJKBKKKKKK(KKKKKJKKKDGI=CJKKDIKKIKKKKKIIKJJE>JKKKKKKKKHKKDKKKIJKKKKJKKK>KKKIKKKKKKJJJKKKCKKKKKKKBJKJKKKK+KJJIKK8KKIJKKK @rCer/55/25_1759_CCS ATGGGGAGCCCCAAAGGGGTGTGTGCCAGCCGACCGCTATAAATAAGGCGCCTCCCAGTGCTCACCACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACTCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGACCAGACGGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAATGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCAGCCACTCCCCGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGT + CC*IIDFF1HFE8G=0ECECAEFCC@FAE>GI:9?:BA=896FFAHBIF@CJ?1DDGF@G?CA;BEEDFCBEGEDFHCH9DFGEIAEFC@AC@FEEB>H=A?GEH8HG@:=EIGCFG>A?A2C;BA3EC>EBCAA2@B7C8DABC;F9>A6D>9B1;>DEAEA0@>8CDFCEFFCBF:D8A;>4<=A=>6+CE8(7A7FDD='A:AAFA?=EBCE=FEB8D=?FF>>?A($7<4AB>@?>=7<$<7?;@6A=B;;&<&?<:8<:;BA=9?6C97)-59?@B<5;CAB0BAA@;>7=;>>@:@5A83@AAB@=?<<5;29817?>:<8=A??BBA>BB@:=?==?B<636=B0BA?7=8A*53<>9/9==?C>A?CC@>=C?CB77988:%9<@@:;7.4;:?@A=:A?C?@:9::>69@;A@7:8:;>;2??>C>:;9:;>56?89>:@6:;6>8@>=BC=A>B@C?B>;1.4;9<<-@7BC;8(>@@CB=&765;77;+7;=<>BB=@:>>=;CAA=A@@@>&@76=><>@C/=1BC@7=<9>?6B@B?35>?C<8>@4?@-CA><=07:AAA927?:B?BCA=A=?>;>?9C@4A=@5.2@?<@7CBBB6864@C>;>;>@A>C;2?6:=?9;+<7;)=6,9:;B54>@8CBB?>.A@>?A?:@<>=B?;-BAB@?>7@4CAC,BB::<@:>9=C9?89A?C@B>A>?7A?AA:<>;?@C7A>@;*B6B?==9B???><3>>88?48;;A:E=DEDC7=@8??<==;<;A>@>@5A@9=8C/A@3>';::9.4:8=C?>@B?C9BC?CA1B@=9=@=B:8?7=:;B=?;C05B>A?A@A?B>9@5@BB?CB<;/?A@B<4@AC>2AA9?A7@>=9BABA:?8>:?A@@7>4?:?;>=@C@=A:@@B<;=:<>6?:??-7;:@ACA?3C<48AB+=57<@2@AA;B>>@63@A'9<@9:@>4==C<:1?703==4A<>A<822:;9?@BB;:;7??A7;:<4@4@?79186B@:<>=>B=AAAC6@9?7A9>9?5=B<>>A><5B>@@?CA@B3@@>A=;?=B==B@7?;<'<67:=>AC@>A6B4BBACCAB?47A79:BA>CB6@58/7@8=A55B83AA?=BA>>@4>?@-C@<@AC@>@BB>;@A.@=:>0>@86BBB=?::B6>B1C=:CA5>=:AA:31=@?972??A91;;:B>BB8A9?:+659676781;5>BB>?:=:@:5;%<;4$79.6':<<:47=7???A=?::@==>:)1B@:?8)9A@66'70.774A89>3<9:=:=;A=?A>;=<>9;;4>5<<3;6+>;=BAA@=%37988=9:> @rCer/59/2155_53_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCAGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCTGAGCAGATTTAGCTGGGGGCCGAAGGCAGAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCAATTAGCTGAATTCGCGTGTGGCAGAGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGTCTTCCTGGAGATTTGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCACAGCCGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGTAGGAGTCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCTAACACCTGCTGACATCTCCTTTTGCTCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAACGCGTCTTCTTAATCCCACTCTAATCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + 32:A:5@=190D>=A?87F9DGGFAE@KJGK:KKECK36>*D;E.CB@J=65CJHG>=EJEFGHKK;DAC@BI*5+<&:7GJA4G<>$?IE0J?E+@&?G>)I=DG/=9=F?DC*,20.EJ:F@2=@B)IB:/E1KG;<&E8;@DEB)5A+:@>BK;CJDGF48>I4K?J@9@E@E9:CD?BGB,4)$AGFEC3C;I1HHAJE8EJ@FAB/EFKJGGK>GEJJECJHFABDC'AGEHC1D.@EEG=IEIBBK0DHIAHHHKAJ?A.H=AHFKH.I8DHE?F@FJ>JDBG.EDHIEJFDGC=G;A=>9;DI8JIJJ3@+C17/0IHF69I(BAAI*IIKI@:C85>D4FA;@>IAKEJ3II?@@0FFK3K+I1BC=K>KKI@JK&KHJKI)KKJKGKKK?KKJKJKGIJ,HG>J9>:I7K1AF?FFJE@CGHIKGJ'FGIH1J>HJFI-BG:FG?IIGHK@2AEK8H9BK%+1JE6JDFDH=GDIJJKG69K0?-KKG=IHK+FFBJKK(K=KAFIKKCGKKKFKHHGGA@>9E.BJA4>JH-KAKKKKKKI7HG@?I,JJIB;HJJDG-GF@@?A=C4FEKFK6HDH@I:IJKIFIKIEH.JIKIJKKFH?HDKIKJJIJKJKFJIG9$;K9E@BIJHEFHF'JIJIE,KKJJ@I3AF+&KDAJK6JGIKKJKKKJKII(53KK3D8J+KKHC@;GGCF@G2AAIBHK2KK@JJHIGJBC=HG,HJJIIA4@55IDHF3GI@BIA@@)FIKKCKIHK??B,K>JIIAKBH,GHCJJE-JCKJHJ9FGKEKBKJAII?DJ@JFE4K%>J6G?K:FC%E(%=HA7I;C8CAB=FJ+KKJFDJKDK&G=DJ3FJIIJHJJKJ8EKHBIGIE9ADGGED>$DCDI9FI=>FEK>IIB1EHH>G:HH'>>9EIEJ0IB?3H.HC(BGIDI6FKKCK>HG9A>4F;K32IJ0DEFFK9<+4K6J>%AFJ@GJJ,HK8G=?DD&8IG1>?IHGHFIJIIDHEIKJG<,7<@8I:HB::;FJ+DAKDIK8JK=H=78*=DDAAFJ=GJK;JJK5KJE4?9(=K07EE,DI@HKIBDB6CG>JJH)CE=AH8G4J3KDKK93EDKKJ)>=F9BI,HDGABIH1-JH0<>A*GI>G3FJHJBCGCE=EDE/09,CFC6%>ECD,=AKJ'8A9A6A-?@-E3A<-@0;6DGAGD5;*)1163-HKDCHB>;98;2@58G*A?@I@A3>I9?GJK9?2B->CA?>DKKCBGH3:@@CBIJ.HAGK0>A@):#<>FBGD79&8D*JC?>A-4C>88F.JCFE/HJ<)C78CC?/6CH7D79DFD2@&@EG,6CIJ/BH*4HE5?>B @rCer/62/1507_55_CCS ATGGAGTGCGTGCCCTGTCCGGCAGCCGAGGAGACCCGCGCAGTGCTGCCAACGCCCGGTGGAGAAGCTGAGGTCAACATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCATCGGAATATGTACCACTGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTGATACTGCAGGGCAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAGACAGATGTATTTCTAGTCTGTTTTTCAGTGTCTCTCCATCTTCATTTGAAATGTGAAAGAAAAGTGGGTGCCTGAGATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGACTCAAATTGATCTCAGAGATGACCCCTCCACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAGACTGCTGAAAAGCTGGCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTTACACAGAGAGGTCTGAAGAATGTGTTTGATGAGGTATCCTAGCTGCCCTCGAGCCTCCGGAAACTCAACCCAAAAGGAAGTGCTGTATATTCTAAACTGTTTTCTCCTTCCCTTCTTTGCTGCTGCTTCCTGTCCCACTACTGTAGAAAGATCGTTTAAAAACAAAGGAATAAAACCATCCTGTTGAAAGCCTCTGCGTCTTTTTACTCACCACCTTAGAGCAACCTCTGTATTAGTTTTGATCAAGAATGCAATATCTTATAGAAATTTTTTGTGATCAGTAGTCAAGTTGGACTTGTTTTAACTTTCTGCTGCTTGAGTTGCCTGATGCTCAGAGCTTTTTGGTTTGGATTACCATTGCAAAAGGGAACTTGGTCTGGCATTAAGAGTTTCTCTTGGAGAAAATAACAAGAGTTTTAACACTTCTAGATCTTAGTTCTAGATGGAGAAAGTAACACAAACATCATTTTACTCTTATGATCAATTGTTAATTGTAATTGCATGACAAACCTTATGGAAAAGGGTGACTTCTAGTAGAGTGTAACGGGAAGGAGGATTCTTTTCTGGTTTTCCTTTGTGCAGTGAAACTTTGTGTTGCTGTTGCTTTGGCTGTCTGTGCTGTAGTGGAGTATTTGTCAGTCTGGGTGGGGAAGATATTGATGTATCTGCTACTGCTTTATGAGTTCATTTGTTACGTTATCTTTTAAGAATAGCATCCATTTAAACAGTTGACTTACAGTTTGTTAATGTTGAGATGTAAAGCTGCCACTTTATATTTTCCTGCTTCTGATTTATTGTGAGGGAAATATACATTGGGTTACCTTCAAATTTTGAAATTAAAAATATACAACTGTTTG + =:=6>AF%CFBC/B.@/@A<:;:48=,664ADCCAA6>@8C8>@=B21'7B3BE@?>A>E?=4D=FAE;=BABBBA0=?:*<9A?(@E=DDA5<6=>23;%9@@@C9;=CIIAAE3@CDCH:G8?=5<)?>BA+:>/41,0/.=9;4@+><<=&C=?1<;6>:0$=<-<:9<'=53C5=?>3;@4>B>;7;9<2/$0,@:?4;93595.>63;9<;==??;?>>9=??%:84??0=7:9>6993:<<85=914=>,7=8;/2>;4?4A<7>71=23<>3<941;7;>A<8@7:A/4075>=4?@CAA1?6;8#0<><8@*1<=):B<&;>6?>?60<>?(?>=:,?BC<><27<8;2=@=@C:C>?B?=5@=81=8:?1=>9=>,>36159'7&:)8>@=;A6762%78>6??:>??:@=&=C@?8A9>6/>=><9+4+;<;@5>B65:+;;'&28A:8<<5A<774;3/7759:=/<7<>5>$6;@;<%@?@<<5<4824@428:;<5C:2&&7;78=>8849389:7.9+=@?.=27@7@B@:?;':;:>>7A=:4==>-;=89;;2:;.>.><585:B5?>5><>+@-A97;?B94366=@/@AA?;=77ABB399>8@69;.<8@CCA>=5=B>;=>0C:?@;7;.=;6BCBB?F;BC+B?@<>B;2?DDF*1D@69<<27=B>/;5<3:/:6>$,7;+><8<=<=74*9=?>B/A>@>B>9;C59/;924:C>732;-0178164227'9:=?C@BC?=A=CAC=9:@56=?<>>499@B>):98;3:/77889AC<->/A8=9A?@?@>-@5>AB2<2:6>?=><@=/>+<1&;?8=?98<87>84A?@@>C7;A<8=;70#&-)@4=>91289&59-<<6;:38=@(B*<>;A8/=@;A?BA>3>AA??<47AA2:/@2B@?A@BC9B;;?:=593;8:;B;=;@AB@=:=*@1>9>=91@A<-14(/2)$96<;:<68:::<57@:;96'77;.585?=?:BA@7B<;*?6AC1B>-@?=<775>>@8BC?B=@<95+),2>?6::83$0;;>(<5;<:<@6CC><=?A2@B;::44?7=A/998A@C=2<>A3?=,ABAC<;6;7==7C:9?27=B@;@?'<>?1AA2==89-68>>3>>7=<3A=@><)6;;=<9A?A8<8>@;25&4<2;:7BCC6@8B>?@367@?;:$9?:798;<9*.8)95553&30#-+?+:=5A=?A7,@AA,BCA>CB?=;9(?<473A,A=A<<2: @rCer/63/1517_58_CCS ATGGGGCAGTGTGACCGGGATGGCGCATTTTCTTGCACCGAGTAATGCGGTGTCGCTGGCGGCTGAGGAGGGCGGAGAGTTGTGTGGTGAAGTAGTGGGAGGGATTCATGTAGGCATCGGGAAGAGCCTAAGCCCACACTATAAAATAGGAAGTTAATGCGGGATACAGCTACTCCCGGACCGGCGGCGTGAAAGTCGTGATATCATCGTTGAACTATTGGCTTTGAAGTTTAAATCCAATGGAGAAGACTCAAGAAACAGTCCAAAGAATTCTTCTAGAACCGTATAAATACTTACTTCAGTTACCAGGTAAACAAGTGAGAACCAAACTTTCACAGGCATTTAATCATTGGCTGAAAGTTCCAGAGGACAAGCTACAGATTATTATTGAAGTGACAGAAATGTTGCATAATGCCAGTTTACTCATCGATGATATTGAAGACAACTCAAAACTCCGACGTGGCTTTCCAGTGGCCCACAGCATCTATGGAATCCCGTCTGTCATCAATTCTGCAAATTACGTATATTTCCTTGGCTTGGAGAAAGTCTTAACCCTTGATCACCCAGATGCAGTGAAGCTTTTTACACGCCAGCTTTTGGAACTCCATCAGGGACAAGGCCTAGATATTTACTGGAGGGATAATTACACTTGTCCCACTGAAGAAGAATATAAAGCTATGGTGCTGCAGAAAACAGGTGGACTGTTTGGATTAGCAGTAGGTCTCATGCAGTTGTTCTCTGATTACAAGGAAGATTTAAAACCACTTCTTAATACACTTGGGCTCTTTTTCCAAATTAGGGATGATTATGCTAATCTGCACTCCAAAGAATATAGTGAAAACAAAAGTTTTTGTGAAGATCTAACAGAGGGAAAGTTCTCATTTCCTACTATTCATGCTATTTGGTCGAGGCCTGAAAGTACCCAGGTGCAGAATATTTTGCGCCAGAGAACAGAAAACATAGATATTAAAAAATACTGTGTACATTATCTTGAGGATGTAGGTTCTTTTGAATACACTCGTAATACTCTTAGAGAGCTTGAATCTAAAGCCTATAAACAGATTGACGCACGTGGTGGGAACCCTGAGCTAGTAGCCCTAATAAAGCACTTAAGTAAGATGTTCAAAGAAGAAAATGAATAATGTTAAGCCATTCTTGATTGGGCCTCATAGCTTATTTTAGTCAATTTTTTGTCTTTTAGCCTTAACCACCTTTAAAAAAATTTGTTATTCTCCAGAAACAGAATAGGTGAATAGGGGTGATGCAAGTGAATTCGTTTTCATTTAGAAGCCCCTCTGTACAGATAATCAAAATTCAAAGTTGAAAGAATCAAAAGAAGCCACAGTTATGTAGGTCTGATTTGAATGTCATAATTGCAGTGACAGGACATTACTACCAGCTCTACCCTACTATCATCAATGTTGTGTTTATTCCATCAATAAAAAAGAGTCGCTTCCAG + <6>=9*872:592<<>D@8FCB@BC=@AD=)?>+C<=D564<9B1:;:<9A<;8EBFC6=C3:<>>@2;7?@@CD;4792=<=?B@:<8AA>DA@AA=8???E?@:ED5;4E=747A<<67=A6;<<7:67A=74><<;2><>=7<@:AB8C:7?>6<:@>>;><::1:<@>@;>87@B<8<9;6;9431@>8==?@A*?A69;8$6;1/A@@=<<5<;7:;7><79,8>=(75;;>:9>2>=:;,;@>;779='<91'::9;.:8<85<:2+@A8>7>@91>5<3:)@C984<74:8AA@B7A10@=?A@>9068*77/9=@3<@A6A59<;1680357666$80,6B>A=98:9,65<4<,44?8>@>@<9@@=514=89635:<;>;>$;<6;;<8959:;=3:@<=?>?A>57;=;>8?:8=7*473.;79869>2=9?=<699/673<@;@=:<9'@9=9@:>=<<.2;>A6=7/;298B;4A.?AC<9>B;9<47?>3<<@5842?A:9?9989;;<+<9@598;::9;=?C=8>=1?6>760659;=9*==0>:@77,046-0*70;==:@;<;6;88;=(;<1;610:49?8=12;<9357B=9>?/2;:+=99@0>44A37-?9:<>A893*98<8;69=0?><=<<;?>C;ABA8B6;?<5<;1C51./654@BC>>A-<7<;@;:0:27>014+5.),4=<6/9'1:+:5756<7465:6<64:808==59)>>?8,9;AA85>C?>-778:;:6.A<969>7A>C>@96=A5;5<9AC6<;=.;68=9<452:75;96>9?AB;C9@5@=;7'7=;5-94;7;7<;=>7A<:>A<7>::B?;7;;34825/*33===A<;2;256:734-,;1=8;966=7921<=>23A9=65=;9=@:;4=9=8:;5;988579@7<@6:<3<94>8:;0;8<>;691*-24+51-,9.8:,=><5>67<85;31'5;1/-8'5987:-81:77:14@CC9>@2,,35:616+43;6=>52573=):>6@<16:)>?=8:5*7+86435956,)785.'.;2;1;:97:)8508==/2/=09-81.(:9665*00/577$0:147553.,03/159;25<::34-3.048545<96.:7892;19568:0/'1;;?;9/8:86;94)4261*336>;5837/80/040.4%61844454)8=;,:719798:%4474<5%9<;<12=;9787/11/)13(33-86303:336%9589986413%3543,0872:4.33443/>;1;76038:697;57867992=<25<196::9>6539::3'989;6;898:87: @rCer/64/1613_56_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCTGTAAGCTTAATGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCACCCGAAAACAGGGTTT + 5476$9+0+94>=><:830,4/3+/:&33;2>=86<-76=796190874;1<9:;6>?:?<>9773<8964:<>=3>=97=959<78<=??:==;*+38<1;<=>:9+=>3:>>>>=70;5>=?96;8?=89:88<==2;;9=;/=537156;:-857>?>;=?>57$7??7;>>5:3:=47>;)<:727;8:3:?>=71?=<>?8=97;7;;<;98?7;>:9><=>;:?;=?9:7;(>>99287,:>;9(=;<;>???8=9>=?>59;-7:><===:85188$/5=>;=3=2+<=?9::4?9:5:8:,:;7=787=1:>6<<6;<4;<58@<><;@@='?:A:C;C9>?@A><5>B>79>B:=B8:>A>;=;?3;?8:><;%<<;70<<<65+$3:47??@;10%8.33*2:675;;>=5<7AA>?.B:<=>?>??ABB2:<,A<=*C@;C==CA;@?C@@;<;B@4?C@@>67;@66>9C?BBC:CB@?5BAAA<1BA;>?3<:68//.8<=&;=>.:?.7=>?5=;??A43=BA6:=AA=@96;;=299/A5B;05)25=6;;=<>9:>;6:@C99>47<=:?B>2:87A:C<>;=<<7;:=>?+=B4>>=?A@1@?BBA>-BB6<=A0:BA@@<;.@9<>6?><@>?>79A;?>=A9@=5@?7>A5;B9@C?A?==?>=C9:0:>ABA=7B;8@>B-A??<=5?<=>>A@>6<==5@;9>?9:=>&:A;7@?@92B@>?@<(;@AA?6;=<=>;9;/??:1;,?A?=34&=>>@/<:=8)>=8<=8?@?:B?>:?@=>27=AAA@3=36=+9CA=9=7=>1@/A8=?B?B>>???@=:@:@<>=;==@7:<>AC;8<@,BBB?;>9=3?>B899=8;9*3=67?=5(=7/;;940?<6B?9>6AB>A?8A58?B<;6;23<>A?=:;?@@2>4@>7>6.8:A0:;<<:.;?5274>2?7>=A:@7;<<9<=86(<@:->=C:@>=/@5<:1;>8?=6;@;AA>@9@B7=5<=3'194:;759=9?.@@BB;A<=5=5<=6;B=73)?C9A8>7@=3;;.88;@C6?A?<>@>7:CB?A@C=B?@BB?>@><>;<6?A@A2919;:=>&8*6:7=<@=6;39<67>9=<=8=9599;;@<77B?4?3<:>A5?=8@?-=A@>*AA69%==-56B=@3:3==@:9A:>:=?A7>7=>>:=<0=<>@A=,;67?>8@@3898,9@924;<@2A@:;6:@>3:21:9-*7<46*9;+?>B??;;?=0>>8?8?28;:51:0984)346:162;71=6<78:/6,3486+8341&0.0.4.$,)/&86;8/79;9327( @rCer/65/1666_55_CCS ATGGGTCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGATCC + HJJJ4DJECJIHKEKJKKIGHJJJI>DGHHHGKGJII?IBBGIGECHIGCHGIICHHKKKC?DJJFGJJG6GJ?JKKDJGGF4KKHKKKK=JKKCKFKJHKKK;KHBBJJEJKFIJ@BHJEJHHC+FJ?GFIGIIK@JHI2FII0>GIHK@ICKFKEIJJJJKDIKJJHK5@KJH?GKGIID4FJHDKJKJAHIGJKGJJIJ9FJFIJKKC=EJ9JEKKDFKKI,HIH9:E8BK=FG/KD?EHF8DDHHJJHJB>FGI;JCID6EGEFCJDDECHICHDIJJ;EI>EFHHFJF@9G=HFC@IFDIGD0JGCH8DIJGFFJBDEEHI+HDEIIHJ@BGEGJDJGGHIJIEJCIJG7FB@@JI>GIID@CEEDGHIJGEFB*?FA9B9;CF=B5FBFE?E7><4B>BA;:CCB@DA2?C=C>*B>@A?7AC@=?BE?AEBFBGCEE?FEC?CE>?BFBBB4B>ABGFEBFDE>;9DEC>@4;D?CEE@CA0>ADABBBFBBF>;FFE?B?@G>@B=A7C89?AE*AEGEGEEAFCCE;F?>BB;-:9E=@CDBECGB;GDGCBG?FD;AEC;9EF@AFFEA8EF;D7FE<=CAFG>BAEB@BDBE7DDAF=GDFG>DBBGA49F;A=4><+95ACE8?=DBEFBBDD3>=0@C6FFEFF:CF;C=CA?DBFFB;;?GGEE>B?<5:1@D>;B;DDB@CC8D>@@@9=;BEF=:ADDD?E;G>GAGAGEC?C??ACCE9@7ABFEC:BDGFDGEDCBAC;>DCCF?CD:CE=FA@>AGFECE-7GCBBC=GD>F@A9@D9B=B3A3CD@C>6C;9EC6EC6GCFC@B@@EE@B=D>?FA>GABED6?E?:FAAB7DCF=@C?D?C@>:>CFEF;5???BDFC@@ABB@?FEEAFDA?>>@E@ACBE6FCD;=DGCAE@CDD4CB@GCGB;CGGECDBECCGFEBACA<?FF?BG=C?AB1=:7BBGBF@FEFFG=?A=9?;B>DC?DD@BC?ECBE?F@C8FDACEFDG;D@AFBEBE-EB>DEGFD:C= @rCer/66/2382_48_CCS GAAGACCGCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCGGAAAAGGCTGCAGATGAAGAGTGAGAGAGGAAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAAATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCAGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAAGAATGTTACTAACAACCTGAAATCTCTGGAGGCTGCGTCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAAGAAGAGAAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCCGGAGCTCCGTGGGTCTTTCTTTTCTCTTGTATGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTGGAAATGTCAAGCAGATTATGAATTACATGACCAAATATTTTGTATTGGAGAAGCTTTGCGCACCAGTTAAATCTCATTCCTTCCCTTTTTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTCTTCCTTGAGTTGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCATACTTTCTTAAGACAGAGGCCACTTGGTTCCTGGGAGAATAGGCAGCCCCACGCTTTGAAGACCACAGACCCCAATATCTAGTCGTGGATATACTTAAAACACTGAAGAGCATATAACCTTTTTGGGTCAACCGTTGGTCAAACTATAGGGACCATCACACGGGTAGGGATTTTCCATCCAGAGCCAATAAAAGGGCTGGTGGGGGCCGGGGGGTGGCTATTGTGGGAAGTCATAAACCACAGATAGATTAACCTAAGAAATCCTGGCCCTTCTCCACACTCCACCATGCAGAACAAACATCCTCTTAAGCAATCAACGTAGAATGCTTGGGTAATAGTCATAATTACCCACATATAGTAATTAATAGATGGTAATTAATAGATCCTTGATGTGATGTTCTTTTGTGTATCGCCTTCATTCTAAAGTTCTCTGGCCGGGCGCGGTGGCTTTCGCCTGTAATCCAACACTTTGGGAGGCCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCCAGCCAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTATGGTGACACCTGCCTGTAGTCTCATCTACTCGGGAGGCTGAGGCAGGAGGATCACTTGAACCCAGGAAGTGGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGTCAACAGAATGAGACTCCATCTCAAGAAAAAAAAATAAAATAAAAATAAAGTTGTTCTCTGAAGAGCAAATGTCTCATTCCAGTAATGACCCACTCAGCCGGAATATGGTGGAGTTTTAGTCCAATTCAGGTCAGCCATATACAAAAGACTACAAGTCATTCATAAGTTGAGCAAAAGCGTTTCTATCTATTAGCAGAAAGGGCCTCTCTGGCAGCAGAGGTTAAAAATTGGCCCAACTTCATTTCCATACTTCAGGGAATAGCAAATTGAAGATTTACTTATCTAGGACTTGAATTCCTTCTTTGGGACCAAGTTAATAAAAACACCAGAAACTCCTGATTAAAACTGGATAATGAAGGATTCTGTAGACAGGGCTGCACGTATCGGCTTTGTTTGACTTCTCTTTTCTCAGTTAACATCTCAGAGCTGGAACATTCCACATTCCCCAGCAGCGTGTGGGGGCCGAGTAAGTTACAATTCCGACTAAAATCACCCTGTGTCTGGCTTATCTGAATCCCTTTACCCCCACCCCACCACCCCACTCCTATTTATTTCAGCACCACACTACCCAGGAATACACTAGCAAATTGTGCAATGGAATCAAATCCACACTTTTCTTTAGATTCTTGCAACTGTATCATATGTAATAGTATCACTTTTTCTACATTTTGGTCGAATAAATTTTTACATAAAC 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+/,155+553560466/6-41/0-356165201+44/,5445114311,./,102+45633/10/)6403+300645/561/3,-&514,(1-0%1.252-54..0/3/-6-516224+546656446,1--3)).56451415011)*22*34211.6220+.44620.24)500/543./-44)31561.14,10/,,$(.4-64-1//..50316452/4,(302.50305/1.-46-42+4556,/(3500).0.4/021&1/*#.1(&0%**54053113(/43/145-//646+1433.2-5651.13+./)4530241+.664634+.,021,41/0053432001.++&)03*1.&,055,.2+*+*5515522*)///.''1*401501522)/.13,33/0/0.-'04+3/0032(,-21-41+131*065640'51122166260,55114/-0)10133/&3/31/041).5/041-01--//*%+&34*31+50305,42.16151/662444/.543.11-+56262.0#(/*13,+,.2-0'3244%54514.45516621*++-,4)2+46/54196:293388.15+653&32'1.212&23&*02-2$62699117,2.0(/34580*+64)57(833:4.*4-499,85+96-1+/42.+)032736'4.020210444-59/;9936/598,337871+53+0/51.3%3714)34:8254/42586647/4507956;743(.+&53101+455::3504:47327,23.78*0887::-)498,6.5232587.:74558871513226968;0728:27:65/1927:767,645804060526401002458633'/84-5:1334.+6+2026'./32441.1159:/4948,:03184353/38&35'4127/8345444720+,3.0'9620442)-51'6346*96.:1588.9:726/825/6454:223/&-0.-88;4/20769/2973-5&67'+(/42+47265-*00353876647924-3.25657*887/52514612(.1&$$%:-942364$-1-025-:3944,3,385)5(43466119026515:603.7-8976739+715:6421205.5233440851353&/10/1'3-.+0',&/6120151615601.23--.20'93265::685(2(5.:6/636.1%1-.36347-4313893696571*5./22.277/685-65/0-*-+*+'245-414-4,%,10+11(0-19601+2//.4727,:2,81023.+414523)7+)+,28479511+3)0/617576+5)6.3/%.')/5*6115,2/./3'68;875:4133155%-0370261-0-9906848280/785.41-'.223+*3&5486668/9478316254674677-63:328931/48/35238:05/,3&054/0,39793438:,431/.0515.6915887+1954556(4).+1264613-269;2.54440366817142.345/3:/68801)-+0(-/*015576*-/+54/43-465271''05072398/33-+156658*,%(%33,41&0/4130,2714514.46755275442653437058-/+3444541$/982,1/,14)-58185263.305224*883.785448871360-'.2-2/15/,443122--2%404/3/236072)+)/.%5866)/.:.422210*00-0.'+/32/.)*142(35.5,364,4/,2.3777337565%0//74444-/1-24-1332-,.&26.3522,344.341134455407688)%(4.25))'+3,4/06'1360/0/,4056/21552021,;1+-)3233'+$"$43752,5441*13-4,976-7871-6.2955-23,2,2-.24(1+0)#.634564643/5+/62%1-713670,7310246.--742040.25-13/839/61#%034;8-2/6-846;4388:63.6,222409/5-4586+1+27,5.4180618349622433--+-,./1/311123,/,92633&-3(),105,)'2,(+.26+2.0-/20+)0*/(808622.65320,05+')"'$#'&",*),$#1&(,(*'5/&&$3/12$)..%/*24202*5170005,05/3$4-240/16421.2)**,25./715-5799%+50,+3,332$356135,5000*12/*0*2/1,123203165/.83//2254855-,./9593/)6).-278594+5672(4431,/'0 @rCer/67/1175_55_CCS TTGGGACGTGGTGTCCGCCATCAGGGCTGGCGGGACGAGACCAAGCTGCTTGTGGTGGACAGGGAAACTGACGAGTTCTTCAGAAATGCAAAGTGACCCATCTCAGGAGCACCTGAATGGTCCCTGCCTGAGCCCTTCACCAATGGCGAGATACAGAAGGAGAACAGTCGTGAAGCCTTGGCAGAGGCAGCCTCAGAGAGCCCCAGGCCAACCCTGGTGAGATCCGCCTCCAGTGACACCAGCGAGGAGCTGAATTCCCAAGACAGCCCCCCAAAACAGGACTCCACAGCGCCCTCGTCTACCTCCTCCTCCGACCCCATCCTGGACTTCAACATCTCCCTGGCCATGGCCAAAGAGAGGGCCCACCAGAAGCGCAGCAGCAAACGGGCCCCGCAGATGGACTGGAGCAAGAAAAACGAACTCTTCAGCAACCTCTGAGCGCCCTGCTGCCAGCCACCGGTGACTGGCAGGGCCGAGCCAGCCTTCCACCCCACCTTTTTCCTTCTCCCCAGTTACTCCCTGAATCAACGTACAAATCAGCACCACATGCCCTTTCTTGACAAATGATTTTTCTAGAGACTATGTTCTTCCCTTACCTTAGGGAAGGTGAATGTGTTCCCGTCATCCTGCAATTAGAAAGGAGACTCTGCCTCCCTCCTCCTCACTGAGTGCCTCATCCTACCAGGTGTCCCTTTGCCACTCTGCTGGGATATCGCTGGGACCTGCACCATGCCAGGATCGTGGGACCAGGCGAGAGGCACCTTTCCTTCCTCCCCCGTGTGATAACTGGGTCCAGGGCTGATCATTGACTGCAGAACTGCCACTCTCAGTGGACAGGGCATCCGTTATCCTGAGAGCTGTGGCAGACACATCTTGCTTTCATTTGATTTTTGTTGTTAAGAGTGCAGTATTGCAGAGTCTAGAGGAATTTTTGTTTCCTTGATTAACATGATTTCCTGGTTGTTGCATCCAGGGCATGGCAGTGGCCTCAGCCTTAAACTTTTGTTCCTACTCCACCCTCAGAGAACTGGGCAGCACGGGGAGGGTTGGCTACCCCTGCCCATCCTGAGCCAGGTACCACCATTGTAAGGAAACACTTCAGAAATTCAGCTGGTTCCTC 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rCer/73/987_56_CCS AATACTCAGACTCTAAAGCCAGGTATCAACTGACACTGTAGCTCTTCTGATGGCAAGAACTCAATGCTGGTGCCACAAGCTTGGTCTAGGACTGGAATTTCAAGCATAATGAATACTGTACATTGTTTAATTTTAAACTATTTTGCAGCATAGTACCTTCAGAATTTAGTGTATCTTAATGTTGTATGTCTGGGATGCAAGTATTGCTAAATATGTTAGCCCTCCAGGTTAAAGATGATTCAGCTTTAAGATGTTACCCTTCAGAGGTACAGAAGAAACCCATTTCCAAAAAGTCCTTTCAGTGGTAGACTCGGGGGAGCTTGGTGGCCCTCTGAGATGCCAGGTTTCTTTTTATCTAGAAATGGCTGCAAGTGGAAGCTGATAGTATGTAGCACTTTGTAAATTCATATTGAGTAAATGAATGAAATGTGATTTCCTGAGAATCGAACTTGGTTTCCTAACCCTAATTGATGAGAGCTCGCTGCTTGATGTGTGTACAAACTCACCTGAATGGACTTTTTTGGACAGATCTTCATGACCTGTTCCACCCAGTTCATCGTCACCTCTTTTACACAAAAGGTCTGCAGGGTGTGGTCACTGTTTCTTTTGTGCCATTTTGGGGTGAGAAGGTGGATGTGATGAAGCCAATAATTCAGGACTTATTCCTTCTTGTGTTGTGTTTTTTTGCCCTTGCACCAGATATGAAATAGCTTCCAGGAGCTCCAGCTATAAGCTTGGAAGTGTCTGTGATCGTAATCACATGTGACAACACTCAGAATCTAAATTGGACTCTGTTGTTCTCACCACTCAATTTGTTTTTTAGCATTTAATGGGTACATTTTAGAGTCTTCCATTTGTGTGGAATTAGATCCTCCCTTCAAATGCTGTAATTAACATCACTTAAAAAAAACTTGAATAAAATATTGAAACT + 1+#4.8:2*($-/(79754&>6%@B<6?(2@D<CD=<%DCA(>F95?5#6>I8IF<>F*;:<.EGE>FEH4=2=?EA?&F:FG699CG2>JDC837G%3%@.FE?-B?<4(79FIE:KCKFH/HB.AJGIHJ0JAHE&6D@&<8<,B+>/@::D;GCE2K=FCCGDGIHHE(GDDIK@HF?>/@96FF3F>:;H;6>JG+5F*FC:F5:C%B:;2>K9H>@HJK9J48@:7A4BB;$I;%9>BB5H8)2EB<@IK:BJ3HKK174KJJK&1FH4KK8II1IG1@HD9,JCJJJI&>>GK;HAHA.CG/8BFH9CCE)F6CGBC/%&79?-?9*&@D3AC2;7BD9G=1%B%CBE9DHF?9':<>CJ@9@5;&9.F3.EF?8%C>B,EH9E6AG9C@%BIDD24D>A=2>/'5BBEFHDE=CE;)$99.8=7EG::=8;B5B,D:=C+@:>BA<<&E.F@D?=B:F(A?F@C@/8-D6B'-:F1B.E1-BH83;0B:%=EHII8HG=')DF):1B-,9E./9A6ACFF3:C@=,;66?.DEBF:F@?032<0F>?/@JIEA8?58+&@=IJ>C%I;5D:;7.F5;:9ADHHGC+CG@;B)/GBC8<;$.11>5-08-.CBE?;?-9:5FJF>G/IA2+&/>BA1#**CF?=E7D9HCD4;;$79:?DC'HGH-ADEG:>.2@D&/8581+I;:,;D;HCI+@A=C>CJH>G:(FGEF>C@I==H<%@=F@5@G@FIGD>JBIG@E@FAA78@3;@E@A5F=A=D87C@B@DE8G>>H@:B@:CA@CHGGECG?EHF;DFBG?DFIB>AH?;3ADFAD5DEFBC-?HCAFA;>F67?A@CB;4>D1:32=4IAC@D5C)BE@:EFBF@C7EHGB5=30HCGFHDJIGB3GHDA=FD6E>IAEAC<7;GG:A?>CHB6ACH>CE;FC@9GDG>BC?HB7GD?G8A?EAJC?FHH:A<:BEFABG:I@9E7FCGFEFHE:8F9CDAIC@B7:B@C@8F2HD:4<>?<@GC@.E:?BBEFB5EED1D7A>B@EF5BHFHADGB@CIEEJG;@@DFAEBG=F>CBDB=BIFECC9HFG>EDIA<@A>=G9H=5BCCDCCIIC08AFCGGGAFDFDIEA7@C>?F>>9>JD>E>HCCJJHHIHBD??,B@C@>G?C;ECF:C<:F@GDD79H9;;D<8CADHIEFI&CFEC>>850ACB9<FFG2A>1CF8C4D:B4?ECC>FAI6FB@G:E?8HHBG9CCG9HHD>BE>HI=?BDGIDIA6B@;??EBA@DEGH6D3ADC?DGAE@0E?7?>-(6BFGHEDEG46?78=57AA?@C?E@@DI:9B?;JIBFH>HIGJAI:DIIEIBDJJFBJJ>9D6?E=B@@ACEE@<0$6=C=AAIHGI?JI4FKE@BF4CF=;=IHKHE6>F@JJFA?HGE8EHIKEJJ>IIAIE9;FFFCAGE<17A6GC:709;9FFIF<>H.C);8GI8C4B;A@??>9;BE9@@>5D:51=4434<=@1B=HFJ;DIHGGJB@K?KDHHJJKIHFJDI@HFH>1FJAGIJHDK3I>JEG>AJIJHK;JJDJIAHH:EI>GBIJFFEK;D/F?D4ED4HBB:JIIJE2IHH@FAJDCI;JJKHKKEKCGFF?G?FJGJH?IDFEEE1GIAI@HKKJ%FIFA21D@>GKGKE7H-JGE8E==I:1EHJ%EGCD;JJIGIIJH:82GFHHGJFDB;JIBFJDAJDDEC5E@FJ2DACECIB?IBKCHHGCH:AFK(EGHGHHEK @rCer/77/1073_58_CCS TTTTGATGACAACAAAGGATGCTCCTTTATCAGGGGGCCTGACTCCAGCTGGTTCTGCCACCCTGTTGAAGCCTGAAAAGGCCCAGTACAGTATCCTCTCCAGACATTGCAATTGCATGAAGACAGCCCCGATTTACTGGCTGCTAAAAGGTGCAAATCATATCGGAAGTGAACATTATGAAGTCCTTTTAACTCTGAGGAAGGCATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTACGACATTACAACATTTCGTGCTTCAGTAGGTATGTATTTAATTTCCAAGTAATTCGGAAGAACACAGATAACGTGGTGATCTTCTCTGAGAAGGATCAGATGAACTTACGCAGGTTACATATATTTTCACAAGGCTCCTTCTCCTGAAGAAGCCGAGGAGAAGTGAGAGCTCTGAGGAACTCTATTGTTTGATGTCCTCCGCGCAGATCGAACTACTGCTGCCACGGCTTGAACTGAGAGTCCCATTTCTAGATCATCGATTTTCTTCCTTTACTTGTCTCTGCCACCAAAATGAGAACTCCAAAGAAGGATAGAAAAACATCTTCTGAGAGAACATTTGAGAGTCCAATCTGATACCCAAAGAGATTCTCTGCGACCAAAAGAACCTTCATGATGGAATAACTTCAGTAAGAATTCCTGTTTAAGATTTACAGGAATACTTGAACATCAGTTGATGATGCAATGATGGCAAATGCAGCCCAAAATTCCCTTCAATACTCCTAAAACAAAGAAGGATATTACTACCGTCAAATCTTGAACGCCATTACCCAGGCCGGCTACTGGCTGAGCCATACTGGATGCCCAAGTGGATCATGCCACTGACCCTTCTGCCCGCACACTGACCCACTACAAGTCAGCTGCCAAAGCTTAGGTGGTCTTTATCTGTAATGTGAAAGCAAATATTCTTGTTGTTGTATGGGACTATGGTAGATAGGGAACAATGAGTCAACTCAGGTTAGCTTGGTGTGAAAAAAAATAAAGTCCAAATC + ,*)',,,+,+"&$#('(%&"$.%0,)*$)*,&)//.%-00$,.,601-,%+*3'2/'-*443)',.'-.&$$'&063&'&(/1%%,2/2-/)3(-*22221/*0004-0/-)0()2-*+40/.,*/61501546//201)5411/+6601/,$26642/511351+6/-5/41411.1),3.4530253)6,33,05431602.4165410)/,545+33)61+2/.--*01%63644)1/+-$/2,0450.421+4*'2%3(*/46653+2+-+/3)(1431(604.*2/1/31$*1&12)0-0301-2.114652.-/)-,-.4603-2-%--6011/,34012+3'00+0/1/-0#((521/1*0+44*//'522%+)((0*,0+&/665/2))60+*)$(%&&)'*.1*$,$2-0-/)3/1-.-.0&.56.0'1301)2/%45432566502*3220231*-3$+0-%$),(6403./.-*.30)*552//1.(.)0.4/0/42*06/2/#%)222(-,.,)&'0,--,$02,10*$1*,-1+/0%%1&(&,(*%/10.'(%%0,$-0,(%*)''))..$')$))*/)0-&.%%-+)-,)./(*---+'+/+*&-+.1'*//#.-$+,,&0'&*0//,1+%0(,1-1*$$--00*.,01.''-'0))'&+&-,.-*2/',&'%&2111+/**)$%1-,1.'+./.-0$)'.-0)%&+')10+)-,'0&-1,1+02-,111210/0,(&*0*)0),,/(0.&--,121/%.10*/-/*02*),-./0-02,-./)0.#"'"./-+++%+,00*,#)+)/*/,*20+1,,.1,/.+#"..*11-0.0,&'&/&-02.+*/-/($$$12011+&-2/&011001,/%//&,++&0.',+%+*,,,)#+&/)-,),-,-*((+++$+)'#((')*&+.,),'(-**-+),(,&'')--+,))-&++)%%&',*,-,('()(,&+,-,(,%+,+(&)++*))$$)(#%+-#,.*), @rCer/80/224_105_CCS TTCACTCGCTCCCACGACTGAAAGCACAACACTTATGCGAGCTCACCCACTGAAAGGGCTGCAGGCATGGCTGTACCCAAGCTGATTTCTCATCTGGTCAATAAAGCTGTTTAGACCAG + )'&(&$#'%#()%$%('%&%%%%'$'#''((&#"%$""$&(&$"$'$$%'()))('*++-,*1---+(/#(/,''(+$1-,00*122--&,+,0(2,.00(++'&*'(*/.,-/+304/ @rCer/81/30_1998_CCS TGGGAGTGTCCCAGTGTGCTGGATGAAGCTGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCCAGCAGCAACCGGGCCGCCCCCCAGGATGAGCTGCGGGGCAGGGGCAGCAGCAGCAGCCAAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAGGTCCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGAGCGGTCCCAGGGTGGACTGGCAGCCGGAGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCATCCCTGCCCTACTCGCCGTCGGCTCCCCTCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCCTGAAGGATGAAATTGGAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAAGAAGCTGATCCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAAACCGCTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTTCATGGCGCCCGAGTCGCTCTCCGAGACTCGCAAGATCTTCTCTGGGAAGGCCTTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCCGGGCCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGGGC + F;JA?KGJGBKEJHIKJFDBFKJJGHKIK@>KIKKFJJI;GKIII@JH;I??BBDIBCEHJBGHIGAKIEHJJH@AKCE3IDIKI)FFGC?B?GFFJGGHAKK)JHKJG)IEEHGFI>>FFBD@DCKCKJKJKKH?JJ;FEBG7IJ7HBIJAJKDKKICKE@JI>@IHGKGKKHE,<;JHHK:GHEAJHKJKK@KBIKIBKCJKKKHF-DH;JEJGGKIDJ?EEHIKFFJJGE:KBFK5JHI<>KHK>KKKKKDDJ8HEJKKEEGF?H>JKGICKGKIKFJ@KJ(KJIIBHIHKFIKEFD>DKJAKKKAFBFJHH;KKKJGKJJDJKHKFKKKJKAJGKJGJIGIK=KKJKKIKFBKKI@KIE=KKKKIJIKKIKGHGAHEGEEDFAJJIKHFKADGIJKKKKKHJJJKKKBHKGJKK?KKID?JKKKJJGJ9EKJKK>K4KIJJJ@G:8@E@IEIJCGKJJKK@KII;JJDEHKII,JJKJKJKDK7CGKJCGKKFIFEJDJDK@KIJJDKKKK'KKKKKEKKGIIKIAKHKCKJKGK@KIDKK=KHJHFKH-EEDHFA2@IKKK?KHEIKJDIGHIKKICJKEKGHKKFGJCJHKKJ?KKK.KKKGKKKJ@JAJCKKIKGJG.58KKKK?KKKJ?KJJJJKKJHKKKF6JEIJJKIJKHKKJFKKKKKAKKKJI>KKIKCHHKHKKKKKKFKJ5FJFIKKEKKHKJIKIJKDDJCFJKK;KJCKK9KJGKEKKKKK:KKKJIKH>CHDKKKDK=KBKKKKKKK@KK@KGDKEF9FE?HKIKJ?KEKKIKIKKJ7KJKEKKJKKKJKKKKGKJKIKKJJJHJJKIKIKKKHJKJIJKEG??KKIK?KKJFKKB?JKJJJKJIKJKKKKKKKHKKKKKCIJGJKKKBKJKDKKJKIKHKKKKKAKKKKKKKJHKKK=KJKJKKJKKKIJK:KKKKKK?KEKFK@HHGKHKKFKHJKJKKKHIKJKKJKKKKKKKKCKKG?IJGH?IIKKJ6JJJDKJGKCJIBKFGKIKKKJJKKK?KKJEJKIJKJ8KKKKKKJKKBKHKKJKKKJKKICKKJK7KEIFIKGIHIG='KKKKKKK@KK8KKKKKAKKJKKKKI&GKKKIJHJKKKDJFKJJKKGJJIIKKIKKKKKKKKKKKIKK>KJKKKKJ?KKKKIGKKJKJKKKKKKKEGKKFKKGIKKKKKIKHKJKKKEKBKKK0KKKKKDKKKKKI8@7GD5<-B9?CF@BD8;@C7F@>@;G1='8<@C2@C:=:B@G3DB4??@@8B6?@<9:8;3&A8>>BA?CCD7B9CDGGG6BB1D0EFEEEA?0D??@FAE8DB6@@@C@F@ED?DGAD@CGGAC@>?C7@EF9AD8?B@ACG6@BD7=AE@A<@AE8:>=B9A@?@8FA<80>AA@B;;EBA=D>7@(AEE9DDDB6BFB=C9;=ADCC'>>F?9CFGB>AC@0CDD2A8DBFCDAADFGG?C-DEDFFDE>BF;?A@@25C>E>CB?=CDCAAFE6:EDAE@=F?EBB;E@,>;9??;0>C1-6<.?596@C@0?EB97>EBB7CB4D8D=>@>27<<=:>:>GAGD5CGCE?BBEA5:B<>=6D>@FEA8J>@A27E@8;9@6AC6:@,B8;EAF;@;CB>D=<0FB>:AB8C?E9>9G<3/>)..:)7@?>A,>C;@?D8>A@E<78A2:ED,EB>@D:C>3?:C:FB@;.8AF>B=FG:FA@6B=A@09;74A>@C-B=>$?@A:5>,;?;EGFBC<:BABC4?D@?;;DBC@?E?:A?CA4?E>?3B6F@FEGA6DCCADBD5GCDD@FECC@ED9E78CD58D@;>FDC6BGCCB?5>?EFF92>;<<1BC?28A@=A:?@B549@959=DD?F:C??ED?@4B5CA7D;@DAEAFB>=DBACAA-<9C>@@3:897@<6@=4;:?DDB=D5;F;DBA=C:?@-9@:;>FB/:<63:<;:>CA>=C9A@5?4@A?C=?-::9?3A@2<=A;>?=B?C7;3<*@><4=@>=5=@CC9AC:855-588;<:5<68,=5==77A<@?@?;;6=AB=AC>@?C@=?4;?3?;A7<2<>><6=.;A2??<=7@=0@>;5-783<;:??:'<<=2-:A?6A<;?>C>?7@<636;@>=<@=A@8401;@?;@4?:58<3@B:=>6>B=9><>B?;;AA:@=6>9?6A1=;=@9<:?':>;<)@@98C<>?>=7;9<-;4;?=07:9<80?:@5@>B=:<:>BA:B?@?8=2=?@C@@>@>=89>6<6?>7.==<>?.@=>9>@;><<'+>(=@=99:98:8?>6>=@>>=0@?;>:79?:8BC<79/<=9;>6=>9 @rCer/85/2436_57_CCS ATGGGGCTCTAGCGGGCCGCGTAGCGGACATGGCGGGCTCCCGGCTCCGCGGCGGCTCTTCCTCCAGGGCGTGGCGGCCGTCTTCATGTTCGCCTTCGCTTCCCTCTACTCGCAGATCCAGGCCTGTATGGCCTGAGGGCATCCTACCTGCAAGGAAGACGCTGCGGCGCAGGCAAGGGCCGCTGGCAGCAACTGTGGGAGACCCCACGCTGCTGTGGGAAGCGCCGAGACTGGGGCTGGACACGGCCCAGGCCTGGAGCTGCTGAGCCTGCTGGGCGCACTACTGGCCCTGGGGCCCTGCTGCTGAGCCCACTGCGTCACCCCGTCGTCTACCTGCTGCTGTGGGCTGCCTACCTTTCGGCCTGCCAGGGACTCCCTGCTGCTAGAGACTGGCTTCCTGGCCGTGCTGGTGGCCCCGCTGAGGCCAGCCTCCCACCGCAAGCAGGCCCCCAGGGCGGGCGGCAGGGCCCTGCCCATGAAGACCTCCCTTCTGGCTAGTGCGCTGGCTGCTGTTCCGCCTCATGTTCGCCTCAGGCGTGGTCAAGCTGACCAGTCGCTGCCCGCGTGGTGGGGCTCACTGCCCTCACCTACACTACGAGACCAGTGCCTGCCCACGCCCGCCGCCTGGTTCGCACACCACCTGCCTGTCTGGCTCCACAAGCTCAGCGTGGTGGCCACCTTCCTAATCGAGATCGCCGTGCCGCCCCTGTTCTTCGCCCCCATTCGACGCCTGCGTTTGGCTGCCTTCTACTCGCAGGTGCTGCTGCAGGTCCTGATTATCATCACTGGCAACTACAACTTCTTCAACCTGATGACGCTGGTGCTCACCACTGCGCTGCTAGACGACCAGCACCTGGCTGCTGAGCCTGGCCATGGCAGCCGCAAGAAGACGACCACCTCCTGGCCCAAGGCCCTGCTGGCCACACTGTCGCTGCTGCTGGAACTAGCCGTTTACGGGCTTCTAGCCTATGGCACTGTGCACTACTTTGGCTTGGAGGTTGACTGGCAGCAGCGCACCATCCACTCCAGAACCAGTGGACCCAGGTGCGGGGCTGGCTACGGAAGTTCAGTGCTGCAGTCAAACTGTCCCTTGTGAGCACTGCGACTGTGGCCTTGTTCTTGATCAGCCTGGTGCCGTACTCCTACGTGGAGCCCGGGACCACGGCGCCTCTGGACTGGGCCCACCGCTGTTTGGCGCCGTGGAGCACCTGCAGCTGGCCAACTCCTACGGCTCTTCCGCCGCATGACCGGGCTTGGTGGGCGGCCTGAGGTGGTGCTGGAGGGCAGCTACGATGGCCACACTGGATGGAGATCGAGTTCATGTACAAGCCTGGGAACCTGAGCCGCCTCCCCAGTTGTGGTGCCCACCAACCACGCCTGGATTGGCAAATGTGGTTTGCAGCCCTGGCCCGCACACGCACAGCCCGTGGTTCACAAGCCTGGTCTTGCGCCTGCTGCAGGGCAAGGAGCCAGTGATCCGCCTCATCCAGAGTCAAGTGGCCAGGTATCCCTTCCCAAGCAGCCGCCCACCTACGTCCGAGCCAGCGCTACAAGTACTGGTTCTCCCAGCCTGGAGAGCAAGGCCAGTGGTGGCGGCGCCAGTGGTGGAGGAGTTCTTCCCACCGTGTCCCTGGGAGACCGACGCTGGAGACACTGCTCAGGCAGTTTGGGCTGCAGGACAAGAGCCCACCCCGGGCCCGCAGTGCCAACAGCACTCTGGCCAGGCCCTCCACTGGACTCGCACTCAGCTGTCTCCTCTGGAGGCCCCGCCCTGCTCTGGGGCTCCTCGTGCCATAGGGGCTGTCAGAGTTGTGCAGGCCCTGCTAGCACCCTGGTCTCTCCGGTCCTCCCCCTGGCACCAGCCAGCGGGAGAAGCGCAGGCAGCCCCCATAAAGACTCTGGAGCTGCCTCCGAACAGGCCACCCAGCCCCCAACCCTGTACCAGTAGTTCTCGGACCGCCCGGCGAAAGAAGTAGCTGTTTCTCCCGGCCGCGCATCCTGAGAGGTTGGGTCCCTGGGACTGCTCTGGCCTCCGGCAGGACAGGACCCAGCACTGTGCCTTAGCTGACCTGCAGGCCGGGCACAGGTTGGGGCTGCCCCTGGGTTTGCAGGGTGCTGCATTGAGGGCTCCAGGCCCACCCCACGCCAGCCACGCCCCTCCCAGGACTCCACTGTTGCTCTGTGATTGGCCAGGAGGGAAACACGACCAGCTCAAGACCCCTGGGCTGTGGGGTCTGAGTCTGGAACCCCCACCCAGGCCCATGCCGGAGGGAAGAGGCTGACTCTCAGGGAAAGAGGGAAGCACCGTCATCTTCCACGTCATCTTCACACCAGCCATCCTGCCCTTTAGATCTGGGCACCAATAAAGGAGTCTTTTGT + E?BIJ/EE@>GICJI1@9DIG?@8EG%IIIEI3>HA+AHIJ1E=GDB'><6*IDH6HBJFJ4D:;F4?K/:=IAKIJKKJIJHI3IK&K3KHJJHH,J'EIHHK)9?HKCJHKCIFCK5E;KGJHDIDEKHB2&CFCG0JK3HI/KAJ@DH&JJKJHEJIKKKG:JFBEHH$IJHEJCGCHA@K4KGGKGK>I>CCIHCIK4GCG2?HHBF2EI+?@3@@J(FHDGK7KIJGFJHGJKH2IJJJHDJ9D&KK9KFGIJK5AKKEKKJK(>JFGIAKK8HIIFGE?8CFAGDJCC>#CHKBGJJIKJE8JI8FIJ>CJKHEK>?FKFJEKIFGKKJKJGFIHBDGBGHJJJJJ:JKKJKKGJJKE><=+JJJKFJGHEIEIGEK4HK3=GIJKH4B:GKEJG3C'EJFHACABJ@@FAEB6CKJKJJFGJGJFHDIKHK@HJHJH.JKHGIJJ?IFEE1II&JAJCKDJKKJ8KHKGKI8BDJGGH0GH?GB*GK'KJ'K?K.KK-JHDJK+I%B6DBGK>FJB8HJJKJFI0IEJKJEKBIKJGI@KK?1K=DF5>G>DJJKAKH@EJBJGGBDEHHI7E:DK@GBFA=KDIJGKK:I?:HEHIJJHC9FJC:DBHHBEAJIJ7HGFK>FKJDHC4KCE8KK4JDKEHIHJKJD6>K>B@A8IJAJIKHFKKIFJHIGIKFIB;BEEEJFE;GGEEFCAEG?D7HKEJ8KK:JJGJHDJ8IKGFCF/IAIG?BCIIH>DD*DFKKAJI)JI*HGK&HGI;JDHK8JHGDH$&K*IBBG+GIHI4B@IJDCJHKECGKHGDJHFEEJJJ%CBH@E+FC3ICFGKIICKJ92GCECF@?7CI0KIGCHJ?HKI.>I'7I8ICGJHFGFJIIJIK:DEB*J+HGKJC>J(AG4FCK?KE:F6EJCFJEBCH-JKKI9CGK/GFEHKFD>DK9CF;IHJ>39/=;J=9HK.G2C92DC=?3,H1EJ%?BHIB=HAHHF6BGBEHJCFF*HHCI$GJIKBEDGE?7>H:I=E5I::IAF56?F$?DCJKH6CE<.IGED*?IKGHIH2IDEJIBGGF?C:=3J@HII8II)E>GGFK2FJI:5J=KJ3@A@B%FJ&A?$>@F?CDJ?JAH=DJC>HCCE7D'IKGJF:FJF>GA;JIHHBJHCHIHKCB>&HGI-FAG.DIJGJGIHK:=8E>E:B9+=>EHFIED2HH(IHAGBAEDJH-BI2FA@AGC/G=CB(AIGGF)BB7HEG5JHHCGJFGD(;A@('DGHHJ9*?BCFAG44EJH6HDAJB@J=:DDBBH7DI@GJ?JAF48+5DE*FDKKKK6KCJE2IEKB9H@D:KKCHDCDAIJJB:JJ'BEEI4D9G>G>FE6AB?FDC;HG6>1HI7;H?5JGCC%03DK*JGHCB2F=;9E&AGIIKI)CFG*;F2IF>@G*GB@%=C6AB?>';CGEC@7C?D,H5HD4C&.C?'>B%JI'DAAD&C)>KJ+=:JHIAICH7+A99C?HHACGBDJHCKI7,C$EJJ8EBKJ/KK>BJIDBBKK29BJ8B:EHI5B*B/FEIKK;GA @rCer/87/1951_56_CCS ATGGGTACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCGCTCGAGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGTGTGCACTCCCCAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCAGCTGGCCAACTTCCAGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGTGCACCCTGCCAGCCACCCGGAGCTGCATCTGTTCTTGGAGCATGTGGATGGTTTTGACAGTGTGGATGACGAGTCCAAGCCTGAGAACCATGTCTTCAACCTGGAGAGCCCCTGCCTGAGGCGTGGGTGGAGGAGGACAACCCACCTATGCCTACTACCTGTACTACACCTTTGCAACATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGCTTCCACACGTTTGTGCTGAGGCCACACTGTGGGAGGCTGGACCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAACATTTCCCATGGGCTGCTTCTGCGCAAGGCCCCTGTCCTGCAGTACCTGTACTACCTGGCCCAGATTGGCATCGCCATGTCCCGCTCAGCAACAACAGCCTCTTCCTCAGCTACCACCGGAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCCCCTGCAGTTCCACTTCACCAAGGAGCGCTGATGGAGGAATACAGCATCGCCACCCAGGTGTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCGCAACAGCGTGCTCATGAGTGGCTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCTGAAGGAATGACATCCGCCGGACCAACGTGCCAGACATCCGCGTGGGCTACCGCTACGAGACCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCATTCCGGAGGAGGCGGTATCACCATGAGCCCAGGCCTCAGTGAGCCTGGTCCATGAAGTGCCACCACATCGCAGCACTTTTACCACGTTTTGTCCTCAGACCCCTCCCATGCTGTGTGGTCTCTGCATGTCTCCGTTCTTGTCTGTCTGTGTCTTGCATGTCTCCGACCATGTCACTGTCCTGAGCCGCCCAGTGAAAGCAAAGCCTGGAATCTGCTCGTTGTTGTTTGGGCTCAGGTAGCACCTGACGGCCCAGGTATTGAGGGTCCCCCCTGCTGGTGGCCCTGTCCTGGGGTCCTCAGAAGCCTGACTGTCCTACGGGCTTCTCCAGTGTCCATAGGGGCTTGGGATGGTTGTGGGGGCTGGCCCTCTAGCCTTTCAGGTCCTTCCTGGACAAATCTAAGCCTTGGCCAGGCTGGAGTTTAGGCCCTGTCTTGTTCATGTAACCGAGGGTAGGCGGGGACCTGTACACCTCTGCTGTGGGCACGGGGCTGCTGAGGTCTGTGGAACTCCAGCAGCTCCGCACTGGCTAGAGCTGGGCTGAGAGCTCAGTCACAGCCCTGGGCTTCCTGCCTAAGTGGGTAGACGCAGGTGCAGAGGTGCTGGACACATCTCCGCCAAGTCACTGCCCAGCAGCCTTCTCCGTCCTGTCCCAGCCCACGTGCTCCTTGGGTGTCAGCTTCCTGTGCCTCTGTGGGAGAGGCAGCTGCCGTGTGTTATGTCTGGGGCACGGTCACTGCAAGTCCTGGATCTGCCACTCAACCTGGAGTGGTGTTCCAGTGTGGCTCCCAGAGCTTTGACCAGATCCTGATCCAGCTGGCCCTGTGTTGTGTTCTGGACCGAGGCCTTTGCTGTGAACTGCAGTGTTCATACGACCCATCTTCCTAGTGCATGAGAAATAAGATTATTT + =GKK+JGKCCGKF@KJJHKGH?DIHEGDDHKJKKKKKIFK)KKFKKJBK&EKJ=JJJH(DGKJJKKKIKKKKKKKK%KBKKKKGJG8KHKKKJKKKJKKKK:KIFDKKKKKKK;KKKKKKKKK>KEKKK%FH,IKKK>KJKJKJJKI.KJ;K1KHIK&KCKIGIKDKGK'HK9KCK*IKIICAHKE;HK?EFK9KHKDKJK(FGGJKKKKJKAK0JKIKKKJGAE9@KKIA6K7JIK,KEKJJAKFKFKKJJDHKBKDHKDKKKIK8I?KBKKKDKKKKKJKKKJJFK'KKBKKKKKJKGKKK;EKKKKFKGI@>CE1AKKIJFKK&JK,KK$JKDK6KHK>KKKKEKKKJIK)KKKEKJDB'DJ,JCKKJJJKCKHDKIHJ@IKGKKKKII4DJJKJGFKDK6:JJIF@KKFKK6GJK?K9IFJIK>JJKKKIKHJK4I<=J>DJJ;DHK)GKK>EK>E2JHKFJ:K6IHIDKKJGH>K:KKKKKJKJKHHEIGIH?:EFK2EK=JIJKGIHK/K5FKH:KKHK8>JKAIHEK%KKK?K'EKHHAJJKJKKFKFKJ8CKKDKHKEHKKJKAGKJK=KJK@AKHHKKK9KFJI-IKADI6JGHKKK?DKKK>KK1IK,.+BKAGBKIIKHJK7HK>IGCBK6KKKIJBGDJIJ@J4JGKKKHK@JAK,IKKGJ%@KK&B;IIKKCKKKK4JK>HK5@BKJ?K?FHKH7IK9KKKGKK9;@JHI/KCJKKK9KKKIKGKKDKK%CFK2KJKK6JKKKKK%FJIHK7BE.KH,IKKK:HKKK,IJ)EK9DK7>KHJKKKJKBI0@JJKKCGK>8EK0FIK?AK8KHHKKK.=KEKI&IKKJKHKJKKJK:KHF2KK2HJK?HK*KKDJIJ:KK3K=C9FK9JKKKEKKKKG=K=K@K'K9IK+JJIB=*KJ?JJ+KH$FKKJJJ%IKJJKKBKHKKKIHCIJIKKKKBK6@%7@JK?=IJI9FKKKH@=?JAH+KI:CI-H7KBK9D'BFGIJKG:KKGK32HKEDIJKK2KJKG=KFJBKJKKK9K,)JAKDJ'GKJKJK9:FKK2IIIJKJKEJGH,J8JB;*EGHJK+AF@<@.KK3:EIDK4:8;I)HIK4FK;KKK1KGKKAKK>KK=KJKKKIJAI6K'FIK7KKKI=&FGEK$)*JI4HGJJHKJEK>0)K&HKKHCKK+ @rCer/88/2593_56_CCS ATGGGGGCCGGAACCACCATGTGCACCTCTATCCATGGTCATCCTTGATGGAGCGGAAGGCAGTTTTGACATCAAGCTTCCGGAAACAAAGGCTTGCCAGCTCATGGCCACGGCCACACTCAAGAGGAACTCTGGCACCTGCCTGTTTGTGGCCGTGAAACGGCTGATCCTTTGCTATGAGATCCAGAGAACGAAGCCATTCCACAGAAAGTTCAATGAGATTGTGGCTCCCGGCAGCGTGCAGTGCCTGGCGGTGCTCAGGGACAGGCTCTGTGTGGGCTACCCCTCGGGGTTCTGCCTGCTGAGCATCCAGGGGACGGGCAGCCTCTAAACCTGGTAAATCCCAATGACCCCTCGCTTGCGTTCCTCTCACAACAGTCTTTTGATGCCCTTTGTGCTGTGGAGCTCGAAAGCGAGGAGTACCTGCTTTGCTTCAGCCACATGGGACTGTACGTGGACCCGCAAGGCCGGAGGGCACGCGCGCAGGAGCTCAGTGGCCTGCGGCTCCTGTCGCCTGTAGTTGCAGCCCCACCACGTCACGGTGTACAGCGAGTATGGCGTGGACGTCTTTGATGTGCGCACCATGGAGTGGGTGCAGGACCATCGGCCTGCGCAGGATAAGGCCCCTGAACTCTGAGGCACCCTGAACCTCCTCAACTGTGAGCCTCCACGCTTGATCTACTTCAAGAGCAAGTTCTCGGGAGCGGTTCTCAACGTGCCGGACACCTCCGACAACAGCAAGAAGCAGATGCTGCGCACCAGGAGCAAAAGCGGTTCGTCTTCAAGGTCCCGGAGGAAGAGAGACTTGCAGCAGAGGCGAGAGTGCTTAGAGACCCAGAATGAGATCCAAAATGATATCCAACCCAACCAACTTCAACCACGTGGCTCACATGGGCCCAGGCGACGGCATGCAGGTGCTCCATGACCTGCCTCTGAGTGCTGTGCCCCCTCCCAGGAGGAAAGGCCGGCCCCGCTCCCACCAACCTGGCTCGCCAGCCTCCGTCCCGGAACAGCCCTACATCTCGTGGCCCTCATCAGGTGGATCGGAGCCTGGTGTGACCGTGCCTCTGAGAAGTATGTCCGATCCAGACCAGGACTTTGACAAAGAGCCTGATTCGGACTCCACCAAACACTCAACTCCATCGAACAGCTCCAACCCCAGCGGCCCACCGAGCCCAACTCCCCCACAGGAGCCAGCTCCCCCTCGAAGGCCTGGAGCAGCCCGGCCTGTGACACCTGAAGCCGCCAGCTCGCCGCAGGGCCCGGGAGCTGGGGATGGCCTCCAGCATCAGTGCCAAGACTGAGCGGGCCCTCCAGTGTTGTCAAGGAAATGTAGAATCACTTTGTAGATATGGAGATGAAGAAGACAAATCTTTATTATAATATTGATCCGTTTTATGCCCGCATTGTTCGTGGCAGTAGACCCCATCTGTTCGTCTGCACAGCTATGAGGCGACACTGTCCGTCTGCCATGAAGGACCCCCATACAGCCTCTCTCCCACCCCTGACAACCCGAGAAGCATGTGGGGCCCTGCCAACGCCACTTCCTCAGCAGAAACCCGTCATGACGCGGCTGCTTCGGAAGCAGACGTCTGGGGACACAGCCTCAGTACCAGTCTTTTCCCTAGTTCCTGAAACTTCCCTAGGACCTTAGGAGAATAGTAGGAGGTCATATAGCATTCCCAGTGTCACTTAGAATTTTGAGACAGAGGAAAGTGGAGGTTAGTTTGTGGCCTTTTTTTCACTTAGCCATCGCAGTCAGCTGCAGAAGTCCTGTGACCACCTAGTCATGGCCAGAGCCCGGGACCAGTGACACCCTGCGTCCCGGTGTGCGTTCAGTTCATTCTGGTCGCAGCCATGAAGTGTCACCAGTATCTCCTACTGTGAAGTCAGCTGTGCTCTCTGCTTTCCACTCGCTTCCACGGCTTCGCCTCCTGCATAAAACCAGCGAGTGTCGTGGTGCAGGCAGGCCCTGTGGCCTGCTGGGCTGAGAGGAGCCAGAGCCCCAGGCGCCATGAAGCAGCCACTGGAACACCCCCGCCGCCCCCCACCCACCAGTCCTGCCCCTGCATGGAGCCCCTGTGGTTAGTAGCCCGTATGATCACGTAGACCCACCCAACACACTCCTGCCACACTGGCCCCAGCCCACGGCGCGGCAATGCCCTGCCGGGGATTCACCTCACCCTTCTCGTACCAGATGTTGAGTGACCAGCTCTGTGGCCCTGTGTCGCCAGAGGCTGTGATTAACTGTGGCGGCAGACACAGCTGTCCACAGCTTGGGCCAGGCTTCCCCTGTCCTCCCACCGGTCGGCTGCTGGCAAGGCTGTTCAGGACGTCACTTCTCCAAGTCAGCACTGAGTGGCCAGCAACCGCCTAGCCCTTGCACCCCACTGCCTCCTGGGCCTTCTGCTGGATGGGCACCTGGAGGTTCTGGTTTTACTTTTTTAATGTAAGTCTGAGTCTTTGTAATTATTGAATCGTGAGAACATTTTTGAACATTTACCTGTCAATAAAGCAGAAGACGGCAGTTTTAAAGC + 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@rCer/89/1719_63_CCS ATGGGGTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + 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@rCer/90/25_1970_CCS ATGGGGCGGAGGGAGGACTCAGGCCCGGCTTGTAGCTGGCTCTGTACCCGGTCGGTCGGTGGCGCGTCTGTTGGGTCCGCGCGTCCGGGCAGCCGCCTTGCCCTCGCCATGGCGCCCTGGCTGCAGCTGCTGTCGTTGCTGGGGCTGCTCCCGGGCGCAGTGGCCGCCCCCGCCCAGCCCCAAGCCGCCAGCTTTCAGGCCTGGGGACCGCCGTCCCCGGAGCTGCTGGCGCCCCACCCGCTTCGCGCTGGACATGTTCAATCGCGGCCGGGCTGCGGGACGCGGGCCGTGCTGGGCCTTGTGCGCGGCCGCGGCCGCCGGGCGGCCAGGGTTCGCTGTACTCCCTGGAGGCGACCTGGAGAGCCACCCTGCAACGACCCACGGTGTGCCGGCTCCCGCGTCCAGAAAACCCTGCTCTGCAAGCTTCGAAGTTCTGGATGAACTTGGAAAACACGTGCTGCTGCGGAAGGACTGTGGCCCGGTGGACACCAAGGTTCCAGACAGCAGAAATGAGACTTTCAGCTCAGTCCTTTCCCTGTTGAATGAGGATCCCCTGCCCCAGGACTTGCCTGTGAAGATGGCTTCAATCTTCAAGAACTTTGTCATTACGTATAACCGGACATATGAGTCAAAGGAAGAAGCCCGGTGGCGCCTGTCCGTCTTTGTCAATAACATGGTGCGAGCACAGAAGATCCAGGCCTTGGACCGTGGCACAGCTCAGTATGGAGTCACCAAGTTCAGTGATCTCACAGAGGAGTAGTTCCGTACCATCTACCTGAATCCCCTCCTGAGAGAAGAGCCTGGCAACAAGATGAAGCAAGCCAAGTCTGTGGGTGACCTCGCCCCACCTGAATGGGACTGGAGGAGTAAGGGGGCTGTCACAAAAGTCAAGGACCAGGGCATGTGTGGCTCCTGCTGGGCCTTCTCAGTCACAGGCAACGTGGAGGGCCAGTGGTTTCTGAACCAGGGGACCCTACTTCTCCTCTCTGAACAGGAGCTCTTTGGACTGTGACAAGATGGACAAGGCCTGCATGGGCGGCTTGCCTCCAACGCCTACTCGGCCATAAAGAATTTGGGAGGGCTGGAGACAGAGGATGACTACAGCTACCGGGGCCACATGCAGGCCTGCAACTTCTCAGCAGAGAAGGCCAAGGTCTACATCAATGACTCCGTGGAGCTGAGCCAGAATGAGCAGAAGCTGGCGGCCTGGCTGGCCAAGAAAGGCCCAATCTCCGTGGCCATCAATGCCTTTGGCATGCAGTTTTACCGCCATGGGATCTCCCGCCCTCTCCGGCCCCTCTGCAGCCCTTGGCTCATCGACCATTGCGGTGTTGCTTGTGGGCTATGGCAACCGCTCTGACATTCCCTTCTGGGCCATCAAGAAACAGCTGGGGCACTGACTGGGGTGAGAAGGGTTACTACTACTTGCATCGCGGGTCTGGGGCCTGTGGTGTGAACACCATGGCCAGCTCGGCGGTGGTGGACTGAGGAGGGGCCCCCGCTCAGGACCTGGTGCTGATCAGAGCGGCCGCTGCTGCAGCCTGACGTTGTCCAGGCCCCTCCCGGGAGGTACAGCTGGCAGAGGACAGGCACTGGGTACCTCAGGGTGAGCAGAGGGCACTGGGCTGGGGCACAGCCCCTGCTTCCCTGCACCCCACTCCCACCCTGAAGTTCTGCACCTGCACCTTTGTTGAATTGTGGTAGCTTAGGAGGATCTTGGGTGAAGGGTGGTATCTTGGCAGTTGAAGCTGGGGCAAGAACTCTGGGCTCGGGTAATGAGCAGGAAGAAAATGTTCTGATCTTAAGCCCAGCTCTGTCCTGCCTCCGCTTTCCTCTATTTGATACTATACATTTTCTGGTTCCCTTGGATTTAGGGATCGTGTCCCTCTCCACGTCCAGGAAACTTGTAACCAACCTTTTCTAACAGCAATAAAGATGTGTCCTG 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@rCer/97/1094_55_CCS ATGGATTAACCCACTAGCTCAACCCATTATCTACACCACAATAATCATAGGCACACTTATCACAACACTAAGCTCGCATTGATTCCTCGCCTGAACAGGTCTAGAAATAAACATACTAGCCTTCATTCCAATCTTAATAAAAAAAACAAGTCTCCGCTCTACAGAAGCTGCTACCAAATACTTCCTGATACAATCTACCGCATCCATAATCCTCATAATAGCAATCATCTCCAACAACCTACTATCAGGATGCTGAACAACAACGAACTACATCAGCCAACCCCCATCCCTAATAATAACAACCGCCCTCGCCATAAAGCTAGGAATAGCCCCCTTCCACTTCTGAATCCCAGAAGTTACCCAAGGAACACCCCTAACCTCCGGCCTACTCCTCCTTACATGACAAAAACTAGCCCCCATCTCAATCATGTACCAAATTCACCCATCAATCAACACCCACATCCTCCTAACCCTCTCCACCCTGTCCGTTGCAGTAGGCAGTTGAGGAGGTCTAAACCAAACACAACTACGCAAAATCCTGGGGTACTCTTCAATCACACATATGGGTTGAATAATAATAACACTAGTATACAACCCAACAACTACAATTCTCTATTTAACTATATACATTATCCTAACAACTACCATATTCCTGACTCTTAACTTAAGCTCAAGCACCACAACCCTTATACTAGCCCGCACCTGAAACAAATCAACCCACCTAGCACCACTAATAGCACCCATTCTCATATCTCTAGGAGGCCTACCCCCCTAACCGGTTTCCTACCTAAATGAATTATCATCCAAGAACTCACAATGAACAACAACTTCCTCATCCCCTCTATTATAACCATCATAACCCTACTTAATCTATACTTTTATATACGCCTAATCTACACCACCTCCCTAACGCTATTCCCTACATCCAACAACACAAAAATAACATGACAACTCGAAATACAAAACCCACACCCTTATCCCCCCACTCATCATCATCTCTACTCTTCTACTACCAATCTCCCCCTACTCTTAACCTTTC + KKK3KKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKJKKKBKKKKKKKKKHKKKKKKBKKKKKKKKKKKKJKKKKKKKKFKKKKKHKKKKKKKKKKKKIKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKAKKKKKKKKKKKKKKDIKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK6KKKKKK6KKKKJKKFKKJKKKKKKKKKKKEKKKKKKKKKAKKHKK?KJKKKKKKKHKHKIKKKGKKKKKKKK-KKKJKKKKKK2KJKHKKKJKKKEKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KKKKKKKK,KKKKKKGKKKGKKKKKKK=KKKKKKKKKKK?KKK>KKKKIKKKKKJKKKKKKKKJKKKKFKKKCKKKKKKKJKKKKKKKKKKKKKKKKKKKHKKKKK4K.KKCKKKKKKKKKKKKKK-KKKIGKK&KKKKKKKKK6KKJKKKKKKKKKIKDKKKKKAKKKKK5KKKKKKKKKKKKKKK?KKKKJKKKKKKKKKDKKKKK=KKKKKKKKKKJKCJJKKKKJKKIKKKK?KKKKCKKKKKKIKKKKKKKKKKKKKKKKKKKKKJKKIKKJJDKKKKKKKKKKKKKKKKKKK3KKK9KKKKKK=KKHKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKJKDEKKKKKKKKKKKKKKK9KKJKKKKKKFKKKKKKKKKKKKKKKCKKKKJKKKKKKK7HKJKKKKKKKKKKKKKK(IKKKKK9KK0KKKKK*KKKKKKKKK'KHKKKKDFGIHKKKKKKKJKKDHKKKKKKKK3KK;KKKK+KKKIKKKKJKKKKKK @rCer/98/1843_61_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCCAGATCATGTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTAACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCACACCATTGGCAACGAGCGGTTCCGCTGCCTGAGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCTTGCCCTCCTAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCAC + 7/997003+073.0*03*4663843566+550779288:79=;95==887*:?:<7/418=.5;=7><7==//99348545)751<:9;6=>;<656:;264/8<==6<=>=:896764<;>67/84950.61766<2?996)7>2:;78;/>98=<720:;:>=09<0?8868:/89<*=:62;80)::8&+29=:/8?999<;9:;56623127337:-433793:800)0-782-43743656)734254;-881'5965948346;8346.151/1.%.86/2028*215667,76/3:,02'24:771/9/*592*/03799.,'21,)*+.47;:81/+.1-5093/.033*7831/.1.52545+14:65732685++556.552134)%64266.854789/)1771046,74;800854061,'*0000284363)*,*.3103+#5419;:;4(53/6944.526377986112731.0+/-4458558:457882'--1,955+,47;58.8.83-&/1673//*3.5246211)121*1./0544+44/11*,*(++30210%+(,.-,20/31)004/01&/1-/2'.1040.-0*'-.-04.4.340-3--/624-//(451/5/23//0533&02.05534501+356/0/*-/*'0,/,/%+2314,51...5)345+42-3(22,*+5-/-10-/512/55602./'+*1'+/).-14124525141+,11536/.-)0)1/--(+,5222)12+23+/546214515/+21(-105551/1315(20')35-03,1,46+4.54021$,'3.*.(2,14*/,&034,/.2..1.)3-)($$+*--)+#1,-*2-2++)'&2'0.1'1123.33162+0,2-',20*//20612/2416234)*0/%1,,1/40.444'/)/.,5.0,1-645.00*416110,/.46061252)3535+0/1)3,10)223-.31404''14'52062/+2642/51,$,-0/(5613/1*'3%/203/+()..0/04-0531401+%6,4414402.21'2354,0-/4//2542,56/311-')10.52410543+5643/4*-041.4.2).1315455.1652/23214*2/4120)*56/544+)4*40+2210405431/--0-6646355014/24+-642454*345644556462//.*31,01.*555.,.25.)2.,0&2-)465512012*31350-3(1444-.412*45,/133/0-0,4--**0*564/5-0+(661265,3454+4456)2,0.1201/1$4/03-//+')21)1/613435*/13-0%024403)2,0355645/,021..'0/1*005/3*)24560-.%34./,(+3345/63203-604312)211+54441-&13*/1034130&1'352,4-/,1,04,/1-,+0152-/3-23/5412-/%%*0$''/46-/3)$/0%24)5&.6/51/00.55004*+,,560+4/23)3522.02..1'50046/15041414-362.52*'--*446323-530&/1-'3+53146(*)/1.,#.24463(/,-.3+304,/.62.422420$(/45*5325.1-12$02012+.141312)2.,/2564*-20212%555422(,'$4,,053250,,01)4(312)204/-3600263+4420'+/1+5,4.26111-)-$/6/02534,+2210/'.44065143(34+0.22'5343.. @rCer/100/25_1556_CCS ATGGGGTGTTGCGTCACGGTGGGCGGAAGTCGCGGCCGCTGTTTTGAAATCGGGCCGCGGGGGTCTCTCAAGCTGGTTCCAACTCTGAGGCCCCACAGCCTCCCAATTCCGGGCGGACCCCTGACGGGCCTGAAGCTGCAGCCGCGCCATGTCCACACCTCCGTTGGCCGCGTCGGGGATGGCGCCCGGGCCCTTCGCCGGGCCCCAGGCCAGCAGGCCGCCCGGGAGGTCAACACGGCGTCGCTGTGCCGCATCGGGCAGGAGACGGTGCAGGACATCGTGTACCGCACCATGGAGATCTTCCAGCTCCTGAGGAACATGCAGCTGCCAAATGGTGTCACTTACCACACTGGAACATATCAAGACCGGTTAACAAAGCTACAGGATAATCTTCGCCAACTTTCAGTTCTCTTCAGGAAGCTGAGATTGGTATATGACAAATGCAATGAAAACTGTGGTGGGATGGATCCCATTCCAGTCGAGCAACTTATTCCATATGTGGAAGAAGATGGCTCAAAGAATGATGATCGGGCTGGCCCACCTCGTTTTGCTAGTGAAGAGAGGCGAGAAATTGCTGAAGTAAATAAAAAACTCAAACAGAAGAATCAACAGCTGAAGCAAATTATGGATCAATTACGAAATCTCATCTGGGATATAAATGCCATGTTGGCAATGAGGAACTAAGCTGATATTTAAATTTCCTGCTTTACACATGTTATACCGTTGTTTTTTCCCTCAAGTATTTTTTTCCCTGTGAAGAAGGTTATTTATCTGCTTTTATTTTAGTCACTAAAACTAAAGTTTGTATTTTTACATTGTGATTTTTACTTAAAATATTCATTAACTTTTTTTAATGCTATTGATCTTATGAAAGATTATTGTAATAAATTTGATGGGGTTTGTATTTTGGTTAATCTTCATGAATTGAATAATTTTTTTTAAAGCAAAATAAAGTTTTTTAAATAAGTTTTTAAATTTGATTAATGGATTTACTCATTCCAATAAACCTTTTAGAAGAAAACTAAATATTTAAATATTTCTGCAGATAAAAGTATCAAATACAGTCAGTCTGTATACAAATTAAAATTAAAGATATGTTACCATTTCAGCTCAAGTTTTTAAATTCAATTTATTGCCAAGCCAATTAAAATGTATATTTCTATGAATAGATGAAAATTTATCTTTAACATATTCTTCAAGTGTTTGGTCTTAAATGATCTGTCTCTAAAAGGAGAGAAACTAATGATCTAAGGACAACACAAATTGAAATCACAACTGTGTGCTTATCTGCTCTGCTTTAAGCTAAGAAGCAATCACCTAATTTTTTAGGTATACCCTAAAATAATCATAAGTGTGTTTTTGGAAATAGTACATTTGTAGGGATTTTAAATGAGATACTTCTATATGACAGGTGTTTTTTTTTGTTTTTTTTGTTTTTTTGGCCTGTAGTCAATCCTGTTTAGGTCTCCCTGTGGGAGCTGATCTCTCATATTACAAATAATATATTCTCAAATAAAGAGTTGAAGTCTTC + KK'K??F@3KKKKKKKKJKK6EIKKK:KK+JKIKJKEK4KK5KKKKKG$@JCJK9K2KE,KK>HKK4IKKGKHKKFHGGIGKKJKEKKKKKKKKCKKKKFKDIKD=KKKK>CHJKFDKKKKGKFKGKJKKKKKKJJJKK@K1FFJKI>KKKKKKEKABGKJKJKIIKK4CKH?KHGGKJJF<>DICKHJGKKKJKBKK7KKKKJGKKKKAKKKFK>KKKJKKKJFKKKKGJHBKGG8KKKKKGJGK=KKDK>KHKK,JKCKKKKAKJHKKKDAG(5@CCIHK=IK'KKKKK5FKJK;KKKK'KKKIIK(IGHKDJJKK:KIKDKKBKKKKKKKI-FHJICKKKKKKKKKI3KKFGD=HKK%JJKKKAFKKIJKKBJIFEF6JKHKKK?K+G8EF?%JJJIEIKK'IHKKKK6?EKKJKJK:KKKFJKCHDKKKF=EC2E&%KKKKK7KKK>JGJDIEKKJ4IHKEKHK>JHJKHCK7GKJKKAK&E=8KKKKKKKKGKK,KKKK?KKKKKIJ+FKD5IKJKGKK7KBK/I?KKKKKBIJAKKJKHKKK?KKKKHKKIKK0KKK0KJKKJJJHJKKHJJKK4KKK>KDEJC1IFJJBJCKKKJKKBIKJKJHKKKHKK2KKEKKJKJI7KKKKHJGJHHKGHHKKJJKKKK8KKJKKKK.D@7HJJKKIKFJKIGK9IKKJKIKJIDJ3GJKKEKKKJ8JGKJKFKJEJKK%KIKKKKAKKIJKB5HH?KKEIK5KKG4KKK8FFKKKAIKKJFFKGKHIHKKKKJKKK+IFGKKKIF;1KKKKKKKI5KKKKKKKKGKKKKIKKGGKEGKKKJKKK7KIEK2HKKHJ3KKKKCIKKKKKKHKKGJIKJKJKKKBJJDEC?DHIK6KKI:KKKKHIKG6KHIFDKJ @rCer/102/20_2386_CCS ATGGGGGTAGGAGGAGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCCACCGGTCTCTAGGTGTGCAGCTTTGGCTGGTGTCATCGCCGTCACTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCGCCGAAGCCATTTCCAGCGACTCGTCGCACCCTTTTCTATCTACTTCGTTCCCCGCCAACCGCAACCATTGACGCTATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGATCGAGGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCGGGGCCCTTATCTGGAAAGAAGTTTGGAAACCCTGGGGAGAAACTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCAAGTTTGAGAAGAATTTCTATCAAGAGCACCCTGATTTGGCTAGGCGGACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAAATTTTTATGAAGCTAATTTCCCTGCAAATGTCATGGATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGATGGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGAGTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCCACATCAATCATCAGCCATTCCTAGAGAGAGGCGATGGGCCCATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTATGGTGGTGCTCCCAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACTCCTGGAAGAACTGATTGACTTTTTAGAGTGTGGGAAAACCAATCTGAGAAGAACAACCTATCTTGTCCTTGATGAAGCAGACAGAATGCTTGATATGGGTTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTCTTGAAAGACTATATCCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTTTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAAACTGCTCGCAGTACCAAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGGTCGTTCCAGGGTAGAGGAGGCATGAAGGATGACCGTCGGGACAGATACTCTGCGGGCAAAAGGGGTGGATTTAATACCTTTAGAGACAGGGAAAATTATGACAGAGGTTACTCTAGCCTGCTAAAGAGAGATTTTGGGACAAAAACTCAGAATGGTGTTTACAGTGCTGCAAATTACACTAATGGGAGCTTTGGAAGTAATTTTGTGTCTGCTGGTATACAGACCAGTTTTAGGACTGGTAATCCAACAGGGACTTACCAGAATGGTTATGATAGCACTCAGCAATACGGAAGTAATGTTCCAAATATGCACAATGGTATGAACCAACAGGCATATGCATATCCTGCTACTGCAGCCGCACCTATGATTGGTTATCCAATGCCAACAGGATATTCTCAATAAGACTTTAGAAGTATATGTAAATGTCTGTTTTTCATAATTGCTCTTTATATTGTGTGTTATCTGACAAGATAGTTATTTAAGAAACATGGGAATTGCAGAAATGACTGCAGTGCAGCAGTAATTATGGTGCACTTTTTCGCTATTTAAGTTGGATATTTCTCTACATTCCTGAAACAATTTTTAGGTTTTTTTTGTACTAGAAAATGCAGGCAGTGTTTTCACAAAAGTAAATGTACAGTGATTTGAAATACAATAAATGAAGGCAATGCATGGCCTTCCAATAAAAAATATTTGAAGAC + FA/KKKGJIBFDBHDDJIHKFBAJFD=?HGGEE0DCII;F8KCKIKBHK:GHGGKGIIKKKKE9JK8KDF7IJAGJC>JGHKK@JJIH?KJIKJDGKGKC2IJIKIIBI4ADDKIH2KJAIG@IIAKIFKIFHJ?G@HHHH7AIJGFJIDCKI5KKIIJHHH5DFCCEK=FJFI3HCK5KHEIIHJDJK=IIBJCJH8DF?IKGHKIFKD/FAHJIF?JEK/KHJBKK=FGJKK:?,@?E:GG/@5FFFAHEACD?DB@FCB=I@K2II?GII8GGIKI6KBEFI@AH=D8EH:AIDKKGIFFIJFA8F)DGGIAFG?5EI@HDJFHH:8A@I>HGFD2JD;?ABI=@(>FGI@AE?AHBFJAKBF8E@8@:@IIHIH@4?DDB3>?7;AAIJ:GAA=?IJIE5JH=EFC4C?DFFI7HIGH:AGDIIHC1B5J>K:KKKJEIA@=H2@JHIH0F?HGHEJJK.IID6EF7IH>@H4>AGGDKKGDJAIGG=1JAHHIJHH:GI;G?;HJJICH.KGAG>D3FB;GKH@JDJ?ABHIJIKDHCCGHJHKEKHJFJGG?+FFEBKHEJ@IFGHG9KCBHIF?KKCIB8I8G=>=ED@EGIBHCEI+JKK+D??HA+CBJHEH9A;KI?G-DHGFCKD<==FCE@D@JI2@GKJKG9KGKKJJFGIBEAA?F%FEH?@;@BFBHJG*KIFFC>E@>DKHJHF=HCHEEJGFH>JF@DJEGKJJF5GKHKJB@KC@ABJHGJ?JGCDE;F5EIGCBHBKIG/IFHJJCIJEBDH9FHCG<5<-KJ7DJBGGGHG9J46HJFKFIG@K>F&?6I9K?DJKIK@'DHJEKHFKGKAJF:B@HDIJFGJJK4HIEAF@FG8F2E7$CF=FGH9B=8DBGJJDHEFABAFDKFDD4EBAJA<>8CE@FD:<>@HA;HJI2IHKEEJJ@JIBKJF;;,FFID7DHH?@KE&DF@6>->FAFHEF9F4I@GHIIDEBJ>9@EFJ4I;DIEE/FDGGIEDIAFJGHIEF@IJG,HA=BJ=K0HGDIHI1DJ1C:,FE6EHDJ/@0G?D.HG:=>>=HJ?JHK?GGIDK?I:C*FDEKHCD0IICB8C>E@G?AFBIIJDG>I@B,KKIE@2GHK8KBBEJ7JI8HC,DBA?ID@H@CBECCEB?EDHBBA,DDIAEJ>BF@JH9IGDDED3;A%@B@AEFCHA.A>DEH=KBCAH>CHJJGDE$?DDFF9ACD@CCFD2FGGFFCD7DA=>GG0G;C?=>*9CGIH4KIBG<F@/FKH@GKFJG=IG.IJH@:F;HG8FDGGIAGJ?K@G:JBI8$DIKDGHF9HJF?KIH> @rCer/103/0_970_CCS TTAACGGTGCTAAAATGAAAATTCTAACCCAAGATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACTCATTAATAGTCCCATTTTTTCTCTTGCCATTTGTAGCTTGCCCATTGTCTTATTGGCACATGGGTGGACATGGATCTGCTGGGCTCTGCTTAAACACACATTGCAGCTTCAACTTTTTCTCTCTAGTATTCTGTTTGAAACTATATCACCGAGTCAGACTTTGGTTCATTTCATTTCAGGGTATTGGCTGCCTGTGGGCTTCCCAGGTGCCTGAAGTGGGCAAAGGAAGTAACAGACAACGATGTTGTCAGGATGGTTTTGGACTAGAGGCCCAGTGATGGGAGAGGTCCCTGCAGAACCCACCAACCAGAACGTGTTTGCCTGAGGCTGTCACTGAGAGAAAGATTCTAGGCTGTGTTATGAAATATAGACATTCTCACATAAGCCCAGTTCGTCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACACTAGGCTGTTTGGTTCAGACTTTTGGAGCATGGACTGTCAGTTCTCTGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAATCAGGCTCTTTCTCAGGGGCTCTGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAATAGAAAAAGTGGAGTTAGTGAATTGGTTGTTCTTTTCCCCGCATTTGACGACTGTCATAGGTTTTTAGCATGTTCCTCCTTTTCTTCATTCTCCTTTTTTTTTCTTCTATTATTAAGAGAAACTTCAAAGTTAATGGGATGTCAGATCTCACAGGCTGAGAACTCGTTCACCTCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACGAACTCTCACCCATGGTGTGAAGAGTTTCACGAATCTTTCAAAATAAAAAGTAATG + S#),+&,,--+&,*&'+',++)---)-$+(&%$&&*-,&'($$((-,(+,+--,-),,-)*-,.(,+)'--.#(,,,'(+))'$,"$)+%)-,%)''+++,))*(+()+..-,(++#&'%'*(,*,%%#$&&()-)'(''$-.,'(&)*,,-)),'+-((-+'(('*$*,(((,)('(*+-'+'&))('',$#('''#+,(&&%))+&)(%%$)*+))(("#"""#$'$((&&'(((('-,(#"$&&(-,,-,).-*')**(#+(-,)+),--'&(+'&)(**+'))#&--,$$$%%*)('+$#$'+'*--/+)))&#--.*)#)+/0'%*',/0%/0'$3154+4312&21,01612*34--3&01565/--.1)5./0.*3262611-6523&(14)+53)-+-2,+-*-)'*'&,'+54--,/+/+$4/.21+)0//,#1-,.-1025*)/42'%/01251&31./+)*,/)'#)(&+**--%++.0.+--01)*.,*/.*,//.)-.342.)3301..04*5206*/15,05+111#,*+/14&33((0()-*(00,21(6)+0*.65250%0*3*.*255-%+-.*/00'+(),2*1152)24/'005)1024$/#,-'+'-/,/*54/*-42#)(%0212//01+-.+.24--20//0*3/405*1//0+*1''++0/2+/05/-(+'%),3/)1)/2.&/,--242614/,/+//.)*.,/)01/00%-)((,..30.*/*%(3*,(-*././#$+-66420/1011+2(*''/$0.),.214-.01$+#&+.-*+..#%)//(+*#+-%5..)'$&-(33%,4+41+00&.,)$$()1210465/)+01/261)&3(0$&/5).))($'4,.1-60031-'555556641065,324102420/)0,%/'-*-,.%,.1.,//*+*-5100*455610,/..%/,2(11#&&%(-/25-4+3 @rCer/105/2202_56_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGCGTGAAGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAATTGAAATAAAACAATAAACTTTT + ;<>5*88>@@B<>:=/1<++-785=?A6AD<05-3+6.>5C5=CBE7JKH@AEDHG&AHH0<:IIHKJJGHFFKFF.IGGFCFI?A9IH5GEIDFCFH7CCI>DJ>?7?=@*9?4D9A?@:AEA&=FGH?J4G=>6CD'::8AF?=5:E=<$@B>F@*9@IBAF=F?:@B=HHGD:?FIFG(E:H@G8CBCABH?D0G1@BDAD>F;=CJKI0FA@D>C@@BECEGK-EDD@H9A7:@5G1ED>GH@I?E>F9>CBKA:EJFA4:DJKKHIF>AF>DG@+4B>F>IF>HFJJ3IIJGICIIHA/G8FIC;B'A?AFH>@B7>+FFA3K????CB+@HHHEECD+AHI8HKJKKIJKAHB47F4EGGH??4A>@+GK?>FDHE;@@4AAB@F:@EJI,JBBJEIJ2H?BB@E;?86=>BF>2*98=)23'&?>>E;=3IBIFG.2G=IHEI;??>CEKBIF+GBA8;A;@DFGA?1E6F2ID,I1HJJ.<@F(?BBA%6JAGDF@A3@9:?EFHIBDDEGH6A9BA21@=C;E9JDJFC>C7FCBEAKDAFFIFJKKB?>4DAHB1:B?GGA??=>?DFDIAIEE7E@CAA$EIKKICAEBDH5FHHJHE?GHDIB?FF>>?7AC?$53?<D@C@>DAF4DGKD:9FFC89??@9ADE<>=<2,=@5?2E7GCBDIFG?BJIDJJ6@>A;8CFHDF.AEE8?76%25?GFFBA;G?A$GKKIGCH7IHIKHG@.8>&8CC6EE=F?EE8C:?E?BHEE>7/,;BICE.DH@:15-B2=?:=@>BB7>GIIC@><>=5;9A>:?=5C;F?F;<):6A???=?051B?=FHCDIFCHGGF=><5;GFB4ECCDHGH=%03:7A.89:C@>9;'@17+27:8=G;A9FE@2=@><9CBDEAA->D8DA&?;CD=CC@78A5?A749D@4>E@>C;CHI?=EIECD8EA*C==B*;>CCE@EE9C84D$7=DIF=42:<7>DEEJ=GHAF=@=CC1:F(A?:+=CEG:B:BJ8B9>'CD@F>ADHJC?8C?498E0;G5FC0B??3>G;:?B7==CBEF6DFCID=A>;5B=FJECA8J@@6:DE4:3C9D=@'9?CG@GHA/@43C=6BH>=?81;8@A=?844B?BC?G31BC=9?B;=D,CB;6?;=@@?=/=B587.B=B/AC;7-1GA=?;(<;:==C9>CB<>6?CECFA;?C@E<;2CD;3:C7CFEEB:B;;FI;?C;04<58?<@'GCFADDG65>>.A?B*CEA42:669<>?6;0;::8(>B?E8?<=%.==/697D;E=;;0345$6?26140??9>40>ECCE7971=<310-AAD4=2>78<*<;?GDA6=:>==35<61=.@+A;G59DGC6<=CEBB;D?6)@1921=3&44==B@3)<+3B9BIC5<><8C5=77,7=DC@@?BCB:E?>C:==HI>GHADA@?8HAD>18(?EA.:67<>DA+EDEC>??8;CCEHC4:?EGIIH>>9?=@85=-B>D16=7:;CFG<>E=GAEEIDC2BA>EIF??B6A=8CGHIEIJ@CD6GFGEEH:2;DC=%8'5$131;+55:-0847?9-535%39;=;;;:66;>7<=4==9;872329>8;;=97%:5)30$7>=0/0848:60<0@<%9;=5'9=9@72-/;65=8-3=<&7:6>;>:)136::8;:A?-<<:<8A7<298C>A74?A-7::6=74;7>@:@>;8;.323009<97B<-95+><;8>677=;A+?;;79<-?>BB:=<&>:(%:5;7<9.=3<>A':295;(6=:=<=??49)8,:)?>DADA2:9@+B:2>91A5A<@>?,DB@9;B(BFEB<8>&?F>FFA<8<7@A@7?=@:1AB?EEE;*BBAA;5BA::9??=/C?:9)=6AAA0=?7@8ADEF?CF8>,????A?:CEABC=::;*=>=BAB+>CA=??6?/7?7>=:3B@?73>76@>=?BD@C>7?2>B9>.(8;:7@4>8?4?E@=58@EA4BE>/=??7;+@BF@:;:A<7;?<8>?:9-8+:7E<3A?@9BB9&::*899>66BD?@>=C6/58/1B>$9E>;8$A<?=4B;'0-4.;=E>;71:?<:?@4EE<>7:3?9D9;;A?AC:9?@BE.B*8<9>AADGFE9DD6'B):A;@14:;=D9GCA94:4998<:=@$79>><>:56'=7D@CCE@@<;9@BC;;:7=8=@0:>%::7239:7=83;8+;?378-99)43>7+5:=67>676>A>C9=@C<-:9<)837:7==@9015'84<0>81;88+28/6;1@<89:?@7@0<2<7:(0(66',%1$&1/65=?3:>@9<:@A9385:;<147)>68>B*4,48>;/2.:9C@9:6<%9:7=;:D.?A0DFF6FD?;E9>-6?BD>5=FCA1DDAF@<4>C9@?>?=73:/8>AA@D+=;A@1@>57%65&9=@:?CDB<>;=>$45001;9E=@2978;=@->CA;@E;D7=0B5E:==EB(1CFBEGF?H.D?=6DE8A?:@6D>CAED5C7E@IHBJ>D8?.8;'.'/5<,4+08872/86-4:*4(02:877CHFE6?A/;55DF98:EFACCD?4C@E@DCG>?BE;HEHFG9C5CE=(7>EGA;CDEB@%::EDB?>@H@@D@=1GG0078/EHH?IEFH=8/F>CGF?+@+IA&CDHFEH0DBEDADA647A>=*HGIFEE>DB?E?C.;HA8,5AECDAAFD>D6*@C>GGG97&D=C768/145B/AB@F@5$::11><2/CEFFE;E;FHIC;E?GBC@AGGBI@EDH5ADFEC/>*6B=HA4?C>(=?>7/E):ACHCEAA,EGC8FFHAE:E%A77>;@19880:6:.?9HEFB:;7=+0?CA5AB?:#8547/0>EC9E@B=.@397:3@8+6:;C8739:9*?B'>>?>D*B;&9/6>>6/@7*6+5)4C7%93#4(<=;4,;8)7.//9))/<<:4$9'9;=8:/@;F>D8GB:7D@FBAFFE@8B>?3DD>H:B>=?:=@<)BGC8*A=8B4GE=?/7@:A&?/39-@F=CH82$>EICE?EDJE?4ED:9=>-AC9?A@=99?@E;C*@E?=?9;BGI:8H7EA@;AGA=D>7A%A9ACD?+GC(=5.@A$514AD<@AF$;3981==@CDE8JG?I4EA/8:?DD,IA6FF,HF6CFCF8HHB4EGBEF9HADCA8-E><>)?F?8?D?9@CF>C@DEED<4GHI)CCC>:D=I5HA'EGCGC>AGGB?G;D@8B<-< @rCer/112/2177_54_CCS ATGGGGAGACGCGGAGCTGGGAAAAGGGAGGCAGAGGAGGCGGAGGCAGAGGCAGAGGCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCGAGCCCGGCGCCGAGACCAAGCGACAGACCGGCGGGCTGGGCCTCGCAGAGCCGGCTCTTCCGACACCCCAGCTGGAAAGGATAAGCGACTCCTCGCTCGCATCCCGGGAGCCGCACTCCGGGACTGGCCCGGTAGTCAGGGGCTCAAGAGCACATCCCGAGGCAGGTTTTGCTCAGCCTCCGACGAGGCTGGCCTTTTGGAAGGCGCCTTCAACAGCCGGACCAGACAGGCCACCATGACGAGAATTCCACGTCCGCCCTGCGGCCAAGCCCAAGCGGCCAAGGCCTCCAAGAAGTCCACAGACCACCCAAGTATCAGATATGATCGTGGCTGCCATCCAGGCGGAGAAGAACCGCGCTGGCTCCTCGCGCCAGTCATCCAGAAGTATATCAAGAGCCACTACAAGGTGGTGAGAACGCTGACTCGCAGATCAAGTTGTCCATCAAGCGCCTGTCACCACCGTGTCCTCAAGCAGACAAAGGGGTGGGGGCGTCGGGATCCTTCCGGCTAGCCAAGAGTGACGAGCCAAGAAGTCAGTGGCCTTCAAGAAGACCAAGAAGGAATCAAGAAGGTAGCCACGCCAAAGAAGGCATCCAAGCCCAAGAAGGCTGCCTCCAAGCCCCAACCAAGAAACCCAAAGCCACCCAGTCAGAAGGCCAAGAAGAAGCTGGCTGCCACGCCAAGAAGCCAAAAACCCAAGACTGTCAAAGCCAAGCCGGTCAAGGATCCAAAACCAAGAAGGCCAACCAGTGAACCCAAAGCAAGTCCAGTGCCAAAAGGCCGGCAAGAAGAAGTGACAATGAAGTCTTTTCTTGCAGACACCCCCCTGTCTCCTATTTTCTGTAAATACTTTTCTCCTGTTTTGTCTTGATGCTCACCACACCTTTTGCATCCTTCTGTTCTGACTTTGTAAGAGACAGGATTGGATTCTTCAGAATTACAGAATAATTCATTTTCCTTAACCAGTTGTGCAAGGACAGCAACAACCAATCTCTATAATGATGAGAGTGTACTTATATTTTGTTTGCTATTAACCTACTTACGGGTTAGGGATTTGCGGGGGTGGGGTGGGCTTGTGTTTTTGTGGTTTGTTTGCCATGAAGGTAGATGGGGTGGGGAAAGACACGAGGCAGTATGTTCGGCTAGATGAGAAGGGAACCAGAATCGTGAGGTTAGTAGGAGTATCTTTAGGTGAGTGAGCTTTCTTTGAGTTGGGCACCCGTCGCGAGAGTTTCAGAACCTTTGGCCAGGAGGAGAGAGGTGGTAGGGAGCAGCCAGCCGGCAAAGGAAGGAGGTGAAAAAAACTGCCACCGGCTGACTTCCACCTCCCAGTGGTGACAGTGGGGCCCAAACCCAGTTTCCTTCATTCTGTAGTTTGCCCTTTCGGTCTCCCTATTGTCTTAGGGAAAAGGAGTGGGTCCAAGTGACAGCTGGATGGGAGAAGCCATAGCTTTCCCAGTCACTAGGATGTAGCCATTGGAGGATCTTTGTGCTCAGCAAAATTCTCTTGTTAACGGAGTGAAACTTCAGGGGAAGGGTGGGGAGTCAGCCAAGTGCCTCAGTGTGCCCTGTTGAAACTTGATTTTTCCATGCATCGATGGATTGTGTCCTAGGAAGACTTTCTTCTGGATTTTTTGTTCTCCTGTACAAGAGTGTCTTTGCTTGGTTTGGTGGGGCTGCGGCCACTTAAAACCTCCCGATCTCTTTTATTTGAGTCTTTACTTAATAGTTGTGCTGGGGAGGGGAGGGGAGTGGCGGGCAGTGGACAGTAAGACATACTGCAGTCGATTTGGGATTGCTAAGTAGTTTTACAGAGCTAGATCTGTGTGCAGTGTGTGTATGTGTATATATACATATCTAGGGTTAGTACTTAGTTTCACGCCGGGAGCTGGGAGAAAACCTGTACAGTTGTCCTTCTCTTATTTAATAAAAAGAAAATCGCGTACTTGCGCGTCCCTCCCCCCGCTTTTAAACAAGTGTTACTTGTGCCGGAAAATTTTGCTGTCTTTAAAACTTTAAAATAATTGGAAAGG + (0110(',/0-00/-/(..,&110*/**/(()./1.+)*%,,**1,+''*,&.+/),&++',.2.+*%*1*/.+)1,*,,*/&.0+&(#&'./1(-,-0,+.++.2/0(,10./)+'+%.-,-0&.+.+$/'//-/+1/*0+2,'(*##1,+.0*/(*%+*0*+$,1/0,+*%###()-)-*1,(++/,-1/-,&((%+**))+'(,1)).%.--0*10)-'-),(/.0.,'-%00-,,%'%,**(/&.-1)-)/+-./+,%00/01,-1,,+-101')0+%.(-00,1+/,0-1/0*/%*2+,)&200--2.0+/*//--)/.(1,($#('&.(,%1-*11++&,0-)0,01+1(*%/2/0,)()-%+++&2/0*/.-2/,2/,+/&,/)$&'#()-%('#$)$.(%0-&,,-,-0,1,1-+,&(&2.00**2,0+1-%/*+(,-+,,(,.(2,,/0102--+'',)+$*).(+/,(++.1/--/,//+,/0.+/)-0$*-+,-%-0/+//),0-/-0,,02/%*(+&.++%+/)011,&((%./.*/-$&+,(-.,01+/*)*(%*/(/01(/00,,',0.+11,-./(*()'1)%+/,1,2/-,,1,..1/).%),-1///)%&/0+(%,(/0'%*%+%)*+')/',(.#.1/&*-%1*&.%+#%%/1,11),*'20*+),*2-+++'2--2-*,,*00-).(.#)011+1*1+1,,/,$00$(0(*.*')(%&/)/&),&.'.*-)+1+12-&+0,-+,0-*)%*,$($-+%..*+/-/',.*211.0*0'/*-'/1'''+,&0&--20/$(-2-01-%.(/*&2/-&-*,&1--,-.0*00-/0*,./$$1/10(/.0+22,*0&1-.&1211.%,0+)-+-.2*+121++/...&0+$&,+%'&#"%&$*%,01,-/*./.)+&0-0+(/),+*-.*%&(0.$#/-/%/(,,+%.*-&#)*+*.'-+$#*-&+**02/0(1*,/'/,,**/0*0,1++.0/./-'..,,*()%%.&,(&/'(&-1+0)%+1+-',-/,.%-,0,/,,-(11+-11--'(&)()111++/),,1+,0.0)()*,++,%*,+'1.1.-..++-%0,.'%/.%1.+,/&/))"$*//'/+.20.+'02/10/'/'.,.1**//0$#0.&**(**('*-,'((''/.).01,/0--/',,+&-0-.0/1.*+1/1*),+-/10/+12/-,*,--+*)#(&-*-/*--'-.*./&.)*%(&))+.,+,1+-0,,-,*-*-,/,&',-)+.$+--)++1./.-$+,.&-)..,10+,.(/)'$).-10,,011)1,&1*1,,,'2+1,*0)-0,+)+--0.*,$)),)**+-,+0+,,1,2011/*,+*&0/,'&*%#$,-.-#%)&)'+*$+&-'-**/+/*0/,/,-%'-12-,1#.*+,...'02,*,)-/'*%0-%(%%#&-+&)$%$*.-.)..-&((&()&,,.-,&(+.(.0,-%*11*-,+%,*/,$/.$(-&.,1./.,11,//1-)(+$,+,**-((&$'(+%$',&,)*,$%$,.+')/./+,%000.&+/$+&+--&.''/%(/+-111(+'%)'+%-+%,%%))&*'%+-$*/*.-+).%200/'+111+*(00'-.'1-0++1)-)*.-/0/11,,,0+(-.&.)$%+.-//)2/.-//$),1--1,,0,-)'*0)1-(**&*)%,/)-2-10/)*/.///%.0)(,2++')0-.),*%,-)--.%),2.2.//&1+,*+*%,$+-.,.*-+*&11/(/'(*0*,.-..-01/)-02/0/,*-+/&%+$(+(+(,,-.$,/&202++-1-(-00-)*/00)*//(/./+0.0011-/)'%)(+-,),.-+/--110-0)++($+0'2//+0-./-$+*$00101240031.-.+.))%'%('&('(&++&%)*,/.%.,).%&..*-3'5--*,-,(&-,-/+)+$((##+$(+(+,+%%&))(#,*)*)'+,*())*.,-&&&#-$$+,$*('%((##&*)*&&'*+(,'**%+()++)+*$$,---+'(#*),#%(&,-),,&-),**(',,%")$#')$*%*(*),,)&-)$#'(&)--+-.-'',$+,-'-+(,, @rCer/115/1820_65_CCS ATGGAGGTGGGAGTTAGGGAGGCGACCACGAAAACAGTGAAGGTCGGAACCGACAGCCTCCGCCGAAAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGGAGCAGCAGCGGCGGCGGCGGCGGCAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGACGATGGCGCGACTGGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCTCTACATAGACGACACCCTGACGATGGTGATGGAATTTCCTGACAATGTGTTAAATCTCGATGGACATCAGAATAATGGTGCACAGCTAAAGCAGTTCATTCAGCGACATGGTATGCTTAAGCAACAGGATCTAAGTATTGCCATGGTGGTGACATCACGCGAAGTCCTGAGTGCACTTTCTCAGCTTGTCCCATGTGTTGGTTGTCGTCGCAGTGTGGAACGCCTCTTTTCCCAGCTTGTAGAGTCTGGAAATCCTGCTCTTGAACCCTAACAGTAGGGCCCAAGGGAGTCCTGTCTGTAACTAGAAGCTGCATGACTGATGCAAAGAAGCTTTATACATTATTTTATGTACATGGGTCCAAACTAAATGATATGATAGATGCTATTCCAAAAAGTAAGAAGAATAAGAGATGTCAATTGCACTCCTTAGATACGCACAAGCCAAAACCTTTGGGAGGTTGTTGGATGGATGTATGGGAACTAATGTCCCAGGAATGCAGGGATGAAGTAGTTTTAATTGACTCAAGTTGTCTTTTAGAAACGCTAGAAACATATCTACGAAAACACAGGTTTTGCACTGATTGCAAAAATAAAGTCCTCCGAGCATACAATATCCTTATTGGTGAACTCGACTGCAGCAAAGAAAAGGCTACTGTGCTGCACTTTATGAAGGCTTGCGGTGCTGTCCACATGAGCGACACATTCATGTTTGCTGTGAAACAGACTTCATTGCACATCTTTTGGGTCGTGCTGAGCCAGAGTTCGCAGGAGGGCGAAGAGAAAGGCATGCAAAGACAATAGATATAGCTCAAGAAGAAGTTCTGACCTGCTTGGGAATTCATCTTTATGAAAGACTGCATCGAATCTGGCAAAAACTACGGGCAGAAGAGCAGACGTGGCAGATGCTTTTCTATCTTGGTGTTGATGCTTTACGCAAGAGTTTTGAGATGACCGTGGAAAAAGTACAGGGTATTAGCAGATTGGAACAACTTTGTGAGGAATTTTCAGAAGAGGAACGAGTAAGAGAACTCAAGCAAGAAAAGAAACGCCAAAAACGGAAGAATAGACGAAAAAATAAGTGTGTGTGTGATATTCCTACTCCCTTACAAACAGCAGATGAAAAGGAAGTAAGCCAAGAGAAGGAAACAGACTTCATAGAAAATAGCAGCTGCAAAGCCTGTGGCAGTACTGAAGATGGTAATACTTGTGTAGAAGTAATTGTTACCAATGAAAATACATCATGTACCTGTCCTAGCAGTGGCAATCTTTTGGGGTCCCTAAAATAAAGAAAGGCTTATCTCCACACTGTAATGGTAGTGATTGTGGATATTCATCTAGCATGGAAGGGAGTGAAACAGGTTCTCGGGAGGGTTCAGATGTTGCCTGCACTGAAGGCATTTGTAATCATGATGAACACGGTGATGACTCCTGTGTTCATCACTGTGAAGACAAAGAGGATGATGGTGATAGTTGTGTTGAATGTTGGGCAAATTCCGAAGAGAACAACAT + HJK&JKJKKKAKKKJKKKHIKAKKKK0HKKKKKFKK?KKKJK@CKKDKCKIIKKKKKKKKKKKIKKKKJKKKKIKKHKKKKKK>JKKHKKKGKKKKKAKKKDKKKKK0KKKKGKCKKKKKKKKKKKJKKJKKKKJKKJKKJKKKGJKKKKKFJKEKJKKEJHJKKKCJKKK=JKKIKKIKKK8JKBKK>KKKK>JJHJKJKFIIKKJKKCKKAKKKKKK=KJKKKKDKKFKKIHKKKKKKKK>KHKKHDGKKKKKKKKKJFIJKKKKKHKKK0K@KK4KK4JKEKGKKKKFIBB5KKIEKGKK7KFKKKKIKKKK%KK;KIFKKJKKDIKJKIKKGKKKK=KJKKKKKKKKKKK?KJKKKI7GKKKGKKKKKKKK>KIKJKJKKKKKKK/KKKKK9KKKIKKKIKKKKKKKKKKK?KJKJKKKGKKEKDHKKGKKKHJHGJEKIKKHKJ@GKKKKKKKKKKKIKKKK>JKKK1K$:AKKJKIKIHKKKKKK5E0:IDJKFK8JJKKK2GHKHIKIJJCAJHIECKJFIKKIKJK6JKKJKKKK:KGG1EJK%HKKK8JKKFKKKJKHJJFKJKJK>G@KJIDIKBJK:JEABGIKB79J:BGKK?JGJKGFKKDKKHKCKK/=JHJKKDKJC2KHJKJBK?J:JJ=E>EC?D4JGFKAGKKGF5*IKFIIIAJ0JKIJKKGHFAKGIGKKK;GGKEIKJIHKJGJKFFIF4<87H8JKBKKKCKKGIJJ9='KIBAI>IGI?KHEKJJ=IHKKJIKHK=GCJKJGHJKKKKJ>FJKIKAKIK1KGAJC+JKKII'KKFKKKGKKKKJEKKKIIHBGFKKHJKKKKKKKKJ,IIHKKKJCKKKJKFKKJKIKKKHIKHKKFKIKFKDK&KKBJJIKKFIIHKJ5KHJJGKIKKHKDKKKEKKKKKJ7KG@HCKKKJKHJKHJKHKJKKJJKJJKKH?KIIH9KK@KH4HHIIJGJKKKKHKK:KKKKBKDHKG-CEJKJKJGKCEJGBBIJFKFKEGJDCKBKAKKDKJFIKJKJDKI6KB@H?JJHJKKIKKKIKGKIKJFJKKKEJKK@KKJHKE2G1FKBK @rCer/117/2308_58_CCS CCCCCACGGCCCTGGGCCCTTGAAGCCTGGAGAGTCACCGCCGAGGGATGAGGACGCGCCAGCCCGGGGGACGCGCGGCTGCTTCGCGGCCCCAAGCGCGCAGCGCCCAGCAGCCGCGCGGAGCCTGACACGCTGTCCTCTCACCTCGCGCACAGGGCTCTGCGAGTGACCTGGCCGGCGAGCTCCGTGCTGCATGGAACGGCTGCAGAAGGCCAAGATGGACAACAGGTGCTGGGCTACAAGGACCTGGCGCCATCCCCAAGGACAAGGCCATCCTGGACATCGAGCGGCCCGACCTCATGATCTATGAGCCCCACTTCACTTATTCCCTCCTGGAACAGTGGAGCTGCCCCCGCAGCCGGACGGACTGGATCCCGATGGGCGGACAGCCGGTCGCCTGGAATCATCTCTCAGGCTTCAGCCCCAGAACCACTGGAACTCCCCGGAACCAGCCTGCCCATTTCCACCACCCTGAGACTCCCGCCCAGATTCCAACATCTACAAGAAGCCACCATCTATAAGCAGAGAGAGTCCGTGGGAGGCAGCCCTCAGACCAAGCACCTCATCGAGGATCTCATCATCGAGTCATCCAGTTCCCTGCAGCCCAGCCCCCGGACCCCAACCAGCCAGCCAAAATGAAACTGACTACTGGCCGGCCCCCCGTCTCTGGCTGTCGGGAGACAGAATGGAGGAAAGCGGAAGGCGTCCTCGGAGGAGAGCAGAGGAAAGGAAGGAGGAGGAAGATGACGAACTCTGGAGAGGAAATGAAGGCTCTCAGGGAGCGTCAGAGAGAGGAACTCAGTAAGGTTACTCCAACTGGAAAGATGATCTTGAAAGAAGAGATGGAAAAGTCATTGCCAATCCGAAGGAAAACCCGCTCCCTGCCTGACCGGACACCCTCCATACCTCCTTGCACCAGGGAACGTCTAAATCTTCCTCTCTCCCCGCCTACGCAGGACCACCCCTGAGCCGGTACAGTCCACAGAGTTCAGCCCATCGGGAGTGAGACTGAAAGCCCAGGCCTGCAGATCTATCCCTACGAAAGCTAGTGGTGACCAACAAGGGCGAACCAAGCTGCCACCAGGGGTGGATCGGATGCGGCTTGAGAGGCATCTGTCTGCCGAGGACTTCTCAAGGGTATTTGCCATGTCCCCCGAAGAGTTTGGCAAGCTGGCTCTGTGGAAGCGGAATGAGCTCAAGAAGAAGGCCTCTCTGTTCTGATGGCCCCACCTGCTCCGGGACGGCCCCCTTGCCCCTGCTGCTTCAGGCTCTTCCCCGGCGGGTTGGGAGGGGCAGGAGTGGCGTGGAAGTAGGGTGGGCTCCTTTCCTCAGGTAGAGGGGGGGCCAAGACCTCTGCAATCCCGGCAGTGAGCTACGGACTTTCTTCCCCTCACAAGCCTGGGGCCCTCCTGCTCTCGTCCCTGACCCTCCCTGCACAGGGCAAAGCCAGTCGGGGTTCCGGCACACAGAGTTCATGTTGCACCATCTCCCCGCCCCTCACCCCAGAGGTGAGGAGGAATGAGGGGCATTGGTGGTTAGGCCTGTTGGCTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTGGAAGCGGCCAGGCAGAAAGAGCTCCAGGCTCTCGTGTCGCCCACCCATCCCTCCCACACTCACTCCTGACAGCTTTCCCGCACTGCAGCCTCCTGCCCTCTGATTCTAGTGGGAACAGGCCCCAGCTCAGCCTCCGGCAGGGAGGTCGCCTCCCAATTTCAGCTTGCCCTGACCTCTGCTCGCAACCCCCGAGCTTCAAGCCTCTTGCTCCAGCCCTGCGGCTTCCCCAGAAGCCTGGGCTGAGGGTGGAGATGCCGCCTACACATGACCCTGGCCCTCCACCTGCCTCCGGGCCACGAAATGGGAAATTCCAGCACCAAGCCAGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCTTGATGGGTCAAGAGGCCAGGCCTGGCACATTTGGAGTGTCCTGGCTACCAGCTCTCACCCACACCCACGCACCCCCCACACACTATGCTCTCTCAGAATGTATTTATTGGGGCCCCCCCAGCGCTTTCCTCACCTGCCCTGCCACTACCTTACACCCCCAGCTGACTTCTTTCCAGTCCACGTGTGTATATAATGATATCTATATTTGCCCAGGTCTGGGTATTGCTCGCCAGACCCTGAAATCCTCTCCACGTGTGGTGACCATGCTGGGGGAGGGGACTCGCTTGGATAAAAGTCGCATTGGGTTCCC + )*&)(&)&#','**)%++$**(+'*,*)*%,0*/()*0()20-.))&-%/-3')+.,211--20*01-/'.23/0$1-20513$&%)'*141,*,45530--+))$%$-000-,16410,'--0-2/./1*+.*24./41($#3)&-*&(%','/-*1.)(&'$(#(+.*)*+),%%%,)(#($.(,*')&&)',0,2/*/)*%+*&(/*((((,,&(%(&&,)#(%(&+$%(*+'#*-,*)*$''(+,*$&%#'%)+)%+),*'('*0020-+2*+0,)-*011+-,*%+/**.1&+&(),'',,%--+%&//$,*&$))'/(-'#+/))+/.+*+%%%&//,-.,()()$$#%&'%%#$$#"!"%$"!!"$##!"""&$$+/0.-+*-%+*,/+*-(-+)(+%*'--+*+&0)-.+,)$('*%*'/),')**,'*%#$---$*&&%&$(%.#&%)*#*)*&,,'+'&,-'(0*00#)&-)222/'230'4-601)-3--452/3++41.3&.-+$%'2+(.02203(*)(''2'2,(31.31.42,2401262/-53+62551051)3.0+31+*21-*/21022431'$*2'24'/0,.*42.022450+510321-2/0*)02152/)'0($'-/4)2-2.*,0202/4+#'%.//0$015)0*1*.11*4#&)23+3652**1,.-$51()3215-4.5/,/)*.0.311,-050/,.,)-(,*+)&%'.*#*.-/%/0*.$33,&.+//6/0004-,.%%2353-)'1-*+.*/-)542,.2./)/)*+2,*,/)/0-0/-.*3*&002*,#0'461-,+40/1.0546.2/.//013.*.//&&$(($$50/52.3'05.1//00$*)*0346+34)2/10/1*/-+0.+3('2-+)*4/41+*'))'&'&$+$**535200.'.55)+.0.14(045*51411.%1,0*,/)),-%$#-/+(#(%$)+1)21+20*/-,20,'%+.+4+-.($)'2..+%/)&$%%-262/2,1)-++&%%$,021360**-(,,#//-%'/,+40$))30/*'6/$2*-)4-1+.*(/0),+.3053*.0%%**,'-+0,.(('$#)/$%)).4101/)352.-*4/6.0+2(19-()$)-1/.5.1*9:42424-73*028:+-/'41*3202,2.,*6111/%5:54-**/0062.4,),*+)&4473.,+4..4',$3-51/72.$011:8425-44'+11&/5/-$:29;57405/1176/9/7'2+%4(77:.:3083+8&4--,124)024)+'(714.25-+,*/303'%3/+4,;4/%):0'-24.243793-42/-638/0.9,4745)7332(+1'52963144322:.-0/1'53,998&3344802:4369:.591/67:8456/22/47+-30/11-%/)-1.52.741443*374-.3,/0-'.(51643.464663/4/51345%3489.7/752**&7668,.0,284*3,.5(-6--&+,,.)/83--,$0-2,2-2400--43642-2)/12+2+26184&(64+9:7053+3)1)',4312/&)4&2,4/2-1+&,1438;641.8772889-6.-/3302352*()22400023+5:7/-2&54)&+%-(11-5054/-'894656.+25034)*/--*$3.$-,11/-.43335701.343))-))(114/309/.46756967.7706.640328.5*2-'12042125735889-10211(+1)0)0687+5229663.%23--..&.51.,1).*&,540/16/3550.51.**%1/0+2-%(36,55002-.11)/-%///.*--.35-.-0//1-)1/31.)25+)1+..'0*)''+/(,5/)(1%1/6./,021+,+/2,001556..-%'+%+'-2)03&.'4)-132)'/&5.#+)/1%303-*/0)51.0,4+/..3/0,-,#-*+-,/.2111-)*,0-/204552/.6-/3)/0*1''('(+..,'&&'+-*-114.13.'+-'-/*(-'$(+)'$$,/'%%%)+-.%)*#-0)$")&'',,&$',.&(($&#)'),(,'&&"%#%'$%&(&'&,,&'$'$(*+,/+),,)+%)##($$'**,*+/-,+**',*.&0.,+),(000./-,(,*'+#$',&%&)*)*))$$%*.%%&+2.,%*--*$&.+*,'$#).'''&%%$#)'%$%%"$$%%)&#$#$&$%''%)('%&(#$"*+& @rCer/118/1672_59_CCS ATGGGGGAGACAATGAGGAGCACAGCGCCAGGGGGCGGCCTCGCTCCCCTGGCCACCGCGGGGGTCGCGGCCTCCCATTACATAGCGTGTCTCTCGAGCCCTGGCCTGCTCTCGGCACTGCCACAACGGACCTAATATGGCCGCTGGTGCCGGGACCTGCCGGGCCCGCGGAGGGTCGGGACGAGGTCCGGGATCAGGAACTGCTCCCGGCATTCCTCGCGGGTGTATGGCGTGGGCTCCCTTCCCCCTCTCTGGGTCCCGCGAGGAGACTCTCGGGCTTTGAGGTAGCATGGCCCAGGGCTTGATAGAGGTGGAGCGAAAGTTCCTTCCAGGGCCTGGCACAGAGGAGCGGCTGCAGGAGTTGGGGGGCACCCTGGAGCACCGGGTCACCTTCCGAGACACCTACTATGACACCCCTGAGCTGAGCCTTATGCAGGCTGACCACTGGCTGCGACGACGAGAGGATAGTGGATGGGAGCTCAAATGTCCTGGAGATGTGGCTGCTGTCCTGGGCCCATTGGGGCTGCAGGAAGTAGCTAGTTTTGTGACTAAGCGGAGTGCCTGGAAACTGGTACTCTTGGGAACTGATGAAGAGGAGCCACAGCTCAGGGTGGACTTGGATACAGCCGACTTTGGCTATGCTGTGGGTGAGGTAGAGGCCCTGGTGCATGAGGAGGCTGAAGTACCAGCTGCCCTAGAGAAGATCCACAGGCTCAGCAGCATGCTTGGTGTGCCTGCACAGGAGACAGCACCAGCCAAGCTGATCGTGTACCTACAGCGTTTCCGGCCTCAAGACTATCAGCGCCTGCTAGAAGTGAACAGCTCCAAGCAGAGGCCACAGGCGACTGAAGATCCTGATAACTGCCTGGGCTAGGGGTGTCACTTCCTAGAATGGGAAGGGAACTCTGGGTCTAATGGAATCCACTCCTGGCCCACTGTGCCTCTCCCCTCAGCGTCCCTTCTGACAGTGACTCCTCTCTCTCTAGTTCTGCCTGTTTCTTCCCCCTACTCTAAGCTACTCTTCCTTGAGCCCTCCCTGGCTGCTGCTTCTTCCCTCATCCGTCAGATGCAATCTGTGGGCCGCCCCTCTCCCCTGGCCGCTAAGCAGCCTCCATTGATTTCCGCTCGTGTTTATAGGATTTCCACTTAGCCGTGATCAGTAGTTAAGCACAGGAAAATCCCTTGCCACCCCCCTCCCTTGGTCGATGCCATTGATTCTGCCAGCAGCTCCTAAACCGCCTTACAGCTGAGTTAGACGATGAGAGGAGGCAGCAGGGATTTCCCTGCCTTGGGGTGTGGGAAATAGAAGCAAGTTGAGGAAATGGTTGGGAATCCCAGTTAGAACTCTAGAAATTCTAATCTGATTTTGCCACTGTGCCCAGCTCTGGCCCAGAGGGTAGAGTGCCGCCTGTAGAAGTTTGGGGCAAATTTGTTCCCTGACCTGAAGCGGGTTAGAAAGAACCAGCAGCCGCCCCATCCCCGCCCCTGTGTTGAGACAGGTTCTCAAGGTTCAGGGGAAGATGCATACCTCTTATGTAAGAATGCTTTTCCCTTGCTGTTATTCATACACATTTTCCACTTCAAATATACCCAAATATGGCTTTCCTCCCCTC + KKKKKKCKKKKKHJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKEKKKKKKKJKKKKIKKKKKKKKKKKKKKKKIKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKEKKJKKKKKKEKKKKKKKKKKKKKKKKKKKKIKKIKKKKFKKKKKKKJKKKKKKKIKKKKKKKKKKKKKKKEKKKKKKKJKKKJKKKJKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKIKKKKKKKKKIKKKKKKKKKKKKJKKKKKKJKKKKKKKKKKDKKKKKKJKKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKGJKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKJKKIKKKJKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK=KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKK-KKKKKKKKKKKKKKKKKKKKKKJKKKKKIKKKKKKKKKFKKKJKK>KHKKKKKKHKKKKKKKKKJKKKKKKIKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKCKKKCKKKKKJKKKKK>KKKKKKKKKKKKIKKKKKKKKKKKDKKKKKKGJKKKKKKIKKJKKKKKKKKKJJKJKKKKKKKKKKKKKKKKKKKKKHKGKKKGKKKKKGKKDKKKKJKKKKKKIKKKKKKKKKKKIKKJKKKKKIKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKFKKKKKKKKKKKKJKKKJKKKKKKKKKKKKKKKKKKKKKKJKKKFKKKKKKJKKIKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKIKKKKKHKJKKKKKKKKKKKK?KKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKJKKJKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKK=KKKKKKKKKEKKKKKKKKKKKKKKK4KK @rCer/119/25_1774_CCS ATGGGCTGTCCGCGCCTAGGAGCGGTGGGCTCTGTGAGCAGCTAGGCAGGAGTTGAAAATTTACAGAGTCCTGAGGCTTTCAGACTGAAAAAGGCTTTCTTCTGTCACTGACAATCGCCACCATGATTCATAGTCTTTTCTTGATCAACTCCTCTGGAGACATTTTCCTGGAGAAACACTGGAAAAGTGTGGTCAGCCGTTCTGTTTGTGATTACTTTTTTGAGGCGCAAGAGAGAGCTACTGAGGCAGAAAATGTGCCTCCAGTTATCCCTACCCCTCACCACTATCTCTTAAGTGTTTACCGCCACAAGATCTTTTTTGTGGCTGTGATCCAGACGGAGGTCCCCCCTCTGTTTGTCATTGAGTTTCTTCACCGAGTGGTGGACACATTTCAGGATTATTTTGGAGTCTGTTCAGAGCCAGTGATCAAAGACAATGTGGTTGTGGTTTATGAGGTATTGGAAGAGATGCTTGACAATGGTTTTCCATTGGCTACCGAGTCGAACATTCTTAAAGAACTCATAAAGCCTCCCACTATCCTTCGAACGGTTGTCAACACCATCACAGGAAGCACCAATGTGGGTGACCAACTTCCCACTGGGCAGCTGTCAGTGGTGCCTTGGCGACGGACTGGGGTGAAATACACCAACAATGAGGCCTATTTTGATGTGATTGAAGAGATTGATGCAATTATTGATAAATCAGGCTCCACAATTACTGCCGAGATTCAGGGGGTGATTGATGCCTGTGTCAAGCTGACTGGCATGCCGGATCTTACACTTTCCTTCATGAACCCTAGGTTGTTGGATGATGTCAGCTTCCATCCTTGTGTTCGTTTCAAGCGCTGGGAATCTGAGCGCATCCTCTCCTTCATCCCTCCTGATGGAAACTTCCGCCTGCTGTCTTACCATGTCAGTGCACAGAATCTGGTTGCAATCCCAGTGTATGTCAAACATAACATCAGTTTCCGGGACAGTAGTTCCCTTGGACGCTTTGAAATAACGGTGGGACCCAAGCAGACGATGGGGAAGACCATCGAGGGAGTGACTGTCACCAGCCAGATGCCCAAGGGGGTCCTGAACATGAGCCTTACTCCATCACAGGGGACACACACATTCGACCCAGTCACAAAGATGCTGTCTTGGGATGTAGGAAAAATAAATCCACAAAAGCCACCAAATTTGAAGGGGACCATGAGTCTTCAGGCTGGAGCTTCCAAACCAGATGAAAATCCCACAATTAACCTGCAGTTTAAGATCCAGCAGTTGGCCATTTCTGGACTCAAGGTGAATCGTCTGGATATGTATGGAGAAAAGTACAAACCCTTTAAGGGCATAAAATACATGACCAAAGCTGGAAAGTTCCAAGTTCGAACCTGAAGGGAGCATTTGCAGAGGGAATAGTATTGCACACTTTTTCATTTCTTACTTGTCTAAAAGTAAAAAAAAAAATCAGCCTGTCTCCTAGGTCAGTCCCCTCCTGGACCCACCCGCTCCCTTTTTTCCTTAGCCTTCAGTGCCATGGAACTAATCAAGGGAGGAAAAGGTCACCAGGGAGAACTGGATGGAACTGAAACACAGCAACACCAGTTCTCAAGGACGAGGTGTGTGATGGGGTAGGAAGCTTGGTGCTTATGTAACCATTTTAAACATGGTTTCTATAGAAAAGACCAGCATTGTTTAGCTTGCTTGGCTTTAATTATCTAAAGCCAATGAAATACTTCTTTGTTGATTTTTAAGGTAGAAAGAT + IJ&HIIIFGJKJJGHKFKFKJKKJKH?KKKKJJIKKKKKHKKKKKKKKIKKKKKK8KJK@KKKJIJJIKKKKKJHJKHKKKJKKKKK8KKKKKKKBKKC?GKKKKKKKJKKJJKKKKKKJJKHJKB:KIKKKKJI=KKKKKKKKKK>KKKKKKKKKKJKKKK7KKKFKJIEKI@KKKKKKJK4KKKKKIIJKKKKKKKKGKJHJ/KKKIKKDKKK8KKKKKH?JHKKJJKKKKKKKKK@KKJKK@KKKHBKKKKJJJAKJKKIKKKK=9KKHJBKKKGJKKKKKGBFKKKHKBKFJKBKKKJKKAKKKFKKKKK6KKKKKIKJKKIKGKJKKKJKKKKKIEKA:KKKKKJKKIJKKKKKKJKKIJKKKKJKJJKKKKIHKKKCKJIKJG?KKJICKJKKJ8KKKIKKJKH?G=KKKKJK=KKKKEKJKKKKKKKJKKJKHK>KKH?KHKKKKJJJKKKKKKKIKKJKKKKKFKKIJKKKKKHKKKKKGJK>KKFHKKKKJKJKGKKKKKKFKIKKKJKKKKKK>KKKJKK0KKKKJKJKKJKJJKIKKKCKKJKIKKK6JKKKHKGIKHKJJKKKH1FIKHKKKKJEKKI:KGKKJ6KBJKKKGKKIDIJKBGKKHIKJIFKFIJIKDK3FHJKKJHJK4KKJJ@KKKKFIIK>KIAJKG;GAKKGHJJJJKJKIJKJKKKGKG;KKKJDJE?FKGKEKIKJKKKKJKIKKKKJKKK@;EJIG;KKKKKKE7KKKIKHKJIFKIKJKHKKKKK+KKKKKKKKKKKKJD;JKJKHJJKKKIKJHIJJ6KKKJKKIBKK7KKJ?KKJ6EBKK0KKKKKHKJKIKJKKKCJJDHGKJIBK=FKJJKJKKKFKKJDK?KKKKKKKJHKJCIKKKFKIIJKJKKKJKKKK(KEJJHKIKHKKAIKJIAJIJK:KHKJIKJ;J.=;EGHIC?KJKJJHK4KJK@KBJJJJDKKKKJ;J8KF9KKKFKKKJ;JK6KKFHEJJIGKKKKGHKBKKH5KKKKKEKJBKKKKKJKKAKKDKAKHBJI*JKJJKIKKK@KKKJKKKKCKKFFKKK:KKJKEJBHKJKHKKKII @rCer/120/25_1939_CCS ATGGGGGAAAGGGGAGGGGTGCCTGGAGAGGCGGAGGCTCGCGCGCCTGCGCATCCAGCTCCAGGGACCCTAGATTTTCTATGGGATTCCCAATCTGCAGCAGAGATTTACCCGAGCGTGTTGCGGCAGCGGCTGGGCTTGCTAGGCGCTATCCAAGAGGGATTTAAGCAGCCCAGAGCTCCGGAGAAAAAGAGAGCGAGAGAGAACCACACACGCTTAAGCGTTTACCCGAATTAAATATATATTTTTAAAAAGAACTGTTGAGTTTTATCATTTTCGTTAAGTGACGTGCGCAGCGCTATAACTGCAGGATGGGGAAGCAGAATAGCAAACTGGCCCCCGAAGTGATGGAGGACCTGGTGAAAAGCACAGAATTTAATGAGCATGAACTCAAGCAGTGGTACAAAGGATTTCTCAAGGACTGTCCAAGCGGGAGGCTGAATCTTGAGGAATTTCAGCAGCTCTATGTGAAGTTCTTCCCTTATGGAGACGCCTCCAAGTTTGCCCAGCATGCCTTCCGAACCTTCGACAAGAATGGCGATGGCACCATCGACTTCCGAGAGTTCATCTGCGCTCTGTCCATCACCTCCAGGGGCAGCTTTGAGCAGAAGCTGAACTGGCCTTCAATATGTATGACCTGGATGGTGATGGCAAGATCACCCGAGTGGAGATGCTGGAGATCATCGAGGCTATCTACAAAATGGTAGGCACTGTGATCATGATGAAAATGAACGAGGATGGCCTGACGCCTGAGCAGCGAGTAGACAAGATTTTCAGCAAGATGGATAAGAACAAAGATGACCAGATTACACTGGATGAATTCAAAGAAGCTGCAAAGAGCGACCCTTCCATTGTATTACTTCTGCAGTGCGACATCCAGAAATGAGCTGATGTCAGTGCTATGGACTGCACAAAAGTCTCAATGTTCCATTCAGTCTGCAGCTATTCACACACACACACCCACACCCACACACACACACACACAAATATTGCTTGGACTACCTATAAATGGACTTGCTTCTTGTGTTTGAAACACTTGTGTGCATGAGAATGTCATTTGCTAATGAATTTTAAAAGCATATATAAAACAAAACAAAACAACCTGCCACAATGTGATATGTGTAATATCATTTCATAAAAATCCCTCTTCCTCCAAAGCCTGGGCAGAAATGTACTGCAAAGAGTTATATGATTTCTTGTTCATGTTTTGCTAATGCTTGTATCTCCTTGATTACATAATGTTAGTAGCACTGAGACCCCCACGGTAATGTAACTTAATTATAAGCTATGTCACTACCCTCCTATAAAATAGTATTGGACAGACACAGAGGGACCCTTGGCTCCTGTGTCTGGTCCACACACCACAAGAGCTTGTATTATCAGTGAATATAAATGTACTACATTTGCATGCCTTTTGGGTTTGCCTTAATTCTTACCTCATTTGCATCCTATCGATCTGGAAAGAGCTGTTTTGGATGAATGCAGTATAAAATGTAAAATCCCTGCTAAATGACTTATTAAGTATATCTATCTATATATACATATACACAAAGATATTATTTATCAGAAGTAAAAAAGATGGAAGTGTATTGGTTTCTGTTTGAATTTTCAAAGGCTTCCAATGTGGTGGCAATAAATGTCCCAAATAAATTTATAACAATTGATTTCCCCCTAATTCTTATTTTATAATTTTAAAATAGCAGCAGATGCTAGCAACAACTTACTAAATCTACTCTTAAATACACAACTTTGGAATTTGAAGAATAATGACAACAAAAGGGAAAAAAGCAACTTTCCAGCTTTTCATCCAGGCTCCCAAAAGAGGGACAATGAACACGGCATGTGAAAAGTAGAACAGATTTGTTCATCCGAAAAAAAATGTTCATTCTCTGACAATAAATTCTATCTCAGTGT + 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@rCer/122/0_1078_CCS CAGAATATGCAGTCTTTGAGACGGGTGCCGGCACCATTTGCCCAGGCAGTGGGCAGGAATATAGCCAATCCCACAGCCATGCTGCTGTCGGCTTCCAACATGTTGCGGCATCTCAATCTTGAGTATCACTCCAACATGATGCAGATGCAGTGAAGAAGGTGATCAAAGTTGGCAAGATCCCATCTGCTGTTCCTCTTTCCTGCTCCATCCACTGCCCTTTTCATGGCCATCTGAATGCAGAACTTGCAGCTCTCCTTGGGGGTGGAACAGCAAGGGATACAGGCAGGCTGAAGCATCAGCTTCACCTTCACACCCATCTCCTTTCCGCTGCGATTCTTTCCTTCCACCTGGTCTTGTCTCTATTTCTTCCAAGGAAGGTAGCCACATTGCGCCTCTGATCTGCATTTCCCATCATCTTTGCCTGCTCAGCCTCCTGTCTGCTCTGGCTGCAGCACAGCTAATAGTGGCTTAAGAGGAGTGGGCAGGTCCATGTGCTTCCCAACCTGGCTCCTTCTTCCATTCCTGTGCATTGCCTCTTTTTCTGGCTGTCACGCATTCTTGGATTCCATTTCCTCAATCACATGCCCTATCTCCCTTCATGGGCTCTCTTTTCTCCCTCCCCACGGCTGTTGCCGGTGGTGGCTGTAGGTGCGGACTCGAGACATGGGCGGCTACAGCACCACAACCGACTTCATCAAGTCTGTCATCGGTCACCTGCACCCCCATGGGAGCTAGAGCCCTTTATTTCTCCAGCCTTGCAAGGACCACACTCCCATACCTTCAGTGCAGTGCACCAGGGAAGAGACCTTGTGCCTCTAGCAGTGGACCATGGTCACCTTGCTGGGTAGAGCCTAGGTTGTCCTGGCCCGCTTCCTTAGGGGAGACTGTTGGGTGGTGATGGGAATTGTTAGGCTGGACCCAGGCCACATGGATGATGATGATTCTCCCCACAGGTTCGAACCTCTGACATGGGTGGCTATGCTACTTGCCATGACTTCACTGAGGCTGTCATTGCTGCCTTGCCCCACCCATAGGCCTTGTCCATACTCATGTAAGGTGTCCAATAAAGAACATGAAC 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TAACCTCCCTGTTTCCTATGAATCCGGGCAACATACCCCCGATTCCGTTACGACCAACTTATACACCTACTATGAAAAAACTTCCTCCCCCTCACACTAGCACTACTCATATGATCCACCTCAACACCCATCGCAATCTCCAGCATTCCCCCCC + S$#%%$%+)(%#(&'-,,(&#*()/&.22/433+106466433645456)462,505/46,4-44%./2501./-/0/)/004+2))355.5402305445124434263541.4)5.()-4.453,4.2/525-6552/45112561256466 @rCer/125/25_3486_CCS ATGGGGAGGAAAGCGCAGAGAATCGCCAAGAAATCAGGGTGCTCAGCCGTCTGCAGGTGTGGACCCAGGGCCCAAGCCTGTGGCTTTCAGTCAGCCCAGTCCGCACCTCTCCCGTGGGAGGTGCTGAGAGCACGGGACCATCCTGGGCCCCTGGGATCTCAGAGGCTGGACCTTCCTGGGAGACTCAGGAAGTCCCACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCTTTCTACGAGGTCCTGGGCCTGTCACCCTGAGGACGTGATCGAGGAGATCATCAAGTCGGAGATCCTGGATGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGCGACTTCTCCGCCTTCAAGGATACGGACAGTGAGCTCAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCTGCTCATCGCTTCCTAGCCACAGAGGTCCCCCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTGCTCAAGTACCCAGATGTTATTCAGGAACTCAAGTTTGATGAGCATAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATTCTGCAGGGGAAGGTGGAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTTTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCTGACCGTTCCCCAGCCCACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACGGACATCTCGACTGCATCCGCCTTGGCAGGCAGCAGCAACCAGTTCGGCAGCTCCGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCGGGCCCTCGTGGACTTGCAGTACATCAAGATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCCTCGCGCATGGAGAACAGCCCTCAGTTTCCATAGACGGGTGCACCACCCACATGGAGAACTTGGCCGAGAAGTCTGAGCTGCCCGTGGTGGATGAGACCACGACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCCCACGAGAGTGCCATCTGACAGGAGGGCCCGGACCCCCCGCCTACCCTGCGGGGGCCTCCCCAGTGGGCCCAACATGAAGAGAGGGAACCTGTTAGTCCAGAAAGGTTGCAGATAGATAGCCTGTCTGATTGAGCAGCCAGATGGCCCCCAGCCTGTGGGGGATCTGGCCTCTGCCAGGGACCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGATGGGGCAGTGGGCCAGCTACCATGAGCAAAGGCTGTTTTTTTTACTGAGAGTATTTCTAAACTAGGCTCATCGCTCTTCTTTTTAAATATAATTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAATTTTTTTTTTCCTAAAAACTATAAAAGAAGAAGGGTTTCTTGTCCTGGGAAGCAATGGACATGATCTGCTCCCAGCCATGGCCTTCCAGCTTGTGTCCCTGACTGAGGGAGCTCTCCCTTCCCCCTCCTCTTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCGGCAGAGGCTCGTCTCTTGGAAGGAAGACAGCTCTTCACAGGAAGCAAAGAACCAACTGGCATGGAGATCAGCTGCCTGGGCACCTGCGCCGTAGCTTGTCTGACAATGCGGAGGCCAGGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCCGAGCTATGGAGAGGAGCACATCTGCTGTCAACCGCTGTACCCAGAAATCTCCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCAGGACTCGGCTGAGGACAGACACATCCCCCCCCCGCCTCCCATCCAGCCCTTTGGACAACTGGCCCCTTCGTGACGGGGCAGACTCAAGTGTTAGCAGGGTCTCAGGCCTTCGATTGCTCACCCCTGCTCCCTAGGCCTGCCCTCACTGTTACCAAAGGTTCCCCCTCGGCAGGAGGGCATCTACGTTGGAGGTGACTTGTCTAGTTCTTCCTTTTGGTTCCGGGAGGAACTGTCAGTCATCGGCATCTGCATTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGAGAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTCCCCAGATTCCTTATTTCGAATCCCCAAGCCTCAGTCCCTCTTGGGGATGGGGACAAGAGGACGTGTGGGAAGCCACGGAAGCAGGTTCTTTATGTCCTTTCCTCTGCGGCTGGCAAGGCTCACCTGGCCTTATCCACCCCCTTATGGAACCTCAGGAGAGGACAGCTCCTCCTAAAGGCATGCAGCTTGCAACCCTGCTTTCTCACAGGCGTGATCCTAGTGTGAGAGGTCGTCCTGCCCTTGCTGAAGTTAGTAGTACTGTACCAAGAGCTCTGCCCCCATGTGAATTGCTACCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAGAACTCCAGGTTTCCCAGAGTCGGGGAGGCTGTGGGACCAAAGGTCCCCGTTGGCCCTTCTGCTGGGTGCAGCAGGAGCTGGGTCCTGAGAGCCTGGCCAGTGAAACTGCAGGCCTTCCGCCTGAGTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGAATCCTAACTCTTAGGACCAGGGATTGTCTTGCACCAAGTATGCCTACCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGACGCCTGGAGAGAAGGTGGTGACACCCGTGGGTTCTCAACTTTAAGGAAAAAAGACACAAGACTTTTGTTCCCTATTGGGGGAAAGCCTTAGTCTTCTCCAGGAGCAGCTTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTGTACTCCTGACAGCCTGACTGCCAGGTGGAGCAAAAGACGTTGGTGGGGGTGTGGGAAGCAAAAAGGGGCAGGTGTACACACCTCCACAGTGACCTCTGTGCACACGGTTACCGCCAACTGGCTGACCCTCCTCTTCCCTGGTCCATTGATCATCCTTCTCACAGAGGGTCATCATTATTTCCAAATACTGTTGGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCACTTCCTATTTCAAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGTCCCGCCCGCTGTGTCTTCCGTGTAAGGGAGACCTTTGCAAATGGCATCCAAATGGGTAGGCAGGTCACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTGTGATTTACTTTGGCGTTATGAGTTTGACTCTCGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATAATATTTGCTAAAGGATATATGGAATTTATTTTTGATTGGTAATAAAAAATGAAATATG 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@rCer/126/25_2042_CCS ATGGGGCTCGGCAGCAGCCTGTAGCCGCTGGAGCCGCCGCTACCTTTTCGTGTCCGCGTGGCGCCCGGTCCCCGCCCGCCGCACCATGGAGGGCTACCACAAGCCTGACCAGCAAAGCTGCAAGCCCTGAAGGACACGGCCAACCGCCTGCGCATCAGCTCATCCAGGCCACCACGGCGGCGGGCTCTGGCCACCCTACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTCCACACATGCCTACAAGTCCCAGGACCCCCGAACCCACACAATGACCGCTTTGTGCTCCAAGGCCATGCAGCTCCCATCCTGTACGCGGTCTGGGCTGAAGCTGGCTTCCTGCCCGAGGCGGAGCTGCTCAACCTGAGAGATCAGCTCCGACTTGGATGGCACCCGGTCCCCAAACAAGCTTTCACCGATGTGGCCACTGGCTCCCTGGGCCAGGGCCTTGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACGAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCCGTATGGGAGGCCATGGCCTTTGCCAGCATCTATAAGCTGGACAACTCGTGGCCATTCTAGACATCAATCGCCTGGCCAGAGTGACCCAGCCCGCTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCAAGCACCAGCCAACAGCCATCATTGCAGACCTTCAAGGGCGAGGGATCACGGGAGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCAAAAATATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAAAGCAAAAGAAGATCCTGGCAACTCCCCGCAGGAGGACGCCCCCTCAGTGGACATTGCCAATATCCGCATGCCCAGCTTGCCCAGCTACAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGAGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAGGAGCACCCGGACCGCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACACGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGTGGCTCCCACTGTGGCGTTTCCATCGGGAAGACGGCCCTCCCAGATGCCCTGGAAGATCTGGCCATGTTTTCGATCAGTCCCCACGTCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCTATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACTGTGATCGGGGCTGGGTGACCCTGCATGAGGCCTTGGCTGCCGCCGAGTTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCGCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGATCCTCACCGTGGAGGACATTATTACGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCTGGCATCACTGTCACCCACTTGGCAGTTAACCGGGTACAAGAAGTGGGAAGCAGCTGAGCTGCTGAGATGTTCGGTATTGACAAGGATGCATTGCACAAGCTGTGAAGGGCCTCATCACCAAGGCTAGGGCGGTATGAAGTGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGTAAATATATGTTTTGAG + 781;89/16*:8399>>7858675:89=03;50(2.27<81853*9::73796469:44'%=9'97-:.2:;:.3<<89=:;;,9/=8=6%349+97=584=1,>/3638025#%.74238.33&8:'79=8;9;9<)<76;=-:/183::78:<;751/$39:==(5+982=0:6=:(79);940,(2=*4+/=>047:990--42/00$.2/5553:-61:;36,:31646<-.&7<;(3=86$89>7$:52,@':%<:7(?-/GGF2(5?4@@56.8+:.=88A=3/>:822))+%0<&<$5A67@=+:70;?70-A>A9898-+;24+%<<6:91@2*0/>A,B.8=@5CC<9;>?.=68=;887=4:>C)98('5A1A=(AA,'ABA>DDC)@<9):CB;8<5/G.C4EE)99?'?C/6;C6E@@9BE>9*?5F>*7<,:2ED8DE1BB3FE?A.8<6@9E5*@88:C981;B<83<=A:DEEB5G?;AB;&?907493@BD1023ED+<8DDEC8=CCE4E>B;8=C?E4DD?;D3@4?BDABA0F2>.A1:9B:BBAA8>;C5@82D;E-D229?8F>B?A>8;C7FC4.?506:0=AB>E@7AE6D@A8G.:&?-2B%8/CA2*$3D?;40DC:%7->,1<6D27?4::<#%/77?9A3/?%6$&59&@@%0)*.3>?0864;(<642&02?3471-16C>>/(:;5=3'67<(*>:*78;7142,B-3=<=@498B2;=/C<5C,5>7/:%205+>38,A=@-A=;>$?>>//>527*@;11/?C?C:::.=<(@%@3:=5=>B5494B<:?=1A=3@@537?<5(=<.=*>>:2>3B=7=<-+@5-=::9.?8C-@1<;96:.A+?2?9?7-A>2><8?)97@B;<3?@63>=0@@=,<>37=<=;B>==;><<4A&60+<'5&3:.=59<=B9A:'<@<:A7*350>@$7=@CA77A?A@@>6-<.166;-,;=83@9A72:9B9.:=?AA;@B?:7@@8>@9CB??A;?9C;8B>8:+>A<-=5<9@;>4CC1B-5::;778;&==>>81=5>,:95:4-3-<8CB;C4CC=7<.4717>>8@..>,>695=6:@<6,79><6=6;C::2=>6;866-??+;7*:$=.=C&):;@?1+&9?C1=;=?&<=<>>?:87=0(@BA781<>0?<9;8@+:<<;)AA*B,585@7B>B;CA&4?2/(@2;2:>3@5569)><+=.=465&;958@?>717B>;6?:;@206C?9@@3B)>>25>>9;@968;;BA>C91A@8=;4:3C>?18.77;?;A499B2AABC0>1;70;$+@?>?C??5<<8:?>=974=4/9<7:@>?6A=AB-@BBA-*A?:B>C?4AB<,>?@@?C@0BB=8=>>@C75?,?47?861->;:>@'>=>6=>9<>14:0.;/<7?&>;8?4C3:B?2&9@;B3;<'>563A/7C7%,4::7>:>7)<:=-8305++4,=6;95-#138=48748469;=/::174=;?=;17=3:8?9;970(6870>:9'83)43$58)7897:;7+97*378008717928=;+;/>*8044%;:==754)<8::>>?:;1=609132876'42=5:%-05?=;%42/36+63;;+*7:>=):558=<77768:6>%7/7403;<97%6405=;?=:=:<4<<<=78;54,85.33:0$855+584/..48-:9:::6 @rCer/130/25_2207_CCS ATGGGAGTCTGAGGCGAAGCTTCGGAGCGGCCGGTACTGTTGAAAGCGACAAGTGGAGGCGCCGCTTAGCGGCCGGGACTCTGAACTATGGCGGCTAGTGATACAGAACGAGATGGACTAGCCCCAGAAAAGACATCACCAGATAGAGATAAGAAAAAAGAGCAGTCAGATATATCTGTTTCTCCTAGAGCTTCAAACATCATTATTCAAGATCACGATCAAGGTCAAGAGAAAGAAAACGAAAGTCAGATAATGAAGGAAGAAAACACAGGAGCCGGAGCAGAAGCAAAGAGGCAAGAAGACATGAATCCAAAGATAAATCCTCTAAGAAACACAAGTCTGAGGAACATAATGACAAAGAACATTCTTCTGATAAAGGAAGAGAGCGACTAAATTCATCTGAAAATGGTGAGGACAGGCACAAACGCAAAGAAAGAAAGTCATCAAGAGGCAGAAGTCACTCAAGATCTAGGTCTCGTGAAAGACGCCATCGTAGTAGAAGCAGAGAACGGAAGAAGTCTCGATCTAGGAGTAGGGAGCGGAAGAAATCTCGATCCAGAAGCAGAGAGAGGAAGAAATCAAGATCCAGAAGCAGGGAAAGGAAACGGCGGATCAGGTCTCGTTCCCGCTCAAGATCAAGACACAGGCATAGGACTAGAAGCAGGAGTAGGACAAGGAGTAGGAGTCGAGATAGAAAGAAGAGAATTGAAAAGCCGAGAAGATTTAGCAGAAGTTTAAGCCGGACTCCAAGTCCACCTCCCTTCAGAGGCAGAAACACAGCAATGGATGCACAAGAGCTTTAGCTAGAAGGTTGGAAAGGGCAAAGAAATTACAAGAGCAGCGAGAAAAGGAAATGGTTGAAAAACAAAAACAACAGAAATAGCTGCAGCTGCAGCTACTGGAGGTTCTGTTCTCAATGTTGCTGCCCTGTTGGCATCAGGAACACAAGTAACACCTCAGATAGCCATGGCAGCTCAGATGGCAGCCCTGCAAGCTAAAGCTTTGGCAGAGACAGGAATAGCTGTTCCTAGCTACTATAACCCAGCAGCTGTGAATCCAATGAAATTTGCTGAACAAGAGAAAAAAAGGAAAATGCTTTGGCAGGGCAAGAAAGAAGGGACAAATCCCAATCTGCTGAAATATGGGAAAAATTGAATTTTGGAAACAAGGACCAAAATGTCAAATTTAGGAAGTTGATGGGTATTAAGAGTGAAGATGAAGCTGGGTGTAGCTCAGTTGATGAAGAAAGTTACAAGACTCTGAAGCAACAGGAAGAAGTATTTCGAAATTTAGATGCTCAGTATGAAATGGCAAGATCACAGACCCACACACAAAGAGGAATGGGTTTGGGTTTCACATCTTCAATGCGAGGAATGGATGCAGTTTGAAAATGATGACACTTGTAAAGTTTGGGACTTATAGACTTCTTGTTCTGATGTCAGGTCCTTGTTCACCAAACAGCTAGCATTCTAGCTTGCATGGGTGTTGCATTGACTTAATTTATTGAAAAATACAAATTTTTGTAAATATCAGATCAGTGATACTGGTGTTAGTGTTGTAATCAGGTTAAACCCACTTCCATTAAACTTGACAGGACTATAGAAGGACAATATTTTTTAGTTCATGAATTCTACTTTTCAAATATATAAAAGCTGCAGGTGGGATAAAATCTCATACATGGATTTTTTCGTGTCCGCTGTCTTGTGTACTTTTGTACTTAACCTTGTACAGTTATTTTCATCTCTTGAACATGAAAGAAATGTTATGTAGATGTTCTTTAGAAGATCTGGCCATTTGGTACATAATCCAGCACAGATAAGCTGGGTGGTGATGACAATAAAAATGGTTTTCTCAAAACTGGTGTTAATTTAAGTTACCTGGGATGTTTCTTTGAATTTGTTTTATGGTTTCTGTAGCATTTGGCAATTGCTGTTAGAAAACACTAGCTAGAAATCACCCCCACCCCGGCCCTTTTAAGGCCAGTTAACTATACTACAGGCAATACCATGGTGAGCAAAAATGTAAAAGGTGGGAGGAGAAAACTTATTAAAATAGTATGTTTTCCTATTATAAGGGACAGACTTGGTATTCAGTGTTTGTCAAATATTACATGTGTTATTCAGGAAATAGATTAATGCATTAAAGGGATGTAAGCACTTTTATTTTAATAAAGTGCCTTATG + D@7GDAEF=9DD8A;@+CB@@FBCE:2:8A?:DD@FGE9@CBA@EBAE?78C@C@DB@AGF3GFC54<<;EEC?F@EBB<7;A4=@=?BC?@A+B?=?EC@BA@@>AGE8FADD2?A*?>6<;=C5@D.75=ECEBC8CB4AB/?3B?;:BA2C1BCB(@AACF:EFA@?;D:@9C;@6B+60?3%7<=:>@B3F7=9D=F@0C@955ABA5F%B@=88'@AA5DB?8:@B9BA?7?B?C;?;EAG>:9A@?=<@-A@<<@D??B:->A98/63GEEF=F&;@CCE@@CA:?BDCD=<=C?0A7C@:F?@<,BBA@>CE@B7@EBFA&>>=8?>@5AA>=8:E>/:8?77??>:?:2?;B/@%B2B?C:CF@4CA@>AB4@DECCA9?::E9B@E94::5=ABC9EBCC=E@>DG47;EG<8A5EF=?ED?F6>E9EBDEC??9EEFD=6AEF;DE=A9C8$??7@DFG@A?EC,A0=FE<:B??DBBC+D;BFFFF=B;@993>;36?A9BA.EFFE2@=AC;>FC+D>7CF:E@;@;FE?EC5GFGGE?7B>FA95DCEG<0<>6?@A@:69+:@'9<<4><8?7=;>?9>?@;>1=:#9<9CEECB?:A39::&B/F2AB9EGD?B@C8>E9@;D*?D>?;BAD@AFE<5>=A><,;@>;59:@%0/6B86@;::C>ABA@@E;7;9AD9<)6:38?6<7=>818B@*C-CB<;AEBA9CEC?3:A=0;>A?BBB3:3==BBE>>8>7EC?>5D2;:B@BC=+D:A=E?39>BC7(9G1CDGGA42;CBCB6FFAE>IEA6A@7@@=??B>B>@DDCB1>FHHHC9F4JJJFDA*B?>C<9:EHF@D9'B;>36&?C@H,HD?:GHFGFG3AE??7FDD@>=EC6?ED?:DD6B5BGFG:AAEII@7DEDE7EFAE=ECDD1F:EFIFCF?JGGGHFIH@D&DCB=DBD@=@EA6GB?HI4GH-BAEAJEG?GDBGDDA?>FFD3EC6EB?BHFA<8E;E@BDGFEG8FGEG>GB?E6HG4JI8JE8FI@>AG?B>GF8D7CIIH2EB:8HD?4BE?.=@5EFBDGIDIGIH<<@?EGGFJFDHBBDICIAJHAI>GI3ACF<5,8DDFEE+CBDHDFBBAF@FFA:AD1@FGE3D9FG>H@GC$>-5?ED@5>C8@FHHCFI0HG%=>>AA<9BEDBC-<@>EHEHBH@C@?<0F9B8A@FFH>C?DFIGGFGICHGE<@E?ECHEI>C/>DA%E@@CEDIDGE=):>FCE@:AD4FAFC4DC?CC9:1DBHFHD=GFEFH/@AD>9GIG@D>DDFC?EHEH;(FEFG=;E?EEDGG:EA0C*AFDBFEE5FIEGC:EAIHF?B?DDDG3E?9G2IDIIGE2=HFE<.FD4BA0EEHHG5?BE1C@8CD?;ABBCB;<7?IGGDIGAJJBDEDBFDH==GA/DIH>=EB<>(<>;:AAA3=D2A>IBIDG=?G9CEA'HDJDI8FE=?=9+3@GE?(@>C6A;?CA?2BDG?H9CA=CB@6F?FHF@E8C9IJ&@B@6>DC @rCer/131/25_1772_CCS ATGGGGCAGATGACCCCACTTACGGAAATAGCGCCAAGTTAGTGTACAGTATCCTCGAAGGACAGCCCTATTTTTCGGTGGAAGCACAGACAGGTATCATCAGAACAGCCCTACCCAACATGGACAGGGAGGCCAAGGAGAGTACCACGTGGTGATCCAGGCCAAGGACATGGGTGGACATATGGGCGGACTCTCAGGGACAACCAAAGTGACGATCACACTGACCGATGTCAATGACAACCCACCAAAGTTTCCGCAGAGCGTATACCAGATGTCTGTGTCAGAAGCAGCCGTCCCTGGGAGGAAGTAGGAAGAGTGAAAGCTAAAGACCCAGACATTGAGAAAATGGCTTAGTCACATACAGTATTGTTGATGGAGATGGTATGGAATTGTTTGAAATCACAGCGGACTATGAAACCCAGGAGGGGTGATAAAGCTGAAAAAGCCTGTAGATTTTGAAACCAAACGAGCCTATAGCTTGAAGGTGGAGGCAGCCAACGTGCACATCGACCCGAAGTTTATCAGCAATGGCCCCTTCAAGGACACTGTGACCGTCAAGATCGCAGTAGAAGATGCTGACGAGCCCCCTATGTTCTTGGCCCCAAGTTACATCCATGAAGTCCAAGAAAATGCAGCTGCTGGCACCGTGGTTGGGAGAGTGCATGCCAAAGACCTGATGCTGCCAACAGCCCAATAAGGTATTCCATCGATCGTCACACTGACCTCGACAGATTTTTCACTATTAATCCAGAGGATGGTTTTATTAAAACTACAAAACCTCTGGATAGAGAGGAAACAGCCTGGCTCAACATCACTGTCTTTGCAGCAGAAATCCACAATCGGCATCAGGAAGCCAAAGTCCCAGTGGCCATTAGGATCCTTGATGTCAACGATAATGCTCCCAAGTTTGCTGCCCTTATGAAGGTTTCATCTGTGAGAGTGATCAGACCAAGCCACTTTCCAACCAGCCAATTGTTACAATTAGTGCAGATGACAAGGATGACACAGCCAACGGACCAAGATTTATCTTCAGCTACCCCTGAAATCATTCACAATCCAAATTTCACAGTCAGAGACAACCGAGATAACACAGCAGGCGTGTATGCCCGGCGTGGAGGGTTCAGTCGGCAGAAGCAGGACTTGTACTCCTGCCCATAGTGATCAGCGATGGCGGCATCCCGCCATGAGTAGCACCAACACCCTCACCATCAAAGTCTGCGGGTGCGACGTGAATGGGGCACTGCTCTCCTGCAACGCGGAGGCCAGCGCCCAACAGTGTGGATGTCGATGACTTCATCAACACAAGAATACAGGAGGCAGACAATGACCCCACAGCTCCTCCTTATGACTCCATTCAAATCTACGGTTATGAAGGCAGGGGCTCAGTGGCCGGGTCCCTGAGCTCCCTAGAGTCGGCCACCACAGATTCAGACTTGGACTATGATTATCTACAGAACTGGGGACCTCGTTTAAGAAACTAGCAGACTTGTATGGTTCCAAAGACACTTTTGATGACGATTCTTAACAATAACGATACAAATTTGGCCTTAAGAACTGTGTCTGGCGTTCTCAAGAATCTAGAAGATGTGTAAACAGGTATTTTTTAAATCAAGGAAAGGCTCATTTAAAACAGGCAAAGTTTACAGAGAGGATACATTTAATAAAACTGCGAGAACATCAAAGTGGTAAATACTGTGAAATACCTTTCTCACAAAAGGCAAATATTGAAGTTGTTTATCAACTTCGC + KK)KKKKKKKJKK7KKKKH?EKK&I9KHCJGKK;KBKKHKBJIKHGKDB=>EICEJ7?AB?=KIJAHAHKGJJDFKKKKKKKKKJKKK7KHJ5KJJ4KEKIKHBK6IH?JKKGKKKKK,KKFH1KH@GHCKKK%IK9JKKJGKK?KKKJGKJKKKKJKKJ:KJ*KKK?IKKBKE9KEK?CK@K-EG9KKJ5KKJGHGB4KKIKGK-KKKKKEKIKKJ7F9KKKJ0KKDK@KKKEJIHKKKHDKJJKIEK=KKGKK>KKKK2KHKKK@GKAFIJKKJEKHKIJ>GKKHFKHKEFE6:K$KHHFKEEK5DFG2H0D16IAKKGK7KD@KJKIFJFGK=KFDFKKEKJKJ@@&GKKKJJ5H*JC:K=K)KKK(KG0KKJEKFKC>JGJIJ6K;JF&KJKJIKKKIKKCEKKJ:=KJFBK;K4KKJEKKKHKCHI9K6KJKJ'I3BEHKKFKAKBKKKGFJKICHFK.KKIFKFKJBK;HK&KJ?HJKKKJKK9KJKKGFEHI7KKK8KIKKKKJ=KIFKKHKKKKKJK5KKKC5KKCJGBKGKKK>KF2KKJKIK&KKCJD9KGK9K6KKIKJG?GG?GFFJJKKKIEHKKGKEJ=K4K%KB1KGK;K3KHKKKKJKKF>JKBFFKGJJGKBJ>KGKCKKIKG'JE.I9KEFKKK@KKKKJG,JEJG:K@KF=EIE6J*GJDKJEAK=JJIIGFA(JK6KKKCFKK5EIDKGJHIJ;EKC6JKKIEBAKFFEJ:JFBKDKFKJ5H63K9KFGII-HHEKJKGGHKIKIHFBIJIJHJIFKJ:IJ7KGKJIHKFH3KEJFJHK:I:GKD6FJBF;J@BFKK>EBF5@K;JFK?IKKJDIJAKJJAFC@JGKHC8AAGDII>EEFKKBJFKF?5KJIIAKJ@E)J>>KI7KKJJHKH@FJFIKKCAEAKJKIK;KKKJKC?,KKKHIJJDKK=*IF.J&F98KJ:HIKDHGHEJEBHKBK8K:KEKKKKJ=JEDCJE4KKJ6KIBI2JJCKED0IG(BDGKIII=.KKIIJKFF&KKGA=2;FHIHK7KDKK?KJBGJ/J@'JFIKJ?KKGHKJKKGKIKJ @rCer/134/1914_59_CCS ATGGGGGACGTCGGCGCGGGCTGCACCGCCGCGTCCGCCCGCCCGCCAGCATGGCCACCACCGCCACCTGCACCCGCTTCACCGACGACTACCAGCTCTTCGAGGAGCTTGGCAAGGGTGCTTTCTCTGTGGTCCGCAGGTGTGTGAAGAAAACCTCCACGCAGGAGTATGCAGCAAAAATCATCAATACCAAGAAGTTGTCTGCCCGGGATCACCAGAAACTAGAACGTGAGGCTCGAATATGTCGACTTCTGAAACATCCAAACATCGTGCGCCTCCATGACAGTATTTCTGAAGAAGGGTTTCACTACCTCGTGTTTGACCTTGTTACCGGCGGGGAGCTGTTTGAAGACATTGTGGCCAGAGAGTACTACAGTGAAGCAGATGCCAGCCACTGTATACATCAGATTCTGGAGAGTGTTAACCACATCCACCAGCATGACATCGTCCACAGGGACCTGAAGCCTGAGAACCTGCTGCTGGCGAGTAAATGCAATGGTGCCGCTGTCAAGCTGGCTGATTTTGGCCTAGCCATCGAAGTACAGGGAGAGCAGCAGGCTTGGTTTGGTTTTGCTGGAACCCCAGGTTACTTGTCCCCTGAGGTCTTGAGGAAAGATCCCTATGGAAAACCTGTGGATATCTGGGCCTGCGGGGTCATCCTGTATATCCTCCTGGTGGGCTATCCTCCCTTCTGGGATGAGGATCAGCACAAGCTGTATCAGCAGATCAAGGCTGGAGCCTATGATTTCCCATCACCAGAATGGGACACGGTAACTCCTGAAGCCAAGAACTTGATCAACCAGATGCTGACCATAAACCCAGCAAAGCGCATCACGGCTGACCAGGCTCTCAAGCACCCGTGGGTCTGTCAACGATCCACGGTGGCATCCATGATGCATCGTCAGGAGACTGTGGAGTGTTTGCGCAAGTTCAACGCCCGGAGAAAACTGAAGGGTGCCATCCTCACAACCATGCTTGTCTCCAGGAACTTCTCAGCTGCCAAAAGCCTATTGAACAAGAAGTCGGATGGCGGTGTCAAGAAAAGGAAGTCGAGTTCCAGCGTGCACCTAATGCCACAGAGCAACAACAAAAACAGTCTCGTAAGCCCAGCCCAAGAGCCCGCGCCCTTGCAGACGGCCATGGAGCCACAAACCACTGTGGTACACAACGCTACAGATGGGATCAAGGGCTCCACAGAGAGCTGCAACACCACCACAGAAGATGAGGACCTCAAAGTGAGAAAACAGGAGATCATTAAGATTACAGAACAGCTGATTGAAGCCATCAACAATGGGGACTTTGAGGCCTACACGAAGATTTGTGATCCAGGCCTCACTTCCTTTGAGCCTGAGGCCCTTGGTAACCTCGTGGAGGGGATGGATTTCCATAAGTTTTACTTTGAGAATCTCCTGTCCAAGAACAGCAAGCCTATCCATACCACCATCCTAAACCCACACGTCCACGTGATTGGGGAGGACGCAGCGTGCATCGCCTACATCCGCCTCACCCAGTACATCGACGGGCAGGGTCGGCCTCGCACCAGCCAGTCAGAAGAGACCCGGGTCTGGCACCGTCGGGATGGCAAGTGGCTCAATGTCCACTATCACTGCTCAGGGGCCTCTGCCGCACCGCTGCAGTGAGCTCAGCCACAGGGGCATTAGGAGATTCCAGCCAGAGGTCGAACCTTCGCAGCCAGTGGCTCTGGAGGGCCTGAGTGACAGCGGCAGTCCTGTTTGTTTGAGGTTTAAAACAATTCAATTACAAAAGCGGCAGCAGCCAATGCACGCCCCTGCATGCAGCCCTCCCGCCCGCCCTTCGTGTCTGTCTCTGCTGTACCGAGGTGTTTTTTACATTT + :=CGAB2=IIHCJ9:<6?=B::EG>@8ADA?A1?/BB:?89=A4@CC@@AB>CA:==BA80>>+?;GEB8BCE4:CDD@F;D>EBFBFFA9@A@?>:2'AEDIHHF@?AEBB?9@GIDCIHFHDFI7GHIB>FGFIGCDIJ@FBGBC>DH@FF@F1?EGF2BIFCBEE3=D8DHEFCADFFED?.AEHG;GII=HGHABB<@?A>=G??IBGCG7F?;<4:CBFFD9?>FE=F;+DCHDCE>8D?9=FHDHEGF>CIJFCG>AE>@ICHFEFIHFH>H?IFACDGG/BG:J@FDFBCE3EBA1@>@4E?CAEEHFF@DAGEFBED@>6+>DFE9?CDDA@>:@BA:CEBG8:C4E4>F6FCFDE3EDHHEC*FDFE,@CGDCEAD/BCC>A6HDCE@;9DDE@@GHC>BGHCA@FG6CFGFH?HDCBEFDHA>ECHI5JJDEBHAEECEDDFFI@HIFDHBDF7H?IICFC=DIDHCEHDEGGA3A?D=E=FB>;FECHIDGICIIFFEBEEDFB7DG9AC@GF,GDF8AECDABB7FGH:@FCDEGED@8G?>=CH8C@D6A?8=@D?D;FEJEHFCCHCH=@C6G;AA3CF#FEFGIFGEBDHCFAJGHE6DC=IAF?CCDBF;DGGFIIGG=GJ>@>A7DFCHH:HDF?9FBG=H?>F3HIE?E@=FHFBGHFB4FBBEFGICIHJHDIFA@AE1@HFG0G;HHIIIG;EHECGE=A?ACDF5DEFAA>FGAECB<2DDABCB?G:GFCC8D@GG@BAB@E>=;DD@ECC?BAEFAABFB??@BDC/FC>??E@@FBGC:;EFFFDFAEBGB@@FDA;CBBDB?E=?BED@C2?GBBDB>@3DGGA;@FGBBDADEGFCCDD@BC?5FD@BE:A2B==?E>DBBABADC8E@=5@7?@2>D@7BAFECBA>?/AEAEEFBFDGEEE>GCCA5GFB:=?8@BDC=ADGCDFA=FCC:@;77?GE8@=9FEECBBDA;DBB@A3FEC@=FGDD>C>DEG@CC:>@@BA=61FC>FFD=5?1D>EF7FFECC;CD?>EAD7A?E@ADBCEFCBFCGAG9ECCF?8EAGDE;DFACGGDFBF=FGCDB@EBDBECA@=GB=?C4@D>:DCEAA2EDEBEGE6DED@@D?EEAFF9E1DCECF?EFBE=@DGCDBD;FDABEA;AA;E;EDDFA?CBBC4CBE:;/BD9EGFDFDDBBCBGE>A?1D@=9ABEAGB9AB2?EFCADD><3=C?F><BDC?2@E @rCer/138/0_1165_CCS TCTCCGCAAATTTCCTGCGCAAGGTTCAGCATTTGAGGGTGACGATGGATTCTGTGTGTTTGAGAGCAACGCCATTGCCTACTATGTGAGCATGAGAGCTGCGGGGAAGTACTCAGAGGCAGCAGCCAGGTGTGCAGTGGGTGAGCTTTGCTGATTCCGACATAGTGCCCAGCAGTACCTGGTATTCCCACCTTGGGCATCATGCACACAACAAACAGGCACTGAGAATGCAAAGGAGGAAGTGAGCGAATTCTGGGCTGCTGGATGCTCACTTGAAGACGAGACTTTTCTGGTGGCGAACGAGTGACATTGGCTGACATCACAGTTGTCTGCACCTGTTGTGGCTCTATAAGCAGTCCTAGAGCTTCTTTCCGCCAGCCTTTCCCAATACCAACCGCTGGTTCCTCACTGCATTAATCAGCCCAGTTCGGTGTCTGGGAAGTGAAGCTGTGTGAGAAGATGGCCAGTTTGATGCTAAAAAGTTTGCAGAGACCCAGCCTAAAAAAGATACACCACGAAAGAGAAGGGTTCACGGAAGAGAAGCAGAAGCCCAGGCTGAGCGGAAGAGGAGAAAAAGCGGCTGCCCTGCTCCTGAGGAGGAGATGGATGAATGTGAGCAGGCGCTGGCTGCTGAGCCAAGGCAAGGACCCTTCGCTCACTTGCCCAAGAGTACCTTTGTGTTGGATGAATTTAAGCGCAAGTACTCCAATGAGGACACACTCTCTGTGGCACTGCCATATTTCTGGAAACTTTGATAAGGACGGCTGTCCTGTGGTACTCAGAGTATCGCTTCCTGAAGAACTCACTCAGACTTCATGAGCTGCAATCTCATCACTGGAATGTTCAGCGACTGGACAGCTGAGGAAGAATGCTTCGCCATGTCATCTCTTTGAACAACAACAGCAGCTCATTTCTGAGTCTGGTCTCCGAGCAGGAGCTTGCCTTCGCTGAGTCCAGATTGCAGTGGACTACGATCATACACATGCGGAACTGGATCCTGGCAGCGAGGAGACCAGACGCTGGTTCGAGATACTTTTCCTGGAGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATTCAGGCAAGATCTTCAAGTGAACATCTTTGCCATCGCCTAGCTGCCGCACTGCCTTCGGGAGATGGGGTCATTAAGGAAACTGAACATT + S,+/654)11(3/)/0/,%63:&543&4413/3571-65614::904:6-1&(0.566-:<006-61):60*78=?>/>=<36658773=:%9;6$.+0>;4,3.59?=27-(&1)4):66764)+>9-75$.595<1/::9533*'4891--49;&7+8534+46+$,013+006-,30)+16))$77&%&&3040%243'565-&-,*9,*4151,&$2/59933:664/:6(.3&644703(&82(7&974326:79,3%.(3:=:801*96-:7;:12$58/;>:=79;9$55908638*74:6+/5&3+4127::&,5586655355.&)14-0442+411176:28557&2993(3..((/209:(56698'-5,67+752:,214-99:758.9-8487-1&/51704/53:65/;88'&0/+2%6/4$$71*5179095/148,0187-7203&*&,53'67510546(8:::%%3579-32,,$0264&61'333000,)899'/0)#"%/342%0,::-:&0*(9$08:85;5687/62&.05&538-999(038'2,04/-:762&.*//.5,767-18&73:4472.3-0-40:0..+6498437/6+66915,:94331-63)4/2.-*,8'(3)89477:65::*+68&02*935077+0(28188.34737-29,83146678665'.(,'477819-:17636665650(0'584640/2233199/6+0)2&2+6:6546;-63+*404(4&90*8&78+57865696/864443&25729+.4,6-6-66:474/99758325763-:1-1-97//'2(,3:.662(378/9185977$14/0.)1/24)213(*61035&$.0453&(/#31,,1#'4/(411035*(.00%025/(/*5.0$,-1$.430%$/)5554161*/*3$11141-10622/-)$")#&+/1+00+55)1/.10/-15521/#.,55645*44*555,+,30320+/52255515,3.5((10.#*0&350163%/.'/+-#)%1*141,2(+/)444*040-6*54/1')-0$22*5151//50-0&*))3*2,,%#-4.020%,'/,1+(++.,#..!$-%0.5$!162200%230&.131(2*/)640*-)-..16 @rCer/139/1801_58_CCS ATGGGCTTTTTTCGCAACGGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCCCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTACAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCTTGGATAAACTGAAAGCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTATTATGTGACTATCATTGATGCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTGTTGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTTAAGGAAGTCAGCACTTACATTAAGAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGTGCTGGTTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTT + */;?$099=>9%>BBA:>>=6<:*<@4@?70?A<>=AB>@=<79<;=2BC<@A;/;??8?A@A<>B@2=B?@C@=B=?A<?BABCC?BB@:?C@@6>>479:=7795<=A>B?B<58=8;?6;;7C3BB=A;2;B9=44:-=7:=&:>?@=*8@5@A??=C?9>79??C=B;B>1B@5@?9@A/@AB?A?AA5=@AB>A>:@B6?CB>A4<=@C8;;;BB:B@9><=?@68B884C>A:>;7B@C?@;A?95:1.1;4'2=568,(4:=99:8*=??A;B:815B?>A;/:><;9;97@:CA>B=@B@4A;>=6:<&4=0=@1;B7@@:8:/7341;>@;4=95462?;8@@>C;A:?4<9=;;59AA=8>@8A?@>:=@B<:@*??9?>=A69?;8-8?=9>3>38;9;8=86>=33/==<>5;=69;;5;8;>=89=68=.4::92;6=>:>5<2?9>=:7=/08158905/2=96>8+482/*9::;<;:123<420702-==:3;=97*78/<>:6>=>?=;:>84:6?:1342<7>:>7?=<:19;<:0=5>8?=;56<=+;0>77>>8?;7=-;=>:>>3?=82=094:477=>=9>;;9-=9;38=7==5*204-<067'=::==78?=<-943>>?79:=1=8<6.=;?>9489==51>=;:=0;;9;?=?6318)28:461*=7516;;93?99864<8<5=;786(67;:14),3939/46;53=7=7;<<769<35+13.56-<4::8>:2:?6>9>9>;;6;77<:>=><<.6'089>;;>69;34>8:>9:+8455'15=;9:'::>>?>;;;;:4/77<8;A;>;9B>A=C=BA?A@5:3*,6377B>A=1<1A;C?=70AC=;@:CA@B;BCC=992;67:>BAC=<8;$<801<1>AA?B@C><;=?/8;*?3=@6:(>ACBA@=>A:=.@:A8=5<@@>=@CA?=BC=C4B9.:;,8@=B;CBCC??89;9&3;@=<6@7BC?9<6>;9=>?=;>98*:8<2;4<8:3789?==/<::$;893=:<:9?89;265301<;:87$6>>8>5;=9>;5832=867;44/=;=9;;=1=;9;928:265>7?;<31>6==;4:97<<;<7<93&06<:=>?<==>928<9<5--5447:545.53057937854604775651541:86777958;6:75:8130633855833*:7*8999,8;34755045.64978569;68415974863:33787635,5779+8:9836623016;77:73+1.5.48993074:591783582-23457122536253382)62822:55;88678566)/10/3$.45&.9-2(6+6439;457435&/:2.5455/14:674070612:94)%695-8383110668(55;:7406397;5590186333878#/6646986567%98875/::7:7:184330/3/5:4;;6660958:;9:9:67::.677-53185989983*5186*.6,39197731667456.89.879:72281596-776-:;86;589998-764, @rCer/140/44_3568_CCS ATGAGAGAACCACATAGTCCATAGAGGAGAGAATATCGGGAGGAGACAACCGAGACAGAGGCAAGACAGGATGAGAGCTGCAACCAATGCTGCTGACTTAGACCTAAAAAACCATGTATTATTAAATCCTGTCTTCAGGCCCCAAACTGTTCTGTTCAAACTATCTGACCACCTATCCAACAAACGGTCCCCTCAGGAACCATCATATAGGGGCTGAAACCTGACAACTTGGCATAGAACAAGTGCACTTTGATTCCAGAGAGCAGAAGTTTGAGAGTAAGAAACAAAATAAAGACCACCTAACAAAAACGAAACTCTGTATTCTCGCCCACTACATTACATGCTCCCCTTTGTGGATGTCAAAGAGACCAGAGGAAGTGGACCAGACTAGAGAGAATCTATCGTGGTCTTCTAAGGAAGATTAATCAGAAAATTTTAAATCACAGTTATCCTGTTCACCTAAAAAGCCAGAGTTAAAGCCTCTAAATTAGCCCCAGGAATGCTTAACAGAGGAACAGTAATCGAATCTTACAGATTGGAAAGTGGAGGAAGACCCTATCTGGGAATCAAAGCAATAGAAGCGAGTGCTCAAAGTGAAAACTCTAGGCAAAGAATCCCCGACAAATTTTTGAGGTCAGTTTTGTTACCAAAAGCACTTCTGGATCCCCGAAAGCTCTGAGCCGACGGCTCGATGAACTTTGTCGTCAGTGGCTAAAGCCAGAACCTCCACCAATAGAGCAAATTCTTGGAGCTGCTCGTGAACTGGAGCAGTTTGACTGATCCTGCCTGAGGAGCTCCAAAGGTCTGGGTGCGGGAGCACCATCCGGAGAGAGTGGGGAGGAGGCTGTTGAGCTGTAGTCGGAAAGATCTGGAACAAGGAGCTTATGAGTCCAGGGAACCAGGCTCTATGACCGATGAACATGGACATTTCTGAAGTATGCTCTCGTAGAGGTGAAATCCTGAAGGTCAAGCCAGGAACCAACAGACAAACCAGCTTCAAGCTATGGCTGACACAAGCTATAATTGAATCTTTTCGACCTCCACCAATTTATCGGAGAACAAAGATCGAGTGAAGATAGCCTGAGAACAGGAGTTGGTATTCAAAAGCAAGAAAATTCTTAAAAAGAAATGGAACATTTTGGCGGGATAGCAGACGTCACAAAGAGACGTATCTTTGGATTCTAAGTTACATAAGAGAAACTGGTAAACAAGACAGGCAGGCAGAAAAGCAGCAGGACATTCCAACTCGCAGAAGACGTCCACAGGTTCAAAGAATGTGGAAAACTCACTAAGAGTTCAGTACTCTTAGACCAAGAATCCACACTGGGGAGATAGTCCATAATGATGGTGAAGCAAATGTGGGAAGCCTCAAGCCGGAGTCAAGTCCTGAAATGAACATCGGCGGAGGCCACAGCTGGAGAGGAAACCCTTCAGTGAAGCGAGTGTGGACAGCCTTCTAGTGCTCAGCAAATGGGCTCCATCACTAACACAGAAGAATCCACACAGGGGAAAAACAATGAAATGCCAAAGTGTGTGAAAAGGCTTTTCCTTTCTCAGCTCATGCCTTGTTCAGGTTCATCAGAAGGAAAGCACACTGGGAGAAGCGCTAATTCATGCGTGAGTTGTGGACCAGCCTTCATTCAGAATGCAGGGCTTTCCAGCAATCTCCGAGTCACACTGGTGAGAAAACGCCTATCAGTGCAGTCTAGTGCAGTAAAATCTCTTAGAAGCGGACCCTTCTTAAAAACATCAGAAAATCACACGTGGAGAGAGCGAAACAATGAGTGTGGATGAGTTTGGAAAAGCCTTCAGTCATCATTGCAATCGTTATTAGCATTATTAGAATCTGTACCTGTTCCAACAGTAACTAGACTAATTCCTCTGATGGACCCTCAACCCCTATGGGGCCATTACTTGGAAAGTAAGATTTTCAAGTTGGCCTTATTCTGTTCATATATAAACTTATTTTTTGCATTGCAGTGATCCAATTGTCTACAAACCAGGTGTTGGTAGCTTCTGTGATGGATGACTGTGATTGTAGGGGGTTCTGGATGGCCCTCTTATTTCCCTATCCTTTGGTCCATTTCTAAATGATTTCACTTTAAAGGGACCAAATCTATATGAAATAAATTGTTATGGAGGGGCTGTTTTGAGGCTAATATCTCGAGCATATGAATAATTCTAAAAAGACCAGTATCTATTATAAGCTTTTTAAAAAAGATTGGCTAAGATCAAAAGGATATTCAGAGGTCAATCTTTTTCTGTACAGAGTGCGTAACGTTTAAAACACATAAGTGTTTTGGGAATAAGCAATTGTCCACTTATTCCCCAACAGGAAACATTGCTATGTCTCCCCTAGGAATGTGAATAGAATAGCTTCTTTAAGCAGCATTATTCCCATGGTATAAACAATACTCCGTAAGTTTTTAATGGTTTAAGGAAATCGTATGTCTTCGGAAGTAGGTGATTACCAGGCGTGGCTCACGCCTGTAATCCCACCACTACTTGGGAGGCCATAGGCCGGCGGATCACGAGAAATCAGGAGATCGAGACCAATCCTGCTAAACATGTGAAACCCACGTACTGTATAAAACACACACACACACACACACATCCTACACATCAACACCACAACACACCAACACAACAACACATTAGCCAGGCTGGGTGGCGGTGCCTGTAGTCCCAGCTACTACCAGAGCTATGGCAGGAATTGGGCGTGAACGCCGGGAGTGGACTGCAGTGAACTCAAGAACAGCGCCACTCACTCCACGTGGAGCGACAGAGCGAGACTCCATCTCAAAAAAAAATAGAAATCTAATGTCTCATATCATATCAAATTCTCATGCTGTGCATTACTGTATTTAAAGTTTTCCATTTTGTTACGAACATAATAAGATGATACTTTAAAAAATCTCTCTTCTTACACAAGTACCTCTTTAATTCAAATGCCTTTTAATGTCCGCATATTATCTTTTTGGGGGTTGTCAGCAACTTTGAGTGCCATTGCAGGCAGCATCATGTGAAGTAGTTTATAAAAAAAGAAGTCTGATATTTTCTTGGGCACTTGCTGCTTACTAGGTAGAGACCAGCATGCTCAGACATTTATTGTTAGGGATTAAAGTTAATGCTCTGGCACCAGAAAGCTGTCAAAGATTTTCCTACGCCCATTTCGTGAGTCTGTGGGACTTAGGCAACTTATCTACATGCTCCTATCTAATAGTCCCATCTGTAAAAACAGAGGATGACATCGTACCTTCTCATAGGGTAAATAAGATTAAATAAATAACAAACTTGTACTTAAAAAATGTAGCTCTCAATTAATGTAACCATTATGATTAACAATAAGAAATAATTACCATTTAACAAACTATAGGAGAATTCATTATAAGCTAATCATGTTTAAAATTAGGATATTGAAATGCCTCTGCTAGACATTGTGTACTACTCCCTTTTCTTCCATAGTCTAAAACCTAAATGCAAGTAATATTTCAAAAGAGTGATGAAATAATACAGTTGAGTCC + .,)#-.-).,/--.%#-"%++'#(')))$(($&"&*-++*,-(+$.,##&-.(/*//-//,/%,.),/-,*.././.-.-.*#&-(+"-..,./.#-,-",),#-$$%$$-,/*/$"..."-$#+%"*/,//.-$.).()))/+%*.(+%-/-"-&,'#)./-,--('-/.+/-+/%%*./-%/,#..'**-//"-.%.#-#+/.--#*,*+,/.%,%/,//../-#.-%*('./#--#.)&...#--,&'/..&)-//&/.-/./+//,+%-.-$/.+--+&,.,-))*))//-.#,(-").-,#(*//.&+'..*+,.//#./,.(-/.+"&.*-/+/./".-'*)-.*+&-'#/)...*+/,.+/,/.#'-.+///-./"//-/...%,,..+/"/#+-(/.%-+*-/.+*&-,),"'%.+/.//%+*$(-+*,-*.//,-/.-,/%+.)"--./%..,$+%./,..//+.#+$./+.//#,+/-/*.*++//.-+////(-#...//..%..///)"///%.//-.&///,..-.+&..%,-+.-+*/&*"//././,+-($/&+#.-$),%$*$)(+))&,(+-.&(-.--*)+$'$&+--**%%,-%,"%$%,-'-%(#'$(%(+',*"--.,+%..-+,+/"&*./"/.-/./.-"-'&#-&,*..."..&)-*-.(..+-.&--"-),%-+-(-..*.+,.-*--,&..+///*%$&$(-.&,$/#.././,*/$..(,-,'-+#-.//,.-"#//,-/-///.+.'/.+"//*-&&,"-..,+.,./*,"$-.+%//,-././-,-..//#*/.,-$#/.,.+./*+*+.+,./,../-&-#//*/-./'-/$)&.-./-/.-)//+.-*///.//*/.-#.&)*-,+/,///-./.-/#/.-/#///*.///.+../+,/../+..#"//./..,+#&,--'.(+**/&"%-,&$..-+/.%-.#&'/,/*..."./"-#-////-).%-//+//.+$/+///-)#..,#/+*/'.."*..*)***#+//,/.-/*//+*#&..*-/*.."+/,/.#/".//*/./.'"(-.*.$)///*,/-+,..-*.'$'**../"*/,%)#$".,--($*+/-+//).+/-//,).&(/),.///.-///.),.#*+&/*.////.(///*-,-/,/*/%/..#.//*"#../)$../#'.)'.&+.///--&//.+,+/-**.///*-/.,/**"-+.)"-+".///*//..,#,/./+..."/,)/.*/*//.#-'*/-/$/.$-."//(//+.-""/--,.*&,*)//&./+/...//*+,+..-#."$-&//&.,-&/.%.,*###,*//,-,-,+//+/),$+),/..'/'.*/&"+//.+*,//+/././*,/-+.%,+../."...-/./#.+*,'++./..//+#,&".&.(&-'..*/-+.--.".#/.-#///.,+/-"#,,"#."..//.%/////,+//+/.%-)/-..,*%*)#((/.+,./-&///(),*.,/.&/.*-+&//*.#*%.).-%--".%-..'/&-+/.&++/..(.+"-(--*,+(..,%,$%.-/./,,'.-+/,./.#($-#/&/./*#%..++.-.-*-#.-&/,....,-./+).$//-*+-.(.,.../#,+/.(.+&/../-//..//-,$,((/-"+../&////)///.-#../*//-.,(*'#,.,**-+*(-++--(+.-&.,.-+(*//,././+%%.-//..(#/--+-.,-++&+(,#$#,---../##/../+-+---,-*/.+/,&//-+.//.&.),.*///"(-.../*/**-"+.+/*/--+#%.#/-,-,&,$-%-.%*-.-././-*/)/,#+,//"..-%)+-./)/*+),.+/,+-+,*/"/%/-*+.-+-//&./-,'(,/+//#..)-"',/.)./*-//(////%,$/.%//.*(*+..-/..+/////'#,/$,+.///.//-+.)/.#-,&+,../#(+%+..-//#---&././/,/./..//&,)*-'+(..--#.*+*".*+,/.-,.*$(-)/,#.'-.).*//.+-//-%././',),"..*.-+/--,-(*''+.'..././*-$.-*/-*/.///(,.)(,,./-,+)-)-+$."*+,-#,-$'.)./-"/+&//+-+*/.(,%(,..+./(./,..,'..+)+-,+('&'())))&----+,.()..-)&+#)(,&/././//.*...&-#//.+,&./......-+,.&)-"$#..+)*+&&//+//.+/."/-,*-(*-*++*)-"((.-..*,-$$#.-(''*.%.-/.,%*"+)..(.,*/)&,.)**.+.-.+/.//.+/*//%///*/,/./&.,/..////.//#/+%//++-'..*'##+##,&"&-&.#/--,,*/*-/..(*)-"-.,+//.#////,.*"/,,#$#...&,//.//*#//,../.-/.////*//-/+/-+,..,&(./##.-,,,/.*,/.#//))//*....-.)../.&*).*-.#.////,/.+,/$+.%/.*/,,+)///+./-+/,,"../-$/,,.(/***/.&-../-/.+*-+///--,.%##!$&-.-".,"/.,,.-''-*,*#.$,-,/*/.-#////)/*.-.+/&/&+,--'+/+*)-)//.,/#-*-//.///.."+/.$//../".,///.+*/#+-*//..&,+#,/--,-),--&.-///-&/+/-"/)//%-*#./.+/&.$/.,#+/////+,#.///././'/./-*-.+//--//,,''+,+)/*.-,+///.%",.+*///&$./../-/,+/&--,/(-.../#"//-//..//./,/$+//.,*(*-..",,,.(/,",,"/.+/,,,#*,////.--"'.%)$...)-,$,//+."&(/*,...+$&.(+.+/.//*'&#.&-+,)/,"."/,-),//+,//-/.%'+-+'%'',.-..+/.+-//).+/...#./..*(./-///..././&&/+//)//-*-'/-&,,*&.'*//-/+-...."+'--,,-+///.,../-/--*-%,-.$#,-,*-/.+...$//..)&%)-,,.-$/-./---$).-+/-&/&*/)-.//.+.(,#%#&&--#-$//+,-#/,*+"&..","*)./.,.#-/./.$#///*,,//+-//*.*/.-//&/.,#(/---*,./../%/)&&'&&///.//#)*+)/-//..-/////,.//-/,.-+.(./..--//+$//,.//.*,+/*-+,/.!/-)/..,-//-./,-,,).-/.*./.../*-,,+).+*#.."/-.////..+//%-,-/$)*//+.#//-///,/*/.-+/'*///&-..*,/.#"-//"%**"+'&/////.'%,-*.///../-/#./-+//#-#..,)/."////#.,/'...'%(#&$*.+*/."-+.-//-./"--*/,-/-+/.$/%,.#%/./.+,,,,)..+.%..",*%//,/"-$..-'---#+. @rCer/141/25_1777_CCS ATGGGGGCCGTCAGAGCCGCCATCTTGTGGAGCGAAACCAACGCCTGGCTCGAAGCAGCAGCTTCTGAGGTGTCCCTGGCCAGTGTCCTTCCACCTGTCCACAATATGGGGAACATCTTCGCCAACCTCTTCAAGGGCCTTTTTGGCAAAAAAGAAATGCGCATCCTCATGGTGGGCCTGGATGCTGCGGGGAAGACCACGATCCTGTACAAGCTTAAGCTGGGTGAGATCGTGACCACCATTCCCACCATAGGCTTCAACGTGGAAACCGTGGAGTACAAGAACATCAGCTTCACTGTGTGGGATGTGGGTGGCCAGGACAAGATCCGGCCCCTGTGGCGCCACTACTTCCAGAACACACAAGGCTTGATCTTCGTGGTGGACAGCAATGACAGAGAGCGCGTGAACGAGGCCCGTGAGGAGCTCATGAGAATGCTGGCCGAGGACGAGCTCCGGGATGCTGTCCTCCTGGTGTTCGCCAACAAGCAGGACCTCCCCAACGCCATGAATGCAGCTGAGATCACAGACAAGCTGGGGCTGCACTCCCTACGCCACAGGAACTGGTACATTCAGGCCACCTGCGCCACCAGCGGTGACGGGCTCTATGAAGGACTGGACTGGCTGTCCAATCAGCTCCGGAACCAGAAGTGAATGCGACCCCCTCCCTCTCACTCCTCTTGCCCTCTGCTTTACTCTCATGTGGCAAACGTGCGGCTCGTGGTGTGAGTGCCAGAAGCTGCCTCCGTGGTTTGGTCACCGTGTGCATCGCACCGTGCTGTAAATGTGGCAGACGCAGCCTGCGGCCAGGCTTTTTATTTAATGTAAATAGTTTTTGTTTCCAATGAGGCAGTTTCTGGTACTCCTATGCAATATTACTCAGCTTTTTTTATTGTAAAAAGAAAAATCAACTCACTGTTCAGTGCTGAGAGGTGATGTAGGCCCATGGGCACCTGGCCTCCAGGAGTCGCTGTGTTGGGAGAGCCGGGCATGCCCTTGGCTTTAGAGCTGTGTTGAAATCCATTTTGGTGGTTGGTTTTTAACCCAAACTCAGTGCATTTTTTAAAATAGTTAAGAATCCAAGTCAAGAACACTTGAACACACAGAAGGGAGACCCCGCCTAGCATAGATTTGCAGTTATGGCCTGGATGCCGGTCACCAGCCCAGCTGTTCCCCTCAGGAACATGTGGTGGCGCAGAAGACCGCGATCAATTCTGCATGGTCATAGTAGAGATCCCCGCAACTCGCTTGTACTTGGGTCACCCTGCATTCCATAGCCATGTGCTTGTCCCTGTGCTCCCATGGTTCCCAGGGGCCAGGCTGGGAGCCCACAGCCACCCCACTCTCCCGCAGGCCGCCCCACCCACCTTCAGGCAGCCTATGGGACACAGGGCCCCATCTGTCCCTCGGTCACCGTGTGGCCAGAGTGGGTCCGTCGTCCCCAACCCTCGTGCTCGCTCAGACACTTTGGCAGGATGTCTGGGCCTCACCAGCAGGAGCGCGTGCAAGCCGGGCAGGCGGTCCACCTAGACCCACAGCCCCTTGGGAGCACCCCACCTCTGTGTGTGATGTAGCTTTCTCTCCCTCAGCCTGCAAGGGTCCGATTTGCCATCGAAAAAGACAACCTCTACTTTTTTCTTTTGTATTTTGATAAACACTGAAGAAGCTGGAGCTGTTAAATTTATCTTGGGGAAACCTCAGAACTGGTCTATTTGGTGTCGTGGAACCTCTTACTGCTTTCAATACACGATTAGT + IH(KKKF?KGJJKKJJEKKFKIIFFJKK(IFGJI$IDIK;KJJ8KK>KI?HJ8JKH8HGGGIHKKHJJAJ;DD*JKGHJ@IKJHJJGKIJFKKDKKKG;>?>%D;GG&JB?A@IH>?>FB@CEGH:B>@=II7H/FKCG)KGK62KH%KKJJI:8DHFJKJJIJEK@IG?GIH-HH;JJGKBIKKJKK/KKK2K?FCKJKFF:=JEKJJKFKIHAKHKJJJAKJDHGHFDFHJJD8I9DGB=G%@C<=IAG=;JJ5GF6KJHKKKJJICJGGAD0JKFFBG?KIC?KH1EHHIFJKGI3@@JKIJ4FAG&GIIJHHJHJKIBJFEHKC=FFK;KKKEEKK@KICJKIJKK;JG@KJHKJJ6GKJIGKKIJ(JJJGAKJKKEIKKJIGK>KJKKKKK@JKJJ2KKKKKKCHGKIBIHFEK0KKKK5KKJDIKGGKHKKJKKKKK@KJKK;IKI:K@KKHKKKEK>KKKKHKKKKKKGKK?KKKKKJKIKJAIKK>KKJDKKBKKKJKKJK;KHK,FKKKHK@KKJKKKKKJKKIJ:)@KKKK>KKKKKKIK@KKIKKJKFKKKKJKKGKKKK?KKHKIJIGJIK:K:KKKB@(JGKJ@KGKKKIIKG=5KKJKKKHKKKKKDKKKKKKKDK8IKKKDKKKEKKJJKKKHK&KKKKKKIKEKKGKH/FKKKHJGK3JKIKKIKIKKAKKKK,KEJ7K=KHKKKKKKKKKJH>KKJJIKKJKKBKKKK@KKKK;KKKKKKKKKJKKIKJJKIKBKKJCAKKIAKKIKKJAKKKAKEKKKKJK?KKKKKKK.KK4KJKKBKDJKFK?K:KKGKKJKKHK8KKK/KK4KKKHKJKGKKKKK=KJKKHKKKJIKK@K>K:K:C8EJIGHK-KKKHKKKKKKKKDKKKK @rCer/142/25_2693_CCS ATGGGGGCAGCCCGCGCCTCCTCGGCCCGCGGGCGCTCTCCCTCGGCTGCGGAGCCCCAGACCCCGGCCACACTCGGTTCGACAACCCCAGACCCCCGCCAGCTGCCGCGAGTCTCCGCTGCTGGAATCTTGTTAGCGGCTGGCTTTTTGGGGGTTCTGGTTTCCCGACATTTTTGTTTCCACCCAGGAGAGGATATCGTGATTTTCCCCCTTGAGCCCAGCTCTGCTCTCTGGGGGGGTGGGGGGCGCTCCGAGCCGGGAGCCGTGCCAGCCGAGTCGTGCGGGCTGTGGCAGGGAAGGGCCACCATGGATGTACTCGAGCGCAGAGGAGAGAGCCGCCCTCGAGCGGAGCAAGGCGATTGAGAAACCTCAAAGAGGATGGCATCAGCGCCGCCAAAGACGTGAAATTACTCCTGCTGGGGCTGGGAATCAGGAAAAGCACCATTGTGAAGCAGATGAAGATCATCCATGGAAGAGGCTCTCCGGAGAGACGTGAACAGTACAAGCCTGTTGTCTACAGCAACACCATCCAGTCCCTGGCAGCCATCGTCCGGGCCATGGACACTTTGGGCATCGAATATGGTGATAAGGAGAGAAAGGCTGACGCCAAGATGTGTGCGACGTGGTGAGTCGGATGGAAAGACACCGAGCCCTCTCTGCAGAGCGCTTTCGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCAACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTAACTGGACAGCCTGGATCGATTGGGGCCGCGACTACCAGCCCACCGAGCAGGACATCCTCCGAACCAGGGTCAAAACCACTGGCATCGTAGAAACGCACTTCACATTCAAGAACCTCCACTTCAGGCGTTTGACGTCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCGTGTCGCGCTCAGCGGCTAGACCAGGTGCCCACGAAGACGAAACCACGAACCGCATGCACGAGTCTCTCTGCTCTTCGACTCCATCTGTAACAACAAGTTCTTCATCGATACCTCCATCATTCTCTTCCTCAACAAGAAAGATCTATTTGGCGAGAAGATCAAGAAGTCGCCTTTGACCATCTGCTTTCCTGAATACACAGGCCCCAATACCTATGAAGATGCAGCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATATTGTTCACATGACTTGTGCCACAGACACGAATAATATCCAGGTGGTGTTCGACGCCGTCACCGACATCATCATTGCCAACAACCTCCGGGGCTGCGGCTTGTACTGACCTCTTGTCCTGTATAGCAACCTATTTGACTGCTTCATGGACTCTTTGCTGTTGACGTTGATCTCCTGGTAGCATGACCTTTTGGCCTTGTAAGACACACAGCCTTTCTGTATCAAGCCCTGTCTAACCTACGACCCCAGAGTGACTGACGGCTGTGTATTCTGTAGAATGCTGTAGAATCCGGTTTTAGTTGAGTCTTCACATTTAGAATTGAAAGGAAAAAAGAACATTTCTCATGTGCTTTGTAGCTTAAAAAAAAAAAAAGGAAAACTCACCATTTCATCCATATTTCTTTCTTTTTCTTGCAAAACAAACATACCGTCTGCACCCACGCCGGCCCCGTCCACCTCGCGGCGCAGCCCTGGCGCTCCTGCTGGGGGGCAGGCCCATCTGCCGCCTGGGGTCCCGGTGCGGTGCACCGATCCGAGGAGTGTGCTCAGGCCGGGCTTCCAGAAGGCCACAGGCCCCTGCAAACCCTGCTGCCTGCCGGCCGCCCAGACACCACAGACGCCACCTCGCGCCCTAAGCCACTCCCGCCACATGCTTACTCCAGGTTGTATAGAAAAAGCACAGCTCTCACTGGCCAGTAGCTGCCAAAAGAACACCCATCGTATATGGAAATCCAGCCCCATAGAAAACAATCTGCCCACCAACCCCCTTCTACAGATAGCCTTGTGGGGTTTTGGGTCTTTTTTTTTTTTTTGTCCTGCTGAGTACTATGTATTACACCCCCAATCCAAGATCAGTTTTCTAGTCTTTGGGAAACGGGTTGTGGTTTTTTTTCCTTGCTGTGTTGGATTTCCGGTCCCGGCTGATACCCCCCTTCGTGTGTGCGCCCCTCCCACCTCTGCCTTTGTTTCGGTGCCCTGTGTCCGCCTCTCATGTGGGGATGTTTGTGCTGCAGACAAAAAGAACAAAAAAAATTTTTAAATACCACAAGATGGAAAAAAAAAACACAAAAAAATTAAAAAGATGGAATGTAGTGTTTACATTAAAGCCACCGTTTTCATGACCAATCCTATGTCATTTCTACTTTGACTAATATCCAAACCCCAAACCTCTTCACGGTTTCACTTTTAAGACTTAATCTTTGCTGAAGAAGACCAGTCACAGCCATTTCAATAAAGAGGAGGCAAAAGACAAAACACACAAAAAATAAAAATAAAAAAAAAAAGGAAAAAAGAAAAAAAAGCCCACGGGTCTTTGTAAGCCTTTCTATTCCCAATCGGTGAGGTTTCTGTGATATCTTACACACGCCAGTCTACTTCTCTGACTAATGGAAATTCCTGTGTAGCTCAATAAAGAGAATGTTTGTC + ''%')(++,)(*)**'+-&&*-,,-%**+,%,(+&$"&''**))'-%((+-.-,(--,#'+(+*(%**+,,(+(($()--*((##%%-+&'$$)++)#%&'))--(-'+-*+$,)$*)((+$%))&)(,)+#%'()+,-+('+)#,,*&"%))&$)*&&*%+-*-.-,,)%*'&%+&(*#$'&--,(*'$+&*''((+-)+)(,*'#,,,,,-+)('-+%%+,'''((-(-,%*&$(++)),,*,-*)&%(-+%&*)$('&((,,)+),,-),+)*---)),$,*()*-,,,(%+,(($-+&**&+%$%)*--,)-)&$----,(),,--,,-,-)--)-'#*,*--)-),-)+(-,()*-)((%-*'-))#)&(-(*,)(.-)),'-,,(,')-&*(,--+'*'(&')*,*,-'+-,%(,,+,%*#('(,-+*$+))(--(-*,.--,),,-,)-+'%)&)'((+'++)#(+(,*"'$#*+'&))*)%+1/)(/),-11-+-*0*&-+.%+$'$,0-++1),01+1*&(&-/,+1,--.1+0*10,',-*-&)-02/1-,%'%+#()%*/0.--,-2(,(*1,10&.-02001.%.+&-+-+)0,,1'/+,-((0)+*-111*$+)',-.0/2*,',#*+.0/-/'(-%'--%+,.'*-0-10'$,),+"%,,/-++**,0,+*0.+-,0,,/+-'/)/,,%(/*/-01/---0,.2+2,1*&+++2/)*1-.0.,'&-$-,.,+&.+%'*%/*)*,+$"(+),,).-,-0%,-,+%-.,%+,))/,#*+&,/-)/-),11121,--0+0)-0+,,002,12+,*',))-#++*#()(%%-0)((,&--,.*-+*..120'0*$.-'+/'0,3('.11$/,00//$,450*0304-.//3.1.4650)03142.53523$3,1165.2632620.4545,21//464,/2/65/1+)//12(*0/)/2.3-33.3.43,.%*&+(&#).+$')1)+..2+'&,/0.+/-'3*+5+*-/4)0+,..+++)/%,/0-.30651)*2.04/21,..)3(--4&+.(+)*)*-./5*(%,03/3,$-344*544/0,42'3-,65640235+33'1452.%0/2*/0,5*3+05),1%-441*0.11292'.28571'5/'-/(.-316940988799/4.3:9044303.,*+322234143552)748(789+548:.9:::56::724-.6493.:9,,85(/34+(2$1+/)+.4366670(-81642342&2*-29:-5&-895:1,23--697.4,/6644(.:5-..487.75.547;8;449060+.&.2542.3+/4'/2..)/1*163/&-,/.2,1'*%.23+/15/5055369258+7.+22561'4%3687559557:7&13528615-/83-64.55457$32465/7(76('1,144249761:-33764,206054%9856-,80;6;665/4,20745./0064.421%.-/1,+.'$112+'2421752,734:7812987)386383;9/1/.+41114./7/242%866?932&<===8,&7<;1=968/+&'-*8(::;<8:8)'#87769:9;;9:7.2)9:977343810/:542/6463-7:6,464)5268,+275/66:3$/04474'81-55223.95(,313*6%753/$#../6.88706156152:81077331.:514&$66874-'$8$)4229356;:+821:::55:9,41/7445942/443'2980'380423/56,3497;%724'7-.3/49)7-6:86&2&852268/97/9:136-816..17&.114/472*344475949947693281752&+9915:3082-&,977*)-.-412/88-,16(*.'10.2143'6450/656:993*'3639871:*212471238(7352,2.79;;:41880%1312)640///5'4424446,7778'463.-095428&2-9:2&%523,898955215)2--07:3#/--%1-+3+455445544240382-6-5/.8,14/-/.(+,+&3-1'/77::/4(/5-739744*&68)&,*/+5&226;;0579*83(1*(25$7632441,0(,28/144.0'7+/3120,22,80/4359592%/05642529+74619691:02.+9410296-.*4$214.56.*3,989713856140&%3325-(,%%46543-,4761'3/7:0&19%74/22250#-)01..*&,42(&/64429683:-5.'/$677777/.--+3&55442,+7&./,/03-/7&6%61'5.3-22184)7)441*4+'35%0435+4776:.3326'1',514(781545/3992/,-794465*88,5.4+331713&,-2404,472--$0/1-7,47.7+00928:::.-273%1+74:14.4022.11/$-/1)30&7:2/.54366&998477&88.77913++952/1%22///&741588777,+0&36576,%03.0488922927*6446(253575.7;*37/).-87;;3:5542440-4(7621585-4675&-+-4868)2:49-)36-495/4-4270/7112).1#)*/.211521021)0.'14255%0/4*2233% @rCer/145/1181_46_CCS GTTGCATTCAAGAAGACTTTCTCTTACGCTGGGTTTGAAATGCAACCCAAAAAGTACCACAATCCTAAGATCGCCCTTTTGAATGTCGAGCTCGAGTTGAAAGCTGAGAAGGACAATGCTGAGATAAGAGTCCACACAGTTGAGGATTATCAGGCAATTGTTGATGCTGAGTGGAACATTCTCTATGACAAGTTAGAGAAGATCCATCATTCTGGAGGCCAAAGTTGTCTTGTCCAAACTCCCATTGGGGATGTGGCCACCAGTACTTTGCTGACAGGGACATGTTCTGTGCTGGCCGAGTACCTGAGGAGGATCTGAAGAGGACAATGATGGCGTGTGGAGGCTCAATCCAGACCAGTGTGAATGCTCTGTCAGCAGATGTGCTGGGTCGATGTCAGGTGTTTGAAGAGACCCAGATTGGAGGCGAAGAGGTACAATTTTTTTACTGGCTGCCCAAGGCCAAGACATGTACCTTCATCCTCCGTGGCGGTGCCGAGCAGTTTATGGAGGAGACAGAGCGGTCCCTGCATGATGCCATCATGATCGTCAGGAGGGCCATCAAGAATGATTCAGTGGTGGCTGGTGGCGGGGCCATTGAGATGGAGCTCTCCAAGTACCTGCGGGATTACTCAAGGACTATTCCAGGAAAACAGCAGCTGTTGATTGGGGCGTATGCCAAGGCCTTGGAGATTATCCCACGCCAGCTGTGTGACAATGCTGGCTTTGATGCCACAAACATTCTCAACAAACGCGGGCTCGGCATGCCCAGGGGGGCACGTGGTATGGGGTGGACATCAACAACGAGGACATTGCTGACAACTTTGAGGCCTTCGTGTGGGAGCCAGCTATGGTGCGGATCAATGCGTTGACAGCAGCCTCTGAGGCTGCGTGCCTGATCGTGTCTGTAGATGAAACCATCAAGAACCCCCGCTCAACTGTGGATGCTCCCCCAGCAGCAGGCCGGGGCCGTGGTCGTGGCCGCCCGCACTGAGAGGCACCCCACCTGTCACATGACTGGCTGGCTGCTGGGTGCACCTACTCTCCTTGGCTTGGTTACTTCATTTTACAAGGAAGGGGTAGTAATTGGCCCACTCTCTTCTCATTGGGAGGCTATTTAAATAAAATGTAAGACTTC 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'/-30)31851/-).)444(-0/3,31,4531+68*06:.232/1514033-')52-.418326425(,+30.-6,625&390,8,7.5/620+1,//4'--4,3.0,&&7.372%3626353.2*-)15*648412735,335$10-/*5.1-012+-0+-763/8224477)00113'5,.4.3.,0/3,.'*)63/+53-90-56152-1$(+#$4/-.(+7975/52.2626.+(&*&%--&,4.*1$//4)('$0%/*-1010$4-534430-()83456.455(./+-/-0.152.-.6849054130,(-+#$%*'*-6.0+12-.-(/.00)-,-/0,-+4+2*136604(./2,446./624*42(..%(5*17/3/2(556'03/--*%06+1+'2/*+,-4334+3.)6+04-.%"#$&$'-&+***30+.2%/(/.+.0)/0$2$10(/),%++(#*/)117.53(408365065.5/2&21),()*()/*3+6(--'.4*02800.4/(34/)/*+/10122,0'*2784*6%(/16..2/$.)**,-&+11+02-0-44752/8,447,*'%)626&./)9)060-(235+833,2/,&)-1((6/,54.14*/3*4424-4/633&&,57%'41(5,46/.*+*-$+1.*021&.'+/0,7,+*2-6+1+829760,0+)/*0159&/5,2603=43.2(51/3<8873.-4:451,(12**&.-796996;7'#,4(4)36580,,4252,10---2&::26./).222'#'9:.41.764*7703*84+82..)607;65677:=24-<371219::;4=943,92312-1*8146-51%85=3,:80;374:7:9769=:098883;573:=845003521/07:74;23376872640(68/42'/89<354<93016;151,684030.7);70)888;2946/,)+'*.8689298.624;96:8-+1//4/5-8755;/091<8,28*29:7:3=7578.;-<8743*0/0+54450119786131/559*2024466).23,10225-//-$8*0*.389:3.)05&/40.534'(./-0+69)%1+55:/7.7=25<:707770095-3'/ @rCer/146/1083_62_CCS CTCGCCAGTTTTGCTAAGTCTTGATTGCCACATGTGATAGACAGTTCTGTGATGGAGCAAAATCCTTGAGAAGTGAGCCAGCGCTAGTTCTTCAAAAGATGAAGACAAGCGCAGCAGTTTCAACAGAGGAACCAAGGAATTAATCTTCATCATCTTCTAGAAGAAGAAGTGAATCAGCAACTGATCTTATTGAATTCCTAACCCAGGACATAACCCCTTTGGTGTCTAAGGCGGCATATTTTCTACCGTCAGCATCAACTTAAATGGTTAGGTCGTCCTCACAGCATGACCCAGTTGTCACCTGCAGACAGCCCTGGGGGGACTTTGAGTGACTTGCACCTTATCCCAGCAGGCTCCCAACTGTCTCAGGCAATGGAAGTGGATGGAGCTGAATGACTCTAGCAAGCAAGGCTATTCCCAGGAAACCAAACGCCTGAAGCGGACACCAGCTCCAGACTCTCTAGGCCTAGAAATGGAGCACAGGTTCATTGATCAAATATTGTCCACCTGTCGGAACGTGGAGCAAGCCAGGTTTGCCAGTGCATACAGGAAATGGCTGGTTACTTTGAGTCAATGAAAGAGGTGAATTAGTCCTACAAGGTTCCCCTTTTAGTGCAATATTGCTTTCTTTTATTATTTACATAGTTGGCATGAACTATTTACTATTATTGGCTAACCATATGTTCTTCATCTTTAGGTTGAAAGTCCATAGTAAATCTTTCATTTATTTTATTTTGTTAATAACTGGCATTCCTGTGGGGATAAAATAGTTGTATAGTTCCTTCGTGCTAAACAACGTGTCTTAAATTTTCTGTTGAAACTTCTCACCCTTTGTATTTCTGTAAGTGGGGCTTCTCATTTGGTTTTTCCTGATTGGTTCACATACACACCTCTACCCACCTCAGTCCAATTGCTGCATAGGCAAATTATTTTAAAAATTAAAAATTTAAGGCAGGCGGAGGATCTCCTGAGCCCAGGACTTTGAGACCAACCTGGGCACACAGCAAGACCCCATCTCTAC + #"$%%%$%%$%$%$$"""$$$"$$#"$%#"""#$"#$#$#$%()(('#%%%"'&&##%&(($()&$$&%((%$%$()&((&())'%$%(()&##&($(&%&)((($$$'$&"#$'%(%%#''#'()&$#)()))((('$)&)('&$%((&(((((%(''('%()'$)''%(&'#$&$'#"'%$$''&('&$($$)%%#''#%$%(%'$$%$$$%''%'%#(',-,&%)',())+)'(*+,+%+-+-'"((#%)(++'#)('')'),'$$',,%'#$1-.-*&/))&-,111+.--'1101+**,10+.,,02,/%'(*/-'001/,..+$*,+0+)'(/,0)0,(.*)+-'*,+%,0(*0+/,0../(00.0-02,-)112.'*..0%01,,,10,-)+'*011,110*0,10+/)+-&0/'-,)++-.+-/1-0.1*'+%+---++-,102.-1,/.-110,',-*1./+,&/1,/,0100.'.*-1..*,*0-,*'&$++&%*,-112..212.,1,0-/'.0+,20-0,//+/0+).*',+)+.-21021,1,,/0-0,++00(01.011-*,.1----+11.)/.,101*&/*/+101(*-/(*)*&,,10,*$,1/*%,---+0/0(+0)*11,/*,+000**%-,-.)-.0-12*1,*++-1.-)(--1,/1+')0+'#)('/+,+)+&/...&-,)(**1-+**00,.)-./0'/+-($+//((.//0&01)+++,).100'+0+.0-0,/-0+++-,*&%)',-+'*-+..+.+/&,10(+'+,*-0)0*.-+,1-,(*/21.+&020,)/'/+'--/).1(.1)..*.'('(*(*+,((,0$)2-1,()*+(1,*+0/%.11,/+*.)2/0)$#$)*,,('##$&,..,(-*)-,-,.)&$-)((('++,*&''-,)-+'&)+$')-((.*+,(##*"$-,-)"#)&"&),(',)---*,+----),-))'),$,---$&-(--+,-&'#'*('(+(#"&-,-(*%$(*(,+ @rCer/147/24_2166_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + KKDKKKJIKKKKKIKEKKHKKKKKKKKKIIIKKJKKEKKKKKKJKIKKKKKKJKKHKKKKDKKKKKKKCGJFKKJDKKHKGJKKKKKKIKKKKKJJJKKKKKKKJKKKKKKKKKCK>KJK?KKKHKDKCHKKJ6IKK=KIKJCKKKKJKK=KKFKJKKHGKKKGKKJKKEKKKKKK8KKCKKKKJKGKKKKBFIKK)KKKJJKJKKK2KK0KK(KKKFJJJKKK5KKHKKHKKKI@DCJKKJKKK+KKJFGKKAKCKKKCK@KKJKJKKK(KJHKKHIKJKKJKKKKKKKKKKKKKK>C;AAKKKHKEKKKK9K?KKJ;KECKKKKJKK;KEFJ8KKKFKKIJKKKDKKJKKKIK:KKKKIKKIK,KKCJKKKKJJDKKKKKKIKKKKKKFHKEKKHIKKJJKKJKKKJKKKJJKIKHJK@KKFJKKJKFKKKHKKKKKJKIKGKIKKKK>KKKJKK9KKKKKKKKKIKKJIKKJKK7KKKJKKKJKKKBKGHKKKKHKCFIKKK:KKKIJFJIIKKGIKJJIKIKKKJKGIKI9KKHJKJHKKKAKBKKKKJIKKKKJIKKKKKJIKKHIKHKKHKECKKKHI9EJH>KH9CFJIDKJKJC)IKKKKKIKFKKKKKJK:KKI&HIIHKKKKKKKKJKKDKIKKJKKHKKKKD=JKKFIHKKJKKI6KKKKGKKJKKKAKKFK:KHJKJKKKKJJKIKJKKBKKI>IKKIHKKKKKK9K%ICGKHKKKKKKDKJDJ=KK9HGGF5KKKIK4KHJJKKEKEKKJKGIKKIKFIKG=KKKKK2KKKIKKKKKGKKJKD7JKJKBKKK?KEKKKK@KJKKKKKKK:KKJCKKDEKKKKKKBIKKJKKKKJKJKIKKJKJI;IKJJIKKIKKCDGK6KKKKKKKKJKKEKK=IKIKDJKKKKJGEKKKEKIKKHHK>KJGKKIJKKKJKHHI;KIKKHKKCJK9KKJKKJJKKKIKFK(KKKKJFCFJGJKJIKIKIGJIKICKJKKJCJAJ?HAKJKIKKKKKKJKJKKIKHKIIJGDK5GHKIHJJKI6JH92JJAHIJKKKKKKKEKKJFA-HJKK.KKKGKKKKIAKKG6JCHJDKJKEKHK/IKKKK6KKKKIKH@HKKJKJHIKKJ(KKKKJBKGJJ?KJJKKKKKKKJGKKKIKIKKKJKK72'KKJKKJHJGKI5I3GFHKKKIKKJHK5IIIKGKKK@KKBKJJJ9KKK>KFKJJHIGFGGJKKFKHKKKJJFGK1KKKKIKJJJKIJJ;KKJKIKGKKK=KK:KKKD@2KHKHJJKBKKFKKKKEIJ6KKKKKDKKKIEKKKKKHKIKKKKKJKKKJKKJHJGKFKDKHKKJKBKKKKKK7IJKKGKHKKKKHIKGKJKGKJIKJKHKKKJI@JKJKGKJJKIKIIK@KKKKIHGJKKKHBKKKEJKKKIHKIKKHBKKJKHK=@KKJ'I @rCer/150/1967_55_CCS ATGGGGGGGATACATCCTGGAAGGTTCGTGTGGGGCTGGGTCCCGGAGTGGGAGACGTGGAGTGCAGTTTGGAGACCCTGACACACCCACCTTCTCACCTGGGCTCTGCATATCCCCCAGCCTTGAGGGAAGATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCAGAGGAGCCCGCCAACGAGCTGCCCATGAATGAGATTGAGGCGTGGAAGGCTGCGGAAAAGAAAGCCCGCTGGGTCCTGCTGGTCCTCATTCTGGCGGTTGTGGGCTTCGGAGCCCTGATGACTCAGCTGTTTCTATGGGAATACGGCGACTTGCATCTCTTTGGACCCAACCAGCGCCCAGCCCCCTGCTATGACCCTTGCGAAAGCAGTGCTGGTGGAAAGCATTCCTGAGGGCCTGGACTTCCCCAATGCCTCCACGGGGAACCCTTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCCGGTGCGCACAGCAGCCTGGACATCGCCTCCTTCTACTGGACCCTCACCAACAATGACACCCACACGCAGGAGCCCTCTGCCCAGCAGGGTGAGGAGGTCCTCCGGCAGCTGCAGACCCTGGCACCCAAGGGCGTGAATGTCCGCATCGCTGTGAGCAAGCCCAACGGGCCCCAGCCACAGACGGACCTGCAGGCCCTGCTGCAGAGTGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTGCATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTGGGCAGTGCCAACATGGACTGGCGTTCACTGACCCAGGTCAAGGAGCTGGGCGTGGTCATGTACAACTGCAGCTGCCTGGCTCGAGACCTGACCAAGATCTTTGAGGCCTACTGGTTCCTGGGCCAGGCAGGCAGCTCCATCCCATCAACTTGGCCCCGGTTCTATGACACCCGCTATAACCAAGAGACACCAATGGAGATCTGCCTCAATGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCGCCCCCACCCCTGTGTCCAAGTTGGCCGCACTCCAGACCTGAAGGCTCTACTCAACGTGGTGGACAACGCGCGAGTTTCATCTACGTCGCAGTCATGAACTACCTGCCCACTCTGGAGTTCTCCCACCCTCACAGGTTCTGGCCTGCCATTGACGATGGGCTGCGACGGGCCGCCTATGAGCGTGGCGTCAAGGTGCGCCTGCTCGTCAGCTGCTGGGGACACCTCGGAGCCATCCATGCGGGCCTTCCTGCTCTCCCTGGCTGCCCTGCGTGACAACCATACCCACTCCGACATCCAGGTGAAACTCTTTGTGGTCCCCGCGGATGAGGCCCAGGCTCGAATCCCGTATGCCCGTGTCAACCACAACAGATGTACATTGGTGACTGAACGCGCCACTCTACATCGGAACCTCCAACTGGTCGGGCAACTACTTCACGGAGACGGCGGGCACCTCGCTGCTGGTGATGCAGAACGGGAGGGGCAGTCTACGGAGCCAGCTGGAGGCCATTTTCCTGAGGGACTGGGACCCCCTTACAGCCATGACCTTGATGCCTCAGCCGACAGCGTGGGCAATGCCTGCCGCCTGCTCTGAGGCCCGGTCCAGCGGACAGGCCGAGGCCTGCTAGGCCCCACAGACCCAGATGCTCTGGGTCACGGTCCCTGTCCCGTGCCCCCGCTTCTGTCTGCCCCATTGTGGCTCCTCAGGCTCTCTCCCTGCTCTCCCACCTCTACCTCTGCCCCCACCGGTCTGACGCTGTGGCCCCAGGACCCAGCAGAGCTGGGGGAGGGATCAGCCCCCAAAGAAGTGGGGGTGCATGCTGGGCCCGGCCCCCTGGCCCACCCCCACTTTCCAGGGCAAAAAGGGCCCAGGGTGATAAGTAAATAACTTGTCTG 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@rCer/151/272_58_CCS GCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATTGGC + &,021*-.5.-5320634..0&1696.15#99::0.9:1;144/636183::0.452+336;?>*3=88'@@6A=:6847686<;8?8:>:;<;;8/79C;B==>1;<1635@49=4C>CA<34A8@>5488&=>A=7=6B>9:9=25/+3-,-252)(3748972;38978;76/323/4<73789<4;(+=--1<=.>=>9968;1.=6<4> @rCer/153/2301_58_CCS ATGGGGACTGCAGCACTAGCCGTCTGCAGCTCCGGCCGCCACTCGCGCCTCTCCAGCCTCTGCAGGCCCAAACGCCACCAGCACCATGGCCAGCACCATTTCGGCTTACAAGGAGAAGATGAAGGAGCTGTCGGTGCTGTCACTCATCTGCTCCTGCTTCTACACACAGCCGCACCCCAACACCATCTACCAGTATGGGGACATGGAGGTGAAGCAGCTGGACAAGCGGGCCTCTGGCCAGAGCTTCGAGGTCATCCTCAAGTCCCCTTCTGACCTGTCCCCAGAGAGCCCTATGCTCTCCTCTCCACCCAAGAAGAAGGACACCTCCCTGGAGGAGCTGCAAAAGCGGCTGGAGGCAGCTGAGGAGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACAACAACTTCAGCCGGCAGGCGGAGGAGAAGCTCAACTACAAGATGGAGCTCAGCAAGGAGATCCGCGAGGCGCACCTGCCGCACTGCGCGAGCGCTGCGCGAGAAGGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGGAGATGTCGGGCTAAGGGCCCGGGACGGGCGGCGCCCATCCTGCGACAGAACACGTCGGGTTTCGGTTTTGTTTCGTTCACCTCTGTCTAGATGCAACTTTGTTCCTCCTCCCCCACCCACGCCCCAGCTCATGCTTCTCTTCTGCACTCAGCCGCCCCGCCCTGTCCTCGTGGTGAGTCGCTGACCACGGCTTCCCCTGCAGGAGCCGCCGGGCGTGAGACGCGGTCCCTCGGTGCAGACACCAGGCCGGGCGAGGCTGGGTCCCCCGGGGGCCTTGTGAGAGAGGTGGTGGTGACCGTGGTAACCACAGGGCGGTGGCGTGGGATCGCGGGTCCTTACACTGGGCTGTCTGGTCAGCATGTGCAGGTCAGGCAGGTCCTCTGAGCCGGCGCCCCTGGCCAACAGGCGAGGCTAGGGTACCTGCTGTCTTTCCAAGGGAAGGGGGCTCCCCATGCGGGAGGGGCAACGGGGGAGGGGGGGGTGATGGTGCCTGGGAGCCTGCGTGTTAAGCGGGAGCTTGTTGAACTGGCAGGCAGGTGGGTGGGGGCTGCAGCTCTCCTTAATGTGGTTGCACAGGGGTCCTCTGAGACCACCTGGCCTGAGGTGGACACCCTGGGCCTTCCTGGAAGCCTGCAGTTGGCGGCCTGCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCCAGGGGCCCATGAGCAGGCTGCCGTGGTCTAGAGGTTGTGGGCAGCATGGACAGTCCCCCACTCAGCAGTGCAAGAGTTCCAAGAGCCTCTGGCCCAGGCGCCTCGGTGAGACAGCCCCGCCGCCCTCCCCACCAGGGCTTTGCGGATGTCCTTGAAAGACCCGGCCTAGAGCCCTTTGGAGTGCTGGCCCCTCCTGTGCCCTCTGCCCTGGTGGAAGTGGCAGCCACAAGTCCTCCTCAGGGAGCCCTAAGGGGGATTTTGTGGGACTGCTGCCCACAGATCCCAGGGTTGGAAGGGCAGCGGGTAAGGTTCACAGCCACCCCCCACACCCTTCCCACTCGGCACCCAGAGGGGGCTGTGGGTCGAGGCCTGACTCCAGGCCTCTCCTGCCCACACCTTCTGGGCTGGGTTCCTTCTCTCCTTGGATGCCCAGTGCTGGCCTTGGAGGACGGTCATCTGGAGGACGGGGGGGGAGGCTGTCTTTGTACCACTGCAGCATCCCCCACTTCCCCACAGAAGCCCCATCCAAAGCTGCTGCCTGGCCATTGCTGTAAAATGTGAAGGGGCAGCTGAGTTCTCTTAGGACCCAGAGCCAGGCCCTCAGCTTCCATCCTGCGGAGGCCTTGGCAGGCACTGCCAGCGTCTTCCAGGGCCACACCAGGGACTATGGGAGGATCCTGACCCCTGCAGGGCTCAGGGGTCAGCAGGGACCCACTGCCCGTCTCCCTCTCCCCACCGAGACAGCCCCAGAGGGAGCAGCCAGCTGGGATGGAACCAAGGCTGCCACATGTGGCTTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGGCTGGGATTCTCCTCACGGTGGCAGCTCTCATAGCGAAAGCCTAGTGTAATATGCACCCATCTCATCCACGTAGTAAGTGAACTTAAAAATTAATCAAATGAACAATAACACCTGTGTGTTT 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GGAGCGCCGGCCGCGGGAGCGGGATGGAGACCAGCAGCCGCCGCCCCCGCGGTCCAACCCCAACCTGGGGCTGAGCCTGGACGCCCGGCTGGGCGTGGACACGCGCCTCTGGGCCAAGGTGCTGTTCACCGCGCTGTACGCACTCATCTGGGCGCTGGGCGCGGCGGGCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCGCGGGCCGGGCGCGCTGGGCGCCTGCGCTACCACGTGCTCAGCCTGGCGCTCTCAGGCCTGCTGCTGCTGGTGGTCGGCGTGCCAGTGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCTGGGTCTTCGGCGACCTGGGCTGCCGCGGCTACTACTTCGTGCGCGAGCTGTGCGCCTACGCCACGGTGCTGAGCGTGACCGGCCTGAGCGCCGAGCGCTGCCTGGCCGTGTGCCAGCCCTTGCGTGCCGCAGCCTGCTGACGCCGCGCCGGACCCAGCGGCTGGTGGCGCTCTTGTGGGCCGCCTCGCTTGGCCTCGCCCTGCCCATGGCCCTCATCATGGGGCAGAAGCACGAGCTGGAGACTGCGGGCGGCGAGCCGGAGCCGGCCTCGCGCGTGTGCACCGTGCTGGTGAGCCGCACCGCGCTCCAAGTCTTCATCCAGGTGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCACTAACTGCTTTCCTGAATGGGGTCATGGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTGCCGTCCACTTCTGCCCTGGGCAGCTCTACTCCCAGCCGCCTGCAGCTGCTGAGTGAGGAGGGCCTCCTCAGCTTTCATCGTATGGAAGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTGGAGCCATCGTGGCCATGTATGTCATCTGCTGGCTGCCGTACCATGCCCGCAGGCTCATGTACTGCTACATCCCTGATGACGCGTGGACTGACCCACTGTACAATTTCTACCACTACTTCTACATGGTGACCAACACACTTTTCTACGTCAGCTCAGCGGTGACTCCTCTCCTCTACAACGTCATGTCCTCCTCCTTCAGAAAGCTCTTCCTGGAAGCCCTCAGCTCCCTGTGTGGAGAACACCACCCCCATGGAGCGGTTACCCCTGAAGCCCCACAGTCCCACCCTAATGGATACAGCTTCAGGCTTTGGGGATCCCCCAGAAACCCTGACCCGAATGTCATACAAAAATGAACAGAACAAGCAGAATGACCAGTTGCTTAATCATCTGGCAAAGCAGGTGAGCAGCCTTATCACTAATCATTCAAGCTTTGCAGCCAGGGTGACTTCCACCAACCCCAGCTCTGCTGAGAACCATCAAGTGCAGGGAAGCCACGTGACCCCTCCTAGCCTCAGGCTCCCTCATCTGTGTAGTGGAGATAAGAAGAGCACCCATCTCTTAGTGTTGTCTGAGACTAAAGTGCTTAGCACACAGCCTGGTGCATAGTAGATGCTCAATAAATTTTTGCTGG 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AATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCACATAAAACCCCCGCATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTT + &EF1HG69H=;FEAHH>@4FB:GBIEDG>%C=?D@;2BA>9>A)CF;HBHC4CBD>FFIC=D7DGFJEGGGFBE2GH>E4GD8:IEHHI?FI>G?BC+(:)<=:=B:.:7DAFB=C4HG?EEDF2ED?=@@6:@(9BAD&6:C@<@+99;>8@B/8:31*.4'?@AD;5DGFHIBF@IDIHBAFC:3BGIFCH?3H=64?CD5;D>E=BDAI6BC<6?GBGCGH@@H=FA;/FEAG=>8@>EEFBGFCCEDFIEFFIB=@1EG?8GIH'CBBH=G@GC??=HD.DH>;B62?9GIID3@F:HG4DDBIB?CA;>6=A?:>H>DDFDC>DC*EI.HG=I;E?B8=<;E>I8GB>G8IE28?C=>F@<=E>0?DDEH@?FF4GG=;=9?G?5C-;@H;A6>9A=6:;;B8BBCB$27:C?E5BDDCDF>8:<97:A<2(=8=FE>HH5CBEJHAG:GEEE6B1;??D@@>EJ?HF.@:-@(EE;EA,?A@D=DDE>:CA=@AAE>8C@?EHA7E?@9AAB8@?8&CGC>?A>H>FD4EB4AA<=;B7+GEBD99@;A<:B?:C45*<&,/A8C>D:E5->A;;<75$470=BEH>:=DHEBBC@GC6GE@C8=@C??;=?79:@>::@;C?DD<954B0DC7779;E*3;5385)=3.A>I?;C?>=8)8BAA>H@5HHAB>>J;H@=2FH;9F?;?ACA:2BF@EE=H@:D@IIEB=GI:HFFC:FH==(AB@?9H>A?CB70?2BDIEF7HJCC;FED;<@>=,#9==>E;%7:CCH?FE?7=>4C7D>F<8K=@H2FFJIE=CBHEFDDGCAC/B==AB.AA93>?DFFCG?G@E7HE9C;BB@8H(=AADJFID6>>:ECH@G?CC3?E;?FDIHF?-;8,BA9@A%::8&C;8>@EHB@:A2A@J<&:A75<;C=4@CD?HC(0HHHGIDBIH6E88E?ABABAEFFCIFA?KH@@H?HJCFH@IDJICGGHEIE@H?C3EI?DC2FBFI/EGHJC@9D:6;DH@AB=HHJHJ7IH@J?JKJHKCA@BCA?6<173:8;5@;736:036@=9<=A<>;><<>9>==AB997B8?A59075.:5@9:8362>5?=1=A9@/74:8<::6A;<=A7B><;;8;<.,'B57;;*6975/B?8@@79/=4+;<:??<=80:*99;>46%9=:+<=@<.;=?BA;3=@>97/6=<91963492?:?4?=;7<(:976B-==0?=>AA?A7:56;-:@?97=<@>@2?<3>:A4;A8><1<2177::C>B@&<9:074?=7>9A3=&449,$8687;;,81=C:=@6A?=:=::7/9?+56>99>@=4?=?A=:9.;6<:8>=;?9<1.=6882;<4?=B44'<=;3=>>79B@7A?00861<=<:>@><=B>;;51)3893-::3>>;>=?;79A=C8?976?8<=A?A=BA95:68CCA8&@*09:1?<>4<:3>8C>==>=:@;@A8?73:9;;8<6=6:=>47=4158=9A=?8@/1@;:0>82=5419996===6><;?AA2:70<:0==2791/12077>>)8;;::<928790:*,*:63=/@<;9@9(:,>@A==<787BC;C6=;=:8::7(25:&844=><6?;44-;2*6<5&2/5-+.8:;<7<;;64/6050370*'+7&/588;>8.,)1%*/79:0.39=835+76=)89691+-842899>45=7;817596/046';<99%49819/77<;.2.3=9557>9.3.2,35333325278882/87=66126;+547808=,88(8&3799(:::/.'-87:91677(1(2<;5;>(33885???=883:4:8.:=BA8C@?B@9A:;.35>4.8<79/?>3)1;;)9.('=;@>978<=9896,:9144%05<@ACB?>@EBBCGE23%>7/52(-))'5:8943881/:34>6;;<:6?AC4B7BC@??0A67>?+=;7A9=70==A*/52/@=A-%C8@>:@9$?<<5C1@6@,@777;8/<98-?.@?1;;B0DD?D@D6>426AC1D8398ECDB2=>9A)?DBF3<457D84D@7:?6:89:;CD@<<4235.:;E9C7;%@B=;E:=D59>A@E,1:AC?/>A0=6:@?AFE=98362=@5<<=27@@>@92;?=3CFA>C$=<47AE?E01=:C8E>%.66572?123;:2':5A/?<7BC6:'9?=+AAD0::AAEEA@B@EBB:B==?EFF7?+?=AC%9::<>=;@34:>1=4@>9=?7;GAE;BA<@F@AA>E874,-665#85@@5+<7-;/89:<;=3>=?96D=3'8)#;A>:&837;>AED5:?:A>;627<=824:0>/835:<=<@?8?4;ADA,E?E9=<:8;E0@9AAB=83*/28@7?AD><@>,;*/>1:8@G@BCF=:>>DECC@(6/=;ABCE?CGDCC=@D9-CDBA;12=6@8@>1>:*89CD=E0=2(2FF=5ACC>B965>90:;<=<3;A;)?5?<&79B%58;;@;(>>3:@3<@AB:6<531@6AA7:;4<65/8<AAA6/9+=?;D?69?=<1B=A9@B0A13->%665>FD<3:?8D53<9606@;?24?=:@;A?>9>C-@?=4=>8?;<3<7>96C:+<)-<*199+-?;B74FH<<;>BC;9;/@3D6 @rCer/166/2002_58_CCS ATGGGGGGATCGCAGGGCTCCCAAAATGGCGAGTGAGGCTGCGGGGACTCGCTGAGCAGCGGAGGGGGAGCGTGCAGAGCCGCTTCGGCCCTCACAGTCCGGAGCCCGGCTGGGCCGTGCCGTAGGGAACATGCACTTTTCCATTCCCGAAACCGAGTCCCGCAGCGGGGACAGCGGCGGCTCCGCTTACGTGGCCTATAACATTCACGTGAATGGAGTCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGGCCAATGTACTTCCTGCATTCCCCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACCCATTGCTTGGGAGCAGCGAGACCTTCAACAGTTTCCTGCGTCGGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGGAAGTGCTGCTCAGCAACGGGCAGAAAGTTCTTATCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCCGCAAAGCTGGATCTTCCAGATGACTTGATTGGATACTTTAGCCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGCAAGAGTTTGAGCTGCCTTATGTGTCTGTTACTAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTGAGGAAGAGTTATTGGGACTCTGCCTATGATGACGATGTCATGGAGAACCGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCACCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAGGTCTCCAAGAAGGAGTTCCTGAGACTGGCCCAGACACTGCGGCACTATGGCTACCTGCGCTTTGATGCCTGTGTGGCTGACTTCCCGGAAAAGGACTGTCCCGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGCAGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGGTCACCTCCTCTGTGCCATTGCCCAGTGGAAGCACGAGCAGCCCGGGCCGGGCCGGGGCGAGGTGCGCCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTACAGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTGGATGAACTGATGGTGAAGAAATCAGGCGGCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGCACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTGAGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCTGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAGATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCTTTACCCGTGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCAAGCTGGGGAGGGAGGGTCTTTTCCTTCTCCCTTCCTACCTTCCCCTTTTCTCTTGGCCAGGGGCCTTGTAATGTACCTTTCCTCGTCCCCTGGGCTGGCTGCACAGAGGATTGCCCCTTCTCTTTTCAGAGCTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGGACCATGGCTACCTGCCTTGGGGAGGAACCACAACTCCCTCTGGGCCGCTTCTGGCTTCTTGGGGCCATGGGCCAAAGGCCAAGGGATGGGCAGAGGTCTGTGTTTGGTCTGGCCTAGTTCCCCATCATTAAACTCAGCCTGATTGCTGCC + HKHKKKK/KKKKKKKKEKCKKDKKK=KKKKKKHKKKKKKKKKKKK.KKKKKKKKJKJKKKKFKKKKK1KKKKIKKKKKKK:KKKKKKKKK:KKKKKKKKJKKKKKKJKKKKKK>K?KICEJIIKJBEH9HICDFKHEHIKEKEICJKII.IFGDGHCDHGHJJFGB4KJIKCJKHKAIJIGHJFHCKJIJFBHGEII3IIE>HCJKJCH>EGCJKIDIFIJJHKDKIJ;IKJHCIIHIIKJEHGIKHKHHFE9JKHKC;B7HCII=I18?CEE:@E@BJBJ3IK@IFKIKJD=H,:JJKGIKI@KJGGGCH8I;D@K>HGAJFIA@HDH;5:FIH?JJ>JIKIGH>C>JIJHCGIKIKI=AKKHHJ?K@JAIIC-GDFFDJD?@GF;HG7HKAJI:CIJJKHAD;GDJHJJIAC<>BD-D@HGHIJ2JKKFIJGJ6EGFJJEICDE2JJEDEKBF@HHEKJ>HAHA5FGKIJFDCGBDJHCIBJHK?E?DGG,JGA=78HCEBJD6FJKIIDIHJJIGE@J>HB0=BHHJIJDFEHDFAGIB48FJJ8KFJIIG;IKEF7JKIJHJKKHFGGI?KFJEEHAGJKJE9G?KCIIFI>ICJJAIHKE>B9FGFEFKKKHIKIIGHI)JJJBHKCJCGC@EKKFJGEFCFJFHGFD,8KJK=FDIDDDFKDJHCGAG@IH.HJKJJH>70EF?HFECHGI@JGIED4IJEJFCGIIKBIKCJKJB@JJ>IIFKHG:JEHI>=DCH=EFJ7FHF?FE:FAJJGGFHCJKHIIG8FCEBHHCHJI+EIHH>*A>BAGJGDEHJGFH:JDIBIIJJIHJJCJK>HFGGICHCKKFIJFKKKEHGIDKHKK=>CI/ICBKGJ@KJGKJKJCKIGIFGHHK;KHGKIEHKIGJGABJK;KEBHFJGKKHE=H3HFHDFG=JED4FFEEJFIBD@,IHGH8HHF@HFE@ADHFIIG6DGC6FFF8DHGCB@EH@IHFA?DBCA;;@JGBIIBIHIEB@'DCJBC@9A=;@HFEIIJGCEJCH=FHCAFBE>C8EBG?HI5CFCHFEJJA>HD<>EHCG7FCBAAFC<9?EB7@HFHGHIG?IIHGBEC?EHCGEIG@AIH:H@DJJE>FDEGG0IEGI9CEHDAAGH<7BED>:G84=G?GACFGD>FCH>?=AAD?D7E?HHA7DGCF5DGHAIBGE:=;5GCBCF1AG>>9>A: @rCer/170/1907_58_CCS CCGCGATACTGGTTGCCCGCGTTGTGAGCAGAATTCAACGTGTATCGCTGCCGCGAAGATGGAGGGGCCTTTGTCCGTGTTCGGTGACCGCAGCACTGGGGAAGCGATCCGCTCCCAGAACGTTATGGCTGCAGCTTCGATTGCCAATATTTGTAAAAAGTTTCTCTTGGTCCTGTTGGCTTGGATAAAATGCTGGTGGATGATATCGGTGATGTGACCATTACTAACGATGGTGCAACCATCCTCAAGTTACTGGAAGTTGAACATCCTGCAGCTAAAGTTCTTTGTGAGCTGGCTGATCTGCAAGACAAAGAAGTTGGAGATGGAACTACATCAGTGGTTATTATTGCCGCAGAACTCCTAAAAAATGCAGATGAATTAGTCAAACAGAAAATTCATCCCACATCAGTTATTAGTGGCTATCGACTTGCTTGCAAGGAAGCAGTGCGTTATATCAATGAAAACCTAATTGTTAACACAGATGAACTGGGAAGAGATTGCCTGATTAATGCTGCTAAGACATCCATGTCTTCCAAAATCATTGGAATAAATGGTGATTTCTTTGCTTAACATGGTAGTAGATGCTGTACTTGCTATTAAATACACAGACACAAGAGGCCAGGCCACGCTATCCAGTCAATTCTGTTAATATTTTGAAAAGCCCATGGGAGAAGTCAAATGGAGAGTATGCTCATCAGTGGCTATGCACTCAACTGTGTGGTGGGATCCCAGGGCATGCCCAAGAGAAATCGTAAATGCAAAAATTGCTTGCCTTGACTTTAGCCTGCAAAAAAACAAAAATGAAGCTTGGTGTACAGGTGGTCATTACAGACCCTGAAAAACTGGACCAAATTAGACAGAGAGAATCAGATATCACCAAGGAGAGAATTCAGAAGATCCTGGCGACTGGTGCCAATGTTATTCTAACCACTGGTGGAATTGATGATATATGTGTCTGAAGTATTTTGTGGAGGCTGGTGCTATGGCAGTTAGAAGAGTTTTAAAAAAGGGACCTTAAACGCATTGCGAAAGCTTCTGGAGCAACTATTCTGTCAACCCTGGCCAATTTTGGAAGGTGAAGAAACTTTTGAAGCTGCAATGTTGGGACAGGCAGAAGAAGTGGTACAGGAGAGAATTTGTGATGATGAGCTGATCTTAATCAAAAACACTAAGGCTCGTACATCTGCATCGATTATCTTACGTGGGGCAAATGATTTCATGTGTGATGAGATGGAGCGCTCGTTACATGATGCACTTTGTGTAGTGAAGAGAGTTTTGGAGTCAAAATCCGTGGTTCCCGGTGGAGGTGCTGTAGAAGCAGCCCTTTCCATATACCTTGAAAACTATGCAACCAGCATGGGGTCTCGGGAACAGCTTGCTATTGCAGAGTTTGCAAGATCACTTCTTGTTATTCCCAATACACTAGCAGTTAATGCTGCCCAGGACTCCACAGATCTGGTTGCAAAATTAAGAGCTTTTCATAATGAGGCTCAGGTTAACCCAGAACGTAAAAATCTAAAATGGATTGGTCTTGATTTGAGCAATGGTAAACCTCGAGACAACAAACAAGCAGGGGTGTTTGAACCAACCATAGTTAAAGTTAAGAGTTTGAAATTTGCAACAGAAGCTGCAATTACCATTCTTCGAATTGATGATCTTATTAAATTACATCCAGAAAGTAAAGATGATAAACATGGAAGTTATGAAGATGCTGTTCACTCTGGAGCCCTTAATGATTGATCTGATGTCTCTTTTATTTATAACAATGTTAAATGGAATTGTCTTGTACCTTGACTTAAGTATTACACATTAAAGTACAACAAGCTGTAAACTTGGGTTTTTGTGATAC + /(-,1-*-002.52058283;<5:47>?8@>C>C??>1?>80:=>9@;55;4<4.968/:><:?@?79;??268@?=0160;?6:7>59808<=;?,?,>;89>@89=1A=2><@2@95:8:B4:28;42:-;36=<:&@>A<2:05/4(6)33&67<;/68>36*0C7:;418@;+<>5/7;:80,024BAA>@;3<85@?0)<2:BA>59:9;>;39761?::1<;;=C=?>7>B;:59863-=@:=:4=:9:5<>?:@@8=3068;+9?8<=A;B5>;A<3>2@A79<4:=>=;2:1:749==/6:2<;6:3<4>9>66-:6>C=B<::9=::?@CA*0><;,8=3=?@;>=78?=3>:>@A;3>1B?(=@:*A;9@=8;36;+98?A6=3@;===C:A>?/:87@9*@A89668?7469?:85,229@5=<:=6725;)9+-8;74<5@5:8:89>9<82@?=8C;=;93==<;672;2=(;:<:+<5>;=/=>?66539216<;<:;3380483090,225=:<>A>>8/,54704..---,39:2555385:;981;84;<38$>C>A@<-;?;:9:B,A?>;D=B;7;:95*+,>76?763+3;A;8(<8;>?D8D@;A:035;:;5:>?=A>9B>;A>;07<5D+'<@>A?A4D699?=4@CB=91?5@:6A:E@=BB98/?A?2>=61=149/*64=:C@==76699:C.)%&%-C89?>;7A=:B?>B>%8:A>@B=?6A?@@1;7*:0?ACD6FD=178359<%,5<::)@B>@A;<1AE3D92<99678?F;EFE=:?;9?69>@@D>;;<19B:?9=C<:<&;0>27>@;;ADB@8BA@EEGC?@4B9>>?98'F@C?BCC?C@3142<7EB@>=48;==+=?H?<=C0:5;4-8316&9D;:9898=2B8BEGF5I@BED;?AGFG624DECGFFHHF7CDE>>>FBGA=E8@I:DFDCGEFAG?@@CBABE>9DGFE?D??A>DHEHC@@5CDFE8HHCAB:E@JCF>?>4=BIA@BHDCCE+F?=B8>C6@CEDIBFBDCH>@I?DA@E?7E;GFEFFD;DC*@F7D:=F@66D(?BA=-5=ABC:>;@0FGC?D@E7CB=@D9CIIHED=DFB=>52C;@>9=G@B9D6E;HFIGE@IGEIIGBEEG6GI=DFC1EE5CCACE>BH?>E7FF6DDDBA;AC8B?I;GHDHCCH;GF>HFFDCGJD=89<6B>HFIDAD??C;8?EFE?B?A?7*=ABFBF>6>E3GHFED7A@G99B @rCer/171/1854_59_CCS ATGGGCAGAATGAGAATGAGGAGGAAAATCTTGATAAAGAGCAGATTGGAAATCTAAAACAAGAGTTGGATGACAAAAGCGCCACTTGTAAGGCATATCCAAAGCGTCCTCTGCTTGGACTGGTTCTGACTCCCACTCGAGAGCTGGCTGTCCAGGTCAAACAGCACATTGATGCTGTGGCCAGGTTTACAGGAATTAAAACTGCTATTTTGGTTGGTGGAATGTCCACGCAGAAACAGCAGAGGATGCTGAGCCGTCGTCCTGAGATTGTGGTTGCCACTCCAGGCCGGCTGTGGGAATTAATTAAAGAAAAGCATTATCATTTGAGGAACCTTCGGCAGCTCAGGTGCCTGGTGGTGGATGAGGCTGACCGGATGGTTGAGAAAGGTCATTTTGCTGAGCTCTCACAGCTGCTAGAGATGCTCAATGACTCCCAATACAACCCAAAGAGACAAACGCTTGTTTTTCTGCCACGCTCACCCTGGTGCATCAGGCGCCTGCTCGAATCCTTCATAAGAAGCACACCAAGAAATGGACAAAACAGCCAAACTTGACCTTCTTATGCAGAAAATTGGCATGAGGGGCAAGCCCAAGATCATTGACCTCACAAGGAATGAGGCCACGGTGGAGACGCTAACAGAGACCAAGATCCATTGTGAGACTGATGAGAAAGACTTCTACTTGTACTACTTTCTGATGCAGTATCCAGGCCGCAGCTTAGTGTTTGCCAACAGCATCTCCTGCATCAAACGCCTCTCTGGGCTCCTTAAAGTCCTTGATATCATGCCCTTGACCCTACATGCCTGTATGCACCAGAAGCAGAGGCTCAGAAACCTGGAGCAGTTTGCCCGTCTGGAAGACTGTGTTCTCTTGGCAACAGATGTGGCAGCTCGGGGTCTGGATATTCCTAAAGTCCAGCATGTCATCCATTACCAGGTCCCACGTACCTCGGAGATTTATGTCCACCGAAGTGGTCGAACTGCTCGAGCTGCCAATGAAGGTCTCAGCCTGATGCTCATTGGGCCTGAGGATGTGATCAACTTTAAGAAGATTTACAAAACCCTCAAGAAAGATGAGGACATCCCGCTATTCCCTGTGCAGACAAAATACATGGACGTGGTCAAGGAGCGAATCCGTTTAGCTCGACAGATTGAGAAATCTGAGTATCGGAACTTCCAGGCTTGCCTGCACAACTCTTGGATTGAGCAGGCAGCAGCTGCCCTGGAGATTGAGCTGGAAGAAGACATGTATAAGGGAGGAAAAGCTGACCAGCAAGAAGAGCGTCGGAGACAAAAGCAGATGAAGGTTCTGAAGAAGGAGCTGCGCCACCTGCTCTCCCAGCCGCTGTTTACGGAGAGCCAGAAAACCAAGTATCCCACTCAGTCTGGCAAGCCGCCCCTGCTTGTGTCTGCCCCAAGTAAGAGCGAGTCTGCTTTAAGCTGTCTCTCCAAGCAGCAGAAGAAGACAAAGAAGCCAAAGGAGCCGCAGCCGGAACAGCCACAGCCAAGTACAAGTGCAAATTAACTGCCCTGGTCAAGTGTGTTAGTGACTGCACATTGCTCTCTGTTCTCTGGCTATTTGCAAAACCTCTCCCACCCTTGTGTTTCACTCCACCATCAACCCCAGGTAAAAATGTCTCCCTCTCTTCCTCTCACACCCATAGCGGGAGAGACCTCATGCAGATTTGCATTGTTTTGGAGTAAGAATTCTATGCAGCAGCTTAATTTTTCTGTATTGCAGTGTTTATAGGCTTCTTGTGTGTTCAACTTGATTTCATAAATTAAAAACAATGGTC + KJKKJKIKKCJKKKKEDKKJKKKKKKK*HKKFJEJJKBHKIJKKJKIKFKKEFEHJKK@KKDKJJKJKHGKJKEKKK34E;K@KKJKF3HEJG9KKHCKKK8IIKKFC@FJ2IF>@KIIKFEDEJJK@?EKGIFEJ2KIJK<;HKEKIIEDJ38F5GEKIGKADKKJGH9GKKJD@IKADGDFBKKKKJKJJJKJKKHKDKJKDI;KJJIGKK?JJJKJJKKKJKAKJKKKDJ9FAKKKKKKDKKKIJJKKKKKFDK=EKCIGJ@KEKKJIKJC=4KKHJAI?KIII?EKAKIIKK'HJCFKFKK4H>IIEKK?=F>K?KEKKKKIJEHKIKKKECKFKKK;KI84KK+KKIKKK;JAIFJKJK?IKKKKKKKKDIKKJJKHKFKIJJKHHHIFKFKBIKKKKKKIKKI=JJIKIKJK@??JJKFJJ@JKIHKKJ8HJ@IKHIJD6GGJKKKIJGEEKHGGKHKKKFKKKEJKKKKKKHKKH@HHGBFF@K5H>KAAIG@@H0:GJKIHI9KK6KIJKKJJKKKKJKIKKKKKK-ECDH?HG><9;CDKK=II/GIJ:FJH4HJKKIJHIIIFKKBKKFDBAKK=ICJKKJH?KIJK8KFKJJKJKGKEKICJKIKJ=IJKKJIK=KKKIJJKKFHBKKKKKGKJKKKGJKFJKHKKFHIKKJIKGKCKKKJKCKKKKKIHKKHKGKK?KFJB=JKKKFK=FKGF7JKKKKKBKJKJKJF=GKAKKKHH5JIBIGIKHKIIKKIKKBKK?KKK3KJKKJKKJJJJDKJ@ICHKIKKKIKKHKIKH6KKKKIKHKGKKKHKKKKHKIKIJKJJCKKKKIKKIIJJKKJBD=CKKKAHJKKI=GFI9JBKJJKJJKKH0KBH-AIFKKKKKKJK>IKJEKIJKDAKHJKKKJEGJKFKEHJAIJJKK8KEIKKEKJKKKGIJKJDKJ:0IFCJKKKJEKKJJ>GKGII@EIFEIK9KFHKK9HKDJK@KH3KKEEI>JEFAKHKJGCKIGKFGJHKHJGDEJEKDJIDJGGJIKHEEK7GKKKJKIIHKDKIJE@KBKKIJKJKJ;JJJKKKKKKJKKHKGJHJKKHKKIKH?JACJI4KKKKHJKCJJKJK=KKKKK8KIHBKHIKIJFKK;IKK>IKJCKKKHAKKHKKKKHJIJKB@KE7EKKKJJF(KKKJGHKKKGFDJIKJKEKHKK4KJJJJKIKJ>HA@GF8HKFKGKKJ @rCer/175/0_1099_CCS CCAGCTCCCCCTGCCCACCCACGCATACACACATGCCCTCCTGGACAAGGCTAACATCCCACTTAGCCGCACCCTGCACCTGCTGCGTCCCACTCCCTTGGTGGTGGGACATTGCTCTCTGGGCTTTTGGTTTGGGGGCGCTCTCTCTGCTCCTTCACTGTTCCTCTGGCTTCCTGTAGTGGGACCTGGGAGGGTTCCCCTGGCCTTAAAAGGGGCCCAAGCCCATCTCATCCTGGCCCGCCCTACTCCACTGCCCTGGCAGCAGCAGGTGTGGCCAGTGGAGGGGGTGCTGGCCCCAGGATTCCCCCAGCCAAACTGTCTTTGTCATCACATGGGGCCCACACTTTTCATCCTTCCCCACCTTCCCTAGTCCCTGCACTAGGTTGGGCAGCCCCTTTGGCTCCAGGAAGGCAGGAGGGGTGTGTCCTTACTCCGCTTCACTGTGGCCACAGCCCCCTTGCCCTCCGCCTGGATCTGAGTACATGTGGTAGTGATGGAGATGCAGTCGCTTATTGTCCAGGTGAGGCCCACGAGCCCTGTGGCCGTCACCTGAGGTGGGCTGGGGCTGCTCCCTCACCCTACTTTGCTTCCGCCACTCAGCCATTTCCCCCTCCTCAGATGGGGCACCAATAACAAGGAGCTCACCCTGCCCTCTCCCAACCCCCCTCCTGCTCCTCCCTGCCCCCAAGGTTCTGGTTCATTTTTCCTCTGTTCACAAACTACCTCTGGACAGTTGTGTTGTTTTTTGTTCAATGTTCCATTCTTCGACATCCGTCATTGCTGCTGCTACCAGCGCCAAATGTTCATCCTCATTGCCTCCTGTTCTGCCCACGATCCCTCCCCCAAGATACTCTTTGTGGGGAAGAGGGGCTGGGGCATGGCAGGCTGGGTGACCGACTACCCCAGTCCCAGGGAAGGTGGGGCCCTGCCCCTAGGATGCTGCAGCAGAGTGAGCAAGGGGCCCAAATCGACCATAAAGGGTGTAGGGGCCGCCGCCTCCCCCTGTTCTGTTGGGGAGGGGTAGCCGTGATTTGTCCCAGCCTGGGGCTCCCCCTCTGGTTTCCTATTTGCAGTTACTTGAATAAAAAAATATCCTTTC + ?GDFH;>EHEGFH4AEC9HHHDC;BEE?BGB;CCG?JJHCCF@DFI<>;CD=DFCEDB>$@AA;A1B<:D;@B==B-FD?DA?EBDAC5A<-@F<5E?C2G5GG%>AB@EFEFBC9;29&AAB:F6:F>>4BD;A:FDA@5A4@8A,FC@GI9E?ED)F@>9AEFJE?D@9EHDFFD6?D@ED;+/BE@?GEHCDH?EH)CBAC@@HB3B%CGDB:C6EG1JJJJEA>I4EGACG?E;IHDG;?CGDD:8,HGG+DCBDID3FCIC=GBE8G,FE;@7D860A;3A>B(?<@<=:1?@3=0C)A>98>+>B:9DC:D?C4B:1?:E;C??9?8(@60309?>=A9>?:4&C5??DA:C:>B.?-@<59C6GCCA4=91=??6=?7D=&8*9BB<967;:;@@C:F@@?EB:C3?/-A.B?;B<>@?GD>C?7B3?B@<CD?)@?C8?>2:%C;=@@?CB=:@'?:3:0;7??4>89AD5<1::5AC(:A>9:5E@EC8A;,>?;36=A8GF@FE9DA@9?%>A4D5FB==:399=E'AA;@AA>==9745C=7ADBD&C@=??A8@8AC?BI,++@4CHGD.BAA8B-CDCC.GCAFG<@BFG7@AHEI=HADF9BA,AHIFBA8FCBE9>8A?F@HIH@GDH>A>BCE@ABH?GGIAIG:FIF?BI?C>F=IDJIAEBDH=?>IBGG?HC=FA>HDE2E=GD,B95=?BB%GG:2?CII=J>>>B7>>':DF>9II?4E?A6>DJ?6>DEHEACEIEE6DAH;GEFDF>FCDC?G*IIG>DIDJIH6HI;DEIE:HHF/D?BF4IDJC@DJD;BG8DG=BDG=ACBFAC5B=9,=@5CF?CBFFGC-5:AA=I7DC@)ABFFIIAIF4F9'@DFBDC=DA=G5F4JGFE:HGHADBICC=8DGF=0GC8E=H@A+DFD<=EE7@4GD@J???GFCFCGDE=>B=>;CA)DCBCC@A@=2>&D@< @rCer/176/2869_57_CCS ATGGGGGGGAGGCAGCCGTCTGTGCAGCGAGCAGCCGGCGCGGGGAGGCCTCAGTGCACCGGGCGTCACAATAGGCAGGCAGCATGGGGAAGGGGGGTAACCAGGGCGTGGGCAAGTTCTTGAAACCCCTGCTGATTGGTGAGCTGGCCCCAGAAGAGCCTAGCAGGACCACGGCAAGAACTCGAAGATTCATTGAGGAACTTCCGGGCCCGAAAGAAGACGCTGAGGACATGAACTGTTTCAAGACCAACCACGTGTTCTTCCTCCTCCTCCTGGCCCACATCATTGCCTTGGAGAGCATCGCGTGGTTCACCGTCTTTTACTTTGGCAATGGCTGGATTCCTACCCTCATCACGGCCTTTGTCCTTGCTACCTCTCAGAACCAAGCTGGATGGCTGCAACATCGACTATGGCCACCCGTCTGTCTACAGGAAACCCAAGTGGAACCACCTTGGTCCACAAGTTCGTCATTGGCCACTTAAAGGGTGCCTCTGCCAACTGGTGGAATCATCGCCACTTCCAGCACCACGCCAAGCCTAACATCTTCCACAAGGATCCCGATGTGAACATGCTGCATGTGTTTGTCCTGGGCGAATGGCAGCCCATTGAGTACGGCAAGAGAAGCTGAAATACCTACCCTACAATCACCAGCACGAATACTTCTTCCTGATTGGGCCGCCGCTGCTCATCCCATGTATTTCCAGTACCAGATCATCATGACCATGATCGTGCACAAGAACTGGGTGGACCTGGCCTGGGCCATCAGCTACTACATCGGTTCTTCGTCACCTACATCCCTTTCTACGGCATCCTGGGAGCCCTCCTTTTCCTCAACTTCATCAGGTTCCTGGAGAGCCACTGGTTCGTGTGGGTCACACAGATGAATCACATCGTCCATGGAGATTGACCAGGAGGCCTACCGCGACTGGTTCAGTAGCCAGCTGACAGCCACCTGCAACGTGGAGCAGTCCTTCTTTCAACGACTGGTTCAGTGGACCACCATTAACTTCCAGATTGAGCACCCACTCTTCCCCACCATGCCCCGGCACAACTTACACAAGATCGCCCCCGCTGGTGAAGTCTCTATGTGCCAAGCATGGCATTGAATACCAGGAGAAGCCGCTACTGAGGGCCCTGCTGGACATCATCAGGTCCTGAGGAAGTCTGGGAAGCTGTGGCTGGATGCCTACCTTCACAAATGAAGCCACAGCCCCGGACACCGTGGGGAAGGGGCGCAGGTGGGGTGATGGCCAGAGGAATGGTGGGCTTCTGTTCTGAGGGGTGTCTGAGAGGCTGGTGTACGCACCACTCACGTACTCCGTGTTGGATCTTTCTCCCTTTCTCCTCTCCTTTTTCCCTTCACGTCTCCGCATAGCACCCTGCCCTCATGGGGCCTGCCCTCCTTCAGCCGTCAGCCATGACCCTCCAGGGCTCCCAGCCCTTCTTCCAAGGAGCAGAGATTGGTGGCACGGCGGGTGGCTCTGCCTACCTCCACTCTCTGCCCCTAAAGGTGGGAGGAGACCAGCGGTCCCTGGGTCTGGCCTGTGAGCCTCCCCTTGCAGCCTGGTCACTAGGCTCACCCCTGCTTCAGTTCTTCAGATGCTCTTGGGGTTTCTGGGGGCAGGTCCTAGTCGGGCAGGGCCATGACCCTCTGGGTCTGGCTTCACTCTCCCTGACGGCCGCCATTGGTCCACCCTTCGTAGAGAGGCTGCTTTGTTACAAAGCTCGGGTCTCCCTCCCGCAGCCGGGATCAGTACCCCGGGCCTCTCTTAAGATGCCAGGGCCCCGGCCTGCGGGCACAGCCAGCCCAAACCTCAGGCCCTGGAAGAGTCCTCCACCCCATCACTAGAGTGCTCTGACCTGGGCTTTCACGGGCCCCATTCCACCGCCTCCCCAACTGGAGCCTGTGACCTTGGGACCAAAGGGGAGTCCCTTGTCTCTTGTGGCTCAGCAGAGGCAGTGGCCAGGTTCAGGAGGCGCCAGCTGCCTGGAGGCTCAGCCCCACCCGCAGCTTGTCCTCAGGTTGTCCTGAGGTCCAAGATTCTGGGCAATCCGACCTTCTCCAAATGCTCCATTACCAGCTGGGCAGTGCCAGCCAATCCCTGGCCATTTGGCCCCAGGGATGTGGGCCTGCAGGCTGCAGGAGGGCACTGGAGCTGGGAGGTCTCGTTGCAGCCCTCCCCATCTTGGGGCTGCTGTGTGGACGGTGCTGCCTCAGGCACTCTCCTGCTGTACCGCCCTCACTGTGTTTAACCTTTTGCTCCAGGATGCGTTCTGATAGAGTGGGCAGCAGGCCTGGCCTTGTGACAATCTGCCTTTCACCACATGGCCTTGCTCTGTGGCCCTGACTGTCAGGGAGGCCAGGGAGGCAGAGCAGGAGGGAGTGTCAGCAGGAGCTGCCCTGAGGGGCTGGGAGGGGGTTACCTCATGAGGACCAGGGTGGAGCTGAGAAGAGGAGGAGGTGGGGGCTGGAAGTGTTGGTAGCTGAGCGGAGGGGCAAGTGAGAGGGAGGGAGGGAAGTCCTGGGGGATCCTGAGCTGCTGTTGCAGAGTCTAACCCACTAATCAGTTCTTAGATTCAGGAGGGGTGGGCACCAACAACTCAGAATGGGGGCCTTTGGGGAGGCGCCTAGTTCTCCCAGCTCTAACCAGCCAGGAGGGACCTGCATCTAAGCGTCTGGGTTGCCATGGCAATGGCATGCCCCCAGCTACTGTGTGCCCCGACCCCCGCAGAGGCAGAATGAACCCACAGGGAGCTGATTGTAATGTTTATCATGTTGCTTCCCCACCCCTAAATTTTTTTGAAATAAAAT + *++,++'*#*,+++&+&+(**&),,(,,(+(++$*'+*,)+,-+**-)-,+++('*(*)(++(,*'(,*.+-,.,-,,**'((&&--+')+,*(()$+,,((*,,'(&$*,%(**)-+(-(,,)%'*%%+'+$(,,-)',--)*,.+-..,,++(+++-*+,+$,-((--*#*%%)&(()++(,.--,("#$,+(%+''%(-%(',,(,'#*('$%,'*''$+-,*-*,)++,+'#),*+&-.**-..,)+(.+%$)-,.200,.1*/2.00112,.2-01../12--/*/)1.--&--+/(***++&)(+,.0,+./-0')//.%/*02*00,//0*/2,/,0(-)(0.'0+$+0*/)//+//0+2/,-)#''$&(%+0*-2-.+'0.2,%+*&.(/11*-,#,.1/0*1/.0-.).--11/010(.11012-)*+%0)+&*)./1+/.-0/+',-++,/-./,,*+'+0,2.*(,(/,2,,,((*)/*/,*/0-0,/*,'',+--.-),-0-/-*''2/*++''''*/0/0&'00/.')%+*-.2-,)1..+./)1.11--011-./*-.-'.0111010#0-0-121+1,+%*-+++---+0-+%%/1.*-).--*&,1,/+*,2/01,0-/0/0*.*/2.0,/1(*-.'(1//,*'0,,2-.100+''2/..+(10.11./--+)*+&')*&*+-'))*,),+),+--*$&,-,',.*'()(&,)$,+$)&(+-,((,-))-)'*',.+.+---(.*())---*),-+(%##+*,,-*,-)+*(-'),&&,,-',+%&,-*-,*-)+')*(%))))&&+%,)+&(&)**',-(())(+-'+(+*,**('+(-*--*-*,(+)(,'*,$,,,**(#(,()*'----+)(+)($)+&&&%)-(',-),-)*-+,&+'-+)(+*()(&+&*&%*-,+',,*)-,-(,'*$*'-,()&,+)**,)*&(%(#""%'('*(%&'(+'-)*&*)%&'$$&#%&&$-+,&,-(-,)+((&&)))&%""""$'(&(+*&))'+'++*+((&'()'&(+%$'$%$%%&&%&%'(*#+(,,,+++%()+-*,(,),+*%)&+('(+'+))&)-**(,',-*-,+),-)**()*'&(*+'',,)+--.+--,,*(,+()%((#+--.**),--*)-*.-------&+).+)++)()-.),-+,+,,&,--)*-,*--,*-.+.,(,+,,-*(,-),,)+-(,+*,.,(*',)-,(),(,,),'-(,'+.,).,+,.-,(*''$)'(''*$(*(')-),,*$%(('()$,-,',,*)*+)-+&*,-,,*-(,(*(*-*,*+*()+)$)+&+)+',,,+(,+--$+,*,((*(,-,)+$**+(')++,''%,-.,-*,)---),-)$,.,-*),--*+,(,,)-+.-+(,+-.*(,'(-)'#%)-',,--#*+),+**-+.-+,()&((,+(.+*%$$+),(+-+),.+,,+'#)&+,.$&-+)+(*,-*)-,&'&(,$-++,,&&&',,*.,-+()&+-+(*,+&+)(+++%))&$,-,)'+-*(*')$&&*,-,%#$$$'+,')(+*+*,&)(,-*,-).+-.+--,,),-),,+,*'&*-)+(&%),'--.,,+(*)#+-++(++*(%*$&-*'(,&,+,..-+,,,)+.++))-,*,.,,)+*,(+(,(%',,-(,,()(&#-$,,'(,-+((%#*)*--),.,,+()%+-,,--(*,,-,(++,',-()*&(*&&'*))%$+'+)++(+*,)$&,*.*+-)&-,++,%),*#'&&#+-*,+&+--**)),,,.-..,+''(&'$')(,+(-+,,++,+(-(+,++(,--,--,--,)+--*,-**#))-*,**$+)++-(+*-(,,)*(*,,,-))*,-&)+-,*))**%,,--,*(*',-()-*+,&--,('%),+(-('+)%'))--.-+)*-*--)+*,+,+-*,.,,-*-'(,(((-,,-.--,''$,,-.+-,))('&'*-,)$')%%&(+*.+,)-,,,*.-*+)),(')'))+-(-(+(--+).#'*&%+,-)$*$,,-,-(.-)-,'&)&+-*),)+$*)(+(*'*(+.,,-.,,)-*--'-&-+-,+'+'-)'%*+,$'+,'*,#,)'+--.,,'',-)(,..+($()-*(+,(&$#+)%,)%,,*--,---+&()+(##(+,*+--(,+(*---+-.,+,.*+-+),-(+-++%))&()'+&*,$,,,)%"'),%+---,-),)+(-)-+++'')*&*)+,,*&+,--*,-,(,+&)&,-.,*$$**-&+)*+$#"**'((+,-,-+),+)..++(,,--,')%,+.($(*)(,+*,.*,*+*+*+--*-,+%,%'(+..,'-,*'+*,(*('+.,+,-*((-,--,()*#++,--*-&*-)&)(&''#+----*-)*-*)*-----(+.,)-.*++)+-,,*-&+',+---*++,-+*-,,+,)-'''++,*%-(',()-*-,,*$%%,+%,.,+--#)+--'**)%),*(*&&*(%'))),$,-(,--(,--,$%)*'&,,(++--+,())$*+(-,,)&',),-'(,((),+)$&'&+$(,.+)(-+*&,.,)((,-.,(,++*&+',)+)))&(-&(',)%+-,)&+(($+)+*--+$'(-,-(--*%"+$,-*--)-*(),---,)*')+',+-.+)-.,*()')(+&'*,+()&-,**#++(,--,+,,%*,,,++$*)+)+,*-,(+(+,-'*+#',---)+,-+',.--,-)-+*--+$+--,+&,,(,---*-+-.++++&(+,,,,%,-+&%),+$* @rCer/178/1293_57_CCS CCAAGGCTCAGGCCGCTGTAGATAACACCACCTGCCATTGCCCCAGAACCGGGACAAAGAGCACGGTCGCTCAGAGAGGCCCAGGTACCAGTGCACCAGAGAAAGCAGGACCAAGCCTGGGGCCCCTGCCTCCCTTGGCCATCAAGATGATGTGGAACATCTCGCAGGTTCCTCAGCGAAGCTATCTGAACACAATGAGCCAGGAGCTGTCCCAGCGAGCCGAGTGGCTGGCCGGGAGTATGGAGCAGTCACTTACAGAAAATCCAGAGAGGTCCCAAGCAACTAGCCCTCACCCAACATCATCCGGGTTCTCCGCGCTTTCACCTCTTCCGTGCCGCTGCTACCCGGGCGCTGGTTGACTACCCTGATGTGCTGCCCCAGCCTCACCCTGAAGGCCTGGGCCACGGCCGGACGCTGTTCCTCGTTAGAAGAACTATCCTGTACCCTGCGCCAGTACCTTCGCGCGAACACACCCAGCCCCGCCTCGCCACCATGATGATGCTGCAGCGCTGGAAGGTGTGGACCATCTGGTTAACAGGCATCGCGCACAGAGACCTGAAATCCGACAACATCCTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCTGGCTGATGAGGATCGGCTGCAGTTGCCCTTCAGCAGCTGGTATGTGGATCGGGGCGGAAACGGCTGCCTGATGGCCCAGAGGTGTCCACGGCCGTCCTGGCCCCAGGGCAGTGATGACACAGCAGGCTGCGGCTGGGCAGTGGGAGCCATCGCCTATGAATCTTCGGGCTTGGTCAATCCCTTCTACACGCCAGGGCAGGCCCACCTTGAGAGCCGCAGCTACCAGGAGGCTCAGCTACCTGCACTGCCCGAGTCGGTGCCTCAGACGTGAGACAGCTGGTGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCGAGTAGCTGCAAATGTGCTTCATCTAAGCTCTGGGTGAACAGATTAGCCCTGAAGAATCTGAAGTTAGATAGATGGTTGCGGCTCTCCAACAATCGGCTGCCACTTTGTTGGCCAACAGGCTCACAGAGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTTCTCTGCTCATGGAGGCAGCCCTGTGATGTCCTTGCATGCAGCTGGTGAGTACTAAAAGAACTTGGCATC + *''$&#&($#%$)%('$######&"#%)($(%''&$"$$#$"##$&(&$$%"""$%#&(%%&&%&$#%#'$$%$'$*,++*$%'&%'-,+-**%((%#%&&*''&,++(,-*,&%#""*,,%%,-()*&$#)-)+&,&-')+'-*'++)+#'')*+%%&&%''&*)&$-*)('#(,,,)(+&%))+$)()*+,*)')&',((*&+'()#%,,('+((((+('&(,,&$#+++&++#)%&',-,('/1,0/*+.+/,-,/0/*--+'.10,/(/..%1(,,-&-(*(12((,-'-$(&,'+'-+-(-1,0+/02.10.000).+,&%',&-.0*01*110-..+-*&21)#"%*/*1+,/-,*+,&.+-&+)$/,/.-,&$$%&$#-//+'*0*0.1.451)/./5606-/+.2-+351%1,)/.+)$(2,21*21,*2''+'+04,52,46433232'.'.,-%.0.(-*/1142/131/%%+)*)1,*-/(*.-00311+-(/3-1),/+53)(,(1+-242602,(35.,#**403$)44,1&+')()221+0&&10,+-6,/./1+/041+#&+./*4250).1-%*3,*60-0./0.(+3-.(0*.3.+0%..1'-,4%0+.332,)#'-'//,++,%$"$-/5.$..3/442551.+*0%3525/-3-/.-310*011656151/1/).,'3513/%.*40../%(433()-/5+,/)$4$2+6/041666354210/-+3*#**&*-+,,%)-/.%!!#(1-5/400,01(4/5,4)*1//.-(31'+/2.100)140(#)450466,/,1022/%12.31/-,#+&),&+.)1+,*%,)//2/+0)+-0,23146//(241/*161642((&./.$-/0.-/'*13,(#,/3-(,.5340*0+--$--262+,01112)+)0%54,0(+'+'+110+-&+/.&,00+,+''/0)&0,+,0,-&+//,,+%(,11---.&%,*..%)*0,11(&&$*0/.',&%'-1-,-'+''+.),-./)&&(--1*&%('+'**0-/%/20100'.-02.+-//&25/4'1'*$1,5*$+.452522214)33%40526.21-.0112'324/41-+5/566/+5.2..0'2/42*+.&)&&**'.0/,*&(+)/0'0,-22-)/+-+110-11111+,))1*++)).%01111.10/+1/,+),/---+'.+,,$"#*/*%'%#%'$/1+0)&'$- @rCer/180/0_1232_CCS GGAGAGTATTGAGCCAAAACGTGCTGTAGCAAGAGGGATCTGGAAAACCAGGGCTATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGAACATCACCTTAGAGATTACTTTGAGGATATGGAAAATTGATACCATTGAGATAATACTGATAGACGTCTGGAAAGAAAGAGGCTTTGGCTTTGTTACTTTGATGACCATGATCTGTGATAAAATCGTATTGCAGAAATACCATACATCAATGGTCATAATGCAGAAGTAAGAAGGCTTTGTCTAGACAAAATGCAGAAGTTCAGAGTTCTAGGAGTGGAAGAGGAGGCAATTCGGCTTCGGGGATTCGCGGGTGGCGGTGGAAATTCGGACCAGACAGGAAGTAACTTCAGAGAGGATCTGATGATATGCAGTGGACGTGGATTGGGATGGCTATAATGGGTATGGAGAGGGCTGAGGTGGCAATTTTGAGGTAGCCCGGTTATGGAGGAGGAGAGGAGATATGTGGTGAGGACTGGATATGGCAACCAGGGTGGGGCTACGGAGGTGGTTATGACAACTATGAGGAGGAATTATGGAAGTGGAAATTACAATGATTTTGAATTATAACCAGCAACCTTCTAACTATGGTCCATGAGAGTGAAACTTTGTGGTAGCAGGAACATGGGGACCATATGGTGGAGAAACTATGGTCCAGGAGGCAGTGGAGAAGTGGGGGTTATGTGGAGAGCCGATACTGAGCTTCTTCCTATTGCCATGGGCTTCACTGTATAAATAGAGAGGATGAGAGCCCAGAGTAACAGAACAGCTTCAGTTATCGAAATAACAATGTTAAGGAAACTCTTATCTCAGTCATGCATAAATATGCAGTGATATGGCAGAAGACACCAAGCAGATGCAGAGAGCCATTTGTGAATGGATTGGATTATTTAATAACATTACTTACTGTGGAGGAAGGATTGTAAAAAAAAATGCCTTTGAGACAGTTCTTAGCTTTTAATTGTTGTTTCTTCTAGTGGTCTTTGTAGAGTGTAGAAGCATTCCTTCTTTGATAATGTTAAATTGTAAGTTTCAGTGACATGTGAAACTTTTTTAAGATTTTCTCAAGTTTGAAAAGCTATTAGCCAGATCATGTGTATAAGACATAACGTTTTTCCTTTAAAAATTTAAGTGCGTGTGTAGAGTTAGAAGCTGTTGTACATTTATGATTAATAAAATATTCTAAG + S'-*-2*-$5*45-0*383035-56.487.+0.1&#$''*)26%72.&31(57,-+8333:98726&84+9+4)0'75312-337:&31:,538.95,51-55,%1)733664.504610&7)1/6,74530+&(.-3:):40/9535--9429406*)16-*4<556/0/0$5*6,34<7'&251227:/>?7?:4??65?96%8<65/-3'401073)426$/1/;?>44985/667/1'656,%0+30)2/4)203;28:-;;::/1;7:84165/:1>;/9,46408529%3&;799+,4:15>>>;21698272>72=/:9978075(0-35$3927*)6.):=5289879./94&64&93-9->+$<56=4092$8(21:66=55?'.=6973$)39995'68/$140+%573.*1-2:;;:2)7-9>72.;7503.60+==;80(01%%,8.$1)6)8,)==*:)=9*%/&.55/'8;*9.;240>8%-+%))+739(00382%2)0,-4,36$33:9469/>.-88>:/+7.<9)44./<778,66+%&6,672,5(9))-)9'4)5698=244+094++&22'595*&(156'3)(.,52)+13%3+:242&0,3*,.23,3/941:5'-5320-++6/)0-496+380,16:4%+0(4%300+'+&)'/-8$$''%/-,2-5743/5-:31:+/,2&63*643-663280-06985/)486+&/.-%(53.4---%34616*.6;54639435.&431'+:689.-914.30.235*.'7,-/::,2-*752(/36-4*&4/613.9426..4/37645&0+744/25483),1+'+/5230,313/68/+57,71)37.5135:3747/+.)'-5372-4-2&77'262-,69&76&5,:,0/,0.1&7556796438172::88655-&%3+1;9/5'72/+4-33.34/772%3',,1-0851&333*$%-,,/2&/154,546)4060+04(4*-0-1,2/63&0(-)3//641+*/25352+3+)4)%(.1012044.$2,.342$2*$230&/22/.),1235,5.-)/)..)%%'&.)-/5521/44/'4433-0,2+#21/2/55&0050(*555465550/2)()..*,1,4&/0+(%2+%*).#0)4)/264-$%/2,#/0 @rCer/181/21_1807_CCS GTCTGGTCCGGCGGTAAGATGGCGGCTGCCGCGGAGTGCGATGTGGTAATGGCGGCGACCGAGCCAGAGCTGCTCGACGACGAAGAGGCGAAGAGGGAAGCAGAGACTTTCAAGGAACAAGGAAATGCATACTATGCCAAGAAAGATTACAATGAAGCTTATAATTATTATACAAAAGCCATAGATATGTGTCCTAAAATGCTAGCTATTATGGTAATCGAGCAGCCACCTTGATGATGCTTGGAAGGTTCCGGGAAGCTCTCGGAGATGCACAACAGTCAGTGAGGTTGGATGACAGTTTTGTCCGGGGACATCTACGAGAGGGCAAGTGCCATCTCTCTCTAGGAAATGCCATGGCAGCATGTCGCAGCTTCCAGAGAGCCCTAGAACTGGATCATAAAAATGCTCAGGCACAACAAGAGTTCAAGAATGCTAATGCAGTCATGGAATATGAGAAAATAGCAGAAACAGATTTTGAGAAGCGAGATTTCGGAAGGTTGTTTTCTGCATGGACCGTGCCCTAGAATTTGCCCCTGCCTGCCATCGCTTCAAAATCCTCAAGGCAGAATGTTTAGCAATGCTGGGTCGTTATCCAGAAGCACAGTCTGTGGCTAGTGACATTCTACGAATGGATTCTACCAATGCAGATGCTCTATATGTACGAGGTCTTTGCCTTTATTATGAAGATGTATTGAGAAGGCAGTTCAGTTTTTCGTACAGGCTCTCAGGATGGCTCCTGACCATGAGAAAGCCTGCATTGCCTGCAGAAATGCCAAAGCACTCAAAGCAAAGAAAGAAGATGGGAATAAAGCATTTAAGGAAGGAAATTACAAACTAGCATATGAACTGTACACAGAAGCCCTGGGGATAGACCCCAACAATATAAAAACAAATGCTAAACTCTACTGTAATCGGGGTACGGTTAATTCCAAGCTTAGGAAACTAGATGATGCAATAGAAGACTGCACAAATGCAGTGAAGCTTGATGACACTTACATAAAAGCCTACTTGAGAAGAGCCCAGTGTTACATGGACACAGAACAGTATGAAGAAGCAGTACGAGACTATGAAAAAGTGTATCAGACGGAGAAAACAAAAGAACACAAACAGCTCCTAAAAATGCACAGCTGGAACTGAAGAAGAGTAAGAGGAAAGATTACTACAAGATTCTGGGAGTGGACAAGAATGCCTCTGAGGACGAGATCAAGAAGCTTATCGGAACGGGCCTTGATGCACCATCCAGATCGGCATAGTGGAGCCAGTGCTGAGGTTCAGAAGGAGGAGGAGAAGAAGTTCAAGGAAGTTGGAGAGGCCTTTACTATCCTCTCTGATCCCAAGAAAAAGACTCGCTATGACAGTGGACAGGACCTAGATGAGGAGGGCATGAATATGGGTGATTTTGATCCAAACAATATCTTCAAGGCTTTCTTCGGCGGTCCTGGAGGCTTCAGCTTTGAAGCATCTGGTCCAGGGAGTTTCTTTTTCATTTGGCTAATGAAGGGCAACCACCCAGAACCCAGAAATGCAGATTCACTCAGTTTAATCTTGAATGTGGAAACAGTTCACCTCCTCCCTTCATCACGTCTCCATGTACTTAGAGCAGTTTCGTTTTCTCAGTTGGATGCCCTGTGTCTCTGTGAGTGGGGTGGAGCAAAGGGAACCAATGCCGAAGACCGCGGGCAGGGGAGGGAGGCGGGGGTGGACAGGGAGGCAGCTTGTGAATTTTTGTTTTACTGTTTAACTTTATTAAAAAAGAAAAAAAAAAGAAGAGAATAAATGTTTTGAC + 6,&88;5+73553:;5>4<50?5/1:=BC=?F:5==AG>:DA6AB=B:EB>;0HG=C?IFHG:FFHIEGII&C@:;HFGGJD?9ID9B>DFGG=B?8AEF2G,=0>9-?7<839=%5==B:F3=D9AGG7/',@EA5FGDEHD@HD==?CDF@$IGB;>DFHHGG>68C5@IE,?FGI;JKKK;KKJ@KK3KKIKKJ:KJKKJG=-DK;9HFKCJ:KKDIKJCKKKKKJKK?KKJKKJJJDIJKJJGKKH1HGG>DKKJKJC0KKIJJIEGKGJJ=F>KKHDHK>FAJ@D>KJHKIDE,EI'>?BBIHKB5FFKJIKIKJCBCKKHJG-GGGJIFI8CEFIHIH8B3;43EG?2KFH?.FF@I2IKG;KHJ2K;$JJKJJJJEGKKKK4KBK?KKCKKCKE%IH+GGG/;*HDDE=K:G?,B=I>G'FBC7KKC;F@JEJBFH@KGJJIKKKE>@IKKKHKJJKAKH%FDIGJKHI:=/KF7KK:JKKKKHGKK=K>BGK?=E@I@AH?DJAI@HH7GD*A>C86HHJFGJIJDFFIJGIDKIGF9JB=G>CK5H6=F/JGFBDI>IJKI@@KCE6JJ3IH7DJHGGFFJB8H?HK1CG?G@AH7BJAKDJ8E7JEJJ=JKIFJJ?G=IHKEF;0JC0/4<>HDBCJIGAD=*KIFHCKKI.JJK@:.:9>=80><8=/==?>?840+.65;:;>5248@9:4?===?6=88;98-4312:$;3=<>8;3;86<9<202,*/690?;7653042':BA@<7@<>3=:4:.<==996>B<6/;82/3592:5.'+<913643?;>?69A88??>;8@:85?CA??::<<=4B<69;55.,/96=.95?4@8@;?.>&?:8%7;96>:<3246::);7252-:;<4?@;5,.;1@97;3=A:3BBA><218:9'64-7<><<:9210.+4;6;859>41+$>A@9:1;<::9,=4=AA=A4=::57<=BA>;8-;AAA<6:8@62>$;3>5493$;9@8@B2:A7@@:>=:5;>694>9?6;:<2:9C7=C-A;0A<;=A@>;<6836@:<>/=B5;88;<7:+??;17,180;8@9@9@;;73..5877=@=99399@?1@@=9.5B718:8,/:7056=/B@?>A8@;3-4;A?=B9>0;5A;A=:A6:5;:=9;<=;:B<;<:;A;8964BAB@6579<@B;B>?6<4>CC==B=<@15348:=>:AA4==;6:<63::23?=5?:-A=<=?4=@6<<1?9>/@;A:;C??:A6>=?>@@@6@>5;B5??,B7BA3@?===@@>6>7>9;969/:A5;>=6;1:>98'<4?<;A9B98?>7279:??7B<<=52==4>BB@782;:5<>4*:;;;/:@7:@65.<<@664<<=9C8599>:B?;;:BC>=>6<@==;7?471-:<77=1:==8BC;7=?;9<:<56=?<8:7;-9=1:<9;0:<)<;;? @rCer/183/1555_56_CCS ATGGAGTACAGGGTCGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAGCTGATCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCTCTAGCTAGCTTAAAAAAGCCATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATCGTGGCTCATTGGTGGGCAGTATTACTTATGGAATTGCTCTGATCATGCTAATGCTGGATTATTAAGATATGCATGTTCACACTCCAGTAGTAATCCAAAGTTGCCTCTCCTAAACCACTTCAGGCCTTTAAAGAGGAGGAGACTCCACAGCCATTCAGCAACCCCAGCGTCAGCGGCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCTTGGTTCTCCTAGTGCTACAATGGGAAATTCACTCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAGAAAAAGTGCAAGAGATCATGTCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCTGAAAATTCCAATTTGGGGGTGGGAGGTGAAAAGGAACCCATTTTCTTATGAACAGATATTTTAACTTAATGGCACAAAGTCTTAGAATTATTATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTCCACTTGCAGGCAACTTGGCTCTCAATAAACTTTTACACAAATTGAATACATATATTTTTTTCAACTGCCAATCAGGCTAGGAGCTCGACACTCAACATTGAGACATCATTGCAATGTACTACCTTGTTATATGCAGAATGTATTTCTTATGTACACTGTACTTCTGTGTGCATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGTCTTAATGAAAATTACTGTTTAATTGACATACTCAGATAAAGAGAATGGTGGTATTCAGTGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAATGAAAATCAATTTACCTTTTTCTTATGATGAGTTGGTTTGATACTCATTTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTATGCTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCATATACTACTTCAAAGTTCATGATGTAGATGTCTGGTTCTGCTTACGTCTTTAAACTTTCTAATTCAATTCCATTTTCAATTGATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCATGAAATGATTCTTTTATTTGTAGCTACTTATTTGTGTTTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGCTGTGTCTTGGCCGGCGCGGTAGCTCAAGCCTGTAATCCAGCACTTTGGGAGGCTGAGAGGCGATCCGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCGTCTCT 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><=-1/678636&0$'19?>>;81740(=&=74?:6*'553;96?<85468827-:<:50%0)&/62)8:1=:9>9;?;;32512&:4<>:983=5;762)2.7:.,%;79;63:4638721-6:1746950,118:37<1+366=>==:-:=144331%7=71$320<81)9>56794):9:+4:9<;89;;985:%>.99=>>=33::9*35;71840&1450<)>6;59==96252:3+672;47*379-65$7:;;=40./758%.7=98:47959*)376>:3(5<09=454,(20/#&6-927-8(87:3$/6(%':?5??75-6.76'0.-'77.9303=);;5-99><986:)/89875<>96/:<&278'18238;4;=>6<99-2515/-5<0974/7;5487;<3788:(7%+,9/70-$#%3+'+2-7)59+545#3,"&).446./8&89355%9-99934-2(021555,)959429487%13$27364)-07.5664325&.233,&6428435006/05284:5544057',*&84'636(-(;6::1587(25.1%+-574':7:1;864(9783.2:208*..%$.-&4.4(00%*(28*77+7.6:5551.*3625,5636-7547+58422*3585-83)($(22(94513227'340;414'0/;3853:9:356:6439:6.275'49:6:648(/3&-:5;9:70796)/1.%5:69/53101112.**&-32+434557/./0%34+*3-1*20+&%013,23./&1,63,&##242,'56-(111.*44(1-('))33.*".(223213*7748,,-.$)/43625&610514.3/6*1/+/&4252(2.414%+,7733.356:6'4-57<1864:75/)9:2597*-4/732.747*13(,)/-$0073-&76761$+1231,01(3(4'7.107:/060%.:6%&,776+10%673948.7540587',:333(45605.65.32-343232*9:7322&34'02783-05:248472%4467&'/&15865%234-2$64%3,773378888856%749..3407402,159596546+2*)+*/558196::9/'93.3.80:662,9/454920331670367/82041-+-./,.2483216915::/460-40023//583750.2-&7%357:994.80035$06055:7:63(:26:2;5:/2657$8:/;805501(4667+,33%,1/81)2279+/46/310&6254375#7':8-60)12/684'214+3-0+'-0-6.951&.3)761#+/6868364693)3349657091'+5998-55973-.25524.53-*4848-97986798900(5-1#+3*1&,45589:/46/63*2,36*3097%65)6--.3,150*/&.'/$$/#(1-//55,60+5-//*50//,**)'-./-2302645-0044-3/'0&3540 @rCer/184/1927_63_CCS ATGGGGAACATTGTATCAGACCTGCTACCTATACTATGGTCTACCTCTCCTCCAGTGGAATTACAAAGGCACTAGCTGAAATGCCTTCTAGAAACAGAGAAAATGAAAACTACTTACCTACTTTTGATAGCACGGATTATTTATAAAACAGATTGAAGTAACCCATTAACTGGCAAAAAGAGAATGAGATCGGATTTAAATGTATGGCAGTAAGTCCTATTGATCCCTCCAGTTATCTCAGTATGACTGCAGTATATTCATTCACTAAAACCACTCATTAGATACCAACTACACACCTGGCACTGCAGATGTAAAGGTCAGTCACACATGTTCTGACTTTACAGAGTTCACAAGTAGCAGTGGAGGAAGATATATGTGGAAACAAAAAAGGCATCGATTCTATTCAGAGCACTGTTATGGCACAATGGAGAGAGGGGTCTTTCTACCTGAGAAGATGAGGAATAGGGTCATCGTAGAAGTGACTTTAAGTCTTAAAATTAAGAAGGGGATTCCAAGCTGCTTCAGGCAGAGACACACCGAGCTAAAACACAGAGGTATGAAATAGCATGGGGACTTTAGGAACTGCACAGTTCATTCTAACAGGAACAAAAGGCTCAAGGGTCAAGAAATGAGGCTGTATGGAAAGAGGTTCAATGTAAGTACTTTATAAAATAGATTAATTTCTGATTCAATGAAGCATCTCTTGATCATTGTGTACAAGGCACTAAATTCATCATGGAAAATTCATTAGGATGCATTGCCAGCACTTTGCAGACCTGATGTTATTCAGCCTCAAGCTTTCCAGTGGCCAAAGGAAAATGCTGACTGCTTTTCACATATTTGAGTCAAAGATTTTTTTATATGGTCAACGAAGACTAATACAAGGGCAGTGGGATTTTCACAGAAGCATGCCATGTTGTTGAGAGCCTCTTAGATCTTCTCAACTGTGAGAGAGAAAACTGAAAAATTTTGAAGACACTGAGTCTGGAGAGGGGATACCAATCACTGTCCAGTCAGGCGTTGGTGGGAATGGGGAAATGGCACAGGAATGCAAGCCTCTCCACCCTACCCCCAAAACTCCAGCCATACACTCATCATTTCACAAAATATAAATGAGTTAGCATTAAACATTTCAGAGTAAATAATTCCTTTTCCCGAAATGCATGAAGATAGAGTAACAGTCTTCTCACACTGTATTTTTAGGGTATGGAAAATTTAGAAGGTTAAAGAATTACTGCTTCAATTTTTCAGTTAAAAAAAATCAGGAAGCTCTGTTCATTCAGGCTATGCACCATGTGCACAGTCAAGAATTAGCAGAAAACCTCTGCATTACAAACACTTTGTGCTATAAAAAGTAATTTTTAAAAAGCCACTTGTGTGTGTGTGTATATATATATATATTTAAAGCCAAGGTTTTGATACTTTTTTACAAGAACTGCAAGAGAAAACAGATACCTGTCCAAACCATATACTTTTAAAATAGCATTTTTTTTCCATACAAGCTGTTGTTAATTTGGGGGTAAAATGCTGGTTTGCAAACTTCATCAAATTGTTCCCAAGTGGATTTTCCTTGTTTGTCTTCCCCCACCAACCCTCAAGTTACCATATTCGATGTAAGAATCAGGCATGTTAGAATGTTGTGTCACACTAACCAGTTCTGCTCTTTTTGTCTTTTCATTCAAGTTCCATTAGCTTCTGTGCGCGGTGCCCTTTGCAGTCTGGTGTCTCTTCCAGAGGCAAGGGGCTGAAGATGGCGTGCTGCATCTCACTAGCTGTACTAACATAATCTTGGTAAACTGAAAACCAAATGTGGACATTTGTAAAGTCAGTGCACTGTTTCTAGAGAGAGATTAAATTCATTTTT + 6=:?>9A25AB@DGEECD:4;89495D8CFCE5<6@)9DEE3;1CBEFFA;8EFF8CFD8G6>DA9@?*;<>?@@EE7>?CDD6B/A?DDCG5@DBFDAAEFG=FCEE?C=@C,@F??<:>C9EDDCE)B7DB3;D=C>DFD6B@?*=C1?:>>:>9ADFB=+=@B><;E>ADA6@;@@:?*=:0=?FDB<1=16@EAD;:BEC?DCGFBABD@>==91@C=A779??B>?=>;;;FD>6=?FDGBDCEBBFCGA=8<92@DB@CA>BGAE:&G?<:>:A>FEECBE<,8@CDCA(>9F<:>B9E;AACG=BB>?FEEDEC@:BC>>B99C9AE?B=B8AA>;%B?B>6::CG=B??BD3DCFFC<0?9B<;C7@DEBA?<6FED?CD=?CE=D:C86C>=BA+A:CCCC:8==$>F:=9C@?8.4783;:;48<=B:=9=>:>165;>&AAB@59A>9AB>C=B=@?:?@1?B?1C<=<;@6C?3?=<1:?5=A@8CCC<<7:>;B;>?CAC>@??@><=>?<=;6>/9=AA?=7?8A>@ABB=>>A993<;;75A?96&8=?<37-;5A6<@8:A;;:.'9.1.9(8:02,99=>+>:0:@>8;<@0B@?>>@9;24:A>:9<8;8@A.<>?2<;BC5A6@B;C7C9B?7A7?CC8;@<?@@>=8)7<<4=*>:B=:79/=@60:159@<4>A=7=>637:+<@@;<@6<7@9:B:;=A8<:;;0=CA;==;=AB??=;3?==99=:(:9?,AA498??399/5;;;:6;73?B710<=C8A:CBC?=B84?>6>@AAA)C>7BB<1;@18>6>:>>>?>;>6=?4<@<=>94/>=4/55;<@<(=AA(=9==B>?(>7;>9332;>B<<>7><4.=@CA;>@>758/;=8===2@BA=;73ACC6;@0A>B=A?96=??=:<19A=.<<6<=:<:@@:09>B3@A6A5?==2A@/9BB:A6?9C?7B?9@:=A?A>2>:;3?>?8)>2?<299:@??@+??8>?8>438BAA=>?C:><5;66>?.@>=;8=@@/>;BB<C@=:>5>93@@?6BC=>;@?1;7=0558933919)//12,0422109('5906B?=@A6A>@3A:>4<4@AA=>@AA2<9:3@:;?:>9B<84258;%AB==B>>6=A:?/:@:98<>;@=>=?B28>='@=BC>AAA:=>>(5347BCC;8BB?C?C??CA<>5?BB?-7705&36<=>=CC=>@??BAA9@C::@=,<=?>6AB3>99;;89??<2=4=;@=@>==?@6A?6<::=9=7..%53*$*+-430'9).3FEAFDA7:7>@@;<>3<;:>;G6;C8DBBFFA=>;>>5BDGG8>C*BFEE:=8;F8=8AC9>>A7B?1CC0AB@DE;@>CF@4@>CEA@BB?=BCFA9D?D>1?8?A@?=>FB8@2DGDFDGCDBD:) @rCer/185/1600_55_CCS ATGGGGGGGCAACTCTTTTGAATGGAATCGGGCTGATTCATCGCCGGTTCGCAGAGTCAGAACCGCGTCGGGTCTGCGCCGCTGCTGCTGTTGTCTCTGTCTTCACGTCACCGCAGAGGCAAGACAAGGGTCCAGATCGCGGCATCCAGCTCCCGCCCGCCTTCAGGAGAGAAAGAAAAAATAAAATATACTTGGGGAAATTGTGCCTGCCAGAATTAGCAAGAGCTTTCTTTAAGAAGAAATTTGTCAAACTCAACAAATTGAAGGTTAACACCTTAAGAGTTATAGTTATTGACCAGAAATATGGACAGACTTCTTAGACTTGGAGGAGGTATGCCTGGACTAGGCCAGGGGCCACCTACAGATGCTCCTGCAGTGGACACAGCAGAACAAGTCTATATCTCTTCCCTGGCACTGTTAAAAATGTTAAAACATGGCCGTGCTGGAGTTCCAATGGAAGTTATGGGTTTGATGCTTGGAGAATTTGTTGATGATATACCGTCAGAGTGATTGATGTGTTTGCTATGCCACAGTCAGGAACAGGTGTAAGTGTGGAGGCAGTTGATCCAGTGTTCCAAGCTAAAATGTTGGATATGTTGAAGCAGACAGGAAGGCCGGAGATGGTTGTTGGTTGGTATCACAGTCACCCTGGCTTTGGTTGTTGGCTTTCTGGTGTGGATATCAACACTCAGCAGAGCTTTGAAGCCTTGTCGGAGAGAGCTGTGGCAGTGGTTGTGGATCCCATTCAGAGTGTAAAAGGAAAGGTTGTTATTGATGCCTTCAGATTGATCAATGCTAATATGATGGTCTTAGGACATGAACCAAGACAAACAACTTCAAATCTGGGTCACTTAAACAAGCCATCTATCCAGGCATTAATTCATGGACTAAACAGACATTATTACTCCATTACTATTAACTATCGGAAAAATGAACTGGAACAGAAGATGTTGCTAAATTTGCATAAGAAGAGTTGGATGGAAGGTTTGACACTTCAGGACTACAGTGAACACTGTAAACACAATGAATCAGTGGTAAAGAGATGTTAGAATTAGCCAAGAATTACAATAAGGCTGTAGAAGAAGAAGATAAGATGACACCTGAACAGCTGGCAATAAGAATGTTGGCAAGCAGGACCCCAAACGTCATTTGGAGGAACATGTGGATGTACTTATGACCTCAAATATTGTCCAGTGTTTAGCAGCTATGTTGGATACTGTTGTATTTAAATAAAGCAACGAAAAACGCTATTGATGATGCTTTCAGTGTATATTCCTCTGTTGTTCCTAATGCTCAAAATCAAGGGACCTCTGAAGGTGTACTTGGCTAAATGTAAGACATCTGGCATCATCTGCAGCACCGTAACACCTTCAGTCTCAGTTGTGCAATTACTTCTGTTTCTTTAGTCAGGGTCTTTGCAGATTCTAAAGTTATACATGAGTACATCAAAGTGGACAAATTTTGTTAAGATCCCATTTAATATTTGAAAAATCAGTAGCACAAATATATTTTGATTGTTACTTACAAAATAAAATACATTTACAG + KKKKKKKK5KKHKKKKKKKKKFKKKKKJKKK7KKIDKGJKIIKKKKKKKKKKKKKKKKKKKIKKKJKKKKKJKKKKKKKKKKKKKJIKKJK>KKKKKKKJJKEKKKIKKKKHKKKKJKKKK=JKKKKKKJKKKKKKKKKKKKKJFKKKKIKKKBKKK:KKKKKJKKKJJKKJK*KKKKKK2KKKK?KKJKKKCKKKIKK)KKKKKK>KKKKJGKKKKKKKKKIKKKKKKKK;KKJKIKKKBKKKKKKJKKKKKKKKKKKKJKEKKJKBKKKKKJKKIJKEJKKKK@KEKKKK=KFIKKKKKKKIKKKFKKKKKKIJKKKKKKGHH=DKK@IKKJ:IJK@KKK@KJKKKKIKKKKJKKKKKJJIKKKKJK>JKKKKKKAKKIKKKKGKKKDJKKCKK>KH?KKKI3%D>AKIKKKKKJKJKEKBKFKKKKKKJKKKKKKKIKKKKKJKKKKKKKKKKKJKJKKJKKJKKHKKKKKKKKKIKKJKKDKIKDKKKKKK&KKKKKKKKKFJK@KK:KKKKKKKKKKJK?KGKJJJEKKJKEIDEJJK3C7J9F?KKKKKKKKKKKKEKKKHKIKKKKJKKKKKEKKKKKKKKIKJKKKK=KKKKKKKKKKKKKKKFKKKKKKKKKKKKKIKKKKKKKKKKFKKKKKFKBKJKHKKKKDKKIKKKKKKKKHGG/IEFI-KEKJKKJIK3KKJKK9KDKKJJIBKKKKK?KKKIKKJJKKIKKGKIKJKKJKJKKKKJKKI=JKKKKAKKHKKJKKKHKKKKKFIJKKK=KK7KKIJK,IJIA@KKJJKKKK?GKK(KKKKKKKCKJK>KGKKKGKGJKJKKEIKJKKBKKKJKKJKKDIKIJKIKKKKJIJJJJKJKIKKK;KHKCKKKKKKJI(IJAHKK4KCIKGJJJGJIKKK7KKEKIIIIKK7KF?K=KIJEIKGJHJ@KHIKKKKJKKKJKKKKIEGIKIKFKHKKK:KK2GJK3JKKCKKKKKK2KKKIKKBKKJKKJKKKF.IJKKKIKHBK9KDJJKAKIKKGKKBGHJJAKKKIK1KKK@IK*KF7AKKJK=KJIJKHHK7K;KKKKJKIJKEKKKKGKEKJJKIJKJIJJK6JIJKJKJKKKBKGKJKJK@KKKKKKKJKKKKHKGJKKCJIKKKJKKKEFKKKIKKAIKKK?KK=2*;86-765<+<89=7=><*812331&<21-57+$73799:68;;9<79:86'6-01;4;3%7>BA=?B=@847,56;B@@6;>36:=8;>?B>>9=@?>:=(;8<4=><5==44C=5:-=?;?<<27=<>=:>97>4==534<-9-59;6:+%647:75-;1@74<9:.A?+5;5;6<;:;BA:=2>0%>=@;7<=?@A33,,577-37>:'86>9<<88@A@A8<7.6:=<719:5<67/6<;1;67@89=97<7B:?C79::74;7@;?8>22<1548?EA@?*9>;79B::?<@9=BDB0=;2AE==4?A>:9.:864@30=<;FFAF979?88;B2-;7;7=CCE;B@9E7BD=?3<==912&;:75:4929@:73:4:7.>;2)8>>?,AC<58?D8EE?2B@>92BA%>941==+B/<2:?224<95F><>A@A>:;D4=,3631$*8;:?9;093=4@?C170@><4&><;;:7A=6376/<57@C@399><6312;>7;@;5AE/C5>>D&??FA4BBF?C6FBCDFF-AB4@>>CAC8B:EDB?@B@D@C>B3A;8/A@7CF3BB@42BCB988??B@0?88=?2BAE5='>?DC;?6=34;7@416-69)76<4@-9A:99 @rCer/190/1897_63_CCS ATTGGGAGAAAGCGCAGGCGCAGCGGGTTGGGTGGCAGCAGCATCGAGTAGCGGCCGGTTTGCGCAACATCCGCAACAGGTGTAGACAAATCCCGCCTGACTCCGCCCTGGAAAGTCCTTTTGAAGAAATGGCCCTGGTGAGGGCGGCTGGCTGTGGAGACAGAGCTCCATCCTCCGCCGCTGGAAGCGGAACTGGTTTGCCTGTGGCTGGACGGGACCCTGGGATACTACCACGATGAGACAGCTCAGGACGAGGAGGACCGTGTGCTCATCCACTTCAATGTCCGTGACATAAAGATCGGCAAGAGTGCCATGATGTGCAGCCCCAGAGGGCCGGAGCCGAGATGGCCTGCTAACTGTGAACTACGGGAAGGCGGCCGCTGCACCTCTGTGCGGAGACCAGGGATGATGCCCTAGCATGGAAGACAGCGCTGCTGGAGGCAAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCTCTGGCCATGGGCATGCTTGCGGGAGCCGCCACTGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCCTGCTGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTCTTCCTCCTGGACCCCGCCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTCCCCCCACTCCCTACCTCACTCCCACATGGGAAGAAGCTGTCATCCAGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCAGACACCCCCAAATCTGTTATAGGCATTTATGGATACATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGCTTCGAGTTCCGTAGACACGACATGAATCGGCTCTCTGCTCTCTCGTCAGGGAGCTGGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGCAGAGAAGCAAGGCAGGTAGGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGAATTAAATGGGAGTTTCATCTGGCCTGGGTGGAGGCCAGGATCAGACCATGGTGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGAGATGTGAACGTTCCCTGGAGGGAAGTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATACGTCCATACCCAAAACCCCTGCCCACAACCAGCTTCTGGCTGGTACCCATGATAATAATTGAGCTGAACCTTGGGCCCTCGTTGGGGAACAGGTGATTCTATTTGAGACTTCTAGCCCAGAAAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACCTTTACACCAGCCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCTTTCTATCCCAATCACCAACAGAATGCTAACATCCCTGCCTGTAGCCAGACTAGCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAAAAAGATTTGGTTG + %##)(''&((%((()()(&'%$(&%'%)%()&%&(('(''$$((()&''%#$&$$$&$,,$#"(+'(*'+*,(&+&,,'&,,,+((,'$')01).0--,5.21&136425/.-%/-2-152+31&154*51*52*-2541//4&41+25603).01*,*/0+4.4555.455+56110(%,56466522,3-0-3060012$/015/43322566,15)..0+(-1,50$4-26512054.11+-/0061554/3,,..,**)*+))340/0623/1%,0&/-),+.32/15/14)02254)$.1562422/-./41,1.+1**.(#,-*-2,,.-,302/4+02,6++).*,(&&0-,%-*%"$*/15/3(0.00%,&('0,)(+&*-&+/..1*./)-()&)#)$)'((')(*/-.//+.,,./34001///*522462.54.531,((/-%/,1'1113510264121,36/6103.42242.0,1)+../../2.0.*4/)+*231134)45///3224005553+04651/4/.'-60/34/1-23/562.20/2-1//1+4505313/*2502441,&44+,5*)$.1413/'0-,,%0+2061*)/26/3&5565+-0-3/3101621126534)2.0-0'3515644.2(+441*(51,02112,5.0/1141)5425564662/03&3312,-*11-4430562+0/-.-642/4656/2.4-%11#/013/405/104331()#(0/,52*51/22,+54.31001-136-55064/'%(0,-124/&0%.0,5/+516543'31+4+0333+./..,0(3.(-4(+,50,14.152(0.14/.*-(*2*2)+0454('$+#.&/55/55.254/*-3)/155/4)464,3350.$.53401343(54*0403-003***0--..-.20/-1.*,-.,*,'.43,-)1+4/114*54./205202/540062-304,%-50111/,-1)422143353102300'0.5#0/-/3434,*4110,24022+1342630/*,&.2/&*($(*,*+01*-')/36155*43221/153/,)3.32260246/1-51/44+4/225+166.213/,1121'-&&/2-'3560652+)%/-11540,3.(%.1400*('*3+-0),.44).).2./(..))%..0045003*5514,+-%))*)/(/30-*-.*-'(.0-/+)*#0*/)-.1/1*1)/5)0/-)-/.*.+/,)/'))1.52.+)-40.%+(/2.0./41%0*44*/0$'*+45523)-14/04/561-13,10-1)2-/014-5532+)00-*,0))3/56+5//4/$..3324/511/3/0.1+-1++/.5406+),'.+)0455'&/3*-%3*46,$1610141154/*01/*-*&(+)+'44+521.*1,1/11&4/%,-/1+'..$2/05,(.1#%&0104-(+3.0+*.20))32&135462-02-+'.-+)//)0.-3)45,10/(201/.*/40,&&*0/(,))#),/$.1-/*,1+*-**00,*.3.('&.54255,.3.2240/1*-'/*--*-..-)'#%/22.-/.433&)2-0/+.'%,#63).)43/(+,0'*,(/-/-+.*'',./,--.1'0*010-10*0122/11/1-01*).,+,**-//(110$/+'1/.,(&%-)-'(%----+%*/.*220111122-0(/,,--.,,)%*$00-*-,,)011)100-/,01--+'$*)1,'0&//.+1,1-//-&0/*,+$(*+)()*&)*00+**0(-*--*&((')--+(%"'*&#%#%%)',(+ @rCer/191/555_87_CCS TGTTACCACAAGTCTTTTTCAATTTCTCAATATTATGAGAACTTAGATGTATCTGTTTAGTTTCCTGTCTAAGAAAAGGTTTAACAGATCAAATGTTTCAATAAGTTGTATAAACAACCAAGAAAGTAACAAAAATGAAAAGAAGATAATTAAATAAAAAGATAAAATCTATCAATATGGGCCTGGGGCGGGATAACAACATTATATCACAGCCATTTGCAGGCTGATGGCGATGAATCACTTTATTAGCCGGGAGTTCAACCAGTCTGCGCGACAGTGGGAAACTCCCGTCTCTACTTAAAATACATAAGTTTAGCGCTGGCGTGGTGGTATGGGCGCCTATGTAATTCCAGCTAGCGGGGGGGCAGATGCAGAATTGCTTAAAAACCTGGGAAGTGGAGTGTTCAGTGCCGGGATCGCATCACTGGCTCCAACCTGAGGTGAAAGATGAGGACTCAATCTAAAAAT + '+"',*+--)$+)$(')*)--&$*##**&--,#$+-&,&'+-))."'/(%$,$+#%$'.-.%"-+&-*-,-$#+%#,"'"+(.%-.'%--,*--.#*',..-'++'#(**%-%&-',-+$,-#(+,*,%#$,*',.+$%#*",(&+"+$.(-)$,-(+*+,."(#'&-+'#+,&&)#'#)$(*#*&"&%'"##&*+,+&.".**%)/*%*+,"'#)%%#&)")(,--",'+*&,&"*.,,'.((-"#-.*/-)%+,"(-#+(,...#-/+-*.-'&##%$(+#+,")*+-.#'"-.+",&-,...--"*-,"%%**%"$-()&+(#'-+&-##-*&.,&)#".#+-'.*.+-...&"%"#'%#('%,..",$.*,+-$-(-)'%*#+,".+)&$&(.-'')$+.(+-.-+)%'*)+,--**/-*,..%*'-*++*'-#",(../#*,(/..,'))/..,.*.)*(('# @rCer/192/25_2051_CCS ATGGGTTCCGGTGCCTGCAGAGCTCGGAGCGGCGGAGGCACCGACCGAGGCTGCACCGGCAGAGGCTGCAGGGCGGACGCGCGGGCCGGCGCAGCCATGGTGAAGATTAGCTTCCAGCCCGCCGTGGCTGGCGTCAAGGGCGACAAGGCTGACAAGGCGTCGGCGTCGGCCCCGGCGCCGGCCTCGGCCACCGAGATCCTGCTGACGCCGGCTAGGGAGGAGCAGCCCCACAACATCGATCCAAGAGGGGGGTTCGGTGGGCGGTGTGTGCTACCTGTCAATGGCATGGTCGTGCTGCTCATGGGCCTGGTGTTCGCCTCCGTCTACATCTACAGATACTTCTTCCTTGCGCAGCTGGCCCGAGATAACTTCTTCCGCTGTGGTGTGCTGTATGAGGACTCCCTGTCCTCCCAGGTCCGGACTCAGATGGAGCTGGAAGAGGACGTGAAAATCTACCTCGACGAGAACTACGAGCGCATCAATGTGCCTGTGCCCAGTTTGGTGGCGGTGATCCTGCAGACATCATCCATGACTTCCAGCGGGGTCTGACCGCATACCATGACATCTCCCTGGACAAGTGCTACGTCATCGAGCTCAACACCACCATCGTGCTGCCCCCTCGCAACTTCTGGGAGCTCCTCATGAACGTGAAGAGAGGGACCTACCTCCCACAGACGTACATCATCCAGGAGGAGATGGTGGTCACAGAGCACGTCAGTGACAAGGAGGCCCTGGGGTCCTTCATCTACCACCTGTGCAACGGGAAAGACACCTACCGGCTCCGGCGCCGGGCAACGCGGAGGCGGATCAACAAGCGAGGGCCAAGAACTGCAACGCCATCCGCCACTTCGAGAACACCTTCGTGGTGGAGACGCTCATCTGTGGGTGGTGTGAGGCCCCCCTCACCCAGAACCCCCTGCCGTCTTCCTCTTTTCTTATTTCCGGCCACTCTCTGGCCCTCCTCCTTCCCCCTGCTTAGCTTGTACTTTGGACGCGTTTCTGTAGAGGTGACATGTCTCTCCATTCCTCTGCAACCCTGCCTGCCTCCCTGTACCAGAGCCGTGATCTCTCTGGGGGCCCCATCTCTGCTGACCTCCTGGGTGTGGCGGAGGGAGAGGGATGCCACAAAATGTTTCTGTGTCCCACTGTCTTGAAGCTGGGCCTGCCAAAGCCTGGGCCCACAGTTGCACTGACAGCCCAAGGGGAAGGACCAGTTGGGGGAGCTGCGCATGTGAGGCCCTGGGCAAGGGGTAGGGCTAGGGGTGCGGCATGGGCTTCAGAATATCTGCACAATTAGAAAGGTCCCCAAAAGCTTTTCCTTGGAGGGTACACTTTCTTCACTGTCCCTATTCCTAGACCTGGGCTTGAGCTGAGGATGGACCACGTGCCCAGGGATGGACCCACCAGAGCACAAGGGAAGGTGACTGCCTGGGGTGTCCCGGGACTCCTGTCAGTGCCTTCAGCCCACCAGCAGGAGCCTGGAGTTTGGGGAGTGGGGATGAGTCTGTCAAGCACAATTGTTCTCTTGAGTGGAACCAAAGAAGCAAGGAGCTAGGACCCCCAGTCCTGCGCCCAGGAGCACAAGCAGGGTCCCCGCAGCCAAGGCAGTGGGATGGGCTGCTGAGGAACGGGGCAGGCAAGGTCACTGCTCAGTCATGTCCACGGGCAACGAGCCGTGGGTTCTGCTGAGTAGGTGGAGCTCGTTGCTTTCTCCAAGCTTGGAACTGTTTTGAAAGATAACACGAGGGAAAGGGAGAGCCACCTGGTACTTGTCCACCCTGCCTCCTCTGTTCTGAAATTCCATCCCCCTCAGCTTAGGGAATGCACCTGTTTCCCTTTCCTCCTCACTTTTGCATGTTTTTACTGATCATTCGATATGCTAACCGTTCTCAGCCCTGAGCCTTGGAGAGGAGGGCTGTAATACCTCCAGTCAGTCTCTGGGATGAAACTCTTAAATGCTTTGTATATTTTCTCAATTAGATGTCTTTTCAGAAGTGTCTGTAGAACAATAAAAATCTTTTACTTC + D>)CFEHKGH;JJH5ED>EKJ<>IIFJJ=J9KKKJJKAIJKEGDEHEKIKHFIIEHHJ?F@K4KJJDJ@HF/JIH2HFHEEB>HIK8KFA:;JIA%J><;+JJKIFJHB:IIABC$EFIK=CKBD=JIKBKFFKGHKGGGIJGGIJEBAHHHHHAEIIK=CKKJJIJJIEHCJKJJJFG;E/FKF?F?GGJAE?@FBCA9CGJ?AKIK9IIGE?IGCFG*HD?HKI8IG>G?KHEHHEIKGBFF@EH9IBKG>9FGJFGEEKJJCDJIKGJIIIKFJF5@GEHJEBCIFIBHF?CHIDKKGHJFJFDCAH$C9>>BFEFAKJIKICHDG@GDIKIFJGGKGB9KFFHHIDJHIKIFI@KGJI.7CEIFCFIIFBC@>I?E?$@999ICBHID=I+JKKKHF6KKKJ:KFIHJHGHGHF>:JJFHJ;KHDEGHI9KJIG;HJ8KIIJK.KDDCIH2KK'KIFFEF6FEGJ>FKGBIE0>6FCG?JH:IG'EGI8IKJII)JJKGK4I7EA&BBC@DE=%G@C@FE>KFHFGH+HKJ0KKH;0KG+IIIHK?6HKGAHIJKIBEHBE@A@GIEKJCFJ;E:CE;@CFF=I>?HEAJEI?:6@>;B?7FHDHGHEAHHI;@$EC>?JFDD>D8>FEI>HHDAFEHFHGDBH8?1:3BD'CA>>B9:@E,<7JE*HEEBDBJE?A1FFDAA<;EDAFIH?=7C@@H?G.JJF1HEI7=?GIH1IBE>JHIAC5E8AE7GA@DE>E'DFB6H60GAFI?DF7E?A?D6H@AHBJJEI8EGE8GJGJHIFC@BEC*BCAHD?E?EIIB1BB7HI1GJDIBDJIIIF3JJGCBFIG3IHHIGEIIHFII>HEGEGI?=@IAJCI??H@A?875EHIGIDFIDH.EBGA4G4'?CA>??IJD;H9G(FDABGDCA-?;-EC@DD+AEGGCE(HDEFI:JI @rCer/193/1857_55_CCS ATGGGGACCGCCGAGGACCGCGTCCGCCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCCGGTGACGGGGTCACCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGAGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTTCCAAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACAGTGCTGTCCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATTCATTGCTCCTCCTGAGCCGCAAACTCCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGGACGAGTCTGGCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAACAAGATGAGAATATGGCATGGCTTTATTTGTTTTTTTTGTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCTCCTAAAAGCCACCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACAC + .*01.,./,*1*/,,&,.'+'.+.'*('')#011.,1,110,*')&()0($)$$'('.*,&.2/1/,/(/20.++,,-%%0*+-,%'%)),)&**-&,$(11/+/**&&())(.()',,'-00-.+('#.2,+,1'-*$)+,,.*-%.-((,***$(,+00,-.+/*.'&%%(*$-/(+,*--))+.-')0*./1-/010%)/.0-*%-%+/0*,,/%*/(.++)#)&-$)('//++*-(0--$'(,.11/,/10/,//0)*//)0(+',-,,,,'.,)*(+(,.(+.01..,.(*-*)*),&,245150/.0(/+-/4463340)./2-**'&&+,,*,+,&*,*.0+430.601.+1144221//*00.+-/-/0+&/22.-)3-5-03.5111431%*-,1433/-4246-0/0111*,,'/-342*,'4$,+%',+'**-))%%((,)%)+-,.(&&*/.-.&.,-+0'/,+0*-/),0..12/,,.,,&+0,*,**+-/.2/+.,)/,&//...+0-1/*/*(.(//,,***()*()/%*(&'.,(,12,'//*+%.-+00.0,/'(('+$+--'')&'-2-'#%%,,+,()(%##&').'.++*)%+,--)'&''----++')**-*+,%)(,++*'')%00).,-/-0))+/.'0//-/2.,.*.,.,+*'-,--*.*'(),0--'-,-0+**,&(+-,0-,/-/0(-/*,+--)(,-,*(-/0('.$0,/+1).+*.%*++.,/-,-(-0+&*%/2./-0,/++&/'(%-*1,.*,&,1.)-%&&)/012/-,-(1.-,/*(-,/+0)1000-0,+)$)&/--+1,0.-//0,0/'%+1*.-,.'.,/0+0+././)+02/-*-010+),,**#1-*+'+*1&/,/0++,//)(',-(($&+(+*(.&'&00-'.0/.)0.02/.+*,&+(*$#,+&)0-+*.110/.,(-&,*((0*/)+*%''/,'00.,))&)((%/*0.10-''-0++2-/)+)'+'%,-,*/+*+/()(($.(*+++-0/*(,&(12..,1.%+&#...*%&+00-(++''-,'*-'(+-*)(,+-*+)%#*+'''(),%(,&,)$'#",(%"'%"&%$%(+))'+)*)'&)+*).+(%(*+,)*(,(+),(()#''*'()-(','-*&&*'-)-)+,+-.---+)&&,)())&%&'$$()-*))$%%*&)+*-(,%'+*--))(+'('&++(,++()-,*$#+,-+))(,,),-*'$&)'(*%)*$*+()&#$#%$%&)*+,.,--+&+(*,#$)')'&*+''%&#$,',++(%&-.,+)(%&)+,,,,,#%*+$,1.2-*,-/.0.0-1',*)(&/-.,,/+,)*(%*/,$)/2.)&,*-.$,-/***/1.0-/1.12-2..(-,/*-++*%)/11'/.,,2.,+/,-11112+0*&(,,,,+.++*+,0,.-/.&+(%,.../-.,#,).+-,)0/)1.'0*+))++-')(.'.0./*(/.0.2+*..,'01+1%+2,/022,.1*+/,%.-+**&*-0*/.-,1/,'-/)1-*,/),-0/+.*('.002,0+/012201-,'&/.*(1.,.*,1/01..)#0,--%.(,.&)*(*.,,,,$,.,-,/$,)(/21110,0+)*.,-+-,+)&+./)%#$-0#%.--++.,,&'()+./(,#,*+./1--*0-/.,0*/(*,-*&/)./+1.101/0+-,2..0+//-%0).,+/0)+11*),/*/-*,-,2/01,--00+%%(%,+//+-0-*-/-0121,)%+,+,-2001,0/1,),/111./. @rCer/195/0_775_CCS GTGGGCTTCAATGTCAAGAATGTTGGTCTGTCAAGGATGTTCGTCGTGGCAACGTTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCCAGGCCAAATAAGTGCTGGCTTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGGAGCAGTTGCGGTTGGGTGTCATCAAAGCAGTGGACAAGAAGGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAAGATACCTGCCACCCCACTCTTAATCAGTGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTATAAGTTTAGTTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGAGAAGAATGTTTTGTGACCACTTTGGTTTTCTCTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTTAAAATCAGTACTTTTTTAATGGAAACAACTTGAGCCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTTAATG + S(%))#%('$&&(('"#"$'++%))))'(+*&*-,.-+-*-)*,+,-+-((''($++*(,+.)++-+-,%+&*+*+)',,)'*'(+&,)-+-***((,))++&&*+,+,+**-+$',-,/./,)/+1.0$+))*)'(,,./'/00-1-,21%-.*,-2201)+111.())0-,1.++),((-0/,-*00+(-1+'10)-/..%+1**/1.2/.$*)''+0-+'.002-/2(',01.20,.201*../%&**+)0.,%--+1-10/%.(,/,-0)**,%*,0+0,++&'-,+,-())'*).,)-,%)$$**)+.&,..(.+-*%(&%+'',)-//.-+$(+-,-.1'+-.01/$/,..*/,1(%&(,.,()$$&&'%&%%%,*.,%$((#")./,,/*0*%),+0/1/1,/,&'-))-$('*/.'+.,**,+%&('-+/.-+%)&,-,(+'$),,+$+'('*,(*%(&'###$%&+$&'*+,+(%'%)'%%)(+&($*+-(()(++,)(,..+$#(%&$-.,((&*/.&+)(+.,/+0+,,$'()*)0+)/),.0-21'(0%&,,+#(&'($%//-*1-./-+%%*%.,-*.,.'&#$%)++,(+'$*1*-*+)+,'((.%)(,1*$*&+,/./0,-*,,,*,..&-)(-)/*/00'*"%)//,..,000(-,*(&-.,'*0*+%**&($%*')$#'('*&(+&&%&(+(,*&*+(*)+,+)(+&,''$((#)'')().+&')'*&%%"('(')*&#&$&$&$++&&**#)'**++ @rCer/197/0_2302_CCS CTCCGCTGCGCGTGGATTTCTGCTGCAGAACGGATAGCCATGGCCAACCAGCACAGGGTGCAAATACCGGGCTCCATCCTGACTTCCCAGCTTTGCCCCAACCAGGATGCTGAGGCTCGTACACTGCATGAAGGCTTGGCAGTGACAAGGAGGCATACTGACATAATCACCTCCGGACAACAGCAGATGGCAGGGAATCTGTCAGAGCTACAAGTCCCTCTACGGCAAGGACCTTCATTGCTGATTTAAAGTATGAATTGACGGGCAAGTTTGAACGCTGATTGTGGCCTGATGAGACCACCTGCCTATTGTGATGCCAAAGAAATTAAAGATGCCATCTCGGGCATGGCACTGATGAAAAGTTCTCATTGAGATCTTGGCTTCCCGACCAATGAGCAGATGCACCAGCTGGTGGCAGCATACAAGATGCCTACGAGCGGGACCTGGAGCTGACATCATCGGCGACACCTCTGGCCCTTCCAGAGATGCTTTGGTCCTGCTCCAGGAACCAGGGAGGAGGATGATGTAGTGAGCGAGGATCTGGTACAACAGGATTCCAGACCTATACGAGCAGGGGAACTGAAATGGGGAACAGATGAAGCCAGTTCATTTACACTTGGAAATCGCAGCAAGCAGCATCTTCGGTTGGTGTTCGATGAGTATCTGAAGACCACAGGGAAGCCGATCGAAGCAGCATCCGAGGGAGCTGTCTGGGGACTTTGAGAAGCTGATGCTGGCCGTAGTGAAATGTATCGGAGCACCCCGAATATTTTGCTGAAAGGCTCTTCAAGGCTATGAAGGGCCTGGGGACTCGGGACAACACCTCATCCGCATCATGGTCTCCCGTAGTGAGCTGGACATGCTTGACATTCGGAGATCTTCCGGACCAAGTATGAGAAGCCCTCTACAGCAATGATCAAGAATGACACCTCTGGCGAGTACAAGAAGTCTCTACTGAAGCTGTGTGGGGAGATGATGATGCTGCTGGCCAGTTCTTCCCGGAGCAGCGCAGGTGGCCTATCAGATGTGGGAACTTAGTGCAGTGGCCGAGTAGAGCTGAAGGGAACTGTGCGCCCAGCCAATGACTTCAACCTGATGCAGATGCCAAGCGCTGCGGAAAGCCATGAAGGGACTCGGGACTGACGAAGATACAATCATCGATATCATCACACACCGCAGCAATGCCCAGCGGCAGCAGATCCGGCAGACCTTCAAGTCTCACTTTGGCCGGGACTAATGAGTGACCTGAATCTGAGATCTCTGGAGACCTGGCAGGCTGATCTGGGGCTCATGATGCCACCGGCCCATTACGATGCCAAGCAGTTGAAGAAGCCATGGAGGGAGCCGGCACAGATGAAAAGGCTCTTATTGAAATCCTGGCCACTCGGACCAATGCCGAAATTCGGGCCATCAATGAGGCCTATAAGGAGACTATCACAAGTCCCTGGAGGATGCTCTGAGCTCAGACACATCCGGCCACTTCAGGAGGATCCTCATTCTCTGCCACGGGAATCGTGAGGAGGAGGAGAAAACCTGGACAGGCACGGGAAGATGCCCAGGTGGCTGCTGAGATCTTGGAAATAGCAGACACACCCAGCGGAGACAAAACTTCCTTGGAGACACGGTTCATGACGATCCTGTGTACCCGGACTATCGCACCTCCGGAGAGCTTCCAGAGTTCATCAAGATGACCAACTATGACGTGGAGCACACCAACAAGAAGGAGATGTCTGGGGATGTCAGGACGCATTCGTGGCATTGTTCAAAGTGTCAAGAACAAACCCTCTTCTTTGCCGACAAACTTACAATCCATGAAGGGTGCTGGCACAGATAGAAGACTCTCACCAGGATCATGGTCTCCCGCAGTGAGATTTGACCTGCCAACATCGGCGGGAATTCATTGAGAATACGACAAGTCTCTCCACCAACCATTGAGGTGACACTCCGGAGACTTCCTGAAGGCCTTGCTGCTCTCTGTGGTGGCGAGGACTAGGGCCACAGCTTGGTGGCACCTCTGCCAAGAAATGTCATCAGCACAGCCGCCACGGCCAGCCTGATTGTTCAGCTCCAGAGACTAAGAAGGGCAGGGTGGGAGGGTTGAGGTTGGGCTCTTATCTTCAGTGGAGCTAGGAGAGGCTCCACTCCCACGGGCATCGAAGGCCAGCACGACGAGCGACTGAAAACCGTAGCATAGATCCTGTCCACCTCCACTCCCTCTGACTCTCAGCTTCCAGCTCCTCCCCTTGCTACAGCCTCTGCCTGGTTTGGCTATGTCAGATCCAAAACATCCTGAACTCTGTCG 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@rCer/201/1659_58_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACACTTTCTTTGACCCCGTTGGGGGGAGATCCTATCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTT 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rCer/204/2657_63_CCS ATGGGGGGGGCGCGGGCGATTTGTAGGTAATGGCGGGCGTTCGGGCCCTGAGGTGCAGCAGAGGATGCGCTGGCGGCTGTGAGTGCGGCGACAAGGGCAAGGGCAGCGACTCCTCGCTGTTGGGCAAGAGGACTCTCCGAAGACTCGAGCCGCCACCAGCTGCTGCAGAAAGTGGGCGAGCATGTGGAGCTCCGTGAGCGAAGACGCGTCGGTGGCCGACACGGAGAAGGCGCGGCTCGAGGGAGGCGGGGGGCTGCGGAGGAGAGGCCCGCTGGTGTTCCTGTGCTGCCGGCTGCGGCGGCCCGCTGGGCGACTCGCTGAGCTGGGTGGCCAGCCAGGAGGACACCCAACTGCATCCTGCTGCGCTGTCAGTTGGGTCGAGCCGGGCATGGGGGCGTGGGGTCGCCTTCTTCAGGTTGTGCCGCGCCGGGGCGGCCCCGGAGGGGGCCGGGGGCCCTTTGGCGCTGTTCCAGGGACTTTGAGAGCAAAAAGTCTGAGAGTGTGAGCTGTCGCAGGAAAAGGGGAGGAGGGTCACCCCTCCACCTTTGGTTCTCGGGCGACTGGTTCTGTTCTGGGCTCCCCCGATCCCAGAAGAGCACGGGTTGAGTCAGCATCATCGTGAGCATTTACTCAGAAGCAAAGGCAACAAAGAATAACACTTTTAAAGACCCTAAAAAAAAAAGAGAAACAAATGGTCAACTAGACCGTAAGCACTTGAGGTGCAGCCAGTACTATTACTCCCCACAGAAATTAGCGGGCTGGTGTATCAGCGGATACCTCTACAGTCTCCAGTGATAGGGGCCGCGGAGCTGACGGAACACAGTGCTATGGGGAAGAAAGGGAAGGAAATTTGCCGTAAAAGCACCACCAACCTCATCAAAAAATTGGCGGAGGAAGGAGGACGTAGCAAAAAGAGTTCAGAAGGTGTTTCCTGTAATGTTTCTGTGGATAAGGAACAGAAGTTATCCAAACGTGAAAAGGAAAATGGTTGCATCCTGGGAGACTTTGTACTGTGCAGGGTGCTCGCTCAATCTTGGCTACGTGTACAGATGCACGCCCAAGAATCTTGATTACAAGAGAGACTTGTTTTGCCTCAGTGTTGAAGCCATTGAAAGGTAAGTTTGATATATAAATGTTTACCTCACAACTGGTGTTTCAGAAAGTTAAGTTTGCAGAGAAATTGGCACGGAAGTGTCCGAACTAAATCAATACTGTTTGGTTAAATATATTTTCAAGTAATGATTTTCTAACAAAGCCAGTAATTTTTTTTTTTTTTTTTTTTTTGCTTTGACCTGCTTCTTTATTTGGTATTGGAAAAAGTCAGACACTCTAAATTGTAGGAGAAAACACTGTGAGAAATTTTTTGGAAATAAAAGTATATTCAGTTGTTTTTAAAAAATTGAATTGTAGTTTAGGTAGGATTTTGCCCACCGCCCCTAGCTTTTTATTTTATTTCTTTTAAAACTTATTTTTTTAAGATATGGGGTCTCACTCTGTCACCCAGGCTGGAGTGGCAATGCTGTGGTCATAGCTTTCTGTGTCCTTGAACTCCTGGGCTCCAGCAATCCTCTTGCGTCAGCCTCCCCAGGCAGCTAAGACAACAGGCGTATTGCCTGGGGTCTTGTGTTGCCCAGGCTGGTTTCAAACTCCTAGCCTCAGATGATCCTTCTGTCTCAGCCTCCTGAATAGCTGGGAACAAGTGCATGCCACCACACCAGGCTTGTATTTTTACCTTGTACCATACGTCAGTTATGTTTTTTAGGGTCCTCTGAAAAGCAAATTTGTGTCAGAAGATAAAGAGCTTTTTAAATCTTGAAAGCCAGAGTTGAAATAGAAAAGTCTCTAAACACAGGTAATTTTATTCTGTACGTTTTGTATCTCTGTATGAACAATTTGTCAGTGAAGAAGTGCTTCCCCCACAAACGATATTCTCATAACGTCATCTGTCTTGATCGCAGAAGAGTGTGCCTGTTTCATTTCAGGTGTTAGTAAAGTTGATTTTTGGGGAACTCAAATGAAGCTAAAGCTTAATTCAACAAAATATAAGACATTTCATGACAAAATCAAAACTATGTATTCTAATTTTGCTAAGTAAGAAATACTCTTTGATTCAAATCAGTATTTTGTTTGCTTCGATTCTTTGTGGTATAAATAGCCTTGTTGTTGGATGTTAACATTTTGTCATGGCCAGAATAGGTGAGATGGTGATGATTGTATAAAAGAGTGCAGATTGTAGGTTGAGAACTATGTTGATAGAATTATGCTTTATTTTAAAAATTTATGCCTGCAAATAGTTTTGGTAAAACACTGAATATCTACCATGTAATGTATGACATATCCAAATTGCATTAAGTGTATATCTTAATTATTTTTAACCATGTATAATTTAAATGATATGTGTGTTTAATTTTTATTTTTCAATTCAATAGAATGGAAGATGTCTTGAAAGCATTACAAATGAAGCTGTGGGAAGGCCGAATCAAAATGTCCTTTTGCCACTTGTAAAAGCTGAACTCTAGTCTGTGTCCTCCATTCTGCCCCCGCCCTTCCTCCCCTTATTTGTTAAATGAAGCACATAGTGAGACGTCGTCTCT 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@rCer/205/1801_60_CCS ATGGGGAGTCCGAGACGGTATGGCTGCGGCACTTCGGCCCTCGAGTCGAGTTCTCCTGCAGGCATCGCAGATTTCGATGTATCCTGGGTGGGAGGCTCCGGCTCCGTCAGCTGCCGCTGCCCTCTCGGAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATAAAAGAATTTCAGCAAAAGAAAGTGGCTGTTGCATGCAGTCTTCCTGGCACTAAAGAAACCTATTTAGAACTTGAAAGAGAAGCTGACCCAGAACAAGCTCATCTTGAAGGAGGAGTTGATAACCTTACTTCATTTGTGTGAGTCCCGGGACCACGTGGAGCTGGCTAAAGATGTCATTTACAGGTACCATGCAGAGAACAAAAATATCACTTTGGGGGTATAAGTTTGGACCGCTTTTTTGTGAGGCTGTGTACGAGTTGGATCTCGACGAATCGCAGTGGAGTTCTTGAAAGACCAGCATTACGAGGTTTCTTCTCAGACTCCACATCATTCAATATTTTGATGGACATGTTATTTATCAAAGGCAAATATGAAAAGTGCTTGGAAGTATTGATAGAGATGAAAACCAAGATGTGAAGTTCACGAAAGATACCTATGTTCTTGCTTTGCAATTTGCTACAAACGAATAGCCTGAGTCTTCAAAATCTGTACTACATTAAGAGAAGAGCTCTACTCAAAGGAGAAATTCTCTCCAGGAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGATCAGAATGAGTTGGCAAAAGCTGTGTCCATTTTTCTCAAATCATGAATCCAGAAAGCATAGCCTGCACTAATTTAAATGTATAATCCATATCCAGTCAAATGCATTGGAAACCTGATAGAGACTCTAACAAATGCTGCGGAAGGAAATTTATCAAATTTGTGAAAAGACATATGTTCTCAGAGGAAGTGCTGGCCAAAGTGAGAGAAAAGTGAAGGATGTGCCTGCCCTGTGGCCAAATTTGATGAGATCTATGGGAAACTACACATCAGTGGCCAGGTCACCAATTATTCTTTGGATGCTGTGCTCTGCTACACCCCAGGGACAAGAAATCCCACACATGCTGTTAAACAAGAGGATGGTCAGCCGTCGCACCTTCCGGCCACTCAACCAGTCCCTGTTGGCTGAGTAACCTGGTTTCAGTCCACCTATGGATCTGAGGGGCCTGCTTCTAGTGAGTTATTGCCTTTCCTAAGAAGTCAGGCATCGCACTTCAGCAGACACTGTACTGACACTTGGTCTCCTCCTGAAATTCCCAGATTCACTGAATGGTACCATGCCGACCTGTGAGAAGTTATGTTGCATCACTGTGAGGTCTAGATGCAAGCTTGGCTCCCTCAGAAAGGCGCTTCCCTTTGCACTGCTGAGGATCTTTGAAGGAACATGGTCAGTCTCCAGTTCAGCTTCTGGCACCAGAGTGGAACCCAGTAAGCACCATCAGGAATGAATTTCACTACAACTGTGGACAACTCTGATTTTCAAGGGAGTAGTTAACTTGCAAATTACATCCTTGCTGAATTCAGGAGGTCTAAAACCCTACTCTACCATGTTAGAAAACAGCCCAGGATTTTCTCATTGCTCTGCCATCATATATATCTATGACTAGAGCCCTCATTTTTCCATCTGCAAAACATAATGCCTATGTGTATTTGCATATAGATTTGAAATCTTCATTCAAGGTTCGGTAGGATCAGATTTTCTCAAAATAAGATAAATAAGGTTCAT + 31046%;945+6329=<57//?;599<9-:<1:9<=4;;-6<>38<:858>47+<4778792;9>=;=::;65+=;9:8;63?;359'5,3%+7)59;<=93:?7<836868:>8=4+8;6:88)636>?>:<8:069;;<2;26:94:>=:6.$*:;177,68)<8979<<(;>=,3232;966(:3*3;:7+.494701;127=;903<99.8./244%.48#79-5==675291>:7<=?;256903;2:=745;3=9:94?=/82;9<,:49>.>;7,7;<2=>;;19561743483-<:,49-,;=4=<6:;99375:2'3,325=8??:4+0><38?4<6;>:;>=;;==;::'07078<9:2643&)9-.:3<7:9<43:6>5329;7%9971<241620*625,6786/67664<3>9<0:$49:/%,**-3.08.7743716243448%-426;824$-5),25/76667778983:5.35+3535/+6547546,-45/::80157::5:2887,2304433&7/948&127.331,%3955::7648865&2.6-43'+-/6+6;:841367-60079537,39555(5555$+78-::47'384691%38580/6%.484110'0356'7/,--1536:6655&2/14+,)8868,231764'935814&3.40027,850653166/666664-56844.:4048/58:1100#(6%06-,4499.9-4653+9:591737-04507$/3777&1/,196/5923554,4141/5;7.547436*74089414+(&/023*40++81242.58076842'/-14$04124-65.76843-9528945560499/8*:643(7/*+-343$'7*777520'759997'-4*268*032/53655300,5+85-8767271476$628787052-898.4:7651-3768155&*1(2:56,60*.41,/5(863826763/,7,5:7:;847217676436/540:998554319/3/6769.573880667*+6;59:95843(44-'39522)77599398,0.&438/3,625:2-50666:75:346;38&7/9,5960;6385;;9:85*:56448976.2#)3+65-5.749.4:::7797558:99228'50236;5403979:51/5+*69656/6.63467442-3117872741.-&,491324:7:.7/354041(33*2+,65656545::936499,/.+.'14-99954:7414)-29;488/5:77/,37+6572:9815-+26.74:90#234848:55744.3294:30475.49:986*589443/40/03.5206-9:7246/6.676*14+--2(027;3,&046446233516/36:0:63(91505&(38:4/%4.+4435170,44558:;597176.47*:1::9716::567,097.3)---.025)531490072345(42.9.6964':49922:4628748;51.6:;697&5137370:;6(77466+/(-89727.403)6488852;6.148+64:78454&68-4%19424.,)3+316,352/21/.372*)&(5:98):877645421(%,%/54329151584825-/+4/'-/)52977(97759297:56'88-:880.85958+,.815+066+98869:06:3854632395;73'424 @rCer/206/25_1554_CCS ATGGGGGAAGCTCGGCTGATTCTCGGCTCACGCGGGAGGGGAGTAAAGGGTGGCGTTCCGGGGCTGGAGTTCGGTGGGTGCAGCCTGCTTGCGAGCTGAGGCAGCCAGTGGGGCACCTGCGGACGGAAAAGAAAGGTTGATTACAAACAGGACCATATTTTGCTTCGAAATGGAACCAGCAGTTAGCGAGCCAATGAGAGACCAAGTCGCATGGACTCATTTGACAGAGGACACTCCCAAAGCGAGTGCTGACATAGAAAGGTTAACCAGAATCAGGCCAAGAAATGCACAGTGATCGGGGGCTCTGGATTCCTGGGGCAGCACATGGTGGAGCAGTTGCTGGCAAGAGGATATGCTGTCAATGTATTTGATATCCAGCAAGGGTTTGATAATCCCCAGGTGCAATTCTTTCTGGGTGACCTCTGCAGCCGGCAGGATCTGTACCCAGCTCTGAAAGGTGTAAACACAGTTTTCCACTGTGCATCACCCCCAGCATCCAGTAACAACAAGGAACTCTTTTATAGAGTGAATTACTTTGGCACCAAGAATGTCATTGAAACTTGCAAAGAGGCTGGGGTTCAGAAACTCATTTTAACCAGCAGTGCCAGTGTCATCTTTGAGGGCGTCGATATCAAGAATGGAACTGAAGACCTTCCCTATGCCATGAAACCCATTGACTACTACACAGAGACTAAGATCTTACAGGAGAAGGCAGTCCTGGCGCCAACGATCCTGAGAAGAATTTCTTAACCACAGCCATCCGCCCTCATGGCATTTTCGGCCCAAGGGACCCACAGTTGGTACCCACCCTAATCGAGACAGCCAGAAACGGCAAGATGAAGTTCGTGATTGGAAATGGGAAGAACTTGGTGGACTTCACCTTTGTGGAGAACGTGGTCCATGGACACATCCTGGCTGCAGAGCAACTCTCCCGAGACTTGACACTGGGTGGGAAGGCATTTCACATCACCAATGATGAGCCCATCCCTTTCTGGACATTCCTGTCTCGCATCCTGACAGGCCTCAATTATGAGGCCCCAAGTATCACATCCCGTACTGGGTGGCCTACTACCTGGCCCTCCTGCTGTCCCTGCTGGTGATGGTGGTCAGTCCTGTCATCCAACTGCAGCCCACCTTCACACCCATGCGGGTCGCACTGGCTGGCACATTCCACTACTACAGCTGCGAGAGGGCCAAAAAGGCCATGGGCTACCAGCCACTAGTGACCATGGATGATGCTGTGGAGAGGACCGTGCAGAGCTTTCGCCACCTGCGGAGGGTCAAGTGAGGGACACTGGAGGCTGGGCTCTCTCGACACATTCCCCAGCCAGTCACTCCTTCCCCTGTGGAGTGAAGAAATAACATCCTTCGAATGAGTTTGCTCTGAGCCTGTGACTCCTCCTGCTAGGCAGAGAGCGCACCCTACTACTTCCATGACAACAAAGGCAGTAAAAACAGATATTTCTTCCTTCATGGAATTGGATTTGGATTTCTTGAAGCAGGCAGCTTCATATTATACTGATTGGCTC + KK(KKKJ?KIDKKJKJKKHJKKDI>KIH?>JJH>KJC+KKKH?HBKJEKKKIKKKBK@K'KKKF->KKJKKKCKKJKKIKKKKIKHJKIKKKKKFKKKKJJ#3HDKJBG$KKK9G>KJKKKK>KIK7KKKH6KKAKCKJFKKBKHKC3KKFDJKKKK;KKIJKAK1KDKKKEKKKKKKJJKKKKKKKHJJK8K.KKKKKKIJJKJIKKIIKKKKKKKJCKGJJEJFKK%KJKKKF:GKKEKJKBKJK'KKKKAKEKHKK>BK4KKEDKKJKFKK+KKKJHJKIJDJBKGDKKKK9I9KKKGEKK5JHHKKK>KKCKHKKKIKK>KKKIKCKIKKJKKK2KKKKKKHKKJ7KKKJGKKKKKKKJKJJK2KK5KDEKCKKIKHKKKEK?K0KKKJGIEKKKKCKK5KKEDKKKKKKKJKJKKGK8GIAJFKKEDIIKKKFKKKKKKE5KKAK:KKKHKKKKKKKKKKKKKHKK@KKGKKJFKKKDKKKK)J2KKJKEKKIKEJ8IEH:JKJEKIJKJKJGJK@KKI'KKKKKKIKJFA@HKJBKKKKKK>KEKBKKI/HKKKKKKKFKHKD?KKK@KJH;KCKKKF-IBFBKKHD5KKKKKKGKKKIKKKHKKKKKGKKKKKKEKKKKIK2KKCAKKJHKKJ?JKH8KKKBKK7KDKKKAKKJKKKKII7J*IFJJJKKG(KJJJ:KK0KKKD*KJKKAKDKFKKHKJJKHHJKIKKKKKKJKKC8JIKKKKD89(KKK:KHIHIKKKIE)KKJKKIJKKKJ>KFKKEIJKKKK(K3KKG@HJKKDIG7GACJKHHKIJJ6=JKKKKKKKFIJJKKKKKAKGKKIKKIKBKKJHKEKKJ@82JKKHKG4KKHIJIJKIKKJHJEIEI0?K;KHFKKKKKKKJKJKKKJHD:KK3K2KKKKJKEK?K9KJJJJJKIIBKIDKJKKKE5KHJHKJGJJ@KKJKKJKJKJGKJFKKKKKKKKKK+KJKK.KG>999=1=9.:==/=:7=;<:<68:55-57>?=>=5>>;><=9>><2>>3?9>5299:1:154=;:*88?=9?>>?9?=>=762:==99=>8>?:=9<<6<16;:=2;>=7=4>9?=8=8?4;;=:99395==5:;?29>6583::;<7=0;?:998=?;4>=967>.782=?:<>=82866>?9:,>4=?=<;:567;<=;196-:;2714.4-8=7;99:8:6*;>7296>=0:;<6:5=;0<6>=:>:5=;=>?;<7;:4<>=62:79?><39=2?=6>>3<=??;<:?>;2>;:?><>;<;83793>5;2;==;8,57696>==>>/3>?>17<2>><<8<>:>=<:5=87?;>=9:89><;<=>:<3=>;?>;;<82:<5=5=?<98329>999=3=<>>;=>??4<=764/7<077';77>??=>=;:579>>;;57:6;28=<2>8:99?=>=2;=:82=>>9:=895::2<08?<=88;%98>?88;3==:>>9<=1=>92?2=:<=8:==9:?>36:><;+?8=3<==6:5>>6;;3;9=88<=2:7857??7>9;68=>?;>;:988<-?==647=:6>?>>?99359*:<<&::/<999+565::9;>=<3=:=:===(;:=26<.;=9?9;8:2<1? @rCer/212/2399_59_CCS ATGGGGGAAACGCCAAGCGGAGAGACTCGCCGCCGAGGCGGCCTGAAGGCAGCGAGCAGGACAGCAAGCGAACCACCTGGCCGTGTTTGCAGCCGTCCACCCGCCGGCCCCAGCGTGAGCTCCAGCGTGGCGTCCAGCTGGCGTCCAGCGCCGGCTCCGGCAGCTCCTCCCCACTGCACTGCCCGCGCCCCCCACCGCGCCCTCCCGCTCAGCCCGCTGGCAGCACCGTGGAGGCCGTCCTCGGTTCCGCGTTAGACCACATCTTAGCAATGTGAATATTGCTTCCCTGGAGAAGGATCTGAAGAGCAAGACGGCCACGACCTGGGACCAGCAGTGCCAGGTCGCTGGCCGGCTCTGCGCCTGTTACCATACCCGGCTCCCTGCCCGAGCACCATCGCTGCACTCGCCGTCCTCCGCGTCCACCTCGCACTCAGTTCGCTGTCCCAGCCCTCCCGGGCCGGTGGTTCCTCGGCCATGACGCCTCCCAGCAGCCGCCACCCTGCGTTCAGAGCCGGGTGCACTGGGCTCTTCAGCCTCATCCTTCAGCTCCTTAGTTTGAACGGTGTCCCGGGAGCATCTGGGACTTTGTTTCCGGCAGCTTCTCCCCAGCCCACCCTATCCTGAGCGCGGCCCCCATCCTCTCGGGTTCAAGTCCAATGGACTGAGCTGGCCCGGGTCAGACGGCAGCTGGACGAGCCAAGAGGAAGATCCGGCAGTGGAGGAGTCCTGGCAGCAGGTGAAACAGGTCTGCGATGCTGGCAGCGAGAGGCGCAGGAGGCAAGGAACGTGCCCGCGTGGCGATAGTGACCGCAGCTGGCGCTGCAGAAGAAGGAGGAGGTGGAGGCGCAGGTGAAGCAGCTGCAGGAGGAGCTGGAGGCCTGGGCGTAGCCTCCACACTGCCGGGGCTGCGGGCTGCGCGGACATCGGCACATTCCCTGCCTAAGCTGCACTCGCTGCAGAGTCAGCTGCGCCTAGACCTGGAGGCGTGGATGGCGTGATCTTCAGCTCCGCGCCAAGCAGTGCGTGGCTGCGGGAGCGGGCCCACGGTGCCGTCCTGCGGCCTGCCAGCACCGCGTCCTCTGTGAGCCGTGTGCGGCCGCCGCACCCGAGTGCCCCTACTGCAAGGCCAGCCCTGCGGTGGTGACCTCAGCGGGGACAGCACCTCCTGCTGGGCATCCTGGCTCAGTGCTTGTAACCACAGACACATCGTCACTCACCTCTGTGCCACCGATGTGAGGACCGAGGCTGGGAGCCCCGCCCGCGCTCAGCCGTTATCATGAGGCTGGGAGCCCCGCCTGGGCTCGGCCGGACAGCTTTCCTGTCACACGTTGTCACCTATCTAGTCCTACCGACGGTTTCAAGGTATTTTCCTCAAAAACCTTAAAGGCAAACCCACAGAACCCGCCTGCCTGTCCTCGAGGGCCTGGTGCCTCAGGGTCCGCGTGGCGCTGTGATCACAGCAGTTTGTGGTCCTGACACTCTGTGACTGGACCACTGGGGCTGGGTCTTTCAAAGCACTTTGTAAACCGAGGAATTTAGAGTCATAAATTGCTCTAAGCTGCTTTTTATGTTGTTTTTTAAATATGCGATAATATGAAGCTTATATGTGTACTGTGAACTTAAATATTTCATATCAGTTATTGTCAATTCATAGTATGCTGAATATATTAGATTTCATATTCTGAAACTAGTACTTATGAAATGAGCGTTTATCTAGTAGTAAGACCTAGGATTTTACATTTTCCATTAAGTGCATAGTATTTATAAGCAGAGTGATTATGGATTTAGATGTTTTTAACTCGATGAAGGAGCTTGTTTTCCGAGCCTGTGCGCACAAGGCACTAGGGTTGATATTCCAGCCTCGTGACGTGGGAGCAGGAGAGCTCCGTCCTGCATTTCTGGGATCCGTGGCCACTTTCCTATGTGCCTGTGCCTTGCTAAACAATGAAGGAACATCATTGGTTTTGTTTCTCCTTGAATCTCTGAAGACAGTTTGGTACTAACGAAAATGCAGCAGAAGGATCAGACATCAGAGGTTTTAGAATTACCTTTTTAAGAGCTGTCTTCTGGCCGGGCGCGGTGACTCACGCCTGTGATCCAGCACTTCGGGAGCTGAGGCGGGTGGATCACCTAAGGTCAGGAGTTTGAGACCATCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGGCGCCTGTAGTCCCAGCTACTCGGGGCTGAGGTAGGAGAATCGCTTGAACCCGGAGGCAGAGGTTGCAGTGAGCCAGGATCATGCCACTGCACTCCAGCCTGGTGACAGAGTGATACTCTGGC + EBA9<>%7C7;EGBA:<::1EE@;?;<>B6273344=&593@(A>D:71?5BEFB=ECE?:?9BDF49%5512$<:0=@-76>C@>C.ADAED-C0@=AB?;:&D:CB@A5EE@A>?=?DA;>A==<<<=7+7;-)?<36$/8@$52>CE=D@1?4DE.A:>;7A1;2D=FCAC>@EGA9>>+C7B4>;5G=4B<=$020@B3BA??:?66DG=?@6BEABE>)A3BDA@$<59:@;D37<@E'BD<9=;7*:A>6=B?@@=@=A3B-A)>@5A?8DD<08++>?=68FC?:>;23B=CFG:@>>(;86>=<9?9AF69A=$9AA;?==7BC@1A=BB?39@=&09;':8(6/5:58%2.?.@CF3G>C>96B=E:>@=+1DB5?@<@?8105)==<B@B=8=1BA/A;A>*/>B(6?8?8E;?<%D;:;>0<%-4<24A/A;757;,BF3@?-=3763(7-9?@%=AA6$->='C,?A2>C4-85&-0BA%:12E;=82:'DA'>B&>F@?;=>6A4?>BD>2>A='22;)64@(=+<0??881=8>4A++3(1/6E/*E-24)>>;3?58=3:=C2>A@=@61=8(?B=FFEB?:A>7*8>?A@@D@5),*?(D6DE?ACB(DB6>4)%985<@C9733&676:=71A>3/57'/5;BBAC;?=64=7;:1BA3;A?CD:AEB4@AA96=5;8@/4C/>563B=>A28,?D7;A982:<+:@5<<;=*7B>>CG>;AAF?@:C?1%?CEBGA@>47)<-=B><:D@?>90&2/$.90=@D2ACC?;:=)=BG3C?F==='>EB24?4;B.A4@7B?998=9<11B/?BDBA@A7:?<'9194;??C(;?E>F?;<<'.2<:<8)12<=58@9@C?FFA@ADD6:5;>),@0CC/?C2=BD+EF?CBDC>;3$4?CE<72@:C2@+;B3A663:7CFC;A;=:72>4301=AC4@F0?9?3:?BE7:>DD?0>-5:@=4B:ED@-EGAEF@3:6;C-9'D=>=>E=DC0=453C?@B=7;A=FCEBGB=;D9@DCCC3@><:-.@6+1;A-=<9589:87@>&82A<>:91';@:@B%3;29>9@?>A@@6BC5@;@=CD>@;@DD><%1>=?:12E9?F:@80:=;'52;=2?5BGEG:>.CAA+B.C@2>;4$;@@@>C.=0D@@<:?69<=A?=6:;3=6@E3C;:C?>*8<+=97=>;81.%3(8'5':54'@DAECECC?B868,D88>1DC:919A2==:C@<6;?%9=>8;::B>-AEEB<+><:;>@CFDDBA7?4;F@/337A@E9<=?><47-=A=9834+??A?:98:?-A7:58$>0A=?<7??9A<7-@+:744.5BB:<599B@<9;998:63%/86-4+7867974;=07(6870;<*>===4=>?:;:?6>015;7$+2::8=83=39=:6;(;9<1+9<4;8#3;=76*;*52=;763?:96**566&277(;:>;4862:<88$16;-:98'7.72335/3677:&79>=><=;7)9$9<=<4532>5959:0:=;,8;:37+/:0;;63'9,+;:8=:>;;:;:,98;&7>9==;<*7:780:3>;876$6::75&<<9*5=9:*07>4;:6:2<>87+92390849<<32.$747:29.437:'19;4*45%9>30322869989:.;=>>=5:.?>;:?638$8,/>456)68$9964:73838<=,4;<,962;;8:*502<9.48:239=,;9>8;.;>8<+<=7;;1;?99):>0<=<44=6:;>27;2=:0/177(6:6399(2:663 @rCer/215/0_681_CCS CCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAAAAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAATACAACATCCTGGAAGGGTTGGAAAAACTCAAACATCTAGACTTTCTGAAGCAGCCGCTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCACAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCGCAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAACAGTGAAAAAAGACAAGCCAGTAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAGGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCCGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGCAAAGCCTGAAGACAAGAAAGAGGAGAAGGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAGAAGTCAAAAAAGAAAT + S#&/1(0//6465.3-54065+111/++777:5::0653.'+.95/+5+25.24.=646<.=%3358=639<8>C>@871BAA.@>6@9%>./8:6<1#7@@7@83116??:BA:.60=;8=%94;-?BB=@-@2;A?>>;39<777;:<:;321:>7.4.6/8<;-66<97731/9;==:>7>=:62.9B==67-8;>=97?>0?852=:<3@=<<881=>=;59/:=;6:?:<=<<:06*89:99:5;97:><;9<4C<::>1@===?8?4@BB5>>AB?:95A@53)9:.=>1@BBBAA?BBB==5B>=@?B;;<@?A2=?,8A?<2>49.>31<4==?C;?2#>><::30A93AC.>88B,:>;@=8=0?8@B88:*?@@8@A37?C0/9<<>B@>@7C4C3C744??6?=>@?99@=?>A@>A@=;A8<81?.A=-?=<@?BACABC5@7:97:BA;A:C=A7?=?B<>9<>@9CA;>>9CCA5:34=A@8A9C@2B@;05B685>AC3CAA<>C4CC069A@9775:BAA7?BA>7=69B47%8@;43;8?A@@.A=B@>AA2C6ACCC8B.BA=A?+<6?C4A>@:(DD?A@9>78B*@ADA;8.5DC @rCer/216/24_1932_CCS ATGGGAGGAAGGGAGGCGGCGGCGCGAGGAGGAGGGAGCGGCCGCGGAGCCCAATCGCTCGCTCCCCTTCCCGGGTCCGCGCGCGGCGCCGCCTCCGCCATTGCTGCGAGCAGGAGCAGGCGACGCGGAGCTCGGTGCGCGGAGCTCCGAACGCTGAGCTGACCTGCCGGAGCCGGGCGTGGCTGCAGCCTCGGAGCTCCCGGAACGATGGTGAAGTTGGGGAACAATTTCGCGGAGAAGGGCACCAAGCAGCCGCTGCTGGAGGATGGCTTCGACACCATTCCCCTGATGACGCCCCTCGATGTCAATCAGCTGCAGTTCCCGCCCCCGGATAAGGTGGTCGTGAAAACCAAGACCGAGTATGAACCTGACCGCAAGAAAGGGAAAGCACGTCCTCCCCAGATTGCTGAGTTCACCGTCAGCATCACGGAGGGTGTCACCGAGAGGTTTAAGGTCTCTGTGCTGGTCCTCTTCGCCCTGCCTTCCTCACCTGCGTCGTCTTCCTGGTCGTCTACAAGGTGTACAAATATGATCGCGCCTGCCCGATGGCTTCGTCCTCAAGAACACCCAGTGCATCCCAGAAGGCTTGGAGAGCTACTACGCAGAGCAAGACTCCAGTGCCCGGGAGAAATTTTACACAGTCATAAACCACTACACCTGGCCAAGCAGAGCATCACGCGCTCTGTATCGCCCTGGATGTCAGTTCTGTCAGAAGAGAAGCTGTCTGAGCAGGAGACTGAAGCGGCTGAGAAGTCAGCTTAGCGGGATGGGCAAGTTCCTTACAATGTGTCACTTGCAAGTAACAAAGGGACTTGAGGGACATTTCATTAAATATAATTACTGATTCTTTAGAGGTTACTCATTTATGGTGCAATTGCTTCTGTTTGCTAATGCTGCTTTGCAAATAAAACTTGCTGCCGACCACCCACGGGCATAAAATCAAGTGCATTTCAGCATTGCCTAAAGCTCTGACACCACTTTTCATGTTAAGATCTTCATTTAGCTCCTTTACTGGATTTATTGGATGCTGTCAAAAAATAAATTTACACTGGATATGCCAAGGGTTTGGACCTCAGATAAATGCATTTTGTGGAATTGATTTCTTGAAACCACCCTACTGTCTGCAAACCTTCCTCCATAGCCATATCTAGAGTGATCTCTCGCTGTGCTAAGAGCAAGCCTCCTTCGCATTTCTTCCACTGCCATCAGCAGGTAACTGTGCTGATGCTGCCAAGATGCACTGTAGTGAGTGGCATAGAGAATGAGGACAGAGACCCACCTGCCCCCCGTGCTGAGTCCTGAGTCGGGGTGGGACGGCCCTGCAATGTGGCAGGCTCGGTGTGGGTTTACTACTCTCTCCCCTCTGACTCTGGCATCTTGATAAGGAGGGAGGGGCACCACCCACCTGGGTGGCGACAGCTGGGGTTCGCTCCAGTGTGTGTAGACTGGCAGAGCATGTGAGGGAGGGGCTGGGAAGAGATGGGCCTGGGCCGGTGAGGCGCAGAACTCTCTCCCTGCAGGTGGTCTGTCTGCTCTGGGACGAGCTGATGGGAAAGAACGCCCACCGGCCCTCTCGTTCACTTCTGTTATGAACACATTTGCACCAATAGCCCTGTTAGTTTTAAAGAAATGAGCTGGGTGGGAAAAGTGGAAAATGTAATTTCTATTAAGCTAGGGCTACTTTAATTTTTATTCTATGAAACTGATATCCTTGATGTGGGAAACAGGCAGGAAAGGCTGTGGGGTGGGGGGCTGGTGTGGCACCGTGCAAACAAAATGACAAATTTCAACTCACGATCTTTGTAAGAAAATTGTTCCAGTTTGAATCTTGATATTAAAGTTTATGTTTACAAGATTGCCAGTTAGATGAACTAAGTGTGTAAAACAATTAAATAGAAAAAAGACATT + 4*(2--%-36156/)14125263625-46/034(12,0604/644.246456,2/445.1425/56531464)322-0134531010434//42465565061./15//001*02361022+/531050-.23343,040*133.//11(2424664113511214-6,44/04,241-1$3/4263(/32/.4544)*551515/2104545-3*+2%*,-46226+32.14+05-03)05522436/4.)06235414**%(543.5.14610,'/1,25-6641440-15.'132.4554566166354653505354652)30,1/5201646-23411,2%112/2*244122240,2003,.2044645263436,453664300.1152%021221-3364365*4144632.255022345642353463/3414/555152)0/6514..4445.*0-+50*0555.621$,5-223144000213*2,20/3-6413356534,.33-415452,52.2*.*/2452-555+5+44-/3306554-1/1$/.24-316565214/4,440236.653622-460443),105,4,/15265343,64+4.-55+4455156)2/41002/0*/'./3545551-,$)*246/5/66440+41-0.1642511544153440140//-1135/0-4544352/,24.5450.(,+-040332+/1+4610144426526240264100/15102*51-('-23*3413'/01-41124444*454344/5./)1--6636660#.//36645.(0341.6.4405452266441.,20,52014/60235215+250+.5531/3140/,03/1(43-4434.34.43153130231*0/0-%*0144(/,)-.1/.322)55302)-//,7459:447/598.2580963:8,5&+$554/535251+386582656:8;659,/911.163:5889.999:6$3266769;9;74888::2$6:9984389+992848:7;67:53363;,86-::698:99:930357:7555'6335:7:9;7;::6978,993999:5447087885512428878:;6;4:;:5997784+79/-388.8631530/86::0848:972::260/:79:.78498288.174:59.4+838:6677697/:99:818896%17..,53989:6::7::566.2,0,598,*52798;768487:49655/:673628*6794857655/'445968957619794(8779(505556919896778135.487;566,9436766463/30,3,-84:7:94374557577328/7/69-334;74)859985:52986.881:41/7:6::36587;;6+8899.7;827:6:7642948:4;8.9885956261/7656:;:556;886579:3498999478174:468.:9:7767;672655'1169/53;78;:76107879/9789878:9:3-44048700636;52,779:;9;-84864144786::;:57-8676894-885;957:696:744/::8:751/$6542787&8842055:7;;739:66;99)36%21/266437;;15-296;:8580399868+8727/9:8:54848731+351375563$1495827/5;;49;::4855(59;;57/&/7264411:9698735748(0982694/376;98+8865676463*3551:,7463467:.52:4-667:?<5<2)0477817;5;:174?9::<::7<45.860883:0855616+;<4;63(84=5;:.856*417=6::-9=45-55:-84145%799:70/675< @rCer/219/2249_56_CCS ATGGGGGGTAATGTTTTGGCCGCTTCAAGATGGCGGTGCAGGAGTCGGCGGCTCAGTTGTCCATGACCCTGAAGGTCCAGGAGTACCCGACCCTCAAGGTGCCCTACGAGACACTGAACAAACGCTTTCGCGCCGCTCAGAAAAACATTGACCGGGAGACGAGCCACGTCACCATGGTGGTGGCCGAGCTGGAGAAGACACTAAGCGGCTGCCCCGCCGTGGACTCCGTGGTCAGCCTGCTGGACGGCGTGGTGGAGAAGCTCAGCGTCCTCAAGAGGAAGGCGGTGGAGTCCATCCAGGCCGAGGACGAGAGCGCCAAGCTGTGCAAGCGCCGGATCGAGCACCTCAAAGAGCACAGCAGCGACCAGCCCGCGGCGGCCAGCGTGTGGAAGAGGAAGCGCATGGACCGCATGATGGTGGAGCACCTGCTGCGCTGCGGCTACTACAACACGGCCGTCAAGCTGGCACGCCAGAGCGGCATCGAGGACCTAGTGAATATTGAGATGTTCCTGACGGCCAAGAGGTGGAGGAGTCCCTGGAGAGGCGTGAGACGGCCACCTGCCTGGCCTGGTGCCATGACAACAAGTCCCGGCTGCGGAAGATGAAGAGCTGCCTGGAGTTCAGCCTCAGAATCCAGGAGTTCATTGAACTCATCCGGCAGAATAAGAGACTGGACGCCGTGAGACACGCGAGAAAGCACTTCAGCCAAGCAGAAGGGAGCCAGCTGGACGAGGTGCGCCAGGCCATGGGCATGCTGGCCTTCCCGCCCGACACGCACATCTCCCCGTACAAGGACCTCCTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACAACTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCACAGTGCTACAAAGAGGACGGCAGCTCCAAGAGCCCGACTGCCCCGTGTGCAGCCGCTCCCTGAACAAGCTGGCGCAGCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGATCTCCGGCGACGTGATGAACGAGAACAACCCGCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTTTGCCCAAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTATACATCATGTAGGCCCCACGTCGCCAAGCGCACGCCTCGGGGACGGGCTGCAGCGGGCGGGGAGGCCGCGCCTTCCTCCTGCCTCGCGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGACCAAAGATGAGTGAGCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACAGCATTTTGATTGGTAGGATTTTGTAACACGTCAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTTCGAAGGAAACTTTTCTTTAAAGACTGACCTAAACACTGAGGGAAACTTTAGAACGTTTAAAATATAGGAGTCCATGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAACGGGCTGGTCCTTCACCACCTCCCGTTGGCCCTGGCCCGGCCGGGAAGGTGGCAGTGGCACTGGACTGACCTGCAGTGACCCGCGATGCCGCGCCACAAGGGACACTCACGGCTTCATTCGAGAGCTGCTGCCAAAATGCTGGCGCCGCCACCGTCAGGGGCTGGCTTCGAGGACGCCCGCTGCCTCGCGGGCCGTGTCCGCGGACTGTGTTCGTACGTGCGTAGTTTCGATACTACATTGCGGGGCTGTGTTCCTACGTGCGTAGTTTCGATATCACACCCTCCGTGTGCCGCCTTACTTCCTGCTTTGAGAATGTATAACGTGGAAATCCACGGGACCAAGTTTCTGCAGAGGCCTTGCCGGATGGTTCCATAACTGTAGAGTCTAAATACTATCCATTACAGAAATTAATCGTTCAGTTGAGAGAAGTACTGATGACTTTTCAAAACAAATGAACCATCGTAGTTGACAGAGAACCATATTGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGACTAGCTAATAAACTGTAAATGTAAACCATGCGAATAAAATGGTTTTCTATTTCTCATTTCTGTGT 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A?DD=59)0@75BB?D.B4GFGFF?DB7BAAGBFE>>@=>>0=?FGECEB>;CCBEE8DBF;79A@CB;>FB3D2AFBFB>BD@BFA;:CFCDF/BAAFE3@@3?DDDCBC*D@C1?71(??2;ADE;4>?=EFFD:=CCFDD<7::?;=A??=5>&DG?B><8@DA;=?CB?@69?>=8<7:;9D6>@:>?F@BAA?DD?6<;B<;?<07>?A;C=>ABCB=GE@CA@@>96;C2D?G>>>A9E?FGDB;E@D;@G?ABC>DD@D6FBFC@@D@BBEGD@>BEE@??5D@DC@=-B>?B;=BFGECBFEEB9=,@::3C?A;;-B:=C?;A3A>@65<=:??>;C09:=9EB3:C@?=CAG=EGA;=?<69ACEEA?=EAE8CGFCDCB@B9B;;<<;->+?A@=@@A@B91=??ECGAED1@BE7FFG8?D@BECBCCB2<7;:C=FC=>?:8C9E>>E>ECE>@F>@B@EA;;;==C@=?@D0DA@8DDEE>@F@F;@<=9<8=9:@8D@CC8?>@A64B>;D?8=@.FCA:9@FDCB<:A??9=:8=:0:81310+6@9>>8/@@A><7?CAA?>9?FA<8:'>?)61':@7+CB?888>@BA8DGC7>:EFF>>2>D:?BBEB564==?BA<6?@<82'?9>;GCA@@@@=9<7<;=@9#=<4<7<:;*>?8975?<95<@A?3(3@E@DGCE;:A9CC<>EEE(9DDE2FAC0BA9@A9A>==784=A@?>CAC6?A?>5132<798::-08'@44>C@;?B@A=<=ABC9@88>@A<<;97<9;4::<;85;0<8<78;290:'98<=:.4.<:57=>>=9>@AAAB?@@B<599>;88@7;-2<:.868;:;6798,63461:3669:66+*1272$.1+3300294556/+*0/0++,4734302-/2.,7;:4<:717499&<;BA866:9BA;6;.AB<8261(6.1779:4=?A==@46=?;@C@??9=;:?>=<<8907B:B6BB6A=@?4AB;-?<=A96::><)4;9:;;<>3<=B9C=A<606;74*7+802>:75/36:084699;?:@@<9)A???;66>?:BBAB>5<=;;A><*;?<:=@:->@A=88.5:=8@7A;7<@;+99<9731<@?8B==8*67718825*1':9::78=59>2B?28?67=:=':,7AA=BB;286@5=/1ABB>=;40;;:<9C=C==AB7@<@7?=C<@<@A8>?A9@@:9?C5@??AA=;CA7/=@&?>=<:6.<2:;A;;2:>C=>69B<>-<9?=9;8;A>9<8;8>B<>B1?:?=A>6:?5=CB<8A6??97;%<<)>A>B@=:?B8=@:8647;4?1@=>5/;3??@?.6;57/1-$:9B7ACCBBA-C7A;BA79732';::?@8>/>;:<-113,?,@A@@85>A7649=?;A8=9B:679:=<350/'0<8?>:69>B<;6+6;:>=;@-9=<>2=99@:<5>A5@2<934;8:;?>2>@490>B@3?>:8093A::+A8?C;A=B5?9B=>2?B?>>:=9*9*?982:B:@A?BB9?2@C7;475<;8@9A=@?>;.?B94;>45064:@68:35:><9??;9+=<:5-:27-;>;6@=ABA>?7;C<729@>AAA?=;33;=?B<>A=B<=?2473>>6=>5=5.7==?<>8?06>@?2<;:::99:9<8=:8<:36728:88=919:;?>78):8=>77<::=>1<9<<>:.702;=5;08;98466:89, @rCer/221/0_577_CCS GAAGATGTTAGTGTTAACAAATTGATGTTTGTTTTCTGTTGATTTTAACAGAGAAATAAAAGGGTAATAGCTCCTTTTTTCTTTCTTTTTTTTTCATTTCAATTTGCTGCCAGTGTTTTCAATGATGGACAACAGGAGGATATGCTGTAGAGTGTTTTATTGCCTAGTTGACAAAGCTGCTTTTGAATGCTGGTGGTTCTATTCCTTTGACACTACGCACTTTTATAATACGTGTTAATGCTATATGACAAAATGCTCTGATTCCTAGTGCCAAAGGTTCAATTCAGTGTATATAACTGAACACACTCATCCATTTGTGCTCCTTTTTTTTTTTTTTTTTTTTTTAAATGGTGCTTAAAGTAAAGAGCCATCCTTTGCAAGTCATCCATGTTGTTACTTAGGCATTTTATCTTTGCTCAAATTGTTGAAGAATGGTGGCTTGTTTCATGGTTTTTGTATTTGTGTCTAATGCACGTTTTAACATGATAGACCGCAATGCATTGTGTAGCTAGTTTTCTGGAAAAGTCAATCTTTTAGGAATTGTTTTTCAGATCTTCAATAAATTTTTTCTTTAAAT + S*00+,101*$./'#$)%%(--60001(690+05-.-)%412#676$32844.$0.&%/4/&)/-4239/*65;0955122)02.//47512022'2543$4.67.015-6*/14)/21,+075-12;632.4&/1,(33./(6842--)-.*.((13-(461848,097+*+31/.693%32-/+486(4390)7.9623+22:/:63030(/,656:6245:2/4733&31(05'.35,-)-1,*./&,/-,.8211:>16276283617*10-8/;3)<-785-871-.()+6/2228005718753,71.8<70;=<=8%;38::896633889:==:72-(2*/.700747)5437-26.16',,-,/%63./2731-,''+*03)26*,2()&-+,.,*43*#%)&.1-295-38+89-3*)+.'661/1*31.84/370-42-138>:86*,14<:27965167925.-395)265606529.%,773><>62;89133625<97,4;9132.*+101--+9/8)=;6645+4/0'%0,36774*2:5.2676(2)%:57;03.1;'412 @rCer/222/2022_88_CCS ATGGGGGGGGTGACGCGGGCTGGGGCGCGACGGTCTCGGCAGCGGCTGCAGAGGGAGCGCAGCGCAGGGCCACCATGGGGGCCCAGCTGAGCACGTTGGGCCATGTGGTGCTCTCCCCAGTCTGGTTCCTATACAGTCTGCTCATGAAGCTGTTCCGGCGCTCCACACCAGCCATCACCCTCGAGAGTCCGGACATCAAGTACTCGCTGCGGCTCATCGACCGGGAGATCATCAGCCATGACACCCGGCGCTTCCGCTTTGCCCTGCCGTCACCTGAGCATATCCTGGGCCTGCCTGTCGGCCAGCACATCTACCTCTCGGCTCGAATTGACGGAAACCTGGTCATCCGGCCCTATACACCTGTCTCCAGTGATGATGACAAGGGCTTCGTGGACCTGGTCATCAAGGTTTACTTCAAGGACACTCATCCCAAGTTTCCCGCCGGAGGCAAGATGTCTCAGTACCTGGAAAGCATGCAGATTGGAGACACCATTGAGTTCCGGGGCCCCAACGGGCTGCTGGTCTACCAGGGCAAAGGGAAGTTCGCCATCCGGCCTGACAAAAAGTCCAACCCCGTCATCAAGACAGTGAAGTCTGTGGGCATGATCGCGGGAGGGACAGGCATCACTCCGATGCTGCAGGTGATCCGTGCTATCATGAAGGACCCTGACGACCACACCGTGTGCCACCTGCTCTTTGCCAACCAGACCGAGAAGGACATCCTGCTGCGACCTGAGCTAGAGGAACTCAGGAATGAACATTCTGCGCGCTTCAAGCTCTGGTACACGCTGGACAGAGCCCCTGAAGCCTGGGACTACAGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCGCCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTATGCCTGCCTGCCCAACCTGGACCGCGTGGGCCACCCCAAGGAGCGCTGCTTCGCCTTCTGAGGGCTGGGCATGGCCACACGGCCACCCACCTCGCACACCCCATGCCCTGTCCACACTCACCCAGTCACCTCCCCACATTGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCCAGCCGAGCAGGCCCCCTGGGGCCCCTTCAGGAGCAGGGCTGTGTCCCAGGTGGGTCACTGCTGAGCCTTCAGGGTAGGCCCTGCCTGGCACTTACTGGTCCTTACCAGAGACGCCCAGTCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCACACACACACTACAAGGCTGAGGGCTGCCAGCAGCCATCTGCCCACCCTTCCCGGCCGTGGACCACAGTCAGGATGTCAGCAGACACAGACGGGCAGCCCAGAGCTGCGGGAGCCAGGGCCCACCCCAGCCTCACCTGGCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACACTGTGTGAGACATTGACACCAGAAAGCCCTCTTGGGGCACTGCTCCCCGCCCCAGGGCCCTGGTCAGCCGGGAGTTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGAGCTGGCCACGGGGCCCTCCCAGCACCTCAGCATTTCCTTCCAATCCATCCAAACACTGAGGCAGCCTCGGGGAACCCCGAGCTGTGGGGTCGGCAGCCCGCTGCACCATCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAAGTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCCCCTCCTGCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTCGTCTGAGGGACATATCGGTGACCTCGACGTTGCCTTTAGACTACAGTTGCATTAGCCTCTGGCGTATCGGCTTTTTCAGAGTCATTTATGAGCAGAAAAAAAAAAAGTAAAACTTTGCTAATAT + KKKKKKKKK(KKKKKKKKFKKKKK'KKKKKKKKGKKKKDKHKKKKKKKKKKIKK@KKKKKKKKKKKKK@KKKKKKKKKKK6KKIKKKGKGHKJKKKKKKIKIKHKJKKKKKIKHKKKFKKKKKKKKKKEJJJKKKKJKKKJKJKKKK?KKGKKDKKKJKKKKKKKKKKKFKKKKKKKKKIKKKKKKKKKKKKKKKEJKIKJKKKKKKKKKKKKKKKKKKKKJKK2DIKKKKKJKKKJKKIKKKKKJKJJKKKKKIKKKK/JKK7KKKHJKKKKHJKIKKKJKKKKKKKKKKJKKKJIFKKDKKKKKKKIIKKKKKKKJKKKKKKKKKKKKKKKJKKKKJKKKKKKJKKKJKKIKJHKKKKKKKKKKKKKKKCKHKJKKKKKKKKKKKKKKKKKKJKKKKKKGKJKKKKKKJKKBKKKKKKKKJJJKKKKKJKKKKKKKJKKJK=KKKKKKKKJKKIKJJJKFKJHKKIKKKJKHKKKKIJKJ8IJKEKKKKKGKKJFKKKCKKKKK=KKKJKKJKKIKKEKKKKKKJKJCIKKKJKKAGKKKDKDJICJJGKKKKKKHJJIKKKJFKKKIKKJKKKGKJKIFKKKK=KK;KKK:KKKDKJDKHIKKKKKKIKHKKKIKK@IKKIKKJKKKJJKKKKHIJFKKKKK?KFKKKFKKJKIKKJKK>KKKHIKKKK=KKJKKFKK6KKHKKKKKKKKIKJK@JKJKKKJKJKKKKKJKKKKJIJKKKKKKKKKKKKKKHKKKKKJKKKKKIKKKKJKKKKKKKKKKKKKKKKJKK@KKKK:HJKKFJKKFKKKKEEJKKIKKKJKKKK=JKKJJJJJKKJC>KJKKKKKKKKKKKKKK+JKKKKDKKJ3IJJKJKJK @rCer/223/1925_56_CCS ATGGGGACCCTGAAGGTGCTCACCTTCCTCGTGCTCTTCATCTTCCTCACCTCCTTCTTCCTGAACTACTCCCACACCATGGTGACCACCACCTGGTTCCCCAAGCAGATGGTCCTGGAGCTCTCCGAGAACCTGAAGAGGCTGATCAAGCACAGGCCCTGCACCTGCACCCACTGCATCGGGCAGCGCAAGCTCTCGGTCTGGTTCGACGAGAGGTTTCAACCAGACTGTGCAGCCGCTGCTGACTGCCCAAAATGCACTCTTGGAGGACGACACCTACCGATGGTGGCTGAGGCTCCAGCGGGAGAAGAAGCCCAATAACTTGAACGACACCATCAAGGAGCTGTTCAGAGTGGTGCCTGGGAATGTGGACCCCATGCTGGAGAAAGAGGTCGGTGGGCTGCCGGCGCTGTGCCGTTGTGGGCAACTCAGGCAACCTGAGGGAGTCTTCTATGGGCCTGAGATAGACAGGCACGACTTTGTGCTCCGGATGAACAAGGCGCCCACGGTAGGGTTTGAGGCTGATGTTGGGACGAAGACCACCCACCATCTGGTGTACCCTGAGAGCTTCCGGGAGCTGGGAGATAATGTCAGCATGATCCTGGTGCCCTTCAAGACCATCGACTTGGAGTGGGTGGTGAGCGCCACCACCACGGGCACCATTTCCCACACTTATGTCCGGTTCCTGCAAAGATCAGAGTGAAACAGGATAAGATCCTGATCTACCACCCAGCCTTCATCAAGTATGTGTTTGACAACTGGCTGCAAGGGCACGGGCGGTACCCATCTACCGGCATCCTCTCGGTCATCTTCTCAATGCATGTCTGCGATGAGGTGGACCTGTACGGCTTCGGGGCAGACAGCAAAGGGAACTGGCACCACTACTGGGAAAACAACCCGTCCGCGGGGCTTTTCGCAAGACAGGGGTGCACGATGCAGACTTCGAGTCTAACGTGACGGCCACCTTGGCCTCCATCAATAAAATCCGGATCTTCAAGGGGAGATGACGCAGTGAAGGGTGGAGGATGGACGCACTGTCACACCTCTGTGTTTTCCAGCCCCAGCATCTTGCCGGAGCCGTTCCATCCCGGAGCTTGGAGGGGCAGCCTCAGGTGTGTGCCCAGGCACCGCTCACAGCCTCTTGCACCAGCCATTGGCAGCATCTATTCAGCAAGGTCACTAAGCTCTGCCAGAGTGGCAGAGCATGTCTCGGAACCTGTCTTGAGTGGGGACAGCGTCCCCCACCGCTGCCCAGAGCTGGGGAGGCGCTGGGAAAGGTTCAACCTCCACACACTACAATCATTGTAGCTCCCGGAGCGAGCTTGGGGAACGAATGTGGAAGACGCCTATATTCTGAGGGACAGGACAGTTTCCCAGGAAGATGGGCAGAGACTTGAGTGGCGATTCTGTCTAGCACAGAGACATGCCAGGCGCTGTTGGCACCCGGGGCAAGATGCTGCCCTTCTTTGCACGAAGCCCGGCCTCTCGCTTGGCGTGACAACCCTGTCATCTCTTCTCCCAAAACTCATTTATGAGCCACCAGAGGCTCCTACCCCAAAGATTTTCACAGAAACTGGAGGCCAGGTGCCGTGGCTCACACCTATAATCCCAACACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGTCTGAGCAACATAGTGAGACTCCTGTCTCTACAAAAATTAAAGATTTAAAAAAATTAGCCAGGCATGGTGGCACACACTTGTAGCCCCAGCTACTAGGGAGGCTGAGGAGGGAAGATCTCTTGTGCCCAGAAGTTTGAGGCTGCAGTGAACTGTGATTACACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTCTC + 33@;<-5<8/<=>9;86:?::@;4;1=8048=:/*560;<6;?:7-36:83;<6+',643.;66365>74<:4==8=43(59946:*99,8;1$/34+997(7-8B;;>888/?<;?;2?0:@=A287=@?=<0=56?@?BA.;=2:6>B>?=9?18:80:50465+759<=51+6;?78=?-99.424+5C<=.@75>=3:B2=?F>:>CD9:96-06<<10>8B4A:<7;1?:;>=996=A87;'0:=>;643@6:6>??=9>;58?38=966257*4;4>A4>8;.4?>9:318>>=>>4<604A5;>4>C2<>>/A<<>6C@@9::)<7*8;=4=?98(:4?59@?.1@<(7?=<.C7=76<;78=:5>6?68-:3=3::'@0=>6=>7<@;;237(7/:?,6,@:<<<;8*=64;+3;37*:6<27=>>1>;>7,<=76;40?5B987+9;@.05@A46;555<68/335;3-=>-:?5=-89>69>A-:;?<47;<37>>BA@1=@?<3;2=:?87>&=9>8;=.:=:6C84=;5>=:1;1=<939A87;>:3C=:=9<<:6418::=@3:68471;/?@844>;@=A>6:.=;5=?@>9;8>:7?67==0>?;84-3+6-5)>84+:78<96==:48:9@@@4=@>>@78;.;8C<,;>98C>9:5.;8953&7.3;:8=;?=?8;=;3B>=?9@2=7=5>?;4.467-<96:99:9A;B:6=@74346=?*=@;?:><7429'@?AC9=@:5@57B<7A2;;=:8885=;=7:>'AA<8=A;%7=)/>-8)8=A=<>A2%53;>6@>49:3-962.33331/04525*9=C@<*B:39?&A;=79<516<@?>;<:@:640?<<7?B?:4AA9844A1;,<9<1AA:>>;:6?>:>08>@;:2::;(9;-6?;.69;@>9=A>;7;@A2<98A6=<13:3773A=?<=;,228<86)A9377>,;=;@599:@:<57;04872978/&4.3-6:7878376,+0+./*871:>;<66-93/347/2:+32*2/&/:;3>;<899:458677244370;364:/686.242%+2.681-9=99+19;5<9643)39637-//2)477534)1/'/2,44>5=?.>59<-,87<85=95;5<9-8.959799A93714=:6:<698<:9586>1@;7;==253.;;4;.;<7-526;=36.559<=108229=-5:3-1-8/4+889':8;;;9.;2?:;=:29B;:7=7<9<;566=;><2>>=1?64/AA24@=99;?431*/8)2&8C558:>14/40;?9;=79=7;0<8C;49716-:>-A<8;:'8:>><==9;7;8876981829::6=>:4>96::7>261,53>57/:37887:'?::8969;:6>2859$:=467519;9:2766'5::::62=?68><:67496<9<>>35<2+<>>=<120/&-625368573/02#9*16)1605'6489=:1?:=9:87=664,938=63.85;9;95=<:8<68,:385/:2.32-46+4>>>:178;0;:;64;::<8;>:85&:86*7<<,:;>49/6;8473729;=:9090193?73:<7<8932).:118;90,02667/5885:;325:6+576 @rCer/225/2827_53_CCS AAGATGTGACTCGGCGAGGCAGCTGGAGCGTTGGCGCTGCGGGGCCGCAGGGGTCGAATGTTCGTGGCATCAGAGAGAAAGATGAGAGCTCACCAGGTGCTCACCTTCCTCCTGCTCTTTGTGATCACCTCGGTGGCCTCTGAAAACGCCAGCACGTCCCGAGGGTGCGGGCTGGACCTCCTCCCTCAGTACGTGTCCCTGTGCGACCTGGACGCCATCTGGGGCATCGTGGTGGAGGCGGTGCCGGGGCGGCGCCCTGATCACACTGCTCCTGATGCTCATCCTCCTGGTGCGGCTGCCCTTCATCAAGGAGAAGGAGAAGAAGAGCCCCGTGGGCCTCCACTTTCTCTTCCTCCTGGGGACCCTGGGCCTCTTCGGGCTGACATTCGCCTTCATCATCCAGGAGACGAGACCATCTGCTCCGTCCGCCGCTTCCTCTGGGGCGTCCTCTTTGCGCTCTGCTTCTCCTGCCTGCTGAGCCAGGCGTGGCGCGTGCGGAGGCTGGTGCGGGCACGGCACGGGCCCCGCGGGCTGGCAGCTGGTGGGCCTGGCGCTGTGCTTGATGCTGGTACAAGTCATCATCGCTGTGGAGTGGCTGGTGCTCACCGTGCTGCGCGACACGAGGCCGGCCTGCGCCTATGAGCCCATGGACTTTGTGATGGCCTCATCTACGACATGGTACTGCTGGTGGTCACCCTGGGGCTGGCCCTCTTCACTCTGTGCGGCAAGTTCAAGAGGTGAAGCTGAATGGGGCCTTCCTCCTCATCACAGCCTTCCTCTCTGTGCTCATCTGGGTGGCCTGGATGACCATGTACCTCTTCGGCAATGTCAAGCTGCAGCAGGGAGATGCCTGGAACGACCCCACCTTGGCCATCACGTTGGCGGCCAGCGGCTGGGTCTTCGTCATCTTCCACGCCATCCCTGAGATCCACTGCACCCTTCTGCCGCCCTGCAGGAGAACACGCCCAACTACTTCGACACGTCGCAGCCCAGGATGCGGGAGACAGCCTTCGAGGAGGACGTGCAGCTGCCGCGGGCCTATATGGAGAACAAGGCCTTCTCCATGGATGAACACAATGCAGCTCTCCGAACAGCAGGATTTCCCAACGGCAGCTTGGGAAAAAGACCGAGTGGCAGCTTGGGGAAAAGACCAGCGCTCCGTTTAGAAGCAACGTGTATCAGCCAACTGAGATGGCCGTCGTGCTCAACGGTGCACTATCCCAACTGCTCCGCCAAGTCACACAGGAAGACACCTTTGGTGAAAGACTTTAAGTTCCAGAGAATCAGAATCTCTCTTACCGATTTCCCTCCCTGGCTGTGTCTTTCTTGAGGAGAAATCGGTAACAGTAGCCGAACCAGCCGCTCACAGCCAGGAAATTTGGAAATCCTAGCCAAAGGGATTTCGTGTAAATGTGAACACTGACGAACTGAAAAGCTAACACCGACTGCCCGCCCCTCCCCTGCCACACACACAGACACATAATACCAGACCAACCTCAATCCCCGCAAACTAAAGCAAAGCTAATTGCAAATAGTATTAGGCTCACTCGAAAATGTGGCTGGGAAGACTGTTTCATCCTCTGGGGGTAGAACAGAACCAAATTCACAGCTGGTGGGCCAGGCTGGTGTTGGTTGAAGGTGGGGGGCTCCCACTCTGTCACCCCTCCCAGCAAGTGCTGGACCCCAGGTGGCCTCTTGGAGATGACCGTTGCATTGAGGAGGACAAATGGGGACTTTGCCACCGGCTTGCCTGGTGGTTTGCACATTTCAGGGGGTCAAGAGAGTTGAGGTAGTGGGCGGGATTCCAAGGCGAGCCCAACTGAATCGTGGGGTGAGCTTTATAGCCAGTAGAGGTGGAGGACCCTGGCATGTGCCAAAGAAGAGGCCCTCTGGGAGATGAAGTGACCATCACATTTGGAAAGTGATCAACCACTGTTCCTTCTATGGGCTCTTGCTCTAGCATCTATGGCGAGAACACAGGCCCACCCCCTTCCCTTGTAGAGCCATAGAAATATTCTGGCTTGGGCAGCAGTCCTTCTTCCCTTGATCATCTCGCCCTGTTCCTACACTTACGGGTGTTTCTCCAAACCCTTTCCCAATTTTATTCCCTTGTTCATTTCAAGAGCTCCAATGCGGTCACCAGCTGAAAGCACCTCCAGGAGCAGGTTGGAAGGCAGGCACCACGGCAGGCTTTCTGTGATGATGCCACCTAGTAGGCTTCCGGGGTGCCCGCTAGGATGCAGAGATGACCTCCCGCTGCCTTGCAAGCAGTGACACCTCGGGTCCTTTCCGTTGATATGGTGAAAGTTCCCGGGTGGAATGGATCACATGAGGGTTTCTTGTTGCTTTTGGAGGGTATGGGGGATATTTTGTTTTGGTTTTTCTGCAGGTTCCATGAAAACGGCCCTTTTCCAAGCTCATTGTTTCTGTCATGGTTTCCATCTGTCCTGAGCAAGTCATTCCTTTGTTATTTAGCATTTTGAACATCTCGGCCATTCAAAGCCCCATGTTCTCTGCACTGTTTGGCCAGCATAACCTCTAGCATCGATTCAAAGCAAAGAGTTTTAACCTGACGGCATGGAATGTATACATGAGGGTGGGTCCTTCTGCAGATACTCTAATCACTACATTGCTTTTTCTATCAAACTACCCATAAGCCTTTAACCTTTAAAGAAAAATGAAAAAGGTTAGCGTTTGGGGCCGGGGGAGGACTGACCTCTTCATAAGCCAGTACGTCTGAGCTGAGTATGTTTTAATAAACCTTTTGATACTTC + .),0+('00,,.<.%+02&'5>>830:3;:65628;8=;69..*:373.-2/$8;6:4=966<1=>=6;/7=<=5230:5<><;06/>=?=CAA9:585;?0:3..4>=2:>=9791:/98<56@7345689=>=1889706>:467:<;;4:>526604*8<;9,21:?;72146774604;;989:,<===89,2158078,978839678002.40-423.,).).1/3&)'360031#-0542(56//-/*+.1.-,,$08.++15/12346.52'2/<=:70,181=8==9<8094=8>8548=78=<5654755(<9::08167.4=<=4:88<.523=;8567(0:49755+85:;82826)772:8<4297;2?6>;5925:1217.%.1626.3.1.-6./*201)4787387>5707245520479=67:=;-7876<=478?7=>?994679:97==87(6=9>=;9).1//70)4071.941*752+-$-7578.4289.882'5324%:8:==;888858;:33+?<796<65>7&'&:750<868.*13948144:@6;>=9A9<8,/65).6:;;782/<941;2:?793;;754:9(96<,<55289;1:25==3797@)=;A755;605:AAA?;;'/18:8/7?8968+/,'3636@=?::B;9,5.9-7;==.=>107:0>>:7-9==7;6=952&8;.6:/,40)++/.$12//1/340>9;59&?:7566'/+67796*38/5366:396;7942./676+.5(45%8/68230476,21898<932520../10+44.9/7<9;939=>;:52:9677(593<9324422.+1)30008/93035+$*8,=:;154-<6-242:37;92:87631141102-,1)5124-6:698393:;;:6626'81/$1/#)&,+0/+./0803(30.00)%-41/057-8>641591+:99:77*510457554'7/73:5'/971**116(.1532/110-#(/10//0%8246*83+162;48<1:;7:739163)96-;907';=<932<<>;5>;=:48?9466<4736;;.9=<<>>=08<4275::78<<:0:514-/452-82;:<3<;81??=4=:.*6:9>=>?>>;<5.=<<86+01656598;:33287748786::0/127'7204;65100(*$14/.225;2827/26:4'53-77997211:99+;3/711524200&2555387644,0,01)**0(++4355626177176.2024/0'140./.7783193267942585-/:,85/&/432-+23'78(134114/)1.%%$-',)(#23:<99<67=98>;3713896767687+23175:9568754237(/546-0591-*--(1*.-,--301,'167830//,*121;6=27481<8=>9=3879=9>>==6778:0<=;=2=7895;5388;9?:78*0;16:::0=>93534923128'5546;90;3/149>68;:7159&7:4=79<7>9;2;:-=4>=>>>9794386&<1896;=:6<==672<1<<:-7:;2=?>:==:0<9:96+?;=<;+8;9<>89:;9784>>9;5540:580/=;83078=+33;;22;1>?<>8>?::9*16*3:,7:0799=9>::;89:4:1<<>799:9=99>371158:9;0;96&7955064;0398$6?42&.;7839989;=<96/6<2=/214/44/9.)4375114033(223-9?9=686;;809>/9=7<12),,'827=2/36788=97><6=87753=;9>6>7=?9;:3:70:)9795819.3/;4>>>8:9(9.771699683=+6336444.0-.,/+42:54,<;#,/11.#6-:=676492503758665;96664--,,++.*08$13(86'7/%28=?<8-%;+4/:>7&6268=>48880<55445:92=8:8-6999(667496&0629;021.8*9:6563+/4(453:7<==:4:84/65736+)(-/+0(02782,/09472769,3).8.9986%(32/70,(543.75802)4312//63:9990-,/.&(559/455&06-977744%.81528--)9899(3455/--)125.73969:;856:334533-4143626694794768(89:4,18083/675956753.75/231,2/)+,%01('41683-*,4/3.321353-+3.7616524668742/33/-'&))./4)2./556*6133.2459;;36:8953+4,4*--324-%/3./2*528)/-1+,.22,:5797.3../'3,((.3-3+42452&'*+54994586319/1011(450843--0/+536+8415*281+1,12,/-.24))415%/224*4433952723/3'/6:.96:53:7515312895:847:7450049:20967::9-/.21:9083(.4+71:45320,2,4443.5%0*3+4:-96/5678255248439-7493-15066851+(.-)-5.464'471-.&32,*57188)4)5264.;9445989.:57997(41941,79/-+664$()/2.3#9:2498:684-.404.44(2;96357-9:86/823883649:9983.9/11+.1%107&08263627 @rCer/226/2307_58_CCS ATGGGGCAGAAGCGAGTCGGACTGTGCTCGCTGCTCAGCGCCGCACCCGGAGGATGAGGCTCGCGTGGAGCCCTGCTGGCCTGCGCCGTCCTGGGCTGTGTCTGGCTGTCCCGAGAAAAGTGTGAGATGGTGTGCAGTGTCAGAGCATGAGGCCACAAGTGCCAGAGTTCCGCGACCATATGAAAAGCGTCCTTCCATCGATGGTCCCAGTGTTGCATGTGTGAAGAAAGCCTCCACCTCGATTGCATCAGGGCCATTGCGGCAAACGAAGCGGACGCTGTGACACTGGATGCGGTTTGGTGTATGACGCTTACCTGGCTCCAATAACCTGAAGCCTGTGGTGCAGAGTTCTACGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTGAAGAAGGATAGTGACTTCCAGATGAACCAACTTCGAGCAGGAAGTCCTGCCACACGGGCCTGGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAGCACGTAAACCTCTTGAGAAAGCAGTGGCCATTTCTTCTCGGGCAGCTGTGTCCCGTGTGCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACCTTAATCAATACTTCAGCTACTCAGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGATGTGGCCTTTGTGAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGACCAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGTCGGTAGATGAATACAAGGACTGCCACTTGGCCCGGTCCCTTCTCACACCGTCGTGGCCGAAGCGTGGGTGGCAAGGAGGACTTGATCTGGAGCTTCTCAACCAGCCCAGGAACATTTTGGTAAAGACAAATCAAAAGAATTCCAACTATTCAGCTCTCCTCATGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGATTTTTAAAAGTCCCCAAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATATCACTGCCATCCGGAATCTACGGGAAGGCACATGCCAGAAGCCCCAACAGATGAATGCAAGCCTGTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGCGTTAACAGTGCAGGGAAAATAGAGTGTGAATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATCATGAATGGAGAAGCCGATGCTATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCATGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAACACACCCAACCTAATTGTGAGAATACAGCAGAGGAAGGATATTTTGCTGTAGCAGTGGTGAAATCATCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCATACGGCAGTTGGCAGAACTGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAGTAAGATCAACCATTGCAGATTTGATGAATTTTCAGTGAAGGTTGTGCCCTGGGTCTGAGAAGAACTCCAGTCTCTGTAAGCTGTGTATGGGCCAAGCCCAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGGGCTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGAAAAAACCCGATGCATGGGCTAAGAATCTGAAAGAAGAAGACTATGAGTTGCTGTGCCTTGATGGTTCCAGGAAATCTGTGCAGGAGCCTGCAAACTGCCACCTGGCCAGAGCCCGAATCATGCTGTGGTTGCACGGAAAGATAAGGCAGATTGTGTTCAAACGCTGTTACTTGACCAGCAGCACATGTTTGGAAGTAGTGTAACTGACTGCTCGAGCAACTTTGTTTGTTTGAGTCCAAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTCACTAACCTGAGAAATGCTCCACCTCACCACTCCTGGAAGCCTGCACTTTCCATAGAGCTTAAAATCTGAGAGGTGGGGCTGCCACCAAGGTGACGATGGGAGCGCAGATGATCCATGAGTTTGCCCTGGTTTCAGTGGCCCGAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCT + 9:;54*;68<.=>=89<==4><=:859285<:>=?>?4=;;48,168+901?380-<:69>>;$46:-=8663>=>54584>;>:?:<8;+668$7<>:73:=:969=998,;358?=1967=>:>;=11031455<9<979;35>=6338*.(1%2.:<>;8:<=2;%$&75<89,=;;25=>>/9.:9>3?<<904$67--);=764=97>08?768;399?6>>;=:3%3=/61%9;=8?:93<>7:9929+682=:8567=)>;?93<46:;;9:;278<6<;>4>:467$/<*0-9><3;=98>:=8:;79=1777'949?7632;7,=:2:=83/4$7==:88)67254<0;;::=,9985:<=9585065>;4;4=?<==8:>5:34.25;>>?9CA?@7>6A?48;487C?73?<;>7?=>5C=:?AA@;.;891;/<@B4;17&676&:<'949>?/9>C55B;=?A@9+:<%<39178<<&7=4=75840:A3??>8795>+&;=77&<5A;>B=A>@<>-?<31;:07.)4;.8@6>A=@?.:8=><8?==;;&=?B?=<<062>@1?7:.25?@;8;=0=9<;@A<@;7697A687?8<57-?;>;&>AC>?DD:;%E@GA8&4C>??@EGAB@;EG::0AIDGHGFAHFEHEEFDI;DB<@F?GEJ=6BCC)J:IBHB?@B@>C>BBG?EFEIBJH@B5=B-A+E7G;C8,D(FHG1IDHGIGHBIEE/EHFC>>/BF@ICHGDI@@D.EA7B5/C5F=I?DIH=>I,=DHF7ADHH9D>@?@=B%:9C2>EHHE2GHF5@;G>>$79@)DFJD>=EB5G54C:CBEC?:@?D*IA@EECIC7@AEC>@BH?BGHDEFAIB?DGGFI?@>BFI@FF8DGG=BF9CFIIBFB4:ACAJ=GAEHHDD@;%IH@IE<=AEDG??>BC(CFEGCF:=2BA>FF>BF>GCB/E3IBEG=CF@4HCCBIEE?848A*A1='=E?FBEHABCGE>-DDDC>EEG8HH2CJ>FGACAB2;E0D?>9=>E@FDC*C5IH@BID?EA1FJGCIHBHGIAD;./C4>:JFDD@ACHFHCE>?A==EABBHJE:G(GCEGA5EHAFAHFEG*EA@=?E?=#DIFBIGDGG;)*E$FIGJF>DEAFHB8ACCEA>'?IF>DB=7>3IEE%.F>BD*AB(?H?EFDC=G)IGH:C?*>E?BGD=FG8CF8DEIFIAB?>@AB=@:CDG+CBIGFAB,FE?GE?AF-A?AGHG?I@3?CGFGD@CHIDGD@>FH,I>A@D>;:;FC?H?B9HEDB5HD@7D@BBDDFE=CG>CCD5BC05F?E@>>>6;FCG9?EG=?>AAH>BDGGHFIF;;.DDIFDDD8I>CD=@B>>B$@@B@C5:E>CC7C957?ABFCAG@9E1CFBD=DGCA?BE96&B785B@ABF;BDE1CC=B3/8CA@@;B3CCDCEFA6@<:(AA5>D/?DDBB5AA6=;;;9/@@6>6=A>G6E??FC;<;<15A9;:7;@CD>@?B9A-:B;=4:483;=F @rCer/228/25_2401_CCS ATGGGGGAAGTAGTGGTTGTCGCGGGGGAGCCGGAAAGATGGTGGTTACCAGATCCGCACGGGCTAAGGCCAGCATCCAAGCCGCGTCGGCTGAAAGTTCCGGGCAGAAGAGTTCTGCTGCTAATGGGATTCAAGCGCATCCAGAAAGTAGTACTGGATCTGATGCCCGAACTACTGCTGAATCACAGACCACTGGGAAACAAAGTTCAATCCCTAGAACTCCTAAAGCTAGAAAGAGGAAAGAGCAGAACTACAAGCTCACTACCAAAGGGTACTGAACCATCTACGGATGGAGAGACCTCTGAGGCAGAGTCAAATTATTCTTCTGTGTCTGAGCACCATGATACCATTTTTAAGGGTAACTAGGAGAAGGCAGATCTTAATTGCATGCTCCCCAGTGTCCAGTGTTAGGAAAAAAGCCGAAAGTAACTCCAACAAAGGAGTCTTACACTGAAGAAATAGTCTCTGAAGCAGAATCTCATGTTTCAGGTATTTCTAGAATTGTGCTTCCCACAGAAAAAACGAGAGGAACCAGAAGAAGTAAGGCTAAATCTCTGACAGATCCAAGCCAAGAATCTCATACAGAAGCTATATCTGTTGCTGAGACATCAAGCTCAGACATTTCATTCTCTGAAATTGCAACTAGAAAAACCAGGAGTATGCAGAGGAAATTAAAGGCACAAACTGAAAAGAAAGATAGTAAGATTGTACCAGGAAATGAGAAAACAGATCGTGGGCACACCTGTGAATTCAGAGGATTCAGATACCAGACCAACTTCCATTTACAAGCAAGATCTCTTTCTGAGATAAATAAGCCAAATTTCTATAATAATGACTTCGATGATGATTTCTCCCACAGAAGTTCAGAAAATATATTAACAGTGCAAGAACAGGCCAATGTTGAATCTCTTAAAGAAACAAAACAGAATTGTAAGGATTTGAATGAAGATGCCAATGGAATAACAGATGACGGGAAAGAAATTAATGAGAAAAGTTCTCAGCTGAAGAATCTTTCTGAACTTCAGGACACTAGCCTTCAACAGTTACTTTCTCAGCGACATTCAACCCCCCAAAATAAAAATGCTGTATCAGTGCACTCTAATCTGAACTCTGAGGCTGTAATGAAATCATTAACTCAAACATTTGCAACTGTGGAAGTAGGCAGATGGAATGACAAGAAAAAAAAGTCCCATAAAAGCAAGTGACCTGACAGAGTTTGGTGATTGTGGTGGTAGTGATGATGAAGAAGAGTCCACAGTTATAAGTGTCAGTGAAGACATGAACAGTGAAGGGAATGTCGATTTTGAATGTGATACCAGACTATACACGTCTGCGCCCAACACATCTCAGGGTAAAGATAATTCTGTCTTATTAGTTCTCAGCAGTGATGAAAGCCAACAGTCTGAAAACAGTGAGAATGAAGAGGATACTTTATGTTTTGTTGAAAATAGTGGTCAAAGGGAGTCATTAAGTGGAGACACAGAAAGTCTGTCATGTGACAATGCATTGTTTGTAATTGACACAACTCCTGGAATGAGTGCTGATAAAAATTTTTACTTGGAAGAGGAAGACAAAGCAAGTGAGGTTGCCACTGAGGAAGAAAAAGAAGAGGAAGAGGGTGAAAAAAGTGAAGATTCATCAGACCATGACGAAAATGAAGATGAGTGTAGTGATGAAGAAGACTTACTAAATAGCACAAAGGCTAAACTTCTAAAGTTGACAAGCAGCAGCATAGACCCTGGTCTGAGTATCAAGCAGTTGGGTGGTTTGTATATTAATTTCAATGCAGATAAACTACAGTCTAACAAGAGAACCCTAACACAGATCAAGGAGAAAAAGAAAAATGAGCTTCTGCAGAAAGCTGTCATTACACCTGATTTTGAAAAAAACCACTGTGTTCCACCATATAGTGAATCAAAGTATCAACTTCAGAAAAAACGCAGAGAAGAACGACAAAAAACAGCAGGGGATGGCTGGTTTGGTATGAAAGCTCCAGAAATGACAAATGAACTGAAAAATGATCTCAAAGCACTGAAGATGAGAGCCAGCATGGACCCAAAAAGATTTTACAAGAAAAATGATAGAGATGGCTTCCCCAAGTACTTCCAGATTGGAACCATTGTTGACAATCCAGCTGATTTCTACCATTCACGAATTCCCAAGAAGCAAAGGAAAAGAACTATTGTGGAAGAACTGCTGGCTGATTCTGAGTTCAGAAGATACAACCGAAGGAAGTACTTAGAGATCATGGCTGAAAAAGCAGCAAATGCAGCAGGAAAAAAGTTCCGAAAGAAGAAGAAATTTCGCAATTAAGATTTACCAAGCAAACTGCCACATTTTACATCGCCCCTTTATTTACTTATTAAAGGCGTTTTG 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rCer/229/2011_54_CCS GAAGTACATGGGGGCGGCGGCGAGCGGAGCCGGAGGAGCCGCCGCAAAGATGGAGGAGCCGAGAGGCAGGCCCCAGTCCCTGCGGCAGGGTGGCACGCTGACGGGCAAGTTCATGAGCACATCCTCTATCCCTGGCTGCCTGCTGGCGTGGCACTGGAGGGCGACGGGAGCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCAGGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGTGAACGTGTGGCCACCAGCATGCGGACGGTGGGCAAGCTCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCATGCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAGGCAGCCCACCACCCACCCTGAGGAGACAGAAGAGGAGCTGACAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGTGGCCGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGACTGTTATTAGCACCTTTAAGAAAAGAGCTGTTGAGATCACAGGTGCCGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCTGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGGCTTTACTGGCTCAGTCCCCAACATCCCCACCGAGATGCTCCCCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCAACCAGTTCAGCCTCTACACGTCTCCTTCTCTGCCCAACATCTCCTTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCTGTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCGGCGGCAGCGGCGATCCACAGTGATTCGGCCGCCGCGCCGGGGGGTGGGGGGGCTGCGCGGGACTCTTTTTCTTTCAGACTGACCGCGGGGCAGCTGCGGAGCATGTCGACCCGGCCCGAAGGAGGCTTATGCGGGATTTCAAGCGGTTACAAGAGGACCCACCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGGTGGAATGCAGTTATATTTGGACCAGAAGGGACACCTTTTGAAGATGGTACTTTTAAACTAGTAATAGAATTTTCTGAAGAATATCCAAATAAACCACCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAATGTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATACGATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGTCCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGAGTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAATAGACAACTGGTCTGTTAATCTTTTTCATCATTGTTGTGTATAATTTACCTCTCAGTAGAAAGGCTAACAAATTTTAAGTGCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAGTCCTTCAGTTTAGAACCTACAAAGCTTGTGTATCTTGATTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATTTGTAATATATCCTGTTTGTATTTTTTTCCAAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTACTTTTTTCAAATATGAATGCCTTATTTTTGAATTCTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATACATGTAAAGCTGTTAAATACATAACTTCAGT 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'$&,)**)*)'%&$'($()$&&'++/)'*1)/+,1..01%1--2/33,03,6(2581671866470410+,#'$.)24215343-11(-%180874-/51247938805<-01.:/9:950(=5744838?2==4<668/47047&8:58.:3974668;(=<75:8162=08%/77;%112=.7477-20.9<9<78:45;::816099::<8;437,4*:7>965939=6177<4=96<93?:957;56.972=81159<.6:58=367.)#14650464-3.8055714-(1=8=029?::;;(;8--960#20').4;080468/9;6-1':9::64839;999<6275197/;;51&)*8?=4;9);5*38788;:)8:?504676.616420/37174/4<84;)018+*95=05-28:;770,;8==7=:4;>>;2)8>1==.747,36:/738032;8442);8987;9/893:478>/<<69781-212;87;-7;899=<5045*::;>>><<=8)36=;6;3<:92=?491862986159>9:?;7=6<.0$2;:)5.+435479&:-::<;.0219.<)3<=><&(046627;280:<3=99,7%(89<;763*;;;9:/54.4*49:6+0408<<8/310256265:4.>:5151)9>;;75654;:=73228>;=;<9<396<433489*8:15:319(:.=54:856)87031+72=;476:847=77>049=/96;>16+787799;)=55.:;:?65?<8;99-,($633$1:=7?<958:?49;;<<3;7*8<3,.10'&%-081*8?;=;:>;:/37749:8:9=4;-5<<=467*<2>8/0=<<;*<932?-<8.@/?3:4@?8=BC>4:?=@9?649?7/)>67?A>6;<0;??<4@;2;=/<4;79621/*&7;658.>8=2):65?@@6=92:B:=@?:<'>262/26>9>983473<635@>4>191/<=<.48412/'4763+/0#,36989:;024697653$6:;7:=:<65.99<<<<>@2==3::=<797:963<=887@>(8;=A3BC7A;?A;9;,4=>>><2=:?9BC=B@C6B4=A@0;:@?=BB63B625/)-'686:;<:;5=9=4:6BACA:<78/,,)<3<864285.%450862@;:4;17?7367*9=4:8886<C8=9;<73@=<>>+38+573@93-/<:5,<@@(28:@/81-1<<@854%217(=399;@55=;=/?773532%77?;:==67977*0206398'88;4#/674615275>=;51;633>:49.02<793<:8/98-:9:79>2186<:<6&83:;>;7;4;:3>354836<7<72179=5:2=:9/)/53><6?4=<583772;==>:.>9=>:9?658<*?;/9=?:6909>:>>;<>=:<63><:18=<5/76382<<:58<8?=<=5<=6<=.89:+77/=9?:749=12-995682.,>:53:/9>=7;(=789=;==1235:9812:-;<5325?637&:=897778<>3782+?6;=825?<9?8?34,568<83>=?>:??43,=958056=84:=8;9;83)2888;;'39=.=>=>6>?7=8897078:8:#:.>=61;<6*025=87,7+=>860;;<1(*/.=;8*9:><85<3=9;8;=8<:1989<114>>:974:<1)27;0,0.98??9>:8;9;:9:)=:?;>;;52+-+99;/>73<9<97/<=9)78>861+68(989268848;9':579';6<7+:38;;;:%96,*82'0*14381:43//#1>=0=;<=3>=66<241&<;91=?9<=2;9=> @rCer/230/1733_55_CCS ATGGGGCCCTCCCCAGAGCGCCGAGCTCCAAGCTCCACCCGCGCTTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAGCCATGGCGTCCTCCGCGGCCGGCTGCGTGGTGATCGTCGGCAGTGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACCTATGACATTGAGCAACAGCAGATAAGGAATGCCCTGGAGAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTGCTCTGAAAGGCTCCCTGAGTGCCGAAGAGCAACTGTCCCTCATCAGTGGCTGCCCCAATATCCAAGAAGCAGTAGAGGGCGCCATGCACATTCAGGAGTGTGTTCCAGAAGACCTAGAACTGAAGAAGAAGATTTTGCTCAGTTAGATTCCATCGTGGATGATCGAGTGATCTTAAGCAGTTCCACTTCTTGTCTCATGCCTTCCAAGCTGTTTGCTGGCTTGGTCCATGTAAGCAATGCATCGTGGCTCATCCTGTGAATCCGCCGTACTACATCCCGCTGGTTGAGCTGGTCCCCCACCCGGAGACGGCCCCTACGACGGTGGACAGAACCCACGCCCTGATGAAGAAGATTGGACAGTGCCCCATGCGAGTCCAGAAGGAGGTGGCCGGCTTTGTTCTGAACCGCCTGCAGTATGCAATCATCAGCGAGGCCTGGCGGCTGGTGGAGGAAGGAATCGTGTCTCCTAGCGACCTGGACCTTGTCATGTCAGAAGGATTGGGCATGCGGTATGCGTTCATTGGACCCCTGGAAACCATGCATCAATGCAGAAGAGGAAGAAACAGCAGAGCGGCAAGGTGACCATGAGTCGGGTGCAGCCTGGCCTGGACCACTCTCCTCATCGAGGCCTGGATCTTTCCATCCACCCTCACAGCGGCTTGACCTCAGCCTCCAGGAGCGCTGTGCTCCTATTGCCTGTCCTCAGACACGGGCCCTGGGTTGCCATATTTACCCCCTCATCCCAGGGGTCACACTGCTCAGGCCACCTAGACCTGCTCCTAGGACAACTGGCCCTCATCCCTGCCCCAGGACAGACAGGAGCTCAGCAGAAAGGCCGCCAGGCTCTTCAGAACTTCTCTCTGCACTGGGCTCAAGTGGCCGCACCGGGCAAGAGCAGGAACCGTCTCTGTCTTCGTGTTCATGTTGCAACATTTCCTGCTTTCCATTAGTTGCATCTAAGTGGAGCATTTAACGAATTAAAAGAATTTCCAGCACCAACTCCTGGCTTAACCCGGCTTACCTCTTGTTTAACATACTGATTTGGATTTAGGGTGGTTTTTAAGAAGGCTTGTTCTCAGTGACAGTTCCCTCTGGACCATGTCACCCAGTTCTTGACCAGCTCTGAAGGACTCTGGAGGCCTAAGCAACTTACACACACACATGCACAAATCATGAGTGCTTCAGTATTTCAACCTGGGAAGTTTTGGTGTATGACATTGTGATGTTATGTTTTGTGGCACGATTTTTTAATAGAGGAGAAAACAAATAGTTTCTGGCTCCCTGTAACAGCACACGCATTATAACAGCCACTTTCTGAACATTCTGTCATTTTCCATCCATCCTTATTGTACCCATTTTACTCATACGGAAATCAAGTCATACAGCCAATAAACAGCAAAAACACGACTGAAGTC + 1,06:+??99::<*:7689<9:>>:>481=77:9:<;??7=<97<8:+;>713:<89>4=9?;>=;9::29<<9.?6>?86=:8595,789<68/876=1=0.+/:6=8:2/78>7::53=53273$176379:?088:;;6;78;*>59;908999/;;42=<=8>?=9:-:*:7(9:<84$3,63=>;178,*556,>=7<15<;1-60:,-53<235=<:=4485:9=7=.78:898:52774493:,:;69<-8174;79+75:<6.>:,369+6/.7<5736<309714.97:9=>5<;99:62.=997:564.9-;:6:/?55:2446.*497;;7>>=4=0>=;;:51:14062677784;27:62<9444<8;2988;6;?7>>:9788:)==<;75>9>=>:>69682=8:6;84159=:8;<7;589843.>::8>2817:;=6;;/<54;7=:87;<7;73+885=8;<2?9=930/,+4$679-354'478;<11=98:<=?9==>:<:1+-94:(7:86211228,508206384(06.27-770:247786:15)1.,0-53-6-414./6..26688+1*1,28778,656-6/'..4;7965&2593495:841-4102)49617/$$.25*0814:19453549/9;452'2:;:48,19.91:6./.9908475;9.08:835.9:3,599,9-'986:508855589.;:4/8577;8106671,)6640304313%(1+85-9+1+0/.7691-9::4:469:46-69:379:958358;/98/207719-(-1%-6545&496-44.06/3*6739:9741375371558757675:;-$'.470;3'7:477:131::879:378-947437936056233-22::7:845317/3:853408399,./.7643356(+8'290-8--2+,203:2/1527)449:86&1779,6643+239//13./7,/:09559:2855:957.5/688475:19703345:709:998(08+6645:3881:76312275439062;9993:;85+7/0//7715428463365816/47'2::;9639563::6;899*3;9/0981:86%3/75729:7648./07433548723873*.,6148213/:218358-57:68814:7:608;55/4451/7429847%8:5,02+46)4/.10/4.-$-&4/985:955-::2;79:5:;949:/9765:547583'40--)96683-486+/7,8344&3.95,0-99020(4037921857951::6327:368-,1465275*263&,5.6:5::5:5:84/.9//95:99*39+24.42684-35-56,--*,1798/875356'77133-7:68-96595/54.27(:5*1:-8-08:9+93,/,32.9:96&765.378.458:750958213,+310213%502536..2236-$-/8*.3:7:1,9;69';;26:63145:3-438-326+--85949503573''465.:92'5:::6+5+2%45026824258132&'365645334(,2-%14/;<:=60:=936;.=.6;49>7;<:==508:52898*:1:82<8<:*799 @rCer/232/1581_57_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAAGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTT + KKKK3KDKHKKKJJKKK*KKKKGKKKJKHK@KJKKKJKKKKKK2KKKKKKKKKKKKKK>KIKKKKKKJKIKGKKKAKKJKKKJIKKKKKKG3KK%KKJKDK8KKKIJKKKKKKKKKJIKKKKKFKKGKKDKJKKKKKCKKKKK?K+KJJJKKK+KIKKKKKA>KKKDKKKKKKIKKGHKKKKIKKKFKKK8KKKKKKKK;KK>KHKKKKK=KKKKKJIKKHKGKKGKKKKKKKKK+KKKKKIKJKAKKKKKKKKIKKJKK5KKK7KKKKKKK@JKIKKKK.FKKKKKHKKKJKKKKKKKAFKKKKIKKKK0K@KFKK1JKKKAJKKKKJKKKKKKKDKDKK2KJKKKHKJKKGKKJKJKKKKKKIKJKDKKKHKHKKKJKDKKFKKK9KKEKKKKHKKJJKKJKKKK4KGKKKGKKKKKKKKKHKJKKKJJKKKJKKKKI:KEKJJKKKKKKKHKKKHKKKKAKIJKIKKKGKKKIKJJKKJ4JKEKKIKKKKJKKJKKKK3JKKKKKKKKK:KFKKJKKFKCIJKKGKKKKKF:IFF=IB@C(JKFJJKIKGIKKEIKFKIIKEKKJJKIJKKJKDKKKK?KKK7KJKIKKK=KKKKKEKIJKKKJKK7KKKK;KIIKHKKFKKFKJHCKKKIKDKHKKKKGKKJKKHKKJJKKKJKJK;KJKK>KKKDKHKHJKIKF@KI;K;JFJJKKKKHKKKK@IKEEJK@KKKK>@KKCKKKGKKKJKEKEJKFKKKKKKKKKKKJKKKKKKFJKKIDKKKKKJJKGKKKIJKKKKKKKKKKKKKAKKIKKBJK8EKKKKKKKJJKKKKGKEHKHIKKK5FJ7KJIKKKKIJK?KKKHHKKKGKKKKKKKHKKKHKKKKKKGKKK+JKKKKKKKKDKK9JKKJKFKK9KK5HGIK2KIJKKKKJKKKKKKKKKK>KKKKKKKKKKKKKKKKKKKK8KKKK+KKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKJKKKKKKKKKKKKIKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKIKKKKKKKKIKKKKKKKKKJK@KKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKHKKKK5KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKJKKKKKEKKKKIKKKKKK4KKK @rCer/235/25_1927_CCS ATGGGGGCGGCCTGCGCCACCATCTTGCTTTCCTTAATCTGGTAGGACCGTGTGTCAGAACAATCTTGAATCATGAAGCTACTAACCAGAGCCGGGTCCTTCTCGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAGCCTCAGGACCTTGAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATGCTCCTCTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTCCAACAATTTAGGAACCACCCATTTGCTGAGACTTGCATCCAGTCTGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCATGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAACCATGGCTTACACTGTGGAATGCCAGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTACTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGTTTGGTTTATCTGGTGTGAAGGCCAAATACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTCTTGTAGCAGAGAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCGTTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCGACTCAGCAGCCATTTGATGTTTCCGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTCGGGATTTATACTATTTCCCAGGCCACAGCTGCTGGAGATGTAATCAAGGCTGCATATAATCAAGTCAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCTGGATACCTAATGTCAGTGGAGTCTTCTGAACGTTTCCTGGAAGAAGTCGGGTCGCAGGCTCTAGTTGCTGGTTCTTACGTGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCTAACGCTGATATCATAAATGCTGCAAAGAAGTTTGTTTCTGGCCAGAAGTCGATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGCTGTAATACTGACGCACACATTACGGGAGAGAGCTGAACATTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAATCTCTAATATAACATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCTCAGCTGACCTAAAGTCAATAAAACATTCTGCTTAGGTGTTTTTCTTACGTTTTTCTCAATGAGTTAATCAACAAGTATTTATTATGTGCTGATATTTTTGTTTTGGATGCTTTAAAGGAGACAGGAATATAATTATTGAGCATAGAAGCATTAGAAACTATTAAAATTAAGGCTAAGTGGCTATCAGTATAAATAGTGCCAGGTTACTATTGGTGGCTTTTCAGATGAAAGCAAGTTCAAAATTTGTCATTTTGGGTATCAATAGCTAAATGGTCTGGTTTTTACCCCTGTTTTGCCTTTTTTGCAATAAAATTATTTCCGAAAAAC + DKCKKKKKKKKKEKKKJKEHKJAIIKIK8KKKKKK=KJIKIKKBKKFIK;JCKJHKKJ@KJKKHJJKKKKJKKIKKKKKGGKJ=KKKJJKHKKIKKJIKAKJHKJKKJKJKK7KIJCKHJIKIKJIJJJDJJGJKCIKKJJFIICBKJJKKKKKGKKJJFKKKKJKKKK>KKIGKBKKJKIKJ+IKJ@KJ8KJKJKKKKJKJKKDKJKKFKKKKGKHKKFHJJKKIGIIKJGKIKBKDKKK4KGJCG:KKKKIHIJKKIJHJKHKKKJKHJFGKEKKKKJIKKIKFKEH>BKII6FHIKKKJJJKJHKIIKKKJJKJFKJKKJK0KKJIKFFJFKIEKJFKJI>KKAIHHIKKIIJJ>JJKIHKDKKK=KHKF>KGDKJEFBKJFKIAJGK;F?KIJK3HI?KKHKDKFKDDEF2GGKKAFKHKIHHKEHG4BF@2JEKK?K?5JI@KHD/HCHKKE3JHJJH=HHGKFKHJC@KFD=ECJGHDKAI/IEJJAKKGK;KICBID?FJIJJJJ7KIKFDKHHIKKJAJK8KKEJJJ4J2IEJI%JJIBI7IJJHJKEJKKJ7KJ;JKEIIKFJ>I,DCFJJG@IHKCK@JFDHCKJJIKHCJHJFJK@AHB@J>CHBH?KBHHJFKHHKGKDKHHFJF5HKGHDJK?IHEFJKJKKGKJGIKGHJJJKJKKGKK;JIKHDHJHAKKCKII-FFFHHH@JKEKEF@JIKJF=KG;=HJJIEBKKDJIEJGJJC:JJE;HGKH@EKEG=67DEEIHI>KEKJFGJFIKGJIJKK=IJ@KFKGCKK;JFFHFJJHHKK>HIIIJJ7HKFCEDG?KK.I=FDI=EIKI@FDKKJDKJEKKKKKJKJCJKJ>JHKDFDEFGGKEGJIKJGKJ8KAJ6KJKJHJDHIJH:=G=@KKKK)IIJBII8JKFGKJKHK9KKJK@KKDI:HI=IJJJFH:IK6KKKJKKK;JKAKJJKKHKK=KKJGKHKEJHBIDKKKKKJJGGCKKIKJGKJFIHKJJCIKJKKHKHKJHKBKJJKKKJKJGKKKIKKIIGJHKJDKJKKHKJKKJK9KIKKE<8KKKKKGHKCKJKKKJKIKKKI@KEKKKGKJHAKGKKIHDGKBDHI@KKGKKKJK2KKKJIJHKKJ=KKJKIIIKDEKKKIJIKJEKJGKKHKKHDKFKKDKKIKKKJFCJKKIE.IKKKHKKIIHJKJIIGCKDKKIKKIKECHEGIEKKK@JAKKKI?IJIJ@KKJFIJIGEDKH8JIKFHKIGIK@KKKKKKKJ-KKIJIJJ:KKKJJJHHJHKK8EIKFKKJJJ?KKHJKIKKEBKIKCH4KKKFHKEKKHAAKKIKEKHKKDKBEKGKJGKJJKKJKJKJ:IHKHJ;KC=KKKJFFJHJJFHJHKKHKGKKKKKKKGJIKIKJKJH>KAKJJK@KCG=KKEFJ;G5FKKFKCKBJKK?KKKGKGG/BKIJ?.BBGKIGIJKKKJIJ1KDCHIGBIEDFG8GGCF5BCHGCHJ;JG6FIBJGGGDIH3@C@;GBCCA;89=<+;,:*F8BJAB55DJ=?CI9@C9>7EFCG@BA8;9GIHG>430HIJFIIJHHADG?EEK18J;IG@=0AB>E@A:J@F-A>JHGKIKFG08<=C@CHKHCGHAEEE.IGI>19-@642+GD@FD8>?H9;@?I6GJGIJC8DCJCDHKE?B?2?.I>8H4F;3=;JFCG:9,2AHB=9AF4-CIEKACHDFCEAH@DEHFJCEBBE@HII@@:KJBJKDJ?A2/1@9>@JK9JI;KDKKKEKKAE8KII:H9:7CEE:EB7>JF=JIKKHJ>9IJ.HEEC?EHGJJ??JEHBCJI?G6DF?AEJI@FE1/3D977;;0@E<@0;@D>JE>GEHCI@CF?>FGGKHKIEJCJ@BBE?FKKG2J;A?=-?G48D5DFJ;GCKBKEH7IJKJJIKCG;G>>9EDFEH=E=IFKKKJFH=KFKCH?BGEIGIA?AHB=:HHGFKAHAJ=AFEEAIHHJ?@HJFAGEBB:I;JJJJCJFKHKBKGDCIKKK:EAGJDGGIEB6;;5:(654:>IB>JKAFIGJJGKD>5?GAB<8DI9H:C<6ECCJGKH;EJI7BA@:>8:G=6>9EEI3GFGDBB8@7=.FD:C1JJBH5BED@4GEJGJ&HD=FGJCDD??=%@EC?BKB?@>B>:F1?5A>E4DA=BDG9GKAHIGKHCD2C<=><=F=J3AI.FBB3J@A35CE-E;6FIKI;27)4+64@H:CIAEJ>CE>*<@HIBJHJJKGAI@EBI3JJJKKJIDKJJI@>?3-9AH7ABCKFHAEGIKGJFJDKEK;IFJJ>GEAIC@@@AB55@AD7I?>4HKEAI>JHEF@IAAEFCB3GD?C7>C7HAC@7>>E0CAEBJ9=DA85:C?:CECJJAH@GFC7DG9IJCFF@BI:>HGDKDJBGF;IHHB'=DK?K>C?7@8;>EB7A:BD8F8DAAF>A6=>?HGD0G@BD=<8AAB-BB?=?<*BB.7@FGCIFIIGEKIDEH=KHIBIG @rCer/237/1627_57_CCS ATGGGAGGCCACCGCGGCTCCGTTGTTCCGCTGGGGCCTCCGGACGCGCTCCCCGCGCAGGTCTCTGGAACACTCGGGCCGAACGTAAGCCCGCTTGCACTCACACTGCAGTTCACACCCGCAGGCGCGCTCGCACCCACATTGCCGCTCACGCGCGCTCACACTCCCCACGCGCGCTCCACTCCCGCTCCAGCCCGAGCCCGCGAAGGCGCAGGCACCGCCGCCGAGAGCGCCAAGGGCCCCACGGCCTTCCATGGCGGACCTAAGCTTCATCGAAGATACGGTCGCCTTCCCGAGAAGGAAGAGGATGAGGAGGAAGAGGAGGAGGGTGTGGAGTGGGCTACGAGGAAGGTGTTGAGTGGGTCTGGTGTTTCCTGATGCTAATGGGAAATACCAGTCTCCTATTAACCTAAACTCAAGAGAGGCTAGGTATGACCCTCACTGCTGGATGTCCGCCTCTCCCCAAATTATGTGGTCTGCCGAGACTGTGAAGTCACCAATGATGACATACCATTCAGGTTATCCTGAAGTCAAAATCAGTTCTTTCGGAGGACCATTGCCTCAAGGGCATGAATTTGAACTGTATGAAGTGAGATTTCACTGGGGAAGAGAAAACCAGCGTGGTTCTGAGCACACGGTTAATTTCAAAGCTTTTCCCATGGAGCTCCATCTGATCCACTGGAACTCCACTCTGTTTGGCAGCATTGATGAGGCTGTGGGAAGCCGCACGGGATCGCCATCATTGCTCTGTTTGTTCAGATAGGAAAGGAACATGTTGGCTTGAAGGCTGTGACTGAAATCCTCCAGGATATTCAGTATAAGGGGAAGTCCAAACAATACCTTGCTTTAATCCTAACACTTTATTGCCAGACCCTCTGCTGCGGGATTACTGGGTATATGAAGGCTCTCTCACCATCCCACCTTGCAGTGAAGGTGTCACCTGGATATTATTCCGATACCTTTAACTATATCCAGCTACAGATAGAAGAATTTCGAAGCTGAGGACGCATGTTAAGGGGCAGAACTTGTGGAAGGCTGTGATGGATTTTGGGAGACAACTTTCGGCCCACTCAGCCTCTTAGTGACAGAGTCATTAGAGCTGCATTTCAGTAGCCAAAGAGGACAGGAACCCTATCTTCATGAGGGAGGAAGACAATGGTCCTATAGAGCCCTTGGATGAGAAAAGGAAACTTTTGAGCTGCACCTTCAGTTTATCCTCAAAGCCTGCGTTGTCTTCATCTAATCCAGCTTTGATGGATGTCTGTGATGGTTGCCTGTACACTTGCTGAAATGAAATATTAGAAATGGCTGTATATTCCAAAGAAACCTATATTATATATCCACGTTACTGCTGCTAGGATTCATATTTGCACGTACTGTTTATTGCTTATGTGTAGAGGGAATGAAACTAGTTTCCAGAGTTGTTATTAATCTGAATATATATCATGTGTTAATATTGAGAAAGGAAAAATACATTCCCAGTGTTAGTAGTTCTTCATTTCCTGTCTCCAACAGAAAATTAACTCATTTTAAAACTAGTGTAATTCTTGATAATAAATTAAGAGTTTTG + JJKK$FHDKKKJ%I:K,GKK>KK?KKAA?KJKKKK0K,GKJK5KKKKKKKKKK)JJKJKK>KKKKIKJICKKKCKKKKKKJIK>JJJKDI,JJKFKKJKKKEKKKKKK*FKJKKKKKK/KJJGK)KJK&JJK-KKJHIB6KKKKK;KKKJKKIKKKKKKKKGKKKKHKK*&GDJG9KHKK9KJKKKEJHIK=BFF'*I-IIJH>D?FD<:IKKJKHKHKKKFJHKK?J>AKHF'GKJBIJ/IICJIG4KGDKKBJKKHKKJKKKKECKJB?CIEKBHIJJKD=<*=IIHF>JII=)GKH6KIFKKGDKKAKKDKK8F9?FJ@?+FCB9JKKKHJKKKFCKJKJKHH=AJKJHDH;JKKKHIJ@KI>FJK6JIKG5JHII?KJKFKDJGIJKK@GDK?JIHDIKAJJEGDEJID>DECGJ&KHKKIBJDHJJH*KKKKHFKKKIJAKKJKKKK+K:KGJKI.EFJEIADGH>FHKIIIIEGGJHJKKI=HKB@=BHKIIJKHIHAAJJDKK?KKJKHKCIJJKHGIJ7KJFEKK6AHKIKJGCKIKHKKAKIKKKDG4/KJF<;HJHHGGJEKH=GBKCKF@KKKHK:JFIDDH7JEIHFIKJ9IF>GDKJCFFKIKJKKFJK@KK?GEKKKKKKCJJIHE8DKKKCFHIBIJKEHJ@HDJHK>KKIIH=JGIKKK;KK6KFJJKK>FKKKGJKFKGKA;KCFBKKIFKIGJKKK&GHDKHKHKFKKJIK=JKKHK@KHKKKJHJKBI'IIKHEGKJ6K9IKKKGJKKGIKKCKKKK@FKKK>JB?KJKKKJJKIJGKJKK;KJKKJKKGKK>JKK+KKKKFKKKKKKFKKJK@KKKKKEGIKKHIJEKKKKKJJJHKKKJKKKFKI1DJHKK@KKKKGJKHIKKKKKHJKKKKBDKKIKHJKKKDKKKKKKKKIKGKK>KKHGIDIKHKDKKIIJ7KK%KHKCK@JJ@JGKKKKKKJKJKKFKKKKKKFKKKKGJKK>KHKK?KCJKKJKKKIKKK?KIJKKKBHCJJBAJCKKIK>KKKFJKK?EKKBKGKKJKKKKKFKKKKKKKKKJJKKKK4KKIIKKKKKKJKKKFKIKKGHKKJEJKJ?KK8JKIGKIDKK@CFKJKKKKAKKHKKIIG>KKIKF@KGKJEJK8?KG @rCer/241/1852_59_CCS GGATTTGTTTCGGGGGATAAAGGAGGGACCAGCCGCTCATTCGAGAGGACGCAGGAAAAGAAGCGCTTCAAGGACCGGGACTAGTGGCCAGCTAGGTGAAGGCAGACAGCGAGTGGCGACGATGTGATTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACGATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGAAGATGATGAGTCTGTCCCAGAGAACGTGTTGAATTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCCACAAATCAAAAAGTCCGACTCCTCATGACGAGCCATCCTGAAGTGTGACGCAGAGCGGATAAAGCTGGAAGCAGAGCGATTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTGCCCATCAGTAACGATGAAGATGCGGCAACAAAGAGTAGAGAGATTGGGGTGATTGTACTGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGCTGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCTTCGCACTTGGAAGTCGGGCTACACTCCCATTTATACCCCCTTTTTCATGAGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGAGCCCATCGCTGCCTGCACCGGGATGATGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCACGGCCGTGACACCCGTTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCACATGACAACAAGTCGTGGGAGATGTTTGAAGAGATGATTACCACCGCGGAGGAATTCTACCATCCCTGGCATTCCTTACCACATCGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCGTACATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGACCAGGAGCCATCAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCGGCAGCAAGAGACGTCACCCTAGAAAGCAGCTGCAGAACATGGAGGTCACCGATGCCTGAACATTCCTGCGTCCCTGTTTGCTTTCATTTCTGTCCGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCGCCCTGCCCCCATCTGACTGTGGAGCTGAGAGGGGAGCAGTGCCATGTACCACACAGATGTTCCTGTCTCCTTGCATGGCATAGGAACCCATCACTGATGACTGATGAAACCATGTAATAAAGCATCTCTGG + '%%%'$'''%'(%%#$()))()%#$'#&#$$()($$$$$(()%"%#&%((((()($#"#$'#%()()&()(##&&#"%"##&&#"#"##$%$#!#!"%)')+-((',(+'*,*+,%(/1510/-#%(/*04014+.015/13))10//'41416021)5,1.-24102651+.-//1654.22/01%25/4,*,*)$$-/+2.21061+.012*1*/-&/+'-441(.,+&+$+54-0%00255..%-265626456434.523,.1/.0-21++1//2461/).*)%*.221/*0()0%40221'$'*%,*)#121.$-0*11655/,)(.00413*3544/*410.21-2.(2)1.//-*/+52(/$44,+%..-653435/*.+01(4)5/3-1+..-11*.*14//34')*5/3+421510254(.3/466%,.#21/+'+'*41)()&(3$)##)15320%())./221612+0+/0-/4/+/00230/'01-,41+$'.0))(,)-+//*//4)/4-3/02-44,)&&&%%&.,-(2&$*7+.-03,-+.%605:7(6485(97/2)41(0:66:;990,2+12..28954543393+44,22:+53'3-1$53+)*'*332,#(-.0/.254)453(**28887/8861,2724511,1,.92404/3::3032036.743.47..86825988-02//--47174-,.240722704-57-5+976.7-785.(1'817817+&8*7,+$',#13343/.(3885%,//1*5:1/4,14+2-$013:06606448(*+81.0.31%+)2#+0-12670-3-3329652876451/,-,$364)465938-01*3,366981/$3&34+30-0+'6*+*-+.0*/650..-,-+546-15/(:1.1.12/0'52--6.253.0-6&457808/5*791:639835/791334466682121-0-,6*20+210651514440050-35--*.(+/).'*+*45/4461,-)0.4'1015("/-+%00$+$32242&300154611/242432015303/..51143).401-,./2236.13/63550544,%40+1/-/0,3/,/-54/3+-3-//*-6114640(6.2.04+$',/-.-,///+0)1.5140.1-(',$00*0-*10*/-,0--++1*,&',).-(/+21*-%""$)+1.--/,3/(63--+&,/-2542--4.+(1001142-+*)0/1(1/.(&-1,+1)0.*0(/0'54113..-.3426040/503+552*-41.0-0*-&*(0-0.2.202010.14040556524.+1/23(#-./1)33.-13)(&*$001//.+'$)-/0+1414/.5+55/005+,0+0-)-/1..)315/3-&0/.)21224)20,)6221&3/+$-3'%+41+*.1&31+0-*(+05150.,03(5212*4//4*--3'*.$-*/0%2-3/3300&.450/1/1012&*/543232'&.4),%*.4-.)3+430341,0.&+211352*+20$+32--44(*0)1)1-2.054+5404-3230/1./302/1/.210%101,/25/*)3440*+*.5652.-//53(3422231,(./15-4-110412226-,234*4..32-25.+-'.561/00563,)3--3/*.0.*000++&..0,),,+$$+.01.62./3/-4,)*0465-402.4/4*41..*,1544*(%-3.+-*,.30*00341,.4.,50513/.35).*1-+.*(024&+1/-)+)'/. @rCer/242/1998_57_CCS ATGGGGAAGTGAAGGTGGAAGCGGCAGCGGCTGCAGCAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + KJKKJ4E)HFEKHJIEIAA+F;@@CBD>G?E>@C1IECBIJJ>CG@KKJGCJHGE=HJGGJ?HKGEI?HDCIH:CF,;JKFBGHDFG?HKKDJHJJK=BA?GBJHJHIBKKK@FIIKJHC9EDD>JGIABDE=HEDKHE@AAA@GE:IDJHJEG3JHEBA=?KF@IIHAECG=KK>GGJFGHDBBK@DJEHJDJG/@JK>HFFKGHBC)I0KICEB=EH?JHKKEKKKJJICEIIIG?CEKBFKJCEHJH6IFGKCBK=G=9IGIIIBEFGJKKIFAKHHACFDJDHA>JKH2HIDD><59/8:6<&@?@:27&5,9====D;>EH5=;7<68E9:=<;A99BAEE7;9=EA?B?D:A3=/A>ACBAB@@9>8:<CA;A?:@8>>:>;>@?3C?@9A?DB/B9>5:@=G?DFGB>DEEE@65?GBDIFBEAB;32:<>:?C>>ED;54FA>H=>5;4>>=EEA@D9=CEB=/@<8GFBE=DD?>6>DFIFA@DDDFCF@GIGFHHGIGFGACFFD?D8?2=CB;5A<>GD;D8FDBHACDIE?DAHH>GGC@JFAG3><;GG.GD?6@3IEDG@B@(79B?0<<1AIEB6@@47@?;DDC@:=GFC@FHBG@DDIHB9>E>/I8?=,?A%?7HEG8?FF=AE?IECJBBCE@FGIA@HB9;?8AEA??43H=H@DB>E/BF=:AAD5-7>BA9?DEAD264;0$>=?+F;><>@:;=92?:@FC<@A6@=96AE9>83494DF<4><1?6;96CC4>I2@@?=>>A8=?<>>4&9;49?6HAIE:==>E>08@A/27=DB=78=-A8D;<:E@B@H@@JGEA5A=F5A:9>&.;;CC::;=BFGFBH5F>DFC<88DD7BDHIFGHEAC<==F<9B=DHD=E=CA0B:A>=6B8<H;7G>F@@C/DGIF>FDA&ECD8JHJ@=>=GG??>@:EIG6DA6;C(@G?EF8I;:5GHGDFE>>IIIJCCEED=CB?=;9@@8>5?70E?7>6?;>?D@=8><9,7@@H5>F@8;E>EE9>09FIFG>:C=BEC6=3;/:;37??CABFC<>2H>BE2DCF@D>=FD8HHBEAJFGD@862G451EIDG?FIHFC;G?E@9E8@BFF=:4GE?;A/@E?FGI0CFFC@?A+>B5?DEFGBBC?E5;@DFCCB?67AEBD@8D?>?>>;?;53BG?FBFF?B>EEFEC?E>?CCA;=B2C@C;9=7?>FEBDE@9E??;=/>>9;><==>?=89:>;:7:2(:929:997742,1724=;>8;>89871<689>7==>/;);616+4325<>::<<.0-0-:71;94710-62:5/:+2.65.672/7*178>4=;18718;<9;=/789:3;6=15;.18.<9,*0/7890=97/3;39<(;::::3989;79:767623:799672<85=<7<:8:2<=9=97=<575;4624;.769:9;57:7:<>8<3;7:9414999/61<>0:44890;<>9:=9>=15&73,;9<99258827:338<;>A3;=;>6:279=<:0/9097;:<9;=5=??:440::;?>>26<5<72943:87646:898=:?==:>9>;0>95=77<=27549(5,23:1:649+56-3;+*15/003-9+8:(=59871.1=;<,<-0:1.4160;9=;<3)63:==5;4;>=>>=>8=>=:<9?==:7680752:>:/=.;:89<.<<;)4)356:97;==09:><9>98<39<87<8-$89:9258;6;5/=,<8958>>6;7*5;=:;>/<95=:4?>99267>887$<2888<9<*3/-83/)3435:1121:9:9;;:44(&55:8.6078573:360.40226,68858::4666:8;9;689:2647:;:49860:9:80+298826(5-054/5:859867-4987899*42559848-43+24,4,2184931622;966:47::755&21275*776:://45298'/8;:6598195*.8::98999/,8541768487(,66;75-787875842;+3872:-678:3;8:74;;2756461-04-::8*9994625882289156/88:896:183929/98::2::9:/8273::5995;9398257::366:464;;8/-238*852:99-84,85;6:815:99931378958:8466798<0>5;=:84;/=;:;4;;5,:28;86=7>);:8:5:<7673<<><>88>66&(..08:096/5%*.:;=>8=8====7::960'99569;:?,::=;9??4;958;5<6==<=>7;.==635;:7<;=>>=9=>?=:;2;;=4?>;:3<347>8;39;<>:;9;8>;2===:=?3-85.7;;<26<.689=?;=<9?8<7=984518<=<99?8=2:8=7::?:7-:>>214,<>=>=:<;?>;=8:45=9?=?=?:<835<9;<>6<<::<==<7=65653;=:><;7>=9=>5<::898?>;;:<6:99=3793298=;98799=9?26<4:51=<;:9.47<5?<36:9==*7821:-9=;==>:<><7<:?818=0;/<64<>7;<729:5:?<=><=9;:6299;7<9:76;574-#;880.775/-5;6>/&25 @rCer/245/25_1432_CCS ATGGGGCTGTTCGCCTGCGTCGCTCCGGGAGCTGCCGACGGACGGAGCGCCCCCGCCCCGCCCGGCCGCCCGCCGCCGCCGCCATGCCCTTCTCCAACAGCCACAACGCGCTGAAGCTGCGCTTCCCCGCCGAGGACGAGTTCCCGGACCTGAGCGCCCACAACAACCACATGGCCAAGGTGCTGACCCCGAGCTGTACGCGGAGCTGCGCGCCAAGAGCACGCCGAGCGGCTTCACGCTGGACGACGTCATCCAGACAGGCGTGGACAACCCGGGCCACCCGTACATCATGACCGTGGGCTGCGTGGCGGGCGACGAGGAGTCCTACGACGTGTTCAAGGATCTCTTCGACCCATCATCGAGGACCGGCACGGCGGCTACAAGCCCAGCGATGAGCACAAGACCGACCTCACCCCGACAACCTGCAGGGCGGCGACGACCTGGACCCCAACTACGTGCTGAGCTCGCGGGTGCGCACGGGCCGCAGCATCCGCGGCTTCTGCCTGCCCCGCACTGCAGCGCGGGGAGCGCCGCGCCATCGAGAAGCTCGCGGTGGAAGCCCTGTCAGCCTGGACGGCGACCTGGCGGCCGGTACTACGCGCTCAAGAGCATGACGGAGGCGGAGCAGCAGCAGCTCATCGACGACCACTTCCTCTTCGACAAGCCCGTGTCACCTCTGCTGCTGGCCTCGGCATGGCCGCGACTGGCCCGACGCCCGCGGTATCTGGCACAATGACAATAAGACCTTCCTGGTGTGGGTCAACGAGGAGGATCACCTGCGGGTCATCTCCATGCAGAAGGGGGCAACATGAAGGAGGTGTTCACCCGCTTCTGCACCGGCCTCACCCAGATTGAAACTCTCTTCAAGTCTAAGAACTATGAGTTCATGTGGAACCCTCACCTGGGCTACATCCTCACCTGCCATCCAACCTGGGCACAGGGCTGCGGGCAGGAGTGCACATCAAGCTGCCCACCTGGGCAAGCATGAAAGTTCTCGGAGGTGCTTAAGCGGCTACGACTTCAGAAGCGAGGCACAGGCGGTGTGGACACGGCTGCAGTGGGCGGGGTCTTCGACGTCTCCAACGCTGACCGCCTGGGCTTCTCGGAGGTGGAGCTGGTGCAGATGGTGGTGGACGGAGTGAAGCTGCTCATCGAGATGGAGCAGCGGCTGGAGCAGGGCCAGGCCATCGACGACCTCATGCCTGCCCAGAAGTGAAGCCCGGCCCACACCCGACACCAGCCCTGCTGCTTCCTAACTTATTGCCTGGCAGTGCCACCATGCACCCTGATGTTCGCCGCCTGGCGAGCCCTTAGCCTTGCTGTAGAGACTTCGTCACCCTTGGTAGAGTTTATTTTTTTGATGGCTAAGATACTGCTGATGCTGAAATAAACTAGGGTTTTGGCCTG + 49%>9=9<81772+67.3=:455;;2326;898<9A=<25>@@8?6,26(47488-?9:=.=93<0;<.><8.>=:>=8>53B=;>+B<4A@=0=<:<=B8C><761=B:D?;?CA<3=%;=;=90ABB@?5@%<;A<5=83;:;=<25'=8D@CA@;8@AE4$69<;==:>9>?B?CB84A>@D3;?AE:=E66:32>-:<9@=D98BH:=E3DE3HE?G?6A?=;A<@E;B-GC?2IFFH8;FD2FD/E:>EFF=G;H>5<9BA>F>;-:FECF9@6@?9@0<89=*75;9=>24?>:C?;F+DC97;<@79?9EFEE@.ECG<7=84AC?593:A?B9:1/6;;4%(38?>@@29/9;>B?(@BF4AAB@CGCAEEDDD8?A5+684@;=5FF?=?>5D:9A3G;3<>B1@<.?C36B=9E?.13:BD1C?7A>+<=A=<%3<9;@=9:3=<:)29.AA;149<38?BD?F>=<;>5<6B@7@A+:;D7G4;811D8987@E<@?>4AA>E,GCA:=7D>=:;B@7?;*@??C>7C=;AFDDF@B7?AIHF8JA6BH7:K>J9H4BHK7KK4FFHII=IEEGGHJBC>:0KA:BE=5@?8;A8B@GI%KKFC7:2DC6GDB1JJKJ5HKJIAJJJ?JH@FJHJI'CDCEKIKEJJKEJGDDD;DKJCAEEJD@>@HH@@3CE?CIJI+HK:KDDKCKEIGJBH<@GKHDCIFCKK?+KJEI@KKKJ?KF*7J:K.JIKIKKI+KIEFKKK<=GKJHDKJGII+DIHDJC@EFH>8FH@6JKKJB&IC;KHK;D1CII @rCer/247/1486_71_CCS TCCAGCCAGGAGGGGTAATGCTGCAAGCCTCTTTGCCCTAGCATGGATGGCTGCCCGGGGGTGGCTCCCCAACCACTATCCATTATTCCGGCCATGTCCGGATCCCACCTCCACCATGTCTTGACTTCCCTCCCCCCAGCCCTCGTAGGATTCTCTCTGGCATGGAGGGCTACTCTGTGTTCGCATACCAAGCAGCAGCCACAGTGGCTCAGACTTCCCCGATTTGGAAACTCAAAGAGCTTACTTGCCATCTTCAGTTTCAGACTTTCCATCTCAGTCTCTATGACTTATAAGCCAGTTATGAGGTAGGGAGGGACTCATGTTCTTACCCGCCCCTTTCGCCTTGCACCCGCACATACCTATACTCTCTTTCCCATACCATCCAATTCCCACAGGCCCGTCATTTATCACGGGTTAAGCCTCCACCTATGGCTCGCACCTTACTAGAATTGCTGCGATCCCTCTCCCCCTTACAGTAACCTTCACCTATACATAGAAGGACAAGTTCGCAACTTTTGTCTCAGTTAGCTTCTTATGCTTGAAAACCCACTCCCTGGATTTATATAAGGCTTTCTCACCTCGCTAACAGAAGTCATATGTTTGTCAGTAGATGCTTTATATCTCCCCCCCTCACTTTTCCTCTCCCTCCCCCCCCGGCCTTTAAGCCTTGAAGTTGCCAATGATCACAAGAGCAAAAGACGTTTTTGTTCCAGGAATACATTGACTCTGTTTCTGCCTGCCTTTGTTTAACGCTCTTAGAGACAATTAGTGTCCTTGTAATCTTATATTTTTCATTCGTTGACTATATTTACTCTCTTTCGCGCCAGAAGGGCTATTGCTGCGCGCTCCGTCCGGGGGTGATCTCTGCGCTGTGGTATGAGAGAGGGCACCTGGGGAGACTGGTTGGGACCCGGACCGTTGGGAGCCTCTGGCGACTACGCAGCTGCCCTGTGCTCTTGCTTTCGTCTCCCGACACTTTTCTCGCCTTTGCCCCGGCCACCGGGCGTTCCCGTGTTTCCGGCCCTCTGGGGTCGACGCCCCTGTTGAAGAGTTGTTTCAGCTGTGTTCTTTGCGTTGTATGGGGATATCTTTTGCATATTTTCAGAGCTCTGCCTTTTTTTCCGATCTGAGATCCTGATCGCACTAATGTTGCTGGGTTTGTCGCGTAGAGTGTTGCAGGTGCAGGTGGAAAAAGCGGAACTCGAGCACTTTTGCTCTCGCTGGGACGTATGATGATTAAGTTCTCTCTTTTGTTTTTTTTATACGTGCGAGCGCCCGCAGCGGCGCGGCCTAGGACTCGGACTAGGAGTGACTCTTGCATTTAGCGGGTGTGGAGTTCTATCACGTTATTGTGAATCTCTTTTTTTAATTAAAAATACATACCCCATGGCAAGATTTAATATGAGGGAGAAAGG + .,-//+--,).)###-++".&.--,-/,././'*.'-,.././//+""-*///+-,.+(*)./+.%)**+,-++,.+%-#+$(*..).--(,..//.--.,&.-+*",,.,+%(',/..&.$.../%-%&*#('&'*-.&)+-,*(,&,--(-*))++'"**($,%++).-...--,&($)+-+,',-&+(/,*/').,-...(./,.*//../-$-+*,.'#+%.%.(*&..-&.+/()-%.(-$.+&&*.*)---.&%.//.,/&+-*//...//,+,"-,///,/&)+.$/,-//,$-".*-+-..)$+-%#.-/-//++#..(-,+(&)&&%&#)++$--$/,.-(%.-.&..-%++.---+,---(&**$,-+-+,.-,"-+)(*',...)(+(#')++#"#+*--(+).$-'('-.''.(-&,*.'.-**+-,-'$+,-),-)&%-(%',---***,*-)''(),$--.#.*++'*#---,--#-.-,*-,*-'-')+.-#,-,,+'*')),,%'',()#----(--(,),,)&-,'(%&$*---+++--+-,#)+**&*$-'+&"#$'#)##&%&%$'**...&.-%.,)-"%$+%)-//.-/.&/..$+",,.--#('&&&(,%$+,&((&'#**&&$#&&#%&%&+.%$%&%$.-/,&/)..,//*/+..*%#-/(....///-.%,+.*-*)$%)%)'',+,+&#)%*#'&)(,(,'*&%#$$)+&&$##%*$%--%)*'&,$#%&&$,(+''(%-%+*'+)%*-'))*$-++$,&+-&)'%(+&((,-$-($-%*+,(',+&,-,,(+*-(*$*--+"+&'()*&%*()+%(*(&,'$-,+(,%))',-#-,--..(-(+&(+&&###'&*&)#*%*'($$+'#%+(),#.*,#-)#())'-',,&-$&-#&%+&&%--.*,-'$,#,,))---+&(&-,+*+(&&%-*-)+.,..-'(*$+$((*$$$'(&+$)*'),#%#$,$###&$-*%%./)'*'-*.-$+('-)&$#+#')%$#%&,&&,#"#',,*$-'&.",.(.-&')#.'+'.-%),-%).%,+#-#".-(&$*.#,&&+()'&'%&&)#%())++%#(*-%(,&&##$&%)--.#,.'%),'$)-+(',(#'+%&-*-'-(-'-%-'+-'(-'.-)-"*-,-#.&#,)&,(,*&&("*'$%*.+-),)'**-)-)+(-'*),'%$&),)+-*%+,--",.(*.*-',%*-'')$('('%),*$"#($'),',)(--'---).%&&,)--),&),'+)%&,,,(,%*',(,+--,((-,--"--.(.#'''&&+&(%',,(,%)--'%,%'&&(,*')(#-,-#%-$'$#,('$''&'-%)$#%'.)$).'%%%#&*-%&%(+&(#,*++,.+)'$#(,,$&+$ @rCer/248/24_2033_CCS ATGGGGAGCCGAGCTGGGGCGCAGAGCGCGGGAGGCGGCGGCGGCGCGGAGCCCAGGTGGCTCCGCTGCCGGATGGAGTGTCCCAGTGTGCTGATGAAGCGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCCAGCAGCAACCGGGCCGCCCCCCAGGATGAGCTGCGGGGCAGGGCAGCAGCAGCAGCCAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCTGGAGGCCGATGGCCAAGAGGTCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGCGGTCCCAGGGTGGACTGGCAGCCGGAGGCAGCCTGGACATGAACGGACGCTGCATCTGCCATCCCTGCCCTACTCGCCCGTCGGCTCCCCTCAGTCCTCGCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCTGAAGGATGAAATTGGAAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAGAAGCTGATCCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCAGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAACCGCTCTCTGAAGACCAGGCCGTTTCTACTTCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTCATGGCGCCCGAGTCGCTCTCCGAGACTCGCAAGATCTTCTCTGGGAAGGCCTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATCCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAACCAACAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCGGGCCCCGCCCCCGGCTCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGG + /,$.,-.0055,551*/--,1*13220130440'13/53+30,4555).1('101)2,'3.11354'((0+)$.'0.0.+-$*-...-223/$&$)+/-*$56665322-/566:53,,,.67.%+,)(,-+')'%(1+)%*#'%*5(1&00084"-/12/(,8845866233./7211*13/2/3/97-(25567&43.:92'83277566443335/-55'.50&*3.2./838,-23,(/4463899+:6461:0+3,3(302-06239+.-,0+,&-*-$,+*-$23816::9124-2.132710%,42:-:5'.../.()&8679;5+8$47.1+8'--431-3+%14113.**)&---2(488,864&22::86'8648.0-.---%+-3558;:8)/-4,2595%+#)+22-69-.3433777806522+2.35/:756636.41-22936565499229945468%3*'/66.3/5+201327%/582299/,*363040/103..2#,.).155.473.-2/4+528865,*3.445962'3,,171'(7::687%5,50-3226384)+*503884401543/),.+.&201-1-.,-(,-1)565&1/004:33-1.*)-66546/1:3;7*;&;6>3=>:?6,09:9471=0:+2-.7=;068482>=3.85>-7;+;:22&<888-7871<>=2<47-+-824286/6749)65,22&20+,/3(622:/,,1./6-28<8332*793;225::>;79,:45&>6(<8+238;9>9;97;1.%',3*0258/:;9=>3:87(9,0(;)49:;94:6472-658269;7/<:0+/053$413;9:=<3?99<9<>8%854><;:2:6728:3-3012620381,-./4.529(324*4*$.,6872+*1/0*05(63206-11)-*5548-/5/4.77536826'-3+3,1021-+&)7:65(,5625&581:.524:8,32+0(.30/43/211(22.0/2024,4:72126331)02'('8,5)32:4453,236242-&42,2%45736445195,(466-0.,'*2++1.+,&.9.40836&612,5783-.,057/+2/..0-3,4//(**165/95.--*.8:90,$/132853%2-1432,2-013*-21)*23-5716222855350+',.1208,-&)2775365+48344846713839993.*),%134+0/091(01353:63.5$1416423+-4018.04578:65,.7/)500)-2/+((30(+0'.6070453:*2.*'15/9845213569--527-2+034,30+*19579:092631457)7635162/(+,-,-32-/+017/2*&0+43./0,044761//74-919-5585)/2336*/05154-511+473-%/,-3,87463484022)25.34/5/58879:755-6/5442,'524;2952560766787767/4.-635579365/34469386.2/+$/17../95534--/2(5822*-0,103/88=+:/2*-/7652$2:9>94'6.381==1956762-06/':;8325;386)=;7)486=1.7/88587831785256:-:<72)54=<JHJHFGKKKKJIJJAAE<@EKJJKCJJGKKIJIJKG2JKJ5KH>KKKKHJFFJJKB1KCIJEKKKKI8KKKJKJKHHJKKKKJIKKKKJI;KKKIKKJGJKJHIIBKGJ>KKKKGGJJHK=DC?JEH?KIBJAKKI>FKKKKKKHIIJEIHKGKKKBKIGDKKKKKKKKCKK;KKKKKKKKIFC2AKJKKKKKF?KHIE;HHKKKJJK8K;GEEGKK=KKKKIKKKKKICKKKJIHKKJGE:JI6JH=@JHK.GDBDKFIDICCGJJAKKK7KKGE@JJKJIFKKEJJKKEK=GHIKE2G9FIKKJKKKJKGKHKKKJJDJGD>JK:KKCJK=CI>GJKIFCIIKIDHIIKKKKKK<=FKHKFKE@DHKKHKKKK>JKKEEKKDKKKKKKKAKKJKKKKJJGAG6GCIKJIFJKJJIFIKH8@5DKKKKKKJKKKKCIJKKKKKIKEKDKKIKKKKKJKKJF>GGKKJIIKKJIIKCIGEJIFKJIGK=JKKKKJKKJKKKKGKJKK@JIGCJKHKHKKJKJKKCFCKJKKKKAKJIIJE?HBCKIJKCHFK>JGKJDKGJG?D=K?KK;GFKIKEJJHDKKKHHCJF9JKFKK*JIGJB99?EECKEKJKJKJKKHKKJKKCKKIIKKGKKADFKFK'KIKKKKHBKKKJIK?JKEK9KKKFJIKJHIHFC:KKJAAGHI>GJI/KIKH>KEJHKJJGIBAK2FKKCJKKDGJKK8>DJKJHJJGBJFJIJKBKKHHK=KKCCKBF;FHEBEKBH9FH1KGCHEBHEH9>C=I>GKHADJEGHE4GJGIAIFFB5?B>JEHHHK>ABAI>GABH:E4EGIH,;AEDFB,BGH9@DIF@E>=A:'?3?3A:D6>A8@@@C=+ABE?E>A:=%F?A:<;<<24CE?GHFCDDD<%??HIK-GEEHJGF4H@BBJFHFBJ3H?ACD@@<>@99=042FAGHJ=GAHJIDIFGGGID*GE=@D'DIH?HGIKGGFDC>@E @rCer/252/1943_63_CCS ATGGGCCCCTCCCTCCCCAGCCTTCCCCGCGAGCGGACGCGGCAGCGCCTCTGTCTCGCTTTTCTTATTTTTTCCCCCTTTCCCCTTTCTTTTTTTTTTTTTTTTTCTTTTCTTTTCCCCCTCCCCCCTTTCACCATTTCCTCTCGGAGGCGCTTCCCCGGGCAGGGCAGAGCCGGTCTCACCCCCCGCCTCTCCCGGCCCCCGCCGCCTATGGCTAGAGGAGCCCCCTCCCCACCCAAGCTCGAGCGGCGGCGGCCTCAGGCCGGGGGTCATCATGGAACTAATTCGCTGACCGACCCAGCACCCGCAGCCGTGCGTCCCGCTCGAGCGCCAGCGCCGGCGCCCCCGACCGCTTCCCCTCTTCTCCCTCCTCAATCGGCCCGTAGTCCCGCGCGCACCGCCGCCGCGCGCCGATGAGAATGAGGTGGTAACGGGCCCCGGATGACCCGCGTCACCACTGTGAGGCCTACAGCTCAGCCGGGGAGAGGAGGAGGAGGAAGAGGAGGAGAAGGTAGCTACATCAAGCTGGCTAGCAGGCAGATCCAAAGGATATCATGAAGTTTCCAGGGCCTTTGGAAAACCAGAGATTGTCTTTCCTGTTGGAAAAGGCAATCACTAGGGAAGCGCAGATGTGGAAAGTGAATGTGCGGAAAATGCCTTCAAATCAGAATGTTTCTCCATCCCAGAGAGATGAAGTAATTCAATGGCTGGCCAAACTCAAGTACCAATTCAACCTTTACCCAGAAACATTTGCTCTGGCTAGCAGTCTTTTGGACAGGTTTTTAGCTACCGTAAAGGCTCATCCAAAATACTTGAGTTGTATTGCAATCAGCTGTTTTTTCCTAGCTGCCAAGACTGTTGAGGAAGATGAGAGAATTCCAGTACTAAAGGTATTGGCAAGAGACAGTTTCTGTGGATGTTCCTCATCTGAAATTTTGAGAATGGAGAGAATTATTCTGGATAAGTTGAATTGGGATCTTCACACAGCCACACCATTGGATTTCTTCATATTTTCCATGCTATTGCGGTATCAACTAGGCCTCAGTTACTTTTCAGTTTGCCCAAATTGAGCCCATCTCAACATTTGGCAGTCCTTACCAAGCAACTACTTCACTGTATGGCCTGCAACCAACTTCTGCAATTCAGAGGATCCATGCTTGCTCTGGCCATGGTTAGTCTGGAAATGGAGAAACTTATTCCTAATTGGCTTTCTCTTACAATTGAACTGCTTCAGAAAGCACAGATGGATAGCTCCCAGTTGATCCACTGTCGGGAGCTTGTGGCACATCACCTTTCTACTCTGCAGTCTTCCCTGCCTCTAAATTCCGTTTATGTCTACCGTCCCCTCAAGCACACCCTGGTGACCTGTGACAAAGGAGTGTTCAGATTACATCCCTCCTCTGTCCCAGGCCCAGACTTCTCCAAGGACAACAGCAAGCCAGAAGTGCCAGTCAGAGGTACAGCAGCCTTTTACCATCATCTCCCAGCTGCCAGTGGGTGCAAGCAGACCTCTGCTAAACGCAAAGTAGAGGAAATGGAAGTGGATGACTTCTATGATGGAATCAAACGGCTCTATAATGAAGATAATGTCTCAGAAAATGTGGGTTCTGTGTGTGGCACTGATTATCAAGACAAGAGGGACATGCTTCCCCTTGTCCACCTTTGCAGCTGTTTCTGTCATGTAGTTTCAACAAGTGTTACCTTTGAGTGTAAACTAAGGTAGACTACTCTGGAATGAGACATGCAAAATCAGGAAAGGCTGTAGAAGGATATATACCTTAACAGGCTGATTTGGAGTGAGCCAGAAAAAAAAAAAAAAAAAAAAAAACTACTCTCATTATTTGTGTGGCTAATTATAATTCAGTGTTATTTAAACACAT + >9DA>?=;DDAC6C8B:,7AFFFFEFFDECBBBD?'@ABB?@&@C>?90:@.?:;<+;=>;=3*D=C?A<>BDECC&;<68519<'1276=?$:?903$77@;;:295>B+<5:AA=-4>0D;B@A@4CF==B:B=?AA?@A4AD@B2BACFB3@7BE:,7?5FCD.CDB:>>3D:<<9C>-;@>.3DBGC?<6%CB=%:5:DD=B9%:?@>:=BBBA>;<8ED88.@DDA?A>>2;?99@7$0&08'8;.=505-+;+96A:7A:>-<568355:06:.3BD7=?+@9BB?:@5?;@>>8-=A4D7@C>B6BBB2<6C@BB>C;9?8BA5FCFAB*D>;74@5@GDF?B>5=;C3@@D?>=E?CAFAGF?7>=@:DBCG?BE>2AF@D=AD7?97F=FBEGBF8?::'B2ED=CBCCB?,CA=A8E=GDEG>EB2EC@AD8CAD5A>?A?@$=>DDAE@E6@E?FCC@??@DB.A?BF@>9.=3C5-CD=BFE?E@AB;@>@A=0:@@1>@>D@E9;>,;<:;?>>EF7@DF0AA??@@??B<9:C;D;9=9=6C69BB6DC56CAD9@8115=E:AD<>@=FCB?=:A9B=4C96@CAB0=@@C6E;=A@@><;:CBA)AFA=GG=B4@C@=6>C1<.@>==>1?77=;69.@@C:86<>AA7>??9274;?>A:A4@B6@6@??3@??;:>>C:@<;:>.A??>@=-B9;783A1::::05%>C::?7=@??59@9:@9>38=-<87<=;;295972>;6<;712<;>?:63:>@@A8<C=>;@@5/3<<9>==>7=9><:<9>;=:B=A5:19@?4:7#:?<:?<><>>B3<;A;@<7==@13.B<=979?;@AA,?@5C<9==;8A232=6B0719897918<<9::9637)6;6<*3:038<9<8.=?>=;<8=898806<8><:78.0/<&=5<33=6;=>:9773;<49=7-897745>>9>>*1589?85/14.=:;=4==4:4===5477<<=;;7=261110=17078';:68'789:3)'6>79:==7=9861448<::53;<<=/83:4860089?;9.<5=79&/535*=:2=72:6<8-1+242;7689'7.030)77235)6881(5:8927<<0105:8257417?66849:55/53002+**414323&+22/51243977110859'3.2734'./0/30:6&;>>=7=:04/3971450(:163979171+:751::;)778;;?9?54;:><4<.8:77<<;:8:<:9:;<;;;:8846$;7:<;9-5386=8;26,6>=;>>;>?836:;:7>;:-881;>?56<5,390? @rCer/253/0_862_CCS GCAGTAGACGAGCAGCTCGGCCCCAACCACCCTGGAACAGTTACAGAAACTTTCTCCAGTATTCAAGAAAGATGGAACTGTCACTGCAGGGAATGCATCGGGGATAGCGATGGTGCTGGAGCTGTTATTATAGTAAGATGCTGTTAAGAAAGCATAACTTCACACCACTCGGCAAGATTGTGGGCTACTTTGTATCTGGATGTGATCCCTCTATCATGGGTATTGGTCCTGTCCCTGCTATCAGTGGAGCACTGAAGAAAGCAGGACTGAGTCTTAAGGACAATGGATTTGGTAGAGGTCATTGAAGCTTTTGCTCCCCAGTACTTGGCTGTTGAGAAGAGTTTGGATCTTGACATAAGTAAAACCAATGTGAATGGAGGAGCCATTGCTTTGGGTCACCCACTGGAGGAATCTGGATCAAGAATTACTGCACACCTGGTTCATGAATTAAGACGTCGAGGTGGAAAAATATGCCATTGGATCAGCTTGCATTGGAGGCGGCCAAGGTATTTGCTGTCATCATTCAGAGCACAGCCTGAAGAGACCAGTGAGCTCACTGTGACCCACTCTTACTCTGCTGGCCAGGCCACAGTAAAACAAGTGACCTTCAGAGCAGCTGCCACAACTGGCCATGCCCTGCCATTGAAACAGCGATTGCATTTGATCAAGCCATGGTGACACAAAATACACTTGATCATCAATAGGAGCCCATGCTAGAAGTACATTCTCTCAGATTTGTACCAGTGAAATATGATTTCTGAACTAAAGAAGACATTAAAAGAAATTGTATTCTTGCCAAGTAACCACCACTTCTGCCTAGGTAATATGATTATAAGGAAATCAAATAAATGTTGCCTTAACT + S$&#%,($#()+,'$*#&%%%,*,$'(),,*,)',#&&$*)-+*,---*-%$!##(-+-))%&&&()%)+')'),**,,(+)),(((++..-.,-)&+-(()%&),($#*,$&%''&%''*&*,&.+'""#%#%"')((,(00-1'+)#%))+/0(/*..++',(''*("$+&%*))#$/)(,/(--1,++'++-0/,/,11./+/+1-,1/(*#(+(,,/*+.))&#(.---20/)101.*,-./2.,,-,&'$,,..0/,&))-&&,+..-)&%%(,01(/+(,.$*&*-,,15'1/($$')%+16*44654-&--+(+)16%*.;569011/0/:6944<=::776139:821(20,&+01284695767<628799/4-533577)53/47351&$'222*/1(3%,5:48:-7>683('/6;:<69<::516242:16)0174:48<:,=.54:50*),#-0-'&'$(&(1454:/9:2<1,/05,687:86;32>3:/73874'425<-(*.437138457502-.&02499-9916477<921458<009;,5*,555-/3-*,/12-'14((2293+')51)-47-5//2-00243020662+++2163.'(.)/%*146122()**+1/4-$'(./)1-/).23125.26.654203*5,,32-260/.,/,%//3++12#&433,,+.#%443+-&6'113-335..+5-.02305602+4346&5.*03)-8:03(4/--065*:98692154(9991:+<>7**%244::><-956=3:6<=;:?9@=88?5:2)91;8553315'68==:>54.,*33-8)7868?=59,:85(42361958;238?53 @rCer/255/24_2327_CCS TGGTGTAATTCAGCAGACCTTCACTGGGCACCTGTGATGGGCCAGGCCCTGTGCCAGCAACAGGGAAGGGAGATGAACAAGGCACGTTTCCTGACCATGAGGAGCTCTTGGCCTGTCCCTTTTGCAGTGTTGGGAGCTGTGCACAAGCAGTCAGGACTTTGGGACAGAAGTTTAGTTTAGGGAGCAGGATAACTGCTTTGACAGCTACCCACCCTAAGTCAGATGACAGGTGTAATTCTGGAGGCCCTGACAAGTATCACTGAGGCAGGCCGAGGAGCTCTCCAGGGAAGTGGGCATGTTCCCTGAATCTTCCTCACTTCTAATCAAGGCTGACTCAGTTCACTTACGGAATGAAAGCCAGTCACCCTGCCACTGGCAGAAATAACATGGTGACAGTCGAGATTCAGAGAAAATAAGACAGAAGCAGTCCTTTTGTAAACCCTGACCCAATGTATGCCTACGTCTATCATACTCACCTCTGATGTCTTGACACGTCTGGGAAGGCCTTCTCCAGCTTCCTGGAGCCCACCCTTTAAGCCGTGGGACTCCCTGTGTCTCATCCATGGGAAGTTCCAAGAAGCCCAGCATGGCCATCAGTGGGACTTCAGGTAGACTTTGTCCTGTAGCCCCCACTTCGCCCTAAGCTCCCCAGCATCCTGTCTACCTGTCTGTGGAGTCCGCCTTTGCTTTTTCCTTGCAGGGAAGAAGGTCCCCTTTGTGTCACTCACCTCCCCAGGCTCAGAGTCCCAAGGCCCTGGGGTTCCAACTCACTGTGCGTCTCCTCCACACAGACCAGCAGGTCCTCCTGTGCTGACTCCAGGTTGCTTCACACTGGGAGGGTGGTTGGAGCTTCACACACCTAAGGTCTTGTGCTTAACAGTTTAAAGGAAAGTCCTTGTTGAGCAGAACTAAGTTCACAGGGAAAGGTACACACATTCCTCTCTCTTTCTCTGTCTATCTATCTAGTTTCCCCAGCTTGGAGAGCCTTTCCCTTTGCTTCTTTTCTGAGCCACATAAGCTTAGAAGAAAAGTCCTAAACCAAGAATACGGTCCTTGGCCACAAAACAGGGCCTGATCCCCCATCAGAGCTATCTGAGCCTGCCTGCCTGGGCACCTGCTGCAACCATGCAGCTACCCTGCCAGGGCGCTCACCACACAGAACCGCAGGGCCCAGGAGGCATTCCACACAGGCACTGGCCCCAGGCGATAGCCACAAGAAGCCTAGAGCAGGAAGCAGAAGGAAATGCTAACGAGATCACACACAGCTTCATGGTGGGTGCGGTGGGGGTGGCTGGGCTCTCCCAGGACAGAGGGGACTCTGAGGTTGGCAAGGCTCTCCCCACTCAGCCTCATGGTCCCTTATCTCCTATTTTACACTATTTCCCTCTTGAGAAAATACGTGCTTTCCGGATGTATTAGAAATGCATGAGCTCACCGAGTCTACAATAAAGTTTGAAATTTAACTGCAAGGAATTAGAAGCATATTTGCAATCATTGCAGCTTCTTCTTTCTTCTGCTCATAAAAGGAGGGAACACTAGATAGAGGGCAAATATATCTGAAAACCTAATTTCTTTCTTTTTTGATAAGGAAAATCTTTTCCCATCTCCATCCATAACATGCATCAACCCGTGAAAGAGATTGTTTCTATAGTAACTGGTCTGCGATCTTTTGTGGCCAAGAGAATAGCAGGCAAGAATTAGGGCCATGACAGAATTTCCACGAAGCTCTGAGAACATGTTTGTTTCGAATGTCTCAGTTCCTCTTTGTCCTCATTGTGTACGATCTGTCCCCATCCTTCACTCCTCCCAAAGCTCACACCAATTTTGGTTGGCACAGGCACGGAGCTGGTCCCCTATTAAGTGGCATTTATGTTAACAAAAAATAGTTCAGAATATCAGCCTTTTTCATTGTGTCATCAAAACAGCTTAAGAGGGGACTACTGCCAATGTCCTCTAGTCTGACCTCCACCCAGGGAGACCCATGCAGCCTTTTTCAACTTTCTGATTCATGGAAATGACCTTGTGCAGCTTTTCCCACCTCCTAAGTGTTTCTGCATCTGTTCCTTCCTTTGGACCTCACAACAAATCCTGTGAAGTAACTGAGACATCTGTTGTTAGACACATTTTTGTGATGAGTAAACTGAGGCTTGGTGATTCTATGTCTTGTTCAGAGTCATTAAATGTATAGACAAGCCCAGACTCCCCAGTTCCACTCCTGGTCAGGATTCTACTTAGGGGTCAGTATGCACCTAACAGACACTGCTGCAAACCTACTATGTGCTAAGCATTCTACCAACGGCTGT + "$&'('$+),*'')*'&))-.,(%'%+'%$&%'*,+,'+-.,*+*,+-.,($+,.--*,.)%$)*',&-,'#%++---+.'-(,-+*-)$)),-(.)')*(-,)++*'*(-')+,'),-$()%*,)*&**-)-,(,)''+,)+((''((*,--*)**).,$,+')(,'+))+++()#+,,-++$)*()()*-"%)+$*((&+,+%),)-,+(+*%',,--,&())%''')&'&'*)-)')+%#%%&+,(&(*-+-,-+)&+,&&-','*&(*'%+()(,,')'%'-,'*)&&-+'%,*$,&)(,-),)-,-+.---,)+)&'+(-,,#'*),-+*,,)--**-,-*--.'-','-,,,(&+',(%*')'#')(($+(),#&)+,.--,%-%%*-,-)-+--,+,*-+*)'-,),+-,+(++)*+)*(++,)+++-,(,-,-,)((&+**)(,,')'',,'#&+-)+'()()(%*+,-)'+,*&&'(&"')),++(*&#*&&('-(*+-+++,-+,+,)-,(-&'(+-,(*+#%#$%%&&((&)*'"##')'*'*(%&,-*,-*)$)+%+)(+&)&(+--('+'$)%+)+,#*)),+('(-++,(',*#+(,)%#(,,))'%-,(+(())))))()($(&)&())(''&))%'&($()%('&$%#%$#%&($%$$%&'&)&')&))(#"&&&)'&$(('($))%'%')&)('($%$%(((&((&&&&&')'%'&''$%%(($&%$$$&%#%#%$)(%%('&%%')()''&)(''&%&(%()()'())))'()'(&'((#&(%')%()''(%$$%''''('$'%%%'(((%((&%%''&$%$%$''&(('('''((('$%%$%('##$&%%$&((()%(%%%"$&#'%#$"((('%$%))())('$#'('&($''"&'$((()&$$&%($&&(&((&')$##&%%''$%%&%&$%"$$%$##%"$#$$%%&#%$%&($'&#'&&'(%(()'()'#'&$$#%$#&'(('%#"#&''%'')(%$%&(&)($('(%(%&&()&%('&)()(&#(,'+,$*'-$%*+$)++*(*..,*),&+%,(*,,)'&*(+,'),--)+)')&)&((($'&%'+++,.-,&++(+-'*(','*(,*(#"$&*(-+%++)+**)*(,$**+)*,-$+,+'$)*)--''+(+.-,)+&-'(*+(),,)'#$%&+*(,),+,,-+-+,*)-.,*)''&&(++*$+)-'*+--+',','-(,-+%'(-+'))+------*'$*'+,+)*.-*-+',)(,+%(&()&)-**#,,(+,,&%-+&,*&%(*%)(+*()*-+-*($(&+*'+)((+'(%),-,,,(&((+)#)('+(,*-)-'%&+)+'*%+)((+*')((,+'++'+(+,,-)++)++')'('#(+*+,-)++(',.(+(,+))-*,--)$&&&'((&(*,+%'#-%#--,%*++$)''*)&*%+-,*-&$$')*'*%,,(+)$#)%'%)-'(,(-,,+-'(-%%)&&)(')+(+*)),+)#&'($&&(,++-),(#)+,'(-+((-+'++)(+'#%&)%+,+)*((+&,--,.-'%)-,+(&('&%&($*'**('+--$(+(+,,('&''(#%&'%%$(#%"%%,+-.---(+(,*$()-+(-,-',,((-)-())*+--,()--+$+(&)'%)(+,,'(*-.-+),&$*)#'&%(&-,,.-(**--*(*+%(&(,(*'(-)-#('))'&*+*-,)(((+,',,+*,-,(('',&$%,&+,,)--,+(&()()--++-(%&)-----)*..,'*.--*+,+)(($*++..+(**%)'((&*#$"$%$"%##&&#&&(&',,-')*+%'$#*($'*",',',&,&#%('(('%''()$(),,*$*,%-,,)(-+&),((&('((-.('*(,(+(-+-,$+*+,,*-,-)-+%"$+)+--++,,,.)-+#()**&#*-+((,-()',.,)*+)$*)($%%''((&'%#$'#$))&%$((%+('&&'(&"$))%#"'(&)'*(,+-,-+-,(+),')'+)--,-'$)()$%**,*(&((-**&'(,+,(-))-'*(%$&%+*(''$(*+,-++#*--+''*'(,,,,,')---)--+-)+*+(++&++%))(&'*&&,))--,,((+-+&)%+++)+-,'&(*)&(.+(-*('(,(+'(+&)+'*&,+)(*)(-+&&%'))++*',+)*+,,+,(+)+*)+$"%(*$%(*(++('+()--*(%""#""$('(,+-,+(&())&$'((**--*,++-*,&$*)$''+++%)-&'(',+*(&,,&&) @rCer/256/1970_54_CCS ATGGGGGCTGCGCTCGTGGCCGGGCCGGGCGGGGAGGCCGGTCCGCGGGCGGGGCAGGGGCGGCTCCGCGCTTCTCCCGCCGCCGCCGCCAAGGGGAGTTTCCAGGAAGTGGCCATATTGGATCCATTCAGCCGCAGCCGCCCGGGCGGAGCGCGTCCCGCAGCCGGCTGGTCCCCGTCGCGGCCCCTGCGCTGGTCCCAGCCCGCCCGCCCGGTGCGGAGCTCGCCATGGCGGCCACCGACCTGGAGCGCTTCTCGAATGCAGAGCCAGAGCCCCGGAGCCTCTCCCTGGGCGGCCATGTGGGTTTTGACAGCCTCCCCGACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGAGACTGGCATTGGCAAATCCACACTGATGAACACGCTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGAGATCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCTGAAGTCCCTGGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATTATTCCCATCATCGCCAAGGCTGATACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCCACGGATGACGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGCAGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCTGGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGGAATTCCTGAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAACGCCGGGAACTGGAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTGAGGAAGGACAAGGACAAGAAGAAAGCCAGTGGCTGGTCTTCCATTTACAGTGTCACTATTCCCTGATGGAGCTGTTATGTGCCGCTCCAGTGAAGGCCCCAGCCGGGATGCTAGGCCTAATAGTTCAGCGTGGAGATGGCAACTCACGTGGTGCCCTAGGTGCAGCTGCGTGGTCTGGTATACATGCTGCAAAATTCACCCAGTTCCCTCATTTTAATTTTTCTAACCTAGAGCTTAATTTTAATAACTTTAAAACACTTCTAAATATTTATTTTGGCACCAGCATCAAGACAAATAATATCCTCTCCCATTATTTTCATAAGTAACACAGATTTCCTGATTTTAAAAACTAAAAAATACTGCTAAACCTTTCTTATGTATAAAGTATGCCTATCATATACAGGAGAGGTGGGTAATAAACTTCCTGTAATG + CJJFKK-KJKKKKJIK@KDKCKK/K;KK=KKKK9JK/KAK9JK#?IDE4FDHK%JIKKK+KKKFIIJKK$AKEKKKK/KKKKKKKKIKK>K8KKK8GIKKFK4JJDK>KKKJK?JKKKGJKK>KBFIKKJKKI7KKKKKK38JK$KKKI>JK=DKK*KCKK5KJK;KKK3K:=FKKJJIKKJJKEIKKKKKHK>JKDKKJ?IKKIKKKKKGE:KKKH3JKHIIJKAEHIKKKKCKGJIKAKKKKK5IKK&JKKKK)JJJKJKKKKIK=DKKBKKGKJKKKKKKHHI>KGK?KKCKCKJJ3DK5KKKK2KKKGJGKKHIKKJKKKKHKKJKJJHHGH*CK=KKKK1KKJJJKJKJKKHJKKBKIKKKKKKKKIK4KKKBJKKBJKBKK;F9KKKKKKHKKKKKKKKKKEJKKJKJ;GJKKKIKGKKKFKKJJJK3KJKKKKCKKK4GKAGHK?KHKBHK+K9KK=KK/K7KKFKKKKKKK:IHKKIKK5HJKK4GKKK>HJJJKEFFEJKKKKK?GGIK(K9KJFI1HEHK+@J=GJHKI6JIK4KKKIIKKFK@K6KGKGK5KKKF@KKJJKIFIJKJ1J)K=EK%K3K5DJKIKJKHKICKK>KKKK?KJKCKJ>KGHCICJKBGG=AJKKBK5JKK*KCKKDGJJJDK9K7JAIKJEKFHI7HJ?KKIJKKKIEKGKJHEG?K9KKKFIKCJK5F:KJIKIGGJJG$JJKI=K5KCKKJGI>JKKDJK>KKK7KKIKKKKDFIK6DIK0J9BJKDKJ0HIKD@KFH;K=KK2GKIFJDGEKKKK7KKKJJK9I5?J&DGKJKBJ7KKK6B=K-KKBKJKKIIJ@K=KKFKKKJ@HKJKHKKJKCIJKBKKDGJH0KKIK?F@KK(GEK(KIKIJIJKJKJKJJG8KFHGGDKHKKK?KKKKK6K?DKKK7GGA'IK$JKJJJI(K=KKKK0JHH;K0JIKKKJKCKGKKD,I5IKJ @rCer/262/0_1851_CCS TGGGGCTTTTCAGGGCGCTGAGTGGTTTTTCGGATCATGTCTGGTGGCTCCGCGGATTATAACAGAGAACATGGCGGCCCAGAGGGAATGGACCCGTTGGTGTCATCGAGAGCAACTGGAATGAGATTGTTGATAACTTTGATGATATGAATTTAAAGGAGTCTCTTCTTCGTGGCATCTATGCTTACGGTTTTGAGAAGCCTTCCGCTATTCAGCAGAGAGCTATTATTCCCTGTATTAAAGGGTATTGATGTGATTGCTCAAGCTCAGTCAGGTACTGGCAGACGCCACATTTGCTATTTCCATCTGCAACAGTTGGAGATTGGTTCAGGACCCAAGCTAGTATTGGCCCCACCAGGAACTGGCTCCAGATCCAAAGGTATTCTGGCATTGGAGACGTATATGGGAGCAATTGTCATGCCTGCATTGGTGGAACAAATGTTCGAAATGAAATGCAAAACTGCAGGCCGAAGCACCACATATTGTTGTTGGTACACCTGGAGAGTTTTTGATATGTTAAACAGAAGATATCTTTCTCCAAAATGGATCAAAATGTTTGTTTTGGATGAAGCAGATGAAATGTTGAGCCGTGGTTTAAGGATCAAATCTATGAGATTTTCCAAAAAACTAAAATACAAGTATTCAGGTTGTGTTGCTTTCTGCCACAATGCCAACTGATGTGTTGGAAGTGACCAAAAATTCATGAGAGATCCAATTCGAATTCTGGTGAAAAAGGAGAATTGACCCTTGAAGAATCAAACAGTTTTATATTAATGTTGAGAGAGAGGAATGGAAGTTGGATACACTTTGTGACTTGTACGAGACACTGACCATTACGCAAGCTGTTATTTTCTCAATACAAGGCGCAAGGTGGACTGGCTGACTGAGAAATGCATGCCAGAGACTTCACAGTTTCTGCTCTGCATGGTGACATGGACCAGAAGGAGAGAGATGTTATCATGAGGGAATCCGGTCAGGGTCAAGGTCGTGTTCTGATCACTACTGACTTGTTGGCTCGCGGGATTGATGTGCACAAGTGTCTTTGGTTATAAATTATGATCTACCTACCAATCGTGAAAACTATATTCACAGAATTGCAGAGGGGTCGATTTGGGAGGAAAGGTGTGGCTATAAACTTTGTTACTGAAGAAGACAAGAGGATTCTTCGTGACATTGAGACTTTCTACAATACTACAGTGGAGGAGATGCCCATGAATGTGGCTGACCTTATTTAATTCCTGGGATGAGAGTTTTGGATGCAGTGCTCGCTGTTGCTGAATAGGCGATCACAACGTGGCATTGTGCTTCTTTCTTTGGGAATATTTGAATCTTGTCTCAATGCTCATAACGGATCAGAAATACAGATTTTGATAGCAAAGCGACATTAGTCGTGAGCTCTTGTGAGGAAATCATTGGCTTTATCCTCTTTAGAGTTAGACTGTTGGGGTGGGTATAAAAGATGGGGTCTGTAAAATCTTTCTTTCTTAGAAATTATTTCCTATTCTGTAGAAAATGGTTGTATTAGATGTTCTCTATCATTTATAATATACTTGTGGACTAAAGATATAAGTGCCTGTATAAAAATCAGCCAATTATGTTAAACTAGCATATCTGCCTTTATTGTGTTTGTCATAGCCTGAGTAGAAGGCCTTTATTAATTTTTTTAGAAAGCTTTGAATGCATTTTGTTTGGTATTGTATTTATTCAATAAAGTATTTAATTAGTGCTAAGTGTGAACTGGACCTGTTGCTAAGCCCCAGCAGCATCATCCTAGGTAGGGTTTAATCCCCAGTAATTGCCATATTGCAATGTCTTAATGAAGTTTGAATGTTAAATAATTGTATATCACTT + S##&&""%''%""""#%$%$"%%&(#('''&&%'(''&'(($('$%'#&%)(&')&'%#(%'&&&#$#&$'''(#&(&('$%%&))(&%()%$&&#!$$'(()(('''$(%((#%%'()%(((%(%()(%&$&'&)%&))%%%&$(')((('))#&'')$'('$#$''$$%&$%(')))((%(&&($%')%)))'%(()$')%)()(&$%#&'(($''&'(($('%((#%&))(&#&&(#&&'('##%''%#%%($$%((&#"%%(((''((%$%+*'()(+$((($%(($('),+)*'+)('(&$#&%&$'($&))()('%')$#')'$###"$&$"#"#%'%#%(&$"%%$"#($&)$#$%&)%(%#$&$&#&$##%)%#'&%(&)#$$(%(''""#'%'$%$()%)*))$./01)&*..(+'((&#%*,+)-$$-*)+,,11*/10112.+/0%+-+*(-1,+*$,110,)+$%#&)*+(-*),-&,*0,+.++/.%0',)*+0,12,)*-%&)0%/./(*),'+*(,+,111101*0/+.*.),0,1,1,0&.,*(.1/-1*,0-101.,-./)10()),&+)(%//$."+,),&-*-(-.//0&,-1-+/)11102%0///**,%.00/(&**,0*+-0-,0*)00,,000*/.)00&.,.&-+1,-'00,/+*0.,,0+1+0/./+//$00+0#'*(1010%,11-0,+$-0.).'-'+-0,,)/,01&'&&)0&,-)%.0,1,&'&)/--,/000.+-0+-,,'.&+00(.,+*&../.,0,200*/00-0-0/--*'+*.10-+&)$-.++-*-+',*.10'+.1-/.+*0',,,.-&-*$/--#$,'.00,+.+001-,-/2+-0,&,+-(/)&))*+*#(-+011-+%0/.+1*&,0-*+01&/+)(),++110,($*+-111,+(-+--**.+.+&000-.+/,..&/..+-%..+)$$(+10-().+%.)/%%'/.1-,,+',**+%*-0,011*&.+$.+1&010+),,--./+*)&,(#(((,.)+/*-..)+211&+,'/+(1*()**,'/-.1*.))-1/&//.').*0*0-0-/,00'(%*+-,&,++/11,%-.,210,1*1.(.,./.2-&-+-220%)./+/0/+1.0.'1111-1/',.0,/,'-*./,./'#0-)**(,110)(*&+-1.-/1+--&-102,)(,/&+-,01-,&-'-2,+,.*-...,01)0,0+0-,010-/&+'0&022,-%'*1*+-'0,01-.1120..1)/,0/,00-&,10&.$+'#%*,-0.,,**.*(-)-&,0&/002//&--++111)1/+-*,.2,'+110-,,(*,+,0./%'+)-1110&/.,+&$(,,&'*',-',/')(/()/,*,),+),-*,-+).)*($,((,,.-),-(*)--+$*+%$%,*-,)-,-,'+&-)%)(**'('$&+#$('$)('+,%,-&),+++)--,(,-&$+')'+&$-*%')%,,&$----)+*$(*+,+.%*-,,'*+),(+&,*&('*-)'&+$$)*)(((&%$',)-,+))$)&"$%((+*,*+#)*'#&(#%*+)*(')+-&)'%+($&&$(&)+&()),+&*--))),-,(-+)+,,-)+(*#),*&)(&()#%$($(,-&,,&#%$+&)+*-+,,((--*+#)-,%+,),,%,***'--(,,)',*-,,--,'&(*..-.21/+#'$#)%*'')&0&$*-)%&%$+/-(-,(+)&%*',++--))**(('$((&(%))(())*.-'&))'-,)+(%,+)+))&++,,'))*&&)&)&$((&+$(),*(',((,+,'+,-,-',)$$+&')(+()$$)),. @rCer/264/1756_55_CCS GGACGCGTCCGCCCGCGAGCACAGAGCCTCGCCTTTTGCCGCCTCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGCGACGATGCCCCCCGGCCGTCTCCCTCCATCGTGGGCGCCAGCAACCAGGGCGATGGGGCATGGGTCAGAAGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGCGACATGGAGAAGATCTGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCGTGCTGTGACCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCAGCCATGTACGTGCCATCCAGGCTGTGCTGTCCTGTACGCCTCTGGCGTACAACTGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAATGGCCACGCGGCTTCCAGCTCCTCCTGGAGAAAGCTACGAGCTGCCCGATGGCCAGGTCATCCCATTGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCACCTTCCTTCCTGGCATGGAGTCCTGTGCATCACGAAACTACCTTCAACTCATCATGAAGGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCAGCACGATGAAGATCAAGATCATTGCTCTCCTGAGCGCAAGTACTCTGTGTGGATCGCGGCTCCATCCTGGCTCGCTGTCACTTCCAGCAGATGTGGATCACAAGAGAGGATATGACGAGTCTGGCCTTCATCGTCCACCGCAATGCTTCTAGGCGACTGTGACTTAGTTGCGTACACCCTTTTTGACAAACTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGATTTAAAAGGAACGGTGAGGTGACGCAGTCGGTTGGAGCGAGCATCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTCTTGTTCTCTTTTTTAATAGTCATTCCAATATGAGATGCATTGTTACGGAAGTCCTTGCCCTCTAAAAGCACCCACTTTCTCTAAGGAGAATGGCCAGTCCTCTCCCGAGTCACACGGGAGTGATAGCATGCTTCGTGTAAATTAGTAATGCAAAATTTTTTATTCTTGCCTTAATACTTTTTATTTTGTTTTATTTTGATAATGAGCCTTCACCCCTCTTTTTGTCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGCAGCCAGGGCTTACCTGTACACTGGACTGAGACCAGTTGAATAAAATGCACACCTTACAAATG + (#'$%#%'$$"&&%'$('%((('%&%(('%%%%)'(&')'%%&$)((&$'%$#$'(&))())'((%($($%#(#$$(&(&%''#$&%'%%$#&($((('+(%')*((-,-+),*.'--/'&''&&(&.%-+2.'2/1,,1,,%(/.&*0/+*.+$-$%',-,&&,&---+&0/'..*%'.)'$-)#0.0/.&$$,(,$-%.*)-,+/,&*,&$..&01+*'&(,*$-,&.1'$$21&-110/4-/1400%&(+(-/.-,%,(3++%(*+1'002.0('*-5-+14150531*3%3).&"+-562/.$$$/&314.,+*.0(-*,1-)&().3322532*+(*,20-/+.//*50340-%&'34-2.212$$41+/-(-,2010(-36/164+1-1'3(3+/*/.,(0&/-.+16214//+0.+003-.3//-%+&/5+(,,-'++-+4,4+//10$',6032+.)52411'-++,#04100%(*.,-*&#)-/(&&-$$00.1(,02,/02,-2/0(354/0$%%-2123+/10.,0+,4'/2/&02+0442(3/.*46143222%,/42/('/*++/,')-/---$)-'#-.62//*-0&34*),.0140,$((.0*2-1-,+(*./-,1-231/0.4.-,&/01*1.60)0-114,6-30/-/+%04*243.,+*1,+411,0).)/,/*25,'*0400-*02211#/55303036526660&*,+(/'-0#-5.02/3)./.%+-)/%-4564*#&-+142//.350*/*,,1336,0600-(&#/*05+#+.),/,.1203+-)000/.(&(245/-$//-+/2-&()5*303/-+-1$.,.1(*)10+)/+$(/$)-..26,04.3*500/-,0)1./+.13+,&.10-002*,1031.).25+,1.*54(1011*)$()-,0*/*-0,,-)$',,,*+&,-%*-+./.,+12/./)...*1.&001-+*++-0&.0')$))&&*.0.)0)+(%0)&&/+,1.*/1+**()2.10+,)0.-0)$,)+)($*01-1+,/+/(/.-.+$+(,++$&(''*-(,&'(*((((',,'&&#((%'))),+$(*)+,,(&#'#)+("%%$'#$)+,,(*+,,*'*+&+#)'#%++%$#%(-('#+#+&&,,$$"(++$#,*'&$(%0)+/0)0-+$)()('%10%/*0.**,#+.+'+0,0,-1+%/..%*.%,//+*%*-(0(-,,/&/-+%$,,$#&+-.01'-.0/(01,/)*(+.../-,,,#,('&#/**)''%-..',-,"*,-*+--,.%,%+)+$/0&,+00*2+/*%+,,//,-.1.+&(-%*-'&#&+,&,/0/&1)+..%(+,,'$*+*.%$/,/-%,'#21.02*)%,+-*%&*%0))$+**+/.(+11,0-,,-,!&(/(.--&))*02,+'/.+*$(#'-0**(&#$'))'++0*()-%,+'($&(''#'%*/0('$-+$)'(%./%,&)'(&$--,*,+0)1,&'%$&#,$')'+*+0.**)$.0..'#$()//#,-(1**&/*"*+.,#$(*+&-011),.,,&)%)('*&*./$,'%!$)*#$*+,,*%,//0/',,*/&./%/,-/,(.,.-$+,*.$.,00--)%.1,++///.**))'$((,1+)./%*-&(,(*'.122,20%)'%2*4061000(/40,.1-#-0+.3461400-/.-01 @rCer/269/25_1911_CCS ATGGGGAAAAAAGAAAAAGGAAAAGGGAAAATCAATGCCTATGCTACAGCCCAAAGACTCTGATCTGGATATGAGTGGCAGAGCCTGGGCATCTGCATTTTTAAAAAGCTCTGGCAGCGGTTCTGCGTGCAGTTGGGATTATAAGCCAGTAAGCATCTGAGGATGCCCTCTTCCTAGTTGGACCTTGGGTATTGGGCTTTGGGTGTCCTGACCATTGTTCCCTGCTACAGGTCTGGTCAAGGACGCGGCAGGCCTGCGTACTGGTGCCTGACCACGAAATCCTGCACTGCCACAACTGCCGGAAGGAGTTCAGCATCAAGCTCTCCAAGCACCACTGCCGGGCTGCGGACAGGGCTTCTGTGACGAGTGCTCCCACGACCGCCGGGCTGTCCCTTCTCGTGGCTGGGACCATCCCGTCCGAGTCTGCTTCAACTGCAATAAAAAGCCCGGTGACCTTTAACCCCAGCCCCCTCTCCAAGTCCTTCACAATTCCTTAGGTTCTCAGGGTTAGAAACAGTCTCGCGAGGTAGGCCCTCCTCCCGGTCACCTGCTGTGGTGTGTGTCCTCTCCTCTCGCATCCCAGGGCCACTTTCCCTTAATGGAGGTGAGCCTGGCGGCAGGCCCGAAGGCATGAACCCCTCAGGCAGGGGACTGAGCAACTCAACACAAAGGGAATGAACCTGAATCTGTTGCATTTATTTCAGTTAAAAATAATGAATATATATGTGTATATATCTCTCTCATATATACATATGAAAGGCACTCGGGGCATATCGAGGCTGCTGCTGGCTGCGAAGACGTCACACAGTGGCCCCCGCACAGGGTGAGGTGGCAGTGGCAGCACGTCTTCCTCACGAGCCGAGCCAGGTCCACGGCCACCGCGTGGCTGGCCCCTTCCTCTGCTGCTGTTGGAGCCTTGGAAGCCTCTGCTGTCCTTGGCTCTTCCCTCCATGCCTGTCAGCTGCCTGGGGAGTGAGCCTCCCAGGTCCTTCCTGCCTGAAACGGCCTGAAGGGAATGCTCCCTGGGTCTCCTGGGAGTCGAATCCCAATTCTTGGCTTAAGCCTGTTTTAGTCAGAGACCACCCAACTTAGTGTGCAGGTCACCAGAGTGGGTGGAGGTCAGAGGTCGGGTCTTCAGCCCTGAGAAGTGGAAATGCAGGGGCTGTGCTGTCACTGGTCCCCCAGGGGATGGCAAGGAAGGAACTGAGCCTTCCCCAGCAGGGCTTCCTGCCCCGACGCTTCTTTCTCCACTCGGCTTTTCCCAAGAGGCGGCACCCAGCTCCTCAATCGAAGCACCCGCCTCCCCCACCTCAGCCCCCTCGAGCCCACCGTCTGCTTCTGAGTGTCGCACTAGGATTTTCATTGCTTATTTTAAAGTGTCTTAATCCTTTGTTCCCCGACACATAACCCTCTAGCTCTCGGAGGGGCGATCATGAGAAACCTTCCAGGGAAACAGAGCACAGGATGGACTGTTAGTTGTTTTTAAAAGTCTATATATAATTTCAACAGATCATAAAGAAAAAATTTATCTCTTTGGTCCTTGCAAGAGAAGTCAAAGGAACTTTTGTTTCTCCTCAAGAGCCTGGACATCTCTGTCTGTCGTGACTGGAAAGAGCCCGTTGTGCTGAAATCTGTCATCATGGTGGGTTTGATCTTCAGTGGCCAAACATGAAGAATTAAAGTGTAATTCTTGACTGAACTGGTGGATGGGTTGAGCTTTAGGGAAGCGTATGGCAGTCATTCCTGGCGCGCGTATCGGTGTGACATGAGCCCTGGAGTGTGTCGTCCCTCTCAGCCCTGCTCCTTCTGCCTCCTGGGGCCCAGTGACTGGGCCCTGCTCTAGAACTGTGTACCATCCAATTCGCCATCATAAAGGAATCTTCCTG + EA/G?G3JEIHEFFB)CAEA9@GF;HIGEGCEFD@C)7;GDIAHIHHGFG@C:FI@8FF;EGF6IIIIAIIF2:CCFFACF<49GFEEDHAE?DF.IIJI@H??BI9HFF;BD8F@E?I@DII>8J5CJHHE8JJIII?HHHAJB:/4=I@<<@GCIIHGH%@>HEGIHFHH=IB(=;D9?GGD-?:IC*A3B>E8AFFFGB=KEJJGJIJAJ;KGKEJHCFJJJKDFEF5AHIIJK=KCIJI>HJIJGH0EFJF$GAIDKJJJ9KHDHKDIJF8IFGJIEFH@&:7AFF=<0AKIC?KID+E>9DIJF?AHKKHKJKK+>AKKIHHEKK3GE?=KKHGGF@KFHHJHDI:=BB9KKJ>IF(HBAJ4DIKKIJJAE@5D:8?AD5CJJFID8?JJD#CCKFEJKJ0EE6DIE:HFAA?:DIJGE;BFF@GFIJA=BJJIJGHKEKKDKAJKJJ'JJI>BECFJJJ7HJKKFFIKIAFEKJJKKKG:BG9FICGKFKKJKJBAKKK5KJKJJCHJGG9JIKGFKH;G9KKJK?K5HIJJGIKJ5JJI@K&IJBEKJKKI3KJIFJBG:HDKJHCJEGKKJKHCGIDGJJJA=BD>F?FF?GBH4F;GBJFA;CIHIFGHKKFI;JHJJC:E:EAIHB?IHHKDC:E;IIBDJH.EJKKDF:FFHIJKGG@AKC,DGDFF&C@=GKIJIACEIJH>KDKGHIAFCJDK;%E@EI>>HIKJJG0C@2IHHGHJCH3<@>>9FH6DGFHKJBHF7GEEBBF4?KJJ=J?F7F?GHGAGIF7BB&E<J>FIGIKIHADI?C<=A6GDCD8FJBH4HHHFHDIJE?I3E?A@@EID;AC?EI@FKHFJCGCHAHKGGF+FKJ7HAC@87JKI:JHCBCF?CCGC8JHHFIJH8'GEHJFGEJBKJFJBJIEKJ3KJJIJKHJHAKFD0JI6JJGFJJCJKJKIKKIKHKIKHKKJKHGJKIGKGHIHJFKJIKKKIJKJKKE4EEKKJJ@KKJJAKCKK=JHK@@G6GCKIEKJAJKKDJKJHFFI?HJHGKKCKHEGJKKKIIK?KJEKKKJEKKKKIHJDECHKKKGKKFJHKCFKJF9KIJJGGJGKIK:KKKKKGJA=KKJKIKJJKGHJKK?KJFJIKJJKEJIKJJ9KKKKH;GKJKKJD@KK9KKKKJKICKKHHIIKKGDIJEKJJGJHKHKC?KKKGKGHI?EKEKJKJAJIJHHDDKIIH@KGKJKGJKI3KIIEJJEHJKEKIKKKKKIKIJJ@II>KBGAAKDIJFKIKJIKJDJKBKKFCJGEACKI>EFJCKIHK;HBK8BIHJH>KFKFJJHDIKJHF=GG;?DFKJBKIGHJGD>EJF6KJJJKJIKJKKE?DH+IEFE@H0IIJKIJJKF-IBI?@DEDIK>KIBKJH1KKJGEDKEIBJJ>KKKKEHKGKKKE8HDE/FJK8KJJFKKJKIKJBKCJJ>KEKJIEKKKKKKKKJKKKJKKKIHIJ#KKKEGKFHJGAFKJKJKKKKKIKKJIKKKKKKKKKJKEJKKKK=KKKKKKIKKKJK9KAKKKGKKKKKKKKKKKKKKGIKKFJKHJKKKKGKKBKKIKKJKKKKKKKKKKJKKKGEKKKJJJKKKKKKKKKKKKKKDKKKIKKJGFJFEB:C/=;;8+740'4=/)A=$9<;B?6>B<=>2:/-(;64);2>$<-95:3CCA%/1=A2BAB?:;?*@5:>9B?;BAD=A2$1856:=(B@.::55%?:8B@0D>DD>)858(,69<<=F>:(9<#4:68='=8/49/%855<7CB=6@=:5#:;9@B;,:,;=8;?A4C=57C?.B>C>BB9>96@;;737@.43<55=7B;4C-1,3A7:9B79C2878<8@3A>@430AB6+*@><(;/;=?58=3A>2CCCC@>>;29<2555:9:=@;->:7+%290&198-039=>B;A2'>?>/87<=@=6'@=66=82<2;8204<79=<>''&>;=:4./2CCA0'<=>=>=@;2@?C'=*=A>+?A;(=4CC46.6?4/@&=885+3<>47-65;AB;CA3@>(=>:4,833'8;:-<@B=CB?A?<<1:806/6/1868<:<4/+4>;2@@0<+?1?<$;7-03?=?:<9;?@=66:6B:=8/<<>11367:$04;>6388@6<75@'80>23=??=?>B=/*)?<=0;<=7?/34==2<>,@==@=C;50B6.4A=/>7=<%.4>.;1>;6::.A/6?>892@@71=89?B-:.)4%>5>6->6C:;4B@:=<07;@;<27A&7>@>;5+;9A?9>6<76*$,%:AAA68)&71B;C?96BB@7?=6??78-58@7=:7?=&1+;6;96,B;62>%.0>9474:476.3534@B?44>;7>44*4=;4)<4A7<4($2>-@=C:<<9<>95=>@>:23$*/..9;C<973@,8*;,%6&871;.@.5AA;9;68,=)<=@B46)8658:.+533.'0+/2;,67,::?9?(@33:72<;93+/+.-44@@,88-C?<0E.A24=693?;7%6?BA09?3?'>DC@G6>:DAA(==%'#6,(44DC<=DC=@6079-067>@.==6:@B@31>GCAEC?:7>/?AB88A=?@6199$:;3A<;:=*80678B;<84D8%/2:?90=???9'66F;>:<:CB89#0-/B>&>=>=@9>85+0.'@84B5BE(ACB@A672C6:C@AA,=>>?6@A)9E@B'>=@??>:25#'-(55>88$4.19,>34,5:=?>AA819/5@964>=:?@@9:0BC?@4=40;2?60+1>>AB<>C=70;,4:$8-3@1<4,-48415>:57B7A;8(40@@C>:7=.?9;:4<=-;47)7930:/:5=729&3@&;88C68>@8?=&6A>@8CA<:%788@18@95=6<*:=-;;>4>67'8%;'A<38;.1%220<*@A<6=:/@96=5C;1=80A09+<<382<:=;1<:9:==;=862687&*%&7;<)=7;<>?9A.?@A(8:C@(//-@88>=7<8>182A=1:9-845&790$$((8A?=,-6::1<64<+4(,+*<69&/858:@?8?&@<<%5=0?A6<(9>@>.;-.9B:B5<@B0@45?@4259*4--<.%;,*%@?>'9;0=:4&?A7$06(28.),+8<(7*7?53206.+==+52=<-<:A;>-4899A7=2',20&8<=./&<7 @rCer/273/25_2145_CCS ATGGGAGGCTCAGTGCTGCGCTTCGCATCTGAGGCGTCTGCTGCGACAGCTCAGTCAGTCGCGGTCTGTGTGCCGGGGGCTCGTGAGGAGGCAGCTCTTCTAGTAGTGCTCGGCGTCAGACATGGCGGAGGCGATGGATTTGGCAAAGACCCAACGGGCCTACCCATTCCTCGACTCTGTTCGTGAGGGAGGACGGCAGCTCCATGTCCTTCTACGTGCGGCCCAGCCCGGCCAAGCGCCGGCTGTCGACGCTCATCCTGCACGGCGGCGGCACCGTGTGCCGGGTGCAGGAGCCCGGGGCGGTGCTGCTGGCCCAGCCCGGGAGGCGCTGGCCGAGGCCTCGGGTGATTTCATCTCCACGCAGTACATCCTGGACTGCGTGGAGCGCAACGAGAGGCTGGAGCTGGAGGCCTATCGGCTGGGCTCCGCCTCGGCGGCGGACACCGGCTCGAAGCAAAGCCCGGCGCCTGGCCGAGGGCGCTGCAGAGCCGGAGCCGCAGCGGCTCGCGGGGCGGATCGCCTTCACGGATGCGGACGACGTAGCCATCCTGACCTACGTGAAGGAAAATGCCCGCTCGCCCAGTTCCGTCACCGGTAACGCCTTGTGGAAAGCGATGGAGAAGAGCTCGCTCACGCAGCACTCGTGGCAGTCCCTGAAGACCGCTACCTCAAGCACCTGCGGGCCAGGAGCATAAGTACCTGCTGGGGGACGCGCCGGTTAGCCCCTCCTCCAGAAGCTCAAGCGGAAGGCAGAGGAGGACCCGGAGGCCGCGGATAGCGGGGAACCACAGAATAAGAGAACTCCAGATTTGCCTGAAGAAGAGTATGTGAAGGAAGAAATCCAGGAGAATGAAGAAGCAGTCAAAAAGATGCTTGTGGAAGCCACCCGGGAGTTTGAGGAGGTTGTGGTGGATGAGAGCCCTCCTGATTTGAAATACATATAACTATGTGTGATGATGATCCACCCACACCTGAGGAAGACTCAGAAACACAGCCTGATGAGGAGGAGGAAGAAGAAGAAGAAGAAAAAGTTTCTCAACCAGAGGTGGGAGCTGCCATTAAGATCATTCGGCAGTTAATGGAGAAGTTTAACTTGGATCTGTCAACAGTTACACAGGCCTTCCTAAAAAATAGTGGTGAGCTGGAGGCTACTTCCGCCTTCTTAGCATCTGGTCAGAGAGCTGATGGATACCCCATTTGGTCCCGACAAGATGACATAGATTTGCAAAAAGATGATGAGGATACCAGGGAGGCATTGGTCAAAAAATTTGGTGCTCAGAATGTAGCTCGGAGGATTGAATTTCGAAAGAAATAATTGGCAAGATAATGAGAAAAAAAAGTCATGGTAGATGAGGTGGTTAAAAAAAATTGTGACCAATGAACTTTGGAGAGTTCTTGCATTGGAACTGGCACTTACTTTTTGACCATTGCTGCTGTTGCTCTGTGAGTCCTAGATTTTGTAGCCAAGCAGAGTTGTAGAGGGGATAAAAAGAAAGAAATTGGATGTATTTACAATCTCCTTGAACAAGTATCAATGTGTTTATGAAAGGAAGATCTAAACCAGACAGCAGTTGGTCTACATAGTAGTAATCCTTTGTTGGAATGGAACCCTTGCTATATTAGTGACAAAGTGAAAGGAAATTTAGGAGGCATAGGCCATTTCAGGCAGCATAAGTAATCTCCTGTCCTTTGGCAGAAGCTCCTTTAGATTGGGATAGATTCCAAATAAAGAATCTAGAAATATGGGAAGATTTAATTATGAGGCCTTGAACACAGATATCCCAAACCCTTGTCATTTCCCCAGTGAGCTCTGATTTCTAGACTGCTTTGAAAATGCTGTATCATTTTGCTAACTTAGTGTTTGGGGACCCTGCTCTTTGGCTGTTCTTTTTTTGGAGCCCTTCTCAGTCAAGTCTGCAGGATGTCTTTGTTTACCTACCCTCAGTTTTCCTTAAAACACGCACACAACCCTAGAGAGTCTTAAGAATAATGTTACTTGGTTAATGTGTTATTTATTGAGTATAGTTTGTGCTAAGCATTGTGTTCGATTTAAAAATTAGTGGATTGACTCCACTTTGTTGTGTTGTTTTCATTGTTGAAAATAAATATAACTTTGTATT + ??.AC@@AAFEB-*8C>><7<=@FFC@B=>@EAGF9EDFFE>9ED9BFA@CFBE@CBBEACF*C8:9CCEA49A%CCCCC>?B?CD'9A+;=CEEACC?FEC>DA5AAEBF3=>:?FC9DG@B.>?>E@;??ADB=@@3@8*>DCGG>>&@A5DB&A>6A;?)B=?<@4BAEBDFFB?E@FD@<@=.EDC>D5B%5=3?@<FE@@E@AEFAE6E;>A@@C3G*B>D2EFEGFB@=A;6B?CDED@EF@EFAGDC8AAA?73-D2DA@@F?@@A:,CF/CEEAG?@GFE+?(%CE?BEF=@;7C.FEF0A,A9?FGCBFB>AB;AECB99?2?F@F;?DAA=@CDEC9E7C>>AC1C9>+FACFAAEEB9EEAFAA&B<3B)C>?=GEBD=9BCE=BB;BDE@<;DDB?EFBAD9?:6.@DEECECEFA2F>CD6A@GEBD>DD>C8;FCBC@4EBF;E?<@*>AF=AAD=G6@9AGGAB=FBE>CE@2ADC@0B+CBEEA5=@GBAAB>9C4CC=3D<>GAEA>=3CB5;G*B576>BB@CC;;A=FBC@FCA:4@=EEE/?DBB61%?5B=:C?78;?8CBCBFEFA=2@@C5??-A@C@D,DFGCEAE>D8?8?CGED&@;AB;B=%=ABB4<2;=CFAD?DBE5?*=57@EB?CCAH0E:?IA8BD?IF>??IBAG;DA3G9A@D:A>6;5A=7DFF-=C@=?C;<$;:=?EIDDEABE>2F>BDC;4FCA@9,56=2A+DC=CFGEFC@H=92:->84AHEAG8HFDAB@B?EEHFHFI?EC@>>4@,F;>JF8BC=EA6G0+HCDED9FHDCEBJIJDCD4F8(G@=ECDD.C>=FE0H@>E:9HJIGF?=AAGFGDFBDEG/GGII2EHDI3?BA<7@C9?:BFCD=3B?>2AB<>A:@F>(G@@=978C@@E@DG@D=FFDJC?@8BH6FGAD=FFG1IJJIJJIFEEGD/FE?EI=C@9?5>AHF?GBD<@B@G@A;2==D7=?DC1<<;A48@7=<9*;;@?;(8632.&==94:?6:4A?:A1>'==<=-<54>;EEEF@6?3-CB;A*(=*:A;>832=?=<7=47?48;4FB5CA>&C@*B@69C-G:EB8BGFF;AA5==7;=B@=7C;8A=ADB@'>=BC)EF@EBFD?D=@?DCBFDBD3B91?ADD5E6?*8>CBDCB;CDFFD=5AA@?>@>EAECC6CDBG>CBE@>>D=C:GE;GCECAGC96:-BD/BA1FA8=9:@8586(459=A85AE;AAC=81;@=9CA>ADF>@EB@:DDCEC??D61#@7,7@?AA;:AA>?@>3F3A?4EBF:3:>7AD>B=;1>D5+:<;::B=GA<+:1=?;:BEF>F=EBCDA>7CBGC>FDD2;874CF@ADD=$?;8?FF5FE?7>6>1EDC>B>2=E:7;;B2B><9?78+:8EA=:47:4B@C@DBEBFF2EAA6@:9=?@;@C?F;CFFFF7A<;<04::%97AD:=CA#<91EF0D>C@?3CACAG?@3?=EB0A>:D@CD@BC@2@B1C;?<(942:?:AB;GGFA@6> @rCer/275/1673_57_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTT + KKKKFKK9JAKKJKKKHKJKKKKJKKKEKKKK=KKKKKKKKKKKKKEFKKKKIKKKKKKKHKIJKK4GKKKKKFKBKKKJKKKKKKKKKJJKJJIKKKKKJKKKJJKKKKKKKJKKKKFKKKKKKKKKKKKKKIKKEKKKKKKKJKJKKKKHKBJKKKKKKKKKKJKKKKKKKKKGKKDKJKKKKIKKBKJKKKKKIKEEKKKHKKK*KKKJKKKKJIJFJKKJKIKGJKKKJKKKKK?K=JKKIKBKKKCKDKKEKKKK?KKKKKKKKKFHKKKKKEKBCDFJKKKKKJKKKBKKKKKIAJKKKKJKKKKKGKKKKKKKGKKKKKK?KCHKK+KKKKKJKKKKK>=EKIJKKKKEJKKF>EJKIKKJKKKKKKKKKKKKKEKKKKIKKKKKKJKKJIKKK>KKKKKKKKKDKKKKKKKKK9KKKK*KKKKKKIKKKJKKKKJKKI9HJBKKKKKKHKKKHKKKKAKKKJKKKKKKKKKKKKKKKKKKIKKKKKKKKIKKKKJKKKKKKBKKKKKKKKKKKKKKKKAKKKJHKKKKKKKKKIKKKKKKKKKKHGIKKKKKKJKKGJKHKKJKKKKKKKJKJKKKK3KKKKKIKKKKIKKKKKDKJKIKKKIKKKKAKJKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKJKKKKKGKKKKIKKAKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKJKKKKKKJKKKKHKHKKKKKKKKKKKKKKKJKKKKKKKGKKKKKKJKKJKKGKKKK1KKK:KKKKKKJKKKKIKKKKCKKKKKKJKKKKKKKKKKKKKKKKKKIKKKKJIKKKK9KKKJKKKKKKKKEGGKKKKIJKHKKKKKKKKKKKHKKKKKIKKKIKKKKKKKKKKIKKKKKKKKKKGK;B>62::;(@?C8=<=:@=A@BB5=;6=3B;<6=3>=@B54==>B7>A8?;A0?=;>B692567(95C=@?;;9<8:79>807B9?<9=A9?=A>@@;58367;=;4=93;==?==6<>>>56>?;>70=8=88=6;;:9;>:549;::&;8><;96?;<*.<==5?=:2;:==;==>;><<:878>>=3==6<=,;3:48>=:6468;68-8>=?=:<9:<07#2,6<:2;>;78>=;=;>799805;.;;;<>9::=5;/969=8989.76/6:;=6<:;3<=;;74;=8:98845>6511382=;;:>>?<93<99?=675:;767);=7>;=5>:;3/:5/78;0740889;=0067=<8.7:724626583567870/86%&53-;:489<66<;:-<::.;<6;759=51::>6/2/447.;=<:7:<55::4=959;4>9:;/65>:?=><93:4+1:9178;:7;>>=<625>67<7:>=:0779732837,66$594;8=80;<;6:58/6>9795788<26=6=507.585:?==?=8:8=2>/?9?B?:=?<=7=@438@=;?=>.;?>=9;@=:>5:BAB;==;:<:?A>??@@;283.6=;8:562;=;;;8B+@96C====;?@=A;C>?::88275:9<&;<;?C>8696;9'48<@<:<;>/=@:-BA@@;=C<@>A;@:;=<+<>>1?>99=9>A??;A;4<=7B>?;655>;?9A?>A?>;C:B@@AAA;8?A<:<>9>@<@?B;=A?8C::@>;?524=;@';>62;<*@89:>6;5+6<97<6A>8>=>,?BA?C=;@<6A>:<>6:;9:5<BA79<=@<4B?@=@<9C6>AAC:7<@6?:.;6BA@?C8?3>>A=A9?A>?=B?@A;9A8;6?>BAA>?,8<<=:9<;<>6;>$=?3@==>@AA@=@=<@676-@=?AAB?6&4<<:=@C@>>>77==>=&=@A@>B49;>;443=:A4=;2?CAC=B@?:A?06+193646>==;-?@6>8@>A@===;62:9:;8B>AA9;3>;4?B>?-9>;;<9B>A@=B<::;8==AC:>>?;?A47:7;8:3??@9=A?C>;>:96498>648BB:51;9&;=C?><=>701?#<=77;B@<=:?;9?;:=)=?-:7>997>8@3*A=:=:=>AB?A@7>=-:9=A?4=@=949+831>>@49>,?>8=??-<79?-<9873=<30<:>>?:6?=?B>C@A9@?<@<@CC<@:=4@;67;0;8=:<<&>:6@A:+<845<<;6,:23:91551:=:1<9<>@>-0@;65=@@=<>?=B1<@<:/72A;97<:=:+:<8==9>7@B54663<9:A>2>;@??=@63AA::@1A:=>>.;C@;=;B@9A?@:@=?>A:CAB=??-/?BBBBA*A?@:< @rCer/279/813_52_CCS CATGTACATTACATGCTGCTGCGGCTGTTTGTACGCCGTGTGCGGTTGATGATGTTTCCAACAAACCATGGTTCAATGGCAGAATGCGAACTATGAACGCTCTGTGACAACAGCGCTAGCCAGTCCGCTGAGTTTGGTTGGTACTTTGTGGCCCCACTTGGCATTCGTAATGTGTGTTTTGACGCCTATGCAGTATCAACTTACCGAGCCTTTGCGGCCACTTTGTGACTGGGTGAGACACTTGGCCAGAGTATCATGAGAGCTGCTTGCGTGCTGAGTCGTGTATGAGATGCGATACAAAGCTCATCTCTGAGCAGAGTGTAGTATTCATAATGGAATGGTTAGAGGTGGTAGAGCTGTAGATCGTGTATGAATCGCGTTGCTTGTACTGGATGTGTGTGCGGTGTAGGAGCATACTGCCTCCGTGCAGTAAATGGTTAGAAGGCGAGTTTTCAGGAGGCCTAAACCGGCCTGTCCCTTTTGAGAAGGATTTCTGAGTGCCTTCGTGGGCATTCTGGTTATTGAAGCGATGAGTGATTGTGAGGAAAGAGAGGAAAAATAATAATGGTCATCTGCATTCCTTTGGCAACTGTACAGTGCAGCAGTCATGTCCCAGGATTTCAGTTCAGCTTAGTGAAGAATTAACTTTATGGTAGATTGTTTATCACATTTTGTGATTTGTCGTTTTGTCCATGAAAATAATTTAATACCAATATAATATTTTCCATGATGTCTCTAAAAGTAAATATGATGATATAATC + .,&+,+"&,'-)(&++)-*,+.&%-#+%,)&,-..%,-),&.**('(),,+%*%&###,#(+)',%%#(***&,-++*(---$+(.*&((%#$##!$"&&$(+..,---+,$+--,,.*+..-+---(%/(.-&(.$,'%("'(*"$-*)%&+'*--&$.(**/*-//+(#-$#+*'$#+(+&.(,&,%('''$.-$-./-*...''%')#&%&&#**',-.%$(),,,'.+%'$-%'(')&"$%'..'+(,&-..,..%##.,+,,'*)+,(-'(",("&#%%+---'(#/*/+--.*)".-+#,-#'&+,(..-,,(,*)($#$""%&""#$#"#%"#$&$#-%+&$#$(&'*"&))*)+$%*((&##'!*+&++*'##+*'$%#,(&$&",.--*+),.,+)..,/(*,+*.(*,*)*.),-/,./(+-"%-,),&.-+-,(.-*(#((*/.+%)$'%-%.().)+)+.'#,)*).&#$(.,.",).-$-/)//%.+*(,')*+&)$*-+%.'($(%*'%%.,/.).&-/*++-/+--*/&***,--*//','#+.--%-/.'/,,$//.*.-.,$..-((-(-*$*.-+*,-(+,-#)*(,++%,,)"+).,'.%($--,)).$./,(.-+.$-,(--&/)-.**.+-+".-.,#()$#%%-,&#*&#(++*.,)(,--/.',*.-+#.#.,'().-*%"$++'+.,,/-/*.-*+,&)'(,,),&+,*(*(&*%'&%+,(&)&#"'#$&"&"$'"+ @rCer/281/25_2236_CCS ATGGGGAAGCGCAACCGTCGGTGGGTCGGGGATCGGTCGCCTGAGAGGTATTACCTCTTCTGGGCTCAAGATGGACAACAAGAAGCGCCTGGCCTACGCCATCATCCAGTTCCTGCACGATCAGCTCCGGCACGGGGGCCTCTCGTCCGACGCGCAGGAGAGCTTGGAAGTCGCCATCCAGTGCCTGGAGACTGCATTTGGAGTGACGGTGGAAGACAGCGATCTCGCTCTCCCTCAGACTCTGCCAGAGATATTTGAAGCGGCTGCCACGGGCAAGGAGGTGCCGCAGGACCTGAGGAGCCCTGCGCGAACCCCACCTTCTGAGGAGGACTCAGCAGAGGCAGAGCGCCTTAAAACCGAAGGAAACGAGCAGATGAAAGTGGAAAACTTCGAAGCTGCCGTGCATTTCTACGGAAAAGCCATCGAGCTCAACCCAGCCAACGCCGTCTATTTCTGCAACAGAGCTGCTGCCTACAGCAAACTCGGCAACTATGCAGGCGCGGTGCAGGACTGTGAGCGGGCCATCTGCATCGACCCCGCCTACAGCAAGGCCTACGGCAGGATGGGCCTGGCGCTCTCCAGCCTGAACAAGCACGTGGAGGCCGTGGCCTACTACAAGAAGGCCCTGGAGCTGGACCCTGACAACGAGACGTACAAGTCCAACCTCAAGATAGCGGAGCTGAAGCTGCGGGAGGCCCCCAGCCCCACGGGAGGCGTGGGCAGCTTCGACATCGCCGGCCTGCTGAACAACCCCGGCTTCATGAGCATGGCTTCAAACCTAATGAACAACCCCCAGATTCAGCAGCTCATGTCCGGCATGATTTCGGGTGGCAACAACCCCTTGGGCACTCCCGGCACCAGCCCCTCGCAGAACGACCTGGCCAGCCTCATCCAGGCGGGTCAGCAGTTTGCGCAGCAGATGCAGCAGCAGAACCCAGAATTGATAGAGCAGCTCAGGAGCCAGATCCGGAGTCGGACGCCCAGCGCCAGCAACGATGACCAGCAGGAGTGACGCCGCCCGCTCCCGGTGTGATCGCGTCCTTCCCTGGCTGACTGGAAGCCTCTGGTTGTCTGCCGTTTCCTCCTGTTGGACTGCCCGAGAGAGGGGAAGAGAGGGACCTCGGACCTGCATGTCAAGATGGATTTTCCCCTTTTATCTCTGTCCTCCTCCACTCCCTTTTTGTAACTCCCTGACAGCCCCCGAACCCTTCTTGAAATGAGAGCCAGCAAGCTGAGCACAGACCAGCAGTGACCTACCTTCCAGCCCCAGAAAGCTCAGTCACCTGAGTGTTTTCTAGAATCCTGGGGGACTCCTGGGCCGCTCTCGGAGAAGCGACCGGTTTCACGTTCAGCCGTGTGGCTTCCAAAGCCTTTTACAGCCCCGCCCCCCATCCCGTGGTGTGTCTGCAGGAACTCTCCCGTCCGTGAGAAGCCGCTTTCCCAGTCGACCTCCCGGCCACCCTGGCCCCGTGCCTGCTCGGAGGAGCTCACTGCCAGCCGCGGCCTGCGCGCCATGGGTCATGTGTGTTTGCATGAGGAACTCTTTAGTGGCAGACACCTCAGAGACGGCTGTGGTCACCCCCGCCTCCGCAGCCCAGGAGCCGTCCTGGGTGCATAGGACCAGTTTCTGTGACTCTTCTCCAGTTGGGCATGTTGACAGACATGCGTTTCCCCTCCTCCCACCCTCATTTTCTGGTCCTTGCGACAGAACCAGGGGCGACATCATGACCTTCTGTCCCGGCCGCCTTAGCCCTGGGCACAGGGAAGGCAGCTGGGCCGTTTCTGTCTGTCCTGTCCTGCTGTCCTTCTGTCCTGGGTGTTTCACGGACCCAGGGCCCCCCCAGGAAGCTTATCCCCCTATTCTGGGTGGAGGCCACGGGGTACCTCAGGTGCCACCCACCTTGGCCCTAAAACAGCCACCAGGAAAGCAGCCAGATAGCCGGACAGCAGGGGGCCTGTCTCGGTTCCTGAGGCCTGGGGTGGCAGGCGAGCCCATGCGCCGTGGTCCCGGCTGCAGGGTTGTCAGTCGGAGTGTCCTGGGGCTCCCTGGCTCTTGGCCATCTGTGAGGTAGGCGCAGTACCGTGTGTCGTAGGTAACAGTAGGAACGGGGGCCGCCGCGGCCCTGCAGCCCCTCACGGCGGTGAGGCGTGTGCCGAGCCCACCCGGGGTGCAGGGCGTGACGTGTGAGGAATAAATAGGCATTGTGACCT + IJ+KKGCKKJKEAHEJEFIJKH3JKHJ5JJF=HIKKJ;EHFJJCID=F>HHJCCGKHIJ@HIJIKBKD:H+JJI@7CFF;FJI%IKGFJKKKIIHJDIB@4J>KHGJKJJJKJE5HCHGI/IGF?DB:KKIGFKJJHKKKBGI(B>HKJ@;JBGDH@CI?I?EAKIKJJK@KJGKJIKKKJFBGKCJIEIK-KKHEJGJK@KKJEIJKKDKGJGIKIKKFIKJIKIJJFIIHKKBKHHKJKKEHJIE,CIKIHKKJJJJDHKHKGEJGIBKIBHHII(JKFKCEKJKKKKKFGJJGIKJGIJ>KHGJJJJ9AB8IIKJJ5J?KHBKKKJ5=H@KKK?KKK@HAKHG:KJEJJGKJKAKJKHKHKKKGKDKKJ/C9KIKJIGJJKKEGGHKJJKHF@KIHJKK4IBH?K:JKJKFIBKKKKI-KKKDIHHK;KGIJHJFKKI6JKKJJ:KCKEKHJGJK3HJCK+FHK5JDKJIKD?BJJ>KJFK.KKKKJJ77GIJJKKJAD?KKJKKKJKJ8KKJJG9JKJJ:D6@FJKJHJIBJJK7KHIK9KHHJJDJKDHJKIKJKKJKIIAKJJI:EKJKGHJKGKJIG-KJEJJJHJIIG@IJJGJJJ?KGFKJGJGJHEGJKIKGIKKKH?=HK8KKBEIFKKJKHIAJHK5KJI7KDJKKKJCG8IJ>JD@?JK=KHGEJKKKJ5KK@GIIKKK=KKKKIIKKKKIJFIGJ>JKKFKJBHEIIJFJKIHHKKBKIKKJKHJJ;C<=EJKK-KKD8JIK6EKKGFJKKKKIEJD@IJJKFKKKKKJAKJKKIJDKIKJHGFHGIKKH?KHKJKFC%KHKKJ'KKIJKKJJJIKJKKKKJBJKHJ4IKGIKKJJKKKHGK7KKJJBKKBD>IIADJJ>FIIEFIDECGJHJAFA?CHHJ$ABDH=KECGJKACKFEKHIE3IFG7JEKIFIKK0H5)JJJJHHC?GAKKKJKF@$DDFE<@?IE5+II?EKIDJ*JHJ6KJKJDAKBJHFKJADKH?J@DIKHKFKHJKJ;KJEJD?JKDGF9EHAIIIJJJBJKKJHIJ>K=KJKIJIA1IKHKHJJHHAKHGKHHFKBGBIKAKH$KIJHHGKKBHHJKKDJJIEFFKKKKJCKF'IEDK>?JKI9KF7IKKKJKIKIKDCCCAIKCJKKKJJJJKICKI>J6KKK>JIADEHGKKBKKJIK;ECEHGH>KHJIGKKKJHH9KGJKJ?KIJIJ3HF)GFCJJKKDKJJFH:IKJJIDC.GFHJKJJCJIEKKKDFHJDGJJD.KKIH>KJG=JF(KGA@FJCKHKKGHIJKIKKGKK8JKE6IKKKKKKKKEGKEKHKKKJKKKHKKJ1HKIJKKIKJKKHKKKKKKGJKKKKJKJKGKKKKKKKKJFD42@KKKJKKKKKKKKCKKKKCKJKKKJIJ?KKIK@HKKHKJCKKJHJJJKHKDAIJ;DKJKKJ;KI5KJ;K8GKKKKJIKKJ6KGKKKKKCIKEBKKKKK>JIHKGJAEKJKIJJJFJK@KBKEK8K3IKKKCKKKKCKBKKK@KKFKBKGJIJIJJKJJKHGFKBKGKKKK,KKJKIKAKBK>JHKA@KKKIJIBIB?IC:JEKKIJKKK?KJKKGKKKJHJJJJKFKI9KKIIKKEKFIIJJKKKDKKJJ7CFF&JKK=JIKJEAIHJ4?J=JHEKFGKKJIFKIDHEJHKKGIK1;JIIGJ5KJADDGKDGGB=?FJHJ=JHCJGIFJHIHFEHKHKJKIFACIEHCJKJIIJ0JKIJAD:IFGEG;DKIJFECGJIEG)FHKIJKBGJHJH8JJEJEBIHG<@JJKKGK>E>F@EFJ7JIII5FJFKGJI*EHHHFE2IJKKFFHEIHJ7JFKKEGHJE@GKBIKIIJKEJKBIFG/KAKJI:FKKJJJDDHD8JIECGKHDIKJJ7AJHC?E?EFJEGHIKK?JGIAH=F>HKIIK?GICIJHFHEAAKKKKJ:KJGGKKKAKKK>BE:HIIIKKEJHGFGH>JDBAIHKIEIHKFFKBIIJEJJJJE;IDGB4;FG;D9GE3EHHJ@HKKGCHJ8FF1HIKDEJE=HI7JGIIKKKBIKGII4IKJJII@8J9HJACHII7HE;GJKI=JIGK=DIJFDEHH*JKKHADKFKJJ>JIG?JJJJEAFAB@8>HIKJFKIIKH:FJJKFDICKKBE9IJI=HH:DGJJ2EJIFIK==/F1-FG0JKE+I.ECA@5FHJGKJA;KKIHJAIFKH@JC*B@&GAKGKJ.G31>HCAH=KIJJEJJB6&KBBKKKG>GJKFKGJIJJI+I=H9@K?G0D:BE1H:.J5'AB8-FJ,FIE4IH>EJH1K@;.KJDK4KIK?HJDG,JEDKJ:?A:D6JHHKKIJ6GEJJG*JKJD21&J4IIEK:JJIJ?FJ1D/>GGK@KCHKF=AIKKKJKJD>KK@FKKKHJJE2IFJKB7KFGJ@KKK@K6KFCDKEJEKJIFH@DJHKK:JK+KIB2JKK>KHHIKKKKJJG4EGI5;KA'F?JH:>,KEFKKAKKKI7@GIK:KKJJKJG$@K+JK8HFK,KKK8KGKGIGK>BCKJ-ECIJJ9EH;=JKKI7?IJGKIKKIHKGIAK3KJ2?EFKIKKEKBJK7K.KC@KJKAC-IKKJKCD?D7J>6J2;KFK.3KKI-IKIHIIKJFKJK=KCC?@KIFKKHG?K5JKJJCGIHKKIFHKKKKKG(KKKHHHEJKK7K&JJ>2J.;<<%K0>KJKKKKJDIKKGK&G$'KI>@=<5AEKHI:KAGGJIIKI6JBK;1HKDKAG'KKHKKIHDEFK:K:KKK3KGJKCKK@KKKKK.J&$KJIKBKICJKJCKI>CK?K7,KJHEKIAKCIJKEFEKJKDKKJFKICFKK>FKK6K>K+K=K:K8KH??KK;KDGI;=?GKCIJI+GGJIJKKEFJ%KKKKJI@'J/4F>,KK6KHIJHIJJFKGJKJIKKHK%KKKEKKK=KKJJCKKKKHE>KJ6B.KBKK>KKJ.KKI@KKKKJ*KKHKAK;EJDKKIKIJKKK@KJJ;J@KKAKDFII>KKKIKI50K.KKJKKJ+KKGKKKK>KK3KKIGKK$KJKKGKKKKK:EIH>KKKJGKIFKHKKKKKKKGKIKIKGKKKKGKJK?KKKIJKKKJFKKKKJKJKKKGKKKH/KJKKJKKKKIKKKKKJGJ1JJGJ9BKJKHKIKKKKKBAKIHKKK%KKKKKKKJKKJJKKJKJKKKKIJKKKKIKJCH4KCKJKIAKKKKKKJKJKKKKKKKKKII>KJKKFKJKKKKK/KKKKKKKKJKKJKCKKJKIKKIKKKKKKKKKKKKJKKKKKKKKKKJKJKKJKKKKKJKKKKKKKKKKKKKIKHKKKKKKKJKKKJKKKJHI7KKFKKKKKKKF6KKKJKKIKKIJKJKKKKJKK7KKKKIKKHKKKKKJK&KKKKJKKKKKGKKKKKKKKKKGKKKKKKKKKKKJKKKKKKKKDKKJ?KKKKKKKKCKI@KJKKKKKKJK7KKKKKKIKKKKKKKKJEKKKIKKKKKKKKKKKBGKIKKKKKKKKKHKKKKKHKKKKKKJKJ5FKKKKBKJKKKJKKHKKKIHKKK(KKK1KKKKKKFKKKK&KKJJKHKJKJKKKKKKEKKKKKFKKKDKKKJKFKKKIKKKKIKKKKKKKKKKK7KKIKKKBKKKKKKKKKKKKK>KKKKKKKKKAKKHKBKKAKDJKKKKKKIKKKKKKKDK @rCer/290/382_58_CCS TCTCATACCAGGAGCTCGGCCCCTTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGAGATGGCAGTGTTCTTCTCTGGGCCTGATCCACTTTACACCAGCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCTTTCTATCCCAATCACAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTTGGCT + (($%&*'%*(/)%+.,+1+/.*%*.21)/),0,,1*01,0-1,00,--,/1))))%($(10/0+/0,/+-(1--+,-,$'/100-'*//,2-.,$)&'%,0&.,0(,/,*-,.'#(&*-'0/-%./(/(1/.1..0'*))'))-0.2,)/11...#-+)10-4/0450/5.*(*)4/-+/+$0(5,26..985)002'16))04/0-$0(/+'&)(002&,(0520/(0**-.)'#+-26.*+10../-)/4562.1.).0$&10-0(7360.)02287.109426,57577.:68435091,750*267.8511(70844)4. @rCer/292/2288_60_CCS AATGGGGACCCGGAAATGTTATTGAAGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAAGCATTTCCCGTGGTTTCCAGTATGCAGCCGATTGATACTGTGTCTCTACCCAGTACAGGGTGGCAGGCTCTGTCTGCACTTCCCAGTGGCCAGATGAGCCAGTCCCGAGTATGTGGATAGAACAGTTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACGCCACACATAAGCTTTCTACTACCAAAGGTTCCCACAGCCTGTTGAGGAGAAGGTTGGTGCTTTCACAAGATAATAGAAGCCATGGATTCACAGGACCTTTGAAATACAGTAAATGGAAGATAAGATTGCGGCCCTGCGCATGTATACTAGCCTGTGTGGAGAAAATGACTTCGGGGAATTCTTCTAGGTGTCAGATGCCTGATACATTCATTCATGGTTTCTTATAACCCTACTCCACGTCTGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGAAGAGTACATGTGTCGTATGCATAGTTCATTTTATTGTGGGAGGATGTTCAGCAGCCGCGGCGAGTCATGGGGTTAATCCTATATCCTGAAAAAGACATGATCCTCATGACAAATCATTTCTATGCAGCGATCTTGGGATATGATGAGGGGATCCTTTCAGATGATCATGGGCTGGCCGCTGCCCTCTGGAGAACCTTCTTCAACGGGAAATGTGAAGACCCTCGACATCTTGAATTGCTGTAGAGTATGTGAGGAAACAGATGCAGTACCTGGATTCCATGAACGGGGAGGATCTGCTTCTGACAGGGGAGGTGAGCTGGCGCCCTCTAGTGGAGAAGAATCCTCAGAGCATCCTGAAGCCCCATTCTCCCACTTACAACGACGGGGACTTGATGGGCTGGGCCCTCTGCACGGCTGGCCAGCTGGCTTCGAGGAAACCTCCAGGAGAGACGTGCCTGTTGGTCCAGGACCCCGCAGAAAGTGGCCTGAACTGACCTCTGAACAGCAATCTGTCAATACCTGCCCCATTTGTGTTGGTTCTCTTAGTGTGCCCAGGAGTATGATCTGCTGGATCAGGGATGGGAGCACCCCTAGCTCTCCCACGTGTCCTCTCCCTCGGAAGCCCGAGTGAGAGTCCCCCAGCAACACTCCCCAACCCTCCAAGCACTACCTGTGACTGACAGCTTTTCCAAAGGCAAGGAAGGGATGGGCATAGGTTCAAAAGGGAAACCCCCCAGGGGTTGCTGTGGCCTAGAGGCGGACTGTAATGCTGCGGAATCTGGATGGCAACCATGTGTTGTCCCTCGGCTTCCAGCCATGGGGTTGAGTTGGCCATTAAAAGAAACAGACTTCTCTCTACCATGGCCCTTCTTTATTCCAGGACTTAGAAACTCGCCTGAGTTGGTGGCTGCGGTAGTGAGGGCACCACCCAGCTCAGTTAGTGACGGAGAAAGGGAAGGGCTGGATGGTCTCTGCTGCTGCTTCTTGCCTCTAGTTCATGGAGATGTGTCTCTGTTCAGGCCAAGGCACAGCCAGCCAGGCCCCTCGTCTGGGACCCAGGAGGCCTCTGATGACCAAGGGCTTTCACATCCTACGTCATTTGGATGAGGCCTTGAGACAAAGTCACCTTTGTCACAGTGAACTGATGAGGAACATGCTGTCTCCTCTCTTTGGCTCCCCTTTCATGAGATATTAGGGAGAAGAGAACATTCCTCCTGCTTAGTTGTAGCAGACCCAGACCGTGCCCAGCTTTGGGCCCCTTCCCAACTTCTGAAGCACGTGCTGCAGAGCCACCTTGGTCTGAGCAACTGGGACCAGCCCCTCCTCCCATGCAGGTCATCTCTTGGGGATTTTCTTTAAAGTGAAGAAAGGGAGTGGGGAACCATATTGCCCTTCCTCCCCCATCAAACTTCCTTCATTTAACTTGCTATAAAATGAGTCATATAAAGAAACTCTATATGGGTGAGGTATATCCCACTTCTGTGAAAACATTACAAAATCAAACCGCCTCTCTCAGTTTATTTAAGATGCTTTTGTTGCGAGCGGAGCTCTAGAGTGAAGCTCCTGTGTGTGTGAGATAATAACACCTTGTAACTCATTACAGCTGGGCACTATTTACATAAACCAGAGCTGAGCCAGGCAGGAATTTGCTGATTTAATTTATTTTTAATGGAGTGAGTATACCATGCACCAAAATAAACTTTACTGTGTGTAC + ,),---((++'-+.)+'#+,--)+,',-*--,,)---+'(,.,)+)---(.,-))(&(%,,,-**)%#&+)-.*),#&(-)--(()+($(----(-,--.*(--*#+---&%$('(-*)$**'')%%$)(&,,-&*(,)(,*)#++,-',-'+(,,'%#()')&,,-((*,-*)),,&%$'*,),$$'+))*$'*,),-((',*$&-,),-++,,-.,+,.----,)---((-((('+),.)&,--)*(+,&(+&,+&+('$-*&&),,''(**&--.,*,-(-)-,.,&,--,('(),$(&#%$,,+,&,.-*'-)&+')***-+&+(--)+++&,)(,-,)-()()())"#'')&,(,-&'#$$--)----*'&%%%&%"$&,--*+,)*(*--#)*-((&(%#&$.+(')&#&'$$&#(()*'#'&,&())+))**)'&((''()&,*'$*)()''(&'*,),-)*(,*,(##'''*))$((,*$,)()*,((+(''('%$('-)()'+$#"#'('(,%#*''&%&$&%"%#'&('+,+'&)(&'#$&$'$)*')-,,)'*%&,+("'((+#'%%)%((--,)'(,,,)%)('&(+(&))$'('&#*'--+(,%,)+-))(((%(%#$%$%%((%%%#())'('$$'$(&#&((&()'%$$"#)()('%%$$&#$#&%''$"&#%%(%$((((&%(%&)&%"'%'&%%&)(()()(&'(%$$%%%(%('''#$&&%'$'()())&$$#'$$%$&$%'(()((')((&%&$#'(%((%'$%$'%&((%)%%(()())))())(%()'(%$$()%()'&')%()((%('%()((())'%'&$%($$$#'%()(((%(&%%$%#$"%%())'(&&'$()'%'''$&#)((('%')))%))('$)()'%$$"$'()())%')()'#')&(()()'$#$$&%())))()(($#'%()%(($%&$%%%%%#%#$%($($((%#$%'&'%%('%(((%($%%'%(()(#$(()%(((('%&%($$"$%())'&#&$&"##$$$#'''$%%%'##$&""'%%%%%&'))))'%''%()(%'%()((&()%$##'((%%()$'($#$&(($%''((%'))(())))')%&"'))')'&$)(&'($()('))(('%&(('%'%##""##&'(($&"#%"&($$#$%&''#('%(&&%'%(%%#%%)()#'#&)$$""'#(((%(($((('%(%%$)()('''&"()(('%)))))$#())#"!('#(()('#$$#$##%)('%')))'%(%$())'($())(((()(&&%)((%(((($('((#'))(()&((%$(&(())))))(&()()(('%)'&%%%%$&$&$'&$'$%''%'(%'%($%$(&%%%()))((%&$#(%%%'$%&((#'%('(%'%(()())()((&())))))&((('%())'$(&()'%('$')(($%(((%#'(%'%))((&%&%%&$"%()('%''(%(%$#$$&&#($$%&%$$'($$$&$"(%()()#$((%%%$')%%'$%%&)&&%&$()))())))()%$$##%%('%())'%&'#()&()()('%'%()(#$#%$))(()%($#%%()&%()'%()))(&($!&()%&"%$(('%'))(&*$&-*(('+)'(,-,)+,&(&'#%#('(-',*--,*-*&(-,-((&+($&$$')-+'&((+-()---+'-,-.-,,&)(**'*',))&)%&+$%$,-),,+&)++(,+$'$"#&&*-#(*(,-),)*'($-.*,-,&%&&+')+).--,+,&,,+(,--(')+,'(--),,&,+,'+*'**+)'#$)#++&--**()(#(((&&%##'(,,,&$'%"&)'-&)('#()*+',)(&,,%((*)*-..*-.)(-++--(-(*()*',$+-.+-)-''%&#&#,&(+)&(,),()%,)--).,-.-),,(*++&#'(+)(('()-*),-,-*)),-++'')-)+-++)(,,$(-.*,-.+),*(((,*$(,+'*)---(-*,+(-),,&#+,(+-,(+-)-.,-*,(),,')*,&*+&)(**(--),-,--+)+)---&&"")-$)*&($&&&%&$%#(---.,**+'-++&+%+-+*&'+(------(---,))-),*-,..-.-,*),*--+&+&*----.,+(,-&')-,$$)$,*(,+,++,,$*#*-*)('%#(+&((-'+-)'+-,-)&%'*,$&,*)+&*,,),,*,- @rCer/293/1854_51_CCS AGCGGGAGTGTTTGTGCCCCGGAGCTTTGATGAGCTTGGAGAGATCATCCAGTCTGTGTACGAAGATCTTGTGGCCAATGGAGTCATTGTACCTGCCCAGGAGGTGCGCCCCCACCGTGCCATGGACTACTCTGGGCCAGGGAGCTTGGTTTTGATCCGCAAACCTGCCTCATTCATGACCAGATCTGTGATGAGCGAGGACAGGAGCTCATCTACGCGGGCATGCCCATCACGGAGGTCTTCAAGGAAGAGATGGGCATTGGCGGGGTCCTCGCCTCCTCTGGTTCCAGAAAAGGTTGCCTAAGTACTCTTGCCAGTTCATTGAGATGTTTCTGATGGTAACAGCTGATCACGGGCCAGCCGTCTCAGGAGCCCACAACACCATCATTTGTGCGCGAGCTGGGAAAGACCTGGTCTCCAGCCTCACCTCGGGGCTGCTCACCATCGGGGATCGGTTTGGGGTGCCTTGGATGCAGCAGCCAGATGTTCAGTAAAGCCTTTGACAGTGGCATTATCCCCATGGAGTTGTGAACAAGATGAAGAAGGGAAGGGAAACTGATCATGGCATTGGTCACCGAGTGAAGTCGATAAACAACCCAGACATGCGAGTGCAGATCCTCAAAGATTACGTCAGGCAGCACTTTCTGCACTCCTCTGCTCGATTATGCACTGAAGTAGAGAAGATTACCACCTCAAAGAAGCAAATCTTATCCTGAACGTAAGATGGTCCATCGGAGTCGCATTCGTGGACATGCTTAGAAACTGTGGTCCTTTACTCGGGAGGAAGCTGATGAATACATTGACATTGGAGCCCTCAATGGCATCTTTGTGCTGGGAGGAGTATGGGCTTCATTGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGCGTATCGTCATCCATGGGACGATATTTCATATGTTCTTCCCGGAACACATGAGCATGTAACAAAGCCAGGAACCCTACTGCAGTAAACCGAACAAGAACTCCCCCCGCAAGGAAAAAGTGTACAGACAGCTGCAGTGGAGCCTGCTTATTTAGCAGGGCCTGGAATGTAAATAGCCACTGGGGTATAGGCACCGAAGACCAACATCCACAAGCTAACACCCCTTCAGCCCACACAAAGAAGCTCATATTTTTTTTTATAGCATAGAAATAAAAACCAAGCCATACTGTGACTTTACTCTGCACCTGCTATATTTATTTCATGGAAGCATCTAAGTACTGTCAGGATGGGTTCTTCCTCATTGTAGGGCGTTAGGATGTTGCTTTCTTTTCCATTAGTTAAACATTTTTTCTCCCTGAGGAAGGGAATGAAACATTTAAGGCCTCAAGATACTATACATTTAAAGCACCCCAATGTCTTTTTTTTACTTCCCTTTCTTCTTCCTTATATAACATGAAGAACATTGTATTAATCTGATTTTTGAAGATCTTTTTGTATGTTATGTGTTAAGGACTTGTTTGGTATCCCACTGAAATGTTCTGTGTTGCAGACCAGAGTCTGCTTATGTCAGGGGGATGGGACCATTGCATCCTTAGCCATTGTCACAAAATATGTGGAGTAGTAACTTATATGTAAAGCTGTAATACATTAAATGGAAATGCAAAAGCTGTGAAATGTCTTGTGTCTTAGTTCTCTGTATTTATGCAGCTGACTTGTCTGTCGTAACTGAAGTGTGGATCCAGGACTCCTAACTACTTTTCATCTGAATCCACAAGATTCTGGGCAGCTGCCACCTCAGTCTCTTCTCTGTATTATCATAGTCTGGTTTAAATAAACTATATAGTTATCAATGAAG 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@rCer/294/25_1612_CCS ATGGGCCCTGAGCTGGTGTGCAGCATGCTGCGCCTCTGCTCTGGCACGCGGCTGCCTGCGCTGACCGTTCATGTGACTCAGCCGAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGTTATTTGGATCGTAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCCGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCGTTCGTGTGCTTGAAAATTGGAGCCTGCCCGTCAGCCCATAAGCCCTTGCTGGGAACTGAGAAGTGTGTATGGGGCCCAAGCTACTGGTGCCAGAACACAGAGACGGCAGCCCAGTGCAATGCTGTCGAGCATTGCAAACGCCACATGTGGAACTAGGAGGAGGAATATTCCAGCTTGGAGAAACCGCAGCATTAGTTTTTTTCTACTTGTGTGTCTGGGAGAATGAACGCACAGATCTATTTGACTTGTTATAAAAATAGGGCTCCCTCACCTCCCCCATTTCTGTGTCCTTTGTTGTAGCATTGCTGTCTGCAAGGGAGCCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGGCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTTAGCCCGCCCTCGCATGGCACCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGCTTCTTGACTGGAGGCCATCAACCCTCTTGGCTGGGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGGCTTCTGAGGTGGCCTCCTGCCCTGGTCAGGGACCCTCTCCCTTTCCTGGGCCTCTCAGCTGTACAAAGCAGCAAAACAAAGGCAGTTTTATATGAAAGATTAGAAGCCCGGAATAATCAGGCTTTTTAAATGATTTAATTCCCGCTGTAATAGCACAGGGATTTTGGAAGCAGCTGCTGGTGGCTTGGGACCCCACTGGGGCCACGGTTTCTCTGTCCCTGGTTCAACTGTGATTTGGCTTTCCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGGTTCTGTGGGTTTGGGTGGGAAGGGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCAAAGGCCCCGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACGTGTCCCTGGCTGCTGAGGTGCTGCTGCAGCCTGCACCCCTCCCCCGTCTCATAGAGGCTCCTTTTGACCTTTCTTTTCAAATAAATGTGGATGGCGAGTTCCTAGGCCTGTGGCTCCTGTTAGAGGGCGGCATGCTGAGGGGTCTGCTGGGTGTGGGTTGGACGCTGGGGTGTGGGTTGGATGCTGTCTGCAGCCCACTTGGGCACCCATGCTTCTGTCTACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGATACGCAGTTGCTATTAAATGGACTTTGTGAGTTTTGTTTTGCACTAAAGTTTCTGTGATTTAACAATAAAATTCTGTTAGC + JC-JH=JKKKJFJKEJIKFHJKJKKEJJJKJCJIJKIHKJKKEKJAIJBIGKKK*IGJKKJKJJCKKHKJFE?JEHKKKKJ->E3KKKKJKKKDAC;KDFJJHKKKK8HKJKKJKKKKIDKHI?KJE4EKKKDKKBJJKHKKK/IIF9I9JFKKHKHKKGKJDJ:JE-C@JH6ECE;HJKKHJJJBGJIGHJKGKKKKCKDFJFJH@F?KJKIIIG4KJJK4KFB6=FKJKKHKIKKI9KKEKJH>KHJBK?J'JKKJJJKKKHJKKKKKGKKK%=14??IHK8KJJKJKGKIIKFJ4JKGKF%HF@JHC1KKGH=;DKKHKBKKKAA?KJ/KKKKI3BAHGE=9EDEEJKKJHKCJE;GCKJGJKEFKIICK/KKHH/FJKKGK4KKKKEKEIHAFAIJHJJFA?EK@JHCK8KKAJG?FGIJGFKIKHHHI@IJEFJJJBFC<5EKCKKEKIK>JKJKJBJJEHIIJJ3>JDH5FG??D8<6I=8E=DHKKJJ/DHE5KKKIKAKKJJKJ@GHEBK@HKJJK4KGG1KF?G?86IIIHGCIEKEEJHJE?HGCGI-:BIK>H9KJFK,HEKK?IJDKIJ?BDE.H9HFFHEAFIDGGKJJHI?F3JKBHKK>KKIDKJKDKFJ:CJKI8KKAHJKKKK9KJJCDJIJKHHAEB579IBIAG?AEHE1JHD3BF5DHACAKHIJKGF<7IJJIIHKHKJ???KKJIAHKDIEH/@KKKH@HBJJFFKDKJKJ4GHHFEI8CGJEKFKKKKHKKKJJBIKIKKKKKFKKCKKKKKKKK@BJKKK1JJFKHIJKKKJBCKKKIKKKK8KIFKKKKJKKKIKJIKKKJKKJKIJIKKKKFKKJKJKIJKK:KJHKKIIAKKAJJKFKKK>KKKKJKKHKKKKKKKKKKKKJKKKKKKKKKKKKKJKKK8KKKKCKKKKJKKAKKJKKKIKIAKKK@KJKHKKKKJKKEKKKKK)HIK&KKKIKKKKKKGKKKKKKKHKAIKKKIGKJKKHKKKKKJKKKKIKK6KJKKKKKKKJKKJKKKKKKHKKJEKKKDIJKKFKKKKKCKK@FKKKBJBKKKKEJKKK9JKJAJKKK(HKKKKK:KKIGDKKJKKJK?KKJKKKKKKKKKKKKKKKKJKK>KKKBKIKKJKKKKKKKHKKKKKJKK>KKJKCHKHJJJKK?KJKFGKJKKJKKKKKKDIKKEKJKKJKKKKJKKKKKK=KKKIKKIKBH@IJKJKHKJKKHKKKKHKKKKKKKGJKKKKIJKKKKKK=KJKIKJKKIKKJ7KJKKCKJKIJKHKKKKKJIIJEKKKJGIKGJKKKKKKKIKKKEIKKKBKKKKGJKKJKKIKKKKKKKKKKKKFJKJHKIKKK?GJKKIKKKCKKKKKHKGKKIKKKJKKKCKKHKKKDKKKKKFKIJJ=KIFKDKIKKKJKKKKKKKJKKKKKKKKKJKKJKKKKKJKKKKKJGKJKKK9KJKIKKHKKKGKKKK;IKKKK/HKKKKKBKIKKKKKKKKKKKKI?KKKKKKKKBKHJKKIJKKKKJKKKKKKKJKGKKKKIKJKKKKKHKIKIKKKK@KKIKHKKKKJKKKK>KJKKKCKJKIKKAKKJKKFKJEKKKKKKKKKKKK*BKHKEKIKKKKJKKKKKKKKKKKKBGKKKKKIKKKKKKKIKKBKJKIKKKKKKKKJKKKFJJKKKKKKKGKKKKKKKKJKIKKJDIKKKJK5DKKKJKKKKKKKKJKKFKBJJKKK>KKKKKKKKKKKKKKKKKKJKBKKIKKKKIKKKHKKEKIJJKK1FKBKJKKHKKKKEKKKKHHKJ2JKKDKKKKKKJKJK3KFIIKCKJKGJKKIKKKKBKIJJHJHJHH@JKEKKKKKIKKHIKKKKKFKKKKKJKKJI@KJKKKJHKJGGBKJKKKKJKIKKKJGKJEKKJKKKKJKJKKKKJKKKKKKJKKKKIKKK/KKKKFKIKJKKKK/KKKJIKHKKKKKKKKKKK?KIIKKKJKKA:KKIKJ7KKKKJIKKKKKJKKKKJKFKKKKKKKDKJKKKKKKKJKJIKKKKKKKKKHKKKKKKKKKKKKKDKKDK;GIKK:KK6KJJEJIIKK@KKIKJKKKKKIKKIKKGKKFKIKKFIKEHFAK(KKHKKKKK3HKBJKFKJKKGKKHKKK=KEEKJKKKKKKCKJJKKJKJKKKKIKCKBKKKKJKKKKJKKKKKKKJKJKFKKKKKKGKKKKJKKKKIKGKJKKKIJJ@KKKBFKKKKKDKCJKKKKKIBKKKK+IGKK=GK?KKEKKKJKKKKKJ5JKKKJKK9KKKHKKKKEGIJKIKKKKKIKKKKHKKDKEEEKKKKJKKKFKKKHKI42<968;=;<9?4<1826==8:6)3=>978;886>9=49==>18872/86+837860;<64:7.897;=63/1604;=>;3-'221969;>5>>0=09:9=5;:6:<<;<>*:>83:89289;:=79>7=:=;=?>?>5<3=9999<<<7=8<;85968=;:1=<9=><8:>79/>=96:7?65=64586=3:<;=<=:;;>73;=>:==>2:<4=:;9==;?=<66=::9:+:7=;>>>>=5:=9>>64:=8592775==95::818=9425=,9;-)>>:?6;;;>;?>9;?8725492;:;=>);9983<;28?07:>;8=054:9=<5><0=>9;=5<<3=6?;==.:9.:87>==70;<;6286/03058=9?:??6<@?>;581/876:;;>:;A>A<'@@>:31;?8)88:;6?>=23;?7?7>=5=?;A8>><<<>;@@?>3?CB>?>221>9AA:7@?;><<3>;98A?@<;:>CA:=;A:>>@B>?>A=4>B:=><=>@A-C?919:3?>70;725B??@A;6?@5?5&2<::CAB>=B::>@=3@B3?8:==<;5<89>C<<>;<;:=>=7AB?4>=ACA3A@A?713>???A@=9;>==>?=5?8==;?>>+A@><<5>A<=)74999<@@:9:495@A>=@5?>@BA?=AACCA?>>??9A>@2<@:A54<@6?@,9::6@C;:@6=>86;B;??8/7@<9?@=ABA9A>;B>>?>-@;;:;@<<@:>>?@:@;?A@;-?>>=;9>8>;0=9:905.6;9:?;=8A=<>0A;2?=>A>@B?A=A-4A>@;?4A?@>97?:3;+==*8/586364-;<9==<;:@@399<(@0>?82=;>32<9(=5@:=>?:64>A>A=:B=:7<@6?=A>?>A>=9@@@@:<(@A;B@7:C>A8>2?2?<@=BCC><;=A9<418?7?/:3=A9CB:B9?B>B;C9AB>9A9??:4?5CA@BB@7<=7>B6@@A@C@@B>;6=C=AA<846?>=-@AAABAB@@@@=@7BB@;4;>4A?>>>>AA8>:3@:@BB:?<>??7B@B>>@8B=??@4?>AA?AB:A8ACB>:;:AB9B;;@<=@95:@@@7@@=AA.>;C6;?=;C>@=:7@A5>9A?A9B>ACA71>>B?B>:2@AA<4@=>>8@@CB=?7BB=8??87C=5:;??<=,<8<>1=A?;:B=@CB8@A<>>?B@@77=AC@;?=C?@=88<5<@B@B;A>ACA=7=:@@?;@B8BB;>>=A/=CABCBB<>A>B>B><=@>?137=:;8?@>AA>C:CB?@@@A76ABCA8>;>=0?AB>CACAC<=??=;?/@:;<B?@@==C=?==;A@=6@<:ACA<90=?=:@6@2>.<<@=139:>@AA<-@@A<@A<<6A9;4<3<:>7<;ACAA>FCB;E=C@>?E9EA:CEB6?4=B@@F?FFEA@FA@/>CBGGFBG=2@BC@CG1A9?BBA@>?@>DEEEF8C@=@;BCE?CBD;@E:6D:>A>9;A?E:CBB8?FDE;A;EFDC?+?B?:>=?DF?FD/DFFACEG@?A:>?9B3>< @rCer/307/0_2040_CCS GAGTGCCGAGCTGAAGTTCAAAGGATCCTACACCAGCGTGCCATGGACGTCAAGCTGGATCCTGCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTCCAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATATCAAATAGAAGCCTTGCTGATGAGAGCCTGTGAGCCCATAATTCAGAACTTTTGCCATGATGTGGCAGATAACCAGATAGACTCTGGGACCTAATGGAGTGTCTGATACAGAACAAACACCAGAAGGACATGAATGAGAAGTGTGCCATCGGAGTCACCCACTTCCAGCTGGTGCAGATGAAGGATTTCGGTTTTCTTACAAGTTAAAATGGCCTGCAAGGAGGACGTGTTGAAGCTTTGCCAAACATAAAAAAGAAGGTGGACGTGGTGATCTGCCTGAGCACGACCGTGCGCAACGACACTCTGCAGGAAGCCAAGGAGCACAGGGTGTCCCTGAAGTGCCGCAGGCAGCTCCGTGTGGAGGAGCTGGAGATGACGGAGGACATCCGCCTGGAGCCAGACCTATATGAAGCCTGCAAGAGTGACATCAAAAACTACTGTTCCACTGTGCAATATGGCAATGCTCAGATTATTGATGTCTGAAAGAAAACAAGAAGCAGCTAAGCACCCGCTGCCACCAGAAAGTATTTAAGCTGCAGGAGACAGAGATGATGGACCCAGAGCTAGACTACACCCTCATGAGGGTCTGCAAGCAGATGATAAAGAGGTTCTGTCCAGAAGCAGATTCTAAAACCATGTTACAGTGCCCGAAGCAAAATAAAACAGTGAACTGATGGATCCCAAGTGCAAACAGATGATAACGAAGCGCCAGATCACCCAGAACACAGATACCGCTTAAACCCCATGCTAAGAAAGCCTGTAAAGCTGACATTCCTAAATTCTGTCACGGTATCCTGACTAAGGCCAAGGATGATTCAGAATTAGAAGGACAAGTCATCTCTTGCCTCAAGCTGAGATATGCTGACCAGCGCCTGTCTTCAGACTGTGAAGACCAGATCCGAATCATTATCCAGGAGTCGGCCCTGGACTACCGCCTGGATCCTCAGCTCCAGCTGCACTGCTCAGACGAGATCTCCAGTCTATGTGCTGAAGAAGCAGCAGCCCAAGAGCAAACAGGTCAGGTGGAAGAGTGCCTCAAAGTCAACCTGCTCAAGATCAAAACAGAATTGTGTAAAAAGGAAGTTTTAAACATGCTGAAGGAAAGCAAAGCAGACATCTTTGTTGACCCGGTACTTCATACTGCTTGCGCCCTGGACATTAAACACCACTGTGCAGCCATCACCCCTGGCCGCGGGCGTCAAATGTCCTGTCTCATGGAGCGCTGGAGGATAAGCGGGTGAGGTTACAACCCGAGTGCAAAAAGCGCCTCAATGACCGGATTGAAATGTGGAGTTATGCAGCAAAGGTGGCCCCAGCAGATGGCTTCTCTGATCTTGCCATGCAAGTAATGACATCTCCGTCTAAGAACTACATTCTCTCTGTGATCAGTGGGAGCATCTGTATATTGTTCCTGATTGGTCTGATGTGTGGACGGATCACCAAGCGAGTGACACGAGAGCTCAAGGACAGGTAGAGCCACCTTGACCACCAAAGGAACTACCTATCCAGTGCCCAGTTTGTACAGCCCTCTTGTATAGCATCCCCACTCACCTCACTCTTCTCAGAGGTGACACCAACCCCGTGTTAGAGCATCAGCAGGTGTCCACTGCGTTGTCCCGTCCAGCCTCCACTCATGTCCATGGTGTCCTCCTCCTCCTCACCGTTCGTGCAGCAGCAGCAGCTGGCCGCTGGGGTTACTGCCTTTGTTGGCAACTTGGGTTACCTGCCTGTAGACAAGTCTCTCTCATACCAACAGAACTTCCGGTACTTCCAGAACCAACTCACCTGACCTGCAACTCAAAGGCTTTTTTTAAGAAAACC + @4?;=2::4579C;CC;A@:?@4:?BDGAEC;:DCB4D.A;BA>;?DDBFB5EC@7/>6;<;;6590-8?<>=>?CB>;BA?BF1A?3>:=6D>ADE866?.?;BE>FDF@B@D@::7BC8>@@A9?=F4A=2B;AE?6<,>=CG<>E=A235(BA5D1C,CEA)8@8'@BDDDG;A@A?FE:FCEE=B4BE7BFE?C872A90)DB4?>D*>79@?;F>E>0ED>>5;:<4B.:<459B?DC@2)*?+7=7@?G88D3C>BBB@6GCDE?C2C=EB?BD:A>C>:@:6C9EA*B>?7C-DE><6@883<@+>0:CFBAA38DFD:>>;=2EBA9A8,;>6?,@>>FA;82>>AAA;0??D@CG>EC<>D8=>?B=B?EEDEC49?FDE?E9D==G2A8B7873=779ABF2=57E>=?;=A@8B>:>>AEF>;CBG>@A;CB-<>6>/./82&8=<>A?DD>A9?3CDC5EGGFBE@A=?FFADFE<=@B=A-A;F;:7:2@=@*@BAA9DE5ABDAD??+ECE?=DB=8*043?(B:B+@?<8C:FB@DB;CB7A8@FDAC7E?ADF;BB8:?9.77AB?AEB=7GED71@4F=7EF>>DC3BBC8EF<;///AF:4@4@@:EDA@AF:GBC@@1D??;@@C;8;=CBED?BEEBD5E@>D>@BGD82>:<><@5$)7EB=2>3E?(5596B=?+:<=+A?6?ADCA6A@?@45:@>?9A?E6=5B898:-@@C=)>?B<@/>>B@80@@;B<868;=EBA>C>>69?CC1B::13>=?,>??DD<@B5D;BBD,DDC>BBBCAFAEG9BFDA<@?5?@A=2:C7?@B?@FBE;D:B@2=D+DAC?2GFEA=:9:29:1A@@(>84/:=@E??>8;;4>A9;;C:E@DF8E=>C>7A>?CEFC?49:?@BA>0E<4**B/?BD+A?FA?;CAF?@85A?D@A:A@FDD>G;5D<@1D?C8FA?FB2C4B>C6A.DDC>@?CD'CD@AEGF4D=B5D@;2=F5=A+?B4?79B7/A98:F8AA;CC?/AD&=83D*>@?8>A<<;AB%9=>?C9D9?%488?A?=?25?B=?@AAB/ABCE:=@;BA8>B?>?D>BE=BA>ACCBC@?@AC?@49/BA*<3??C@:E:F::7B;@A8BAFAG*A;=7B8DE>EIHBJIEEHJI:FE@B>BEJ=HH?J=?E=FGCGHKFDFHB@=4,=4BED36EF>6@=BBF:D/DCBBD;E:>@ECGFCD?CAGB/?=F>E6G@9AF=EA?DJAEB7E?GE5F=?F/EE9@@)CIIIFD5?G1EFH9F @rCer/308/25_1569_CCS ATGGGAGAGCTAAGCGGCGCTGAGCTAGTCTGAGCAGAGCCGGGCGAGTGCGGCGGCGGGCCTACAGGACGCGCAGGTGGCGGTGTGGACATGTCGCACGGTCACAGCCACGGCGGGGCGGCTGCCGCTGCGCCGCCGAACGGAGAGCCGCCGAGCAGCGCGGCCTGGCCTATGGCTGTACCTGCGCATCGACCTGGAGCGGCTGCAGTGCCTTAACGAGAGCCGCGAGGGCAGCGGCCGCGGCGTCTTCAAGCCGTGGGAGAGCGGACGACCGCTCCAAGTTTGTTGAAAGTGATGCAGATGAAGAGCTTCTGTTTAATATTCCATTTACGGCAATGTCAAGCTCAAAGCATCATTATAATGGAGAGGACGATGACTCACACCCTCTGAGATGAGACTGTACAAGAATATTCACAGATGTCCTTTGATGATACAGAAAGGGAGCCAGATCAGACCTTTAGTCTGAATCGGGATCTTACAGGAGAATTAGAGTATGCTACAAAAATTTCTCGTTTTTCAAATGTCTATCATCTCTCAATTCATATTTCAAAAAACTTCGGAGCAGATACGACAAAGGTCTTTTATATTGGCCTGAGAGGAGAGTGGACTGAGCTTCGCCGACACGAGGTGACCATCTGCAATTACGAAGCATCTGCCAACCCAGCAGACCATAGGGTCCATCAGGTTACCCACAGACACACTTTATTTCCTAAGGGCTGGCCAAGGCTCCCATAGAGGTGCTGTGTCAGTGAAGATGTACGACTACTGTTGGAAGGACAAAGGGATGAGGCTCCACAGAGAGTTGGCTGCCACAGCCTCTGCCAAGCTTTGTCTTTGGGCTTGCTGCAGAAACCTGGACTACGGAAGATACGATACCACTGGGAGGTTGTGTAGTGCCAGGGACCATCGTTGTTCTCTAGGCGCTGTGGAAATTGGGTCTTGGGCTGGTAGCATCTGGCAGTCATGGATAACGTTTGCTTTTCCAGTCAATGTGCCATGTGATTCCAAGTGTCATGTTGCTTTGTGCAGGATTGTTGTGTGACTTGTTTTTTGTTTTGTTTTGTTTTTTTTAAAGAAACTTTGTGGGTTATAGAAAACTTTCTGACGCCTCAGGATTGTGTTAATAGTAGCCATCAGGAGGGTCTCCAATTAAAACACTTGTTCCTGCTTGCTCCTTTCCCCTCTCATTGTTCAGCATTCTTGTCAAGTTGCCCAGCTTGGAGTTGTCTGTCACGCACATGTGTCCTGTGTTATAGCTAGAAGATCAGGAGTCTCCTGCTGATGCGTGATAGCTTAAGCTTGGGAGAAGGTCTTTTCCACTGCCTAGCTAAGCAGTCTGGGAGAGCATGGGATCATTTCTGTGTGTGTGGGTAATCTGGTCGTAAGATTGAGACTTAGTTAAGATTTCCCTTGGAACTTCCTTAATGTTTATTAGCTTCTAACTAGTGTTGTAAGTCCAATGCCAGAATTTGGAGATCTGAGTTTTCTTTTCATGGCTTTTATTCACTGTGACTAATAAGCTTCCTAATAAATCCTTGCCAGAC + BF0IKGGHHJJHKKK@KKGKJKJJIJJ9JJ@EKJHJAJE=K,KJ=KK1KK6KKKJK'CFIHKIHJ0HE;IJC?(;;F@IEF5AICFGBB0IIJJIEIEKIK9IA,HJII>FKKJCK:G?HJKJJD7KJHKK6KB$IHAHJ-I=?:JGGKAIEK'ID,K&KKKK77-H9KKBKKKJJKJKKKK?KK?KKFK5KGFJK@JIK2KJK?KIKKGKK>JKKGF2GKKKKK'K'FHJ@KKJJDJKKGKGFKKJ5KKJ;GGKJKH%JKKKKIK>KJKK>KKKKKKAKKIGJKCHKJK7DKJKGJBB>KJKJ/KKGKJIEK9KKGKKKKFKJCKJKCJKKKFHJCKD*IJJJKIKKIHKJ,H<@H:EIFIKKKKJJHAG?0IKIJJKKKJKKK@HKIKKKKJKKFKIHD>#KKKKKKCDKKGKKKKIGKJKKJB-IJ-IIGIDJFD3FKEHF2KGKHJFIG@F?KJI-JJJHC=JDJJAIJFKJIKKKIKDJFEKJHB$EBE9=KK=JKKCKKKKJ-KG?JKKKKK8KJKGJKKGKJKJ?CJ4AKK%DEJKIAEKK@GFIIE4JKKGKKH:KK5KJK4JKKHKHKK/I'IJJFBBHJGKKJK>JKGKJFKFFKKJ9HJKKHK?>;BJKH&CKKKK@;FIBKJKKCKKKIKIHKFIFK%HB:FH.9B3KIKJ2KKGHJKHIH4IJKC&JJJIIHH;KKFFJJJ*66GIGGEA>BJ4GKGKI=BH=EJFKJI>#FH@K*J9H:KKHAKD6GKKI6K5K7>,CIEAJGJJKBKIKJ@G2JFJE<'GGGFK/JICK=H@;??JK;7KKII&J;>*I>DEHJDA)=E5GI%IKI:KJJHFEKI+KJJKJF@K=JKJKKGK5IJCI,KKKKDK,KGBF+H@JG@KCIG,KKJIIE@K>KKKDIFE?JJKJ?KKKEKKKGHD?CHE'7IHAJ@=@FK(J@K;JCGIKDIDKKJFG*KKKFFH9JKKKBKIKI'IKJJFKKHKE$8HKK6KKJJ@KKFKJIJK.KJDKDKFGFEIKE?DGJE@KJHKJ@H=JFIJJBGIG?KHJ5J6I@,IKJKFEKKKDK8JHHHJJIKJJKJJHJKJKFHKEH9JK&KKJKBGJKCKJGKHKKGKBKGIKKHKHK>EKGBKKJKK?K:KKJJHKEJE1IJHGIGIJKKKCJG+==<:(CJIKKE??JJEHIJHKJAKJ/JKJKKKKJKJJIHJCC>CJ:@BEKBKK??A%IK?HBD2KKJBKKICBJJKK2KHIJJKKKJKI;AFH9KJGIIFJKD3H@FIJKCFKG0HFD@3C=G3=GAHIIKA8IKH%IJKIK9KJKIKI>KKKKKIKGI.KK0KKDKKK>KJ9K?KIKKKKK+KKJ@JJAJFKJJJKJII:IKEKDJKKHHCKJKF76KKI=K@KK4JKKKJKKKKH)%&HD8KKKJCH9KI8KKKKGKKJKKKKKKDKEKKIKIK=KBKKJJJ7KKIBKKKK(KE=KJ @rCer/312/2688_59_CCS ATGGGGGCGGGCGGCGGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGGCGGGGACACTCCCGGGGCCGAGGACGACGAGGAGGACGACGACGAAGGAGCGCGCGAGGAGGACGACGCGTCGGGAGCGGGGCCGCCCAAGGCCGAGTCCGGCCAGGAGCCGGCGTCCCGCGGCCAGGGCCAGAGCCAAGGCCAGGGCCAGGGCCCGGGCAGCGGGGACACCGTTACCGGCCCAAGCGGCCCACCACGCTCAACCTCTTCCCGCAGGTGCCGCGGTCTCAGGACACACTGAATAATATTCTCTGGGCAAAAAGCACAGTTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCTGAAGACAGGGGAGCAGACGCCGCCACATGAACACATCTGCCTGAGCGATGAGCTGCCCCCCAGAGCAGCCCCGCCCCCACCACAGACCGGGGCACCCTCCACCGACAGCCCTTGCCGCCGCAGCACAGCACCCAGATGGCACCTCCGGGGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGCCACTCGCATCGAGACCGAATCCACTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAGATTCTAACCTGACCCCAGTGCAGAGGCCCCACAGACCCTGCAGAGCCCACCTCGCCTTCCTGCCGCCCACTGAGAGCCGGATGTCGGTCAGCTCCGATCCAGACCCTGCTGCCTACCCCTCCACGGCAGGGCGGCCACACCCCCTCCATCAGTGAGAGGAGGAGGGCTTCGACTGCCTGTCGTCCCCAGAGCGGGCTGAGCCCAGGCGGAGGGTGGCGGGGGAGCCTGGGGGGCCCGCCGCCACCTCCACGGGCATCTCTGAGCTCGGACACCAGCGCCTGGTCCTACGACTCGGTCAAGTACACGCTGGGTGGTGGATGAGCACGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCGGAGACTACAGTGACGAGAGTGACTCGGCCACCGTCTATGACAACTGTGCCTCTGTCTCCTCGCCCTATGAGTCGGGCCATCGGAGAGGAATATGAGGAGGCCCCCGGCCCAGCCCCCTGCCTGCCTCTCCGAGGATTCCACGCCTGACGAACCGACGTCCATTTCTCCAAGAAGTTCCTGAACGTCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCCGGAGTCCTTCGGCTGTTCTCCTGCATCATCAATGGGAGGAGCAGGAGCAGACCCACCGGCCATATCAGGTTGTGCCTCGACACGAAGACGAACTTGAGCTGGAAGTGAGATGACCTCTGCCTAGTGGACTCCAGCGCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACCGGTGCCGGGGCGTCTTCCTGCCTATTAACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCCAGGCCCTGGCCAAAAACAGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAGGGCAATGACGTCCTCTGTGCCGCTATGCAAAAGCATTGCCACCACCCGCCGGCTTCACCGTGCACTTTAAACCCACCCTCCAGCTGCGTCCTGGAGATCAGCGTGCGGGCGTGAAGATAGCGTCAAGGCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCTGTGGATATCATCCAAAGAACAACAAGTACGTTTGGGTTCATCACCAAGCACCCCAGCGACCACCGGTTTGCCTGCCATGTCTTTGTGTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGATACAACCTGCCCCACAGAAGATATCTACCTGGAGTAAGCCGTGCAGCCCCGCCCTCTCATCCCCGGCCCTCAGGCCAGTGCCAGGACAGTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCTACCACAGGGATGAGGAAGTGGGGCTGCTGGCCCAGGGTAGGGGAGGGTGGGGCAATGGGAGAAGCAAATGCGGTTTATTGTAATATATGGGATTAGATTCATCTATGGAGGCAGAGTGGGCTGCTTGGGGATTGGGAGGGGCAGGGCTTGGGGGCAGGCCCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGCCCTGCCCCATCCTGGGCCTTACCTCCCCTGCAGGGCTCGGGCGCTCTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCTTGATGAAGCCTGTGCCACCTGCAAGTGCCCACCCTGCCCCTGCCCCACCCCCACCGAAAAGCCGTGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACGTGGAGGTGAAGACCCCGTTCTCAGCCCGTCATTTGCGGACTTTGGGTGGCTCCTGCCACTGACCTCACCGGCATGCTGGCCTGTGCAGGCCTAGGACCTCAGTGGGAGGAGGAGCTGCCGCAAGGCCCTGTCCCAGCAGGAGGGAGGCTTCCTGACTGACACAGGCAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATAAAGTGCCATTTTCC + (,-*)-(+,((**#**'+('$(''(,%,--*,&,)--,.-.,-,-*++)*()-----(+*+,+)+--+$+,,$)-)+()-+,&&+%(,($%#+,)&((*,(+('%$()(-*$+*,--+%,)),-*----+)((,(+(&&&#"%),-+&-,)*&,',)%'&'('-)-(*-+-.,-,-)**',-.-*(+,(+)'-+.**&'+-).+),+*-&*,,,.,)--*.,'*-(,,((#$'&'(*,-*--)&$,-)-**-+++&,((,*'+*+,.**-*-+(%#)(-)*-..++,,*--,,*(+,',--+''',-,--*-*,&(*$$$)*)'('$&%('(,($")((+-++$)&',*(,)+..*+-*+-))',-+*-++((&''&,.-,+),*)-,--*#*)*+.,-.,$$&#**'*-+*%%**&&,,--+,------+(&+++)$+(+--,-..*',,,--)),&)+*+++&(%+&)(*'$*-),.,(,-,,,)%(&,)%&*)-,(,,)*+($)&,*(,-*-),))')+*+**(##()+,'(+)+-,,.+-,,-----(),-)&'+%$&),+------,&-)--)+.--'('+'%*'*&'*,))*(&(*)&)))%+#,-)'(-,,'%&%&&'%-%+(,...*+&,,-**('&,--$#&()-..-,-,*'))++'((''#+-,,-.*$++(-***,,,'(,--.-.+'()-,-*----+(,(%+'+'+%&,,&)+)&$')-,-()().(--+(+*-.+-.,*&&((''&(#'-*--*-,(%$)')$)()---+**$++(+'+-)%,+-*+***&*,*(+))%,*$)(&'#&(&+*+)-*'+-+--,**&$&-**-++'%$%(%(,+,,'(-,),(&))+&+,+(,)(((((')+'---.,-,')*$*+',(+*')*,)**'((,,+&%)(#$(*&'*$,*+))))+(,+-,*)('('+,&-,,),&&(-*&((*),'+$,+-++**-+,'**--+(+)((')+--(-,),---*+(*))-+--,,----,.+---,-,*)),,),)+),-,-*)+&(,)*--,,$-('&')')+&-,.*-(&)-,-+(%''&'#)#&'#),....)---()--,--,)&$)-+,,%--+*+-*)'),,,',%&'*('*),,,%&,.+*##*&,.-,+'**%),&,.(,,()*),.(*%*((-.*-(&&&'+*+(---,%#,&*+-.)''$'--.---*---)&*-+-+*%&-)()(()&+--*'**)'*,.---)*#')),+%,,*',$+-+,),+*,(()&,&,(+(-,**(+(,,,-*,,)($'&%(,*+#')&(($#'$%)&$'''%'&$'$%'))(($((&#'$'))('&&$%(&$)$#$'))('%$#(%&$%$())&())((%&&$$('&$)$$%(((%''$"#$$())))(('#"$$&#&%#()'%%)(%$('$()'%)(&(&()&&)')))))($&%%(%()(%&)()&'&#(($'&(%(%$&(&%#%#&'''((&%#$$#'%$('$#$)(()&$''##()(())%('&'(&'%&(()))('#&'%')(((%'))('($%$''#'&&(()))(%&($$&$&(%((&%&)##%$&%'('%$%(()))((%'')%'(()&%$(()))&#&%(&'&'(&$$#&%%%#((($%)&&&$)(&"&()#%$%((%(%%(%($()))()())($(%()))'&'&())&))))))&)')))))'%)(&)())&'(%()('$($#))'))&)&%(('))'(%()&&%$%%$%'))&((&(%&)%()'(%)&&()(())&(%((%('$"$&%**&,.-..)%((&+*$+,+*&),+),-,)(,,,(+'&$+,++---.--,,-.)---,--*-,+'##$&$#+'+-,+)$(()(-)--(++,),*+-,)(*'*&*-),(,,-,*(*,,,+')%"*-*,*+#'(*-)+-+-+)(*',-.+-.-*-,#+-+'%,+---,-.--*%(-',*,((++)*--)*+)+&+$-,+(('(,)%#(,,$,--,.,)%&)'*,#%,-*(-,..,,'##&'+(%#()-&)(*))%"$+*&&*&+%,,,-)*)++(++()*,-(+%(*(**--*-*(-+',((,)*),*-+')#*&)*+''&$&&'%##')(%&%%,-'#*+,'),',(-.+,*++#,+-,)'%+'&)'-)+'*,(,(*'*,.+-.+(+--(+(,--+($+,*+&+),(*-.-,*)#-+,(,-,*('&#$&#&-,'*,-*,(----*--(+-(,--.+,(-,)+,(),-(----+$+,-(,')&(+,**,'(-,))')+%,)-.-,+,*%$&%&%)(-,-)-),-*&$%++*$(-+(+))(,-),(,)(,--+-*(*-*'(('().))+),+-(*,-+$"'(%+((&*%-.-.-(*)'+,()-,$+-),-)())'%$'*($&+(,,--+#+,,-*$,.,-,-&'&'*$*-+))**,(())-)--,(,.+--,+)-,(-+*,,)(+&'%$&++,))()&),-*%--+&)*+$')(*-),)--*+',,*+-+-,&*(+,,'+%+')%*-.,,-),(#,&,,*+*)---+),)#*-++*$')$($$&,.,*&'(''$&',(---',%'()'(-**-*-('***$-+ @rCer/313/0_1361_CCS CCTGGAGCACGCGCGCGAACCAGCTCAATCAAGAAGAAGAAGGAAGAGCTGGAAGCCAAGCGGCTGCAGTGCCCCTTTGAGCAGGAGCTGTTGAGACGGCAGCAGAGGCTGAACCAGCTGGAAAAACCACCGGAGAAGGAAGAGGACCACGCCCCGGAGTTTATTAAAGTCAGGGAAAACCTGCGGAGAATTGCCACACTGACCAGCGAAGAGAGAGCGCTGTAGGGCCAGCTGCCAGGCTCAGGCCACCACCCACCCTGGCCTGGACACCCTCCTCCAGCCCTTCTGCACCTGGCAGCCCTGGGCCCCAGGCCTTGGGACGTCTGTGATGTTCCCACCTGCTTCTGTAGAAATGTGTCACCCAGAGGGCCTGGCTCTCCCTGGGAGGCTGGGGCCCCTAAGCTCTAGGCTTTTCTTCCAAGCACCCAGACCTTCTGCTCCACGAGGGAAAACTTGCATCCTCCCTGCAGGGGGTTCAGAGCCCAGCACAGGGGTTTTCTCTGCAGAATTGAGGAGGAAGAGGCAGCCTCTGGCTTGACAAGCCTTCTGTTCTGCCCAGGCCTTCCCACCAGGAATCTCCAAGGCTCCCCAGGGCCCGCTTCTCCGCGCACCCAGCTCCTAGGTCTCAGAGAACTCCCCCACCTGCGATTTTACCTGCAGCCAGCAGAGCTTAGCTTCAAGGTCACCGCCTCCAAGCACTGAGGGAGGACGGGCAGGCAGACCGCAGGTGGCCTTGTTTGCTGCCATCCTGACCAGGTGGAGGACACTAACAAAGACAGCTGTTTTGGGTGTTCTCCCCTCACCCATGCTTTCATCATCCCCTCCGCACAGCGCCACCGCCACCCCCCCGCCCCATCCAGGCCTTCTAACCACACCTAGCCAGGGCTGCCACATTCCTGCGCCCAGAAGTCTGCAGCGTGCCTCACAAACTTGATTGTGCATGCAAAATCACTGGGGATCTTGTTAAAATACAGCTTCTAACTCAGTAGATCGGGGTGGGGGCTGAGATCCTGCATTCTAACAAGCTCCCAGTGAGGCGGAGGCTGCTGGTGTGAGGACCATGCTGTGAGCAGCAGGGCGTGGGTGCCCAGGGCTGGTATGTATTAGAAATTATCACGCCTGAAGCCATCGCTGGCCCCCACCTCCCGTGGACTGATGCCCCAGGGATTCCCACCCCACCTCTGCACCCCAGGTTTTCTTCATTATCCATCCCACCCCAGACTCCCACCCCCAGGAATTCTCCATGAAGACTTTGGCCTAGCAAATTGTGTTGGTTATGTGAGTGTTGTTTTAATCAGAGATGTATGTGATGCCAATCTGCATTCTTCCAGTGTGACCACACTGTTATGATGCAAATCTAG + S%(()'(%#%%$#$%$+12121-*10%/0-0/1/5..600634.6542.-06/43,3)/*+-/'2462/.(()/*+,1-,,,/10-0/-0(00/,110.1-10111+.1*/),/01+0110(1100,-',10201,1'012/0.-/*1-.,(./1/,+,/.20+0%/./1*.+,*(***))*-.*./--*&.+'+,00+'.--0111/%/*)'*+(+,10''')%01%)11-/1+1-*-,*11,1%..*1/,10.(/,*/2-1.).-01/20/-00/2+-'-**20,-.012,'00,-)11,%(,%.-+-1/.2+1,1/),*..++*,.)-&.%/2+&.*/&/2,+10.1,,1-+-*.,)#,-,00*12+10-100+/&/.//20/+,+0+000%/./-.2.*+&*)&.+-12,&,1/-.21--)1-''&$$'0.+11/*0%&,,%.-%+,-+,.-'*0&0*%.01/1-'+.0/,1111-,+2/$)*'-+&-,-$,0.//*(%-*)&+$.-,*.'-1++'--.1,1)1'*1121-11,0-20,--0//1.1'*)&+/1/2,.'/*11+,1-1211,0--,-2,0*,(0111,22)0-.++10.,-/.1,/*-0,,)--00,-21--,*010.,+%$+++-00211.11&.1,'&01--,0)1,1111.+*%,*.1-0/,.-21..%-,&.001&0.-/,+.)"'%'&,-0)1,),%//-,.(/,/112-&-/2%*'#*,.*&,+/-)).01,,1-%-.&0-&0.1-0,-210221.-(-1&0&/0.+02'.)//.(0+(..0(./)010-120+0.,0#-,,/020--10-*'$-*./-'0,#*('(+/(*111.'(,///.2/2,($.+.&.-,2-/,,.,*-..-'&'+0.+)..%--*$-/00,2+./(+1.,+$//,/)-.,*11/02.102,.*0(,+&%(-0//-/0&0//.')(00(1'././01&0*,).*%(&).1.+0,,/+"--,)%*0.)(,/010216165+'1*./01(/3-2.5.-$,2,3352650+131/1-2,/+)0'/'&)().5-5121*.244.+1-%,+'-3//0663)43,-+2/41304250/%22%0.232/.++/1-5/)420-30,04$/0/.,'1,'35/**10%,+121(3132-243%((+0..2440$4-202/+&0233%))345/)-..*33))200,33-(300./4*&,442(35300(,&,(*,)(1155+.0.4&..'3'1.144(0**.+-/+/02,2+-/00*,+-*/+&*++&+(*(('&$&.0,,)//(*+$+(1)''*)+%*))*$/()--'*.*1(0+)'+&-*+&'&++(//*)''% @rCer/314/1517_55_CCS GGTATGGCGTCCGTGTTGGGCTCCCGCCTGTGTTCTCTGGGGATTCACGTATAGTCCCACCATCTAGGACAGGGCTGGGGCAATCCAGCCTGAGGAAACGTCAGGGGAAGGCCCAGGATCCACCGCGAAATCCCTAACCATCCAAAAGGATCCGCGCCATGCGTCAAGCCTGCCTGGACCCAGTGGGGACATTTAAAGTTCTACAATGAAACCCATCGGAGATGCAAAGAGAATCGCCTCTGCGGAGACAGAAAACCCACAATCGAGCATCATCAACTTGCCAGATAAACAAAATGGTGATATCAGAAGAACAGATAAAGTTGCCATCCACCGAGAAAGCAGAGCCGCCGACCTGGGCCCAATTAAAGAAGCTGACACAGTTAGCTGAAAAAAGCCTGAAGAACACAAGGGTAAAATGAACTCCAGAGAATATGCTGTCTGCAGCCTTGATGATTGTATCAATGGTGTCTACAGGTGTATCCAGCAGCTCCGAAGAGACAGTGACCAGTGAGAACGGGCCATGATGACGATGGCGGTTTTGTCAAAAAGAAAAGGGGGATATGTAGGGAAAAGAAAGAGAGATCAGACTGCTACTGTGTCTATGTAGAAAAGGAAGACAAGAAACTTCATTTTGACCTGTACCTTGAACAATTGCTTTGCCCTGAGATGCTGTTAATCTGTAACTTTAGCCCCAACTTTGAGCTCACAGAAACATGTATTGTGTGGAATCAAGGTTTTAAGGGATCTGGGGCTATGCAAGATGTGCTTTGTTTAACAAAATGTCTACAGGCAGTATGCTTGGTAAAAAGTCATCTCCATTCTCCATTCTCAATAAACCAGGGGCACAATGCACTGCGGAAAGCCACAGGGACCTCTGCCCTGGAAAGCCAGGTATTGTCCAAGGTTTCTCCCCATGTGATAGCCTGCGATAAGGCCTTGTGGGATGGGAAAGACCTGACCGGCCCCAGTCTGACATCCGTGAAGGGTCTGTGCTGAGGAGGATTAGTAAAAGAGGAAGGCCTCTTGCAGTTGAGATAAGAGTAAGGCCTCTGTCTTCTGCCTGCTCCTGGGAATGGAATGTTCTCGTATAAAACCCGATTGTACATTTGTTCAGTTCTGAGATAGGAGAAAAACTGCCTTGTGGCTGGAAGCGAGACATGTTGGCAGCAATGCTGCTTTGTTACTCTTTACTCCACTGAGATGTTGGGTGGAGAAAAGCACAAATCTGGCCTACGAGCACATCTAGGCATAGTTCCTTCCCTTGAACTTATTTGTGACACAGATTCCTTTGCTCACATGTTTCCTTGCCTGACCTTCTCCCCACTATCACCCTGCTCTCCTGCTGCATTTCCCTTGCTGAGATAGTGGAAATAATAATAAATACTGAGGGAACTCAGAGACAGTGATGTTTGCAGGTCCTCCATATGCTGAGCGCAGGTCCCCTGGGTCCCCTGTTCTTTCT + %%%$.-*.'-0.512938;55;-8705:3<><3776%4?;::4&33&32989,-201&2,09+62=5:4<8461(24368548=7>;8;075+8;9:5342'0*11<0798,5/65;;89;8<<:27=2582622:<0=883/%547796:<510;27940,-*0-2/&332162*3655:96989=<;<<86()/&(.1484/3$441;:>::1=9;98:.*4984'75953//-69=7-41A?:5<>.:6-:>>6B9.8@@9>=<84;3A?4=5+%6+4=B4;><@.B@6;678?99<362==:5=@==6@4997<=94@9=AA>3;=@8:64:=B;3><@+99(D9A;;9)2=998;?A?====::?9B>,78<=6?;A9D79D9C5<3A9?B?C>6;9679.8@E?4-<+220237?;88&3;6:0155<<3;9;<21160,;;5;47977=3;/9=C754:/9>6<4.@BA',8>>@<;6?@??/6:=526:1:;77?96>@?6?B9;:6/28;9@;>:@8@74<98<7@?@99>70+324&=409:3.21;8?=::6:<2>0:8-:<497=:A<13:?&9<:928;3899)844B@4@0989%:78>C>:?<9=6=>3>:6=54=>&C=?6;A;7=::0*0164-7&;3/6@A2=>;>-<;:>67;;61;20:689868>?,=8A?=@@B;6<121A:?<1880<.><>1?=>6BA6A:99,69103/79/064+7412A@B<747,11,:=;/6<27=,35(<3674@608;/694*33'88045&::=><;7>77>.>7>=.?/?<=/63=78:-<6;;25:1.@;=:A=>;;705/*2+177<67949/617924<1;783638651.-6738><;@4?B=387A@75;8@.5966?A8:<48<:<670/3:3<@?:=11+4:;>5:B?6A:;7<4?4<=6<9.8-&/'+%*/*269$,2,8>6-8-98.3:<1536,1689;69<:350.814/90.1988,6*81<8;<@/@19@;@>9%3=<=5?:@==29:;71,26=8,7:;6?-*;C743:;5?<64*3*,7#+1,/-9611+3/1(22&233624))/057-/954796,/(-1.*-2'%,-4&)835,&/1+.*2503/-2248+/.57)29894113:538418:9645335543*51%/:2+,24:43/66,-5;48:341::45:885477751+//-'375*19564:910102&79 @rCer/316/25_2184_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAAACTGCTCACTACGGCTCCCCTGCCCCAGAAGTCACACGGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGTTCCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + >=2>826:7,838*7(348-84716:<:28/<72>9(97>=404:580:**-661))(0085*'/-21)41.871390,571@4/839*.)::3505-/78?1<6571<654*573).49.3<>=51=88@3:352<.:5>1(:8;*:5,0/1:66:B9-<:77:989:A>9B+>@25.?@;<><><&4/'+),008;=8'1-02282-972867,75@8?:90<:6@:=86.363=7A3663.:4/69%036;:=6=8=-4-'-1)%/0$%;9;5@6554;5/0-20)/4;@4B8>3?CCF>9:=-:;?-:=29=;C4ACB?=16@?<>1;>>DAD2=@A;C<7987BB?=;5468?;<567?89-3=@<)6@==@?:04;974+9:1=;CFAD73=;::@9?AB)>E8:>3>AE?@<=36(31'770-47:,;C@AA96A58<<(:56=/>:5<>?9/C<8?:7/44758C@7CA?;@>1:5A9A;;><=)-.41.9)27928=7405>C>(,&77/>83>@<88=AEF?;@:<9087570>@@B2>=C1;<@?%<1@*197.@6>3>8:?735BGC<8;?17?@B@?CAD9@EFE8><;93=/38BB=DBAE?@C@=692.33>=68>3?<=84;=?:@:3D24(C?2=38A>;6<6@2>:-:)<77>7=,035:9;5+4)<54=;-A<=;AF?;6E@@A4A8;>B?@5099E@82;-89561,;7ACDEA;B:;:9B8B>@;DGC91;;>@AB5=8>6$87*236;DCD5FG?)=:=7/<>@;=A$'@EEB@*4>8=FEBFE7:CEDCF:<@F@DC5,10GEICAD?04;>:=?@EFI*@C>;DE>ADCCA:>8609B>==BEAJHG:<:9C=BABG?7B4FIG:@D@A>'@A>7@779>HE?FCDD=;CD7?0<;(*:9E@C97@=<&><:;65G=??6=4-CFGB@:?D9E/:@F<;AE6HB@=D:FFB57AE9E;:A>H?C1@>DD7DD2E?A@AEE;=A8E=BEAC:2?2@=D=@DAF>BC9?GD=BDB;52B<;BEB=A?DBHHG8=>AEDIE4F:<@B:7:A>@C8@>H@7;HEB=6C>=6@IE>D>E=1<5;;B=85><;8?6?CC=A9?=?B:@DCAEH@H:1CFB?CG,B@E?8@A5IH?C>;;<8DFI?@:BCCECEB1D;I?D;>DCEF<9=E@=;C?F;FFHADH?B-<0=A<<;8>DCB8EHIGIDE;?@@?/=1>?9=@EFHDF:E3CC?DFDIDF8-A@?A9HCC>H3=6<0?@EDD8DBBGBE>>BB>7@F?=FFBF?GIE@E?>DIE=<(=HHD<4;=:<0>;;?CCDIC0BFC3<<88>:?ABG6DC4IHF7B/DC@;>2:B>CED=AB>G1GFD9D>E6D;?3:FDIGGDH>86CF3=68?;;DADBEA?:EE<=@E7ABA2D8B799:@890@?,><=C>:CA@6/'50<8:=D?799=CEFD=@B?9?5<;><79=EB>A;=:AED<>2=EGD:F9:AEBEC+>7>>A;E>@CBHKGFA9EGI>KEKEKJKHKIEKJCIGBGIHEBHHKBKIHGJEIJIICGCJJJEKAJHJKJJFHBGJI@GEKKIJJHIJFCJIKKFGKAJDEHHF59FKJJCIKG@;IKJI.JIHHFIFG:B13GJAKEK?@IJHJHEHJKAA9GIKJHJGGEFI6KKKIH@KJICHGBJI:KJHJJ=JDIHK?GIIBI5JKIGHFHHACCHJHEKGGJ?IJB:EIJBBBKKHHKGEJFAFGHHJKIJEIJHA?FHKJEKFI@K@JJ8IBKI:EKDKJDJKJI?KKJJJCCKKIJJEKIHIJ=I@:KAHFKHKJKJG>GHG=IFB;CJJI>G9HHIIIJKGFHCE?HGHIJHG4JFFGGKJ41IH?HI=IJGFIIIKJ>KKKEKIJ@FFKKHJ6JJDJGIJIJG@IJGD>IFHKIGIIKKHKKCGHH>>7GFFHGEJKGFIIIEIJH?FFKHF?IH<@IA@GFKJJHADJJF:JCI8D8JCIEHFKFIFJH=JIJ@IGKGIKGJHCKDGEFCG<>EBHHKKJBG?JIGJJ%HIIJDAKFKGDCHH@KJK?KJJIJIDKGKHAFIFK?KIIKJIJ2KHJKKKDKH=KKKKIFKDIJGKJJ@KIEHJJKJAIIBAII)GIIGIHIHGBGKIJKGJJIHJ>HKKJKJKJKIJJJKKKJDKJHGIFKI>KKKJFKJKF&HKCKIJKKGIJF:JGIKDDKHJCKDGGIKKJKDKKKIGJJJJKKH2JKHJ2KKJKKKKII?KKKKKKKKKKI9;9;8+182.43549895=25;18:5:12:=976884,$10*+5<495=/1642(3::7396:7=9;698,)8199<>89<.13:40.+9?9?32=8836<>-?9;<;=:3=:97/.5;%7;83-:;3=>;:85>8>91;:>;<:>;542742/*/9721$3**5<:2=92935;+<=:96%:8;;<;<5:1:49887:9&22.39668>7;>=;4598)997+('-088)33:;7:69=;;>3<6?;:;7<>5:806;;967:.=01<;9947:99:93:98==95:=96&8<82=4;5>>?;:8477861,56?>>;89.7<5;99-.**6.>>===:418=4/<;>>?<628=8<:777;'>18028>72+>:>>::4734;:7<25<:860<7473==:9::->?>;;9>43:8;/5191;$37=26768;;1/;6/4:44735&5.112/%552942/12$04&1'4/4/4;4:75%16.-5839992167.,55572:220933*5809677:/275694945576084:9::27110'16/;27397.'01539--,2+979713.5*1:219655681-345:.0.6/2743582/2059543941-2:5617'49/547-.729345+.9.*(*,37353:93:5,5633'555:956971;8:/60-8,47/84954303)368::2327786&95:7:::725-86:722%86553547/68::8:66199:51064'6.323431765%/*3219:39897-06959949:8+7/97794663035635;;63;698(4)199;5247.:956.395653,+507:/7:8431752+3978879309/1871/220$6.3+,&2.954-/96,*7'9:787:74-.55.4562--.7&98/12&2:1.)'321.-.78/1.7:9277:;7:84*3%+/**-246453/./-.#25587/656:26463/831590,/+9:59/584344%947:0687/)5'9:921768802+%-82&35),-::255138'16497701'9:20055486:32$1527-57043'3+4-5978;33(-1-52.*5320(862:8676777250,/4/5$0--4:1+:266478758763203(3/76:6:77706,3,..1/,3'35/03935:60/3*/030%651066037*471+,6935833/594706/621726892*177-516/&,5843,:22.5./2/63435698442035-&)//-,*5754)/1+.2*95:450*2/:++0%85:163523/(816403612.+417868556'2144-40564544-116/$*$-,/34;448/1/665.4264/5465-1.45216+,3'86721/44288:5-310/976:68418/..535/636679.2285878:8512,2.45,./&30-22+,%04656.764344526,-/+63*/53447-84(-30)+,4/1+03/.12/:5745838/169746406-90.2("487/200/+358:8677464869.5-274098877/15*-441)50/11./1.)4405.+1&37733/3010/(976+7/.,8-64742.8305186-5+369597357/667,6648/476/4..*(/+16*4442954/2.51024(.06)+/-030*/(+,/4+250344+*132,&,(0&)*,(&&#'.*02*1+40/334/.1033&*0/0*0,2..0/11-.1-+%',-&1321.*1,/-0&2-2/+01,).&,..-/21510)21/1+..30,+/*,*)&/0+1.4-5&,/..&)%%-%,,/,.02%),*4,*.0001(-//*0*/$(11)'%.3-&0-..,312+/-210-%..(/%.1)-/0*(*0'2335/.-+,)-.+,&0++**,-&..'.(),)*,,--,&(./(.--/)'(*).-''(++')(*,)*$'(,+)*&)&%#,%*,+-)$+**$(,-(&()(')'+(',*(*)"'#'-,(#,*),-+--(--)++(-'*(%&#,+(**%(),''#)&),-**))'',''" @rCer/323/2812_61_CCS ATGGGGAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGTGAGCAGCACTACGGCCTCCTCTCCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCCGCCTGCTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTGCCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTGCGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGGAATTTCGATGGCTCTAGTACTTTACAGTCTGAAGGTTCCAACAGTGACATGTATCTCGTGCCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCGAACAAGCTGGTGTTGTGTGAAGTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATAATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAATATACCCTCATGGGGACAGATGGGCACCCCTTTGGTGGCCTTCCAACGGCTTCCCGGGGCCCCAGGGTCCATATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTACCGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCCCAGTGGGAATTTCAAATTGGACCTTGTGAAGGAATCAGCATGGGGAGATCATCTCTGGGTGGCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCTAAACCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGGCACCAGTACCACATCCGCGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGCCTAACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAGGGTTACTTTGAAGACCGTCGCCCTCTGCCAACTGTGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTTCTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCTGTCAAGCCCCTCCTAGTTCTTCATCCCACTGCAACTCTTACCCCTCTCCCAGTTGTCCCAATTGTAACTCAAAGGGTGGAATATTAAGGTCGTTTTTCTCATTCCTTGTGCCCAGTTAATCTTGCTTTCTTTGTGTGGCTGGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACCTACCCTCCTTTTTTTCCCTATCACTGAAGCTTTTTAGTGCATTAGTGGGGAAGAGGGTGGGGAAACATAACCACTGCTTCCATTTAATGGGGTGCACCTGTCCAATAGGCATAGCTATCCGGACAGAACACGTTGCAGGAGGGGGACTTTTCTTCGAGGTAGCTGAAAGGGAAGACCTGACTTCCTCTGGTTAGGTTAGGACTTGCCCTTGTGGTGGAAACTTTTCTTAAGAAGTTATAACCAACTTTTCTATTAAAAGTGGGAATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTTGGTCTCTTGCTTGTGGGACTAGCCTGGCTTGGGACTAAATGCCCTGCTCTGAACACGAAGCTCAGCATAAACTGATGGATATCCCTACTTGAAAGAAGAAAAGGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTATATTTAAATGTAAAGACAAAAAATTATATGTATGGTTTTGTGGATTATGTGTGTTTTGCTAAAGGAAAAAACCATCCAGGTCACGGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGAGTGAGGGAGGTGGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATTACCACTTCTGGGTTTCTGCCCTGCCCACCCTCTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTAGCAGTCACTTGATCTCTGTGGCTTTGGTTTTAAAAGACAGACACTTGTCCACATGGGTTTAGAGATAAGAGTTGGCTGGTCAACTTGAGCATGTTACTGACAGAGGGGGTATTGGGGTTATTTTCTGGTAGGAACAGCATGTCACTAAAGCAGGCCTTTTGATATTAAATTTTTAAAAAGCAAAATTATAGAAGTTTAGATTTTAATCAAATTTATAGGGTTTCTAGGTAATTTTTACAGAATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGGACAGGGCTGGAGTCAAAACACTTGTAATTTGTATCCTGATGTCTTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTATAATAAGAAATAAACCCCACCTTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAAGTCAAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCCAAAGGAGCACTTATAAATCAAACCT 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rCer/325/25_2032_CCS ATGGGGGGACCTGCTCGAGGAATGGCGCCGCCGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATCATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACAAGCATGACGTGGAGAGACTGAAAGCCTCGCTGGATCGCCCTTTCACAAATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGTGCCCAGGTGCAGATGCAAAGAAAGCATGTACCTACATCAGATCTAACCTTGATCCCAGCAATGTGGATTCCCTCTTCTACGCCGCCCAGCCAGCCAGGCCCTCTCAGGATGTGAGATCTCTATTTCAAATGAGACCAAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTAACCAGATCTACCATGCAGTTGCAGCTCTAAGCGGCTTTGGCCTTCCTTTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACGGTCCAGGCTCTGCAGACAGCATCCACCTGTCCCAGCAGGCTGACCTGAGAGCATCGTGGAGGAGATTGAGGACCTTGTGCTCGTCTGGATGAACTGGGGGCGTGTATCCAGTTGAAGAAGGACTGGAAACAACAGCGTATTTGTGGCTGCCACTACAAGCTCATGGATCATGTGGGACTGAGCCATCCATTAAGGAGGATCAGTCATCCAGCTGATGAACGCAATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCTCTGCGGCTGCTGTACTTTCCCATAATCGCTACCACGTGCCGGTTGTGGTTGTGCCCGAGGCTCTGCTTCCGACACTCACGAACAGGCTATCCTGAGTTGCAAGTCACCAATGTTTTGTCTCAGCCTCTGACTCAGCCACTGTTAAACTAGAACATGCTAAATCCGTTGCTTCCAGAGCCACTGTCCTCCAGAAGACATCCTTCACCCCTATAGGGATGTTTTTGAACTAAACTTCATGAACGTCAAATTTTCCAGTGTATTATGACTTCCTTGTCAAAGTTGAAGGTGACAACCGTTACATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGCATCACAAATGTTGATCTTTCCACTGTGGATAAGATCAGAGCATTGCACCCAAAACTACCCGGGTGACGTACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTTGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTCGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATCGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCTACTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGGCCTGAGAAGAGGCCCCCACCGTGGTGTCCAATACATTCACTGCCCCGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTCGCTCCTAGCACGATTATATTTCACCTGGACATGCTGCTATGCTGGGCTCATGTATGTTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACTGGCATCTTGGCAGTGTGACGTTTCTGGCTGGCAATCGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAGGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAAAAGAAT + 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@rCer/326/0_2627_CCS GGCTGGGACGGCGCTCCGGGTCCGCGGTTTCAACATCGGAACAAACAGCGGCTGGTCTGGAAGGAACCTGAACTGCGAGCGGCGCGCAACGGCGGCGGCGGCTAAGCACCTAATCGGGAGCCTGCAAGTGAACAGCTTTGAGTCTTAGACAGCTGGCCTGGAGGAGAACACATGAAAGAAAGAACTCAAAGGCTTTGTTTTTCTGTGAACAGTATTTTCTATACAGTTGCTCCAATGACAGAGTTCCTGCACCGTTGTCCTACTTCCAGAAGCACAGATTCCGAGACAACCACTTGAGCAATACTATGACAATAGAGAACGCAGAGCACAACGACAGCGAGCCTTGGCCACCTGAGCCATTATCTAAATGACGACCCCAGGGTAACTCTCGGCAGGTGTGGAGCAAGATGAAGAGAAGATGAGGAGCTGACATTGAAATATGGCGCCAACATGTGATCATGCTCTTTGCCCTGTGACTCTCTGCATGGTGGTGGTCGTGGTACCATCAGTCAGTCAGCTTTTATACGGAAGGATGGGCAGCTAATCTATACCCCATTCACAGAAGATACCGAGACTGTGGGCCAGAGAGCCCTGCACTCAATTTGAATGCGGCCATCATGATCAGTGTCATTGTTGTCATGACTATCCTCCTGGTGGTCTGTATAAATACAGGTGCTATAGGTCATCCTGCCTGGCTTTATTAATCATCTCTATTGTGCTGTTCTTTTTTCATTCATTTACTTGGGAAGTGTTTAAACTATAACGTTGCTGTGACTACATTACTGTTGCACTCCTGATCTGAATTTGGTGTGGTGGGAATGATTTTCCATTCACTGGAAAGGTCACTTCGACTCCAGCAGCATATTCATTATGATAGTGCCCTCATGCCCTGTGTTTATCAAGTACCTCCTGAATGGACTGCGTGGCTCATCTTGGCTGGATTTCAGTATATGATTTAGTGCTGTTTTGTGTCGAAGGTCCACTTCGTATGCTGGTTGAGACAGTCAGAAGAAATGAACACTTTTCCAGCTCTCATTTACTCTCAACATGTGTGGTTGGTGATATGCAGAGGAGACCCGAAGCTCAAAGGAGAGTATCCAATTCAAGTTAGATGCAGAAAGCACAGAAAAGGAGTCACAAGACACGTTGCAGAGAATGATGATGGCGGCTCAGTGAGGAATGGGAAGCCCAGAGGGACAGTCATCTAGGCCTCATCGCTCTACAACCTGAGTCACGAGCTGCTGTCAGGAACTTTCCAGCAGCATCCTTGCTGGTGAAGATCCGAAGAAAGGGGAGTAAAACTTGGATTGGGAGATTTCATTTTCTACAGTGTTCTGGTTGGTAAAGCCTCAGCACAGCCGAGTGAGACTGGACACAACCATAGCCTGTTTTGTAGCCATATTAATTGGTTTGTGCCTTACATTATTACTCCTCGCCATTTCAGAAGCATTGCCAGCTCTTCCAATCTCCATCCCTTTGGGCTTGTTTTCTACTTTGCCACAGATTATCTTGTACAGCTTTTTGACCAATTAGCATTCCATCAATTTTATATCTAGCATATTTGCCGTTAGAATCCCATGGATGTTTCTCCTTTGACTAAACAAATTGGGAGGACAAAGGTGATTTTCCTGTGTCCACATCTAACAAAGTCAGTTCCTGGCTGACTTCTACAGCTTCCTTCCAAGTCTTCCTGACCACCTGCAACTATGGACTTTGAAGGAGGTGCTATAGAAAACGATTTTGAACATACTTCATCGCAGTGGACTATGTCCCTCGGTGCAGAAACTACAGATTTGAGGACGGGTCAAGGAGACATGATGGGCCCGGAAGTTGCTGTGCCCGTCAGCAGCTTGATGCTTGGTCACAGGATGATTCGCGACACTGCGGACTCTCAGGACTACCGTTACCAAGAGTTAGGTGAAGTGGTTTAAACCAAACGGAACTCTTCATCTTAAACTACACGTTGAAAATCATCCCAATAATTCTGTATTAACTGAATTCTGAACTTTTCAGGAGGTACTGTGAGAAGAGCAGGCACCAGCAGCAGAATGGAGAGGTGGCAGGGGCTCCAGCTTCCCTTTGATTTTTTGCTGCAGACTCATCCTTTTAAATGAGACTTGTTTCCCCCGTCTTTGATCAGGTCAATATGTGTAGATTGACTTTGGCAATTCTTCTCAAGCACTGACACTCATTACATCTGTGATTGTCATTTTTCCCAAGGCCAGTCTGAACGTGAGGTTGCTTTATCCTAAAACTTTTAACCTCAGGTTCCAAATTCAGTAAATTTTGGAAATAATACAACTATTCTCATCAATTCTCTATCATCTTGAAGTCAAATTTGGATTTTCCCACCAAATTCTGAATTTGTAGACATTACTTGTAGGCTCACTTGCCCCAGATGCCTCCTCTGTCCTCATTCTTCTCTCACCCCACACAAGCCGTCCTTTTCTACAGTCAGTAAGGCAGCTCTTGTCGTGGTAGCAGATGGTCCATCTATTCTAGGGTTTTACTCTTGTGTATGATGAAAGATGTGTTATGAATTGGTGCTGTCAGCCCTTGCTGTCGACCTTTTCCACAGCAATGGTGTATGCCAAAGACAGTAGATTAAAGAAGAGTAAATGGCTGTG + S!#$##%%$#%$""#$$"$$#$%%$!"$%%$$%#"&($$$(%$'&$##%')$%$&&%&$&$(')(.-)'%$'(+--*))+&*$#%#'(++*+-+*--.-*)+%'++')+)'%(*)"*+)()+---+*,($#)*(%#$,-(&$($&(-),,,*+',-&,*&,'(-&)(,''%+)--,.,(,%'&&#%&#$#&%)%+*$#***++)-,*$)+&&$*$'&)+&%(%)*,+-+,(&+')&)*(++)%###,*,((+.('*)%&)(++'*,,()#&$(-,**-('&&%&%'(()+-,,*,('%'%()*''&()&+*)--*&%&,('%*#$((%&%'*%*$&&'#((&''*',(,'#*)(&('+)*++*-*#)*+#&(*,%+*+''(*&+,*)*+*')**&)'#'()$(*))(&*+(,)$&'(%('))&*,,(+*,',+))(+*)&%%+(+*%#+(*())((+)(($')(&((""(***+--,*(')-++)+--*)*'#''(-+%$#((-,)(#),&'(+)),%%+,*##&$%''*+,'&**.),,')()&))%*%$(&&*+-'&)(+)-*+'+)++&%(),,&&--'(+-,+(,(+*+)+*+++($$"#),-*''*,+-*,$'**)&)''()(+%$*%&(*)$%+#%,-,+'*,,)+''%'*#%)+,)*%)'(&%'$''((%&&($()'%)((#(%,+'*"&*(),*&#')%*),)'$'(*#&*%&%*&&---,,#$'*,-+*-+((&%*)#%())%)%"$##(-,,-(('*+,**)+'+-,(%&+'+)(%++&%)((*+'((%%$*+$'+%,(*''+(&**%''*+()**(-+)+,(&(('&,++-*$(*(,+)))(''(&*&$&((,%$')),(++%$(***%+*-,)$&#%))#((&*+('%$'*)($'($()('--)-+'+))))%+&'*+(%$*+,-,&#+++-+',+)(,,#&$'((')#((*),+++-+*#*%-()('())),*+,'('')*-(,)((,+-(#%&$"$)()--*#+&&%$,,,#**,',#(,,+-,((%%'*#%$"%""'*%&'-)++,%&)+#$#&$&(')*#'$%"'+$,,%,,(,(+%'+,%###*)+%(,+($$#&)*(+'&,*)(((')$)*$#''*+&%&+-*)+((#),-*'+)+)'$)(+)'%&),'+&$)$**,(),%)((--,,*&())'%',---,)))%')$)$,+,),''+)*('""&%&&)+-)--+%(*&),&*$),)$''-(-,))*(%&(+*,''*#$&,(&&(-,++,,',)'#+.,&)(''+*-*)'++***,--(+-*)*'''*--)*%)*,+&)(+--,#+"$'*)+++%$),,(***%,%#&(*%'%$&)#%(')%($#&)'&+&**()$#&'&),--%()('('&&&'*-&*(+*..--+'),*,))*.'&+'+(%,))++-%$*)%#'$,*,++*+,-('$%').)%&$%$'%'*''%)#))'*(*&,*(,..+,'%**.,'*$'#+%)-(+)#*)$%'&%%&)-,$#&&*%'**'(&')+'*&*-,-+,-,())+,*+((,,((*-+*-*&*%&(-,'-+)-*-(%&&,*')''#,+'(&#$"'##(('#&,+()),*)-,(,,,+$(+)((*,*--(-&%%)+(&*'%'')++$($)')'%&)'$"$&,*(*&'''(-*-(*&)%'((((+*,,')),(##%**%*'&&$%''($*&%%)())&))&#$%&$%$(+''()&(),&&)&')))$))%',-,),%+*$++,(*)(-+,,).-*+'()-*)(&"%&%$)''$',*'$$*),&+%-)+&%',(+,+,+%*)'((&$%,+-+-+)#'+-.)/)%(++*,0/-/102%,)+'$%$'%0-.)$,*$$&(''&(./2)0,.01.12+*)%+1,+10,.*0*)$*..-00----.)/,0-%-0)0+/-'&)(-'*))/+,,+.1*-,,+/*0/&*/)*001-0-/*1,'*,-0)-),0-0%,*/.*,)-*110/-1.),-0-/-.1/0,*/&,-++''1-,111*++/&'&-*%*-+/&-*%)++/+1-%+%&&,///,00.(,&+%,('0./0)0/.//-.0.-/+0'//%'$*%--/*).%+110-+.+(0.(./--.+(#'*+'%.1-,-/*1#+(00,0(,,)10&'%-+(...0021-/,),)0//'+/)1-1.0),/.)$)+011-.,$*,/1.,1&%/$'-#&'2--/..*0)%0&+%,,*1-.0.),+%+-./'/0-+%-./00+-10/12,/,/.0//21-11-.1%-*,++&...&-**/)/,(*$**1--/1'../,*/.(.1,++/0--/100%./$+.%+)(.,,#*+)%(&.,%,/11*/)-/()-)+*/%--.)./*%-0-/,-,%-.&.+/...+,,-,--1/*-))0.11-,.*,.,+/-+"$$%(-*-+-,+1,*%''0/.&)'+*-.0'/-,0.21+0***"!&&$&"#&(''++'%+)+(&)*+%(%$)##$%+($((%$$#$$%$$"####$##"#$#""$#$%%$$#$%"$$%%%$$%%%%%$%%$$#$"#%#"##$$%"%$%$%$"#"$##!"%$#$$"%$%%#$""$#$$##%"#$$####%$$%%$%%$$#"# @rCer/327/24_2229_CCS ATGGGGAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGGTGAGCAGCACTACGGCCTCCTCTCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCGCCTGTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAATAAAGACATCGTTGGAGGCCATTACCGGGCCTGCTTGTAGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGTCATGCCTGCCAGTGGGAATTTCAAATTGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTGGCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTATAGCAACTTTGATCCTAAACCCATTCCTGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGAGGAGAATGGTCTGAGTACATCGAGAGGCCATGAGAAACTAAGCAAGCGGCACCAGTACCACATCGCGCTATGATCCCAAGGGAGGCCTGGACAATGCCGACGCCTAACTGGATTCCATGAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGACCGTCGCCCCTCTGCCAACTGGACCCTTTTCGGTGACAGAAGCCTCATCGCACGTGTCTTCTCAATGAAACCGCGATGAGCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCGTCAAGCCCTCCTAGTTCTTCATCCCACTGCAACTCTTACCCTCTCCCAGTTGTCCCATTGTAACTCAAAGGTGGAATATTAAGGTCGTTTTTTCATTCCTGTGCCCAGTTATCTGCTTTCTTTGTGTGGCTGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACTACCCTCTTTTTTTCCTATCACTGAAGCTTTTAGTGCATTAGTGGGGAAGAGGTGGGGAAACATAACCACTGCTTCCATTTAATGGGTGCACCTGTCCAATAGGCATAGCTATCGGACAGAACACGTTTGCAGGAGGGGACTTTTCTTCGAGGTAGCTGAAAGGGGAAGACTGACTTCCTCTGGTTAGGTTAGGACTTGCCCTTGTGGTGGAAACTTTCTTAAGAAGTTTAAACAACTTTTCTATTAAAAGTGGATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTGGTCTCTTGCTTGTGGGACTAGCCTGCTTGGGACTAAATGCCTGCTCTGACACGAAGCTCAGCATAAACTGAATGATATCCTACCTTGAAAGAAGAAAAGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTTATTTAATGTAAAGACAAAAATTATATGTATGTTTTTGTGGATTATGTGTGTTTGCTAAAGGAAAAACCATCCAGGTCACGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGATGAGGGAGGTGGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATGACACTTCTGGGTTCTGCCCTGCCCACCCTTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTACAGTCACTTGATCTCTGTGGCTTTGGTTTAAAAGACAGACACTTGTCACAATGGGTTTTAGAGATAAGAGTTGGCTGGTCAACTGAGCATGTTATGACAGAGGGGTATTGGGTTATTTTCTGTAGGAACAGCATGTCACTAAGCAGGCCTTTGATATTAAATTTTTTAAAAAGCAAAATTATAGAAGTTAGATTTTAATCAAATTTATAGGGTTCTAGGTAATTTTTACAGATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGACAGGGCTGGAGTCAAAACACTTGTAATTTTGTATCCTGATGTCTTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTTATAATAAGAAATAAACCCCACCTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAGTCAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCCAAGGACATTATAAATCAACCTAACATAAGATCTCTCT 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rCer/330/2584_54_CCS ATGGGAACACACCACTGCTCAAAGATGACAAAGACAGAAAAGCCGAAGGGAAAGTAGAGAGAGTGCCAAAGTCTCCGGAACACAGTGCTGAGCCGATTAGAACCTTCATTAAAGCCAAAGAGTATTTATCGGATGCCCTCCTTGACAAAAAGGATTCATTGGATTCAGGAGTGAGGTCCAATGAGAGTTCTCCCAATCACTCTCTGCACAATGAAGTGGCGGATGACTCCCAGCTTGAAAAGGCAAATCTCATAGAGCTGGAAGATGACAGTCACAGCGGAAGCGAGGAATCCCACATAGCTTGAGTGGCCTGCAAGATCCAATTATAGCTCGGATGTCCATTTGTTCAGAAGACAAGAAAAGCCCTTCCGAATGCAGCCTGATAGCCAGCAGCCTGAAGAAAACTGGCCTGCGTGCCAGAAGCCTACAACCTGAACCGAACGCCCAGCACTGTGACTCTGAACAACAACAGTGCTCCAGCCAATAGAGCCAATCAAAATTTTGATGAGATGGAGGGAATTAGGGAGACTTCTCAAGTCATTTTGAGGCCTAGTTCCAGTCCAACCCAACCACTATTCAGAATGAGAATCTAAAAGGCATGACACATAAGCGAAGCCAACGTTCAAGTTACACAAGGCTCTCCAAAGATCCTTCGGAGCTCCATGCAGCAGCCTCTTCTGAGAGCACAGGCTTTGGAGAAGAAAGAGAAAGCATTCTTTGAGAAAAACAAGCAAAGGAGAAGAGTATTACTGTACCCTTATGACAGAATTGTCCTGGATTTGACTCCATCCACGCCCATCACCTTTCTACATTTCGCTGACAGATCAGTAACAGATGATGAGGCGAGGTAGAAGAGACATCCGCAGTGTGACAGAGGGAGCGCGAGAAGCATGACTCATCAGCCAGCCTCTATTGTCTTTGTAATTAGAAGCTTCAGAACTCACTAATACCACTGTACCTTTCATTGGCGCATTACCCCATAAAACTTTTTGAGATGAGGTGAGATCTGGGTATAAAGATAGGCCAGAAGTATTTTAAAGGGCTTAATTTGCCAAAAAGAAAAGTAAAAAGCTAGAGACCCTTTTTGCAGAACATTTGGTGCCCACACATTTGAGGGAAGATGTGGCTTTAGATGAAGCAGAAGCAAACCCTGCTCTTAGGGTCTCGTCTAGATGAGTGCACAGCCTATGACACTACAGGGAGAGGTCAGGAAACTGAGATCCAGCCTTCTGGGTGACACGGGCATTGTTTATCACAGAGGTTCTGAAGTTTAAGTAGCAAGTACATAATGAAGAGGGCTTTAAAAATTGCTGAGAAAGCGAGTCACCAGGGCTGGCAGTAGTGTAACGGGCTGTCCTGAGCGGTTAGGAGAGTAGATGCTGGGAGGGCTGGTGACCTCCATGGGTTTATCTGTTGGAGACTCTTCTCTCCAAATCCCAGGCCTGGCTTCCAGCACCATCCAGCTGTGCCCAAGAAGCCACCCTGGTCCGTTCTCCAACTCTTTTAAATGGTGCCCAACTTTTCTAAGTGAGCTTAGCAATGAGAAGAAAAAAAAAACATGAATTCTTTATCTGGAAAATCAGGGAAACATGGGTAATAATAGGCACTAATAAATATTATAGATGAGTGAATGAGGAAATAATTACATCAGAAAGGTCAGTGACAATTGATAAATGACAAGGAAATATTAATTAGGTAAAACTAAATCATTGCTCTGTATTCTAGGATAGACTTTATCTACTTCGTCTGTTCCTAAGTCAGCATGTTAATTCTGGGGGAGGATCATAAGAAAGGAAATACTTTTTAAAAAGAGTCTAAAAACATGTAACAAAGCAAGGATAAAATTATATATATATATACACACACATATATAATATGTGGTGTGACTGTAAAACTGTACTTTCCATTAATTATTAGCGGAGTTAAGAGAATGATCACATTGAAGTACTGTGTGGACTAGAAATGTGCCCTGTCATCATGCAATGAAATGTTATCGTTTAAACATAGCTCATTTATGTAGAATGAATTCTGGCGGTTTACCCCACGTCACAGTTAGGACAGTAGATGGTGAGATCGCAGATGCACAATTATCTAGATTCCGTGTTACATTTCAGTGTTTATCACTCAGTGGATTTTATTAATATGCTGATTAAGTTATTTACTTGGCCAGTCATTGTGCTAAATAGTTGCTCTTTTGTGTTTCATTGCCGTGATGTTTGAGTGTAATCTAGCATTTTAATACAGTGTTTATTTTGCATGATCTTTAACAAACGTGTTAAGCAATTTTAAAAAGGCAGGATGTTGTTGACATTATACACTGAGTCTTAACATTTAATATTTATAGTGCTTATTAGTTTGCAAAGTTGTATACTTAGGAATTATTTCAGAGACAATGTTTTCTTTTTCAGGTGAGTAGTTGCCGCGTAATATCATTGGATACATTCTTTATACTGTTTGTGAAATTAATACTAGCATATTAAGTGTATAAATAGATTTAGAAAACAATAAAAAATTGCATGCTATTCTGACT + ADED,I@HJF?JAGG?CH;IIH9EIH?FHEB.HFHDGIHK5>GGHJEKK<>H+I:EGFFH=:CHHDEIK@D>FEB>E@>D@A@D><7EGFHEJ:IHB8B8I5JEF>>HC@KKCBEG9JECD,IHFGGHC'K?EJGGIGHJE?IAIAB4>.JHIH9HK8JBJHDCA9B/?HHI:K:IGEIIJKH=HAFFH=C?JJFCHDF>7BC1:HJJHEHII1FAHC@6A:I@ADHID:D2FEDC@,C5HJ?6A7GIJHCHGJI?HJFGH@FAD=DC8EGGD;@=GGFHKKH6DHK>KIJCJHJK6HKHDHF-CDJFFGF>6DGK0E33GHHGJKC@ED-DG=@GJJCFFKIHDJCA?HJ@AKDE@0AEIJFGC@9BCJGI;@>DHGFGJGHIGEHBD@C>IJBEFECA83.DIKKEJCIJ=A+41ED;GAKEJJAGG*I@>B>KJJ5;K:I;KJK@FD7:C;DE>FJ>F4IHG;KHH;C5AG>H:GF?%C7:DCIGFCE1F?IBI@FF9?EE$GCHI;:?>@8>=@@:,A=DDA9DJEE1FHJDJHH8B:DIFFKECBAA26AEEBFEKGJ=CFBC>CFKDEFBA,:AHDGJDGKDB9IJJKFJIGIJCGK>FJH5FIJEKFKKKKD/HGIBFIKGK=GGKFJJKKDHHJJECF1E9K5DJJGBJ=JKJ>,@FKJ6IEKKB=+AHHJIAHGHHBBCGG9DJGCJ1BBIJ7G>AJJKKDGIKKEJJKKGJJ<>KKH@AJKJ9EKIKJHGDKFIGIFGEJK0IBJDKIK7FGJJKKKFKDJ8E4KKEKKKEEBJKFKHB2DH=DGEB7JKK6CFKJ*HKKIHGFE%K;K;IKKHKJJK8KIK9GJG@DFKIEJDJAEFJ>KJJKJKJKKA6C(==AIE8D,GKI3?AA?J3GGA'IJ@E@&FK+H?BAG0IJ@-JFICB1HIFIKAG>:*F1G$C77FGJIH8D;D?JKBB>@<:IBGD@I8FJ?HH>FE,;=J>BAD5F;DG-;KAF?FJFFHHDHHJ>GJ)G4H?F)DIIE(>IC=JJDFI;:H=3E>BH3HGJJJJ=(BFKH2D@=CCGFCAA.><6>CH;@C?%IFD&J5FF79=.-5*1$2(($75.63*0@DDFE><@3/DA(.AB925?/;@6:FH;A8HHE=B@C?@BFC@C8EF,KAKDGJHGHIH,;KBEGH>@GFEBFG97G8=E3JEFBDA::;AC'C>FGA@GFHEB*C9HDG5GI;GG3CEFE'JKDGIDHHDJ;BI8HIIKEEEFIH(BC:FFHJHEFE@<HEKCHBGFGK=HCEDC/IGBC@IHCHAJ=IG=FFHI36<6;8?<)BCGFG1A:D=GF=FEGCHDHF7@==H=8D7?D@/CEFBHI4A@C?D8G;ED?0?>690@@=;1=:BBC:DCHBB0=<7E?7DCAEJ4FG;%CBB:/BF<=?GI$$%C5=A-9@:>==AE3FFC8HHE7AAAD.C?79?6>?FH>J;D>AJACD=EED*BH=DEGFJ:BDFDC,CFG3=?8DEABG8AF?GCCBICD5:@>HBEIGECIFDCHHG;@9CIECI?/<-6<<'A:>)@EI?>>E9ACJGH8AFFA>BFJ?EGDGJF?E@HIH3EGAEB??BB%E1EFEAC9DBH<>GGC@8 @rCer/332/0_730_CCS AGGGACCTTGCTACTAGAGATCGTGACTTCCTCCGGGAGCCACAGTCATAGAATCCCGGCCAGCACGTCCCTATGCACCAAAGGCAACCAGTGGTGTGATACGACGACCAGGAAAGCGTCAAAGCAGGTGCAGTACCTGAAGGACAGGCAGCTGGCAGCGCCATGGTATGGGCCTGGACCTGGATGACTTCCAGGCTCCTTCTGTGGCCAGGATCTGCGCTTCCCTCTTACAATGCCATCAAGGATGCCTCGCCGCAACTTAGCCCTCTGTTCTTCTGCACACAGCACGGGGCCAAGATGCCCATCCCTCTGGCTCCAGTGCCAGAGCTGATCACTGCCTGCTGAGTCCAGTTGAGCCTCAGTCTCCCTCCTGGAGCCTATGCAGAGGGCCACAACACACAGATTGAGCTCAGCCTGGTGGCAGGGAGTAGGATGGGCTGCGGGGATAGTGAGGCATACAATGTAGACTCAGGATTAGTATACACTGTTGATTAATGGAATATTTACAGATCCCAAGCCTGGCAAGGGAATTCTTAACTCCCTGCCCCCAGTTCTTACAAAGACACCATTTGGCAAGCTCTATCACCAAGTAGCCAAACATCCTACAAACACAGTGACCATACTAATTATACCCTCTGCAAAGCCAGTTGAAATCTTCACTTAGGAACGTAATCGTGTCCCTATCCTACTTCCCCTTCCTAATCCACAGCTGCTCATAAAGTACAAGAGC + S(((##%#&'$#('$&###'($#%'(%((%'$&##%'((()()'(*$$'',(,(+(#$(+-'&&%#**$00+)/-*,'+$&*+0*-/120'+-0$%$%.-*0,)-/0,0.,1'*(,+,,/%,*)+('+*-.)+*/+,,0.*%),10,+*.-'0.2++)-+0/0''/+++*(()/3-54%*.)*$155.*0$0/-5+-120244(3'0'--&/.(./+0.#)/+4/))(,-)&,011653510+0*,-$110++.5)*1,(,),)0/./+//42&11,-(,/45/10141656).('$2..'044&$2220*-42(2580#''*-&2,,,,/21)$,.&707679.%4.77()74:53:*461/(,&4)+*.$(*40.69.-.:792'99&5304:-44++345$2#-/4351')6005*)4,.'34/$+,')*$,313'04%02423/859:.4453&45:-1*$+.3559'52-50652-+-02(65:5:89/38,,'7$4$)-/)3+.0&612:8294+92,8&7217-73,1$8(/,7115%0)/3*&+7/-3,#-8.'260.1&'38(64+9.64156952&//97-1%)8%57/.1$737:&*$0550,,2-2:-/10&34'0/,-(2332498-785&76.%63*461&*7124.3417+6*553:55',-0+:935,55::6+9#2551:(51)+(+54614&185-+(.%33228675,--3 @rCer/333/25_1932_CCS ATGGGGGAGAGCGGCGCCGGCCTCGGAGGCTGAGGAAAGCAGGAGGAGGTGGTGGCGGCGGGAAGATGCTGCTCTTTGGCGTAATTGCAATCGATTAGGATCGTTTCTCAAAATCAAGTTAGAAGTGAGAGTTCAGATAAGTGAGGCCGCCATTGCTGCTTTGACACCTCAGAAGGGGAGAATGGATTATCAGGAGTGAAAAGAAGAGCTGCTAGGAGTCAAAGAAAATATAAAAGTCCAGCACTAGGGCTCCTTCACCCACCAAACGCAAGGACCGCTCAGATGAGAAGTCCAAGGATCGCTCAAAAGATAAAGGGGCACCAAGGAGTCAAGTGAGAAGGATCGCGGCAGGGACAAACCCGAAAGAGGCGCAGTGCTTCCAGTGGTAGCAGCAGTACCAGATCTCGGTCCAGCTCGACTTCCAGCTCAGGCTCCAGCACCAGCACTGGCTCAAGCAGTGGCTCCAGCTCTTCCTCAGCATCCAGCCGCTCAGGAAGCTCCAGCACCTCCCGCAGCTCCAGCTCCAGCAGCTCTTCCGGCTCTCCAAGTCCTTCTCGGCGCAGACACGACAACAGGAGGCGCTCCCGCTCCAAATCCAAACCACCTAAAAGAGATGAAAAGGAGAGGAAAGGCGGAGCCATCTCCTAAGCCACAAAGTGCATATTGGGAGACTCACAGGAATGTGACAAGGATCACATCATGGAGATATTTTCCACCTATGGGAAAATTAAATGATTGACATGCCCGTGGAAAGGATGCATCCCCATCTGTCCAAGGCTATGCATACGTAGAGTTTGAGAATCCAGATGAAGCTGAGAAGGCGCTGAAGCACATGGATGGAGGACAAATCGATGGCCAGGAGATCACTGCCACTGCCGTGCTGGCCCCTGGCCTAGGCCACCACCCAGGAGATTTAGCCCTCCAGGAGAATGTTGCCACCACCGCCCATGTGGCGCAGGTCTCCGCCACGGATGAGGAGAAGGTCCCGCTCTCCGAGGCGCAGGTCCCCTGTGCGCCGGAGATCACGCTCCCCGGGACGCCGCCGCCACAGGAGCGCTCCAGCTCCAACTCCTCCCGATAAACAGGCCACTGAAGCTCTCGCCCCTGTAACTTATACCCCACCCAGCTCAGTTTGTCACTTTCTAGCCAAGGAAGATCAGTAGGAAAGCAAACCCTTCACTCGGGCAGAATTGCAGGCAGCAGTCAGCACCCCTCTGCCGGCCGGGCTCTGGCTGCAGAAGTGCTGTTGGTTTGGGTGTTGTGTGCCTGTCAAGATTCCCTCGGTTTTGTGGCTAGGAAGCTCGCCCGCTTCCAGTTCTAAGAGTCAGTTCAGTGGCAGGGCCACCAGGGACAGGTGAGGCTCTGGGGATGGTGTGACCCTGCCTGCCTGGGAGCACACTTTTCCCTTCCCTAGTTACCTGAGATGGTTGCCAGACTGTGCCCTTGCTGTTGCTGGGCGGTGTCCTTTTGGAAAGGGAGCCGTCCCGAGCTTTAGTGCAGCTGCCAACCCTGTTAGCCTCGGCCTCTTGAGGCCTCTTCCAACTTCAAGGGTCACACCCCCAAAGATCCTCTCACCTATGGTAATTGCTGTGCATGGTTCTGTCTGTCCGTGCACCCATGCACACACCCCACCCACCACCCTACTCTGAAATTGGCGAGTGAGAGCCAGCTGTGCGGGATCATCATGCAGCCATGGTTGTGCCTGCCCTTCGTGGTGGTCTTTCAGGTTATCTTGGCAACATGTACATTGCTTTTTTTTTTTTTTTTTGCTTTTTTGCTTTATTGTACAGTCAGTACTATAAAATTTCTCTTGAGTTTTATACCTTTGTAGCATTTTAGATGACATTGTGTTTGTACTTTGTTGTGTAGAGTGGAAGAATTGTGTTGAATAAACCCAAGATGGAATG + =?%@?@981,9B:C5:&:=9A14>7&=57C5(<:-@;&<<0C>:?>;3?=AB/D?9;?:5$9.2C@.C/;BB?=:#C6:F@2A=575*CB;<=8?(<;6C@7B@7<8D;B?7#3>.39@;5=4=??:9=&:;<<&=;:3<$;EE94>9=;A*CB<&134,%3+9=>;<>E8ABA>:C9AD9<1C4G159ECA:A+FBB6FA+FC+EE/)9?@)@6D+0;A,683:B=?GA51A949%AD-BF@)B<=@;BECE?<@EE2>-?:<7/>>4B=72649993C9@?;;7A*80<@;A@=CE1/+ACGB?>A@>:><@DB?C@?3C-7?;>.)E?BE@A2?5@@?A92>E@CB;A@E5E9=5EF8BDG@>)?DA>EA7C,<=BB3A8A?:8AA(?=>84>@48?545/8@=>0?28A?;5.859,>6;3C'><>:)<=A@4A)896,<2>B;<=7>:-79:1:?A2:4<:49>>B?98(784A@7>4;+?86155AA@C?0=8%/=;?@9@9#C:?>B@F=5=@DACDEC946,@CG0JB:JIGD9IH8GGG?H%AD>?>CE=G=CGB&D>?BAG%FF8DDB7E@E#DDAB?FBFIA>$B3CEAE?D347BHBBCFEI0JFF;D.IACIADC=B5GGIIIFFBHFFHIEGG8F@@DDAD>G;E>G;DIBD&DEGHCGE5JIJI@BDHF?E?FED.E:C7B?HHFEGFCF$A:AA7I6IDB.=,E72HC(BB<3?8D<7EHHD/DF6*F>;93<4EB@AH=+D8(?;:DC)FC,>+>&E?;=G%;@H?3FF6J@EDIEHADHH>5>GEBDEEIHG=JIEIF7IA*AF@:D?2DG;C3HADCGG<9GBC,?GD(B75B>8F96CA.CAD79E?>';@A@E8F@DDG0F=)7IB+@BB?99DFBA@H:E78AGBFAB)EF@<@:EI9GFH10D+IHDA>''(D4>A'?G;@BAD'HBJ5D6IA;>@F:JH84>HBJ>E(@5C+@148AGCH?@F7HD=HHCG?*A=BGD&>:CH;GC8120HII9@=C;/A/A:I?6@(79>5G4)CAAC@>F=E.@@A5?:AB:DBCGB:HG8H=>;8=>4??FF>F;D?FA?4:8H=7E6GGE-ICG<-@0HHI9A+BD0CD?57DF9C:H:G*AG:G&*;7G/8,:2H4G:'BD8-8251)AHH0D>5,9=F8F:AC1EG49=E?->2@HF:F@FDAC6E/B@??=E=@CBJH@BC@*5EADHA<>>><;AGE1'@B>:=B/2CHEDDE?9FI@A)9F@C>>?<@=DFC??,8>BB@F@F7=A/@BC0FHC&FHGECBDBBADIHHE@@C%EGFCCEB+BAA?FF8?FD===A=<8<573.>CC:>4CA:/DD82&HGB,A8-B@I@GI9BHG:FCIEGCF>AAH;B@F6;EC@CJB(JJ;8IG@DHBGGDA=E6AF@@'AH9CBKJ':92GG(EJ;FF5$;I6E8I @rCer/335/1958_54_CCS GGTCCCGGTCGCTGATGGGGCCGGTGGCCGAGCCGCCTGTCGGGCTGGAGCTGGCCTTCTCGCAGCGCGACCACCGACGCGGAGGCACCTCTCGTCCCGAAATCGACAGAGGGCAAAGTGTTGAGACAGTTGGTGTGTTTGAGGTGCAAAACAGAATGGAAAATATGAGACGGGCAGCTTTTCCTTCATAGCATTTTGGCTACCGAGTGTTGTCCTGTTTCCTGGCAGGCAGACTGTATACGGGATGTGGCTTCTGCAGCTCCAGAAAAAGCAGAGAACCCTGCTGGCCATGGCTCCAAGAGGTGAAAGGCAAACTCACACTTCTATCAGTGCTGATTGATGCCGTGACTGCCACATATATCTCAGAGATCTCAGACAGAAGCTGTGACCTTTTGGCTAACCATGATGACAGCCGGCCCTCTATGCCATCCCAGGCTTGGACTATGTCAGCATGAAGACATCCTCCCTACACCTCACTGATCAGGTTCCCATCCAACATGAACTCTTTGAAAGATTTCTTCTGTATGACCAGACAAAAGCACCTCCTTTTGTGGCTCGGGAGACACTAAGGCTGGCAAGAGAAGAATCATCCCTGGCTGGAGCTCTCTGATGTTCATCGGGAAACAACTGAGAACATACGTGTCACTGTCATCCCTTCTACATGGGCATGAGGGAAGCCCAGAATTCCACGTGTACTGGTGGCGCTACTGTATCCGTTTGAGAACCTTGACAGTGACGTGGTACAGCTCCGGAGCGGCACTGGAGGATATTCAGTCTCTCCGGCACTTGGAGACAGTGCGAGCGGGGGTAGTGGCAGGGAACCTGTGTTATCCAAGGAGCAGCCGCGTTCAGTATACAGCCAGTCTCGCTGCAGGCTTCCAGTGGGCACATGTGGGTACATTCCGCTTTGAAGACTGATGGCTCCCACTTTGATGTTCGGATCCCTCTTCTCCTGGAAAGCAATAAAGATGAGAAGACACCACCCTCAGGCCTTCACTGGTAAGGCAGCTGAGCCCAAGTGCTTCCTTGGTCACCAGGAAGAACAACTGTCATCCCACAATTGCTGCAGAACTCTTCTCTCCCCATCATGGGCCACAGTGGTCTCTTAATTTGATTGTGGGTTCTTTTTGTGGTGAGGTGGTATAACTTTTCTTCAGAAGACCCATGTGGGACACCTCCAAGGCTGGCCTCCTCATAAGCCCTGCCTATACCATGTTCCAGTAAACCTCTCCACCTAGGAACTGTTTCAGCTGCACAGGCCTGGAGGAGTTTCCTGGCCTGTCACGTGAGGTTTGATCAGTAAACCAGTGCACGCTTGGCCACCCTTGCCATTTCTGCTCCCAGAGTCTCAGACTTCCCTTCTGACCCAGTGTTGTGCCTTGATTGCTTTCTCTGCTGCCCTTCCAGGGAGCTGCCCCCGGTAGGCATGTGCCTGTTTCCCTCTCAGCCTGGAGGCTGGCTGGACATCTCCTACGGTCAATGTGCCTCTCAGCTAGTTGGCAGGGTTGCTGGACTGGACTCTTGTTCACTTACCTTTTGCCAAATGCAGAGAGGGAGACCAGTGTCAGAGTCAGAGTGGCCTGGCTCTTAGCACTGACCAACCATTGCCATTTCTGGCCTCGCTAGCCCAGAAGGAGGGAGCAAGCCAGTCGGGTTCCTGGAGCAATGGTCGCCAGCCCTGAGCATGACTCTGCCAAGCATCCAGACCACAAATGCAGGAATTTGGCCGAGGAGCAGCTTTAGGTATGGATGACGACTAAGCCAAGCTACTTCCTGAGCTTCTCTCAGATTTCCAAGAGCCAGAGATGAATTGTGCTGCAATTGCCCAATTCTTAGGATTTCTTCTCCTCTGCACTGCAGTGATTGGTTAGAGGTCATTTTCTTGAATTAATATTAATACAGTT + -'*(&$-(,'$)--#)+-)'-'*'()'*%+(%'*)$*-+"&#$%,,0'*.--+$+,21100/'&1/$%(,,(+")%,$.(5,150-)'$0+-(0/5503-+''-0+$).015*356-21/2/&-.331.2$-//55)56-3+.,5*%.,.%1034/33%343%0+.042-%$2&5532435)3.20640,0*,133$++5220)3-)#+0'14/*033,%,)4620)5,)//.0//-+$+$&4+/0.54015-452/44230+))/121&-0+/,.1--.&+''03(2,400%005.*'(((*0/3,)20.,+#*+$$)+,4$,12*)-$+(&*366340105&4*,.%..1&(+-251/*%.*($)-1+(/%1*-)*+4+%1%/)045/,$"#1()24'1*5-/22134030).(+-'---+0/83,375,25.-5*9)-475973493'29584152516.302&70*),25#,.6:5/55419156%94738428)16-33,54%37917422&&91,+50-.577'5401798*3-1-)4:4055&97;345155,(416/3*2*5(+692543,.18+.5.,)5//.%62'479-.4775507:82432637575*/1&26.$22-/2)',%.-+/4/002.4011455-70*2511644&.42'212&3(-43(((5+4,3)*&,,)./&,0,34/0520-359:7544571'$2775:6771.2)&04592*.'-45/6'3-&7'+-8:6*5.49127/96567558%+2-2:20-/&01&2-553/1269(-%&)$%%+$'2513,%160*7+:536844159827*3-59908:.05960+',/10#/17/4%)2:963224:8:4+4&9342254(+1--40,84+,'23404(11./')1&,/(002..-/+05(2-/1%+0(353131366-(+$21.33&%2,34&,12,6::.55361.51-12/3&/32&4447*9'7059%7:65:0++'742-43'89'.-33-,343093:67;:9,<5%5)5:+5<681=699858'95;/<9;49768=:69<,>36:9:020$2.-/686+;5;87081'),4(7,>;72)847+:-4.(1%(7;<8&51<32/12)3=>A>5;065B->?6=3B7BBB:@)@?4BABBC>A@A0?A?-7<=42)<,/9-7)9>4;=,<3@4?C:98(>:@>?<:9;;?'96:5B=(A?B=<>&=A;=@:;1<=,C>@@5A3<==B;<>7>=;&A@,;=@<>AA@?8B8B>>A;5==AB3>*>12C@:?3:<:9AA=???==>C3>7>98:?:<@@7C<=?,C989A;7:03863*&/76A*54<9<;6<<:.0:8171:5<=,?99(5@;A8A6:37,<7<8>585:=>49*788:/;3938:-=><>0>A958&-;'6747$3/&4:;.8;/;;1+--/-10..*)035610/,25410*21411-126..)1/+/1*601051,2111)5--%065635455-5260,25054,,$*5*-%&($++,%)&%-2*.20(,301.#)$+'/10*.+2-*,$#*./**$/-(+$').+1.-/0'213.650.511*1-1201(50))/223'2(42)0(1-//0*,(,.)(0/'-522(04522,5-(*456.)5,4-5202+5/)''+)/'0'.+-/(-31/0(.%1+(,/-&*010'/(*&2)%+,11.12&)(///$%$&&+0,02-(-.',2/-',((&'+)111,.+.00,0)-%20,,+1,,&)*-/'+0(-.*-(+*11/,*$%)).--+ @rCer/336/25_1489_CCS ATGGGTCAGCGAGGACACGCTCCACGAGAGCAGCCCTTCCACTCTCCGCCGAGGAGAGGGGCTCACCCTCCTCGGGAACCAGCTACCCGCGTGGCTCCCGTCAGGACCAGCCCGCGTGGGGTCCTCCCTGCCTGCTTGAAGGGTCTGTCCAGCCCCGGGAAGCCACCTTGGCCCCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCAATCAGCTTCCCCCATCCCTCCGAAGGACACCCGGCAGGCATCCCCCGGGAGGCGGGGGCAGAAATCAGAAGGGGTGTCTGGGACCTGGATGACCAACAGGGACAGGGGCATGGTCGTCATCTCAAAGGCCCACACCCCCAGAGGCCACACTGAGCCTCCCAGGGAGCCCTCGAGTCCCCCTGCCCAGAGACGTGGAGAGCCTGTGGGGGTGACTCGGAGCAGCAGGTGTGTCCCGGGCGGGCAGCACCACGTCCAGGGCAGCCTCCTCCGCTGAGCGAGTCACATGATACCAGTGCCCGGCCAACACTCCCTTGCAGGAGAAATTTGCAAACCTCTGTGGATACCACATTTCCATTTTTGTGTTGTCTCCAAGGCCCCTTTGGAGATCTACTTTGTTGGTTGTGTTTTTTGGTTCCTTTCAGAGAACTGTAAACCGAGGCTGAAGTGCCCCACTGACTGTGCGAGGGGCAGGGGCAGGAGGACCGCAAGACCTATTTATAATATTTAGCAAACTCGGCCTCCCTCAGATCCCCCGCGAGGGAGGCCGCTGGACCCACCCCGCTGTCCCCCACGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACTTCCCCTCCTGGGTCACCTCTGATGGCCGCCGTCCACTGAGAATGTGGACAGTGTCCAAATTCCTGTACTGTAATGACTAAAAGGCGTTTTCTCTGAGACTGACAAGGCAGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCAACATGTCCCCCTTCCCCCGAAACCTGGCTCAGTGCATACTCCCGTTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCCTCAGTCCCACCCCAGGATAGGCGCCCACCACCTCCTCCTCGTCTCCGGTGGTCAATCGCTCCTCCTGTCCCCACCCCAGTCCCATTTTTATGGCTGAACTGATATCTGAAACAAAACGAAACTGCAAAACCTCGTGTGTCTTAACTCCCCCCGGGATTCCACTGCATTCCTCTGCCCTGTGGTCTGGTGCGTGACAATCCAAAGCGCTGCGCCTCGTGGCCGAGACGAGGGTGCTGTGTCCCTGAAACCCAGAGCCGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACAACACTGGTTTGCAGCCCAGGTTCCCCGCCCACCCATCCCCACCACACCCCGTCTTTTTAGAGGTCTCTCTAATAAATCGGGTAATAAGCAT + 4:4?><=986>=5A;0>;A5<<<;>A8@>9@7?>)@@???B<8<7>/5070?>AA6?B;?4BA9<@>5>>CB7>61;;7?@?=A>AB7B==:@<@=@?>;<:8AB@29:5?@3><:A;:89&?@?<:8>>:?9>6A>??;;46A@81<>373>:<<@1:@>7377:8@7?====<4=1>=179837=629:9<:<579':;17;7/:549%768(&;354576:8=:9<=:=?;7><$9+6474;:=<7?<:743299>=>5?8=>9/>97>94;7;4829:87=30<9<;92?::=9?>5+<2<=>:<5:7;9?862=;;<=,>4%49=8>:484=:5=::81-=<5=180??335:,7:92<:;==9>9;,2<9;==<6::>:8422776=1:68.&5*899=8448==;>86;><<=>;?<7==>=77?6/=;78>5;:<95=95704758;;=5<3<&34/27?7<;5;=*697;56:49689><.<:4<5;?4?>;9<75;59::?;=7:=<:?7,=;:=:<==?;>>=:=.:9<4??;:?=7?0<9>=:7:1977)27;188:8%5<9667;.;6=398;2587(796=:3>>+946.97054:859-<:;:<=<9>5619%933?=;995:=>>:977)85<;;6>>:=?:>9<3.7??=?8<>6+;9=8>6=<;;8=;8;><.;;<9;><<568>?;=>:2<5074;>==0/:>=66=37259;6+91874)5:>7/84=>>;=776=9-7=>=831459:6=4.3<;6>6179;789'5/=149<53:.:=9;*;5;;3<5695;=>486,9:;868<+:;5938;<;>:=85;>8:19:9:0>:98648<63178<68=>=::59=;><6;;3?>:?9;45788:*863985:=8&;896+8%99757789598/:36:88395).-72.7886987654*855639'454/88-*5(/0*/239*3,424(4065:642#55.166:989-/1+-3+&87065639824258.6::8/+63;23:8,,.6:788943.8,01/3995/89:521/:82&23,..24551*475392/#-4780987369;792;;0173%35559584981666194910'6650()49228564.$/55488307./,682498843532.02452458;67929759159::5.339:717556247894576(20(%,/508;9869;5:85013(56/*0/*222969:2684;28::/659630-33392:/728575;86641,6;8:675699558,5189:6*5:9/262/03::78;7./.869645+35888667636::5445;8/8766.8993530.3,41 @rCer/337/2077_59_CCS ATGGGGCGTCGCCCCTCACGCTGCGGTTGTCGCTCGTGTCCCGCCGGCTCGCTCCGTGTCGCCCTGCACTGCTGCGGCCGGCGCGGCACCATGGCTGTGTTTGTCGTGCTCCTGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAGATCACCGGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATACCAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACCTGTTTCATCGTCCTCGGGCTACTGTCATGGTGATGGTGAAGGGAGTGGACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCATACCCTTTGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGGCTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTACGCCAGCTCCGTAATCGCCTATTTCAAGAAAACTCTGTTCTAAGTTCACTCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCCGAACTGCAAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTGTATTCACTGGAGCTGGCAGGTTTGGATGAAATTGGGAAGCGTTACGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTTTGCAAAAGTTTGCAGATGACATGTACAATCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTTGTTAGGAAGACAAGGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCTGTGGTTTTCAACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCATCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAACGTTCCCTGTGCCAGAATTAGAAAAGAGCGTTGGAAATTGGCTGTTTTGTTAAAATATGTCTTTTGGTGTGCTTTAAAGTAGATAGTATACTTTACACTTACAAAAAAAATCAAATTTTGTTCTCTATTTTGTGTGTGCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGATGTGAGTCCCACTGTGGTATAGATTCCATAATATGCTTGAATACTATGATATAGCTATTTAATAACATGATTTCATTATGTTTAATGAATTTGGAAATATGTACTGAAAGAAATGTAAAACATTTAAAATAGCTCATGTTATTATGGAAAAAAGTGCACTGAATTTATTAGATAAACTTATGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTATACTATGAATGATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACGGGAAAAGGTTTTTAACTTAGAGTGGCCCTAAAATATGGATGTGCTTATATAATCACTTAGTTTTGGAACTGTATCTGAGTGACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGACCTACATGGTCTAGTATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATACAGATGCTTTTCATTATACACACAAAAATCCCCAAGGGGCATTCTGAGGCATGAATATAAAACATTTTTATTTCAGCAACTTTTCCCCTATGTAAGTTACTGTGGTTTGTGGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAAATAAAGTTAATAATGATTC + KKKKK&KKKKKKKK/JJKKKKKHKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKIJKKIKJKHKKKKHKKKBKKKKKKKKKKKHKKKKGKKKKKJKKKKKJKKKKKKKHJKKKKKEKKKKKKKKJKKKJKKCKKJKKKJKKKKKKKKKKHKKKHHIKKKKGKDKKKEJKKKKCKKKHK8HKJKKBKB,KIIHKKKKJKKDKKKKKKKDKKKKKKKKKKKJFKKJJKKKKKKKKKKKKKKKKKKKKK=JKJKHKJKKJKJKKKKKKKKKIJKJK;KKKKJKKKKKIKEKKKK/JKCKKKKKKKCCJEIJKEJJKDKK5JKKKIJKKKKKKKKKJIJIJKKK(KK/KKKKKKKKKK@KKHJKKHKK?KJJKKJGKKKKKJKJKKKIJKKKKKEJKJKKJKJKKKKGK=KEKKKKKJK8KJJKJ=5I;KIKIJJK;JKKIKCGHKDKKHKKKKHKK8KDKK@JIJKJKIDKKKKEKFKKKKKKKIJKK?KCIHJJKKKKJKKKKKHJKKKFKKKKKKKHJKKKJKKKKKIKIKFKKJJKKFJKKJJKKKJFKJKKGGFK@?KK4KJIKJKKKKHJJKKJKKJKKKHKKKJKKKJHKHJKBJKHIKHKKKBKBIKJKKIKHIEIKEKJKJKKKKEKEJJJ=KKKKJKGJKKKJJKK@KFJJKKKKIKKKKKKIKKGK?K2KKCKKKKIKK7DJHBH?FIJK+IKK9KFJ9K>JGJKIJFBKG@IJJGKHGFGKKFFAKFDJKIICIJJKKJ*JBI9GGGIIHKIA/6;5.6.199/85/6545;67096>;80385434387*78./2/..()30+2;7;=>4757-$9;2=?9=9;=26=88,603:.67(6=6);9.:/(68657-5075%643214)9019635320:7;12=<=..+:583::/43762;8=;63:3:>.>=6798:67-89098;793(7575:79:8>:42/-293827=;?598:<:<476(9>9170/56>:19;5745/378:665;;6:.7<.<657=:>6;<9702::/6:?::-7<17152937=0=7,2,4=14922,55390*816062-90471+64*7132782/22154547(0948:8325210-73),65/973-5531644593;981878486/)2.40)10855955666.+2474.-,/28:183367+2(/$39529664),62*,1245/63745;58+0.)3119916.6737+4)9:2888.1093+219+/501)45::/:99;985:6426764893142/$847829:926675144-796986)9961)/664(74629:272)67666(54453'783+1'/93284++85,985109;/729758:1+355516.42(.461-13.2076.-63342&670410194637)446632'22(7326-5986+747150*25--528&646+3134-8.86-;8775/1345:07746,+0.6//11/005/'$34/,(*042.3349701,05258277%539/8;752-27-5492(*(117/32+./5:15486:554$.75675814),-+0+-:-.502-79442489425+/217389749279659/52/11:70131395:7;15782(357860)3/43248*58-*&3896756674748)9:59.02,3150%487574765+33/458253365294+41-316566343/974(1,458335*7,186:2(1-+4422%20297:6117,24;7568,8817,44;55997:893+475+354$4:79,:6;592*6/1974/85480558728.55-0/136036*,626:293613;8552-508228:574866422/03%5,'&13/2.42+.+2.0,'&/2--2+32054&.7+34,37.,(/35519/2(44,3:6583-030%,94-,4,,0*769/(3./(-+5452-674763.,-714+529679.4864733905/4/,3611*94657,238/172:27882*582867%50:6937.8*9225,89385444/4.*-/-155-3876-/0243386485382143-76-5638788040+48*127:-:2796151184343'356,/85111(62-7.596+277264934479+:5647835/+/520*12*2-10+01/+055624-,.6;9:5419-641/3.11.(64866611*-65586:2..58,30065.7:8:4*.95*%2423403352281495456843;-5953'/965;14433/43604384/5/19524588;8(2/2.1.21--25411.07'75.5-24023/2326.9596006,015623,0+/1.01*.3*2*/34.1,50.1*.0-4-1/&05*/1,(.&-54465)(5(53143--2/36,.4220545/1)563543066332315,1,1245.4.101.)/54*5540400542/50-14,/4)%3.5330/3$'2,432165616601-550233'.-24*2.)2/234.443/-0 @rCer/341/25_2137_CCS ATGGGCAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGCGCTTCTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGAGAGGACTGTCCCCTGAGCAGATTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTAATCCCATTTGCCCCCATTACCTGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCTGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAAACAGTTTCAAACTGTCCTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCTCCACGTTCATCCCTCCACCTTGGACTTTCTTTTCGCCGTGATGGTGACCCTTGCGCTTTTTGCTGGGCACTGCGATGGAGGCACACAGTGCAGAGACAGGGACTGGGTGGCAGAGAGGACTGTTGACATCCAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGGGGAGGAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCACAGGGTTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCCTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAACCAGAGCCACAGCCGGAGAGTCCAGGAAGACTTACGCCTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCTGAGAGATAACCAGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACACATCCTTCCTACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTAATATCATGTCTATTATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAATTGAAATAAACAATAAACTTTTAATG + 32'1318465711183;36;/5:80308/1,73'6)4:-/,.5/85425/+123)#.,#,214&,'624/1&2*#3745+7688)9.13:,.-1146--7&668135(13769;9/2;.4:*,**26354.+.23+627/2::%.+5429606.6878(4136268-5/51(685'(&8/84*3#&+*+,+310242,641-.0.'98'565-46:6&2**96+3,78+01,,1*1.1+.-50%10.2657.55060-65962(,,-1-5440.%54527:9:4;69(12%33331,*$853(45+3-03.16+02515::8;6.688+9815945/6576685-+98+8:95133373'63356*83+3004430/0$6313774227((98861'87747,898;/74,-1,72251412(56%20.,/487+0.01.2,/8.7757$),68011:4:87:47)868&23/94;:83.35329,756-5762550)28393407'43/5/36:,3:94(*$.1054.3)(*$(/3(0-22,//2/+-20,0.0--/1+(//.-1/**0112-0./&/+11101&-%/2+.)/,*-*--())+'&+%/%(..4%//-(0*/0&.2/2555%20...04./1(#-1+&$/.*0&/0)(3*'%%/1.(,)3(33101632-01/1./.0/('$-.4*)(1,//*.'0/'0,23,'2164+44661036(0(.-)/26&1//-04*0%/'/1$330-.&033.*2*541*425662*%(55223053+)-+1//()$+4+016-)56)(-15264+3444+4/35(+)31.6632-415)342.%02/425211+550/&&-412.+3461..+4/*153(3(,/2.+,44-/56652+22523.03./($#.,40*-.,466441.+-20053665-1+11/3031../-'5/*1+/14,'$+-,%(132/2405.-.-44113(0,)-0/**$+*0323'(,.'.35443442-..54)2/5.&'(*)&3.-30%.+12034/061/%444./44.10)-2-06,''055(1(2-1,+&264664+15++(,./53..4(025151(22+4/*/*.0/22/3.4611)224,5)).+-126*0,/..0365-5/-22/21-.4+313/-33&/23/(/+3.4053*2*040-.30+225.15321++1/,.2100.()-.501/$450/,#11.32$(&%/+-/5-21'/.,5/%-226*'-+/'/)-*4,&-,256-%4-0++.'&*%111626)34;1199:57/2'7658307258:5'44974*$35273(74565/1)2,+2#757943219+/12++32-0404)3841,69.,$4191573$2(.'6188654081193,5.466/299897%5333353,4+2/240-,4.101951:4;6774/9466:69/:883-4.08(5&74613,'4997892-/)1-)8'74/3354,-35'04%13157983577:3;16/63.+1*,#%)+$840/,%*$3+9,9586889203,*10.2),..3+10&.9)4607207::4932.7-1.23;5739.'-2-708&034%47:44845/46+1*/)0,*),+)../..-1-1,-&/031,4958+85914/2645+-&-900/$$469:0,%5$)1.,-/621-2441&)%2%,(524559-87(86.-68602-81.+287&465.2)0,00)&.51/.03/)#$%-/2./*'3%/06.5&30).&(55475*5292271+/01-'01-./010*.%+,,14*3:040-54.430/*&'/.%..1/,8+521+2/)3+0528973306/75751)(+43)022/,351281'.12210353--2(01&-1*..*%.056919562,,*//5617.-'2-6292(876).+5.8)0)*'2/'5555-1.&88561*4546.562,389656677:6:81*243/1784(/39786'-0,-'+59752645845.55*41/)//145:94-833*11-2,0654277.4+::9:94854(-1&.(891%8&/819:82567(22.679*762++4. @rCer/344/25_1708_CCS ATGGGGGCAGACTCTTCCCTGAAGCTGCCGGCTGAGGCCGGAGCTGCCGCCTCCATGAGAGGCTTCCTCCTACACCCAGGGCCAGAGGACCCTTTGCCACCAGAGTGAGATCCTAGAGACCATCATCCTGGTAAATCCCAGTGCAGACAGCATCAGCTCTGAGGTTCACCGTCTTCTTAGCAGCTCATCAGCTCATAAACTACTAATCTTGAGTGGGCAAAGTTTGGAGCCCGGGGGAGACCTCGTCCTACAGAGTGGCACCTACTCGTATGAAAACTTTGCCCAGGTCCTTCACAACCCCGAGATCTCCCAATTGCTCAGCAATAGAGACCCTGGGATCCAGGCCTTCCTCACCGTGTCGTGCTTAGGGGAAGGTGATTGGAGCCACCTGGGATTATCCAGTTCCCAAGAGACCCTGCACCTCCGGCTAAACCCTGAGCCCACGCTGCCCACCATGGATGGCGTGGCTGAGTTCTCCGAGTATGTCTCTGAGACTGTGGACGTGCCATCCCCATTTGACCTGCTAGAGCCCCCACCTCAGGGGGCTTTCTCAAGCTCTCCAAGCCTTGTTGCTACATCTTCCCAGGTGGTCGTGGGGACTCTGCCCTCTTTGCTGTCAATGGTTTCAACATCCTGGTGGATGGTGGCTCTGATCGCAAGTCCTGCTTTTGGAAGCTGGTGCGGCATCTGGACCGCATTGACTCGGTGCTACTCACACACATTGGGGCAGACAACCTGCCAGGCATCAATGGACTACTGCAGCGCAAAGTGGCAGAGCTAGAGGAGGAGCAGTCCAGGGCTCTAGCAGCTACAGCGACTGGGTGAAGAACCTTATCTCCCCTGAGCTTGGAGTTGTCTTTTTCAACGTGCCTGAAAAGCTGCGGCTTCCTGATGCCTCCGGAAAGCCAAGCGCAGCATTGAGGAGGCCTGCCTCACTCTGCAGCACTTAAACCGCCTGGGCATCCAGGCTGAGCCTCTGTATCGTGTGGTCAGCAACACCATTGAGCCACTGACCCTCTTCCACAAAATGGGTGTGGGCCGGCTGGATATGTATGTCCTCAACCCTGTCAAGGACAGCAAGGAGATGCAGTTCCTCATGCAAAAGTGGGCAGGAAATAGTAAAGCCAGACAGGCATCGTGCTGGCCAATGGGAAGGAGGCTGAGATCTCCGTGCCCTACCTTACCTCTATCACTGCTCTGGTGGTCTGGCTACCAGCCAACCCCACTGAGAAGATTGTGCGTGTGCTTTTTCCAGGAAATGCTCCCCAAAACAGATCTTGGAGGGCCTGGAAAAGCTTCGGCATCTGGACTTCCTGCGTTACCCTGTGGCCACACAGAAGGACCTGGCTTCTGGGGCTGTGCCTACCAACCTCAAGCCCAGCAAAATCAAACAGCGGGCTGATAGCAAGGAGAGCCTCAAAGCCACTACCAAGACAGCCGTGAGCAAGTGGCCAAACGGGAGGAGGTGGTGGAAGAGGGAGCCAAGGAGGCCCGCTCAGAGCTGGCCAAGGAGTTAGCCAAAACAGAGAAGAAGGCAAAAGAGTCATCTGAGAAGCCCCCAGAGAAGCCTGCCAAGCCTGAGAGGGTGAGGACAGAGTCAAGTGAGGCACTGAAGGCAGAGAAGCGAAAGCTGATCAAAGACAAGGTAGGGAAAAAGCACCTTAAAGAAAAGATATCAAAGCT + 72)::9<:*;7915.31<;179=<:<37>:;985;4:<;=;49=>461:48=3;:52<89.21289;;55-66.(<=9;8=7?6=82;629846:;:=<6=976:<:058059247>5.08.602637:671-::5&332=08970-3:<:8.142:;>36:285>69=<>730;94;084944989>9884:9:3135,36897>88.<765827793==>.?>=?9;170+53.53534=1049=?75396571,;9:8755762:>802-7=6318<80:<820:586565(,5,;;=<8>?78107:6;3<::812596?;=240<3;853=69257,1707*;8887961/14+.35*/(--)23&,9:<7;46?17345=>9?:7<.<9;<:0=24:=7%104<+9<8,3/43;=6>=2:=9>>777-9;7467:)499220//'.6+:5:3==<29:=8)873135008;<>;44;(:59;8/591735:;629;837948655345'6699:375:6(869545?:9:6/9049;2<=3;59?8?748<49875,509):9;:<<072139/:=>;;<7:>1=99738=9>=8-97799?29:8.:9.8;=:67<=?8:<:/3;8=;6;2;=>>2;62&9501&56527+878<939;<*868<>3594/:;7<;:2,00,6<:>;6.1778241::;<;.;=<&5771361:39*67-:7;:=3=72;.12.+47252664)35/50;80<>><10376<98=:<:,60*;:-<=:<;:<8;3<778=:<<756:4=;9>3?;<<<=9?;=7:/<8:9667<>?:?2:9?877)9=78;5:67<648;6*<99870:89?=9=;:4::74086%<6:,<<=;;+1,3:049=88=::7==15-<;:*<=;<:329;9:;>:;6;-9>9==15;1;>=8879/0:73<925==7;36257379<4:;9744:9;30.+0><8:/:;625=/><-12=4;7=89=<8798580*9919,8441:51(5571461,548.:0866591,33:556:72754/6:64.3529&3253188)55648-548:46&52057979;81,$0492%1222:5/31247-6-82*:736754:;9::5=21<;=;6538;?82+=2788=6986=:=9>=><<74833:325/79969:=9185<*9=8102<1<3=435;;9828622=<-====169186?;8?>81=>0-7:68'90'35>;;;'8:$386?21<:7-1;8.>9?>>4:*46:9<2:;.95.271>:=78>;>>3:3.51:80930>0;9;8;>99<<*99;):5=324*+90(=;84:9:?>562>:9953(71267969;/)7,636881>>>2?>::?==900=5=96259>?;=89;7.85*/6)8+;>=7>:9;97+68/9,04-:4/%00097<+5/80)54??:,6<0366710;0=;?:?>>67:53:'3734066601:8;99:):7==<74;789:8==(88287;=4;<523-/2:6/<*==2><8;66>;?<:16;:=>;<=>>8;;:595;76>9=+44:82**77<5:;=87253648=<>99=,<9=8;>4<9>36<<8<49+771&039:===;8.=;36; @rCer/346/1534_59_CCS ATGGGAGACGGACGGTGGCCAGGGATCAGGCAGCGACTCAGGCGACCTGAGTGTGCCCCCAGCCCGCCATGGCCCGGCTGCTGCAGGCGTCCTGCCTGCTCTCCCTGCTCCTGGCCGGCTTCCTCCCGCAGAGCCGGGGACAAGATAAGTCGAAGATGGACTGCCATGGTGGCGTGAGCGGCACCATTTACGAGTACGGAGCCCTCACCATTGATGGGGAGGAGTACATCCCCTTCAAGCAGTACATTGGCAAATACGTCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCAATACATTGAACTGAATGCACTACAAGAAGAGCTTGCACCATTTGGTCTGGTCCTTCTCGGCTTTCCCTGCAACCAATTTGGAAAACAGGAACCAGGCGAGAACTCAGAGATCCTTCCCAGCCTCAAGTATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTTCCAGCTCTTTGAGAAAGGGGATGTGAATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCGGAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTCCACGACATCCGCTGGAACTTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCTGTCATGCGCTGGCACCACCGGACCACGATCAGCAACGTCAAGATGGACATCCTGTCCTACATGAGGCGGCAGGCAGCCCTGGGGGTCAAGAGGAAGTAACTGAAGGCTGTCTCATCCCATGTCCACCATGTAGGGGAGGGACTTTGTTCAGGAAGGAATCCGTGTCTCCAACCACACTATCTACCCACCACAGACCCCTTTCCTATCACTCAAGGCCCCAGCCTGGCACAAATGGATGCATACAGTTCTGTGTCTGTACTGCCAGGCATGTGAGTGTGGGTGCATGTGGGTGTTTACACACAGGCCTACAGGTGTGCGTGACTGTGTGTGTGTATGGGTGTACAGCCACGTGTCTACCTATGTGTCTTTCTGGGAATGTGTGCCATCTGTGTGCCTGCAGCTGTGTATGCTGGAGAATAACCACCTTTCTCTCCAGTTCTCCATTCCAATGATGATAGTTCACTTACACCTAAACCCAAAGGAAAAACCAGCTCGAGGTCCAATTGTTCTGCTGTAATCGATACCTCAACCTTGGGGCCAGCATCTCCCACTGCCTCCAAATATTAGTAACTACCACTGACGTCCCAGAAGTTTCTGGTCTACCACACTGCCCAATCCCCAACTCCTCCTTCCTGAAGGGCCCTCCCAAGGCTACATCCCCAGCCCACAGTTCTCCTGAGAGAGATCAACCTCCCTGAGATCAGCCAAGACAGATGTGAGAGCAAGGGCCACGTACCCCTGCTGCTTCAGAGGATGTGCCCTCTCCCCTCACTGGTCCATTGGCATGAGACTCACCCCGTCTGCCCAGTAAAAGCCTTTCTGCAG + KKBF2<9?HJ-KHKFDKIKAKEKIKJKJKIJIJKKEKKJIIEIHGK$GDECJJ@KKKKKBHGKKHKKJIIK>KKCKHCAH?BKKKKKKKGKIKJKEJK=BBFIJKJJHKKKJBHJCKK>D9KFHKGHIKJKHFI7EJKKHKKGKKBDJHJIJHIHKI>KKKKHFKFKCJKKJ9KKIDKKJKEIHIB+KBGJ@A36GBFKKK@KKJKK:DKJJDKHKJKK:KK@J:JJJKJIAJKIDJFDJKJDKKJJHJJK8KJK>KJKJKBHKHJHJI;FFF;DH>?B7FA0HD7G?@?EJIGEKK3KHFJHK9GKJKHHJEKIKKK@JJ+JKKKDKJKAKK2KGJKK,KJKJKFKKKKIHHFJKJKIKJHKIAJKAEIJ>FKKGKJIAIKFFFC=KHJKKFKKJJIKIGJIE7E>F7DJEHFKJJ@GJKIJGH8:EJKEHFKJKGKHEFIIEKIIKEKJKJEH?IKHKHKKJJKKKEBCJJJD=IHKBHCGBFI9E>JJEJFJGBHDBD'KGI@CKKEGE=BHGJHKJK=HJKJKKIKFKHIH@KHKKCEHD?KKAGKKIIK?>K6KJJKEIJHFKGFKHJCDIHGJJJK9KKEKJKIKIKKK;@KKKK2JKKJKKJ8KIJJIAKIKKJKDKIKJEKJCHKJ:JJJIJFIICIBHJ7JKI3HKJ1?KKKGKKHJJIJFBKCK4HKGHKJIKJKEJDKFJF?IJJJIKBKK>BJ5HIIKKKKKBKKBKFKIIIJIEKK?KDKKJBDCGCJKJKCIJJ:KKGHFAHH4HKKKKGFJCBIJK9EKKKKFJ9JKGHKDHIJKGKJKKKAKKKDFEGHKHIJKK@IGHBFJBKAKKKJKKKIJJIKKHKKKKKKKKKHHKKKFHEKK?JGBBKHKKJKJKGFIJJIKKKKGJII6CKKJKAKJ*KBJHEIJFKFA@KFF>IJFKGJKKIFKJKKBG$IKIGKFEIH1KKBKGKKCKH>JIKKKKKKKKKEKIGJIKHI4IKKKFGJHKKAKJKKJKJIKCEKK;JK;KKHKAKKKKDKEDJJIKJJKKGK;KKDHIKKIJJK?JKKJKKKGJKK;JKEFJKDKIJ@K@ICI@EJK1=BHKKF%JKEJKJDEKCFJDKHJEBDC?JHJJIJKJ2JIIIGKK;CGKKKKAJKIIK=JKJKHI @rCer/351/1691_62_CCS ATGGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATCTGATGAGGAT + JKKKK8JKKKKK5GJKFIEAJKJGKKJKKKBJEJAKJKHJKGCJCHHKHKKJIKKKJKCJHKKKKJKDHJKCCIJJB=KJKKK?KKKCBKKKK:GKKAKEJBKKKKCJKJJJKDJJHK9JK?5KJJGGJJJKKKKGKHKKJJKKK9KHKKKKKKKHKHKGIK?CGKKKJKKJDKJH@KK4JJJ8KHIKFHIJKFKKK/KJDHKJKKJKIKGKJDKKKCIKKKHAK:KJDEKJKKEKKK:JJKKKK8KFKKKK>KKK6EK5JKJKJKJIKKEKJJJJHJK6HJJIEEJBIIKHKJDKJJ=IJIKK7JJBHJKJKFI5JDIKKKKA@C:JGHIKJHDGGAFKHGKK9KKIKJ3IKIEJBGI.JIIKGAHDKKKK?KKKHKJ=KKHHIIHKHIKFKHKKIHJKKKKJKKKGJJKKKJJIIGFJCKDFF6GDFKKKIJHIKKGHG?K6KJJK4KKKK@IIJKFKGCK7JKA>9KIJJI?BJK@KGKIKEKKKJKJKIKKJJJKJBC>GAHCE/GKKKJI>KJKJKJKKK=>KJKK>KKKICJKKBJKKIKFKFKKKJKKK>KKIKJKKKHDHKBHHKKIKKKKJEKKD@JJ5KJBDKKKKKIIKK?KKJKKJI?JKKHKFKJJKKIDJKDKKJJGHJKJIJDDEIKK0KK@KIBKJGKIJIKHKJKKKEKK=KCKICK3HKKIK8KK2KHKBHKDKCIKBKE;JIKHJKGKBKKKKKJKKJIKJGD=H>HIKKKI8KIJKJJCKJKKKKJFIKKKIH=EFEK?BKKKJJKKCKJK1KJKIJ1IAJIKKGKGKJDKHCHKDJKJKI:KKHK>KHKKGJJJHKKJKKIDGGKKJKJJ>GKKKHK?KIKJKKHDJIBJIJJJCGGIK@KKJKKJH6&'+>..4)2&@ @rCer/352/27_1749_CCS GCGCTTCTGCCCTGGCCCTCTGCGGGCCGCTCCGCCGGTGCTGTTCCTGGGCGCCTCCGTGCTCTCGGCCAACGCCTCTGAGAGCGCCCACTCGAGCGCCCGGGAGCCGGAGGGCGGCGGTCCTCGCCGGACCCTCCTGTGGGCCCAGGGGGACAAAAGTGGCTCTCAATCCAGCACATGCACATTGAAGCAAGTTAAAGGATTTAATATGAAGCACAGAAGCAGATAGTGCCAAATAGCAAGCAGTAGTTGGTACAGCATTTGGTGAGTGGGGCAACATTTCCTTCTCCTGCTGCTGAGATGGCAGAAATTAGTCGAATTCAGTACGAAATGGAATATACTGAAGGCATTAGTCAGCGAATGAGGGTCCAGAAAAGTTAAAAGTAGCACCACCAAACGCTGACCTGGAACAAGGATTCCAGAAGGAGTTCCAAATGCTAGTGTGATAATGCAAGTTCCGGAGAGGATTGTTGTGGCAGGAAATAATGAAGATGTTTCATTTTCAAGACCAGCAGATCTTGACCTTATTCAGTCAACTCCCTTTAAACCCCTGCACTAAAAACACCACCTCGTGTACTTACGCTAAGTGAAAGACCACTAGATTTTCTGGATTTAGAAAGACCTCCTACAACCCCTCAAAATGAAGAAATCGTGCAGTTGGCAGACTAAAAAGAGAGCGGTCTATGAGTGAAAATGCTGTTCGCCAAAATGGACAGCTGGTCAGAAATGATTCTCTACCTGTGTTGCGTGGTGGGTCTGCTGCCCGCCACTTCTAATCCTCATCATGAGAACATCAGGTATGGCATTTCAAATATAGATACAACAATTGAAGGAACGTCAGATGACCTGACTGTTGTAGATGCAGCTTCACTAAGACGACAGATAATCAAACTAAATAGACGTCTACAACTTCTGGAAGAGGAGAACAAAGAACGTGCTAAAAGAGAAATGGTCATGTATTCAATTACTGTAGCTTTCTGGCTGCTTAATAGCTGGCTGTGGTTTCGCCGCTAGAGGTAACATCAGCTCTCAAAAATATTGTCTCAACAACTGGAAATATAAAAGATTTGCAAACTTCTTTGTTTCTGTCTCTGCGTTGTATGCCATTTTATAGTCCACTCCCTGAAAATGTATTTCTTCCAGAAAGTCTGGAGGAAGGACCTATATTTTTAGAAGTGAAGGTATATTCTGTCACTCAGCTGTATTCACGTTTGAGCAGTTCTGCAGTACAACCTGCTTAAAATTCTCCCTTTGCATGTTTTGTAAATAGGCTCCAGTTTTGTTTTTTAAAAGGAATTTATTTTTGCCTCATCAGTCCACACAAGTGATTCTGAATAGGAGAGAGTCTGTAGAGAATTGATTTAGATAAGTGTCTGTGAAAGAAAAACAATTTTTTTGTCCTGTTTCTCAAACACTGTTAAGCAGTTTTGTTAATAGACATTTTTGCATCAACACTTCAACATTAACACTTTCAAAGTCATGGTCTGGTGCCAGATTTGAGAAACTCGAACACCTAATATTTCATAACCTTCTTCATTAGGTACTTGTACAGATTAAGTTCTAACATTTCAGCAGTTTAATATGTGTGCAATATGTGCATTCTTTCATTTTAGTTTTGCACTTGGTTTTCTATAACGTACGTTTTTACTCAGTTCATGTGTGAACAATTTAAAAAAGTACAGAATAAGGTACAAATGTAGTGTATTTAATAAACTGTCAAGC + 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@rCer/353/24_2109_CCS ATGGGGAGTGACTTGAAGGCGGGGCAACAAAGGGTACGGCCGATATGGTGCTCCTCGGCCCGCGCTTCAATGGTTATGACAGTGTTAACTCTAAGGGGAGAAGGAATGTGTGACCATTAACAACGGTTAACTTGCATTCCCCAGATAGTTTGGATGAGTTACAACCCAAATCTGCAAACTCAATACAGCCAGACCCTGGGAAGTGACCCTCTCGAGCCTCCTGTACAAGTCCAGGAAAAAGAGCCTGTTTTCCCTTGGACAACGTGAGCAGTGAATTACTGCTCATTCAGAATTACATGTCATGTGTTACTGATGGCCAGGTTTAGATACCAACCTATTTCTAGAGGAGAGGTGATTTGATAACCTTTTCAGATATCACTATCACTAGGCAGAAAAAGGGTTAATACTATGACAGTGTCCTGAGGACAGTAGAGAAACTGCAAACTGCAGAAGTACCTGATCTGTGGCCCTTGGCCAGCATCTCTCCATATCCTGATTCTGTAAGATCAAGTGTTTATGCAGAAAGAGAAGGGACCGATGATTTGAATGTGACCAGATGTATGGCACGCCCTTATTGCCATGCCAGCATTTGCTATTCATGATGTTAGTATTCAAAAATCAAGAAACACTCTGCATGGGCCATTGGTGTCTACTAATCCAATCCGTTGGAAGAAAAGACTGGAATCCACCACTTACTAGCTCCTTGGGCCTCAGTCCCCTCTTTTCTGCCATAACTAAGGACCACCTAATCTAGATGGCTGCTGTTATTGTTCAAAGGAACATCTTTAGAGCCTCAAGCCCAGGAATAGTCCATGGCAGGCACCTGGTAAATGTTAGTTTTCATTGTCCTCTCCCAACACTATGAAACATGCAGCACTCTCTGCAACTGCCCCTGTGGATTTCCATAGGCAGGAGAGCATCTAGTGTTGAGTGGAGTGGTATTCTCAGAAACGAAGCCCCTTTCCTCATTTTGTGCCAATCTCTTCAGTCATTTGTACCCTAGTAGTATAGGGCTTTGTCAAAGTCACTGTCATCTAATGTTAACAGTTGTTTTTGCCAGATGACTTTTTCAAAAAGTGACTGTTAATGTGATAAAAACACTGCATGTAGCCAATTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTACTGCTCTTGTTGCCCAGGCTAGAGTGCAGCGGCGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTATTCTCCTGCCTCAGCCTCCCAAGTGGCTGGGATTATAGGCACACGCCACCATGCCCAGCCAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAGGTGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCCAACTATTTTCTTATTTGTTATATATTTATTTTAGAGATAGGATGCCATTATGTTACCCAGTCTGGAATGCAGTGGCTAATTAGAGGCATGATCATAGCATACTATGACCTCGGCTCAAAGGACCCTGCAACCTTAGCCTCCTGAGTAGCTGGGACAAGTGTGCACCACCACAGCTGACTAATTTTTAAATTTTTGTAGAGATAGGGTCTGGCTATGTTGCCCAGGCTGGTCTGGAATTCCTGGACTCAAGGCCTCTTCCTGCCCTCAGCCTTCCAAAGTGTTAGGATTACAGGGTGAATACCCACACCCAGCCAGTGTGAATTTTCTAATGCTGAGTAAGTTGTGATCCAGAAGTAAATGTATCTGCAAGCTGATTTAAATTGTAGATTTTCTTCTCATTGTGTATTTTCTGATGTTGAATAAAGTCTGAGTATTAACTAAAGTTTTTCCTTCTTCTTAAATATGTAAGAATTGTCCTCAAAATCTCCATTCTTGAGCACAGTAGTAAAAATATTTTTACATACATTGTATTTCAAGGGTTCTGCATAAACAACTTTGTTTTATTGTGACTAAATTTATTTGGGATTTTATCAAATATATAATACTGAGATGTTCTCATTCCTTTTGTGAAAATGGTCTGGTTTAAAAACCACTGCCTTC 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@rCer/355/2292_59_CCS GGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGCGGGGGGCATGGGCAAAGACTACTACCAGACGCTGGGCCTGGCCCGCGGCGCGTCGGATGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCCTGCGCTACCACCCGGACAAGAACAAGGAGCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCCGAGGCCTACGACGTGCTCAGCGACCCGCGCAGCGCGAGATCTTCGACCGCTACGGAGAGGAAGGCCTAAAGGGCAGTGGCCCCAGTGGCGGTAGCGGCAGTGGTGCCAATGGTACCTCTTCAGCTACACGTTCCATGGAGACCCTCATGCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACATTGATGACCCGTTCTCTGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCCCTTCCCAAGAGCCCACCCGAAAGAAGCAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTTGAAGAGATCTACAGCGGTTGTACCAAGAAGAATGAAAATCTCCCACAAGCGGCTAAACCCCGACGGAAGAGCATTCGAAACGAAGACAAAATCTTGACCATCGAAAGTGAAGAAGGGGTGGAAAGAAGGGACCAAAATCACCTTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCACACAATATCTTTAAGAGAGATGGCTCTGATGTGTTGATTATCCTGCCAGGATCAGCCTCCGGGAGGCTCTGTGTGCTGCACAGTGAAACGTCCCCACTCTGGACGGCAGGAACCATACCCGTCGTATTCAAAGATGTCATCAGGCCTGGCATGCGCCGAAAAGTTCCTGGAGAAGGCTCCCCCTCCCCAAAACGCCCGAGAAACGTGGGGGACCTCATTATTGAATTTGAAGTGATCTTCCCCGAAAGGATTCCCCAGACATCAAGAAACCGTACTTGAGCAGGTCCTTCCAATATAGCTGCCAGAGCTCCGACTGACCAGGGACCTTTCCAGAGCTCAAGGATTCTGGACCTTTCTACCAATTGTGGACCATGGGAGGGCCCAGGGAGGACTTTCATACTGCTGAATGTTTTCCAGAGCATATATTACAATCTTTCAAAGTCGTACACTAGACTAAAGTGGTTTTTCGAGCGATAGGGCATCAAGGTGGTGGGAACAGCAGGAAAAGGCATTCCAGTCTGCCCCACTGGGTCCGGCAAGCCCTCCGGGATGGGCCCACATCCTCCTCCTCCAGTCCCTGTCCAGGGGTAGAGGCAGACCAGCAGCTGGGCTTGATCCCTCTGTGTCCCTTTGCTTTGACTGGTAGATAATGTCGACCTGCTGTCTTGGTTCCCAGACCCCTGTACACTCCTCTGTTTTCTGTTGTGTGGATCAGTTTCGTGTTTAATTCTGTATTTGTCCTCCACATGTCTTGCTCTTCCTCCCCTGGAGAATTCGTCCTCTCTTTGGCCATCTCAAATTGAGAACCTAAAGTATTCCTGCAGAACTGGCCTGGCTGGCGCCCACAAGCAATACCTCTTGTTCCAGCAGGACCAAGGGAACCAGCCTCCAGCGAGTGACTCCAGCAAGCGCAGCCACCTCTGCCTTGAGTGTCCGGGAGCCTGGCCCCAGCAAGGGCCCTCCTGACCTCTGGCTCTAGTGAAGCTGAATGTCCTCACTTTGTGGGTCACATTCTCCATTTCCGTAAGGCCAATCTTGGCACACCTGGGGCTTACAGTGGCCCAGGTAATTTTTTGTTTCATGGACTATGGACTCTTTCAAAGGGATCTGATCCTTTTGAATTTTGCACAGCCCTAGATATAATCCCTTTTGATAAAAGGGTCTTTGCTTCTGATTACAGGAGCACTGTGGAACGTCTGTAAATGATGTTATTTTATAATTCCATGTATAGTTGGTGTACACTCAAATAAAAACCTGTCCCCGGCAGCCACTGCTCTCTGTATAGGGCCATAATGAAATTCTGAAGAAATCTTGGGGAGGGAAGGGGAGTTGGAACAAATGTCTGTTCGCTGGAGGCCAGTCTGGTGCTCAGACCTTTAGACTCATTGTAAGTGCCACTGCCAACATGAGACCAAAGTGTGTGACTTGTCAATGCAGCGCGACAGCATTAAAGACTGATGCTAAAC 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@rCer/356/0_1730_CCS AGAGCTGCGCAAAGCGGAAGACCCCAGTCCAGATCAGACTGACTCGCCAAACCATGAAACCCGGCCATCAGCATCGCCTCCTGCACATCTTGCAGCTCCCCGAGGGCAAGAAGGTGACCAGCCTAACGGCTGCCTAGTGACCAGAGCCTTCGTCTGACTGCCGCCATGAGAAAAATCCACCAGCTCACCCATCCAGTACGAGTTCAGCCTGACCCGTGAGACAAAGAAAGCACGTGCTCTTTGGCACCGTGGGGTGCCTGAGCACACATACCGCTCCCGAACCAACTTCACCAGCAAATACAACATGAAGGTCCTCTACTTATCCGCCTTCACAGCAAGGATGAGGGGACCTACACGTGTGCACTCCACCACTCTGGCCATTCCCCGCCCATCTCCCCCAGAACGTCACGTGCTCAGAGACAAACTGGTCAAGTGTGAGGGCATCAGCCTGCTGGCTCAGAACACCTCGTGGCTGCTTCTGCTCCTGCTCTCCCTCTCCCTTCTCCGGCCACGGATTTCATGTCCCTGTGACTGGTGGGGCCCATGGAGGAGATAGGAAGCCTCAAATTCCAGTGCAGAGATCCTACTTCTCTGAATCGCTGACCCCCTCCCACAGTCCCTCACACCTCGAGGAAAGTGGGGACCCCATCCCTCATCAGGAGTCCAGTGCTGCATGCGATTATCTACCACATCCCGCGGCACCTCACCCTCTCCACACACCTCTGGCGTCTTTTGTACTCTTTGTTCCAGAGCTGCTTCTGTCTGGTTATTTAGGGTTATCCTTCCTTTCTTTGAGAGTTCGTGAGAGGGAAGCCAAGATTGGGGACCTGATAGAGAGTGAGAGCATGTGAGGGGTATGGGATGGTGGGTACCAGCCACTGAGGTCATCCTTGCCCATTGGACCAGAGACCTGGGAGAGACTTGCATGAGGAGTGGTTGGGCTGTGCCTGAACCTAGCACGGACACAGTCTGTCCTGAGAGCACTCCTCAGCAGGCATGGCTGGTGCCTGAAGACCCAGATGTGAGGGCACCACCAAGAATTTGTGGCCTACCTTGTGAGGGAGAGAACTGAGCATCTCCAGCATCTCAGCCACAACCAAAAAAAAAAAAAATAAAAACAGCCCTCCTTACCACTGTGCAAGTTCCCCAAGGGCTTTGGGCATGAGCCGGTGAAGATGCAGGTTTGACCGGAAAGCAGCGCTAGTGGAGGGTTGGAGGAGGAAGTAAAGGATGAGGGTTCATCATCCTCCCTGCCTAAGGAAGCTAAAAGCATGGGCCTGCTGCCCCTCCCTGCCTCCACCCACAGTGAGAGGGCTACAGAGGAGGACAAGACCCTCTCAGGCTGTCCCAAGCTCCCAAGAGCTTCCAGAGCTCTGACCCACAGCCTCCAAGTCAGGTGGGTGGAGTCCCAGAGCTGCACAGAGTTTGGCCCAAGTTTCTAAGGAGGTACTTCTCCCCTCGCCCATTCAGTGCCAGCCCCTGCTGGCTGGTGCCTGAGCCCCTCAGACAGCCCTGCCCGCAGGCCTGCCTTCTCAGGACCTCTGTGGGGCCGAGGCAGGCCATGGAGTGAGACCCAGGAGCTGGACACTTCTCGGGAAATGGCTTTTCCCAACCCCCAGCCCCCGCCCGGTGGTTCTTCCTGTTCTGTGACTGTGCATAGTGCCACCACAGCTTATGGCATCTCATTGAGGAAAAAGAAAACTGCACAATAAAACCAAGCCTCTGGAATC 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S($%'#$($%"%'((%'()$&))))),'&),+(%#$$*),,'#)($(*&#&)(%&'#((+*.'''-*+&+',',--($---++)")$#$$'((+&"%'*--,++-(,%)'$*#)(&*$-)(')+%+&))#(*)-0,(($%0.--++,0)()0,*,&.1/-+-.*,*'(+&$'$+()',/)*&+**)*$(#%**/&)*.-)*&*-1)/'21,*-..+//.111-./+%/)+./,-./0.1*.+&+-0)-,.$)+($'%.&)-,(+/)*&.*--,,-%/+&$$*+&/+.-11,210,((+-*-&&'..+%+$)/,1-/%,-+)/(').-1&+//$##))1,,)+%(()..01201.1.%(0111.,+,0,+110,--(//-1),*21,'))-*&+-*-(2414*4-2-25.#'+0,2*$0#'0066.+01.403-/03*&%+./,/,)&.544)/&3434.2',+,*3324.(51055003-041.541**14126/(/)/2/420%%#+'30,#+2)022-&&.,03-/-(.31/4/)220%0.13565.0.&-1222061.1+4&1/45/501026652302/64453511455+302$+-00(3),/0+////,(&/46.3,/,124640)+'$0)2/643/,0*.)/(34450/.&.2.,/)/310..(*3,33613%.2-40.%1,),4$34%++*0)/60//)+'-/+,4-211.16/40*12$*.&01./325.41664045641-4./44.1-41.,//.#-,*145.62)32205+1*,%53//(,,13(-155452%)*&/%#/+)3&$*0+-*2314+2,'',110/3,31.-'+-0)+.2-&.0*++$+-1'+(&&$'*+./3,.(00-'$(%-)),+,+*2/$.+,$().'/4+(*./(/0)13.(./41(/.,)-03*+1/.+1'.*,+-+(/&'+)*/0-0,//+-+/30/13213.01453/20),0150043-41322%.2/*./../-%.,315132-$**(.12534/3.50/)+%&*((0*1/6221#*+$)&+1/4+*/13535411(/22-48:421*7+5:9)'.8764.138.524#564/01.//2212/04356641&01/.0,21'/-217325+2007'4/1-/+875(14&752458420:'037314&7960/508459*+$7,4124257579:99,/*'0207/5636006)0+./:55966/1%5/+944/-32&12-14/),63,737474:4*84*.-.0%01)-33/13%40-2'4/)2*1--3/36466,0.#/23,454.6:877)311445.95.+7533/45$,1,41/:945544&2/.5(3.6-7075175917955.60.654-7/527;448,/25%2(*04/54'84.629/9:3--4846'6727-560:2(3127*5%($1:287*,%)'%)0+,,-132$27:2,53:52%888.245,:48,659,99>>>/;??=8>65:>:%61.+%0-440.0/94*6:.=&990#8*.<9<67/(<7(%075'683.48<<88;>521::605-968249807409599449'4*)355'36'76.)3/(30583125+2316/03:)8947291-3+89586954.879242-'153792*44/5-3+,,+-0,1;3+7+'-.4:8*'.)9652104526795-4-67-7332525109683%.-.38 @rCer/357/25_1841_CCS ATGGGATGGCTGGAGTCTGCTGTTGTCAGAAGGCAGGGAGGGTGATGAAGGACTGACCCACATGGACTGGGATGTATGTCGGGTATGGGCATGACTGCACACTCACTCTCGGTGGGATCTGGGCAACATGGAGGAGTTTATGGTCCTGTTGCTTACTTACTGCAATGTCTTTGGCCCTCCTTTTCAACTGGTTCCTTTGTGGGCCCAAAGGTTGGGAGTAGGAGACAGTATCCCAGGCTGACAAGGCCTTGCCCTTTACCTTGGGCACCTTGTTAATTTTAGCCTGTGCCCTTCCCCACCTTTGCCTTCCCAGTGGTTGGTATGTGGGAAGCCCATCTCAGTTCTGTGACTTCATGTCTCAAACCAAGGATGAGCGTCTGGTCTCTGCTATGATGGTGGTATCTGAGGCCTTTCCCTGCCCAGTCTGGTGCCTGCCCCACATTGTACCAGACACTGGATTCCTGGATCCCCTTCTCCTTTCCTTTCTTTCCTTCGGGTCACGCAGCCCTGTACTGTATCCAGCACCACAGAAACCTCAGTGTTTTTCGTCTGCTGGTTTGGGCACAAGGAAGCCTTAGGGTATGGGGAAAGGCTGTTATTACTTAGAGTTTACTCCCAGGCCAGGGGGCTGCCATCTTTTTCACAGACATCCTGAAAGGAAGCCCCTTTGGGCAGGGAGCGAGGACTTCATCTCAACATAGGCTGGTGGTTGGTAGGGGAGCTTTTTCTTTTTTTCTTTTCTTTTCTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTAGGTAACATGTTAGGAGTTAATGTTGCAAAGAGTAGTTTACATCTTCACTTTCTGAAGACACTTGAATTTAGGACCGATGTATCTGTGACAAGCATGCCAGAAGTGGCAGGGGCCATCAGGGCTAACCACTTCACACCCACCATCCTCCCATGGGGATCCAAGACCTGAGATAAAGCAACAGCCTGCCCAGATCCTCTGTTCATCCTATCCCTTCCAAGGTTGGTCCATGCCAACATAACCTCTGGGCATCAGACATCAGCAGGTCTGTGTGCCTCAGCCCTGTTAAGGGGAAGGTTTCTCTTTCGCCCTCTTCCTGCACCTGGGAGCAAAGGCACTACCAGTAGAGAAGGGCCATCCAGCCCTGCCCCAGCCTGGACCCCTGGGGCTCAGATAGAGGTGCTGAGCCCCTATGTCAAAGTTGTTAAATGTTTTTGTTTTGTTCCATTGTAGCTCTTTTTTTTTTTTTTTTTTTCCCTTTCCTGGTGATTGATTTTACAAAAGAAAGTAAGCTGCTTAGAAGGCCCTGGAAGGAAGTGAGGAGGAGGGACAAGGAAGATGACTAGTTACGGAGGGTGAGGGTTGTTTTTTTGCCAAAAAAGCCTGGTAGAGTGATCTGAATTATCTGGCACCCTCCTGAATGGAACCCCAGAGTACCTCCTGTGTGGAAGGGTCCCTGGATTTTCCCTAACACCCACCCTCTCCCCTTCAGCCATGCTGATGGCAGAGAAGATAAGAACTTGGAGCCCATTTCTCACTGGAGAGGAAAACTTGTCATCTGGCTTTGCGGAGAAGGTTCCACCTTACGCTCGTAGTACATTATCTTTACTATGTGCTAGGATATCATATTTAAAAGGACAAAAAAAAATGTAAAATACTTGAATGAGCTTGTATTATAACATTAATATTATTGAGAGTATCTGCTTTCCAGGCTGAAGTGATTCATTCATTATTCTAGTCCTGCTTTAGTCCTTTGTAATTTGTGGTAATTATGCTTTTCTTTTTAATACAAAAAAATGTATAAAAATAAACACTTGAAAAG + ;A+EDE=@GAEDAA>CA=EGEFCDFFEDABF3EAC9FFCDBA>DD=D<@;B:DGEE>A>+EEC>=8EGBEFAAC?BF?FF;:?>C=;=C5G;'DD=CEB8EFDCFA<=8>?<@7>?ACF?5E;BGEC-FEE>C=E5G5CEFA@DCFCD69B>F7GB?5E1@CDD@FAC@C6B=E<6@CAC==AC=@E?1CGE:B9BBCD/E*D.?2FB8GG3CDB4C2A6EFCC=@=EF@F85%=AD8;4:@CFF>HG>C2GIFADI/@AA;I8E>II?ECIFH=IJ2IH>C>JJDAEGHIJ@E=FAH0JJJCDI@DIIEAJC=;7GF@DGFBFBJHHJII4IJE1B=GGJAIGBICGIE?IJ7IDIF/GHHGCIBD@H@JEHGCIH8CEA?5GGICIFJ?GE@6EHBFHH7DEE'DDG>?>?<9H;(DCFEG=H:EGIBDG?BD1EJDH;'DD@GFHECIDDJDBEH7(HCF>CGEF:F:;IGC7F?A4E@F.HHEDGA&AADABG?GA@-HHCGEBFIAEDI4FGI1I@E@?CBEADGCIGHFBI@IEEEJ0ACJ=E2IFF>IBIIIDIIBGEJ@JHFFIC.B?(BFC9EDG6G/$?ACB.EGCFD;G=GIDDGH?DGDB;BGFFEJBF:9@CIEG<&G>?=AEHHAGDGFDC9JHBJ>J9JGJHI5>9=IHGF8H5F9;@?IBE?HH@GJHFFC?HIEH6=:E;DD@GH7FDCHGHIJHDAEGI3DACBG?G7GFCFF?BGII)JDCEBG,FHIED:EC'E?A=IDGG>HGCDIHHJIII>@FIADBHJ@HAGCIHGCGF?E=GFJBIFHDAIH6GGHG)IIDED>GIIHACD>G?GD?D7?+EDGHHAHGIAFGG6GA:FAIIA@J<,C;)E+(A?DAIDEBDDDEFFEE0G=GCH>0AD=29:IE'?EBCGGHAH7GGBHHG>CB%H53>BEDIHD=DHBJ9EDFFE8HHA3JIH>FAC8HFEJ7G/IGJ;GIII>6HE;IHEIIH0DCJ,B?FFJIEGFBE8*FHH3=H=?DJGD?@:C:?6@FADFCBBCA@;FC1DC@HAJBG9GG@1FC=G<@E?>I?ACD:H5FB@I3IA>>CEGI>8HH?IIJFJ?H,IHHJJEFHIII>IIEF=H*CC3BDBCEE?HEEC;=AE(?B/ID>EGI=1D'5DFFCGICIHCI2IJGHD>F>HG?BBE9DGGC;HBAG5E:7HF;HFC?/;HEFAGE;C2AHIGDA>GCF9,<>E:EAFJACFFJA$HHEA @rCer/360/25_1681_CCS ATGGGAAAGAGAGAGGGCAGAGAAAGAGGCAGCAAGAGATTTGTCCTGAGGATCCAGAAACCCATGGTACCCTACTGAACACCAAATCCCCTGGAAGCCCACAGAGACAGAAACAGCAAGAGAAGCAGAGATAAATACACTCACGCCAGGAGCGCGCTCTCTCTCTCTCTCTCTCTCTCCCCTCCGCTTCCCTCCCTCTCTCTCTCTGCCTGTCCTAGTCCTCCAGTCCTCAAATTCCCAGTCCCCTGCACCCCTTCCTGGGACACTATGTTGTTCTCCGCCCTCCTGCTGGAGGTGATTTGGATCCTGGCTGCAGATGGGGGTCAACACTGGACATATGAGGGCCCACATGGTCAGGACCACTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGACTTGCCTGCTCTGCAGCCCACGGATATGACCAGCTGGCACCGAGCCTTTGGACCTGCATAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCCCGAAAATACGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGCCACAGTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTCAGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAATCAGCCATAAAGATCAGAAGACCTCGGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCCCACAGCTGGAGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTCTATAGAAGGTCCCAATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTTCTCCACGGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCCTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCAGCCAAGCGGGATCCTTGTACACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGACTGTGGTCTTCACCTCAGCACGAGCCACGACTGAGGCATAAATTCCTCTCAGATACCGTGGATGTGGATGACTTCCCCTAATGCCTATCGGGAAGCCTCTAAATGGGGTGTACGGTCTGGCCAGAAACACTGTAGAGTAGTAGGCAGATGTCCTCCTTCCCCTGGACATCTCCTACAGAGAGGAATGGACCCAGGCTGTCATTCGAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAAATGAGGAAATCCCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGATATATCCCAAAGTCCTCTACCCCCTTACTTTTATGGCCCTTTCCCTAGATATACTGCAGGATCTCTCCTTAGGATAAAGAGTTGTTGTTGAAGTTGTATATTTTTGATCAATATTT + DG)JJ*544)4++40;FBF;;=(06?66@9>>JBJC9EF?5;8DFDAH3HBE>J(E/<8IC:FE@8DGD>GF@>C==BBCD5EGHFG@CA7==0+:DC3>HJ<7J-?GB'HE7:,HFKIHJ>;J>=E>DGFABEK@A9GF,D%GHC>8%IIGEJHJ:JKE=K+G@*KHCKEIJBDE:CEFGECJEI2KIE=J:DHCEID@F?;A,FHFH7<>JH=ICCIJ>;51&BEEGJJ5EFKF3AJ=B'+(8DF/BH4AGAD=C5GFD>D>H@B8:37<95?'46C4C4D2D??95*:=DK;CIF3;:-EDBA:<31@FG?99GDB:;*:CB@;HIBDH?@J?AF;CADE=GFC@$FI>ECGA@@@@HDDCB$96DIHEEBE?J8@08FF@A=6D>A>GDCC8D?>>IHD?9>BIJDJH@DJD?HD6>ECH+K&GGE8*H<:BEGF:5F?>G;GKGI>93G=-E?J8DFJ2KF>8FAB'7C/KKJE.JFBDBCF1F,HB=8H@F/>?:A@AFGG:=H@K1C>KCJEGEHAC>4DKIED8JKCGK?1ABFF>A=EJJI+AAK>;??5;?KI8FFHJGGGADH4DJBJF9DEK@KKK=.KH:KDEJG7G@>I>9FKJ@JIKG=GIICF2I?BJKF:9@><9J.KK??HH9:E>7DDD:A35@>5E:8BGIFF>.+4A(:54?B>7@ED@B8;?:AFIH(IJH8GAD0F:HKJ5FAI;GIDEB609CB38HEB6@@,JHJJE7H,DBJ1FFA<>E:JD<GCIB?ADCE97AFHIK;JG@CJ>AI:5F7FC31A?HE?A=GG;7**>CA+CK@H47;<@DFDFI;AI):FHGHJ*BFF>H/G?>HIA5EBCEI9=IJ?JFAE@FF32$F=AB>=@AADF=B@DGA:@G>@+>AA=5=)3>>CB=3@92CGHH8ABCGFHI;HIAGDJE@.>?>@E:A??,CI9FDHFH3JI?BJF6FAEA6FH>(C?=HH:>BGJFED?G;I3=?9A*;8BC4==.HH@-CF>CA?+AA5@(9;>=?C:42CB4D?8=89<4@EDF=HFHE:GA=7C<>A@EI4GH=@EF6?46-BICB'@?:28B@@D;GEGI3AF$6?B?GD?9@@EBADDHD:</>?9CB+A52@A7FC98;8/7?:8>?CD:$,7+1@ @rCer/361/25_1632_CCS ATGGGAAAGGATACCCGGTCTCCGAAGTTCATGGCGACGCTGGTCCTAGTACCCGGACGAGTTATGCGGCCTCTGGGTGGCCAACTTTGGCGCTTCTTGCCTCGCGGACTCGAGCTTTGGGGCCCAGCCGAGGGGACTGCGAGAGTCTTGCTGAGGCAGCTCTGCTCGCGGCAAGCGGAGGTGTGGCGTGCCTCGGGGCTCCCTGGCTACTGCTTAGGAACCCGGCCCCTCAGCACGGCGAGGCCGCCACCCCCACCCCCGTGGTCGGAGAAGGGCCCCAGAGACTCCACGCGCCCTCGAAGCCCGGGCCTGTTTCCTGGAAGTCTTTAGCAATCACATTTGCTATTGGAGGAGCTTTATGGCTGGAATGAAGTACATGAAGAAAGAAAAGGCAGAGAAGTAGAGAAGGAACGGCAGCGACAGATCGGCAAGCCTTTACTTGGGGACCCTTTCCCTCACAACTCATACTGGGGAGCATAAAACTGACAAGGACTACTTGGGTCAGTGGTTATTGATTATTTTGGCTTCACTCATTGCCCTGATGTCTGTCCAGAAGAACTAGAGAAGATGATTCAAGTCGTGGATGAAATAGATAGCATTACAACTCTGCCAGATCTAACTCCACTTTCATCAGCATTGACCCAGAGAGGGACACAAAAGAAGCCATCGCAAAGTATGTGAAAGAATTTCTCCCAAACTGGTTGGCTTGACTGGCACGAGAGAAGAAGTCGATCAAGTGGCCAGAGCATACAGAGTGTATTACAGCCCTGGCCCCAAGGATGAAGATGAAGACTACATAGTGGATCACACAATAATAATGTACTTGGTTGGACCAGATGGTGAGTTCCTAGATTATTTTGGCCAGAACAAGAGGAAGGGAGAAATAGCTGCTTCAATTGTCGCACACATGAGGCCATACAGGAAAAAGAGCTAGCCAAAGCAGTGTTGCTGGATGCAGTATTCTCTTGCTAAGAGGAAGGAAACTTTGTCTCGCATAGGAGCTTATATAAATATAAACATATATACATGCAGTCTACAGAGTGGCCTTCATATCATGAGAACATTTCTGTTTTGGATGGGGATGTTACCTTGCGTTCAACCAAAATTGATTCTTGGAACTGTAAAGTTTACAACCCAAAGTCAGAGGACCAAGTTAAAGTGAAGCCAGTAAAGAACCCACCTGCGGAAAGGACACGGCGGGCGAGGCACAGCCAGTGCATTTCTGCCTGCAAACAGGCCCTTCCAGCAGCTTTCCTGCCTCTCCATTGTCTTGGACCCTTGCTCAAAGAGCTGTGGGACTGAATTTCATGGAAAGAATATGATTTTCGTAGTGCTCCTGCTTGCCTCTTCTTGAGTTCTCTGTTCTTCTGAGTTCTTGGTGGCTAATAACAGATTAGGGTCTCTGCCATTCAGAGTTGATACTTGAAAACTTTAGTTTTCCTTATTAATGAATATCACTATCGGATTTGACTAATGAAGAGGAAATCTATCGTTTGGGGGAAAGAAAAACATCAGTTTGATGTCTCTAGGGGGTCTTTTGTGTGATTTTTAGCTAAGTGGTGTGCCAGGGTTTCAGTGACATACCAAATGAAAATAAAGAGGATATT + GI%J;.KK0C41B@GK1KHCHIIKK@?GFKEGGHKGKKG@K;JDHJ&DDJ>KDKDKKCKKDGKJG>KDJIEDKKKKKGKIKKKKKKJ@KK5KHKEKKKJKKKG(IKIJIJKKKKKJJGKGKKKGJHGKKIJJJKJKKIJJFHKKIKKKKKK>KFKHHKIJJJ@KKK6KKKEKJKKKK,KKIIDCJF7KK?KK@K@I9KKAJH&@EK$KIGFCKH'EF>JKKJKKBIHIKKKIJK8KKF>JHBF%KIJHJJIKJIBKKC0KKJIBIJ.KKGB;G8KJKAGKKIKCKKKK>KKKGJDB?IHKKKHH+KKKHKKK5KKKKKKEK:KK?KKKKJIKJIKKKJKKDKJEKICKKKJKJKKK.K=KKJJKJJCGKKKIKHKJ?IKHKKKIKKK?K?KKKGKHKKKKJKKK>KJKJKJFKKJIJJKFKKJKKKCI=KE?KIFK=JHKKCKKKKKJKKJK@JJKKKGIJJFKJKFGHI0JD&JKJHKFK62?K=1G8ICKJK6KKHK>KKKKKKKKJJKFDK6KKKKKKIEFBFHKJAK@KKJKKHKEHKKBHJF9JGJKI<;GF>BD>8:EEKFFKKKKKKKK3IKKKEK>KJKIKKKFKGJKEJ3KJJ*KKKKK6KKKHKKK*KKKI8JDCG-I:DIKKFKKFFHK>KKKGKKKKKK9KCJJKKK8BDKKJ'KIKJHK1KK=KKKKKHKG@KKFKFKKDK*KJJJIEKKJKKKICKKJEKIKKKGJEJKJKDJI?KIEIGFJI&JKKKI2KKEBHGDKHKJKKGDKKKKJ;CKKK5KKKKFKKJ5KK6KKKDKKKHJBJK@KEKKJK9KKKJAFKKDJKJIG8K @rCer/362/1834_58_CCS ATGGGCCGCTCGACTCGGAGGCTCCCGCAGCCCGGCGTCCGCCCCGCTGCCCCTCCCCGGGGCCATGGGGCGCCCCGGGCTACCGGCCCTCGGCTTGGGTGCATCTCCTCCACCAGCTGCCCGCGCCGACTTCCAGCTCCGCCGGTGCCCAGCGGTTTCGCGCCCAAGAGCAGGAATACCAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGCCTGGCTTGGCCTGAGCCTCATTTTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCGAGCCTCCCGGTCCAAGACCCCTCGCCCGGAGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCCGGCTGCATTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCCCAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCGCCATTGACCACCTGGTGTTGGAGACGGTGGAGAGGCTGGGTGAGGCAGTGAGGACAGAGCTGACCACCCTGGAGGAGGTGCTCGAGCCTCGCACAGAGCTGGTGGCTGCTGCCCGAGGGGCTCGGCGGCAGGCAGAGGCGGTGGCCCAGCAGCTACAGGGGCTGGCCTTCTGGCAGGGAGTGCCCTGAGCCCCCTGCAGGTGGCTGAAGATGTGTCCTTCGTGAGGAATACAGGTGGCTGGCCTATGTCTCTTGCTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCCTCCTGGGCCTGGCGAAGCAGAGCAAGTGGCTGGTGATCGTGATGACGGTCATGAGTCTCCTGGTTCTTGTCCTGAGCTGGGCTCCATGGGCCTGGAGCAGCCACGGCTGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCTTATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTATTTCCTCTGCAACCAGGCCGTCTCCAACCCTTCCAACAGAGGCTGACTCTGTCCCAGCGAGCTCTGGCAACATCCACTCCCAGCTGCTGGGCCTGGAGAGAGAAGCTGTGCCTCAGTTCCCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAACTTTCACCAGTTGGTGGCACTGCTGCACTGCCGTGGCCTGCACAAGGACTACGGCGCAGCCCTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTGCTCTTCTCCCTGCTGTCCGCGGAGCACTGGCCACCGCGCTCTGCAGCCTGCCCCGCGCCTGGCCCTCTTCCACCCAGTGACGACTACGATGACACAGACGATGACGACCCTTTCAACCCGCAGGAATCCAAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGAGCCCCTCCTCCCTGCCGGACTGGACCCTGGCTCCCTCTTCGTTCCTTCCCTGGCTGCCGGAGGAGACCCACTAACCCAGCCTGCCTGGGCTCTGACCACTAACACTCTTGGCCACGGACAGCCGCACAGGACCGCCTCCCTGTCCTTGCCTTGGGAGTAGCTGAGGGGCAGACTAGGGAGTAGGGCTGGCAGGGGAGGGGGCAGACAGCCTCACACCCTTCATCCCTGCTGCCGGTCCCATCCTTGGAGGACTGAGCTGGGGCGGGGACATGAGTCCCCTGCTGCCCCTGCCACATCCCAGTGGGCTCTGACCCCCTGATCTCAACTCGTGGCACTAACTTGGAAAAGGGTTGATTGAAAATAAAAGGGAAGACTATTTT + JKKJ&<@KJKKKJKC#9JEKKK8CKIKK;EK+KJKKK3?5KJKI'KKKKDKK?HKKAKK#JBKKKKJKCKKKKK;KEKKKBKEK?JKJKKKKGJK@KK(K?KHK.DK4>.JK$KKJK'DAKKKKK6KKGKKK8KJKKKJKKKKKCJ;KIGKKKKKKC=JKJFJBJIK)J?IKKK2KKHK-HKJ?I&KKKAKKKKKKKKIJKKI3KKKJ>KKKKJK?KKKKKIJKIJKKJKKKDFDDK;KKJKKFKKEGKKKKKKKK9KKKKKJJKJKJKKFKKIGKKKKKKK?KKKKK.KKKK@KKEKKK1KKKJK+KKAKKEKKBKKJJFJHKKKKKK(KKKJK1KFJKK=KKKKEJI8GJHJK?JH&IHKIK7KCJKB&=FJAKKKIJKKHKK>JKHGKJKKGKKIFI0FDKDIJFJ4HDFFKKIIKKJHKK:KKFG5GJ*JIKJKHKAKGKKKK-CK;KKKK2K(II)K3AKK)JKIKFKK7HKE*HKK*KKK7JJIKK>G1EKIKGJKH)?GKKKKJEJ6JK2KKJ6KK@I>KK&1;KJK&IKKKK(KKKKKJGKFKJK@KKK6KGKKKKK9G%JKKK>J-KKK=KKKKKJK?KI3EIJKJIKKKKI'8EGJ-JJI>IJJKKKK&HKJK@KKK.KKKHJKJFCK3KKKKK)JKKFKJKKKK)KKKGIJKKCKKIKJI7KKKKKIDKEKHKKKHIG&KIKJGEIKKKAKKKKGKK@KAJJGAKHKK: @rCer/363/1798_57_CCS ATGGGAAGCAGTGGTAAGTAGTTTAAATAAAATAAATGATTTCGACTCATTAGATTATGATAACCATACTAACCAAAATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTT + .$-20,,.))(-.--0/0.,.20120+&,+(*+++,0),./'0/-+%*-,'-0.-,/*-0120/./'-)+00.)"#((EG@G:4@<<@8<3;C@><.CB7>AEDB=;ACBDAA?:;5??BAEA@=>49D=A81;B?D6>8>/CBEBC@E>;4??DCD>@9;?A;B9>@@6FF@BEBAD8DCA@?=?4>A>;AD=DFB??B7C@E@@77>@ABBB4>:6C=>6=A:AG?EC>E==A:BD6DDECDGEDDD?DBD<5=@95CB@8AADEG9@8/87=9C<@66ABB:>@FAC9EAEE>ECFA=>BCAA2@<<>4:A?>B@C>@<;E1>CBFA3BE4@B/EADD3@??0?;A?C1B=A>9D@A:8DC@=BE@C8=)==3@4;>4==68B+@D>??%B;?@@?A;DEBBE?DA=AC23<19C=CB@A?@DE:BEAC9C@@?:B@79:@?DC:@B>AA53A=@C=D>>ADA>;>4><4??A38?AA=E8>A@)ACA/>?=?C9=DE>9FE79>958B2E?B09;=C9EA889CAD?@8@>B:6@>6:29?-<69:<;9><>949=>D6>A8BDAD@872@;>:14'68F>A>4/=@?@;?@6;:>>:-BC@>AB3>CBEAB:<@<9EEBE?==AE;DD:BEEDABB@E6>>B?8A5=6DF@6@?7@AB49?F;B?BDBACDE@8F@A1@?;;<7;BF@CG?B@>EE2@AD=EAE42>?*GCC>B@;G7A43?/AADD;=>E7DCF8?A=3A@@>>>@+D<E2@CAA@C?A80<0>CAC<'AAEAADA>>B.DD9?<5=,7=DEE?E>:ACABEBEG;CFB@=DD@?E:@@B8?=-0?9>;/9=;3*>;6;;9842%21:669:=45-=;9'96.;:;?8;6>=>:==296<600:991?7545;<1=3<8:;79:=;.98<3<;;%0635<:/<:;3696/77.;<:::<;<;;:=>=76718+99?===:7;5>2==886>:1<07<9=:<><>9?<=:<8024=5=/0<;>=6=?=:-498<8?6<13>>:67:9<=:(884<=;;;?6=;;>;=9>><98/;7?>;88>6-;2:8:-46272:==::;37;7:=8>90+=?07;,547=;35<8558>:?;5;67687-<9::76>:?73<==<<<7<909?>;9>:559;=%%1585%>6<<9/<92;>>=0699>7:>6947+>9668<<5:=::7:5?77<:>=><=;=9>:78.7<48==6<%8<98(:?><>=2;==0>;:6 @rCer/366/24_4389_CCS ATGGGGCAGTGGTACATGGAGGACCTGGGCTGGCGGGCGTCCTTACTGCGCGGATCATGTTGCGGCTGAAGTCACGAACCGAGACCTAACTGGGTGTCCGACCTGCATACTGCAGTAGAAGACCTGGGTGACCATCAATACCCTGTGAATCGCGCACTCCTGAAACCATGCACGGAGACCTGGCTGGGTATCACTACCCTGCTTATTTTAATTGCCCTGCTGACAGCTGCGGAGGACCTTGGTGGGCATCAGTCCCCCGCGGATCATGGGGATGCTGAAGCTGCGCACTGAGACCTAGCTGTGTATCTCCCCTGCGGAAGGCTGCGGAGGACTTGGGTGGGCGTCGATACCCTGAGGATTGTGGCACTCCTTCCGCAGTCTGCTGCTCTAGGCTGTGGAGGACCCGGGTGGACGTCAATACCCTGAAGATGCGGTTACTCCTTCCGCAGTCCCCTGCTCTAGGCTGCGGAGGACCTGGGTGGGCGCCAATACCTGCAGATCGCGGGATGGCTGAAGCCGCGCGCTGAGACCTAGCTGGTATCTTCCCTGCGGAACGCTGCGGAAGACCTGGGTGAGCGTCAATACCCTGAGATTGTGGCACTTCTGCAGCAGCGCAGAGGACCTAGCTGGATGTCCTCCCCTGCAGAAGATGCGGAGGACCAGGGTGGCCGTCAGTACCCTGCGCGTCACGGGGATGCTGAAGGCCGAGCACTGAGACCTAGCTGGGTGTTCCTACCCTGTGGAAGCCTGCGGAGGACCCGGGCGGGCGTCAGTTACCCTGTGGATTGCGGCAGTCCTGCAGCTGTGCAGGGAACCTAAACTGGGTGTCTCCCTTGCAGAAGGCTGTGGGGGACCCGGCGGTGGTCAGTACCTGTAGACTGCGGCACTTCTGCACTTGCGCACTGAGACCTAGCTGTGTCTTCCCTCGGGACGACTGCGGGGATCTGGGGCGAACGTTGTTACTTGTGGATCCCGGGATACTGAAGCAGCTCACTGAGACCTAACTATGCGTCCTCCCTGTGGAAGGCTGCGGAGAAGCGGATGGGCGTCAGTAGCTTGTGCATTGCGGCACTCCTGCAGCTGCCCGCTAGAGACCTGATGTCTCCTCTGCGGAAGGCTGCGGAGAACTCTGGAGGGCGTCAGTAGCCTGCAGATTGCGGCACTACTGCAGCTGCGCAGACACCTCGCTGGGTGTCTCCGCTGCGCCATGCTGCGGTATACTGCGGCAGATTCCGGAGAGCGTCAGTACCCTGCGGATTGCGGCACTCCTGCAGCTGTGCAGAGACCTAGCTGGGTGTCTCCCCTGCCCAAGGCTGTGGAGGATCACGGAGGGCGTCAGTACCTTGCGGATTGCGGATTGCGGATTGCGGCACTCCTGCAGCTGCGCACTGAGACCTAGCTGAGTGTCTTACCCTGCGATGGCGATGGAGAACCCTGGTGGGCGTCTTTACCCTGTGAATGGCCTAGCGCTGCTGAAGCTCCGCACTGAGACCTAGCTAGGTGTCCTTCCCTGTGCACAGCTGCGGAGGATCTGGGCCGGTGTCGTTACTTTGTTGATCGCGGGAATGCTGCTGCTGCGCACTGAGACCTAAGCTGGGTGTTCTCCTCTATGAGCGGCTGCAGAGGATATGGGCGGGCGTCATCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCTTCCCCTGCGAAGGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCTGCTGCGCACTGAGACCTAGCTGCGTGTTCTCCTCTATGACGGCTGCAGAGGATATGGGCGGGCGTCAGCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCTTCCCCTGCGGAGGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCTGCTGCGCACTGAGACCTAGCTGCGTGTTCTCCTCTATGAGCGGCTGCAGAGGATATGGGCGGGCGTCAGCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCGTCCCCTGCGGAGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCAGCTGCGCACTTAGACCTAGCTGGTGTCTTCCTCTGCGGACGGCTGATAAGAGGATGAGGAGGGAGGAGCATCGTTACTTTGTGCATAGCGGGGATGCTGAAGCCATGCACTGAGACCTAACGGGTGTCCCCACCCAGTGGACGGCTGTGGAGAACCCGGGCGGCGTTATTATATTGCGGATGCTGGTGCTGTGGACGCTGTGCACTGAGACCGTAGCTGTCCTGCCCTGCGGATGGCAGCGAAAACCTGGGGGCGTTTTTAGCCTACGGATCGCCTGTGCTGTTGAAGCCGCGCTCAAAGACCTAGCTGAGTGTCCTCCCCTGCGGAAGCCTGCAGAGGACCTGGCGGACTCTTTACACTGTGGATTACGACGTTGCTGAAGCCGCGCACGGATACCTAGCTGGTGTGTTCCCTGTGGTAGACTACGGAGGATCTGGGTGGCTCTGGAGGTCGCAGGAATGCGAAGCCTCGCGCTGAGATCTAGCTGAGTGTCCTTCTCTGTGGATGGCTGTGGAGACCTGGGCGGGCTTTTTACCCCACTGATCTCAGCGCTGCTAAGCCCTGCACTGAGACCTAGCTGAGCGTTCCCTACCCTGCAGATAGCTGCCGAGGAGCCCGGCAGGCGCCCTTACCCTGCGGATTGCCTGGTGCTGCTGAAGCCGGCGCTGAGAGCTACCTGGGTGACACTACCCTGCAGTTGGCTGCGGAGGACCTGGTGAGCGTCTTTACCCTGCGGACTGCGACAAGGGTGCGATTGCATATGTTGGTGGGCATCTTTATCCTTCATACGGCGGCTATTCTGCAGCTGCTTATTGAAGACATGAGCTGGCATCTTCCCGTAGGACTGTGGCACGTCTGTAGCCACGCACCAAGGACCTGGGTAGGCGTCATGACCCTGGGAGCAGCGGCACAGCTGCGACTGCGTATGGAGGACCCAGGCAGGCTCCTTACTCTGTGGACTGCAGCGCGGCTGTGGTTGTGCACCAAGGACCCACCTAGATAGGCATTCTTATGAGACAGCAGTTCAGCGGCGACGACTGGGTACCAAGGACCGGCGCGATGTTCTTACCCTGTGGACTGAGGCACACCTGGGGCTGTGCACCCCAAGATCCAGCTGAGCATTCTTATCCTGTCACCTGTGGCACATCTGTGGCCAGGAGTTTTTATCCTGTGGACAGCAGCACAGCTGTGGCTGCACACTAGGGACCCAGTCGGGCGTTCTTACTTCGTAGACCGTGGCAGGGCGGTGGCGGGGCACCCACGATGCAGGCGAGTGTATTACCCTGCGAATGGCAACACAGGCTGCGCAGCCAGGACTCAGGCGGGAGTCCTTACTCTGGGGAGTGCTTACCCACGGACTGGGGCACAGCTATGGCTGGCACAAGAATCCAGGTGGGTGTTCTTACCCTGCAGACAGTGGCAGGGCTCTCATGGAGGGCTCGGGTGAGCGGTCTCCTCCTGTGGGTCGTGTTACTGTTGCGTCTGTGCACTCAGGACCTGGTGGTTGGGGTGTTCCTCTTCTGCTGATTGTGACACAGTGCCAGCTGCATGGAGGACCAGGGCGGATGTGTTTACTTTGTCAACTACAGCACTGCTGCAGCAGTGCACGAGAACCAACTGGAGCCGGATAGAGGAGGTCCCTTCCCTTCTGACTGCAAACAGCTCCACCTGCACCTTGAAGACCTGGTGAGCATCTTTGCCCTGCCCTGTGCCATTGTTCTGGCCATACACCAACCTGGACAGGTTTCACACCTCTATGCTGGATGGGCTGGCTCAGCTGATTGTGCACTGTGAGGTGCTGCAGGAGGGGCTTCAAGGACACATTCTTCTTGACTTCTCAGCATAGGAGTGTCTTACATCCAGTCCACGTCCCTGTCCTAGTCCTCTCTCTGCTCCTTCCACACTTCCTCACGGTGGTCTCCTGCACGCTCGTGGCTGTCAGTACCAGATGAGGGCAACTTCTGCATTTTCTCAATTTCAAGCACTCCTCTCCACTTACCTACCTAGTATCTCTACTGGGTGTCTTCCAGTCATCCTGCACTCAACGTGACTGATGGTTTACTCCCAACCTGCTCTGCAGTTTCCCTGACTTTGATGATGGCAACTTCATCCTTCCAGTTTGCTTAAGCAGATACCGTGGAGTCATTCTTTACATTCTGTTCAACTTCATACCTATTCCTCAAGAATTCTGTTTTCTCTATCTCTAAATGTGTTTAGAAG + 0*$,++.,*(0.0.11.,-0-21121&,*+.,1+'0,-11)-.2-.,,.,1,2&*--0.02.102***'/-11.11+,',)&*&*0.,1./$,+'$&$0-,%(*++00)(%**'/,--*,,-+/-)*')&+,'#*,**),)0,,1)++(&$,**---0+21*%)*+**&(&(()&*,+++1)0/+*(00,,1.'.1(.+-0/12,'-&%''%+.&.//).&-+1-+)&+.(+-,0110'+))&#%"&'+,,*-,-11.+0'&%0.-/'...00(1),'0+-.)--101-010.0.1011.1(0111.0-020--++102+0)+-/,,,,,,,((#&%*),++)(-.(.*%--%)%&+1-+),*10-11--)*&(,--'(,11/'/,000/*('*)*$*)--+(.+#&$'&*+,,%&,.(0-1-0*'0-'$-.)+$#'+)*1+.0201010'-&(-%(*,+0100*+/,.-(,,/21',(#%,.,,-/'--0%)(,(&)),*)'"&&'+$(,,+-/-(,*011,-//,)())+,')&'&(+(&,+++*-,))-,/111111.1.2/+/0102+.1-,.1/+(0,01..1+)%&$"%*+*1,./0,-*()*,'($*)'()##&')(**%&)*,,)"$*)**.1111/&).-/$&-,+'$)+).*$(&'*)'++**,*('()+&+-0,(($-,$'-*(&&''(*.$('&%")1,+.3/0.+01)-),*(&&+***/,.&#',-)*)/+'$+'$',/-%).%+)$($'%%))$'+)&#(,-2/(.10*40100#)-)3,.1+,2.3010+/14/,1%$+2+&.00/%*(,(&-))0*+1/-,),0*-.***&'),,+**'$,+(***..)-)0-%0*..44/.-05/,,/),/0,//0.&33,0-..10,)%)*./5114/21213(-*,3*1.)0)%%(1,"*$'//..#*()+++.+0((&,+--#%*'--.,'-/'$(-+.2-*&..,,)%(//11--)()/,'//*-01/--*/-$0001,*-)/-20/024333162#'.16$/17)-3:55)2736776668545'04203)2403/3-/2&0135'%31,340-,-%.//447.31552:.98:98746:9,3;9166276199068::4,68175:96-1/673+56799..2./4766666:82679/835:761694+83453:88::926.22696:7:.550*26400030*24/430782289.5)885,2)2680283556373755/9,14:575.97832481)65-460-4846559.97759&8-(6,99633359.6-46'7517.4:5244334036/822(12/898.77299:484376:2970432632993780344.849413011014:94.7944.432//32454//858:87245,9.894333'473.33'335/731101.8748064868:5444541:(125434549::419:856994672495714*8769032+032*.5614)3859.4'8426,61--,(-15300//2756932)3;97/42524411053003152,.00*52%3&*210634.4-'+310-23268:/74531,5:,1-593.:76)83,-5:80124,52.--1,/355,4114653.59945128/65335462(+-688-+:5547*6-7631793-7%+,.2,-463:5524'%-44,4:812064748177.%-1/,2695.347-678::..4.2+699:6::8/164.8:::98.-/9157:94/23/.%-+0573$$,+,381+)/.1/0854/110.-314834.333240&014'1-/,38851048672117334-,(2152-.22./37,8798:7,5/'52789:7:,75929212/1&/,.3..1.5482)8784255744.(10/03.%03/*+0/2,/424/079'1523/2-,02-053&26345143701-275:687:305531#0/()4833882/6/9-8371665&5:5/353097-065*501/)*+./,0.15'-/742,095:3343,45536:23/%0-/,..45366'/.',(0%++47(../3-3+34312066/2307532*,-)264).-/595750070/20,3/3/-0,,&',5+2-/%(/04/2262,+#(&)-+*((*0--4349/2&&0$157573'1.(+3242'5-59659962940**,'/%+.476641793-,0.33/+225923;771.8886875/0'/7334223%/2,-("(%,(-41+2&-4-.,02423530+,)25350314&/5-+,(0/**+03*/-/,,#)--/-'%(,-%%%'+%+)+-/*/1/+/-''&%$.(&-)2571289.1(702/'&,0504/0-5+0-.0/267583/-6.7658)0*1.*4(/1+,2%,24,134&(((,/.*335.35562/&-+(+.3/(+,1.-32.4*/,3.2/1+(.1-1050(05(1214:2/3/23787455:492/681437%6,..,/3.543952623424568483.44433/15416/884.+.)2,0.$*3466...&(3/-3.5896592433/709:734/.-300:'10/4'141211&..372-*3$20571202,142&2./62-23.0+.*)14:9776732343(59,6643360++22,-1115371,0-0+123699-3.5:79:234955822434770+:81343-3363)8+70-23+./-/1-1121256.41.0()$'///616/,1+10*/13.10/20234.314414*0,,0264/4+2/$-5,0'.20(34+/.,02422.'310)455650612664665121640+3642530*.+--*2.,2'11/-*2+054-+/0554224261-3502).+032//-343'&1154.2-'2((150)2'21//.%.'33410%.,/02-.34253141/3411645,31,325)5.5/.+4554*.-5/236410430)/02145*0364514/0.51/450211/.((04/640564*255,555233403331/.,25-36202104465/25.5165,42,15(/(02&10/+.4/103/$-22*1*)2*-+/%/666445*24156563565.44/&',00,1+4)0--2465045335(5146.436561/43256616015526.*55555323/10213'4.45+0.013-20/53551254.30/+/1)0025430/34/5-.,164644624,456134,4535-11/550'436641).+**3..2524-45/(540.5344661225525536140364*//0/60./1162555/4+*2/0536/4.64'2020435065-/.5651064'3.,$26533.65054144'0//24120-.25160-3--)14&4,)150213-.04.%244,%.03263'252.'5434(555035135/1/+251-11//)22'33350121../-/+55+3)061054551001++.2/(30+##)./-,.,-26*0+-5455512).,+,06+26655*5.-*004.1424011.,),123,/15--,1-32+2*.3-)3-1'32*-0+1251,.54/23254,2313//10+1.1(5....1/0404516/'--+354-663551.0331.44535.0/.4-2500325413*05665.441,-342455/#$306.5060-11)-.461+12)54)2*42.4(/421345&0#++)./263235211,0124'/.,)/2%2'.2215+21444*4./0165/-5326556.)40./5550,)--+3/4*20*5303260650425564663/0/+$+,,-1155//#-55610/5043.2443351/4041464033.4*-5655155.526-410./63034/340336515643164+*)'4100+.114446513045524%2*.1/,3445-26/%250-122/26665350-1-5356635-1//2+004643354.55625.34*/13634221.*0..-&210*4406444.3*35540456/452155563146136364)/54-02..6)'1120./-.133&120456345651415/466435043,45414525465+4366001+552631144./14636+66+23211233533365*26456515355+2.6-441%125633560*34,533646133/.*/153/60'#%**,,22551555563)./0/2363551+0536.3220.0344/4655214'$,/.-11,221,'01 @rCer/367/25_1817_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCAC + @C0DED?@C@CE@E==:C5CC=@GE(ADBC;C;C9DF?D;7CBFFGGECCCDBF@9E=BAAGF9<@@D@C2?>CGFCGEGEBCE<=86BE?C>?:7BBDEDE;C>;DF3-9A9;D3BFE=9C=;CD169>7::;087:<>=DDDF:CC7ACA>A&?CD@D@?@4A?EFGBCEIGHG?IHIGHF<9B@84DII6HGFE9ABBDDFCI6HDE6FGFJHFHJEHFIGAEGIKIIHEK@DBGGGJ@KHBIJ7JI??@EHGFEHI@EFEG>I=GG@IIFC5CBEHE?F9G?J8JEKIE;BGGJHEJHF7IKKICBI9?@=HJIJFGCHDCC:?=D6AEG=>GFEGJCED@FCGF6@FEH?BCFIH>EBE7@9=::?EEI??>DDHGEE7:A@CDH;KIKJ?E9GFJIIDD;AD>EGE:DCCGHFF=@6BGGIFC:HFJB:JHKBCJIEJIJ;IKKIGJKAKKKEFI=IGCKJJKJIKKHJKJGKJKGJBI?EEF>HG:HHAE@KIJHJJJKKKIJKKJHJGKHGKGJIKKIHDIKH0KJJIKKCKHJKKHKJIJKHKJGKKEJF>3AIGIJGKGKIKHIIJDKIJ7CCEH4IKCFBIIKKJKIJEIJJJICJGIIHJIKEKJJJJJKJGKK:JKKHKJHKKJCJIJBKGJEGFEHC@IDIHKJ@JDKKJFKHKKKJJKCKFJKFAKDDIFKIFKGI3@JIJ0JGKJKHJJKIKIJHKIIIJJDJJKDIEK?KJKIKKKKGKKJKIIJK=FHJFIJEICKKKJKKJJJKIJJJ23GKJIBKJKKJIGKKJIKHHK?EIIF?KKIHJHKF.@HJKKH@FJKJJJJCJKJKJHKHJEJJKJIKKJ;K9K?HKD?JK=EFDJIKHKJC5JK>KIBKJIHJJ5JJKJHKJEKKJKK@JIKAJJKJAK;EIIJKEKGGJ:KKEJJE8JEGDJICJJJKJJCFHJKGJEFBJKIKGJCFJ?JI;IG*H>EB@BB3< @rCer/368/1533_55_CCS GGGATCCAAACTTATTCGAAAAGCTAAAGAGGCACCATTCGTACCTATTGAATGGCAGGTTTTGCAGCAATTGTTGCATATGGATTATACAAACTGAAGAGCAGGGGAATACTAAATATCCCTTCATCTGATCCACATGCGTGTGGCAGCCCAAGGCTTTGTTGTAGGAGCAATGACTATTGGTATGGGCTATTTCATGTATCGGAATTCTGGGCAAACCTAAGCCTTAGAAGAAGAGATGCTGTCTTGTCTTGTTGGAGGAACTTGCTTTAGTTAGATGTCTCATTATTGAAGTTACCTATTATTGTTGAAAATAAACTAATTTGTATGGATTTAGATGGTAACATGGCATTTTGAATATTGGCTTCCTTTCTTACAGGCTTGATTTGCTGTGACCGAATTACTAGTGAAGTTTACTAACTAGGTCATTCAAGGAAGTCAAGTTAACTTAACCTGTCACCTAAATGTACTTGATAGTGTTGAAATGTCCACTTCTTAATTTTTAAGATGAACTTAGTTCTAAAGAAGATAACAGGCCAGTCCTGAAGGTACTCCCGTCCCAGTTTGCTGCAGAATCTCGTATTTTGGATGTTGTATAAGAGTCCTATTTGCCCCAGTTAATTCAACTTTTTTCTTTTTTTTCTTTTTTTTTTTTTTTTTGAGAAGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCGGTTCACGCCATTCTCCTGCTCAGCCTCCGAGTACTTGGGACTACAGGCGCCCACAACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGTTTCACCGTGGTCTCGATCTCCTGACCTTGTGATCCGCCGCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCGGCCAATTCAACTTTTTCTACCTATTTTATGGACTGTCTGCTCTGTTAGAACTCTGTCCAAAAAGTGCATGGAATATAATTTGTAAAGCTTCCCACAGCTGACAATATATGTGCATGTGTTTAAACCAAATCCAGAGCTTACAATAGAACTGCATAATAGTAGTATTTATTAAAGAATCACAATGTAAACATGAGAATAACTTAAGGATTCTAGTTTCGTTTTTTGTAATTGCAAATTATATTTTTGCTGCTGATATAATAATTTTAAATGTCATCTTGAAATAGAAATATGTATTTTAAGCACTCATGCAAAGGTAAATGAACACTTTTTAAACGTGTGTGTTGCTTATTTTTTCCATAAGAATTGTAAACATTGAACTGAACAAATTACCTGTAATGGATTTGATTAATGACTTATGAGCAAGCTGGTTGGCCAGACAGTATCCCAAACTTTTATGTATTACAGAAGGCTATTACACTTGTGAAATTCTCTTGTCTAATCTAAATTTACATTCATGGCGATAACATGGCATATGTATTGTTATTAAAGTAAGTGACCAT + +,)')-*($%))*,.)1/111+/+%',*0-0-0.0*$/)+//,*++)-)#.00+,1)*'200,.1+/-+).#',)+/11++)%#++)351/0---/.+53-441/(%/%0*5686+3)113&7-.75097439.888724/.02:27-/.3(8-1286:.44'/275798:0/2251..5-3%2:8;;36.868(23434-(22),+0.,/15'/33$''6:/3:13-..91$2+/*52),,**-%3*&+)-+/10/%,0*06.3-9744(*.61.-0712*+/45685(37528-84,84-*22123*3-01$,33'+5826:.68::97216&3/42-#*4+0-'0%.-/47&66+330571.0&7/70/.5-+,/4.04.8../&-%($*)-0)64)5%0*%&'*1$%*/.%-+*0..(/6375==2=9(;9@79=?C<:@;;(7<0A+><@::(:@.:;<.>>7;;//54:;2/2@2-15,38<4+0-8;973?07=?@-0)>986C;<9859?1/870&6<0,+5B9@6>9:58?:87==:'6->4,,40"#(;9&78>C<@?<:<=:40<372>0.20:)749<98/0761,19:57;1*2)0%,857&83,-7/<8+A4::BBA=-+BABC8@<;#;39;1;0@9975;48458;;8@><*21%;792-387<7<8:-*4348624;9.+5.0205555?8=;2<:,38//'<997:;A59=6969222%93/2<.21%:;09@8:,8:%65579;;'96?@3>=;-6.<:89:&:8:<<03<94/(53<8<<7%/>=68.6/5:<$9@-:%9::3@93761&3>?51:-<<68*:9.1'64.2+$&($0#,)1)20=+6;4686.-'082,+06168%1778<0.1,7:13+78937888+;6>;>><.=;>8-699972)#2%)0/4/67-)/::1.37079':=7=:3=<:-00801)0+/89:6;8653<=88(01/52/0)$.-/*7033.,/4+478476747464.::235.5728<4:7553596-'+-6:61274/77-.2(5<0616*90/555898,1236:<2(3/:77(<483&90/-65567%988<6424+/04*/3(+22#,5.6..14#3947<9/16848*13609<<9;-9(57765<698217/3.3::&88<-50.017/#31*5-%&,)(.5&2.-/275343/-&.-5062)3/34,3+333037.5677180/'2+-4,.*25225350.+-3527.11/01--/81857-7.,(%4%%%.&57452.,-$&/(2220245&54512/+22548562128:109565&).,/:/:9224:8245/-,+32:;4;;73+.(%$(,6-2)1.:2.584-5659:3598.&6512&)-&./)%-4.-.&35 @rCer/372/25_1821_CCS ATGGGGCAACGGCGGGCGCGGACGAGGAGGTTCCCGAAAGCCACGCGCAGCTGGAGCAGCGGCGACCGCAGCTGGAGGCCCGGAGCGCCTGCGGGGCCGGCAGAGGCGAGGGGGTTGCGGGTAGGAAGGGCGGGCTGCGCGCCCCGCCTGCGCCTGCGCGTCTCGGGCCGGCCATGCTCCCGACGGCTGCGGGATTCAGCATCTGGGGCCGGGTTGGGGCGGCGGGTCCAGGGCGCAGGTGGTGCGGCCGATGAGCCGGGCCGGAGGCTGAGGCCGCGCGACGGGGCTGGGACAGCGCTGGCATCTTCAGAGCAGGCCCGGGGCAGCAAGGGAGGCGCTGCGATGCCAGACGAAAATATCTTCCTGTTCGTGCCAACCTCATCGGTTATGCCCGGATTGTCTTCGCCATCATTTCTTTCTACTTCATGCCCTGCTGCCCCCTCACGGCCTCCTCCTTCTACCTGCTCAGCGGCCTGCTGGACGCTTTCGATGGACACGCTGCTCGCGCTCTTAATCAAGGAACCCGGTTTGGGCCATGCTGGACATGCTGACGGACCGCTGCTCCACCATGTGCCTGTTGGTCAACCTGGCCCTGCTGTACCCTCGAGCCACGCTGTTCTTCCAACTCAGCATGAGTTTGGATGTGGCCAGTCACTGGCTGCACCTCCACAGTTCTGTGGTCCGAGGCAGTGAGAGTCACAAGATGATCGACTTGTCCGGGAATCCAGTGCTTCGGATCTATTACACTCGAGGCCTGCTCTGTTCACCTTGTGTGCTGGGAATGAGCTCTTCTACTGCCTCCTCTACCTGTTCCATTTCTCTGAGGGACCTTTAGTTGGCTCCGTGGGACTGTTCCGGATGGGCCTCTGGGTCACTGCCCCCATTGCCTTGCTGAAGTCGCTCATCAGTGTCATCCACCTGATCACAGCTGCCCGCAACATGGCTGCCCTAGACGCAGCAGACCGCGCCAAGAAGAAGTGACGCAGGAGCCCGGGTCCTGGCTGCCCACCTACCCTGGGAGTCTTGCTGTGCCACACAGCTCCCCACCCGCTGCTAGGAGGTCCCAGTCTCACGCCTTCCTCATGTGTTGTTCTACCTGCTGGGATGGGGGTCAGCCTCTCTTTGGTGACGTCATGTTCTCTGGATCCAAGAACCCAGGCCTCAAATCAGGGAGGTTACGCGGGAGGCCCCATGCATACAGGCGGTGCTCCTGGGTGCCAGCACCGGGCAGTGTCATGCCCTGCTGGCTCAGCCCTGGGGTCCGAGATGCTAGGGACAGTTGAGTGAGGGAGATGGTGTGAGGGCCGCGTTTCCCGAAAGGCAGGGAGTCAGACCTCCGCCCCCAGCTAGAGCAAGTCTGGGGCACCGTGCCTGGGAGGGAAGAAGCCATCCACAGCCTTCCCCGTCGCCGGCTTCTCTGTCCTGCCTACCCTGGTCCTGGCGGGACTTCACTATTTGACTTGCTTTCTTTCAGATATTCTTGGTCAGGGCCTGGGTTGAGGGAGCTTAGGGAAGGACGTCCGTCTGGGTGCTTTTCCTCCAGTTTGCTGGCTGGCTCTCCGTCTATCCACAGTGACCTCACAGAGAGGCCCTCCTGCCTCCCACGCTCATGCAGTGTCCCCCACTTGTTTGATCTCACTGACCGTCTACATGTATTTATATTCTGTATTTTCTACCCTCACTGGAATGTAAACTCCATGAAGGCACAAACTTTTCTTGTTCCCTTCTGTATCCCTAGAATAAGACCAACCTGAACCTGGCATATAGTAGCTGCTTAATAAATATTCGTCTGTCAG + ?I4KIIJAEIBHC-DJGHJCK=JJB:IIHK6D8JJA)FAEK>@FEKK>G?BDHCGIKI-IH53K>EGKBCDKHAG(KKKI6EIJBKECFFKBJ@JKG-GHFCFHIIJ$BD@K;@$G81G=4?II;K?FGDK0KKJEJIFFK>IK1H7JC@JH;<;4D,@FB@JHGG,JIKHH1GD>F8CKDH9GKDGC@0IG@DCDF?6J1FB6@FKKHJJ/G-HIG9:74GHA<@=FIC5>B;@6AB?FFIF>BDFBKHHIKBH7K0JK3G.I2*KFDH7DCH>2KDG*GHH@5ICKEJFI;IE*J.KJ?IGEJG1$FF;FE4GDI;HGHJJ;I?2B6G5JJI:GCA:J>DK>JK8JDJGADH5HIH4FIE@2HCCGJHAKBHIKJG@3E7<<=@JHHKIG-IJ<+6FEBBH=EE9JF4;EB8DEJKIGIHDBCAJD$AJIG>G;KHIGGJDBEKB::J/J>:&78E6'DB7C@DGGD559HDEDA2G9I;4I81;IB:<8EB9C=GAKK8AK;JKD@-EDKCHEID<6KKEH=CBA4FCJDB;JKCKEGFDIGFIJIBC+BBIJHGIB8IFJGKEHEHCIIGGEFCFACIHJCB@B;KE@HIJIJC;JJIGHG2KKGC-K?;C2HAHB;EH@:BCAFJGFHHF8BKAHB4J>JHCGFGJCIHHHHJJAJF=&JK6>KIFKIAEEFG,KCA9CD@1JIF&KJEAH>EGIJ@IHIIKIFHDEHEG3EFHKI?IHEICG3H8/ID>(/FDJF28JHAD)CKJKAJEG>I4D8E,FJ=KIJIFAHJGB$EB:,F@KIFKJJKKDK1I>A1HJCF=)GHGGEEHFECCAKJCFJ7HHKDJJ<5GIJECJIDKCI9:1F9$;@AGHK=HHB6F%BA@EJHIHGE:DH-IEIKFHJ8KJFIGIIJJDFGB;JI0IBFH;JI'D:B7JJ5IIF&JIF???;BBHIJ4KF+JKKKGEF9GGKHF9CJIHH/JJKJF5D>F9DKF-IIG&HB5B*9IB9F@A=<;?63.@:D9FE>?;@C0?5DD2AFCA>:22E+@':2:2GC>AEC:CB>A=4EG><1==E>?E.DFF@?7D@D5B6%8?FEFC@<@+:=6@@=#0D(C>:D>=FFBFF>>CEBC>DC@:DF2;BFEF@B4B?B?>'A<E>;5:D=C=D?BB3CCC3ADEFEA5@A0EE&C?>??@C70=DF@<8=?*DDA=;A9DB.EF=@@CE;@B;AD:GE25=@/DB2?3(8:'&/;+?=>9C=$8<7=:8/7E7E<=A@GEC?,B?@>BG2GDF@.?FA:AACF;C@8B0CEAEF=D@1>AFEBC46;?7=9C?D?CIA@ @rCer/375/2678_62_CCS ATGGGGGGCGGAGTTGTGGGAGTGGAGGAGGAAGAGGCGGTGGGGAGTACGGGGGCTGGTCCCAGAAGATGGCGGAGGCGGGGGATTTCTGGTAGGTCCTACTTTAGGACAAGATGTGGTGGTACTGTTGAAGCGTCAGTCTTTGATTCACAGACACTTGAGCTTTTCAGCTGGGAAGCCTTTCCTTTTTTTTTTTTTTTTTTTTAACGGCTTACTGAACCTATGAAACCATGGCGGAAGGAGAGACAGAGTCACCTGGGCCCAAAAAATGTGGCCCATATATCTCATCTGTCACTAGCCAGAGTGTGAACTTGATGATTCGAGGAGTAGTGCTATTTTTTATTGGAGTATTTCTTGCATTGGTGTTAAACTTACTTCAGATTCAGAGAAATGTGACGCTCTTTCCACCTGATGTGATTGCAAGCATCTTTTCTTCTGCATGGTGGGTACCCCCATGCTGTGGCACGGCTTCAGCTGTGATTGGGTTATTATACCCCTGCATTGACAGACATCTAGGAGAACCACATAAATTTAAAAGAGAGTGGTCCAGTGTAATGCGGTGTGTAGCAGTCTTTGTTGGTATAAATCATGCCAGTGCTAAAGTGGATTTTGATAACAACATACAGTTGTCTCTCACACTGGCTGCACTATCCATTGGACTGTGGTGGACTTTTGATAGATCTAGAAGTGGTTTTGGCCTTGGAGTAGGAATCGCCTTCTTGGCAACCCTGGTCACTCAATTACTAGTATATAATGGTGTTTATCAATATACATCTCCAGATTTCCTCTATGTTCGTTCTTGGTTACCATGTATATTTTTTGCTGGAGGCATAACAATGGGAAACATTGGTCGACAACTGGCAATGTATGAATGTAAAGTTATCGCAGAAAAATCTCATCAGGAATGAAGAAGGCAAAACATATCTTTTGTACAAAAAAACAAGATGAAAAGGATGTGAAGTGGTAGATATACCAACAAAACTTCAGACTGTAAAATTGCCAGGATGCAGTTTTTCCCTTGATTGGCATGTGTGTATATATGGATAAATATACACATATACACACACATATTACTGCAATCTGTGATTGCTTCATCTGTAAATCAGTTGCAAACCTTTATGTATTTGACTTAAATAACTGTAAGATATATATGTACTACATTAAAAAGTGTTGATTAATAGATGAAATTTTTAAATTAATTTTTTAAAACATGCCACACATTGTTTCACAATGTTAACGTGCCAAAATATTGTTCCTGTCATGCAGAGTCTAAGAATGCTTTGAACAATTTGTAAACTTAGTGAAATAAAATAAGAAAGCCAAAAACAAACAAACAAAAAGCATATGGGGAGCTGGTATTTTCTCTTTAGCTTACTGTTGTGCCTTTTATTTTTCTAATCACAGCAGTATGAGTTATGAGTGCCCTAATTTGTGGTTAGTTTCTAATTTAATGCTGTTTCATAGAGTTTGGAATGTTTTGATACAGGGTGAGAATGGACTTCTGGTTTCAAAACCTGCATTACTGGAGACAGCCCAAAGAGTAATTTTCTGTTTTGACAGATCTTACTGGAAGTAATATGCTAAGCAAAAGAGGTTATCAGCATTAAATTGTTTTGGTTCTAAATTTGGAACACTATATATAATTAAAAGTAAGGACTACTAGAGGATTTAATTAGAATAAATACATGTTTTGGAAATACAGTGACCTCTTGCAGTGCCACAAAAGTGCAGAGTGGTATTAGCTGTCATCTGCAATACAGAATCTCATTGCTTTTGCACATGAAGCATATAGGAAACTCCAAACAGATCAAAATGAGGTTTCCAGTTCTGTTGGATTCTGTCATCTATTGGGTTCTATGAAGCAAACCACTGTAGCTTTAGCTGGGTTCGGTCATATGACTCACTGTTAGTGGAATGCCTAGTTTTTCATCTTATATGCAGTCTGGGGAGTAGATGGGTACATAATTTCTTATGTATTCGTGTGTCCATTAGTGAATAGTTCAAGTCTGTTTAAGAATGTTTTGAGATGGCATTCTCTGCATGTTAAAGATCTTAATGGCAACCAGCACCTCTTAAATATGGTTTAAACATATTCTTAGCTAAATTTTTTCCATTAGTTTTTGAAATTGATGGCAGTTGTCTGATCCACAAGGGCAAGATCTTCTGAGTACTCTGGAGTGTGTGTATGTGTGCATGCATGTGTGTGTTGGAGTGAGTGAGTGACAGAATGTGTCTGTGCATGTGCCCATGCTTTCCTAGAATGTCAAGTAGATATTTTTACATTTTGAGTTTTAAAACAATTGCTATCAGACTGAGATCTTGTATGCCAAACTTTAATCTGCTTTTATGTTTTCAGGCTGAAGGTGTGAAAATCCTAAGAGGATTTCATATTGAATATGTGTACACAATCTTAACTATTGTGGTGGAAAACATACTACTATAATTTATTATTATATCTTCCAGATAATGTTATTCATTTAGAACAAATAAGGTATATTTTTTAGAATCAACTTTGTAAGCACTATAAAATCTTTAATAAGTTATAAGATCTATGATGTGTTTACCTTAAAAATTGCTGTTGAAAGCAACATGTATTAAATACGTAATTATCATCTG + ;2<>DDD/CCAAA>4D9A@7;B5;38E9=<&>;EC9<@DCEBEGEGC5@AA=BBF1?:F:>@CC>@EDDGA=<>=A%CEA=DEEDC4;CA7AB8CA?6<=76@DB=C6EA>BFE=E@BB=?D,C@DDAEDC>A?;AB;FEFCFFE6C8?F>BG:EDBEDGE7@>AAA>BBBCB@@CCCCD?=A$;GGEE@:@CCDGDF@8>>B815DA:DAE@:E@>8@FBE@DCDD8B>?8E;EB@AA<.715BB@DAG7DE?F?DC:FB85@BA;;=;C*:C6G@FGDABG==D?@E=?.C>?BA5AC;8A=>CB;ACE;GB@BBAC>=4;E??>EA>DADD@EAB?1E>4EFE?AD@FFG@FFB4EGGF?DGBGDEE<='?4AEGD6EGEACD8CA;3>A2DGBFCFEBFCBFD=FDEE0@B==DE,BEF??/<8C=CA=BB@@?B;8AADCF<>=FGFDFD?EED6EEAEEC=6CF?EBECAA6:=:A79@DBFD>CD6EE>C7@;<7@/;=4:>A8CACFB>@D2@=F?DDBA)<@?A:4B49+63B=AB@>EC?ECEEDADFF3D:>CA>CBBD@'8@D@?<9CA>FF@FBGCEAB7E>=CE>C-BEA=C@D<>DBGFGCED;F?7D7<@>@F;E?C=78B2G;BDDA>@>@<FB6,7BBDF8D=FD==A>2CF67?C.EG4FFD:A9EGCEED:BBD:@B9FB>BA?ECGECBD=C>D@CC?=@DF@CB6?;6?>AC>BAA+B7=D<@FE?/?0:FEB:DAC'DBGGA?FAECBC?DGEDG=GE6E?A3D?F?A?CE?=ECC3BGB@BAF?=@ADFEE:DC?>EBB?ACEGEFD@?E;ED><8G:D9A?FEDDGCBDB>B1CDGE0D6DD/BBBAA?B:D:CA8CF1DB>@;A/@<>9;14>2;5B96EAC?A=95EE9+16$@ADDG?7C>C?D?CCD;C4ED@BCE8ECA?>CC;5AE%=@G?DF>D@CBC@>AFB;FC=@:9FBDC2AA>CD/BD?B<;DD47BBC4CA8D?>7;B8@AEG=DD<=EF?AA2C@EE5B>E6CEDA@>>A@)@CDCC8>FE-AEDEGCFDE@E?CA@@>7EDCF?9FC>F7=>=80AEC%0CAED/E>?9EA:DBGE@A?@7AAFFEGC=0C>9AE:>E8C@>97GDFBFFEE=FAE=GG@C.>@BB?D@7E??EFBCDA3EDE9F>FGE,CBFGDEA@76416@19C89?E.@?B>??+@@CC&5>3=FDDA=?=C8A??DEFFGAECABC>@FC8;E8+EI>BF?H58HG@IGFIFIFJDHHHHH2GBFD?AEE7?C?C%5A>D:=<-?5BBGBECFJFJGEDEB=I@EEHIIIAIHGC8BBIH;E;EHHGF8GHGEFF7A7FEAB=68@;<>CCDBAFED=CC?F@A;A>CA6ABGFGC>FDDFB?>C@4BEGED<6DHIC?F@>IDAHEBABF>HGEDA?=>7AA;DA:@(A7=E,@EHHG7IFHHEFADDF=E<=CB?5<@D=DDCA9E>=DBGH:H:DIHDJE?IE?IJAHBGCGEF?@A5D?D=9/<>8DHADH9?@AA>D+EEB=7ADBA@@,AFA;:6EB>ECECDE@?7B@GD@ECD?GBGH5FG8C6DDC?@;5@A;@ICHHJFCGBF?>A9AB?>7EAHIE;GAE?EGHHIHIGHCFDBDCGDFBD9BCEH>HCHIIJGHI@FJHEHEG>EFFGII*FIEGHG7HFDGGC%?GG.GHBG4C?=FFC:=FDFII@H7GE4GAE=EA?G@9EGG7I@;AIIDFJHA>ADGIHIA4H?DG3C@=>85BBHBHDEHBCJEIHGIDD?BCFE@8CH@IEJE=F=DHIIHHJJJJH:??D?FHIDBHD2DEHI4DGIH:D7EE6AGA=6?CC=>BE96@BB.??EDBFEBFF=BDE?FCBFBE@@7=EFC @rCer/376/2035_54_CCS ATGGGGCCCCCCTCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + 6CDFB;AEAEE17DC.D>5>8FB>85E?C<@>:@@@B2D@=DA==GD:'8BCCECDB>/CCDFCB@EFF9<=:E9C?BD8?FFFF>CD?D@=B70C>9C:DDEB@EC>29FFE0FB6CG9AF2B@EG<9FA9F95@GABFD=EEFGF;DFE=9FG@CFF?C>A5A8A@D7DEEAEF=7ECF7E=@?;EGFC83@0>EE@?@?2B=<=BD@7DE@>?>9@.7;AGBE;@G@GCFGCC7=6GE=BFGGGC>CBEE6>C1BC4@E*A3;???7CAEE;CFD3ACEBBC7BADGBFEEE?DBBB;8?$552CEAD6@EDFF:6?CABE?CCDA3<;C6D4=?>4CA@E??E:BFF?@?=7B@8@EFCDFEC?:7BICII?F>FCE?C>H:EEEHGHI=HGGH?>CA5FH>CC$9?FE6A+C6@HIF;A*AI:F@>AC*GEHB@FHG@CJJ>EDFHCFGHCD@EBIJGIAHDFCF<9CCF>A=?@A@DE;IFHF=)I:>;E>CIF@EEBE@DE1BACA<4?@6DE7DIIIH:E<-<<2C8-A=@D=C6?958A;DIFGH>G4I@=FIIHECG?EDEB>EID?HC3KHJIDEEACK:DJKIIKK;G9E@=CHDHHAGFGA>FI7F,E6E6HDFDJEICJHD5DH8CB@GAGCD27=8C;E?BHGJIK@KH?EI7FGGGCJDEAFIHJ?HDFFKHI@JJIJJJ>GIDIK>IKIBG>JIFKCHBKIKEJGIDH?8FA2@GEJF=@HI=H9=CDGI?IGEGC@JIJGHHFIFFFE:(ECAH9GGEDD?JHHJAIBH=6JJEG=>;>CEDCGD6BIE?BGGHHIIHDEE?G>A>H;JIGEHHI4@H@@D=%=@@$7CB9E6GIGHHEG@CEB>@;B=EHF4@E+EIGIJ>F/EGDHIB:3=BF?BJFBEGD<6FCE2GHH?GCDFI0IJII@HEF@5GIJ7IIJEHJFIHGDBE8=8ABGG6CDJDGGGF?;:>F7E?FA9DFHCB=GDF=E@?HHF=;EDDD&DIBEIEIIGIEHHEDEHFGCA?AB83>;BDB8GJEDFGHIGF=F>BHA5G3GABCDDF?IGIIAGEJ?HIAIGICEBHG8GEIIIDHG@G7JF@GJCEJHGEHEHHIGFFHI2IHIIGIAI=-5AHIHAH5DDEHHADGDF?IFFIGHI;HIHFEFJE@JFIGEFIC:HDIEGG>AH*CADFIJD?56BFDE?IDAJ>CIJ:E>IFI@GDF:>?1IH@DCIHCCBAFF3HHCF>6F@9BDG@B64>2I=CEDBFFH7HE9HFGAD;AFB5G9HHCCIHBE9@@DA6A>&@>IIIHJB3B7BGG?F@AE:B;HIGHGC?E@D9=HCEEEDGI @rCer/377/25_1931_CCS ATGGGGGCTGCCAATACAGCTGTCATGGCGTCCGAGGCGCTGGCTGCGGAGAACTGGCCGCGGTCTCCATAGAGCTGGGGGCGGGCGGCCCGGTATGGAGAGCAGCCCCGAGAGCCTGCAGCCGCTAGAACACGGGGTGGCGGCCGGGCCAGCGTCAGGGACAGGTTCTTCGCAGGAAGGGCTACAAGAGACCAGGCTTGCCGCTGGTGATGGTCCTGGGGTATGGGCGGCGGAGAGCAGCGCGGGAATGGGCTGGGGGCGGCGGCCGCCAGCAGGAGCCTCCCGGACTCGGCTTCTCCCGCGGGCTCTCCTGAGGTTCCCGGACCTTGCAGCTCCTCCCCGGGTTTGGAGTTGAAGGATAGTGGTGTGGAGAGTCCTGCTGCCGCGAGGCGCCTCTGAGAGGGCAGTACAAGGTGACCGCCTCCCGGAGACAGCCGTGGCCGGAGTGGGTCATGAGTTGGGTCCCGCCGGAGACGCGGGAGACCGCCCGGATCTCGCCGGCACCTGCCAAGCAGAGCTGACGGCCGCCGGCTCCGAAGAGCCCAGCAGCGCCGGCGGCCTCAGCAGCAGTTGCAGCGACCCGACCCCTCCTGGGGAATCGCCGAGCCTGGACTCTCTGGAGTCGTTCTCTAACCTGCATTCTTTTCCCAGTAGCTGCGAGTTCAATAGTGAGGAGGGAGCGGAGAACAGGGTCCCTGAGGAGGAGGAGGGCGCGGCGGTGTTGCCCGGGGCTGTTCCTCTGTGCAAGGGGGAGGAGGAGGAGGAGGAGACCGCTCAGGTGCTGGCGGCCTCCAAGGAACGCTTCCCGGGACAGTCTGTATATCACATCAAGTGGATCCAGTGGAAGGAAGAGAACACACCCATCATCACCCAGAATGAGAACGGACCCTGCCCCTTGCTGGCCATCCTCAATGTTTTGCTCCTGGCCTGGAAGGTGAAACTTCCACCGATGATGGAAATCATAACTGCTGAGCAGCTGATGGAATATTTAGGAGATTACATGCTTGATTGCAAAGCCAAAAGAAATTTCAGAAATTCAACGTTTAAATTATGAACAGAATATGAGTGATGCCATGGCAATTCTGCACAAACTACAGACAGGCCTGGATGTAAATGTAAGATTCACTGGTGTTCGAGTGTTTGAATATACACCAGAATGCATAGTATTTGATCTTCCTTGATATTCCTTTGTACCATGGGTGGTTAGTAGACCCTCAGATTGATGACATCGTAAAAGCTGTTGGTAACTGCAGCTACAACCAACTAGTGGAGAAGATCATCTCTTGTAAACAGTCAGACAATAGTGAGCTGGTTAGTGAAGGCTTTGTAGCTGAGCAGTTTCTAAATAACACAGCCACTCCAACTGACATACCATGGATTATGTGAACTAACTTCAACGGTTCAGGAAGGAGAACTTTGTGTGTTCTTTCGGAATAATCATTTTAGCACCATGACCAAATACAAGGGTCAAACTGTATTTGTTGGTAACGGACCAGGGGTTTCTTACTGAAGAAAAAGTTGTTTGGGAAAGCCTACACAACGTAGATGGTGATGGAAATTTCTGTGACTCAGAATTTCGTCTTCGGCCTCCTTCAGATCCTGAAACTGTATACAAAAGGACAACAAGATCAGATAGATCAGGATTATCTTATGGCATTATCTCTACAACAAGAACAGCAGAGCCAAGAGATCAATTGGGAACAAATCCCAGAAGGAATCATTGATTTGGAACTAGCAAAGAAACTCCAAGAGGAAGAGGACAGACGGGCTTCTCATACTATCAGGAACAGGAACAAGCAGCAGCTGCTGCTGCTGCTGCTTCTACACAGGCTCAGGGCCAGCCAGCACAAGCCTCTCCATCAAGTGGAAGACAATCTGGGAATAGTGAACGTAAACGGAAGAACCG 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20,5546524(2.3/05.0425524*324./&/36331.*.+.*050-/00.5--365533-/,./,5*3226462$0--%&$-0,*1,4516452+//-/-1,/.1)2-,2/5461/*/42456403-3442-0))1-2,+.&'*,/225*4135+*24221++*0-'--2.155433230/1',5+232/43-0/$21,241105$2-*22/020,321+--/664.5.14.465140*%%)*/-54266-1%211/3255+2**-26055/3654563.66/655.3/65,4,*).0*0'132./111//%-03504416304*.$215321351656064+54*2'2261061/2636314244554314*361261*/50$0-.4*0)-4/34511/04(230',.$1665504./3-$12.1+1/00/36641206-4000445255*,0/41(.1)&1../116452)21&-+(%%&-4.4411+13141+0-450,1,2264542322030.(2/6.51.015405561655303520142-*16215+-)-)+.31/2240.452303/*(0653.424-.2.+34524.25550.*02356*-04+,(06.21'/,1*.0/-5*.0),+3/4(1.1.5/05./-0151344.0(+0401344255/61503.'+'%113//3.(40%+('(),0+0/4,41231))-,1304664560665420-0463+56144,2%222*.(2223305026000101.50500**,.)/4045*3*311236+54355326(1.*+00*0*410'/12.32,/434/545)//'-6.1*0602/201445.53303056414*3212/45/04.435240/54*,,.4-642.325.*0.2..+2351024)4154/4/60,211634*52214121113/6124022,35+4305311+1656633/-/042140..*3-4/.+//1160'/'01-1104(-,/&.3.1461'5+4532'44066112&02)..-530-35251/302403/24/32+10+4-0522.2-/141,-/)00$+,004045264623,*,+2310531)*/2*1216+3.20420./*)'1..2-441+1/-0.02,/.15/+'**214+(010//135++12$'+1.0.0)/,5*/'1*)10+.%*''&-)./3524+0666421111'/-2022++-0,6644445)31:5+.1735050)13,,-0$.-%/)+'.-(*/)'').,+,%,-**.-,//*/110,,((+*+,*)''(+(++.,+,)+',*(**+,**001000*/(-)&%&++.+-,)+*&)(*'+$&(,*)**&'%$$*%*&')',(#&+*.2(&,+0),0&/-,((1--0--0,(-(&+,-2*).,0/)/-,1-,-0*++.0..))00,'&(-,,,/,+,-,00*+*,,'--,*%,//,++/'/*)&%&-1.---2-)-0)01.'//.-,/10...0(0/11,,0/).0.01'/-,)-0.+.+#+-.,0++/'-)+*)+1,0,-..--,-)(-+&/0)-).-*,(+(*1.0)-,*+00111,'))(-+.2+(-'('%+##$#%+)&)+*((***&&&*&)%(*',,-,((((())-*+.+*),,-&-*)*.,-+)/-00,+*.//*/*1121)0,),+212.,2,0-100/',,/0)010*1011,-/*%0/*1/2/1001-22.'.///-2021-,.,1-102/-%*00*+0-+00+)'/1.,(,,000/2,0/2111,1,*,)-,01)/0-,,11110/011,00*-,)'/.+0/(*%,+*10-)').-/-.2.,.0%*'..0112/11112-/0'100/&.,)-/)/./-00-1-020.2,+$*+,1. @rCer/380/1936_60_CCS ATGGGGTCGCCGCCGCCCGAGCGCAGCCGAGCGCACGCCGAGCCCGTCCGCCGCCGCCATGGCCACCACGGTGACCTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATTGGCAAGGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATTCTGGTCACTGGTGGGGAGCTCTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTCGGCCTGGCTATCGAGGTGCAGGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGACATCTGGGCATGTGGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCCGAATGGACACTGTCACTCCTGAAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGAATTTCTCAGTGGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGCCCCAGACGAATAGCACCAAAAACAGTGCAGCCGCCACCAGCCCCAAAGGGACGCTTCCTCCTGCCGCCCTGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCCGCACCAGCCAGTCTGAGGAGACCCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGAGCTGCGCCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCCGACTGCCCTCGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCCTGGTGCCTGTGTCTGCAGAAAAACAAGACCAGATGTGATTTGTTTAAAAACAAAACAAAACAAAAAACAAGATGACGACGACAAC + 3/989+>?>=99;<:65,;>=:;625?:;9;3:33=7:7;:7:3575=<=<::8.-+.8>?8;99645988/9818:37<5276=499=:7464/69?88<=:89<:=:;2=839297;5266749/=7>88;3;493426.3/;:14=>=9<<564118:8852<2>>?964/=468/6<<8=479<802-<730$*82:2;85:5=<455959:<=9797>;1198=:;7>9=47758;870679/:7=*71*<7:513<48>955846<4+&05767=856=5:475/,59>9:%5234=:68;:1=544163/8*48841;<>=85>47152//=3460.4-166//6/0:=1>4<<9;=<>9:<907=??;2<;473+1:2)8=61708>88?9;2465073859=9<9=8--98874;:6578,9><28649>>6>=4:>>93=<957945<282390889;>;8?:;4778<<712::9<89<-;3/>9==4;?;=::763>:-29/=87=9:;/94895;>:16<9?:5>78*5;6::1=7=(>9=$;<0<<999;*:;?:?B=:=B>?2=;7;399<01576A9<=@,9:;<:77998=6:81;@<8:%264(=;;>9>,;/99=1:>7;984>8;=8>=6>C5C><5=9=:=->3;9@<;=@>@;?9=?8;2-=;<$=<<6='9948:=:=:>=?79;=.=7:9;79(168A;?B?0B8<;A@@B@?:>8889@8<@/8A?3;7=2@A@@0(3;?:7/,.20C>-?@9;>A>>A?C>9@75'7;663=A?=?:;A59:?B=BAB96668?26;<8@A6:B:,=98?>4=:526=>5==>5>5:;;7==39<8998968/>299496;5<1<669@<;3;9.9/=A<<>?.=<39=>;?C>;?8=966(68?43=@>B=>?B@>;A<7?5:,:<1><6>>;<;8'>9>9?AA:7?8?A76>>B5@84=;A?@88936)8;;4'=:9BB7;0A>?C57==>ACA>3C==@A)?;89B?@=A:8@;<,<@:9<9579@7@;@?;?6?=/?>B8=B@:C:<>?A@9@@;'85169<;A9@8998<;;41>/<@A6@>:B==:6780:BB:;:3?<:>5:1>?<2:6>?@>;AA6;9<8=:38:9676-8365=9;<0=?6;252.<:730:<:69$50,539<;6.-0,54327>5379/:899:1+71739;/8987=<4:5:39;:&9/9:1:(<;><:6;=;:64?.==::2==8:896)5>>:;>><89:64/5766&3>:;5;/?5;26/:<4<=<;693<;9>5=:>:;4=6868<;.:;?;8>::99573;9:46/9?<:8:.=9<84978;=.>;4<::=7;33+4;0<56=>6;89,:9=7:7:=;898;;::;>?>=;9953;9/+319360:49;)203,858:135957241<<:;;706)45479,6:;>==;=9<5550863;4=797:>:3.%473<>9.288/;>5>=9.<59:;39489;:4822<*7=<7823>71<8;7;7)19::/987<9711:894725277::>;1::3.94K8KKKKIKK;B1KKKIIEKJK:IKJGGFKKKK'KK-JJKKJJIKKKJHKHKKJKG/H2B4JHJKGKKKKKKKKJKKJKHKJ3KKKKKIJFJKJIKAKKKGFDKKKKDC4KIKIKEKKKKA2C-IKKKKKH@JKKJHKI2KJKIJJKGEHK/I>KKKKJKIKK7KKKKKKIKHKKKKKKKKKK>KKKKKKKKKKKK:KKKKGKKKKKKKIKKKIKKKKKKKKKKKKKKKKFEJKKKKFKKKIKKKKKK;KKKKKKKKJKK@KJKKEKKKKKKBKKKKGKKKKKKKGJHJIKKKKKKK6KKKKKKGKJKHK0KKFIIKJKKKJKJKKKKKKKKKKBKKKKKKJKKHKKJKKKKKHAJJKKJKKKKKKKEKKKKIKKKHKFKKJKJKKDHJKJKCKEKGJID>K?G;<@KJD;JKKJJDIAF;KJKKGDKK9KKKKIJKKKKKK/KKKEJKKKKKIH9KCKKKKGKIKKKGKKKKKKJKJKJHEIFF+KK0KKIJKEKKK:JKIKKKKGJJKHKKKKKJKKH.KIJK@BG-IK5J7KK@KAKI<2KKKKJH>HA.IJKFK:@KJKJIKKKKKKKKKKKKKKJKDKKKK;KKKJKJKKKFKKKKDKKKKJKK4K5KKJKKKKKKKKKKK?KJKJKKK?KKFKGKHJKKJKKJHJJJIKKB.KKKKGJ;KKKKKBBGK'JKK2;KJKFKKKGKEKKKKIKK=9@KJIE;KK*KIKJKKKKKAKJKJKKKKKKCKJKKKKKKGKKKKJKKKAKKKKKKKK@KKKCDK.KKIKKKKKIIKKIKK=K;KKKKK>KJKKKKKKK0JJDKKKAKAKKI=HKKG=JJK;KKKKKKJ@EJKKKKKJJK7J?IKGDKK6KKKJKKKKKKKKFKJKH>DGKKJHJIIGJKKKKKJI7KIEKJIKKJJ>E@KKAHKKJIKIKKKIJIKKKAKKFJKKIK;KKKKKKKCCKKKAKKAEKKJJCJKKKKC6>GJKKK9>=I7@IKCF<8KKGGKKE.KKJHKJKJ7KKBKKKKK@EKKJKBJJ9FIIKDKKKIG@KKKKKKKEFF7BJJKHJKEKIFK*IIJHCDKGJHKKKDKKKKKKKKKKKKKKKICE2KIJKJJKKKKKKJKKJKKKKKK1KKKKEJHJEKKJFKKJKKJKKJKIKJKKKJKKKKIKKJKJKKKJKKEKKKKK+KKKIKKKKKJJKGKKKKKKKIJKDJK@HHJCKKKKKKKKKKDKKKIJKJKKKKJKKKKFKKKKKKKK:KKHKJKKKIIKKKKKJKJKKKKKJKKKKKKKKKKKKKKK>KKKKKKJJKKHKKKKKIKKKKKKKKKKKKKKKKKKJKKKJKKKKKKKKKJKKKJIKKKKKFKKKJKKKHKKKKIKKKKKKKKKKKKKKKGKKKKFKKKKIKKKKKGKKKKJKKKKJJJIBKKKKKKKK?KKKKKKKKKKKKIKKKJKJKKK3KKKKKKKKKKCKFKKKJIKHKJKKJHKHKKKKJKHKKKKFKK>IK2KKKKKKFKKJKKKEKAJKKGJKKKK)D43KKKK0KKEJK;=JKKHJKKIJIKKKKKJ:EIIKKGJJIK7KKKFKKKKIEKJDKKCIKKKKKKKKHJKKKKJKKKCHFJDAKAKKKDKKKJKKKKKK>GHFKHHKKKKGKKKKKIJKI;AJKKCKJDKD2EJD2@KKJKKKKJKKKKKKHHJKGKKK@IKKJKKJ@KBBDKJKAEKKKKKGG3KIKKKKKKHHKAKK5KKFKIBJJHKK=KKIJJK>KKKKKKKDKJJJIKKIJJKKKKKKKJKKKEKFKK(KKKJFKHDKCKK5JKEJKKKKKKK@7K;KFJKKDKKJ@KHKKKKKFKJKKKKKKKKCJE=EKKKKKKK0KGKGKJKKKHDIKKKHKKKKKK*KKJK5KKKKKKKKKGKKKKFKKKFCKKKKKKKKKKDKKKKKKKIKKIKKKHKKKKKKKHKKJKKKKKKIKKK?KHJKHKKJKKKKKKCKJKKKKKKKKKKK1JKIIKKKKJKKKKJHKKKJKJJ=KKKKKKKKFKJKKKKKKKIKKKJKKKHKKKKKCKHGJKIHKDKKK@KKKEKKKCEKKKKKKKKIKKKKJKKJKKKKKJ>KJIKK0KGKKKAKKKKKKKKKJKK?KKKKKKKIDIKK>KKCKKKKJIKKKEKKKKKKKKKJKKIKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKFKJKKBKKKKKEKKEKKKKJGKKKKKKKKDKKKKKFKKKKKKKKKKJKKKKKKKKKEKJGDKKKKKKJKKKKKKKKJKKKKKKKKJKKKIKKKKKKKKKJKJKJKKKKKKKKKJJKKGKKHKKJKKKKKKKKKK:KKKKEKKKKKKKKKKK>JKKIKKKKKKKKKKKJKKKKKKKKJKKKKJIKK5KKJKKKKKKKKKKKKAKJHKKIJKKHKGKKKK6JCKIJKIKFKKKKKJKKKKDIKKKK @rCer/390/3334_51_CCS ATGGGGAGGAGGGGCGCGGGGAGAGCTGAGCCTGCTGGGAGGCGGCGGCGCAGTGGAGAGAGCGGGAGAGCGAGGAAGGCAGAAGGAGGCAGCCGAAGGCCGAGCTGGGTGGCTGGACCGGGTGCTGGCTGTGCCGCGCTGCTTTCGGCTCCCACGCCTCTCCCATGCGCTGAGGGCGCCCGGCTGGGCCGGGCCGGCGGCGGGAGGGGGCTCCTCTCATGGTCCAGAAGCCGGCATGTCCGGGCCCTTACCACCCTCCAGGAGATCCCATGGAGTCTTCGACCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCGGATGGAGCACGTCCTCAGATACCACATCAACAGCTTTGTCGCCAGGGCTCAGCGGAGTCCTACACAGCCGTCCATCGACTCTGATGTATCTCTGGAGGAGACGGGAAGCCTTAAGGAAAGAAGCAGAGCGCCAGGCATTAGCACAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCCGTGCGGACAAATGTGGCTACAATCCGTCTCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATTACCTTTGAGCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGCTGTGAGGTTGGCTTCATTCCCGCCCGTCAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGCTCAGCTCCAGCAAATCAGGCGATAACTCAGTTCCAGTCTGGAGATGTGGTGACTGGCACCCGCGCCCCACACCCCTGCCAGTGCCAAACAGAAGCAGAAGTCGACAGAGCATGTGCCCCCCTATGACGTGGTGCCTTCCATGAGGCCATCATCCTGGTGGGACCGTCGCTCAAGGGCTACGAGGTTACAGACATGATGCAGAAAGCTTTATTTGACTTCTTGAAGCATCGGTTGATGGCAGGATCTCCATCACTCGTGTGACGGCAGACATTTCTCTGGCTAAGCGCTCAGTTCTCAACAACCCCAGCAAACACATCATCATTGAGCGCTCCAACACACGCTCCAGCTTGGCTGAGGTGCAGAGTGAAATCGAGCGAATCTTCGAGCTGGCCCGGACCCTTCAGTTGGTTGCTGGATGCTGACACCATCAATCACCCAGCCCAGCTGTCCAAGACCTCGCTGGCCCCATCATTGTTTACATCAAGATCACCTCTCCCAAGGTACTTCAGAGCTCATCAAGTCCGAGGAAAGTCTCAGTCCAAACACCTCAACGTCCAAATAGCGCCTCGGAAAAGCTGGCACAGTGCCCACCTGAAATGTTTGACATCATCCTGGACGAGAACCAATTGGAGATGCTGCGAGCACCTGGCAGAGTACTTGAAGCCTATTGGAAGGCCACACATCCGCCCAGCAGCACGCCACCCAATCCGCTGCTGAACCGCACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCTGTCTCCAACCTCCAGGGACCCTACCTTGCTTCTGGGACCAGCCGCTGAACGGGCCACCGGGAGCACGCCAGCGTGCACGAGTACCCAGGGGAGCTGGGCCAGCCCCAGGCCTTTACCCAGCAGCCACCCACCAGGCCGGGCAGGCACGCTACGGCACTGTCCGCCAAGACACTTTTGATGCCGACACCCCGCAGCCGAAACTCTGCCTACACGGAGCTGGAGACTCATGTGTGACATGGAGACTGACCCTCAGAGGGCCAGGGCTTGGAGACCTGCAGGGGGTGGCACCCCCCAGCCCGACAGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGACTGACCGACACCGGAACCGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGGTCCAGTTTTGGGGCGCAACAAGAACGAGCTGGAGGGCTGGGACGAGGCGTCTACATCCGCTGAGAGGCAGGGGCCACCGGCGGAGGAAGGGCTCTGAGCCCAGGGAGGGAGGGAGGGAGCGAGGGCTCACACCCAACATGTATTCGCCTCCAGGGGCGCTGTCTCCCGCTTTCAGATGCCTTTGCTCAAAGCTTGGGTTTATCGGCGTTATCATCCCAGCTCCGGGAGGCCCTTAAGCCCCAGCTGTCGGTTTTTACCTGCCTGTTGCAGATGGATGGGGATACCCACTTTTCTGAAGTGTCCCTTTCTCCATCTTAAGGGCTCTCCTCCCTCGCCCTCCTAGAGAAAAGGTGCACTTCCTTCACTCTTTCTACTCGGGGCCCTAAGTGACGGTCCTAAGTGGGAGGCTCTCCTTCTCCCAAGCTGCAGTACTGGGGAAGGGCTGGCACTTTTCCTGGAAAGGGAGCCACAGATTCTTTCCCATGGGGCTCTTCCCAGACCCAGATCCGGGTCCCTCACCCTGCCTGCCCTTCCTCCAGCTTCCTGGCAGCATCGTCTGTCGGTGAAAGCTACAGCATGGACACCCATGGGGAGCTTGTCTCTGGGAGGGTTCTGGGTGGAAGCCGGCAGGCATACAAAACCCTCTACCCTCCGTGGCCATGCAACGTCCAGGCCAGAACCCTGAAGAATGAGCAGCTGAGGCGCTGCTCCCCTCCCCACCTCCATACCTCAGCCTTGCCTACCCTAGGAATGAGCTTGGCCTCAACATCCTTGCCTGCTGCATTAGAAGAGGGGCCCTCTTCTGCATCTGAGCCCCCATCCTGTGCCACCTGGTGTGGAGCCCATGGAACACTCTGGTCCGCCTCATTTTAAACCAAAAACTGCTCCTTCACCCTCACCTGAGGCCCCAGGGAGAGGACCCATGGGTTGGTGCCAGGGGTTGCCTTGGGACCTCGGATCTCCTCTGGGGGCTTGGCTGCTGCTGTTGCTGCTCTGTACTTGCCTCTCGTGATTCTGTTTGTTACCCATGTTCACTTCCCCAGGAGACCCCTCTCCCCTGGGGCATCCTCTGCTTGGAATCCCTGTAGCCCAGCAGCCCTGCCCCTCCCAGCATCCCAGCTGGGCCAGAGAGAGCCAACTGTGCCAACAAGGACTGGGCCTGCCGGCTGCCCGCCTCAGGGATGGCACCTCATGCCTGTCTCGCACCTCCTGTGCCAATGTCCTACACTCCACCTGGGGTGGGGTGCAGCTTCCACTTACTGATTAGAAGACACCACTGCCCACCCTTTCCCCCTCCCTGTCTGGTGTCCTGTGCCCCATCTGTCTGTCTATATTTGTCTGTACTCCCCTAGGAGAAGTATTTTGCCATATATAAAACCACTGTCCTGTC + :6584',9'-333$68556/(5.#$.29.36,4:6488-2-*84*44+,$1887;743/56(.52'').,02:;0-+8084&887)26,68:8-6925-;461&1/::.:96959.50#::3495,7,-57.+6,566-04578(9;96489/&+(207659913734464/227(7464+/*2024+3+77%:03-66,611(5;9%/*'*2)+,-'59567:/955&#((3&+26425435+,7$9+/4$+67299267+41'155'97:97-405(3978752,,.'97.5;855/)-383:::,-*3%6:673.979?<78<(<9(/8;83:7-24;06;6>/<:9:;=9;+7862%+080985=095#97669=)79:7>><5:9+<.==>6%94>1<,?:<;5#9<>;;51899,5>9>2=.830-26&);)8*89*85?;;0<<(8=0>86727:;>27<16;;78>9;;=>;5>>;<7,=;?88'*7958,<>1:>:>/6;9;138(1<8<<8:4??77728+33<9<-4:082.($'+40'5-79556*;/68:;;:86'-18=261*<21?7:;&=:8:),5'::19092<>+58;>:=0>534::('()>-=;87.1)7535=9=766.'956/587>988>99;'43:;/7=9?8:38<&3'3*72"/:<%;<8=$;5C4;:?@B6B8B?:/?B1<<<.C6=4@A;9(;AA?B@A<8=<99'3-@=B;BB::1=@?AB>;9&>B@:?>7=:98@%<=B>@;9%?;@B79&@;>9603;894$()#>;8%5=A8+7>>A5CC8:5>@6?;749@><145<>7@3=9B9?5C@2>B=7-9+/9?9@8-7>19==&:A6>>B?/=:<&><%<3@=@8>-B5>=;?=5+;5=@>A;<=?.6<::&99@(<>=<):>4>@-<;56=7*@$>@@>/A>8%.2=:@657@939:=6<34>@A7?A>A9@@@'>@??6=87BB>20A9;?@+@@AAB4@?@@B?.4@;B524=5@6<.>92277@/9:<9BCBB<7:<4AAA>8&C<=A=89=231>8<=-5;@C7<-;7A=C7C4;@A5>?A>8<0?<@'<:;6C<=>?,A@=?B;458<87>7>>74=(?6C1AA4C>6:63$;?:>=>=*/8:4=93,BB-?77;:5?29/=?0?B>8<@B<75;B==?)828=,93:??6CCC1A=2;.;1@4><<::+>@=4ACC=CB@:6BA;5;<2<-<:;4;34'8;.'@<7?<56@7C=>?B>>AB>A@<0078039<42@;?>7(;):BB>=>:B7?5.?075CA?A:A5=?<5=>/@B1;.9?6B?;;(>$8??6867;?B?;A9388=7>?2=:81.<:<'7:98-3059;1)3-::A>A+>?>82=681:'>?@>A8>-<=.@@>8A8&=A===.45A;@?-$'76@??A??+A=:?A?3>6A=<<3634'<%764-:;>;<54%&79?8B>?@7:>2><7<5:<&468<@,:<5A4<99<&?C;;=76;(7;0@:@=:;=)23>?(9=A56#9<;-28/-9<5;=@BA5@2;A9;B@A@9A?53>0-#0898C6BB<%:+?>,;:.@*22C6?B;527<8<<>&<:;?';?BA?5=?>5=.=;?9=:1A47;>+;>8B:CC5A==>>7.AC=&3A>(149':A@>5>:%::;;/8>;8><><7=9><6BB=/;A9>AA@0?6;6>6>848#/$%@&B?A8@6:7A:=53867;,<679>)/=-4?3=:1C9A3<@@<1@@B=:,A>?=B58??890=<42<<;$*>=?=0<::?<-:05?=<;<:6<1=9):7;%.:;A6?6@A+7061>.8??%3'<@@*4C19:3<6??9(2-9@=@>=6@5B>@98@>;6-:::>8@BBA-B?+??<-A@@=C;6?8>?88,5;#%74,879=.=6.0@?4B72A6B@AA;8<7@>?4C@?<&82=&56>@AA0;.@@1AB==92:-42515:98+;@B-AC1-B=>=)3=;?;'495=<4<9'7B>6>@6@7-'B>?:':;@6*>%<;AC9>8<@/<87165?@332'7B@@;8BC3=?9596.B@&4>B/>9@7;3@'*C1@,B=@,=+/;88?A*<7&205@AC48C==3@:A>=7+:=8>>;>0;<):(*4A<@@7>6;%;?;8:97;=;?:6/=(88)9828894$*9;>/254A@556>@/:;;==2;(384?;CA7ABC8B9?787-.'<=><:8'41A@4<:A@;'1@824;+93=?5.9?25>>(<:?B<4@;86=:;7:)9?<61006>0<>CC=<@?0:873:8<9?3,B,@A59<68;9(?<6<7?=><,9?=:;>/<><=->7A:0C@AC3;>6A0A6=<0B>7:<:::<@(/C;@;=7BB?A=@@C?=-89<<>.176@>B69@<7>9+:>@C;9=7C?>:&9<7<(795=.;3:;<;6:C5@BA==A@7??@9BA<194(:;?%=(=895>A,@/@B9=,749>1(9/;B;,<:?B=>;5>?3=8BCC84;?*8AA6>A=>>@(9>:>AB>&>=9?CB=BB=@)@1>A?A8@2@?<<>7>=9>>@B2:979(<1<;3>?8@793CBA3>B=>(>BC:648;<4:':@=6&55<+A?0:CCB.6:<+?C=->C:/7;?);?>>A<>)>>A@:=18=7?>>@<&B7=7=?B=57@AC @rCer/391/2103_58_CCS ATGGGCGGACACTGAACGGTTGATCGGTGACGCTGCAAAGAATCAAGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAGCATTGGCCCTTCATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATATAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTATCCTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTATCTTGGGAAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTATTTTAATGACTCTCAGCGTCAGGCTACAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTTATCTTTGACCTGGGAGGTGGCACTTTCGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTTAACCATTTTATTGCAGAGTTCAAGCGCAAGCATAAGAAGGACATCAGCGAGAACAAGAGAGCTGTAAGACGCCTTCGTACTGCTTGTGAACGTGCTAAGCGTACGCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGATTTCTTCAACGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAAGTCTGAAAATGTTCAAGATTTGTTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTAATGACCGTCCTTATTAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTCTATTGAAGGAGAGCGTGCCATGACCAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACGGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAAGAGAATAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTCCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACTATTGAAGAGGTTGATTAAGCCAACCCAAGTATAGGTGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAAATAACTAGTTTAGAAAT + 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@rCer/392/25_2779_CCS ATGGGGCACTGGACGGCTTCGGGCAGGGCAGATTTATATCTGCGGGGATCAGCTGACGCTCCGCATTGCAGACGCGGAGTCAGGCGGCGCTATGTACGCTCTCTTCCTCCTGGCCAGCCTCCTGGCGCGGCTCTAGCCAGCCCAGTCCTCAGAATGAAAGAATGCACCAGAGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCATCCGACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCGACAGTGAAATTCTTCCTTGTGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACATGCCACCGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCGAACATGTCTGCTTCGTGCAAGGAGATAGTGGACTCCTACCTCCTGTCATCCGGACATCATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCTCTCCAGAAGCACCTGGCAGAGCTGATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCGAGCTGGACATGACTGGGTGGTGGCCCTTCATGGCCAACATCCTCTCCTCCTCTACCCTCAGGACGGCCCCCGCAGCAAGCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGACTGCATTCAGATGGTGACCGACATCCAGACTGCTGTACGGACTAACTCCACCTTTGTCCAGGCCTTGGTGGACATGTCAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATGTGCAAGAACTATATCAGCCAGTATCTGAAATTGCTATCCAGATGATGATGCACATGCAGGATCAGCACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGAGAGGTGAAGAGATGCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAACTGGTGGAGCCCATTAAGAAGCACGAGGTCCAGCAAAGTCTGATGTTACTGTGAGGTGTGTGAATTCTCTGGTGAAGGAGGTGACCAGCTGATTGACAACACAAGACTGAGAAAGAAATACTCGACACTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGCCAGGAGGTGGTGACACGTACGGCAGCTCAATCTGTCCATCCTGCTGCAGAGGTCAGCCCTGAGCTGGTGTGCAGCATGCTGCGCTCTGCTCTGGCACGCGGCTGCCTGCGCTGACCGTTCATGTGACTCAGCCGAAGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGTTATTTGGATCGTAACCTGGAGAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCCGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCGTTCGTGTGCTTGAAAATTGGAGCCTGCCCGTCAGCCATAAGCCCTTGCTGGGAACTGAGAAGTGTGTATGGGGCCCAAGCTACTGGTGCCAGAACACAGAGACGGCAGCCAGTGCAATGCTGTCGAGCATTGCAAACGCCACATGTGGAACTAGGAGGAGGAATATTCCAGCTTGGAGAAACCGCAGCATTAGTTTTTTTCTACTTGTGTGTCTGGGAGAATGAACGCACAGATCTATTTGACTTTGTTTAAAAATAGGGCTCCCTCACCTCCCCCATTCTGTGTCCTTTGTTGTAGCATTGCTGTCTGCAAGGGAGCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGGCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTAGCCCGCCCTCGCATGGCACCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGCTTCTTGACTGGAGGCCATCAACCCTCTTGGCTGGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGCTTCTGAGGTGGCCTCCTGCCTGGTCAGGGACCCTCTCCCCTTTCCTGGCCTCTCAGCTGTACAAAGCAGCAAAACAAAGGCAGTTTTTATGAAGATTAGAAGCCGGAATAATCAGGCTTTTTAAATGATTAATTCCCGCTGTAATAGCACAGGGATTTGGAAGCAGCTGCTGGTGGCTTGGGACCCCACTGGGGCCACGGTTTCTCTGTCCTGGTTCAACTGTGATTTGGCTTTCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGTTCTGTGGGTTTGGGTGGAAGGGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCAAGGCCCCGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACGTGTCCCTGGCTGCTGAGGTGCTGCTGCGCCTGCACCCCTCCCCCGTCTCATAGAGCTCCTTTTGACCTTTCTTTTCAATAAATGTGGATGGCGAGTTCCTAGGCCTGTGCTCCTGTTAGAGGGCGGCATGCTGAGGGGTCTGCTGGGTGTGGGTTGGACGCTGGGGTGTGGGTTGGATGCTGTCTGCAGCCCACTTGGGCACCCATGCTTCTGTCTACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGATACGCAGTTGCTATAAATGGACTTTGTGAGTTTGTTTTGCACTAAGTTCTGTGATTAACAATAAAATTCTGTTAG 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@rCer/395/0_1772_CCS AGGCGCTTACGTCTCAATGCTAATCAAGCTTCTTCCTGTTGGTGAACGGCACAGCATGGTCAGCGTCTCCACACCAATCTCAGAGGTGTATGAGAGTGAGAAGGATGAGTGGATTCTGTACATGGTCTATGCTCCCAGGGACGTTCGGGATGAATTGTCAGTGTAAACTAGAAAATACATCTATTCTAGATTTTTTAACCCTTACAAGGAAAAAAAGGATGTTACCAATGAGATGGATCAGTTCATCTAATCCAGATATCCACAGTGTGTTCCCTAGGGTGTTAGGAGTTGTGTTTGTGTTTCAGCGGAAACTGGCTCAGTGAGCCGTTTCAGCTTTGGAACTTATTATTTTAATGTAGGCTAGCTTGTTTTCAGATTTTAAATTTTAAATAAATACTTTGCTTCTTAGTTGCCAATAAATACACTTCAAGTTATTTTAATGCTCTTTCTCACTAATAGGAACTTGCAATTCCAGGAGTAATTTAAAGGCTTTCAGAGAGACCTGAGTCTTCTCTTCAGGTTCACAGAACCCGCCGCCTTTTTCGGGTAGAAGTTTTCTACTAGCTAGAGAGATCTCCCTAAGAGATCTTTAGGCCTGAGTTGTGAAGCGTAACCCCCGCAAAATGCATTTGCCATCAGAGTTGCACAAATGCAGGTAAATGAGGTGTGTGTAAGAAACGCCCTGACTGTAAACTGCTGGAGGTCCCCAGCTCCTAACAGAACTACACCCAAAGTCCCCATCTGCAGGGGTAGACATTTCTGGTTTGTTCTCTAGATGTTAACAATAAAGACACCACTCAAAGGAACTTGAATAATTTATATTTTGATCTAGTTTCTTAAAGACCCTGGAGAAAGAGTGGCATTTCTTCTGTTCAGGTTTTGAGTTCAAACTGGTGCCCGTGTTGTTATGGAAGCAGCCAGAGTACCAGTGTCATTCTGGAAGACAGCGGTAGAAACCACAAATGGTGTAACTGAAAGCATTAACATTCAGACACACTCGCTTCTGCCTCTGGCTTAAAGCTATGGATGATTCACGTTGTTTTTTAATGTTAAATGTATAACTCAATATTACTGAAAAGGTTCCCACATTTTGAGTAGTAGTTGTCACTGTTAGGTCAGCCAGCCATCAGAATTCTCCCACACTAAGTGCATGTCAGTTGTGGAGAAAACATAGCAAAAAGAGCCATACGCTCTTTACAGATACTAATGTCAAGAGTTCAACCTCCTCAGTTCAACCTGTGATAAAAGACCAGTGCTTCCACTACCTGCATGGGGTTCACTTTATAATTTTCTTGGGAGTATCACAGGAAAATCACAATACACCACTTAGACCCTATGTGTAGCAGGTCACAACTTACTTACCTTGTGTGTTAGATGATGGAATACCTGTATACATTAGTGAAAGCTGTTTACTGTAACGGGAAAACCAGATTCCTTGCATCTGGGCCCTCTACCGATTGTTAAAGGAGTTCCTGTCACCTGCTCTCCCCCAGTGCATGCGTCTGTCCACCTGGCTAACTTTTATATGTGTATTTTTACATTATGTAAATTCTTAACTGGCCTGTCTCGTTTAGACTGTATACATCATATCTGACATTATTGTAACTACTGTGTGATCAGTAAGATTCCTATAAGAAATACTGCTTTTAAAAAAAAAAAAAGTAACATGCTGAGGGGTGACGATATCCCATGTGAGTGGTCACTTATTATAGGATCTTTAAACAAGTACATTTTTAATGAACTAAGTTGAATAAAGGCACAATTAAAAACTG 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S((,,(&'%'##&(*))*,'+)'%&'*+#'*'),,-*)+,('&)&'(',&$##')*&)+('&-,,1+-),./&/1&,-+,+*1001)('),-'+&,/-',&,--.+,(+#.2*)&--0,1.'-.2/(%/*(&(%)-,&'&&*.12-'-0+0)#*+0,1--111*$(+*0,)"++))//&-/*$%/'&*+#$*0-.&$.'-()-*(&-..&/.,--(%.*,0-2)'-$#")&.(+%/&*/+,.2'$$).,.,'$+-,.%0&,+*&-((11-.**&%(((.,-/2,12+-,1+(..0./0/'.,-'-+&1%+,-1/#0)&&+/1-0+$0%..%)1+&01)0%(+*&,-1/&,)*)/1/1012,,.&++1.+,+.)*+%%,,)%.*$++)(0-$$&*(/*,1-'($.-,-+0/.-*.&,'%1///01$,1))/.060(555)101145'66*14(.1%)/..2+226552-4/1)/)36*/1*0(1.-44-50./2202///01.1+/%(+.'--50*25.26%2-/)'*&-'/*-(*-,1&32'*+&)**'1-38+2.1+3011&+1/+1014424,-&325-13,$('0,77/2;&0)132/9'&054-,/4.6*586300(1488602'/25)22:9(,'1,0'+.2(44/-20$,+,43534$(',1-..-)66$1/-(,374416+6-+651,26527+03./894/(1/+52)54&1%33/,-+&83'.0+-(3/.,#*$+*,$),-/)1**,($$-,.2*554.-1-*,10+.(,-*$,&&1(/-,25.063,34/3.-+$/)-51$,//2'3-''""'0187:::75%2./*2,,41,/66502.*198-89;-<<0*;91,4/*(#5030>(;;::)77=<-<4%149:/0;;=>=0<;3:4838&4.623&$$,21524?153/3899985;?76:0:9<98?7<=1.6,,32#*2//3.7113143(35810.2/69,.11555682610)*)&2-./*,%134265:1::56-858706714:9655)53)412365:862:-91664-/19.&/+6352932/6058737(33:8305(5799:5,-+655295411740)/237.++2170,1812//33159890617717.*45905(38561-96675651*784+41556,6866485/76.10.6-+2871553.-/,//411+123.'+&.4253:628747%.46.8,9+4458,&5569:6:356:6-+&98:3,39318/3-867'3786+840-+/$-40++4)65%,+,,509635%/5697+83,%59.(765&3314-874745253(58:3::734'+/+8.7'7-&4%&*&-/+$0,0(.*$788)513192()4/4250521.-)-+8803)--)*)++)-,%.0)/670/20246)9+7698*68,47-85-,345:59+50&3.::.42152*3438:669561.-.*1652/3257702255012-3/614597:56;9)84''49//63/5'44,/37..94&++$++,8518.8673;9;,3165.4-803/5.264/.--(54&140055076654,('0...535)/0%0,-0::63/9%3+/'.(-4.17087086.%.%563$-/1226875322310757645582.976222$46566,4-/92,-,-6)7669:$:0%;6==>076'36475&45)32.2&.*/+9468188 @rCer/396/2235_77_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + IKIK?@DC8JKIDJ>KDJHEJKGEIIIHG@KJFKIKKJG@C:FKBJJHIHJFECHK8GIIGCCGJHFB>BDIF:88I(DIJHHJHJH8.JKJE;IDJJ?FJAEEKJJF@KIHGCKGEJK9K=KFIKKJBG@GGHHKJFJ;>IAKHJJGEK?KKCHG5@JBJDJIKHHC7DI4EEKAKJGGDCJ:HGFEIFHK;KHEIJGIKIJBCKKIK@FKAHJJFEFKHJCKJIIK:HIE9HFF-EC?D5FKJEHIFJ:?KKKE/@@>E9GBEDHHAID<9@AAFADGKJJJ=0EIHFC9IGJK><;:BH)I:DD>IK5JJGHKBGCFJHJE@9JDE@EIKKJKEIKCGJKHFI@IIED?BKKFJJIIIEIIHF9CE.?EJDAJIKJBJGFDIFG?DG7JDGHHAGHJDJJFD4EIG2IJGJGJKK9KJFFGEEKK2EJE@E<6>JDGJ@GHJI;CFG6BEIH9CHI:BHEFGHD;GJGJKIGACJJIKJHFKKBGHK8;C)GFAIDECBHIE?FDECFC?7F@=458535;>B;FCFEDAD?8GFE5==;81938AEFGAB<4DFBFHBBGF@:B;2;A9@=4>BF9B>>4?HIEHAFFE1@?9/A?>BAJHFIFFBA?>E3@BCACAA.<=8=@+<@?+@=84?96;829@=FD@ID?9CFB?DFFHGCB@EEDHCE8>G9ACFA>AC=H=9DI>DDDEGD:C?EIJ?=;>?-2/?HBF@BFIF>,A4G4H>G;F:CGB5BA:E:DIG?HIEHEEGEIFJIJJ8GGCG?EBH4=FDIHFF>EIGFGJBHFAEB@DABFBC>IED?AF=HCD?E@ACBAHBAAB3C?;?=:=99A:>;,<9>E7:2@9F:BD@:>/6@&><:3@BDA@==DBD=<=ADDE@BC:=7CBCDBCC:@F@>=8:76;2?;49EAAA@)@8>9;??>:BB-CE??4DB@=:>9=FF@F8EB.CCE?ADEG@EDBAF@D<66BDBBFED>=8DCD@:<@E6-8BCBEEC?6=EA=>;==51:751??7?1B:?@599)>7:>=ADCCA@145;5AA;FF;C=6A=FD.DBEAAG;?<=.D8G@:A@9:>4?B<;EA@CBD:?DFDE>A?EE?ED@D@:=DD1DEGBAFFFAE?DFBE?4>GCA>A/B=?F;E@D@@1BDD6;@?1?A>A?9B;B7:6;:9C9B8@8:6*7566:?A@>6;>7???;;63+93=@=:896<3>?9?*3/224>?@>>3>E?A79)ABBCC/799<4;8:)?;>>;?;8>6GECBEE@4A9==:7=:A<==6A@@CEEF@E=FGA?>C:DA><35=4:A34483A:2894>A@99.>=A=F?<>2>?6688>5:=8A<@@67-';2D:&5447()7:83ED:98/=:69;97>??1DC:=C9>=B.<1=;->;64:6@7C=CA=DB:@CFA@=7EBC?FBDD>D=856374;<;3:86187/BB@@>:?@DFB@:(<6DABAGE>CD?>8;8??A7B?:6@;C=C654;<6A=$8BB1B?FGG<:@CD*:A<5>>.=AEG@EBD; @rCer/397/1715_58_CCS ATGGGGGATATTCTGGTAAGTAAAGGCTGAGGACTCCTCCTTACTTTAATCCTCAGATCTAGACAACTCATGACATTTTCTTTGACCAACATAGCACATGATGAGATATCAAGGTAATTAAACTAGCATGCTTGAAAAAAAATACGTAATCTGTTTCACCTGTAACTGTTTAAGCCAATGAACTTTTCAAAATTTATGTAATATGGGACTTTTATGTAGCACTTTATGTTTTCATGCTGCTTATTGTTTTATTCTACTGAAATAAATGAATTTCAAGGTTCTCAACTTTAATTTCAAAAAATTGTTTACTGTTTTGACTATGGGAATACAAAATTTCCTATTTCAGGAGAATAAGAACTCCTTTTGTCATTTTTGGCTATGAATAAACTTTTTGGTCTCTTGAGACCACCCATTTTTATAGATCAGAATCAGAAAACAAGTAAACCTCACGCATTTGGACTCATTCGAACAAAAAACCTAGGCCAAAATACTGAAAAGCATTGTGGGGAAAAGAAAGAAAGGATCAGACTGTTACTGTGTCTATATGGAAAGAAGTAGACATAAGAGACTCCATTTTGTTCTGTATTTGAGATGCTGTTAATCTGTGACCCTACCCCCAACCTTGTCCTTGCAAGAGACATGTGCTGTGGTGACTCAAGGTTTAAAGGATTTTGGGCTGTGCAAGGTGTGCTTTGTTAAACAAGTGCCTGAAGGCAGCTTGCTGGTTAATAGTCATCACCATTCTCTTAATCTCAAGTACCCAAGGACATGCACATTGCCAAAGGTCGCAGGGACCTCTGCCTAGGAAAGCTAGGTATTGTCCAAGGTTTCTCCCAGTGTGATAGGCTGAAATATGGCCTCGTGGGAAGGGAAAGACCTGATCGTCCCCAGCCTGACACCCGTGAAGGGTCTGTGCTGAGGAGGACTAGTACAAGAGGAAAGAAGGCCTCTTGGCGGTTGTTGGCAGTTGAGATAGAGAAAAGCATCTGTCCATCTGGGCAATGGAACATCTCGGTATAAAACCCGATTGTATGTCCTGTTTACAGAGAAAGGAGAAAACCGCCTTAGGGTGAAAGGTGGGACTTGCTAGCTGCAATGCTGCTCTTTATGCACTAAAAAGGTTTATGGAGATGTTTACATATGCATATCAAGGCACAGCACTTTTCCTTAAACTTATTCATGTCACAGAGAACTTCATATGTCTTACTGCTGACTTTCTCCCTATAATGATCCTATTATCCTGCCACTTCCTTTTCTTTAAGATGGTAAAGATAATTATCAGTAAATACTAAGGGAACTCAGAGACCGGTGCCGGCGTGGGTCCTCTGTATGCTGAGCGCCGGTCCCCTGGGCCCACTTTTTCTTTCTCCATACTTTGTGTCTCATTTCTTTTCTCAAGGCTCTCATTCCACCTAACGAGAAACGCCCACAGGTGTGGAGGGGTAGGCCACCCCTTCAAAGCCTCTGTGTTTTTCTTTAATTGAAAGTATATGTAAGGTTAATGCATTTAGTGAACTTGACTAACAAAGACTAATGTGCACATTAACAGATGTACTTTTTAAGGTTTTATGGGAGGCTGTGCATTGCTCAAAACTGTTGGGAACACCTTTTGAACAGTTGCCTTCAGAACTAGTTTGAGCTGCTCAATAAAACCAGT + KJKKKK8KKKKCKKKIJKKKJKJEKBIKKKKKKKKKKHKKKKKKKKHKKKKKKKIKKKKKKJHHKBJKKKKKKKKKKKDKKI?KKKHK7KKKKKKKKKJJKKKKJHJJKKKIKGKKKKIKKIKK@HHGIJBK3JKKKKKKK$KIIKJKKKKKKKKKKJKJKKGKKIKKFKHK6JJKKFJKKDKAKKKKKKKGD&H:JJKDBKKKKKK>KKKEJKKK2KEFJIJEK=KKJKJKJKKAKAIKJKKAKFHJKFJKKKIKK8KFCKKKKKGKKKKJIKKGFHK=IKKJI4KFGJKKKFKKKKKHGHKDJKKIJ-KKKIHJKIFKJ@KJGKKKBKJ7@HIJAJCKHIIIFEHK>KKKKJKJJJJKDEHJIKKK)KCGII:K;JKK@KJKJEHKK=HJDKCKJKKKGKKKDJKKGIKKKKIKKKKJAIFAJ;JKHJJIHBHKJJJKKHKCKKIHKKJJKKKJCCI@KK@KGIIKK8KKIKIJCGKKJJCJJCJCFJGEKDDKFFHKKIJ;K@KKKK@K=KHKEHJKJKEJAKGJIDJFFIHC?I?CCK4ECGJJHKIGCCK;JKDKHIIIK-HJ0JKD:KKKIKA:JC8JKK8HIAFJ=KKEKIKKIIKKFK?JGJKKIKKAIJKIKKHJKKJKGJAKJJKCJIKKDFJIKIJKJK98;H&K4KCGKJEKGIKHKKEF>GF6JDJKIKKKK/IKGIKHKKFFGKKKKHKKJGKDHIKBDIKGKDKKHI;HCBK8JKKDIGGIKKJJ@JKJCJKGKKKJJKKKKKJK>KKIKK4I0KIKKKIJIJKKKDJFKJKKIKGKKCFHKKBKKJKHDKGJKKJGKI=KGJKJKKIJIF:KG@JK5FK>FAKDG@;JI2KIIKFKEKJKJKIKI7HHKFKHG5KICKHIJ8JIGKIKKHKAHKKCEKKKKKBJKIDKJK8KKIJKIBKJKDCKKBIIIKKKKCKEKKCKHKKJJGJKKK?KKKJHKKKKIKKKKJKKKKKIIKIJKJKDKGKGKJ8KKEJKJIKKI:FJJHIKHKIEKBI=JKKJJIKAKIHHJKHGKKK@KKKH/HJDHJFJKGJJJIKIJKKHKJKIJKIHK@KKJGGKK>KJKKJKIKKKGJJJJ@KCKKIIKGKK:BJKJKKKKEJKFIHAK;GKJI:KKKJKJJKKK1KJIKCKKIKKJKCKKIK?KKFKFKKKKKK;5:67666*31:32844=,;6(+:58/7<+4===98<4?:=54&75>=?986?36<7*55<0>9;9?:8>764354645675/7+>6=;=>:237<;<4.86<48-14==47<689912<1:?9?6;/8/80,79=18;65220==?8894<;3;=875899(6688<;367=-72)8=6?8<6988,5:=<7:;;>;8<9:;<>6;8)5<;18488<8?89;6;82;988>=:>;87:<<)>>:==/;6<%:=6:3<:9998:=<=;8>=44<79,<7;;:=:<90=:6729*353808443,)5=6=:;<;042).68.9<58;9><>);;7;:64*3=82752+637/=84=<=8:67:67695:=;6::;:9229<<<5991=;?>>?987=>>:;7796<;8*7.:168881936742044956;5:4::/7495+<4,.6799713726.+00240:07164843-674383(,22761*16/.*0,-/42(00633.&60/7742*30;6:865351/.2/02151&557246.0()&-23%771/.888+1567.788.00110/412.214:7/5-324693+13.74<<9570122199458839560:=2;98885940,7-5=<9561056-'142*678+146-66/1386740:65<54/791227./-+4:8-8:7:<9;19695;,4/,3274<296/.69><7-873.046.1766<987;37+)%618=>99'.877788:36><789:=0>:>>75;99>3;<<813:<.673*2(43=*62=>9890+3:994=0>:4;;<*=4,77600//2625:798>;<9;?=>,7?6>;:42:;>:=389;3>7<=;:;483=;>5:?:837=63<;5:9=?987842;:44+47;:788(>9335+446<8;6>9<>592*:918=6=<469:::=(586<9=?=;598293632372;=99581$-5783864863;;;;9619>;95:99:72293>4<;;;?585=9:6;>7<1:659398;:30;6<=<<7>?8?>98:7=;;57<;;:=97;8767:<<0<8:9<=8:=::4578?:;>59:;6;97-6*;66993728688;;7602<9=-6.+34;5=<<>931.8<2:>3=5<>48654=8:86=7;8:/576>;7;7==8868=8829/821,4457033793<06?5255-240:33=2:7;97>5>496::417676--435-+/6654:6+646:4;8=3:898=9::>;??<=5<:8>=<;=7=::613==9:8;=2987=6718499-:93(;;-=;:978>==:>::86,5<79;815992;>86>5;645?;993?=7739941=9:7:63:486*<24:303; @rCer/401/1101_56_CCS ATGGGGGACGGGCCCGGCCCGGCCCGCCTCCCGCCGTGTCGCGGCGCACGTAGGTTCCCCGACCTGACAGGTGCGCGGCCCGGGCCGGCTGGGCTCTCAGAGCCGAGACGTGGGGCCCCGACCCGGCCGCGGGGCTGGGCCCGCTCCGTCGCCCCGACCCCGCGTGGTCCGCCAACTCCCTTCTGCGCGCGGAGAGGACGGGCATTGTTCTCGGGGCCCCGGAGAGCGCGAGAGCGGCCTGAGGTGCTCCAACAGGGCCCCCGAGCAGGACTGGAGGCAGTCAGAGAAGGACCAGTGGGAGCAGCTGGCAGAAAGCAGGCGGCAGAGGGCCGAGCTGGCCAACCATCTTCGGGCAGTGCTGGAGGCCCTTTCGGAGCAAGCCCTTGTGCTGCAGAGGCGAGAGCATGAGCTGGGACTCAGCTGGTCCTGAAGCAGAAATACACTCCAGGTCCCGGAGGTACCAGTGCCCTCAGGAAACAGCTAGAAGCACAAGAATCACATCCCAGGCTTCATGAGGAGATGGCTGAGTACTGGAGGACACGCTGGCACCAGGTGGCAGTTGCCCTGAAATTTAAAGAGGAGGAATTGCAGAGACTCCAGAGGCAGAGTGGGACCTGGCCTCCCCAGCCTCAGCTTGTGGATCCAGAGCTGGGTACTGAGCCGTACTGGACCAGTGGGCCCCCTCCTGGGATCGCTGGACTTGGAGCAGAAGAATTCCTCCAGGACTGGACTGGACACACAAAACTTGGGAACTGTCAACTGCCCTGTTATTCACCTCGTGAAAAAAGCTGGATTTAAATGAGAGCGAATGGAGCTGACAATTCCCAGAAACTCGAATTGAGATGGTGAGATTTTAGTTCAGCCCAGGGCGGTCTCATGAGTGGGTGGTAAAGTTGAGCTTTGAGGTGGTCTTCAGAAGGAGAGGAATACCCTCCGCGGGCAGAGCTTCCCGGGTTCCGGGCCCTTTGGGACGTCAACACAGGTCTAGCTGCCCTTAGGCTCCTCCGCACACCCTGGTTCCAATAATAAATCCCTTTCCTCTCTG + KJJGKK'JJKK&KJGKDKKHKJKKKKKIKKKJKKJGJHEIKJKIKKKIKJIEKKKKKKKAKJKKKKKKKKHKKKKKK5KKEKK1KGKKKKKK1KKKKIJKKKKIKKIJIJKKKK;JKK8KIKKJKKKFJIJKK2IHKKDJK:KKKKKKJIIIKIBKFKKK:KIHEI:KKKKKIKAKKKKGKEEKKKKIKKKFKKKIDKKKK>GJKJKKKKKIJJHK>IKEKKJKKKKK>KKKKKKJFBHKKKKKKJKCDEHKJIK=JKKEKKJJJ7KKK4KJKJG5KHKKFKKKIJJEKI?KKJJKJJKK&=HKK?GJ@KIJKJFKKJKKHKK>KK:JJKKKKKK9KKKKJFIDCGIKHDKGAKEJHJHJHHKJKKKKHKKDJFHKKJGKGF5JHKKGGHJK@KKKKKKKK?KKJKK0IKKIIK?KKKKKKKK>KKKK9KKJKKK;FIGBJIKHKGA@EDJIKKJJJJKEE?K8KKIKKBJEKKKKKKKG>IHFIKIKK5IKBKK?KIIKJKKJ>JKKKJ;JKF<>@=HHCJKKJKGGHIJK?EKKKEDKIACH=JKKKJJJKJKKKJKJKIKKJKII:KKIJKKJCKHFKKDKBJKKJJK=FCHJFEJI1IKKKKJAKK9CKKEKKJKIKFKKKEKKKKCEK>IKK-KGHGIJKKK3KKKKHKKIKJ9KIIK;KHGEBKHF>KJJKG=KJKKKK?KKJKKJI9KK3KK7IIKAKKAKKIIK&KKGKJHFGJCKGKHKJJK/JKIJKKK?K?DKGJGKJJKCKBIIDKKFKKKKHKJK0KJ7CJK$IKK8KK6KKKKKKJK @rCer/402/2073_63_CCS ATGGGGGAGGAGGAGCGCAAGTACATCGAGGACGCCATCGGAGAGAGCGCGAAACTCATGAACCCCCTCACGAAGTTTAGCACTCCCTGGCGACGCTTCTTCACGTCTATGCCAGTCTACGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTACCTGCTGCTCATCTCCCAGCCTGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTAGGCCTGGTATCCGCTCTGCCCCATCTGGTCATGACCATCATCGTGCCCATCGGCGGCCAGATCGCGGACTTCCTGAGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTGATGAACTGCGGGGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCCAAGGGCGTGGCCATCTCCTTCCTAGTCCTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCTGGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGCATCTCCAACGGCGTGGGCACACTGTCGGGGATGGTGTGCCCCATCATCGTGGGGCCATGACTAAGCACAAGACTCGGAGGAGTGGCAGTACGTGTTCCTAATTGCCTCCCTGGTGCACTATGGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAGCCTGAGGAGATGAGCGAGGAGAAGTGTGGATTTGTTGGCCATGACCAGCTGGCTGGCAGTGACGACAGCGAAATGGAGGATGAGGCTGAGCCCCCGGGGGCACCCCTGCACCACCTCCCTCCTATGGGGCCACACACAGCACATTTCAACCCCCCAGGCCCCCACCCCCTGTCCGGGACTACTGACCATGTGCCTCCCACTGAATGGCAGTTTCCAGGACCTCCACTCCACTCATCTCTGGCCTGAGTGACAGTGTCAAGGAACCCTGCTCCTCTCCGTCCTGCCTCAGGCCTAAGAAGCACTCTCCCTTGTTCCCAGTGCTGTCAAATCCTCTTTCCTTCCCAATTGCCTCTCAGGGGTAGTGAAGCTGCAGACTGACAGTTTCAAGGATACCCAAATTCCCCTAAAGGTTCCCTCTCCACCCGTTCTGCCTCAGTGGTTTCAAATCTCTCCTTTCAGGGCTTTATTTGAATGGACAGTTCAACCTCTTACTCTCTTTTGTGGTTTTGAGGCACCCCCCCGCCCACCTCACTTTCCTTTATCTCCAGGGACTCTCAGGATAACCCTTGAGATCACTCAGCTCCCCTCTCCTTCCAGAAAAATTCAAGGTCCTCCTCTAGAAGTTTCAAATCTCTCCCAACTCTGTTCTGCATCTTCCAGATTGGTTTAACCAATCACTCCTCCCCGCCATTCCAGGGATTGATTCTCACCAGCGTTTCTGAGGGAAAATGGCGGTTTCAAGTCCCCCCTTCCTCGCCCACTTCACATCTCCCTACCAGCAGATTCTGCGAAAGCACCAAATTTCCCAAGACCCTCTTCTCCCTAGCTTAGCATAATGTCTGGGGAAACAGCCAAAATCGCAATTTTAACAATATGCCTCTCCACCCCCATGCACTTTTTCTGACATGGTTTTCAGGTCTAAATAGTGGCTGCTCAAGTCCATGAACTCAAAGGTTTGAAGCCACCACCCACTGAACTCCCGCGTGGTGGTTTCATGATGCCCCCTCCCCGATTCCTCGCACTTTATTCTCCTGGGTGGTTTCAAACTACCCTCAGTTTCTCAGTGGCCATTTGTCATGTCCCTCAGGGGCTTAATGACTCAAAATCTGGGATCCTTCCCCTCTTAGACACCCCTCTTTCAGCTTAGAATTTGGGGAACCTATAGAGAAGTCACAGAATCCCATGAAAGGGAATGGGGCAGGGGACAGGGGTGTTTCTTCCCGGTGCAGGGTTGTGTCTTTGTGTCTCTGTCTCTGTGACTGTAAATCCTGCCCTGCCCCACGCCCAATAAAAGCTTTAGTGTACAGGCT + HKKKKH5IKHKKJKKKJKKJKDKKGHIKKKFJKHKGIKIK@IKKHKKKKKKKKJKJJKJKK9KKKKBJKKKKKGKKKJ7KIJJHIK&KKKKKKKKKK@KKKIIIJKJKJHKKJKKIIIIKIIJIIIKC7JKKJKIKKKKGJKJKJKKHKKKKIHJEDEKIJKKKKKKJIKKIEFHKK>KFKFKKJBEJKK>KKKJKKFJ@IKDKKFJKJKKKKCKKKKKKKKKJKKFKIKKJKEHKKKKIKJKKKK4HJJIKEIHGKIKKIJFGKKKKKHKK.JHFKKJGIIIKKJJKHKKGAJKJKEKKKIGIBC@FKIHCJKKGKJKKHJKJJIGK?KEJKKKKKJKKJJGFHKFKKKKKIJI&HKJIK=EJJKHKDKKKJKKIJIKKKKFICKJ>?IIBKKKJJKKJKJIKJKGKKJKJIIFKBKFIKKJHCKKAJKEKJIAGKKJIKK5KKKKDJJKIJKIKKKEFJEIJIII>H8JJGHKJIKEKKKJIJKJJJFKIHKKK2JJHJJJJHJJHFJJIHCJI?JCK9CIJKJKCKJKKKIBKKK@JGKKKKGGJKKK1J@FG@3B7574-5C?39HIBF?D&:;BICIFEJIJHIIHEGFIHEIJFFJJFKEFHJJCJIHKJKKKFIH?7CJICKJI@HFFHIIKJJJJIGIKBJGIJ9JJKCHFJIIIJIBFGIH;EKIIIBGGJIIJJHIJDEJGHJ0JBKGCAIKKJJIFDK2HKKIJEIJCFH8DJEFKGIJ6IKAFJ=HJGKK9FHJKHKKIE*CJKK.H@IGG%GJDFIIH@-GHK;JKJJKIKJF:K>CJKIBDF@DE?KKKHKKDKKKIK1IKFKKKI>EGKHH0BFEHAJK:HGEKJJKKJFCDDIHHJIJK7JJJIKKGJAJGIKKGGE?J9>HCCIJJHIJIIJJHJHIJIAJGFHKFFA?JKFIJJFKKKFJIJJHK>IIII4JDDJI:IG?KCKJHIFGKFFKJKGIBJI?HKKIJJJJHGEIJEKKKK;JKK;JKFIGCBGG>JKKH?>JKIJCGHJCFHDHGJJKK:HIKDKKIEIHJAJFGJJHBH,HKK=IKHKKKJKKDKKKKFGKIIKJKJKDKKIHIJKHJHJH=KKIK@JJKKJJKBHHFJB>KKK1GIIJAKIIFEAHEGI3KJIKCJJKKIJJDJAEHJKJKIKAKKKAHJEJJHKBKEJGIIGKGJDFKIJIJFI@FI>E;JGE@5JCFJKJIKHHHKJJKKKAIECCKFKHJIK=JKGJFKH=GDKJIHHJJKJCIHKKKKCHHG3@K:H?3IJ?JHCB==KKJJ&JCKHGJHKI=IGICE:HFCB9II%HAKIIKD:C@D=JCKGGJK+JKKJ=JH:JHCHH6K9GGHC;IFKBEJKKAIGGJIJKIJKGIJ8EGJICKIFKKBIEHJCFKHHF(=CJIGHKKFDHI*HGKHHEHKG7KBGJKCABKFIJIHF%8?CHJ)D88BGF,@HKHIEFJGJIIHJ@@C @rCer/403/0_201_CCS TATTCTGTAAAAGTGACTGTTATAATTCTTTTAATTTATGTTTCAATATATATAAAAATGCATCTGTTTTGTTTTTCCCTTTTTTCTCCATAATTTTAAAAAATGAATCTGATTGTTGTCAACATATTTGTGAAGGTCTTGTGCTATAAAGGGGAACTTCCCCTAATAAAAGGGCCTTGGAAACTGCTGGGTTTCTGACTT + S$$&'$''#''$#$'',-)&/+.%)*,'%+*++0/2-11.%+)0.1(%'*(+,&,--&&-+/-011-00-+#-..-%**'/100//0,/,+*+)01.(00/.+0.12-10)),0,,10(.,1/(+,&'/.,*+1#'+))-/00.*)%,*0&(.01211/*0---101'1.,&,--2'++0,00$%%(**12),,+(-#%'+ @rCer/407/1717_84_CCS ACACACGGCTGCTTCTCATTCATTGTCTTGACAAGAGCATCCTCAGCGGGCGAGTCCCCGGCTCCTCCAGCTCCTTCCTCCTCTTCCTCCTCCTCCTCCACCTCCGGCTTTTGGGGGGTCACTGTCCTCTCTCTGCAGCAGAATGAGCCGGCAGGTGGTCCGCTCCAGCAAGTTCCGCCACGTGTTTGGACAGCCAGCCAAGGCCGACCAGTGCTATGAAGATGTGCGCGTCTCACAGACCACCTGGGACAGTGGCTTCTGTGCTGTCAACCCTAAGTTTGTGGCCCTGATCTGTGAGGCCAGTGGGGGAGGGGCCTTCCTGGTGCTGCCCCTGGCAAGACTGGACGTGTGGACAAGAATGCGCCCACGGTCTGTGGCCACACAGCCCCTGTGCTAGACATCGCCTGGTGCCCGCACAATGACAACGTCATTGCCAGTGGCTCCGAGGACTGCACAGTCATGGTGTGGGAGATCCCGGATGGGGGCCTGGTGCTGCCCCTGCGGGAGCCTGTCGTCACCCTGGAGGGCCACACCAAGCGTGTGGGCATTGTGGCCTGGCACCCCACAGCCCAGAACGTGCTGCTCAGTGCAGGTTGTGACAACGTGATCATGGTGTGGGACGTGGGCACTGGGCAGCCGTGCTGACGCTGGGCCCAGAGGTGCACCCAGACACGATCTACAGTGTGGACTGGAGCCGAGACGGAGGCCTCATTTGTACCTCCTGCCGCGACAAGCGCGTGCGCATCATTGAGCCCCGCAAATGCACCGTCGTAGCTGAGAAGGACCGTCCCCATGAGGGGACCCGGCCCGTGCGTGCGGTGTTCGTGTCAGAGGGGAAGATCCTGACCACGGCTTCAGCCGCATGAGTGAGCGGCAGGTGGCGCTGTGGGACACAAAACACCTGGAGGAGCCGCTGTCCCTGCAGGAGCTGGACACCAGCAGCGGTGTCCTGCTGCCCTTCTTCGACCCTGACACCAACATTGTCTACCTCTGTGGCAAGGGTGACAGCTCGATCCGGTACTTTGAGATCACTTCTGAGGCCCCGTTCCTGCACTATCTCTCCATGTTCAGTTCCAAGGAGTCCCAGCGGGGCATGGGCTACATGCCCAAACGTGGCCTGGAGGTGAACAAGTGTGAGATTGCCAGGTTCTACAAGCTGCACGAGCGGAGGTGTGAGCCCATTGCCATGACAGTGCCTCGAAAGTCGGACCTGTTCCAGGAGGACCTGTACCCACCCACTGCAGGGCCCGACCCTGCCCTCACGGCTGAGGAGTGGCTGGGGGGTCGGGATGCTGGGCCCCTCCTCATCTCCCTCAAGGATGGCTACGTACCCCCAAAGAGCCGGGAGCTGAGGGTCAACCGGGGCCTCGACACCGGGCGCAGGAGGGCAGCACCAGAGGCCAGTGGCACTCCCAGCTCGGATGCTGTGTCCCGGCTGGAGGAGGAGATGCGGAAGCTCCAGGCCACGGTGCAGGAGCTCCAGAAGCGCTTGGACAGGCTGGAGGAGACAGTCCAGGCCAAGTAGAGCCCCGCAGGGCCTTCAGCAGGGTCAGCCATTCACACCCATCCACTCACTCCCCATTCCCAGTCACATGGCAGATAAAAAAACATAATAAAATGGCTTTATTTTCTT + KKKKKKKKKIKJKIIKJKKKKKKKHKKKKKKKKK7KKKK9KKKKKKKKDKKKGKKKK.JK$JKJKDFKKGKKKIKKKKKKKJKKGIKKKKK9AKKGJKKKJKCKJKKKKKKKKKKKKKJJKKKIKKKKKK=JKKKKKKEKJKKKAKKKKKAKKJIGKKKK@KKKKKKKKKKKKKJKKJKKKKKKKKKKIJKKKKCKKKKKKBKIKKKKKKAKIKKJJKKKKKKKKKKJG9=IKI:=KDKKKKKKKKEKKKKKKKKKKKJKKKKKJKKKKKKKKKKKKKDKKKKJKKKKKAKKKKKKKIJKK>KJKKBKKGKJKKGDIKJK3KKKKKKDJIHKK6KKKKKJKKKKKGKJK-KKJKIFKKKJJKKJKFJKKKKHKKKGKKFKKJIKKKK:KKKHJKK=KKKFKK:KKJKKKKKKKKKKK2IKKJI@IKKKKJKKKKFKKKKKKKKBKJKBKKKKKKKJKKKKKKKKKKGKKKKKKKK@JKKHKKKKJKKKJKKGKKKKKKK>KKKKKKKKKKKKKKKKKKKKKHKKKKEKIKKKKKKIKAKKKHKKJJ?KKKKKKKKKKKKKKKKKKKKKKKJKKKKKJKKDHK6KI?HKK$KKJKJ.KKKKKKKKKJKK9KKKK?KBKKDKJKKKKKKKKKKKFKKKKKHKK=KKGKKKKKKKKKKKKKKKKKKKKEHKHKKKKKAJK2BKKKKIKKKKKKKKKKGKKKKKJKKJKKIK;KKKKKAKJAIK7KKKKKKKKKGIKI;KKKKKKKK@KK=KKKKKKKKK0KJKKKDKKKKKKKKKKKKKKKKKK,KKKK?JJKKKKKFKKJ4KKGKKKKIIKK3KJKEKKJKKKJHKKKKKKKKK+KK9IKKK@KK;KKKKKKKKHKKK=KIKKK)KKJKKKKKKKKK2KKKKKJIKK>KKKKKKIJAKKJKKKIKK-KKKKKK:KKKJKKEJKKKKKKKKKK4KAKKKKKKKKKKIKKKKKKKKKKKKKKKK8?60@8;=/@2:>B=<=6?:?2>AF:7B>D68-816;9%4+=>E>CD5B<@6):D8CD?A.>9BC4@FDF?0BAB><<.B89/0?0=:7:BD>=BH9D@E@@>>C=='BBI=HCB4DBF9HEB4@@>;<=(=B*;(AF82B5071-/;AEAG<CE7F;A6EDH4EFGICIAG9HH?EFF?IC@BE>;$BDI?H>JAIFGF?EE6G@C&83H3:G=E?D,A9BCDBF08?G:7BG3F0?>C=$=?<3<E:?EC6G7BE%(+DGF3?F@%9;CDED<(@F7=EGGGF>J>IH?CEDDF9E;DGFJ@E@1FDI5A-FFGEDDG>G5GF<=F/C>DCGD1;1>:6;EACGB=>DFCA@3HJB@?0CDDD8EGC=C(-@B7??D@EA(=B%HJEI/DAE3=BCH2ACIB8BBDH@BE7>DJ5HHEGE0G6@D.EFE:C6F6CIDHJ?EF=C6?HGIHD=?EFFE7GGHI;GIAGDECIEA;DBCDF.96I3BBFH;?>EF5IHCHFG;IJGBGD7JIEGD@E5HFEDEGF@;A<9H9EEB4,?CA6%88?=>@;B8FCB=4;D@4BA?ACBC9(@=.<:9/5056<>;969<@#-.=>A3A=>?-683+@735)8'00;:79:?=?;&;9/;>A54)<9520::%=C@2;;(:6;8'7=7@;96503:55<95:4;0;:>>/<4:?7@A6<3ABA=B=4$:9?@76548>=A6@/46/8(6.=><(<5,:'<5/B689;,@;@,A9ACC81:@3A>4/>.<:=;066--@<:;?:8CCA:?<=<62+78?1:4>7B>9@)&'+B3<@=;)9-5;=>0+20,2-0843?488<>@08>B@=)>B?016;>;@9+:=0=<7/98:63<9,<@7788*?:C:9;<;/2&;=68@?.>C?=3;82185;4838)@2>;BC6:>99&3><0775/A@;)442;(<=>>C>;'?6:(683,26762:95<88=;4:A;<9';7;,85=,/1,).)/<;@C7)5A3C:26:>=3;$<@?2@4A=A=;890%3?@96A;80?>:06692757)),;0.=>:;7A690@?:0A5;>-?@;GA@/CAB+<;86=@C7<8@*;A@CF);:7:967537)555:06765.2-7-,6355+66+5&/02599918794184.432-7:;423/'312/ @rCer/410/1937_61_CCS ATGGGGCTCTCTGCGCTGCTGTAGCCGGACCCTTTGCCTTCGCCACTGCTCAGCGTCTGCACATCCCTACATGGCTAAAACAGCAATGGCCTACAAGGAAAAAATGAAGGAGCTGTCCATGCTGTCACTGATCTGCTCTTGCTTTTACCCGGAACCTCGCAACATCAACATCTATACTTATGATGATATGGAAGTGAAGCAAATCAACAAACGTGCCTCTGGCCAGCTTTTGAGCTGATCTTGAAGCCACCATCTCCTATCTCAGAGCCCCACGAACTTTAGCTTCTCCAAAGAAGAAAGACTGTCTCTGGAGGAGATCCAGAAGAAACTGGAGGCTGCAGAGGAAAGAAGAAAGTCTCAGGAGGCCAGGTGCTGAAACAATTGGCAGAGAAGAGGGAACACGAGCGAGAAGTCCTTCAGAAGGCTTTGGAGGAGAACAACAACTTCAGCAAGATGGCGGAGGAAAAGCTGATCCTGAAATGGAACAAATTAAGGAAAACCGTGAGGCTAATCTAGCTGCTATTATTGAACGTCTGCAGGAAAAGGAGAGGCATGCTGCGGAGGTGCGCAGGAACAAGGAACTCCAGGTTGAACTCTGGCTGAAGCAAGGGAGGGTCTGGCACGCCCACAATAGTAAATCCCCCTGCCTATATTATAATGGATCATGCGATATCAGGATGGGGAATGTATGACATGGTTTAAAAAGAACTCATTATAAAAAAAAAAAAAAACAGAATCAAAAATTTAAAAAAATCAATGCGGTCTCTTTGCAGAATGTTTTGCTTGATGTTTAAAAAATACCTTGGATCTTATTTTGTAAATACTTACATTTTTGTTAAAAAATACAAGTATTGCATTATGCAAGTTATTTCATATCTTACATGTCCTGTAACAGGCTTTTGATGTTGTGTCTTTCCACTCAAATGAATTTGCTAGGTCTGTTCTTTTTGAAGCTCCCCATGTCTAACTCCATTCCAAAAGAAAAATGAGGTCAGTAGACAGTCTATGGTGCTAGAAACCCACCATTGCCTAATGACCTAGAAGGCTTTGTTATCTCTGAGCTTGACTAAGACCATACCTAGATCACAGGTATTATGACTCCACATGAACCTTCACATTTGTTCGCTCATAATCTACTTACTGCCTAAAAACTACAAAACCAGGCTAAGAAACACCACCAGTTAGAGCATTTACTTCTGCTTCTCCTGGATTATGTGCTACAAATGTGCTTTGACTTTAGAAAGGGATGGATGAGAAGACAGATCTGAGACCAATCTGGGTAGAAGCAAAAAGTTGAACCTTTGAAAGTGCTGAACACAAATCCAAATTCGAATGGTTCAAGTAGCCGTGAAATCGCTCTTCATAAAGTGGGCTTAATTCTCTAGTTTAAGTTCTTTTGATGGAATGAATTAATTAATGTGTCAGGTGGCTTATTTGTGGATGCCATGATTGATGATGTTCATTTTAAGCTCTTACCTATAGTACAAGTACATGATGCTACTGAATATTTTTCCACTTGGAAACTGTGAGCTGGTTGTTGCATTAAAACACACATACAAACAAAATCAAAAACACTGCGGACTTTCACTCAAGCTGGTCTTTCTTCCCCAGTGTAAGGCAATCCTGCCTACTAACAACACCAACAACAAAACACTCCATCTGTGAAGCTGACGCAGTTAAGGGGGCTAGGCAGGGCATTTGTGCCAACTAAGAATCACCAGATACCCAACATAAGTACCTATCGCAGTTTTGAAGTCGTTTCTCCCCAACTCCCAACTCCTGAAGGTTGCTGCCTGCATATTTACTCTTCATTAGTGCTATTTTCCTGTATGTCATTGTGAGCAAGCTGTGATTAATAAAGAATTGGAGTTCTGTG + 66435,0.643=98?7@8:21469::=:=?>;<<7224.1:5@?7(384%5?5;3@9@1B=@AC4@C6C7;67=192@B@@A2<;@8?<<872<6?2593:=<<8<529:1436542=2@7:5=*@;>:??;7>9=>7;<2?>??:5;65=:698837639/.55059C7?5;66B86;B;27=<538=(698>:8<>==/B?9$=?9@4924<6>4@2;<<<7<@406.:;97A8?8511A?6%8B@91848?5:>;,.359/?C:;>=(92+;;759=A;6:@18389@>?;B3,=;$=77788,<9?>==9>:C<2894;?A4?A=:=@48(.63:>>8>>745<6=29605389/,<8:@5B56;=>6:>;66?@;:<:G:BB=?7>9@:<9B>85>8)BF6/BCDCB=;/;>;BBEC:BE6:;>,B9:=92:*@=?A4A+?5B>C>??A&C5>:;9=5=13(=;CGDB>18=0=,>>@E=;:8&;+5;9>8:68D>:C@<>B8+965@:;?7;.>EEG:>08??7EB;E3=?)B9=>>2.BFB=CHCB2FA@BG=5AD?0;3EGAE=EBHJC3=?A7?D;=3/90;?B<@?;@=>DGBHCC8AHG*B>==.:J>HABBGA09AD?8?8CD1GFH=):B?D<)EFBE2?7=@AA?@DD=BB6,05,HIG:=F@B,==,DA.BI?BEEHJBFHIJI47E9@5DDDD2:A;D3G@=;D=4>H>E?FFD?>>DDC7AGBD4DB>6DIA<>DC859*>HCBC;HB;?B9BD97A5AE9>D8@98H=@@8<>CBBJFBEG9@GBDDGB1HBFCAJ9<@HAE>?DD<;8>4;>0A43:-<>-=7;=7=8@5F;=+43ACBB@E@FD0>9<>?;3B<66IDA@D9G9EF?BBG@-FGCFA<;;8BC?/ABH8C8D<1A@=@7=G:GCCBA'6B?./:<.A63:AA/FBDDGC+>H?=I8DBGGGFCA0D=EC=8B2A6EEE6>G4=C;IB@DGIED@@?HF;D@5A?<:FDGJDEIHEED<&;/0<@)F=@>AGD4=2EF@?=>F+FGHIA90<>EGD7@:;1>2:CGDFHC?/=>9@A45@C=CCAGC,@;FB@AE6DD6?7A>?;B@;7:24;DAADI@?F.B>C?F:A8AD6B<>@B?DDD<@D=AH:BF=HAEFE94??HH8BC@?DJ<@;DG?F@HH<D/:=<$FGCCF:CE>;@B@*(91+78B=);=;;E9;FBE;76HBB1>=9A=ED=7:AJJ)=GBG?B>6;+<9FB:8;@GC/=4C?BIDBDBA=AC;=GCCDC?A/BAIGG9>@;-;98;@5B6AAGG6B8AEDA7>IDH2C9AFB@B,@G??HE;?8H>;:AF;EDB<;.GFAIG @rCer/411/1871_59_CCS GCATCGCGCACTGGGGCTCCGGGCGGCTGGGACCGGCCTGGGGTAGCTGCGCAGCAGGTGGGTCGGTCCCGGGGCCGCAGCGCGGGGGTCAGGGAACGACCCCGTCGGGGCAGACGGTCTGTGGGTTCTGGCACCATCTGAGCCCCCTGGCAATCCCTGGCACCTCTGCTTTGGAGCCACCTTGTCCCCGGTTAGACAGTGTCGCATTTTCCAGTGCCGTTTTGGAAAGATGCTGCCTTTGGAGAAGGCATTTGCCTCCCCCAGGAGCTCCCCAACCCCCCTGGATCTGCCCACGCCAGGGTCAGCAGCCGGAGCCCAGCAGGAAGAACCCGAGACCATCCCTGAGAGGACCCCTGCTGACCTGGAGTTCTCCCGCCTGCGTTTCCGAGAATTTGTCTACCAGGAGGCTGCCGGGCCCCACCAGACCCTGGCCCGCCTGCATGAGCTGTGCCGCCAGTGGCTGATGCCTGAGGCGCGCTCCAAGGAGCAGATGCTGGAGCTGCTGGTGCTGGAGCAGTTCCTGGGCATTCTGCCTGATAAGGTCCGGCCCTGGGTGGTGGCACAGTACCCTGAGAGCTGCAAGAAGGCAGCCTCCCTGGTGGAGGGCCTCGCTGATGTCCTGGACGAGCCAGGGATGCTGCTGGGCTCCCCTGCGGGCTCATCCTCAATTCTTAGTGATGGAGTGTACGAGAGGCACATGGACCCTCTGCTGCTACCAGGCGAGTTCGAGAGCCCCAGCCAGGCCCGCGGAGCTGGGGAGATCCCAGCACCTTCTGAGACACGTGAGTGCCCAGCCAGCCTGGCAGCCTCTGCTGGGCCTTAGGTGGTGGGCAGAGGCCTGTGGTTGGGAGAGGGCAGGAGAGCAGCCAGGGAGTCAGGGGCCCCATGGTCCACGCTATCATTGGGACATCCTCCTGTAGTTCTTCTGAATGTTAGACATTGTTTATTAAATTAGTCTTCAGAGATTATGCAGATAATCCATACTTGCCACAAATAGTGAAAAAGCATCAATACATAAAGAAAAGAATCTCCCAACCCCCCACCATGCACCCTCTGAAAATAAAGGGTCTCAAGTGTCCTGATGCAAGTCCCTCATGTCTCCCTGCACATCACACATGCACATTCAGGGCCTGGGGTCGGGCTCCCTGTGTATGGTGTGCTGTGTCTGAGTGCTTGCTGTTCAGATGGGGTGGGTCCTCCAGGCTGTGGTTGGGTCTGGTTCTTTAGTTGCCCAGCATCACGTGCTTAGCCCATCTCCATCCTAGAGGTGGACTCTCTGCCCCTTGGAGTGAAGCTGCCAGACACCTCCTGACTTGTGTGCCCCATATGTGAGGCTCTGGGCACTGTGGGTGGGCTCCTCAGGACCGCTGGGCAAATGGTGTGTGAGTTCGACATTTCACATAAAATAGAAACTTCCATGTGGTTTTCCAGAAGTTTTGTGGCTGTTCATTACCAGCATGGGAGGCGACCACTGGCCTGGATACAGCCCAGCACTATGTGGTGTTGCTTTTTAGGATTTCCACGAAGGCCAGGCACGGTGCCTCATGCCTGTAATCGCAGCACTTTGGGAGGGCAAGGCAGGCAGATCACTTGAGCCCAGGCATTCGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTACAAAAAATACAAAAATTAGCCGGGTGTGCACTTGTAGTCCCACCTACTTGGGAGGCTAAGGTGCGAGGATCGCTTGAGTCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTTTAAAAAACAAAC + 2D?HCHIICIFFGAI,DCIFGI=IJ@BEHE:;F:E@JFHHGI>G8AB0>ABFD=?6?>CEH8DEE@?HI@C?J8JHHIHHHIGJHHFBICDHH?F9EH?EDF@IHGGDF7IED?6HFGIEDCF@;IAD>JHFHFHE?B?FF5B=A?+BC;=C8@=G6?FCEFJA>>EGEBFCFFEGJDIHDF>IFCAE2@6FCDDA?D?56C6EADBBC6HDEDGEC.GG7BCG=IBEAGFFAECCBA@<==>?87AAEFCIFIHHF?@EFFD3J=GIBJJHC@DHHBE:AF?@ACAFD3;6GCH?ACAJDD>-FE?4:<3>GCGGFHI?GGFIFEC==C?IG@H?IHCD:?@=>CDGCHHG;EHH9EGHH6E8@FDIGCE7JGGAFG>E>BGEDD@F>>0?7FDCEGDFDF=CFHG@FB@CJ,CI7JHBEJA>?G/FHEJJDGJECID?H;JIDIGFFIFJIF;H7FECIABHHA@@7DG8E2G+C:EHKJIKJIHHKJB6?EKCCKHJK:CGEFBIIEJKG?@HIFKEBGIGHGFKCKDJ@@BBHB@CDEIGGKJJJDK?AJJJKJKIF0GJGJJIJKJJHEHCI?CDDGFFEEIJGFKEKJGIHJCJHKCIKIJJJKBHDEHJKKKK5JJGHEG6IIJGGHJ>JKKJHJI=AEFFIFAAJKI3KGKKAF@GI;GFEKEIDC?JJKGGJKGFJKKKIJF@JJAJGHJJ?DHHBCKKI:JJKBEKCIE>GIIIJCKHHH?KI=CGAKIKGIJH:HJJJJAIKCKIJII6IJ=@>JD;IHGHIBHEIFIGIIKI0GIGEGH/;GE1GKBKIIGIHIIJKKKIGJ:CFKKIFKH2EAHFGDGIFH>?GKHKKKIHK=JD>HKKGDEJKIH1FIJKKHFIJJKKD7;HIIKIJ8JFGK66JKFCAHHH;HI7=;3.+6>2?<560*47;:88,4:6144%*$9<68/8.>6>?=193;8=8::1,32%=1189323=68->:26,7:95628:.::;99397*99499:75221%289'739::600,--1+42%473& @rCer/416/0_1500_CCS CTGTGGCTGCTGATCCTGGCCCGCGATCACAGCGCCACCGGCCGCGCGCTACTGCACCTCGCCCGCAGCTGCCAGTCTCCCGCTCGTAACGCCAGGCCTTGCCCCTGGCCGCTTCTGCGCGCCGCAGACCCATCGGACGCAACCTTATTCGCAACCCTGCGCCAAGAAGGCCTCCGAAAGTGGATGGTGCAGCACGGTGGGGACGGCTGGGTGGTGGAGGAAAACAGGACAACCGTGCCTGGCCCTTCTCAGACGTGCTTCGTGACCTCATTCAGCTGGTGTCGCAAGAAGCAGGTCTTGGACCTAGAGGAGGAGGGTCTGTGGCCAGAACTGCTGGATAGTGCAGGATTGAGATTTGTGTCTCTGACTGTGGGGAGCCCGACACGACAGTGGCTGTATGTATAGACTACTTGTCCAACTTCTAGACGCCAACCGACTGTTCTAGATAAATTCTCTGCTGTGCCTGATCCCATCCACAGTGGAACAACAATGCTGCCTTCACGTCACCCACGTGTTCTCCAACATCAAGATGGGCATCCGCTTTGTGTCTTTCGAACACTGGGGCCAGGACACACAGTTCTGGGCTGGCCACTATGGAGCCCGTGTGACCAACTCCAGTGTGATCGTGCGAGTCCATCTGTCCTAGTCCAGGACTATCCTTCTTGCAAGACAGCCTGACTGTGCCTTCCAGGGCCCGGACCATTGGCTGGGACTCACCATTAACCAATTGACCACTTGTACTCCCTGGCATACTGAGAATTCCTGGGTCCAATCAAAGGCCCTGACGGGCCCCGTCTTCAGGTTCTAGAAACTACCAGAAGAAGCTTCTTCCATCTTATCTACCTACTGTAGCTGCTGCTTTGGGGGGGCCTACTCTACTGAGGGAACCCACAGGTGAGCCTGGGGAACGCCCATCTTGGAGAAGAATTCTCGCCCTCCCCTTCTTCTCTTCCACCCAAAACCCTCCGATCAGCCCCAGACCCCTCTGTCCCATCCCTCCCCTCCCCGCCATTGACCTCTTGTCTCCTATTGTTTCTGCCATAGGGACTTCTTTGGTCCCTTCAGAGAAGCCCTCTACTCGTCTCTGAACTTAGAGCCTCATCCTTAGGGCTCAGAAAGTCCTAGCCCTAAGGGTGCGAACCTCACCTCCTGGGCTTCCGAGCTGCAGGGCTGGGACCAGGTCATGCAGCTGAAAATCCACGTTAAAAAAAAAAAGTCTGGGCCGAGCACAGTGCCTCATGCCTGTAATCCCAGCATTTTGGGAGGCCAGGGCAGGCGGATCGCCTGAGGTCAGGAGTTCGGACCAGCCTGGCCAACGTGGTGAAGCCTCGTCTCTACTAAAAATCCAAAAAATTAGCCGGGTATGATGGTGGGCGCCTGTGATTTCCAGCTACTCAGGAGGCTGATGTAGGAGAGTCGCTTGAGCCTGGGGGGCGGGGGCTGCGGTGAGCCGGGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGT + S,--1211.++(&+$.).1%//-1226500254656/.3-3)036555.*,0'%,*)./-4265264/14&),-4-//042652121/6*2265,226)1##350*.2*555/40212213%-13/450664(1%315,522031/0&0-...,',5-*0$-1065,4(0(2/.02266665624&0'25+2265,31*1241/$-03/66.&2-'4)36)34442)0*)*-)..+,%-/%3&02130105501512,$214040*5/4.464-0(/)024-300%.3-400.*33/)5,0.-44//0%+1.51*34/2/0+)4(5'()540420/4021++)&*)0/-1001%166233150/)0002*/-30/*0135144100.4+10+40./42+//.&-+04541+75/*4(5299::4.367+2+849+5:25.645-+40/366:926,857:9039/3/5%7749+9554/*28,1345)7:90$360:7;:6/95,3&259+772,78:::5:::::7:18,-69854,838(7352346,7825396241,556-:37737602764-5/-(96173:/68.9:754:6)97443564-91838:;:0)-46.099.35773-48645-33,7412(468'/05394009760:651515:707;8.34:981-72:,33+:8/60$613:528/95:.764/7902:95;%4'71:4:4-.6367:91.$*-.77-88:9295664-2.7'47*775*93:9729:69,::.:9:*52$5/-35/-822(4.69526&38582451/-::09:41=>;?5>:8:%85-+087>34<<;9=>-8<996=,==';<<;869?3==<=02=7;.*>;6;+=9;64:?=7<74:7*2-92952,77247.7398;<>38>2>2<9<15>;(;:1$#0+)9288<)>5&78/:=;4??86=><4)7<*==96:3%65378:;3%3797/9=5(<<99$34488?52:<=5?>1)=>:<<:<>92?=+=932<&88=>-::=07<>==?4>9:82;1=69??;897=9<69<,<>97>909=:<:=?77==4:3=:=5;>526944/3??,55<>=8<6.6=<>::>>>=274???23;93;6;%988<<;<:876<:=8;=4=;6*8:;=99:9?><=<=3<>?>4:,&53039>2???+7194>7=8(24:7.29,;;96489>>82=8:38:86:?;$362>28.423?'*+:7312::>9?8/832<:8:::28:$;958;9:(:<<;9:;8<:?3??1/21507;79?;:>7:<;8;77==4<><9:79:;9837225:;2;<938>8==99:5>:?=562;<+9;<786,:89:788=2688>>7;8>>78;9?>>??;2844;=;36<(45'34<2<7=>99<998;<6;84< @rCer/417/1691_58_CCS ATGGGGCAGTTGTGCAGCAGAGGAGACTGCAGACTTCGGTGAGGAAACGGTATTTCATGTCTCAGGGAGTAGATTGTGCAGTTACAGCTTTTCTTTGGTATGCATAATTAATAATGGAGCTGCAAAGCAGATCGTGACAAGAGATGGACGGTCAGAAGAAATTGGAGGACAAGGTTGTTGACCTCTCTACTGGAGAGACATGAGAAGACTGGAGTGGTGTTTGGTGCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGTGTAACAGCCTACATTGCCTTGGCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAGGGTGTGATCCAAGCTATCCAGAAATCAGTGAAGGCCACCATTCAGGGCATATCTGGAATCTGAAGTTGCGATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTAGTTGATTCTCTGAAGTTGCAGTGTTGATTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACGCTACTGATTTTGGCTCTCATTTCACTCTCAGTGTTCCTGTTATTTATGAACGGATCAGGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAATCCAAGCGAAAATCCCTGGATTGAAGCGCAAAGCTGAATGAAAACACCCAAAATAATTACTAGGAGTTCATCTTTAAAGGGGTATTCATTTGTATATGGGGAGGTCAGGAAGAACGAACCTTGACATTGCAGTGCAGTTTCACAGATCGTTGTTAATCTTTATTTTAGCCATGCACTGTTGTGAGGAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTAAGTATTGTAAGCTGCTATGTATGGATTTAACCGTAATCATATCTTTTCCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTACTTTGTTGCAGGTAGTCTTGCTGCATCTTGGCAAGTTGCAGAGATGGTGGAGTTAGAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAATGTTTAGACGAGATCATACCAGTAAAGCAGGAATGGAAAATCTTGCTTTTCTGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGTAATATAGATTATATATATAGTGTTCACAAGCTTAGACCTTACCTTCCAGCCACCCACAGTGCTTGTATTTCAGAGTCATGGTTATACATGTATAGTTCCAAAGCACATAAGCTAGAAAAAGAAAATACATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATAATTTCATTGCACAGACTTCCTGTAGTTAATTTTGTCACAAATCAACTCTATGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGCAATATCAAACATTGTTATGCAAGAAATTACAAATGAAGATTATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAGCAAAGTATCAATAAAGCTTATAGAC 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@rCer/425/0_875_CCS CAGTGTTAATAGACCAGTGTGACAGATCACTTATCTTTGTGGATTGTGCTTAATACTGATTCAGTACTGATTTAATACCTGACTTCAAAACTGACATCTGTTGTCTGTGATAACACTTCTGTATTGTGTCTAACCACTTCTGTATTGTGTGGTCTTAACTACCTAAGGCGGCAGCGGCAGTGGACTCCTTCCTTAGGATGGGATCAACTCAATTCAACAAGATTTATAGACATTTACTATGTGCTAAGCATTTGGAAGACCAAGCTACAAAGATAGACATAGTTCCTGCCCTCCAGGCAGCAGAGGAGCACAAATACCAGGAATCTCTGATGGGTGTAAAGTGCGGTGGTGGCCACAGAAAATGACCATCATGGAGACCCTGTCAAAGTTCCGACCTGAGCCAAAGGGTATTCAGAAGTGGAGATGATTTTGGTCCCACTCATAGATGGGTGGCAAATCTAGGATTGTATAAAGCATATGAAAGTAGGGTGATCACCCCGAGGCAGAGGGCCAGCATTTGCAAAGGCACAGAGATAAGAGGAGCAGGGCAAAGAAAGGAGAGCAGGGAAGGTGTGGAGACGAATCTCAAAGCTAAGTAGTGGAAGCTGTGCACAGTGCTCACGCCTGTAATCCAGCACTTTGGGAGCCAAGGCTGAGGATCACTGGAGCCCAGGAGTTTTATATCAGCCTGGACAACATAGCAAGACCTTACCTCTGCTAAAAATTAAAAAAAAAAATTAGTTGGGTGTGGTGGGCATGCTGTGATCCAGCTACTCAGGAGGCTGAGGTGGGAGGATTGCTAGAGCCCAGGAAGCCAAGGTACAGTGAGCCGTGATCATGCTGCTGCACTCCAATCTGGTGACATGAGCCATGTC + F>5??.EAFD<;,'A<4BB<>F3?GGF9D:DJBIH%A>5>/JG.HBA;D=E(AGD9?FJDA?3H=BECII+JG(EIF+3.GG*=JA/JKGG;G=K=I@GJCKBJIA2ECGDBB$@6DKFAHBF1KGHG?5$:J6HE&5*(+?D20JKDJ?>8BH%5D@8;9F1F6B=H%KK:$>@>=(D73853*>A9FA=8HKKH*@9'H0K+BHKHF%I5AD1JG5E-HFHI7IBI8DH@HKKK/KKK'KH0KKHHEJFK?DD5#@@E3JD8KKKJHKAKK(KHGAH@KKF7A;J:C*IJCJK9KKKHIJJJ?KKK5H1IFIIG)KK6K?IAI.IJIJ?KK(KKHGHKJEFK?KEJ3K93JJCKKJ(JIJ+KK4KKE6>%H4KK@J)=)7;)G/>.B??KI@EI.KKEIHGKF9:6H9K7KIJGFEGJKJJE556C6HKK$JA8;AKB6KJHI83;KK/KI/);J9K+KDA'D8FFJ?KD(.KJF8KKK7KGI1KKIB61FIAF0K65GC/'I=;G@EI1KDE8K@JH8HFKEJK21HHIK75$EJIJFE>III9H<5EK&HECE?8JI1IC8KKIJI)IG'JH?>KE.K>HJKJIG)GIJ3K8K?7J;@-DFIGJIKGD>*@1FEJK>AEAI3HB:CGJGI@K*HC>:+GCIHD'?HIH9J>BFK= @rCer/428/0_347_CCS TATCTATACCTTTGTAACACAGTTGAGATGGGAACTGTTTGGGTTTAGGGCGTCTTAGAGTTGATTGGATGGAAAAAGACAGGAACTGGTGGGAGGTCAAGTGGGGAAGTTGGTGAATGTGGAATAACTTACCCTTGTGCCTCCACTTAAACCAGATGTGTTGCAGCTTTCCTTGACATGCAGGATCTACTTTAATTCCACACTCTCATGAATAAATTGAATAAAAGGAGATGTTTTGGCACCTGACATAATTCTGCCAGGCTATATGACAGTAGGAAGGAATGATTTCCCTAACAAGCCAATGCACTGGTCTGACTTTATAAATTATTTAATAAAATGAACTTTAC + S))'-),)'))'(#"!"#+*++')(%#&(),+&'$'#+-($+,)-()()&$''%&&$%(($(#&#(#(($%&""&##$##'%)%'&&((#&)($'))+)-',((,+,,)'+(-,)'++-'+-(*'')')+)(.-(+%*)#*+)+''()%&(,-&*&##))*+**)'((.-()#$((%$&*&#$()*'')*',,%)',+.,,-)')))*-+(&$(&#(+-('&'$,'%#,*#$##%#%&+(**,+**%('(*#$()-,*+('%(''')')-+**$,.+-(-%(++,&(%',,*)-,)+)+,+(**,)'*)*+%)&++-*-*-(+)-,',.-**(&)*,(+((-'#)+) @rCer/429/2666_57_CCS ATGGGGGCGGGGACCCGGATGTGTGTGGCGGCGGCGGCCGAAGAGCTTGTGTGCGGAGCTGAGAGGCCTATGGATGAGGAGGACGCGGCGGCCCGGTTTGTTCTCATGAACAAGATGGATGACCTCAACCTGCACTACCGGTTTCTGAATTGGCGCCGGCGGATCCGGAGATTCGAGAGGTCCGAGCTTTCCGGTATCAGGAGAGGTTCAAACATATCCTTGTAGATGGAGATACTTTAAGTTACCATGGAAACTCTGGTGAAGTTGGCTGCTACGTGGCTTCTCGACCCCTGACCAAGGACAGCAATTATTTTGAGGTGTCTATTGTGGACAGTGGAGTCCGGGGCACCATTGCTGTGGGCTGGTCCCTCAGTACTACAGCTTGGATCACCAGCCTGGCTGGTTGCCTGACTCTGTAGCCTACCATGCTGATGATGGCAAGCTGTACAATGGCCGAGCCAAGGGCCGCCAGTTTGGGTCAAAGTGCAACTCCGGGACCGGATTGGCTGTGGCATTGAGCCTGTGTCGTTTGATGTGCAGACTGCCCAGATCTTCTTCACCAAAAATGGGAAGCGGGTGGGCTCTACCATCATGCCCATGTCCCCAGATGGACTGTTCCCAGCAGTGGGCATGCACTCCCTGGGTGAGGAGGTGCGGCTGCACCTCAACGCTGAGCTGGGCCGTGAGGACGACAGCGTCATGATGGTGGACAGTTACGAGGACGAATGGGGCCGGCTACATGATGTCAGAGTCTGTGGACTCTGCTGGAGTACTTAGGGAAGGGCAAAAGCATCGTGGATGTGGGGCTGGCCCAGGCCCGGCACCCACTCAGCACCCGCAGCCACTACTTCGAGGTGGAGATCGTGGACCCTGGAGAGAAATGCTACATTGCTCTGGGGCTGGCACGGAAGGACTATCCCAAGAACAGGCACCCTGGCTGGAGCAGAGGGTCCGTGGCTTATCATGCAGACGATGGAAGATCTTCCATGGCAGCGGTGTGGGGGACCCCTTTGGGCCACGCTGTTACAAAGGGGACATCATGGGCTGTGGAATCATGTTCCCCCGGGACTACATTTTGGACAGTGAGGGGGACAGTGATGACAGTTGTGACACAGTGATCCTGTCTCCGACTGCCCGGGCTGTCCGGAATGTGCGGAATGTCATGTACCTGCACCAGGAAGGGGAAGAGGAAGAGGAGGAAGAGGAAGAGGAAGAGGATGGGAAGAGATAGAGCCGGAGCATGAGGGCAGGAAGGTGGTGGTTTTCTTCACTCGGAATGGCAAGATCATTGGGAAAAAAGGATGCTGTTGTTCCTTCTGGAGGCTTCTTCCCCACCATTGGAATGCTGAGCTGCGGGGAGAAAGTCAAAGTAGATCTGCACCCCTTGAGTGGCTAGGGCCTCCCCTCCAGACCTGCTTCTTCTCCCTGCCCACCCTCTGCTGGGCCAGGCACCCAGTTCCTGACTTCCCAGAGGATTCATTTACCCAGCAGGCCCCTGGAGGTGTGTAGTCACTCTGCCCCCACTGGCTCAGGCCCGTCACGCTTCTCTGTGCCCACGTTTCTGACCTGGTGCTGCCACTGTTGTCAGTCCCTGGGCCTGAGTCCCTGGTTGGACAGGAATGGATCCAAAGAATGGTGTTGGTATGTGGGTGGTCCCACTCGCTTCGGTCGGTGGGCTTCTGGATCCCCCTTTACTTCACTGGCCCCATGTGGGTGGAGAAGCGTGAGCACCCTATCTCAGCTGCTATTTAGGCATGATGCTTTGTAGAGGTGGAGTAGACAGCCCCTCCCCTACTCACCATGGTATTTCTCCTTGAATTCCTCTTTCTTGTTTCTTTCCTGGTTGTGTGAACCAGTTGCTGCTGTCATACCCCTGGCAGGGCCAGGGGACCTCTCTTTGGTCATCTCTGTCCTTTCACTAGCTGCTGCCCCAGAAGACTCCTCTAGGCTCTCCATTCTTTCCCTTGAGAGCTGGCTCCCCACCCCAGCCTGCTCAGGCACCACAGAGAATCTGCATCTCTGGCTCCCCATAACCTGGACCCACATAGGTGGGTGCCTGTTGCATGTTTAAGAGACAGGGGCTGTGAGTGACAGGGCACTAGGACTTCGCTCCTTTTCCCTTCCATCCTTCTTTGCCAGTGCCACCCATGTCCCTAACTCCCAGGTACTGGGGCTGAGGCTCTGGGGCCTGTCTCCCTGTCAGCGTGAGGGCAACACCCCAGAGCCTCAGCCGAGCAAGCCCAGAGGGGCAGCGTGGCCTCTCCCTCCCTTTTCCTGCCCCGTCCCATGCCTCAGCTTGCTGCTTGTGCCAGTTGCTGTTTCGCTCAGTGTTTGATTCTAGCACTTACATGTGTCGTCCCCACCGAGCCCTCTATCTCCTAATCCCTCAACCCTGACCCCCTCCCCATAACAGTGACTTCTCCATGGAGGAAGAGGGAGCAGGAGCTGTTGGTCTTGGTTTGCACAGAGCGGTAGGGCTGTGGGGAAAGCGGGTGAGCTGTTGTGCTGCTGGGCCTCCCTTTGGCCCTCGCTTCCTGCCCTATGATGTATGAAATGTATGTACAGACCAGAGATGTTTATACAGCCATAAAGATGGAGTTTCCGTATTT + 939965,5653&77.*--//45+2/7/1961:5056-=6:=6;8<==982744>=713>:><388/<-/9/57861,531;;6+/277=:86;*;;860463:415:6;.8;958;;51.=6=<9=>6:0=<9;1-5:2<1:>11<;35%+84815241897379357=;965376497:7<-77=:58(32:.886:446=5=>377920)0067:?=<:3271/761.;448)<5;7,,6292>85;38(400==84558?7<=:;:<<9/99966=7931.4421)989;9<+403142:7003.65322:0<<=0492631./%69=47?8=4086;8$2964545/65941+2+3::;9=9:3;==8=>:8905>/99<492:<2>;23+:;<97/831.:3=:9:/58-478>74?:56727;=;:89/83<9.;/;85<056:<7.08=:1661699.67;676243225)5<6;8>?9=8547<;9;986:13<6885573=79/42/5;)::=4968;<38=:=;?77=2<:=22743+;<1-7,9<>01:07191626?;;7:1509;-78/59=<0:>;==<,989;1=:55<:66/=8667,0=>;8><7<=2694=?5<>/0776*47=8217<23/;2;:.=2==:7-9*<4/)486770409669502874++18.7885>9>1*3-*37=:69;<>,>745/56<7;6<8;>=;<38>:3;8:%79=8&9<=:059:395/29;2;946.:66718;;89.7796775,<6>2;?63<373,91:::58.345:6329;0=;8=>6435:=;891,5%8<34<8;:8*8+;>>3=;5430055+:9159=;:89<8/:5/1'3:?957>;2=9=50;<<978&?29?<<<:2588947?=8::.'/>:=:9;+98*9<<495*479=89>:3>>5626$1/8:<>?6=9;6=897988355898=>,;<>;+=817609,+=>758:943;89869/2983;::==1753*434*<3%/6?<;<=:(>?.<2.2=;::7'874>9>=<527<=,4/48733462742;33-89:899>65<2<93;21074>=8;8>4/8:,9::0/%,%:59465>307(6;:65:<46?;=:>68-=98;9568'31>;7&?;<>>:>?<:389:7:212;27,3858-680#02-5832;7:.2);575991568<*>:;:9-9705)39.=9?;5<29:99:956.5=6:7533==577;9041267%<7:44:86=88;2;6<<>:=84:660)/>5:??28:<43.5365736;878=>;9;9:/999>6<99<;(=80/:;;<;;985=-=8=84)=3:>7/72:9;<-4/0<;==(9=743:=:1,-1%;8>;3;88=3108$78<441>887++,74,5;699976=:719646=5<662-4;=661&35*066.<878<<<=>>9*57-772<66::28?;89>:6;09:89=405::8.8:/;8;2:63377388&:4/=3;99:;7272;88;9>:=:797,1<=067234:?6<;248<5769987;:9:/>7<2<9:47;9==:53:?==?7;?68:71>=;2<48=9332-326'5=8=8?;:88368279<9/83/6:7<9<6946:66-9?69<86=69;8;7777989.05/6:95982=<>38$4.<503/749=?<=:>:69>61=-;2;=?88:0>.6:9=579/2:8&2?<2308:9:59<=<;?:?=8=88858=<1<7<:26144%8<1=5,5+?;:::9+46,8=7489(:93:5898:9<894882><;9;>:89:4:78>578275:2/>;8<0/:(+.641+99,9<8316(3159<24;;=0/347:,253;,8.72,8=;<:4)2583<;3714553935728:1<708=69:8)6:6$;583(1696::2954554425:;85221/566.40(/-20522-/2/%,-.32,%'+446/+2440/4654$//4-2(4-.20&44(.).10)3/4-563,32*32(053565/+.6622.56/1152,04,424+(%..30102(530//43+40.*03,+.&1255/..'.41664/1%,.032)0+/,0%53.+--152062562,565556.1156630'+'3.-01,,55%)52-0*.23/-&0024)135223.364/)-)11/.('(-4,)45/.(1044'412%//56351*42512/053531/4602653012-653566301113*5462/23/-552665+20.&,2$.05421//2/14)41554*015220+.010341.+,*611156/41.24().4/564666023.,05+*0-.*+34.3&.05502055652(11#215/*+062.3520*,1656416635,/20(6656166415633.203/55)521/55033(*660532104/22+55615442032/)(5655153.%*55*1.154*/661546554/* @rCer/430/1678_60_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTT + KJKJ*CEFJGJ?CKKKJI9KEJJJKJKKKJKJ2KKKKKK;JK@IIK7KKKIKKKCKEIIFKKIGDJ=JIKKKIBKBJ6JKIHIKKKKKKKKJHKKKKKKKKKKK@K;KJHIKKKKKKKJKKKKKKJKFJJKKGJKK>EGHJHKICKHKKKKKKJK?FKKGKIKKKKK*KEKKKEKKKKIIIKKKKEEKJK@KJK4KKKKKKKKBIFKKKKKFKK2KKCJKKIKK6KKJKKKK/KKKHKKKFKKKKKKKKKKKKKJKKKKJKKKKKKKJKIKKDKIKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKJKFAKKHJKKKKJKKJKKKKKKKKKKKEKKKKK>KJJ>AC9KKKKGKKKKKIKK3JIE@KKKDKJKIJKKHKK6K>JKKJIJKKKGIKGJKKKKK@KKKKKKJKKKKKHKKKKKKIKKKKKKKKKJKKKKKKKKKDKKJJKHKKKKJKHJDIJK?KIFKKKKKKKKKKBKKKKKKKKKKKKG7>6KKIKKKI8JKFKIIJKKKK@KKKKK/GHKKKKKKKJ9KCJ@KKKJKKKKJK3KKKKKKIKK@KKKKKKK&KKKKKKKKKKJKKKKKKKKJ>JKKKKJJKBKEKKKJIJKKKFKK?KKAEKKKIKIKJKKKKKKKKKKKKKKKKIKKKKK6KKKKJKJKKDKKKKKJKJJFGKIHKKKGKKKFKKKGKKDKKJK8KKKKIKKKGKKKKKKIJ@KKKKJKKKJKKKKKDGKHKJKKKKK=KKF47JKKKKIDKKKCKCKKJKKKKKKKKKKKKKKKKKHHKDGHKKEKKKKEKKKKKHKKK:HKKCIKKKAKAJJIKKKKKKKJKJIKKAKKJKKKKKEKKKIKKKGKKJKKKKKKKKKKKKKJKKJKGKKIKKKK2KKKKKJIKCKEBKKHKKKKIKKKKKKKKKKKJKKKKKKKBKKFK@KKKKKEKKKKKKDKJKKKHKKKKJHKKJKKKKKJKFKKJKKKGJHKKKKJKKKKKJ@KKKKIJKKJKJKKJKKKHKKKK=KKKKGDBDKKKKKJGIJ>KK@KKGKGB2KKKKKKKKJJJKKKKKKKKKKCKKEKKKKKIK+KJDKJJKKHKKKKKJKKKKKKJKKKIKKKKKKKKKD9JKKKKIKKKKKAKKKKKKKKKKKKKKKKK3KKKK.KKKIKKKKKKKKKKKJJKKKKKKKKK8KKIJCKKKKK; @rCer/431/25_1859_CCS ATGGGGGACGCAAGATGGCGACGGCGACCATAGCTCTCCAGGTCAATGGCCAGCAAGGAGGGGGGTCCGAGCCGGCGGCGGCGGCGGCGGCAGTGGTGGCAGCGGGAGACAAATGGAAACCGCCACAGGCACAGACTCCATCAAGATGGAGAACGGGCAGAGCACAGCCGCCAAGCTGGGGCTGCCTCCCCTGACGCCTGAGCAGCAGGAGGCCCTTCAGAAGGCCAAGAAGTACGCCATGGAGCAGAGCATCAAGAGCGTGCTGGTGAAGCAGACCATCGCACACCAGCAGCAGCAGCTCACCAACCTGCAGATGGCAGCAGTGACAATGGGCTTTGGAGATCCTCTCTCACCTTTGCAATCGATGGCGGCTCAGCGGCAGCGGGCGCTGGCCATCATGTGCCGTGTCTACGTGGGCTCCATCTACTACGAGCTGGGGAGGACACCATCCGCCAGGCCTTTGCCCCCTTTGGTCCCATCAAGAGCATTGACATGTCCTGGGACTCTGTCACCATGAAGCACAAGGGTTTTGCCTTCGTGGAGTATGAGGTCCCTGAAGCTGCACAGCTGGCCTTGGAGCAGATGAACTCGGTGATGCTGGGGGCAGGAATATCAAGGTGGGCAGACCCAGCAACATAGGGCAGGCCCAGCCCATCATAGACCAGCTGGCTGAGGAGGCACGGGCCTTCAACCGCATCTACGTGGCCTCTGTGCACCAGGACCTCTCAGACGATGACATTAAGAGTGTGTTTGAGGCCTTTGGCAAGATCAAGTCTTGCACACTGGCCCGGGACCCCACAACTGGCAAGCACAAGGGCTATGGCTTCATTGAGTACGAGAAGGCCCAGTCGTCCCAAGATGCTGTGTCCTCCATGAACCTCTTTGATCTCGGTGGCCAGTACTTGCGGGTGGGCAAGGCCGTCACACCGCCCATGCCCCTACTCACACCGGCCACGCCTGGAGGCCTCCCACCTGCCGCTGCTGTGGCAGCTGCTGCAGCCACTGCCAAGATCACAGCTCAGGAAGCAGTGGCCGGAGCAGCAGTGTTGGGTACCCTGGGCACACCTGGACTGGTGTCCCCAGCACTGACCCTGGCCCAGCCCCTGGGGACTTTGCCCCAGGCTGTCATGGCTGCCCAGGCACCTGGAGTCATCACAGGTGTGACCCCAGCCCGTCCTCCTATTCCGGTCACCATCCCCTCAGTGGGAGTGGTGAACCCCATCCTGGCCAGCCCTCCGACGCTGGGTCTCCTGGAGCCCAAGAAGGAGAAGGAAGAAGAGGAGTTGTTTCCCGAGTCAGAGCGGCCAGAGATGCTGAGCGAGCAGGAGCACATGAGCATCTCGGGCAGCAGCGCCCGCCACATGGTGATGCAGAAGCTGCTCCGCAAACAGGAGTCCACAGTGATGGTTCTGCGCAACATGGTGGACCCCAAGGACATCGATGATGACCTGGAAGGGGAGGTGACAGAGGAGTGTGGCAAGTTCGGGGCCGTGAACCGCGTCATCATCTACCAAGAGAAACAAGGCGAGGAGGAAGATGCGGAAATCATTGTCAAGATCTTTGTGGAGTTTTCCATAGCCTCCGAGACTCATAAGGCCATCCAGGCCCTCAATGGGCGCTGGTTTGCTGGCCGCAAGGTGGTGGCTGAAGTGTACGACCAGGAGCGTTTTGATAACAGTGACCTCTCTGCGTGACATTGGCCCCTCTCCCTGGACTTGCACTTGTTCCTTGTTTCCTCTGGGTTTTATAGTGATACAGTGGTGTCCCCGGGGCCAGGCGCACTGTGCCCAGCCCGGCCTATAGTGCGGATAAAGGTGCGGATGCTGCTGGCCCT + KC,KKKKGKKI@IKDKIFIGHKJCK7KKKKKKKKKKKKKKDKKKKKKKJKJGKKDKKKKKJKKKK;CJJHJAGCKJEKFKEJKKKFKKJKIKKKKKHJGKKKIKKK&KKKDIKI7IIKKCKKKIKIDKJK@KKK)KKKJ>KKJKKAKKHKJJKKEKKKKKKKKJGKJCKK6KKHIFDJKEHIJKEJKFKKKKKFKEKH*KKKJDKKKKKKKJKIKFKHKJGKKIBHF=IKIJJ=KKJIFFKKKHIKFKKKKAKKKJJKKKKKFKGKKGKKIJKKJKKHKKKKKKKBKBKK;JHKKKGHJEIKKHJKCKKKJIJHKKKHJFJG>KKJKKHHJKKKJKKKKFKJKKKKEJIJ9KKKIKKIKGKKDKKIKKKKKBKKJKJKKKGKKKKKKEKKDKKKHKKKIJKKKKJKKAKIJKJKKGKKKKHJKKKKKKKFKKKJKJKKKJEKGKCKKIKJIJK6KKJKKK:KK?IKKIIKJKKKKKIHKKJIKKKIKKKJJJKKJKKKIKKJIKKKKKIEKK=KJJKJHKKHJIIIKGBIKKKK>KKKJKKKKKGKKKIJIJKKKKFKKKKKKKKKIKIIKKKKJKEKKKFKKKKIKKKKIHKKFKKKKKJKKK @rCer/433/25_2070_CCS ATGGGGGGGCGTGGCCCGGCCATGGAGTCCTACGACATCATCGCAACCAGCCCGTGGTCATCGACAACGGTTCGGGGTGATTAAAGCCGGCTTTGCAGGAGACCAGATTCCCAAATACTGTTTCCCAAACTATGTCGGACGGCCCAAGCACATGCGGGTGATGGCTGGAGCCCTGGAGGGGGACCTCTTCATCGGACCAAAAGCAGAGGAGCACCGGGGGCTGCTGACCATCCGCTACCCCATGGAGCACGGCGTGGTGCGAGACTGGAATGACATGGAGCGCATCTGGCAGTACGTCTACTCGAAGGACCAGCTGCAGACCTTTTCAGAGGAGCATCCTGTGCTCCTCACGGAGGCCCCGCTCAACCCAAGTAAGAACCGGGAGAAGGCGGCAGAGGTGTTCTTTGAGACCTTCAACGTGCCGGCGCTGTTCATCTCCATGCAGGCTGTGCTCAGTCTGTACGCAACGGGACGCACGACAGGAGTGGTTCTAGACTCGGGGGACGGGGTCACTCACGCCGTGCCCATCTATGAGGGCTTTGCCATGCCTCACTCCATCATGCGGGTGGACATTGCCGGCCGCGACGTCTCCCGCTACCTCCGACTCCTGCTGCGCAAGGAAGGGGTTGACTTCCATACCTCGGCTGAGTTTGAGGTTGTCCGGACAATCAAAGAGCGAGCCTGCTACCTGTCCATCAACCCGCAGAAGGATGAGGCTCTGGAGACGGAGAAGGTGCAGTACACGTTGCCAGACGGCAGCACGCTCGATGTGGGGCCTGCCCGATTCCGGGCCCCCGAGCTGCTGTTCCAGCCGGACCTTGTAGGGGATGAGAGTGAGGGGCTCCATGAGGTGCTGGCCTTCGCCATACACAAGTCCGACATGGACCTGCGCCGGACACTGTTCGCCAACATCGTGCTCTCCGGTGGCTCGACGCTTTTCAAAGGCTTCGGAGACCGATTACTCAGTGAAGTGAAGAAGCTTGCTCCAAAGGATGTCAAAATCAAGATCTCAGCCCCGCAGGAACGGCTGTACTCCACATGGATTGGTGGCTCCATACTGGCTTCGCTGGACACTTTTAAGAAGATGTGGGTGTCCAAAAAGGAGTATGAAGAGGATGGCTCCCGTGCTATTCATCGCAAAACTTTCTAGTGCCCGAGGAGGGCGGGGCACATTGGGAGAGGGGGAGGGAGGGCAGCCAGAGCCTTTAACCCTTTTTGGTCTGGGCTCGCATACTTGGCTTAGGGTCCCCTGCATGCCCTGAACCCCTGGGTGGGCGGCACGACAGTGCCCCCCTGCAGCCTTCCCCTCTACACACACACGACACGCACATATGAGTAACATTGAGCTGCATGGACAGGAGCCTTGAGCTGGCGCGTGGGAATTGAGCGCCACGTCGGGCTGTTCTGGGTATCCCCCCGGCAGGGCCAGCTAGGCCTGTGGTTCCCTGCTCTGACTCTCAGGGCTGCCTCCCCGAGCTCCAGGGCCAGAATGCCTGGATGCCTGTGTAGCCAGTTTGGGGAGTGGGCTGGAGGGGCGTCCAGCAGCTCCCGCTGGTGTGTCATCACGTCCATTGCCACCTCCTGTTCGTGACCCGACAGGGTGGCACAGCCCTTCCACACTCTGTCCTGTCTTCCTGGGTAGATGCCCTGGTGGAGGGCTCAGTACTGAATGGTCTTCCGTCCCCAGCAAGGGGGTGCAGCCCAGGGTCAGGCCCTTCGGAGCCAGGGCAGAGGTTGCAAGGTGGCCGGAGCTGCTGCACTCTCCCCTCGGAGCACTTCATCGACTTGCGCCTCCCTCTGCCCTTGGCACCCTGGGCGGGAAAGGGTTGATGCTCATCATTTATTGAAGAGAAGCCACTTAATGAGTCACACCTAAAAGGGGGTGGGGGACATTTTCTTCTCTCACCTCACCCAAGAAAGAGGTCGTCACTTTTGCTGTGGTCAGGGCTCCACTTCCCTCTGTCAGATATGTACAATAATTTAACACAGTTGCCTGAAAAAAAAACTTTTGTAAATCATTGTAGTAATAATTATGGACAAGGCCC + 57*247<92878-<4<4.;184:=?=6;-85232:;:67999;$2<06458;<3;;=><;>7<>=6=<,91;5&-2239895$686165<18<<99:16:8;2<385.4/886:?;<=88-<6/;8'98:977;98,9()6919;6<:9<989::(25/*75;?==*;7/9<=<;?51<=8>:=>1:/8+*8=5?627'7;;;=972/=699:=?/?951'8;90><9;<42?7835,7796718367624822,135:74035:88>88.3:<:83>79==9556609/*247>3;:=71;:>8(<782<>?3>==>85/5:1$2':8751::5;9;=97<.*=6:?=;+61??6A26,/;7@;6;C=@;>@,>@?AB;9?8><;;>>;=;>=>1?<5=?ACA?94649;7955>8A@;>=>>;7@:@B>@8=4=A@8=62945<=>:@=85779>>2>677><87=7A@B>8<3BC<>A=4:?=>::>3<8,547;=5795=6>;7:?=<./;57894=2762:,'83A4<8=1;;3=<2.8@:=<<>C4>C=897>A681:3243(2(',;-99=.:<3996;=0;?4B@=.@8/?8B7C>456???;40:04.4:;2=2;4>3=@=@86C726;=9??8<8>;:A9><>>A@7//95<8==;8<;/;8;;:55>=6;::?7<:8:76482;79777;=78519;75>8/68-;=8;359,5765899/>799(6984<6(73556;;>;<=87)54<;89>7>:7A:865:1:3:6<18147;7:2=8:;;9A=>A<7>=;>B:A=??92>-;$27;9:-<5;8>B@+9;;94;A>B@4.=/=?BA<93574<@>5*;A>@?B6:<;=>?B6@B;>3;<:3>A=6?CA7:@<=6AA6@<9@<>58:<,;7>0A>;??B54=>;6;8963?;3>B@5<8-0)78:A;>A=;AB8C<<;3=;?@:=7?7><>;>=9@>;-?@96>>?CBA9.?7=<7:?0>3;AAB:;:;<5;;3:9A566:3>>=)A6997;?>7>?;?7?B/B>;:499669779-88A@===4;@@6<4,>;>-=?644:A16=?@C8@7);;BA-BA>6::<@@79B;;BB4;(@?96:=>=A=1?>445AA>@7>=@8BA>67=/?@:1+8//*86=:B>>B<=B/<799>6ACC>7?9;/:;5,:===@?A;85AB>98:@>B@>6;?<<9C>;>;@283<9=A<:?=.@;B8=:.B<3B4=<>6=C=??54=;3@@A>B8@=?2><>;@+?:>==7<<04=>>?97;==@A=AAAB=A*=3@@BBA=<@?:??9@?;;<=CB<:?=>B;@:C<@:5=:942<;@:AB;1B?5<@57;=2C@;;&9>*>==:=;>=>B>A@>=-9897>2?7;<73561==89;:>;5@?0<859,=B9>4;@9<8539=;;<=17A>@?C<#AA37+>7/<>?>>>A;B=>,42:8><1??9>8<4:8AC>AC<9:=7;C:@>,14;=7399=7879:>/:6<788;;25.9,8:7>=9>;318<<1<>;;7+80?<3@@-?;5:?20>;A;:69A1;;@5=9;0:=;@84>;/47947@?=416;<@@<>:?65B-&>A?>A;)::8?14+52=;9:56;/A@.8<78?9<=19=?;7:>5.45548=988A;@0?;9@A<;@@;@A>CA2A@7*71/88/67=<;9;;?=>98@B.>@>=9A@?>C?7?8=A;=@>><;841=<7=@:;A@=<;>?6==;C>:==;=4>=589>6998=23-99616:9:5/<988;6?<1:505<56:81-6168=66:=>;:?6?-=9 @rCer/435/25_1823_CCS ATGGGGCCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTTGGCTTGACTCAGGATTTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + ;8(98*#2854666'58=;4/&9827>2;6.484;9;9<=6:5;;:>4;>578;97391&77.88749353138894;83:5-/686082:9;881-5286-3486;9849972/7221598)6)696:9<5<:68664:6?7:4<88:7?66;1=9<<83:2)10>:>;50739>5=8==*99995=79<770:;;8<0<>>6/;986>04>=5:=1<404.'46223-55621:8;1:7*52-31313.022650-.%0.4:82595.732981487174594.7567144+4.958583343(489;57363).2(43:37-6:8977::919296;::96+.81-23'047:)8-5675-&89323216787:;35068915877.)/6689486964749694339.57844/6890773+407$+/6,4.+082471615.8;781069.30,35.579*416.(466041477270958793016/6::0:57:5,4353381,125203.64537619485.81:59981834-6/56:8;806/('043,.*658874/;;35714757,33*./.351226828.52'655+4643,7,$*5.8845674*20//464758'409-756/55152448:77/723106/69,23541041/2445/4930-241)04826:333397:/47:45(44,8859/+(%/56665)33;7761.9572368:9561214+880*.,459:527069:67,17;69854:9/50-6)20-/),/5+4215,10+51.1*,-53)6866,5:63974)0.$322192580,2/60.626/5:8:.908'3472::45/375669717*8668927/6134961786--/1465*1072*1-463878:26:23347$,202509;1+6646)1.330-/58866840867111475816:54353&($.*,%.1--5,.),+27428891:47:)5386(20..3.2(65464467.735437379456131586.7(.,0+205.9735855465368958/"1:5781:44747:897816052/6410+.'./27589557/976;9-+5(1/8438)2279::896;13669495692552572763984115/0138568644(7/3653478+695929.-185(27588329499,*:4831554334)45.5-+52-(2/3.%0-+''58.99:688580987355183015252)1(4551.6561356778,:764197/;91$,5$)8788797829987.99847$557767676624;229:9498336/$.11*69:8-12927996.2,9244556398/17/.0$4/175954416,-4420288429)/,52:95/03,306383946505*4877:97983;/%8676(0+,6:9:=::%767>0=<9=068;+61::<961?5623>;?>47:=&885+<:487:,<=<26;31>:><6576<897/1805:92:;5<.;;31&+2*/*$55:6869376;5+:=:528887=53:60786.;<5:8;5,<7(678774;376%98*(<=9;<<:7?>437:80=742==>5=1=:./02.478:8=;6?;:)89:8:>:79<556/.(83.967;259?;8=9;=?=;3<1&,2402 @rCer/436/22_582_CCS ATGGGCGAACCATTTCTAATCCTGAGGTGGTTATGAAACGACGGAGGCAACAAAAATTGGAAAAGAGAATGCAGGAATTTCGGAGCTCAGATGGGCGGCCTGATTCAGGTGGAACATTGAGAATTTATGCAGATAGTTTAAAACCAAATATTCCCTACAAGACAATCCTGCTGTCTACTACAGATCCTGCAGACTTTGCTGTGGCTGAAGCTTTAGAGAAGTATGGTCTGGAAAAAGAAAACCCTAAGGATTACTGCATCGCCCGGGTTATGCTTCCTCCTGGAGCCCAGCATTCTGATGAAAAGGGTGCTAAAGAAATCATTCTTGATGATGATGAGTGTCCTTTACAAATCTTCAGGGAATGGCCAAGTGACAAAGAAGAAAGAAGATTGGACATAGATGAGAAACCTCTAGTTGTACAATTGAATTGGAACAAAGATGACCGGGAAGGCAGATTTGTTCTTAAGAATGAGAATGACGCCATTCCTCCTAAGGCTCAAAGTAATGGACCTGAAAAGCAGGAAAAAGAAGGCGTTATCCAGAACTTCAAGAGAACTCTG + KK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK @rCer/437/24_2177_CCS ATGGGGGGGACTCGCGTCGCGACCGCGGAGACGTGAAGCTCTCGAGGCTCCTCCCGCTCCGGGTCGGCGCTCTCCCTCGCTCTCCTCGCCCTCCGCCCCGGCCCCGGCCCCGCGCCCGCCATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAGCGCAATCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGGGTCATCTCGAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCACGGTCCTGGAATTGTTGGATAAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAAATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCATGTGGTGATGATCGAAAACAAACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATGCAACCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTATGAGATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATTGCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTGCTTAGAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCAGAAGGGGCTGAAAACTAAATCCATACAGGGTGTCATCCTTCTTTCCTTCAAGAAACCTTTTTACACATCTCCATTCCTTATTCCACTTGGATTTCCTATAGCAAAGAAACCCATTCATGTGTATGGAATCAACTGTTTATAGTCTTTTCACACTGCAGCTTTGGGAAAACTTCATTCCTTGATTTGTGTTTGTCTTGGCCTTCCTGGTGTGCAGTACTGCTGTAGAAAAGTATTAATAGCTTCATTTCATATAAACATAAGTAACTCCCAAACACTTATGTATAGGACTAAAAATGTATCTGGTATTTAAGTAATCTGAACCAGTTCTGCAAGTGACTGTGTTTTGTATTACTGTGAAGATAAGAAAATGTAGTTAATTACAATTTAAACAGTGTTCCACATAACTTCTTAATTTGTACATTCCCTCCCTTACTCTTCAGGGGTTTCCTTTCAGTAAGCAACTTTTCCATGCTCTTAATGTATTCCTTTTTAGTAGGAATCTGGAAGTATTAGATTGAATGGAAAAGCACTTGCCATCTCTGGCTGGGGTCACAAATTGAAATGGCTCCTATATCACATAAGGAGGTCTTGTATATCTGTGGCAACAGGGAGTTTCCTTATTCACTCTTTATTTGCTGCTGTTTAAGTTGCCAACCTCCCTTCCCAATAAAAATTCACTTACACCTCCTGCCTTTGTAGTTCTGGTATTCACTTTACTATGTGATAGAAGTAGCATGTTGCTGCCAGAATACAAGCATTGCTTTTGGCAAATTAAAGCGCATGTCATTTCTTAATACACTAGAAAGGGGAAATAAAGTACACAAGTCCAAGTCTAAACCTTTAGTACTTTTCCATGCAGATTTGTGCACATGTGAGAGGGTGTCCAGTTTGTCTAGTGATTGTTATTTAGAGAGTTGGACCACTATTGTGTGTTGCTAATCATTGACTGTAGTCCCAAAAAAGCCTTGTGAAAATGTTATGCCCTATGTAACAGCAGAGTAACAGAAAATAAAATTACATTTTATAAACCATTTACTATGGCTTTGTAACAATTGCATACCCATATTTTAAGGGACAGGTGAATTTACTACTTTCTAAAGTTTATTGATACTTCCCTTTTATGTAAAATGTAGTAGTGATACCTATATTTCTGCATTGTGCATTGTGACACACTTGTCTAGGGATGCCTGGAAATGTATAAAATTGGACTGCATTTCTTAGAGTGTTTTACTATAGATCAGTCTCATGGGCCATCTCTTCCTCAGATGTAAATGATATCTGGTTAAGTGTTATATGGAATAAAGTGGACATTT + FK3KKKKKKKKHIFJKIKIJJJCJ?JKGJ?FDKKKGKHKJKIHKKKKKKKKKFKJJKJKHJH=KKKIIHEKJKJKKKJKJH@KKKJKKJIKJJKJGHKKJKIHHKKHKKKHJKKJJJKKKKEKKKF1JJKKKKKKIIKJKGKEKKBKKHIKKKKK@KJJKKGAJKJKJKKJ5JKEJJKFKKKIHA>JKKIJHJDKJKK:KI=HKKJKJGJFKFKKK8KGF5KE:KKJJKJKAKKKIKJKKKKFKKKKJKHKKKJGKKFKEJKGGKK6KJKKIJKKJ-JKD=KKIK=KKJKKKFKCJ8KK;KKKFKKKKJKJJKJKFKFH6GDK(GKKKEKKKIK;KKIKKKJKKGKJKKKKIKKIKKJK7KKJJHJKFKIJKKJJ7GF?CEJJ:KJCKK4JJFKFKJKIIIBKKKKKKKKK:KCHH?HGJKKKKKCKKKJJIGKHFEKB7CKIJJBGKKKKKKKJJIIEKKIJJJIKJ>FEKJCFFJKEH>KG=HHHA@EE>HE?JKKCKDBJKJEHKJDI>KKKKAKKKGKJJF-HJHEJ5CE?KH0GJKKDHIHKJ3JKIFECJBKFJKIDHDAJIEGC=JIJKK2KJIGDAGCIDK8KKFJEDI9JHCB@IDBI8HKGEKI>8JKDJI4GJKEJHKICIJ@FEJKKHKFIHHIH4JKJKIKJJIIJGEIIHGJKIIHKKGKIJJ@HHKKKJIIKJAJI@KCDH4KKBIKAK=HGJGIJAJABFAGIDHHIJKJCHKJJICKK @rCer/438/0_1336_CCS TGTTTTTACTGGTGGTTTTGTGGCTGTCATTCTAATGCGTGTGCTTCGGAATGACCTGGCTTCGGTACAACTTAGATGAGGAGACCACCTCTGCAGGTTCTGGTGATGACTTTGACCAAAGGTGACAATGGCTGGAAAATTATCCATACAGATGTCTTCCGCTTCCCCCCATACCGTGGTCTGCTCTGTGTGCTTGGCGTGGCGCCCAGTTCCTGGCCCTTGGCACTGGCATTATTGTCATGGCACTGCTGGGCATGTTCAATGTGACCGTCATGGGGCCATTAACTCGGCAGCCATCTTGTTGTATGCCCTGACCTGCTGCATCTCTGGCTACGTGTCCAGCCACTTCTACCGGCAGATTGGAGGCGAGCGTTGGGTGTGGAACATCATTCTCACCACCAGTCTCTTCTCTGTGCCTTTCTTCCTGACGTGGAGTGTGGTGAACTCAGTGCACTGGGCCAATGGTTCGACACAGGCTCTGCCAGCCACAACCATCCTGCTGCTTCTGACGGTTTGGCTGCTGGTGGGCTTTCCCCTCACTGTCATTGGAGGCATCTTCGGGAAGAACAACGCCAGCCCCTTTGATGCACCCTGTCGCACCAAGAACATCGCCCGGGAGATTCCACCCCAGCCCTGGTACAAGTCTACTGTCATCCACATGACTGTTGGAGGCTTCCTGCCTTTCAGTGCCATCTCTGTAGAGCTGTACTACATCTTTGCCACAGTATGGGGTCGGGAGCAGTACACTTTGTACGGCATCCTCTTCTTTGTCTTCGCCATCCTGCTGAGTGTGGGGGCTTGCATCTCCATTGCACTCACCTACTTCCAGTTGTCTGGGGAGGATTACCGCTGGTGGTGGCGATCTGTGCTGAGTGTTGGCTCCACTGGCCTCTTCATCTTTCTCTACTCAGTTTTCTATTATGCCGGCGCTCCAACATGTCTGGGGCAGTACAGACAGTAGAGTTCTTTGGCTACTCCTACTCACTGGTTATGTCTTCTTCCTCATGCTGGGCACCATCTCCTTTTTTTCTTCCCTAAAGTTCATTCCGGTATATCTATGTTAACCTCAAGATGGACTGAGTTCTGTGTGGCAGAAGTATTGCTGTTCTCTCCCTTTCTTCATGCCTCCTTGAGCTCTCCTACCAGCTTCTCTTCTGATTGACTGAATTTGTGTGATGCATTGTTGCCTTCCCTTTGCCTTTGGGCCTTCCTTCCCAGAGAGGGCCTGGAAATTATAAATCTCTATTACATAAGGAGTATATATTTTGAAATTTTTAAGTTGCCTTTAGTTTTGGTCCTGATTTTTCTTTTTACAATTATCAAAATAAAATTTGTT + S&$,,,+*+((-)$,$),)-/%,)&&150.1+.(/)''()../(35/3655.2,.51560%(*',3.3065)13+0.#'*//..00.53-4145105/61-*2*440'22*552400$,$*,+*,-,52666626*)*1.05/434.1--+0'0223621/*-3/641664-/110.02/,52144,#$/$-)24,3211#1/2.342%1656516464,1120-.2-63-'2%$/0525+-1-03435/+01102.,4)000,+(%.1///.2&34236//422(&+/6044/3005///*..).45,424365611,140522)$/*42./504.1*5440614/,504663600//+5+43.5455126142/265110450,14/'.1,/)/5231-/-((-(53448:22752535-44;::428505855871755497196:668-444:6755100006::8.2898;:583877223754%5+13825748388-6/+6336:*8639324:58563:82*.3'.8657::908928:684/;8.67:96.51,879836;:85744,251.4580/0684567*1041..*-:4/.2/+.,7894974-317558.5,9347762)+()02.754:3357.203.554+7/1558)4347%1%-343.,38*93&26::443/.(452'3626:52./,10,0594:45321-,-2*.3/..32$/+)+'67:7579193+-858;304624748:8;99856934/84205.**2-58235.66586+-+0*61/-,37;7447(%00.01655684815388*4;9;44:2*7'/888-24/08/8:824488837358799:1::;856:35:/955364:5754%76311.4:0.244:67588-7.23&84954+0053:4*465-2-00:5,611014249:::629/21141.7.-5.,%-%%---//,-.).(150+,/+3422-./0+-./16-0%-150112&324420.'4(231/14/0501'-)2,34544-+0414*))0*/40(3/-41102053-1131..2-%5005.3.0456442/040+%.(-3/534,#2*-.)2)+1-62503)2/&*3652.51./554*4,*)+&(+/+-.*)&+**+1*0)&&+.(,*&+##*%*%*'&0-0,+).0&-.+**-)+.-$00/-101-,1,21,0'.0.21--.0-',1(-,.+*1,0&10)+(*+&&($$+-1*)%(%-..+1.&//-1-,/11+222.2.0,11.'0-+-'%%+,-..-2&.)/0),,,0/1-2122,(. @rCer/439/0_440_CCS GATTGACTCCAAGTGTCTGCACTTCACTCCAAGGACTGGAGCAAGAGGGAAGTGGTGACCAGCACTGCCACTGCAGTGCTAAGACAGCAGACTGGGCTGATAGCCCACCCGCCTCACTGCAGCTCCACAAAGCACTCTAAGGAGATGGGCTGAAAAGCTCGAAAAGGAGGGACAGGCCTGGCAGGCCATTGTGCCGGCACAAGGCGAGCTCAGGCTCAGGCTAACTCCAAGGTCAGCTGGCACAGGCCAGGCCTGCTCTGAACAGGATCAGAGGAGCCAGGCAGCTGTGTACAGTGAGATGGGGTGGGGAGCTCTGTACAGAGGCTGGTGGTTGTAAAAATTTCTTTTGTAAAGTAGAAGTTGGGGTGGGGTGGGTGCTGGCTGCAAAAATTCTGGCTTCTCTTATCCCATTGCCACGGCAATAAATTGTTTCTATATGC + SKFKKFKK/KHKKKKGKJK'KKKK/KKDKJKKJ&KKKK?K-KJGKKKJ0KKKKK)KKKKKKHJIKKK7KGKKKJKJ%KHKCKKJKKKKKK/KKK6KKC1KKKKIKKKKK?K:KJJ>KKKKK@KKGHKFK@KKK6KKJKK?KKKKKKKK0KKKBKJ2KKKKI2K*KK)KKK6K5KK>K(KK$K7KKK+BK9KKHKBKKKK0K1KKKKJKKKEK1KKK4KIKK=K1KKCKKKKKGH4K:KKKKKKK'KKJEKK8KKKFKKKKKJKKKFKKKKKH#KKK1,KKKKKKKKKDKKKKKK?KKKDKK'KKKKKAKKKKKKKKAKKKKKKKKKKKKKKKIK7KKKE&KKKE6KKEIKK:KJKKK+KKKKKKKKHKDKKKKKJKKJBKKKKKK2KKK8KKFKKAKKFKGGKJEKDJCHKJJJIJJHKKDKK?KJK@>AII@GF>CKKI?IHIIEHKIDJKKGG/BJGIIKEJKK>E=@FGEIIKGJHF?DEKKH3JIEGKJKIJHJ:DHKIKIJIJKKKJKJKKJEK>IHEJIGIEJDJFEIIKJIJBIKIKKFKFJKJGKKJKIGEHEG@KHFKGKKAIDCE=BIKI7HKKKKIDGDCDJKK4EEJCGJHIK5HKJJGKCKKKJFGDJ@EJD8;<@JIKCJFJKKA0GCHFEHGJKAG>IIJKKJJ;JKJK7JKEKJGFKIBGEIHF?EF6EB3CHGIHJDKKBI=EHG&GB@AFBK=KJGJ;DJDIJBKKJGG@JBKJI>KK@GEGJAA9?JIBGJ@FEKJ=KCJKKH?FEDKJIKKK8JKIGHJKIKKGKIKCADGJJKK9FJ2I8;JFJKKKKKBKKJIKIKHGIK2KKIK7JKCKGIDKKH21;HKKJKHKGCBIAEGKKKFKKGG2>HIKJC1=CJKG>>KK-FKAJKIJJKI@IEKD@KDGIKK6K?KCKKJGIIID.KIKHB=DEKG>C?B7JHH5JKEKKGJJAJKJ>JKJ7HEH:FKK@KJ@EKJKKKKFHK5=KGKJ=KJHKKE@JKKKHIDGIH-I=@:EKK:KKGDKJIJKCJKKKKCJJKKJK;GHJBJAKJIJ:IJIFIJEKCJJADDG.HI;JKI@K>JCK6JI?>:KK@KKKKJJ0JKGIJHIAI8HDGKF@KFBF(IKJ@KKF7BKIHH:DBKKI@FFHK:KGKFIIJH6HAJJKJKK::>JJJKKGKBJKK@GEAGKKK=KKKGKKKHKKKK:IJJGK/JJKKKJCBIKK=FIJIEDHHI/EDEHJK0JKCIFKADAG>KAK9HFHAEJ4H3KJGH.KDKDKBJHAIK?IJGEKEJJ?E7JFGDHHKK=JHBB-EK7EEIDJCHDH5=A@JK>KIFIH6@AH2AKDH:>EBF8B@K6JGHIIIIKJ2@F+CI @rCer/443/2176_57_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCAGAAGTCACACGGCCGGACTCATATGAAAACCCGGTAGTCCACTTCTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTGCTGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCATCACAGAGAGCGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCTGCATGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCTCCTGAGAAGATAACCGGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAACAGCACGTGCTGTGACGATGGCTGAACGGAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + 5650&4467154:55),32-34'5842/57575+35'.2361947352,)5757>8626B?C@8B8:@==B>*:>>300?81G=GJ4BDH=B@IBDF+>B/E6JHDDIH@AFFG7?IJ:CD@AD@F&:$CCCJ3EI5I.CDE%KGG4BCG=DB=:?EDFF7*?GH+J;EHDIG;DGBF:,CF@E7D==3B29?0>>4A=?A,B?@AAB4GBFE?47.CA8@F@JK;H7;;GCE1FI:HH9>FJJG&:EIFJKEKJ1IICFF@IBIDJFGH-DKKE=AE$>GK-@DDFDI'H>C;C?HIHH2D:>CGHI==JKJ1EA=9DIGJFKJJD1:C%DJ+&"%F=K;K>C2IFEDB>F*FDCB9E,FB-<6GI9E2C?JI)K8JKH,HG-?;8F'IKK9JHDA,DKIHKDHH;E3GDHHJJHFHIIG3HAEGG-ED)CFF;GDAJB?DIC@IDGBHKIF;IJGA:FHHHAFEAC?A2=7<@.CG?%G,FH?BJ+HFGBI9HAD>BI8CG:HED=ADE?8=AFHG4G:CBKH0GG=IDDIG4HGGHKJCEJ=IBGJAEEK@E:@D@A=H@HAI2DDED(;FA>:3A:8*C5&>DAD;C7*DF6GF8@DE.F6D.JJHB>=DCB38BEK;JJBGID4H?;BCB8DF;4HK?III4BJIHG=@FKK(E8EF;DGI?IE)?CCEEEGGKBJ&B@GFDG0GFCCFDDBC=JF5FHC6EGEI;?FCB<>C?IFGEEED)FCE<<@?B)H-$=GCGGJEHFFHG0FIFJHFD0D?)@F;IJ7AJAEI/G@HGCIDH8KDJDDAJB>JFI1KKKDC;IIIE@BGCDEBD=BKDI6IDAK2IH=?EEEAKKAIE)@GAG?)CD=EK+8CAJJ>(C5F:>GJFK@DJ2>09JHJH8+/G,KJJIJGGK/BFECG-G@GAE>,I7GK7HHFAD;JFIHBAF5=D?GAJHG>=HA-D5=5@CA<4@B?CCDEDH2JH1EA@EIGF3AEBC?=;AA6G?7D3>ECJDB&%);GIBCE5BA3GG?=G$>@HB:GJIGCBHJ8FGEJBF2AH89BH??.GGEHEG,8G*(/CF3JI;H>EEDCDF8;=4AFHBD=F(FBGFGIEF*'HFDDD'=DG6EHC9@DDA?*CFCE@5;.>=C@<4D-EF?7F7<)HI@HHG+@CC;DF;BCBE?&FIF1@CEICDBG9C<7#EIBE0F:8EE>9(5?4B>G2HCIIF>E?HFDB=C'F?BGIIG>G>JCG.EI5E@6-6=CB8;>CH:F?-=CF1GI?9GFF1?;E35;=;;;@IBDCAGGFIIEBFEE>?BGE@GDFAA;7:9DFCA)?EJJ/H::6;>>961874%8*2.7/'18:764'48870645=38<20?64<1=:571",749=6/3782:1:(162'7);)056886(:.381%/;'8:49>;=9::6054791)3(>398/7'':'<9-31)&.&9<$010,)//;37967:87%6894:6791&/1257<43524422&/$5;82&1(-'70776*<73*40+)131,6,6200356)')7474/,%780'66:104)3(6999+992/%-<=97594$2.))857170;:,>8>5$3/95/0%<<98&6(93568,8855%&39<=.46;-0<;%%07;;*#454*1-088(&66/903*(616+344)32,.(<,4+245'272*"*67*0)6;05<24740'.514210$0848)15':214961*6788;14&*.24%38836*8<<76%5;848:9.2-:7;(<7787&939058320'$&0)=25<91875**(07:99>2=9953*75#+01*323018=.<<7=:;:7*::5/(&5%0884)'7>46*162%(-9)<7:-87<:(702*/'+,.5415-01.2538-7+371,;18?3*6/*+5+$,0699(<6*72:9663442'18.1/'036363/3/1+/*$+670;1080;78'+--62246.177-&445,*4.386,2-/,1,')1/53692+,32(/3-212%5'+507$,3)24,4$343160$2-4-+7-:92576$'043$)8(7+64.2168/6;750+4291&28)*)60)./.-.25*/'%*%.11215.12*50&/./&*.)%%/,%*0*+./)++.&+(''&.*/-.&.,*,+()//(+-&0.- @rCer/446/0_1695_CCS TCTGTCATGCTGGTGTGGTGCGGCGGTGGAGCCTGCGGGCCCGTAGCTGTACTCTGCGAGGTGCAAGAAAGCCTTTGCGGTGAAGGTGTATGAAGGTCATCATGACAAATGTTTTCCAAAAAACTTGTAGAAGGCTGTGAAAAAAACTACTAGGATCACACGTCATGTATTGAGCATATAGGTTGCTGTAGATGAATGTTCTTTGCTGTCATGTTTAAAAATACTTCTGCTTCATTGCCTCAAGTGTGGCATGCAACATTTTTGGAAGGAAAATTGAAGACTTGTTCAAGAAAACACGAACAGAAGCAAATGATGAAAATGAGCATTTTATGTGATGTTGATAACATCACAATAAATTATGGAGAAAAATACATATTTGGCTAACTGTTTTAATTGCTGAACAATAAAGTGTTTTCTTTTAAATCAATTCTAAATAGCTCCATTCTCATAGTCACTAGTCAGACCTGTTTTGAACATATTCGAAAGATTATATAATCTTGTGAATAATTAGATTATTTATGGGTGGTGATTCTCATTGAGGCCAACAGCTGGGAGACATGTACCTCTAGGTTCCCTGTCTGGCTCCCCCTTCAGAGTTTGCTGTTGTACCAGATGGTTGGAATCTTAAAGCTCTTTAATGCCAAATAGCAATCAAAATTCCCCCTTACAGATAAAGGTTTCACCTTTTTTATTCAGTTTGCTTTCATCTTTGTGAACAAAAAAGTCATCCTAATACTAGTACATGTAATAACTAAGCAATATGCTATGTTAAGAGAAATGACTGGGCAGGCCAATCTGTCTAGGACTAAATTGGCAAGAATTCTAAAGCTGAATTTATATCTGGGTGAAGGCTTAGAGCTAAATCTTTTCTCCTGTTGAGTACTAGCTTATAAATTCCTTTCACCAAGGTTATAGTTTTTATATGATAAATGGTATAAAACCTGTATAGCAACATCTTAGTCACTTCCCTCAGTATAGACTTGGGGGGTACAAGTGCAGTTCTGTTGCATAGGTATATGAAGTTAGTTTGGAGTCTGAGCTTTTTGTGCAGCCATTACCTGAATGGTGTACATTTCACCCATTAATTTTTCATCCCGCACCCTACCCCCTTCTAATTCTCCAATGACCTTTAAAATACCATTGGCAATCATATTTAATATTAATGAATTACCTCCCATAATTGTTTCTGAATGTACACTTCTACTCTTTAGGCACTGAAATAAAAGACTAGTAAATGCAGCCTTTGTAATGAGAAACTTAAACATTTAAATTTTTTGTGGTGAAGTAACTATCTTTGAGACAGGTTGGGTTTTTTGAGCTGGAGAGATTAAGGTGGCAGTGAGTTATGACTGCATCAGTACGCTACAGTTTGGGTGACAGCTACATATAAATATGTATATATAAATATAGGTAAGTAAATAAAAGCCATCTTTGTGCATGCATGTGGCTCACTCCTGTAATCCCAACACTTTGGGAAGCTGAGGTACTGAGATGGGAGGATAACTTGAGACCAGCCTGAGAAACATGGCGAAATCCCGTCTCTACAAAAAAACACAAAAGTTAGCCCAGGGTGGTAGCATGTCCCTGTAGTCCCGGCTACTCGGAGGGCTGAGGTGGGAGAATTGCTTGCAAGGTCAAGGCTGCAGGGAGCTGAGATGGCGCCACTGCCTCCAAACTGGGTGAGAGCCCCTGTCT + S,&((%+$*-(%&'*'')%#.&,)'31030,,4/+7564)*63,2641+&5-6441,9736341+3+*369335;;52.67:8525455765(7266:4,579<6)33976$;512<&646:7637+(7/24-247;58%7::988<=;66;7:4766,3989=047303<89.0/16/078+247.9//065;++1'(5-)8600#1-+4/-32/&'+03.57038772-/721253::8;5842209)&/95%),,$,.&$(512.6,6:9976-09+15A;5;:6.1%35776AA6@9=;;>96)4;:3>?@+:>>:;8=<<-5168=849>4-1>:8.9?7214>44*586359??;A>A95B=B:A>A93A>@1?9@8:9=9?<8316>A@2??>16=EAF?1DCB@=5EC@=AFF=84@@-?;?=8>36/;99;3;<>=4&@B<3<1=1==>4:?BAA>C;A=@;=?CCDC@E-CGFCEEB:=A9>49<=@A9?B;:A@/2*,547A<:9<==><5A@B4>=4AC3A@?8@597=<5>;@>=%3189E4C<>C>9;;>:@AB><@@;E,=C:;9;::798<87A?:B:EC2@-;>-53195?='75970?C6+47/-81?99=;/=:89@>@6=2???F:C38A>=<::<958?A=@=73BA92;=>>=;+3,*.)-A:@=?CA>@=D<;BC>C*<=?@?A/A>@8@?:<%67-38>;<46@?=A977?A=?;A:+9:86;/.*/1:**4%0-.-36;?;<=:3>;9:*8:<<88-5:5-465628/;>9=865>7;:?A;7::;>?>11893+8==;954:-492.%202.-7>@96>9?,37<4><;11:0<5.9;:;<695.>3=:%&<@95A7;?8=:8?A4>>?884:<;@9,=9791,.3<6=B9>7><23.8@?>7;=9<;A@9??B?C?;+@7>?8;:8754==/=78<=960222=4816+4=7@?>-;@>?7<=;=A??4C?,2><;7>;@1/'6,6):>2=5?39;;>70068<8.5487;.<@;@>59?/=<9=$36.+4<;;=84<43723407<@>A=997:=;41/5719641:>3@?:7?8;;4;??6=3AB3>=<=?-;B<>9@?>2@:;A>=:;?A?72<5%6=5:=;>5A71<92<8;;@948<6AB<.1A22?88@?151<55::==9?7;9:>?5;>=@;%5531?9=;?=:6>9;.6732;=:3:5/32%@=8>65>=*?:;AB@??8?>A=+6AAA?*3695;:=A3>5<@B:C?<1<8>>@??8<=7>:;4>>;?B>?9B;<8;?:6>A)@?==7A?CBA85? @rCer/449/1957_56_CCS ATGGGGTTTCAGGTGTAGAGAGGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCCCCTGGACTGAAGAGAGGGAGAATAGAAGCCAAGACTAAGATTCTCAAAATGGTTTATTACCCAGAACGCTTGTCTGGGTCAGTCAAGAACCATTTCCAAACAAGAACATGGAGGGAAGGCTTCCTAAGGGAAGACTTCCTGTCCAAAGGAAGTGAACCGCAAGAAGAACGATGAGACAAACGCTGCCTCCTGACTCCACTGGGCAGCAGTGAACTCCGCTCCCCAAGAATCAGTTACCTCCACTTTTTTTAATCGTAACACCTCATTTGTATTACATATGGTGTATGGGTATTGATGAGGTCATGGTATCATATATGGATTTTTTCTGTGTAAATCATCAGTATAAGAAGAAACTATGGGACTCTGAGCCTTGCTTAGAGAATTTACAGTGGACAAATAGGTATCATCAAACCAGTTTTTAATCATTCTGACTCAAGTGAAAACGCTCAGAATTTCACACTGTGAATCCACGTTTACAACCCTTACAGGTGGGCCTTCAGGCCTGGTTCGCTACAACATGTCTTCCACAACTCAAACTCCCACCGCGCTCACACAACCGGTCCACTCCTGCCTTTTCACTCACACAGCTCCCGACTGCTTCTTGCAGAGGCTGAGAGTCCCCCTTTTTTTTTTCATTTAGATGTAACAAACCTAGTAGTTTATGTTCATCAATTGTCTGTATATCTCTATATTTTATCCATGTACTCTTTTGATGTATAGAAGTAGTTTGAACTCATTGGTTCCTTGTGGTAAGTGACCGAGATGCTGCCACAGGACCTGAGACACTGATGAATGGTGCTATTTTGGACTTTCAACATGCTCCTTGGCGAGGTAGCTCTGATGGAGTTATTTTTTATTTCCATGTTCTAAGAAGGTGTTGGTACTCTGTTTCCCTGAATGTTGTTCTCTAGACTGGATTGACTTGTATTCCTTGTGTCTTCAGTGTGGCTTTCTTCCTCAGTGTTGTAGGTTGAGCGAATGCTACCAGAGTGTGAGAGACAACTGTCTCGTTGACTGGCACTCACGGACATGCAGTCACGGTAGCGGAGCAATCACAAAACTGTAATTTACTTACCAATCTCTTCCTTTCCGTAGCCTCGCCTGCCTGACTTAGAGAAAGAAAAGCAATAATTTACAGGCATTTTGAGGTGTCTCTTTGGGTTCTTTCTGTTTGAAAGGATACTTGTGGAAAAAAAGAGCAAACCTTTTTAAATAAATTCCCCTGAAAAAAAACCCCAAACACTGGCATCTGAGTAGGAATATGAAAATGACACCTTTCCAAATATTAAATTGGAAAGCAATGTCTTTACAAATCATAATGCTTTTTAAAAGGCAGAGCACTCTTTTTTTGGCAATTTTGATAAGCAAGGTGTAGATTTACATTTTTGTCCTTGCTCCCAACGAAATGGATAAACAAAATAAAATACCATCTACTCATGGAATGTTGTTGTGTTAGCCAGTCTGAAAGCCCACCTTAATTTTTATATAACTGTCTTTTAGCTCTTCTTTTGACAGGGCAGGCCTTGTTCTGAACTGTTTCGCTTCTGACTGTTAAACACCGATGACGCATGCACTGCACTTCTTCGTTTCTTCTTGCTCCCCCATTGGCCTGAGTTTCTTGTGCATTCCTCCTCTCCTCCTTCGTTAGAATAGGTATATCAGCTGTGTAATAGAGCAAGAAAACAGTATTCTGCATCTGTGGCATTTATGTAGAGTTGCAGTTGTGTACTGCTGAAAATGCAGGCTTTGTAACAATGTGATCTTTACTGATGCACTCATGACAAGTACCAATGTATTTTAGCTATTTTAGTAGTATTTGTTCAATAAATATGCAAGCTG + IEI-$%#,)GJKC=GC53C=BI.D9C/A77IK?DIKK>E?JKKK'HKKK+JF68EK9KG5&1H$?K09E2KKI>BJGJH%CHKFFJHJ%DJ$)*;IIHK>BFK0K6JKKK-KKKKKE4KFDKK@HKK=KKHK%IKCEKKGJKKKKKK7KKAKJCKK2K>KI3KK/FKIKDJKJKKKFKCK@DK0JAJJDKK)K;@J0K*KCFHHJ*BJCK8G;GJJK3K6KGJ;FC5KK3KKKKG@JDKK9JKK@IKIKJK'KK@KI:IK*HKEK?K<;EKI&KKKJKIFHJJKKK1K8GKKKKJ;KBJGCK,GGKFKKKK=IJKKKK.KHCEKKKK-KK06HE9HKKKKKF3K4JKKKK,GEK:KKDK9I8JK7KKK=K?K=KHK7K3JKCKIIJJKJKKHK)KKIKKIK@HGK>KKKKK22=KK9FKKKKKJKG<1BGKAKAK@FKEK;9K-KKK2KKK6KKKK7KFJKIKKIIK2KKKJKKGKKKKKGKJKKKKKKKKK1K;KKKJKIKKBGKKKJ?IIIKK+CKK>GKBJKJKKKKK7KKKKKJK?JKFJK=HKK3GJ'*JKKKHK*KGF&KDKKKCKKKIKKKKJKKHHHKJCKK0JJ2K@JKAKKKKJKJCHKKKKK>;KKKKKKKKKK7K>KJKK8KK=KJEDJKK3IK*KKKCKHK?JK*BEKKJKKKJKCKK;KKJKIKJKK6K1K0H<4HK6FKKKKJHKKKKIK*@CBJKJK'CJE?GKEIK&41KF)?IK2KK/KGKJKK4HIKJKKKKKK=KJJK5KJKJKFKKKKKKI8HKK6K=KIJDJKJJIGKKKKKK.KAKK0KKK;J@JKFKKKBKGC;@KIKKK>K@JKKKK2KKKHKKKK@EK.KEKKKK2JKHHFKHIJKKK/HEKK>KKK;IKIKKDIHKKK@KIJJK=KFBKKIKCKKKGFKHKIKKKCKKK,KKKKKJFKKKK9K;KKKJKIKKKKKK+IKKKKK>EKKK;KKIKKKCIKKCK7K@KKHKKJK=KKKKK:KKHKEKJKKKJHK@KK;JJKIJKKKKJHKKJKKKIFHJH8K:KKJKKKK#EKEJK3KJAKKKK(KKKKGKJKKKIKKCKKIKJDJIKAKIH):>KGKKGKIKGKKKKDKGK&HFEEKKJIHKKK8K@H;8D*HHDJGHFIGEK:IDED;KKKJKJEJKIKKE>HJKGGHFKCBEHK&AAGHKKKKK1JKKKDKKK7EKIDJ@KKJ'GK5GD>9:813<9;.76,74;65839<9545$8==1*87;:1/?9221>5>==56?7:9<<)8:3501<968*=6=;>187;>8:913/25:88?=7398=7?5<:;9<6/-$:8(;<;;60<87=5/5::=>>98:77:5778.,)4;907..++*99;=6=97=4+,87<88>>7=48$0;';>417:7=::<=527==16794#3:?>:=99;2:<2<2:882/<8<:774<;9'986:67>91;.;5>17859>98<8:86.008<86;4:<9:><91+/5;<=):>56957%7:19>9+35;;::=9<>?=4:=:;=0767<%279=>;=<>+?:6=7<>7912;<.;87>2166+909057<25=2:<:86467;783=4+67>2:>:608=9/;7;?97<7=;2??79::5<0349%84:*>>?=7<8/?<;>;9<:83+?:>>8:&;=875:>697:26;:;=*#5)$)968<2<;?3834$4>;:7<645&48*8:7%$*4195999.887:>::307=::>0;:.4.;;36,959<:?5889/:64%>077=3>;=;><9:;'6=.3;33/::28:7=>=8*9=961431=9;45>6:394<;9=9<:>5=:>;<=8::6378:0757><98=<:;78,.)+46;;?8997?<369?8>1<1>;<=29:06794,9;$48>?:<;;2;?:;9348-:==36=:4<;8<=58976;7682=4<>850=1>89/799;9;78<38*298<==;71/<8(3991.6<:97**39=<:87194:+<;;??89=79:42.10&7708;8427.:44%,8840,268-7890633'$'/&/775578.898:8536947,852(41-4549767698457770*317:559:888::78,345737+677595914:,48:9;7985:09-0)895'91,2/344+-003.51&/.7:;97375:744:6.:36952/26*5867678999/539;::9:0,95:5,+3742.549.73+5+86'20455659769-512466'73746551106:8:;934332'2775554.51'3365897/0/4.6.5/)5003751027:;;4-9567574-5445:76903595-10011-/14'9.403844'125/8966.7::8.047:70571538(9544738628:875+2043)4.004095:97:7:08&08/:::726776744/&2029939267-36+'8:57:75.58625552828555432435688:7077613564.45+-&39:*4286:3.:543127-8466277+3973%:179+7688719:-68245*6343108:07616*-017+4:7.441344141.03276*135/12440/687478)784381795:3::55.6:6:87:42-965353+:82/1667:85945+3::69874/7:3:8897::53996/:244--6476;;38861792-1+3:948;7;984795948958679;959364-4.31*6:6842:949837310158---%2%7376746037.8359(56::6738:6786/3886,-.:8:995:::4956.832*5.8:::9*0,.17:366*98:9;4148/404/4255.6:9:7:819698:547-9881.-0..444+/34.21+9471787645+3613681649;92353:::9;6:5873976;61(:352&20779:.8972.9/96833:956:9:/7:743667014460:254651-735/-%230241796+39344860/5)7+48;577-57:2;::47:65887.9::879918:.7258:68695982536%,-47863$244,)0(,564-6--947:;;:85.--66(2-:.28654965,7776'42,6878+9:7,:69.091::464::8:4$0299959942196'4690::6933//17:623)9678778/::5:986:6757.294438539;65955189.7628::13:::894,&94::55,.25.25990683787)7:66/;6:: @rCer/451/25_2106_CCS ATGGGACTTCGCCCAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCCAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGCGCCATCGGCAACATAGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGGACAAAAGATCCTTCATCACCGAAGTGACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAAGCAGTCAGCACTGAGGTGCGTTTAATGATCACTGATGCTGCCGACACAAACTGCTCGTGCTGACTGGGCAGTGCTTTGAAAACACCGGAGAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGATTTTCACCGACCAAGAGATCGGGGAGTTACTAAGCACCACCCATCCTGCTAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGGACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGATTTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAGGACTTTCTGAGTTTACTGAGTATCTCTCAGAATCAGTTGAAGTCCCATCTCCCTTTGACATCCTGGAACCTCCACATCGGGTGGATTTCTGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGGAGGGGAGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCAATGGCGGATCGGAGAGAAAATCCTGCTTCTGGAAGCTCATCCGACACTTAGACCGAGTGGACTCCATCCTACTTACCCACATTGGGGATGACAATTTGCCTGGAATAAACAGCATGCTACAGCGGAAAATTGCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACTGGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTTCTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGAAGAGAAGCATAGAAGAAGCATGCTTCACTCTCCAGTACCTAAACAAATTGTCCATGAGACCAGAACCTCTGTTTAGAAGTGTAGGCAATACTATTGATCCTGTCATTCTCTTCCAAAAAATGGGAGTGGGTAAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGCAGTATTTTATGCAGCAGTGGACTGGCACCAACAAAGACAAGGCTGAACTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAAAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAATACAACATCCTGGAAGGGTTGGAAAAACTCAAACATCTAGACTTTCTGAAGCAGCCGCTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCACAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCGCAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAACAGTGAAAAAAGACAAGCCAGTAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAGGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCCGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGCAAAGCCTGAAGACAAGAAAGAGGAGAAGGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAAGAAG + KJBKKGIFFJJ6KKGBKJJJKKKKFIK4KGJJKFBJKKKGJKJJFKI?KICK?@JKHKK6KJK7KKKKIKJKKIKKKKJFDJHFKHKKKGGKKIJ7KKJFKKI7KKKKKIJCKKKFJDJKGKKKKJKIKJJKHFKGFK=KKKIKIKKKKKBHKKJKJKKKKHI1CKFKKGKJIKFKJKKKKKKKJKKJCKJKHIKKFKKKKHKKJKKE@IKKKFKK#HJJKJJDHKGKKJFKKKJKHEKJKKKKKFJIKJ9JJC3HFHHHFKIKKKKJKKFKKKKCKGKJJKKKKJH?GG;DGIBIKKKKKKKK>KKKHKIIKCKKKHKKJKKKKKKKKKKKJKK?KGKKKFKIJKHKKJKJDGKKKKEFKKJKKJHGKKIFEKKIJBJJKKKGJKKJKHK>K7KJKKKK2KKJIJFKKFJKKIAKKFKIIIJGIKKHKHDJKKFKKJJKKKKKJKKKKCKIJDKKHKKEKJKIKKKKKGKKIKKKKKKKKJJKKJKK&KKFKKKKKGK@KKKK7KKKKJKKKKKCKKCKKIKKKAKK5KKKKKKBKJD@KK<>KKKKKKKKKHKKKKKKKKKKKKJKKKKKKKKKKKKHKDHGIKKKKKKKAKKJKKKKKKKKKKKKKK?KKKKIJKKK?KKKKKJKKKKKKKKKFKKKKGKKGHKKKKKKJKKKKKKJK:KIKKKKKKKIKKJKKKKKKKKKKKKKKJKKKKKHKKKK?KHKKFKKJKKKKKKKKKKKKKJKJKKKKKK3KKKIKKKKKKHKAJJKKKIKKK=KKKKKK>8E@>JADIGAKFJAFDJIJK?IJIJEBCAFIJ.JJIIJ7HCFHHBEJKJCEIJ=HKJGE.3A;;62=KDE>K>KGEECGDEBDD8A?@=HDH;HGJEGJIFGJ@DBH?FFEIG>HHD4?>G>G9EE4<@5JBBH4=HKD30FIHH6KJEHDHHDFGII?E<=D8.BCEGDGEC@GDEGCFEFE*C@>9ADH8B>4=5HJCGIJCHJHJKBII7GJFBEGHHJFECC@7K=CBE@A@FKCIH4@K@IG==6E>EHIAJDFHK=A@CIBC=>8CGEEGFBFIDEJ5KD=EGBDDA>HGC.HEH;@;GB=D?@H>GFD=CDGF@HIJK9:FCBJKEIHGDFA?DIF9FKCHEJDG>AHIG@H?KGJBJKFKFB5(HGA@D.=IJ@CCF=A>=?EHIF>;BC?A2KHJGEHCKIGGGG;JGBJ4FAJBGHAGHDB=JIFJEIJEHJHGEJIEEE?HGBAHJGH=HHGE@BAGDID;CIGBIEG3HEKHIKHCIEH=GCGBFCEDHCAGEHJCF>7;9HJACJFAEJEFHHG?CHBFB8:%D:HBH?8AA/FHKGAJ4BE<7IIGJJGHE8FCCBAHCD<>@JK>HDDGC?CBIICC@EGGIFIHKEIGGC@HDIAIDKIIHDKK;@AHKJFCFEGGIHGJB5??FC@7JFCBGC;E;GHCIG9IBHBI2=CBB0GHF2BFJ@JHC@;E:IGIF>HBGGCIFJB>KGHHF8G@@<@KFGIF:IFFG>(D?GJICFDHJ$:>BDAEECBIJDIHHF?EI?CDGAGGEBGGGB<:?CFBBEBH??@CF8HJEEK@B;FDG?IDDHIK5GK?HHFIGFCACHFHCID@JGAB>GCF(G=IDE9DFG7FG8>CKJ>6EFHJ=:B@EDAHAIKDIHEH:HDDCBJK=JHD@FBFG>EGDE.C@6A>E=JG;D4G3E@@FGE@JKHHEH@DFHDF/AJEEHKDKBFEJJG?HH<=D=FHF@BJH>@IFH@A9BD3>IIIJ=F8GEGB2A@FC@=9=4D;BD?HJJIFADA,BEG?=BF?@:FEGGB?6FA?@@B54=GEGJD;GEI?F>A0?EC>H@CF3G?IIEJAAG>7:CC=>6<>AD.?=>8?>B?;88&9A8GB?.7B=@C::>FA8=B*C@H>C=B:<<@CE*;>:JEDA?6<@=EBB@A5>B@=->?G=>*>EA>GFHC86>B?8CGB9AGC7B?@=DH8JDEGDJEE;AHG3<31CBEBF>CC1GJAE:G@CA>G<>EBF1CB7BE@;078A@>@A>3=@>>=>B?*9=DCD1A78?>$6+9=3=88?A75D><42DBAEA>8=C@6?=@?(;8;<::-=4=@:?.3>?B@>B=B:=AA? @rCer/456/0_1764_CCS GGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACCGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTAGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTGCATGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAGAGACAGGGTGCTATTGTGGCTGTGACTGGTGATGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTTTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCCTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGTACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGAGGCTGATCAGCATGGCCTATGGGCAGATTGGTATGATCCAGGCCCTGGGCGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCACTTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTAGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATTTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCCCTTCTCATCTTCGTATATGATGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTAGAGAAGGAAACCTACTACTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGTCACCCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCGAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTATAATG + %*(077?><4/0<1=>38398?76;0&:9<>8%/106.-&555589*789$63AAA=7):=54@A=A592/)3698%64=;37<:><98:?A?@7B7C@59<=>;?@5B@86B0A=8:9807:0;=8?97@>A7><;6@7@3A=?.71<@495B08;A<3:19299>3;A>>;=?5?;5<<64A331=7@?AA?5C=;9AB>?=<>3ABAC?=A6><=?7?:.5<<@?;;;?B3><8:5<:A>6<<3?;<@AACAB0::BA:8;287A>;4>:6.=>6@3=><9=A;A;9@?=@9B78.;:<9=;406<<;B;:<68=A=9==C4>??<794><@:>4><=;*;968<8;B?:0;9:5=?3;679:/3?2/5ACA>>3=::;;67>=56=0325>?9:;A1B;@B3???::A(;:;855;412?)0-88=8=?@>*()<>;6?/7>??<490*0?>+5=7?;?9@<.:7.=<<>@:<./B1&0554:@=?6;(;4&<@?=<023;0;=6@=C7@<=8228;>@=1?<9=378=%5:297+47;2?95?785;<*9<:&9-=9<7@=7@608=2>=9=<>8=',6@C>?;4/4>>>9>1<=;8-3;<4:B=:-(6?=1,=A?B@B@2;:5?:51-30<:72A>?8=<+?:>9=@A:48A7@===>?;<=;?6:???A=-:>?/6864?:7?<9?.A?;9<<;@7>>873<;77>=+;>;@A<>38?A@1:5264>=5.719@?>@76B==?:B8>4?7787;:@=3?2A=893;?=:2>>4?B88;94?>3=9:B:>7?93;<2@A>>;3:@:+5<:.8:48:5=<<=<==8879A>=?396:8BB<<2877>%668?@?7A;4=98<==>BB?014%8863)/%(88<67=;:;8986;?@;777>9?CB95<9:6;<;B=9=>:A<;:?B?=B>8<>@4;8'9=CB;;=<.@;86>?579?4:>69098A:A@A&>8&'4:+783;=-?898;4>=;;<(?>:=19??5@?@;>?=@CCAA0>8979>ACCAC?A@AC?>>8AA9A7A9/:<:9=7=>?=?CA;=?1B@BA:A9=>@*:>AA=8AC:A/1:@0=@8;<';:495:8A4;8:?C;@>+;=;:??BBAA@>CA;8<==33;6>3>=4/89.:9:9:.9A=6A;<;/@@@44:::@8:?>@<1?9=5?:=>6<><=>2?7<85+73:+A>23564146*3+1+488>??>>97>==AA@9B1;:61?<;@>AABB<;3>C<;<=B9@)5>,<:31+AA@@79B=99BA)=>=79:@8A2;6=<8?>>@68:@=8A=7=;:67<79?39<<9'::867:0==29>7?7;/:B?7;23&47,-??>:;0<:8+88:7:-<<,@:90879>:;>6@9?2=-AABA>AC2:9===@>=<>B=>A7;5CA:?B>9A;0;@><<:*8.9>>-@?AA=B29:=9=:>.<9BA;=6??89;35 @rCer/459/1634_56_CCS ATGGGGTAGAGCTGGAAGATGGCGGCGTCCGTGGTCTGCCGGGCTGCTACCTCCGGGGCACAAGTGCTATTGCGCGCCCGCCGCTCGCCGACCCTGCTGCGGACGCCAGCCTTGCGGAGTACGGCAACCTTCGCTCAGGCGCTCCAGTTCGTGCCGGAGACGCAGGTTAGCCTGCTGGACAACGGCCTGCGTGTGGCCTCCGAGCAGTCCTCTCAGCCCACTTGCACGGTGGGAGTGTGGATTGATGTTGGCAGCCGTTTTGAGACTGAGAAGAACAATGGGGCAGGCTACTTTTTGGAGCATCTGGCTTTCAAGGGAACAAAGAATCGGCCTGGCAGTGCCCTGGAGAAGGAGGTGGAGAGCATGGGGGCCCATCTTAATGCCTACAGCACCCGGGAACACACAGCTTACTACATCAAGGCGCTGTCCAAGGATCTGCCAAAAGTTGTGGAGCTCTTGGGTGACATTGTGCAGAACTGTAGTCTGGAAGACTCACAGATCGAGAAGGAACGTGATGTGATCCTGCGGGAGATGCAGGAGAATGACGCATCTATGCGAGACGTGGTCTTTGACTACCTGCATGCCACAGCATTCCAGGGCACACCTCTAGCCCAGGCTGTGGAGGGGCCCAGTGAGAATGTCAGGAAGCTGTCTCGTGCAGACTTGACCGAGTACTTCAGCACTCATTACAAGGCCCCTCGAATGGTGCTGGCAGCAGCTGGAGGAGTGGAGCACCAGCAACTGTTAGACCTTGCCCAGAAGCACCTTGGTGACATCCCTTGGACATACGCAGAGGACACTGTGCCTGCTCTTACTCCGTGCCGCTTCACTGGCAGTGAGATCCGCCACCGTGACGATGCTCTACCTTTTGCTCATGTGGCCATTGCAGTAGAGGGTCCTGGCTGGGCCAGCCCGGACAATGTGGCCTTGCAAGTGGCCAATGCCATCATCGGCCACTATGATTGCACTTACGGTGGTGGCGTGCACCTGTCCAGCCCACTGGCTTCAGGTGCCGTGGCCAACAAGCTATGCCAGAGTTTCCAGACCTTCAGCATCTGCTATGCAGACACGGGTTTGCTGGGTGCACACTTTGTCTGTGACCGAATGAAAATCGATGACATGATGTTCGTCCTGCAAGGGCAGTGGATGCGCCTGTGTACCAGTGCCACGGAGAGTGAGGTGGCCCGGGGCAAAAACATCCTCAGAAATGCCCTGGTATCTCATCTAGATGGCACTACTCCTGTGTGTGAGGACATTGGTCGCAGCCTCCTGACCTATGGCCGCCGCATCCCCCTGGCTGAATGGGAAAGCCGGATTGCGGAGGTGGATGCCAGTGTGGTGCGTGAGATCTGCTCCAAGTACATCTATGACCAGTGCCCAGCGGTGGCTGGATATGGCCCCATTGAGCAGCTCCCAGACTACAACCGGATCCGTAGCGGCATGTTCTGGCTGCGCTTCTAGGCGGGAAGCCTGTGTAAACAAGAGAGCTGGGCTGGGGCTCGTGGTCCCCCCACCACAAACACAGCACTCCGGCTCCTCTAACCTGTGCCGCAGGTGACCACCAATAAAATCTTCTGC + HDIII=;FJEIIKKIGIJGCKHHIADCDIC>FI?ADC$DHHHK;KEFFDCJDFJGGFKIIDJDHDJFFIKBKKIHIIJKJKJHKBJCBKEJBJFHFDGF@HDHJIGH7JKGHGFIEF7FHJ@IKKKJKHIJ@JIKKKCGCIJIIB=GHI?J=IEJJJADH;CH=JKCFKJHBDFIIAHKCFKKK,JFBGJJJGDH6J>=KAFHJDEBICKIJFFAHAFDHJD5KCHD-CDFJK?DCJ:CGDIGE@?BD?FJ?BF;GF>8EF@CFA;6GEID?A9<8E@76.767B8D>CGDG@)CEAB6===C@C@:=7;98DEE@?IE40G@>AD1GCBFIFI8KDBEJ=FED9J?H@<9CJI;DGDD@C@F7@EG>BDCGCGHEAF?B949G=GHGDB:5CBG@EBACBHCCCB@D74C=I;GEHJJIHI;KGIDDIHJFHKGGFCJ?CIJJKJHEBAJBC??D4:D@JAC6FJEG=K=HHF/CDEHFGGGGHGGBGKCFFAIA?BH3HJK-GHCHF@EKK=KEFH@IABGIHIGJGA@KIIIHICHJ.J4@IIJCD8EGKICJFKBH<;74=KFHFKAKJI@JKIGE;KFGEHBJFIKIHFFGJBHHEJJ;HCKFHIIIH>FJJJJJHCGFGDDC=HK8EIBKDFE4HJKHFJIFG=J?GBHCIIGIH=;HI1,85@ED8FJG0FBFFE?ICAD@DEGF7EF?FBBGH@>8?@>;)1=,6CDGGGF@A@H=ACGDIF>@D.>A@5F@IDBC3EH>GE?HIIHHGHHEGEAEEGA:??D?JIIBFGHCH@BAFEF0?F?95?<4?ID:HG.@E?FFCIGIFE>@7CEB>CIIIDAB=D7B>@CHICAFFCFEAD@FFBB=ICG=39ACDE@=?:@?5.8A5=@=D8?E:ECH?BBA;C>;B>74DAC<?=;9:=>=;<1)?==;;9531.6@3BFCEFFBBBEFBE?C4E<>?3;AA;A>BE:ADB=@=D::C7=DA?:?BGDBD=GGF9;43B=;CC??(A=:E@FD1<=CACEED?A:EA>FHC=C6JD=D?EHBH;F1<=E;C4BF @rCer/462/2863_59_CCS ATGGGGGACCAATGATGACCACTGGTGGCGTATGAGTTATGCACATGAATACCATGTTTCTAGAACTCTGAGGTCCACACAAATGGGATCTAGTCCATTCATCCTTTGTGAAGGGATCCAATGACAGGTATCAGGATATGCAAGGATCTTTTTCGGATTTTTGTGTTAGTATTTAAAAAATACTATTTAAAAGAATCAAGGCAGGATAAATAAATGAACGTATAAACGAATAGAAATGAAGAGAGTGAAGCGTTGTTTATTGCTAAATATGTATAAAGAAAATGGACTATTGGTGTAAGTTAGAATGGATAATATATGGATGGAATTTATTATGTCTTGGACTAAAGATGACATCAACTGTGATGAATAATAGTTATTACTCTCAGTCAGTTACACTTTGAAGTTCATTTTATTGAGAGAAAATAAGCAATATTTCTATAAATTATTATTATTATTATTTATTACTTTGAGACAGAGTTTGGCTCTTGTCACCCAGGTTGGTCTGCAGTGGCACAATTTTGGCTCGCTGCACCTCAGCCTGCTAGGTTCAAGTGATTCCCCTGTCTCAGATTCCAGGTAGCTGGGATTACAGGCGCCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGATCTTGAGCTCCTGACCTCAGATGATCACCCACCTCAGCCTCCCAGAGTGCTGGGATTATAGGCGTGAGCCACTGTGCCTGGCCCATAAATTTTTAAAAACCAAAAAGATAGCACAAACGAATAGTGGAATATATCAGTCAGTGGAGAGAAATTCTCAATCTTTTATCATCTTCTGCTTTGTATGAAGATGGATCAGAATGAATGCATCAAGTGGGCTTAAGCATTCTGCTTGATGGAAGCTGTATTGTGTTGTGTTTGAAAGAAACTAACAGAAAAAAATACTCGAAATGTGTGATTACTGAAATGACTGACTGAAGGTGAAAGCAAGGATCAGTGGAGAGAAAGTCCCAGATGTCTGTTCTCCTTCTTCGTTTTAAAATCATCTGTTCTGTCCTGTATTTCTCACACTGGACCATCTGAGCTGATTTAAGAATTCTTCCATGGTTATGACTGTATGATTGAATCTCTATAAGAGCTTGGAGACCAATAGTGATAATCTCGAGGTGATTTATGCATTCTTCCGTGGCCACCAGCCTTATGGTTGCATCTCTGTGTTAGAGCTTAGAGATCAATAATGGATGCAGCAAGCTGTTTCAACCATTCTGTTGGGATCAAGATTGTTGTGTTGCCTCTGTGTTTGGAAAGAGACAAGAATGAACACGCTCAGGTGATTTAAGCACTCTTCCATGGCTACGAGCTCTGTGGTTGCCTCTGTATATTAAGAGCACAGAGATTAAACTGACTTGAGAATTCCTCCTTGGTCACAAGCTTTTTGGTTGCATGTCTGCATTAGGAGCCTAGAGAACAATAATGAGTGCGCTTGAGCCGATTGAAACATTCCTCCTTGCATCTTTGTTCTATGATTGCATCTATTTGTTAGTAGCACAGAGACCAATAATGGACATCGTTGTTCTGTCTTGAGATCCTCTAGGGTCACATGCTCTGTTTGCACCGTGCTTGGAAGGAACCTGCAGACCAATAATAGATGGCCTGTGCCGACGGAAGGATTCTCCCTGGTGACGTGGTGTGTCTGCTCTTGATTGGGAGCAGGCAGACCAATAATGATGCACTTGTTATGATTTGAGAATTCCTCCATGGTCATGTGCTCTGTTTTTATCATGGTTGGAGCCTACAGACCAATGCCATGTGCTCTACTTGCACCGTTTTTGGGATGGAGCTGGAGACTAGAGTGAACAACTTGTGCTATGTTAAGGATTCCTCCATGATCACGTGCCCTGTTTGTACACCATGCTTGGGAAGATACATGCAGACCAATAATGGACATACTTGTGAAGATTTAAGATGCCTCCAAGGTCACGTGCTCTGTTTGCACCATGCTTAGGAAGGAGCATACAGACCAATAATGGATGAATTGTGCACCTTGAAAAGTTCTTCCCTGACCACTTGAGGCACTTGCATCACGGTTAGGCTCAGGCAGACTAATAATGGACGTACTTATTCTGATTTGAGGACTTCTTCATGGGCACGTGTTCTATTTGCACCATGCTTAGGAAGGAGCATGTGTACCAATAATGGAAGCACAGAAGCTGGTTTTCACTGGTTAAGAGCTATCTCTGTGCTAGAAGCTGGACACCAATTTGAGACGGGTTTTCACCATGTTGGCCAGGCTGGCCTCGAACTCCTGACCTTGTGACCTGCCACCTCGGCCTCCCAATGTGTTGGGACTACAGGCGTGAGACATCATGCCCGGCCTATTCACTCTATTCTTCAGAGAAGATGAAAGTCCATTTTTTTCCCAAAGTATCCAAAAGTACAGTTGAGCTATGTAACAAGTAGAAACATAGAAGATTGTATGGAAACCAGAGTGCATCTACATGTACAGTAACTAATCTTAAAATTATTTGCATGATCGTCATCGTGTGATTAAAATGACCATGGGAAAGAAGAAAAGGATAAAAATGCAACTTTCTTGATTTAAAAAATGTAACTGGTGGGTGTGGTGCTGTGGGCATGTAGTTGCAGCTGCTTGGAGGTTGGCTGGGTGATCACTTGACATGGGGAATTTGAAGCTGTAGTGTGCCGTGCTTGTGCCTGTGAGTAGCCATTGCACTGCAGCCTGGGCAGCATGGCGAGACCCAGTTCTAAAATAAATAAATAAATAATAAATAAATGAATACT 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5-3259*8:/:558514:;:7(973..*2=<=5/35;/93,6:8<68?;88<,=3/:9%==;2984:<=:34,7;5&8;99=+=>>.8>>::<>?9;=8)67<2::1<;9:2>?4;8;0<*9%:3;:37<9200+3:;99*63=:===;:75%58*68:;3+/287+:8-4-/*15-/2%6514-98%-98+14674824*5971358:/9662.396666.35536::154702&847-424767994378;+52:-:;652896(10:70%,*5%0/,1%.527096;3;67568-8748875.:39882924059655934&79+*:56740.;6;65/';728-33-(4673690413458;933'982:4.7146.7955389'7;*995%6;/7:7:756+244%96'673//73/'88/850#',//*975762%82292151.2--3(0-+#1/$2353+4,3+6-43344'1&23)55597864'8:491;87:8768:66'376,$278%:5(5680226.5$17/25.5:3+06-;87742444:1445,54/,674346*-,35324-.766)36.4647*4/53(59.8:-8396534',32&887,*7229987+442526875630&89)*'1%-9:934)61.62109569:/7513687::76(98.-3(-1+&/05/6917:2366857'99:.876/16+9;9515:586762-5'99495894.5069/6522-4085&,-74(400220$+06490-.67'7(('7856532/)&,.13&+9853.530,0)67,4/278820)8630.0'+)/9..'2381+&'%&14'345;9871448/:25/7:3317;508;;89;7;67::851/3/;9926721&/-326890%025032157)&$2'4//)7283.57999588+56759889-81982:640-99:98096)-8632295,111136%289(;3678525/-959479(5,'5&368917-1591097&;5598:6983,675%54:9.89;498631.083485(),,446828-20$7:798:7'2:669.:328.3+.5.7.45623.1500767254466185.0(520-34.63.4937(0856'5)86548474%,5::955///799+1-.2-:07916.8/775%-:559;6;::6619977798:81:76:.2+/1)7887,75966'5948:3535:4:9:5::9899)3;59.3:4778918:/4(-.'98;995+3',9197&97:787::-53:912,86'.-20%/38.9226.3/39)49468/94745-+'81302:;66275:6::592999074:5254.).530:4/-6.+8344:8::958:-1595.6.759666-7532)9*-'98:77-:97454$7$1,5:89436/605;8::758:4516863'33&78+65/)*4:977-7:9:3:6447:9587;93')*'9867:9543&(6/933878;:::7:98:::-/8289:8::8:42.94316345,2514/59455.33/644524&./'#,+&3598265434+4.8:641714/1,,0.45/19%24:/&(/.4.37641+0)8,976384'44&9)282-1)678;632;9-83'-)-&1:56:66524.86943,-,(0//-/13%/53778460852-1*6579005/,752*3*44.6-1056-7625)93/$072-49898846.96-2359878&'-106;7:84/(,83-0967-;69475:2*:9264536-3969757578889*88,574/20%)/,321'5779:9.8.35335896997844:780;30:3/&/749:99549887963-6379(68566653684:.7737/4./844:75.2.:2923.04:452/52,7*9::91:9;;43+43047*.2&:08%669%6751678597-5(&4./.847(/1&:-6&+843,*'02..(6'8866739::8-4+27::97':44587*96/89479)8769539;:73:2679769689349:/98/;9888:6*24464*6&7;:59576.(595644*,%5577,52:9717769464759-,::90-;2364680:6670*-607658-9361+6:7/544,2708,57-2735.285:8:;8663,(9:4.4.026/741*8677:6363799::559476948948:::6;766-9410443,077&3996558:093:857%80;33).4:4.24:595433-/1-200/527$68298:4:.472,/-65857269*887+54747578:9.5.595:7979;8600635963::678.7944447::4097788*944.4377977-/2&9;175249589:24:35447,9652945967228+,985%87:::8791056:69677.0-(;4116:964/3'081.9414885:7437:507;6684'62656/63323329:1)32*9856:883985-059:7:76;489174145913;4638::91:96715::248/:998/24551&8:773439,897/4761019:85937.76784556.8938857/938*6564+8%%103+69698139136:95868-:499::9246-4-09:9143(26/32(/5481/75-455839477799,0383121/428'995:::;7:6.2037/4/:'.*779-542(340+62:104/521%082-476/.269 @rCer/463/24_2016_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCTAGATGTGATGGCGTCACAGAAGAGACCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTGCTGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATCGTGTGACACATGCGGGCTCCACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAACAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT 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rCer/464/25_2477_CCS ATGGGCGGAGGGGCGCTAGGTTTCAAGATGGCGGTAGCTGAGGGTAGACCGAGAGGCCGAGTTGAAGGCCCTTACGAAGTGAAAGAGGCCGGGAATCGCCCCTGCCGCTTCTCGTAGTCCTGGGAGCACAGCAGAAGTGTTTTTCTTTTTTAATGAACAAGTAAACCATACAAATTGTCAACATGGGACGGAGATCTACATCATCCACCAAGAGTGGAAAATTTATGAACCCACAGACCAAGCCCGAAAGGAAGCCCGGAAGAGAGAATTAAAGAAGAACAAAAAACAGCGCATGATGGTTCGAGCTGCAGTTTTAAAGATGAAGGATCCAAACAGATAATCCGAGACATGGAGAAACTAGATGAAATGGAGTTTAACCCAGTGCAACAGCCACAATTAAATGAGAAAGTACTGAAAGACAAGCGTAAAAAACTGCGTGAAACCTTCGAACGTATTCTACGACTCTATGAAAAAGAGAATCCAGATATTTACAAAGAATTGAGAAAGCTAGAAGTAGAATATGAACAGAAGAGGCTCAACTTAGCCAATATTTTGATGCTGTCAAGAATGCTCAGCATGTGGAAGTGGAGAGTATTCCTTTGCCGGATATGCCACATGCTCCTTCCAACATTTTGATCCAGGACATTCCACTTCCTGGTGCCCAGCCACCCTCTATACTAAAGAAAACCTCAGCCTATGGACCTCCAACTCGGGCAGTTTCTATCCTTCCTCTTCTTGGACATGGTGTTCCACGTTTGCCCCCTGGCAGAAACTCCTGGCCTCCCCCTGGTCCACCTCCTCCTCAAGTCGTGCAGATGTATGGCCGTAAAGTGGGTTTTGCCCTAGATCTTCCCCTCGTAGGCGAGATGAAGACATGTTATATAGTCCTGAACTTGCCCAGCGAGGTCATGATGATGATATTTCTAGCACCAGTGAAGATGATGGCTATCCTGAGGACATGGATCAAGATAAGCATGATGACAGTACTGATGACAGTGACACCGACAAATCAGATGGAGAAAGTGACGGGGATGAATTTGTGCACCGTGATGATGGTGAGAGAGACAACAATGAAGAAAAGAAGTCAGGTCTGAGTGTACGGTTTGCAGATATGCCTGGAAAATCAAGGAAGAAAAGAAGAACATGAAGGAACTGACTCCTCTTCAAGCCATGATGCTTCGTATGGCAGGTCAAGAAATCCCTGAGGAGGACGGGAAGTAGAGGAATTTTCAGAGGACGATGATGAAGATGATTCTGATGACTCTGAAGCAGAAAAGCAATCACAAAAACAGCATAAAGAGGAATCCCATTCTGATGGCGCATCCACTGCTTCTTCACAGCAGCAGGCTCCACCGCAGTCTGTTCTCCTTCTCAGATACAAGCACCTCCCATGCCAGGACCACCACCTCTTGGACCACCACTGCTCCACCATTACGGCCTCCTGGGCCACCTACAGGCCTCCCTCCTGGTCCACCTCCAGGAGCTCCTCCATTCCTGAGACCACTGGAATGGCCAGGACTCCGAGGGCCCTTACCCCGACTTTTACCTCCAGGACCACCACCAGGCCGACCCCTGGCCCTCCCCAGGTCCACCTCCAGGTCTGCCTCCTGGTCCCCCTCCTCGGGACCCCCACCAAGGCTACCTCCCCTGCACTCCAGGTATTCCTCCACCTCGTCCTGGCATGATGCGCCCACCTTGGTGCCTCCCCTTGACCTGCCCCCCTGGCTTTTCCCACCAGCTCCCTGCCGAACCCTGGGGTTTTAAGTGCCCCACCCAACTTGATTCAGCGACCCAAGGCGGATGATACGAGTGCAGCCACCATTGAGAAGAAAGCCACAGCAACCATCAGTGCCAAGCCACAGATCACTAATCCAAGGCAGAGATTACTCGATTTGTGCCCACTGCACTGAGAGTACGTCGGGAGAATAAAGGGCTACTGCTGCTCCCCAGAGAAAGTCAGAGGATGATTCTGCTGTGCCTCTTGCCAAAGCAGCACCCAAATCTGGTCCTTCTGTTCCTGTCTCAGTACAAACTAAGGATGATGTCTATGAGGCTTTCATGAAAGAGATGGAAGGCTACTGTGACAGCTTTTGATGCCAGAACAGGCTTCTGTTCACAACAGTGGCCATGGAGAAAGAAGCTCTTATTAAACTTAGATGAAAGAGCTGCTTCATTGTCAGGGTATTTTCTAATTCAGTTCAAGGAATATCCTAAAATTTAGCCTTGTTCAGAATTTACTGCACATAAAAGAGGGTATTTCATCCAGAATAGATCAGTTATTGAAGCAGTGCTGCTAACATCCATTCCTTTCACACCACCATTTTCATCCTGTTTCTTCCCTCCTCCAGTTCTTTGGAAATTTGTGATCACAGGGGATCTTAGTTGCTTACTTGTTTTGACTCTTGTGTGCTGTGGGCACTGGGTAGAGATTTTTGAAAACAGTTTATTTCAT + 3+(=<<:=;*7:;=>;:8+3,78:8:62;>1>;;647<7;2;*;:<87<47?><<5==<47;)<(:08;:2/*;7;)0$98995584=19>:8=:/:<<68<:=;<185=4>9&9950.*:8=<<;;::2:20:983<<9=;56>6<;7>5=9(4;;7-877;;=<4787953<;;9;/::;99?8:6099+79:8:>5?;;;$7752;7;38*=719051?>9;7=.2=?3;=8=>;=>:<:88??<5?=2:6&58:;;=<=8=?8=;:9:?4;>=>=886687*4:55/86=692779$:812:.676/<;::;965/,42,*68;;595=:3=67*4.83908:2>?><;;6'5.786;==6?9?8?=338438:81.6-829=<9927:4<:)<<98994==:;889:1<7;:;>?:57:7<77=>9<>>;?>:;%548555617/-:486:=:??59::>=8;.:96046;:88759=<8=>99<96=3<<<<,97/$:6<80:57>;>%.3>:<5;8?;45=::968-=7%35789=2<88<::2;076759:461520;*1-7=7-9083376=,;5;;36497:44&/-<<=%<9=.2:-387<5=:378?57;=(;82;8;1;9<=2:11==5/202<<>7>>:0<;;5=>>:6;?67>1>9;?99:16479%64:;518>==0:=;5:08==>?98/9<077:<76;:7<:;=9:.'18?<:5;;9;%:&'89=61=?<=8:=:::(48588::;,::57==)469<4:=<83;3)/4222197:24;9>71??:<>::.47<<9;;->>==2;:8?37<;>;9&19;8=;?<::9582>599>4=<556;;:7>0>699/88;96=47<;77>=>;;;;2052,369+>738899345.98::9:6796%4821<<97>=:)>=86;>3:5===3;8=9><>;8;99&%0;<;:8699&31;:*;;;.9:19;;9:?31;>:=;666<4;5??98:;=457;)475=):89:72:35'6-%19999>8=?:8105>.<7?,;?;6;+>==:<>;?=:<>7:97)0558983478><-<27)::1528/:=9;<016(5/<-><3>48<<36;4;'1.52=8:8>7915335:83<><9838>46-94;=:7>>9;?>:9<36==<45=7=;:'<;64<;>;364;?785;19A$28?3B93=>>7C5<=508=B9???4?./@,<;>;68475&13.-5>38==:@><438<&:;=<<<:A3>=2;B:>??A.9;&@<:69-94,:5/>95A<277::A6A@.::-78&9??<<@=(3.639=59:@@1<=6>?&69782:?5);:A?2BB@.,7'9;'24,96=?>9C==9=1<<2<;9>3>?==5=/25)87A;2;(/%46>=:3<=C=<8?>&835;919976=73;?;<3:83:56<<&;-'9;1@>3639=4&5;:31=+541)5;76)+-7CA97<.<88;>;>0+43)44-99&<644=/7;=):90.8;:=3792%57A@/@=A/?*787?A8>49962B@4=<334-768:2==912':--4:/::(6><8:+.2920'427897)8329722>95*4+8940;2%/33/.6+535&799,>>:79;>2'2147164';90>;<8?:39::=(340<-99881<=3>:>;>=;>>8=4<4)81=9>>>55=84;69-;;9358/68*436;9108<7:<8*72>;3/:>78086'0218::08836;3:/5:+31=2>?=88>7==9>=:2):<:<85:7:;86<.=4477<25;=1:34?=:<=::4?25:;11=36:36-29197/<766755?-38977<-.78./7=2;7:>>969<889>7&,:%4242569<:>:?=569=>4-2/::9;>96:79848')&*,#$+/3-415953;74=::8=/767*291813;:9934*870&+82,0346.032899><<85:=9>96/2/1122713'.398++25.383:6/7>3091=466996;(54>72798:75%7718:96967484272/1*.-6267738>;;27)5;:179+6839+135<68<<8'78:0,,)50478*<7;=-89-4>81:*==6?3=;<7?;<:?:09)9%9831+75=0:3=6071,7.=<4;=)953=725,76389/406772;:54569=>5:4;643<%6/351615/8969(+.1&(.1;11774.8722926/5;4*76:=69>:5<6:96813;=72980<44<>:'.6761;0--451;88;9671=<6.807088=95=88>7$99.0358=9?;-<1/0;0-3+88==:0**300,/515+*;779:;3>9+8#203886*4>32<:;8>:?262(6<0717?14=<9$66437<><=85:3>8,3:774@;2<<29/.==;;<4@708598385=;;>B?9%$7463584;39166;<@>>?<:69,B3-4;3:9234;:B6:9ABB>=>9*5/;;@B;/<<=/CB<<@.<:,7<59>B?><8-?7=48>8;<=>798;?.9?9+<7;3<=:689:A6B@6>664=>A3?<>CA77+8@-9259+2:;1;<:;>3<94<=9<5:;:,@;7A=&8986314:5;937?>9:>=8?:44<76A=1<<7A65=A=1:A::3:<;A46;B3&&'64/>8:/98469:/46,-+1?>5(#8527/<76'95.1?;988<<<65280<'57(6@/33777*''3.8-88;8:=59>.5:=9:876,55996>2:=<7;B6BABC>;9+<;>4<6<3:@:064>98=476=B;,;9:742*A4:9137:58C8:;E@?4>AD=C>==CF2@E?7AD@DF;DD??;<%+>3;5:ED59=G6?A<>ABAB;?%=76AD8B;:@ACBC:>?<25&3@EDFBEFF<;AEEAFAEA<%19A<9?:>B=BF=F?18>B::0=D:CB2F@<'7DD7AAB<@;?BDF@C@DA=C3C1:8@=AAG8=-CCA:8;2D>C>EDAFAB;:34052<>=1205888:@EA;A7CDD:B>9;A3?=/?,69>AE$CB4>1@2>A<)7;;A.:A?AA=>;EBEA?@2C?@1>>E=>A4;17578@@9*569:72>E?C?>1@<>9BBA9??5;C;+851?9=&<:>9D1DD??CCD@?59<>3DB8B?CA:;,;4CA7=@8@AE@:?*834@.?;1731;=;@ABA@A::<@@>=8>==&;<566<8=;==?BBB:->%6*1<<@6>6(=9<=<&79379=6>B???=:A-07>=::>59;<@B;?7=:>;;=7?C6<%?9&;=.-5<7183@KEKE;HGC&JKEK@IIK>JKKKKKICKKBKKKKHKKJKJBFKHJJKIJIKKHKK6KJKKEH@KJGKIJKKHG:JIC;KKHKKKEJKKIHKKHKKKKDIJK'FCCHJ2F?HFGAJIJ;HH9BJDEGJDGJJDIDKFKJKIKKIKEDJKKFJKJJKIIKJ4KGJJKKKDFJ.JJHEGKKHCIKDKHHKHJKFICJ9KKKEEH5HHKE.AGH>IKJJDJGIEEHCJIJ=?:KI4GGBIHJJIJGJJJBGJJAKIJJ?IK=KKGKGJKKIKK>KEFJCEJKAJ=KKJJIJGJKKJJK6JJKHFI5HJJJIJAKKEIKGHGFKKJKKDGKGBG:F@IEKKKKJGKJKAKJKIKKKJKIK:GKKHKKKKJKK@KHKKKKI=KJ4KKIKFKJICKKKKJIGKKDKJIKJDKHJJCKJFGKBKE@KGIDKKKKKKIJJK9JKJCKKJ>IJKJKKKJFHKIJJKAHIJIIJ?JKKKEKFKKKJKHKKJKJGKFBJAKKEGJIJKIKJ?IGJJHKKJIKKIFK%GGJDGGIJKKKFKKKGK:FDJHKKKFGIKCJJFIKKKGKKJJGKICJ/@JEKKKIJJGJGKJGF?KHKCKIIKDEKEKJJ;DFIFB?HD:HKJGKDK?KKJGEGKF?J4HKJIG9F9JFJKKAKK3BJDGJK;KIKJKKIKJIGJKKJKKKKKKJDJJ@GC/J>=DF/KIIKKKJKKKIKEKJJJJIJJ=0JKIJJI+K:K?JIICJHIFKCDKKKKKKJKJKCKJGKBJJIKJ>KJKDJIK2KKIBJKKKKKIKJ7KKIFJJIIAKKJ@KKGIFH=HGKGKIJJGGFD>?0HHJJIKGJBKIKJKHIKFKKJKKKIFKKFJJJJHK?KE/KKKEKJJ=KKKJJKHIJ@HHFBKDKKJFKKIHKGKJIEKKKKKKGKKBKJKIKKIGKGG9KKKIJ:AJKKKKAKJHKKKFKBJKIKKKIKJAA=KKKHHKJKJI?KKJ'KEEIFKKJDKCG@GGHKKHK?KDKKKKJKIIK@GG?HHKKJJ+KKKGKKKKIK*KFKK @rCer/467/751_60_CCS GGTAGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGGGCACAGTGGCCAGCACTTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCCTAACCTACTGACCACCTTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + /&,%$&$$)%((%0-0/(0--,&+*'(+)--111,*&0/220/'/((&,,-211/%%,/1*+/*-+()*-1,,+)-/',.)(&)$*-++$*1,60,/0.*)%-)-,%)))#'.,150,+-1/,$*++&00.53240+1.0/4*-40(%*,10211-.((.%,.(/1503,'#)&,2+5../1&/)*20(-(-4/(-12/641.,'&,&/0',&//1&447')8;2);:9,45.'949:666-6462:437?=;<61::-258?;81502602+4167+68.61254-$721$:4861072,6,*5%0/*2,,)79:-9'2=;714.%1+++.*&-,,+.10//.//-0/.2,*,2.6.3+24484*4559043/0-3)11*1-22'5:9-964:.&.4+/2(743+6,097-*.'//.8155/$437.4.+.9:,3.04/0402/%2(%1/0.1/47522)+/12$,4-7,4104*06:0*33.3-168:679<472882783..2<91-3)41*33';4<3534+--8&+%23//13$5256.6/39-18.>8844,8':72899/89=/69936469*128.;>99=:4662*37:590.573:79568-7>98/)*/.==6:0953+9/072(05174:<-=884(.520)031875,(:<=AC4/:148;/1?>7-2./,9A48<5& @rCer/469/1634_95_CCS GAGAGAAGAAGCCAGCTAACTAAGAAGGCAAATGTAGGCACAAAATACAATAAATTGGTATAATTGGAACCAGCATTTGAATTTGATGTAGAGCAACATAACGTAGAAGGTGCCTATTAACATAGAGAGACTCCTTCATGAATTACCAAATAGAAACTTCTGATAATACATACTGTCATAATAAAATAAAGGAAGAAGGAAATATATTCTAGCATGGCAGCCACAATGCGAACCATCAGGATGAAGAGAACTTACCGAATACTAACAGTTAGAGCAATTCTTTTCCAAGAGAGTGAATGTGGCATTATTAAACTGGGACTCTAATATAAGCACCAGGAGGGTGGAAACAAAAAATGCCACTGGCCTACTGCTCTGAAGAGCAAAAACTTGCTCGTCGCTGCGAGGTAATCATGAATTACTGAGACGATCCACATATCCACAGAAGTGCCTCTTGGTCTAATGGACGAGAGAAAAGAAATAAAAATGTCTCCAATTCCTCAGTTACCAGAAGAGGGGAGAAGGTATTGCCCATAAAAAAGCATGTAGGATGGTGGAGAAATAGATGGTGGGAGAAGAGAGAACAACCAATAAACATTAAGTAATCATGTTTAAATAAAGATATGGGCTTTAGCATATTACAAAGTAAGAGTGTAATGGAAGCCAAATATTAATATTGCATACAAGAAACCCATTTCTCAGAATCTTAATTTTTATTTTTTTTTATTTTTTATTTGGAGACAGGCATCTACGTTTTCATAGATACCTAGCACACAGGACTGGGAAGATGCCATTGGCGCAACACTTGGCTCACCCATACTGCACCCGTGGGATTCACGAGCGATTCCTCCTGAGCCTACAAGGCCTCACCGGGAGTCAAGCTTAGACGTACAGGCACCTGCCACCACTGCCAGCTAAGTTACGTAATTTTTAGCTAGAAGATGGATATATTCAACCATTGTTTGGCCAAGGAGCATGTCTGGAAAACATTCCTCACCTCAGCGTTGAACTGCACCGCACTACGAAGACCTCCCAAAGTGCTATGGGATTAGTAGAGCATGAAGTAATTATTGGTCCCACAGACCATCAGAAAGATTGTTTAATCTTATAGAAACTACCACTTTTGATAGAGAGGAGAACAGGGCACTCTTGTAGGGGCAGCGCCATGTCCGAGGTAGATTGGTCTTTCACGCCTCGCTGCTCTACCTGCTTAAGTGAGGAAAACAGTCACTAGCAAGACAGAGAGATTACCTTGCTGGAGGCCGGTGAGGAATCGTGGCACGACCAACTGCCACCATACGCAATGAGCCCAGTCTCATTCGGGAAGCGTCTGAGATGCTCAAGCTCAGGCTTCTACCACAGTTTCCAAATCCTTAGGCACGAGGAGGGCTTATTCCGACACACGCTGGCTGTTGACTCTTCTGGCATGAAGAATAAGGAAATGCCATCACTCCTGCCAGAGTTATGAACTTGGTTAACAGATTAATTAAAATAAAGCCTGGTATATGTCATTGTTAAAAAAAAAAAAAAAAAGAAAAAAAG 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%*%",,#-"%.&-..)&"#--)"--#.('-%**-,"-%")"*,+$-#$"*&'&".'-+&"+$"#%&)#+,+&""$-%&.#,$&(&.&..$....%,"-)"+"..(-'-.*..*..//*)()..-./-/(...-..*.$.-"#,#%-&(),+#'#'*"&+&&'#&%%),-$-".+#,.()-#))#&(+#$#,%"*,-%-'"*+'/-/.*/.#/,$-.%"'-*,#&"--#$.('.-///#.*$/."--#)$%!.'#-%.."..-%%-..#.%.-.-"(".(".'++,,,.."+,-.-%./...+-#.).&"'"#,&+(#')%(*"##).'-..--"-.(+"&$,&%+&+-%##&"-./*--#"/)+,.&,.&..../),-..*#"*(+.,$(,-".$*-$,+$"""&."-&."...$))%..."%&,"#-,&&-.$(.-+..-/',)-(''-,,$,&"+$$,,-',&+$)"'#!"#*)%%*#"##"--,,&'&&*.$,--,.(.),-&,-.#-+,)(&.(&#&$-,*"%"*+",,(**+...*/...#*(..*-.),,-('("""%-)$-&+",+$---,-(+%&)'%#&+"%,*.-%%...-%/,//-/),/*.//+,.#../*#+-.'("/$/.#.)"-"+"'.."--#/..-+*.+/,-(.-+//%+*/.//-*/('*.-#...$%,,+..%*/.)-/.-/,.(""-+**"$-(**'%*%*#-*)%++#.+,-++)..).""%,.+#...$)+-$+".(."-)!(#-","-./*#.-.)#+$&#--%"+"*.*-.-''$,,%+.*-.,%+''#("...+".)+$&&-("*',.""--+//.)"-++-&."#+-.$--".'$-,,",+-%#.-.""-..-%....#,---/*'.-$&&%+--,&%..*&-....+,/*./..#--('**&&"),+.#..&.*"%-%.,$'$%%-..%..)%.**("-.)#".$...-..*"(',.#.%-.../....//&,.'."%--/,".,/,"--"-#.#.(,-.,,*,%*,,.,-$#.%%//).#.--#*&+--$-+.(&.)#-*&!"+('%(,-",*$"-...*,//+).()"&,.,"+,.#..#,--"-,&#.'++.%),&#+#+'#*$&")-&(*....-#....*%(,...$,,$./.,&".,*-&-".(&&($++,..$/)--#"#%(#&*---$..%.*$..(.--(*$#&#..../*"-()%--*,$$-,--##--#+.((,)%&+#'#"-)%*$',.,.".,+%"."-.,,-,)..+*.""..%"..,-#).++#+,/#,-,#-%"-',&-#.*-#'...*.'%.&-%/..-./*$.)#$,",.+../''**+,,.++.)".*""$.),%"+*(..*#.+$,..#$,(*"$-"*"-",+."-.$-,+..#-#./.#-'"**+,#*&&.'*#+.-/).",..&../,(.#*/.+,--)"#.,.#.//..*.-.*/"$-.*+.-*'+/"+.,-'#$&--).-(('')&'&$&%'$%('(("*'$)')($ @rCer/471/25_1949_CCS ATGGAGACATTCTGCCTAGATTTACTAGCATGTGCCTTTGCCTTCTTCTCTTTGATGGAACAGGATGTTCAGAAGTCACGTTTCTGTGATGTGGTGGATTCCCACTGGGCTCTGGCCCTTTTCCTTTGGATCCCGTCAGCGGTGCCGCTCAGCGGCTTGCACGCAGACTTGCTGGGAAGAAATGCAGAGCCAGCCTGGGCTGCCCACTTTCAGAGCTGACCTCTTTAAGCCCTTGTGAGTGGGCTTCACCAGCTACTGCAGGGGCATTTTGCATTTGTCTGTGTCAAGAAATTCACCTTCTCAAGCCAGTGAAATACAGAATTAATTCATCAGGACTGAACGAATTTGTTTATTTCCCATTAGGTTTAGTAGAGCTACACATTAATATGTATCACCTTAGAGCAAGAGCTTTGTTCCAGGAACCAAATCACAATTTTCAGCCATGGAACAATATATCCCATGGGAGAAGACCTTTCGGTGTGAACTGTTCTATTTTTGTGTTATAATTTAAACTTTGATTTCCTCATAGTCCTTTAAGTTAACATTTCTGCTTACTGCTACTGGATTTTTGTTGCAAAAATATATCAATGGCCCACATGAAACATACGAATTGGATCATGATAAGCAAAATGAAAGAAATAATGATTAAGGGAGAATCAAGTGACTGTGTTACACTGCTTCTCCCAGGCCAGAGAATAAACTGTTTCAAGCATCGTCTTTGAAGAGTCGTGTGATGTGAATTGGTTTAGAATGGATGCACACATCCATGCACACTCAGGATACAGTTGGCCTAATCATCAGTGGGGCATGGGTAAAACTTAAGAAAAGTTTCCTCATGCCAAATTCTAATTTTCTCTTACCTGTAAAGTAAAATTTAGATCGATTCCATGTCTTTGTTAAGTACAGGGATTTAACATATTTTGAATATAATGGATATGTTGTAAATTTGAACTTTGAGGGGCAATACTATTGGAATTATGTGGATTCTAACTCATTTTAACAAGGCAGTCTGACCTGCATAAGATCACTTGAATGTTATGTTTCATAGAACTATACTAATCTCACAAACGGTCTATAAAATATAGTAGTTGAAAAAATTTTTGTATCAAAATGTTTGGAAAATTAGAAGCTTCTCCTTAACCTGTATTAATTCTGACTTGAATTATTTTCTAAAATTAAGAGCCGTATACCTACCTGTAAATCTTTTCACATATCATTTAAACTTTCGTTTGTATTATTATTGATTTACAGCTTAGTTATTAATTTTTCTTTATAAGAATGCCATCGATGTGCATGCTTTTATGTTTTTCAGGAAAGGGTGTGTTTGGATGAAAGTAAAAAAAAAATAAAATCTTTCACTATCTCTAATGGCTGTGCTGTTTAACATTTTTTGATCCTAAAATTCACCAACAGTCTCCTAGTACATAAAATAGGCTTAATGACTGGCCCTGCATTCTTCACAATACTTTTCCCTAAGCTTTGAGCAAAGTTTTTAAAAATACACTAAAATAATCAAAACCGTGAAGCAGTATATTAGTTTGGTTATATACATTCATCTGTAATTTATAAGATGCATGGCCAATGTTAATTTGCTTGACAATTCTGTAATCATTAAGTGATCTCAATGAAACATGTCAAATGCCTGAAATTAACCAAGTTGGTGAATAAAAGTGCCAATCTGGCTAACTCTTAGACCATACATACTGATAGTTTTTCATATGTTTCATTTCCATGTGATTTCTAAAATTTAGAGTGGCGACAATTTTCCTTGCTATGGGTTGCATAAGCTTTATTTTTTCCTTTGTTTATAATTACATTCTTTGAATAGGTCTGTGTCAATCAAGTGATCTAACTAGACTGATCATAGATGAAGGAAATAAGGTCAAGTTCAAAACCAGCCTGGGCAACATAGCGAGAACCTGTC + KK%KJKJKKKKKKKDKKKJKJKKKKKKKKKKKHHKKKKKKKKKKI?KIKIFKKKKKIKKKKDKKKIKKKKKKKKHKKKKKFKKKKKIKKKKKKKKKKKIKIKKKKK;KKKKKKAKHKK;KKKAKKKKHKKK>KKKKKKKKKKKKIKKKKKKKKKKKJKKKKKKKKHKKKKKKK7KKKKKDKKKKKKKKKKKKKHKKHKKKKKIKKKKKKKKKKKKKKKI;KKKAKKKKKFKKGKKKKKKKKKKKIKKKKKKKKKKKHKKK=KKKKHKKKKKKKIKKKKKKKKKJJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK0KJKKKKKKKKKKKKKKKKHKKKGKJKKK4KKK8KKFKKKIKKFKJKKJKIEKKKKKKIKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKK9KKJJKGKKIKKKKKBKKKKKKJKDKKKKJKKKKKGKJKKKKKKIKKIKKKK&KCEKKKKJ>KKKKKKKKKKKKKKKKKKKKGFKKKKKKKKKJKKKJKKJKKKAKKKKKKKKKKKHJKKKJKKKKKKKDKKKKKIKKKKKKKKKKEKJKKGIKKK5KKKKKJKKK7KKKKJKKJ@KIKKIK=KKKKKKKJKKKKKKKKKKIKHKKKKKGKKKKKKKJKKKGKKKKKJKKKKKKKKKKKKAKKKKKKKKKKKKKHKKKKKKKKKKKJKKKKKK7KKKKKKKKKKKCKKKKKKKKKKKKEKKKKIKKKJJKKKKKKKKKKKKKIKKKKKKKKKKKK@KKKKIKKKKKKKKKKKKKKKKKKKKKKKK2KKKKKJKKKKFKGKKKKKKKKKGKJKKGKKKKKKKKKKBKKKKJKGKK0KKKKCKKHKKKKKKGKFKKEKKKKKIKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKKKKIKIKKKKKKJKKKJKKKKIKKKKKKKKKKJKKKKK(KKKKKKKKKKKKKKKKKKKDKKKFKKJKKKGKKFKKKKBKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKJKKKKK;KKKKKKEKKKKJKJIKKKKKJKKKFKKKKKKKKKKKKKKKGKKKJBKKKIKKKHKKKKKIKKGKKKKKKKIKKKKKKKKKK6KKKKKKKKKKKKKK9KKKKKFKKKKKHKKK;KKKJK5KKKKEKKKKKKKJKKKKKKKKKEKKKKKKKEKKKKKHKKKKJKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKFKKKKJKKKKKKKKKKKKFKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKJKKK@KKKKKIKKKKKKKJKKKKKKKKKKKKJKKKKKKFKKKKKK5KKKKKKJKKKKCKKKKKKKKKKKKKKAKKKK.KKKKKKKKKKFKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKJKKCKKI2KKKKKKKKKKBKKKKKKKKIKKKKKKBHKIKKKKKKKKK>KKKJKKKKKKKKKKKKKIKHKKJKKKIKKKKKKKJKKKKFKKKJKKKJKKKKKKKKKKGKKKGKKKKFKKKKKKKKKKHKKKKKKKK=KKKJKKKKBKKKKKKKKKGKKKJKKKKKKKKKKKKJKKKKJIKKKKKJKKKJJKKKKKKKKCKJKKKKKKKJK:KKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKJKKKFKKKKKKKKAKKJKKKKKKKKDKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKK'KKKKKFKKIKEKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK@KKKJKKKKKKKKGKKKKKKKKKKKKKKKIFKKKKKJKEKKKHKKKKKKKKKKKKKKKKKKKKKKFKJKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKK?KKKKKKKKKK5KKKKKKKKKKKKKKIKKKKKIK @rCer/472/2366_58_CCS ATGGGGGGGTTGACGGCTTCTGGCGGGTGGCGGTGTTGAAGGCGAGAGCTCGCTTGGCCCGTGTCGCTTCTGTCCCAAGAACCGGACGGAGAGTGAGGGCACGAGGGTCGCTGTCGGGGGCTGTCGTCTTCCACGTACACGTCGTCGTGAGGAGCGCAGTCCGGACTCTCTCGCAACCCCTCCGGCTCCCTTTCCGCACGCCTCGAGGCGGCGGCGGCCACCGAGACAGCAGCGCACCTTCCCCCATCCCTTCCCCTTATTCCCCCGCCCAAAAGGGCCCGGTCTGCGCCCCACCCCCGCCCGTCCGCCCGCTACGCCGCCGCCATGTCGGCGCAGGCCCAGATGCGCGCGATGCTGGACCAGTTGATGGGCACCTCCCGGGACGGAGATACTACTCGTCAACGAATCAAATTCAGTGATGACAGAGTATGCAAGAGTCACCTTCTCAACTGTTGTCCTCATGATGTCCTTTCTGGAACTAGAATGGATCTTGGAGAATGTCTGAAAGTCCATGACCTGGCTTTAAGAGCGGATTATGAAATTGCATCCAAAGAACAAGATTTTTTCTTTGAACTTGATGCCATGGATCATCTGCAGTCATTCATTGCAGATTGTGATCGTAGAACAGAAGTGGCCAAGAAAAGATTAGCAGAAACTCAAGAAGAGATTAGTGCTGAAGTAGCAGCAAAGGCAGAACGTGTTCATGAGTTAAATGAAGAAATTGGTAAATTGTTAGCTAAGGTGGAACAACTAGGAGCTGAAGGGAATGTGGAAGAATCCCAGAAAGTAATGGATGAAGTAGAGAAAGCACGGGCAAAGAAAAGAGAAGCAGAGGAAGTTTATCGGAATTCTATGCCAGCTTCCAGTTTTCAACAGCAGAAACTTCGAGTCTGTGAAGTCTGCTCTGCCTATTTAGGACTTCATGATAATGACAGACGACTGGCTGATCATTTTGGGGGTAAACTACACCTGGGATTTATTGAAATAAGAGAGAAGCTTGAAGAATTAAAGAGAGTCGTAGCTGAGAAGCAGGAGAAAAGAAACCAGGAACGGCTGAAACGAAGAGAAGAAAGAGAAAGAGAAGAAAGGGAGAAGCTGAGGAGGTCCCGATCACACAGCAAGAATCCGAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGATCTCGCTCCATGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGTAGCCGCAGCCGTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTCAGAGACCAAGACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCCTATGAGAGTGCTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCAATCCTTAAGCTTCCTATGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGCGACAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATGTACAGTATCTAACTTTATCTGAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGTTCTGAAAGTACAGTTTTATATAATAAGATGCTGATCTCTTTATTCTTTCAAGTAAGAGTGATAGTGAACAAATTGTGTTACTTGCCTTGGGAGTTTTTGAACGTTTGTAAAATGCTGTCTTCCTAGTCCAAACAGCTGCAGCTTTGGGCATTTTTCTTTTTAATTCTTCTTCCTCTGACTTTGTATCCCTTAATACCTACACTCTCCAATTGTAAGAGAAAGGGGGCAGGGAAGCAATATAGCTTCCATTCTAAGGCTGTATTCCTGTTATGAATTACTAGCTGATTACAGTTCAGAGCATTGATCCTGGAATGTGTGCCGGAGAAATTTAAAATACTGGGGTTTGTTTAATGGTGCCTATTTAGAGTTGGAAGTTGAACAGCTGTTGCATTACATACTTTTGCTTTTTTATTGAAATTTTGAAATCAAACTTGTCTTGATTTTTCTGTTCTGTTGAATTGCTATGTTCAGGATGTTCTTGGGGGTGGGGGCAGGGACTCTTTTCATAATAAGCACTTGTTTTATTTTGTGTGTGTGGAGTATAAAGGCTACACCCTTATTGTAAAAAATAATAATAAAATGAAAAACAATCAC + IBKKKKIC(I7EKKKKJK@KKKKKKK)GKJIJGECH,JKHKJIEIKJJKKJKGKEKHKICBHHDKKKK>FIKKKJ8KJKKIKKIFDHJ@DKKJJHHJKGKIGKKKIGGKJEJHKKKKKK5KKGJCJJFK?KJIKJJEHJIKJJJCJKIKKGIKJIKKKKKKGKJJJK;GKHJJJKIKKK/JKJKIIIKK>KJGKKKKKKKKKEKG?JAKFAGIKJKKKKKJJJI9JKJKKKKKKJKKKKKKKKJJJIKI1KK?KJKJKJKJJKJJKFJKJ0KJKJKJIHKKKKHJJAJKKKKKKCKEFKIHGJKKDJJIJFIJJKJJKKKKKKKKKKKJKKJKKKGJIKKKJGKKKKKKIBKGIJKBKIK8JJKKBDKJKK:JKKKKDCIDA=;GIKDKKJKJJJKGKIDJK>JJJKBCKKKKGKKEEKKJJKIGKKKJKJIDDKIJKKKKKKKKKJKIKFKKKGIBJHKKJKK>JKKJCJKKJBKKKK1K?EHIFBBEKIKKK0KKJKKKKIKIEKKKJHHIKKIIKHJKEIKHHIEKEJ7JJKJKGHKJKIFGK?BJJEGJDHKGJKKEGFIHHHCFKKHHKKKKIK?JFIJJIKJJHIKIJKKIIFEJDKJKKIGKEJJFKJKIHH?DHDC1HKGKJ?>HEKHKJH?JKKKKKHIKJKFJKJJ8HKJKKKKJDJHJKKIKJEJDJJKHGJKIGKKKJKKKIJKJKJKKJEKJKKKKJKKKH=EDJKKKK7HKFHKKCKKK>HKKFKKKGDJKKKIKKBJHGJIK9KKKKIKKKK9HK@KIKKKKKKKKKKKEIIKKKJKFJHKK%DHKKK:KIKK@IFFJJKKJFKKJKK1KKKKKE?KKK@GJKKKK4KJJKJJ= @rCer/474/25_3042_CCS ATGGGGCAGTCGGACTCCCTCCCCAGCCGGCCAGTCCTCCCGGAGGAGAAGGCGTCGCGGAGACAGCCCGGGCGGGGCCTACCTTCCCAGGGCCGGCATCATGTCGGCGGCGCAGGTGTCCTCGTCCCGGAGACAATCTTGCTACCTGTGCGACCTGCCCCGCATGCCTTGGGCCATGATCTGGGACTTCTCGGAACCCGTATGCCGCGGTTGCGTCAACTACGAGGGCGCCGATCGCATCGAGTTCGTGATCGAGACCGCGCGCCAGCTGAGCGGGCGCACGGCTGCTTCCAGGACGGCCGCTCCCCTGGGCCGCCGCCGCCCGTCGGGGTCAAGACAGTGGCCCTGTCGGCTAAGGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCGGCCGCGGCCGCCGCGCAACAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAACAACAGCTCAACCACGTTGATGGTTCCAGCAAGCCTGCGGTGTTGGCGGCCCCGTCTGGCCTGGAGCGCTACGGCCTGAGCGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGGTGGAACAGCGCAGCCGCTTCGAGTACCCGCCACCGCCGGTGAGCCTGGGAAGCAGCAGCCACGCCACGCGGCTGCCCAACGGCCTGGGGGGCCCAAACGGCTTCCCCAAACCAACACCGGAGGAGGGACCCCCAGAGCTGAACCGCCAGAGTCCCAACTCGTCTTCAGCGGCGGCGTCTGTGGCGTCTCGGCGTGGGACGCACGGTGGGCTGGTGACGGGGCTGCCCAACCCGGGGGGTGGCGGAGGTCCCCAGCTTACTGTGCCCCCCAACCTGCTGCCGCAGACGCTGCTTAACGGCCCGGCCAGCGCCGCAGTACTCCCCCACCCCCGCCCACGCTCTGGGCAGCCGTGGGCCCCCAACGCCTGCTCCCCCAGGGGCTCCTGGGGGCCCCGCTTGTCTCGGGGGTACCCCGGGTGTATCGGCCACGTCGTCCTCCGCGTCGTCTCGACCTCTTCGTCGGTGGCAGAGGTGGGCGTGGTGCGGTGGCAAGAGGCCCGGCTCGGTGTCTAGCACAGACCAGGAGCGCGAGTTGAAGGAGAAGCAGCGCAACGCCGAGGCCCTGGCCGAGCTGAGCGAGAGCCTGCGCAACCGCGCCGAAATGGGCCAACAAGCCCAAGATGGTCCGCGACACGCTGCTCACGCTGGCTGGCTGCACGCCCTATGAGGTTCGCTTCAAGAAGGACCACTCGCTGCTGGGCCGCGTTTTTCGCCTTCGACGCGGTCTCCAAGCCCGGCATGGACTACGAATTGAAGCTGTTCATTGAGTACCCCACGGGCTCGGGCAACGTGTACTCCAGTGCGTCTGGTGTGGCCAAGCAGATGTACCAGGACTGCATGAGGACTTCGGCCGGGGCCTATCCTCGGGTTTCAAGTACCTGGAGTACGAAAAGAAGCACGGCTCCGGGGACTGGCGCCTGCTTGGGGACTGCTCCCCGAGGCCGTGCGCTTCTTCAAGGAGGGCGTGCCCGGCGCTGACATGCTGCCCCAGCCCTACCTGGACGCCAGCTGTCCCATGCTGCCCACGGCGCTGGTGAGTCTGAGCCGCGCCCCCAGCGCACCCCCGGGGACCGGGACCCTGCCGCCTGCGGCGCCCTCGGGCCGGGGCGCAGCGCCAGCCTGCGCAAGAGGAAGGCCTCTCCGGAGCCCCCGGACTCAGCCGAGGGCGCGCTGAAGCTGGGCGAGAGCAGCAGAGGCAACAGTGGATGGCGAACCAGAGCGAGGCGCTGAAGCTCACATGTCCGCCGGGGGCTTCGCGGCGCCGGGGCACGCGGCAGGGGGTCCGCCTCCGCCGCCCCCACCTCTGGGACCTCATTCTAACCGGACCACCCCACCTGAGTCAGCCCCCCAGAACGGTCCGTCCCCATGGCCGCCCTCATGTCGGTGGCAGATACTCTGGGCACAGCGCACTCGCCCAAGGATGGCAGTTCCGTGCACTCTACCACTGCGTCGCGCGGCGTAACAGCAGCAGCCCAGTCTCGCCGGCCTCCGTGCCGGGGCAGCGCCGCTTGGCATCACGTAATGGGGACCTGAATTTTACAGGTGGCGCCCCCGCCGCCTAGCGCCCACCGGGCATGGACCAAGTGCATCCCCAAAACATTCCGGATTCCCCCATGGCCAACAGCGGACCTCTCTGCTGCACCATTTGCCACGAACGTTTGGAGGACACGCATTTCGTTCAGTGCCCGTCCGTCCCCAGCCACAAATTTGCTTCCCTTGCTCTAGAGAGAGTATCAGGCCCAGGGCCACCGGCGAGGTGTATTGCCCCAGCGGTGAGAAATGCCCCCTAGTCGGGTCGAATGTACCTTGGGCCTTCATGCAAGGCGAAATCGCGACTATCTTAGCTGGGGATTTAAAGTGAAAAGGAAAGACCCTTGAACCACTGGGCAGCCACCTCCTTTGCCCTAGACCAGCTCCTCTCCAATCCTGAGGGCCCCTCCCCAACCCACCTCGACCTCCCTTCCCTCACCCCCAAGGTGTAGAATTGTGAATATAACAAAACTGCAAAAGTTAGTCTTATGTATAGACATTATTTTCGTCGTATGTTTCTATATTTGAAACAGGTATGTAACTTCTTCATTTGAAGGATAAGCTGGTTTGTGTTAAGCAGTATAATATCGGTTGGGTCATTTGCATCATATTCGTTAGCATTTATTGGTGGCAGAATGTTTGCCTAGGTACAGAATTAATAGCCCTTAGCAACGACTGCTGCTGGTGTGTATTTTTGTAAATGTTATGCACTCTGAAAGGAAACACACACACAAAAGAAAAATACTTTTTTTTTTTTTTTTTGCCAAGGCCAGTGTTGCTGCCTAAAAAAAGAAAAAGAAAAAAAAAGATGCTATAAAATGGTGAAAGCTTCCTTCTAACTGCCCCAAGTGTTGAAGTCTTCACTTTATTTTGTTCCGTTTTGTTTTGTTTTTTCTGTTTTGTTT + 5+$26671339-4,20/991&2558027183:7214:40:6-73/2&4580758462727398<5;2;9'47,%63/03+35732$59212:2:-71588:=;/02933:87==5;41/6413462;?==+4969=62)4<9118?6>=;>;;2:7=0;98959186?,;/?>0>8.,889128:<,;95960718,449576,/67775-:44:9=7;=99>;98?=78=;?=/<>::2<=71082617/56:;;:25033981<78=>8(59+6>0;7.:7=953-/>8=42:372=22>700?<84(5<8>><=>7:40;<:3.'578<>6:8;>8:5&9$89<>;87=948;4>/<2::;:5?=;?99:93;<><<8;77>>:<<5>5==>;>285-6;>><&88818+354,5+25577634737057689676*6+&*2485136-15/86.987:<19;7<:<=;:2/99+=7<78;0::7;:9,8-13964=4)6'6;3933*668906&766;8=/4<8334895156313082<4909:=;2=9:37;:1<73;82;;==6?;92>;;=9>:8:57:685:;:17>>=8551==8;?65<;:?<4-=?9-><&3)7::8/3289:75:38::6:6*6/147;::;5:85;;69:4;;-5794;558.80+-7564'8+-5;252463.89&(858986687497;59(4;84,75049'5-8:9-4/9826:89469:9157405:742*25,6540'74.37693/5-.6:/148862925453.-.02-618:*8654:90:9444&36.8999:41;958878#1-*//052979.865;::3/16.+.65399;:9;3;;7;4:24494:::7:438.%2,+5&%43635(03,/0042,(45836/692,:5(8883*804'35989*896:9.::835,41.1:96%457954;::3:9&8861/4&021,8653457924*658:4592,9.(-25256521)2/28:/0+88.27+2,130137+6.'88.1.%6232#0(1683754-61::0:,9:770565149(09866277*33-855344(05672:438;190.4:.*979.655'.0::91:57684:022-*(476936&.197)4'.//--4,%#**+23,:197(45186.690359479795&&(333587/9687/,2:559;5277/575574759829*8:::1993611;*488;913762-2.-%1655534',-.104*2*.,,22-,0120010,/3/43//0+31133,+.2-202/242111&12.0/1./15*2.-.2-430031011.26989118.7;644240-'.,2)0013*83686.759-179;3.2284-../2$'/39-2'(1)4)09749164.//-'4,)886-3471380-81.3.02,5:5/363,.45:-+24&977+2-28-&'2101&339;:1$4430&35634)63;40-/53077/8-/4294(5514564;66676955663465184;9950355823./5959048662.14.940*/430+1-//+12442+600/*.344:.4736/.5::8787:4/%/0/4)4545-3'443&2398.9687765029909823-5417%771:9631&465724:(-5340854&5652:-853-0:3314/95865694)'3-&--3'0245::865.4/231249/2'434-24.,+,1*-3867.7;798;997:39588725616523/3)+',14.%/04022&)2%-21/44739402-2&--56296499045/'76300*43.92-65.44/59:98.166.'2/23047)-603-5)1+22694499:24946230,(-'-132225133-2.0612&53403)11850988734986'3126953)+-*.*0)022-3,256447844,>82<4>52-5>:4.99=:.,6+7685*087::=<98'-+5449836/730:7949:6&9/*958::;9?8<7=8(1<>60/5=:::52619><;=?-;<92629886>78??;89;:83<'37545+3741=85)::7857:<2;28:87/504)6+9:73:1;;382:-421+4,>>:->=>03.:;=6:66>06:>=8:6:593<;1696;=6:9;;9&57/66*044$::.:=:814=77-662;0/8-89;;85,69573;=80<=1?==56?;7+<;:738:497:9%93168<*;:.987,;9503216)2/1&,&(9+792'<=-564:*:<=6%<12+*/49+=;:798'7:<<7*96<:(8686268:==5+><;4547<3809(619:27+8<4:;:6):8(<<;6'::;7=%0230<;584%7//+216+:8:62+79=91;442625,*1/877=9=:8:7::'570237:$:;9.-69><57<7=4:75885:*266+5=:7:-:396*/.72-+.,-&79:8=>=>9>75>=99>;0;:8?>;3??98<4>69:?*5(6<184335,3.78=:9911115:9:(0/>/6-'04)7;85&1123/,-+7,<52;;&+-,%3*;))87>=+9.5%::349<76>1<89=1>&8(88;8%63,<:3:)995617;.28354875880)#<<::52$06685852510-263:8>?9;/>;09<657432,1>85%754./56&395:====;7:::76:79+96/,*/=2&,5%94,=;=;757%1166,$2985:99856/11431.04:8:=;1(:=583;/;+7/+%66:7&533/7;>82:9/;:4/0:68;)91.+/69:798=>9;?;=17840%3:<;9;<=)57:>/== @rCer/480/2276_61_CCS ATGGGGGGCTACCGCGGCGGGGCTCTGCCCGCCTTGGCCCTCTGCTCTTCTCGGTCATGGAGGCGCCAGTCGCCCGCTTATTTCTGCTCCTGTTGCTCGGGTCCTGGACCCCGGCGCCAGGCAGTGCCTCCTCCGAGGCACCGCCGCTGATCAACGAGGACGTGAAGCGCACAGTGGACCTAAGCAGCCACCTGGCTAAGGTGACGGCCGAGGTGGTCCTGGCGCACCTGGGCGGCAGCTCCACGTCCCGAGCTACCTCTTTCCTTCTGGCTTTGGAGCCTGAGCTCGAGGCTCGGCTGGCGCACCTGGGCGTGCAGGTGAAGGGAGAAGATGAGGAAGACAACAATTTGGAAGTACGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCATAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAGATTTCAGTCATTGTGGAAACAGTCTACACCCATGTGCTTCAGCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTTGAGGGGAACCATTATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACCAAACTGGGGAACCCCACGCGCTCCGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTCCCTGCCTATAGTCAGGATACTTTTAAAGTACATTATGAGAACAACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAAAATGTGGACTTGAAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGTTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCCATCCGTTCTTTTAAGACCATCCTCCCTGCTGCTGCCCAGGATGTTTATTACAGGGATGAGATTGGCAATGTTTCCACCAGCCACCTCCTTATTTTGGATGACTCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACTCATTACATCGTTGGCTACAACCTCCCAAGCTATGAGTACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTAGACCATGTGTTTGATGAACAAGTGATAGATTCTCTGACTGTGAAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTGCACTACACCTATCTGGACACATTCGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTGGAACAGCACATTCAGGACATTGTGGTCCACTACACGTTCAACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTCATCATCTATGTTCGGCTGGACTTCTCCATCACTAAGGATCCGGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCTTGGTCAACAAGAGAATAGGCTTTACCGTCACTTTGACGAGACTGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAGAAGAGCCTGGAGACCGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGTGACAGAGTGAGCGAAATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAGCTCAAGAAAGACACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCCCTGTAGCCCCTGCCCGCATCCTCAGGGGGCCCAGGGTGCTTGCACTTTGCAGTGGCAGGCAGAATGGGTGGTAGTGGGAGGTTGTGCATGGAGGCCAGTGAAGGCTGACATCTGTAAAAGGCCTTCAAGGAAGAGAAACCAGGCCCTGCCTCAGGCAGTGTGAGAAGCTTGCTGTTTGTCCTTAAATCTTTCCTTTTTTTTAAAAAAAAGAAAAAAAAACCTCCAATTAAAAACAAAACATCTTTGTGTTTTGAACAAAGGAATTTTCAATATTTGATTGGTATTCTGTTCTGAAGCTAGGGTATTTTTTCAGCCTATAAAGCCCCTGTTTTATGCCCTTC + C@EEFB8,@AD97BA=7@BDD7C;>C>ACB>AF<;>@?>B3BAD6?GAFGDE=C;D8A5C@:@9;;BBCDAF;;<16DB:;:CBGFC>E9E@B;@<)?B?C?D>FCDCEC3B:;E:60'8:DE1?4D@>=<8>E@8C6>CCAE:@:;B>>=><;=B?4>AC;A>@CB968BA=;4*>4<.:A;=C=BA;@:7@8>4><65<9=AA6?;;>@@(A?>?9BA9A5?B0A@@==9ACB<@=@=?BCA@0@:AC@B@@A)A;?A>947A9:@A6A<7>6;?%8?<8+<=>=C@69<6*<><;9@A3==:>?>=?>=<,8.=??6>==8:;:<.:;8:;&?7A<=C=79>3>>B?A@A@?<>:A@=@3B><;:.:6:;41<B?CAA?A;2A6A=@<;)??:?@@C371=75:;86989=>?>4AB@;A@;:?6@B??:<<>@C=8<>3;<7@>B>A>>A>8.8A9>4?AB1AC;;8@:5>5:>>6C>A>6*50A@BA>@/@;;@A7649=>.9><<>B79>=?A@@+>A8;<;A@7?:AAACA>?;A>A?B:A3AB7BB@=>;?:6925A:=?>?A7A?@6;;388>?;8?B<<6=>>+32<6@;=<>;847.B<5A=:@@?;<<77-7>=>6B;88=>=CBA58761A1?:>6<21@BA@BC>CC@>A::(?1A=9?CACB;@A?>?A;@7=?A<=8:8462?=:?>AAA@>8@2;CC4C=A>>A?>?@:@A8B@<;>?>@A18.-8@=BAA>=AB?9?:B6A@,@<,:8@:=;<187>06:3/>::=9;>;58>;7=<>5<;82;<>>:;6<9?:*2=/>>5)8>>6=68=?;=/9?4>=:2;?=6:=)<>=;9<9?<<249:;6;=43)&%0:=:;187:=>868?<><>><564&=92=><2><>>>;9=?7<255;-7=884=659.;;2<9:?<;?=??7;>:;0244>;2=9:=;;=:9<75<99<4>;<75?5540916<::*9:6=?876355068;57<;?<>:=;=;8*:::3:68<+:33046:2?;<>428:?;8:=4<>6<6<>;6596:=>>:2;:5<>5<:>=7=<808>?=<=<:7:=562;<>4<3:0>:=>;>79<:?801<=4:72>==63>::59>=88,3;6=6<7?8<:>8826+9?:<;;-286=709:4%5928?:288=9:>1<5<::6<89883;9=:9;;8==8<;>643215<8=>68==;52;53>8=6<;;::1:;)6819:4?>>:5>957*7933.1,9;<7>>>8><=6=>;:6;;:=>=;5886'87777>>559?2==8>>=49::7>;59>913>7998;:?:>;;;;;?3=6=?376<;9=6;58<848><=?;859=<34;989>>>>968>:<8;><;997=<<69;<=6;<><:85:<4=<;7*77792;:=<3714,=5:8<;489;565>=>?=;49;<:(67<8;?<99=9;50=858:3;=85639%8;7::;?>;78;5:/077=;=9<=?<=7>=99:=7;<6;48:>?7:?=<4);>>;><96=1?4<<<>?>?>:>>=66>;>?8?<>8=<;/87<<5?9?;=>3>>8=83:6=?:>7?::>??;>:6;;9;2?;=76:>831;9386>;572<>1:7=?===>>**;859<;'=<=>>==>8*?>=;8?;:6;<==:5:88&9><9<;,>=;;9=/8?;7=52;8><8<<.>?>3>:<8=5989187:84>:<:4>;703308;=<===1<88>87:=3>9:8<=.897<:0<<877'=:= @rCer/483/1860_57_CCS ATGGGATTTTGGAGCGGACAGAGGCCAAGGCCGGCCGGGAAGCCGGACCTGGGCGCGGGCGCCGCGGTGACCTCCCTTTGTGTGCGCCTGGGTGTTGATTGCCTCCTTGCACGGGCTGCTCGCTCTCGCGCGCCCGCGCGCTCGGGGCGTTCTGCACCTGCTGGCGGCCGTGCCAGGCAGCCGGGCGAGCGAAGGCGCGCGGCGCGCACGACAGATGACTGGAGTCATTTACATGCTAGCACGTGGGTGCCGTTTGCTGTTGCCTCGGACTTCTCCGTGCTGTGTTCTCTGGGTGAGGAAACAGGAGGCACTTTGCAGCCGACAATGAAATCTTGGCAGCTAATTGCAGTCGTGGGAGATGCCCTTCAGGATATCAAAGCAGACTGCAATACCTGCGTGGAAATAGAAGACAGAAAGGTTTCAAGACAACAGATGAATTGTGAAAGAGAGCAGCTAAGGGTTTCAAGACAACAGATGAATTGTGAAAGAGAGCAGCTAAGGGGTAATCAGGAAGCAGCCGCTGCCCCTGACACAATGGCTCAGCCTTACGCTTCGGCCCAGTTGCTCCCCCGCAAAACGGTATCCCCGCGGAATACACGGCCCCTCATCCCCACCCCGCGCCAGAGTACACAGGCCAGACCACGGTTCCCGAGCACACGTTAAACCTGTACCCTCCCGCCCAGACGCACTCCGAGCAGAGCCCGGCGGACACGAACGCTCAGACTGTCTCCGGCACCGCCACAACAGATGATGCAGCACCAACGGATGGCCAGCCCCAGACACAACCTTCTGAAAACACGGAAAACAAGTCTCAGCCCAAGCGGCTGCATGTCTCCAATATCCCTTCAGGTTCCGGGATCCGGACCTCAGACAAATGTTTGGTCAATTTGGTAAAATCTTAGATGTTGAAATTATTTTAATGAGCGAGGCTCAAAGGGATTTGGTTTCGTAACTTTCGAAAATAGTGCCGATGCGGACAGGGCGAGGGAGAAATTACACGGCACCGTGGTAGAGGCCGTAAAATCGAGGTAAATAATGCCACAGCACGTGTAATGACAAATAAAAGACCGTCAACCCTTATACAAATGGCTGGAAATTGAATCCAGTTGTGGGTGCGGTCTACAGTCCGGAATTCTATGCAGGCACGGTCCTGTTGTGCCAGGCCAACCAGGAGGGATCTTCCATGTACAGTGCCCCCAGTTCACTTGTATATACTTCTGCAATGCCAGGCTTCCCGTATCCAGCAGCCACCGCCGCGGCCGCCTACCGAGGGCGCACCTGCGAGGCCGCGGCCGCACCGTGTACAACACCTTCAGGGCCGCAGCGCCCCCGCCCCGATCCCGGCCTATGGCGGTGTTGTTTACCAGGATGGATTTATGGTGCAGACATTTATGGTGGTTATGCTGCATACCGCTACGCCCAGCCTACCCCTGCCACGGCCGCTGCCTACAGTGACAGAAATCAGTTCGTCTTCGTTGCAGCAGATGAAATTTCTTGTAACACCTCTGCAGTTACGGACGAGTTTATGCTGCCGACCCCTACCACCACGCACTTGCTCCAGCCCCACCTACGGCGTTGGTGCCATGAATGCTTTGCACCTTTGACTGATGCCAAGACTAGGAGCCATGCTGATGATGTGGGTCTCGTTCTTTCTTCATTGCAGGCTAGTATATACCGAGGGGGATACAACCGTTTTGCTCCATACTAAATGACAAACCATAAAAACCTTCCAATGTGGGGAGAAAGGAAGCTTTCCGAGGCCTGAGTATTGCAATACATGCAGTAGTACATCATTTTAGCAAC + HKKK3KKKK'KIJKKKFKKAJBK9KIKJKEKBKCB:KK*KKKKAKJKK7GKKAKFKKKGKKKJKHI)JKJK>KKK*KK2JKKJKKKKGJJK&6:K:IKKGKKJKKAKEKKJKKK(KKJKJKKGEIHHKKKKKKK=KKKKKKKKKKK+KKK4KHJJJK;KKKKKAKK0KKK9JK?KKJKIKK)-K0KKJKKKKAK?JKKIKKIKKKKJKKKIKJKKKEKJKKKKJJKIKKJKKK$JKIKKBIKJGKK*KKKKKKK5KKJKK6KK:KKKEKKJDK?K&B6JKHKHKK=KJKJKK4KKIKJKK4JHKBKKKKKKKK7KKIJKBKKKJIJKKK7AKKJKIKIKKKKKKJKKEKKKKKKK4FI,KKKKKJKKKGKKGKKKIKIKKHKKEGKJKKKHHKIJKCG@KKKKK?KIKIJKKHAKK?KKCKK3JK=?JKKKKKIHKKK4KJKGJKKCKIKKKKKKJKKIKKK)EKFHKKJ;KAKKKJKHJK9JKKK)KKKKKIKHKKGKKIK/KIIK9CKKKFCJKJKKEK>J=HK>KKK;KDKK7KKKKIKKKJK$@J&KKKKJKKK6EKHKKIEKFKEKKKKKK7DIK2F@KKKKFIKKKKKIKBKBKK5DBKIKJKJKKK/IKIJKGK/K9I0IBKJJK'JIKKBHKK*KK;CKKKKKGKKGK,-KKDFJKFJJK@IEKCKBKJJKK+>FJKKK>EK@KKKIKK>K3KKKKKJI5K7GIKK;HEJK@KFGEKGKKKHK3K)KFKEKKKKIKDKKKKDCKA>KKAKGJKK9GBKFKJKKCK1HKK(KKKKBKEBIKI?KKKKKKKKK-IIK;KKJKCJGEJ5KKJKHAIJ?KJKK2DJJKKKKKKKKK(FKKKKIKIKKKK*KKKKIJIJKJKK8DJF?HE4=IC.KB%JH?KJJ1IKKF4EJ9IFC.KHJF*KK&I/K@F17-KDCBGB76KJ2EKJCBFI*GG?DFKK3KA1FDFKK>KGGFJDKJF@HKJFKKGC:GE5KBGGKKKJ2KJH@KKKGKJ#HIGI+EKCKAIB2I;HD6HG>KH:KKGCKK+KDKKI@K?KKKGJHKD;KKGIKKCK6HKFKK7JFFFIE@JKKJK0JFFKI?KIK@J)G?I>DI@@9G;-EKB5GE:B=KAKJAK*KIKJH:I.K(KCK3KEI7CJBJF@DKECGG=@'JKK3D>JF2CKHIKGD'KJ6FGI<5'GHHJJF@BJI'76K4?85'HB?IGBKCIJGKKHIAKFGJEK>JKJ/JAJ%K0EBD<7I>FKDEG,JHE,IFBGKJIK4KFHK.KJAKCKIK;;GKKJIK@JIEKIJJ;K*K9KIIIHBFBEKHICG:J&FF:<9KHJ@@BGAFDKKIJDFJ8KD>K>KKBKK7KDKGHKKKJJGJ9KGJIJEEEJAFC@'=EHI9:8JK?GBCB?;HDDHFH@KCKEJJKJ4K9JFJGKC?4KC;@IAKJ=JD/H5KDDED@AF9KKJ9K$KKH4K5KIKGEBK+KK@G@FGKHJKFK=?)IKCH>KJEI>KKB3IBKKIFGKKKFFKGKFKACAF:IJ8JFJKDB>DKIKJIEA;DJIADKKAKKDB4KKK;KG(G7ADHCIKI=GK9HJCKGKJFKKJJGJBHIHK8JKKHFJH5KHKKAKK6KKKKHKKDKKKKBJJ6I@H)JKKKJBB76KJAJHJJKKKKCKKKJKKKKKK5JK8KDIJBJJ6KK3KKJ;JIBKHKJJKIJKIEKIK3KKDHC9AKK6K(JJ@FKKKFDGDEKJJ6KKHJEGK93<(KHKI/KKGK@KBKJKJF$B7>>?HJKKKKB0KCKK$JIKJKK6KKJK,KKJC=FKJKAF9KHKKBKKKK4EJGKEC6GKKKKJ=(IFJIIKJI7JC$HIJIEIEKKJKKJIKKG+KKKKHKJIHKKK1KKI7KKF?KG9KKIJGK @rCer/486/25_2135_CCS ATGGGGCAGATGTGCGCAGGCGCCTAGGGGGTGAGGCGCGATGGCAGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCCCTGGCCTGGGCATGCATGTGGAAGTGAAGGACCCCGACGGCAAAGTGGTGCTGTCCCGGCAGTATGGCTCGGAGGGCCGCTTCACGTTCACCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAACTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGTGTGCATCTCGACATCCAGGTTGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGTTACAGCTCCGTGCCCGCCAGTTGCTTGATCAAGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGTATCGTGAAGAGCGCTTCCGACTGACAAGCGAGAGCACCAACCAGAGGGTCCTATGGTGGTCCATTGCTCAGACTGTCATCCTCATCCTCACTGGCATCTGGCAGATGCGTCACCTCAAGAGCTTCTTTGAGGCCAAGAAGCTGGTGTAGTGCCCTCTTTGTATGACCCTTCCTTTTTACCTCATTTATTTGGTACTTTCCCCACACAGTCCTTTATCCACCTGGATTTTTAGGGCAAAAAAATGAAAAAGAATAAGTCACATTGGTTCCATGGCCACAAACCATTCAGATCAGCCACTTGCCAACCCTGGTTCTTAAGGACACAGGACATTAGTCCAATCTTTCAAAATCTGTCTTAGGGCTTATGAGGAATCAGAACCCAGGACTCAGTCCTGCCTCTTTTGCCTCAAGTGATTTTCCTCTGTTTTTCACTAAATAAGCAAATGAAAACTCTCTCCATTACCTTCTGCTCTCTTTGTCCACTTACGCAGTAGGTGACTGGCATGCGCCACAGAGCAGGCCCTGCCTCACTGTCTGCTAGTCAGTTCCGGGTTCACTCAGTGGCTTTGTGAATGTAAATAAGGGCAGGTCTTGGCCCTAGAGGATTGAAATGTTTTTCTATATCTTAGAACTATTTTTGGATAAATTATATATTTTCCTTCCTAGTAGAAGTGTTACTGCCTGTGACTAGCTCCAAACACCCATGCAGTTTCTGCATTCTAGGTTTTTTTAATTTATTTTTTTTGAGTTTTGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCATGATTTCAGCTCACTGGCAACCTCTGCTTCCGGGTTCAAATGATTCTCCTGGCTCAGTCTCCTGAGTAGCTGGGATTACAGGTGCCGCCACCACGCCCAGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGGACTCCTGATCTCAGTTGATCCACCTGCCTCAGCCTCTGCATTCAGTTTATTCACACATTTTTGGTTACTCCCATGGCAGCTCCTAGGATTTCAGTGGTCTGTGGCCAGAAAGCAGGCATTGGGTCTGATCTCAAGGCTGTATCAGAGGGCCAAGCAGAGTTATTTTGGATACCTGCTTTTCATCCCACAGGGCCTCAGAGTCAGAGGTAAGGTAGCAACAGAGCTAGCATGGGTTAATGCACTCTTACCCTCCTTCTCAGCTTTTATTTAAGCTGTGCTAAATGTTTTCTTCGAGGGAACCAGATTTGGTTCTTTGCAGAATTTTCCAGTGAAATAAAACATGTTGTAATAGCTGCGTTTGAGATGAAATAAGATGTTGAGGGCAGACGGGAGGCACCTAAAGGAAAAGAGGAAAGGTGCCTGGACTGCCTATGCAGATGACCTGGAGTGGACTTCACTATGGACTCGTGGTGCTAAAGCTTGGCTTGAACAGGCAGTCTAGGGGACATGGAATACACAGGGTGGTTGCTCAGTCATTTGCAAAGGTCAACCAAATAGAACACACATTTGCAAGATATCATCTGAGAAATTAAGTACCTTCTTAGCCATCTGAATCATAAATTTGAACAAATATACTTCCCTCATGCCCTTCTGTATAAAACTTAATACCATTAGTTCCCCATTCTTGACATTTTATTTCAGTTATTATATATTTATTTGAAATATTTATTAAATTACCTGACCCAC + ?<'?CE@B?FAHGIGGFE>@CB4DCH-HJID?CGHJIDEB;FCGHE.702:CH1AEEC=DFE@CDHFHE?HIHEJ:HH>BJFCFCJFFE?@C8HJ3GF=>;DI>IAHHGJE+HH&AEC>GECEEDIGEEEH(=HE>DAB8BE>GFDCBFEIFEIIHGGB-=9@EHEFAJAIAGHD85CGFJHI:IHGF6BBEIFE2?JF>GE;GHDGEEHIIIG@BFEGGI9HGEFIH:HED+GF?@EG;;EFDFDDF;7C/E@DECBECGEBBHG4FGAFEA@GFFG>HEBGDH-EABB@EHFIIHF=JIIBGIHCJFHEIFGFFBID8>F>EDIIA6HHDI-FBI=7HFIJE>HIBE6IF0DGBFFGHDCIGHIGHDFI1E?F:>DFDICHEIIDEFFHEG;FEHIGD4GI?AIBHHAA<1?EAJI9DIIHFC6GIHGEH>@=GHHGG7AGDDHG?G@GIEI@IH=EECAHH=BBCHCI7IEHDE7FFAIH@G=J;I?BB6EDEI2HDIEBCHI6JAHDAD:@GGIFI3JJ<.5C)DHFHC6C6FA:GB<+*HH.JJJJIDJGF%GHFE@?JJHD6HFDJIFBCGGCJ:A=GEJBAFEC-DG@E?EDIDDGCDHI:HHGBIHHGIII7>;FB5HI?DHIGEF3GDIDGHB?E2B<>?F?<EHGHFGDFE@IHI5JA=D@EC=DBIIHDIEE=FDJJGIHH@IDGHIHB@CCCIHGC@;,G?E7IJAJF7EABBCA9G@HIJIGDCJEGI>HF@C?,?GCFCG1@=H5A9JIFHICHJBCG?FJG?E1>EGG=G>HEFEGHFH6EEII3HHHGFH4%>C9>D>B-E>CDG=IEEB>?.EFC8='GHHFHGFIHFFI=E;HEGDFHID@;EIH'FCDIIGDEJE?F'?+IJGJJ@;HAHFF3JHJHFIEDEC.>AC>DII7G@H9F?EGG?IIDDHDIIIHGJCBGEC?HDAGFD9DCGEBIAABFCI@DGD?HE@>*I/DHHECFIIHGGIH>BIG)?>?BHADECEA9$AAADF>AACA&CGCGGEIF=HIJIF@CC0EFFEIDHCFEA@2IHG4IFEI==>EI>IBAHFHGIIHGKIGI6IE>6IGCC3=A5DHHG9HFHDC2,>CCG2HBHGJCHJDAIDI>BAFAE>>HECAGB%A?FADCGEGGE7BBEBGBBGCEEG;CDF@9D?B/=B*DB8?A;?EACB;B@:7B?D2C>@E>=C1;BCB?FA:DCADC?CEF(=;>>;@CDC4??EB1BB?FEF8?6357BCBDA)>BA=?BFG8FFE;C?@AC8G>A=GD@DDAC;FCBCDEBECFEE=.=A;FFB@?-A<@>CDDFB:;EF:EGDAAFF8B=?;AAC9B1;AD?F3CCCCF?A8DGAGB=4B75DFA@:CGGB>??@7@?BD8=BFCACE6=@F?EFCF<7GF@GB)BAE:BCFFB<=>'?AAADEA)B1>1?CEFB=@A>1@;BCEEC?BBFB:BBACC7C?AC@4<;BFEBBBA@EF@?F;@EC;C8B@GBCCEFCGA<9>4%7<@CD1CD>;DF>:@;FFEDBG@BDC1@C9C5C@B+CFFE@CB5C@E@E/D@?BBGGC=:>@B3=>14<@:BFEC@ACEBFE:AFAE=CED8FC@@=CEF48B'BHGC$DCB::HBFGJCIHFIDF?I@IFFD>FBJCBHIEC@GCDJFDJF7B@E=@FD+H??FHDCB?=AHBF==8DIHHBIFEEE@IIHCDFIIHBJC>GDDEBEE>B<>CEBFJIHE4H86B;@GDGBIGC;GGG?@D5HGGG4IHHFDG8D@;?CA;B?JI=JFAEA6FFC9E?/GEC5?3=?<@4BCB9BED?;?C:BBDD@3FF@FBB,:@8D6ECD>+GEBD?>DA9D?CD*@CBEC?*CF>FA0EGFFBACGBCBC->7?BAGD>31?A?8BA?E?6?B@ACCFBDBAE/A>@;AD:D)CA>@8(9559?B628A7=0BAEFA+F?6GC>E'B4@-'?>FGG=GD9EC;@E?5<9CDFG?DF9?=BG@CD:>=FEAE?FF@;EC26?;>ECGB=@;=:.E?6CA55=;5<0=DGFDFDC6BAFFE4@7BBFABEA,?;CB?:ECCD;D?F@3@C>FADCA=BBEEB@<8D>9:&@67&3=GFEGBA?BCBAF@9&DDAB=C=<(EDD=?G2+@DB&E3C>@D<;EA?A9?;B8FBA?BCAE?95=:=,6>>B<0:<9#9<>6@?@EB9F96B@A0FGGGGD55@B?>-BCF9:A=DFC;EC7EC?9DB.;<@>@A@F@@:DE5EB=:1B+9@C2AAG7BD&@BDAE;CC@FE6@@>FABFAC=@BAEB.AEEC@A@@FCECED>C2:B=%D8BEF::6A?4E?6C??@6;)>?9*=67A@C=>@?6?;(<4A;D;>8C>6D2BC;@E36>,BAAAG8;EB8AEDAF>B>?FC9FE?9D@@DCE?BBBEDFDBE>EECCC:<>BC59=?B=FA==A?>BAFF@:A=@BA@7AB3EFF=,C9<8D=@@AF?4CCEE<:4?FFF0E?F;G>D'E=2=@BA@>?:@>?FFAAEF?B6@AF7:@DEBCE>E;C45?F95DAEF@=4E:=CCFBEGDFDEFA=FFC=CE6BGEGB5BGB.@@B;=D=A=>:B?ABCDGE:CAAF@:8BDBBFD;GDFBB52AE@@@GD@CFC=3BE?1BGEA;D?E>D:EBBEDFAE?8@>F8G7$>CB69G.G7D0GGGC>D1D::FFADDFCDF>A@E+D:?BCC@B&ACEBB+FA$@B07:?*:FF?BGCA?A2EDB9A1FE?FDD4DCDBFEE8GGFEC8CD=D:93A<<=FBCE5CD.CFCC93@B@A6@< @rCer/492/25_2655_CCS ATGGGGATGTTGTGATGGAGAAGCCGCGGCGGAGCCGAACCCCGCAGCCTGAGCCACCTTCGTCATCTGGGCCGGGGCCTCGCCGCGCAGGAGCTGCCAAGGCCATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACGGAGGCCCCACACTGAGCCTACCCCTGCCTCTGCACGCTGCCCATAACCAGCTACTCAACGCCAAGCTGCAGGCCACAGCTGTGGGACCCAAGGACCTGCGTAGCGCCATGGGGGAGGGTGGTGGGCCTGAACCAGGCCCTGCCAATGCCAAGTGGCTAAAAGAGGGCCAGAACCAACTCCGGCGGGCCGCCACGGCCCACCGTGACCAGAACCGCAATGTGACCTTGACCTTGGCGGAGGAGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCCAAAGGCCTGATACACCTGTACTCTGAGCTGGAGCTCTCAGCCCACAACGCGGCCAACCGAGGCCTACGAGGACCTGGCCTGATCATCAGCACTCAAGAGCAGGGGCCAGATGAGGGAGAGGAGAAGGCGGCAGGGGAGGCTGAGGAGGAGGAGGAGGAGGATGATGATGAAGAGGAGGAGGAGGACTTATCTTCTCCCCCAGGGCTGCCTGAGACCCTGGAGAGTGTGGAGGCCCCTCCCAGGCCCCAAGCCCTTACAGATGGCCCCCGGAACACAGCAAGAGTGCCAGCCTGCTGTTTGGCATGCGGAACAGTGCAGCCAGTGACGAGGACTCAAGCTGGGCTACCTTATCCCAGGGCAGCCCCTCCTATGGCTCCCCAGAGGACACAGATTCCTTCTGGAACCCTAACGCCTTCGAGACGGATTCCGACCTGCCGGCTGGATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCAACAGGGACCACCCAGTGGGAACCCCCCGGCCGGGCCTCCCCTCACAAGGGAGCAGCCCCCAAGAGGAGTCCCAGCTCACCTGGACAGGTTTTGCTCACGGAGAAGGCTTTGAGGATGGAGAGTTTTGGAAGGATGAACCAGTGATGAGGCCCCAATGGAGCTGGGACTGAAGGAACCTGAGGAGGGGACATTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCATTGCCCCAAGAGGAGGAGAAGCTACCCCCACGGAATACCAACCCAGGATAAAGTGTTTCGCCGTGCGATCCCTAGGCTGGGTAGAGATGACCGAGGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTGCATCCGTCAGCTCTCTTACCACAAAAACAACCTGCATGACCCCATGTCTGGGGGCTGGGGGGAAGGAAAGGATCTGCTACTACAGCTGGAGGACGAGACGCTAAAGCTAGTGGAGCCACAGAGCCAGGCACTGCTGCACGCCCAACCCATCATCAGCATCCGTGTGTGGGGCGTTGGGCGGGACAGTGGAAGGGACTTTGCCTACGTAGCTCGTGATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCCGCCAAGAACATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCCGAACGGCGTAATGCCCGCTGCTTGGTGAATGGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCCTTTCCAAGTGGAATTCCCAGCGCCTAAGAATGAGTTGGTCCAGAAGTTCCAAGTCTATTACCTGGGGAATGTACCTGTTGCTAAACCTGTTGGGGTAGATGTGATTAATGGGGCCCTCGAGTCAGTCCTGTCCTCCAGCAGCCGTGAGCAGTGGACCCCAAGTCATGTCAGTGTGGCTCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGGTGCGTTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCCACACATTTGCATTCATCATGGCTGCCGGCCCAGCCTCCTTCTGCTGCCACATGTTTTGGTGCGAGCCCAATGCTGCTAGCCTCTCAGAGGCTGTGCAGGCTGCGTGCATGCTTCGCTACCAGAAGTGTCTGGATGCCCGTTCCCAGGCCTCCACTTCCTGCCTCCCAGCACCCCTGCTGAGTCCGTGGCACGGCGTGTAGGGTGGACTGTCCGCAGGGGTGTTCAGTCGCTGTGGGGCTCCCTGAAGCCCAAACGGCTGGGGACCCATACCCCATGAAGAAGCCTCTGCCTTCCCTCCACCTGCTTGTGTCGGGCCCCAGGGAACTACAGGGTGTGGGTCAGGTAGGGGTCTAGAGGCTATTCCTAGGCCTTAGGCCTCCCAAAATATGCCCCTCCCCAGTAGCTAGGGTTCCCTGCCTAGGAGCTGGGGAGGGAGAGATCTAATCCCTTCAAGGAAGTCATAACACTGGTGTGGTAACAAGAGGAGCAGGAAGCAAGGCCAGCCCTGGCTCTCCATCCCCATGTGTTTCAGGTGGAACAGGAGGAACTGGCCCAGGCCAGGCCTCATACTCCTGGGACCCAGCAGGGGCAGGAGGAAGGGACTGGTCCAGGCATGGGTCCCTTCCCTTTGCCCGTGGGCACCTCTACTGTATTGATATCACTAATAAAGTCTGTCTGCACT 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-+&+$'-/,02-1111121...1/2//,/,021/$3')0/21533/,06*20(06226(241166664)1,*)+.%5/615645666656136511-44653/2%351446262451505-1-/3)146566456161*2.33346/53+)265/0785;3:5:2955/877/737477;857:080::9-8850/5887%64:::0139/4,587/2897108:79;4:5929559:95:2(674:/1,255-64/78523949'8242157769;:267268207177/7/54581:8949.65654/74518987984889314::9088:4326517:598*3.655032+144/3614'4383628145:85&-8-48737385::5955:,)5790:8;86;:8698:54'889:5073:;89:1:76&1.3:75-3939=/0:=>:==9=<>>;=51238;379>:<1=<9:6=<=84=3<8;3725297;<9>>:;<3;886;89.;3<9=<<2;7?<==0=289=:0?>95=:;9:=>->;9<=6>936=1<<2==>9>;<5997<97687<75<758:09::/82466;5/743979:>:=?>:;<*7/16;59:198;25;>9=1>>:=;1=:>9:<4;:::978468:81399:/=487'9;=4><9?'=<>84>;9/7876:<:79:?89=>9379?76;>;<99/:4=:>;9>56999855<<7<-=<;493977872669==?<826;:;79=9;:8<9;1<775::9<19>;2>>;>8>8?>>=?69/:;6-76529/9769=>?;=)9:29287>;969:69<3><=>?:>>:9:?71>;7;0337:3<149=8996-46;888981213%6+;5753975;;7>7773.47-52=>???;?993;=989'1/7::857>9==>:9=>5???=9:;38<9>1.221661957:88567:060>>>=865;4<7;=9?>>=9>=?69694=?;583?:96<>1<#;367:<:<6*<*6776771368::3975:6::?;:9=9<<::3780<840:;:;9=7=8;+>>><31=<9=>;?<88:-9;98598:;9?119:7%++5:==<>9/7;;>82*.,00475837895>/=8<>3%67989:366(488=9:679838:/6569,8377<=74774.46*4;9:9=5;5226:376?6>:7=2:;:2=:::=9915<<>:5.557;298>>>7=7646772::=7>56=53';=<8389=4:78;680:;6==6872/5<=<<;93<7;;<2><=6<=7>7=?=>9=8:=2<659:6;9999>972/767/2:?4:9869783<<7598=<>:9:0<79>5795:88<:1>;393:=;=;;9=8<=98:?7;3:862;:89;878;>99<;78>=0?;??>>.9;899<3;?>9<9=:>3<>:=?:>86=/889;<566244;89:;=<;<8=4??:>?>9<>>4<;:4<>=:?>?>8=<531;8>2;=4;>=>99=>=><>:8:>7<9<9:;=8=:63=4;=99>:=;;<9?17439;>3<;:<5978;==5=<>>>>8=>>7>><=9=:==.<=99==>=?<9<.8>?>??8=.;=<9<4;0:.8578671=:>?=9=6>?>0=:?<7>8:9?=>?8><=895697:0;?>5=;?9<>?=>=?;<5:66914316.4#/(/5301762675886/750:<0*745=;0:=>9<4;::=?>?6;::/7:=7=;:9;<;1=<8>11:>96479<:96458>;78998<7;9:964(7.4897>09?>9>67779:>;6:<>361?>993:792>4:2:7677639=889;&46,;=>>:=8<*4:;?7;;5-4232698199=5/8/-55/67964$4496+-3-28886:4;'479:19407.6/-7683/5/4127+466549684,3*97452-966553-37:6695529;89::6102::86+8696)126323756:/:6866/::658699:74;;7/6677154/83.1/7590992159&354:44&,().:98240/222'''&2/7;9635684563&8659762620/365688057106542463.39:44198598;55:;/988::5709868:;;9::.:::6561951:9'13998467;09:::9::;863/648:::0;4*7342499-32488/09:01219:564-4358;;866146656.12*8)70-.608195083:2.14%0-01/42)5554*/5416662501./,460621..651-6113046666.524669997:166.55/898;.65;865886:7::665682/393579;867:.5458:-543236;8;8:4::89;8*174290/:9915+.35897779:7:7974:;96;7957442:95%54619:,694076,,(63-65,'/45395,7953)(51.115,3400+.0/4/.*4655.46327928-63-660%&136)5/2-56167883341*754312-(566:7+879:596::355668 @rCer/493/507_50_CCS ATGGGCAATATTTTTTTCTTCCTTTGGGTACATAAAGCAATGACACATTTTACAATCAATGGTCTTGGTTTTGATAAAATACAGTTATTATTCCCAGATATTCCCTAATATTTACAAGTGAGGAAACTGAGGCACAAAAGACAGTTTAATTAACTTGCTGAAATTTACACATAAGAGCCAAGATCAGGGCCGGGCGTAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAGGAGTTCGAGACCAGCCTGGCCAACAAAGTGAAACCTTATCTCTACTAAAAGTACAAAAATTAGCCAGGCTGGTGGCACATGCCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGGGGTTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAATAACATC + KKKK=KKKKKKKKKKK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKK;KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKK7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK*KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKK @rCer/494/1497_54_CCS ATGGGGACTGCAACGCGGAGGAGCAGGATGGAGATCCCGGTGCCTGTGCAGCCGTCTTGGCTGCGCCGTGCCTCGGCCCCGTTGCCCGGACTTTCGGCGCCCGGACGCCTCTTTGACCAGCGCTTCGGCGAGGGGCTGCTGGAGGCCGAGCTGGCTGCGCTCTGCCCCACCACCCTCGCCCCCTACTACCTGCGCGCACCCAGCGTGGCGCTGCCCGTCGCCCAGGTGCCGACAGACCCCGGCACTTCTCGGTGCTGCTGGACGTGAAGCACTTCTCGCCGGAGGAATTGCTGTCAAGGTGGTGGGCGAACACGTGGAGGTGCACGCGCGCCACGAGGAACGCCCGGATGAGCACGGATTCGTCGCGCGCGAGTTCCACCGCCGCTACCGCCTGCCGCCTGGCGTGGATCCGGCTGCGGTGACGTCTGCGCTGTCCCCGAGGGCGTCCTGTCCATCCAGCCGCACCAGCGTCGACCCAGGCCCCACCGCCAGCCGCAGCCAAGTAGGGGGCTGGGCCGCGCCCGCACCCGGGAGCGTCCTCAGGCTCCCTCTATTGAAGCCGATCGACTCCGCCCAGCCAGATGTCCCGAGCGCGCCAAGAACTGTCCTCTCACCCACTCCTGGATTCTGCCCTGACCTCCACCCTGGACACTGCCTTGATAACTAGACCTTACACTGACACCCTCGCTCTCACACCTCTCCAGCTTTCGGACCCCACACCGACACCTCGCCGGCTTCCAGACCCTACCAGCACTACCCTAACCTCAGCCAACAGTCTCAGCCCCACCGACCCACTTTCTTGGCATATAGCCCACTTAAGACCCCTTCTCTACTTCCTTCTGAGTCCTCTACGAAGATATCTGTGGTACTACATTTCCATCCCTTCCCTATTTTGACACCAATTATGTGTAGACAGCCCTCCCCAACCCAGGCCTGTCAGCACAATCCCCCCACCTCCAAATGTCCTGGACTGCACAGACTTCCCACTCCAGACCATCCAGGCCTGGTTCCAAGACCTGATCCTCCCCTACGACCAGACAGTCCACAACTGCCCGCTCCAGCCCATTTTCTGCTGTGAAACCCAGCCAGCCACACAGACTCTGGAACCCTCTTCTGACCACCCTAATTCTTGGACACCTATCCAGCCAACCAGAACACCCAACCCCAAACTGTACAGACTCTCCCACCCAACCTCCCCAGACTCTGCACGAATGTCCTAGGCCCCCTCCCTAACTCTAACCAGACCCCGTCCCCCTAAGTCCCTTTGTCTTGACCCCCAAGTCTTCTTCAACCAGATAATCCTCGGCAACCCACCTCTCACCCCCTCCTCTCTTCTCCTTCAAGACCAGCTGAGCACCGGCTCTGATTCCCTACAGCCTTTCTCCCTGCCACCACTCCCTACTCTTCCCAGGCTCACTCTCCCAATAAATGTGCTAGAGCTCT + @866;)7079/<69??;831/4<7/13>CF;BFA7;<.@751;2?B50DADB:?>;>8:A=4+==?)@:A46B6AEE;E?B?CEDE88:9;13A82;9?9>>A>-?:<;84><=A9;@8A;C935+=2;?-<*47*>:=7>A;A9B:>CCBE;;?569(4<,.7;/BC@>CE?'24;3:@3167;:CC>FE0BA@=>@57=>>A?2FA>F@8B?=E3B<:>>95>;0B@3?98<1<>>A6<6:0681<><)=8&46-CF@E<9785?9A?6)11?EFE8B>?):8<<161%5<3C@D8DF,>E;E;>(4?7587?@?4><&;=268*+7(3?BC:79A;:?;>EC=1:9,;==B<5:;6?=<';;0=:@EE?3??@@=7.-10:?-<97=?7392@;DB59A@>G8;A<8?C31;;A:3D944=7=B>?57@>2=<;B>B@>49>.;?B;7;C3;854.-..43535$18908682883@(:;7;722666;*:9/3>8:7.5<9',%&4(,077?99'5/344+8,,165&//..102,%1641-*%2)34983,*+5&&1,$6/00441+-(.'),(1404*6052()#&3*.,(+461/.1,,03-($1.2-',.2021),'/22414.00-../34(1-3.-'%#+(*'%&--1/.0/31.(&021#,+.0#*),3.+*0-,#&-/5042/**/%2/-/0$)1()'-3+16)/..0/,,%(+.2)$)$%,14-)()63004051+/)+1//*,$%%,.4240),4,*.)(%&%-.&0,&...&,3++,+.*3.001$+/-+)$/'-*/)01'0+-3-(0-)/&*1(1..2/0+.,)((%*,10-02/.,53-551*024.4003-).+&*((,'40*-'),14.((+%*/-'2,0(0)+-35*3+.)/'/2'.3+302*3.2,*(.+'0).(.&1.-.35,-&,55656504*1/,0.1((01*'.0($1/3&/4112440.151+.0.3&/14,22*12.1166011*54/60.)+*-*'.'+))*+/3..+)0-%-'41*,+&$)-**0*'($'/,2.03+--()%1,./,(.&%+1433.56*+,-#--/42-44-1/651&/*23-(62,-56,44-24(-+/0&014-.3''*-+0*#'*(+,##0(,.),1-&/0+).0+,--.0*00-+%+0-/1/,,, @rCer/497/25_1523_CCS ATGGGGGGAGGATGCAGACGCCGCGGCCGGCGATGAGGATGGAGGCCGGGGAGGGAGCGCCGCCGGCGGGGGCGGGCGGCCGCGCCGCAGGCGGCTGGGGCAAGTGGGTGCGGCTCAACGTCGGGGGCACGGTGTTCCCTGACCACCCGGCAGACGTTGTGCCGCGAGCAGAAGTCCTTCCTCAGCCGCCTGTGCCAGGGGGGAAGAGCTGCAGTCGGACCGGGATGAGACCGGGGCCTACCTCATTGACCGTGACCCCACCTACTTCGGGCCCATCCTGAACTTCCTCCGGCATGGCAAGCTGGTGCTGGACAAGGACATGGCTGAGGAGGGGGTCCTGGAGGAAGCCGAGTTCTACAACATCGGCCCACTGATCCGCATCATCAAAGACCGGATGGAAGAGAAGGACTACACGGTGACCCAGGTCCCGCCTAAGCACGTGTACCGCGTGCTACAGTGCCAGGAGGAGGAGCTCACGCAGATGGTCTCCACCATGTCTGACGGCTGGCGCTTTGAGCAGCTGGTGAACATCGGCTCCTCCTACAACTACGGCAGCGAGGACCAGGCAGAGTTCCTGTGTGTGGTGTCCAAGGAGCTCCACAGCTCCCCGAATGGGCTGAGCTCAGAGTCCAGCCGCAAAACCAAGCTGTTACAAGCCAGAGGCACCCGGATGTGAGGCCCCAGATCACCTCCAGGGACTTGGGGTTCCCATCTGAAATCCTTTATTTTTGTACCATGGGTGGGCCCCGGGCCTGAGAAGGAAGAAGCTCCTCTGTCTGCACCTGTGGGGCTGTGACTCACCCCTGCCTCCAGGGCCGGGGCGGGGCGGGGGCCCCCGGGACCTCTCAAGGCCCAAGGTGGGCCCCAGGATCTCTGGGCAGAGCCGACTGCTCATGGCGGGACGTGTGGCAATGTCTGGCTGTGTGTCTCCAGCCCCGCGTCCCCTTTCCCGGGCTCCCCTGCTGCATGGCGGATGCACTCCTTCCTGGCCCAGTCACATCGCCTCCTTGAGCCTTAGTCCAGGGGGTAAACTCCTCCCACCCCACCTACCTCACAGGGTTGTTGTGAGGGTGCACAGAGGAGCAAGGTCCCTGAAGGCCCTCGGGCAGTATATAGGGGGCCGCCCACCTTCAGCTGCCCTGGGATGGGAAGGACCCAGCCCAACCCCTGGGCGTAACACTGTGTTTGCAAATGGAGATTCAGGTATTGGGGATGCAGGTTGTGGGGAGCTGGCCTGTCAGAGTAGGGGTAGGTGGCTTGGCCTTTACCTTGGTGATCCCATCCCCAGCCATTTGCATTGCTGGCCCAGCGCCTGGCCTGGGGGGCGGGGAGAGGCAGCAGAAGGGGCTGGGCAGGGGCGGTGGAGGACTCAGGAACTGCCCGGGGAGAGTGGGTGTGGCGGCTGAGCCAGCGGCCGTCCTGTGTTTGAATTCCTGGAATGGGTCCTTGCTTCTCGGCTATGTCGGACCCCACCGTGTAATAAAACCCGAAGGAACAG + 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@rCer/498/25_1767_CCS ATGGATGACCCAGCTTTTAGTGCTGGCTAGGTCTCTGGCCTGCTGCAGCTTCCATTTGCTCCTTATCTACCCTCTAGGCATCCAGTCTGGCTTAACCAGATTTCATGGCCTCATTTTGTCCTCTGCTACCGTGATTTCTACTCCTGAGGAGAAGCATAACTATCTTCTAGAGGGAAACATTTTCGCTTTGGTTATCAACCTTGGTTCTTTTGGGATATTGGAAATTACCCATTGAATGGACCCAGACTTACGGTGGAAGCTCCAGCACAATTAATGCTGAACGGGTTTGTTCTTTTTCTTCTGGCTTATAGTTGCATTATCCATTCTCATTACAGATGAAGAACTTCCAAATCTGTTTGTTACTTCTACCTCCCCCAGCCTGTTATTTTCAGGGTCACACTATGGAAGAACACTGTGGTGAAGGAAACACTCCGAATTCCTTGGGCAGGCATAGTCACTCATGTCTTTATTTCTGTCATGTTCATTTTGCAGTCCTGACACTGCTCTGTTGCTAGAGCTGCAACTATGTAGGTAGAAGTACTGTTGGCTTCGGGATACACACTGGCAACTCTATAGTACACTCTTATTTGATGTAACATAAGTATGTTTTTAAGAATTCATGTTATCCAAAATTATAAAAGCAGTTCTTTGAATGAGTGAAAGAAAGAGGGTTAAGGTTAGCTCCATACAAAGTCATATATAAGCAATGCAGCTTTTTAATTTAGCTTTTATTTAAGAGCAATGACCCTTTACCACTATCACTGGCAGTATACTAGCCTGCACCTTGTATTACTCTATTCCTCATCGTTTTGAAATATGTGCAACAACACTCAAAAGAGCTGTGCTACAAGAAACAATTTTCTTTCTGTAATGCCTTCCCTTTAGGATCACTAGAAGTCTGTACAATGCAGTTCAGATTCCCAAATTAATTGTCTTTCCTATTAGTGTTATCAAAACTCATAGCAGATTCCTGTATGTGCATGTATGTTATGAGTTGGATAAACGTTGGTGGACTTCATTTGGAGTGAATCAGAACGGGATTCCTGTGAGAAGCCAACATCCCTCTAAACAAACTTTTGGAGCATGACATGGCTTGGGTGTTTTCCCCCTCCAAATCTCATGTTGAAATGTGACCCCCAGTGTTGGAGGTGGGCCTAGTGGGAGTGTTTGGATCATGGGGTGGATCCTTGTGAATGTCTTGGTGCTATGCTTGTGGTAATGAATGAGTTCTCACTCTGAGTTCACGTGAGATATGGTTTCAAAGAACCTGGGGCCGGCTGTGGTGGCTTATGCCTGTAGTCTCAGCACTTTTGGAGGCCAAGAGTGGCGGATTACGAGGTCGGAGATGGAGACCATCCTGGCCAACATCTTGAAACCCCGTCTCTACTAAAATACAAAAATTTGCGGGTGTGGTGGCATGCATCTGTAGTCCCAGCTACTCAGGAGGCGGAGGCAGGAGAATTGCTTGAGCCGGGAGGCTGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAAACAAACAAAAAACCTGGCACCTCCTTCCTCTCTCTCTCTCTCTCTCGTTCTCTCACCATGTAACATGCTGGCTCCTCTCCTCCTGCATGATTGTAAACTTCCTGAGGCCCTCACCAGAAACAGATACCAGCATTATACTCCTTGTACAGTCTACAGAACCATCAGCCAAAATAAACCTCTTTTATTC 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@rCer/501/2038_57_CCS ATGGGGCTTTGGAGCGGACCTCGAGGCTCTGCGGCACACAGTCGGACCCAGTCGCCCAGGCACCGCCCGCGCCCCGCGGCCGCGACCGTCTCCTGCGCCGCCCAGAGGAGGGAGTTCCGAGCATCCCCCGCGGCGGCCACTCCTCGGGGCCAGGAGCGGGGAAGCGAAGTGCGAGAGACCCCGGACCCCAGCGCAGCCTCTTCCCGCCGCCCTAACCACCATGACCCACTTCAACAAGGCCCTTCCTACGGGCTCTCGGCCGAGGTCAAGAACAAGATTGCTTCCAAGTATGATCATCAAGCAGAAGAAGATCTTCGCAATTGGATAGAAGAGGTGACAGGCATGAGCATTGGCACCAACTTCCAGCTGGGCTTAAAGGATGGCATCATCCTCTGCGAACTTATAAACAAGCTACAGCCAGGCTCGGTGAAGAAGGTCAACGAGTCCTCACTGAACTGGCCTCAGTTGGAGAATATTGGCAACTTTATTAAAGCTATTCAGGCTTATGGTATGAAGCCACATGACATATTCGAAGCAAATGATCTTTTTGAGAATGGAAACATGACCCAGGTTCAGACTACTCTGGTGGCTCTAGCAGGTCTGGCTAAAACAAAAGGATTCCATACAACCATTGACATTGGAGTTAAGTATGCAGAAAAACAAACAAGACGTTTTGATGAAGGAAAATTAAAAGCTGGCCAAAGTGTAATTGGTCTGCAGATGGGAACCAACAAATGTGCCAGCCAGGCAGGTATGACAGCTTATGGGACTAGGAGGCACCTTTATGACCCCAAAATGCAAACTGACAAACCTTTTGACCAGACCACAATTAGTCTGCAGATGGGCACCAATAAAGGAGCCAGCCAGGCAGGGATGTTAGCACCAGGTACCAGAAGAGACATCTATGATCAGAAGCTAACATTACAGCCGGTGGACAACTCGACAATTTCCCTACAGATGGGTACCAACAAAGTTGCTTCCCAGAAAGGAATGAGTGTGTATGGGCTTGGGCGGCAAGTATATGATCCAAATACTGTGCTGCTCCTACAGAACCTGTCATTCACAACGGAAGCCAAGGAACAGGAACAAATGGTTCGGAAATCAGTGATAGTGATTATCAGGCAGAATACCCCGATGAGTATCATGGCGAGTACCAGGATGACTACCCAGAGATTACCAATATAGCGACCAAGGCATTGATTATTAGATCCACACAGAAGGAGCGCAGTATTTAGTCCATTGTTTTTATTCAGTGAGAACCAAGCTAGCCTTGAGTAATTTTTATCTTGTCTTCCTAAAACACTATTAAGCTTATTGTACTTTTAAGAAAAATTGCCTTACATACATTCCTTTTTCCTTTTTCTGCCTCTTCCCTCAATAGTTGCCTTTTAGTGCTGTAATAGTTAAATCCTACAGCATAATCAGTAACTCGCATATGAAGTAAAAAGGAATACTGTGAAAGGGGAGTACTCTTGTACAGCCAGTTCTTGTATGCAAAGATCTATGCATTTTTACAATCTTATATTAAACTGGTATTTTCAAACAATAGAAACTATTTTTTTTTTTTTTTTTTTACAGTTTAGTGTATCTGGTTTCTACATGGAAGACTAAACTCATGCTTATTGCTAAATGTGGTCTTTGCCAACTAAATTTAAGATGCAGCATTTTAGAAATTTACATATCAATGTTTCTACAGTATTGTTTGCTAATTTTTAAATAAAGTCATGATCAGTGTGCATTTGTGATTATATGTGTACTCATTCTCTTACCTAGCGGACAAGATCTTTTCAGAGTGGTGTTTCTAAAGGAGCATGTACAAAAGTGGCCTGTGGACATTTAGGCCTGGGTGATGCATTTGCTCTTCCTGTTTGTGCCAATGTATCAATGTAGAGTTGCTCTGTTTTCTTCAACTGTATTTATTGCTGCATTTCTCAGCATAAACTTATCCCATTGTATTTTTTATAAATAAATATTTTGTTTT 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rCer/503/25_2375_CCS ATGGGGAGCTGGGCCGGCGGAGCAGAGGTGCAGAAGCAACTGCGTCCAAGCTGTCTGGCAGCTTCAGGTGGACCCAGAAGACGTTCCCAACTCAGGGAGACTCAGCGATCACTCACTTGCTGTACAGAATGATATTCCTCACGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGTCACTGGGGTGCCTGGATGCCCTCCTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATCCCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCCGTGGTGCATGGCGTCTGGTACTTCAATAGCCCCTACCCAAGAACTACCCTCCGGTGGTCTTCAAGTCGCGCACCCAAGTGTACACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGCAACTGCACCCTCCTGCTCAGCAACGTCAGCCCGAGCTGGGCGGGAAGTACTATTTCCGTGGGGACCTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGCGTCCTGGACATCATCAACACCCCCACATCGTAGTGCCCCCAGAGGTGGTGGCAGGCACGGAAGTGGAGGTCAGCTGCATGGTGCCAGACAACTGCCCAGAGCTGCGTCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTGGGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCGCTGCTGCACTTCGTGCCCACGAGGGAGGCCAACGGCCACCGGCTGGGCTGCCAGGCCTCCTTCCCAACACCACCCTGCAGTTCGAAGGCTACGCCAGCCTGGACGTCAAGTACCCCCCGGTGATTGTGGAGATGAACTCCTCGGTGGAAGCCATCGAGGGCTCCCACGTGAGCCTGCTCTGTGGGGCTGACAGCAACCCGCCGCCGCTGCTGACCTGGATGCGGGACGGGACGGTGCTCCGGGAGGCCGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAGGACGGCGTCTACGCCTGCCTGGCCGAGAATGCCTACGGCCAGGACAACCGCACCGTGGGGCTCAGTGTCATGTATGCACCCTGGAAGCCGACGGTGAACGGGACCATGGTGGCCGTAGAGGGGAGACGGTCTCTATCTTGTGCTCTACGCAGAGCAACCCGGACCCTATTCTCACCATCTTCAAGGAGAAGCAGATCCTGGCTACAGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCGGCCGTGTCGCCCGAGGATGATGGAGAGTACTGGTGCGTGGCTGAGAACCAGTATGGCCAGAGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCTCCTGTGCTCCTCCTGGAGTCCCACTGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCATCCGTGGCCTTTGAGCTGCCGTCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTCGTGTACTCCGAGCGCAGCGGCCTGGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCCCAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAGCTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCTGTGGTCGCCTTTGCCATCCTGATTGCCATCGTCTGCTACATTACCCAGACACGCAGGAAAAGAACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAGCCCTGCCGTCCTGTTCAGCAGTGACTTCCGCATCTCGGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAGAGGAGGCTGCTGGGCCTTCGGGGAGAACCCCCAGAGCTGGACCTGAGCTATTCTCACTCGGACCTGGGGAAACGGCCCACCAAGGACAGCTACACACTGACGGAGGAGCTAGCTGAGTATGCTGAAATCCGGGTCAAGTGAAGGAGCTGGGGGCAGCCCATGTGGCTGACCCCCCTCAGGACCCTCGCTGGCCCCCACTGGCTGCGGGCTCCCTTCCTCCCAAAAGTAGCGGGGGCTGGGGCAGGAGGGGAATGAGGCAGGTGACAGTGAGGTCCTGGGGACCTGACCTCCCCCTCCTTCCCAGCTGCCCCTCCCTGCCAACACCCCCACGCCCTCATTACGGCTCCTCTCCAACCACCTTTACCCTCATCTGTCCGGAGAGGAGCTCTGTCTGTCCGTGTTATTTATTGCTACTTCCTGCCTGGTCTCCTGCCCCGACACCTGGCCCCAGGGCCTGTACAAAAGGGACATGAAATAAATGCCCCGAAG 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@rCer/504/1663_50_CCS ACATTACAACGCAGGTACTGGGGCTTGAGGACAGACCACGACTGACTGCCGAGTGCTGGTCTGAGCGCAGAGAGGAGCCGCGGCGGGCGACGGCGCGGGGGCGCGGGGGCGCCGAATCGGGCCCCAAGCGCGGGCCCGCGGGGGCTCCTCGCCAGCAGCTCGTGGCCAAGTCGCACAGCTTCTTCTCGCTGCTGAAGAAGAACGGCGCTCGGAAACGCAAGGGGGACCCCGACGCGAGCAAGGCCGGCGGCAAACAAACGGGGCTGCGGGGCTGTCAGCGCATGCGTGGCACCGGAAAGAAGCGCAAGCGAGGCGCGGAGGGGCGCGCGGCGGGGCGGCCTGATCTGCCGGCTGCTCACCGCCAGCTGGAGTGCGTCAAAGGAGGACGCCCAGAGCGCGCGACCGAGGAGCGCCAGGAGCCCGCGACCAGCAGCTGTGGAGATTTATGCAGACCAGAGAAGAGGCAGGTCCCGCTGTGACAAGCATGCCCCCGGCAGGCAAGCCGGCTCTTTACAAGAACCGGCGTGGGCTCCAGGGAGCGGGGAAAGATGGCCACCGACGAGGTGGACGACACTCCTGCAGGTTCTGGACATGCGTCCCAGACCGAGAGGCACCGGGCCCAGGAGGCGCGGCTAAGTGGCAGCTGCGCTGGAAGCAAGTGGCGCCGAAACCCCAAAGACACCAGGTGTGGGAGCGCCAAGGACGCGTCCCGTCAAGCGCGGAGGTCAACCGGATTCCATCGACCCATCCGAAGAGGACCAAGCCCCGAAAGAGCAGCAGGAAGCGTCCCCAACAGCGACGAGGCTACTGGGACTCCACACGCAGCCAGAGAGACAGCGCACAGCGGGAAAAGGCGGGCATCCCCCGATAGCTACGTGGGACGCGCTCTACATCTCTATGCACCGGACGGAATCCAGAACCTTCCTGGGGGAAGGACAACGAGAGACTCCTGCCTGTCCGTTAAGCCGTATTCCAGCACATCACTTGTCCGCGCGAACCCAGGCAGCTTGTTGAAGGACTTAAGTCCCTATTAGCATCAAGCATTGACAACCTTCATCTAGCCATCCGTGGTGCACCAGCAACCTCCAGGAGTGAGATGCCAGAACAAAATCCGGTTCAAAGTGCTGTCCGCAGAGTCAGAACGGGCTTGGCTGGGACACCATCAGGGCACGGCTTCCACGACAGTGCCAAAGTTGTGAGGTCTTCCAGCAAGTGATGGCCACATGCAAGAATACAATTTCCTGGAAACACTGCAGTTAGTTTGCTTTTCCTAAAGAAAGTCTTTCAGGACACACCGTCCGCTGCCAGAGCATGACCGAGAGTGTCTGTGCCTGAAGGACAGGATAACACGGAAAGAGGGATCTACACTTGGGTTCTCCTCTAAGATAAGTCCTGAGAGTTATTTTCAAGCACTTTTTCTTTTTACCTTTAATTTTCTTCTTTTTTCTTTAATATAGTGAACTTGGAAGTCACCTTACTTGCTTTGCAGAACAGGATAGCCAAACCTAATAAGAGCATGCTGATATTGGATAGCCAGTGTCGAGCCTGAAGGAACCACTGAGAACAGAGGAGATCTCTTCAACGATTTCCTTCCTTCTTTTCCTCTTTCCTTC 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@rCer/505/24_1884_CCS ATGGGGAGCGAAAAGCCGCCGGTGTTTCTCCACCTGGCTCTCCTCTATCTCCGGGCAGGCTCACCCGAGATCCCCCCCACACCGAACCCCCTCTGCACGCTCGGCCCAGCGCTGTTGCCCCGGGAGCGGACGTTTCTGTAGCTATTTGAGCACACCTTGACGTCGGCGGAGGGAGCTGGACAGGGCCAGCAGCGAAGGAGGCAGGCCCCGCGCGGGGAATCTCGGAAGCCCTGCGGTGCATCATGAAGTTCCAGTACAAGGAGGACCATCCCTTTGAGTATCGGAAAAAGGAAGGAGAAAAGATCCCGGAAGAAATATCCGGACAGGGTCCCCGTGATTGTAGAGAAGGCTCCAAAAGCCAGGGTGCCTGATCTGGACAAGAGGAAGTACCTAGTGCCCTCTGACCTTACCGTTGGCCAGTTCTACTTTCTTAATCCGGAAGAGAATCCACCTGAGACCTGAGGACGCCTTATTCTTCTTTGTCAACAACACTATCCCTCCCACCAGTGCTACCATGGGCCAACTGTATGAGGACAATCATGAGGAAGACTATTTTCTGTATGTGGCCTACAGTGATGAGAGTGTCTATGGGAAATGAGTGGTTGGAAAGCCCAGCAGATGGGAGCACCTGGACTTGGGGGTAGGGGAGGGGTGTGCGTGCGACTTGGGGAAAGAGGGTGACTCCCACCGCGAGGAGACAGAAGGTGAAGACAATCTAGAAACATTACACCGCACACACCGTCATCATATTTTCACATGCTCAATTGATATTTTTTGCTGCTTCCTCGGCCCAGGGAGAAAGCATGTCAGGACAGAGCTGTTTGGATTGGCTTTGGTAGAGGGATACGGATGATGTAATTTCACAAGCATTCCTGAGATTTAATTTTGTGCAGTTTCATAGAAGGGTCAGGAGGTGGACAAGTTGGGGCCAGAGATGATGGTAGTCCAGCAGCAACTCCCTGTGCTCCCTTCTCTTTGGGCAGCGATTCTATTTTGACATTTGCACAGGACAGGTAGGGAAAGGGGACTTGTGGTAGTGGACCATACTGGGGACCAAAAGAGACCACTGTAATTGATGCATTGTGGCCCTGTTCTTTCCTGTCTCACACTTCTTTTCTCCCATCCCAGCTGCAGTCTCACTCAAACATCACAGTACCACCCCAGGGGTGGCAGTAGACCACAACCCAGAAATTTAGACAGCGATCTCTTACCTTTGGAAAATAGGGGTTAGACATAAAGGTGGTTATGATTAAGAAGATTGTTTTGTTATTAAATAGCATTAAACTGGAATTGACAAGACTATTGAGCATCTCTGTCTAACCTGTTCTTTCTCTCTGGTGCCCCTTATCTCACCCCTACCTTGGAATTTAAGTCTCAGGCATTTCCAGTTGTAGACTAAAACCACTCTTAGCATCTCCTCTAGTATTTTCCATGTATCAGGACAGAGATGTCTTATGTAGGGAGGGAGCAAGTGTGAAGTAAGGTAATTATATACACCTCTCATTCAGGATTCTTGCTCCCATGCTGCTGTCCCTTCAGGCTCACACGCACAGGAATGCTATGTGATGGCCAGCTGCTTCCCTCCTTGGTTATCATCCACTGCAGCTGCTAGTTAGAAAGGTTTGGAGGGATGACTTTTTAGTAAATCATGGGGATTTTATTGATTTATTTTCACTTTTGGGGTTTTTGTGGGGTGGGAGTGGGGAGCAGGAATTGCACTCAGACATGACATTTCAATTCATCTCTGCTAATGAAAAGGGTCCTTCCTCTTGGGGGAAATCTTTGTGTCAGTTCTGTCAGCTGCAAGTTCTTGTATAATGAAGTCAATGCCATCAGGCCAAGGAAATAAAATAATTGCTT 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@rCer/525/1524_53_CCS CCTGCTCTCCTGCTCCTGCCGCTTCCTCCCGCAGCCGGGGACAGATAAGTCGAAGAATGGACGCAATGGTGGCGTGACGCACCATTACGATACGAGCCCTCACATTGATGGGAGGAGTACATCCCCTTCAAGCAGTACATTGGCAAATACGTCCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCATACATTGAACTGAATGCACACAAGAAGAGCTTGCACATTTGTCTGGTCCTCTCGGCTTTCCTGCAACCAATTGGAAAACAGGAACCAGGCGAGAACTCAGAGATCCTTCCAGCCTCAAGTATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTCCAGCTCTTGAGAAAGGGGATGTGAATGGAGAGAAAGAGCAGAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCGGAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTCCACGACATCCGCTGGAACTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCTGTCATGCGCCTGGCACCACGGACCACGATCAGCAATGTCAAGATGACATCCTATCCTACATGAGCGGCAGGCAGCCCTGGGGTCAAGAGGAAGTAACTGAAGGCTGTCTCATCCCATGTCCACCATGTAGGGAGGGACTTTGTTCAGGAAGAATCCGTGTCTCCAACCACACTATCTACCACCACAGACCCCTTCCTATCACTCAAGGCCCCAGCCTGGTACAAATGGATGCATACAGTTCTGTGTCTGTACTGCCAGGCATGTGAGTGTGGGTGCATGTGGGTGTTTACACACAGGCCTACAGTGTGCGTGACGTGTGTGTGTATGGGTGTACAGCCACGTGTCTACCTATGTGTCTTTCTGGGAATGTGTGCCATCTGTGTGCCTGCAGCTGTGTAATGCTGGAGAATAACCACCTTTCTCTCCAGTTCTCCATTCCAATGATGATAGTTCACTTACACCTAACCCAAAGGAAAAACCAGCTCGAGGTCCAATTGTTCTGCTGTATCGATACGCTCAACCTTGGGGCCAGCATCTCCCACTGCCTCCAAATATTAGTAACTACCACTGACGTCCCAGAAGTTTCTGGGTCTACCACACGCCCAATCCCCAACTCCTCCTTCCTGAAGGCCCTCCCAAGGTACATCCCCAGCCCACAGTTCCCCTGAGAGAGATCAACCTCCCTGAGATCAGCCAAGACAGATGTGAGAGCAAGGGCCACGTACCCCATGTCAGGGTGGCGTCTTCATGAGGAGGGCCCAAAGCCCTTGTGGGCGGACCTCCCCTGAGCCTTCTGAGGGGCCAGCTCTTAGTGCATTCAGGCTAAGGCCCCTGGGCAGGGATGCCACCCCTGCTGCTTCAGAGGATGTGCCCTCTCCCTCACTGGTCCATTGGCATGAGACTCACCCCCTGTCTGCCCAGTAAAAGCCTTTCTGCAGC + .)((,('%+(,,,(-'($&&$$($,'+-,'$%%'('*+,%,)%'++,(()*0-'$$#*%##"#$$#'')%$"/**("(*++0+$(*.,(#+*.##'+-).,+$14)53-.0%'6-001.32221/&)'.4'524-*/322+1'0260/00-32.$+0.0#)422.4,56340/224422969,3*44./11$51$%*.1-%.5/5232.003.&0,/-&0*$-'/+'+'%%&02,)+*+1('4+'(&03/10,#0%243/&/*51/%'(11-(,'0'3+/(0/(3-/+0)---31+0+3.'+&3$$-0(+.0')+++&.5.+)-)+-(+5,/4(431*52/.$(1/2*4-1./-*2%()+0+%(32&/10-*53.1--+.015+24(220+$224.,'--.5+2.+65/56/*$3')/12&)-1)32'.32$.3--3341/'1184,)055:644-,/25414=-8*76&758?670571:0-227.:1*088-?957'0-/<2/6+;11:/8<<7)=37333:40//-0'*02-2)22.2%1:0:98(1&-+46684;;-8(-2?;:70391:/,&&++/6'964=55196863'/+(588,37:882,;:6#76=8=9:26:9:?;7:2:1<236)15:8<789*<33695.4+%7;6489%+5?19109$27'974,=5&0142'676799:'7.=5574770,.-02#47483,.2780$7#0,66987.47;2?9>9;*1,5(59606484+54'73,2:1=7:>97:021,09+4244/44'2+'&43,000)'$$-2&)/,(+(/41+7376+616502,5-1(8;:9.-11762589%)194.4(/1052<7033.34605+99.+(+,-'6,11'04,5532*0)452=33+190,9/67760-751:539><90.'02-47/0.*8151707:59,6:13/'05656+.+;,,(8-289;;=871757+-45617414./-022-2&15-23+316277/556-38799:--303*9(*3,5794/64$78<555/$'33;11)6/966/936-1*(035937635<32>758077<112::6975=/8414000.96$5:=;546%3697(0,/09337+$/4;(=7+788#;.,0=/77%:3726=;3:.69/4,2&<55#4;329<>>-5+77'4637=.%/;,8(8&;46:;:7=3;4:8;*378600=;.<34'.5=9750*455.4739744#82<90249<=551/6;9;<(6?461652,6531'8&7:;)-:'68(5:9)4&:36;&8>3;>/1:992/=2:9717930:2=>:,9:<7:766-7877'+:66*471423<86=3482-)2;:66'27/9;%95;3-5323.20663<:97:504,004355)972:95<<2;5::75*;<0=;09==3+47 @rCer/526/28_1568_CCS GAGTAGCTCCCCGGACGCTGGAAGAATCTCTGCTACCAAACAGTGATAGAAAGGATTCTCTCCAAAGCCATCTGCTCTCAGGCTGCCGAGATTGGAGTTGTGACAAGAGATAGAGAAAGAGGACCTGGGTCTATGCCCAGCCTGGAGCTGTCGCCTGGGGAACCCATCCTCATTTCCTCCCAGCCTCCGCCAGAACCTGGGCGCTGAGTCCCCACCTTCTTCACTGATCTTCACCTGATCCGAGAGGTTTCGAACTCGGCTAGTTCCTAAGCAGGCGCAGGACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAGAGCCTGCCGCTGTCATGACCTTTGACCTCACCAAGATCACAAAGTATGGGGTTGACCTAGCCCTTGACCCAGTCCCCTGGCTCTGCCCATCTCCATCAGCTGTTCTCTTTTCCCTGTCTTCCTTTCCTTATCTGTGAACACCGTGTCCCCAAACCTCACTGGCTCTCAAAGGCACATGACATACACAATCTTTTCCTTCTGAGTCCTTCCAGAACCTCCTCCTCCTTTGAGGTTCGAACCTGGACCCAGAGGGAGGTGATTTTTTATGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTTCGGGACGGCAGGCCTGAGATCCAACTGCACAATTACTGGGCCCAGCTTACGGTGGTGCTGGACCACGACTGGATGACGGGAGATGGCACCAGGTGGAAGTCAAGATGGATGGGGACTCTGTGCTACTGAAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCTGACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGCTGTTCTTCCCCCGCTTCCAACCTTCGGTTGCCGCTAGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTGGACAAACAGGCCGAGATCTCAGCATCTGCCCCACTAGCCTCAAGAAGCTGTGATGTAGAATCAAATCCGGGATATTTCTCCCTCCAGGGACTCATGCAGAATTCAATCTCCAAGACATTCCCCAGCCTCATGCAGAGCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGTAGGCTCAGGCCACCTTCTTTCTCTTGGGACACCGGAGAACCCATCTTGGCTCAGTCTCCACCTCCAAGATCAAAAGGTGGTGCTGTCTTCTGGGTCGGGCCCAGGATGGATCTGCCCCTGGTCTTGGGACTCCCTCTTCAGCGAAGCTGAGTATGTCCAGGTGGTCTTGAGCCAAGGACAAAAGATGGAGGTCTTGCCCTCCTCCCTAGGCTTGGCTTCCCTCCTTAACCTCTGGCCAAGCCTCAAGGGCGTCTCTTCTCGGGGCTTTACCAGGAGAAGACTCGTCCACTCTTTTGCCTGGCAATGGCTTTGGGACAAGGTCAGAGGCTGGATGTGGGACCGGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGTCCCCAGAGCCCAGCAATGGCACTGACGCTTCCCATTAAAGCTCCACCTAAGAACCC + 1,,012(3+.///+2-4--16,3.23+0442234212(.01-/3./,15-01.+./0254200'121462/1440/-/23#5&,4).1/00-1*0+,/252450#0+11..00/+%*+.**,3141-43,.'&(,#.-.,+5553/4+221/-*(-()/1/3%/,/5&5/)1&.1#)$$43%.365*44020,&/&/106/(-52/)*/'134(-4+,10-3154.1/(*.0-*0.1/.154..4.&$1.(/+1()323+,,/-+)&,+1%.-&/-03,0620,//'+,53/40/62-+0//.)06-*1(0++104/%.30*.03(44-541.,35-4/3.:::6;)/1/2*51,7986429.70.+98946/0-33,4(848:58,/5223)7875.862+7:*960.943375520-44064*74:;7,7424.0.9(,164,62867::757-3&*//89:9-942'48#6/561-'694058/64+1,.)4989:34)4426655/397288;4623451:,63643/95:3/39-1336,76345601850:/63'7/%26492-776%0003*15585..%2-1060376676+.937156158/1*60312:9(5&(***/+5459965541,6:2)35495./4*/:4/08+2454*56.722++'*0..11&&010).///3015650).*2/+-*434.2-25*33//,*,.4-//102-.1044.*)051/4%3(+-*112..5+546,11+4)4250,6+,6,450.*-.).,1,0/-)../--+&+'%1+,.112.1-+0-&,+0*,)1/%,-+./1..*(0011+&-%+.//($-+2.-0(,0100+-,&/+1*+$,///(0/+)+,0++(%$*-0/2.-12-++1,0.1.11-.*-$//,(,+01/201-1-,+20,/-2).0(,-+).&(./-//..#+-/+-,-/(,'-$&&+10'%*,,*-)+,0+,*-+.0)&,##%)).,0./+#+*,+-,)0-/*&0-(),&-+-&*-.200*/.(00,1+/2(1.--1,1,/+*%*)(*%%.%)+1(++0//**/.&,+)10&+*0(&&*-(*,'(%%,,*,2++,.)-&+*.-',+('-(,&)0%*$))'*-)+,+*-+220/+*+02.1*+111*+,*)+-.2,,,$+,'100%(*%+&'%#'*)+.,''((((#($$*+"#+#%&%&',&+$(&()(,,($*'''%$$#(++)*.-),)#(*))&',))%+,-*-+$(&&%%,+))&&'+(+,.+#"&'%&)(())+-&$$##%)-*'*,%(##)')'(-,,,(*+,-''&*('+&**+%#)(-''''(&&'-(,)(+''%$&%$%"%++((&')+()'#%''(''(*(%(($'&#$''--))(-$#%(&,+'('&()')%#,)*$#&))+-&,,(('&+*)$*'($&),&+,,',*-,)-*("$&$$)()&()+(---,')+(%')*%$)+()&)*')($)+*.+$+*)**'((*-+'$)''%+*-)+*(+.+)---.-*-#&) @rCer/530/25_1035_CCS ATGGGGGAGCGCAGAGCGGTTTGGTCGTTCGTTGGGCTTGTGTCCGTTCTTAGCTCGGCGATTGCGGCTGTTCCTCGGGCAGCGGAAGCGGCGCGGCGGTCGGAGAAGTGGCTTAAAACTTCGGCGTTGGGTGAAAGAAAATGGCCCGAACCAAGCAGACTGCTCGTAAATCCACCGGTGGGAAAGCGCCCCGCAAACAGCTGGCCACAAAAGCCGCCAGGAAAAGCGCTCCCTCTACCGGCGGGGTGAAGAAGCCTCATCGTTACAGGCCCGGGACCGTGGCGCTTCGAGAGATTCGCCGTTATCAGAAGTCGACCGAGCTGCTCATTCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGCTCAGGATTTCAAAACCGACCTGAGGTTTCAGAGCGCGGCCATTGGTGCGCTGCAGGAGGCTAGTGAAGCATACCTGGTGGGTCTGTTCGAAGATACTAATCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATGCCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGCTTAAGTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAATTGTTTATAAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGACCTCAGTGATGTGAGCACTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATATTTCTTGCTTCTCATGATGCATGTTTCTGTATGTTAATGACTTGTTGGGTAGCTATTAAGGTACTAGAATTGATAAATGTGTACAGGGTCCTTTTGCAATAAAACTGGTTATGACTTGATCCAAGTGTTTAACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGAATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGTAACTTACAGTTT + >D,FGGJJJ?CDH>JFHJK@KEDJGJG;FFJKEFKJGIDDDHFFEEC6K8HBD/IKJFDKGKGJKHGIDKCAJJIKFJ9?KAJGIK.H?.JFD8G@6=EIDJGJHJCGIJFBKAJGHJFFJDJ@K>KI>HEC>KIJHBAI6KKHBJKJJDKIJHG@IKBJFH7F:@F3F:C??BFHIHKGGHJGEFHGJFBHJI0KJKFKGHHJGKGCK;EKJ=I=IJHH@H8EJ?KBKAEJHACEIG>KHCKIJGIBGFJC9>DG-HEIJF>JJDJIJ?IGJE=E=G?JHBKHFFHD?EIEKDIJKIBEBGFICCJJIJEBHJEJKJBG7KK?IIKJIGDKKKBJKIKIHKKAJCD>JGH7HE;8CAE=F79CHKFJIDCKKA>GFG;CKKKHDF=KKEK1KC?C,IIGJKJH0KKIHKJF?DKF>KKHKIFEGJK&IEFIEGEKGJK=KII=BH=KHJKJIJ>JEJHJHIKKB9F;B@CJADDBHGKJFGFJHKKGKJAHIGHKDJJFK=JJFFJJJIHKJHEJIDJEHJBGJDKJCKGJG4HAFIHCIJ8D;JHEJ9KI@IKKIKJJ9G@HG9AEGIHFI=KKG.KKKKF@KFJE-IK @rCer/540/25_1696_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTT + .<<8C?BCCB@ACGAAECA>8B4B;B;'47:;?DAB=>;9+EF?@ECA:?B;A>BA4D>>BBFD0E8D@;;C3=7<>B;9;==EC?:>>B?EDFDGCA@CBECACD3B>BCD7ACGEA@AA@>@4;?:B?@CEC@AAE<>=FB8A@?@?@7@.BCACE;D=@;BE==4:?5=?=<@:B70#-8?9G>FDE8E?BBCBDGFFAE8;E=?A<3A??=7<:B@DBB;C6@DCCAD9B:@@?8;@6.97CA8-CBFAC9;9=@;1:8B<0FFEFC=>?@=A8/>C@E7BDAFD;@DDB>82ADDECBE=@DBBBCCF?EB>?B>CC<=?@A?DGCB6F:EC=AAF:@EGDBBDB%?@CE><@E@C?E9CB@D<;DAGGCB@D=BF?C?@;@F6D?B@HFBFEDD=GF2.>@@A=>FEDGCA/EDG?AHE0GBCEC4A@7;ACCC?FECFHI?HHJ8FHHHH>>GGFAG9GDFDBIG>@CI@DIDGBAIEGD3GC?A8BFI@IG?BC6CIIHF:FJHIIHGBJGC1;4;;B>@E=IIIAD6A=EE>EIH;FG5E??D=HEBGFFE3JH?:IFIFDFC=HHDCCDC9HHHC6F?>HECDI@FGFB5GGHGCIGIFJEGHHCGH=IBIBHFIHF?;DGBIC=BEBFDHD>?C1GCDCCJEHIC4FHGFE9C2>ECD>ADCFDJFIB2EFCGBHD6FHCB@E?HEHEIAB>HEIDDAEB=B>A=:FGC@HDFFCCGD;=:>CHECCD>E>H9GB9FEB;5FIGB:>:DC=I9ADCEG=BC@AICGHC.B>?=AHDIAHGD4BHIGGEIH>HDFF@DCICF?HEGIEEEBIHCECECIC?@I=IHHH=GF7?BBGIHIAF@IFGIF?EF;GG:C+B<>BDCEFJ@HC?FFE9=>HJCE:JIGGH;HEFGAIGGCIIIFA-B)8DE>5DBB?B<@FDDDECC>F>;3ED:==A6IEFBDFEF-GE?BB:@A;:77?A:DEBE?FCA6>A:5@=><;E9@:6=:?@D?EC;?<@A<>E@EDFD8D+DB8DEFA@A<@>C-B@<.>?FB1:@ABBB?DB>FA;ADE9=BB>A=DG=:8D@F4?EAB;DE@<:5E=7EECCFDFDDE1B>FDG<7<@=>A?BCDA=@@B99315;D=CC9@AFFAGBC=C::CA;@E?CF>BBBFFDEF8AA@29C?B1ECC@CGGEC0@@5C;CDDEED;CE>751EEBE>>==BB?>?@>?>=D>@;>7DEFC>FE54ABEFGD@?D@FFB4D=CF@?CDD>@7B;@6F=@CBF?+@>AAEE?DCGD@@FFD?F=?DBCCB;@7?9ABA8E=:FFA4??FFAF?@ @rCer/543/1507_60_CCS ATGGGGGCGCGGAGCTGGAGTCCGGCTGGGCCGCAGCCGCTGGGAGGCCGGCGGTTGCCGTGGGGACCGGTCGGGCCCCTCCCTCCTCCGGTCTCCCGCCCCAGGTTCTTCCCCAGCGAGACGCGCCAGCGGACCGCGGGCGAGTGCAGCCGGTGACCCGGCGAGAGGCGGCGCCGCTCCCAAGATGTCGCAGACGGCCATGTCCGAAACCTACGATTTTTTGTTTAAGTTCTTGGTTATTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGTTCAAAGATAATAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGTTATTACCGAGGTGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCCCGAATGCTAGCGAGTCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTTGGAAACAAGTGCACTAACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCAAGAAAAATACTTAACAAAATTGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCGGGTATTCAGTACGGAGATGCTGCCTTGAGACAGCTGAGGTCACCCCGGCGCGCACAGGCCCGAATGCTCAGGAGTGTGGTTGTTAGGAGCCATGGGAGAGCGCACAGGTGTTCATACAGTGGCATTTGGGACACAATCGTTGGAACCTGAAGAACCTGAAGTTTTTTTACCACCATCCTTTTCTACTCTATATGGAAGTAGATCTTTATGGGGAAAAGAGAATTTGGGGTGTTCTGCAAGCTGGTCAAAGTGGCACAGCAAATCATATAAATCGAATTAAATGGACAACACCGTTAGATGTGTATGTAAAAATTTTCTGTTTCATATTTTCCCTTTCACTTTCGGTTTAAAACATGCTATAAACATGCTATAAACATGCTATGTACTGTATGTCCTGTAGCCCAGTGCGGCTCCGCAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGTTTCAGATTTTATTTTTTTTAATCATATGAACTAAAATTGTCAGTTGTGAGGTGTGCTCTTCTCATCATGTTGGTTATATTGCACAATTGGTTATATTTATGACCTGATATTCAAAGACTCTGGCATTGATAGCCAGTGTGTTTCTTATTTAATTCTGTTTACTACATTCTACATGGTGTTTACGTGATCCACACTTGAAATACTAGATCAGTAGACATTCACTAACAT + IIKKJB6KKKKIKIIJKCHHJKKKFKJJKFKCKHKEGCJAJKA4JKHKFKJKKJHEI>GEJJKK*JKEKKKJKI@KKKCKKKGKKJHKKKKIKKJKJIKKKDGKKKFKJIKKJKJKK@KJKKJGJKFKKHKKKIKEKKK0KIJFABFKKKJKKKK4K=GJK?KFKKKGK?JIKIHKKKKK8KKKDKCKKKKJ@KJKFKK5KGHK6KKFKKJKEKKKHHKKEKKKJJIKJKKK8KKKKKKKKDKKJIKKKKKKK/KKKKKHJKKKKJKKKJ(CKKE?KJ5>EKIHJKKKKHKK>KAKJJJKDKJKIHJF#GGK?KAJKCIKK>>JGKIKK@HKEJKKK8JJKKKJKKJKKKJGKHKJIJKKBKKJKJKKKKGJJKHIKIJGHKJKK7JKJJK=FKKGKHGK7K;KKK=KHKKKHKKKKKJKKKCKKKKKKJJKKCKKJKK9KEKKKK=KKKJKKHKKKKKKBKKKCH?KEKKAKIKDKKCKKKKKKKKIIKJKGK=KJH?;KHBKJKHKIKKCKJKKKKIKK-KKJJJGHKKKKIKKFHKAK?EKJJKK7HKKKKKJKIKKKJHIKKJKKKK?KIGBG=JHKJJKKKK,KFKK7KKHKDKKKKKK0KKKKK6IJK;HKKEBFJ>:JJKK@KK'KKIKKHCIKKKKIKKKKJKGKKHKK>DH@KKJKK?KKKK7JDJK9JKEJKD@JIKBKKKJKGKKJKJFCIGKJKK6KKKFK@JHK?IHIKKKK1KK7KKHKKKKK-KKGKI*KKK0BFKKF=@;JK9CDKGF>IFHK9HFKKKKKFJHKKKKIKGEEK4KKKJJKK)GKKKKKG7JKIKKKKKJIKKKKK;KKKKKKKKFIKKKKKKKKFKKKKGKHKKKKKJKKKKKKKKKKKHJBK @rCer/544/0_2170_CCS AACAAAAAGCAGAGAGATAAGGTAGAGGAGAGACACTAGGTAGGCAGTGAAATGCAGAGCGACAGTTAGTCAACAATGGTGGCCTGGCCGAGCACGCGAGGTGGTCCAGGAGCTCGGGGGCATTGCCGCGGAGCCTACGGGAGAGCTGCCAGAGTAGGGCATCCGTAGCGAGTGGCTCGCGTATGGCGGCGGTTCCCGAGTCGCTCTGCAGAACATCAATGCGATCCACCGCCCGACCGCTGCAGCATGCCTCGCCACCTTTGGCCATGCGAGCTCTAGCCCTCGGCCGTCAGGATGACGGCGGGTCAGGGGAGACGCATTGGGCTACTGGGAACAACGCCCACGAACCACTGAGGCTGCTTTCGTGCACTGGGACGCACGGAAGCGTGACGATGCGCTCAGCTCATCCCTGCTTCTACGTGAAGCTGCTCATCCAGGTGTGGTCAGAGCGATGCCCCGCTCACCCTGGGACCAAAAGTGCGGGGAGGAAGGTTCCTCTATCTGCTCAAGCTTCTCACCTACGACGCCAAGTACATGTGCAAGTGTGATAGGAAGATAGGGCTGTTCACGAGCCTGAGTCCCCGGCTGAATGTCCACGCCCTTTCCACTGTGACTCGGCGTAGCATGAGAAATGGTTTATCCCTCCAGATGAGATTGAAGCCAGGTTTTCCAAGCAAGGCATGAATGAAAGACTTCCCTGTAGAAAGTTGTGAAGGAGACTCCTACGTGATGAGATTGCAGTGTGGTGTTCCCGCATGTTGGCCACCCTCCTAGCATGTCATACTCATGCGCTGCATGGTCCAGTATTGTGGGACGGGAGGCCGAAGTAAACAGGGATGTGCTGCTGAGCTCCATTGGGAAATTCAAAAGAGGAGGCCCTGGGATCTTTGTTGGATATAATCCCTACCTCCTGAGGCGATGTAAATTTCTTGGAGGCTGTAACCTGCCTGCCACTTCATCAATGCCTACAGCTGGTGGATGACAGCGTGATGGACACCCCAGGGGGGGACTGGGATAATCGACCAGTTTATATCAGGTTCCCTTTAGTTCAGTACAGGCCCTGGCCATACCGGAGCTATACAAGTTTACGTGAATGGGGATGCAGTGAGCAATGCTGACTCTACCTATCGCTGCTAGTCGCGACCCTCGATAGGCTGTGAACAGCTGCGGGCTGCAAGGTGGGCTTACCCCTTACATTTCCCAGTGTTTCAAGATCCTGATTCACTGACTGGAGAAGTACCGTGAGGGCAGGCCCAGCCTCTTCCGAGGCTCCAGCTGCTTTCCGCCGTGGTATTCATCACGGAATCCATTGCTTTGCCCGGAGTAAAATCCTGAAATCATACTAAAAAACCATGGTCTAACCTGGCCACACCGTGGGTGAGGCCTGACTGACGCACCTTGGGACACCTGCAAGCGACGACTGACCAAACCAACAACAACCAGATGTTGCTACCAGCCAGCCGGGCTTCAGTTTTCCATATTTGCCAGTGTCTGTCCAGATGTGGGGATTGGTGGGGGATGGGGCTGTATCTGCCAGTGGATTTTGGGTCACCGTGGCAGACCTGGGGAAGATCTTAGAGCGAGGTGGGGAGTTTGGGAAGAATCTACCCATGAACCTCCCGATTTGCTGACGTCTGTCTTTGTGGCCAATGGGCCCCAGCGAGATTGGCTGTATGGGGGCCCAGGTTGGATGGGGGAATAGGCTATATGGGGTCAGAACCCCACTCCCTCTACCCTCCCGTCAGCCAGCGCTCCATACGCTGCCAGCTGCCTGGAGCATCATTCTCACCTGCGTTTGTACATAGGCGTAGATCTCCTCTGGCACAATGGCACCATCAATGTGCTAGGCCTATGCTAGGAGGCAAAAATGCAGGTCTCTGCCTGCGATTTTTCTCAACATCTACTTTTCTGATATGTAGGGCAAAAGCACCTGCCTTTCGAATGGCAGAAATCATTAGGACGCGACTGCGGAAATGTGTCCTCTCATCGAATGCTCACATCTGTTTAATGTGATGCCTCGCGTACAGGAATCTGGTTCCCCCTGTGCATGTTGTGAATACTCTCAGAGGTTTGGTCAGATCAGTGTCTGCCAAGTCCCACCAGTTTAAAGATTCAGGTAAAGATTGACCCCATCTCCCGCGCCAAATGAAATGATATTGGTGATTTTCGT + #$"""""#*"(*(*&**+%"##%"""$%$&#&(%&$'+'$+*)#+&)))$#($++''('#*'*,,",(+(%&)+#(+*+,)%%-,,(+#+$%&(%'$')**+%(+',',)**''+$($%$%&%&(#$)&)'()%*$()'')**,-.'+$('+'+*$&$'&+($),)()((&&'#%%('$)(()&&(),(-++*,$&,**(,'*#,++*%$*"*))*'#+'*-,(-).-',*&%"'%"'(,.+-*..&,.%.+'(*.%*.'"*-++/$.-/*$....",+(%-..,(*')"...#..('&-+(*,*#.',))+#%'.-/"#-++(-.".,+%,#).,&#-+#%$-)#,%-#&&-./+.*#.**+/,,-..'*)+,".)."%*)%$-..//-/-""-.,.../.',.).(%)').,".-//,."*///*-..*/&&-.-..+#,''-*..,/./.*)#&,'%(-)(#.'&*,.+/+*$/..-/)),,..-*/-+-"(.*("--#,-.".)/..-..//.*.(-.,(%%*,$-.-..,.+../*.+&*#..-#-)*.-,).*('.-.+,&#)-.)&...&.)&$+.,(''.&$+..*'&&-'),-%*)--+.'.-.&..,,#.-..///.-/$'-#&&&*+#.''-'%)-///..+/-./$,-%*'&''#*&.%'*#.)-%*$//.*)/-('-.-.-.()./.".-,)*-%,-./*,.,*.&&.)*....$../../+."..//.//&...,-(+$-.&--'$''$(,&'*&%-.#-./////./&-++&',.-'-,'.)+(-*//)."+*--&%%./,++..)*.")(+.(%#-.*+("..*...*//-/%.-+.,****-%%($)-*&$-,.,&.**&),*'*-.'."&+),)-('-%.*)-))-',(#'','&-.+/./.(-&##&&.,,+++".*.)'.)),&.-%..-%)#&*-.&-&(-#,)-#*##&*-,-.'&+,,%'-*.-.-(&*''-.)(*&,+(&(',,"..**)-"''#%,'*.-,($)'%%'%'(*(&(#+##%(.,&/-+.#)-,+(*(.-+*.,.#&.&+.-,&(")%',(+$&$.&./$-.&'*)%'&-.+/-../(#$..-...%.&-%-.&,-#///$'....)%..),,.."/.#/,///).)/&.%/.,',+*...))...++-*),-$%'(--.--",%"#)'-,&',&+.')"-.)+-&.&)&../."(/*+')(,%(.&/%-..,(&-.*+$-'./*.-.--'.-..$..&/./-/..,(/+-.,/.%--'"%-.+.,&#$+)"&+$.-&'.%&--*-#.+.-*)%*&"),-'#-%-.//"-'+,+''+(.//-+/./%.+--.&%.$..,/..,-./..+'*'.-.''.--#,,(()',(,-..%.-./*/*$.(-*-.+#"+.*).&/$./*..*.(.-'&&.+'.-."+---'&&.+.,')#,&/./.$&-*-/../,+.+/+//&//&/--'%'&-*.)),,'-&++#)'),&..+)*+..'..",#$&,*&.--/"++-,*&...*.$'.+////+//,(+(*//./".)..".......+$,+--"$*)(+''/*//.#"(,../"'#)..&*...)(%.//..#.////.'",.--.%-','#)*%#%',-""-'...$.,..$..(*((,)(,....-,)((+*)(+,+-$&'+,.%"+.)#'%.../)%))).'*"((+..--$+(.)-"./.,.-&-...-#++/."/#(/.".,/.&%(,,--..-./.----..%%&../"-+....//..(&///#.///('-$..-,.*.$..,.&.,.///%/+,/#-..(,*/.///&...,--')++#(..-&'..#.,///*/*&&/*-,+%.-/.%&*.".../.,)././/+./.".++'.$($../.'-/.**%#.+.("-.&&$*'($&,#(($"%#&-+#.-/#&-),$.../..(,+'/)-"/-).-/)/.../"#..-+#***++--%&*/././.-./.++$.#&.+,))&#%)...-''/"/--.'.*/..,#,".-.../(*,**#.)/-.///.//-/"+-#./.(-''(%..,*/-*..",.$)$--*%"//.-./-'&/.-,"&$-#*(+$#%./"+)///#/"--+-/./%(,&#-, @rCer/546/1619_61_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAAC + EFHGD*J>F6AECFBGGB;DGE?HFAE9=>EBF3C1KE=EI:JH5JBJBGHGCFIGHKI@C:EHII?IIECIHJKGFICB9JH>=GDII9GEEJ;EFIKI;I:GHEHBJHK6KBG?KJKJEEGJJJFCJHIBHFJJJJHHIF-;HEGD>DFEGI08IKD:FJKCIFIKCD?=E=CEC:>HHFEFF+KKJIHHJC3BIGIJGIFE>JHJCCIBDCCAAGI@IEICIJ7FFICDBD=GIBF>HC)FKCAHHF>>JGGD@A?E;E?JGJJJFF@>;F=3DHFK@GHIHDJGKF7A:AJCH;JC=IKKKJ&JJEKKJ@FIJBJFK>JK@@GGDIAHG?BEGDEGIHGFFC@:I6GJAHJGI4FGKHKKJKGACIJDKHIG4GKIGEH@F:KBC>GKEKI9FDIB@@AC:=G@AFDEH;DEEFDFEB3DHHGEIG@CHFHJDIEG>D5HF3JAHABBBB;;2@DIHIAJIJGAFCDC;GG6IJEAC411?-=C7DA?B*FDEFF@HB1EC=?C?=EHE;>:=;;A@ACEEAC>6C:GEF@C?4AED>DA;D5FDD=EC8FFFC;F>CEHFHFA@?;CBFFFB6779?F>GG'@@ED?>>4=E97?A?B5B<=6?CCH@F?ID:EJHCAII:IIFEFEGD1IIFAEBHHGF.DGE>D?5E?CAFG253DF@IGFEH?AED@5E?9HBDIDC=>5889IC@=?9+@:>E>?GG:E<@AEB=<@1IDD>59C6AA8?2GEE@GAEH/JFGG=CFEC?:;E9:C5:AFGIACHG>9F:88A$<(>E??GBEFA<4A=0<89C6FDDA@?HFG?AEHJH>BHIDGFBC@BBI??A@@9JCFBDF4G<<@99@9EBCGC6@59:87:.>@G>D=@@ADD<=<<=9>9/55246@DEACFA>DFEDEE3@=DAAA;B=2:@27>=ABEC?EB8;:,F99AB=B@36:??;@C9==295==<=:>=3?=BD?@5;=/73;54:8//3;:=0@>5;AC?>973>;;B5=ACFAB=B??:DFEG:::@B=@;?:5=E4D=:529<=@B1E=@EEE?+?=<><58;GAGDEE@;:?A=04 @rCer/549/0_1112_CCS CCAGATCGACTACCCTGAGATCGCCGAGGGCATCATGCCACGCCACCGCTTCATGTCTGCGTACGAGCAGAGGATTGAGCCTCCGGACCGGCGCTGGCAGTACCTGCTCATGCCGCTGAGCCCTATGAGACCATCGCCTTCAAGGTGCCGAGCAGAGAGATTGACAAGGCGGAGGGCAAGTTCTGGACACACTGGAACCGGGAGACCAAGCAGTTCTTCCTCCAGTTCCACTTTAAGATGGAGAAGCCCCCGGCTCCGCCCAGCCTCCCCGCCGGCCCCCTGGGGTGAAGCGGCCTCCACCTCCGCTGATGAATGGTCTGCCCCTCGGCCACCGCTGCCCGAGTCTTTGCCACCGCCACCGCCGGGAGGCCTACCTCTGCCACCCATGCCCCCCGCGGGGCCTGCACCCTCAGGGCCCCGGGACCACCCCAGCTACCCCCGCCAGCTCCAGGGGTCCACCCCCGGCCCCAGTGGTGCATCCCCCACCTCTGGCGTCCATCCCCCAGCTCCTGGGGTCCATCCCCCAGCTCCTGGCGTCCATCCCCCAGCCCCTGGGGTCCACCCACCAACCTCTGGGGTCCACCCCCCGGCTCCCGGAGTCCACCCTCCAGCCCCCGGGGTTCACCCTCCAGCCCCCGGGGTTCACCCACCAGCCCCTGGAGTCCACCCACCAGCCCCTGGGTTCACCCACCAGCCCCGGGGGTCCATCCTCCCCCATCAGCGGGGGTTCACCCCCAGGCCCCAGGGGTACACCCAGCAGCCCCTGCTGTTCACCCTCAGGCCCGGGGGTGCACCCACCAGCCCCAGGGATGCACCCTCAGGCCCCAGGAGTCCACCCCAACCTCCCGGGGTCCATCCATCAGCTCCTGGGGTCCACCCTCAGCCTCCTGGAGTTCACCCCTCAAATCCTGGGTACACCCCCCAACTCCCATGCCCCCAATGCTGAGGCCCCCACTCCCCTCCGAAGGCCCAGGGAACATACCTCCCCCTCCCCCAACCAACTGAGAAGCTGCTCCCTCCCCCAGCAAGCTCAGCGCCAGGTGCTCCTGCCTTTTGCCATTGAGAGAAGGCTGCTCTTTTGTACCGCCCCCTGCTCATTAAACAGCCTTCCC + S*-,0,.-).+04:9;AB?CACA@B8<+?B@D@9C>BBGHGF8EF:E=?GC;$8A@DBCD@?HIB6A;@=;FE:CC;0?;:AFDCEAB=BFHD@:EDDEHGGH>BCCCFB4AFA9II>HIHFG;E4A1BAGE:E7AC;B8EII=HB?B>,>=;=562:97<9;:96.78*9@>7;@;:%<<=;9-C<36/-4>?8=7A61>74@26C69;@BC>C6==6>?DCBG>8A?A?EDD=B76D=5:7593?A9@=40=5ADG9ICC>A;GD8>BFD<:CC,D=>6IIC>J1,=DG;?E??,=<=658;6;;;=?:/@ADA6=3#:6;@8?5=?A5B@<=@@DDD'FFFFC/@GBD?IHHCFJIB.BFGCEBB@=GE7CFIA>EE;-G<0DJGIE3-DFFF4JHHC:A>?EIHFIAGHIICG>FHH<4HC;JJHJJGJ@E%AE@GEF?EJD2EHE@IGF'FGHF0IIIFGHI:>EECIFF'CDGD7EJI>HGG5ACGEGGI6JJGGFDCA@6DB*C?9=EFF:HIG@$?<;BFBFA@GDDFA4GGH0EGFIIDABG?B4(=;BB@@BGD@1BCGDHIA9%>@BA:@H(EEBB:GFG>?AA6FGEIGE;?EID>DF>>,659??IFC?51(DD3DBBC>=CG>DFBEIFE?JFHB0JGF?@GC.@E?@A>D*FCFHBGCFGGGE'CCDAG:GH*IJ(DCGG?JDFHFIDAFIIE3HE6CEJH?HG'ADB@HH;KJDKBAJ>FAGFE-EGFDGIIJHIJKBIBJHKKCJA?JJIHIE,JJHGDHB;?:@E=HHCBD>GCH)@B @rCer/550/23_1593_CCS ATGGGAGGGCACAAGAGTTGAGGAATGGGTGAGTTTGGTGTCAGAGTGCCTTGTGGTTGGAGGGTGGACTCTTGTGATGCTTTGGGTATGAAATTGGCCCTCTTTTAGCATAAGTCGGGGAGTGTGCACTGGCTGGAGGCTTCCGGAGGCTTCCAGCCATGAGGTGTGAGCTGAAACCAATTTTTCCTCTTTCCTTATAGCATGTTGAGAAAATCTGTTGGGTTTTCAGCAGTCAGGGAAGGCCGGAGTTCTGCTTTAATCTGGGTAACTGAGGCTAATGTGAGCAAGACTTTGGTTAATTAACTGGGTTCTCAGATGCCACAGACTCCGTGAGAAGTCACCATTATTTTCAATGGTTGTGATAGAATTTCCCCCTAGTAGCCATTATTTTAAGATTATATTGCAGAGTTGCTTTATTTTGAGCTTTTCGTGTATACACAATCCCAAACTGGAAGAAATTTTACAAAAAGGAATCCTGCTGTGAAAGGTATATATTACTCTAGATTTTTCTTACTGTAAATATTGTAAGATTGTAATACTGTCAATATTTTATTAACCAACAAATGTTAATCTATGTGAAATCAGACTTATTTTAAATGTGCTTCTTATTTACTGTGTGTGGTCCCTGTTGCTGACAGTATTAAGTTATATTCTGATGTAAGATTAACTTTATTAAAGAATGTAAACATTAATGTTTCCTTATGGGAAAACAAATAAAGTATAAAGAAGACAATTCTTTTCATTGAAATATACTGTGTATTTACACTTGCTAGACCCAGCACCACTTATAAATTTAGTACACTGTTCAGAATTTTAGTTAACACAGCTGACATGGTTGTGCTCTGTTTGAAAGTCTAAGAATAGGTATTGTTTGGAATATACAGTTTGTATTTGTCTGCTGTGAATCATAATCTTGAAATTTCTAATCAAGTTTGTAAAATTTTTATAGTGAAACATTTTAATGACAATTTAAAAATTTATCTTCTCTAAAGAATGGTCAAAACAATATCCTTTCAGAAATAGAATTGTTCTTTAATATCTTTCCAAAATGACTTTGGTTAAATGGACCAGATGTATATTAGTTAAAATTTAGGACTAAGTTGTTGATATTCTTTGAGTTTACAAGTTAATCCTTATTGGAGATGTGCCAATATACAGTTAGAATATCATTAATTTGCACTGTTTGGGGACCCCATTTAAGAATGCTGAATTTTGCCAACTAAGAAGTAAGCAAATGCAATTTAAAAAGTAAATTTGAGCATTCTGTATTAAATATGTGCAGTTATTATCACATGAAGAAACGCAGTGTGTCGGGCTGTAATATTACCATATTTGCTGTCATGTTCTCCCATCTAAGTGCTGGGAATTCACCATGTGGAAACCAAGCAAACGTGTTGTGCATCAGCCGGCTTGAGTTTGTTCAATATCAAAGCTGAAAACTAGCGAGGTCTGCTGTACTGCTTATTGAAGTATTGTGATTATTTTAGGCATTGATTCTTACAAAATATATACTGTAACAGTATACTTTGTACAGATTTAAATTTTATTTGAAAAAATGAAATAAAGTAGG + KK7KIHHKKKJJIKJIKCKKAKK0JKBKHJJKK?KKAGEKKKJKKKKKI?:IFFKG>K?KIHKKKFKKJKK8KJKJIHEH??G8GIKKKK=KKJKJKJKKBE7JKKFFKCJKKJIFFKKKHKKKIJKKKIJKKKIKJJKKKKKKJKJHKJGKGKKKKKKKKIHIJJ;JKKKIK)JKFIIK9KKKKDKHJBEKIKH9FJGHJEHKGKJH1,@HJKKGJCKIKKDKKKJ;HKJHKKKEFKKKKKKJKDJIIBKKKGCKIKKKCJ@@EKKKKKBK?IHIIKJI@IFIJIKIKKKKBKKH6KKKKCIKFKKEKKKKKKJKJIHKKJJJKHKKHKIKKKKKIKKIHKKKGK;JKEHKHKIFKKKKJHKKKJK9KKKKKKEKDJKKKKKKKBKKKKKKJKKK.KKGKKKKJEKK5KKKKDKKJKKKKKHI@CFJGKKKKIJKKKDKKKKKHKHFKKKKKKKJEKKKK5KKHI6KKKKKGKKKHKHAKKFJII>KKIKKJEJHKKBKKDFKKKGKKKKKKK>JHKKKKKK'IKHKHKJKKAJFJBKKJJJJKKKKGJKGGFIKJK0KKKHKJKEKKKKIKJKKKJKKJKJKHB@IJJIIKKKEKJJKJKKKJFKGKKKKK=KKKKKGJKJJJ;KKJKCKKKKKKKJJKHKKKKJKKKKJKJJKGJDCJJ9HJKKH5CJBH<JJKJDKKJKKEKKKJIJ=K7KKKKJKJKKK:KJ@KKEIKJJJKJKKKFKGKK5KKKKKHCKK;KKKKKJKKKIDKFJJKHKKKHGHJHKKGHKKCJIKKKIKJJ>KKJKKJK?JIFJFKJJEKKJJKEAKKKBKHIKIJJ:KJEKKKFKKKKFKJJ@JKJKKKKKKJKKJHJKDKFKKJ;KEEK7>KHJKKKCKHK@KKKKKIBKKKJJKI?KHJKKKKBKKIJKHK>KKKKJKIKEKKKIKKIKIK5KKJHKJKKHADKJJKGKKJKJHKEKKKHJKKJIIKKKKKIKKKKCKKKGKKKKKKKDKKKKKJJEFIK @rCer/552/3326_60_CCS ATGGGGAGAGCATGCCGGGAGCTCGTGTCCAGACCGCTCGCCTCTGTTTGGACCCGATTTCGGTTCCTTCTGGGGTGTTAATGCTCCTGAAGTCCAATCGCACGTGTGCAGACCCCAGCCTGTACGACGCTGACTCCGCCCGGTCCCAGAACCAAAGCCATGCTGGGGTGTGGCCTCTGACCCAACGCGGAGAGGACCTCGCTTTGCGGGACCCCACCTGGAACCCGACCTCCCGGCCTCGCAGTCGATCGGAGCCGCCATGCATGGGAAGTTGCTGCCGCTGGCCGGCCTCTACCTGGTGCAGGGCCTGCCCTACGGGCTCCAGTCCGGCCTCCTGCCCGTGCTGCTGCGCGCCGGCGGCCTCTCCCTGACGCGCGTGGGGACTGGCCAAGGTTCTCTACACTCCGTGGCTGCTCAAGCTGGCGTGGCCCCCGCTGGTGGACGCGCAGGGCTCGGTGAGCAGGGCGCCAGCAGCCTGTTTCCTCTTCTCCTGCTGGACCAGGTGTTCTGCCCCTGAGCTGGGACTGTGGAATGGTGTGGGTGCTGTGGTCTGCTCCATCGCTGGCTCCTCCCTGGGTGGGACCTTGCTGGCCAAGCACTGGGAACTGCTGCCTCTGTTGAGGTCAGTGCTGCGGCTCCGCTTCGGGGGCCTAGCCTGCCAGACTGCCTTGGTCCTTCCACCTGGACACCCTGGGGGCCAGCATGGGCCCTGGCACAATCTTGAGAGGGTCAGCCTTGCTGAGCCTATGTCTGCAGCACTTCTTGGGAGGGCCTGGTCACCACAGTCACCTTTCACTGGGATTGATGCGTTGCAGCCAGCTGGCCCCCAGGGCCCTGCAGGCCAAACACTACAGCCTTCTGGCCACTCTGGAACTACTGGGGAAGCTGCTGCTGGCGCGCTCTGGCTGGAGGCCTGGCCGACGGGCTGGGGCCACATCCCTGCTTCTTCCTCCTGCTCATCCTCTCTGCCTTGCCCGTTCTGTACCTGGGCCTGGCACCCAGCACCTTTCTCTGAGCTGGGTGGCTGGACTGGTCAATAAAGCCACGTGTGCCTAGAATATGTGATGCGCTTGTCCCCAGGTTGTGGGGGCTGCCTCATTGGCCAGGAGGGCCCATAAAAACAATGTGAGCACTTTATATTCTGCATTTTGGAGTCTCCTCGTCCTCACACCCGGTAACAGGTTTTGCCCAGGGCCTCAGTCACTGCCCTAGCTGCTGACAACCCCAGCTCTACCCAACATCCCCCAACGCAGTGCAATCAGCAGGCCACCCGCAGGAGCTCTTCTGTGGCCAGGCGCACCAGGGCGTGGAAGCTCAGATTCAGCCTCAGGGACAGAAACTGGCGGATGTCGCAGCGGACCTGGTCCTCCCATCCTGGAGCTGTGTGGACAGGCACATCAGGCTTGCTCTGAGCTACCGTGGCACTGCATCCACACAGCAAGCCCCATGCAGCCCAAGGAACGTGCAACCCTGATGAGCTTCCTGGCCTTACTGTACTCACTCTGGCCTGCCCTGGCTCAGGGCCCTGCGTTGTCCTCCATGTCTCCCGGCCCCTGTGCTTCCTCTTCCACTTCCTCAAAGTAGCGGCCGAGCAGGTCCTTGAGCCTGGTGCTGCGCTCCTCATCCTGCTGCTCCAGGCAGGGCCCACAGCTGGGGAAGGCTATGCTGTGGGGAGGAGCCCGTCAGAGCTGATCACTGCAGGAGGGTGGATGGTCCCAGGCCCTGCCCGCCTCCTCCCAACCTGTGAAAGGCCTGAAAGGTTCTGCGCAGACGGGCCAGGGCCTGGCGCTCCCGGGCCCGCACACGGCCATAGAGGAAGTCACAGATCTGGTCCTTCTCCTCAGCGGTCAGGTCTCCTGGGCTGCGAAGGTGGAAGGCCAGCTCCCTGAACTCCACAAGCACCCCTGTCCTGTGCCGCACACCTGCCGGAAAGCATGTCAGATGCAGGCAGGCAGCATCCAGGGCTGGGTGGGGTGGGGCGGGGCGCACCTGTCCTGGTTCATGGTCCCACTGCAGCTGGCAGAGAGCCCGCCGTACGGAGGCCAGCTCCCAGCCCATGGAGTCCACCAGCTTGACCATATCAAACTCCACAGAGCTGCTGCCTTGCCTGGGTCCTTCAGGCAGCCGCTGGGCCAAGCACACAGCCAAGGGGGACACCTGTGCCCAAGGAAAAGGAAACATGTGGCCAGCAGCCCTGATTCTCCAACCTTGTCTCCAACTCAGGGCAGGGCGTGCTCACCTGTGGGCCAGGGCCTGGAGCTGGGCAGGGCCCCCAGGGCAGCTCAGACGGCAATGGATATAGGTGGTTGCCAGCAGCTCCAGCCAGTGGCGTGGGTGCAGCTCCAGGTAGCACAGCAAAAGTCTCGATGGCTGTGGGCAGAGCAGGGCTCAGGGGATGTGGGCACAGCCCATCCACACCCATGGCTTACCCCCAGGTTCCTCACCCTCCTCTGGCATGTCCAGAGCCTGCACGGTAAGCTGTACTGGGAGTGCCCGCTCATGGCCCACACAAGTCCTTCTGGGTCCTAGGGCTGCCTGGTGGACACCAAGCTGCTCAGCCTCTTGAGAGGAATACTTGGGCACAGGTTTTTTCTCCACCCATGGTCCCTTCCTGCTCTGGGGACGGCCTGGTGCAGGTGCAGGCTGGGAACACGCGCTGCACCAGCCTCTTCACGGCCAGGAAGTCTGTGCCGTTGGCGTGCACATGTCTGCGGAGCTCTCGCAGGTCTTCGCCCTGCGGGACGACTATCATGAGGGTGGGGTGGGGCACTGGGGGCTTGAGCACTGGCAGTTGGGGGGGTGCCAACCTGGGGCTGCAGGAAGAGGTGGCAGTGGGCAGGCTGCCCATCACGCCCGGCCCGGCCCACAGCCTGCACGTAGCTCTCGAAGCTTGGGGGCAGCCCCAGATGCAGCACAGCCCGCACATCTGGCCGGTCCAGCCCCATCCCGAAGGCCACCGTGGCCACAACCACCCGCAACTGGCCCTGCATGAAGGCCCCGCTGTACCCGCTGCCGTTCCCGGCCGCACATGCCCGCGTGGTAGGCCTCGGCCGTGGTTTTGGGGGCACGACCTTTGGGGAAGACAGGCAGATAATCAGTGGGAGGGCCATGTGTGCCCAAGGTGGGTTCACCAGGACCCCAGCCCTGTCTGTGCCTCACCTCCAGGCCCTGGGCCCTGGGCTGCATGCAGGCAGGTTCGGAGAAGCGCAGCGATCCGCTCCGTGTCTTCGCGCCGGTTGCAGTAAATTATAATGGAATCCAGGTTT + 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@rCer/554/2445_54_CCS ATGGGGGGTGATGTCAGCTCTCGACGAAAATAGAGAGGGATCGCCTGCAAATCCTCAGCTCCGGCGGGGCTAAACCTTGCAATCCCTCCCCGGCCGGCGCCGAGCCAGGGCGCAGCGGCCTCCACCGCCTCCCCCGGCGCGCACACACCCGCACACGCGCACGCACGCTCACCGTCCTCTGCCACCACTCTCTGCTCCCGCCACTCGCCGCACCCGCGAGCCCCGCAGCAAAGCACAGGTAGCAGCGGCTGCAGGGCGCATCTCCGGCGTGCGCCCTCCTGCAGCCCTGGGTGCATCGCTCTCTCAGGGAAGCCACCCTCGGAGCCCCCGGAGCTCACGCCAAGCGCCATCCCCGCTGGCGGAGGGGAGCGCGGGTCGCGCGCCGTGGAGAGCCGGGACGCGGATTAGCGCCCGCAGGAGCCTCCTGCGCCCGTTGAGGCGCTAAAGGGCTTACCCCGGAGGCGGGTGGAAGGGCAGGCAGAGGCTCCTCTTAAATACCGCTCCCGGCAGCACTTCGCGCTCACCCCGGCGCCCGCTCTCTCCTCGCCCACAGCTGCCGGATAGTGCTGAAGAGGAGGGGGCGTTCCCCAGACCATGGCATCCACGGAAGGTGCCAACAATATGCCCAAGCAGGTGGAAGTGCGAATGCACGACAGTCACCTCAGCTCGGAGGAACCCAAGCACCGGCACCTGGGCCTGCGCCTGTGTGACAAGCTGGGGAAGAATCTCCTGCTCACTCTGACGGTGTTTGGTGTCATCCTGGGAGCAGTATGTGGAGGGCTTCTTCGCTTGGCATCTCCCATCCACCCTGATGTAGTTATGTTAATAGCCTTCCCAGGGGATATTCTCATGAGGATGCTAAAAATGCTCATTCTCCCTCTAATCATCTCCAGTTTAATCACAGGGTTGTCAGGCCTGGATGCTAAGGCTAGTGGACGCTTGGGCACAAGAGCCATGGTGTATTACATGTCCACAACCATCATCGCCGCAGTGCTGGGGGTCATTCTGGTCTTGGCTATCCATCCAGGGAATCCCAAGCTCAAGAAGCAGCTGGGGCCTGGGAAGAAGAACGATGAAGTGTCCAGCCTGGATGCCTTCCTGGACCTTATTCGAAATCTCTTCCCTGAAACCTTGTCCAAGCCTGCTTTCAACAGATTCAAACAGTGACAAAGAAAGTCCTGGTTGCACCACGCCAGACGAGGAGGCCAACGCAACCAGCGCTGTTGTGTCTCTGTTGAACGAGACTGTGACCGAGGTGCCAGAGGAGACTAAGATGGTTATCAAGAAGGGCTTGGAGTTCAAGGACGGGATGAACGTCTTAGGTCTGATAGGGTTTTTTATTGCTTTGGCATCGCTATGGGGAAGATGGGAGATCAGGCCAAGCTGATGGTGGATTTCTTCAACATTTTGAATGAGATTGTAATGAAGTTAGTGATCATGATCATGTGGTACTCTCCCCTGGGTATCGCCTGCCTGATCTGTGGGAAGATCATTGCAATCAAGGACTTAGAAGTGGTTGCTAGGCAACTGGGGATGTACATGGTAACAGTGATCATAGGCCTCATCATCCACGGGGGCATCTTTCTCCCCTTGATTTACTTTGTAGTGACCAGGAAAAACCCTTCTCCTTTTTTGCTGGCATTTTCCAAGCTTGGATCACTGCCCTGGGCACCGCTTCCAGTGCTGGAACTTTGCCTGTCACCTTCCGTTGCCTGGAAGAAAATCTGGGGATTGATAAACGTGTGACTAGATTCGTCCTTCCTGTTGGAGCAACCATTAACATGGATGGTACAGCCCTTTACGAAGCGGTGGCCGCCATCTTTATAGCCCAAATGAATGGTGTTGTCCTGGATGGAGGACAGATTGTGACTGTAAGCCTCACAGCCACCCTGGCAAGCGTCGGCGCGGCCAGTATCCCCAGTGCCGGACTGGTCACCATGCTCCTCATTCTGACGGCCGTGGCTTGCCAACAGAGGACATCAGCCTGCTGGTGGCTGTGGACTGGCTGCTGGACAGGATGAGAACTTCAGTCAATGTTGTGGGTGACTCTTTTGGGGCTGGGATAGTCTATCACCTCTCCAAGTCTGAGCTGGATACCATTGACTCCCAGCATCGAGTGCATGAAGATATTGAAATGACCAAGACTCAATCCATTTATGATGACATGAAGAACCATAGGGAAAGCAACTCTAATCAATGTGTCTATGCTGCACACAACTCTGTCATAGTAGATGAGTGCAAGGTAACTCTGGCAGCCAATGGAAAGTCAGCCGACTGCAGTGTTGAGGAAGAACCTTGGAAACGTGAGAAATAAGGATATGAGTCTCAGCAAATTCTTGAATAAACTCCCCAGCGTATCCTATGGTAAATGATGATTTAAACAAGCTTTCT 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rCer/556/26_2932_CCS ATGGGGGCTCGAAGCCACGTCAGGGCAGCCCCAGGTCGGGCGCGCGCCAGCAGCAAGAGGTATAACTGTAAGAATGAATTTTAATGTCTGGAATATCAAAGAGATGCTCAGTATTCCTTCAGGTCTGGAACAAGAAGTTATCCAACTGAATAATAATCAAAATGATTATTCCAGTCTCAGCGATTCCCAGTTCCTCTTTGGATCTCAGTTCTGTCCAGAAAATTCAGAAACCCTATCAGCACCCTTGGACTTCCGGTGCCCACTTGAGACATTCAAAACAGTCACAACAGAATTCTCTGGAGGGTGAACCTAGCATTTTCACAAAGTACAGACAAAGCCCCAGCTGTTTGGAGGAGATATAAAAGATGGAGGTTTATTTCCTCCTCCTTTGTCAGTTGGAAAATCAAAAAGGCCTCTTGGAACAGTTTTGAGGAGAAAAAGAAAAGGGCAAAAGACAAATATGACAGTGAGACTCTATACAACTTTGTTTCTATGTTAGAGAAAGCATTCACAGGACGTCTGTGGAAAAGTCTGGGGAACATCTCAGTTCAAGAAGCCAATCTATTTTGGATTCTTTGGAGACTGTGGCCAAGACATTACAGAGAGACTGTGCAGGCCCAGAATGACCTGGTGTTTGAGGCAGTCCAGGACAAAGGCAACATGGAGCAGGCATCCTGGAGATGAAGAAAAGATCTGAAGCTAGACAAGCAGAGTTTAATGTAAATGAAGTCCAACCTGAAGCACCTTGAAGTTTTAGTTGCTCAACAGAGTCAGGAATTCCAGCAGCTGTGTGAGCAGCTAGGCCAGCTGAATGTGCCCAGTGTCCTAGCAGAGCTGAAGAGATTGATCTCAGTGCCTCCAGTACCCTGGGCATGGTAAAAAGACAGCGCTTCTCAGACGTCGCCACCTTTGGCCCAGAGCCTCAATCTCAACCGGGCAGGAAAAATACAACTTTGAGAAGCCAGTTTTATGGCAGGCCCAGGCCCTCCCTGCTGCATGGAATCCTGGTATGGGTTCCCTACAGCCTGGAGAATTTGGTGTCTGGGGTGAAGGAGCAAAGAATGATGCTCTCCAAGAAGAGGGCTGCACTGCCAGCATTTGGGTCCATGAAAGAAATAGGCATGTAAAGGACAAGGCAGTGCAGACTAACTGCAAGAACTGGGCTGTTACTAAAACCAGATGCCAAGAACTGTGGTTCCAGCATCCAAGGCCATAAGATTCCTAGTGATAGGGACCTGGTTTCCAAGGAGCCTCACAGCTCACATCACTGGGAGATAAACAACTTTTCAACCAGCATTAAGAATGCCTGCCAAAAATATCAAGCCCAAAGTATGTTTTTGTGTGACCCACGTGAACATTTGGTGACTAAACAGAAAGATGAGGACTGAAGAAATGCAGGGGAAAGACAAGAAGCAGCAGCCCAGGAAGGCCCACAGGGCCCACAGAGGCAGGCTCCTAGCCAGGAAGCAGAAACAAATCCCAAACCAGACCTCTAAATTCAATTCCAAATATCAGAGTCCTCAGCCTGCAATTTCTGTCCCACAAAGGCCCTTCCTGGGCAGCAGGAACCCCATGCTCAGCCTCTGCATCTGCAGTATCCCAGGAGCCCCAGAAAACCAGTCTTCCCTATTCTGGGAGGAACAGTCATGCCCAATAAGACAGCAAGGGCAGTGCAGGGAGACTCTTGCAGTTCAGCAGATGCTCTCCCAAGACAACAGGCTTACTTTCCAGCAGTTCCCAGGGGACCACCAGATGAGCTGGTTCAGTGACCTCAATCTTGATGTTCAGAGACCCCTCTATGCAAGGAGGCAGGAAAGAATTTGCTCTATGACCTGGGTTTTGATAGCAGTGATGATGATGGCTTCTGACCAGCCCACAGTTAATTTATTGGTCTCAGCTAGAAAGACAAATTGCAGGACATTTGGGCTGGCCAAGAGCAGAAAGTCCCTGAAGCCTGCCAAATACCCTAGGGTCAGAGGCCCTGCTGAGGTGGGGTCAAATGGGCACGAGGGGAGGGAAGGTCCAGCACTCTGGGTACCAAGGTGCTGCCCATGAACAAGGATTAAGTGCCATCCTTATTTGTTTGGAATGAAATGTGAAAATGGTGGTGATGAGAGCTGAGCAGCAAGCTTGGTTGTGGTGCATCTGGAGCCCCTGGGTGCCTGTACTTGGCGAAAGGTGGGCAGGCCTCCTTATGGAATACTGTGTAGCAGAAAGGGCTCTCATAAAACTTGCTGTGGCAGCATGACTCCAAACAACACTTTTGGGTCTTTAAAATATTCCCTACACCTGACCAATACATTTTCAGGCCTCAGGATTTTTTTCTTTCTTATTTTTAGCCACTTATGCTGTCAGAGTATTTGCATTTTTTGATCAGTAGAGCATATTACAGGACACCCCTAAATCTTCTTGTGAAACAGAGAAATGATAAGCCTGACAGTGAAGAGGTGACATGCACTAGCAAATGTCCAGAGCATCACTGCCCACAAAGCCATTTTTCTTCCTGGCTGCTTTTTCCCTTGTCCTGTTTTTCAAGCACTTTTCTTAAAAACTAATAATATTGTAGACCTTTGTATTATTTCTGAAGAGCAGTGGGCTTATATGGGACTTTGGCTTTCCATTTATATCTTTGCTGAAGTTTTTTGAATTTTTGCAACACAATATGTATTTTTTGTTATCAGAAATAAAACATTTAAAAGCATATATTTTTTTTCTTTTTTTTCCCCCCTGAGATGGAGTATTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGTTGTGATCTCGGTTCACTGCAGCCCTCTGCCTCCCGGGTTCAGGAGAATGGCCTGAACCCGGGAGGCGGAGCTTGCAGTGAGTGGAGATTGCGCCACCGGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCT 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@rCer/558/1799_56_CCS ATGGGGCCTAGTTTCTAGATCATGTCTGCGAGCCAGGATTCCCGATCCAGAGACAATGGCCCCGATGGGATGGAGCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTTTCAGAGTCTCTTCTCCGTGGCATCTACGCCTATGGTTTGAGAAGCCGTCTGCCATCCAGCAGCGAGCCATTCTACTTGTATTCAAGGGTTACGATGTGATCGCTCAAGCCCAATCTGGGACTGGGAAACGGCCACATTTGCCATATCAATTCTGCAGCAGATCGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTGGCACCCACTCGAGAATTGGCTCAGCAGTACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGTGCCTCCTGTCATGCCTGTATTGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCCCCCCACATAATTCGTGGGGACCCCTGGCCGAGTGTTTGATATGCTTAACCGGAGATACCTGTCTCCCAAAATACATCAAGATGTTTGTACTGGACGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCTACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAATTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACGCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTCTCTGCCATGCATGGAGATATGGACCAAAGGAACGAGACGTGATCATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATCGAGACCTTCTATAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCCGACCTCATCTGAGGGTTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCGGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAATGTCACTTTTTGAGGCAAAAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCAGGCGCCGGTCTTCTCCCAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAGGGGACTACGTCACTCAGCCTCATTTGCTGGACCAAATCTGAGGGAGAACCCCTAAAACCCCTGAGTGAGGTTGCCCAGGGGGTTGTCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTATTTATTGATTCAGGAAACAAACACAAAATTCTGAATAAAATGACTTGGAAACTG 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@rCer/560/21_2002_CCS ATGGGGGCGCCCGCATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACCGGCAGGGCGCCGAGCTGTCCAACGAGAGCGCAATCTGCTCTCCATGGCCTACAAGAACGTGTCGGGGCCGCAGGTCCGCCTGGAGGGTCATCTCGAGCATCGAGCAGAAGACCGACACTCCGACAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCGAGATCCATCTGCACCACGGTCCTGGAATGTTGGATAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAAATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCATGTGGTGATGATCGAAAACAAACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATGCAACCCACACACCAATCCGCCTGGGCTTGCTCTTAACTTTCTGTATTTTACTATGAGATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCATTGCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTGCTTAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCAGAAGGGGCTGAAAACTAAATCCATACAGGGTGTCACCTCTTTCCTTCAAGAACCTTTTTACACATCTCCATTCCTTATTCCACTTGGATTTCCTATAGCAAAGAAACCATTCATGTGTATGGAATCAACTGTTATAGTCTTTCACACTGCAGCTTTGGAAAACTTCATTCCTTGATTTGTGTTTGTCTTGGCCTTCCTGTGTGCAGTACTGCTGTAGAAAAGTATTAATAGCTTCATTTCATATAAACATAAGTAACTCCCAAACACTTATGTAGAGGACTAAAAATGTATCTGGTATTAAGTAATCTGAACCAGTTCTGCAAGTGACTGTGTTTTGTATTACTGTGAAGATAAGAAAATGTAGTTAATTACATTTAAACAGTGTTCCACATAACTTCTTAATTTGTACATTCCCCCTTACTCTTCAGGGGTTTCTTTCAGTAAGCAACTTTTCCATGCTCTTAAGTATCCTTTTTAGTAGGAATCTGGAAGTATTAGATTGAATGGAAAAGCACTTGCCATCTCTGGTGGGTCACAATTGAAATGGCTCTATATCACATAAGGAGTCTTGTATATCTGTGGCACAGGGAGTTCCTATTCACTCTTTATTTGCTGCTGTTTAAGTTGCCAACCTCCTTCCCAATAAAAATTCACTTACACCTCCTGCCTTTGTAGTTCTGTATCACTTTACTATGTATAGAAGTAGCATGTTGCTGCCAGATACAAGCATGCTTTGGCAAATTAAAGCGCATGTCATTTCTTAATACACTAGAAAGGGAAATAAAGTACACAAGTCCAAGTCAAACCTTAGTACTTTCCATGCAGATTTGTGCACATGTGAGAGGTGTCCAGTTTGTCTAGTGATTGTTATTTAGAGAGTTGGACCACTATTGTGTGTTGCTAATCATTGACTGTAGTCCCAAAAAGCCTTGTGAAATGTTATGCCCTATGTAACAGCAGAGTAACAGAAAATAAAATTACATTTTATAAACCATTACTATGGCTTTGTAACAATTGCATACCCATATTTTAAGGGACAGGTGAATTTACTACTTTCTAAAGTTTATTGATACTTCCCTTTATGTAATGTAGTAGTGATACCTATATTCTGCATTGTGCATTGTGACACACTTGTCTAGGGATGCCTGGAAATGTAAAATTGGACTGCATTTCTAGAGTGTTTACTATAGATCAGTCTCATGGGCCATCTCTTCCTCAATGTAAATGATACTGGTTAAGTGTTATATGAATAAAGTGACATT 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@rCer/563/25_1635_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCGTTGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCGAAGTCTACATCCTTATTCTTCCGGCTTCGGAATGATCTCTCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACCTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATATAACTTTTTC 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rCer/564/25_2624_CCS ATGGAGGGACATAGAGACAGGAATCGGGTTCTGGGTGACGGTGATCTGGATGGCAGACTCCAAAGCCGTCGACCGTGGTGACTCCTTGCACTGGGATGGACATACGCAAGCCGGAGATTTGGGCGGCGCTCAAATCGGGCGGGGGTGACTCGGGTTTGGACCCAGGATCCGATCAGCGGACCCTATTCAACGTGGCTCCAGCGTGACATGGCTGAAGCGCACAGGCCGTGGCTTCGAACCTCGCTGACCTCGGACGGGCTGAAGTGAATCAGGCCCTGTGCTGCAGGAATCTACCTCTCTGGCTGCGCTCCTGAAAAGGCATCTCTCAGTTCTGAATGACTTTCTCACCAGTGTGTTCTGCCGCCCTCAGTTGCTTTCTCTTCAGTGCCATCCAGCTGCTGGTTCCCCAGCTGATCTCCTTAGGACTGATGGAGAGATCAAGAGTTGCTGCCCGACTGGGCGGACAGCACCACGGGCTCCGGGGGTCCTGGCACTGCTCTGTTTGCCTCTTGTTTGGGGAACCCTGATCTTCACACTGCACGTGGCCCTCAGGCTGCTTCTGTCCTACACGGCTGGCTTCTTGAGCCCACAGCCATGTCCTCCCCACAAGACCTGGCTGGCCCTGGTCCGCATCTTCTCCGCCGCACCGATGCTGTTCAGTTACCAGCGCTCCCTGCGCGCCCCGTGCCTCTGTGCAGGACACCGTGCGCAAGTACCTGGAGTCGGTCCGGCCCGTCTCTCCGACGAGACTTCGACTGGACGCGGTCTGGCGCAGGAATCCTGAGGTGCAGGCGTCGCGCTGCATGTACCTGAGCTCAAGTCCTGGTGGCGTCAATATGTCAGTGACTGTGGGAGAATTTGTGTACCTGCGCTCCGAAATCCGCTGATGGTAACAGCAACTATTACATGATGGACTTCCTGTATGTCACCCACGCTCTGCAGGCAGCTCGCGCTGGAATGCCGTGCACGCCTCCTCCTGTACCGCCACCGCTGAACCGCAGGAGATACCCCCGCCCACGGTTTCCTGCGACTTGCTAATGGAATGCGTCCCTTATGCTCTGCCAGTATGAGAAATCTTCAATACCACGCGGATTCCAGGTCCAAAAAGACTACATCGCCACCTCCATGACAGCCAACACGTGGCTGTCTTCACCGGGCCGATTCTTCCGCGTGGGACCCACTCCGAAACAGCCTGCTTTCCCGAGGGCCCTGAGCAGCAGTTTCAGCGAATCCTGGACGATCCCTCACCAGCCTGCCCCCACGAGAACATCTGGCTGCTCTGACCGCTGCTCCAGGGCACGTGGGCCCAGGTGCGAAGGTCCTGAAGACCCAGGCAGCAGAGGCCTGGAGCAGTGGAAGGCCGCTTTCTTTGTGTCATGGACGCTGAGCCCGGGGCTCACCAGAGACCAGCAGCGTCGTTGGATGCCTATTGCCATGCCTGCTGGCTGGCGGGGCTGACCGCTGTTGACAATCTTCACCCTAATCGTCTTCTCTAACGGAAGCTGGCCTCAGCGTGGAGCACTCCTGGCCCGACTGCCCACTCAGGACACATGTGGAGTTCACTCTGGCTACAGAATGCTTTCAGCTGGGCTACTCAACAGACGGCCACTGCAAGGGGCACCCGGACCCACACTACCCGCCCAGCGGCTGCAATGGGACCTTCCAGACCAGATCCACTCCTCCTCTCTCTAGCCCTGAGGGGAGCCAAGATCTTGTCTGAAAATGTCGACTGCCATGTCTTTCCATTCTCCTATTTGGCAGAGCTTCATCCGACTGCACCTGTCTTCAGAAGCTTATCAGATCGCCTTGCAACTGGCCACTTCCGGACAGGGGTCAATTCTGCTGACTTATGAGTCGGCCATGACTCGCTTATTCTGGAAGGCCGGACGAGACGTGCGATCTTGCACGAGGGAGGCCTGCAACTTTGTGAGGGCCATGGAGGACAAAGAGAACGGACCCACAGTGCCTTGCCCTGTTTCGCGTGGCATGGACAAGCACAGCTCTGCTGAAGGCAGCCATGAGCGGGCAGGGAGTCGACCGCCACCTCTTTGCGCTCTACGTCGTGTCCCGATTCCTCCACCTGCAGTCGCCCTTCTGACCAGTCCATTCGAGCACTGGCAGCTGTCACCAGCCAGTCCCTGTTCAGCAAATGCATCTGTTTGACGTCCACAATTACCCGGACTATGTTTCTTCGGGCGGTGGATTCGGCTGCTGATGACCATGGTTATGGTGTTTCTTATATCTTCATGGGGATGACATGATCACCTTCCACATCTCCAGCAAAAAATCAAGCACAAAACGGATTCCCACAGGCTGGGGCAGCACTGAGGAGCCTGTTGATGTGGCTCCCTGTTCCAGGCGGGACAGCATTTTAAGCGCCGGTTCAGAGGGTCAGGGAAGAGGACTCCAGGCACGGTGTGGATTTCTTCCCGCCAGACTGGGCCTCCAAGACATCAATGACATCCACTACTTCTGACTCCTTCCAGCAGGCGGCTGGCTCTCCGGGGATGAGGGTGAAGATGGCCACAGCTGGCTGTCACAGGCAGGGGCAGCCTGTTTGGCCACCGGATATCCAGGCTAATAAAGATGTGTGAGCTGG 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$)$)'%)++'%#&(),,+-(*'-,*$*('-'$#))(&'+,.-'&+)*$,(#',,+#)&''*),+(',)*,)*#($')+)#'&('+()))$&%'+,*""*)'(--)(,'++(-,--,)(++$)&%&,,(**'#*+(##))(#(%%$''',--)-,+.-&*)$,,+,-+*,.---,(),)-,(,('"'),&-(*+#*)((--)+((*''(&)-,(,,-)*('&$(%'(+'&'-&&)%++.)-,--+'),#%('&'+*$++),-(,((#'(#)'%#(-,)+'+-*,)+,(&#,(--,.),-,*('&#(*$)-+.,)(,,*'+%&(+),-,*##+*)#)----('--(*&+)),)'*()',#%"$$#%,,'()(+)#)(-(#&,&&&'%%,'*&)****+#(#))+,-(&"(,'%)(+,%$&)),+(+(+,'((&*%#%+**&$,*+,(,(&,-',+-,&,(-+,+-(+*-,(%++,)..,''+$,+***(-,(*%%#(,,$,,*%),*&,),(,*#%$&',-(.)-+(&+)($&&)(((,*,,('*&+(--,,((('),((-,)+$&,**$'*'()(&)(,*-&,,-,$+*###(%(,-,&%'&&&(*&%&+'))''&)(%%)&,,)(,+,.())*)(,(&#$)'*)(*#,%'&'%()#%+)(,-''-,,+*,,(+*&&$"&##%"%++"%-,),)()+-'))+&(+(**+'*()&&'&*(*)'#%&',+,-')'-,'%#%''*.--*+%'+--.,(+-,))'$','(((+,,%&&+'+''%(*-,))%#'),','((,-(#,(++%"#),*+),'$$%*',))(),))($+(+'#&&#&''('''%&('%$$&,*'#*-),'%''$#%'*)$&$&'***-,(*,*('+*$#$%#('(#'(-,,---*,(*(*(',(,'(')$%+#'*)'&&#,'##$*'*,*,#&***)),----,&+#'))(,,--+)*(&)0,/,*0',(&#*&*.*%*,%-1.102-'/&,.--0+(.+/-0)01.,&.-++''+-&#'&'.+)./2+%*+.)'../--0-0',+/.+.,$..11-+,-0-1%1.,11-20/'(('-112.+1121)1&%1,/0.1.--0,%)'$**+*(---2/)+./10.0,010+,0',-.+/100%%).*0,,1./'..+*)++*-+',)+(,,)-*$**,-%-*,(+'),*-)$*(%*$+)).-,$%),-)(,)$&(-,+-+$+&'+*),(&#('&-,)((,-'(')**)+',*&#%'$*-,,-*(#''-,)-)+('')+(()"$%*)#(&'(((-(,*&()((*&'+,%)'*)$++--,,,),*-,.,')+--,&*(+%())$+,,*,-('$,%*-)&*,,(,,)+*+)&"',)),,+*$(()''(-'&+,+(+%$$##"(&$'&*'((+($)',&*%&+*'%(%$,'(%&*,('-+.+,'&$*--*#%,)),+,,&$+*(&(+&'%+*.1-2112/.-'(',*&),')*$&+2./--1'*,0--,+,)1-+-1.,,.*(.%+,-0,-,%..'#+1--)..1110,.&,+/-1.11,)'+.,-+1/1,1,1---2110,0&0.*+*$,-,0%*-,*(1%/+)'--//&,,-0*-02,/.#(**00%*,$,%%%0/)--,00-.,()1)10/'-)0,1-,0-11+,0-0++&)//&(%%-+1)-,-&0))+-)-0111(.-,+,&)*./.-)-',-0,.01.'*,/+11111',-0&-.--0'%++-,-/.,(&%)%")2/0+*/**()+#&*(++,/,/-+0)$,*')%'#).,+*-%*/.1.,.%+-.$--*+0+.)/**--00/01+0.2111,)*(-12+...'.1'.*0.11,++010),/00&*,0-0&-)1&/,/%&*-/%+*+*-11,1.0/01,(011.2/.11.021.)2)0,*%//*111--,&.&/'/00./%'%,-.&*0&'.1.-/2120*./--'0/,0.11+1%%%&,,1,0*('&)*.+/--++.(/,0)10*/0-,,)0%*,-.022/')/,0,./+11./1.,22111,)*,,,++*1/-0.001/%-+1/(,.-011-/,,/1$*('*(*..&-+&&%(&02,&*++*&,&.*+10),(*1,1-,/.,,$%++-.,//0).+0,))%*1+*,(1.00.+.&-,,(0'+,*1/..,10/+&/21$*0/*12./2(&,.*1/%+*$'(+-0.&&)1(,).,1.++)&-,-+-,-..,,*02--*&,*/)$)*)%11111-,--2-2./'/*0&-0(+&00/0--*&)+$,*$/1.'02,*2$.,.-/02--+000*'*).+#+/')($*#----$(*,..)&',0--0/2-1-,0/,20/-.*-/&/-0121/1*1%*+.+)/+/001(-+21)-%''%+*,'++(-/0%$00-.'./,1,1%&%../,011+%,*0-&./-++/&)&,10&**,,-+,(,,'),%*1+-/+$/+//2.0.,',&/+)1,0)+&)'+%*%0-$$)*+*,)-++,/,(+/'/--+1.,+1.++-&/-)$.-..,.2.-.'*...01*2/1-).-0-10,%.*02..,)+%.-)))*,(),0+(*$* @rCer/565/25_1790_CCS ATGGGGGCCGAACCTGGTTCCCGAGGCGCGGCGGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGCGGGGGTCCCGGAGCCAGAGGGCCAATTCCCGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCGCTGCCCGCCGGGGTCCCACCACTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAGGAGGATGACCTGAGTGAGCTGCCACCACTGGAGGACATGGGACAACCCCCCGTGGAGGAGGCTGAGCAGCCTGGGGCCTGGCCCGAGAGTTCCTCGCTGCCATGGAACCCGAGCCCGCCCCAGCCCCGGCCCCGGAAGAGTGGCTGGACATTCTGGGGAACGGGCTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCACCAGGTTCGAGCCGCCCAGTCAAGGGCCAGGTGGTCACCGTACAATCTACAGACGTCGCTGGAGAACGGCACACGGGTGCAGGAGGAGCCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCTTGGATCTCAGTGTCCCACTCATGGACGTTGGGAGACGGCCATGGTCACTGCTGACTCCAAGTACTGCTACGGCCCCCAAGGCAGCAGGAGCCCATACATCCCCCCGCATGCGGCCCTGTGCCTGGAGGTGACCCTGAAGACGGCCGTGGACGGGCCTGACCTGGAGATGCTCACGGGGCAGGAGCGCGTGGCCCTGGCCAACCGAAAAGCGGGAGTGCGGCAACGCCCACTACCAGCGGGCGGACTTCGTCCTGGCCGCCAACTCCTACGACCTCGCCATCAAGGCCATCACCTCCAGCGCCAAAGTGGACATGACGTTCGAGGAGGAGGCACAGCTCCTGCAGTTGAAGGTGAAGTGTCCTGAACAACCTGGCGGCCTCGCAGCTGAAGCTCGACCACTACCGCGCGGCCCTGCGCTCCTGCAGCCTTGTGCTGGAGCACCAGCCAGATAACATCAAGGCTCTCTTCCGCAAGGGCAAGGTGCTGGCCCAGCAGGGGGAGTACAGTGAGGCCATCCCCATCCTGAGGGCGGCCCTGAAGCTGGAACCTTCCAACAAGACGATCCACGCAGAACTCTCGAAGCTGGTGAAGAAGCATGCAGCACAGCGGAGCACAGAGACCGCCTTGTACCGGAAAATGCTGGGCAACCCCAGCCGGCTGCCTGCCAAGTGCCCTGGCAAGGGTGCCTGGTCCATCCCATGGAAGTGGCTGTTTGGGGCAACTGCTGTTGCCTTGGGGGTGTGGCACTCTCTGTGGTCATCGCTGCCAGGAACTGACCGCCCAGGTGGCCGCCACTCCCTCTGCACACCATGGACCCTGCCCTGCGCTTCCCAACTCCCCCAGGCTCCCTGTCCACTGCCCTCCCTGGTCTAGCCCCCTCCTCCGGGTTAGGGGAGCAGGGATTGGGGGTCGTGCAGCCCAGCCAGCAGGAGGGACTAAGGCCCTCTAGGAGGAAAGCCCAGAGGGAGGGGGCCCTCATTCCTTCAGACCCAGTTTTCCCCCACCCTCCTTAGTCTGCTGGGCTAGGTCTCCGCCAGGGCCGGCCTCAGTTTCTCCTCAACAGGCCTGGGGGCAGCCCTTCCCCTGCCTAGTCCCCGCCTGAGTGCCAGCCCCCCTGCCCCGCCTGCCGCCCCTGTCCAGGCTCCCTCCCCGCCACAGTGAAATAAAGCCTCCCATCCTG 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43(2302/55+33020/-4062251525.+41%1(,304/11.'-.103,64.+-15-10020+262-+31061)%-./-.06656.116521155361206030-/,/../,/54565+/+15/114./10263)1100-5125)&*35125&4311001/2441/&-(-*%1.0)//1464626121554(%0/340054/)0133666160./3*1415645046026+4/4/24.223-/545160165.45*551215615156320)01.650203/11/440033*3045*+,2536454.12465*40.%/2250,30063-$/.$0(032333046141641*/0203+.(/'034*.%212366640&320,4.40,+++6.*-/,401-65630405*114312)1(056063355636/343221/+0*'.21+4546326/.--0100324104646.))..1045-011425-441,000*.151451-(464,36410.0'22161445/*2&.-1/.+4/.$01*154152461435*51-411630442221,/14&,5306*044353362424645(*./33-141)304542/5$230546(0-463)237::96854:9194278120-377,8563897439(011484+(-4498'00358*8389-,3137(042838474198568-434339254,318:2759-33::72;:9985+5988;9:70014,/,,-131215-1157698:/5346;/,#4,:6+96718.4:88858,:95899(95496&/:582169913,,03).33:75:5/.13-54563-+:45.9776/62/,2:4:8:5-46.,..1,785-7*78583:6954622.6;916.446:54943.43*44:56967.88-88;8.664153%13-31647.899:7&.06768<24.=;29:62;:389:>95(006272<3=559:>>>)3251:69?:==99;4796:<>8=8:4=953;4;<><:5>:;4;<::897<784=5<>6.866,6485;:843=;;6<;97>60108>7932689-<>=9?1>>=>3<<=<.848:;/<6=53:;<;7>7+<:7:.6<1=:79259>>?<1>=12).18<25:=;>89999<9;609;297<<04>9:589=-:=:<;6:&;4579':=;9;8?6>59659;>9=<=<3757>76?86?;=?=;==73;54;5448>4<<>-88::?>9<1=<3>6;>4>><;:>>:=<.:25%4844()5046;6:7<=27;8?8988:>==8+;;4200046849339:9=320<<=6:><8:/;:508:>==6:>95-<5875=<9<7<0<;7194;'99:::9=67;0987:71:>32773)6;62>.5888620'589=7>>=>186;=976<079::5>>=8??>=29:<67?9;=2279?:>=:?><=<<7*0427,9<:-9>4916460670+74<00,&+2398:5;<=9?26:46=(777659;:&53)2?===.:7>>88<3><2/+9;06504587:';90541<86;491855+:;7/:8;0.5;7:>=8786%2881;:19,1883,5-225;>909'48:99(:73+>==1:87=?:<:?;7 @rCer/569/1872_59_CCS ATGGGGGCGCCCCGCTCGACTCCGGAGGCTCCCGCAGCCCCGGCGTCCGCCCCGCTGCCCCCTCCCCCGGGGGCCATGGGGGCGCCCCCGGGCTACCGGCCCTCGGCTTGGGTGCATCTCCTCCACCAGCTTGCCCCGCGCCGACTTCCAGCTCCGCCCGGTGCCAGCGGTTTTCGCGCCCAAGAGCAGGAATACCAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGGCCTGGGCTTGGGCCTGAGCCTCATTTTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCGGCCCCCCCGAGCCTCTCCGGGTCCAAGACCCCTCGCCCGGAGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCTTCTCGCCGGCTGCATTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCCCAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCGCCATTGACCACCTGGTGTTGGAGACGGTGGAGAGGCTGGGTGAGGCAGTGAGGACAGAGCTGACCACCCTGGAGGAGGTGCTCGAGCCTCGCACAGAGCTGGTGGCTGCTGCCCGAGGGGCTCGGCGGCAGGCAGAGGCGGTGGCCCAGCAGCTACAGGGGCTGGCCTTCTGGCAGGAGTGCCCCTGAGCCCCCTGCAGGTGGCTGAAGATGTGTCCTTCGTGGAGGAATACAGGTGGCTGGCCTATGTCCTCTTGCTGCTCCTGGAGCGCTGGTCTGCCTCTTCACCCTCCTGGCCTGGCGAAGCAGAGCAAAGTGGCTGGTGATCGTGATGACGGTCATGGAGTCTCCTGGTTCTTTGTCCTGAGCTGGGGCTCCATGGGCCTGGAGGCAGCCACGGCTGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCTTATGTTCTGAACCTGACCCAGGAGGAGACGGGCTCAGCTCAGACATCCTGAGCTATTATTTCCTCTGCAACCAGGCCGTCTCCAACCCCTTCCAACAGAGGCTGACTCTGTCCCAGCGAGCTCTGGCCAACATCCACTCCCAGCTGCTGGGCCTGAGAGAGAAGCTGTGCCTCAGTTCCCTTCAGCGCAAGAAGGCCTTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAACTTTCACCAGTTGGTGGCACTGCTGCACTGCCGTGGCCTGCACAAGGACTACGGCGCAGCCCTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTGCTCTTCTCCCTGCTGTCCGCGGGAGCACTGGCCACCGCGCTCTGCAGCCTGCCCCGCGCCTGGGCCCTCTTCCCACCCAGTGACGACTACGATGACACAGACGATGACGACCCTTTCAACCCGCAGCAGGAATCCAAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGAGCCCTCCTCCCTGCCGGACTGGACCCTGGCTCCCCTCTTCGTTCCTTCCCTGGCTGCCGGAGAGACCCCACTAACCCAGCCTGCCTGGGCTCTGACCACTAACACTCTTGGCCACGGACAGCCCGCACAGGACCGCCTCCCTGTCCTTGGCCTTGGGAATAGCTGAGGGGGCAGACTAGGGAGTAGGGCTGGCAGGGGAGGGGGCAGACAGCCTCACACCCTTCATCTGGCTGCCGGTCCATCCTTGGAGGGACTGAGCTGGGGGCGGGGACATGAGTCCCCTGCTGCCCTGCCACTCCCAGTGGGCTCTGACCCCCTGATCTCAACTCGTGGCACTAACTTGAAAAGGGTTGATTGAAAATAAAAGGGAAGACTATTTTAC 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@rCer/572/25_1531_CCS ATGGGGGGGCGGGGCGCCGGGCAGGTTCCTCAGCGTTCCGCGGCGGCGGCGGCGGCGGCGGTGGCGGCGGCGACGGCGACGGCGACATGGAGAGCGGGGCTACGGCGCGGCCAAGGCAGGCGGCTCCTTCGACCTGCGGCGCTTCCTGACGCAGCCGCAGGTGGTGGCGCGCGCCGTGTGCTTGGTCTTCGCCTTGATCGTGTTCTCCTGCATCTATGGCGAGGGCTACAGCAACACCCACAAGTCTAAGCAGATGTACTGCGTATTCAACCACAATGAGGATGCCTGCCGCTATGGCAGTGCCATCGGGGTGCTGGCCTTCCTGGCCTCGGCCTTCTTCTTGGTGATCGACGCATATTTCCCCCAGATCAGCAACGCCACTGACCGCAAGTACCTGGTCATTGGTGACCTGCTCTTCTCAGCTCTCTGGACCTTCCTGTGGTTTGTTGGTTTCTGCTTCCTCACCAACCAGTGGGCGGCCACCGACCCGAAGGACGTGCTGGTGGGGCCGACTCTGCGAGGGCAGCCATCACCTTCAGCTTCTTTTCATCTTCTCCTGGGGTGTGCTGGCCTCCCTGGCCTACCAGCGCTACAAGGCTGGCGTGGATGACTTCATCCAGAACTACGTCGACCCCACCCCGGACCCCAACACTGCCTATGCCTCCTACCCAGGTGCATCTGTGGACAACTACCAACAGCCTCCCTTCACCCAGAATGCGGAGACCACCGAGGGCTACCAGCCGCCCCCTGTGTACTGAGTAGCAGTTAGGGTGGAAGGGGACAGAGAGGGCCTCCCTCTGCCCTGGACTTTCCATGAGCCTCCTGAAACTGCCAGCCCCGTCTTTCGCCTGTTCTACCCTGTGCAGCTGACACACAGCTGAAGAGCCTCCCAGCCTAGCGGGGGCTGGCAGAGCCACACAGTGCCTGTGCCGGAGGGCTTCAGTCAGCCTCTCACTCCTCCAGGGCACTTTTAGGAAAAGGTTTTTAGCTAGTGTTTTTCCTTGCTTTTAACGACCCCAGCCCCGCCTGGAGTGGCTAGAACCAGCAGGCACCCATGTGCTGCTGACAAGTGCTCAGCTTCCCTGGCCTGGGTCAGGCTGTGGAGCCGCTGTTATCTGCGTTCTCTGCCAAAGACTCGTGGGGCCATCACACCTGCCCTATGCAGCGGAGCTGGACAGGCTCTTGTGTCCTCACTCAGGTTTGCTTCCGCTGTGCCCACTGCTGTATGATCTGGGGCTGCCACCCTATGCGGTGCCTCTGGCTGCCTCCATGCGTGAGGCGGGCTGGTGCTCACGGCACTTCCTCCTTGCTCCACCCTGGCAGCAGGAAGGCTTTGCCTGACAACACCCAGCTTTATGTAAATATTCTGCAGTTGTTACTTAGGAAGCATGGGGAGGGCAGGGGTGCTCCATGGCTCCCAGACTGTCTGTGCTGAATGTATTATAAAGCCTTGGGGAGATACCCAGCCCTGGATGCTGTTTGGAGACAGAATAAATGTTTTCTTAG + IC1KE:EFIF/JCGJGHJCKCEFGJ=JJ;$AJJ8GIGG%F-C9I7GKKAKI4G1B8ICIJ>KIKGKJAIJJHFKJKKJJFJKIKJKIIJ,BF9GBBK?FJ;AJCIKK(GKI=K9JJIBKJK0IFKIHGIDHDI'I7KJDK4J@IIK9KIKKKKF9KCKJKCJJIJG@@BGI@KK7HIIHJ=ACE)IHJBHCHB'BEE1KKJJK0IKKEFHGJJKH,JJK:GJDDG=KFIIJDJKKJJ?KFFBF)DCKE@GDHGD0JF-%?JIJKJHHKJ4KHE7<1EJKBH0ADHCB=4?6IJKIIEH8IFF@D0I>3GH:&FDE6DICBCD;JJFCJ?A8H<@HCF?GJJHCJI2DG?KGH+HA;EHGKHKDFGCBIKKEKJ?%GC=5?@IDIDHA.FDHIFIAIEBDGI7E@?DJF@@KJ6H>C$HCF$FHFDH@FEGD-J1'FA(AJJGGD,JGD@KIB1@4%G;5;I?,DB.JJC0JGJBG,EG=$HGJHJI5KGIJCJFFDJCHG?FKIFGJJGKJKJDHIKJHJJIKKEJIIF?IE;IJIE'HHKC=/HFIG5:>7JJHGE-G'CF&IJCGKJCEBJKD(D@IFHICG6CFEHG?GKJII6GKIG?J;KKKBG8IKKHGIKKKIGJ-FHJF>IAJCA9HEFDK=CD4IDJHJ-DHA?6EC3EC?B2=><9<8>%B;:B?>E8H>GAED@CBGECE?2:A4=6=<08<99/0*%9>97A'FHHCC-:A8BBBKJGCH4382ABAAAA&00HGBB8C0>4%;?C%>D=GD?H7E@C)9CB.C7::0:57?+?3@47;7C(5D<9;6=+;>9;?<7;>44>=<7<;*;:4:989@;2=<4?<4.:;1#6A=(<%?*36089+<88=B.A43DEBD,D96699AA4@=<7:?1B;2B:B;@?180&1*<0?C5>ACB>67G?4BDE)C>@?>C==DD=<-@A6?@5=;B?D6A6<<8&@5CF7@C>>D7?+6&==<;F9:)GDE515)@9<0FBG9>FA=8DGGBGGD? @rCer/573/0_1387_CCS CCACCAGGAAACTGGAGCCCACGTCCACCTCGTGCAGGGATGCCGCCCTGGTCCCACGGTGGAATCAGCTGCTGGTCCATCGGAGGATCCCAGTGTGAATTTCCTGAAGAACGTGGGGAGAGCGTGGCAGCCGCCCTTAGCCCTCTGGCATTGAAGTGGATATTGACGTGGAGCACGACGGGAAAAGAAGCCGCCTGACCCCTGCCTCTCCAGAGAGTTCCAGCACAGAGAAGAACAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAAGTTGAGGGCGCCACGCAGTCTCTGGCAGAGCAGATGAGAAAGATCGCCTTGGAGTCCGAGGGCGGCCTGAGGAGCAGATGGAGTCTGATAACTGCTCAGGAGGAGACGATGACTGGACCCATTTGTCTTCAAAGAAGTGGACCCGTCCACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGCCAAGCTCTCTGGACCCTCCCAGGAGGGACCCACAGGCTGAAGGAAGCTGCCTTGTACCCGCATCTCCCACCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAGATGCTGTCCATGGGCTTCTCTGACGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAATTACGACATCGGGGCGGCTCTGGACACCATCCAGTATTCAAAGCACTCCCGCCATTGTGACCGCTTTTACCCACCTCTTCTGTGTCCCCCTCTTCGTCTCGTAGCTGTTAAGCTAGTGTAGAATTGCAAGTCTCTGTACGGCCAGTTTCTCTGCCGCCTTCCAGGATCAGGGGATCAGGGTTAGGGTGAAGAAGCCATTTAGGGCAGCAAAACAAGTGACATGAGGGAGGGTCCCCGTGTGTGTGATGTCTGAGAAGCAAGACCGGTCTCCTGGTGCTCTGGTTCCCTGCAGCAGGCTGGGCCTGCGAGACCTGAGGCTCACCGCAGGCTCCTGGCCCCTCCCTGCAGGGGCCACATTAGCAGCCCAGACATAGCTTGCCTAATGGCCTTCCACTTCTCTTTTAAATGACTCGGAGTCCCTGACATTAGTTGATTTTCTGCTAGAGACCTGGTACGCTCTGATTTTAGATAAAGGAAGCCTAGGTGTTGTTGGCGGGTAAGCAGGGGAGGCGGCTGTCCTGCACAGGCAGTGGGGAGGCCGGGCAGCCAGTGTGGTGGCTTCCTGCTGGACTGAGAAGGCTCATGCAGGGCACCCGTAATGTTGGTTTCGCTGAGAGCTGCCTCCTGGTCTCTCCACCACTGTAGTTCTCATTGCCAAACCATCAGCTGCTTTTAAAATAAGATCTCTTTGTAGCCATCCTGTTACGTTTGTAAACGATCTAATAAATGGCATCAGCACTT + S/3(44).'9633(42>:FDBE8$:91-1%@:6HJ7DIE*JC:>%7*0@(ABFACACFE=>IB&??CIABF0FFHCFHBF9A@D6F2EF6EAC7HE8A6<>(?@>@>DDGG=BIFD?:IC6FHDIBC3IJBA3'DCC=HI;HAEFEIFG3D>>@AFAJH0BED-)1&==$EGCA8F@6GD@A@>80@HF@I4B=;6-FECE=>@4B;CCD><7>CDC3<-8DC4E7>78B8F*H2G@E:>55?=:/BFC:HI5J@3I(>A=$@--5)8?DE4GI>?3GB?GE@FG=BE:(?CD@?G;1;BG-5&(JFCCEE>6E-BBJ?$@?@6A:CEDDDIE7ABB=?*F6A;0@H@8,D<=F9B?=5/@,/0'-G;AHIE35+BC5GJE1GJIA8,H@&;@)*5->,G80:9AC;HAAB1IG=>HCE>HD9:3HH<9?C$=;EGH=5IIFDB97F7HFC0GCBI5FE-CC-FHBC5H=BDC%C<.8F;GI7F7GGEDIE8I=E<:G?:,>8A@FGFD6F<35?FGF:6=@JBG<0@4;;?<:?>?H1IFGGCJ9G7ACG=BAAI7@@=B@02(EE:JH??@@H-DFA?HFFJI6G9::)EE:9>;0@?%C00B?;4BB5E9EB:=?8>A?C*DEF+))6:9?+078>%?B@;AB3(A93BC(:>=4>=D3E==F?9EGF)CFFF>BD;2B8?7B;A5C$9.81748/956:;?@BG9CBE@6F:5>>C=@FD6#862CC'C(FFB@9DD8AE<%C?70?:=8.E?BCC;4D=9@>AA7?BC1B=ADF?E6(B3A8A1@6=*<:8<+ACB=FDDFF:AA2@1*<)DD/==A6+B49;2<;?)987=?(:/6C;';=@1>959(8:=:1?B=C><=<2@6,64::58>35%;94:9,9+=,>>/94A9<:*=>=2&+?<2:13A65><9=:6*012:<;C8>9?A@<,-&452-7:6>4C?2=3:>;;9:=B*=>>8@??:>>A7?:5@3CC0,<8:C748:;<2;>;?5@A@@;A?:6;-:7;:%#-;>'6644>5::7:7= @rCer/574/2954_58_CCS ATGGGCTGCCTCGTGCTCACCGACTTCGGCATCGCAGTCTTCGAGATCCCGCACCAGAGTCTCGGGCAGCAGCCAGCACATCCTCTCCTCCCTGCGCTTTGTCTCTGCTTCCCGCATGGCGACCTCACCGAGTTCGGCTTCCTCATGCCAGAGCTGTGTCTGGTGCTTAAGGTACGGCACAGTGAGAACACGCTCTTCATCATCTCAGACGCCGCCAACCTGCACGAGTTCCACGCGGACCTGCGTTCATGCTTTGCACCCCAGCACATGGCCATGCTGTGTAGCCCCATCCTCTACGGCAGCCACACCAGCCTGCAGGAGTTCCTGCGCCAGCTGCTCACTTCTACAAGGTGGCTGGCGGCTGCCAGGAGCGCAGCCAGGGCTGCTTCCCCGTCTACCTGGTCTACAGCGACAAGCGCATGGTGCAGACAGCCGCGGGGACTACTCAGGCAACATCGAGTGGGCCAGTTGCACACTCTGCTCCGCCGTGCGGCGCTCCTGCTGCGCGCCCTCTGAGGCCGTCAAGTCCGCTGCCATCCCCTACTGGCTATTGCTCACACCCCAGCACCTCAACGTCATCAAGGCCGACTTCAACCCATGCCCAACCGTGGCACCCACAACTGTCGCAACCGCAACAGCTTCAAGCTCAGTCGCGTGCCGCTCTCCACCGTGCTGCTGGACCCCACACGCAGCTGCACCCAGCCTCGGGGCGCCTTTGCTGACGGCCACGTGCTCGAGCTGCTCGTGGGGTACCGCTTTGTCACTGCCATCTTCGTGCTGCCCCATGAGAAGTTCCACTTCCTGCGTATCTACAGCCAGCTGCGGGCCTCGCTGCAGGACCTGAAGACTGTGGTCATCGCCAGACCCCTGGGACGGGAGGCAGCCCCCAGGGCCCCTTTGCAGATGGCCAGCCTGCTGAGCGCAGGGTCAGCAATGACCAGCGTCCCCAGGAGGTCCCAGCAGAGGCTCTGGCCCCAGCCCAGCGGAAGTCCCAGCTCCAGCCCCTGCAGCAGCTCAGCCTCAGGCCCAGGGAAGACTCCGGCCCCAGCAGAGACCTCAACTTCAACTTTGGTCCCAGAGGAGACCCCAGTGGAGGCTCCAGCCCCACCCCCAGCCGAAGCCCCTGCCCAGTACCCGAGCGAGCACCTCATCCAGGCCACCTCGGAGGAGAATCAGATCCCCTCGCACTTGCCTGCCTGCCCATCACTCCGGCACGTCGCCAGCCTGCGGGGCAGCGCCATCATCGAGCTCTTCCACAGCAGCATTGCTGAGGTTGAAAACGAGGAGCTGAGGCACCTCATGTGGTCCTCGGTGGTGTTCTACCAGACCCCAGGGCTAGAGGTGACCGCCTGCGTGCTGCTCTCTACCAAGGCTGTGTACTTTGTGCTCCATGACGGCCTCCGCCGCTACTTCTCAGAGCCACTACAGGATTTCTGGCATCAGAAAACACCGACTACAACAACAGCCCCTTCCACATCTCCCAGTGCTTTGTGCTAAAGCTTAGTGACCTGCAGTCCGTCAATGTGGGGCTTTTCGACCAGCATTTCCGCCTGACGGGTTCCACCCCGGTGCAGGTGGTCACGTGCTTGACGCGGGACAGCTACCTGACGCACTGCTTCCTCCAGCACCTCATGGTCGTGCTGTCCTCTCTGGAACGCACTCCCTCACCGGAGCCTGTTGACAAAGGACTTCTACTCCGAGTTTGGGAACAAGACCACAGGGAAGATGGAGAACTATGAGCTGATCCACTCTAGTCGTGTCAAGTTCACCTACCCAGTGAGGAGGAGATTGGGGACCTGACGTTCATTGTGGCCCAAAGATGCTGAGCCAGAGAAGGCCCAGCCCTCAGCATCCTGCTGTATGTGCAGGCCTTCCAGGTGGGCATGCCACCCCCTGGGTGCTGCAGGGGCCCCCTGCGCCCCAAGACACTCGTGCTCACCAGCTCTGAGATCTTCCTCCTGGATGAGGACTGTATCCATTACCCGCTGCCCGAGTTTGCCAAAGAACCGCCGCAGAGAGACAGGTACCGGCTGGACGATGGCCGCCGCGTCCGGGACCTGGACCGAGTGCTCATGGGCTACCAGACCTACCCACAGGCCCTCACCTCGTCTTTGATGATGTGCAAGGTCATGACCTCATGGGCAGTGTCACCCTGGACCACTTTGGGGAGGTGCCAGGTGGCCCAGCTAGAGCCGACCAGGGCCGTGAAGTCCAGTGGCAGGTGTTTGTCCCCAGTGCCGAGAGCCGAGAGAAGCTCATCTCGCTGCTGGCTCGCCAGTGGGAGGCCCTGTGTGGCCGTGAGCTGCCTGTCGAGCTCACCGGCTAGCCCAGGCCACAGCCAGCCATCACCGCCTGCCGTGTCTAGCCTGGTGCCTACTGGGGCAGGGCAGCAGGCTTTTGTGTTCTCTTAAAATGTTTTCTCCTCCTTTGGTACCTTAATTTGACTGTCCTCACAGAGAACGTGAACGTGTGTGTGTTGTGTTAATTCTTTCTCATGTTGGGAGTGAGAATGCCGGGCGCCTCCAGGGCTGTCGGTGTGCTGTCAGCCTCCTGCAGGTGGTGCGGCCGTGCACACCTGTGTCGTGTCTGCTGTTGTGGGACTGTTGTTAACACGTGATGCTGTGGGTCTGACTTTCTCTTCTACACGTCCTTTCTTGAAATGTTGAGTCCAGTCCTTTGTTGCTGTTGCTGTCGTTGTGGGCATCTTGCTGCTAATCCTGAGGCTGGTAGCAGAATGCACATTGGAAGCTCCCACCCCATATTGTTCTTCAAAGTGGAGGTCTCCCTGATCCAGACAAATGGGAGAGCCCGTGGGGGCAGGGACCTGGAGCTGCCAGCACCAAGTGTGATTCCTGCTGCCTGTATTCTCTATTCCAATAAGCAGAGTTTGACACCG + ;8==)6/5>298>=869927.9=8=3>>49:8>:8158:=2:>6>>94=4>;8723$0/86,<7/(628>52?=706295963;88:48;=12583:98';=2$::=;:8<=3>?=<86;4,:7><7=45:9>9>=-<5=?4877:=<,2:479<4552%6?:78;::=9?9641751=:9:<948<1:45:8=8?;69:;72;><89<96=46?5=9?=:=069998;4=72+8>=9;?<><:<:7<-'/;3;+>;;;68/1039:::;7;65,*449:4958326-599.47876414777-1-6:6717.385559:6;97:6::785685099776*/0:7:9.&622958455775,332,6.)64:52,8;7835-5.837.1/7'8/3353307.,54139:9:9662695-.392.77-8:971835&'63'53357::99663&2178569477*:6784942.966417::6;8:514875:56:9893965,'166218+5/2,/7/;35-7;915:57908:2292.3%.07592686;::3,345/466&6:6-806::8556988:78775%9678/87-58$,2:754:4:/8992611/$59745126844-+21/52/+0**6'55,5789:72-781:8;8:84639009/411.53++885424(.7.2257:65246:72-5:,59693,303&6727856:8:3:4875:773785:4:7183289594465/'57838595-.8;682482779:419876(.274-2+35%5/657194565:763787:7:98563827;8792998336467144-.89092,/506(.5847::2'74988/6;52.134/77.2003766/047)444#04%6861.7948.6.83/756:6,0-859;69:-:41/106/3-1./3621)98-1728960277211577/5,11300)*%-1$-776%1*,.8;3)4242/1-9:91/64+8:76$-2348.76.///4&433+65:79594:10.2&46/46064;9389474)471366(548081952:7/93:5:33386829,426./:99;204686*796/30-6132%/-46-/6943/&739566667;54/69:/353:37:0:8734;8755-378725493(25366/:6774908,9:65*483*)+4(2281565::1)330/+67:;;49(9:66/5:55506558:88-5502.6:994045663458/5'4478*6::;795:844:865:+6:96:5;825(/*6543948209:2:633)369.';;87759778539916699197%49::768:53/678/338:89755657&98847776:24:99;543)895:672,2,3583972:8/91471;9,95)6)/,'-31'-:99.3-814655452&77.843.992:5700(58/6974373&330'-2678:3,'--(3:::54/57:8449/::890978:;;38685&562953236:658--('6/4477577933364&75:8621*59339:9:69:9991+3.9:-1856.,34.734968:::76::;6491,:59;457::67-05.488::943,264757+8681,166,85440:446:4:69.85.&0$:44:99:44/38-429;96::14.26,843049:7;8:0621:8287*4::54*374743:5686:99939:38583/15.7:945/3-#39789753;7:0360;;;99966347:68:::581,%87+63&882#504957533836,7498+2568,-364775919734824309:97;66*93;7/:485-(66&45*02/26&29:/48251:5484*4597&96:9266,:3854387650-10859498936:90995/4.855527355/8:;38626:65679:02/1$126785/.3,67511*10'00+51.9244308(&'/9554.75.1.266,58119;59877286:1:883-34-25-7713-4&68626247-2//99745;3759640859-7906551%,*56485746765/*7242,4(669869984-715745541230993-)6287733993:8855:3.6;38537728932710433487:78254709+874957890248:5957.)/3+274045(23.,5/762765-221622'+4197855661-3:87421553(/889964:196/07935;34,72998158;3:445:8635214-411.259;56:4315985:3249:::75832/(2485:508:::55)34-369995687::)578:23/844:55937//04014445,676+47::9/9:9933.7:220*-925.:27:15::2949654468693:9:6378.3668302:48:56:79*88:/0672695739:366*5861360,%58+26305609:1789,,859:;8:95::68::6/50597/5417878/868949/926:1757874:92989:/15:::733:765'2,063/9;8527848857569.397;761985503-,309-5254998575;959;6:9;663828675:5-9:94976:52::1:2*79/983.30654:45:8:;68:09:7.'26*5358332:47457766-887.02923481256;:5685:1586764779:58995836544%/-.46+77:/662963/2&287*78449:4770478/*'55$/9455/919591536::;9656987475-2/464.6:3281//+00++45,/)+')0%8597007:47287;66 @rCer/576/2017_54_CCS ATGGGGCTCCCCGGCCTTGTTTTGCTCTGGCATCGCTGCCGGGGAGGGAGCGAGGGGGCCGGGCACCAGGCGCAGAGGCAGGGGAATGGCCATGGAAGGGTTGAGGGCCGCGGCGGACAGAGGGCCCAGCCGTGATCCAGCGACGGGTTTGGGGCTCCGGGTGGGGTGGGGGGCAGCGGGCGGCGGCAGCAGTGGCCGCACATCTGGATGGAAGCGAGCTTTGTCCAGACCACCATGGCTCTGGGGCTGTCCTCCAAGAAAGCATCCTCTCGCAATGTGGCTGTGGAGCGTAAGAACCTGATCACCGTATGCAGGTTCTCTGTGAAAACGCTGCTGGAGAAGTACACAGCGGAGCCCATCGATGACTCATCAGAGGAGTTTGTCAATTTTGCAGCCATTTTAGAGCAGATCCTCAGCCACCGCTTCAAAGGTCCAGTGAGCTGGTTCAGCTCAGACGGGCAGCGGGGCTTCTGGGACTATATCCGGCTGGCCTGCAGCAAAGTGCCCAACAACTGTGTGAGCAGCATCGAGAATATGGAGAACATCAGCACAGCCCGGGCCAAGGGCCGGGCATGGATCCGGGTGGCACTGATGGAGAAGCGCATGTCAGAATACATCACCACGGCTCTGCGCGACACCCGGACCACCAGACGGTTCTACGACTCTGGAGCCATCATGCTGCGGGACGAAGCCACCATCCTCACCGGAATGCTGATCGGACTGAGCGCCATCGATTTCAGCTTCTGTCTAAAGGGGAAGTCCTGGACGGGAAGACACCCGTGGTCATCGATTACACGCCCTACTTAAAGTTTACACAGAGCTACGACTACCTGACCGACGAGGAGGAGCGGCACAGCGCCGAGAGCAGCACGAGCGAGGACAACTCGCCCGAGCACCCGTACCTGCCGCTCGTCACCGACGAAGACAGCTGGTACAGCAAATGGCACAAGATGGAGCAGAAGTTCCGCATCGTCTACGCGCAGAAGGGCTACCTGGAGGAGCTGGTGCGTCTGCGCGAGTCGCAGTTGAAGGACCTGGAGGCGGAGAACCGGCGGCTGCAGCTGCAGCTGGAGGAGGCGGCGGCGCAGAACCAGCGCGAGAAGAGGGAGCTGGAAGGCGTGATCCTGGAGCTGCAGGAGCAGCTGACAGGTCTGATCCCCAGTGACCACGCCCCTCTGGCCCAGGGTTCCAAGGAGCTCACTACACCCCTGGTCAACCAATGGCCCTCACTGGGAACGCTTAATGGGGCCGAGGGCGCCAGCAACTCCAAGCTCTACCGGAGACACAGCTTCATGAGCACGGAGCCCCTGTCAGCTGAAGCCAGTCTGAGCTCGGACTCCCAGCGCCTGGGAGAGGGCACACGGGACGAGGAGCCCTGGGGTCCCATTGGGAAGGACCCCACGCCCTCCATGCTGGGCCTCTGCGGCTCCCTGGCCTCCATTCCCAGCTGCAAGTCCCTGGCGAGCTTCAAATCCAACGAGTGCCTGGTGAGCGACAGTCCCGAGGGCAGCCCGGCACTGAGCCCCAGCTGAGGAATGGCATGGGCAGTGCTAGCCCCACCTGCCAGGGGCCATGGACACCTGCCACCCTTCTTCAACAAGAGTCCCCCAGTCCAGGCTACCCTTGCAGAGAACGCTGCCCACCAAGCCAGGGTTCTCTCGGGGAAGATCCCCTCTACTCACCTTAGCTTCCTTGCCTGTGGCAGCACGGGCTGCGGAGGAAAGCAGGCTGAGCCAGGAGGCAGGGGTGCCCAAGCCGCAGGGACCCCTGGGGAAGCCTGCTCCATTCTTCTGGTGACCCTGGCACTCCCTCACTCATCTCCCCTTCCCCCTCAGGAGCTGGTGGCCCAGTTTCCACACCCCCACAGCCTGTCCATCTGTCCTGTGTATGCCCTGGAGTCACTCCTTCCTCAGCCCCAGGGCAGGAGCTCTGCGGGGGATCAGGCAAATAAAAACCAGAGGAC + 49?A?:=>>C@'A=C>B;29;B1GEBB=>BAAB9.<@=$.4>++5EB::832.%5(A>BA>E@F331>ADBB@@F*EC:@?=6ABBD?D>A@>FD??9::@.77=,ADGE?A?A?4?.:BA@DB6?ACB@@A9:9B<8@=B9>=A?=@D6<@86B7<=D@FCA5AEE;;=AFD==:97;C<68:=;4A?;7:6>>?6:@FA@B=@AGAAD4=.8-5=89AAE?FA?:@EE:>?C==?C;2=927?3>A9?:E0AA=?E=EDCEC;DFC@9AAAB6A8:3A:FB:3C>BC;;45B?=90;@@6@>C:>B=9@EDG/BABBEA=56928<>E=6D=;74@DDCA@B=2@9EA>AC?;@3F?8BB*??DB6=?D=<6=8:@6B83AFBDAC:;?;G?BCBCA?:9B?AFC3C>FE?5,5B==:BCA<7<098EDGCAB:FAD@@>C;D>@C;AD:F><4=AB<>FC:?=EF@G=C79>@4@>72B6?BF252?@?@A>>?@;0<9EEDBGA>EFBBG>@C?E>9274>A>:@<@><*?A99F;?@C<8>F=>;C7CBB;<9:8ADF>B;967D6:5:@BF=?:A88A@?F@?;79@?FC>CAA?=:9BAACCB2:?@B=C@EGEEAC;@:3;16FFGGB8&<5;;AE@@BB<>:5A>>B69D?>;>CG@???:F?D0;8E@B:82<@B@A=8?55=DA@?89>==9>9=<6..,27<;=6E=;=@<:B9=<=?FD?7<,CD@8.?B==5/993<:8;@C2A;>8ED:=FC=AD?ADE9>E;9:;;<558782?:3@=B@::8=.+0A=AA<9=C=>E?2:>C=B;>?BAAAA33F?D;EAE?BC@B@A>@0DAB@:@CCE6<,49>@AAA?E>A0B<8B;;>;CBE:DGE8F>F??DE?FDG;=62D=A*E@46@IHIBHD=4?6A>B<<,F@?A@4<@DA442:A8@G=GIE@AGGE7CIBCCDFFBC3FFAI@8:@A5;>>;882=IEII<>?I?A>AGHABCIEGIJD:7F@8:AFFAH?IFDE=B>>FD7F>BF;CFB9G,;G5FFFH;EE;?C>DD5788%:FDB?;:;307>A:E8J=A*+G:5:;9E(@CC?HB3:DEAA>AID99@;>3=9=DB?=6C>EFIAC:B9BF:BA=A@F@DI@4BA=F<8<>6BGCB2B9:BD@=>/54;21E@?D;9A@6C;@=CA>C/@>7F=DB@AABA<>38=@6ACCB@88@:5C8E@979@>@>F?7=@;:B4E=CFFBBC@D5@9@?:-BEB<17ADC>@GFB5D49BDABACB9<=0A>2@7AB6:>267<4;E@?;1&E9:C9;1;93=;3<=;C9<<><71A??=6;4?52-669&9A:FEA;@>?5A??72.9*?BA@@D??>=(A@3?;@B?:DGADEC>:?846<6(:CG=A-=3@AD?B>AEB546=<86*=<4;>E98? @rCer/578/2220_59_CCS ATGGGATTCAACCGGGGAAGGTGAGGCGAGTGGAGGCTGGTGCGGAACTTGCCGCCGCCCCCAGCAGCGCCGGCCGGCTAAGCCAGGTCCGGGCAGACAAAAGAGGCCGCCCGCGTAGGAAGGCACGGCCGGCGCGGCGGAGCGCAGTGATGACTGGGCGAGGGGGCCGCGCGCTGCTGGCTCTGTGCGGGGGCACTGGCTGCCTGCGGGTGGCTCCTGGGCGCCGAAGCCCAGGAGCCCGGGGCTCCCGCGGCCGGCATGAGGCGGCGCCGGCGGCTGCAGCAGGAGGACGGCATCTCCTTCGAGTACCACCGCTACCACCGAGCTGCGCGAGGCGCTCGTGTCCGTGTGGCTGCAGTGCACCGCCATCAGCAGGATTTACACGGTGGGGCGCAGCTTCGAGGGCCGGGAGCTCCTGGTCATCGAGCTATCCGACAACCCTGGCGTCCATGAGCCTGGTGAGCCTGAATTTAAATACATTGGGAATATGCATGGGAATGAGGCTGTTGGACGGGAACTGCTCATTTTCTTGGCACAGTACCTATGCAATGAATACCAGAAGGGGAACGAGACAATTGTCAACCTGATCCACAGTACCCGCATTCATATCATGCCTTCCCTGAACCCAGATGGCTTTGAGAAGGCAGCGTCTCAGCCTGGTGAACTCAAAGACTGGTTTGTGGGTCGAAGCAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTATGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTCTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACACGGAGTGGTAGTGCTCATGAATACAGCTCCTCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCAGCCATGTCTAACCCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAATGGTGGTGCTTGGTACAGTGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTCAAAGGATTTGTCCGAGATCTTCAAGGTAACCCAATTGCCAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAAGTGGCAGTTCCTTACAGCCCTGCTGTTGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGCTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTAATCATTTAAATATTAATCAACATTACTTAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTTCATTTTTCCTACCTATATTACACAAAAAATATAGAAAAGATTTAAGTAATTTTGCCACCCTAGGCTTCAATGCAATATTCTGGTATTATTTACAATGCAGAACTTTTGGGTAATTCTAGCTTTAAAAATTAGTGAAGTTCTTTTACTGTAACTGGTGACAATGTCACATAATGGATGCTATTGAAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGGCTTAAACAATTCAGTATAAAATTGTCGTTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGAAGAAAGGTAAATGTTTACAAAGAGGTTTTATGAAAGGAATAAAAATTGACTTCTTGCTTG + *01)/14042.34245)4./021440+)*,/)'0435/4.5626.2'03040112(/-212'(54243)3-5243(+)04/0/$24.5555-/0.-/,+((),(2)60423(041.-646022-521(2.3*0$22.5542540),,..662.556602432364-*,325/2384397585.675.43//5%5485;986:85597:729774562:;:85895+13450,+//,/17-504,1554,3154605.1'41.3-122+32262662443(405454663622$(040,.*6)20'422--'/-),)&&#"-+/,+/)-00,.33+43+.--/.,..1*+,.+.*.1,0/0201/,.,-10.,/31-+44.5.400+///.,//*-/,1.30110+10)*(1.,**+-&+**..-).+0/-)0(11/3./.,.*(,,3/12.-40--(1.10/-0+05563321200-033*6612,,1,,*+.1-1401.-634-/0,+)(./1-0/443534300+$(3*-(-*''./0/(*/.1,*%)++*$0+.0,+#)+.+-+./,//025531//.()+)++*))'%)10*/*'+*)30/,05,115.0%%#:75640.281.1404265543503-+(51/12+(/.)./.,2-/05//2258.32389425,2*110-04,'413024331151641165/,75:9:18;63*8935:6277933;)-6484'*220-831*60734:9062&9:38405170-55*592667-9:86-6/010&525344/122*4/3464152426)0//371688276/6487045:83-67222.,)/*./1/6/20,-26,25110:218.,984:71::::758/7638078:0194823725,8:;58.:6;560;307662.52-333+-7)//./)2.--,230*,04,.32112--(.11$)/*,'*-).-+,-5'101,+534/1021)..*+(,*)%*/*,/0).--.,$,,/),*,--0)*+.%)+0..(-*-,-.-,.42776:53/33213684210%*-475,66665699:/+035/3020/+-*1257.87497/89478;7283-931.6653,///83.98;698)6.6783/70.465996/86598/')+970.22/721-340179994794590481166&-5-154:6693951.325::7+-546:5989:97)5.56+.529.78529;79.72865941873:554555:95;88;669559:914'0&347-49197:95865204/45-64.23104.20,36252714*1,-(/.26601526/20.--5650247859440325344/544620011%,.54/&17423.6217+46'.,395849:305:85025326341415/1-32-752536/3323&428.532-.-12032/'292)8//3/)11&.-4200+/34055204/564124,05402(5020*250.)31/13-0-4/3/12+61/40.&.54)0.-01%33614-125321256245331,-$,120).,/950348847544/045)68469876530'321.131313./6-6755..335,1001111101%)./0/.+*-(1//1,/.1.(110.0-305111+056646*.'+-*.-..4--/3/-'00,&-00+1.0+1/%2023.*05).,0045.&+201(021625601314414/322-5520-2030462*340+./#15366054./460.+5/2-121540355)12545455./016.605253333)46/42213421121+&#)363412/'%332144*-44%-25/02244544325'4215.,2-03/024/$-452%4425.54/1603666.562.'415//.1/104,/5154101/353.*13.3/2(/.11/$44-16/0143,'+,.)1.65216/05552310.02(1*)24/1-53,262*0+4045-*.-'01%100*44/244334)4155121/13456161315556/%*2216356,+(-22.2.-/(00+5%/+,/0#540-2-5463+04/--.161255+0'2.+)///(,445406213+42564433)1 @rCer/581/25_1721_CCS ATGGGGGGCCGCGCGCGCGCGCGCTCCGAGGCTGCGGAACGGTGGCGCGGCTGTCTAGAAACCGCGGCGTCGGCGGGCAGGGGCTGCTGGCCAGAGTGGCAGGGGCGGAGGCGGTGGCTCGGCCATCTCCAGGGCTGCCACGCAGAGCGCGGGCTTCGTGGCATGGACATACCTGTTTGTTTCTAACGTGGCTGTAGTTGGCATTCTATCCCATACCAAGATACCTTTTGAGACTAAAAGTGAATCAGAAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGTGAACCATAAAAGAGAACCAGTTTCCTCTCTACTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGGTTTCTCTTGTCACCCAGGAGTACAGTGACAAGATCATTGCTCCCACAGCCTTGAACTCCTGGGCTCCAGGGATCCTCCCACCTCAGCCTCTGGAGTAGCTGGGACTACAGGCCTGTGCCATCACAGTCAGCTAATTGGGGCATGAGATTTCCCTGCATTAGAAGGTTGTTGAGACCTGAAGCCTGGGAAGGTGTATTGAAAACTATACAGGAGCTCGTTGTGAAGAGGTTTTTCTCCCAAGCTCCAGCATCCAAACTAAAAATAACCTGTTTGAAGCTTTCATGGCGTTGGCAGTCCTAATAACACTTATCATTGGAGCCTTCTACTTCCTTTGCAGTGTCAGGAAGGGCCACTTTCAGAGAGCCAGTTCAGTCCAGTATGATGTCAGCCTGGTAGAGACGAGCAGTACCAGTGCCCACCACAGTCATGGAGAACACTGAAGAAACGTCAAAGTGAACCAAATCATTGCTTTTATTTTACAAAGGCAGAAATGAAACACCACTAGGATTTCATTAAGCCAACTCATACCCAGTTTCTACAAATGAAAATCAAAGTCAATCATCTAAAATTTCATGATTCTTCCCATCAAGAGGATCTGGAGTCTTCTGTTCCCATTAAAACTGAATTTATGGCAGTGCAAGCCCGGGCCAGACTGGGTAAAAAATGATGGAAGCACATTTATATTCTTAAAAATGTCTGCAGATTGCATAGAAAGTTCTCAGATTTGTAAAAGTGTATTTCTATTGTAATTCTTTGCATGTTCATTTTGTTAAATTTGCAATATAAACCAGTTGCACATCTTTTGCTATCTGGCCTCCTAGGTTGAGGGTTAGGGTTTGCTTTAAGCAAAACTGAGATAACTATAATGTGAACTGGCCTACTGGATTGCCCACTTTTATCAATCTGCAAGGGTGGATCTATTTCTAGGTCTTAATTTCAAGGTTTACTTTCCCTTTTCCTTAGATTTTACTTGGATCAAAGGGCATGGAAATATATTTCTTCCTTAAGTCTTATACAAAGGAAACTGTGGCCCCAGAAATTATTTTGCTTTGAAAGTATGTAGATGAAATAAGTATTTTAAATGTCTTGATTAAATAAAGCATTCTATGATCTGATTGTCAGCTCAGTATGTAGGCTAAGGGTATACCTTTACTTCTCTTTTTATGCTCAAATTTTTTTCATGTGATTGTTATTTTCATTTCACCGAGGACTACAATGATTGTCATCTCTAGGAATTTAGTTTGTTTTTAGCTAATACTCCTTTAATGCTTCTAAGACAAGCCTTTCAAAATTGTAATAATGAGTT + +2)5553+.221(+11)-+1-3-*$(/1-(1/03326+13+4-'1-12/6.25//4/$,04134+/5/121435+44360636523+/-6&.1,30#%5'/$0/0+,4)*31-6/-6//506*54515/1//66545141+&1,**-0-1(335:;5:657342.:8-875+32789:305/5:17.335<:,3281487<;:1:89802>:5.8=?-5/744+;89?:>>71:.*99;9710>>?9=.=<101(/34,523948;875<99=>.<*;92,><:;8=>5?383<<4..7718::<9:;3<349?:91;<80/538+:98+;;4=6<49::4/216::>+37<==:7&56;8/9=8-25499>9<<<0:>98854?19?;>>:?>7+2-8778=<9:3929:=866498=:749;+)$77'++55<05618=<=?65:<9:497'=6:<2=92=9966+7=89;1579932*569<,:9:6-*:@:@)A>5=BA=@:>??*=69=?577=8(16'226789-7:<:=.94@6-@:91624:;257698#56.7,9/758=C;&78862304453696467:5;:8;7=58/.(;959:92:=77542/14813.:?2><;)%:=?;9767<;<->=>.678(1,2858;:67;;;3747;66,412<:876:977?5748;.2;.,782210,2&.+1*-54587559/7-*947;6-@>B>:@?47@?AB?C>?@;7D:B=:68;@;FB365;<=G@:E==@=84<9EC5C?<2>A?6@EGCE2@:=-4:84=7<<@;FDCCC@:BEC<>12:E3;=>C>BEA;6DEE@5@@?CF3FF1>66<$9087'87>9:<;>3<6><'@@;=:?$93/A;6@:5505&9873.=<:D@<6?A@9;A@C>@):<<>@7@@797:?;@??3==@=;@5$<,19*7:,7@0?C?,@=99:8A<<=A4?57;:A*A<6;:6A@:?@>@B+1*2449@2<=:7&92-4;9?;8?;5?BB&1,,'05>90178:4:+>>>BB?@G>D:6=?>=E.BB;?4939;<;7A@8?AF?CEF/A>@9?::71:2398AB3@=>?1=557B?<443;A=8>7B:35??8<39;@@B8CB@<+3-686?@;>37:61.9=;AB;7===@?A8A8@CAAA8B?9;;=6;?49;=3?6+;>6?>BA(0;:AA?=@CA@?9@@7@7?5=C;99@>@:B49=9-9<::/@>><@A.A?@<5<6>1@@>0<9?BC=4ABB?>A9BB>B8?=>C;9@>B;CBC9=@+B@?;>6>4>@6?009<0@?;=4B?:73,0;%>7;>==A?.;98@CA=A7?8@)<;4<5*355A@::6A@-,>84>$:;@-78><53.4><5<18;505=7453/894<<;6437414;:59<32:4<51<96:2;23)8.;63<82.9*63;;2))).$&===:AAB@>4>9%9<;9??979<=).4;>7<<(>?:9<8CC@<,:<41<@<1<7;8?4<67?;<6605946=7>-374>B?:7>:@;8::9:88'2/7;;&6765<>-:<3&;2:87@A @rCer/584/25_1997_CCS ATGGGGACGCGCAGCCGGGACCGGGGCGGGGCCGCGGCACTGCGGTGAAAGCCGAGGCAGCGGGCAGACGAGCAGGGGGCGGGCGGACATCTTGGGATCCGGAGAGTGGCCGGGCCGGCAGAGAAGGGGCCTCGGGACACCAGGTCTGTTCTCAGAGCAATGGGCCGCGGAGACTGATCTGCCGCCATGATTGGAGGCTTATTCATCTATAATCACAAGGGGAGGTGCTCATCTCTCGAGTCTACCGAGATGACATCGGGAGGAACGCAGTGGATGCCTTTCGGGTCAATGTTATCCATGCCCGGCAGCAGGTGCGCAGCCCCGTCACCAACATTGCTCGCACCAGCTTCTTCCACGTTAAGCGGTCCAACATTTGGCTGGCAGCAGTCACCAAGCAGAATGTCAACGCTGCCATGGTCTTTCGAATTCCTCTATAAGATGTGTGACGTGATGGCTGCCTACTTTGGCAAGATCAGCGAGGAAAACATCAAGAACAATTTTGTACTCATATATGAGCTGCTGGATGAGATTCTAGACTTTGGCTATCCACAGAATTCCGAGACAGGCGCGCTGAAAACCTTCATCACGCAGCAGGGCATCAAGAGTCAGCATCAGACAAAAGAAGAGCAGTCACAGATCACCAGCCAGGTGACTGGGCAGATTGGCTGGCGGCGAGAGGGTATCAAGTATCGCCGGAATGAGCTCTTCCTGGATGTGCTGGAGAGTGTGAACCTGCTCATGTCCCCACAAGGGCAGGTGCTGAGTGCCCATGTGTCGGGCCGGGTGGTGATGAAGAGCTACCTGAGTGGCATGCCTGAATGCAAGTTTGGGATGAATGACAAGATTGTTATTGAAAAGCAGGGCAAAGGCACAGCTGATGAAACAAGCAAGAGTGGGAAGCAATCAATTGCCATTGATGACTGCACCTTCCACCAGTGTGTACGACTCAGCAAGTTTGACTCTGAACGCAGCATCAGCTTTATCCCACCAGATGGAGAGTTTGAGCTTATGAGGTATCGCACAACCAAGGACATCATCCTTCCCTTCCGGGTGATCCCGCTAGTGCGAGAAGTGGGACGCACCAAACTGGAGGTCAAGGTGGTCATCAAGTCCAACTTTAAACCCTCACTCCTGGCTCAGAAGATTGAGGTGAGGATCCCAACCCCACTGAACACAAGTGGGGTGCAGGTGATCTGCATGAAGGGGAAGGCCAAGTACAAGGCCAGCGAGAATGCCATCGTGTGGAAGATCAAGCGCATGGCAGGCATGAAGGAATCGCAGATCAGCGCAGAGATTGAGCTTCTGCCTACCAACGACAAGAAGAAATGGGCTCGACCCCCCATTTCCATGAACTTTGAGGTGCCATTTGCGCCCTCTGGCCTCAAGGTGCGCTACTTGAAGGTATTTGAACCGAAGCTGAACTACAGCGACCATGATGTCATCAAAATGGGTGCGCTACATTGGCCGCAGCGGCATTTATGAAACTCGCTGCTAGCTGCCACTAGGCAGCTAGCCCACCTCCCCACCCACCCTCTTCAACAGGTCCAGGTGCCGCTCCCTCTCCCACCACACATCAGTGTCTCCTCCCTCCTGCTTTGCTGCCTTCCCTTTGCACCAGCCCCTGAGTCTAGGTCTGGGCCAAGCACATTGCAAGTGGGACTGGTGGAGTAGCCCCTGGGCTCCCTGGACAGGGAAGTTCTGAGGCTCCTGCTCTCCCCTCCACCTGTCTGTCCTGGCCTAGTGCCAGGCTCTGAGTTCTGTGACCAAAGCCAGGTGGGTTCCCTTTCCTTCCCACGCCTGTGGCCGCACCTCTGGAGTGGGAGGGTCGGTTGCACCCCTCACCTCAGAGCTCTCCCAAAGGCCAGTAACGGATCCCCAGCCCTCAGTCCCTAGTCTGCTTTGGGATAGTGTGAGCTTCATTTTGTACACGTGTGACTTCGTCCAGTTATAAACCCAATAAACTCTGTAGAGT + KHAJKKJKEJDIKJJKGKKJHK@KJJK3KKIAKIIDHKEJKKIKKIIDKKKJKKJ?KKGKK8KKJFKKKKHJKK9KKKKK?KAEBKKKKKKDKFKKKG9KKKKKKKKHKHKKKKJKDKKKKJKFKGKKKJKKKHKKKKIHKFIKIKKKBKKKHHKKKKKKKKKKJKJKGKEFIKKIJGJIJFKJHKKEKI8KHKK?IIKKKIKJKJGKKKIKHEKJ=K)KJHHKKKKHKKKJKKJJIKHIJKKKKKKHJKKKJKKKK+KKA>JJKKKJFJICKD7KKK3KKJFKKKJIK?KJJKH8KJJKCKI@KKHCKKKJ@JKIGKHKKKKICCKKKBKKKJKKIHKKKKKKKKKFKKKKKKKKKKKEKKHHJC=FCGIH@KKFKJKAKJFFFGKKBKJK?KGIKJKKKKH:BKKJIJHHJJKKKIK+KKJKHKJKKKKKKIKDJKJEI9KJDIJIKKJK?KJKJCKIJJCKKAKKAKKJJKKGKKJJK+KKKKI?H6KJIKK@J?KKKIJCKKIKJIKKJKFAKJKGHHKKKJIKA4JJJKAHKJKKKKKKJK@KHJJKEK?JJKJBH@KK4JGGJICEH:KJKKKFKIEIIHHIJHJHD=GJF@E<DEJHDKKKKEKKDJKJKHIIIKKGKI>KKADJJJHKKKHKC@IKKIKKKKKKKJH?HGAJKKKKKKKIKIKHKCH=GKKIHKJKFKKCIDI;IIEG=D7JIJJKJHGKBKJHKKFF>HFHJH@IKJDKKKKIKKDJCIGKHJJJKJKHJKEKJCGKGJGJKIBKKIJKIJJJIGKIEKBJHDHKKKJEJBKJKKKIKIKKGKKHK.KKHHIJB?KKKKKKKK=KHI>;JKHKIKJHIKIGHJK@KJ=K7HI:,KJC9KJKJJKKGIK=KKJIJJHKKG5KJKG;HKJJJHK0JDADDKJKKKKIEKHJFDDKGKJJJKKJKA;AKKA?J6KKKKKJKKKKKDKK?KHKI>9@JKIIGJH9IAKJKIKE?KKKK>KGDGKKJJ?KK1H@CIHIHKEDKJKEIKDE7JKKKKKJKJKIKGI1KKKFKKKKKHKHKKHK>KKDKJKKHIIKHKIJ=@KKKCAJKHKBGDDEK@=IHJKGGFCCKGJKKKKJ=IDJHKFJJKKIKKJK5KKJJKKIKJAKG.DEJH3KJGKKKGKKKJ=JKKIDIKFK.FJDKHKIJKKKK4KE@5IFH@BG?KJKJ;IKKKDHBKKHJJIFJJKJKKKBKKIKEIHKKJJKKKKKBKKJKHHKKKJIKCHKJKKIFCKKKJKKFKKGJJFKIE&HBKIKJI:JK@F@JIKJKJKGKJK@CJKKKKKKHIJJ8GJ-I;1BE4CIG=EFF?GJKIE @rCer/585/25_1444_CCS ATGGGGGGGCCGCGCGCGCACGGGACCCGGAGCCGAGGGCCATTGAGTGGCGATGGCGGCGACGGCGAGTGCCGGGGCCGGCGGGATGGACGGGAAGCCCCGTACCTCCCCTAAGTCCATCAAGTTCCTGTTTGGGGGCCTGGCCGGGATGGGAGCTACAGTTTTTGTCCAGCCCCTGGACCTGGTGAAGAACCGGATGCAGCTGAGTGGGGAAGGGGCCAAGACTCGAGAGTACAAAACCAGCTTCCATGCCCTCACCAGTATCCTGAAGGCAGAAGGCCTGAGGGGCATTTACACCGGGCTGTCGGCTGGCCTGCTGCGCCAGGCCACCTACACCACTACCCGCCTTGGCATCTATACCGTGTTGTTTGAGCGCTTGACTGGGGCTGATGGTACTCCCCCTGGCTTTCTGCTGAAGGCTCTGATTGGCATGACGGCAGGTGCCACTGGTGCCTTTGTGGGAACACCAGCTGAAGTGGCTCTTATCCGCATGACTGCGGATGGCCGGCTTCCAGCTGACCAGCGCCGTGGCTACAAAAATGTGTTTAATGCCCTGATTCGGATCACCCGGGAAGAGGGAGTCCTCACCCTGTGGCGGGCTGCATCCCTACCATGGCTCGGGCCGTCGTCGTCAATGCTGCCCAGCTGGCCTCCTACTCCCAATCCAAGCAGTTCTTGCTGGACTCAGGCTACTTCTCTGACAACATCTTGTGCCACTTCTGTGCCAGCATGATAAGCGGTCTTGTCACCACTGCTGCCTCCATGCCTGTGGATATTGCCAAGACCCGAATCCAGAACATGCGGATGATTGATGGGAAGCCGGAATACAAGAATGGACTGGATGTCCTGTTCAAGGTTGTCCGCTACGAGGGCTTCTTCAGCCTGTGGAAGGGCTTCACACCGTACTATGCCCGCCTGGGTCCCCACACCGTCCTCACCTTCATCTTCTTGGAGCAGATGAACAAGGCCTACAGGCGTCTCTTCCTCAGTGGCTGAAGCGGCCGGGGGCTCCCACTTGCCTGCTGCATCTATGGCCACTGCGCCCTGGGGCCTGGGCTCTGCTGCCCTGGACCCCTCTATTTATTTCCCTTCCACAGTGTGGTTTCTTCCTCTGCGGTAAAGGACTTGGTCTGTTCTACCCCCTGCTCCAGCTTGCCCTGCTCATCCTGATCCTGTGATTTCTCTGTCCCTGGCTATTCTTGCAGGGAGCTGGAAAACTTCCTGAGGATTTCTGGCCTCCCCTGGGTTTTAGTTTCAGGGCACACAGGACAGCAGAAGATCCCCCTTCTCATTGGGGAAACCAAGGCAGAACTGAGGGGATAGGGAGGAGCAGAAGCCATCAAGATGGTCAAAGGACCTACAGAGGGAGATGTGGCCCTTCCTCCCCTCACTGAGGACTTAATAAATCGGATTGATGAT + KK*KKKKKIFDKJHKKKKKKKJKKK-KKJKKKJKKG;KKDKIFKFGKJJKKIKKKKKJKKKKKKKKKKKKKDK#KKKFKKKK-KKKKDKKK6KKGKK>KKKKJ?DKK%KKKIHJKKGKKKK3KKKKBKHCKEKDKKKK@KKKKKKKKJK8KKKKKKKKKCAKKKD@KKKKHKKKKHKJBK>KCKJKKKKKKKKKJG3KKKHKBKKKDKKKKKKKKKKKKKHDK5KKKJKK>FHKKKKKK>KKKFKIKKIKJKJKKK7KKKKKKDK?KKKKKK8KKKHK1KKKKKHKGKKKDKCKKKJKKKEKKKG>KKKJKJJKFKKKKKKKK7KH@JKGKKKGK?K5KJIKKHKJIHKKKKJKKBJKKKJKKKKKKKKI1KKKCKKIIIKHKIK+KKKKKJKK1KKKFKKKKKKKKKKKCKH;KKKKJGJJKKKKJ2KKKJKKKFKKKKJK?KKKK=KK=KIJJKEJKKKKKIKKKFIH@JKK;KKKKJKKKKKKKKKJHK6KDKJIKKKKK>KKKHKKKKKJKKBHKKKJK*KKKKKKKJGKKHKJJ@KKKKKKKKHKIIKKEKK;KKJKKKCKKKKKDKKKK2KKKKI>KK'KKKGKKKKJKKKKKKKK?KKKKEKKKKKJKKFJKHKKKKKKKKJKKKJKK>K6KK@KJJJKJKKGKKJK>KKKKKIKKFKKKHJKJJKKKKKJKKKKKKKKKKJKCKJEK9&KKKJ?KJKAKKKKKKKKJKKKKKG?KKKKKKKDDKKKKKKKJIKKKKK@KKJKKKKJKJKJGKJJIDKKKKIKKJIKKKKKKIKJJKKBKKKKKJKIKK;KKKKKK9KKKGKKJCKKJ2KK:KKJKKKKKKKKKJKK>KKJGK@KKJKKKKKK?KKKKKKJKKKKKGKKKKKJ4KKKKIKKJKKKKHKKKK&KKKKEKKKKKKK2KKK-KKGKGKEKKKKGKKKBHCKKKKKF-KKJ>K.GKJKAKKKKJKKIKKKKKKKK-KK9KAJKJKKBKKKKKKKJFKCID*KJ8BKGIHGBFIJH2KKKK,K3KJIAKK3KJKJ:KJ%KGBJKJJKJ8IK>7KKJKK;JK=>2KGHGKJIJI@J5+DEBIDKKIKKJKKKKIKKKKKAKK3KJKAKKKJ7IJKKK>KFKCKHK5HKFKH+KKKKKKKJHK'KKKJ>IG3KK@DAA)IFKDIKKKJH6KJGJ-DKHH5HJD5H='FA24D?II,DI#BADHI.H@?K?JFK3JKEKKIKJG>F%JJKJJKKJ9KGKKGCBJJ8KJGFF1JJDIKKJIE0CKKK@JFKH*JJIIJKJHDFHF3EHGEIBFHI+DBJGK,KJJKFIFHK;KH?7JIKJKK0I?E0HIEJAKIJIIHHFKJII9A?GKJGJKJJFF:KJJG)D:GFB&GFFHHIJGGHDDG*;FKCI(IHGJJK1C2FAEK9G9K?K6KJJDIJIKJIBJI)JKJ@IJ@FIJ2JKHCEEAKGKKDKIJ(GJFGG9KAKKJHI.@FK(KJ<>JKCKK=EB@@JJKCKKECHH?)*?GJG%FKKJD9ID5KKGKK>KKIJ1KKKKH?G-JK'BKKKFKKFKKKJKKKKKJKJIKKJKKJKKKKKKKBKKFHJKKJKKKIKKEEKJKKKKBKKKJJKHGHBIKKKKJK7KKKJJKKK=KHHBHK4KGK;KHKKKKKEKKAKKKKKGKJKKIKKCJK?K1KKJCKJKGGKJJJKFKKKG7KJJKJJJIHJIJJKKJJHJKKEJ6JFHGKKDKIGK:HKKKAJKK2KKKKKJKIKKKKHDKKKKKJKKDKKHKK=KHKKHKKKKKKKK?KKKKKBKKJJJ5KFKKKKGK%KIKFKFKGKKKEKK;KKKKH7KKKKHKKJJKK@KI5KKKI?KKKKKEKAKGKKIKKKKKKKKJCKHIGIGJKHK-KKIKKAKKIGKKFI(JIKKKJJIKIKCKKIJHIJ?K;K?KKKKHJGKKHIKD@KKKJKJKKJJFKJKKJJKKJKF7BKHK8KKJKGKF2D0J@9BKHIKKKK=KKK=KIHKKGKKKKKKKDKKKKJKBJKKKKJJK:KKKJBKKDKJI=JKI4KKKKKKKKEKKKI=KKKBJ)DIKKKKKKKIKK6KKKKIKKKKKJKKHKKKKKJCKF8FFCH?0B1JEGIIJK8KKII,@EFK=IKKKKKIK)KJHHAKKKDJJJJKDKBIE5J(IEKBKK??KKKJ:KKIKKKJKIIKK1KKKKIKK?KKIIKKKIH=KBKKKKKKKCDIKKKJKKAKIGG=KJKI@#KHKJAKJJ;F@4KJIF@BH-=B@GFKKJIKJKKBJHKKEKKCJ@JGHJKEKHIG.&HKKKKJKJ5KKK4KKJKIKKK(JDEE0JI@HKIAKKGKHE5JJI6BJJKIEKKKKJKJHJ @rCer/591/2356_80_CCS GGCAGACTCTCACCGCGGCGGTCGTGAACGCTAGCCGTTCACGCGTTCGGTCCTCCTTGGCTGACTCGCCGCCCTAGCCGCCGCACCATGGACGCCCCAAGGCAGGTGGTCAACTTTGGGCCTGGTCCTGCCAAGCTGCCGCACTCAGTGTTGTTAGAGATGCAAAAGGAGTTATTAGACTACAAAGGAATTGGCATTAGTGTTCTTTGAAATGAGTCACAGGTCATCAGATTTTGCCAAGATTATTAACAATACAGAGACTCTTGTGCGGGAATTGCTAGCCGTTCCAGACAACTATAAAGGTGATTTTTTTGCAAGGAGGTGGGTCTGGCCAGTTTGGTGCTGTCCCCTTAAACCTGATTGGCTTTGAAAGCAGGAAGATGTGCGGACTATGTGGTGACGGGAGCTTGGTCAGCTAAGGCCGCAGAAGAAGCCAAGAAGTTTGGGACTATAAAATAATCGTTCACCCTAAACTTGGGAGTTATACAAAAATTCCAGATCCAAGCACCTGGAACCTCAACCCGGATGCCTCCTATGTGTATTATTGTGCAAATGAGACAGTGCATGGTGTGGAGTTTTGACTTTATACCCCGATGTCAAGGGAGCAGTACTGGTTTGTGACATGTCCTCAAACTTCCTGTCCAAGCCAGTGGATGTTTTCCAAGTTTTGGTGTGATTTTTGCTGGTGCCCAGAAGAATGTTGGCTCTGCTGGGGTCACCGTGGTGATTGTCCGTGATGACCTGCTGGGGTTTGCCCTCCGAGAGTGCCCTTCCGGTCCTGGAATACAAGGTGCAGGCTGGAAACAGCTCCTTGTACAACACGCCTCCATGTTTTCAGCATCTACGTCATGGGCTTGGTCCTGGAGTGGATTAAAAAACAATGGAGGTGCGGCGGGCCATGGAGAAGCTTAGCTCCATCAAATCTCAAATGATTTATGAGATTATTGATAATTCTCAAGGATTCTACGTATGTCCAGTGGAGCCCCAAAATAGAAGCAAGATGAATATTCCATTCCGCATTGGCAATGCCAAAGGAGATGATGCTTTTAGAAAAAAAGATTTTCTTGATAAAGCTCTTGAACTCAATATGTTGTCCTTGAAAGGGCATAGGTCCGTGGAGGCATCCGGGCCTCTCTGTATAATGCTGTCACGATTGAAGATGTTCAGAAAGCTGGCCGCCTTCATGAAAAATTTTTTGGAGATGCATCAGCTATGAACACATCCTAACCAGGATATACTCTGCTCCTGAACAACATACAAAGTTTTAAAGTAACTTGCGGATGGCTATAAAGAGTTTAACAAACACAGTATTTTTTCTTAAATGAACATGTTTATTGTAGATTCTTCTTTTTTGAAAGAACAGCAAAACATCTACGGCTCTGTAAAGCTGGTGGGACCTAATGTTCACCTTAATTCTGACTTGAACTGGAAACATTTTAAGAAACCTTCTTGTTGCTTTTCTAACAAATTCCTGCTTATTTTGCCTTTGCTGCTGCTACTTTTTCTAGTTAGCTTTCAAACTTGCCTGTGGACTAATAATGCAAGTTGCAATTAATTATTTCTGGAGTCATGGGAACACACAGCATAGAGGGTAGGTGGGGCCTTCTAGGTGCTGAATCTAGACATCTGTGGGGTCTCCTGGGTTCAGCGGCTGTTGATTCAAGGTCAACATTGACCACGTGAAGGAGCGGTTTAAGAGTACCAGGCAAAGGGCAAACTGTAGATCGATCTTTATAACTGTTATCACAAGAGAAGTGACATACTTTATATATGTTTCTATTAGCAAGGTCTGTTTTCTAATACCATATACTTTATATCTCTATACATTTATATTTCTAATAATATGGTTATCACTGATACATGTAGACACTTTTTAGAATTTATTAAATCCTTTGACCTTGTGCATTATTCCATTAGCAAACAGTTGCACCCCTCCTCAGCCCTCCCCTTCCTCTTTTTAAGCTGTTTTATGAAAAAGATCTAGAAGTTCTTGATTCATTTTTTACTGTTTCTTTCCAGAGGGTAAAAGAGAAAGTTGATTGGTTGGTTGTTTTTTCAATTTATTGCCATTAAACTAAAACAATTTCTGTTAAAATTACCCTATCCTTTTGTTTCTCTTGATTCTGTTTTCTTTGTAATGTTTTTGGATGACAAAGAGTGATTACTTTACTATAGTATACTTGACTGATATAGTCTTTCCTCTAATTGTTTTATCTATTTGTCAAGTATTTTTAATGTTTAGTAAATGTAGAAACATTTAAATCCTAAAACAATCC + 0),,11-43-4.-*4/1/(1,,-.421,03,35*603/)13#(4.1,4///2(1.)515/3&/,-00.1.-340-*010123+3-4..453),*55545.54203-1/./.1015**)1%,145113.(02.5/...'2&--/--)224/1/35-43-13631536235522+04.12../*+,3-005)0*2-314/.20/60200&024-13401*.-.0+./3.2.4166646501-0110433631644/4410)20,33-0),,,.%,*51010.*,*.0+,,.-,/4**/1)0)$5344-4/1340&,/104),2-4.0*531105./033)1-..(%)$)(+),*-,'-*/./+-..0..(.*+(.(.-*1,/1.0.,0+'142532$1'*-,-.0*...3,303-0-,)/2406260465653-0012--,)/64-,)#-.-1.,.1'-$"*522$,,(0+/35))($,)).0-+,+*-+-..%2/-(',&+-)-+1012-,2,+*)(*,+&++%*)''-+(#)),./)/110-/0200/(..)&)1/.-/*/0,/.(0-*'/0+10100&,,-0/.+$'(('%+0++)10*+0(,,(-0+()(0,0+&///.-+0.$10-))/)1202.0'',),+.1-10.0.%'((-/'/*-(*+-/$1'''%-*.-+*%*+*,%+//-/.&0+021.00-1.010001+,-+&-11.,(%++0-',*002--+.1.*110.11.01.0,,)/0,&%()'-.+)'&)+)-,%%(+0&)+/,00,-1//-.-/002,+.,+/0',0*(+.,1..,-'*)-01.*0+0/0(/../%10/++&'(+111,/),.%//%*),0,02-/011,%/&(.+*0&.2-020-2/*./0,-))#,'+/.1+0,./.*&(-/+/*1-,0-+'/+(0/.+-,10(/+.+)*/-,.*,(&1.+&//*0-211.,/(&*&'+01101/10-&,0//,'-/0+011.0/1/-)-.+1./+,,210,(-,+*.,.+-,20.,)&*/&1).+,*-,(0,/./***+-0111'+.,,,%./+(&,,/,010.1.12.,,.&&(+,-.+010//(,*+#,-+1,0(-/00.1/+$.110000*',&-+.+.1001/(/)-0/*000,,&$*&.0&/0-+.&0-../&,('&$/,11+21-/*//202/00110%/)-/-11/(//,,-0,'-0/11/.),+0,-.-//,+),&-0,/--/0(,/,++0**.**--.1'1///%0+)*'*$'*+-,1(&.+*()++0/*0.-,%#+'/1/-0,100-',/0.)(,/%(*%+,20/+*///*,0.0/*0,,,..&,*.-01&.01*10-/'*--11-+*,/+0-&*0,-+-&/0)-/&-,+./)/1,00,,-)+.-*)*$-%0(0--*/21-+)0/1,/.(100.-&0.)-/$000+12112/1-(),)+*0-102-.,2/./)/**0..)%0,./)()(*%#!$%##,/0/'//,./-+(,1*..221-1,,/)-*+20/*#%((/*).,-,-0--00)/%++)$((&&//0.-//,.*-+,,01---+110-**,)0.#%"*'&/10*/0-,--'()**0-./+110-/*0,-+$$#&/-&,/0-/10/*2)10**1)/-+/(0.,.00-//,.''112/,1,1+#$*.212-+'0-+/0$0/(,1(/.)(+(--+*.,,10-/(*-.'1-,*01/.,-)/)$$1-(++)*,(,,&))'.)-,.,,&+./.*&'+'$$&./2.10100,002/-,*0/,--.&0./00+/&.,*'//1)&'',.+0.)/-1-*22/00//0)+,)0-10/1.1),011,-0/0*.*,-*/+/++.-.00/.&+1/+/,$+-,10')1--/$,0,(0'-,,,+*,)/++%+10/+/.(%,1/.)1.--,.&*/'*,)).0*++12+2/21.12..,-(-"')+0.*&-,0.+10-/,/**,0-0+-),.+()+*++)()*+#*+)%'*&,,*.00-,)&'#+)-.$()+11).0*100,*,0'(+($($)+++$*)#%+&-&#)++-/*0+)/*(*-%&,$-+.*//-.(++#0/,/)&%'&.)')*$+-/)--,-&'$$!)(/020*(/,$,*+--*'%%'%'%-'--'###%$)'%()&+%#%#"""#""""""##%###&$""##"""$%%%#$#!!#""$%$#%%#%"&''$$"'&'#"%$%%%$%"""#$"!!"&#'$%$%"&%#$#$'$##%&$""""'('%$%#$$# @rCer/593/25_1908_CCS ATGGGGGGGGCGAAGAGGGGCGCAAGCTCACTGCGTTTTGAGTCTCGGGACCCCTGTCGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAACAACACCGAGAGCATCCTAATGTCCTATGATCATGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACCGTCTACCTTACCCCTTACCGGGTCATCTTTCTGTCCAAGGGCAAGGATGCCATGCAGTCCTTCATGATGCCGTTTTATCTCATGAAAGACTGTGAGATCAAGCAGCCCGTATTTGGTGCAAACTACATCAAGGGAACAGTGAAGGCGGAAGCAGGAGGTGGCTGGGAAGGCTCTGCTTCCTACAAGTTGACTTTCACGGCAGGGGGCGCCATTGAGTTTGGACAGCGGATGCTCCAGGTGGCATCTCAAGCCTCCAGAGGTGAAGCCCCCAATGGAGCCTATGGCTACTCTTACATGCCCAGCGGGGCCTATGTCTATCCCCCGCCAGTCGCCAATGGAATGTACCCTCCTGCCCTCCTGGCTACCCCTATCCACCGCCCCCGCCTGAGTTCTATCCAGGACCCCCCGTGATGGACGGGGCCATGGGATACGTGCAGCCCCCACCACCGCCCTATCCTGGGCCCATGGAACCTCCGGTCAGCGGCCCCGATGTCCCCTCCACTCCTGCAGCTGAAGCCAAAGGCCGCAGAAGCAGCCGCCAGCGCCTACTACAACCCAGGCAACCCTCACAACGTCTACATGCCCACGAGCCAGCCGCCACCACCTCCCTACTACCCACCGGAAGATAAGAAGACCCAGTAGGCCCTCCTGCCTCCCTGCCTCCCACCCTTATCTCTGTACCCTACCCCTCCCATTGGGGCTGCACTGGGGCTGGGGGAGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGGGACATTAGGGCCCCCGGCCTCAGGAGAGGTGCCGCCCAGCTTCCATGCCAGCCCAGAGCCCACAACGCTGCCCAGTGTGCCTCACTCACTGTCTGGGGCTCTCCTGGGAGCACGGGGCATCCCCTGTTCCTGTTTCACTCTCAGCTTCTCCCCTCGAAGGGACTCTCTGGCCACCTCCTCCACCGCAGTCCAGCTCCCTCAGTCTGGCAGCCACTGCTACACTCAGCCTCATGAGCCACTTCAGACCAGCCAGGTGTCTTCCCCGGCCCTGCCAGGCCCTGCTCACATTCCCTCCGCTGGTCTATGCTGGTCTCAGAAGGCCACTGTGTCTGCATTCCACTCAGCCAGGGTCCAGCTGCAGCCCTGCCACTGTCCTTCCCTTCCTTGTCCTGAGTCATGCTGTTGCCACCCCGTGTGACTTTTGAAGCTGTAAAATGAGCTTCCAGGGCTTGGGTGGCGTCTGGGCAGGGCCGCCGAGGCTGGGAGGAAGTGCTTCTGCCTTTCGCTGGTGTTTCTGGAATTTGCTTTCCCTCACCTCTCACTTCCCTCTAGAAGGAGCTTCCTGACTGGAACCAGAGAATGCATGTCTGTCCACTTTTTGGGCTGCTGGGTGGGGCTGGAAACAAGGGCCGCTGACCCTTCATGCCGGCCGGGACCTGCCACTAGCCCCCCAGCCTGCTTCTTCCCCTTAAGCTTCGTGCCCTGGATGCGCTAACATTCGCTCTTGTTTGTTCCTGGACTGGCCATGAAGTGAGGAGATGGTTATCTAAAGAGAATTCCCTATTTATTTGACAAAAAATCCAGTTAATATATTAATGTGAAATAAACCCTGTTTGCACCTTGATTTGTTTGCTGAAAATGTGAAATAGTAAAAATAAATAACTGGACC + ;@(>22=:4-9@7DAB9?B=D:A?=DB<<99>@66;.8;1=,0441:75:4;2<9@?8=;><<;@ADECEBF;C-57.26+:;?=92@:1=B=9BB?9:8==+A599<>A>3C@FBB:AAB2A8@:>B:G<5?;1<7:A>GE;,676A6A;7A;96<4>>1=74:;?=@;;7DA?:65?@-87305;>>>-<(36>>1<>AA>;?<7A?8E;E7CG9<;5AC=<<(902,A>?D?@BB93;FDD'26?A9C8:?(112AD@?B:?IADEBC6:>82A<==?3C:637>7D4=2-B5;<@JB=C5CBC7CE8D@=A:@:6;:?<=GAHA<>C;HF=5D5ABD?GBBF2GGEHEBEHD>3<;C*A9B3?@@:>B>B77B4HD8AAA;EG7EA1GGBC:=A2@5?AJDABBC6B5FB+A@F5DHBD9IBID695197+BB>AABB<5@:@EJBEHGI;=FB?F:@CFCA9FHFCEFHB,IGG?<C&C?CJDGBCBF@GGGHA?HBD>EFCG3@ABE@AA.6@BIG5@>?;8EF>D4=8.?>>;E<8C>CD@ED<:;>A;5E?A,@;DEED9FF/??.;:=A?6HCC?<&CFD=D4ECDHD>CFDEJFFGFC7F@:F98:6FECCBA5?A>E.=GHGBAEACHG9FF@<=>DG;CECE@G9?EFB@E@5=HCE>@G=DGDDHJE>BIIHGAF4E;EEAE@=G@EDE@EA4:E8BH?EABFHBIBAF3E8JCHB3<4EH<<;?FDIC>-GCD7DD@BC;BC5EA>(;AAB@C6C@EJG;>?AGD;GEHBEDCCIHFF>6<4AAEAFFG@GGBED<@71=-B?GBA7AEFC@EGCCJID?EGDB.@A?>CIF?H8BJ5FGB?CI:@E>?B3BC?:DB=C=CG@@>CE?;DEBCEIFBDGDF=IICFIG0@C@B:CFC6>=C>=AGFH;;AB>CCF9AEBG?GBEE=85D/9;=C>H;;=?D7>CFBH=@>DCAEC:>?EDE@DAH=3G:274AB::?*B;(?GE>3AAHA>=6>BGFDDAA@C9>;;=EB:<1DB:CEC>=>@;F@A7%8@6A=BCCD=:@=%11@:E8DAGF=9<699/>DEEDCFFJ>?DBF@=A0F::=DE8EBJHGFD=3ECEBH@?FE&E=F998E?E%DF@?5BG:A219?@BD6>->@<=E@A2@2;98<4EGCB?>?;BC=@BE?DF7BC@93@=B>@>>=7BB9==DAA98=F8EB>6,5CC???8C9D+=>7=/@560>?98<398>B@?>A=B;B4:27,4&9205;:=7>B@;;=6AA93<:>7686.?;7,426:=9-<6:17*)&4;342147==;93=<7053:667,9 @rCer/594/1987_66_CCS ATGGGGTGGCCGGGCCGGGCGGGGAGGCCGGTCCCCGCGGGCGGGGGCAGGGGCGGCTCCGCGGCTTCTCCCGCCGCCGCCGCCAAAGGGGAGTTTCCAGGAAGTGGCCATATTGGATCCATTCAGCCGCAGCCGCCCGGGCGGAGCGCGTCCCGCAGCCGGCTGGTCCCCGTCGCGGCCCCTGCGCTGGTCCCAGCCCGCCCGCCCGGTGCGGAGCTCGCCATGGCGGCCACCGACCTGGAGCGCTTCTCGAATGCAGAGCCAGAGCCCCGGAGCCTCTCCCTGGGCGGCCATGTGGGTTTTGACAGCCTCCCCGACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGGAGACTGGCATTGGCAAATCCACACTGATGAACACGCTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGAGATCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCCTGAAGTCCCTGGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATTATTCCCATCATCGCCAAGGCTGATACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCCACGGATGACGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGGCAGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCCTGGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGGAATTCCTGAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAACGCCGGGAACTGGAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTGAGGAAGGACAAGGACAAGAAGAACAGATCAGATATAGGAGCACACCAACCGGGCATGAGCCTCTCCAGCTCTAAAGGTGATGATGACCAAGGCCAGTGTGGAGCCCTTGAACTGCAGCAGCTGGTGGCCCGCCATACAGTGCTGCAGCTGCCTGGTCAGGGATGCGACGTGGAGGGAAGGATTCCTCTGAGGCAGCAGCTCCAACACATGGGGCCAGCTCAGGACCACCAGGGCATGGAACTGGAGACCATGGTTTTTAATGTTAGAACAGAAAACCCCATACTTTTTCATATATCAATGACCAGAAGCGCAAACAATTTGAATTTCCATCAGGGAACATCAAATGTTGCCCAACCCTTTTCATTCCTATCCATGGCTCCATAAGGGGCTTGAGGCTTAATGCCCACTCTGTGGCCAAGCTGAGCTTCCACCCAG + =7992+1423:66,?>;44D7@7+';5$7<<:2;92:=+5.<<@1>C6?AC=BB@:>B<=:2:1FDAD=7AD;>76>A8;@C>@99@:9)B69=<9.:0A@55==?7>=::%-69)9@B8==1;:=0:8C:97?.9;?1AA=?59?@/:;8%=3;>@0=?7A;1=:61?=.:>0929A569:B9E+:>>?A>7EB?>D8D?0;;E;D<2>?>?A=/;47>:5>5@?<482'=9;B;>:=9@:718=7034-;39;,>>=4907,;;A@=8<@65;:9<=A97:3/(5*>A;<4@AF-=>4?;:C95>8865<;B74,863149733:488:;7124/48<57/3<6:2:9:4548:13?9/18?<>1=6>=7:>939(<176853545:-5,8:6@A89<74796<;/165?4<.5484:96>:0(589A::;53*/,57956.8;17=>:;6?7(<;A;>8:26+=82*/6798B=<:.6<<+88132(86:<755+073789==::9=>57*8919:/599-4+3436262/-2;99;168:8;,;=9;/9/4)6,19466:96867335,8668/754732%533265:2/5951/4.)&.335,68886'5;974,91/%1..3*%.,0,907:7324973.,7229:,;96398;90775;33)30,18599%-554<1*354/2:25<94428:465-1.-60782548;1./564132>5:938:598-/5.915:2<79:4342468224+6;8,1<9:383..#.3=,;78:9869;6&789,2097.467653%:;41/126:766-7364/2026;2=:3(64/545=:7:936-::4068<1878037829:466304'2/=833<63>;<;6557;,;7867;66<:;93?>;<:>4<59=22=6;7==/:5:5/:>7=:;.666;09:>6..1)65578991;47020-;<::<9;<448>468;03:8968788226650;>:9.-,22,668/,3+7*9758.:37996:40;56:876:5>6/894.81<88.65>:9164)77693:829;.<9?)<>=8<8<5:;/3=8$98558<<2<:.91.10926:68;6687453)=659995665:36:6;=1-,':7?:?53873:;<723=@@:>977?7;>:>88+=6;/9.:8-7,7;0(346;;;;,96:755&26871676.099879552<=5;;;9;=7:31:3:-9501648366(&3*<::0856'0:71.23;4:966486931,4<78,7=:392852762/32-7:74:&86884<:*66;416;:577.4*;>=;8?:=465646/6/:==6=68:4<=<8384:635-/88<5<:4675=90.92.<5:><593=7=5509<:;7:8=89550;2;8511567:75>6;=265767:<8/=78:9238-723;98:+19<8:5:9-<7<8<>:8589:69>7=<5;;;8798206;<1?55:854;6715*;0-226277*875,693169.9:0:;7::=>3<0-4-)2776=3;=;=29676::93.374$.+(52/27:0>6308:0734.4-24'7<+69*<<,4<-:340*;<6-?9593<992<676873-<35:3885.3-:8<27/5=/83;67'<9:<674==0;=77:9.8969.-797/;7482<><873;7=;6958:8(9)2)*%:7 @rCer/596/1673_60_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTTC + :DEDAAB:7CHHFDCE=JE@HIBEEGGIIIIJDIIFFJJAHICDFHA?HICE6G;HCJI?GIIFJJ;I>E;CE;H9BGBFCA@BHHIFJAID@AHF>IBIHCIBBFED5C9D=AIECJCD@BBE<>G5HEJI@HHF@II:IB?EEH@FEF=?ICHGEHGFGHCGIHB@CFFC?GG=IHFG8I;DI?IJ3G@DFHID:;D;E6H:GFE/F@D7FHHG7%559IH@;EGE;G;JBEIHJF5HBCF@9J;E;?>CIJ@IFFFG=AJIFJGCC>,DBFII0FDHIDCIHCFHBBCG:AD>C9CEDCEAC,CA;*:?DGDCF:9:HGGHDCADE6DE=@AIEDEDE@2BD==EDC@?BA>A;7=AB;;AC9E3AFEF=:A0ACE?=*E@7C=EBCIBHFEEEC5CF@D(@BE>=>?>:'C8<><;CC@?=;'D>?BBB3ED?HJFDFDD@HEFFEIFGFBHCD??ECD@>D?DEHDBE=GHID@@=C>=>AIBHDCB8A?EFDFC9GCFA<026>.>>B@BCEG>FF@>A=BE9EAGGDFF6?AB/C@?6AFCEEA;<=?:ECGBCDDEC;D@CDGG@EF==AFACE?CE;?AB>EFDAF;A<@G@ECDDC3ED@D@EG2B5CEBBEA?@3;B@G@?FEDD@1EDBBA=>@D=@EEGC=3DE<@?CDGBD>FFC>AE=@;)=BEFAC<>E9DDBEA<>=ECABFBDD;2AD;CBBCBAEEFCCC=>3CAAABADA@AAB@99;=AC@=7CC6@CFB78<7B:@CBF@>;@>=>8B>?9DDAE6;F?G?7ACDAE7CEBGA6;C8+@2@B?<=EGBFCBA<;=@AACAAEA@<.?FEBA@=8>71,(,$/;@>B@C;DC=@AC>E???A=9?82>;<3EC8CDBBF@C9:9A:BB7=AEG?FCD?>EB;;@@CB7A>EAEA3F?AABEE=EF@>A=;@>0AA?,;?@7=@>1@>DE@G?C@@A4;D?<=;<;&68886>:?=@A?;>;A>=A?AB68AB:>?BC>CEDGFC;A*BEGEEFA3=FDE@>?EC?:BC?@E;EE?FEGFB>F@F:EC?E@DAEBEA3A>AED=CE?A@??AA;>.9E<<@;BEG=E=?>FEB=+E?FEFB>BBCD@=EF4@;FGFCEE0EF?C;5A@BA?C@A?DFB@CC:FDF>DCDEEDB>GG5FC7>B7FGDGE=GBFF:CDEF9>AE):GEEGBF @rCer/598/1887_60_CCS AAGCGCCGAGTTTCAGGGTTCCTGGAGCTACAGGCGGCGGGAGGGGCTGCAAATGCTTGACTCAGTGATGCAGAACCTTTCAGGGTTAGCTGGAAGCCACAGCCCAGCCTCTTGATGCAGCCTGGATCCAGCCGGTGTGAAGAGGAGACCCCTTCCCTCTTGTGGGGTTTGGATCCTGTGTTTCTAGCCTTTGCAAAACTCTACATCAGGGATATCCTGGACATGAAGGAGTCCCGCCAGGTGCCAGGTGTATTTTTGTATAATGGACATCCAATAAAACAGGTAGATGTCTTGGGAACCGTCGTTGGAGTGAGAGAAAGAGATGCTTTCTACAGTTATGGAGTGGATGACAGCACTGGAGTTATAAACTGCATCTGCTGGAAAAAGTTGAATACTGAGTCTGTGTCAGCTGCTCCAAGTGCAGCAAGAGAGCTCAGCTTAACCTCGCAACTTAAGAAGCTACAAGAGACCATTGAGCGGAGAACAAAGATAGAGATTGGGGACACGATCCGAGTCAGAGGCAGTATCCGTACATACAGAGAAGAGCGAGAGATTCATGCCACCGCTTACTATAAAGTGGACGACCCAGTGTGGAACTTCAAATGCAAGGATGCTTGAGCTGCCCACTATCTACAGGAAAATTTATGACCAGCCTTTTCGCAGCTCAGCCCTAGAGAAAGAAGAGGCACTAAGCAATCCAGGCGCCCTGGACCTCCCCAGTCTCACGAGTTTGCTGAGTGAAAAAGCCAAAGAATTCCTCATGGAGAACAGAGTGCAGAGCTTTTACCAGCAGGAGCTGGAAATGGTGGAGTCTTTGCTGTGCCTTGCCAATCAGCCTGTGATTCACAGTGCCTGCTCCAACCAAGTGAATTTTAAGAAGGACACCACTTCCAAGGCAATTCATAGTATATTTAAGAATGCTATACAACTGCTGCGGGAAAAAGGACTTGTTTTCCAGAAAGATGATGGTTTTGATAACCTGTACTATGTAACCAGAGAAGACAAAGACCTGCACAGAAAGATCCACCAGATCATTCAGCAGGACTGCCAGAAACCAATCACATGGAGAAGGGCTGTCACTTCCTGCACATCTTGGCCTGCGCTCGCCTGGCATTCCCCGGGCCTGAGTGAGGGCTGTGCTGCAGCAGGTTCTGGAGCTCCTGGAGGCCAGAGTGACATCGTCAGCACAATGGAGCACTACTACACGGCGTTCTGAGCAGAGACACGCAGCCAGCTGAGGAGGACAAAGATAAGGTGGCGTTCACTCCAGGCTCTGACTTTCAACATCATGCAGGGGCTTGTCTGTCTGGAGGCAGTTTGCTCATAATAACTATAAAATATGGTCATTTTGGGAATGGGATTTGGCATAAATGTGGTTGGCTGCCTTCTGTCTGCTGTGTCCTTGGGGTACAATGACTTTGATCTCAGCCATGACACAACAAGAAAACCCTCCCGGTTGACCTGGCTGGGCTGCGCGTTGTTTGCAGAGCAGAATGGGGAGGAAACAGTGTTGGCAGCTTAACTGATGTGTGTGGTTGGAGTCTCTACCATGGCAAAGGGACACCACAGGGTAGTGAACATTCAGGAACTGAAGGGCATATGGCCTGATCACACAGTTCCAAGCTTTTCAAAACTTCAGGTTATCAGAGACTTCCTGTGGGCCTCTCTTGATGGCTAAGAACCAGTTTTAGGGAGTAGTTCTCTCTGGATGGAGTGTCACTTGCTTACAGTTTCTGTGACTCAAGTACCAGCAGTGGGTTGAGACCTGGGTTGATGTTATTTACAAGCCTGCCCAGAGATGGGATAAACAGAGATCCACGGCATGAC + 1-2156213354.24560556414,214+1212,551264,-155,55305.,46345640656446356/2/0.6455/2566265201.6350065532124*/4641+4,/101435/145/-,&%+11+0/44101'0/53..+,,.*3.16/%.6+44355.46.532342)32.46'524+.*53*-0435.30--130145551//325-03*20442440-52455)562164666042,311211./%145132234/-2.0-632554(545-45301450315643(.)1.355/64,*,)),).32,522/3)1(.,3-,,,*0++2,.4210,+0///,.000120(/0-1/+/)(*/,,-,...'.)0222,*/&/0/0/----*0.%+10,.,(.-10/,,-)&-1/-11(+/(+*/,)/(0-,1202.10//0+01-2-'2*-01.*2.*0002-10/-.-/2,(,2.1//',-.&///,0&+11&0/..'0+---*/11-.+.(.,011021)1.(*)01.1,.0,/-11-,/.-1210/%/1+/.*/,2*,0('((*&+020+000.+&-1-+02110$(*021*$/0/'---//)0)1101.020*/,0-0//&01200/0'.2-***,,**$)()(,&/10/.10.*/./,'01-+22/01,..1*.-000--+-,12--2,0.22-.+&%&&+00,),-/+-*(..-(0+'+)*),/-0.-//&/2102/01,2.0/-/0,,,*()'***.,..---..,&'+'$('-,+-1,--)+,'00-0....*(-1/10,+,+*.)-),0-0&/+,+-&1),/,+01)1/.11*02//-/.21-*0&-(,-,,(---*.,+,)-,-+(--,,,(-,-(-)&)$,)+(+&*&,,,.,,-)-,+),,(,-)&+,-+(,(-+,,(---,()&,()$)'+-&-+-*.-,+&),--')...),-,-,.)()'(,,,))')'')*'(*+)-,)--*-++(-,,))),('$,++-(),(('+-*,*+(,+,+,,-+---$##(*#+))#+*,+((-,--.-..,,,,,+-)-+.*-,-+-+,(.,.,-)--++-,)+.-+#*-+)&#'+**-+.,(,-,*----(,(,),)-,,,(+''%'$($(%(+*-)%'+()-#'(,*%'--)--+*),-*,-*-.)-,+,)()*++-*)(&',+''-+,--+',-(,,,*--*+-&*+,--+)--),-*()(*',*-.+-&,.---.--,$#&#(($'&($'*))*$+,&,-+-*+--+,,-)',)-----,(+.,)''--,,-&&,)(--.,$+#+-----((,)()%&)'--+%&,%-,(,-(*-+'-,(,),+()(,-(-'-,----(,),,'(--+)),+*&*(-),+,'*+--*+,,,,,),),,&,+,-)-+,(+++,+,.--...+.**'&'&)).)(,-((.)-,,+%++',---.-,+*%,---,)--,.-,,)(#$,,..+,)-,-.+-,)),&)(%&,-),(&%(&&&'%*$-+-,,)'&#&'&*,-)+,,$)-(,+(-'+)+--(',,+(.'(,,)*')+*,----)(+&)&,+--+)&+--,++''&,)+(,*-'%,---),,,-((-,--.+,'(,,)---*#'),,,*,..,.+*(*',(----)+'-)&-,-,,)*((#&++$')),,))-------'-,(#),**),,-,,*+,(*---+,$),-,+),('(&+,,-,%,+(+&,+$&&((+&-,,+,','(*$*,'*-(,---*-*--+*,%---,--.-(#%*,)-,)(+-+.-*--(),+),( @rCer/600/25_2258_CCS ATGGGGGCGGCGGAGCGCGGCGCAGCGCCTGAGGCTTCAAGGAGCCAGGATCTCTGGTGACCGGAGTAGGACAAAATGGCGCTCGCATGGACTTCCGAGGCCGGGCCCAGTCGTGTGCTCTGAGGTTTTGGTTATGAACAGGATTCGGATTCACGTCCTGCCAACCAATCGGGGAGGATCACTCCAGTGCCCAGGTCTCAGGAACCTCTGTCTTGTGCATTCACTCATCGTCCATGCTCTCAGCCTCGTCTGGAGGGGCAGGAGTTTTGCATTAAGCATATCCTTGAAGACAAGAATGCACCCTTCAAGCAGTGTAGTTATATATCGACGAAGAATGGAAAAAGATGTCCCAGTGCTGCCCCAAAGCCAGAGAAGAAAGATGGGGTGTCCTTCTGTGCTGAACATGTCCGTAGGAATGCCCTGGCACTTCATGCTCAAATGAAGAAGACCAACCCAGGGCCTATGGTGAAACACTCCTGTGCCAGCTCAGCTCATATGCTAAGACAGAGCTGGGGTCTCAGACTCCAGAAAGTAGTCGCAGTGAAGCCAGCCGAATACTAGATGAAGACAGCTGGAGTGATGGGGAGCAGGAACCCATTACTGTGGATCAGACATGGAGAGGTGACCCTGACAGTGAAGCTGATAGCATAGACAGTGATCAAGAAGATCCCTTAAAACATGCTGGTGTCTACACGGCAGAAGAAGTGGCCCTGATTATGCGTGAGAAGCTAATTCGTTTGCAGTCTTTGTATATTGATCAGTTTAAACGACTTCAGCATCTGCTCAAGGAGAAGAAGCGCCGGTACTTACATAATCGCAAAGTGGAACATGAAGCTCTAGGCAGTAGTCTCCTGACTGGCCCAGAGGGACTTTTGGCCAAAGAACGAGAGAACTTAAAGCGATTAAAATGTCTGCGTCGATACCGCCAGCGCTATGGAGTGGAAGCCTTACTGCATAGGCAGTTGAAGGAACGGAGAATGCTGGCCACAGATGGTGCCGCCCAACAGGCCCATACCACTCGTTCAGTCAGAGGTGCTTGGCCTTTGTGGATGATGTTCGTTGTTCCAATCAGTCTCTTCCAATGACCAGACACTGCCTTACCCATATTTGTCAGGATACGAATCAGGTTCTCTTCAAGTGCTGCCAGGGATCTGAAGAGGTACCCTGCAACAAACCTGTTCCTGTAAGCCTCTCTGAGGATCCTGCTGCCCACTGCATTTCCAGTTGCCTCCTCAGATGTATAAGCCCGAGCAGGTACTGTCTGTGCCAGACGATCTGGAAGCCGGCCCCATGGATCTGTACTTGAGTGCTGCTGAGCTTCAGCCCACTGAGAGTTTACCTCTGGAGTTCAGTGATGACTTGGATGTTGTGGGTGATGGTATGCAGTGTCCTCCTTCACCTTTGCTTTTTGATCCTTCACTAACCCTTGAAGATCATTTAGTCAAAGAAATTGCTGAAGACCAGTGGATATTTTGGGCCAGATGCAGATGGCTGGAGATGGGTGCAGATCCCGGGATCTCGAAATTCTGAGAAAGCCTCTGCACCATTGTCTCAGAGTGGATTGGCTACTGCAAATGGGAAGCCAGAACCCACTTCTATTAGTTGATAGTTTGGGGAACCATTTTACTTTGGTGGATTTAAATTTCTCATTCTTCAAAGAAATATTTCTGATCATCTCTCACAAAACACAGGCAACCCAGACTATCTTGTTTTTCTTCTGGATTGAGTATTATAGTCAAAAGTAAAGCCAAATTTTGAGGACATGGACCAATACTTCTTAAGAGTTGTGGGTTTCTTCCCACTCAGGGCAAGGAAGAGAGATAATCCCTATCAAAGCTTCTGGGATTATTTGGTACTATACCTAAAAGGAAAGTGACATCTTTGTAATGGGATTTCCAAAGTCATGGATAGAAATCCACTTAAGTAGCTAGGTGGGAGCTGTCTTTGTGAGTAGTGTCTTTTAGATACTGATGGCCCTAATATCTGGTTATCTCTATCTAAAGACCTGCAGTTTAACTTTTCTTCACCTCTACTTAATTGGGCAATCTTTAACCTGTTTCCGTGGTGAACTCTGGCTTTTATCCTCTGAGAAAACAGCCCACAGGACTGGGTCCTCCTTATCCATCTTGCTTTTAACCTATGTAAATTTCTGTGGTTGCTATCTTATGTAAAATATAGTACAAATTTATTGTATATAGTTTCTATTAAATGTTAAAGAAAATGTTATGAAAAT + C;2CFBEBDIIDFFCDGD@BIHF@@C>AI?E96;>E9HGGHAGHIB>HFAGFI>HDIFIAF?;C>CGGI@FGDEJ>EAEEI?AE>7?AGGEGIADGHA;AHBEFGG=DHGB@=D@BD9FEEFE;HFI/IIFFFCDA>?FH0/4,+;=3:A@A?A?>?DEE@E+==A=?>:C<6DE@BADFC9*99;9AIF;F?;?BCDDB=E:?@EABH9FFFBEFIEC?F@?5=;D@44EC??=GF=FCD?FEJF:BF:EF3=?=6%?9>FIAFHD@=GHD>;8=G:@DFAGIFEB@HFHB7=.?DI3F==:F?A5EIHGBIFHDFEDF?CCAFC@EEFF>DDG>;6?;5E@GFC??<3A?HAFFEHFF>F==C<<<,>=>BD8@AA2937B9BF>=DFGB@=8=>=>DAAB@FD>;2E?CCG@7DF5@8?A:BADFF=>?5=1=@.=A<>C1=<>B>9BD@@?DFDFD?FEBF>=-?B89EBA)>?CCGEABE@9=@AA8;>6CDGE=;7@>EGF?DFD@@D@DAAA4DEI?EC?A>GAD@CDC5CGB;@@:=C@@DC4@.>>>BCIGE@JJE@D;FHFC6GB?,DAG+F<==BAC<4CCEC?AA@EBBAE-HFDEDB?C?AGGFAACD3A;4=?BD@?/:6=DA2:@D3EG?GCF>=C=CFCC1CAD@DEI0BE*:79:CAJD?DBF8D=8;>.@BCECI>DEF<>@A=@=?E>0>9?=>EDA@FEDE@@ICC@6=A::83EED9:CCAF>ADA?GCI7CE?D;=;@D)@(?C>@ABC7A>5<6*65:5;=AD=D>@C:>..%87:0?<5:?FGB@==4BACGEIBFE->90HIB@=7A?BCBDDF@?F@B:BD<5IGHAFEHGFEIIFE@4@@09>DA;6=07==85?@BA,;=DDCDEEFB4?E?;DEDEAGE7==AAC:=@:;AA8@668:698941=A>>H7:>A8:5ABF5-FGF6=9@AID?:?CC2=0<@:@E;567=?B6BDEI5D?=CD?JBA'B6C@2BE=92C=???F:HFGD?DC=8BC8GFEDD?AEB4C?CA>GE,>8<1;8;2.89;>?34@/=;4>;@=<4B>A?32==A:79+<9.<>7B@B:4=FA6;A<9B=BBAD(B@AA5*80;AG/:81@BE?;=7@A,;7==<99<@;0FF=8D@=/98;9:9688>/1:=A?CE+CA<53<8:';<=8?==@76@>=>+&/914B'?B>:B:B:8?=8166.,/6;570-$;97,767:.7<@>3995;&1-45B?75>:;57=;8;988=39B>/965?9@C>96<96>/7@6980=;0%7:87:68B5=>740<0A7(@=06;8CC@7;@C86>>:6>01:>1<<6:1-1<=C-ABCCFC=GG7>>A@FFE@FC?6<3A<@D=:@D23@B6;8DGGCCG>BE>CB/;+?CD;9/832:=:84?4A*>,*99:4:57/=?=>9&A@A;74B/B==93B3>=<;CD?2>?EAB=2?AFD @rCer/601/25_1560_CCS ATGGGGCTCACCTTCCTTCGCCTTCCTGTTCCTGGCAGTGCCGGGCTCCCCTAGTCTTCTCTATCTTGGGGCTGGTGCTGGCCCTGCCCACGCCTAGGGCTCCGGCGCGTCAAGGGCCTCAGCTGGGATTCCCGCGCCCCTCGAACGGCCACGAAACTCGGACATCTTTCCAGGAGCAGTGTGAGGAGGACAGAAACACCCACCAGGACTGCTCAAGCCGCCTGCCAACACTGCTGCCACCATGCCAAAGAGAAAGGCAAAAGGAGATGCTAAAGGTGATAAAGCAAAGGTGAAGGATGAGCCACAGAGGAGATCAGCGCGGTTATCTGCTAAACCAGCTCCTCCAAAACCAGAGCCCAGGCCTAAAAAGGCCTCTGCAAAGAAGGGAGAGAAGCTTCCCAAAGGGAGAAAGGGGAAAGCAGATGCTGGCAAGGATGGGAACAACCCTGCAAAAAACCGAGATGCCTCTACACTCCAGTCCCAGAAAGCAGAAGGCACTGGGGATGCCAAGTGAAATGTACATTTTTGATAGCTCTGTCTTATAGTGATTCTACTGTTTGAAATACTATTTTTTTAAATCAAGTTTTATAAAACCGTAGAATTTTGGCTCTCTTTTTTTAAGTTATGTTGTTAGCACATAGGACACTTCCTTGTTGTCTTTTGTGGAAAGGGCAAATACCACTAATAGGGTGTATCTCAGAAACTGAATTGAAATAGGGGAAAATAGGATTTTCTGTCCTGTTTGAAGATTATTCTTGATTCCCTTGATTCCCAGGAGAGATTCTCTGACATTCACATGTCAGCCACTTTGGCACAGAAGCCTTACAGTGTGGGGAACCAAAACTTCGTGTCTCCTCTTTCCCTGATGCCATCAGCATAGACTTGACTTCCTTAAACCAAGAGTCTTGATGTGGCCTTGGCAATCCTAAAATCAACTGTGTTAGGTAACAAAACTCAGGCTTTCTGTTGATAACATCGAGATGGTGTCACTCAAAAGAGCCAAGATTCCTGTTTTCAGTTTGTGGATCCATCCTGCTGGTTTTACTGTATTCCCTCCATGTCGAAGTGGGCCTGTGAAAAGCTCATACAGGCCTCATGTGAAGTGTCCACCCTTTCTGAAAATCTTTCTTGTTCAAAACAGCAACAACCTATGTTGTTAACTTTTACAGTGACTTTTAGAGGAGGGGAGTTTGGAAATTGTAAAATGTTATAGATTGTTGCCTATTTCCTGCTGAAAGTAAATGTTTTTAAAAAGTATCATATAAAGCTGAATACAAGTTAGTTTGGGGGGAGATCCTTTCCTACCCAAAGTCGTAAATATATTCTTTACTGCCTTGTAGAAATTTTATACTTTTGCCTTTCACATTTGTCTTTAGTCTGTCCTGAACTGATTTTTGTGAAAATTATGAGTTAGAAATTCAATTTAACATTTTTCATATTTCAAAGTGGTTGTCTCTGCACTATTTACTGAAAAGTTCATCCTTTCCCCAGTGATTTGTAACACTGCCTCTTTCATAAATTAAATTTTTGTGTAC + KKCKKKKKKKKKKKKKEKKKKKKKKKKKCKKKK2KKKKIKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKFKKDKGKKKKHKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKK3IKJKKIKKKKKJKKKKJKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKHKKKKGKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKIKKBKKKHKCCKJKKKKIKKKKKKKKIKKKKKKKKKKKKKKJKKKKKKKKKKKKKKGKKKKEKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKJKKKKKKJKKKKKK;KKKKKKKGKKKKKKKKKK4KKKKKKHKKKKKKGKKKKKKKKKKKKKKKKHKKKK=KK@KKKKKKKCKKKKKKKKKJKKKKKKKKKKKKHKJKKKKKKKKKKKKK)KKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKJKKKKKKKGKKJKKKKKKKKKKKKKGKKKGKKKK;KKKKKKKKKKKKKKKKKKKKKKKIKJKKKKKKKJIKJIKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKK8KKJK;KKKKKKKJKKKKDKKKKKKHKKKKJKKKKKKKKKKJKGKKKKKKKKKKKKKKK/KKKJKKKKKKKKKKKKJKKJJKKIFKKKKKKKKKKJKKKGKKKKKKKKKKKJKGJKKJKKFKKKKKKKHKKKK?KKKKKKKKFKKKIKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKJKIKKKKKKKJKKFKKKKKJKKKKKKHKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKIKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKBKKKKGKKKKKKGKKKKKKKKKKKKKKKKKKHKKKKKJKKKKKKKKKKKKKKKKKKKIKJKKKKKKKKKKJKKKKKKKKJKKKKKHKKKKKKKKKKKKKKKKKJKKKKKKKJKKKKKJKKKKFKKKKKJKKKKKFKKKKKKKKKJKKKJKHKKKKIKKKKKKEKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKK7KKKKJKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKHKK6KKKKKKKKKKKKKKKKKKGKKJKKKKKKK;KKKKKKKKKIKKKKKKKKKKKKKKKKKFKKKKKKKGKKKKJKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKIKKKKKKKKKKKKKKDKKKKKKKJKKKKKKJKKKKKHKKCKK?$KKKKKKKKKKKKKKKKJKKKJKKKKKKJKKKKKKKKKKKIKK;KKKKKKKIKKKKKJKKKKKKBKJKJKKKKKKKKKKKKKDKKKKKKKKKK @rCer/603/25_1714_CCS ATGGGGCCAGTATACATAGAGGGTCTGCTTCAAATCAAGGCAACTGGTGAAGGGCTCAGCATGTTGGCAGCAGTATCCAAGAGATTGAATCTATTTCCATTTTCCTCATCTAGGATAACAGCTGCTTGAAGCCAGGGCTCTTAGCCCTTTGCATTCCTCTTTAGAGAGGAAGCCACACTGCCTTTCTGTGTCTGGTTCAGAGCTCTTCCTTCTTGGCATGTTTTCTGGACTACATGCACATGGGCAGCTATTGATTAATCTGCAAAACCCAGTCACTTGCCTACCCATAATATCTGGGAAGGTGTGGTATTTGTTTTAAAGAAACGTTTCTTTGGGAGGGCAGTTTCTGTCTGGACTTTGAGGTGGACTTAGTTATCCCTACAGTTCTTTTAACTCACAGCTTTTAATAAAAGATGAAATCAGATATTGGTGCAGTTGGGTCACAATTCTTTAGGATGCTTCTACCCCAGGGCTGCTTCCTGTTCCTAGTCATGGTTTTCCAGTTTTAGTAGTGGAGTTTCTTGAGGCTAACTTAGAGAAATTTCTCACTGAAAACTTTAAGAGTTTATTGATACTTACTTGTTTTTTCAGTTAATCATTTACATCACCTTTCCTACTCTCTGGAATTTAAATTTATTTCTCTAGGCTGGTCCTGGAAGTTGATAACCTTTTGGCAAAGCTTAGATTTAGGAGAAGGCTTATGAGTCCCTGTCCAGAGGGTCTGTAGATTCTCTTTGCTTATGACTCTCTGCCTGCAGCCCTGGCAGACCATACTGTATGTCATGGATACCCAGTGGAAATATTACTGAGATGAAACACATTTCCCAGGGTATTTAAACTCTCACTCTGCCACCTTTCTAAGGGTGGGAGGCTGGCAGAGAGATGCTGCAATGCTTGATAATCATTTGGCCACACTGAAATTTCCAAAGGGAGCTCTTGCCGGTCTTAAAACCAAAACACCTGGACACTTAGAAAATTCCATGAATCTAGCACAAAATATCCATTCTTGCCCAAGTGTATCCCCTTTCTCTCCAGCTTAATCTTTTTTTTTTAAAGCCCAGGCCAAGGGTACTTTTAACTGGAAACCAGGGGAGGAGGGAAGAACACTAGCAGGGAGCTAAGAGGCAGGTTGCTGGGTAAGCCATCCTGCTCCTACCTGGTGCCTGTATCTGAATTGCTGAGTGCCGTGCGCCAGTGCCTTTCCTTCACCTGCAGATGGAGCCCATCTCTTTCCACCTGGGTGAGGAGACCCTCTGCTACTCCAGGGGTAAACTTTAAAGAAGGTGTCTTGAAGAGCCCAAAGGACACTCACATGCTAAGGTGTCCGTTTTATGCATCTTTAAAATATTTTATTTTAAGAAAAAAAATAGCCCTGCCCTGTCTTAGTGCCACTAATGGCCCAGTTCCATCCATTCTGAATGGAAAAGCAGAGACTGCCAGCACTTTCCTTGGTCTTCCCTTTGTCTTCCATGATGTGTTGTCCCCTCATTCCCTCCCATCCATTTCACTGTGTGTGGATGGATAGCAGAGGGTACCACGCAGTCCTTGAGGCAGTCCTGTGTGATTCCATCATCAGTTGTTTTTGTATTCTAACTATCCTTCCAAACCAGCAGATGTTTGGAAATTAGGGAAAAAATTAAATTCTCATCAATGGTTGCTGTTATAGTTAAATCAATAAAGATCTTGAAT 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;:.=;7777=7:>:;>;:;84;<28;>99=8&:1&3391><:?:97<<8-53<508>>152175<(6=6:54864778:;5=89?::<=-6;8<=/=>8*:9821:88340*$-538/656/79.8519:=??=5826)72>;57:9;2480177/73087:76<38603+986:27927283+/8&7468+:;89565<95<)7,:79<8=<;886>;>3/5731686;8.9876<5;75277;5/;880:)/43;66(=<=+69985<;9<<>6=:755:2.+355/31(34-1'41*.--3+2;=<339<77;9.>84<5=<1171*301.2248=5:=>7>:9:0899+;8:>4>6074818273;77/9<7967,13;-698098557;317*8664;3,6=:5215(5669238076:):89;59*4)=446618<67/33376:8..6/3451+32(+,775.-1.=;7360;3842;44./3/017;2572'2..375739=?/78:=:/712/2;.)790076431:3*:5558+.%//79:96996:597'61/27584/31/786;9+249564794:13/31*8869.37813*7432/3501316:;48)65&632:;904573,/.608612148338445387641326/6:9)92387/2$6,24-5--/0,1/6/4-47.5732777:/6454640(03425146/20:37:5897908929766859663:5*78:67464;:2.1553538965'/.-33442250,699:64;0986649584955:78,7.(386+9959;856:4808986;:93827:83::/5,04.21.4.4053104594:3440.49988/871416358,58(50.079444/25-7382851*,.25*03-71-80545564769414*4)$.0'47334$.3477::0,6,441$326&77635668:927025293./236063/,84-632-54863712312467;7///-/2;1;66238396=*=>89=;78.*9:7+8>=:61?>;94'$040/46.;9386467985958+':(&2099;487:188?8731.52=53879?<6=?=;:81326:9;<=65=7,615>?99>875%*'(661/777=;,<8816.9:7:+8551;7<<3858/)64;?=836<9'-3073-7:9465-747+97.944:7<>;>2/'358>09608546>;)6778:5;9985)581)83;18:%)3989=6<708/.45291-',4:<97<.:4=64=99<:+:6,7=34+*.03.%-6587<$<<<<9;0..76?9794;06:=<&21;7:9;>>:::>6=.55/5155;708?>;:.6::9;-1'5.+266-132225875854:08<28.:.96/$63:21;2482$%.>*5:178868:775>>:8<:%4,<3/-;13;:::69::;95-49>=6.:+56;98<0849914;:73;>>86858=?22>=9>:78;9:<;==0=9;/;6(66>>.73&5192468-77:*7;8>8=35;,5079656356/36007:94*<<2<02:;&34:9-':+6/.>=<>;9>8692?<@C6>=/<60>78@?E?552F>>GI65=<*62)97 @rCer/605/1982_64_CCS ATGGGGGAGGTGCACTGTGGGAAAGGGCTTGTCGCTGTGGTGTTTGCAGTTGGAGACTTGATTGTTGGTGACAGCGAAACAACGATAACAAAATGCCAGAGCGAGATAGTGAGCCGTTCTCCAACCCTTTGGCGCCCGATGGCCACGATGTGGATGATCCTCACTCCTTCCACCAATCAAAACTCACCAATGAAGACTTCAGGAAACTCTCATGACCCCCAGGGCTGCACCTACCTCTGCACCACCTTCTAAGTCACGTCACCATGAGAATGCCAAGGAGTACAATGAGGATGAAGACCCAGCTGCACGAAGGAGGAAAAAGAAAAGTTATTATGCCAGCTACGCCAACAAGAAATTGAGAGAGAGAGAGAGCTAGCAGAGAAGTACCGGGGATCGTGCCAAGGAACGTAGAGATGGAGTGAAACAAAGATTATGAAGAAACCGAGCTTATCAGCACCACAGCTAACTACAGGGCTGTTGGCCCCACTGCTGAGGCGGACAAATCAGCTGCAGAGAAGAGAAGACAGTTGATCCAGGAGTCCAAATTCTTGGGTGGTGACATGGAACACACCCATTTAGTAAAAGGCTTGGATTTTTGCTCTGCTTCAAAAGGTACGAGCTGAGATTGCCAGCAAAAGAGAAAGAGGAAGAGGAACTGATGGAAAAAGCCCCAGAAAGAAACCAAGAAAGATGAGGATCCTGAAAATAAAAATTGAATTTAAAACACGTCTGGGCCGCAATGTTTACCGAATGCTTTTTAAGAGCAAAGCATATGAGCGGAATGAGTTGTTCCTGCCAGCCGCATGGCCTATGTGGTAGACCTGGATGATGAATATGCTGACACAGATATCCCCACCACTCTTATCCGCAGCAAGGCTGATTGCCCCACCATGGAGGCCCAGACCACACTGACCACAAATGACATTGTCATTAGCAAGCTTACCCAGATCCTTTCATACCTGAGGCAGGGAACCCGTAACAAGAAGCTTAAGAAGAAGGATAAAGGGAAGCTAGAAGAGAAGAAACCTCCTGAGGCTGACATGAATATTTTTGAAGACATTGGGGATTACGTACCCTCCACAACCAAGACACCTCGGGACAAGGAGCGGGAGAGATATCGGGAACGGGAGCGTGATCGGGAGAGAGACAGAGACCGTGACCGAGAGCGCGAGAGAGAACGAGATCGAGAACGAGAGCGAGAGCGGGACCGGGAGAGAGAAGAGGAAAAGAAGAGACACAGCTACTTTGAGAAGCCAAAAGTAGATGATGAGCCCATGGATGTTGACAAAGGACCTGGGTCTGCCAAGGAGTTGATCAAGTCCATCAATGAAAAGTTTGCTGGGTCTACTGGCTGGGAAGGCACAGAATCGCTGAAGAAACCAGAAGACAAAAAGCAGCTGGGAGATTTCTTTGGCATGTCCAACAGTTATGCAGAGTGCTACCCAGCCACGATGGATGACATGGCTGTGGACAGTGATGAGGAGGTGGATTATAGCAAAAATGGACCAGGGTAACAAGAAGGGCCCTTAGGCCGTTGGGACTTTGATACTCAGGAAGAATACAGCGAGTATATGAACAACAAAGAGGCTTTGCCCAAGGCTGCATTCCAGTATGGTATCAAAATGTCTGAAGGGCGGAAAACCAGGCGCTTCAAGGAAACCAATGACAAAGCAGAGCTTGATCGCCAGTGGAAGAAGATTAGTGCAATCATTGAGAAGAGGAAGAAGATGGAAGCTGATGGGGTTGAAGTCAAAAGACCAAAATACTAATCACCAGTTACAACCGGAGACCCTCCACAAGGATATGCTTCCCACTGTTTTCTTTATACAATTTCCAAAGGTTGCAAGATGTTTTTTGGTGGATGAATATTAAAATTTTATTGTGTAATTACTTGGTTCCATTAAAATTGGTTAACTTG + 8.8884033.515401-*44)55371.44469:8/.,3700,-2$86214/53/+(,3)+-)(-0)(%-,+/112),0+'/)/3054/2345'021111)112/-/-55610-656453213.(-,'13(115563,-0-2/54444-*-0433004525310/532210.%/463,/2/4004116321/,4/34451/231363+$.,/2*/*-110'0231531**-+/,+*,*,-))*(*,)(%)*'.//.50+)+)(&*/))*,#-+23/,+'),0+-0-*%+(*&-2,'.-215100-0-,53610*-0-,0..*-00.&/3/2,+/./0&#%+,,))($0#)+(),.)0'.200/(141++3..1.0..'*-',.(3/12-'.-$0)/10164.--0/-42.-3.4442+01/1.,&02..0-.+32464566032/-255/10-,'0,2-,1,53.1'+/+*-,1&42/0-2-4250'(&43,3/-122)/../$$.%-+'.,.*/,-()-,,$01-300/*&&/-51)'*16313*0,.1,((**,)3-002443520//(,2)*33*2120,+$1354.1132242%4/01460/'3246+53/2,.,3-422/001360)05540*0330634./(0131505.134024),00.'01.5/4256/113%/-4..33+--20060534./223.&(-455*3415433*/21,+.013-/.++2+303+5255,421+/%.002255(//4/5412(41/,/51+.1200/44/#5*42./**9635%66,46::39.824878.8655;557.6144734-/,*1280.8166:5672467-23//3222'(,.*53483627+8.4+7(38*2,8;4318468,43/88441862+.98:51564&+/0527111652/'./71621/195-21.86.2+3-'.-232-/64/017'8275/467373-29'*)8042.6/-3$5)/449254',3455456.2/64/235.0(,6440&**146122-24-.,1485(44)3:817-453,4615851.341633-.1*/*4-.-747/)*++#+.'/4.1,784.2212-(12883065358(69:7421443.(3.074/1664208:2579751./-0/44/1,.060)3$01/4/6.-.*0%87/,/9:22.54548+74,9+48715536.2+694781/0*030/1.7:840,,1:34543'163766,7.45.121853':9125;6056507./57%332558994.4186512894-5/67812%.34(05373.3705(58;-628.3.3/3,4/65+767.61612437:5228:26894537--),/5'4('&'.)&(240.0880738932336,10*'/305)*&*+,2&*/-22012,/'-22/0.*1++,01+2,2755**,-)/+(2+)03112/($%./&,328040202/),323-,%(,)1(+')(%,/$,/.04274'(3%400./.0051/73543,*(2/53.+0005156'4-,-415/0--2*3.:/446994/12*+)38+07://+/..(/232-42,136067--/.28:)41(3*288;8.341178&433162735556:;871+4.74259651.0/2.,*-7640.423,/979-5+++$.32-43.&.6(7517)2313*64658/7718186,311,3-04981.83/6*859759-6/:4449)50524-1968.&1/3+3204865729::.)622263-+52541.)(492240.431'0732.20*4-51-)(33-3-.*.*20400/0/011+63,3*)313+/.)&/3/'21/++1.2/0-1&1/520)425.2+/2'-10&3/3(/+60+,%3 @rCer/606/25_1870_CCS ATGGGGAGCTGAGAGAAGGCGAACGAGTGTTGGATGGCCACAAACTGGGGGAGCCTCTTGCCAGAATGAACAGCAGCTAGAGGAGCTGGCACGGCAGGCGTGGACCGCGCCCTGGCTGAGGGAGTGTTGCTGAGGACCTCACAGGAGCCCACTTCCTCCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTCGGTCCCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGAGCAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACGTGTTCCTGCGGCCTGAATCGCTCAGACTACATGTTCCAGCGAAGCACAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAAACAACACCATCTCTGCCAGTTTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAAACCAAAGAAGCTGGCAAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTTGCCAAAAGCCTGGGAGCTCTACGGCTCAACCAATGCTCTGGTGCTAACTGATTGCTCAAGAGAAGGAAAGAAACATATTTGACCAGCGTGCCAATAGAAAATGAGCTACTGGCCAGGAAACATCCATGTGATCGACGAACATTTGAAGATATCTCTGAAAAGGGGTCTCTGGGACCAAGACCGAAGGCTGTTTGTGGATGGCCAGGAAATTGCTGTGGTTTACTTCCGGGATGGCTACATGCCTCGTCAGTACAGTCTACAGAACTGGGAAGCACGTCTACTGCTGGAGAGGTCATGTGCTGCCAAGTGCCAGACATTGCCACCCAGCTGCTGGACTAAGAAGGTGCAGCAGGAGCTGAGCAGGCCGGGCATGCTGGAGAATGTTGCTCCCTGGCCAGCCTGAGGCTGTGGTCGCCTCCGCGCACCTTTGCTGGCCTCTACTCACTGGACATGGTGAAGAAGGGGACCAAGGCCATCGCCAAGGCCCTTGCTGCTCCTAGCCGGTTCGTGCTGAAGCCCCAGAGAGAGGGTGGAGGTAACAACCTATATGGGGAGGAAATGGTACAGGCCCTGAAACAGCTGAAGGACAGTGAGGAGAGGGCCTCCTACATCCTCATGGAGAAGATCGAACCTGAGCCTTTTGAGAATTGCCTGCTACGGCCTGGCAGCCCTGCCCAAGTGGTCCAGTGCATTTCAGAGCTGGGCATCTTTGGTCTATGTCAGTCAGGAAAAGACACTCGTGATGAACAAGCACGTGGGGCACCTACTTCGAACCAAAGCCATCGAGCATGCAGATGGTGGTGTGGCAGCAGGAGTGGCAGTCCTGGACAAACCATACCCCGTGTGAGGGCACAACCAGGCCATGGGACCTTCTATCCTTATATTTGTCATTCCTTTCCTAGCCTCCTGAGGGTATCCTCCTAAAGACCTCCAAAGTCTTTATGGAAGGTAATACTGATACCCTTTCGCCCAGCTCTCCATCTGATGGACCAGAAAAGCTGTGTTTCCCTTAGATGAGATCTAGAGGCCCCAAATCCTGGGGGTGTGGGTACAGCTGAGGGGAAGCTGCTCTGAGGTAAAGGTCCATGAACCCTGCCCACTCCCATCAGCCCTCATCAGCCTTTTCAGCAGGTTCCAGTGCCTGACTTGGGCTAGGACTGAGTGGTAGGAGGATGGGGAGTGGAGGGCATAGCCTTTCCCTAAATTCTGCCTAAATAAAATGCATTGCT + &%'/531016455.4/3.621&340.)33,0$-)*,+,2+$#*,()&&&/.13543/+2.%./2(4/-141'(,.3521,1&+30(,16236415.*'$,0/25/(1.0.4/(450142)1()3/4(.32,&,*-2,3.10/1.-/3.64)2+0/51$+)1-.51044.3-22.2/,0//(/14410310/-,1./0'*01%/-.(122,-/0&30//%//31,/'+135310/+/2*./.-+++)--,)/(114/-),$((*1,-,,/,0420*0+)(44/45102(+01.+.-))*0./.432*61+)*&+-02*(0.30.540--13.+&40./-0-(-),04/0)20&--1/21+..&'$*&'23/02056,&.21$/(+,,$(.+%&'-/%$++%-*/)-.-./1.+/'+$,+,//..+-*-4.,0021*/2/0*2/&-,/13*.151,*1.)//(-)-#,*+3(14'%+(.(-+(,*/(('.$*(.0/)*1.)+*.*+%*-*#$#&#)$#%(*/)21,01/'0)/.++**,/%,-*./.03102()).1,(/*25311(-/+4/001+..-3(312443134*0-013-.+,.0/).2)36+$--*,(.+,'*$,-(&-0+(+&&))/0-//).++.&..-#,0021//04,-3.%)+%*/,1)&+&)/++*)(-.1223+34/,1.&().-'%)0.1*-%)$)/,.)000.000355/0&,))((%'&')**+.+*+'*-)('%+,*,*+&//(%-/+-111044.*%&&$*(-')./*$&+.*1+.+-%&,.*/0/-.).*.)-+,.,0./216--(%)1-#+*&$()+/15322-4*3-.2.-(,2(0$.//.252./.213-41/255312201.,52,(0()-1.*-,)))/()+)/.014+--142.0.-22.)0*./+/16..3+%/-'*/)%')#0-*1155/5**./--,/0-*(,.,(*1*/-.,1-32*1501+,30.%++%,-,30-5102///0.$0/334340.,,'$10.11%*+(+#,/3112/2124%(,'+,0..40/354100#300,0.11(-31,-4(0*0*1-+)3.6%/'.'4-,3)4),-4260+../56+42/1-/-0.1+)/.*')).+0/&+/-/5,)33)22163250040-54+,1/0661/3115446)52344261).0126/5001040*(-045,,20(014.-/-(.000315/53-'.11/135510,/53+4-.2.5506526**-356555.,+,)/11)/..//2163264/)-.-1&*%*54-41104.-5.100,0-.*4,$,,1*+--,/+*(/10//3425330232$'(++..32.+//,,)(+.&0(,))(,../**(.'*+4232/.'30/30-//*((*,+101/.(,,//02/--52((24-/1()*'+*')$*##.''*%(#*%&)'('+1.1/)-0-20)*'+++%)*+'..1'*-(&$%$&)+',,/10++.,1/22*0/,&$(#$',0.%,*&#%%,,,/+%*)+'*,*(-,-0/%('0-*,&*')#(&'.,)-+.--+%*+(+**$,.1,-**-&(&(.(*,'$(()$&&(*/1//+&/-*'--(+//21-.-/10*/0-//1.1(,/0,,20,-/&+,,&$',.21-..-0.&-+.0-.+-**',,'#),+*.+%+/-,,+-+*--0**,+%(+.,//&./+0+.&$(%(*.+)+,-1*0+..1/%**,,++/)**1.,'-(%$(%*)(&&')'%&$'*+,0++*+-()*-*-1,',/,-.&)'+%.+-**$+.*+-)$)&$-,+)%$#$-.'%*/,+0./'0/., @rCer/607/1957_63_CCS ATGGGGAGTCATCCAGTCGGCTGGAGTCGGAGGTGGTATCTGTAGGGGTGCGCTTGTTGGGGTCAGGGTAAGCACCAGCCACAAAATCCTACAAAAGAAGGTAAATTACTGTCTTTAAATATTAAAAAAAAAAAACAAGATCCATGAGTGGGCATCGATCAACAAGGAAAAGATGTGGAGATTCTCACCCGGAGTCCCCAGTGGGCTTCGGGCATATGAGTACTACAGGATGTGTATTAAATAAATTGTTTCAGTTACCAACACCACCATTGTCAAGGCACCAACTAAAGCGGCTAGAAGAACACAGATATCAAAGTGCTGGACGGTCCCTGCTTGAGCCCTTAATGCAAGGGTATTGGGAATGGCTCGTTAGAAGAGTTCCCTCCTGGATTGCCCCAAATCTCATCACCATCATTGGACTGTCAATAAACATCTGTACAACTATTTTATTAGTCTTCTACTGCCCTACAGCTACAGAGCAGGCACCTCTGTGGGCATATATTGCTTGTGCCTGTGGCCTTTTCATTTACCAGTCTTTGGATGCTATTGATGGGAAACAGGCAAGAAGAACCAATAGTAGTTCTCCTCTGGGAGAACTTTTTGATCATGGTTGTGATTCACTATCAACAGTTTTTGTGGTTCTTGGAACTTGTATTGCAGTGCAGCTGGGGACAAACCCTGATTGGATGTTTTTTTGTTGTTTTGCTGGGACATTTATGTTCTATTGTGCACACTGGCAAACATATGTTTCTGGAACATTGCGATTTGGAATAATTGATGTGACTGAAGTGCAAATCTTCATAATAATCATGCATTTGCTGGCAGTGATTGGAGGACCACCTTTTTGGCAGTCTATGATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTTTCCTGTACAAATTACTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACATTAGCTGCAATGATCTACAAGAAATCCACAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATACTGACATTTGGTTTTGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCAGCACTTTTGTTTCTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCTTTCTTTGATTTGATCCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAATCAAGGTTTCTACAGCTCATTCTAATCATCATTAATGATGTAATTGGTATTATATAGGAACACCATGTTTTCTGCAGGAAGGAATCTGAACATATTAAGGAAAATGGGGGTGGATAAGAACAAATATAATTTATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACTCCTAACTATCCTGTGTGAGAATGGGAATTTCAAGTCCATCTTGTAAATTGTATATGTTATCATGCAGGGTTTGGGCCAAGAAAGCATGCAGAAAAAAAATGCCATGTGATTGTAATTATCCTGGATTCAGAATAACATTGTGATGGGGAGCCAGATCCACAGTGGTGGGGAGTTCTAATGTTGACTATTTGCAGGCCAAAAGATGATTGCTTTATAATTTTAACAAATCATCGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTTCTTTACTAAGGAGTTCAGCTTGTGACACAGATACATCCCACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTG + IHHIJ@GEDGJIH>EJEHGEFKI>HHIGEE@K@9JAEJIJ9GIGIAE9IGKHGA6EI6JHFABE?IH@DI@FHJFICIKCKJKJKEKI>IBEKKK6JJFJEJKJFB@?HJHA>CF4FI;H?J;AHDDHEIKJDF%1D+JHCJ6JAF;HIBJ.HJGJ@AEJJBFHFJKJI>HB9AEHJKJKKKIKIBF?IHKAEBGFE@II;JJJIIIKI:IAJHJJJHGHJ=HDG7JG>J;CKHHHKIGEEEB3@IIKFKK=EJEGKKHG3EFGKAEE)7@ABFIJAKF;JIIK@KEGKFHI@KHCKH@CDDFEEIDIK:JGIKIKCBJ@IH4BFCJA9G=JIA4CGGJKIHKIJE:FKHKIJ@KIJKKFJKJ2DE9JJIKEIHFCJCEEC=DAD>HIAIBE,EHEEI/E?<827G@CBG@=9F:F?:HE>GJAEEIFHJI:HFABI>AH7GEI>EJGCGHGCFFGFECBIE7?EGE,D@><5@F?FHHD;H8I@/GHHGDB/GC=CBGC$9<@CIE7CAH<>EED7ABG+FDA>HAIE;*EF@EHIGE?F@BIE@8<>EHFIGG@D7>FBFCEF8FIGA>-=A:2ACE8HJ@C@HGEF=?FHD+?<@=?HGJBE>.>@E9+BCDDBE=DJDAD@CEE+@6HG@?CGE=GACEC?F?>7:;B6BGJAFGCCBA7?<;6E9G:BBDCB'8E?:GIG+GH8B@FB>C6FCIGFFBA=CAHIDA>AJ:FEECGFC@IHABADEA@EFHJAFDC>HGCBG@C8BFBA4B=C?BGI6GAGICFCC>IGFED2@;EAC-=DHAEG*BFEFBEII>?AEHIBF>3=;2,DA@CE9EGFC.FHHADHECE)CBGDC18A<@9::&:GDCBI:@D5>GA0H<9GGF:GGFIE8CCG)GAEG:DD8E=BCFCFCEFIGEECABCH9ICHBHGC=BI;F-AEGFIFIIGE6E>:?BB?D9DAB7:D>GHCBEC>H=G8B6JIJ;FDF@A&EI?@FICFGBIEJFIFGI@IE@BHHED?/@EI@EIC?D@7D>9:DEA'@?DDDACBF;GDFEB@:C>>7DDE5:@3BE18>*D>B4FA@DCCBC@*9>G?C=?7=>7+A>D@D;CAB@39'-DDBB?CDFG>CECFFDGCFDEE;@AD?FFGEG=CCDCCGABGGF7>B@.B@ECEAD4EAF=:99%A@DG>E;ABA'@;:A=F>FDCCA?>C:;C?FC;EG?:C;D@EEBD57C:@A8D>FEC6@ECCG>>D>8B4FCCC8D<:;B4A?CBB?;->:1>@>A21B>334?==95=.D@><<:'BA9@9<>65@@FD=:A2=:A1>B=:?=2E?>B<6*7>(=>??F34>.C:B45B6D@=73C5&;+2DGG:9A>B30,+;#:<802C44BD@E/=:6*?:A>DD:?B=FDD@BAB88$2->BD@7>;=G?':C>CCEBA=E<:CC6<;FA5;9:BB?72=>@E)E9)%;'A@B@?3F?DC=GE3C;;BBABE:):50%><4>/@F04EED=EB>:>C<2=856BG5GF=5@F@=A;>?@0=A9G?=?BB<)?E>DBEFBD2A<>8>E9:?>F>:CCFA8ADA'87B@A>.91:;$92A<>FD>B<=A=+?/8>;.ABEAE;<;EBB?.B?>->F>E@BG3CB@<;2A<9<1.;>@@EGEF'AD?@5>$;92469AA7B/A8;>B>99?8)'::)CE>=<:A:C;D+CE>8$8@87GC>E;494E3B9A@1<8,>(EC/B59CD=G1=@=>@=@2>CD@@'=8=;?;=9E?A;:&@*;(:>5CC>BBDF9C:;ECF5C1$E4;B9:CDB5?3A/B)983EEGGA2B1?CB56?DCB?378%6==/=:4<@:/*#9@>EA?F68@?C>DB;A=9.2;A@8;3BA4=:CA@0BF3@DA04>9@7?C@-;DE8B@@ACF?;@2A>CF(B@/?BAG,A>FBDCBB><&<@;BA:A<@A;BBDC93;CEE&=47;>?A90D9E@B/>8;>?>?;,65-48=F9D0E>GBA;-???@6;/<2?A?B78;B@7522>5:B:BABDB8::55:>D>5ACFE/;9=83AA:@6??CD?AB@>==FC?;3;288B1=A?/@=<D?A@CDB@84@DGF>C>=C57AB1@;BEB3BA8-?@2GFBFGFA<7D9?=>,<>BFE>:B7A;CAC'5;>;@@78646)9AC8B?:*?ABCA:CF=74@<;A3/88-:BBB?A6@?@E<>?AD?A7D;:9<9BC;4,A9B=?DBEFCDF:>?G?EFE>E@BE;95AFFC=E@/9FF<@,B)=>8B?C9BE8@AB@'=>8:?A;7:@>EA0CA:=?9EC;2A>DF-FBA?DBCGGE;>&:?A?ECC2;A@A;@8G)??>;=:BFGFB06@@B=>>(@8@C:9B=;=:&@@:9D@B?<.DBBA @rCer/611/24_2612_CCS GGACGCCAACGAGGCACAGCAGTACTACCTGGATGCGGATGAGGCTGAGGCCTGGATTGGCGAGCAGGAACTCTACGTCATCTCTGATGAGATCCCCAAGGATGAAGAGGGCGCCATCGTGATGCTGAAGCGGCATTTGAGGCAGCAGCGTGCGGTGGAGGACTATGGCCGGAACATCAAGCAGCTGGCCAGCCGGGCCCAGGGCCTGCTGTCTGCAGGCCACCCTGAGGGGGAGCAGATCATCAGGCTTCAGGGCAAGTGGACAAGCACTATGCAGGGCTGAAGGACGTGGCGGAAGAGCGCAAGCGCAAGCTGGAGAACATGTACCACCTGTTCCAGCTCAAGCGGGAGACTGACGACCTGGAGCAGTGGATTTCAGAAAAGGAGCTGGTGGCCTCTTCCCCGGAAATGGGGCAAGACTTTGACCACGTGACTCTTCTGCGGGACAAGTTCCGGGACTTTGCCCGGGAGACTGGGGCGATTGGGCAGGAGCGGGTGGACAACGTGAATGCCTTCATCGAGCGACTCATCGACGCGGGCCACAGCGAGGCGGCCACCATCGCTGAGTGGAAGGACGGGCTGAACGAGATGTGGGCAGACCTGCTGGAGCTCATCGACACGCGTATGCAGCTGCTGGCCGCCTCCTACGACCTGCACCGCTACTTCTACACGGGTGCCGAGATCCTGGGCCTCATCGACGAGAAGCACCGCGAGCTGCCAGAGGACGTGGGGCTGGACGCCAGCACGGCGGAGTCCTTCCACCGGGTGCACACGGCCTTCGAGCGGGAGCTCCACCTGCTGGGTGTCCAGGTGCAGCAGTTCCAGACGTGGCCACCCGTCTGCAGACAGCATATGCTGGGGAGAAGGCAGAGGCCATCCAGAACAAGGAGCAGGAGGTGTCTGCCATGTGGCAGGCACTGCTCGATGCCTGTGCCGGGCGCCGGACCCAGCTAGTGGACACGGCGGATAAATTCCGCTTCTTCAGCATGGCCCGTGACCTCCTCTCCTGGATGGACAGCATCATCCGGCAGATCGAGACCCAGGAGAGGCCCAGGGATGTCTCCTCTGTGGAATTGCTCATGAAGTATCACCAGGGCATCAATGCAGAGATTGAAACCGGAGCAAGAACTTCAGTGCCTGCCTGGAGCTTGGCGAGTCCTGCTGCAGCGGCAGCACCAGGCCTCAGAGGAGATCCGCGAGAAACTGCAGCAGGTGACGTCTAGGAGGAAAGAGATGAATGAGAAGTGGGAGGCCCGCTGGGAGCGGCTCCGCATGTTGCTGGAGGTGTGCCAGTTCTCGAGGGACGCCTCTGTGGCTGAGGCGTGGCTGATCGCCCAGGAGCCCTACCTGGCCAGCGGGGACTTTGGACACACAGTGGACAGTGTGGAGAAGCTCATCAAGAGGCACGAGGCTTTTGAGAAGTCCACGGCCAGCTGGGCAGAGCGCTTCGCTGCCCTGGAGAAGCCTACCACGCTTGAGCTGAAAGAACGCCAGATTGCAGAGAGACCCGCAGAGGAGACTGGGCCTCAAGAGGAGGAAGGCGAGACAGCAGGGGAGGCTCCGGTTTCCCACCATGCGGCCACTGAGAGAACGTCCCCGGGGGAAGAAGAGGGAACGTGGCCTCAGAACCTGCAGCAGCCACCACCGCCGGGGCAGCACGAGGATGGGCAGAAATCTGCTGGGGACGAGAGACCCGCCACGGAGCCCCTCTTTAAGGTCCTAGATACGCCTCTGAGCGAGGGTGATGAGCCTGCAACGCTGCTAGCCCCGCGGGACCATGGGCACAGTGTGCAGATGGAAGGCTACCTGGGCCGCAAGCACGACCTGGAGGGCCCAACAAGAAGGCTTCCAACAGGTCCTGGAACAACCTGTACTGTGTGCTCAGGAACAGTGAGTTAACCTTCTACAAGGATGCCAAGAACCTGGCCCTGGGGATGCCCTACCATGGGGAGGAACCCCTGGCCCTGAGACATGCCATCTGTGAGATTGCTGCCAACTACAAAAAGAAGAAGCATGTCTTTAAACTGAGGCTGAGTAATGGCAGCGAGTGGCTCTTCCATGGCAAGGACGAGGAGGAGATGCTGTCCTGGCTGCAGGGCGTGAGCACCGCCATCAACGAGTCCCAGAGCATCCGCGTCAAGGCGCAGAGCCTGCCCCTGCCCTCCCTCTCCGGCCCCGACCCCAGCCTTGGCAAGAAGGACAAGGAGAAGAGATTCAGCTTCTTCCCCAAAAAGAAGTAGCGGCCGGAGGCCCCCGCGGGTGGGGCTGGCGGGCGCGGCAGAGTCGCAGAGACCTGGCGCCCCGGCCTTGGCCTCCTCTCGCCGCCGCCCGCCTGTCGAATCGAGTCGAGTCGCGGGCCGGGCCCCCGGGCCCCACGCTGCACTGCAAAAGCTGCCTTCGCCCGCGCGTCCTGGGCCGACGCCCCCTCCATGCCCTCGCCCGCGCCGGCTCTGCTCCGGGGACAGGGGCTCCCAGCTCCTCTGGCGCCCTCGGGGCCTCCAGGCCTGGGGCAGGAAACGGTTCTCTGAGGCACACGCCTTCCTCTCCCACCCTCCTCCTGAGCCGAGGGTGCGCAGGCCCCTTACCCC + 8845828+;;=92?>58;;=79<4:69===:=;29>:>5::5/<46:335,848;2,2.:88755299,9.35<5879;6895-3><14:=88*8;9.80;0:>6;59.9>=97<7)21;<;<<7886<=>=?<96<=:>-;;90<;7;99;=5>45;.699:579;;97174<>97<6>472:3;6=9::<8>,>;9*:799;:>>6=8:=592>;>79:7;=7*;77848965477:<:;;?518;/#8;32==808981;60=8>=<3;4,8579;5?/689;:8?;4<6?<;:<:83=8>>:,1-48;=;89;:693.;4:047<42;6?97>=>49796?778><>:9<875=;5=<=9==:9:52:=8::2=<6,=8<=07;:7=8=<95=.4;;/5*:94*5<<><;;9;';79;<=6=3:9;=8??=>7;;577<2;3399<>8,>;.:92/78469<;8;>/94;><62:<757==97>190=49:809:==9:3<<=8<>>>6=<9?7====99;6><=9>95=99.8834;<8:4;=><6:78=>->=99:7>7=??;216:9;:86>9<9908<754=;>;:;97::<;<>=;>9=;2364,<=934;>/==85;9=8:;9:>83>>5<86,:9=;78=>;?;49>?=>?;=11;2;659195:=7)<99:>=?40;88;<>:>3=>8=9;:=?8=5>481>:6,;<>?97<=.=>88=8679=9>;??=::9><;?>>=4:>9<9=:=4$8<8<,:8;678?>4;8<848=97;;&3,/7<9+8898=3=8<>==:8:;?;:/>99:==68>><;?29>=>>6+7.759>=6;877?>>76==>;>=6=430<>2;;.4<9<9?:;>:=?8>=:;>::64>><3<<=;<1/>>3=<6=<257?2;8937=;?6352290,7:;18=:9=>>2;:=>>.;/;;?>83=:==5/31:8:97;76*4882:98;<;>;;?986<>>?780;96==8:>3:299=535?>;?;;;=90>>>?>;:>>2;9+<8#:2983488=3<31=<9><95?>?;<9184:97:6<>==:;$;:>==?=.87;9>9>><)=89:.4792<=8::979/==87:7'1.4499%;<:(-1);>??>;>2>7371:<6<>94;5?:;<36=<>*88:)9.>;98=9??=:>2==;>;<>;?>9:31;5579?6<983;>>8=.9>6;3:>830/994>>98>:97955>=;8?:82;;;:199<;=283:9488>>1>7=>>>3><=9:2:;7<63<:33>;;>?:><9>;45=:77==<>:7891:99=;377?<=:*:==;3<<>;:<&<;=;96;;788?=6)61<<:2<588:;>:;8:69:4'-+88+<58>=><7:<>78>:=?;?>>*5:1+216=;=>:>>5=::/5:;5??;4)4546;6<0>?1=>;:>-$9>9===:<98=7=;9=;==,>>96=??<5;;2:7<4;<15:>68?1;;=.;7=2>:::;>;095>><>9>5>798?;;<=9??;>?=99:?;68=;889;68>7=8=8=;6;>.<::==8><247;4>937=57;;;;=6>=;80=>>9.3=7<86<;88?;84;>7<93778=5=>9=>5>148?>>=8?;*:=0?=71:8=66>;.:6:?:-<:4><<=98::-<39/7::=9=<;>?=9?66=7=<-<:<>:19>9<25::<9<>/<4;9>>=;>:6<;=8;63596639<=7:>2?,=90;9;:8?2>?=*==730*(5=;53=;=69??89:6=<==?>=;9=?>;=55<:;:7=>:9?>3=>;59;<;>>7:3<::<8%26363)8948>9<;:9=8=='9778<67:::949=>;>4364=>776;5:<>:2=8:8<>?::::?86:5:827>=508<169:6;7:??><>866;9;>>9590(862=:>:8:<5(=<2??9=77::62=:;>5>;?=?97=:=;><:6=+;;9>;,831198>>;4>9?6;<=:6)548=;8:8>9?73>8=?9?6:?:43?==?>:=>:8>-897;*><94???>5;=>=?>>9>=>=?90>*>;;<8:):985;9;;8->5-95-9:7>>=52<>46/13:?66:==4><2(<8;2;2?897093=6<>=?=9?=3?=<6=:;2897=:?<9:<2:=791465:;8=8=;%7:<2?=?>:<;2:8::9<;,8==:9.==?/<=>899><8<<<8>:1?>4=559=)767<9(6:670=>664/:>;2:=?7:=1:?;?=99>8-;>5;42:77=:36?>;>;?>>8==05';:;7?88?>5>:?4)<978>:>/=<<=5=>:>?579475567:7>:6399?88??47;6==7;9;+;:>6?:6=;;889?0<;;7<9'44; @rCer/613/1447_53_CCS CAAGTTGATTGAATATTGTAGGAATTACTGGTTTAGAGTAGCCCAGTTCTCGGCCTACCCTGCTGGTTGGGATTTTACTGTATTCTTGAATGCACTGGTTTGAAAATATGCCAGACTTCAGCCCTCAAGGAAATAAGGCTGCAAGAATTTATGAACTCCAGCTGGAAAGGGTAAAGGTGACCTTTGGCTGCAACATACCGGACCTTACCCACTGATGTCTTCAGAACATTCCAAGGGTTTTCTCAAGGAACATTTTTGAGCTAGAAATTAAAATGGGTTATCTGGCAGACTGCACCTCTTGAGTCAAAGTTAACAGTATTCCTTTGAATGCAGTAAGGGAGGCTTTTCTGCGTTAAGGGGGACCAATCGAACTTACGCATTCCCCGGCAGGTCCCTTTGCCGCCCCTACAGGCTGGGGTGGCCCTCCTGTCCTCAGGGATGGGACTCCCAGTCTGGTTAGCTCTGCATGTATCCATCAAATTAAAGGTTATTCCCTGGCCTCATGCCAGAGAAAACCAACCCCACCCTGCCAGCTGGGGGCAACAGGGCAGGGATTTTGGCCTCCCAGAACAGCTCCTAGAGGCTGCTCATGATTGAATGATGTTTTCCCAAATCACCTAAATATTGGTTTGCTTTTTGTTTTGGGAGAGGATTTGGCCTCTTACTTCCCAGTGGATTGAAAGTTTTATCTCCTGCCCTGTCTTGGCACAACTCTGGATAGACTGCAGGTTGGAATTTGCTGGAGTTTGGTGTCTTTTTCAAATTCCTTTGGATTCTCTTCAGCCAAATCAGCAGTCTCGTCCTATGGATGAAGTGATTGCAATTTCCCATCTGCAAAGCATCTCTCTAGCCCAGATTTTGTGGAGCCTTAAATACTCTCTCGCTGCCACCCTGACCCCACAGCTGGAGAACCTATGCTTATGTGGTGGGCAGGGCCACTGTTGATGGAGGATGGCGAGGAAGGGGTGGTGCTCAAAGGATCTGTGGTGCTGGAGGTCTAAATGCCTCTCAGGACAGTAGGTCAGGAACCTCAGAGCAGCTTCATGTCTGCCAAAGCTGAGAGGGAGCAAACTTGGGAAGCATTTTGCTCACTGTCCTACCCAAGTTTTATAGCATAATAGTTGATGCCAAAGGAGATGGTGACGTCCCTTCCACTGCAGTTGCTGTCACAACCTTGATGTCTTAAGCTAATGGCCATTTTGCATCTGTGTCTTCAAACAGATCCTGGTTACAGCCATTTTCTATCGTTCACTTCTGGGGTTAAGTAATGCAGGGTTCTGCAAACAAGGTGTCGCTGTCCAAATGTACTGTACTGGCATAGAGAGCACTGCTTTGTTTTCCACTGTTGTAGAGAAAACTAGGGAGAACTTTATTTTTCAATAAACTTTCTTGTG + *4.1526-4-77:8:;:6:::4.21+,78/*46**14,./159-4:;8:572&//56917266878;96,00/45(8732:83)53577468/2-6734../31.-/-):>69<;=56<7=>94568<95:;)3459862:=?863186-7444(00>;6;1=?;<=1=?82??7=9<=<<17;,:16#282682.5=:>68=6=6=%*66;8><88=35$8318-8393949;>8,::7&64/2(>051:;>=>>/1=>7:28:<383:9;/=;;8=4:6;;>6:1>>>9=37;1967&75879<;2=1+5-;:;?77=92=;<62:1?;68?2:;<=)>>??>?;>5:;8;(5=2>1=9<:-4B48@@;8:0<;0#007BC8<=?/C@BBC;B>'+00:88?:::.7<,*A@@48,29>&>5<8A@BB8=:5B?@B/>AABA5C+*;*@=<477@:054=@@=A?;==;:0A7B9A?A8A66@+A=AB5B@BB::)?9C:B@<)4@>:A>@=5;/?9??B>;==5.68,>65-9730;238543);?6CA-?=EB@99:.5594;<86)4<@=A=><8>?*=5+:=;B3A=<.?0;AFA:-AC7;??@?@?A4F@ACGB@/EF;FD@>9566A%GBGAA=<;A?-=A7:@E;+<=5A;?A>AB=AA@4@C:A=)@FB=?9=D6B:D=@7>BDC0C?9?>16<99@B@D>BC>@@?:=;28FGG;B>@CB=/<9>:2>=25698%;99>>5::714:28,8:7169=76:39;:::?4696927$6=BFAB=A>A<9?B@;@A=AF6C@AE>B7@CA/>4;>:)@<4@8?>A>>/8AA84A@?0A?@AAC1:8=?=A<=>><7(<<,=C.C?B=>==@+@=<=><:5:@:0;CC>=<=CC>7$8:?7-9+)57;96;B:B=:;='C;A9/@C@:?9<=<>?8>7A7;>>=963>.:>=8044588969/@???9=8)()>=?>>?<-;5'?BA,=99>;;A>8)3.06BA9;CBB?<<(9:6?=;62B;7>7BB>@B);*>&68A9?;BBA8,0%<:>=>>(7?5:7?<>;?78=AB::<':>95??3>&:=A8B:A>>B?>*=978+:5;AAA>9@?;==<6<;/1?@AA165><9><5:===?3>?;>??42>:%:<6:;@ @rCer/616/1433_54_CCS ATGGGTACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAGGTGTACGCCTGGGCCCCGAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCTCACTGCCCTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCTCAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATCACGCCCCATGCCATCATTTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACATACGGGCGGATCATTAAGGATGTGGTGCTGCAGTGGGAGAGATGCCCACCTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCGCTCTGTGGAGACGGGCCACCTGGACGGGGTCTTCATGCACAAACGAGCCCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGCTGTCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCTGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTACTGGTTTGATTCACTGGAGCCTGCTGGAACGTGACCTCTGACCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCCGGGAGGGACACAGCTTCCCCTTCCAGGAATTGAGTGGGCATAGCCCCTTCCCCTTTTCTCCATTTAAGAGGAGAGTGCTTGGGCTTGAACCCCTTACCCCACTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCTTGAATGTACCAGACCCTGGGGGGGTCACTGGGCCCTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTATGATTCCCCTTTCCCCAACTCCAGGGAATGGAGGGGGACCCGCCAGCCAAAACGTTCCCCCCTTTCCCACCCCCATCTCCTCCTCTTCTAGCCCATGCCCTTCCCCGTGGAGGGAGGAGCAGGGAGCCTCACTCTCCACGCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTCCTCCTCCCTCCCCCCACCCCTCCTCAATGTAGTGGCCTTGGATATCCTGTTTGTTAATAAGACAATTCAACCAG + B;@B'==FCKH==+;@GJ@HE>=$JD8DJ5DHCKEI9EJJIGA@>KFIBKFIHKII9K@FK2HA):?@EJJIDIH>:HDI5DIIEH6KGJ@IBFGIIHIFBC=:1?;HK0JJJHIJGCDK=8JCJKJFGEJIHHFJJG1EHIF68DKIJHH3H69EGI*G:>CJ@BJH;KCABABHI3;,8B??B3B6C9C7B>KAJID=AE@I@IH4IJKJI:BAC@FH+@EE@H>GGCG=I9DH>CDDAK32;ECCI0J4=HEHF;JGJFG2D=I1;FEJAAKKJFHHG<@E.IC9H6JE?J;FE,D8DCC@9@EDCH5B5CJGAA5>+:1HHJJG:HKAG@H?FKFJICDDHDB%84?8JBIKJ54J@4<4DKKK&HKKEKK/FGIHKDFKJ%HIII9IKK*>KK3GKK-IKJE/=CFE#HG?J8HK4CGJ8C>FEKDEJJA?EGDK*GIHKGHEG.JHIHDKI$=JHIJKKK3KKFJHHD=BEDJEH0:EKG>@I0KKK.J@IHJIKK?19G)JJ.KKKII@$B:K,JJ,K4I7IF4H?K,JCF@DEHK3G?EHJ%?KKKJEDJ7GIII @rCer/622/1834_48_CCS ATGGGCTCTCCAGAAGATTCTGCCGGTTCCCCAGCTCTGGTACCGGCTCTGCATCGCGCCGCCATGATGGCCATCGTCCGTACTCGTGCTCAACTATTGCAGATATCATCCGCACATGTTTGGACCAAGTCCATGATGAAGATGCTTTTGACCAATGGGAGGCATTGTGATGACAACGATGGCAATGCTATTCTTCGAGAGATTCAAGTCCAGATCCAGCAGCCAAGTCCATGATTGAAATAGCCGGACCCAGGATGAAGAGTTGGAGATGGACACATCAGTAATTATTCTTGCAGGGGAAATGCTATCTTAGCTGAGCACTTCTGGAGCAGCAGATGCACCAACAGTGGTGATCAGTGCTTACCGCAAGGCATGGATGATATGATCAGCACCCTAAAGAAATCAGTATCCAGTCGACATCAATGACAGTGATATGATGCTGAACATCATCAACAGCTCCATTACTACCAAAGCCATCAGTCGATGGTCATCTTTGCTTGCAACATTGCCCTGGATGCTGTCAAGACGGTACAGTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAATACGCAAAGTGGAAAGATACCTGGGGCATCATTGAAGACTCCTGTGTCTTGCGTGAGTCATGATTAACAAGGATGTGACCATCCACGCATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTTTTGGATCTTCTCTGGAATACAAGAAAGGAGAAAGCAGACTGACATTGAGATTACACGAGAGGAAGACTTCACCCGAATTCTCCAAATGGAAGAAGAGTACATCCAGCAGCTCTGTGGGACATTATCCAACTGAAACCCGATGTGGTCATCACCGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTCATGCGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATCGCTAGAGCCTGGGGGCCCGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATATGTTGGAACAGGAGCAGGCTCTTGGAAATCAAGAAATTGGAGATGAATACTTTACATTCATCATGAGTGCAAAGACCCAAGGCCTCACCATTCCTCCGGGGGCTAGCAAAGAGATTCTCTCGGAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTCTCTGGACCCTCAGCTGGTGCCAGGGTGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAATCCAAGCATGACTGGTGTGGAACAATGGCCATACAGGCTGTTGCCCAGCCCTAGAGGTCATCCCTCGTACCTGATCCAGAACTGTGGGCCAGCACACATCTTACTTACCTCTTCTCGGCCAAGCACACCAGAGAACTGTGAGACCTGGGGTGTAAATGTGAGACAGTACTTTGGTAGACATGAAGGAACTGGCATATGGAGCCATTGGCTGTGAAGCTGCGACTTACAAGACAGCAGTGGAGACGCGTTCTGCTACTGCGAATGATGACATCGTCTCAGCACAAAAGAAAGCGATGACCAGAGCCGCAAGGCGGGCTCCTGATCTGGCAGGAGTGAGCGCTAGGCAAGGCTACTTCAGTGCACAGAACCCAGAGTCTCCCTTTTCCTGACCAGAGTGCCAGGAAACTGTGGACGTCTTTGTTCAGAAGGATCAGGTTGGGGCAGCCCCCAGTCCCTTTCTGTCCCAGCTCAGTTTCCAAAAAGACACTGACATGTAATTCTTCTCTATTGTAAGGTTTCCATTTAGTTTGCTTCCGATGATTAAATCTAAGTCATTT + 2,6330,$/5-003(.)631,45*21-0345)'453,//#,'2$32/56640+3510*1+02*/13114%#%/*)+,3+*15-,./(5565622/44*4312.+.1/335/5))++.16105+.4(30)04+1./1245+3/&&20.-"$+3)/+464143*)+4025*0001)54011/2()651)./26,55,5333202/*43,53601$//2)+52/13&0-153(-04.52445+&(5624.5460.2&0-'1+--*.)/)15223%.)))/.+432315-11+)1%014666,34(3.53664$/*04264041.6/$.405124.//0-0-.-5).+1114.-*-531-(1/00.02%4*603(0/$(*14+/5-44.54//00/2&/66/135+/++,2887+2246-3451683:56876303,3/05(22&11*43250113.5.368736954-.-3+:;365235314851)25-3773952('11299;4/42(403)72(+..3-0+/3)/3/10*+1((2$/(5/14/*.-,000/01)0302402535401254*1365/,3%/2*%/2)1+0%.)0011&)(4411&/1154%.4,0/(0.03.21/.&//-22./.6-/'160655*(-#01$332+1564-/306.2/030205/5,34*464223131,2-35642-2(.#.-*50004/1*+/53--,)#00.241+0$.1401552.2-).',21*+0005/1511165,402323.5604,211051(4./5256./004/(-661556243.354/-*1535645.-)20/(044)21/4/'+00-40/25/--43.4*34(.3)*52'%(*5,5405125362&/3*5.(3*,1$1.0133*.,+023/*162./151-/1-/(5/)00404,63161131//052205542-$/%(.1(.*#%.-54111+0*306121/4'6104142352.2/#+/1646162001*5-01.%$**61.+,01,*-('1.$)(5/.,5101,.*454*+0).(4/34)*3)40--,/&.,00*-)0*/(%--0-/*#$",&&&(.1%+%)*022,0&012/1101)1-&,(/*0++',1,1-001.)%/.02-0110(*('-0,..%'0,*&-+/,-00,/22./)1.'+/$+.1+,-.%#++*2/,0-0,(0+*%&$)*,$--%*1,-,1/0,.--0/.$,.)0(&&&.+-/,-&/0+-%,&0-,02121.,&,*-$$.1/,/-*#&%%.%0-$+21-.0-+/%+-1.#(#*.0+/&+./),*0-0.#+./1110$*&($'--00-12.0/'%%(+0&(',0.*','),+%(*-,.&/.0/,/0+++.0'.*/00)%&/0)')--'--0/0(,/+++,10,.,&,&1-%--$%,--*/(0020.1*0&/*0,.0*.0-+#')0.,110*%,1111/&01-0*)+'&)&$,..0,,'+.10-)#/1/+,'/11-'01/0*$,-122,011)&-)/--02.1,1+1++&00/&/,,%,121010%/1/+&//%+&,+/%,.0.+/+12.21011-1,1111-+..*-0+*##+(,--&)-,&&0.(0,*/**(+&*)+(+%1-)1(%+/0())10--.0..-2.1*/1),%.+%+0,1*+/1'/**000-(*,01.,0+/0-.-//&0.,-')110-.+++-/&0-10..,*,).-01-/%+0-11-1.-'0+0'''11(-*-22.',220/-211+-0--121-+%-0-21--,001, @rCer/624/25_1934_CCS ATGGGGACTCGGCAGCGGCGCCGGGCGGAGGGGGAGAGCGCGGGCCGCGCGGGCGGGAAGCAAAGAGGCGGGCGGGCCAGCGAGGAGCGCGGAGAGAAAAGGCGCGAGCGGCCAGGAGGGCTCAGGCCGAGACATCTTTCAGCTGCCGCCGCCGCCACCGAGCCGCCGCTGTGCTCACTGATCCGCCTCCAGGGCCACCGCCATGTCGAGCCGCGGTGGGAAGAAGAAGTCCACCAAGACTTCCCGGTCTGCCAAAGCAGGAGTCATCTTTCCTGTGGGGCGGATGCTGCGGTACATCAAGAAAGGCCACCCCAAGTACAGGATTGGAGTGGGGGCACCCGTGTACATGGCCGCCGTCCTGGAATACCTGACAGCGGAGATTCTGGAGCTGGCTGGCAATGCAGCGAGAGACAACAAGAAGGGACGGGTCACACCCCGGCACATCCTGCTGGCTGTGGCCAATGATGAAGAGCTGAATCAGCTGCTAAAAGGAGTCACCATAGCCAGTGGGGGGGTGTTACCCAACATCCACCCTGAGTTGCTAGCGAAGAAGCGGGGATCCAAAGGAAAGTTGGAAGCCATCATCACACCACCCCCAGCCAAAAAGGCCAAGTCTCCATCCCAGAAGAAGCCTGTGTCTAAAAAAGCAGGAGGCAAGAAAGGGGCCCGGAAATCCAAGAAGAAGCAGGGTGAAGTCAGTAAGGCAGCCAGCGCCGACAGCACAACCGAGGGCACACCTGCCGACGGCTTCACAGTCCTCTCCACCAAGAGCCTCTTCCTCGGCCAGAAGCTGAACCTTATTCACAGTGAAATCAGTAATTTAGCCGGCTTTGAGGTGGAGGCCATAATCAATCCTACCAATGCTGACATTGACCTTAAAGATGACCTAGGAAACACGCTGGAAAAGAAAGGTGGCAAGGAGTTTGTGGAAGCTGTCCTGGAACTCCGGAAAAAGAACGGGCCCTTGGAAGTAGCTGGAGCTGCCGTAAGCGCAGGTCACGGCCTGCCTGCCAAGTTTGTGATCCACTGTAATAGTCCAGTCTGGGGTGCAGACAAATGTGAAGAACTTCTGGAAAAGACAGTGAAAAACTGCTTGGCCCTGGCTGATGATAAGAAGCTGAAATCCATTGCATTTCCATCCATCGGCAGCGGCAGGAACGGTTTTCCAAAGCAGACAGCAGCTCAGCTGATTCTGAAGGCCATCTCCAGTTACTTCGTGTCCACAATGTCCTCTTCCATCAAAACGGTGTACTTCGTGCTTTTTGACAGCGAGAGTATAGGCATCTACGTGCAGGAAATGGCCAAGCTGGACGCCAACTAGGCTGAGCAACGACAGAACCAGCTGCACCATGTACCCCACCTCCAATTTAAAAGAAAAAAAAATCCCCTTCACTCCTACTGGGAGGTGGGACCCCTTTCATTTTCAGTTTTGCTCATCTAGGGAAAATAAGGCTTTGGTTTCCAGTTCAATTGTTTTTGACCTTCTAAAATGTTTTTATGTTAGCACTGATAGTTGGCATTACTGTTGTTAAGCACTGTGTTCCAGACCGTGTCTGACTTAGTGTAACCTAGGAGATTTTATAGTTTTATTTTAATGAAACCCTAATTGACGCACAGCAGTGGGAGAACAGCGTCTTTTACTTGTCGCCGAAGCCAGGAAGCCCCGTTTGTAACCGTGTGTTGTGGTGCTTTATCGTACACCCAGTGGCGTTCTTTTTACTCTAATGTTCTTTTTTTTTTCCCCCTCAGAAGAATCATGAATTTGCAACAGACCTAATTTTTGGTTACTTTTTGTCTTAATGATGGATTTGAAAATGGAAGATTTAATAAGGCAAAGCAGAATCTGTTGTCCTTAATTATATTTGCAATTTGGAATTTGTGTGAGTTGATTTAGTAAAATGTTAAACTG + BD>EECEC=?BCFA=CEG?EDG5DC=>D<'??=;AADBDFE/ED@EDCEDF@8FEDGB5CB;:BDBE?GAEDDAC>ECGGCF8FEB>BC:@B966GFDEDFGEB@G;HIFJI@F=DDGCD@=;IGKKEKH9JHF@JHBKFK5@IFK4HA=JIJKKHHGIKKIHKJJ>J7KJCHDH@KH@IKJIKKJGFJKKGE;JEJIKBKFEIHF?K=HJHCHFHGHGKFJ?J8G2JJKDHKDAHHKCKGKKI@HJE<FG>JJIHKKEKIJJDJKJJIIJCKKI>BGHJKKIKKJFGKCHIIJICJIIKKIEHIKKFGKKCAJJG=KKIKBDFJKIJ@JJIHJ?FHCEIFJKIK@KKKCKFJJFJBBBKGKIKFKFHKJ;K:KF5KKHC8JEGHJKKKKKGIKCKFJJIIJKJKKDCJIFDIHGKKHHI;IBIEJK1JHJKEIGHEJKKI*IE-GGKKKKKKIBIKKKKJFBDECGJ@IJDJDK@JJJHJKGGKFFI8EK?KKKKFJGKKJ=KKJKHJJGKAJHKKIKJH@KJI0FIKCAHKJJGK @rCer/625/25_1653_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTGATGCGATGCTTCCTACACATATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCACCTTCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACAACAGGCATCACCCTCTAAACCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGACGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGCATCTACGGTTCAACATTCTTCCTAACCACAAGGCTTCCACGGACTCCATGTATTATCGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGACCACACCACTTTCGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTTGTAGATGTTATCTGACTACTCCTCTATATTTCTGATCTATTGATGAGGATC + $+++1.-0*2100,02)/,/,-..'110.1-0-0-/-0&.,1&,#-($*,)+-,%/./0..%)"(*,.+()&0210,+00411(1-.21&00(11/21/0.12&2.2)+).-11,.--$3,0(013531(2-+*4401--64043,4114/*354/%/3124465630460503363643/2+010-/43/1233/36)550/4546%-1))40-),),/24503156416601'/03&/,(.6&4335062463./3*2(21411/&00641/1+,612611104./*321/4643-.2./0/523661.444$%2/-*/335245).243./03--410-*&/(11/224-334/22)50-.61*.+*,0205+34430,45652.15041546622222662'/5465-66552)2323664(1100+23.+/+00.322+$,246125044+2-)/14536366266663203-02+320554611151224326,0-2**32**425535.2314,51&02026(42.125+12.1.$3/01))%.,-51216.10/03/6322+(+0-21,/6)35544)3+/.0/4'-.3',33451-.35+3$*/062055534644534640545001$.12-)-.-2/4512644'0005463*56+10/52626234064-244324(5264*/)&-02/(*3/432/4/26425///135211*300+-$21/5//3.1//43/2*06+1/2.+*/0,)+6%-00*4142-64*5.-1//52024202&20+63/321+/+/3405,.+/53212'453.6&/2(//01/,45323/24126614324431526-34-63/512+44/.*/100626.52243,2)+144.5460-5635-/+,11/16661264615.060545624553+5516563325/10+.43(*0/45025*34+.44$,.00/)/,---%)**..)),-0.30321/)-+.1(*%-#(%$&&*+001/-114/0/435110.))00..-++/'*/.103001.%04/-0,14513643///$443210,-12351./-004145465..01$/.)(/.2-2/32*2511',*-.-)/,,(-*0,)1,&-+*.1*-,+'*+*),)%(.$,**/))+(/0.,+0+).-0/1,,)&,./+'++%,(,+-)#%,-,)-(++-,$))*()-.-)+)))(,-,,(&%))&%&+*'-+'(,--)---+$,&)'----*',*,+),.-,%))*+$,,+,-**,),),+-,+,$+('&+(&((()*#-(,,--*(((&'$((()(%))(%$&($&''($'(%((&(($%&'%()&%$&'&($('%$'((((())%((&))(&'(''()'&&()&%((&'(&'))($%')(%'%'%'(%((()%)($('%')%&)('(%(()('$&&()()())(%(()'(((('#%%''&($$'()$$(&)(('$&))%$&)(%(%%(($'(')%(')(($%'(')'(()'$((()'#&)#%$%)'(#%%%%&&&))($('%%())'"&')))')$(()(%(($#'$'(%(('%'&('))(%(%((&)((&(((%()''%#'$$$*')&*),),,'' @rCer/626/2075_61_CCS ATGGGGACATGCGCCGCGCCCGCTCGACCCGGGAGGCAGGGAGGGGCGGCGGGGACAGGCTGAGCTCAGCCCCCAGGCCAGACACCTGGCCGGGACGACCGCCAGGTGAGCGTCGCGGGCACGGAAGGGCTAACACGGGACAGCCCCACCCGGGACTGCGTGGCGCGCCCAGAGCAGAGAATTCCTCCAGGTCACCCAGCCCGGCCCCTGCCCAACCTCGGCGTTGCCATCTGGGAGATAGGGGTTCGCATCTCCCCGCTTCCTCCAAGCCTCTTAGAGACTGAGAGGCAGCTTCTGTGGGTTTCGGGCCTTTTTCGGGCAGGCGTCCAGCGCGGGCAGGGCCTCTTCCCAGGCCACTCGTCCTGTCCAGACATGCCCTCGGTGCCCGGAGCTCAGCGGTGGATGGCAAGGCGGGCACTGGGCAGAAAGACTGGATTGTCCACCCTAGCCATTGCCTAGGCTACTGAAACCCCTCCCCCCACTCCCAGAGCCCCCTGCCACCCTGCCTGGCCCTGCATATCCTTCACTGCTGTGGGAGCCAAGCTGGGACCTGCCCAGGTTATGGCGGAGGACCAGGCTAGGAGAAGAGACTGCTCAGCGCCTGAGTCTCCCTCCCCACGTCTTCATCTGTATATAACGGGGTGAGATGACTGTTGACATGGATGATTCTGGTCGTAGATGATGCTCCTGGTCTCATTCCAGCTTGGGCTCTGTGGTGAGCTGGGCATGTTCTGTCCAGCCCTCTCTGAGCCTCCATGGCCAGCTTTGCCCCTGGAGGCTCACACCCACGTGGGCACCTGCAGGCTTATCATGAGTCATTGAACACACCCTCTACAAAAGATCTACTTGAACCCCAAAGATTGCTGCACAGTGAGGAGTGTAGCTCACAAAGGCTGAGGAAGAGTGATACCTGTTCTCTGGGGGTAACTGGCTGTTTGAGGAGAGGCCAATTACATACTGAAAGGGGTGAGTCTAGCTGGCAGCAGGGAGAGTGAGGAAATCCATGTAATAAGGCCCCTGTGGGCATTGGGTTTACTACCCACTACACCAGTTTACGGATCAGGATCAGGAGAGTAAAGAACAGAGTGAGACGGTGACTTACCCAACACCTACAGTTAAGCCTGCAACCCCAGGTAGGCATGGGGTGGACAGGAAATGGCACCAGACAATGGAGTCCACTCAATTTCCGGAAGCATCCTGCTTACTCCCTAGTGCTGAGAGTAGAGATTTTGCATCCTGGAATGTTGAGGGCCTGGGCTTGGAGGCCCTAGACAGACTCATCTGGGGTCTGCTCCAAAAGCTCTGACAGGGGCTCCTGTAAAATAAACTGATAGAATTTCTGGGTGGGTCATGCAAACCTAATAAGGTCTCAGCTTCTGCCATTCCCCTGCCCCCAGGACCCAAAAGAGACCCTTTTCTTGGAAAACAGGTGGGTTGGAAAAGAATCCCTCTTTCTCAGGTGCTTTCATGGGCAGGTGCATCGTGAACAGTGATGGGACCACAATGTTCCCACACTGCCCTCCCAGATCTCTAGGGATGGAAAACAGTTCTCATGGGGCTCTAAGGACAGAGCCTTCCATCCAAGGGGTGAGGAGGCAACGCTGGGAGAGTCCAGAAGTTTGTCTGTGTCCAAGTCTGTGCCCTCAGTGTGTCACTCCCATCTCTGGCCCCCTCCGTCCACACTGCAGTGACCATCTATTGTTTGTGCTTGCCCAGATTTCGTTCTTCCTCTGCTAAGAGCCTGATTTTCAGGGTGGGTTCCGGGACTTTGGCTGGAACTACTGTATTGGGAAAGAGGCACCCTCTCTCTGCCAGCAGGATGTCTGCCTAGAGCTCCAGGTAGCCTGCAGTCAGCCACATGGAAGAGCCAACCCAGAGGAGGCAGAACCAATACTTAGACAGACAGATTCCTGACCAAATTCACAAGCACCTGGATCCAGCTGTGCCTGAAGCTAATTCAGTTACATAATTCTATCTACCTAACACATTCTTCTGATTAAACAGTTTCTTCCAC 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rCer/628/1998_55_CCS ATGGGGACTCCTTTGCGTGCTATCCCCGGCGCCGCGCGCGGCCACGGCGCTCCGCCAGAACCGCCGCCGCGGACTCGCCGGGAGTGGGGGTCTCCGCTGGTGCCAGGCCGCTTCTGGAGACCCTCCGCCTCCTGCCGACTCCTGCTCTTCAGGACCATCATCCTTAGTACAGAGGATGGAAAGCTGATGCCCAGTAAGATTGAAGATCCATTCTGCATTACAGAACTGTGGATTATCTGTGGGTCCTGGTGATTTCACGTCTTCATTCGCTCCTGCAGTCCCTGGACACTTACTGGGGTCCTCATTGCCCTATCTGGTGAAAGATGGCATCCAGCCTGACTGTACTGGAGTAATCTGGGCTTTGCTCTCTTTTCTTTGTGCTGCCACCTCCTGCGTGGGGTTCTTTATGCCTTACTGGCTCTGGGATCACAGCTGGGCAAGCCTGTGTCCTTCGGTACCTTCCGGAGGTGCTCATATCCTGTGCATGATGAGAGTCGGCAGATGATGGTGATGGTGGAGGAATGTGGGCGCTATGCTTCCTTCCAAGGCATCCCAGCGCAGAATGGAGGATCTGCACCATAGTGACCGGCCTGGGTTGTGGCCTCCTCCTCCTGGTGGCACTCACTGCCCTCATGGGTTGCTGTGTTTCCGACCTCATCTCCAGGACAGTGGGAAGAGTGGCTGGAGGAATTCAGTTTCTTGGGGCTTGTTGATTGGTGCTGGCTGTGCTCTCTACCCCTTGGGCTGGGACAGTGAGGAAGTCCGGCAGACTTGTGGCTACACTCTGGCCAGTTTGACCTGGGGAAGTGTGAAATCGGCTGGTCCTACTACTGCACGGGAGCAGGTGCCACTGCCGCCATGCTGCTGTGCACATGGCTGGCTTGCTTTTCAGGCAAGAACAGAAGCACTACCCATACTGAGATGGAGCCACCAAGAGCAGACAGAGGAGAAGACGGACTGAAGGGCTTGGAGAGGTCAAAACATCCACCTACCTTCAAAGGTGGAATAGTAGTTCTAATCCAATACAATGCTAATAAAATGAAACCCGATAAATCAGGAACATGAAATAGGAAGGATTGTAGGAGATTGTGGGGGAAAAAAAAGGAGAGTGTAGAATGATGGAGAAAAATGGACCAAAGCCTAAAAATATTGCAGGGCATGGGTGGTTCTATTCCACAAAGTATTGTTAATACAACCACACACACACACACACACACACACACACACACCCCAAATCTATATATGCAAACAAGGGTTTGGGTTTTAGTTTTTTGTTTGTTTTGTTTTGTTTTAGGTGAAGACTCAGAAAATCAAAAGGGCTAGTAGAAACAGTGTTATGTTGGGAAGCAGGGTACCCCCAAAAATGTTCCTGTAGGTCACGGCACTCCAAAAGCACACAAGCACATACAGACATACGCATCCCCACACACACCCATGCACAACGTGGATCATCGCACAGACTTTACGGGAGGTTTAGTGGTGCATTTCTCCTCTGTTTTCTTTTTAATATACATTTAAAATACAGTATTATCACTTTATAAAGCATATATTAAACCCAATAAATGGACCAATAAGCCAAACTATCAGTATTTTGTATATCTGCATAAACTCTGATGTAGTTCCTCAACGTATTTTCAGTGTTTATGCAGACCTTTAGAGTAAGCCTTTGTATTTCCATGTTATTCAACAATATGCAATATTTCTGAGTAGTTTCTGCTGTGATATTCGTATGAAGAAAAGGGCACCTTTCTGTCCACTAGGAGAGAATTCAGCTGAAGATATGAGAATAATGAGAGACATTTTCCAGTCATTGGATCGTGTTTTCTTTTGTCCATTATTGTACTGTGCTGTACCACATTTATTTCTATATTCATTTTGTAAAAATTTAAAAGTGCTATTTTGTTTGTATTTGAAAATCTCTGTGAATAAATTCTCTCTTTGAT + DGHKK/@8DJDJC9F6BGDHCDIK>=-:59;0*5:;GADH?D=GGG8;IJJA4EICFFIBKDCJH<@>FCK8GCDIJB9GH08BHHJGI1<9CB-FC=?4>?H5GJJK5B@H.>BC8*?DGG(CGGBE+@E?'3F7<>=8D0E<;?B/?DF5BBG07:0D:E=-=AHG4BEBH2GHGE<=,8/6@@BG>EFFA=B87DEED67GGHJC>J:DB0;:5;;)<>(>D2EIFEF<=?@>E>JA?@I=;HBB9E,FC37$<>@ACH6:B<@?EBGHH=8>C.E?C74;;=:'8:?%8@>B@GH=H=7CDDH>;6?IFI=G6):7C<>=FCCC;58'4>9D<>=.9>6E>BA;?9=88D8@=AFED?@?EFCD4;FBI>97=A?=@>F7I@G9C0>:ADC&9:68D>>E,EHI:I>FIC?FEF;;78EI0IK9KH>IHIB5HBG/6JHGIG-H==GCHICFGBH@CF5EFHFCJA5C6-=*FJ;FJIECD2J2K@DH;EJ=AKDHGJ(:C:EJ9>CKIK9CDCHJCFFF<@+7DD@G>@KK*G=IK=IHKJ5EI6IGD9FIIDIFKDIE7CF@&39K@ICBDGH:A;C4CGH?%I=@D?EAGE6IHK>?CC=CG5DJE9?EADEDACH4DCGDJ@BKKACGFD@,FK;HDIE8IEAEJHEKGJIG);7I8ECCF&C9@D9>C@C?JII>G>F7=GEBJBC-E6;$?J1I+;82G>@@J4H=KEI0K6HDGI->EGI6;H1G;J5I5EII&,+>J6K2C?FA7:C?HCKBFF?@;:=CE8ACC@E,8<@C,;>IJ3KK;CDGDA%DCAH1F5BIFFIC,0@J4K?H(IF&:>BKFJE?B'10@BE?+294;?EH$2&72)DEF4==HA;I72@97GH#4>IH/:GDI*IGFJ7GI3?=J6CF-0GJAFKJ+FEGIH7EE8?8JGBE>HF-JHGA@E7GCAE(KH1H=HAIFI5=5HHIF)EKKK)17H8I33H@GI4EGIFK@H?>1I&&BK(FAIEIIE9@&EH6F35IF6:GCDGJKBGIEII;CG.A0@>D>#8JH0JKK0FGGFJAAD?GJJ>HCHHE4=;46IEI2B=;;:CG1D;@JFEHH6KK3IG?C-=:CI9JH8DC?IE)K8JG=HBJB4>F4CE,;BCEI8>?6DFCH?=FADH8K6=KFC1FD$/;B1KK5BFHIG77*FJH+H->EI6K2IFIGKJJ>?A=?=GEDG/CK?AJFEBJJGHFIK0K@ACA4?F6G@C=6IKIKII47ACE*@>I??G<6C+IGCDCIJD@5FAE>3F:IKK8BJI8GC7EFDEJJ$9FHA?1@DF1BDCH)DE=A:DFCC4=HI4C=DCHFCAF)JHJ @rCer/629/1548_58_CCS GGGTCCAGGCACACGGCAAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAAGCAAATGAACAGAAAACAGTTTCAAAACTGTCACTTTCTGTGTGAGGTCACATTTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGGTGACACCCTTGCGCTTTTGCTGGGGCACTGCGAATGGAAGGCACAACAGCTGCAGAGACAGGAGGACGTGAGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCGAAGTGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAAATTAGCTGAATTCGCGTTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGCAGAGCCTCTACGAAACAACACTCGTTTCCAAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGGTAGGAGTTCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCTGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAAGCCCCACGCTGGCATTCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGGATGAGAGGGTTACAAAGAACAAAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGCATGGCTGAAACGGAAAGTGTACACTGTTTCCTGAAATTGAAATAAAACAATAAACTTTTTAATGG + &$"$"!"%#$$$%$$!""!"##$$%#%$$%#%$##$%$%%%%%"#%%%$$%%%$$%%$$&%&(#$&%())&%""#%#''&&#'(((&'(')&'&$"(''&)*+,**%#&$-(&&&&#(')(+&**&(--(')-+)--*+,)(+)'++.+)('')+#+*')+--,+%$'%,%$+&$$((##(+)($$#$''&')#)*(#)%'$%&,)#'-..++'+##'$+,&'#'('(,*-''%%(&'++*#)'))(+$+('(&%%"#+,('$''*('*(,&(+'++)*,,-'&$#')%%%(%$")&&)(,+,-+.+*++$,+'0/-,,-.-(++0-/,,+/-.-+,..---*+*'-$).)&,*)&(--(+,--(*+',)$(/((*+&+*//-)+$*)$&(,*(#((&**+'('**#+'*$)++-+,+.+)&$%&$)***&'*%%,,*(-)(#%%'$%''&%&&##%%$%&*%%*'')'$#"))'(0-*$%),+,/**(%),)(/10,/0/(1/,,,,1..,*+1('(--1*0/12-+./-+-..-*%+%-+-//1)'%.&,1.*,'-+**%$,'+,#-0,-.,*/))*01*-.--).2(*).0&12+,-,1/.,'*+-'0+).&)).1,,'))01,20+.*.*$+%%')(*,/1111%*.(),-,*+'++*%,'.0,-)++'+$&-,(')%/))&)/-/2+)+("(-&)'/./-/,(+,&%(#&*%#&+$)**($)%,*(&()/-,)*(+'&).,)-'&)&*(+')'%'()$+*))'$-(*+*+*),+,,1*%$$#,'0,/.&$&)..2-++/($#,.*-,)'%'+*(%&,,1012/-')$)..1-.,*)-.*$,+.+(,#0*//-.%'0(--%+)--,.()&0.0,1,+-.*,/1+-2+'+%'&.+/-*+,+.+-+%',+,-**%*/'/,--.0.01.-)$*-01-.+'))/11/,,-/.,.1-...-1--2(+./*+)$%').,-,&11-1.,*/,/1-011'*)/..-.+).,.$22--1/,*',/1-.1.-,++*1//-%(*,.&()00,-(+&.,/1%(+-*%$**'+11+-++++.20/1,(+)/,,%/-..0,)0/+,.0,,.,)--+/,,$-.111&)*,+-'-.,()-0-+.+1*2,-)-/0-(#,-)0./-.0'*(,-'$---+(-01&$'*-'-,).&/1,,*-+,+0)/0)*',%&(0,12/0/*&.0.*+0/*120./).0$/1,0120.-.+'.,1/0/&0.*,/+.)*2/-(-1/0-.))0,-.).%&&$())&0./(&+)'##++&*,..-.,-)-+&(+*-+++)+$,)*+-),+&(*-+,()($())(,,*$--(,-+*----,((*)(-*+)*(+((+$*(*,,*-*,),+'&&%,.+)+)))')%&%'((&'$'(#%''&&%'&&$'&&%()'#())&'&(((%((%((#$((#())))(%$$&()&%'$)%$((%&'%($$($$()('#$#&$'%%)( @rCer/630/2443_54_CCS ATGGGAGTCGCTGACAGCCGCGGCGCCGCGAGCTTCTCCTCTCCTCACGACCGAGAACAGTCATCATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGCCTCTGCAAGAAGCGCCCAAAGCCTGGAGGATGGAACACTGGAGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAACCGCTACCCACCCCAGGGTGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAACCCCATGGTGGCGGCTGGGGACAGCCTCATGGTGGCGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAATCAGTGGCACAAGCCCAGTAAGCCAAAAACCAGCATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCAGTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCCTCATACATTTTGGCAATGACTATGAGGACCGTTACTATCGTGAAAACATGTACCGTTACCCCAACCAAGTGTACTACAGGCCTGTGGATCAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTCAATATCACGATTAAGCAGCACACAGTCACCACCACCACCAAAGGGGAGAACTTCACCGAGACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAAGGAATCACAGGCCTATTATCAGAGAGGATCGAGCATGGTCCTCTTCCTCCCCCGCCTGTGATCCTCCTGATTTCTTTCCTCATCTTCCTGATAGTGGGATGAGGAAGGTCTTCCTGTTTTCACCATCTTTCTAATCTTTTTCCAGGTTGAGGGAGGGAGTATCCATCTGCAGCCCTTTTAGTGGTGGTGTCTCATTCTTGCTTCTCTCTTTGTCCCTGATAGGCTAATCAATACCCTTGGCACTGATGGGCACTGGAAAATATAGAGTAGACCTGAGATGCTAGTCAAGCCCCCTTTGATTGAGTTCATCATGGGCCGTTGCTAATGCCGGGCCAGTAAAAGTATAACAGCAAATAACCATTGGTTAATCTGTACTTATTTTTGGACTTAGTGCAGCAGGTTGAGGCTAAAACAATCTCAGAACAGTCTCAAATACCTTTGCCTGGATACCTCTGGCTCCTTCAGCGGCTAGAGCTCAGTATACTAATGCCCTGTCTTAGCAGAGATTTCATAGCTATTTAGAGATATTTTTCCATTTTAAGAAAACCCAGCAACATTTCTGCCAAGTTTGTTAGGAGGCCGCATGATAACTCATTCAAAAAAAAATCCTAGAAATTGTTAGCTCTCGGGACACTGGCTTGGCCCACTGGAGCATGAGCTCTGTATCTACGGAGAACTGGGGCAATGTTTTACTTTTCACAGTAAGGGCTACACAGCAGCTGTTCATCAAGAGTAAATATCGGTACAACACTAAACCTCTGGCTAGAGGACATATTCACAGTGAAAAACTGTAACATATTTGAAAAAGGCTTCTGGGACTTAAAATCTAATGTTGGGAATGGTGCCGTGGAGGCAACCTCCCGTTTTTGTTTAAAGGACCTATGCGTGGCATTCCTTTCTTTAAACTCTAGGTAATTAAGGCAGCAGAAAAGTAAATTGCCTCTAGACACTGAAGGCAAATCTCCTTTGCCATTTACCTAGAAACCAGAATGATTTTGACATACTGGAGAGCTGCAGTTGTGAAAGCACCATCATCATAGAGGATGATGTAATTAAGAAAAATGGTCAGTGTGCAAAGAAAAGAACTGCTTGCATTTCTTATTTCTGTCTCATAATGTCAAAACCAGAATAGGTCAGTTCATAGCTTCTGTATTGGCTTTGAATCAAAGAAAGGGGACAACTAAAAAATATCTTACGTTGGAGATGACAAATATGATTGATTTGAAGTGGAAAAAGAAATCTATTACATTAATTAAGTAATTATTCCCTGAATTGTTTGATATTGTCATCTAGAGATACGTATTACTTTTCTGCAATGTTATATTGGCTTGCACTTTGTGAGTATTCTAGTAAAAATATTATTATTAAAAATATATTGCATAGGACAGATTTAGGATTTGTTTAGGCAGTTAACATCTGAAGTGTCTAATGCATTAACTTTTGTAAGGTACTGAATACTTAATATGTGGGAAGCCCTTTTGCGTGGTCCTTAGGCTTCAAGTGCACTGAATCGTTTTGTATAAGAATCCAAGTGGACACCATTAACAGGTCTTTGAAATATGCATGTAATTAATTTCTATATTTGTAACTGCATGTTCTTGTTTTTTGATAAAAAATTATAAATGTTTAATACTGACTGAAATTAACAGGAGCGAAGATGAGCACC + 0+.)''/1/-*.,,,,'-*/00/0-,,1.,)441,11-'1++614/.4524+/134+00.+00..,.2+040162034)20.4,-+-/-13.1/.0-,*-#)/5/4*-0*-&--()104++0$00*/23331/3*3--00)+*%02,32.55333/24-23433//)-.'*,)2,*31+#321$+(36/*.224%231,2.53,.-51**/)+,.2/+/,-(/505*13/'0/5.42-/*/4///4*6...*04+22332-%/0'/20'545422/2521/,2-)/1.06-.4524/2-.+/*1/011)'-/30'*').41-6,*2)12414,/3611+.22.0./*+*)-1,*0.54'301+/,02351,24/))53432/-6-.5/43/1*0.3132111.6,-/1012530-1.3415)002320213-/1$./0-53/0*50.1-*)*(/63304.06-0/,-/002-564,--'1151012&1-//$)+//.)/0*415.434025-,&1303552)3/-,)05-00/.+)++2./00'10-100,.1,2/2----/*.,.).()/&'*,&,--/-#,1-,..)/*&,())110*10111,1-1100/-0./+1/.-+'),+),10(00*2.,*,,/-21*./,%+,+&/0-0-//.,+,)%*011+)+%().($+,)*-,1-.0211---10,,-%%((%*-,(--&+*,/-)0-0,2//-//.-.2-0&)&.).-/.11,10,*,.-,&-0/2000/)'%$)'01+/1'12--0(/*.0,*.**/*--)/22+/(/0-,12+2,110,/.+01*&+,.,&..-$/10)0,+/100)---/-(+-.).**'-0,011)..01)1(000,)(/0*-1-.,+*+*)01.0022.001'0-*/+.2//1...+..$/1-112,---.-10-1122.'0..'10,+)&,/-&)02-+0+,&/1.00/+/.)/10-2/.++&-0..0-/0/.,1*.-,1/*,,(/)'()$+2210-01-.1/%0/+0/0+,),,02+211201-/-*,/0-22,00/,/../$-*&&+&0,,-1,)./+0,,.+0-)'*%*,,1110,*//00+(0---0.+0-11-)0120/+.)2/-(-)*(,+&/-)/*,/-11-1//,.0.1/*+02(12*+0.+(.0*,--1,.)0+/,,.--2,/1-1.10/.*/.+--*,1*(.2.-00&)2*.1)'*&,*02*1.+0/)+///,,,-/-0*+0/0&.(,022*/*,,/0$-1*/-12--,,/+/)02,1),00*.-)021-,%/*1110**,*$(++(.)+.-./000,#(1/0-1.0-1+,/--/*0+./21+,/.+/0112.2*--+(/.2.*+..+.*.///)/,'0--#-1)-/.)0,0,.,-.(+)(-/'+,112+0.-+,/+%/1+-*.,)/+-/'/1+0011/+(-+/0..20.,,/,1+*00**/&.(10*.*&,&-&"'(*,.,-(&$'&(&%'))+,)#$'%''+,-),-,-..+%))++$-+(+(,,--(+'+%'+*$+,**''+($)-(,,()$(&,+'$"$(+',.,.*')*''***+%+--&,*+,+,,'++&++-,-((&'$)%((''**%,-(+*%+()(%-**'-**(+&,,)&**+#+-,)+,,,,($'%)+)()*$+,(,(')+%)**'%,(*%%'$))#&+',+***%,&&)+&%()*''%*)*(*'()-*()***+,)((-+*&$+,%*(()'()%%%&*$(('**+,('*,+-'(&'&%&&((#'('---,,,)((*-+,,))%+,*$)-,-,----.-*+$)++$,,)+&+(++-'$,,'(('#*++*)&$(+'(,%++(,(''&$+%$%*##&(,%*+,$++'+,+,(++$%((#$(*+#('*+,--%'(++-,,-+.+*&',&+*+##($&$)++-)),,+',+(*,-'&*+*$+-*&$(&+)&$**+%+')()##'*$,+'+#'+%*(-'+&*)*)+),*-,*%((&***#'+'(+(%()*$+*+,-*('*+,++(((%#&(&+*+-(*(()+,%*(''*+$(#+,$++,,*)%''####%*("$*("#'%&&*'*)&*,-&,,,-+**$,-,#&*#*(,$*#*)%&)'-+),-+-+%"+--+)((#),,,-(-('+,*'**-%,*&++&,.*)*&,&+)#'%&*+,&*&*,)&*(,#',+'*(+,,-*)+''+"+)#((*+--,+-++,****&)),(-(,,(&,*)#$&+&')'+'(+(,(,+,)+,--)+)+&$%&'(,,,,+''#"#*+$*'+,**+%++-'&$'+(((-+'+''))(#&%##&#'*)$")$%)%%&++,-'-(%#'),*+(,,-(*,.%+,-(#%,--(&()%%+(&+' @rCer/632/24_1488_CCS ATGGGGTGCCGGGTCTTCCTGCTGTATGAAGGACGTACCGGCTTCTACAGCAGAGCAGAGCTCCGGCCCGGACAGCCCGCTGTGTGGCACCGTCTGGAGGAACTCTACACGAAGAAGTTGTGGCATCAGCTGACACTTCAGGTGCTTGATTTTGTGCAGGATCCGTGCTTTGCCAAGGAGATGTCTCATTAAGCTTTATGAAAACTTTATCATGAATTTGAACACAGGTGAATCCTTTGTCCTGGTAGAAATCATTCTTCATGTAGTTAGACAGATGACTGATCCTAATGTGGCTCTTACTTTCCTGGAAAAGACTCGTGAGAAGGTGAAAAGTAGTGATGAGGCAGTGATCCTGTGTAAAACAGCAATTGGAGCTCTAAAATTAACATCGGGACCTACAGGTTACAAAGGAAACAATTGAAGATGTTGAAGAAATGCTCAACAACCTTCCTGTGTGACGTCGGTTCACAGTCGTTCTATATCTCTCCAGTAAATACTATCAAACAGTCGGAAACCACGCGTCCTACTACAAAGATGCTCTGCGGTTTTTGGGCTGTGTTGACATCAAGGATCTACCAGTGTCTGAGCAGCAGAGAGAGCTTCACGCTGGGCTAGCAGGGCTTCTCGGCGAGGGAGTGTTTAACTTGGAGAACTCCTCATGCACCCGTCTGGAGTCCTGCGGAACACTGACCGCAGTGGCTGATTGACACCCTCTTGCCTTCAACAGTGGCAACGTAGAGAGGTTCCAGACTCTGAAGACTGCCTGGGCACAGCCTGATTTAGCAGCTAACGAAGCCAGCTTCTGAGGAAAATTCAGTTGTTGTGCTCATGAGATGACTTTCACACGACGGCCAATCACAGACAACTTACTTTGAAGAAATTGCCAAAAGTGCTAAAATCACAGTGAATGAGGTGGAGCTCCTGGTGATGAAGCCCTTTCGTGGGGCTGTGAAAGGCAGCATAGACGAGGTGGACAGACGCGTCCACATGACTGGTGCAGCCCGAGTGCTGGATTTGCAGCAGATCAAGGAATGAAGACCGCCTGGAGTTCTGTGCACGGATGTGAGAGCATGGAGATGCTGGTGGAGCACCAGGCCAGACATCCTCACCTAGGCCCCTGGTCCCTGTCGTGTCTCCTTTTGACCACCTGAGAGAGGCGTTTGCAGCCGATGAAGCTGGCTGCTCAGACGTCGACATTGAATTTGGGTAGGGTTGGATCCTGTCTGAAGTACAGACTTCTTGCTCTGAAAACAGATGTCCCTGTTGGGGCCAGGCACAGGAGAAGACTTCTTTGTGGGTCTCTCCTGCAGTGGTGGGGGTCTCTGGGTCTTAGTGATAAGGAGAGAGAACGCATGAGGCAGGAAGTCCCTAAAGTCCGTGTACTCCAAGGTTGATCTCCATCCCCATCCACTTACGGAATCTTTTCCATTGTGGTTGAGAATGTTCTATAATAACAGCTCTGCT + &+',,*('#$"$%*+)-&&),)$%$#%(,.,+$)(++++#)*)(#)'*&()+++,%011,%+&&$0#)+,600+/(-261/,(,,$(*+&-,512-42+3361524)3653464)0*3341)/-*/.15502621246,1*020505/,)465..465/33-*)./45+6.)(426+1.),+(-.02206/1/4(55025.6641(22/35-#+*0,541*.24+0(41,-5-25)4201$21+4112/06+,-/63161,0./.2,2-/'$$%+.(+#//24'.-)25650643))41)&,),,0&0'423310.12054/06*0/1(544455*55-2(2/35-(/523,/555)/%00.0/16265616/01451*22534&//123*014%14255,55665-65-1+43300.1640*1-/'2/&1*&3453550)2/+4()..&-1*+-155204424+325530/21&005.(#().04544)4*12.21013..2/*3/0022+21++1++*..*541.1.*)/201+%*,,(,,+0)4555(343656456651131*.*-0/(/253150534.11//0165'12304.%3621')05+543+1521)2),,3+01*0214-43.','$/-)0.#0-3254640.54.040+0+1,.0$1440+2'2325-5+/1)0232-*)032146-250.1/.(3*32,+%#*05003.54451)54+0,05+.32021/51/4-4,1*21(00256506.%&%$$#(,',-./+543%/12233655,5/./020-11142-.&.-0/3546162/4244+/1+.%-,,0-21002.)*,.$(-+0(.)054450244/2/*12*%433-4(+4346400'245//+1/#--,./250-3636,15062-0,.-///0&+(%..),+*'0%%1/)'+)0,.*)$*.'/'&143(312)(0103+45*123.+*,-+,3'4/%0/0(#,&.,022.%43/5,-500&.41661/,21+04)'-/*1152524'&$+.'02)--)+442*261.0*550323$26506/16254252/+-63610/1141/4*2/$,,-1),*)-+0.-$2+2601%+-)00++($,/3332)*'/555211036110)/.0)354.22330..625/4.00-.(215+565/.3,$266516-3513061.022*&+&*3$3'0/451554246562(,4.%#,$.22*-1/5*5553-$'$.-&*-.1)4$-00#''%'#)('$54226&20)3-+63,,&0.-,-.0+/---0&*%-*'/+)+/1110+01*%+21+0-01())(+.,,%,/0,01+/10-0+-&(%-)(#'*"(22,.-10(/-0*-,*//,1/2(//.&./-0)1/11.+**)'#))'*+#,()*..-.-+-)#''$-''')-(+)+#(-,()+#&')*,',,-,$ @rCer/634/1615_57_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGACTCGCATGAAAGGCACCACGAGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTGT + 1DCC<(J:JHHGF>?AEE'>DDD>=8KDKHKHKJFAK?FJH,KK1KGKGJJHKJIFDJK.HAGKJJHKEKJKIKKK9JIJFGKBJJIKKKKKCKCI*KDJKIKDJKKKKJKKKKKHJKKKK?KKKCKK@KE5KG;FJJK%KJIKK+KKKKKKKKJ/JJKKK8K@JKKKJKKK/JKKKKJKK1IKKKJKKIJKEI1KKGIKKKKEKKIJKEKKKKK@KKKEJJ=HKKKDKCKK5K;KKJ)IKKBKCIKJJG?IKKKK%-KKK1IFKGIKKK7@CIKKKKKK5KJIKIJAJKDKKKH3H@KKKK0K3IGKK;K>KK0KKFIJ)KKKKKKKKDKICKKKKKKKKDCKJHKKDKKJK?KKKJKDCKJCKK:8KKIKKK8KKHKKKGKKKJK5KK>KKJIKKJK8KKKKKJIKKK+KKJK,KKK7KJK?GHFKFKKHKK9JKK%J0KGJKKK.JKI@KJGKJKAJ4K=JKK;FKKKGKKKKKKKK8EJKJKKKKKKKK:KKKK3@FKCKK>JKKKKJIFKKKH?8KIKKFICD5JCGJAKJGKCKDJKIKFIFKC@?CCHKKEH?KBKKKK6HKKKFJ1IKKK(K.KKKK:IKH@JKKK>KKKKKKJK=IKEKK?HK=JKHJGKKJKDJKKIBKHIF8J=J2KJKKIKKKFKJKKK4;EKKKIKDKKKKK1HKKKKKKFKKKKKKKKJK@IKGK8JKKKHKKKK>KJKIKBKIJKJHGKKGIKKKKK9JK7JKGKKKKKIKKKK@KK9DAJK2EKKKKJKK-KIJKKCIC@KK&CKIJ8KFK?KKK,HJKK%KDKKCKK:KK @rCer/636/2274_63_CCS GGGTAGGAGGAGGAAGATGGAGCCCAGCACCGCGGCCCGGGCTTGGGCCCTCTTTTGGTTGCTGCTGCCCTTGCTTGGCGCGGTTTGCGCCAGCGGACCCCGCACCTAGTGCTGCTGGACAACCTCAACGTGCGGGAGATCATTCGCTTTTCTCCGGAGCCTGAAGGACCGGGCTTTGAGCTCACATTCAAGACCGCTGATGACCCCAGCTGTCTCTCTAAAGTATGGGGAATTCCTCTAGACAATCTATCATTTTCTCCCCCTCGGTAGAAGATTTGGAGGCAACATCAATGTGGAGACCATCAGTGCTTATTGACGGTGGAGGCAGTGCTGGTAAGCTGCCAGCTCGACATGGACCCCTTCGAGAGCTGGGCAGTGAGTGTGGGATCGAGTTGATGAGGAGAAAACGGCTGTCATTGACCATCACAACTATGACATCCTCAGCCTTGGCCAGCATACGCTAATCGTGGCTGACACTGAGAACCTGCTGAAGGCCCAACCATCGTTGGAATCATCTCTAAATCCCATCCTCTTTCGAGGTGTTGGGATGGTGGCTGATCCTGATAACCCTTTGGTGTGGACATCCTGACGGGCTTCTTCCACATCTTACTCCTCTTCCCAGATAAGCCTATCACTCAGTATCCACATGCGTGGGGAAGAACACCTCCTCATTGCTGGGCTCCAGGCCAGGAACAATGCCGTGTCATCTCAGCGGCTCCCTCGACTTCTTCAGCGACTCTTCTTCAACTCAGCAGTGCACGAAGGCAGCACCTTGGCCTCCAGAGGTATTCCAGACAGGCAACTATGAGCTAGCTGTGCCCTCTCCGCTGGGTGTTCAAGAGGAGGGTGTTCTCCGTGTGGGGCCGTGTCCCATCACCGGTGGCGAGACAGCCCCACCCAATGCCTACACTGTCACTGACCTAGTGGTAAGAGATGCTTGGGGTGGGAGGGCCCCAAGGGTTTGCCAAGCTGACTGGGCTCAGCTCAGAAGCACTTATTGAACACTTCTGTGCTGGCCTAAAGGGCATACATAAAGATGAGAAGTTAATCCTTACACCCGAGCAGCTAGGTTCAATGGCAGAGCTTGGCATGAAAATGATGTCCTTGGAGCACTTCTTTGAAGAGGTATGTGTATTTGCTAAGAGTGGCAGCAGTGGAGGGGCTTCACTGATTAACTCTGCCCAGAAAGTTGGACTTAATAAGAGAAACGACATTTCGGTTAGGTCATTAGGATGAATTTGTTAGGTGAGAGAAAGCGAATATGGAAGCAATGATGCTTGAAAGTGCCTGGCACATCCGGGTCAGCAGGTGGTCTGAGTCCAGACTTTGATGTGCCATGAATACCGTGTTGAAGGCATTTGAGCCTTCAGAGAAGAGCAGAGATGCTGTGTTGGGGGATTAACCTTGCTGAGGAGAGAGATTGGGTTACTGATCAGGGCCAGGTGGCGGGGCATCTGCAGTCTCTGAACTCCTGGGCGTTCCTGGCCACGTTCGTCGGGTGGGAATTAAGTGCAGCTCTGCACTGCGGTGGTGGCACCGCCTCCAGTCATGGCCAGCCGTGGCTACCTGCCTTTATCTCAGGAGTACAGCATCGTGATCCAGCAGCTCTCAAATGGGAAATGGGTCCCCTTTGATGGCGATGACATTCAGTTGGAGTTTGTCCGCAATCGATCCTTTTGTGAGGACCTTCCTGAAGAGAAAGGTGGCAAATACAGCGTTCAGTTCAAGTTGCCTGATGGTATGGTGTATTCCAGTTAAAGTGGATTACAACCGGCTAGGCTACAACACCTGTACTCTTCCACTCAGGTATCCGTGCGGCCACTCCAGCACACACAGTATGAGCGCTTCATCCCTCGGCCTACCCCTACTACACCAGCGCCTTCTCCATGAGCTGGGCTCTTCATCTTCAGCATCGTCTTCTTGCACATGAAGGAGAAGGAGAAGTCTGACTGAGGGGCCAGAGCCCCGGGACTCTGCACAGTGTGAGACGGGGCGGGGGTTATTAGGATTGGTGGTTTTATTTTGCTTTGTTTAAAGCCATGGGAGAATGGCACAACTTTACCTCTGCGGGAGATGTAACACTGAGAGCCAACGGGTGGGAGTCGGGATAATTTTTTATGTAAGTTTTTCCACTTCGAATTGCTAATTGGCATTTTTCATATGTGCAGTCACTCTCATTTCTAAAATAAAGAGCGACGTCGCCCTTCAAAT + 1,'$*)&)+%%&%/+10,1)-/02/0)(($$).*(/.),1/12..-%.1)1*-00(01+.,0'-0&,2.,1,+*,+.*1-)-)+-'+---))))-)&%')#'),.'#',,*+,+,%,+,--,*(+-.*---,**,''(##)'#&'(+)****'))'&()*%'++),'()*,+(,..++&*,)*)*(-',+$')*&&+),,)&(')*%*,)#$$$#$#"#$)'(((%"(*#-,*,,()-("'#(($('#*-)#$+*%('(&++%%*-+(%%'"'($'#%$)-+)+(,*)('')''-,))&&$$'($$((%&""(&'%('%'(#'(%%#$$$'()((($(%(&'$%((&#%%'$#%"#+'#'&)-+(+),--.-*(%+)$%&*,*,+(*+-++**#)*))%$%+*.-,',*+&''*(,.*(*+&)')()-)'+&%#+&)+("%(%#&%(%&"*#&(%$)&,+,)(&&,+*(''&'((((,,+),++(+&'(*-')%%&$%%-'(#*+-)-)+$,+)%+)&')+#)*'%()*+(('+(*$+(*)'&'--(,,*&(+&'&)*%(%$('&,%()&*)$-)++#')-+*',',-+*(%"#""&+(-(&,+')*),)))'$%)$')((,+&))&%$)'*++(+(,$%*+-+,)%%&*#%*++%($(+('$)#'*&+,,'(,*'')$*,,,*-)&)),)-+**)+*+"&%(*&$)$),*+++',)-'$&&+(,&+,'%$$'+-*$$$,,)+(,,+,+)*-()'"%(&"',*%,,*,(&'$%$+%$#%*&(),+)*)+',$)**-,-)+,(+&,-,)&++(*)(%&$+++)%$'#('%++&')+(+)&$++(')*&'+*(''+&'''$,+,&-'')*%,+#%&%$*&,%)%%))&(,(&&$*+$,,)*'#(,+%+'(*+),,+()%,,)%%'+(*('(&))&%+'*,*(%&$**(#&#$%,-+'+(++%('&)'(*'*((*+,,,,$&),)(*'(((-+*($*-((%$+*&+(#&++#,)--++&*(*+*%)(&+)()),,+('),)&$&+&*&&)%%,)-'('&&%#%(*%#))'(("%$,,(*&$+%(+-+)%)('%&&''("*),*)*-,-$&&(+)-,-))+*#+*(*)*)+($'*++))&&,,+/+)$'--%,'/+%&--*-/1/')-+,-%()''$,(*.,-0*-)++.2,--%*/-,1,2(-//.-(*1*.)+0,+*%1/*1+,.,./'.-.-&/--1'.%)*.$-/',.0,''/0%+01-+-)'-*.,,,(#-)%,0,0,112-1000+0201.1.$-,1)*0/,1,$-)&++/),0'--,'&+-*-.%.)$(&,,,-)*1)&*.%'&*%#-*&'+/+/**)*++$)#+*,-+'%'')(,/++*+1-'*$*-,+&),#,,&&&0+.%,.0.+.)+,-0.,&*%,(#'%'-*+),-,+2*(--0+*-(120200().**0/&-)*),--('&,+)*&%+*(),0-,%,($-,2&**&---%/22%-%.**&.,/,0+*+/+'%#&$,,-%(.+,2--)%#&.*...++--,%)-0/0+1,0+-)0-%++%',+,(%(#(&*,+*/*+'-)10*$(+%/-.,(&+(('+-'++-/)01-++/-.).+/222,*+&,--0++'&,++'++$*(**'0,,.-+*.*.&))&&(,+0,/+1.0+%.,.(&+(%,(0-/.0+-%+/*(,))2/./.$%%/)/./1*+))*000*,+%+%#$*+-#$+-*.,0,,)*)/$$%*#,0)-+0/-+%+)1*-.1,1-0+//$&,%%(*(&-0++'+-0,-(*'&')*))*%/%-&',)%0)&&/0,,,+,+*'&-.+(*&%&%&-/.++*$)*()(+%,*,%+,),-,-***(,,),,,*&$'%&#%+.0#$%))($'1,,%/&)+-+,-,)'#()*/-&02//,*.-'(+&%&)*-+1.+)'%.1---+0-($/,/&0.*-.0/./(/+'(*+*',')+'+-*(#'.,+**+$.,+,-$)$+,))0/.-*+**10-00)-.//%001.&.((%*,&+//-++''-++&/.,++)&(++,(**$../.1--)+))/.00,++..&*'/.-+)&%%&'100,0-+)(.$--(')+,./')/.,),.**%')%/11(,11,+.(/+++*((/,1.-,-/$**-0-,,+-%+0*.,.)+*++.0.*02,+($'$-(/1-/,-'&.+.%%'(0*). @rCer/639/953_57_CCS GGGATATCAGTGAAGTCATTGCTCTCGGTGTTCCTAATCTCGGACTTCCAATGAGTTCAGTATGACCAAAGGCTCTTAACCAATCAAGGGTATGACAGTGGATTTGCAGGTGGAGAGATGAAATTTATAATGTTTATGATCAGCCTGGAGAGTGGTAAGATATGGCCACAGATTTATAGGCCAGTAAAATCTGGACAGGACATGTATGGTGATGATCTAGAGCCAGAATAAAACCAAACAGATTTGTTCCCGACAAGGAGTTTCTGGTTCGACCGTAGACAGAGAGGCCGAGAAGGACCAGTTCAGTTGAGGAGATCCTTTGGTTTGGACAAGTTTTTGAAGAAGCAAACAGCATGGTGGCTCTAAAGACCTCAGATAGCAGCCGCCCCAAGGAACATGAGCATGAAGGCAAGAAGGAGGAAGGAGTAGACACGGTCTCTTCATAGTGAATGAACTATTACCCATTACCCTAATGATGCAAGTCATACGGGGACACTTGTAAATGGTCAGGATAAAAACAAATCTGGGTGTCGGATCCAGCACTACTTTTTATTACTGGAGAATGGGGGGGGAGATAGAAAATTCTACTTTGAATTACTTAGTTTTTTTTAAAGAGTGGGTTGTGTTTGTGCTTTTCCCACCTTTCGCATTTATAGAACATGCTGCCCACATACAAAGTCAAGACCACTTCCTTTTGTGTGACACTAGTAGTTTGGGGTTAATATTTTGTGTAAGAACAGCTGCATATGAGTAAAGTTACCCCAACCACAGTGAGGAGGATGTTCACATACTGGAACTATCCTGCCAAATAAATTTGCCCCTGTTGGCTCTGTTTAAATTTGGAGTGGGCAAAGTAACCTCTTGCTGGTGCAACTATTGTTTCAAATAAAAACATT + ..()+*,()'+,*(,-),-'-)))'%*&,,*),(($$(),,,(+)-,,(,(%#%',&*''&+,'+((,+(,*,,*(#&&'(((%$((..,'(&$%----,'(**&)),-*,*(%$$(((('(#&$#"'$#),--('%,,,%$&)'+&+))&##)$"*$'('%#++*%#*+$&%((0)+/&-#351320&**3514-$',42//3/(,0*41(-1.3-32,'/65724)0;9:+0-53&4180+3&68088,7(,1'54)#.1$13:33/'+/2.10-*.33/8:5:2813/36,:035250.0641.%+0-**/616234$5.+1&:4623&17388)$'&-*%.&/7,8-56359003(87.-46*929&%18158552*)958:85&1093:3.13815/-2/5-.56:22.&&&6933/:9:/0(344,")-./0(,*2-3/362&&256-88'/&157*+3&0::15;912:65-3(-02*/4047-%&-01/,3283/28/66574242-77*1.+%40102'7-500(-26153662-83*'/-$*6*54.-&134389863689(699445543%4-768827197-624271301377863$20)632*17(8.14+2.(5-42675&77%,4154-$766983.0%75%.3632/686&/2,0028943851%4)5/(24.2/1)+'/-4/413/(',/3(38:,431(3.1&6*887'37587'3:28,3/-01%*0)05)00605536//2%3%9-150&-0.)%/-&+,,1,013010/(4.63/(0'5,//2*65-066///#2322('/0)'+))0.-0.*&.'44*1*./354*44-(,*1(5.43.()+#20+43-*,(()$.05+266534321%*+3$ @rCer/641/25_1796_CCS ATGGGGAAGTGGTTCAAGAGATGGGGTGAAGGGTGTTCACCGGCTCTTCAAGTCACCAGCCTTCTGGCCCGCGGAAGTTAAGCAACCGAGAGGTGGGCCTAAGACCGGAAGCAGGAAGGAGGGCGCAGGAAGCAGGGCGCCGCAGCCTGGCGTACGGTCTTTCCGTGGATCTGTTGGTGCCGAGGGCGGGATGGAGAAGCTGCGGCTCCTGGGCCTCCGCTACCAGGAGTACGTGACTCGTCACCCGGCCGCCACGGCCCAGCTGGAGACGGCAGTGCGGGGCCTCAGTTACCTGCTGCAGGTCGATTCGCCGACTCGCACGAGCTGTCAGAGCTGGTGTACTCCGCCTCTAACCTGCTTGTGCTGCTCAATGACGGGATCCTACGGAAGGAGCTTCGGAAAAAGTTGCCTGTGTCGCTGTCCCAGCAGAAGCTGCTGACATGGCTGAGCGTGCTGGAGTGCGTGGAGGTGTTCATGGAGATGGGAGCTGCCAAGGTGTGGGGCGAAGTGGGCCGCTGGCTTGTCATCGCCCTCATCCAACTGGCCAAGGCTATACTGCGGATGCTCCTGCTGCTCTGTTCAAGGCTGGCCTCCAGACCTCACCCCCCATCGTTCCACTGGACAGAGAGACCCAGGCACAGCCCCCGGATGGTGACCACAGCCATGGCAGCCATGAGCAGTCCTACGTGGGAAGCGGTCAAACCGGGTGGTGCGAACCCTCCAGAACACGCCGTCCCTGCACTCCAGGCACTGGGGAGCTCCCCAGCAGCGGGAGGGATGGCAGCAGCAGCACCACGAGGAGCTGAGTGCGACCCCCACCCCCTGGGGCTGCAGGAGACCATCGCAGAGTTTTTGTACATTGCCCGGCCGCTGCTGCACTTGCTCAGCCTGGGGCTGTGGGGTCAGAGGTCGTGGAAACCCTGGCTCTTGGCTGGTGTTGTGGATGTGACCAGCCTGAGCCTCCTGAGTGACAGAAAGGGCCTGACCCGGAGGGAACGGCGGGAGCTGCGGCGCCGGACCATCCTACTGCTGTACTACCTGCTCCGCTCTCCGTTCTACGACCGCTTCTCCGAGGCCAGGATCCTCTTCCTGCTCCAGTTGCTGGCCGACCACATCCCTGGCGTTGGCCTGGTCACAAGGCCGCTCATGGATTACTTGCCCACCTGGCAGAAAATCTACTTCTACAGTTGGGGCTGACAGACCTCCCGGAAGGAGGGTGTGGGGAGGGGCGGGCAGGGGCCCCCTTCCCTAATAAAACTGACTCCAGCAGCGTCCAGCGTGCGGCCTTTCCGTGCCTACCGGCCAGGCCCTGCACACAGCCCTGGTCGCCACCAGCGTTCTTCCCGGGACCCTCTTGACTGCGCCCTCCTGTGACGATGCCACTGCAACCCGCACCTTGTCACTGCTGGGCCAAGAAGCCTTCACTAGGAGTGGAATCCAGCCTCCTCTCCCACAGAAAGCGTAACTTCACCTCATGGAGCCTGGGAAGCCGCTTGCCTCGGCAGCCACAGGAGCGAACACTGCTGCTCTCTCGCTGGCCCCTGGTGAGGCAGGAAGGCTGAACCTGGGTGATGCCCGAACGCTGCCAGCGTGTCTTATGGCCGGGGCCCTCTGCCTGCCCCTGCTCTGCAGGCCGTGTGGCTCTGGCAGCCCAAGGCCATGGTGTTGTCAGCCTCCCTATGACAGAGCCTGGTGAACAGTGAGCCTGGCTCCCACGCAAGTGGCACTTCAAGCCCTGCATCCTTGGTTGAGAGTAAAAGGCTTTTCTTCC + @C'FH??CE@FG/DH5J@DGH>-HG68;)D)E=(#1<=49?,462=*CB5I<@G@=GFABI1D<>.G>GH>@%?3H?9JE5IG7=I+A9EEC66A7G4E>3GDCGH@,C4=:;8=CBE<4JEGF?:CGE9@EAI@F-CGCEDE.GC:@@G5FCE;@+=7C75BHFE5F.AH>D:E8H;=8?BDCIIB>F-@C@3=AC>GEE0:E7>;A>@8FG?GAF3:AGHGFG9DHC>?4@CDBFJFGII=;CA?CI.DHGJGJ4H?=>7GH9?.GFDIGAED@HBEF>ADEC5B+E99/AHCBGEI<;D8-ABB;>9=9>>==<>AIH?>6E;C8?2GH=;DHAIB1DC5:H.<9=?A6:8%-=B?JBHIF@(HFIJHADEB7ICJHGCBJBF9H>EDC=0IHB7GD:EBG7JJJJAI>9.=0A;@JAHHF>I0CAIIDHBJF>:7AD:@AAJ;=BC9$HH7;HE0H5?5EE:F8EH:@F=EGH6>6HI02D>?2E90AHDIF31HJIIE@:::H85IFEG=/JJI@H=2+JHE?8D>3>.IIE+A<>=*EB57<4:F5:>5AF@CBE)ECF?AAD0CDDB<8EIH@8#5@DBA+GFII?DHI=G@=?FJ@AGFADHCH'FCC>BF@E='CI?HEDICDFH=DD5FEHF7D>F;ID.3G>)FDE:;A-*FII?E?>GBFEAAA5C4GE;HG9BF@GF*D/H7@BI??3GD6AHG12<;GHJA@DHDGG?EJ=8FAB5::EGFAFB@I9JJGFFF;2JHCJC$@;4GDCE85GGFIE1FGGIIIGB;I<;HHEEIDEE9FICHGHH=B'@@FI>EJFA@@EIJH5CF>4:A869D@AHHCHJHFJCE7FFJ=F9G>D;@J5GHF/G@6AB6HJC5IFI&D?J-F7AGABBB/D4E4GGF?EF0;I::F/IGGE;GBGD?H5J:%FC2JBF7I9=DJ:?>(CCDE>C@A=-B@C@)AAC%A@BA;C=EG?9?72@BD;@EB@C3D4AC0B>A@+A1?BC?DF8D.A7AA;GE<1)?A>.E(E8FA1E1GCDF<:>?6-A>BCBED4DDCG;EGDBCC1EE,?;4?E4BE@A?:59@CGC?FBD@GDEEDAB(B+@EABBF9A@22D?:G6C@@G-9CD@BE9CFE;FE9G=@2AA;>@F2?B:7BABBE?&A1DCE<@D7=D,@B7=@2C8GBC58B:E96CD;?4>?;@BE;A3BAE=$C;BGEFDDE6@979A6D5BGE5EADC4BAGBE=GGDFEA==AAF6$>,BE=FA,CA?>:=FD>E*DDBGA67A@A/@=8@CF7GB-ED@?D87D1ABB?E>5?;@=F@;FBF>ABF8BG=:2?FAEBB2CC>D:.?GE?G:4GGEA?G1D @rCer/642/3319_59_CCS ATGGGGAAAGAGGAGCGAGAGCTCGGCGATGGCGCTGCGCCGGCCCTGAAGCACTGGCGCACCACAGTGGAACGGGTGGAGAAGTTCGTGTCGCCACTCTACTTTACCGACTGTAACCTCCGCGGCAGGCTTTTTGGGGCCAGCTGCCCTGTGGCTGCGCTCTCCAGCTTCCTGACGCCAGATAGGCTTCCCTACCAGGAGGCAGTCCAGCGGGACTTCCGCCCAGCACAGGTCGGCTGCAGCTTCGGACCCACATGGTGGACCTGCTGGTTCCGGGTGGAACTGACCATCCCAGAGGCATGGGTAGGCCAGGAAGTTCACCTTTGCTGGAAAGTGATGGAGAAGGTCTGGTGTGGCGTGATGGGGAACCTGTCCAGGGTTTAACCAAAGAGGGTAAGAAGACCAGCTATGTCCTGACTGACAGGCTGGGGGAAAGAGACCCCGAAGCCTTCACCCTCTATGTGGAAGTAGCCTGCAATGGGCTCCTGGGGCCGGGAAGGGAAGCATCATTGCAGCCCCTGATCCTGAGAAGATGTTCCAGCTGAGCCGGGCTGAGTTGGCTGTGTTCCACCGAGATGTCCACATGCTCCTGGTGGATCTGGAGCTGCTGCTGGGCATAGCCAAGGGCCTCGGGAAGGACAACCAGCGCAGCTTTCAGGCCCTGTACACAGCCAACCAGATGGTGAACGTCTGTGACCCTGCCCAGCCCGAGACCTTCCCAGTGGCCCAGCCCCTGGCCTCCAGGTTCTTTGGCCAACGTGGAGGTGAAAGCCAACACACCATTCATGCCACAGGGCACTGCCACATTGATACAGCCTGGCTTTGGCCCTTCAAAGAGACCATGAGGAAATGTGCCCGGAGCTGGGTGACCGCCCTGCAGCTCATGGAGCGAAACCCTGAGTTCATCTTTGCCTGCTCCCAGGCGCAGCAGCTGGAGTGGGTGAAGAACCGCTACCCTGGCCTGCACTCCCGCCTCCAGGAGTTTGCGCGCCGTGGGCAGTTTGTGCCTGTGGGGGGCACCTGGGTGGAGATGGATGGGAACCTGCCCAGTGGAGAGGCCATGGTGAGACAGTTTTTGCAGGGCCAGAACTTCTTTCTGCAGGAGTTTGGGAAGATGTGCTCCGAGTTCTGGCTGCCGGACACCTTTGGCTACTCAGCACAGCTTCCCCAGATCATGCACGGCTGTGGCATCAGGCGCTTTCTCACCCAGAAATTGAGCTGGAATTTGGTGAATTCCTTCCCACACCATACTTTTTTCTGGGAGGGGCTGGATGGCTCCCGCGTACTGGCCACTTCCCACCTGGCGACTCCTATGGGATGCAGGGCAGCGTGGAGGAGGTGCTGAAAGACTGTGGCCAACAACCGGGACAAGGGGCGGGCCAACCACAGTGCCTTCCTCTTTGGCTTTGGAGATGGGGGTGGTGGTCCCCACCCAGACCATGCTGGACCGCCTGAAGCGCCTGAGCAATACGGATGGGCTGCCCAGGGTGCAGCTATCTTCTCCAAGGCAGCTCTTCTCGGCACTGGAGAGTGACTCGGGGCAGCTGTGCACATGGGTTGGGGAGCTCTTCTTGGAGCTGCACAATGGCACATACACCACCCATGCCCAGATCAAGAAGGGGAACCGAGAATGTGAGCGAATCCTGCACGATGTGGAGCTGCTCAGTAGCCTGGCCCTGGCCCGCAGTGCCCAGTTCCTATACCCAGCAGCCCAGCTGCAGCACCCTCTGGAGGCTCCTGCTTCTGAACCAGTCCATGATGTGGTGACTGGAAGCTGCATCCAGATAGTTGCAGAGGAAGCCATGTGCCACTACGAAGACATCCGTTCCCATGGCAATACACTGCTCAGCACCGCAGCCGCAGCCCTGTGTGCTGGGGAGCCAGGTCCCGAGGGCCTCCTCATCGTCAACACGCTGCCCTGGAAGCGGACCGAAGTGATGGCCCTGCCCAAGCCGGGTGGGGCCCACAGCCTAGCCCTGGTGACGGTGCCCAGCATGGGCTATGCTCCTGTTCCTCCCCCCACCTCACTGCAGCCCCTGCTGCCCCAGCAGCCTGTGTTCGTACTGCAAGAGACTGATGGCTCCGTGACTCTGGACAATGGCATCATCCGAGTGAAGCTGGACCCGACTGGCCGCCTGACATCCTTGGTCCTGGTGGCCTCTGGCAGGGAGGCCATTGCTGAGGGTGCCGTGGGGAACCAGTTTGTGCTGTTTGATGATGTCCCCTTGTACTGGGATGCATGGGACGTCATGGACTACCACCTGGAGACACGGAAGCCTGTGCTGGGCCAGGCAGGGACCCTGGCAGTGGGCACCGAGGGTGGCCTGCGGGGCAGCGCCTGGTTCTTGCTGCAGATTAGCCCCAACAGTCGACTTAGCCAGGAGGTCGTGCTGGATGTTGGCTGCCCCTATGTCCGCTTCCACACCGAGGTACACTGGCATGAGGCCCACAAGTTCCTGAAGGTGGAGTTCCCTGCTCGCGTGCGGAGTTCCCAGGCTACCTATGAGATCCAGTTTGGGCACCTGCAGCGACCTACCCCACTACAATACTTCTTGGGACTGGGCTCGATTTGAGGTGTGGGCCCACCACTGGATGGATCTGTCAGAACACGGCTTTGGACTGGCCCTGCTCAACGAACTGCAAGTATGGCGCATCAGTGCAAGGCAGCATCCTCAGCCTCTCGCTCTTGCGGGCGCCTAAAGCCCGGACGCTACTGCTGACATGGGGCGCCACGAGTTCACCTATGCGCTGATGCCCCACAAGGGCTCTTTCCAGGATGCTGGCGTTATCCAAGCTGCCTACAGCCTAAACTTCCCCCTATTGGCTCTGCCAGCCCCCAGCCCAGCGCCCGCCACCTCCTGGAGTGCCTTTTCCCTGTCTTCACCCGCGGTCGTACTGGAGACTGTCAAGCAGGCGGAGAGCAGCCCCCAGCGCCGCTCGCTGGTCCTGAGGCTGTATGAAGCCCATGGCAGCCACGTGGACTGCTGGCTGCACTTGTCGCTGCCGGTTCAGGAGGCCATCCTCTGCGACCTCTTGGAGCGACCAGACCCTGCTGGCCACTTGCCCCTTCGGGACAGCCGCCTGAAGCTCACCTTTTCTCCCTTCCAAGTGCTGTCCCTGTTGCTCGTGCTCAGCCTCCACCACACTGAGTCCCTGGGGCTGGGGTTTTTGTTGTGGAAGGTTCTGGGGACTCCTAATTTCTGTTTCCCCAGCCTAAAGCAGGGATCAGTCTCTTCTTGTGGAATAAATCCTTGGATCAG + 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@rCer/644/25_1856_CCS ATGGGCAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCAAAAAACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACACTATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACTTCACTGTTACCCAACACAGGCATGCCTCAAGGAAGGTTTAAAAAAAGTAAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTTTGCACATTTCTCCCTGTACGAAAGGACAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTACAAAATACCAACATTCCACCCGAAAACAGGGTTTGTTAAGATGGCAGAGCCCGGCAATTGCATAAAACTTAAAACTTTATAACCAGAGGTTCAATCCTCTTCTTAACACCATGACCACGATAAACCTCCTACTTATAATCATACCCACATTAGCCGCCATAGCATTCCTCACACTCGTTGAACGAAAATTACTAGGCCACATGCAACTACGAAAAAGGACCCAATATTGTAGGTCCATGTGGACTATTACAACCCTTCGCTGATGCCGTAAAACTTTTCACTAAAGAACCCTAAAACCCGCAACATCTACCACATCCTCTATATCGCCGCACCCGCTCTAGCCTTCTTCATTGCCCTCCTCCTATGAACCCCCCTCCCATACCCAACGCCCTAATCAACCTCAACTAGGGCTCCTATTCACCCTGGCCATACTCAGCCTAATTGTCTACTCCATCTATGATCAGGATGAGCATCAAACTCAAACTACGCCCTAATCGGAGCCTTACGAGCGTCGCCCAAACAATTTCATACGAAGTCACTCTTACTATTATCCTCCTATCAGTCCTACTAATAAGCGGCTCATTTAACCTCAACACACTCATTACAACGCAAGAACATCTATGGCTCCTCCTACCATCATGACCCTAGCCATAATATGATTCACTCCACACT 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12/42.0305/4-04546/&4/,/6462-060'1/.+((.3((+&-*$2+%./--./(23-023.1*12351-125-210,,-)&2.014/*3405253532()$/020/)/-,+001../.232+00001321)+,5.223,1253(.33$-*,2044*0-.5/2'1-1+/41100'/116665113/33235460$2+&,0/"&%&*2121503&3+41-4)3,331,,1063,)-0/42+5*120//1)-#%'*.$-/262034*16/+3-+-,)0('(,+*--(((3,0&0/--$.332.211)/13.2111122464266/634+0&1.,44264'44/444546/)344246246+,3-2471,0,/34))/.,)$(20)(/3'&$'23/7805,37./)236/-&3((%636%42(79775367%632577'6587:74-990/6,3,$050,703*66305(665204342-777/4-43899467(.21725+'7686872458095)2/22585167/98,616613843;44497566,87774+69444815264584455966861532869+83001,1254:8168674-.612,)$/46986:4'./42.2355)791/:9,:547082.52463460:4869.465%+4.:33/2234:3,2206)39983.:893660/34431*-68275893/7%4.,754(0'6889453452(6(%326*5215(34.24)14220./0-51584.2(3370'31)231+11132-4833120%*.0162*-1.,4.*11-,1,1132-4153(40314..35.42*2,5+51014343640//.00.3-3211*435)+5,3.&-/-'3216361'/1/1-%/1/&.))0,43-/.//362633).2%(/.'1003022%0542*+/*/2/5.6650*+11523(,)543465+))+25-123/01(,+12/213,26612,6+1256-4*0223664655615,2,+136502/12/10.0%.541-5302(2134)0.164+/05,-+45/3246.$52.+33*53,/036561105,.1)2/.$%+*)1/26655&34/544(-5366543/5.6101(33)((44.-'+.312-1,0-1+/*#)562*/(.+&(%)(&+''0-*%01245-05,445/1342/0062465-&04#+514161310.225155/4664456(0/03345//1.60-2(-3220651206+0-1*044164643/*0/+.('1-2539/2%002365-211,,-4666566321146&+6'--044777&(*5359:4&:5:.28.535:*00+,-*.17894,2&31.+)23-/0(.*.,2++0.60/:/25:76633',046.8,60'445-3:862355-.:674,3358/350995+4'377*961,+431-54436,.-2.(+12758/+*033536/-3./00/3/52132*32/320+56.254300/7227825$.-./*,$01-.6(1,(633+430,0-1/41/2--2+1/%1334.2831814%0.618,32973366//68(+1:51,6748094'$4*%26663$($,,+38035+::818+8840352.370092/.820(623/6660)7634+08*333-.%2200.02-16435/1+(%4*32.+20,2783987+5341/33$,))/5-901,30354$)&()&,.-&1-%/00)31,321(2-1-/23+11324512365.)/2-341+3345/(-5%7*%*4&,2-'31632)/6.1$(*'/,(*0 @rCer/646/1807_58_CCS ATGGGGGGGCGAGGGCAGAGGGCGCTGGCGGCAGCGGCCGCGGAAGATGAGCAGCGGCTGCTCAGGGCTGAGCAGGGTCCTGGTGGCCGTGGCTACAGCCCTGGTGTCTGCCTCCTCCTCCTGCCCCCAGGCCTGGGGCCCCCCAGGGGTCCAGTATGGGCAGCCCGGCAGGTCCGTGAAGCTGTGTTGTCCTGGAGTGACTGCTGGGGACCCAGTGTCCTGGTTTCGGGACGGGGAGCCAAGGCTGCTCCAGGGACCTGACTCTGGGCTAGGGCATGAACTGGTCCTGACCCAGGCAGACAGCACTGATGAGGGCACCTACATCTGCCAGACGCTGGATGGTGCACTTGGGGGCACAGTGACCCTGCAGCTGGGCTACCCTCCAGCCCGCCCTGTTGTCTCCTGCCAAGCAGCTGACTATGAGAACTTCTCTTGCACTTGGAGTCCCAGCCAGATCAGCGGTTTACCCACCCGCTACCTCACCTCCTACAGGAAGAAGACAGTTCTAGGAGCTGATAGCCAGAGGAGGAGTCCATCCACAGGGCCCTGGCCATGCCCACAGGATCCCTTAGGTGCTGCCCGCTGTGTTGTCCACGGGCTGAGTTCTGGAGCCAGTACCGGATTAATGTGACTGAGGTGAACCCACTGGGCGCCAGCACACGCCTGCTGGATGTGAGCTTGCAGAGCATCTTGCGCCCTGACCCACCCCAGGGCCTGCGGGTAGAGTCGGTACCAGGTTTCCCCCGACGCCTGCGAGCCAGCTGGACATACCCTGCCTCCTGGCCGCGCCAGCCCCATTTCCTGCTCAAGTTCCGTTTGCAGTACCGTCCGGCACAGCATCCAGCCTGGTCCACGGTGGAGCCAGCTGGACTGGAGGAGATGATCACAGATGCTGTGGCTGGGCTGCCCCATGCCGTACGAGTCAGTGCCCGGGACTTTCTGGATGCTGGCACCTGGAGCACCTGGAGCCCGGAGGCCTGGGGAACTCCGAGCACTGGGACCGTACCAAAGGAGGTACCAGCTTGGGGCCAGCTACACATGCAGCCAGAGGTGGAGCCTCAGGTGGACAGCCCTGCTCCTCCAAGCCCCTCCCTCCAACCACACCCTCGGCTACTTGATCACAGGGACTCTGTGGAGCAGGTAGCTGTGCTGGCGTCTTTGGGAATCCTTTCTTTCCTGGGACTGATGGCTGGAGCCCTGGCACTGGGGCTCTGGAGACTGAGATACCCCACATTGTTGGAGAGACAGCTACCTTTCTATGCCCCAGGCTGAGGATGAGACGGGGCGGGAAGAATGGATCCCCAAAGCCTGGGTTCTTGGCCCCAATGATTCCAGTGGACAGGCGTCCAGGAGCTCCAAACCTATAGAGGACCCAGGAGGGCTTCGGCAGAGTCCACCTATAATTCTGTCTTGCTGGTGTGGATGGATGGACAGTAGATCCCTATGGTTGGGTCTCAGCTGGAAGTTCTGTTTGGAGCCCATTTCTGTGAGACCCTGTATTTCAAATTTGCCAGCTGAAAGGTGCCTGTACCTCTGATTTCACCCCAGAGTTGGAGTTCTGCTCGAGGAATGTGTGTAATGTGTACATCTGTGTCCATGTGTGACCATGTGTCTGTGAGGCAGGGAACATATATTCTCTGCATGCATGTATGTAGGTGCCTGGGGAATGTGTGTGTGGGTCCTTGGCTCTTGGCCTTTCCCCTTGCAGGGGTTGCGCAGGTGTGAATAAAGAGAATAAGGAAGTTCTTG + KHKKKKKK,KKKKK1KHKJKKKKKKKKKKKJKKKJKKKKKKKJKKKKKKKKKKKKKJJKKKKKKKKKKKKKKKKKKHKKKKKKKKJKIKKKKKKKKKKKKBKKKKKKKKKKKKKIKKGKKKKKKKKKDKKJKKKKJKAKKKKKKK@KKKKJKFKKKKCKKKKJKKGKKKKKKIJGIKKKKKKKKKKDKKKEKKKKKKJJKKKKKKKKJJKKKK;KKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKCKJKKKHKKDKKKKKKIIKKKFKJKKKK/GDKKJKKDKJHKFDGKBKKKEKK6KKKK;KKKKKIKKJKKKKKKKKGHKJIKKCKKKIKKFKHKKGH@JKKK6KHKGKEKKKKJIKKJAKIIKIJKKKKHKKKKFKJKGKKKKKKKKK=KFEFKKKKKKJIKIBKKKKKKKJJKKJFKJJK/=KCIKEKKIKKKKKKIKKKFJKKKHKKKJJKKGKKK9KKKJKKKKKKKKKKK?KKIKKKKK@KKHJKKKJKKKKCGKKKKKKJKKKJKKJKFKKKKJAEE;FHK@KHKHGGHHKHF@JBFJKJKKHJKKBHKFH?>92<:<>B9=AB6<;=672:=3>9:DE35CD;BFD@==)A25?C?:B98=@@D>9:-?6@9;9>4<9>2;=;?9?:;2:=>@C753;7818:855+17/(.+../05301034>3=/9BC=AD<<78733?AB@6)5<7FB?>228/<:=98@2@EE?C?FFH@I@D:>A;3?)<5=:=@631<-0;8><@<7AE?>:7EGA?GC/BBEB@D3:C=B==?64D4F8=<<3:/CCI?F;BHC6,6>E96=-::>984%CH=;GGIGF3EA8:>>=:C9<6256865:8C@=@9C:@;62426/)B9=3=728:;<;@.<424:344554=<46:9;@>;;=C2A:9;B6C<7A??8C?A=$:DCD?>D=0579*>@HFIJ?8B33;BC?/@5=HHEBD8AHDF@:A:7,;9HH:I=GB9=:?;AH8?8B6<<:0DC9=;8@:><%<5<(=;-<7;F7;>=C>?EDBG=B;:29689AC@:@>B@@?->9:7B5AG698:FD@D>@>989675$>DC=@8@B?*==I@EG;:@H>7>H?>@IHD?@<@?F48?=::5;FEC@;;=ACCEE<65.?6=9=58>=?:4:3/-@D>?67==?>;69:51DA+<1#?@4FAEE@4;ECC;=AA@?;B@>BA=G:CCC@69B;?E@?>=4HHE5F>AB<90386<2;;I6FA?=D4<9FE?><=E*.7);=>BF75>A=?7=A4,(H(CB8=<9B9:93/05;;?A=3?::GED@B7DF8B6B?>A:C4E?<;DIDEIEDA?D>?:HCCB6=?,C640975=??==8:3EDI7IIJH=E@61>*A<(<5@C3>D.9<<4++D;E=5ECBFCC<9FIA=6DC:EG=6>8/B>FGF@AEBGB;9/6A8@@8:@?<6;C;AFB@;-CA>=:,@B=?9066:7967A849@5;85;:9BB<:8@BBCD<68$<>>:?EDD4.DBFA=+6>>108AE52654#<7.3:8?B7<=29=;><2=<;7=@5;>?@A<=>:)43:=7;?0113<099?A3B;?;EB>B47B/@=B@@BE?D34@3AC8>988.>;6:;:;5A@>EF5<39:?B8<@C@:3EE2=?=@?4?98917;7@8><9<=CC=;08A;>:9.%-1%15-6;69,8:<@<->/?:6@@9A81;9;><<6@8==35,&=:7:,=491=<=>7>9>>33<@C:6/7A@@70<>=5;<+5165B78895=?948:7;;9<=.;>>>C@@AB@B2=A6>AC:94@<97>6>>?:4?9:7:7A>::@?CC9<5:=>@5<=1=>;,2?:-84:B8471<0<515::88;73/:<5?>647/6>=09?=BBB:>;;9;;8,8:@95;9==871;::5;<>@718<-BB@=>;;>:6>>7B=?B8=<.<5/79<9.3*77%;<;/=A9.B:=;<269@;<*6@2.5?896/88=938>8>-0439457237?7;25>286*=>,1<(949;29<,9=<:>=228723279:==-59-%;%89=):==692369)7,%06*<8=1:=>96 @rCer/649/25_1880_CCS ATGGGGGCGGAAGTTTTCCGCCGGCGGACCGGAAGTCGCTGAAGACAGAGCGATGGCAGTTCTGGAGGCCTCGCTCTGGACCGACCGGAGGCCACAGTGCCCCCGCGGTAGACCGGACTTGGGTGACGGGCTCCGGGCTCCGAGGTGAAGAGCATCGGGCTGAGGGATGGAAGGGTCTAAGACGTCCAACAACAGCACCATGCAGGTGAGCTTCGTGTGCCAGCGCTGCAGCCAGCCCCTGAAACTGGACACGAGTTTCAAGATCCTGGACCGTGTCACCATCCAGGAACTCACAGGTCAGCGAGACCCTTGGAAAGAGGTGGTCAAGAATGTGGAAGGTGGGCAGCTTTGGTGATATAATTCTTATGGTGGCTGTGTAGTCTGCCACAAACTCATCGTGTGAACCTAGGAAAGTCACTTCATCTCTCTGGCTCCCTGTTTTCTCCTCGGGAACATAAAGCATTCTGACACTGTGGGCTTCTGAGAGCATTCTGACCGACCAGGAGCGATGGCTCACGCCTGTAATCCCAGCATTTTGGGAGACCGAGGTGGCAGATCACCTGAGGTCAGGAGTTCGAGACCGGCCTGGCTAACATGGCGAAGCCCCGTCTCTCCTAAAAATACAAAAATTAGCCGGGCGTGGTGGCACGCGCCTGTAGTCCCAGCTACTCGGAATGTTGAGGCAGGAGAATCGCTTGGACCGGGAAGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGGCTCCGTCTCAAAAAAAGAGCTTTCCGTAGCAAAAGAAGGGTCCTTATTTTCTGCTCCTGCTGTTTCAGAGAAAAGGAATATGTATGTATAATAATAAATGATGTTTGTTGAGGACTTACTATATAGTATTACCAAGTGCATTACACATGTTACTTCATTTAGTCCCTGTAACAACCCCTATGGGGTACACCATCATTACATCATTTTTCAGATGAAGAATTGAGGCACAGTGAGATTAAGTGACTCACCTGAGGTCCAACAGCTGGTAAATGGAGTAGAGTCTTAAAGTCTGAAGAATTTGCTGGACATGATGGCTCATGCCTGTAATTTCAGTGCTTTGGGAGGCTGAGGTGGAGGATCGCTTGAGCTCAGGAATTCTAAGACCAACCTGAGCAACCTAGCAGAGATCTTGTCTCTACTAAAAAAAAAAAAAAAAAAAAAAAAAGCTGAGTGTGATGAGTGGTAGAGGCTGAGGCAAGAGGATCACTTGAGCCCAGGAGGTCAAAGCTGCAGTGAGCTATGATCATGCCACTGCACTGCAGCTTGGGCAACAGAGCAAGACCCTGTGTCAATAAATAAATAAATAAATAAAAAGGCCAGGAGTGGTGGTTCACACTTGTACTCCCAGCACTATGGGAGGCTGAGGCAGGTGGATCACTTGAGCAGGAATTCGAGACTCCATCTTAAAATAATAATAATAATCATGACACCCTTATGCCTTAAAAAAGTGAACATTTCCTTCATCTGATTTAATGGGGTGAGGAGGACCACAGATTCTTTTTGGTGTAAATGGTACTTTAAGAAAAATTAGGCTGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCGGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCGTCTCTACTAAAAAATACAAAAACTAGCCGGCGAGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCCGGCCACTGCACTCCAGCCTGGGCGGCAGAGCGAGACTCTGTC + E@'GABC:1KGK?4JKJ;JH?K:CE?CF0)%FAKJIJJIHKEKIJJCFIHIJKKHIJFIGJEHKIJHK8GCKKJGGD$GBGFEF)A6HI:>(C8BHHHK/JJKGGF=JFHFBIJH*F@C=IJ'J6?E>IIK=KKKIFIKHJJHB6H;JECHGAIIII7E6CBD>GIEE;HC@EKJ?FEGFIHCA1DD<#FB:?H>KKJCJFHGJIJHJHBDHHJFGHJK@HFFIFJ:GDBHGCH?DKKHIFJIIJJIJFKC7DECIEJH>GDHCJDHGKKHIKFGEGHCFKJJHKDEHJHIJFHDEI=KJKKDHJKKH6HHJJCHEG8EIJ7KKFJK*HJJJI@ED7A0AGIGCF7JGAIIGGFJGIG@?@JJJKIB5IJJIF:KKJH7I<>EGHJG&C@HJGKKHIJIHKAJBGHDFGJKIKKI?DBIDJGKKIKKEFJD:KIA&7;ACIKJ8JEJJB@F?CH3>ADFE=@EHAF4EGHF>H?@BE@'GIGIIHJIHGHGHHKJJJIJKKKIJGJHDIIFJA9JIJGK>JF;.7:D@>HC;DDCD;@3DFICDDCKJI:0KJAECHGHFBFKGICJIJKEKHCAB@FFEJJDDEJ;KJKKKKKIGKK?FJGK>JKKHKJJFEKKFKKF7KKFJJKKKDEI7IJGCJJKIGKF@KF>'KKKJDIDK9BECD3;HGIKDJHGGHF9FIIDIG6KIHFGHIKKJ0G=@/FIIJJ5KKKII;=JJDIJE>KKKKKEHKGKFHDIKE?JIJKIKJGK'HEG>9JE0JJBJ?AKHJJJAGJK1JHK4JKGGFDHJ1JJHBKKGGAGBKFJHGI@JJHKJ#KIE>KKIJAKJJGIKKJHKJDI.KJGKJ.KIKGGIJ/KJI'JJEHB/E@3KJ@J6JDBKJIB>HJDKKIBJFJ/IJ3D*HB+BFHHFIE9EGF,KJJKKF9I'GGGEKHJ@=7&HIG?(FHBIJ5KDIKEJJJ>A<@:DJJKJ>HAEE?KK'=B4KIFHKJBJ@KJBKIHJIIIJFFFIECFH7HAK4IHJCHGJKIKKFHDKI,FKD+GC>EKFBB9E)ICJHFIHCE@JIKE7C>JIE=JJJKKDFG(?JGHJ@B8:AGGKK>J:AIIFDIGJJBD;JJKJ=J7?JIJCBD6FGJJ;BK8FK>IKFFGJ/JD?EJ4CA>I:?KIHF1EIJKKEFJJJ=GFCEIG8ECF=ABGIJIJKHHGAKH9HG9H@@I7KJDKIJKIFKJFKFIJAJHG;E>EIIHFJEJGF=3CGJKA.JKJIEEKKKKKKHJKIKJEBK?IJGFKCKJII?JKBJKJJIJHKGKIJHJKKJK7FKCIKKK9HIHIHKJEJEK?JJJFKIGJKJKCJB/?KKKK1JJGJKKEKKHIKCIBJJKHJKKJHJJKIJJ5K9IJEKKIKK4JKKKGEAFJ@KKEJHDKJJIA?DIDKKDJBIAEKKBJKKK;KJGKKKGK?KIKJIKFIJJ,IJ8FIIKHJKJGI@,HKHH?KJI>GKDGK+KKGIIKEC:DC'CCJJ,IGKKJKJKKJDI@;HJ=5AHKKKKJGJEFJHAFJ4@JGHJICJAA?@AF=DEGKI4JKB>KIBKGBC;EBH>HJH;JIHKDFIECHIEKHKH?AJJJKJ;F9HG9KJ,8I?HHHGBJ?@EFGI=GJEF==JGEHFGK;J?HDHFI8?IGDIE?CBDE@CIA:?E3HJJ>FC$6JJ@HB?KBIHK;<2EIE@HK;D>@DJ8?I'GJI7BKFJJFHCEIHI?HDK5DF@JF?C2:BCH@D?B=GJ@KKKEEDI?3DK'HJ:FFBI(EHIKKKD=3JI$D:KBCC?GG:KIHAH:CGFKHHG8GBJJ=;D2HD5JJDJFH=JEJJC>KH)IJE&DEJFD9A>CIE:BJJIF>*J7IK=?FFIFEF8KKK@?C4DBGFF?IIKC@&A@?H$AHFF=D@HFK:FEEHI=G(>I6@@:JG?HJKGHJFK9@E7KEEHD>&HBHFHI?2FF9G>IIGFD7?FKCCHICKHGJFHB3AH:F7JFFGDJKHEEJHKD6HI=IK@>J7IA&>DHDEDKKIBC9H=C<@BKAJHKI+6;AKH4FIDDCF=:AFHCGFKH4KIIJJKKKEKE/F>8DFJCJKKJHKJJEIGKKEG@FGKH-?IIKKI@HCKGF9>)?KAI=HEKCGIHJEI@JKK=H@EI>?J@IFG?D:BGI9FJAE:DF>EFE/%?3HDEIKIKHEKJ6JCIKFGIGJJKHFJJJJJ;GK8JAIJHG78D,=59DDII.D@HCBFBG9@K7IFGH:KEF>CH?B7D,IHGKJJFC<4IJIIIII?@GJI.G1JKHI6IHKIFGE8HJEIJ:CDHGKDGIEG=E9:I?8JB>K=;HJKFGHKKKJKBD/AJ3JJ>GEHHC?AII2GCHFKJFAJJG*HFHIJGIKJK??BJIH?JIDJIEGHDGDHHFIIH4IKD7HDHFB8F@D0A=>>F9I=FG%@G@D?EGHEHBIFC<@JKC5FC=F6;GKJ)GHABJJJ>GB3I@GH?HF:IB=AEG:;C?BI6DCFDIHE>CDG@FAFHFCEDGB@=D>EHFDKFEKDJAEHDGKIAGIHDHIIJEI/EAJGCGHK>G@>IIEHCH%BGJICK=EFE6DJG>BGIDDG@HFE(ABFAIIFE(FH@JIHDHI8GGEG1A@HHHFC?C;BCE,EFHA?EJF:CFFHGDHD:<@DAHEBA?D&;7;;2DGF?B@GD7FIBHIGEE95B?E@AD@CE6GG>EBG87;=34%+95=A==(@>=6;A8=8=<@?A>?<7@60>989;;>5:>?7?8==>?=<2=9<:4-7(84=2:56+12;<8;;.6;<8:<8>>9;<7:-:48>8?76;=:=>>?>::2:153850246:7/0-)&.432((1'4-.546',7065270;:*2=6,5,72,44-&)67*5;<9::;,)9><8:=8>?C?>=4:?28;8:<76;?=>9978<>&6=C>=;8<-?;72+7=?A'8@=@@B<=A4?.6?(3::0<6;:>;@9>?;9.64445?==<9=<2>;280197:<>:<,4::=>:,:<9>2=409539==5>;676:89-64>>?;3=1;00:(<8(6:6738;3:?:;>:<1.78(7:)2>;/8:2=86<2185:089=4:8>::943-4<>?,72<9866.685:3==995556:9/8313>=7::/+**34*3>;;3822<778?<<:=:=;>==1>>0:;8879:9:793?<<0+2+?9;8'4<04=@?4A7>6=??97=69113=@;?-=9;>/=?@8; @rCer/659/0_1062_CCS ACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + &)JJJKJKJKJJJAKKCKJIKJKKIDK0HKJKJKKKKIFKJKJKJKKKG>KEGDII:/:JJCKHKJJIBKKKGKKKJKJKJBKJJKKEKJ?CJ9KKKHKKCKJFKKJAFAKJKK;KKKHKGKKHKFJFEIICIKK=KJKHJKIGIJIKKEKKJJCKKKJKGGKKKKIKJJKKHGJJIDKKFIGJKFKJKKJKKIJKKJJKJDKIJKIFHJKIHKCKKKFJHKHKJAGEK:3KJ=KDHK?KFHG2KK?KAKK>KKKIKJKKKKKJGK>@:7HJKJKKHK=KCGHAIIKHJIFFKKJHKKJJJKEKKIIIK>KJGKKJI@JKKKKEKJJIIKII@JHBJJEJHKKGKH?KJKKKFKIKKKJKKGEHK:KKKKKKKKHJKJKKBKJJKJJJCEJKKHKKKJKJJJJ3D=FJIKGK:D;KKKKCGJJGDJ>JJKIKKKHKKKHKKGKKJDE>JEJJKFJKAKKKKDKKGK;HKKJKJ;KKKKG;KCKJHFKKKKKFKJK;EKJGEHJAKKI,H @rCer/660/1591_55_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACACCCCAAAAATACCAAACACATAACTGAACTCCTCACACACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCAACACAGGCATGCCTCAAGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAATTTTGGTTGGGGCGACTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCAACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAATACCACACATTCCACC + F@@@$B7HFFBFI@CCJ6CEEBEE9G1KFICIJB=G;DFKBII5J@K8JDF;HIHHGK8GBHA@HC82AHGGBEJ3H<58:@AEIB@GHIK/EJJ6F?>KIEFKGAA?>=JDAGEHGJAJHHDDHGJKFK@A>EKED<<'99E5GBIKCEHID@I=BEIEH6?GFE69A:EHCEEB>:)67A0?@@=/D8AE=FG6C=ADE(85BA,@EH+AAC@G>E><9;6B:5>>9@6CACC+ED>:BA4;065BC4AA?C:A474>8@?FF@A<9?6<=@B@@?B83C8>6B>B:=AD?9'@C>6A@?*:>?99>AA/B/B><5558@;<>>/3:951185;<9;;;-68760)075'3==5?@@4B3::/8?8@C??56.;C??4A?7>@5.4>><>9?8;:?6;3.B4B<10:=?@8:1(#486:5>B<8-39;2?>.84/;=<4<@A<426<;8:53/*585563383355;:@?72@A@>@=:@6.685.97+89?23><<8+383>>(56@.;5>6:?A?,ACC;CC7@B@1:3>076?:C7?<*=;=A3?C@;@=A>86-:89?>@6>;2;A@-7<551,@9A60917<>39,7%**83;27%<=64B4=>3/&(;&?8@6<==@>9(AB@?>497?+<7??)7?9*3=-:@&78'4&+548?09=3:=@B)035=<:'49:7?=.5>@A6<&=8?=B;87=@5:AAC6<<=@<774$88;;>1AA><<63A@28<;;)?=:==866?=A-@*9:@:6>;8:96C?5>=:?A938=>2?:@<>6A3>;@8;=7;?=/@<529+?@>627887*='6</4>7;@58.9@>;07;;:A>,?7):2:;9'=>./9?3:>??C:<@-+>8=)7/29:2;;;A>3B?B,=?A4=8C>><<)5:6$67>90@:98>>8;=6;87428:;8A;A=@<:9;;&6';4*6=0==B=C957+:/.9,3?;AA6.7276.3;93:8:>=<<8;;:97@4397:A>;<56:7;:>90=%8A<98>;;:B8698>ABB*C<=>B=A;?8;>A0?CC@A79>274=;8?=;>:=?>7@9@>39<<6=8;72A>=>>B98707@>4@.C@B?>B=??'=<7:A5&.'A1@;50??=<(C>B?<)+0-82&8=7?6?=79(A698:=<49-7A-@8=<==:.83<>10>;@/=:@A<>B8B99/?@@ @rCer/663/25_1581_CCS ATGGGGGGGTGCAGGTGGCGCGCTATGGCCGCCGGGACCTGCCCCGCAGCCGCCAGAGAGAGCCACGCGGCAGGTCCGGAGGCGGCGGCTATGGACGGCGGAGCCGCAGCTACGGACGGCGGAGCCGCAGCCCCAGGCGGCGACACCGCAGCCGATCCCGGGGTCCCAGCTGCTCCAGGTCCCGCAGCCGATCTCGCTATAGGGGTTCTCGCTATAGCCGGTCTCCCTGTAGCCGATCTCCTTACAGCCGGGCGCACTGCAGCCGCCTCTCCCTACAGCCGATCTCGCCACAGGGAATCTCGCTACAGCGGATCTCGCCACAGCTCATCTGGTTACAGTAACTCTCGCTACCGCCGCTCTCGCCACAGCCGATATCACAGCAGCCGGTCTCACTCGAAGTCTGGGTCCTCCACTAGCTCTCGCTCTGCATCAACCTCCAAATCGAGCTCTGCGCGACGATCCAAGTCCTCCTCGGTCTCCAGGTCTCGCTCACGGTCCAGGTCTTCATCTATGACCAGGAGTCCTCCCCGGGTATCCAAGAGGAAATCCAAGTCCAGGTCTCGATCCAAGAGGCCCCCCAAAGTCTCCCGAAGAGGAAGGACAGACGTCCTCTTAAGAAAATGATGCATCAGGAAGCAACATGATGGAGGACTTGGGGAAAGGATCACATACTCAGTCCATGGAAGCAACGTCCCTGGAAGAAGGGCTGCCTATTGAAAAGGCCCGGCTGCGTAGCAGTTGAGTGATGCTGGTTAGCTATTAAGGTGGCCTGTTGCAGTGCAGAGTGCTGAGCTGCTTCCTGTTTTCTTCTGATTGCTCCTGGGGAAAACACGCCTTGTCCTGAAGAACAAATGGCTGTCCAGTTTATTAAAATGCCTGTCAACTGCACTTCCAGTCACCCAGGCCTTGCAGATAAATAATGGAGCATGCAGTGAGCACATCTAGCTGATGATAATCACACCTTTTCCCCCGTCTTTTCTGAAAAATTGTAACTCTGATCATATCAACATGTATGAACTTAAAATATGGAGAATGTTATGTAAGAAATGGTTTATAAGTTTGTTAAAGTACTTAAAACGTGTATCTTTTTGATTATGAATTTTTTACGCTAACCATTGTTTCTGTAGTTAAAATTGTTTTCTTGTGTTATCTTTTCTCAAAATTAGAAACTTTTGATGGAAAGTAGGTTGTTTTATTTCTGTGTGACTTTTGGATATTTGTACTTTTGAGAAAATTGTTAGCACCAAGTGTTTCTCAAATATAATTTTTTAAAAATCCTTAATAGGCTTTTAGCCATGTGCTTTATTGTTTTATCACAATGCAGTTTATTTGTAGTTTCTCTCTTTTCTCCTCATACCTATGGTTTTTTTACTTCTAAAATTATTTTCAATAATCCATTTTTGGCTTTCATTATTATCCTACTGGATGTTATGTGTTCTTTTGAAATTGTTTCTGCTTATACCTTTACTAGCAAAGGGAAAATAACAATTTGATGTCTATGATCTAGTGACAATAGGATTATATTGGAGCCAGTTGAATAAATTTATTCTTTCAAC + 1.'0+--034.-/)*'01.4311'.435.5314,4555611.44665.1-335/6520+-.34+6520/5/556236562-.1)345630/30025,/0',*2,-3//*),/1#*.1224-1(-1650.*)-45//32&134./0.:79105:488(/6/3-40-45-46695:6;:794169/727+1,.26:34:46/0&22)%3%67844.1,422081.13796884,033.12581:44:3139*536:8891849:194#)42,'330,7)25475755676;::65:4:;54859::3528:+85517882:00130-43019+746470+,3/.-5751742152,0/*$-011-213.-/-,151/7(35746(&03974*143-/3/57745-503/3.174::66::48:96:4-95277-355:98%51+47786810*.:/575160.22758(2014:8,84282521:92-6568-.4.8359989556;:759806:65:.37:96166(/8/'53842/7/75)15-9934:(798345192684,.16:58948;*67686(2265-013:69:070/0.44::253:4()74304/5...-2660))./543/6/224+14/83./)20*:9,37%56%&+03/235313367260633:17,647:8(2267-6647965345&.1002/:89.953;;;9;*89492)495/779:93;:766566948759987345991...2/6/9495:458186681656163203-33218178:,760528/975375.2178(67.(+*/..065:2;:2,:44&2.).2(159496581033623863107693:2:8714256156855;3168:89)+5707-798856655.586+2.*011526413&25-152225155046436650*44+050(*(35.'11++,1446661*/+342.(1,0(/+-*,30.0.-,0.566./30)11/44,3+02603*+32426/2/140*0-,1(.50+2$.(+/23($/2.14$+,0553/2)110)/*0*0+.-46130/0,55(),%/22/-+.5,)+-/63342+/1515203&1$011)+/&/1/,+-$.3)-005+542.41$-.,-+2%.331+654/1005/5445,)+++1,4642&/2.011/0000$/33461,3)1--1,1(232334'543041465+4424(4,0+.2401.%//,2/*2$/-442"%+11412141624)///264.2441356351254065&24441/5413.4146362-+200/440120/,21)11+-3/.54/..)*22,'-&/.,*0--*/214%355*4/%0/2/*4/-2(-5-(/322-5.%-23&$-0+/23'/*053564550402)1246,/3563%1-/6456610024/31311'33.23-54335)4*$424556052%52/04523/(.4'050/,*02'(12226216+/1.1.620/6+2-53/5111/*35546*-0/2)/' @rCer/664/25_1484_CCS ATGGGGAGGTCCAGTGGGTGCTGTGATCTTCTAGCATGGGGTCCGCTGGCTTGTCGCGACTGCACGGGCTTTTCGCGGTCTATAAGCCCCCGGGGCTAAAATGGAAGCACCTGCGGGATACAGTGGAGCTACAACTTCTGAAGGGTCTCAATGCCAGGAAGCCTCCCGCCCCTAAACAGCGTGTTCGCTTCTTGCTGGGCCCCATGGAAGGCAGCGAAGAGAAGGAGCTGACCCTCACAGCCACCAGTGTACCCTCTCTCGTCAACCATCCACTGGTATGTGGACCAGCATTCACCCATCTCAAGGTTGGCATGGGACATCGGCTGGATGTCCGGGCTTCTGGAGTACTTGTGCTCGGCGTGGGACATGGATGCAGGCTCCTCACCGATATGTACAATGCTCATCTCACCAAGGATTACACAGTGCGTGGCCTCCTTGGCAAAGCTACAGATGACTTCTGTGAGGATGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAGCTGGACCGCATTCTGGCCATGATCCAAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCCAACCTCGACCTGAAGACCCAGGAAGCCTATGAGATGGCTGTGAGAGGCCTGATCCGGCCCATGAACAAGTCCCCAATGCTGATAACCGGCATCCGATGCCTCCACTTTGCACCTCCGGAATTCCTCTTAGAGGTGCAGTGCATGCATGAGACGCAGAAAGAGCTGCGAAAGTTGGTTCATGAAATCGGCCTGGAGCTAAAGACCACTGCTGTCTGCTCCCAAGTGCGGCGCACGCGCGACGGCTTCTTCACGCTCGACAGCGCCCTCCTGAGGACCCAGTGGGACCTGCACAATATCCAGGATGCTATCCGGGCTGCTGCCCCCCAGGTAGCTTCAGAGCTGGAGAAGAGCTTGGGCCCGCAGCTGGACACCAAGGAGCTCCCCAGTCGGGAATGGTCCTGGGAATCCCAGGGCCCGAGCTTTACCTTGGTGCCGGAGAAGGGTGCAGGGCACTGAATGCCCAGGCAGCTGCTGGGGCAGTGAATGGATAAATAGAAGAGCTGCTATGAGCTCGACCTGATAGCTGTGCAGAAAGTGAGAGCAGGAGCACCTTTTCTACGTGTGACACGAAACTCAAGCTGTAACAGAAAGATCAATGGACTTGACCCAACTGAAAAGGAAAAACTTCTGTATGGAGGAAAAGACAGTAAACAAATGACAGACTGATAGAAAGTACTGGCAGGCGAGGCGTGGTGGCGGGCACTTGTAATCCCAGCTACTCCCAAGGCGGAGGCAGGAGAATTGCTTGAGCCCAGGAGTTTTAAGGTTGTAGTGCGCTAGACGGTGCCTGTGAATAGCCACTGCACTCTAGTCTGGGGAACATATGAGATCCCCCCAAATCTCAAAAAAAAAAAAAAAAATTCCCAATAAACTATGTGCCCATT + KK+KKKIKKKKKKKKKKKKKKKKKKKKKKKKIKKDKKKKKJKKKKKKKKJKKJKKKKKKGKKKKKKKKKKHKKKKKKKKKKJKKKKKKKDKKK=KKIKKKKKKKKKKKKKKKKK2KKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKK.KKKKKKKKHKIKKKKKKKKKK%KKKKKKKKJKKKKKKKKKKKKKEKKKKKKK+K/KKKKKKKKK/KKKKKK/KKKKKKK+KKKKKKK8KKKKKIKKKK?KKKKKKKKKKKKKKKKKKKKDKKKKKKKJKKKKKKKKKKKKKKKKHKKK,KKKKKKKKKKKKKKKKKKKKHKKKKKK:KKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKFKKKKKKHKKKKKKKKKKKKJKKKKEKKKKKKKJKKKKK0KKKKKKKKKJKKKKKKKKKKKKKK,KKKKKKKKKKKKKKKKKKKKKKKKKKKK=KKKDKKIKKKKKKKKK@KKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK-KKKKKKKKKKKKDKK4K7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJK(KKKKKKK7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKDKKKKKKKKKKKKKKKKJKKKKKKK8KKKKKKKKK @rCer/668/25_1883_CCS ATGGGGCAGAAAGCGCAGGCGCAGCGGGTTGGGTGGCAGCAGCATCGAGTAGCGGCCGGTTTGGCAGCAACATCCGCAACAGGTGTAGACAAGATCCCGCCTGACTCCGCCCTGGAAAGTCCTTTTGAAGAAATGGCCCTGGTGAGGGGCGGCTGGCTGTGGAGACAGAGCTCCATCCTCCGCCGCTGGAAGCGGAACTGGTTTGCCTGTGGCTGGACGGACCCTGGGATACTACCACGATGAGACAGCTCAGGACGAGGAGGACCGTGTGCTCATCCACTTCAATGTCCGTGACATAAAGATCGGCCAAGAGTGCCATGATGTGCAGCCCCAGAGGGCCGGAGCCGAGATGGCTGCTAACTGTGAACCTACGGGAAGGCGGCCGCCTGCACCTCTGTGCGGAGACCAGGGATGATGCCCTAGCATGGAAGACAGCGCTGCTGGAGGCGAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCCTCTGGCCATGGGCATGCTTGCGGGAGCCGCCACTGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCCTGCTGGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTTCTTCCTCCTGGACCCCGCTCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTCCCCCACTCCTACCTCACTCCCACATGGGAAGAAGCTGTCATCCCAGGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCCAGACACCCCAAATCTGTTATAGGCATTTATGGATATATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGGCTTCGAGTTCCGTAGACACGACATGAATCGGGCTCTCTGCTCTCTCGTCAGGGAGCTCGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGCAGAGAGCAAGGCAGGTAGGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGGAATTAAATGGGAGTTCATCTGGCCTGGGGTGGAGGCCAGGATCAGACCATGGTGGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGGAGATGTGAACGTTCCCTGGAGGGAAGTTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATATGTCCATACCCAAAACACCCCTGCCCACAACCAGCTTCCTGGCTGGTACCATGATAATAATTGAGCTGAACCTTGGGCCCTCGTTGGGAACAGGTGAGTTCTATTTGAGACTTCTAGCCCAGGAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCCTTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACTTTACACCAGCCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCCTTTGGTCCCTTCCAGTCTCTTCCCCTTTCTATCCCAATCACCAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCCTGTAAATGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTTGGCTT + KK5KKKKKKCKKKKKKKIKKKKKKKKKKFK7KKKKKKKKKKKKKKKKKKJKKKCK=KGKHKKIKKKKKJKKKKKKKKKKKKFKKKKKKKKFKKKJ3KKKJKKKKKKGKK:KKH;KKK:KKKKKJKKJKKKKKGKKKK?KK'KKKKKKKK5KKKKKKKKKKKKKKKKKKKKKKKKKKKGKJK=KKK0KJ0KKKDKKKKKKKKKKKKKK/KKKKKCKKKKKKKKKKKKKK9KK4KCK%KKKKHKKKKKKKKKKKKIKKKKKKKKJIKKJKKKKKKKJKBKK+KKKKKKKKKKK?K1KKKFKKDKJIKKKKKKJKKKKKJKKKK3KKKKDKKBJKIKKKHKKKKKKKKIKKKKKKJFCKKKDKKKKKKKKKKKIKJKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKGKKKKBK@KKFKK?KKKKIJKKKKKKKKJKKKKKKGKKKKKJK8KKKKKKKKKKKKKKKKKKKJKCKKJEKK=KKKJKKKK4KKKKKKKKKKKDKAKKKJKKJ3IHKKKKKKKKKKKFKKKKIKKKKKKKKKKKKJKKKKKKGKKKKJKK@KKKKKKEKJKIKKK>KKKKK-KKKKKKKHKKK)K=KK/KKKKGKKGKKKKJKKKKKKKEKKKKKKIKKBKJKKKKKKKIKKKKKG9K9KK=KKKKJKK9KKKKIKKKKKKKKKIK)KKKIKKAKKEKKEKKKKKKKKKKKKKKKKKKKKKKJKKKCKKKKKKKKKKKKKKIKKKKKKKKKGKKKKDKK@KK#KKHKKKKKKKKHCK$KKK>KKKIKK9KKKKKKI8KAKKJKKKKKKKKKKJKK?KKKKGKKKKKKKJKKKKKKKKCKKKDKKKKKKKKKKKKKJKKK.KKKKKKKKKKKKIKKKKKJKKKKKKKKKKKKEKKKKKKKFKKKKKKJK @rCer/669/2781_52_CCS ATGGGGGCAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGTGAGCAGCACTACGGCCTCCTCTCCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCCGCCTGCTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAAATAAAAGGCATCAAGCAGGTGTACATGTCCCTGCCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTGCGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGGAATTTCGATGGCTCTAGTACTTTTACAGTCTGAAGGTTCCAACAGTGACATGTATCTCGTGCCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCGAAACAAGCTGGTGTTGTGTGAAGTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATAATGGACATGGTGAAGCAAACCAGCACCCCTGGTTTGGCATGGAGCAGGAAGTATACCCTCATGGGACAGATGGGCACCCTTTGGTTGGCCTTCCAACGGCTTCCCGGGGCCCCAGGGTCCATATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTACCGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCCCAGTGGAATTTCAAATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGTGGCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCCAACCTTTGATCCTAAACCCATTCCTGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGGCACCAGTACCACATCCGCGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGCCTAACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGTGTAGCCAATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGACCGTCGCCCCTCTGCCAACTGTGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTTCTCATGAAAACCGGCGATGAGCCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCTGTCAAGCCCTCCTAGTTCTTCATCCCACTGCAACTCTTACCCCTCTCCCAGTTGTCCCAATTGTAACTCAAAGGGTGGAATATAAGGTCATTTTTCTCATCCTTGTGCCCAGTTAATCTTGCTTTCTTTGTGTGGCTGGATAGAGATGGGTCAAGTTATAATTTCTTCACACCTACCCTCCTTTTTTTCCCTATCACTGAAGCTTTTTAGTGCATTAGTGGGAAGAGGGTGGGGAAACATAACCACTGCTTCCATTAATGGGGTGCACCTGTCCAATAGGCATAGCTATCCGGACAGAACAACGTTTGCAGGAGGGGGACTTTTCTTCGAGGTAGCTGAAAGGGGAGACCTGACTTCCTCTGGTTAGGGTTAGGACTTGCCTTGTGGTGGAAACTTTTCTTAAGAAGTTATAACCAACTTTTCTATTAAAAGTGGGAATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTTGGTCTCTTGCTTGTGGGACTAGCCTGCTTGGGATAAATGCCCTGCTCTGAACACGAAGCTCAGCATAAACTGATGGATATCCCTACCTTGAAGAAGAAAAGGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGATTTTTATATTTAATGTAAAGACAAAAATTATATGTATGGTTTTGTGGATTATGTGTGTTTTGCTAAAGGAAAAAACCATCCAGGTCACGGGGCACCAGATTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGAGTGAGGGAGGTGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATGACCACTTCTGGGTTTCTGCCCTGCCCACCCTCTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTAGCAGTCACTTGATCTCTGTGGCTTTGGTTTAAAAGACAGACACTTGTCCCACTGGGTTTAGAGATAAGAGTTGGCTGGTCAACTTGAGCATGTTACTGACAGAGGGGTATTGGGGTTATTTTCTGGTAGGAACAGCATGTCACTAAAGCAGGCCTTTTGATATTAAATTTTTTAAAAAGCAAAATTATAGAAGTTTAGATTTTAATCAAATTTATGGGTTTCTAGTAATTTTACGAATTGCTTGTTTGCTCAGCTGTCCCTACCTCTGCTCTTGGAGGAGATGGGGGACAGGGCTGGAGTCAAACACTTGTATTTGTATCCTGATGTCTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTATAATAAGAAATAAACCCACCTTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAAGTCAAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCAAAGGAGCACTTATAATCACC + 0,*)'&$&,0*,%(&,*.,,1.*-02-1001/.+,-+%*,**$,,**,/*0/1+,'&*)++-''(**'+',(/,111,0.1/2120--+%/0(054+-,,%(''+,,,./**(-.)323+012*,,/)..-1/,/.--,,33/0/62450.3'3152/-).+10%1%54.10)+5430/4/,2-/1/55+00-21/563.,15411)13224/*430.//213.0.2+405.,-3-,./(-'.0/.2-.2*20*0--23)0)02)/(*-0-.*.,/'10+2)02./(..0.545/4.13.2&,+(.05255//(31,4/54623-3.*,540/,/%1464-/2-1)--.-4/2./312222/4122,440/%264-.5222/126660133&1,)1$3-6230/-0..-*-143&01))144+(*2%0*.346/.233*1.'01-6653002.605-5052/)0+*)31.*(//2./'..0.(,..4-41-34-114*-/-')(%($$).,,&4/310((00%25+/.'20,),2/))$'0)30'334351,(+*-4-(321.'465,.'04$-21621-1,.&+'3*435.*'+(*1*1.1.-*'&*.4,'--2.-3+03,/*/+,+(46121555251.003/2455.&%$,%)/-1)1*-'&0,.,)).-..$',&+)),&1/-0--,&/0--,)11../0)0-)',%0+)-+111+,()%0,/0+),/02/+**--%0.-++)01,1-21/00+(,/10-)%2/./-*,*0/)'**.*&*-+1,*+&-0'++'-.0./1.0+&.1/1.,-,,-'))((%,../-'.-.11-/.*.'#-(1010+00,2/*.0(00+-2*.)('$/&(*-'/,+,)+('$+*111,+1++)()$&--1/-,+-+0(/*+#''+-*+%+/*-00100+,00,.)/+*0--1.(,('1+1-0/'//*1/')*,+)+.&&*.(+((',0-*-'-***,-*&)*&''$,*(,-)0--+*)*%&**)%-(.*1..$$$#&))(-/(*$1',2.0-.+00+,-*+1*1-0////*/0),)+,'0,/+,)&(,)).,,'-'))+0/,+'+/1-0&0*(&--.//&.,',+&-+1-/)0$'++.&+&(,/%1,.*0-%(+)..211/0**-*$,--*+'(#('.*,+(%&&$$&%),(%$*)1121-..+'.-,1//+,,+'+(&,(*+-'+&+).&.+.'+,,/+&'+-$,.+(*,)%("%(&&++*+)+1(+*())'**.0,1...1-02-+-+$.2/')'1++1+00,,-$&.(%-.*(+',''+(*$$'''*(+'')*+'+&*#*(**1/%&**.%)+$$-*,)*)'.0//*#")/00'*+&)&0''&'($-+,0-*$*&&/201/01-0*'#)&"#&)(#,%),&$++,/(+&$))'&+('$++)$$,-)*&-')$&'***+-*,/%,+/(*1,-+..0/.11)--(/1/(,/0.,12/*)*00$0.,+(%++,-.)'-(-,(10/'//1..-)0.*.'***,/+&*.,,/-/*(,,0+/1/-,.0./(,11/,%'0.0/.')%#+,/0**1.*,,.0/0,-.//0&+.+0001(*)'+/,-0&-..(($,0/1-0-,,1.1-+0,-,.'&$-(.211-2(%-#+,//.-,/.1/*+/11+/0-2.*2.12/1*20%$-),.25%0135-254-./4/*1(2&/+(00034+400+03+%-&5514).1)101123/(5-.44+2./,1/034.-)..35)/22340&**,2+44,#-..%0441(421,+)1044+553)+(32,10-*43*131/,643/1/.513-5/5.+0$*1,-+-+'5-3(../22)-,2151(2-61))26.000*03-13)).532*)&(%+13+%'*'*)#,&10334,0--66/.',-''(&.,),1,).+$*20,*0+22+-)/.502*/0432&1-/0032$255.41141.3,00..'*(0)041,&214255604)5.1)50)5,1/55*0+4(.5553162555,000/-431552211.(*0)&%-(10+-31612416/-02222/21%6315+**'1/+/1.-+./635025.66+51053(4633/.66-/%022/-6/20.36/+/056115.424*+(,)0*5(./0266665411416255040020,/+0$4140)015(0.0-2./0/5/5'1/%.$*)*#-/$+.100*,),(,0'.+0)+(012/-.1/*+00,01*.'/1--*/+---#)(-&/11(1,'1.1'&/2---.'-,0010+10*01.-./'00*,-2/002-1-10/'1-(-.-(.$+0//%-+*))#+*+'*+)',,,)-/--**))((&*+(,,'+#+,&-1)0-.',(($))$,*01-210/+%,,0(**%),,(*,&#&$$)/)*,(/+++2.-&.-)*,,0*(,-$.+(+(#%%*,&'(&%)%$)),'*)&*,'%,*')&+,,'%+)*$&)&)'(%-*-/0+/+&0*0--.1000.*''((,$,-0*-+%--+%,(*%/.$,,&*+().(.*.,*&+)()*)-/+210/11,($.+,,-,(/,1.-0-.010210'+)-+*101.12111-,-*-1+++*+10).1-**/))+('%2-+,'-1--&0*,,..010)'-,&-0$0201-.+/0,*&&('&(,.1'&..'0-2/0-/0&%-&+)-+,/&0,%,1(*)%-* @rCer/671/25_1642_CCS ATGGGGTCATTTACCAGAGGGCGCCAGGGCTGCAGTTGCATTTGTTTGCCGATCAGAACCCGAGGTGTGCTTGTGGCTACGGCTGCTAACTGGCTGCGCACAGGGAGCTGTCACCATGCCTCACTTGTACCCAGCCCTTTCTGCTGAGCAGAAGAAGGAATTGTCTGACATTGCCCTCCGGATTGTAGCCCCGGGCAAAGGCATTCTGGCTGCGGATGAGTCTGTAGGCAGCATGGCCAAGCGGCTGAGCCAAATTGGGGTGGAGAACACAGAGGAGAACCGCCGGCTGTACCGCCAGGTCCTGTTCAGTGCTGATGATCGTGTGAAAAAGTGCATTGGAGGTGTTATTTTCTTTCATGAGACCCTCTACCAGAAAGATGATAATGGTGTTTCCCTTCGTCCGAACCATCCAGGATAAGGGCATCGTCGTGGGCATCAAGGTTGACAAGGGTGTGGTGCCTCTAGCTGGGACTGATGGAGAAACCACCACTCAAGGACTGGATGGGCTTCTCAGAACGCTGTGCCCAGTATAAGAAGGATGGTGCTGACTTTGCCAAGTGGCGCTGTGTGCTGAAAATCAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAATGCCAACGTGCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAAACGTTGTCAGTATGTTACAGAGAAGGTCTTGGCTGCTGTGTACAAGGCCCTGAGTGACCATCATGTATACCTGGAGGGGACCCTGCTCAAGCCCAACATGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCAGAGGAGATTGCCATGGCAACTGTCACTGCCTGCGTCGCACTGTGCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCGAAGAGGAGGCATCACTCAACCTCAATGCCATCAACCGCTGCCCCCTTCCCCGGCCCTGGGCGCTTACCTTCTCCTATGGCGTGCCCTGCAAGCCTCTGCACTCAATGCCTGGCGAGGGCAACGGGACAATGCTGCGGCTGCCACTGAGGAGTTCATCAAGCAGGCTGAGGTAAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAAGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGGTAGCTTCTCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGTAGCAAAACATGC + 56(36./73,552/0678,9763334*0981545926917.242+898.6/5:868,67968604-6319)3332441736;453-18;19697.17:671,(39175389/636459'5656848698(1.99-0/433829.79:3:74195:77;5:*7.037:9852:5/73.1628959-237(855(44428639:6.9076785:536.5454157:84275434.6./3/5839259:83316659295817::776.95398:8577808039867622:85-40-794;3366:89784669464427636051626:7:8:98:795324;596;:-79838798,:781.+132573.1066;98874/0&257976&45699,984.1614:3:264897638/9189254728.1229:68.5.9)5,7477797767/647399;7::97:94:688:9956;772:77;9272875250547::;499;95%1436:90917'75655;47618548839:;:2/+424265629:2--004+4725468:985813*83476575333::940169:54485976;93:1462562754;726:6;:803858979;66;468387:541449:456467188798823:96/54/59597;0:366-.715,244.348097469:9;120-%344$50-1441279:85897'543-56563/76:6949616224455498;26/566734694446758:80/371944:52::82679976736:33654387359:88-3586,84;585.5796/3:/3-3786851$766:725.4419:7;86892-63651,315/)0-002304315213)&/03.24663-1/.0/13530466526646252666566455+3)+454361(442314665*4.5.4563326561+5/122/0(5333*2%122460663064654)3-/0/63.163/-#64003066445050451565.266/1565.641641211655660224514414./64600-36.3.34+-23*406212410-/12144564*243115.%002.446550241*543-1/%1-0+1,,(0/55442011*260421036415446245103.2%,/25.0.432112.4100/666463346542/231-146034/00412.34//),302'01024533/54203564345/01424565&41-3.454--010-0356346644441/(/1635*3300.100%1165161565326555104503465+.4/3,3554256241/+1(/,162246.452425)42,*51+/)32240566144505435-246651456/44%/.245+5-/+3610350/4)/1665063034'1/1334466440,4364316624.30066+4112641'0/1013)35465644.360244),/10-264-45(3211341462043''33**461./4125.2*231564030664615605536621414*2004266215653061,3.343*421456/. @rCer/672/25_1909_CCS ATGGGGTCCCCGGCAAGCGCAGGTCCAGGCGGTGCAGCTTGGGCGGCCCAGCGGATCGTGCCGCTGCAGCCGAGCGCAGCCACAGGAGGGTATCCAGAAGCCACTAGCCATGGCTGTGGGGAACATCAACGAGCTGCCCGAGAACATCCTGCTGGAGCTGTTCACGCATGTGCCCGCCCGCCAGCTGCTGCTGAACTGCCGCCTGGTCTGCAGCCTCTGGCGGGACCTCATCGACCTGGTGACCCTCTGGAAGCGCAAGTGCCTGCGAGAGGGCTTCATCACCGAGGACTGGGACCAGCCCGTGGCCGACTGGAAGATCTTCTACTTCCTACGGAGCCTGCACAGGAACCTCCTGCACAACCCATGCGCTGAAGAGGGGTTCGAGTTCTGGAGCCTGGATGTGAATGGAGGCGATGAGTGGAAGGTGGAGGATCTCTCTCGAGACCAGAGGAAGGAATTCCCCAATGACCAGGTCAAGAAATACTTCGTGACTTCATATTACACCTGCCTCAAGTCCCAGGTGGTGGACCTCAAGGCCGAAGGGTATTGGGAGGAGCTGATGGATACCACACGGCCGGACATCGAGGTCAAGGACTGGTTCGCAGCCAGGCCAGATTGCGGGTCCAAGTACCAGCTGTGCGTTCAGCTCCTGTCGTCCGCGCACGCGCCTCTGGGGACCTTCCAGCCAGACCCGGCAACCATCCAGCAGAAGAGCGATGCCAAGTGGAGGAGGTCTCCCACACATTCTCCAACTATCCGCCCGGCGTCCGCTACATCTGGTTTCAGCACGGCGGCGTGGACACTCATTACTGGGCCGGCTGGTACGGCCCGAGGGTCACCAACAGCAGCATCACCATCGGGCCCCCGCTGCCCTGACGCCCCCTGAGCCCCCATCTGCTGAACCCTGACTGGTAAACAACTGCTGTCAGAAAACGGCTGGGCTTGGGAAGGGGAGGTGGAGGCCAGGCGTCCCCACACCTCTGACCCTTGCCCCCAGCTGCCTCTTCTTTGTGGAGCCTCTCCGCGTGGGCAGCCCTCACATGCTGGGGTGGGGGCCAGCTCTCCCCAAAAGGTCTTGACCTGAATGATGGGTGAGGAAGCCTGCATGGGCCCCTTTCGGAGATGGAGCACCTGAGATGTGAGAGGTGCGGCGTGTTCCCCTGGGCCCCTCAGAAAGTCGAGCTTGGAGGCCAGCCTGGATCTGTCTCTCCCTTCCCCGCCTGGGACCATTCTACCTGTGTTCTTGGACCCTCAGAGCAGGGACAGGCAAGACATCTGGCAAGCCTGCAGCTGCCCTGATGGTGCAGGGAGGTGACCATGTAACTCAGACCAGTCTGGAAAGCGGAGGGTGGGCTCGTGGGCCATGCTCTGCCCCTGTCTGCTGCTCCCAGTCTCTTACTCTGCCTGCCTGCTCAGAAGAGGTGGCTTTAGCCCAGAGGCTCAGGCCCGGTCTGAGATGGGCAGACCCAGGGTGGAGTGGGGTCCAGGTCAGGTGTGGACTTTCCTCACTATCAATAGAGCCTAGAAGCTAGATGGGTGCCAGGTGGGGGTCAGGTTCCCAGAGGACTGAGGGAATCCTGCACAGGATGTCCCAGGGTAGGTGGGGAGCAGGGTTGGGACCCGCTCTGACAGCTGGACACGTGAGCCCTGGATGAGTATGGTAGGGTGTTTGAAGGATCCCCTGCCCACCTCCCAAATCCAGGCCAGACCCCCTGTGGCTTGGAGAGCATTCCAAGCCCCCACCCCACCCCTAGAACTGGCATTCCCAAGACCTCTGTCTCCCACCCAGCCACCCTTGGAACGTGCCTCTTGTCCTGCTGGAAGGACAGCAGTGTTCTCCTGACCTCGCCCTACTGCATGCAGTCAAATAAAAGGTGTGCCCAG + JF;KKIE0KJJ9JJ9KKK<=;=DCHIHEIJ=IGKKB@EFJI>:CA9FJAGFIKIK7JGHKD=IJJE?BDJAHGHK@KIAHBJI>E:BDA;4BAECGIGCJGIFFJJ=KDHIIHFI;=3HDHCD<>=:CCFCDHE>HB5HCIGEIJJ>G4H>AJI:IIIJG:@DICDHEHHG.@AJIDJHDKIJHJFFF>FJDAHKAKKE@BCHJCIIFJ:=KKK;FJK@BAHJDKJKJHIKBJC?FIHDHBEC;9FAE+;JEKAKGJIIFI@JFJGK8=DAEKE@KFCBKGK/FCGJBKG>?6@*KGIGIFHH=KEHIKJKJGKJKIHCHDIDEEJHIHHI6;JKDKHKJJGEKF=IAFHJKFKJ.EI37AJJGJIGJAHJ?DDAEJFIIJFJGF7?GEBEBGGBGIFBF>EI@J3CFG<:H9EAHFJHHFH1>ECDIHCIJKH8>HCJDC?.@HGJKKIKG=H>KKI;HC)KIFKIJJ-EJFJJJJGIKKKKHKJKIJIKK/HHCHDKHDKGEICIJHJE3JKJBK?CAJKKID4FF=@FIICJIKBKIHE<=IIKEHJHIKCHFJIK8KHEAGIIDKFEJKJJFKFCKDIKKKGKKK>KEHKJHKJJCKK;KFI=KKJKKHJA@EKJIKHJIIKJJKGCKJJIJBKJKJJKJKJJ6JDKKHK8HK>KJKKKAK8KJIIJIJK=DKGKIBKIKDIKKKEKFJHJKIFIGG;GKBIAKKKJ>GB.KKEFJC>FCCF>KKJJKJKJFKFJKIKKKJKFKJCCIKKJIDIIJ@IFCIJAJJEKJ5HHG3HHJIAAGDJKIKJAH>CBC@AEFGJD=GJIF=AII)G5DEBEC>ECFBGHKFBFGGCFFCIK9AHH@JJEE:KKGHH1GF;IG@I;KKDICKGGHJGJCKKCHHHAJHH@EJB1KKEA6H@AF=KDHI8<=D4=8@JEA?HBCID9IFIIHG:F;@FAG=HKFJFC7KHJBGJHD@BI;IGIKJI8HKE'FFGIKIEGKIEJJKFHG3HIJHHKGHK3JJHD<.BED>:GIKJHEEF?F;KKB8D6JICIIADJGHGFDCI8HE9=ECEIGKDAJHFJGKC=GKGKGJDHDG?DA>BEJC>AAIHKJG?GJCJDJGFB5AD=JKGKIHK/;2;?8:=,<4<:89->:2;<97<;4:6265.1,+774.7-35<;;3=<=1=41868-:8:6<1:1;;97><*90?==8=;5<>2;<;=>::<:787=997979=248,769=<<87:0/><>10=9373>=<>565499>83<73<:3:4>77786=9794:?<6<7>=5>>2>;4;:>483$345997%8685:%35133749>90<3:9;<3184-848868;75>92;9>>=6=:>68;;?;;3>=7:6???;8*5;<9:9=:8?8=4;:3:>3?>955.>=95452;2?9::;82==12.39;7()2368:74=8=><68+,628?=??8>:;<>-771?=(87586/8?<<<74-:556;7=+.41=<;>:=1;=?<;76;8>*<969<:;><>93393>>7<74;=>?5:?;>;:>=?;+:7<>:<868><;4?7>>:41=)77839;:?>??>=66889=7??>7;?>;87>8=;;<3;:>2==<9.455;5977?:=<69:<7<=87<77;><:4<=09?5<=?>8>>6;>@?B4A>?7A=72<;8?-9:A9?2B??>;=<4;=B?@B8:88?6AA<@/<;;?;A;@&=>8:=A?B,)8@?5C>;(9<@95:569>=9<;><389><:2<;::64:73;777(/3;2>:>A@AB5/==79A.<=;36+=':<>B>=CB?>8:6@@=6/6,9.@6:A4=58@?B7=6?;?AAA2?3;:4:>@C?A<0:58?>72@:=?=@=>@?/;=:18=<=><8B3?CA@:A::8;<=;5?A<4=;,@5;?:AB>CB5:%::64@:>>>-<==?<8?;5>@67A==B@<(<=@C;A@A+<;>8>;49=:>>A>@CC@7@=5>?=A;9ACBBC@CA=>B<<9;)/>:;@4=924A?@?B??BC5A8?(???@A==27@BA<@AA?CC@%=?>89;<;>=<=<::0=1?7>;;;<>@6=B5'@A?:=>A;/>;;7:@@@?AA:A653491B=A3AA>A?8A8B9<8@@6B:9@@1<9<5@>;A<<;;CC;9=?@A<>-::17=5=:??@B3B=@B>CB8=8<7:8<@-C48><=>@?5<6&97;==?CB??>A7=5?=7:>;>?6==A?70AC>5EBEF:<@:B3DBC=AGEDFBAGFEEEEE>E8D><5@F>6BDDBC<@7<>?B?>CFF6DA;E(C@BA;>:=9EFCCCE3@.>=E4EBF==@CA9F9A@7BCFCCF5A>77?C;@;?5?C;6B7E;F4A?:C??5=BB@E@E<@:;DA@FGBFC@D6?F@F@B@?BBF:AFD@:-AE?@CEBE>EEBD?=;@5DEE*CA?C;E@E?>BBF5B&CCA??1CB;A=>EE9?E@<9G<=DDC>;?CABB>FA?DAA")?CBCE@?:;;:>8?B@.DE@ABGA#)D3EDCB:4A@AF1B5=6?=B@DD@EE;8A%C4&@@?F8C;@E;@D=B@FGFGCCF=@A1B>DBG:E@CEF:AGGDFEB?=EDA@<7>BEB*AACB@CAAB==BFB96@>DB9?C?C==<:;A?7:E9B/@@>3<18@@2?=7:9@:7>AD;>DB>G?B;??7AFEE?CAAEB?GEG8B=9@CD:>@6::E@4;:39;2>@9B?E3E=@3@;7:ADD@=BBF>=2A(CEEBADE?A==<:868;@==:35:98>><=@??8<:<88;;:1;=>89>;@<:=7?>A@6?;&:BDFDBDFFEDA:@BF?FF>DBC:>EE=>CF.DBA1=ACEBABE2B8C?CBEGDGFE% @rCer/675/2333_60_CCS AGCAACTGCGTCCAACGATCACTCACTTGCTGTAACAGAATGATTATTCCTCACGGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGTCACTGGGGTGCCTGGATGCCCTCGTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATCCCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCCGTGGTGCATGGCGTCTGGTACTTCAATAGCCCCTACCCCAAGAACTACCCTCCGGTGGTCTTCAAGTCGCGCACCCAAGTCGTACACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGCAACTGCACCCTCCTGCTCAGCAACGTCAGCCCCGAGCTGGGCGGGAAGTACTATTTCCGTGGGGACCTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGCGTCCTGGACATCATCAACACCCCCAACATCGTAGTGCCCCCAGAGGTGGTGGCAGGCACGGAAGTGGAGGTCAGCTGCATGGTGCCAGACAACTGCCCAGAGCTGCGTCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTGGGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCGCTGCTGCAACTTCGTGCCCACGAGGGAGGCCAACGGCCACCGGCTGGGCTGCCAGGCCTCCTTCCCCAACACCACCCTGCAGTTCGAAGGCTACGCCAGCCTGGACGTCAAGTACCCCCCGGTGATTGTGGAGATGAACTCCTCGGTGGAAGCCATCGAGGGCTCCCACGTGAGCCTGCTCTGTGGGGCTGACAGCAACCCGCCGCCGCTGCTGACCTGGATGCGGGACGGGACGGTGCTCCGGGAGGCCGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAGGACGGCGTCTACGCCTGCCTGGCCGAGAATGCCTACGGCCAGGACAACCGCACCGTGGGGCTCAGTGTCATGTATGCACCCTGGAAGCCGACGGTGAACGGGACCATGGTGGCCGTAGAGGGGGAGACGGTCTCTATCTTGTGCTCTACGCAGAGCAACCCGGACCCTATTCTCACCATCTTCAAGGAGAAGCAGATCCTGGCTACAGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCGGCCGTGTCGCCCGAGGATGATGGAGAGTACTGGTGCGTGGCTGAGAACCAGTATGGCCAGAGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCTCCTGTGCTCCTCCTGGAGTCCCACTGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCATCCGTGGCCTTTGAGCTGCCGTCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTCGTGTACTCCGAGCGCAGCGGCCTGGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCCCAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAGCTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCTGTGGTCGCCTTTGCCATCCTGATTGCCATCGTCTGTTACATTACCCAGACACGCAGGAAAAAGAACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAGCCCTGCCGTCCTGTTCAGCAGCGACTTCCGCATCTCGGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAGAGGAGGCTGCTGGGCCTTCGGGGAGAACCCCCAGAGCTGGACCTGAGCTATTCTCACTCGGACCTGGGGAAACGGCCCACCAAGGACAGCTACACACTGACGGAGGAGCTAGCTGAGTATGCTGAAATCCGGGTCAAGTGAAGGAGCTGGGGGCAGCCCATGTGGCTGACCCCCCTCAGGACCCTCGCTGGCCCCCACTGGCTGCGGGCTCCCTTCCTCCCAAAAGTAGCGGGGGCTGGGGCAGGAGGGGAATGAGGCAGGTGACAGTGAGGTCCTGGGGACCTGACCTTCCCCTCCTTCCCAGCTGCCCCTCCCTGCCAACACCCCCACGCCCTCATTACGGCTCCTCTCCAACCACCTTTACCCTCATCTGTCCGGAGAGGAGCTCTGTCTGTCCGTGTTTATTTATTGCTACTTCCTGCCTGGTCTCCTGCCCCGACACCTGGCCCCAGGGCCTGTACAAAAGGGACATGAAATAAATGCCCCGAAGC + ).,++040.)--2*54+'*/.544656111,-3-%...01,/4-+1/*32+)()'$$%%,+$0*=<95<14<:;;:(;89=??<8=784;>;0<47789'370419=>13977,7,00203#7543::054&7=5>08*6>@6@-2<84:(6/9446;B:4;*'<&2.2429$49<7-+00=15>>49;;:?:)975:7=88527>88+?9EB880@:9;C>8;@-?::6-=->58*9*95EIAD=:DFD=6(0581E@7<;>DA?@=>5G;J@;>:01>5>;+0,;A?:2B?C@C9K9EA34?D97H>III>B?DF6B7?27A@=;4=/D;G:F?B(%9:CEKID:804@>4@=?@B2?CFF;BAFAHIC:;JB=5CA?FB9?:;7/;(4993+:3EBA:AA=4=@HJGD:8F;C:=>F>=C89?D,DBC=DBBHD@7>>8FGEFCA/HCE?4FD7D>JFDCGE4A?>B32681+$0+08B=38.%;5850=8A/.:27=9BBC==E:?>AC9;1*>CIE8>/F@I=CJ=GD90A6@AA:39>:EJ>IEJGGJB?G=DJHIDIJD7>?AE:@87;:E6?89@3=D90ED>969A9BE8FHIGGFBIHDIHC?;AI?A>>=6B:9@9=?34397*===?=;>G?4>9DBDGACF@/B:CEGE7IID?IJIJC8G0JE;EE@A?FDE<4276:A7EA8HEDHHA@AI?C@?5DAA>;E>D4:9B>EC=?C:B?H9B@2A8D&A=25.B.88BBEIHFG9?;ADHBJIKFEBFIK>JKFG<=@G=GCHIE-8?=E;:EC<92BKHFCH3F3EG4EKII@7KJJ?;@DECC:AFJA@E3GKJJBEHGG@CE6EBAGIBFKCDB?DCKII?>2FHFGFICFHI;G=GGGJG@9=?>A=JH@7C@?E@4:79C<3;;A+=AD7CC8<6?4AB?05=>7BEHDBEEA8<98:6E=(E9G>C<>@6FDBD>>D:9DCFB68:=?83??A4C8@1589@C:BCD1;8<8;*=>638889BD9B?3@@E9>;@B9;@=A@?:<<@@7?@=68A=A>5<3723:57:38:=?-@B<@ABD@ADBC<0DG@;A>@<06BABB<@@07??;EB@B;B@CA?<75@.>=.:DEA25;?793?=>7=89E?:@47?G@3BA?<&8FE;9ADEEA==7621=<=:@@:3:AC?@-16<4;;9;5B8?BB8F@@6>ABA4E<587@6@4B>@?;>F?>8<@ADBA6C@3BB<:>D@A?@8;:?9A7=2<@<28<-4?6BAF;CD?@C*5.30?<786?>8.;<9'87D?F=20(:=::.>$?>5>B:;7943.=>:C>;?EB?9;?0BC?D?7D<@9D;CDCA69=@8+357@;;%@;A6BA+?A@?B:8<6>AG@@;<<+:1-8E9E>E?CAA9:=?DCFF<;AAAA=<8)26:23559B;=<648=*994=6/?:9989F8>@>>9::><=B);D7C0$,9+;:56=<:8047ABBAAD9@<=A3<7999&=FC8DD8@?B>=:>@<981:<9?D:9G<=C@5==E:@@BB<@>>EC&7:7>B8:>7:7B?>:9=@@>*>9+=? @rCer/676/2095_52_CCS ATGGGACGGCCAGTTTCCGCAGCTCGCCCTCACTATGGCGTCGCTCACCGTGAAGGCCTACTGCTGGGCAAGGAGGACGCGGCGCGCGAGATCCGCCGCTTCAGCTTCTGCTTCAGCCCCGAGCCGGAGGCGGAAGCCGAGGACGCGGCAGGTCCGGGGCCCTGCGAGCGGCTGCTGAGCGGGTGGCCGCCCTGTTCCCGCGCTGCGGCCCGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGTGATGGCTGCAACGGGCCGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGTCCAGACTACGACTTGTGTAGCGTCTGTGAGGGAAGGGCTTGCACCAGGACACACCAAGCTCGCGTTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGCTGAAACACGGGCACTTCGGGTGGCCAGGATGGGAAATGGGCCCACCAGGAAACTGGAGCCCACGTCCACCTCGTGCAGGGGATGCCCGCCCTGGTCCCACGGTGGAATCAGCTGCTGGTCCATCGGAGGATCCCAGTGTGAATTTCCTGAAGAACGTGGGGGAGAGCGTGGCAGCCGCCCTTAGCCCTCTGGGCATTGAAGTGGATATTGACGTGGAGCACGGCGGGAAAAGAAGCCGCTGACCCTGCCTCTCCAGAGAGTTCCAGCACAGAGAAGAACAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACGCAGTCTGGCAGAGCAGATGAGAAAGATCGCCTTGGAGTCCGAGGGGCGGCCTGAGGAGCAGATGGAGTCTGATAACTGCTCAGGAGGAGACGATGACTGGACCCATTTGTCTTCAAAAGAAGTGGACCCGTCCACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCGCATCTCCCACCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAGATGCTGTCCATGGGCTTCTCTGACGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAATTACGACATCGGGGCGGCTCTGGACACCATCCAGTATTCAAAGCACCCCCGCCATTGTGACCGCTTTTACCCACCTCTTCTGTGTCCCCCTCTTCTGTCTCGTAGCTGTTAAGCTAGTGTAGAATTGCAAGTCTCTGTACGGGCCAGTTTCTCTGCCGCCTTCCAGGATCAGGGGATCAGGGGTTAGGGTGGAAGAAGCCATTAGGGCAGCAAAACAAGTGACATGAGGGAGGGTCCCCGTGTGTGTGATGTCTGAGAAGCAAGACCGGTCTCCTGGGTGCTCTGGTTCCCTGCAGCAGGGCTGGGCCTGCGAGACCTGAGGCTCACCGCAGTGCTCCTGGCCCTCCCTGCAGGGGCCACATTAGCAGCCAGACATAGCTTGCCTAATGGCCTTCCACTTCTCTTTTTAAATGACTCGGAGGTCCCTGACATTTAGTTGATTTTCTGCTAGAGACCTGGTACGCTCTGATTTTAGATAAAGGAAGCCTAGGTGTTGTTGGCGGGTAAGCAGGGGAGGCGGCTGTCTGGCACAGGCAGTGGGGAGGCCGGGGCAGCCAGTGTGGTGGGCTTCCTGCTGGGACTGAGAAGGCTCATGCAGGGCACCCGTAATGTTGGTTTCGCTGAGAGCTGCCTCCTGGTCTCTCCACCACTGTAGTTCTCTCATTGCCAAACCATCAGCTGCTTTAAAATAAGATCTCTTTGTAGCCATCCTGTTACGTTTGTAAACGATCTAATTAAATGGCATCAGCACTTTAACCAAT + 8952%/769>8>784)82835=3:=8;@5:>=)4=785<=1;>3A66>2712>46.<;7:*8;;8>E3>9*=5;2.585088?==G>=7D@6H>DH8I>F6B7D@6E>;G*D@/;9@87C@C?F>@BE)C@8:AHDDAEJ:EH=E@C64&5B.?@6B,DEJ.278#C@$A>D96EEF><=/@6;GEGH<@1,D-=:<@<18DAHAEBBFBG>;@III8A=D;EEA216*GA,E?86=<0AB7GAH+E+@FAB61I?E;?;AFEA;DFIHBAA?//7<8D734?DD@GF)5>7?=@?A$4'@E>>6C17DE/3B0:?)BAD&6F:35/30:=:=DFE,C?>'B@@?92456AFB2>06@;;9>DBHDCAACCC7<@=3=B6/B%=3@;<6<4A*AE1;BD7>=//;?41--3E@@@EF=.<7>9//91+@.004($3>9A=9<>4&?9%9).D*B@G><>:F:=>D:E6C*7DGB9DG0?@7BC1@A>6?<>G>DB=;@@?9=*D?A338/AA,:C@::E99GD4>?F==B1<;7>6B<2??>E<=E+9B@F3BAB27?A68757@@7&B=)?6BCD:A;/8<3:?==)5?778/0A6<23=4=AB8E@3>AC(;C@ED148:3>23.3;-/,+B.?=300F837>9BGD?E@,8EC()7&/<6?%=?;B?%=B>/3<-E55A:.)BF,A11A8224:+22+;6&>9FC:<6@66G;9;3B@@7;9*0<>7@9ABEGE.4BCG:AD/F;08EB*G:?=7(>?CG8A@>2A@3>,**,&?A;-84B?;=9677.:5'67@FA<.D4C187A6EB@%A1=B(@BBA-:@56B>;>GF;94D=?C<@79>;2>AA<<68:8+:AA3DED-?EE.?<8-/7':AD7<>9@A8A1D8<*AD?EE5A?<>DCCG3DG3><8?:??E<8@$@CB(><@2@3A9AAB@9>>B@C3=8@8:CCB2@46DEF/BA::;:4@,@AF2EADD>ECG;0<:599*?6;<>,=B?;C4F>;(AA*B8BAE@>9BAB??2EA<;=>B)98)&:;A-<=8:><;18=B71?@9:1.>B-4B538B38B@59>=EDC;>=82C>@57<=>B4:?1;=(D,<:69,39,)AE'F/@>A+>>98E?A<:CEF>C611><.7:8==B3=;2D=A14E52<1(19A*>B@5BDA%<*7C@1:?7@/>B2?<<<0#'8B.>=8=BB<5AA:5;79431294/$/.9&8=<;63..07/3*6<6:545A95=:6?<0;4;191@<<81>@@886)::2>=A6=4@:@@A<==.27;'6?>=<:9(A=4::;678>=76%965;@989:=-:?+2@-;B>3?443:%/38.0:3$=<,::=>;=>:8=0@?C79@5==B?37+C23;?A=.;<<;8.79>9=;6>4537461-;>;<=;&<=><96$<6@4>B;;;?.2/A3;?4@3>>B2=C9;A<>=?,:?->=8=76@9284%80@@87>B2=4/?8?B0@=):?CB27>A;79@3@6@B2@88/96:-896>:?<+<<<7@:=-56>2=44?5:;,4/.543.>6.4:;$&7;'=@8:=5788AA4630@8.05C4'=C5?@9B<-32??/;>:0<@B5>37;/->1>=6@76;4@B>-@4B;?/8 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CGTCAAAGCTGTACATGGCAAAGATGGGAAAGACTACATTTTTGAGGTCATGGACTGTAGCATGCCACTGATGGGGAACATCAGGTAGAGGACAGGCAACTCATCACCGAACTAGTCATCAGCAAGATGAACCAGCTGCTGTCCAGGACTCCTGCCCTGTCTCCTCAGAGACCCCTAACAACCCAGCAGCCACAGAGTGGAACACTTAAGGATCCGGACTCAAGCAAGACCCCACCTCAGCGGCCACCCCCTCAAGGTTGTTTACAGTATATTCTCGACTGTAATGGCATTGCAGTAGGGCCAAACAAGTCCAAGCTTCTTAAAATGATTGGTAGTTAATTTTTCAAAGCAGAAATTTTAAGCCAAAAACAAAAGAAAGGAAAGCGGGGAGGGAAAACAGACCCTCCCACTGGTGCCGTTGCTGCGTTCTTTCAATGCTGACTGGACTGTGTTTTTCCTATGCAGTGTCAGCTCCTCTGTCTGGTTGTTTACCTGTTCCTGTTTGTGCTTGTAATGCTCACTTATGTTTTCTCTGTGTAACTTGTGATTCCAGGGCTGTTTGTCAACAGTGTACAAAAGAATTGTGCCTCTCCCAAGTCCAGTGTGACTCTATATTCTGGGTGGTTTAATAGTGTTTTTAAAAGTAATATATAATGTGGGGTGAAATGGAGTAGGGGGGTGGACAGGGGAGAAATGGAAACCACAAAAAGAAAACCCAGCTCCTCTCCTTCTCCTCCCTAGCTCAGATTAATCCCCACCCCCAACTTTACCTCCACCAGTGTGCTTGGGATCTCAATGAACTCTGCTTTTCGCTTTCTTTCTGCATGACTATTGTAACTTAGATAGAACATTAAGAGATTTTCAAGATCAAACTGCCATAGCTTCATCCACTGAATTTGAAGGCATCCACCTTTTTCTCTGTTTGCTAAAATTTGGTGCAGTTTGAGTTTATGTGAATAGGCTGGCTGTGCCTGTAGAGCTCTTGTGTTTTTAGTGATGACATGAAATACAAAGAAATTTCCAGGAATGTGTCTGTATTTTACATCCCAGTGTACCCTTCATTTTATTATTAACTAATTAGCTATGAGATTTTTATAAAATGGGGCCGCTGATGTGCAATATCAAAGTGAACCTGTGAGTATTTGTGTGTGTTGATCTCAGTTGTTTCTTCATTGTTGCTGTTTCTGGATCAGCCATGTGTGCGCTTGTGTGGACCTGAGGCTGCTTTGTGTTCCCAAAGCTTGACCTGTGTACAGAGATAACTCCTTGCAATGTTGGACATAGAATGCAGGAGCTACTTAAGGTCTGTCAGGGATTGTCCATTCTGCTCTTGGCCTCTCCTGAGGCATCGTAATGGGAGACCAAATCAAAAATGTCCCATGTTACTTGAGTGGGTACACTGCCTCCAGAACCTGAGGTTGACTCCTGCTTCAGTTCTCAGCTGTTTACCAGAGCCTCCAGAGTTCAGAGATTGAGGAGCTTTCTCTTTCCTGGAGGAACTATCTCAGATTTAGCTTGTGTGTGTTTTGGACAGAGGCTCCATAGTGGTGGCTCTTGAGGAACCCTCACCAGTTTGTTCTCTTCCCTCTGACAAGCAGCACCTGAGCAGATGCTGAGACAGTTCATTAAACCAGGTCTCAGCTTCAGTGCCTCATCTTGCCATCTCCTGGCCAGGCTGGGAACGGGCACCAAGCAGCCGTCTCTAACACCATAGTCCGTGGGAGTTCATGCCAGCAGCTTGCCTTTGAGAAGAAATGCTACTGGCCCTACTTTTACATTCCCTCCCCCTCTATATTGACATGTCACCATTCTGTACTCCCAGATCTGAGAAGGAACTAGTGTTGGTGGTTTGTAACAAGAGTTATATGTCTAGGGGCTTGTGCCTTGGTTTTCCTTTGATTGCTGGTAAATTGAGGCCACAGAGAAATGCATTGAGTGTGAATGTTGTCATCTGTAATCCCTCCCTCAGCTGATGATGGTAGTTGATCTGTTGTAAATATACACATATATGCATATTTGCACTTCCAGATGGGTTGCATAAGAATCAAGTCCTTAAATACCTCCCAATCTGATGAAATGATAGAAAAGAATAAAGTAACATTTCCCAGAATGGAGGAATACATTATTTTATTTTATCTTATATTTTTGTCCAAGTGATGAGCTGATGTGGTATTGCTTCTCTGCATGTTATCAGTGTGTACATCCGGTGCTTTTCATGTGTCATTTGTGAGCCACAAATGCAAAGTTGCCATATGAATTCAGTCAGGCTACAGGGTGGTGTCAGCCAAGGTCTTTCAGGTAGGGGAGAAATTGGTTAGGGCTCCCACTGCCAAATGCAAGCAGATAGCATAACCTGACTGTTATGTGCCTCAGGCAGCATGCTTAGGGACAACTCTGTGGCCTGGGGGACATCTGTGTCACAGTATAGATTGCCGTTCAGGTGTTTTGTACCTGTTTCTTTCCTGACGTCCCCTTTTTTTGTACTGATCCAACTGGGAGAACCTCAGCCAATGCTGGAAGTGTGATTGAAGTACCTCTCTTTTGTGACTCTTGTACAGCTTAATGTGCAATAAAGGAAAAGTTATATC 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S((&#%%'+%.$,),((1116604/.5504610-*40201.883,/5,278:934263067968,76442/%).34066/226/69:8:03&1989.%14:884796;:3140/3/5677/-5-361+318-782278456)5985:3265666/18*447/033444040#36566770305623.22&.01,23.4/5-512206)-(./)&.458784053>57382=?<8).*3178*514+%+0)*24*5+5,4/(7635894430+9773659=46,+8&263.1681,1/+1578#56,/44:%1(868/7604)232)-2','.*5=-689/4:775-7:;6437:=.<9528:7:%81254(264/(851:*9799+=<5%&96&25607306;>9.:==;<>?3=6;:+:8>=:8<*7729>97947<49:9;799903:3*:9<=9=:762718<=4<<=47::>>677,26=26(-6751413-31-52*4025:5:::61:42859/84::67-7<:47469075+7739<'2103*4609<<96-:9837/<739,62:>7;8::+66:4812:627%05,21:4:42**3775656:602734,,)8.3++.-3/0843669;9+58453576.+*+-6)--'10,1+1562$4*.85$3/,/33(671.-4047+2074570452745*2557-'012/5304/4-00.1'3/+00&*1&+2..10--10/(7&)/+2.1.#+)35301/-29364262/961271.,(0'-3651#5:;6587-,506:(6/32/1(45%,,22,.2)24667629305;/23674.1608.5+7752*03-7789/:934:34658+.685/380872-394/6309/29.879:455058735789759:68&456::.4+6*50*+&//05(7663.3999-5/34936.6633:84474,60752086155/8846*68875667::,,86779/;43334985/;2:587410(4499.&45349&7455;:81:=:9*:95%669?89'63..196099>;>;:,-1::;>=>>;8,>>=5*+*3<5-)89:6>288=;><>647;>989&579>::;+425&43520)<52778689+/61-55)4,*41*67+)1-14535;7/-1/==<9-858:54-316:;:,9<889:::436=9.>319)938=7089725'56:>0<:872::9:;==;7008>49<86.84.)/0-$38?*7143476<6870;5/34$8.21=>8(9::5?9;=>>8<17887>34*;:69=7:>38<:):8>865(74:=,397=882*<8*<7:/36=>??>8&835533/1385.38:;;>9:82788;==89;8.*)<69);832408=18:'<71=629737<729>>3:9966-:83.--5*&6:97:;9;:;4;766250/0+16./21<;,=856807-3/.4231+5.+.1-2,//(-,29039939==398:50696;49/;<6-;94938:64285::1<7;:7<;00;;;:=.?=37)119;>==996465513<:=<;6:3677989098379:;69>3==;<9>=8<8<<3>94886<535;77828374:39>;8359=>:076<0/.&,-698<:8;:9/=95;:<84789:96:75=6:79*<=:8:<997<;/>290=768=78-5+3/55$3:4<999/<-')/;=8;7.75342:>;;89869;6=95(*+999+/*70648:65,977504>95;;:06678'62+.20:14?98:8?:7,6898873/1+<76<3>3<<<:72792+69/171147.623<7,.8:59??;:8:7<+<913=':86:;9954>7+=74-23:7<*1.8928495+31.317+63:3+778;<;2=2??;747;9=3:>7<6=7;91:<;:=?2%77')1=2;7<-//+2377+2,,:-94588<,27787=8<3826279.4-,1340&11.0)(3+359;::1&126;.6526.5:4<>1:9>938&109;(<;66548>8739.869<81;3<573;:=>=2<>6/5255<72;8082:/8=;236;<;891066*(698966<:=><;//8:64:>?/:9;8;=+4::>9;?<99145-:2;74%25=9<>>;6=877;5;>=104-577:716$65626954.50'18//**/288:7:5:27309563-8996267156157455664*4**&4294(76/619180.+221338-3/:3657+54.83:99+6(440&56660+50+26:::69.867.8224,6.07//53:)99593)417427099052.0643+60/5-*65(.-2144027:222-'(,0.++)-.'(4'..4,7.6440-,5/0.2 @rCer/679/25_2314_CCS ATGGGGGCACAGCAGCTGCACGTCCTGGGATCCACATCTCTTCCAATTTGCAGCGTAGCCCGAGTCGGTCAGCGCCAGAGGACCTCAGCAGCCATGTCGAAGCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCATGCAGCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGACTCACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACGTTGAAGGAGATGATTAAATCTGGAATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACTCATGAGTACCACGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCTGACCCATCCTCTACCGGCCCGTTGCTGTGGCTCTGGACACTAAGGACCTGAGATCCGAACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTTCAAAATCACGCTGGATAACGCTACATGGAAAAGTGTGACGAGAACATCCTATGGCTGGACTACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTTATTTCTCTCCAGGTGAAGCAGAAGGTGCTGACTTCCTGGTGACGGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAAAAGGACATCCAGATCTGAAGTTTGGGGTCGAGCAGGATGTCGATATGGTGTTTGCGTCGTTCATCCGCAAGGCAGCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAGAAGGGAAAGAACATCAAGATAATCAGCAAATCGAGAATCATGAGGGGGTTCGGAGTTTGATGAAATCCTGGAGGCCAGTGATGGGATCATGGTGGCTCGTGTGATCTAGGCATTGAGATTCCTGCGGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGGCGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAGCCCCGCCCCACCCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTTCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTTGAAGAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGCAGCGTGGAGCTTCTTATAAGTGTTTAGCAGCAGCTTTGATAGTTCTGACGGAGTCTGGCAGGTCTGCTCATCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTTGTGACCGGAATCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCATGAATGTTGGCAAGGCCAGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCGTGATGAACCTGAGAGCCCTTCTCCAGCCCCTGTCCCACCCCCTTCCCCAACCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAAAGTGGCACTGGTGGCTGGGACACCAGGGAAGATTAGTGCCTCGCTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCAGAGCCTGGCTGCCCATCATGTGGCCACCCAATCAAGGGAAGAAGGAGAATGCTGGACTGAGGCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTTCTTTCCTGTGTATACTCCGTCCAGTTCCTTGAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTGGGGTCAGGAAACAGCTAGAGAGTTAGGGGCCTTAGGGCAAGGGCTGTTGTTCCCTTGAAGCTGACTCTGGCCCTGGCCCTTACTTGCTTCCCCAGCCCCCTGGCCTCCCAGTTCGCACCTGTCCCGCCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCGACTACTGCAGCGCCTCCAGGCCTGTTGCTATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAG 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@rCer/680/2063_60_CCS ATGGGGGCTGGCTCGCTGGCCGCTCCTGGAGGCGGCGGCGGGAGCGGAGGGAGCGTAGGGGGTGCGCGGCCCGGGGACTCGCATTCCCCGGTCCCCCTCCACCCCACGCGGCCTGGACCATGGACGCCAGGTGGTGGGCAGTGGTGGTGCTGGCTGCGTTCCCCTCCCTAGGGGCGGGTGGGGAGACTCCCGAAGCCCCTCCGGAGTCATGGACCCAGCTATGGTTCTTCCGATTTTTGGTGAATGCTGCTGGCTATGCCAGCTTTATGGTACCTGGCTACCTCCTGGTGCAGTACTTCAGGCGGAAGAACTACCTGGAGACCGGTAGGGGCCTCTGCTTTCCCCTGGTGAAAGCTTGTGTCTTTGGCAATGAGCCCAAGGCCTCTGATGAGGTTCCCCTGGCGCCCCGAACAGAGGCGGCAGAGACCACCCCGATGTGGCAGGCCCTGAAGCTGCTCTTCTGTGCCACAGGACTCCAGGTATCTTACCTGACTTGGGGTGTGCTGCAGGAAAGAGTGATGACCCGTAGCTATGGGGCCACAGCCACATCACCGGGTGAGCGCTTTACAGACTCGCAGTTCCTGGTGCTAATGAACCGAGTGCTGGCACTGATTGTGGCTGGCCTCTCCTGTGTCCTCTGCAAGCAGCCCCGGCATGGGGCACCCATGTACCGGTACTCCTTTGCGAGTCTGTCCAATGTGCTTAGCAGCTGGTGCCAATACGAAGCTCTTAAGTTCGTCAGCTTCCCCACCCAGGTGCTGGCCAAGGCCTCTAAGGTGATCCCTGTCATGCTGATGGGAAAGCTTGTGTCTCGGCGCAGCTACGAACACTGGGAGTACCTGACAGCCACCCTCATCTCCATCGGGGTCAGCATGTTTCTGCTATCCAGCGGACCAGAGCCCCGCAGCTCTCCGGCCACCACACTCTCAGGCCTCATCTTACTGGCAGGTTATATTGCTTTTGACAGCTTCACTTCAAACTGGCAGGATGCCCTATTTGCCTATAAGATGTCATCGGTGCAGATGATGTTTGGGGTCAATTTCTTCTCCTGCCTCTTCACAGTAGGCTCACTGCTAGAACAGGGGGCCCTCCTGGAGGGAACCCGCTTCATGGGGCGACACAGTGAGTTTGCTGCCCATGCCCTGCTACTCTCCATCTGCTCTGCATGTGGCCAGCTCTTCATCTTTTACACCATTGGGCAGTTCGGGGCTGCTGTCTTCACCATCATCATGACCCTCCGCCAGGCCTTTGCCATCCTTCTTTCCTGCCTTCTCTATGGCCACACTATCACTGTGGTGGGAGGGCTGGGAGTGGCTGTGGTCTTTGCTGCCCTCCTACTCAGAGTCTACGCGCGGGGCCGTCTAAAGCAACGGGGAAAGAAGGCTGTGCCTGTTGAGTCTCCTGTGCAGAAGGTTTGAGGGTGGAGAGGGCCTGAGGGGTGAAGTGAAATAGTCTTCTCACCATTTTCTCCTACTGTAACCCGAGGGAGCTGGCTCAAAGGGCAAAATGCAGGTGTGTTCTCAGTATCATAGACTCTGCAGCAGGGGGTGGGGAGCCCAGGAGGCAGCCTTCCCTTTTGCCTTAAGTCACCCATCTTCCAGCAGGCAGTTTATTCTGAGCCCCAGGGTAGAGATAGTCCTCAGTGAGGGGGAGTTTGGGGTCAAGAGGGCATAGGTAGGTTCCACAGTTCCCCCTCCCAGAAGTTTCCTTAAGTCTTGCCCTAGCTGTGCTCTGCTGCCTTCCAGACTCCCCTCTGCAAATACCTGCATTTCTTACCCTGGTGAGAAAAGCACAAGCGGTGTAGGCTCCAATGCTGCTTTCCCAGGGGGGTGAAGTGAAGATGGTGCTGTGTTGTGGAAAGGGGATGCAGATCCCTGCCCAGCACCACCACCTCCTATGCTCCTGGATCCCTAGGCTCTACTCCATGAGCCTGTTGTAGGTTTTGGTACTTTAGAAATGTAACTTTTTGCTCTTATAATTTTATTTTATTAAATTAAATTACT + EJKKKJCCIKKKKKKKGEKKKJFGIAKFJIKKKJHJ8JIJIIJKFKJ=KGEFG:HEJDJKKBKJIKKJKBKKDKKKFKKKKIKIKGKKKJJKJ?>JJKJKDKKKHKGJKKKKKIJJACKKCFKJKKKHKFIHKKKCKKKKKKKAKKJJKJKKKKJKEIJFIKKKKKKJKBKEKKFKJK=@HKKKK>KIKKKKGIKHIFJK(CHAGKJDJGKKKCGBGJJKJJIKJGKKKKKKJEKKKJJHKEKKKK;IKKKKEKKKKKFKGJKJEJAKKHKIIKKJKKK6KJKJ=KJIKJJJKKGJJIJKJH?@KKFIKIKKJIKGJJKKDKKKKKKJK5JKK>KKJKKFKKKKKKKKKKKJKKJKIGKJKKFJBKJIKK>JKKBKKKJDIKJKJKDIFK9KIKKAAKIJKK@KKIKKKKKKKIKKKKKKJKKJ@IK.KIKK4GKKDKKKIKKKKIKKAKKEKJHGKG@K=JKKFIKJGKHKKKKIDKKKKIKDKK8IKKKKKJ8KJKJK;JKJ@I@KHHKJKIKKKKKKDI;JHHHGKKFKIJ;JKBIKKKEKKJKII@GKKKKKKFKKKK6KJJKKKJKIJKIKHJIKKKIJDE>KKJ@KHKFDKKKKKKIHJKKK8KKKKJKKKKJCKKKKKKKKKGKKKGJKCKKKIJJKHJKFJKJHFEFEIKJKIKKKKKJKKHKKKJKKKKIJJK:FKKJKJFIJKKKKKKKKJJKKHH4JGKK9HGKGKJKGJKKK;IJHIKIEJKJK;JHGIKIE8JKKKAJKKBKJKJKKJ=K8KIJBIJHJCJJJ>KGJHIHHKKKCGEIJHK;FDKD?DCK=KIHFIEKKKJJ4FGJ@JJHGJF78F:=GK$GKJJKDIIE8:KJAJCH9KJIDEIIDHHKI?KK>FKKKJK8EHI8JIBKGKJHKHIJIIHDI??;:BEAAGJKJH0IJIJIJKJ7IFJJKKIBCIHJEGE0IIH?GJIJ>JJFIKFH@IE2IDIJC @rCer/682/1864_60_CCS ATGGGGGTGACTTCTTCGGCCCCCGCATTCGTGGACCGGAGAACCTCACCCGAGAGCGCCGGCGCGACTTCCCTGGCCCCCTACACCTGAGGACCAGAGAACCTCGCCCGAGAGTGTGTGCATATTTGCAATAAAAGACTGCCACTTTCTTACGTACTTTGGCCTCATGTTTTAATTACTTAGCTCTCCTAAATTAAATTAAACAAAACAGCTGGTGCCGAAACCCGACCCGGGAAGAGACCCTTCCTCAACATCCCCTAGGGGTCTGAGGAACCTCCTCGCCAGCGAACCGGCTCCCAACCCAACCAGCCACCAACACCGAACAAGTGTTCCAGCTTTCCACTGGTGCCGCTCTGAGCATTTCTTCTTCGGTGAGTACTCCCCTTTGTTAACCATCTCCGTCCGTTTCCCTGTCCTTGGCCTGGAGTCGTGCGCACGCCCAAGGACGTAGCCACCCTGTGGCGCAGTGAGGCCTTCAACCCGGACACGTCCGTCTTGAAGTTCCTCAATTCTCCGTTAGTGGCTCCAGGAGCCCCCGGTCTCTAGCAGCGGCAAAGGACGCTTTGCCACTGCGTGAGGTCGGTTTCCATTTCTGGTGGTTAAACAATGGGAACCTCACAATCCAAAATCCCTAGGAACACCCCCTTAAGGTGTCTCCTCCAAAACTTGGAAGCCTTACATTTAGCTCAAGATTTAAAACGAAAGCGGCTAATTTTCCTCTCCACAGTGGCATGGCCGCAGTATAAATTAGACAACCAGTATCAATGGCCACCAGACGGCACACTTGACTATAACATTCTATTAGATCTCTCTAATTTCTGCCAAAGGCTTGGAAAGTGGTCAGAGATTATCTATGTCCAAGGCTTTTAGGACTTGCGCTCTCGCCCAGACCTGTGTGCCCAGTGTTCAATGGCCCAGGTCTTGTTAGCTAAAACCCAGCCCTTGGCCCCCACACCACAAGCGGAGGAAGATTCTACTTCCATCTCAGATGGGGCCGACGTTCCCGACCTACCAACCCCCTCCCTATGCTCCTCCTACCGCCCCTCCCTCACCCACTCCTCTTACCTCTCCCATTTCCGCCCACACTCGCTCCAAGACCGCGGTAGCGGCCCCCACTAGTCAGCCCTCTACCAGTCAGCCTGCCCCAACCCCCTCTACCAGTCAGCCTGTCTTAACCTACCCTACTGGTCAGTCTGTTCCAACCTCCCCTGCTAGTTTGTTGGCCCCCCTCCAAGAAGTTGCTGGAGCTGAGGGCGTGGTTAGAGTCCACATCTCCTTTTCCCTGGCTGACCTTTCCAAAATTGAAGAACGACTCGGCGACTTCTCAGCCAACCCCACCCAATATTCCAAAGAGTTTCGATACCTAGGCCAGGCATATGACCTTACCTGGCATGACTTACATGTCATTCTTACTTCCACTCTTAACCCAGAGGAAAGAGAGCGCATTCTTGCAGCCGCCAGGCAGCATGCAGACCAGTTACACTTAACTGACCCTGCCAGCCCAGTAGGCGAACAAGCTGTCCCATCTACAGATCCTGAATGGGACTACCAACCTCAACAACCCGGGCATCGCAGAAGAGACCTTATGATACAATGTCTCTTAGCTGGCATGCAGGCAGCCTCTAACAAAATAGTAAATTTTAATAAGTTACGGGAGGTTATTCAATACTCAGAGGAAAACCTGCCTCCTTTTTTAAATCGCCTTACAGAGGCACTTGTACAACTTACCCAACTGGATCCTACCTCTCTGGCAGGAGCTACTGTCCTTGCCACTTATTTTATTTCCCAGTCGGCCCCTGACATC + <8<:66/8184<+764<:7=7<=4=:3:.892?3976?;:96/93:==9;(<>=887884:;18;47;<9=:40<4:9<;+7304502708->?=6>:783:;=9=9=48978>8:;==64<948929<=:;=6<5<9>=:?:<>:>14>51:=68<;;2<3?831<99:51#;/6/49?87?;3:301@?A5>6>:,;.@/>;=:(>:/7?:>>?)@B<@3CB<<4540;35?CA.=B?:;<.?>7=:?@6;C=;6>6?:=?@<819=:B;@=A:<;:.<>=A9>=3@<;@C;>:8?6>=@:484=@1;@?BB9;>>:9?;@BB=>-B;:=8:-9;97.>;6B?@=6:>9;=@=@7?4@>5C>7>13?:?<8C=89=C;:>85/2A6;@B3@9B9::=>3<85A?BAA;->:7=A@?A7C;>:5?55;?>@A?6@=@.C>>0;6=:378-A92><=;A;>+:=<=?;.:4=??7><.38608/9:*894?;@<>1=8;BA787=@B>BA:>5A-A=>7426;<@=AB;BB@.>;8<57+758?43?=:A98<=::C8A>@:3@@@4;8@?1=2>?>@;79;<2=*<>@?7A=>7A747037/:89;?8;/736;6<;=;,186;%:>?;;<;<6A=:99C8>=<15=A0<48-@>598:557=<:;>95.AC7A<;39<81<5<<7>6;;2A=@9<@99?8>A3;<;247;:A996>:=???/<1>A>;>=@>@5=?=:?=7-;@?:?@AB@:@<:94AA>:==7?@7@?:;97?@7=;86&A@35=>A6B72+==?>&668B2/><;=@B@=C??=9<;@8>C@C>?1<99A=6;?>@A@4C;<;<8A;@;76?A176@?A36;?:)8:8-7<9258:+02)<9959A>@18;?39:46<@$37ACC><:?;35?B:@.A27:@==4=:227A?:=AC94:>AA3?=9.;=192>??29A8AA>C>>?AA?7:'7>792;<.%A=7@>B==:2:@;A@8<0A<637;36;@7?54;69;28>9;?7<7@77=BB1@=8<>B>:5??8C4AC@?=3@?7@3?C==C:A?4B;;@9/;;8>(79?B3@?6:=?=4:;<:B@>C<:<6%?37<3=@@B89;=>CAA@@BA8@A/>89?@'>>:';49>;6<-AA7<;=C?69?,;>B;98==<)@@8==;@<=B?=?98B5:<9=@<@2@;582<==;:7>:>A<=@6/:49?6:B@@1?=.=95=8?A6@=>B@;>=?@.5<?6??<<=2;@:>?=/<>@4>?:5@=A7;42=;?1A?>7=?<6-=@59>56@:;@9?@.;==8>@7:==3'=;A:A<;=A@58992B@B791>==:@?8=<2<=5546B>@1=?>?><9@9B<;3<9??6A7<:*:=A;:;>?:B8<)=59>A==49A;C<;@>BAAB39=B5;;6B;C7B=91.-(9+:?>?>579?=6@<;;;><9&9<.>7?=BC=8@9>64-;:9?::5;@826>6=@=6C@A7A=A?C@B3C;;<@CAC=??A<76=8)> @rCer/683/1779_56_CCS ATGGGGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCGGCACCCAGGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGAGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAATTGGGCCTGGGAGGCGGGTCCGGAGAGGGCTACGGAAAGCCCCCGGCCGGGAAGCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGGCCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTAGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAATTGGACGCTGGTGACCAAGACCTACTGGGCTTCCTGCTAGAGGAAAGTGGAGATTTGAGGACGGCGCCCGATGAGTCCGTGAGGGCCCCACTGGACTGGGAGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAGGTAGATGATTTGCTGAGCTCCCTGCTGAGTCCCCCAGCGTCGTCGTTGAACGTTCTCAGCAACTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGAGAACCTGTCTCTATGGATCTAGAGAGTGAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGATATTGTTAGGCTGGTACTGACAGATGAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGATGGAGGAACAAATTCTGAAACGTGTGCGGAGGAAGATTCGAAATAAAAGATCTGCTCAAGAGAGCCGCAGGAAAAAGAAGGTGTATGTTGGGGGTTTAGAGAGCAGGGTCTTGAAATACACAGCCCAGAATATGGAGCTTCAGAACAAAGTACAGCTTCTGGAGGAACAGAATTTGTCCCTTCTACATCAACTGAGGAAACTCCAGGCCATGGTGATTGAGATATCAAACAAAACGAGCAGTAGCAGCACCTGCATCTTGGTCCTACTAGTCTCCTTCTGCCTCCTCCTTGTACCTGCTATGTACTCCTCTGACACAAGGGGGAGCCTGCCAGCTGAGCATGGAGTGTTGTCCCGCCAGCTTCGTGCCCTCCCCAGTGAGAACCCTTACCAGCTGGAGTTGCCTGCCCTGCAGTCAGAGGTGCCAAAAGACTGCACACACCAGTGGCTGGACAGCTCAGACCACGTACTCCAGGCCCCTGGCAACTCTTCCTGCCTACTGTACTACATGCCTCAGGCTCCCAGTGCAGAGCCTCCCCTGGAGTGGCCATTCCCTGACCTCTTCTCAGAGCCTCTCTGCCGAGGTCCCATCCTCCCCCTGCAGGCAAATCTCACAAGGAAGGGGGGATGGCTTCCTACCGGTAGCCCCTCTGTCATCTTGCAGGACAGATACTCAGGCTAGATATGAGGATATGTGGGGGGGGTCTCAGCAAGAGCTTGTGGGGCTCCCCATCTGTGTCCAAATAAAAAGGGGTGGGCGAGGGCTGGCTGCAGCTCCTATGCCCTATCAGGAGGACTGAGGGCTCAAACACACCACACTTACTGGCTTTCTGGGTCTTTTATTTGTACCCATGTGTCTCACCCCATGAATGTACCTGGGGAAATCAACTGACCTCCCTGAACATTTCATGCAGTGAGGGAACGGGTGAGGAAAGAAATAAATAAGTGATT + JJKKK;KKJKKKKJKKKKKHKGIKKKKKKKKKGKJKKKKKHKKKKKKKKKKKJKKKK7KKKHIKKHKKKKJKJKKKKKKKJKKKKKKJKKKKKEKIKKKIKBKKKKKKKJKKJKKKKJEKKKKKKKHKKKKIKKKKKJKKKKKKKKKKKKKFKKKKKKKJJKIKKK>KHKKJKKKKKKKKKKKKKKKKKJHKKKKJKKJKKKKKJKKKKKIKIKJKKKKHJKKHKKKJKJKJKKKIKKKKKKKKKKKHKKKK?KKKKKKKKKKKKKKIKFJKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKHKJKKKK>KKKEIKKAKKJKKKKKKKKKIKKKKKKKKAKKKKKKKKKKKGJKKKKKKKKKKKK8DJKKKKKKKKFKKKKKKKKKKKIKJKK@KDKIKKKKKGKKKKKKKHKKKKFKIKKKKKKJKKKIKKJKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKEKKKKKKKKKKKGKKKKKKKKKKKKJKKKK*KKKKKKKKKKKKKKKKKKKKKKK?KKKKIKKKKJKIKKJKKK7JKKKJKK=KKKKKKKKKIKKKKKKKJKKKKKIJKAKIKJKKKKIKKKKEKKKCKKKKKKHKKJKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKJJJKKKFJKK?KKKKKKKKKKKJJJKKKKKKKKKKKKKIKKJKKJKKKKKKKJKKKK7KKFKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKJKKKKKKKKKKHIKKKK3IKKKKKKKKKKJJKKHHKKKKKKFKKKKHKJ@CKKKKKKCKKJKKKKKKKKKKKKKKKKKIJKKKKJKEKIKKJKKKKKKKKKKKJKKKKKKHKKKBKKKKKKJKJKBKK @rCer/684/0_2166_CCS TTTCATGGACTTTCGGCAGCTGGGAAAGACACACAAAAGGAATTGGACAGAAGCTTCTTCAGAAGATGGGCTACGTCCTGACGGGGCCTTGGAAGAATGCACAAGGTATCATTAACCCAATCGAAGCCAAGCAGCAGAAAGGGAAAAGGTGCTGTGGGGCTTATGGATCCGAGCGCACCACGCAGTCAATGCAAGACTTCCTGTGGTTGACTCAGAGGAAGAAGCTGAAGAGGAGTTTCAGAAGGAGCTGAGCCAGTGGAGGAAAGACCCAAGTGGAAGCAAGAAGAAGCCCAAATACTCTTACAAGACCGTGGAAGAGTTGAAGGCCAAGGGCAGGATTAGCAAGAAGCTCACTGCTCCCCAGAAGGAGCTTTCTCAAGTCAAGGTCATAGACATGACAGGCCGGGAGCAAAAGGTCTACTACAGCTACAGTCAGATCAGCCACAAGCACAACGTTCCCGACGATGGGCTGCCGCTGCAGTCCCAACAGCTGCCACAGTCTGGCAAAGAGGCCAAGGCCCCGGGCTTTGCGCTGCCCGAGCTGGAGCACAACCTGCAGCTGCTCATTGACCTCACGGAGCAGGAGATCATCCAGAATGACCGCAGCTACAGTATGAAGCGGACATGGTGGTCAACCTCTTCCACGAGCTGGAGAAGATGACCGAGGTCCTGGACCATGAGGAGCGGGTCATCTCCAACCTCAGCAAGGTCCTGGAGATGGTGGAGGAGTGCGAGCGGCGGATGCAGCCGACTGCAGCAACCCCCTCACCCTGGACGAGTGTGCCCGCATCTTCGAAACCCTGCAGGACAAGTACTATGAGGAGTACAGGATGTCGACCGTGTGGACCTCGCCGTGGCCATCGTCTATCCACTCATGAAGGAGTACTTCAAGGAGTGGGATCCCCTCAAAGACTGCACTTACGGCACCGAGATAATCTCCAAGTGGAAAAGCCTCCTGGAGAATGACCAGCTCTTGTCTCACGGCGGACAGGACCTCTCGGCAGATGCCTTTCACAGTTGATATGGGAAGTCTGGATGCCTTTTGTTCGAAATATTGTCACTCAGTGGCAGCCAAGGAACTGTGACCCGATGGTGGACTTTTTGGATAGTTGGGTGCACATCATTCCTGTGTGGATCTTAGATAACATACTGGACCAACTCATCTTCCCCAAGCTGCAAAAGGAGGTGGGAAAACTGGAACCCGCTCACAGACACTGTTCCCATCCACTCTTGGATCCACCATGGTTGCCCTTATGCAGGCACGGCTGGAGCCGCTCTATTCCCCCATCCGTAGCAAGCTGTCCAGTGCCTGCAGAAGTGGCACCCAGTGACTCCTCTGCCAAGCTTATCCTCCAGCCCTGGAAGGATGTCTTCACTCCTGGCTCCTGGAAGCATTCATGGTCAAAAACATAGTGCCCAAGCTGGGGATGTGTCTTGGTGAGCTAGTCATTAACCCCCACCAGCAGCACATGGATGCATTCTATTGGGTGATCGACTGGAGGGATGATCTCTGTCTCTAGTCTGGTGGGACTTCTTGAAAAGCACTTCTTCCCCAAGTGGCTTCAGGTGCTGTGCTCTTGGCTCAGTAACAGCCCAAATTATGAGGAGATCACCAAGTGGTACCTGGGTTGGAAGTCTATGTTCTCAGACCAAGTGCTGGCACATCCATCTGTCAAGGACAAATTTAACGAGGCACTTGATATCATGAACCGGGCGTGTCCTCCAATGTTGGTGCCTACATGCAGCCAGGCGCGCGGGAGAACATTGCCTATCTCACCCACACGGAGCGGAGGAAGGACTTCCAGTACGAGGCCATGCAGGAGAGGCGGGAGGCTGAGAACATGGCCCAGAGGGGCATTGGCGTGGCCGCCAGCTCTGTGCCCATGAACTTTAAGGACCTCATTGAGACCAAGCTGAGGAGCACAACATTGTCTTCATGCCCGTCATTGGGAAGCGACACGAAGGGAAGCAGCTCTAACACCTTTGGCCGCATTGTGATCTACATCGACCGGGGAGTGGTCTTTGTCCAGGGCGGAGAAGACATGGGTGCCCACCTCACTGCAGAGCCTGATCGACATGGCCAAGTGAACTGTGGCAGGCCCAGAGCCAGCCAGAGACTTGCCCCTGAGAGGGATGTGTTGTGAATAACGGTATTTTAGATCACCT + S)),-*(-,+#'&(,-,(01-'-,(11,,0,0.**120)-*/*.'+00*.&.0,0201210-/3,..00.-',0.)+.'%,*&)431++6+.,931864-',*,)1-313/04.940937001'2103-1.,)0$$$#*+148295:27.191,*&+,,4*5022437&/4,5802.42%10366/%*-2.0/33$274%5)46-82/.0.,2332-71381,4::522:4+7;95>>=-.-6,7./114<97==542=;3;+953;38>=:9>5>5767.;6,8/.8:/?7))203&1206393683)-08387;6/779/25*4+22;'68722<8/:3;-7?9/7:::2259741'62374871:=<8'.1/./-58:;;?385-1299<<3;7).('6.2,57:6=9967/6457*;88=.7923126<<;8<>6:;-9+8796594044427+,26<;>7..9:::92.35781464;9.4*38:37223..+895987=:;>726;6349-(0048+83;8:=39<9048-)+,7>9729--75<)74*85::1070678777.3159:?972(6::9%-1775,594:>6+5,7408:)19:56440-,1104,.552*3010;2:2<<7593*..1+,*-3+327/1-)02,2/0/2.89-6:95165/902/-58-40).0/23:65./*#/0*-394&/53:4495,9.75-2*953.-469//12-*202/,05-)5629508-57771/43.20-8(86-3//3-/:4/%.02736048752.8/3.5/:952)-5392+/64775993:6810+02+&+2447/&,+7501745'+)4266:35.325970455..($+)*11223,74:%123/44751.3(2/6*..,,/52094502/327-+,77+15//314.&4.-1123.03386:5:73,/.4229237...6'400/1-354*0,/-1,*.8-.1-496'5)/255+',411)+'()-/),/)+/4123.04,21*.-0+0/1-/,+,/3-(5/58645//(/4-/3/0101544.4.&*)143(&,0*1.33+&),%+.1*/2-0&./23,//1333/0../-.&2+2//+-)++'$1.&()-#'),.+'-''))-*0+451.25/43)/21/7:&34244.)%--0'2'-0*,)-0-/+./5/2.-*&%&)',1.,55554(3/92-787&/1433/0.(*-132.3*)+')+0/43325,-*&,+%),,)%*+(0&)02+)4/)41)03352/4022*,2*-/574/1/300/57537400332042/4/:323/530718/,324442310++14*+4333)1-823'98/40-1030+3*.549884456473*-)+&'%(&-75351274455660+50*8+6754..&2244%-101//*+$'+(-30.271130*&121&0'+*,.3878:3:./5436:96253736.02**00./3795--8835.78&5,2,5/57748;931-87773,2-32456399;:8:4:26/1022*6-23+--4.4053;63;9+728525-3:9:/3434:06&.11*36141(1/84356259.6+564/786222)/&/3477/85853364,/1+/024531+($%&-)(.43%,%+.5120.1-36477/89*7515-44660-%*54)3526979.:87%+121425/00(')04(/59125/83.2426452644486:941:9;,:3758:/91274/699-6-9:27465/15,6151&02.35,3:950,121820(..*(33.4*.,&42$)(,&-/000,,11121 @rCer/687/25_1724_CCS CTGGCTTTACTATGGCGGTTGGAGGAACGGCAGTGATCACACGTCGTCTGCTGGGAAGATCTGGATTCTCGTTTCAGGTCACCATCAGAAAAGCTAAGTTTGCTGTATAGTGAGGATCAGGAGGTCTGATCCTGATTGCAGAACCTTCCCTGATTACAGAATCTTGGTGGTTGGAATAAAAACAGGGTTGAATGAGTTCCAGAAAGCAGGGTTCTCAACCTCGTGGACAGCAATCTGCAGAAGAAGAGAACTTCAAAAACCAACTAGAAGCAACATGCAGAGAAGTAAGATGAGAGGGGCCTCCTCGGGAAAGAAGACAGCTGGTCCACAGCAGAAAAATCTTGAACCAGCTCTCCCAGGAAGATGGGGGGTCGCTCTGCAGAGAATCCCCTTCAGGATCCGTGAGGAAGACCAGAAAGAACAAACAGAAGACTCCTGGAAACGGAGATGGTGGCAGTACCAGCGAAGCACCTCAGCCCCTCGGAAGAAAAGGGCCGGGCAGACCCCACTGTTGAAAGTGAGGAGGCGTTTAAGAATAGAATGGAGGTTAAAGTGAAGATTCCTGAAGAATTAAAACCATGGCTTGTTGAGGACTGGGACTTAGTTACCAGGCAGAAGCAGCTGTTTCAACTCCCTGCTAAGAAAAATGTAGATGCAATTCTGGAGGAGTATGCAAATTGCAAGAAGTCGCAGGAAATGTTGATAATAAGGAATATGCAGTTAATGAAGTTGTGGCAGGAATAAAAGAATATTTCAATGTGATGTTGGGCACTCAGCTGCTCTACAAATTTGAGAGCCCCAGTATGCTGAAATCCTCTTGGCTCACCCTGATGCTCCAATGTCTCAGGTTTATGGAGCACCACACCTACTGAGATTATTTGTAAGAATTGGAGCAATGTTGGCCTATACGCCCCTTGATGAGAAAAGCCTTGCATTATTGTTGGGCTATTTGCATGATTTCCTAAAATATCTGGCAAAGAATTCTGCATCTCTCTTTACTGCCAGTGATTACAAAGTGGCTTCTGCTGAGTACCACCGCAAAGCCCTGTGAGCGTCTACAGACAGCTCACCATTTTTGTCCTGTATCTGTAAACACTTTTTGTTCTTAGTCTTTTTCTTGTAAAATTGATGTTCTTTAAAATCGTTAATGTATAACAGGCTTATGTTTCAGTTTGTTTTCTGTTCTGTTTTAAACAGAAAATAAAAGGAGTGTAAGCTCCTTTCTCATTTCAAAGTTGCTACCAGTGTATGCAGTAATTAGAACAAAGAAGAAACAGTAGAACATTTTATTGCCTAGTTGACAACATTGCTTGAATGCTGGTGGTTCCTATCCCTTTGACACTACACAATTTTCTAATATGTGTTAATGCTACGTGACAAAACGCCCTGATTCCTAGTGCCAAAGGTTCAACTTAATGTATATACCTGAAAACCCATGCATTTGTGCTCTTTTTTTTTTTATGGTGCTTGAAGTAAAACAGCCCATCCTCTGCAAGTCCATCTATGTTGTTCTTAAGCATTCTATCTTTGCTCAAATTGTTGAAGGATGGTGATTTGTTTCATGGTTTTTGTATTTGAGTCTAATGCACGTTCTAACATGATAGAGGCAATGCATTATTGTGTAGCCACGGTTTTCTGGAAAAGTTGATATTTTAGGAATTGTATTTCAGATCTTAAATAAAATTTGTTTCTAAATTTC + KK?KKEKKKKKKKDKK6KIK3KKKKKKK.KKKKBKKKEKK-K/KKKKKK@KKKKKKKKKKKKKKKKKKKKHKKKDKKJKKKKKKKKKKKKKJKKKBKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKJKKHKKKKKKIKKKKGKKKKKKKKJKKGKKGKKKKKKKKKKKKKFKKKIKKK4KKKKKKKKKHKKKKKKKKKKKKKIKKKKKKKKJKKKKFKKKHKK;KKKKKKKKKKJKKK#KIKKKKKKKKKIKKKKFKKKKKKKKKKKKKKKKKKKKKKKIKKK=KKKK?KKKKKKKKKKKKKKKKKKKKKBKGKKKKKKKKKKKKKKKK?KJKKJKKKKKK%.GKKKKKKKKKKKKKKK?KKKKKIKKKKK'KKKKKKKJKJKKKKKKKKKKJKKKKKKGKKKHJAKKKK2KKKKKKKKKKKK2KKKKKKKKK=KJKKKKHKKKBK>KKKKKKKKK=KKKKKKKKKKK3KKKKHKKKKKKKKKKKKKK7KKKKKKKKKKKKKKKKKJKKJKKKKKKKKJKKDKKK/KJKKKKKKKKKKKKKKKKKKKHKKKKKKKKJKIKKKK;KKKKKKKKKKKIKKJKKKKKKIKKK2KKKKKKKKKKKKKKKKKKKKKHKKKIKKBKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKKKKKKKKKHKKKKKKKKKJKKKJKKKKKKKKGKKKKKKKKKJKKKKKKKKKKKK&KKJKKKKKKKKKKIKKKJKKKKKKKKKAK9KKKJKKKKKIKKKKKKKKKKKKKKKKKK5KGKKKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKJKKKKKKKKKKK>KKKKKKKAKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKFKDKKKKKKKKKK5KKKKKKKKHKKKKKKKKKKKKKKKKKKK3KKKDKKKIKKKKKKKBKKJ @rCer/688/24_2117_CCS ATGGGGTGTGCATCACCGCGCCGGGACCGCGGCTCTGGAACGCGGCGGAGACGATGCCTGAGATCAGAGTCACGCCTTGGGGCTGGCCAGGATGTGGGCCGAAGCTGCATCCTGGTCTCCATGCGGGCAGAAGTCATGCTGGACGCGGAATGCACATGGCTTCAATGACGACCGACTTCCCTGACTTCTCCTACATCACCCAGAACGGCCGCCTGACAGACTTCCTGGACTGCGTGATCATCAGCCACTTCCACCTGGACCATTGCGGGGCACTCCCCTACTTCAGCGAGATGGTGGGCTACGACGGGCCCATCTACATGACCCACCCCACCCAGGCCATCTGCCCCACTTGCTGGAGGATACCGCAAGATCGCCGTGGACAAGAGGCGAGGCCAATTCTTCACCTCCCAGATGATCAAAGACTGCATGAAGAAGGTGGTGGCTGTCCACCTCACCAGACGGTCCAGGTGGACGATGAACTGGAGATCAAGGCCTACTATGCAGGCCACGTGCTGGGGGCAGCCATGTTCCAGATTAAAGTGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGACCGACACTTGGGAGCTGCCTGGATGACAAGTGCCGCCCCAACCTGCTCATCACGGAGTCCACGTACGCCACAACCATCCGCGACTCCAAGCGCTGCCGGAGCGAGACTTCCTGAAGAAAGCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTGATCCCCGTGTTCGCGCTGGGCCGCGCCCAGGAGCTCTGCATCCTCCTGGAGACTTCTGGGAGCGCATGAACCTGAAGTGCCCATCTACTTCTCACGGGGCCTGACCGAGAAGGCAACCACTACTACAAGCTGTTCATCCCCTGGACCAACCAGAAGATCCGCAAGACTTCGTGCAGAGGAACATGTTCGAGTTCAAGCACATCAAGGCCTTTGACCGGGCTTTCGCTGACAACCCAGGGCCGATGGTTGTATTTGCTACGCCAGGGATGTTGCACGCCGGGCAGTCCCTGCAGATCTTCCGGAAATGGGCCGGAATGAAAAGAACATTGGTCATCATGCCCGGCTACTGCGTGCAGGGCACCGTGGGCCACAAGATCCTCAGCCGGGCAGCGGAAGCTGGAGATGGAGGGGCGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGACGCCAAGGGCATCATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGTTGCTGGTGCATGGCGAGGCCAAGAAGATGGAGTTCCTGAAGCAGAAGATCGAGCAGGAGCTCCGGGTCAGCTGCTACATGCCGGCCAATGGCGAGACGGTGACGCTGCCACGAGCCCCAGCATCCCCGTAGGCATCTCATTGGACTGCTGAAGCGGGAAATGGCGCAGGGGCTGCTCCCGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGATCATTGAAGGACAGCAACTTCCGGCTGGTATCCTCAGAGCAAGCCTCAAAGAGCTGGGTCTGGCCGAGCACCAGCTGCGCTTCACCTGCCGCGTGCACCTGCACGACACGCGCAGGAGCAGGAGATGGCGTTGCGCGTCTACAGCCACCTCAAGAGCGTCCTGAAGGACCACTGTGTGCAGCACCTCCCGGACGGCTCTGTGACTGTGGAGTCCATCCTCATCCAGGCCGCCGCCCCTTCTGAGGACCCGGGCACCAAGGTGCTGCTGGTCTCCTGGACCTACCAGGACGAGAGCTGGTAGCTTCCCTCACATCTCTGTGAAGAAGGCCTCCCCCAGGCCCCCAGCTGAGGCCGGCATCTCACCCAGCCACCACCTCTGCCCTCTCCAGCTGACAGAGCTGGCCTGCACTCAGACTGTGGGTGCCCTGAGTGAACAGACCCTCAGGTCCCGTCCCGGGACAGAGACCGTGTGTCATGTGCCACCCAGGCAGCTGTTTCCAGCTAAAGAAAAACTGGCCTCCGGGCTGTCTTTGCCTTTATTCCTGCTCCTGGGCCCCAACGATGGTTAGGGCAGGAGTCCCGGACATGCAGTTCCAGTAAAAGCTGAACGAAAGG + *-),-**(***')+&'())*""&()*#$+-,-')+*#+*.----,,&+*(+,,,,*(,+'-,)--)*)*---,+$,%*%++((&))(.,%+#%%'$*+*-*,---,+%'()----%'+'%(#*-'*++&&#$#'((,+--+($%#)%'&+,-,(*,'#+(',('(()&))+)&,#""&)--,--),*--*(#$*-*-,#*++(()((()-,&+,--*,*,-+-',,)-(''*,)'$&),-,)))#**,)-')+)+&'--+-)+.-+(-,,)'((%'&)+-')-------+--)**(-,'#(-,$+,.-(,)')+((,----,..,&,+,,),*,),&+(,-,)*(..'#),)**(,+&($$((-,'&-(*)+()*$',-,(*-)(&-,,)$(',(($-)()*+)'''',)),+')--'--)+-,-)),-'))))+-)+.,)-,)--)*,,-+#*-*+&(+()&(*-+,''++,*---(+(+-.-,--*'++,%-,-+,,)+(-,-+-('+)+)($+,*,''+),((-+**.,*-,-*+)++$,'+,*-*---+(-),)&)('(-+..,&+',(,-.-'((''+-,+-,&,'&-()()*,,*'(**,,+'(%$*)+),'(&+.)(++-)-,-*,)*--*,--)--+&%'),-)'(')+&''-$)(''-,,*-+'',,.-,(),)%"%.,---+#)+),(,(((,-,..+#)''&'(*),,)'-&+,',-.,&,++.(+)+---,)',--,+,)--,--)*(,'&)(--(**'+-+-')+--*,-)-,))*,.,((#*.,,)*(++$+,+)++-(--,'&$()&-.)),---%',(#)-',--#*,)),-(+(#(+*#),&+,),)(,--,.-,'+-.--)(-))'(--*.+.-.--),+---.-),.--+#+*---*,-+*-+.,++,()((,,+.-),(+,,)('&&&.,,&,,(,02'/00.1210/1,0,%/022-)111211-&/02111.12--'*1112,,1.1/.,1+0-,*.2,21,)-0%/./1,'.111+0-,*.'///,11.0'(%0,-(111/,2+($,12-/,,-/,,&/,+10.'1111+'.11&,-1.1210(+)*//-)0/''(.,)).%/*11.'0/*/)011101(/,0+1,/12..,0,012.,.112/,1/$*.1.11.+'+,,0)*.+0,111-1/21--11,,+011-,111102+2/22))*.-011.1.+-20%//-1-/21/-*/.1,*./'0.-0*,/-+%,,#-+-&*0011*1.1%./12.,*-2*+'0,.--10.11*121-111110'02-01.12+111-...11/,,-1(,%-0212,1+1.111//0&,.-,-,,0.&0-1/,,.222-*.0*+12110--211.-,**(-%,*,0/,/*+111-20&///121111+0.1,.-+%+2001-1,/).0-2++101+0/)+-11.-0+0+-022--0-10%-,/-,-/0*1/#//-1.2,11/(,(*)*/,0..)-.121'/..)11/,0,.-220,/,1/211111.21'+011..)0/&',-1,1111+,/0'+(-1/100**-111+$+010+0*0&0+-1211+011-10+,-*,)0.10+0-1.2.11.11.111(/)0,*-%//1011-0,11-.1&&-00211+/111.111.%+,00..'*,100+..1-*+2/-2*..,-,%00+-10.0.-2-*01+010.-0*0,1-/&&-0.,/&+.*0++21-*(/100*0011,#&'$'$+),--).#(+,(-,&,,-++*"+*-),+#*%'('-,+***-(---+(,-,--+-(+&))-('+*+)*)'&#+&$$'),')('$(()'&$-'&('#$('"##'(&'&)))(&'$)'#%)))(#(&&()---,)&'**-(()*(++(,+&-((.-()&*&"*('((%&+)&+(+%(-+$)#(,(%,&(&,*(-------(-)''&+((*,*((*&$$(*(*#'%%)%(%()&#($%+-(-(),+&)$(,,),),$&-+(*++$*),'&,.,,,,.,-)#(%%$$*('(()%#&(%*&'#&+'*&,------),*,(,,'* @rCer/690/25_2262_CCS ATGGGAGGGCTGAAGCGGCGGCGGCGGTGGGGACTGCACGTAGCCAGCGCTCGGCATGGCTCTCCTGGGCTTGGTCTGGTGAGCTGTGCCTTCTTTCTGGCAGTGAATGGTCTGTATTCCTCTAGTGACGATGTGATCGAATTAACTCCATCAAATTTCAACCGAGAAGTTATTCAGAGTGATAGTTTGTGGCTTGTAGAATTCTATGCTCCATGGTGTGGTCACTGTCAAAGATTAACACCAGAATGGAAGAAAGCAGCAACTGCATTAAAAGATGTTGTCAAAGTTGGTGCAGTTGATGCAGATAAGCATCAGTCCCTAGGAGGTCAGTATGGTGTTCAGGGATTTCCTACCATTAAGATTTTTGGATCCAACAAAAACAGACCAGAAGATTACCAAGGTGGCAGAACTGGTGAAGCCATCGTAGATGCTGCGCTCAGTGCTCTGCGCCAGCTTGTGAAGGATCGCCTCGGGGACGGAGCGGAGGATACAGTTCTGGAAAACAAGGCAGAAGTGATAGTTCAAGTAAGAAGGATGTGATTGAGCTGACAGATGACAGCTTTGATGAGAATGTTCTGGACAGTGAAGATGTTTGGATGGTTGAGTTCTATGCTCCTTGGTGTGGACACTGCAAAAACCTAGAGCCAGAGTGGGCTGCCGCAGCTTCAGAAGTAAAAGAGCAGACGAAAGGAAAAGTGAAACTGGCAGCTGTGGATGCTACCGTCAATCAGGTTCTAGCCTCCCGCTACGGATTAGAGGATTTCCTACAATCAAGATATTTCAGAAAGGCGAGTCTCCTGTGGATTACGACGGTGGGCGGACAAGATCCGACATAGTGTCCCGGGCCCTTGATTTGTTTTCTGATAACGCCCCACCTCCTGAACTGCTTGAGATTATCAACGAGGACATTGCCAAGAGGACGTGTGAGGAGCACCAGCTCTGTGTTGTGGCTGTGCTACCGCATATCCTTGATACTGGAGCTGCAGGCCGAAATTCTTATCTGGAAGTTCTTCTGAAGATGGCAGACAAATACAAAAAGAAAATGTGGGGGTGGCTGTGGACAGAAGCCGGAGCCCAGTCTGAACTTGAGACCGCGCTGGGGATTGGCGGGTTTGGGTACCCGCCATGGCCGCCATCAATGCACGCAAGATGAAATTTGCTCTGCTGAAAGGCTCCTTCAGTGAGCAAGGCATTAACGAATTTCTCAGGGAGCTCTCTTTTGGGCGTGGCTCCACGGCACCTGTAGGAGGCGGGGCTTTCCCTACCATCGTTGAGAGAGAGCCTTGGGACGGCAGGGATGGCGAGCTTCCCGTGGAGGATGACATTGACCTCAGTGATGTGGAACTTGATGACTTGGGGAAAGATGAGTTGTGAGAGCCACAACAGAGGCTTCAGACCATTTTCTTTTCTTGGGAGCCAGCGGATTTTTCCAGCAGTGAAGGGACATTGTCTACGATCAGATGACTCTCCAGTGGCCTTTTAACCAAGAAGTAGTACTTGATTGGTCATTTGACAACACTGCAACAGTGAACTTTTGCATCTCAAGAAAACATTGAAAAATTCTATGAATTGTTGTAGCCGGTGAATTGTATCGTATTCTGTCACATTAATATTTTGAAGAAAACTCGGCTGTCGAAACGTTTTTCCCTCTCTCTGACTGCTGCTTGGATGTTCTTGGAGGCTGTTTCTTATGTATGGGTTTTTTAATGTGATTCCTTCATTTGAATATTAATGGCTTTTTCCATTAAAGAATAAAATATTTGGATAATGCCGATAAATGTATGAAATTAGTATCTACATCATAAATTCAGAGTGATGTTTAGCAGTAAATTAATATTTTGAAGTGATACACAGATATCTTTCCTCCCCACAAACTTTTTTAAACAAAAAACAAGATCTCTTTGCTTCAGATGGTGCCATCAATGCCTCCCCACAACAGAGATTTTACATGGAAACCGGACTCAGTGAGCACTGATTTCCCGCCCAATATTGTCTTTGGGCTGTCTCTAGTGACTAATTATTAAGGAATCTAGCTGGTTATACAGTGCAAGGCTTTCTATGTTGTTATGAACCTCAGAATAGCCATTAAGACATGAAATACAGCAGCAGGTTACCAATGCGAACACATAGTTCGCATTTATGTAAAACATTCAGAAAAATGAAGTTTTGAATTTGTTAGAACCTTCAAAGGACTTGAGAGCATTTTATTGTAACTTAAAAAAATAAATACAACTGTC + /<$<4;8A?@31:5A@=<@@?=8@@?<;C>><:39A'D>7:F9;534=A6@3=AA;:>>/;;:?B@BB>=;59,9(9<=?;;9;BAD:D=?E@=A??:58;<:@=:52,;=398/7>1=;6;AA@5=)A01+979>:AA=29>E7BCB=2A?<@?:9>:@95=5DEC;2>=96AF5B=>4=F>CCI@E=E@45C<+=FH>J=2G?FHA9HBDA84?@5F0@@0EHE8;DD;@C6@?H?8@?90FD=IBD&CDF>B?F24?@I=CGF<@:A?FGF>&54GCFB9:;HFFD4@FGIE;CD&C<:B?@1;?8B??DCFGD>9DDD<9ECHEADDBAID8::/?@6=8B@&AGF=@DA?9?BADA<@AJID@>.<8?;5?DGAECBE=EBHF9EF@/<.=D4>FCB4B7@B5C9@?@==>3DD@913?@?AGB@DBDFGGE?>FEIEDDD<9>A@48C@E4ADE@D>5HCBD@GCFBABCFBJE@BCFH:A7E68==?066-898=2@HC=9GI:0?E,F=8EA=>=@E5GCAB8C>3GEEHE@>@;*9>B4DAH@HFI=5IEIDGFECFFD5IJ*CB$6:9F>B6FA?03B;15EAC4A8>2@:@<5D>B@HD@D83?DFB<76<4@3@@*9495/5<444EC=?4<35:DE>?DGG?=DGAEHC6@DDBADBA;C>FE?8DFDGCII@;;C?>>?BE,=FIA@@>>:8IDEI?G@G9H:GE)DA6B9FCE?EC5E?GD9I8?GE>C6>5:@6CB6:4:;EDIGH0DGDC>4HDG>GD$FCAAB:F@BD>B@+136>@DB:;0967:>FCGE/DF6EH4;?;=$3370;CC@K;HE*A=5@EA4E47;=19GAG;<@>@F8@7C:HJH:C=KF=CH2AFCG5D@=B83:>3A01=GKB2GA;I@GHDJBIKG8FD@B@=?C=?>I?F8H?.EA@?@+A?IIDGHEAA<=IBHBEH>E>5GG?9@F>5ABHCBIC;AHKH=HG>B;JA5J?EHIB@AK3KH?5EBFAJEBCIAF@D=9C,;@*C=4C?<3?8=J>BDH@IAKCG?D=IHIB=F@FC;$F6G4<<>8?:DFIEBGB;G?AJJH@DC-E81C=5BDBE>F@AF?CGIHBEGCA=>C+CCEG*ICDC.:3@?:7936B>/6HKEICABEFD?D=F:9B6C?BEJHB0A:9BC>IIDBF19>4FHKKJ>GA?D@FIIB?E7@90;>3D1%?D=EDA@DGB;?@DB9GBD5;==?9HCDK9;HGI3JE0CF&A>:9=-BHF%A?AA@8AHC'EEEFHG:HD@DE@=:?BE:9KHAIAA(;EG?GDBB>I:;=>=17BA>:9CE?D@EG,7?==B:?@G5?G,=FBB1@<:A?:A?E=AHCGF;@HJ;/@=17465%A7DAD0F=D@AEI9J8A?A)<>EDED=>>FF>46?;>IDFA9BD<<)8<@C?2AEDI(DDGDGA;=BDFBE:DGIE>> @rCer/691/25_2220_CCS ATGGGGGCGGTGGCGGAAGTGGGAGCGGGCCTGGAGTCTTGGCCATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCAGCAGAGTTCCCTGGAACCAGAACTTGGACCTCCCCTCTTCTGTCCTCCGTTGAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCAGAGCCCCAGCGCAGAGGCTGCGTTTGAAGGATGACCTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAAGCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGACTAGTCACAATGCAGATATGGGACACAGCAGGACAGGAACGGTTCCAGTCTCTTGGTGTGGCCTTATACAGAGGTGCAGACTGCTGTGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACCCTAGATAGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCGAGATCCTGAAAACTTCCCCTTTGTTGTGTTGGGAAACAAGATTGACCTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATCAACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGAAACGGAGGTGGAGCTGTACAACGAATTCCTGAACCTATCAAACTGGACAAGAATGACCGGCCAAGGCCTCGGCAGAAAGCTGCAGTTGCTGAGGGGGCAGTGAGAGTTGAGCACAGAGTCCTTCACAAACCAAGAACACACGTAGGCCTTCAACACAATTCCCCTCTCCTCCTCTTCCAAACAAAACATACATTGATCTCTCACATCCAGCTGCCAAAGAAAACCCCATCAAACATAGTTACACCCACATGTCACACACACACACACACACACACACACACACACCCCTGACGTAATCAAACTCCAGCCCCTGCCGTGATGGCTCTTGGGGTCTGCCTGCCCACCCACATGAGCCCGCGTGTATGGCAGCAGGACAGGCCAGCGGTGGATGTCATTCTGATATGGAGTTGGCATTGGAAGCTTATTCTTTTTGTCCACTGGAGAGAGAGAGAACTGTTTACAGTTAATCTGTGTCTAATTTTTTTTTAACGGTCTTGTGGTCTTTTTACCTCCCCTTTCCCTCCTCCTTGAAGGCTACCCCTTGGGAAGGCTGGTGCCCCATGCCCCATTACAGGCTCACACCCAGTCTGATCAGGCTGAGTTTTGTATGTATCTATCTGTTAATGCTTGTTACTTTTAACTAATCAGATCTTTTTACAGTATCCATTTATTATGTAATGCTTCTTAGAAAAGAATCTTATAGTACATGTTAATATATGCAACCAATTAAAATGTATAAATTAGTGTAAGAAATTCTTGGATTATGTGTTTAAGTCCTGTAATGCAGGCATGTAAGATGGAGGGTTGAACCCTGTTTGGATTGCAGAGTGTTACTCAGAATTGGGAAATCCAGCTAGCGGCAGTATTCTGTACAGTAGACACAAGAATTATGTACGCCTTTTATCAAAGACTTAAGAGCCAAAAAGCTTTTCATCTCTCCAGGGGGAAAACTGTCTAGTTCCCTTCTGTGTCTAAATTTTCCAAAAGGTTGATTTGCATAATACAGTGGTATGTGCAATGGATAAATTGCCGTTATTTCAAAAATTAAAATTCTCATTTTCTTTCTTTTTTTCCCCCCTGCTCCACACTTCAAAACTCCCCTGTTAGATCAACATCCTACTATGAGAGCGAAAGGAAAACCCTCACAGATCTGTCCTAGTGATTTTTACCTTTGTTCTAGAAGGCGCTCCTTTCAGGGTTGTGGTATCCTTAGGTTAGCGGAGCTTTTTCTCCTTTTCCCCACCCATCTCCCCGATATTGCCCATTATTAATTAACCTGTTTCTTTGGTTGGAACCCTGGCAGTTCTGCTCCCTTCCTAGGATCTGCCCCCGCATTGTAGCTTGCTTAATGGAGCACTTCTCCTTTTTCCAAAGGTCTACATTCTAGGGTGTGGGCTGAGTTCTTCTGTAAAGAGATGAACGCAATGCCAATAAAATTGAACAAGAAC + KF$KKKKI;HJ,KC;KBKKK6KKGJJ8KKFKKEKGHHF)KAKKKGIKK:JDKIIKJJFI=AKKFJKK?JKKEJHKKJIJBKJJIJ?K4KJHKKFJJ@K?KJJ=KGK@K;JJGJ9IH,KKIEFBEBEAKBGHK6KK>KHKKKJEKGGKGIGAJDHJKKJFHJKJKKBJI>KGEKKKKK@KJJJKKKGJ?KKHEJGJKIK?J=KKIKKJG=HACKAKBJJIJIIJJIJA:E5JIJKIKDEJK=KKJICKJGKKDKKKF;GIAIEI@JEBHJJKJKKJKHHJIEIIJ$GIKF;KJIHFFJKBI>J4KJKKKJJGJKK9HKIJIGIJKK5IKIKKKJ?KKFKGJHJF%AEJKKICEJAG)IKGJFJ5KKJ7JGJBHJ8IJKHKHJJ>JJJJHFID;BIKGKFFJI*IKGI:IGEFIJ:F0HJHICFJI@IIIJ0JKJHJAKIG9KKKKJIF3HIJKFHFKGIKK6K.HFDD=GHKB?J9KKG?@JBIIJGKIG=KGKIKHJKC2KJJ=K@KHKKIKIK:JGKKJK:KAEKHCKEHKKCHDGKEIGIKCIJH@KJJ$KHJ2KHK6IKJ7KKEIFKAIGKKGKJKIDC(JEJ@KEK7EFI@KKFF(IJIJAJJEJ:IJIC8:-FFGKJJKEGFB@J?KGEFKJJJJIKI8KCKKJFAKKEJJKJCHI;F@EIKICG>D>GJEKJDKGKCK4KKHFEJ>GECCGD=GJK:IHI9FKKIJHKFJ/KJJGJKJJKI;EJ3IIJIJK31'IHD5GJJ.KKKJHJ1GKEEEGBGJEIE%IEBJHCJKG@GA@>EEE;90BFC=;=CEF8@FF>AECI@G5FKKCIJKJJHJKJB@4HKK7JJIIKKH>G&KIJHBGF@GKAKHHJID)DJGFE@?JHBHFIJKIC>HEKI7KKKKDKKK?KKJKHJIJJ8HE(JKKJJCIIDKKKKD94IE@/=H,DF8H;HFDBDHH3IEK:?9)DCAAKHHKJJ2KKK8KIJGKFJKKGII.KKJHADFKHKHBJJ=AKKHKJHIGKKJJK%G=9IJK'KKKJGKHH.KKKKKHKGHKKJDKKKJBKIKI:EEKIKHKKIKKKIK>KKKGIKKGJKKKKHJFKHHKJJJIIK0JKKKGJKFJKK4KHKBJIKJKKKJG5JCKKKKDKGIKKJHKJKECK6KKKKGKJKIIKJKJ3KJKKHJIK>KKJ.KKKKEKKKJBK*KKKKKBKIKJ:KKKKKKHKJK?K>KIJEF/JGJEKKIKAJJKJKCKKIAKKKIIIJGJKK?IGGKCKJG@KKIKHJ@KKFKKJCEKKKIKJKKJKFJ8D@GEKIKIECH?KKJIHKKHKJJJIHKKJKKJKIJKKHKHKJEKHKIK8KIJKKKIJ;BFJKIHHKK @rCer/692/24_1732_CCS ATGGGACCGGAAGCGCAGGGGGATGGGAGGCGGTGACGCGATTCTGTCCGCGTTGGAGGGCCGGGCCGCTGCTGGAGTCGCCGCGGCCGCCGCGTGACGTGGCACAGCCAGATCCTAAAGGCTAGAGCCGGAGCTGCCGCGCCAGTCGCCTAGCAGGTCCTCTACCGGCTTATTCTGTGCCGGAGCTTCATCAGCACAGCGGCCAGCGAGACGGGCCTGCCTCCCCTTTCTTCCTCCGCTCTTTCTCTTCCCTCTCTTTAGTTTGCCTGGGAGCTTGAAAGGAGAAAGCACGGGGTCGCCCAACCCCTTCTGCTTCTGCCCATCACAAGTGCCACTACCGCCATGGGCCTCACTATCTCCTCCTCTCTCCCGACTATTTGGCAAGAAGCAGATGCGCATTTTGATGTTGGATTGGATGCTGCTGCAAGACAACCATTCTGTATAAACTGAAGTTAGGGGAGATAGTCACCACCATTCCTACTATTGGTTTTAACGTGGAAACAGTAGAATATAGAACATTTGTTTCACAGTATGGGATGTTGGTGGTCAAGATAGAATTAGGCCTCTCTGGAAGCATTACTTCCAGAATACCAGGGACTTATTTTTGTGGTAGACAGCAATGATCGTGAAAGAATTCAGGAAGTAGCAGATGAGCTGCAGAAAATGCTTCTGGTAGATGAGTTGAGAGATGCAGTGCTACTGCTTTTTGCAAACAAACAAGATTTGCCAAATGCTATGGCCATCAGTGAAATGACAGATAAACTAGGGCTTCAGTCTCTTCGTAACAGAACATGGTATGTTCAAGCCACTTGTGCAACACAAGGAACTGTCTGTAGAAGGACTTGACTGGCTGTCAAATGAGCTTTCAAAACGTTAAATGAAACTGGATATCTAACCAAGGACATGTTTGATAAAATTGGCCTAGGCTTGTTACAACAAAATTAGTTTGTATCTTGGTTATTAAACAGTATCTGGGACTCGTTTGGGCAGAATATTATTTTGTTGCCAATTATTGTTTACCAAGTATAATGTTGCTATTTAGCAATTGTGCTTGGTTTTAAGAAATTCTCCTTGGGAAAAAGTATCCTTTTAAATTTTACTTCCCATAAGTGTAAATGCCTGGACATAGCTATTGTGAAACCTTTAAATAAATTGGTTTGAGTGCTTTTTAAGCCCCAGATAAATAATGTTTTAAAGTTATCCCCTTGCTACTTTACTGATACCTTTATCATTCCTGAGACAGTCTGCTATTTAAAATGTAGCATTCCATTTGTATTTATTTCTCTCTCTTGCCAAAAAGATTTTCTAATACTGCTTGTACCAGCCACAGAAAGATCCAAAACACTACTCAGCTCTCTTGCACTGAGGAAATTTTTTCCCCTACATTGACTCCTGGCCTACATCAGCTAAACTTATACCTTGTGGGGTTTGGATTTGATAGCTAATTAGTTCTGTGCTGGCTGCAAAGAATTGAGATTTAGATGGTTTTAAATACTCAGCAGATTGTCTTCCTTTATATGTGTCTTTTTATGTTGCATGTTGCTTTTGTTATCAGCCTGATTTTTTGCTCAGTATATGAGAGTTCTGCTGATGTTTTGTTTATTGAGCAGACATACCTTCATTAAGAGTTTTTGGAAACTCATCAAATTGATGAATACATTTTCTGCATAACCCATTTGGAATTATTCCTAATAAAATGATAAAATAC + 34'75,%6)5/;772:4(24:1.:%;924?>3;:>72;93<82>=;<'85=3&:=/7/=:1==9<;136714=;<&68;59088*5344718:9:1?25=5:6:8509;920>>/=6896966?.9:=9877=<=86?47205*8<4:=8-<=9;759*):99)80;*;72:9&78747<=9=>7>3<;>>>;749(<8-:8:9>24>>>7?=98?,926?//.=3====44>8?=8=;8$;<.5);<;2>78=<>><%8:)980:982;>;>8='<;<4<=->5$:%4985=27=;1:988)<86;9986;*24:?;7,1,:82?>=(<;'4.<>997;681=<%<-0$16*752;>01)8:0?<=?;>?89>>;6<>767&6:;==:#/9287.;9=:>>:;773%6)=694(8(757=:9=994,989.9+<=2<;'==4:5417>><95=45::1:8<;>3(6)=5=%;664;3<63><;=98947;>5#88<=:.76;7<<<4<<=*2/&9;;<8(;*8<:?9;9=>>78333+8/5?1>677:7292=;<;483=/<'47;,9/)%/3-=<<,2;.(9:<;9=9?4;=>=;9=)86=:2=65=2>=60:$2590;);843<=8;989;-/>=98:,;=;7;9)4815=63627:80,=76<9==9=>::98=88:889%8558:9/><5)<86/940)8=94;)<718=*=>1?7?>>=94;9)7:60.59><;:>?9052=<6-=;1745%-+878629:>>3:98/6===:=+<;0;;1?>>>?==::/85333=7=8;:6$594167+*<7?:=5?B=8=.<<=>>59<@?=;=@5=@728@>8A->0B??A'@@4;0=:<899.B@68=&:>?/C>EAE@3?DB>B?7D@D>?82ACD>209F=%=<<;,AC6EDGBC>+=:.>?17.?;GEA6B*@A6@E0B2EB@;C+A9D6@A6)DC9E=*=:>=@B$@>>5DB(AC??:4C';?,A4D<363&<-;8CDCF>G85<4@E,@?FG&A@?.DF.E?/GE7)A?D3@?=1BA95CA@%B@>?D<>@AA3EB;@@DBCA?C.C>5=A>?DBGBCE???:FBE@.>@BG)BB@A=B6GDGEA:@:>:891?BB=D@?*FEABDGDC4D4EB0ECED7$=9<8?DFCGCGD@=FB9G(C=3;BFFAFBD*DBD.@;;;;G//#43:@:B(DD?,A:D;7>8A=>0?>><5$,=:(..C@AA;CD&>>:?CA:G@B5BFCCAC@?EF@;FFF;0BADFFC?BDBFB18=<=;>><5D:@EE;5/?>'@@BB0DFC?DEA7@A?4@+CBCB<<*AC8A;D@D-?EBDCB8GEG=E?B:2DC:G/E=C?*C6FACEE(@??9D@?8EE@4A6 @rCer/693/2644_53_CCS ATGGGGCCCGCCTCGGTAGCTGCCTGAAGTAGTGCAGGTCTGCCGCGAGTTGCAGGTCATGTCCCTGGCCGCTCGACTGTGGCGCTTTCTGCATTGCGACGTGGAGCCGCCCCGGGGCCTCGGCTCCCTGCGGGACTTCGGCAGCCGTGGCATTGCGGCCGCTGTCGATTCCGTGGCTTCGAGGTAATGGGAAACCCAGGAACTTTCAAAAGAGGCCTTTTACTCTCAGCTTTGTCTTACTGGGGTTTTGAAACTTACCAGGTTATCTCTCAGGCTGCTGTGGTTCATGCCGCAGCCAAAGTTGAAGAAATACTTGAACAAGCAGACTACCTGTATGAAAGCGGAGAAACAGAAAACTTTATCAGTTGCTACCCAATACAAGGAAAGCGAAGATGCAGAGTTACTGTGGCGTTTGGCACGGGCATCACGTGATGTTGCTCAGCTTAGCAGAACCTCAGAAGAGGAGAAAAGCTATTGGTGTATGAAGCCCTAGAGTATGCAAAAAGAGCACTGCAGAAGAATGAATCACATTTTGCAGCTCATAAGTGGTATGCAATCTGCCTTAGTGATGTTGGGATTATGAAGGCATCAAGGCTAAAATGCAAATGCGTATATTATCAAGGAGCATTTTGAGAAAGCAATTGAACTGAACCCTAAAGATGCGACTTCAATTCACCTTATGGGTATTTGGTGCTATACATTTGCTGAAATGCCTTGGTATCAAAGAAGAATTGCTGAAATGCTGTTTGCAACTCCTCCGAGTTCCACCTATGAGAAGGCCTTAGGCTACTTTCACAGGGCAGAACAAGTGGATCCAAACTTCTACAGCAAAAACTTACTTCTTTTAGGAAAGACATACTTGAAACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACTATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGTTGCTTACAAGTTTCAGTGAGAAGAACTGAGAACTTTTCAGAGACGATGTGTGAAACAGCTAATAAACATTGCCTTTTCATTTAATTAAAAATATATGAACTATAACTGTTCTACGGCTTTTAAAATGTTGTGACCATTTAACAGTGTAAATATAAAAATTCTAGGCTTCTTCACAAATAATAAAGTAAAATAAATAATTGCCGTAAGAGTGGTAGAAATAAATCTCCATGGCTCCGGCAAAGATTATTTTGCATCCTGGATACCAGCAATGCAAAATGGTATGAGATTTCTAAGGATTGATCACATTGGGATGGGAGATCAAGCAAAGAAAGCTTTGTAGAGGAGGGAAGTGGATCCATAGGGGATATACAGGGGGATGGATTTTCAAGTTGGATTGATTCTAAGTTGAGATCTTTGCAGAGAAGGTGTGGTGAAAGAGGTTAGGATTTTGTGGTTTCCTGACATAAAGTAGTTAAATGATGTATCTTGGAGCTAACCTGTATAAGGAAAGAATTAAGTCAGGAGACGACTAAAAATTGAGTGGTTTCCTTTTTTATTTTTATTTTTTTGAGACAGAGTCTCACTCGGTCATCCAGGCTGGCGTGCAGTGGCACAATCTTGGCCCACTGCAGCCTCCGCCTCCCTGGTTCAAGTGATTCTCCTGCCTTAACCTCCTGAGTGGCTGGGATTACAGGGTTGTACCACCACACCCGGCTTTTATATTTTTGGTAGAGATGGGGTTTTGCAGGTTGGCTAGGCTGGTCTCAAACTCCTGGCCCCAAGTGATCTGCCCACCTCGGCCTCCCAAAGTGTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAGTTTCCTCTAAATGTGGTGTATAGTCTCATGGTAGACTGAATTTATCAGACACAAAGCTCTATGCCCTAATGGAATGGAAGGAACACAAAACTTAAGAGTGAAATGGAATACAAGATGTTTTTAATAGGCAGGACTATGCTACTCACTTGAGGCTGGAGTGCCACCACTGCAAAATCTTTTTAGTTTGTAAAAAGGAATATCATCTTGAATCCACTTGGATAAAGAGAGACTGTGTGTAGGTGGATTTTCCCAAAGGATTTGGAAATTGTAATGTTACAATGAACTGTATGGATATGCTTATCAATGTACATTTCAAACAAAAAGGAAGACCGAAAGTAGTGATCTTTGTACACCCATCTCAGATTCAACGATTCTGCTATATAGGTTGTGTATCTCTTATCTGAAATACTTGTGACTAGAAGCAGCATTTTGGATTTGGGATTTTTTTCAAATTTTGGAATATTCCATACACACAATAGACATCTTGGAGATGGATCCAAGTCTAAACACAAAATTCACTTGTTTCATATATACCTTATGCACATAGCCTGAAGGTAACTTTATATAATATTTTAAAAATAATTTTTGTGCATTGAGACAAAGTTTGCATACATTGAACCATCAGAAAGCAAAAGTGTCATCTCAGCCACTCATGTGGTCAATTTGTGGTTTGATGTCACCATCATTCCTGACTGAATTTATATGCTACCAATAAGCAGTTACTATACTTATTCATGCATAACTACTTAACAGTAAAAACAATGACATAATTCGCATAG + <=@>A--6(292317-:=;:=B976:=8<795:;=;<'4>365,:62==866/A:?<@;:@B@@&AD0E2DAA5=;:848?*9:.>D5A>@$53&@9>3BAD4/6/@58A?D-AFC.;&4=>'*:D@03??CB+AED4AA%81B)CGH5B355;1DDB.?G;GE?4CG+GJDBG5J:@>57GFE>-6<8-F@DCD38>::4+;ECCF/A?DFCED<:F5E>A>9:>?:8;3=:=>=897:>9B:974%@F6;B9CC17B57;,?CB6?>@D5@>.8>2:?A?;;<;C>*:FG?68BA(@?A>C>+9@<.4?E=;:;F;7#*070GE78,@GAD=D?CBC9=?8?@=;8C=??>@*E><;DDB,*=@A7CB:@?=96<6>2ADF=:C5FDDE?BC828E:<@>BB$D>?;<@@E:BE13@1?;>0@;-C?BEB%=FE;>@5DB>;==C5BAC<95(8:A@?<:A$=>?><96C2F=:6@C:9BCCCC@;8%A?BA3;7758.;39=5?AG0E=;8@9BEG7@9<@@3:BF>F9BD:=8AB5AB?;7A0@=>?AD@?.:DF1=8@BA6?9<<9<8@:?<=><<1@;7/B?BED.=4>41C=,4F=<=5:<>8;B2B65>9:;9@1@/DE?A7>A>BB=4?A=89B)>@=?6=?;?B@66?:5?D/7CA>B9<8976CAA(:C?EA?,<=?C0=E?EC<;B:46E==6DDD3EC;5:CE2ADCCA*BEG9@=A<7:?-5=C52>;36ADA1>C7A7C:AC>?>82=<9+3<6264=;6->70<9AA.C@DCD:@EB;A1AB;?;;CC3EA@0)=@2:49D;B@@&7D;39>69?3=>;9-C/;3321@478=6=C=@/BB@;A@*BD@4@372:C:B@B=?;AA6>9*.08;4)66;;<=E0@C=-=BA037?/;763A7>8A%B2C?';90E(:EE?4:A>BBE?<=E6<=:@GII@EFF97?EH>9BJ=2>94F>A>@&BFE5<=BA$@7:G<:E?DE;CI:D@DF:GHAD<<-@EA2D8@DG89@@<6CDD?=.B>GA>>=>A>8%;B;5B;??2=F?A;9@;=F?FHHGHGIC5G;EBGFGGH@8EHEFA==2A;BF?@5EDJE?B?G9E5FB=,<@?%@7A;CG52'3IF?AHDG8EEGHF<@B1D:FBABEEEG>G=<EDGA>76B=BFEDAIH,B9C9ADD:?D1E:CDCFF0,>%HAFCAA6=<9/.@>>>?=5>:?@>@AD:8?IEHG=?==CDF,2;?B&:>E@?A>6>B>@C>BAD.CG;G6?A>FFC7<,*/98@IF;@5@8A(CD/AE=5FE@ABDG2DCACGEHF@A=D7@F0;?*;?7BG4D;@HFC2==8?>?F3G;F?DCIC:B@B.AE>%:&-:.84@0B0A;9,=?B@@>7<>@(4/<@>?>7;=<;)>10B@D9@1:2=-@D,??E@@A'<@:?;><%75:4<37'2C273;9-9@3E6C?C@(,-B:7?DB=>C>@C@CA8>7@>B;;9?*D@CDC;8=A4C>;@B@920:/C>>(1G:D:@<@,DFG=EGBE6A;EA0A>;BACCA2=$=AF7CCD09?>=-=<D?EA@0D@?@84*$,>=+BBCB@8%@?<5;6=>46@>1893:<::@:<>===>@(2<,33=:@ABD>::.;;AB>A@E4+@?%5B9975:B,C>A?5:.E7B)8?D;@>:;?9F030>>C1<8A:#?B:;;948%6A;*;@ACD-?2B;A@FDBE@=B9BCAE99@B<6A::?09C/=8<9;8)&4+-1:-9<;A+<==4=D9(=.0B0:761;7,2D57A99?=?486@<<7<&D@1=>CC@=?$7<<(F@@0?:A:B9$(C:.2.><>ABA76%4/7:?AECB;>ED2=$<6B>>:?7><>707>DCEC=A=ED=D0@?D<<;9;<094=A05?C:;?CD0+/..4:/2,0:9)395:&8B/;AD94B<6A@?8+2=0BD====?-A36E<@B<;B?5>93D:><6:=D<@BB/D?DBBE>@:@A8?=42=<=7>4B=ABB6BB/4=B0>A.>>BD>;?E;'8>67&8-9B:=D@F898$B?20:47504<,3B19=*4E:;7;;@<.=/?=499>:?ACE3@2=AD79EDD*DB7<>C93;?:C4@=29:B? @rCer/698/1761_59_CCS ATGGGAGCGCAGAGCGGTTTGGTCGTTCGTTGGGCTTGTGTCCGTTCTTAGCTCGGCGATTGCGGCTGTTCCTCGGGCAGCGGAAGCGGCGCGGCGGTCGGAGAAGTGGCTTAAAACTTCGGCGTTGGGTGAAAGAAAATGGCCCGAACCAAGCAGACTGCTCGTAAATCCACCGGTGGGAAAGCGCCCCGCAAACAGCTGGCCACAAAAGCCGCCAGGAAAAGCGCTCCCTCTACCGGCGGGGTGAAGAAGCCTCATCGTTACAGGCCCGGGACCGTGGCGCTTCGAGAGATTCGCCGTTATCAGAAGTCGACCGAGCTGCTCATTCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGCTCAGGATTTCAAAACCGACCTGAGGTTTCAGAGCGCGGCCATTGGTGCGCTGCAGGAGGCTAGTGAAGCATACCTGGTGGGTCTGTTCGAAGATACTAATCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATGCCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGCTTAAGTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAATTGTTTATAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGACCTCAGTGATGTGAGCACTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATATTTCTTGCTTCTCATGATGCATGTTTCTGTATGTTAATGACTTGTTGGGTAGCTATTAAGGTACTAGAATTGATAAATGTGTACAGGGTCCTTTTGCAATAAAACTGGTTATGACTTGATCCAAGTGTTTAACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGAATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGTAACTTACAGTTTCCTTTAAAAAAAAAAAAAAAAAAAAGTAAACCTGGCAGCTATAGAATACACTATGTGCATTTATAATAGCTATTTTATATATTGTAGTGTCAACATTTTTAAATTAAATGTTTTACATTCACAAGTGGTGGGGAGTCTTGTCATTAAGGTGTGTGTAATTTAGAGTCCAGTTGGTTTTCTTCTGACTGCACTTGTTCTCATAGTAGTAAAATGCTATGCGCATTTATACCTTGCATAAGTCCTCATTCTACCACATGTTATCTAACCCTCTAGCTGATAATGCAAACACTAACTGGGGGATTTTATTTATAAGGGCTCTAGAAAAAAATACAAGTTATTCACACCAGCATCATCTATTAACTAATATTCTGAACTAGTTAGTGCAGCTTTTCATTGTGTTGTGTGGTTGGTCTCATAACTAGGTTGAGTTTTTCTCCTCTGCTAAGAGGAAACAGTACCGAAGTTCTTTTTCTTGTGGCATTTGTATTATAAAAACTTGCTGTGGGGGAGGAGCATAAAGCTCCAGCCCACTGAACCTCTGCCAATTAAGATGGTGTTGGGTTAGGTTACATCTGGTTACTGTCCTGGGAAAATCATTTTTATAGAGATGGCCTTCCAAGTGGTTTTAAAATTTATCTTATTGAAGTTTTTAGGTCAATTATGTATGTTGACTAAATTTACAAATAAACTTGTTT + HDIDFIKFIKIHFKGKHKK?KJGKKGIKIE)FK5:IADF:HKCAE;BKHGKIIJJ@JKJJIAAH7EDJKKKICJIDA@EAFGJKBBHJGJJIKHC@9HKJ;IKFGJEC?CF(@GI5KKIHKDJJKAKK?FEIJ:GKEJIJKIKJDJJIJCKHIB@DHKJJ5:KIEJEBAFFJHJHHKHJI;GKCJJFJ4FJ6KJ8ID=>HG:JKDK.IJFJJJHKD@EHKJHAJIIEJKHICKKKKKKEFDCGJ4F0CKHKHJJJJJ=ACJKJKKKIHKJJKKI9JIJKKJJHGKFJEKI@J?>HGKKGBG0AHH=HDIJKG>JKKIDAGGJKHKK9JHJFIKBIHHCJ8GKKJIKJ@IEHKFIG5E6BG4GKGKKDKJDKJIEKKIAJ8IKJIJIJ@HKFJKJJIIFICAGFB9?IJAGGHHDF'F8@=F9?:GIFEA?D@EFD>B>@D4BJ9EFC4GDGABJI@07:JEJ?HGHJFJIJ9JIKJKF8?IKEKFDDJJJB?D:DHFEFJKKJKKJJIHKI=HJJIK?JKJKK?JK%DEC;ACAG?KIJKDC=JK>G6IEIJ@HIJGKFKK>JGGKKK4KGKK?DKKKKKKKJKKJGHJJJKJ#GEKI)HE3KIKIJGJJFFEK=JJKD@JDJBIIIIIH'7IB=FHJD8IKKE5@FJGJFDKBCJGJJGK>IJGJKKGEK7HFKKDJJKKK0BGIJJIK>KDI@KHHKIF8BJHJKAHKJJK@KCJCJIE:GIAKIJK6FKCKHKJKJJ*K=JKG0KKHHIJJFI6?DJJ:GI6KJCJFA0;KJIHJKEJKJKKEJJKKEKHKIIEKEK>JFHIJHJHDBKDCF@HJJ?JKEGKFKJ=EGH4=IIIHDKFKKGKJHKGJGJJFFHIGGK3KKFKHK;KIIKCF?;4FEG,KKK'4J4KKKJKJK9CICIKKKK0FGDGIKEKCHJIKJIJKIKJJKKKEKKAJJKK:GJI>JKKIKKC @rCer/701/2039_54_CCS TTCACGAAGACCTCCCAGAGGCACGGATCCAAGTACTGGCCACAGCAAGTACCATGACCATGCAGGCATGCTTCCTCCAAGCACAGAGACACGGCATCCTTGACTCCATTGGCGCTTCTTTGCGGTGACAGGGTGTGCCAAGCGGGGCTCTGGCAAGACTCACACCACGCGCAAGAACTGCTCACTACGGCTCCTGCCCAGAAGTCACACGCCGGACTCAAGATGAAAACCCGGTAGTCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGCAGAAACCAGGATTGGCTACGAGCAGAGCGTCCGACTATAAATCGGCTCACAAGGATTCAGGAGTCGATCCCAGGCACGCTTTCCAGAATTTTAAGCTGGAGGAAGATAGTCGTCCGGATCACCATGGCTAGACGCTGAAAACCACCTAGTCCGGAATCCTGTCTCAGCTTCTTAATATAACTGCTTAAAACTTTAATCCATTTGCCCCATTACCTATTAGAGCAGATGACTCTCCCTAATGCCTGTGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCACCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCAGACGCTCGTGGTCTTCAGGGGCCAGGTGCACAGACGTCCTCCACGTTCACCCTCACCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTGCTGGCACTGCGATGGAGCACACAGCTGCAGAGACAGAGGACGTGGGTGCAGAGAGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTCTGTCTTCTCTCACTCTAAAGTAGACTTCATTTTTCTAACAGGATTAGACAGTCAAGGAGTGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGCTGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGTCGTGGCTGCCACACACCCAATTAGCTGAATTCGGTGTGCAGAGGAGAAAAGGAGGCAAATGTGGCTGGCAATGGCCTCACACAGGCAACAGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGTAGGAGTCCTTGGACAGCCTCGCAGCCGCGCCAGTCACCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGCCAGCACTAACCTCCTGAGAAATAACCGGCTCATCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGCTGAGCGGATGGCCGTGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATTCCTTTTGCTCCTCCCTCCTAACTACTGACCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCAAAGAGCCCACGCTGGCATCACCCTCCCGAGGACGAGATGAGGATAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGTTACAAAGAACAAAACTCCAGACACAAACCCCAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGTGAGGTCGCTCTGCCATCCATACGTGCGCACCCAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTAATG + 3*(-&*.$%#-)(/.&,,/4-*1-1*.24.3../+%.+%40457635'&512%62'29048-%0948:6,36+-$,7&81)'4903649019?*4(+?1>2A3%,?,3@5@-0;/?9B@?-..=4:8578BA,A98;6$569D@?A'8:<@C1>>0#62@8>987(?994(@E@DE46>@2=31%?@DCD75;G47>-@%ABD2BABE;>:3;49@*DEDCEC:@21<>;&<-3;89:'6C6@8/188<7>5AA=;;&DDA&?@@?CE;9>@@C@A@.=69=,@):=+@<4?-<@02<$+.:;=:$,'96;4;8=@C2@EE>52?A%@>C6:C@2:A*E;>B0>$;3?=D<9A$'E,=F',3>>=?@+C1@*@7A=A+746*6<*14/++6+5;&?6%7;/;'2D=<@):CD9@?>4??,?;AFFD3;='9?1:.>.6@-F:A>=B2=<;%A,5DB,8;6&;(4?$;CC+?>?B&(A9AE*=,;66:3859:@9-6(/;=,@$1@(;EA,?;4&=.C4AC==9A@EC'?4>C'5GAG07B8?C:,=%#)F@F7J>BI3IJ-B;F:G2E&<8DFBJE:@,IB@DGI:>EIHG'D>@ED>/DC@ECEGC?A,IHIIAHF?#2=8EFJ:G3@?87DI-J1C,=8:#CHE9<2>4@B>&ADIGADD0BAB)@HI>D=AAF'F5@?-;B<2<<78D9<@618(;:1B7<>=D5=6>B2E6;$AFHC./GFH3C5?-1<57.?8=:=845@.GA-62*>D%32%%695<6?.?@>05@8-4=&94;>=7&)-:::;A'%9<0D,3=G;C)CB(4EFFEGGGGAA@@B?#?<64'<57?;;::$5/6;A%?=A?FCF+3;JJIA*$?D(:E@$EF(D0&>1562F/G61+*+9E?D@=<;IEBFDD&5;@DB@%C4HD9(47C-=C9;D(7>F$A+5B:=E/H9:>0>>'H&/DFA@D%@EG<9,%/.D?GCJ*A.IK09*D2HD@?$@,8>J8I)6,>=EK30I,I%*@9D-GCFGE:>&?EADDA9B3:.@>D)E9A@1&/H?DGGD@)=0H>9JJ9FGDD.8C?9:D6KFB;4;?6?F>@@AD/15+IH,E?BIJCD2JEIEE-EKH@JD2H@E5;3-;H4G6:F+A@?2C(51G.H7I7&:(>F7BB.>B'BJK/FHH7=IG2AIHG>HA7>J,H>JB1CB==DFF/=;@C1%J:EFE8H%E96A;B?HD:HIE,F=FC:J?6H39C'D-@FJ*K)E.8H>;DE.GF;<2IJH(>324GI(;80I3CKI2-<'0B+$6=DFEAB06@-JKK8JFFDA%?1@;.==G.8E?JF?B7I,;2'7D9>@FJH%<;FE5J6JFC:C>=%4IJ4JJK2H26#%@HHJH&+C?ECC:(7:A6A=D@)ACJ3HGHHA@K?@G7D5=I'@8FA?B0G)8@=I=EGII*6;@/A@C'3A,D-I9/-8;HG?79H:J:AIGIHCFI;D?FC-3=?@F47F6A1FHEK3HK*4IE<.68?%BHIFCCEC(D@6&%6CDCB7AC>>(1B0/?DDDA0DBIH:DIE>>+68B:+:$2ABGFFG-=?G6D@?1F?/+:-5:8'B&991?9*04=F>ED9C<2;8I3@GIC4;>3JFDF1;B=H*?D<11;)/CC%//AB @rCer/702/25_2394_CCS ATGGGGCGGCCCCTCCTCGCAGTGGTTTCTCCTGCAGCTCCCTGGGCTCCGCGGCCAGTAGTGCAGCCCGCGGAGCCGCGGCTTCGCCCCTCTCCTCTGGGTGGCCCAGTGCGCGGGCTGACACTCATTCAACCGGGGAGGTGAGGCGAGTGGAGGCTGGTGCGGAACTTGCCGCCGCCCCCAGCAGCGCCGGCCGGCTAAGCCCAGGTCCGGGCAGACAAAAGAGGCCGCCCGCGTAGGAAGGCACGGCCGGCGGCGGCGGAGCGCAGTGATGGCTGGGCGAGGGGGCCGCGCGCTGCTGGCTCTGTGCGGGCATTGGCTGCCTGCGGGTGGCTCCTGGGCGCCGAAGCCCAGGAGCCCGGGGCTCCCGCGGCCGGCATGAGGCGGCGCCGGCGGCTGCAGCAGGAGGACGGCATCTCCTTCGAGTACCACCGCTACCCCGAGCTGCGCGAGGCGCTCGTGTCCGTGTGGCTGCAGTGCACCGCCATCAGCAGGATTTACACGGTGGGGCGCAGCTTCGAGGGCCGGGAGCTCCTGGTCATCGAGCTATCCGACAACCCTGGCGTCCATGAGCCTGGTGAGCCTGAATTTAATACATTGGGAATATGCATGGAATGAGGCTGTTGGACGGGAACTGCTCATTTTCTTGGCACAGTACCTATGCAATGAATACCAGAAGGGGAACGAGACAATTGTCAACCTGATCCACAGTACCCGCATTCATATCATGCCTTCCCTGAACCAGATGGCTTTGAGAAGGCAGCGTCTCAGCCTGGTGAACTCAAAGACTGGTTTGTGGGTCGAAGCAATGCCCAGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTCTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACACGGAGTGGTAGTGCTCATGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGCATACTCTTCTTTCAACCCAGCCATGTCTAACCCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAATGGTGGTGCTTGGTACAGTGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTCAAAGGATTTGTCCGAGATCTTCAAGGTACCCAATTGCCAATGCCACCATCTCCGTGGAAGGAATAGACACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATGCTTATACCTGGAAACTATAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGTTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAAGAGAAGGAAGAATTGATGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGCTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTAGATTTTGTGCAGTTAATACTTAACATGATTTATTTTTTAATCATTTAAATATTAATCAACATTACTTAAAATAAATAGCCTCTTAGGTAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTCATTTTCCTACCTATATTACACAAAAATATAGAAAAGATTTAAGTAATTTTGCCACCCTAGGCTTCAATGCAATATTCCGGTATTATTTACAATGCAGAACTTTTTGGTAATCTAGCTTTTAAAATTAGTGAAGTTCTTTACTGTAACTGGTGACAATGTCACATAATGGATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGGCTTAAACAATTCAGTATAAATTGTCGTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTAAATGTTTACAAAGAGGTTTTATGAAGGAATAAAATTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATTTAGTCCGTTAACACCACTTAAAGTTTAGGGTTTTCTCTTGGTTGTGGAGTGGCCCAGAAATGCATTCTGAATGAATAAAG 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rCer/703/0_3115_CCS GTTGGCATGCACAGCATGTAGATATAATGTCGTAGTGTAGATATTAGCAGAAGACACTGAGTTCGAACTCCGCGCTGTTGGCAAGGTGATTTGGAGAGACAATATTATGAGAGAGAGAGGCTGGGAGGATGTATGTGCATGCAGATGAAAGGAACACGCATTGCGCGAGAAGCGCGCTTGACCAGGGTAGCAAGGGCCGCCAGCTAACTCATTTCAGGGCTGAACATGACGGCAGCAGCCTTGAGGGGATGGAGTTATCGAGAGTTAGCGCAGCCGTGCGGTTTAACTGGCGACCACGATCATGAGGACACTCTGCTTCACACAGTAACTCTTCTTTCCAGTTACCCGTAGGTGCGGTGCGACTGAGGTCGGCCTTTCATGACTCCCTGAGAGGCGGAAAAATAGATGAGGTGACTGCGCGAGCCTGCACATTAACTGCGGCGCTAACAACCCTGCAGCAGGGCTCTCTCTCCGATTCGGAGTGTGCGTCAGTATGGCTTTCCCACAAGGAGATCCGTCCTCCATACACGGCTACATGTGGTGTCTCGCTGATCCTCTTGCGAGAGTCCAGTTACAGAAGTAGACTTGAATAAGTCTCTTGAGACACGTGAACCACAGGCAGGACATATGGGGAGCGAAGGCTGTCGCTAGTAGGAGTTTAGCTTAAGATGAGAGAGGAGGACGGAGTGGCGGCCTTATTGCTAGCGTTTATACTCCTTGTAACTAGCCTTGAGCTAGAGTGGGGAATCCCCATTGAGGAAGAGCACTTGAGAGAGAGAGCTTAGTCGGGTATCAGTCGGACGGGCACAACGGTGATTGGTCCTGGCACCGGTACACGGAAGCAAGTGACTGTTCCTGAAGGTGAGCATCTTCATATATCGGAGATCGTATAGATGCGCTCAATGTGTTATCCTCGAGTTCTAGAGACGAAACAAGCAACAAAACATAGAGAAGAAAGGTATAACACAGAAGTAAGGAAAAAAAATAAAGTAAAAAAAAAAAAAAAAAGAGCAACAATTTGCCTTCCAGCTGAAGAAAAGATACCAGGCTCAATCCTCGTGGACATGCAGGGTATGATCACACACCATGCTTAGAGACTTGCTATGATTATCTACTTCACGTATCATGCAAGTAGATATAGAGAGACGCTAATGATATATGTCAAGGAGGACATCACTAATGGCAGCTGTGATGTGTTAGACGAGGATTTACACATACATTGGAGACTTCTCTGCGGTCTTAGTTCTACTTCCGTCCCCTACCTTGAGCCGTTCGTGCGGTACTCTAGAGGGAAGGAGGCTTATACTCTGGAAAAGCAACTTGCTGGAGGGGAAAAGGAAGTTCCTCTCCGGTATGCTAACATCACGTATACAAAAGCTTATGGTGTGTATTTTAAAAATCAAGCAAAACTGTTCCAGAATGTAAAATCTAAACCATCGCTTTTCCCCCTCCTCGGATGAATAGTGTTTCTTCAGGACAGTTTTATTTTAAGGAATTCTAGATCCAAGGTTAAACACGCAAATCATGTAAAAGAACTGGTAACTATTATCAGTATCTCCTTTTGGATCCATCTTAAATGGAAAGGAGATGGGAAAAACTTTTAAAGAGAAGGAAAGAAAATGAAGTTTTTTATTGACTAGAGAAAATATCAGAAGAGACTCTCTTAATTTTAACCTAGATGTATCACACAAATTGGAGAAACAAACATTATCCCTTGACCATGTAAGATTTACACCACATTATGTACGGCATGTAACTTCATAAAAACATGTCAGATATCAGAAAGAGCTGATCTGAACTGCTGATATCTTATAGGATAACAGTAATCAGATATACAAGTGGCTACCGTTGACAAGACCTGGCTAGGGTGAGTTCTGCTTTTCTTTTAATATAGAATTATATATTGTTGCGTAAAATTTAGCTTTTGGCTTTTACGTTGCTACTCTTGATTATAAGAAAATTTGTAGGTTAATCGTCTTCAGTTTGAATTTTCAACTATTTAGTAAAACAGCTATGCTTAGAAACAAACTCTTAGGAAAGTAGCATTCATTAACATACTTGTTTAAATTAGAACATGATAATTAATGTCTTGTCTTAATTACTATAAAGTCAGATGTTGACGATTCTTCAGCTGCTGTCCCAGCAGCATGCTCTACAAGTAGCATGAAATGTTTGATGTGTTTTGTGTGCTAGCCTCAAGATAACATTAGGAAAAATATTAAAATGACCTGACACATGTACCTTTCATGTCAGAAATTGGGGGGTTGTTTAGTTGCAGTTATATGCAGATGTTGCTTCATTTTATTCATTTCCTATAAGATGCAACCAGAATATGGAGTTGCCCCAACAGGAAAGTGAATCAAATACCCGGTGTCATGAACAGCCGGGTAATGTGCGCTAACCATAATGCATTGGAGTTGGCTTTGACCTTCATATTGTATCTCTAACTTCAGCATTCAGCATTCTTCAAGTGTTCCTGTTGCTTGGACTTTAATCAAATAATTGATACATGAATTCTGGGGAGTTGTATTTTTGCATGCAGTTGAAAGGAAACCTTTCGAAACTCTGACCAGGGTAAAGCAAGGCTCCTAACTCATTGGGAACAACTGGACTATTGGAGTAAGCAAGGTTACATCTTCAAAACGTGAAGTTTTTTCCACCCATGTCTCCAATAATATTTGAATATTATTCTGAGCAAGTGTTCTAATACGAAGTATGAATCCGCCAACTGTATCACTTCATTTCTAAATCACAGCTTCTCTCAACTGAGTGGATGCTAATTCCAAAATATGCACAGGCTACAATGGTGTTCGGGATCTTTGGAATTAATACAGTATTGAAATCTTTTTTGAAAACTGACCCAAAACCCCAAATTTTTTTTTTAAACAGCTGCTGAATTTACTTGATAAGAAGGAGTGGTTTATCAAACTGCAGCTGTTTCTGATGATAAGGTGAATTAAGTAAGTATATTAGCATTGGAGGGTCCAATAGGTTGGTCCTTCAAGTGTCTGTGTTTGAAGTGCAGATTATCCCAGTTAAGATGATGCCCTTCTGTTT 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@rCer/704/1914_57_CCS ATGGGGAGGCTGAGTGCTGCGGCGCGATCCTCGCTTACGTGAGAGTTGGCCCGGGAGGAAAGATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATTCGAGAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGACAGCGAGTGGCGACGAATGTAGATTTCGGGCAGACAACTTGAAACAAGCTGAAAGAACCTATGCAGCAAGACGATCGGAGAGAAAATGAAGAAAAAGAGCCAGTGGAAGATGATGAGTCTGTCCCAGAGAACGTGTTGAATTTCGATGACCTTACTGCAGACGCTCTTAGTTAACCTGAAGTCTCAACAAATCAAAAAAGTCCGACTCCTCATTGACGAAGCCATCCTGAAGTGTGACGCAGAGCGGATAAAGCTGGAAGCAGAGCGATTTGAGAACCTCCGAGAGATTGGGAACCTCTGCACCCTTCTGTGCCCATCAGTAACGATGAGGATGCGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACTGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACACTCCCATTTATACCCCCTTTTTCATGGAAAGAGGTCATGCAGGAGGTGGCAACGGCTCAGCCGTTTGATGAAGAACTTTATAAGGTGATTGCAAAGGCAGTGAAAAGTCATGATGCAAACTCCTATGTGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATCGCTGCCCTGCACCGGGATGAGTGGTCCGGCCGGAGGACACTGCACCATCAAGTATGCTGGCCTGATCTACCTGCTTCCGTCAGGAGGTGGGCTCCCACGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCACATGAACAAACAAGTCGTGGGAGATGTTTGAAGAGATGATTACCACCGCGGAGGAATTTACCAGTCCCTGGGCATTCCTTACCACATCGTGAATATTGTTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGGCTTGACTGGAGGCCTGGTTTTCCGGGCTCAGGAGCCTTCGTGAGTTGGTCTCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATTGCCGATATGGGCAAACCAGAAGATGATGAGACAAGGTGGGTTTGTCCATATGCTCAAGTTACCATGTGCGCCACTACCCGTACCATCTTGCGCATCCTGGAGAACTACCAGACAGGAGGGCATCACTGTGCTGAGAAATTGAAGGGTTCATGGCGCCAGGACTGCAGAATGTCCCCTTTGTGAAGGCCTGGCGGCCATTGACCAGGAGCCATCCAGAAGCAGAAGAAGCAACATGAGGGCAAACAAGAAGCGGAGGCAAGAGACGTCACCCTAGAAGCAGGCTGCAGAACATGGAGGCACCGATGCCTGAACATTCCTGCGTCCTGTTTGCTTTCATTTTCTGTCCGCTGAGATTCTAGAGCCTGCAACAGCAGGGAAGCCAAGCCCCATTCATCGCCCTGCCCCCATCTGACTGTGGAGCTGAGAGGGGAGCAGTGCCGTGTTACCACACAGATGTTCTGTCTCCTTGCATGGGCTAGGAACCCATCGCTTGATGACTGATGAAAACCATGTATAAAGCACTCTCTGGGGAGGGCTTAGGACTCTTCCTCAGTCTTCTTCCGGGGCTT 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3,796-15%/00/33+2#-6639931)6940532444/6200520,+9346498228.21(,(6032-8+9-)'/211.25)31/+97;:49.,/69.;66::80137&8323*5879547939.4:4-0584:9:82++1/6524323-+16**882018+7810795865288,.*0.183:8*-9<7022052-%)462169;2.67/-030)52,2/)*,*,0*00.110'69.94,41534>;9:98:83=9663:67+19-3198:4:;9(<:893057<:64:;762378-),*<:>>29>87<6'1:61-0845<4:82844)17+=/1:;)+7;;0(#:19:186-<47/2$25.353&6:./1312/,*#2/2/28:9<229;9.=:6><5776513119755161918;;/4:8=;<9<9:477/--;.1,48/46309:1:623*619;844552.7+25,82,$#.),003642-60/,+12-0%1/3+((436/79240)&21*57525++)/*335981-402*22.(1/,-,/1)2510996($+75,6-94-3.3-08::4'40)54/6+60*.2(*0**112815+29-90022440)-0/(8595;3.5/442.*00226'55.23///++(,21450/+12/-1,05666416/3)54-'/.0,1+-(*.0)*0*.2')(5-/+-*-,&)(/,&,.+)(&)(32151-.&,.*-.+)&$#(&#(**%$$%&%')%$&**+++((').,'+)'(&%"#$'&,(,,'%#'(*$&'('&'+(()*'&''&%%)+*#('$(''$'&$%%&+*,($"#'"%$%####)$)+-,''$##$%$$$"%)))),(&'.-,,*$'&,.&**+12201/+,()-(*&*.%(,,2,.00(**,-$%&%0,1-&,/21+.#%-*&"+#*,''$/)+-/,)/-/),%$,+*-'%*/,*(0*-(-%/(,+%*/+,,).+(*'+#%'.&,,$..&),&/'0/0,*&%$*.)&##%$%$(+,&+*'('*%.(+0+*($(,)')%'#&'',----&,,+)+)#-)*&,,*,+'0++&%(+%()-,,,+*,)-*)*+%'/-)&""')+%+,-.')$&'$#%)**+%).+$',-,2/20.0*(**+--(,+&)/1/.-#.0-./'2-*.1-.'&',+&*+('+(*..0('%%#"'(+-,$%,'%*)')(,))*,%*&$)%&'$(-&#')&)($(,(#*(%()$''()('%,+-,,%-,&+(&(*+&''&&&+'*%+&-#'+$+-*+("#$$&%'&%+'$&(&&&#'%%%%&#'*$)#)*&&$-&%($'*-*)(($#$"&&#'%%""$#*-'(*(%&+('%$#&$$(%)$+&($))"#&&'$)(**+''%&"$,+(*(,-'$''''++&('(&'()()+$'((,,--.--*)%"%'#+,('#$+++,)(,++,("**#,$&)-*),-**-+,)#"-*%##*,&-(#*#,,-)).(',-)&,-(#()'))+(,,+%"&+%$$&$&%%#&'"$%$+&()&#&,$%(&'-+*(%#+---'.,+)&$+#',,''&,*(*(,+))-.--.$+)-,,+(,(&$)'&*,((,)$&&$('#+---)-+--'(%+((&'*+),'+(,)(+)(),!$'%'$((*$$#%')++()%'(--+-(+#)((*%$&'*,,--)(*(*'$"%%%'-,)-)((((')'##(&(,.'(+&,-*--(()),'',(*,')()')&)%(,*)()-**((*'%-,$"$*)+(%+*#,+(*%#$#$'&(((%*$+'(&%*'#)((#'--+-)$"&++(%*+*'+,-&#-(-.-,+&&+'('%(&,--(&*.)'$"&'$()& @rCer/705/0_62_CCS TAGCAGGAGGATCGCTTGAGGTCAGCGAGTACCAGCCTGGACAACACAGTGAGACCTCATCT + S%0+-((/(./258.*/(5+',/.($-.316/8+7;8>/@75(223+60.2:>@/4-36*24 @rCer/706/25_1932_CCS ATGGGGAGCAGGGGGCGGGCGGACATCTTGGGATCCGGAGAGTGGCCGGGCCGGCAGAGAAGGGGCCTCGGGACACCAGGTCTGTTCTCAGAGCAATGGGCCGCGGAGACTGATCTGCCGCCATGATTGGAGGCTTATTCATCTATAATCACAAGGGGGAGGTGCTCATCTCTCGAGTCTACCGAGATGACATCGGGAGGAACGCAGTGGATGCCTTTCGGGTCAATGTTATCCATGCCCGGCAGCAGGTGCGCAGCCCCGTCACCAACATTGCTCGCACCAGCTTCTTCCACGTTAAGCGGTCCAACATTTGGCTGGCAGCAGTCACCAAGCAGAATGTCAACGCTGCCATGGTCTTCGAATTCCTCTATAAGATGTGTGACGTGATGGCTGCCTACTTTGGCAAGATCAGCGAGGAAAACATCAAGAACAATTTTGTACTCATATATGAGCTGCTGGATGAGATTCTAGACTTTGGCTATCCACAGAATTCCGAGACAGGCGCGCTGAAAACCTTCATCACGCAGCAGGGCATCAAGAGTCAGCATCAGACAAAAGAAGAGCAGTCACAGATCACCAGCCAGGTGACTGGGCAGATTGGCTGGCGGCGAGAGGGTATCAAGTATCGCCGGAATGAGCTCTTCCTGGATGTGCTGGAGAGTGTGAACCTGCTCATGTCCCCACAAGGGCAGGTGCTGAGTGCCCATGTGTCGGGCCGGGTGGTGATGAAGAGCTACCTGAGTGGCATGCCTGAATGCAAGTTTGGGATGAATGACAAGATTGTTATTGAAAAGCAGGGCAAAGGCACAGCTGATGAAACAAGCAAGAGTGGGAAGCAATCAATTGCCATTGATGACTGCACCTTCCACCAGTGTGTACGACTCAGCAAGTTTGACTCTGAACGCAGCATCAGCTTTATCCCACCAGATGGAGAGTTTGAGCTTATGAGGTATCGCACAACCAAGGACATCATCCTTCCCTTCCGGGTGATCCCGCTAGTGCGAGAAGTGGGACGCACCAAACTGGAGGTCAAGGTGGTCATCAAGTCCAACTTTAAACCCTCACTCCTGGCTCAGAAGATTGAGGTGAGGATCCCAACCCCACTGAACACAAGTGGGGTGCAGGTGATCTGCATGAAGGGGAAGGCCAAGTACAAGGCCAGCGAGAATGCCATCGTGTGGAAGATCAAGCGCATGGCAGGCATGAAGGAATCGCAGATCAGCGCAGAGATTGAGCTTCTGCCTACCAACGACAAGAAGAAATGGGCTCGACCCCCCATTTCCATGAACTTTGAGGTGCCATTTGCGCCCTCTGGCCTCAAGGTGCGCTACTTGAAGGTATTTGAACCGAAGCTGAACTACAGCGACCATGATGTCATCAAATGGGTGCGCTACATTGGCCGCAGCGGCATTTATGAAACTCGCTGCTAGCTGCCACTAGGCAGCTAGCCCACCTCCCCACCCACCCTCTTCAACAGGTCCAGGTGCCGCTCCCTCTCCCACCACACATCAGTGTCTCCTCCCTCCTGCTTTGCTGCCTTCCCTTTGCACCAGCCCCTGAGTCTAGGTCTGGGCCAAGCACATTGCAAGTGGGACTGGTGGAGTAGCCCCTGGGCTCCCTGGACAGGGAAGTTCTGAGGCTCCTGCTCTCCCCTCCACCTGTCTGTCCTGGCCTAGTGCCAGGCTCTGAGTTCTGTGACCAAAGCCAGGTGGGTTCCCTTTCCTTCCCACGCCTGTGGCCGCACCTCTGGAGTGGGAGGGTCGGTTGCACCCCTCACCTCAGAGCTCTCCCAAAGGCCAGTAACGGATCCCCAGCCCTCAGTCCCTAGTCTGCTTTGGGATAGTGTGAGCTTCATTTTGTACACGTGTGACTTCGTCCAGTTATAAACCCAATAAACTCTGTAGAGT + HJ-KJK?@GK;KKK>KKI3KHEG9?JIBH8@CGFIIIKIIJIFGEKGGJ?JHA?IFHJFI;IKJIDHG3CB@FJ>G:DIIB?IFIKIHGIFIGFH@IHDIJJKBDICGJJHJD@CIGKKCFDIKIIGHGFIBF>K6JJKIJII?JBDJIJ@HGKKK*DGKJ?2FEJJFFEEG6JKIKJDCIFEBBGBFDDFHG@EG9FFI>>FGEHJEFBDFFHJFJIHCB7BHDJHKHFBII2EIFFIJ>KFKIE>HD?IKHJIEBGKI?HGHKEHFDIFKFIKEKJJJGIIICIFIF8HIGKCIBD<@BE5CG>IJDKEKIJDKKIBBE7KKJJJGJ8JKKG2IEGKFGJ;JGFKJJIHIIKJKHD5GJIDFKJKJ@KKCG3JKC9JJJEJ7?HAFKGKKKJKKHDAKJF:JFDHJJH@HIKIKFCAKJKKFKJJIKJK>KIGKJK@FB8FIJHKIHHHGJIHIKKIKKKKBKI;IJKKIJ>KKKGGKKJKHJKKEKGDKKKKKIIKKJFHDKFAKI=IK*ICHKJHKDKHBKJAKKKKKKKJKKI'EIIKJKHI=KKJK;KKKKKHJEK?JJFKIKEKKKJKKKJKKKHHIKKHBGJIK>KKKKKFK?KEKJJ:KGKKKKKKKKKKKJKKKKKKHDJHKJKKDKKKJJEKKJKKKKJKKJ:KKIJK:KGKIKKJFKJKIJKKKKKJKJJKJ,KKFJKDKKIKJKKJKKAKKKKK@KKFKKEKKKAKKGEJIH,KKJKKKCKK/KHKC?KKCKKKJJKKKDKHGKKKKK6KIGFB/K7KKJKKKKFJKJGKKK=IKKKHKJJ4JHIAKHKK?KKKKKKKKKJGKIJIIIKKKKKKKKKKAJ5KKIDKGIFHE?JJJ>IKEKHKKK@KJ7KKIHKHA0CHKKHJKKKKKJKKKKKKFKJJKKKKJIFKHKFHKKKIKK5IIKK>KEH-KGHI@KJEKIKHKJ=KJKKKFKKKJJ&K5EIKKKKKKK5KKKIKK5KHK=JKFKKJJGHKJK&KHKKKIKKJGKGKJJK/KJ6KDKJ=GKIEKKKKJJKAKKGK?CEJ(KKJKKJ7KKKH38IIFF:DC>D,G9JJJJ>AKKEECGGKCJ>D=KI<==<>IKJDKC0H==@CGGD=KKKK0;HCCFB:A@>4EHEHD=@FHHJHJCJKDHH9@IE*DDFJGFIA>HKJ:HGJ:DGGAKEJGKBJJKK2CKJJJGKKEF1JJJK=?D6GJIDIHJFJKGJHGK:EADDEAEAJ9JADIE4KGGEJJFFCJDG7@EFIC1>9*B0(I/BJ5I>J9KHJH;AE>A?JJG6AFJ5E=EIBG@K=IBFFEF5EJGHFC:8;A7GKEACB9CJGGDHJJHJGJI;FJJ0KIKGD@D?CK?9JIKHKKBIIDIFJK;JK?JJEKIKJ4ECA1HGJIK@HDJEFBGKDKHJFGHJBKFI;KFJKHKIGKCJJKHCDJJKGDKI*EH@EKGIGBGKKKAIIJKF?I@JJKEIAJ2KKJKK:JIHJGHA$EKK:GJEF,ECIFFJKHKDJ2G9>@EFKK8JEIJFI??GKHAKK@KKKHEKFKE>@JAKEIKIIKEKKJK@HKAH8KFHKGKJJJKDFJHH6@FCKD)DII@FCAJEBKEKIIKGFJIH>BG>EDABKB?JK;D9KJGKJIDDHIJCJI-KII4HIK?FKIG%KJKKEKHKI?FKIKEKKJJKAJFF?@BBB4GEC:GGD@BIIJGEBJIGKJJHHKHEC?JCHCHEB?@K?KIJCHCIHGKJKC7D3BDKDI8KE99DDGKJ4GCADBD@?=A6FEHJBBJ8JIKCHDH>IJE066F=@JJ9KHGJFKDCCHHE4GEEH1KJJ;IGG3A29>CA%BEABIJKG=:@GKBAD;DFG8BAADH@1FEEAIGJ;6;.4F82EI7GIKE>BG=D;F4BEJJI9KAFHI6EI8C@C7?>GJ+:F7AF@G;I8KGBHHJHCKHJJ:KFHKADCKHFE6;.I>?BD==:EHJDJBDFH@@ICH>ADFC?HIJBBIEJG7IJGHKE8>:BCBGJAEAAHIJJKJJJEC6CB8IKDGKHKJGE6@;JIG=JHCKAJGKIIJJJIKJE)B?CDCGGKKK@5:BCK7JHJKJKJKIEJIJ;JI=KKKHKKKKKF;JGEDGKGFJKKJKK4GJFJKJBBIIK@KK?IEHJIDJJKK:JJKGIJKJBCK>JKGJBKKIHKH@JKHKJAEAIKHDKJKJIKKK0DIEKKFHHDFG9JKKK3IEKKJHKKJ>HID?JGJEFGKKK;JEFJF7=JKHK2K>KI9FKJKKJHGDJIDJAGIK?KIGIJJEF;EJD1>BF=>./AKCKKKKKKKHKKBEGKKJKKJJBKKKF>JKKGJKKCDGJ1EKKKCH?DKEGKJKJ?KKKIGKIKDKC4IK0KHJFJJJKK-JK@KK?JG@@K>IJDIG&J>FKKIFCJHGEGJKJ?DF;KKKBFHEKKKHKKKJKJJIKKFKKKKIJIKKK=KAFIHKIIKDKJGKH>KHFJGJCBKJJKKJKGJKKDKJ9KKEB=GHFKDKJ:IKK9I;E,AK;FIKGIFK0JCIKKEKEHAFGIKGKDKKKJHIKIKA:KKJJHJDEKICKFKJH@BBIJCBHJKE@KJGEDGHKIGD+DKIKJKHJGKBHGKKKKHC;F>EDCJKKFKJDFF.?AHBFBIKKKKIJKK;IKJJBKKIKHHKGHKKKCKKKCHIKJIKJKKKFKEJJKKHIJKJDCJKKK4JJKKIJKJKJ2JKEKIGKJJJKJKCKGIKIJHKJK3K4<>KKKFKKGK?D@KKCJJJIJKK>JKCKJKKE-KKIJKJKDJKIJKKJIJBEJKKKHJKJJKIJKK?JJKJJBKHKKKDGKAJKKKKKGKKKKKK2KK@KDJKKKHKIA7?CAKKJKDGEGKIKJJKJIFIJK@JJGJKJKBHKKKIKK,=ICKBKJKJIKJJIAK=9A?<2HI2IKDKKIK=KGIKJKKEKIJGKIKCFIJJKCKKH*JJKIKJKAKKGKKJKKKKIKJKIDE?KJIKK?KK@KK>KKKK?KGKKFIIKKJHIKKJKJKJKKJKKFKKKGKGKKIJKKFKKGHKJKKBJKHACIKKKKDJJKKKCJKJKK)IKKAKDKKKKKAJKKJKKCKKK=JIIKJKKKKKJKKKFKEJKJKJKKKKKGKEFKIKAGEKJ?KKIKKKKJKKJJIIJDKKKIKJKKIKHKJKKKKEKIKKHJH=JKKKJKKKDKKKIIHIKI3JIHKKJKKK>KHFKKDKKIKGKGKKKKHKKKKJIKGKDIJKJJKKJDKKIKGKKJKKFJKJKKGHKKKKKHKK>FDJJKKHKKIGK @rCer/711/25_1659_CCS ATGGGGAACGCTGGGAAACTCGCGGCCTGCGCCACCATCTTGCTTTCCTTAATCTGGTAGGACCGTGTGTCAGAACAATCTTGAATCATGAAGCTACTAACCAGAGCCGGGTCCTTCTCGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAGCCTCAGGACCTTGAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATGCTCCTCTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTCCAACAATTTAGGAACCACCCATTTGCTGAGACTTGCATCCAGTCTGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCATGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAACCATGGCTTACACTGTGGAATGCCAGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTACTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGTTTGGTTTATCTGGTGTGAAGGCCAAATACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTCTTGTAGCAGAGAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCGTTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCGACTCAGCAGCCATTTGATGTTTCCGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTCGGGATTTATACTATTTCCCAGGCCACAGCTGCTGGAGATGTAATCAAGGCTGCATATAATCAAGTCAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCTGGATACCTAATGTCAGTGGAGTCTTCTGAACGTTTCCTGGAAGAAGTCGGGTCGCAGGCTCTAGTTGCTGGTTCTTACGTGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCTAACGCTGATATCATAAATGCTGCAAAGAAGTTTGTTTCTGGCCAGAAGTCGATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGCTGTAATACTGACGCACACATTACGGGAGAGAGCTGAACATTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAATCTCTAATATAACATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCTCAGCTGACCTAAAGTCAATAAAACATTCTGCTTAGGTGTTTTTC + KK-KKKGKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKJKKJKKKJKKKFKKKKKKKKK?KJKKKKKKKKKKKKKKKKKKKKBK=JKKKKKKKKKKKKKIKKKKKK4KKKKKKKKKKK;KKKKDKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKCKKJKKKKKKKKKKHKK;KKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKK:KKKKKHKKKKKKKJKKKKKKKKKKKGKKKKKKKKKKKEKKKKKKKGKKKKKKJKKKKKKJKKJJKKKKKKKKKKKKKKKKKKHKKKAKJKKKKKKKKKKKK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKJKKJKKIKKKKKKKKKKKKKKKKKKKKKKKKKK;KKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKFKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKJKKKKKKKKKKKK,KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKAKKKK>KKKKKEKKKKK@KKKKKKKKKKKKKKCKKKKKKKKKKKDKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKIKKKKKDKKFKKKKKKKKKKKKFKKKKKKKKKKKJKKDKKKJKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKJKKKKKKKFKKKKKKKKKKKKKKKKK-KKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKJKIKJKKKKHKKKKHKKKKKKKKKKKKKKKKKKFKIKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK@KKKKKKIKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKFKKKKKKKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKIKKKKKJKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKK:KKKKKKKKKGKKKKKKKJKKKKIKKBKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK&KKKKK @rCer/712/25_1557_CCS ATGGGTGGCAAATCCACACTGATGAACACGCTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGAGATCAGATCAATAAGGATGAGAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCCTGAAGTCCCTGGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATTATTCCCATCATCGCCAAGGCTGATACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCCACGGATGACGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGGCAGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCCTGGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGGAATTCCTGAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAACGCCGGGAACTGGAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTGAGGAAGGACAAGGACAAGAAGAAAGCCAGTGGCTGGTCTTCCATTTACAGTGTCACTATTCCCTGATGGAGCTGTTATGTGCCGCTCCAGTGAAGGCCCCAGCCGGGATGCTAGGCCTAATAGTTCAGCGTGGAGATGGCAACTCACGTGGTGCCCTAGGTGCAGCTGCGTGGTCTGGTATACATGCTGCAAAATTCACCCAGTTCCCCTCATTTTAATTTTTCTAACCTAGAGCTTAATTTTAATAACTTTAAAACACTTCTAAATATTTATTTTGGCACCAGCATCAAGACAAATAATATCCTCTCCCATTATTTTCATAAGTAACACAGATTTCCTGATTTTTAAAAACTAAAAAATACTGCTAAACCTTTCTTATGTATAAAGTATGCCTATCATATACAGGGAGAGGTGGGTAATAAACTTCCTGTAAT + KKKKKKJKKKKKKKKKKKKJKKKKKKDKGKKKKKJKKKHKKKKKKKKKKKKKKKKKKKGKKKKKKKJKKKKJGKKKKKKKKKKKKKKKKKKKIKKKKKKKJKKJKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKIKKKKKK1KKKKKKKKKKKKEKKCKKKKKKKKKKKKKDKKKKJKKKKKKDKKK;JKKKJKKKKKIH6F@GEHBFBBEF@GKKIJ@##-GCFG8/3CEKIJGE:HJGFIBHJHCB@II?CDED5IFJKHE:DD8DBDH7HKKKGF4GGEDCJICCKKIKK?GKKKGI>JKKID>=FKBBKKIGHJIIGAFJ7JK=JK@KHKFJAIKJ@J?KFJCGFHIDBCKEJJC@@GJKJHEIFI@IKIIEKJEI5DFEHFJKHHHDFJKH?J5JH@F1=KKK:@IKGI6JIJKIJKDHIKHJIG?>GIHK?KHJKKE)CKJCGHKKJKKI:JH@CKKKDKKKG7H8J7AID@&??AIKFJJIKJI;K@IKKKAKJDGACIKIJJ/GKHK58BK1KIJKK>KJ%JJKKKIJJ5EIC;K9G.E/HIEJJAKDCC8IKHIHGK>KH=HHJHEGHDJDJDHFAIFIJKCJK7JIJFD:AI6K?;CBBIHJ8IEJA:I5IJF2CK3HJCHG5K?CDAJHIFFHFKAGKKBIK@KDKJHIC8A@DDDJFKDDJK@JKJIKDKKCGG2IKKKFJHFFJKCA;CGAI>AJIIIJB?J;EJHIFKKKBAGJ8JK?GK>HHKHAHID6IKHDKJJJBJJJIDJK.%7JIAJJKFKJFJKJ>IF6ADDGJKGK*=JJFKJKI>9?JIJJKAIIKIIIJIJKEIKJJHJJJKKKKJIHKJKEGF>IJFKCCJ@GHD7,ABKGKCKGCKBIKGD8BKCKJJJ(#HFF>?2EJGGICB?F>FKKJ-EKKKEBGHEHH4FEJ>@<7HGKJ,KFJGKGKIICK8KKFIJIHF7FCAJKJIHJK=EJFFBE:KKFIHJII9JEEFHHG=GCGG?HEJKJJ8E>KHD9?>AEEGD0@BCGJ>EBJIKCE@GKGHIGHCI8C:AJK*KICD8FAIDKKBKIKIID76:?I?KIDGIGK.F0FI@GF=J&EA?9>9D=E@A.FECEI>JHIAH=BJJ:KICDEDAGCE0GC>GFHIJ0GIIB:HHDGFIEHB?,EHG/F@>H@E8DHFEDH:EAF?DG>;?A@@EE+FGGE,A?EC?AEFE=GHHH6EDEHH>FDG?JAJ;F?C/=,GCAHCAFAACJ3CDH?HGB?FHHBHEBIIIG6@GGJG2?GCH9<-8B1>=@FFD*&D@E>J2F:H1?IG=BF?A;DFIIIBGBCIG;%8F/?8II/HG9HGEHIEA@FC+FGGGAFJEH@IIGI;GJEG=BAAFIIJ@HCD>>GEIHCC:G@/57 @rCer/714/25_2226_CCS ATGGGTAAGATGGAGAGGCTGGTGAAAAGTCATATTGGCAATTTGTATGTAGTTTAAGTGGAATTAAGCAAAGGGAGATGCTTTTGGGTTTTTAACATGCCACTTTTGAGTGAAAACATCTCGTGGAGTCATTGTGTTCAGCTCTGAGAAGAACAAAGATTCATACTTCTGTACATGTGGTTGGATTTAAATATCCTGTTTTTTGATACTAATTTGAAAGTTATTTAACTTCTTTTGATATCTGGGCAAAAGTAACCATATGCTATAAGCATTTGAATATGTTTAATTTGTCATAATAGCATCTGTGAAAGTGTATCTTACACATTATATAGAGGGTTCTTGTTTGAAATTTTCACTTCTTTTTTATCTTCCCAGTACATCTTGGTCCTCATAATGGGCAAAGCATACAACGAAGGCAGGTGGCTTAGGGGTTATAGTGGGGAAGTGGATAGGGGATTCATTTTCTTATATGACATTTTGCCTTAAGAATATAAGTGTTTTAGCGCTGCTGACTGGCATTTTTAATATAGGTAGTGAAAATGACTTCAGAAGCATGGGATGAAATAGAGGAAGAAGAGTTTTTATTTTCTGGCCTTAAAAAGTGCCTAGTAGGTCATTTGAGACCTAGAGAAGTGCACAGAGCTTGAGCAAAGGCATGAAGTCCCTGACTTTCTTTTCCTTTTTGTCTCAGTATATAGTATTAAGATGCCTAGAAACATGACTCTATTGTCCCCTCTTGTATAGGCACTTTATGTTTCTTGCTGTCACTATAGCAACCACATACAGTACGGACAACCTCAAACCTGTTTATATTAGTGTAAATAGAAAAACTATAGACAACTTTCTAGATTTCTCTGCAGGCATTTTTGGGAATGTATGTATAATAGGCTCTGCTTTGTATACAGGAGATAGTACCACATCATCGGTTATCTCCAACTCCAGTCTTCTCTCAATTGCCCAGTTATATCTTGTCATCAATCCCTTTTTCAAGGCTGGGAAGAGACAAGTTTCTCCATGAAACTTTGACCCCTCACACTCTCCAAATGTAATCTGGATCTCCTTGCTTTCAAGATCAGCTTCCCCATAGCTCAGGTATCCCCTTCTCTCCTGTGTCTTCATTTACTCTCAGTGAAGATATCTCTGTCCTGGAGGTTACTTAAACTTTCTCTATAACCATTGCTGTAGACAATGGTTTTCAAACCAGAAGTTTCTATGCAGCTTTTCTAGTTCCTTGCTATCTTCTCACCACTGACTTGAGGCAGTGATTTGGACCTTGCTCATTAGAGAGCATTATCAGAGATGTGGAGTCCATCAGAAGACCAGCTTGCAGTGTGAATAGCATATAGATGCCAATATTATAATTCTTTATATTTAACATTTTCATGCTTCTTAATTTAACTTCACATGTTGGGAAGTAGATTCAGAAACTTAGGAGAAATACCCAGACTCTGCCACTTCCTTGAGTTACTAGTTAGGCATGGGCAGGATTAAGTTTTGTGTGTATTATCTTCCCACTACCAAGAATGGTTATGTTTCACAGAATACCAGTTCAGTTTGAGTTGGAAAAGATGCCAAACCAAATTTATATATAGCCTATAACCTAAGGGCATTCTTGAAGCTATTGCCCACATCCCATTTTTAGTTCATGTTTACTTACAAAATAGAGATAAACATTAGATGTCTAAAGGAGTGAGTAATGAAAAGCCTGTCCTTACAAATAAACCTGTTTAAATGGGCTTTAAAAGACATCAAAATAATCACTTGTCATGCATTGACTGTAAATAGAGATAAAGAAATACGTCTTTAAAGCTCCACTTATACAAAAATAAAACTTCTATATCATGTTCCCTCGAAGAATGTATGATAGTTTATTTTAAGACCATTATAATAGAGTAAAAAGGAAAGAAAGCCAGAAATTAGAATTTTGGATGCTAAAAAGTAACTTTCTGGTTAACCCTAAAGCCCTGTCAAATTGGGAAGAAATGTTCCAGGATACACTTGGATTGGTTATGCAGTATTTCTTATCAATTGTCTAGCCCTTGTGTATTGTTCTGAAAACTAAAGTTTAAATCTTTATGCTGTTACCTGCTAGACATCCCGTTCTTTGGTAAAAAATTCCCATAGTCTGTACTCAAGAAGTGCCTAAAAATGGACTTGTGTTGATTTTAAGCCCATCTAATAAATTATATGTATTTTCTATG + HF9JH?>@BH;9I>JJAJFC?E9A1DKKFHFCJH6HHJIJJHJIHG4?HFIFFJKDBH:J9EC,FHE1HJKIHK;GJJKICKH/FKKHJCCGJJFJHF.IIIJI=KJJCIEIIEFDGAKJJB1CHGJKJIFJ3EFB=$JJFGEEE=IJ>IHB>HJKJK:KIHHKFFKJ=JEGG:BAKCKGKKKJKDJHGEJF%AECJF7KKKAK;CHDGBJJK?GIJ8IDDH1GII?=KJ;1JKJJDHKKKDA7JICFFICKJJF5JKECJ8EJKFJIKFIJIJBFF?>GHCKFJ;HBGIGGFCGHHKAGCKDJFC%IHGKGD6KID4F+ICIIHJHKKHFF8JKIIE?G=@@DG=GH(JHIFJII+FDI;BIHD;BFIH*KJFG0IGCH?DEIFIHEB;H;>BG=FJIGIIAI:JJCKKJI7CH9GCHDJHJ@IJI:JGGKK@HGGJJHJBKII6IJBIIBDK&IJKJ=KKHB>KEKIC4)IKJ/IIJFH3IKKIHHC4GKKKKKGJFJKAIJGKGK9KKIKKCK;9IHJKBKAKKAGEIJJJ?IKAH7KKKDKK-KHHJKKJJIKKJEEIJIEI?KH@IKDKFKJKK=KJJKIKCKIIKKGKKKHDKJKKKGHHKG>GKIJKCKKKJJJKFE%JGFHJGJ4KEKK6K8JK-B>HIJFHKFKKKHKKKKKK@KKHKKKJKGIE&HKJIIKJ> @rCer/715/1853_58_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACC + ?JKHH2HJ@FKHJKIHK@DJJIKAJEJC,?CIEFCFKJJDKKBIJKKJKKCHK@HIEKDEHDHJK+KKIKKKIJKJDJKHGJE9D@JIJKIIBGHIK>IKJJKHHKJKGKIAHGCFKBJKKFKFJGIFIJJKJHDHHKDJG8IFF>E6IAJKGHHHJJKIH=KK@KIIIGEDJKH?JJDAKJJKKKKAKIJIK;JKIKGJEGDKHJJIKIJKIJIKAEHIJJ@BHEII3KJFKAAJ>IGJGKK:IKFCIGKJHJ6IIKJKK:GEJJKGE7G=IJJFKFEIEKJGFAIK$?<=IJGKICKHEFJJJD?JJHJ@B;;EEHJI=IKJKKHJJKJDHKHFEDGEIHHG?HIEHKHJKKIJHGJHJIJIKGIIIJJHJDKKKKGHDHKJIKJIGJ?JKJIKKKKE+BIJ?IKKEKFKJKEJAKCJIIHJKCIJK@AGKIJKD8G8IJKJIHFHEJ?KFJKE?FHHG2FKJFJHFH?IFJJAKFH:JEEJCJKHJKAEEIKKCIHH;G7FHK@JJJJBKIGIII?HBHHKKCBBKKHDECDK:B@=??KIEHJGKFJKCHKJIHKIICKKIGKHKKDJG.GJCCKJJH?FFF=DHJKHHFCKGKKKHEJICFJHHIKJKHG@DEDF9DBJ;H;IIHKHAGJH?HKJKJJGKKKKJKJKIIKKKKEIIKIKIKHHJ2KJKIKIKFKJKHKJKJKIIFIKIDKKKBJFKKKJJJKKJIIKKBKJEKFKCJKAJJJAIGJFA?KHJBJJDIJJKKDIHHKKIKHKKJ>DJIGIGJKKKIKJKKKHKJKKIJJHCJEHF)GGK6JKJIHKHJKKBJKGKJKGKKKKJJKKJGIIJKDKKKDKIJKKHJKKJK6ICCKJKKCAKJHKIGKJKJKIKKKJKKKJCKIHJIJKGKIJFIIGIJKCJIFE7EBKIJKKIKHIKDAHKJIKKEKKJKJJK=JIKKKKKKHJKK@KKIJEHIJFKKGH>I=EJGKKIBIKJKKGKKHJJJKI3IDIK?KIDJKIKJKKIE(IIJIGIECHEGIHJKJKAJJEKJIJIJHKIKKKKJKJKKJ?HJHHJGIIJJKI%>CKE9IJKK&FBKKKKKKKKK0KJJJ?JDJKJKKJHKKFKKKK:FKKJIBJFHIFI?KJJGKKKKJAKIHJCB;KKKKJKKKKKKKKKJ0KKBKKKKJDIKCFJJK3K?JIKGJHKKGKJKIKFHKJJ.DH?GEIJJKKG5IDH6CAIJHDKIKG9FHCJBIHIHGKKHKKGJKGI4KHJFJI:K@KGG>D>8?KKKBFJIJJJKFIJKIG+IAJKICJKJJKIKCKJJKIIJI'IJKK@IJKJ?HGKKDIKKKKIKKHII@K@KKIJKHKJ7IEIHKK8HA@HHI+HGJ=GKIDHG?KKEJJIIKIJ=BK9JKKDHDFGKBKJBFJHJEJHFI:GKBEGH;GGEEKJJKKK@JHBDIHIK* @rCer/720/2079_61_CCS ATGGGGGAAGACTGCCAGCGCCGCCGCCGCCGCTTCGGCCCGGGCTCGGGCCCGGGCCCCGACCCCGTCCCGGGCCCCAGCGCCAGCCGCCCGCCCGATCGGGCGATGAAGTGTCACTATGAGGCGCTGGGGGTGCGGCGCGACGCCAGCGAGGAGGAGCTGAAGAAGGCCTATCGGAAGCTGGCCCTGAAATGGCACCCGGATAAAAATCTGGATAATGCCGCAGAAGCAGCTGAACAATTTAAATTAATCCAGGCAGCATATGACGTGTTGAGTGACCCTCAGGAAAGAGCATGGTATGATAATCATAGAGAGGCCCTACTTAAAGGTGGGCTTGATGGCGAATATCAAGATGACAGCTTAGATTTGCTACGCTATTTCACCGTTACCTGTATTCTGGTTATGGAGATGATGAAAAGGGCTTTTACACGGTGTATCGTAATGTTTTTTGAAATGATTGCCAAGGAAGAACTAGAATCTGTGTTAGAGGAAGAGGTTGATGATTTCCCAACTTTTGGAGACTCCCAGAGTGACTATGATACGGTAGTCCATCCTTTCTACGCTTATTGGCAGAGTTTCTGCACTCAAAAGAATTTTGCATGGAAGGAAGAATATGATACACGACAAGCTTCAAACCGCTGGGAAAAACGAGCCATGGAAAAAGAAAACAAAAAGGTTCGGGACAAAGCAAGGAAAGAGAAGAATGAGCTTGTCCGTCAGCTGGTAGCTTTCATTCGTAAAAGAGATAAAAGAGTGCAGGCTCATCGAAAACTTGTGGAAGAACAGAATGCAGAGAAGGCAAGGAAAGCCGAAGAGATGAGGCGGCAGCAGAAGCTAAAGCAGGCCAAACTGGCGGAGCAGTACAGAGAACAGAGCTGGATGACTATGGCGAATTTGGAGAAGGAGCTCCAGGAGATGGAGGCACGGTACGAGAAGGAGTTTGGAGATGGTCGGATGAAAACGAAATGGAAGAACATGAACTCAAAGATGGGGAGGATGGTAAAAACAGTGATGAGGCTGAGGACGCTGAGCTCTATGATGACCTCTACTGCCCAGCATGTGACAAATCGTTCAAGACAGAAAAGGCCATGAAAAATCACGAGAAGTCAAAGAAGCATCGGGAAATGGTGGCCTTGCTAAAAACAACAGCTGGAGGAGGAGGAAGAAAATTTTTCAAGACCTCAGATTGATGAAAATCCATTAGATGACAATTCTGAGGAAGAAATGGAAGATGCACCAAAACAAAAGCTTTCTAAAAAAACAGAAGAAAAAGAAACAGAAACCAGCACAGAATTATGATGACAATTTCAATGTAAATGGAACCGGAGAAGGAGTAAAGCTTGATCCAGAAGATACTAACTTAAATCAAGACAGTACCAAAAGAATTGGAAGATAGTCCCCAGGAAAATGTCAGTGTCACAGAGATCATTAAACCATGTGATGATCCAAAAAGTGAAACTAAAAGTGTTCCTAAACCCAAAAGGAAAGAAAACCAAAGATATGAAAAAAACCTGTCAAAGTACCTGCTGAACCACAGGCAATGAGTGATGTTCTTATCAGCTGTACAACCTGCCATAGTGAATTTCCATCCCGGAATAAACTTTTTGACCATCTAAAGGCCACAGGTCATGCAAGAGCACCTTCATCATCATCTTTAAACAGTGCAACAAGTAGTCGAAAGCAAGAAAGAGAAACGTAAAAACAGATAGAGATTCTGCCTGTGCTTTTGTTTGACTGTCTCTAGATCTTGAAACCAAAAAACTGAACTGAAATCATCTAAAGAGTTAAAATTTTCAATGATCTGCAATAATTACATTGTGGAAGATTATTTTTTATCTTGTAAAAACATTTTTTTGGTTTATATATATTTTTAAAACATGTTCACTAGTGATTGAATTCTACTTTTGCCATCTGAATTGACTTGAATGTCTTAAAACAGGTAAATACTGTAAAGTGTGTATTCTTGATGTTTGTTGGCTCATGTGGACAGAAATGTACAGGGAGAATTACATTATTTT + <6<<;6(715363>=52:=764/;9-88972256+7;*2=/<;:;6665+68283+;:4'37;6:,789757:42,0$8;<:9,03549296<69,9'586444222,0120345556484.4/247379341422/*-20//+,3049583726;685956902406.41566568:298789;;36505.-4(2157.5.*)4,,)(043,1217+.2430/06601..-/5054.156:,00&304118203-52%2-.4+(+/3657/463.8876251/70662352--5925/0'528)5656,344/1*,1..+79341-.,-87238136463655'3%-/4-,67863/633062&25,.)11.0/214/'537314,&2,-0$,0,22536,0/8340835124788(2842746'3/+,30/5/(049.944852356$20104+13/5-(415-)).&*526:343301-26'0.34.5'/.*%4,./50274*68*82799727236:9873-963356885145'*697,002/412/9471)45895876493635065625)57450../2/1*22,572)33790.3*:665/+*-)$00-342316213433.88324084134*6468/4575842/1/7:91)27603//362*0.5(12.%./3808586:17916516-26+51.3181945'3/:43369/581118,.133948266'45798599+5382:::361789,28655-5*&-.66:/9616/.42677/65-42,/3:46376068335/2-.310-/*'&%/+64.46,/2387,*43513.36,65/+676-80574+24231//27669168237252428783-1*/.)/-3/0)9309:697761-52095/414,5;667153887132755)66,46,+'49831//64/+9767&3414+-2&53188786:9643246;17263717.*7638'22759511*9642675-430/37.132,4/756::7:437/29203.2949636:86945/4433-86298634848/92777221522#7566//386955.4+*810-24320)271060/6/136-3)57977(0903-10/73074-686756737886996;3856-06)084743)3142579+1;5.6,3764568813045:8668285957584.33337551526-642522673---287144):8:9067763,126+,-01/&556--65-20)3,7566921.4249266*4637944802'/.797892:26833411-*-8:3-50'2'.66/,10.0-&22(.57(61/'2253)012-55/.2411.14870435/%(2-538-66--36/4746871475668-557,/12:727854:6909436)57589/5551408859692283-,0%467&94:600849*66;99058522/..540$.0485985,11392076755(9/74400510764/4:899504;45672.522-25416676937/152.95::2526865,4066888../21.)3/4)4)3277,-)80795642947804.9651,0.,,50*41.756452'/4)965/555,.4643:702655%8283875,636:8-7887936,3373/57.964-242454.3763.4%537.86253.0,-./.,%+1)3/0'/323564(241,%43344242/+3200*02210/12)&/*#/0+112+/*...-%%)4)-4550*,-(/#,1,./20*14%+020).02563-.+0/-11,%2-1/)#$..+(*/)04'041&.2,$0/+1)/.0,/13-*),315304525&/0%-.,3//03%,./5.32+211-.$143*3/0-*$%)/-12/12632-*.01*,'//+11/21/+.1/2/+'%%+),1/+3.12212.-.-/3+(--1-1-15360,134* @rCer/721/27_1394_CCS CATGGGAGACATTCCGAAAAATAGGAGGCCTATTCAAAACAATACCTCTCACCTCAAACTTCCATAATCATTGGCAACCTAGCAACTTACAGGAATGCCCTTCCTCACAGGCTTCTACTCCAAAGACCTTATTATCGAAGCCACAAACACGTCGTACACCAACGCCTGAGCCCTATTCATTACTCTTCATCACTACCTCTCTAACAAGCGCCTACAGCACTTCGAACCATCCTCCTCACCCTAACAGGACAACCCGGTTTTCCAGCCCTAACAAACATCAACGGAAAACAACCCCACCCTACTAAACCCAAATTAAACGCCTCACAATGGGCAGTATAATCACAGGATTTCTTATCACCAACAACATCCCCCCGCACCTCACTCCCCCAACCAGCAATACCCCTCTAACCTAAAACTCTCAGCCCTATGCGCAACTGCCCTAGGCTTCCTAGCAGCCCTAGAACCTCACCCTTATAACAAACAAACTGAAAAATAAAAAACCCATCACAAGTATTCAAATTCTCCAACATACTAGGATATTTCCCACCACAATTCACCGCACAATCCCTATCAAAACCTACTCATAAGCCAAAATTTAGCCCTTCTCCTGTTAGACTCGACATGACTAGAAAAATCTATACCTAAAACAATCTCACAAACACACATCACTGCCTCCATAGCTGTAACCACCCAAAAAGGGCATAATCAAACTCTATTCCCTTTCTTTCCTCATTCCCCTCACCCTAGCCCTAATTCTAATGATATAACCTATTACCCCGAACAATCTCAATCACAATAATACACACCAACAAATAGTGTTTCAACCGGCAACTACCACAAATCAACGCCCATAATCATATAAGGCACCCGCACCAATAGAATCACCCCGAATCAACCCTGACCCTTCCCCCTCAAAAATTACCCAGTCACCAGTATCACTAAAAACTAACCACCACTACTATCGTCTCATCTAAACTTAAAACCCATAAAACCAATACCACCTCCATTATCAACCCTACTAAAAGACCCCCTAAAACCTCAAACCCAGAACCCCATGTCTCAGGATACTCTTCAATAGCTATTGCAGTAGTATAACCAAAAACAACCATCATACCCCCAGATAAACTAAAAACATCATTAAACCCATATAAGCTCCCCCACAACTTAAAATAATCACACAACCAACCACACCACTAACAATTAACGCCAGACCCCCATAAATAGGAGAGGGCTTAGAAGAAAACCCCACAAACCCCATAACTAATAAAAACTCAATGCAAACAAAATATACGTCATCGCTTTCACATGGACTCCAACCATAACTAATGGTACGAAAAACCATCGTTGTACTTCAACTATAAAAGCAC 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@rCer/725/24_2137_CCS ATGGGGGTGGAGAAGAAGAAGACGGTGACGATGAAGAGGAACCTGAACCCCATCTTCAATGAGTCCTTCGCCTTCGATATCCCCACGGAGAAGCTGAGGGAGACGACCATCATTATCACCGTCATGGACAAGGACAGGCTCAGCCGCAATGACGTCATCGGCAAGATCTACCTGTCCTGGAAGAGCGGGCCAGGGGAGGTGAAGCACTGGAAGGACATGATTGCCCGTCCCCGGCAGCCCGTGGCCCAGTGGCACCAGCTGAAGGCCTGAGTGGGGCCAAGGGAGGCCCAGGGGGCCGAGGGCCCGGGTCCCCATCATGCCCTCACCACTTTATGCACAACGCCCAGCCTGAGCCCCCTGCCATAGGGAGGGGAGGACCCTGAGGGCTCAGCCAGGGAGGGGTCCCAGGACTCAACTGGACCCCGTGTCTAGGAAGTACCAGCCCCGTCCCCCACGGTCCAGCTTGGGGGAAGGGGCTCTGGGAGGCATTTTCCTGCTTTGCCCCTTTTCTTCCTGACTTACTAATACTAAAGAAGTTGGGGGACCTCGAGAGCCAGACGGCCAGACAGGCAGACCCCTCCAGAGGCCCGCCAGGTGGGCATGGTCCCCCGTTTTCTTTAAGGCAGCACCTGGAGTGGAGAGAGGCCACTCCCTGTCCAGCCCCCGAGGTGGACCCAGGGGAGGGGAGGCTGAGGCGTTTGGCCCCAGTCTGGCCAGGAGAGGCCCGTCCCCAGGGCAGTTTCAGGTGCCAGCTGGGCCCTGAATGCCGAAGACAGTATCTAGCCCGCTCCTGGGTCCTGGAGCCGCGGCCCTTTGTACTTGTGTTGTGTCCATTGTGTGTGTGCGTGGGGACAGAGGCCTGGAAGTGCGGAGGACTATGCGGAGAAGGCAGGTTTCGTGAAGGCCAGGCAGGGGTGGAGGCCAGGAGTGTGAGAGGAGAGGCCCGTAGGGCTGAGTGGGGTAGGGTGAGGCAGAGGTCAGGAACAGAAGAGCGGCAGATGCTGGAGCTGGGCTGAGAGCTGGGCTGCCTCCTGCCATCCCCCATCTCCTCCCCTTCTCCCCTTGGTGCCCCCTTCTGCTCAGAATCTGAAATAGCTCCTTTTTCAGCAATTTCATCTCTTGAACACTGACTCACACCTTTTAGGCACCTACTGTGTGCATAGCATTCCACCAGGACTCATCTCCCTTCCTTCTCAAGGGGTCCTGAGCCCTGACTAGCTTTGCCCTAACTCCTTCATCAAAAGACCCCCCGCCAGCTTCCCACACCTCATACGCAGCCACATCTGCCCTATTCTCCATGCTTTCCAGCTTCCCTGCCCTTCCTCGTCTCTCCCTGCCTGTGCAGACCCCCACCCTTCTTTCCTCACCCCTCCATCCCCCGATGCTTGTAGGCCTTCCATTCATTCCCTCTCATCGTGTGTAGTCTCTGATCTTCCATCACCTGATCTTCTCCAGGACTGTCTTCCCACCCTCCCCACTCCCTGGTCCCCGGGAGCAGCTCCTTCTGCCTGGCTCACTCACAGTGCAGGGAAAGGAGGCAGGGAGAAGACGAAGGTTCTGAGAGTTCTGAGGTTGCCACACACAAAGAAGCCGTGGTTTCTCTGCCTCAGCCACTGATGAGACTAGAACTGGCTTCCCCCTGGAGATGGCAGATTTCAGGCTGATCCCTGCTTAAGCCCTCTCATCCCCACGCTGGTCCTGGTATTGATAAAAGACCCAGCTGGTGACAAAGCCTCCAAACCTGGGGGTCCATGAGCCTGGGCCTGACATTCCAAGAACCACCGCCAGGTGGCGCCAAGCCCCCACAGTCTGTGGCTTGGTCAGCCCACAGTTCCACCCTGGATGGGCCTGTGACACCCCAAAGAGAAGAAGGGGACTCTGGATAGGGTCCCCACATCCAGGGCGTGGGGAGAGCATAGGCATTTGGGAACCATTTTCCTTTGGTCGGCTTCCCCTTGAGCTGAGCATTCTGCTTGCTGCAGTAGATGGGTCGCCTTTTGCCCATAGCGAAATTTTCTTAAATTGAATCTCACACCCCCACCATTTCCTCTCCCTGGGATCTGGAAGAACATCATACATAGTAGGTGAATCGTTTTGTAGAGTGAAGAATGCT 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BB&DDBED>@E=BFI@IF?HB4DCH@DFIDD)BBF-JFEH9HHIF>ECABG63EBFFFDD=ICA??BDHG8JHC?:IFBBF;HGCIC9FGGC@;/<-CABCGHCFFE/IIF?FGJJAJE:F>FJIFCI8GBBD<9HC:>G@I<4CDF:I*=;@:>B9GBG5I=G%FD@;IEJFA=DEFIHHJI@A>CC2HG>EBFIHD7FJBD?EHFDIJE;HEC65DAB9A>G>GDC;FHDE;HHGHC-GJJGFAEJ>AIF@GC>DEE:B;;(A?@DGFIH-GFFCJHH7GCHDCJ8FHG>A@IGGC9G=?GI?IIH7FF>H4G>CFDEGEC;H;CDCC?HHDFF0AE;3?HI=8FEI;CIDFEEG=GH@?1BHEC=JC@FFGFAF-FHBC8CIECA?BCEI8E=ADGGG>I@HFB?)ADCD>HIIFD=FHDHEGHEAIBEA?9GHAICDA5FCHDI>=GH?DA?F9DGDBB?EIHII@BE?JD;?@C7H?CDJCEDIBEI9IEI>=E.@D@<7GIFB9BFEGBCF3AIGJD:CI?HAFBI8EGFC?CDG7FEIFDIFD;IIG;9C?3DBG:5@FF7FHFHHAC2HHCE@BIHGIGHF@1HEGAB7HFHFD3DE9EEBIEH@EI8HD@:7GBDGDFFGDA7EDE=GIHHHF@GIHHEDF@BD72DGEDI?GFEB=ICH=@)FE8DDCGHGJA>JIH8FBF)BE1-F?FFG*HCHBAIAFHGHBABBI7;AHDJJFEFGF=I-EEBDFAGIAJFIIIEBEA?=GI=GGCIEEFICGBIHGJ8FHGBCJE2G=CGDI;CF3G@FDDCEIHFEDGIDFHHGB?CGBGFF=FA>9C6A7=DFIHHH@GAFDBBEE4ED:;GHIEBFHIB;(ECDI>EF>H>AB=DGIGIDFDEAE>>GF-IFD71)45=HF+JJCH@G05GDG;B?CC1IGGGCBGHF>GHFFFJHJEFAJI8IE>/?CIF4EHGHEFFEHHBFGHH,>EBDBFDEFBHHHHHGBD?:BE=@EH5GBAIC>BIH4CIFJGHBKCDFJBHIEHGHH?HBB?FCHC;HCF>7EHIH?I3FE@BFEJFI;?EFGGC=A?7EDAGHJIAA@EIKHGKGD6GD=CKIJJB:IIIED=JDI3JHAIGEHJGBI>GIGGHHJE@JJG=GFC=?CHHI@HG;HKHIFJKHK:KECI7HII>HJ7IJIG8B=DG@J?=IEGHICIF,FGJHE1D=AJFHHGC=?DJGGKKHHHHJJAJJAII@?F4FEFHH=HJJEHFJBJ>JI.HJF>DBGIJIICGE==6>:=>526+89:678==(<>>;>9?>>:9=8?=<7866579=7;9:/#>;>79:=:;8?=8/974:>8;;=<:;=1/55589;;8::?:<<<3:<::>=7;94B>C:09?<;)=9:A<>B8?=9A89:29=;A3BAABAA8B=A8<2;779,=:5<86/12872;:4==>8:=*9385959,:69?::+:5+,24/4;:059==7:6831/-/598=?68=6)97378422762653,8:<=98)4/5+77<=:99=;>2=5>5<47>4>?>>4<2>:58:941473458<9397479*5<:;355<<8>9:=:>9<<1:75196#;;7284;<7+=:2;91:<>99-8=;9030/2.7685748;%92547:)<>>>;/5;-;*7:;9807768/69245:8::;==9>;8=;<9766<2339-451/&27:=9?6:855482;;:::;3=);<<:;;?=><5>=84;70134-1329;55(419<9>2<9>=/=?>:=6=<:=:><><<=><:?8=6=;>9?>404=999>>?>>982::<1=83-8:<8*:;?962=96;<333>27;;81;78:8?7>>;;>;>;=;?4>;897<=/;>=?;>7;=<-<:;=5;=88?<>=<=8:<:;;;6:488=<:;7;:=68:>:3;8;4;;>=>?9<;;>;:74>?7;:?:?1?>65'67>?::88987:;>;4>:>=;=1:>>>=;:;6.<7:=98998074333::8;=?=?=>=<56=>?%;727<89?;8<5??;92;888678=>4?=>>3;8:$89<.96>?=>596:<>?>6,=954:64;:?8<0:>=<;?98=?,64:;<,:9<7??>7=:>>9=>>3;<9:96'510643687;::6<<5;<:7<9;>>>;;<>2;<*=6=;9*79:9==2.(-2(1<=;>4?>6<>=5:9;?>9>:;*<;4#5:::13;<<=<<;86<=;>;2;6<=8:78=-===9;9;7?>>0=:=;7;;3><:;?>5=7788=>=26?>7:;69>=2<>?>>>>9:<><>9=?<96?=7<=99?;?5?>:46+58<=<>9??<7*<9=>:<<(3:6'686:=>3==;;:2<=><=7<;7>==>?5==?>=<>=8?>47/'2<=2<476?=?>>?>0<=<>>*<>>971>=235(:9<8=<:63829;??>>585><3<88;6:86=7=4:38=;==<=>6<=?;;>=<6:59.6133(2591:;<>::9==?85?9::=?>2<6/;;?==<68729(<<5;9>>>2??>><=;?89<<688*:<22;=<9:;=>>>;>=9<9;599;=4:4??<8=?>3===76:=?:=5-183;>;8<9:86;6?>?==:9=;49;>:.9<;,574;<;=68)6061>;8$6;>:9?>4=338:>=<56:798>:>=49?;??83;:85;=499;31:693<=>><45::6=:9=;$318:7<9<>7;>36:=6;<=:>=93?><4><<9826=:=:8;:87=?=6>6;98:;7<867;:959?>?7374937878=?<5<><:8;+7;:8>7:=;6<=15=::*;5=;<7<:<;?==:?/==>=>4=?>59=7::397:8>>=97?/723:80;;<>;*<:;89=>>=?9==7;4>::.28=59-;>?98>9;>:8:;=>.6;::<94>>:>;>894=?>?:<:;84=3<4+==93398/72=9=:.>9;,<96;::<+>=:;?>?:9<;639?=>>9=.:89/14464;7>=8>:=9:38;8:7-;==>??==:6*5;:;>8>7<><:;)66'9:<855:7<;??=<=?;=8778::9<579;0<>=:<9=?9:53:>=>?>9<8=5<9<:?>7.>80799=:<870;3=<::=<'4<==><:;=;>;<47<<8:5=64=7:=9:63<707>>3::?915===?>5982(:::9/:85>?=/=>>2<9 @rCer/732/24_1988_CCS ATGGAGTTCCGTCGCAGCCGGGAGTGGGATCGCAGTTCTTGTTTGTGTGTCGGTGTCATCGCCACTTGACAATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTTGAGGTTGAGCCCAGTGACACCATTGAGAATGTCAAGGCAAAGATCCAAGATAAGGAAGGCATTCTCCCGACCAGCAGAGGCTGATCTTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTCGAGCCCAGTGACACCATCGAGAACGTCAAAGCAAAGATCCAAGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGGAAACAGCTGGAAGTATGGACGCAACCCTGTCTGACTACAACATCCAGAAAGAGTCTACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGGACCTCACTGGCAAGACCATCACCTCGAGGTGGAGCCAGTGACACATCGAGAATGTCAAGGCAAGATCCGGACAAGGAAGGCATTCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTCGAGGTGGAGCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGATAAGGAAGGCATCCCGCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGGACCCTCACTGGCAAGACCATCACCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAAGATCCAGGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACTCTGCACTTTGGTCCTGCGCTTGAGGGGGGGTGTCTAAGTTTCCCCTTTTAAGGTTTCAACAAATTTCATTGCACTTTTCTTTCAATAAAGTTGTTGCATTCCC + ,+%:0/59+444934114:2803581/:79111)3$31/:8*713599.076;9:415352*+1).6166&5)82904)3.14.55/0485:45,2.9/88-640064:/5)/,077314.000(&,,)067::5'*(%+112175398/8/43(3375299.5/6/762:270:+00907..;<2165=>95659+68/,0566-7:38*5858.759.769879.3387,147543-)57463892585/111/+/+/031.54,,./20//,57&-(-1/.,,.,6476,76::;;::=6<:622370+;<:4847.1679/)872209-;53:9-56=998&)0056&*.60.,2052;;9<8874-3<::>.<:9>3<7=7468/63351928135>9536;9=3754<=99.3<;91409+306.1682=759/>891<9542.,*$)+0&+-.-#-'('),1231*0)+%*,-0/+0/0',*))%$'))$'&#%$&&**+,(*()',+/,+/+0)&//+21*-,0.-%&/&//110'0&+,&0,0-/%,/+),)*$,*,$&$,,,(*121.0$*)101+++,(%%+*+-,*,//,,/1&-/&/.0001&0-/0455.4%4/202(.//425..332.(*-(*#125510235)101&*,2325,1&,*30.2-54/435*0105.154,440/.,,(2)423.33//1--*,$-+,/1-**,11.-22(,/---2///+,-..60-.+-/.104251.,-/.-)+,//0,/56516551/'0),,2105.,*0*/60-0.4..26655/*1(02%2102015-1/-0'+,/2/2./0646-0161'./-3-$+*/-201/0+-&/1/.0/00524*12-.5/.**3320+,2.3/1511+010*,.)-+44/,-.,,'-0-+/*,0522,4011),,-+&.453'-.-*/6442,/00/3-20/,*21/621*0.-/,(+/24642,534,545//,00651140365522+16/005165260*,5303%/04056416026252/3-,12/3)55662+2352-1,3'.).//4-*,6551651/)+&-**02.2,0/511/26/1.&5#*.031351.2(2%35*3140/4004562554333-)0-000-52)*4544+1*11)5335//.1560*/*1554&04-+14-,1./10,13(22403./264./30&/('3100031.2/+'--).3+1.0002+23,21/$010+5130+0-'&21,'(,//.(3443&3*,.5-01/1*1%.0305/30.'/33/+.445-402-2.&'.012653265016563/44..135.2.141-.5535-5+,.21654),+-/,(3.52*000033410./50,1246.),2451/53-/00+5010142463361./--*/24/005.606$&*11642-16231$1113540+(%--22520.11/(.01.-/*033-10/1/-2*,&&45%&'54/66504/5-.1315556.640.41/53.*5.1226214.4133)403,3'+/3-+,/3,65.320*).*242.(55,.(*,1123#%,*)3%03-5311/2'0(/1/)13(/006021./2.1///651).4/244345).3*-.)/20020-3*//24*,,0/.531+/64*34/5+,02,001/-4265,362-120**1-041411/12++105+4064.56265)/-353/164/6,.,545-4-42./.63/03360(/'/0))*,2/65-/.1422.1'(1/.64321,32555030*1*063.'0/1.&,)+*-0&+%,/1-0645*1./*10261-.,*,,00$.+&++',+)-*/,565&*)2-.-./*,/+.1,24+400.35310.2(35-,/1.00-5510/+,-)/&.120/4.-)41/022000,55200)*55 @rCer/733/500_85_CCS GAGCGAGCATCCCCCAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGATGGCCCAGTCCTCTCCGAGTCCACACAGGGGAGGTGCTAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTTTAATCTTCGCCTTAATATCTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTGAGACCAGTTGAATAAAAGTGCACACCTTACAAAT + +*)0-+,*,/3340)2'3626115/23/28,6,2122)+38*85;84838./36902/3642236&./-45(17369/,5)33,.-1-*-7495:20/4.1)528312(,.622*$"-*00/+0*10-')+(.0211,4/1.*,+'$+%+0./1&.2(*++0,-)32-34,45402+.,'$%$&#"#+34,*,01/3$1644.25*5+*1/30,/(*)*.(-01110**$0+-.+*550..2/+,.$-330.0'1555),+33*,10/%24-,.*.0),*&1/).-,+**#('#&'-%..+.--+/(33(*/55,0.110,+%$#&$'$.,,+,+/',/.%%$))*&*),.-,&&02.11,/)-*,**+0+&/-10.'*&,--,0.*'(%(0(*.0,)-)0/-.)1.-&+(-0,) @rCer/734/1795_54_CCS TAAGGATCATGTCTGCGAGCCAGGATTCCCGATCCAGAGACAATGGCCCCGATGGGATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTTTCAGAGTCTCTTCTCCGTGGCATCTACGCCTATGGTTTTGAGAAGCCGTCTGCCATCCAGCAGCGAGCCATTCTACCTTGTATCAAGGGTTACGATGTGATCGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCAATTCTGCAGCAGATCGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTGGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGTGCCTCCTGTCATGCCTGTATTGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCCCCCACATAATCGTGGGGACCCCTGGCCGAGTGTTTGATTATGCTTAACCGGAGATACCTGTCTCCCAAATACATCAAGATGTTTGTACTGGACGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCTACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAATTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACGCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTCTCTGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATCATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATCGAGACCTTCTATAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCCGACCTCATCTGAGGGGTTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCGGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAGGGGACTACGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTGAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTATTTATTGATTCAGGAAACAAACACAAAATTCTGAATAAAATGACTTGGAAACTG + KKKKKKKKKKJKKKKKKKKKJKKK=I?IKHKIJKKKKIJJJKDJKJKKKDE?JKKDKKKKKKKKAKKIKIGE@FGF@HJDEKKKJJHHGKGFF9K;KKJK?KCJFHKKJJHKEIKKJK:JJ5HK>JKIKI?KKK@IKHKKJJJKKDIFFDD>DHK?IAEEKJJKJBIBJFJKJCDIIGJFIKKK>II9JKHEHKFKJKGJHD795KJKJKKEHJKAJJHHIJ@KFDJHCKE=IKKE@EKEKGICJ=KHK7IJE(DIGFK>FBKKKFJFIDIKJJIGJHHJ:EK?JJKFBIJJIJIJKKKGEFKKGEKKIKDJFGD>FFHKKAK@F2HIDKGC:JK4IHA>JIKGKKFKKKKKKGKKKKEEJ3KDJ?JJJKFJKKKBJKEHIKJIKJG>JIIG?G;FHIJCIJJHKJFJ>KEKJ@DCB:GJJEDJDIJJKJFIHKEJJIJKFHHGJ?JA,=IJK?HEJK6GJHEGIKHFGEJJIKJCGBEJI*CHK:JJHKBEJEIIJKDKI=JH>HKK?;CGEJKIKHGKFCEHJII5HKKI3H@KE@KHCICKJKIKKKJKBKACCFK?HGHDH:BI?JEBBJFKGKK3JIK6GKKJJJHH5K=AKEIIGJ-JKDIKJK=KJKGDEKI/JJIC?IKBKJJKK;>EHG?HDJJJKKJJAK:KKFKCKKJKKK>K8JJKKJJ?CK>KKJEAKGJE*,?KJKKK>JJDKJKKIJIJKKJ/>HK;KKC:KK>IJJKKIKKEKGKIK6HKKJKGJ-JKDJIJBKDKIJJ8JJFKKEJKJCHKK7KKKGKKK:KKKIJKKKKKKFKKJKJJKJKKAHKKKEGGD+IKKHKKKHKKKKADKK,KKKJ=JJKFK>HKKIJIKKK?KIK@KIKEG>CJKKJKI=KEJJKKIH1JIKJKKK@KKJKKHIGIKKKK9HKJKBKJKJ9>AKGG@@IKK@KKJJHKJKKKKKK4KKK9HKJKKJ3KAHKIKIKKKKEK=FKKHKKKDKJJKIKKKH6DGJIKKGKKKKKJKJKKJGKHKKBKJIIKKEKKKKJGJKEKGKKKKHFKDKKKJJIJKJHJKKFKGKKKKKJFKGIJKHJJKGEIKKIKKJIHKKJDKIJJKFJGJKKIKKKJKAKHKJJKKKKKHKK=JFIDKKKKKKJIKKHKKJHKJKJKFI:KKKJKJHKJJJKKHJKKK-JJKAKJKCHKKKKKKKKJKKKKGKKJCHFKEJJKJIK@KKKK@KK@KKKKKHKKKKKKKKCKHJK?JKKKKK;JIKJIKKKKJHKAFJFFHKKKKKEJKKKKKIIKKEKK@KKK6KKGKGKJJKJKJG>@KKKJKKKABKJ@JKKJJJJKKKKKCKBKKKHKJKKKKIKKKKFKKJJFKHKKKKKGKKKDGKKJKJJKKK/KJKJJJKKK9KJK?KKKKJKKKKKJKKKKKHGKKGKKIKKKKJHKKKKJJKJKKJGKKJKKIJKKKKKKKKKKKKKJJJJKKKGKJHIJJJKJFGJ2HKKIKKKKKKK>KKCGIKKCGKKEHEJKKEJKKKKJKKKIIJJHBKKKJKKKIKKKIJKEKIJKKKAJKBKKKHKKKKJKHKKJKKJKJKKHGIJIJKKKKIK?BIFKK6HK>K5KKKKKKKJI>FEJJJKGKK7JJGJKKJKKGFJJJKK7KKKFHGKKKFK=GKHKKDKKJJJJIKJKIHKEKKKGIKKGIKFKKEKJKKJKKKFKJJAKJCKKJKGKEKKGKJIIJKKKKKIKFKIKKJKKEJIKKDFJKKKJKGIKJIFKKJIHIIIKEKCGJK.GHKIKKJKK@JGG3IBIKKJKD@EKKFK?JJJKJJ9GKK7KBKKHKKIKIKKJIKJBHIKK@KDIAKKFHDEIBKJJKKKEKFDJHKBIGKJHIJFK @rCer/739/1583_57_CCS ATGGGGAGACCCGCGTGTGGCGCAGGCAAGGACCCTCAAAATAAACAGCCTCTACCTTGCGAGCCGTCTTCCCCAGGCCTGCGTCCGAGTCTCCGCCGCTGCGGGTCCGCTCCGACGCGGAAGATCTGACTGCAGCCATGAGCAGCAATGAGTGCTTCAAGTGTGGACGATCTGGCCACTGGGCCGGGAATGTCCTACTGGTGGAGGCCGTGGTCGTGGAATGAGAAGCCGTGGCAGAGGTTTCCAGTTTGTTTCCTCATCTCTTCCAGACATCTGTTATCGCTGTGGTGAGTCTGGTCATCTTGCCAAGGATTGTGATCTTCAGGAGGATGAAGCCTGCTATAACTGCGGTAGAGGTGGCCACATTGCCAAGGACTGCAAGGAGCCCAAGAGAGAGCGAGAGCAATGCTGCTACAACTGTGGCAAACCAGGCCATCTGGCTCGTGACTGCGACCATGCAGATGAGCAGAAGTGCTATTCTTGTGGAGAATTCGGACACATTCAAAAAGACTGCACCAAAGTGAAGTGCTATAGGTGTGGTGAAACTGGTCATGTAGCCATCAACTGCAGCAAGACAAGTGAAGTCAACTGTTACCGCTGTGGCGAGTCAGGGCACCTTGCACGGGAATGCACAATTGAGGCTACAGCCTAATTATTTTCCTTTGTCGCCCTCCTTTTTCTGATTGATGGTTGTATTATTTTCTCTGAATCCTCTTCACTGGCCAAAGGTTGGCAGATAGAGGCAACTCCCAGGCCAGTGAGCTTTACTTGCCGTGTAAAAGGAGGAAAGGGGTGGAAAAAACCGACTTTCTGCATTTAACTACAAAAAAAAGTTTATGTTTAGTTTGGTAGAGGTGTTATGTATAATGCTTTGTTAAAGAACCCCCTTTCCGTGCCACTGGTGAATAGGGATTGATGAATGGGAAGAGTTGAGTCAGACCAGTAAGCCCGTCCTGGGTTTGTTGAACATGTTCCCATGTAGGAGGTAAAACCAATTCTGGAAGTGTCTATGAACTTCCATAAATAACTTTAATTTTAGTATAATGATGGCCTTGGATTGTCTGACCTCAGTAGCTATTAAATAACATCAAGTAACATCTGTATCAGGCCCTACATAGAACATACAGTTCAGTGGGAGTAAACAAAAAGATAAACATGCGTGTTAATGGCTGTTCGAGAGAAATCGGAATAAAAGCCTAAACAGGAACAACTTCATCACAGTGTTGATGTTGGACACATAGATGGTGATGGCAAAGGTTTAGAACACATTTTTTTTCAAAGACTAAATCTAAAACCCAGAGTAAACATCAATGCTCAGAGTTAGCATAATTTGGAGCTATTCAGGAATTGCAGAGAAATGCATTTTCACAGAAATCAAGATGTTATTTTTGTATACTATATCACTTAGACAACTGTGTTTCATTTGCTGTAATCAGTTTTTAAAAGTCAGATGGAAAGAGCAACTGAAGTCCTAGAATATAGAAATGTAATTTTAAACTATTCCAATAAAGCTGGAGGAGGAAGGG + KKKJF&KJK>H.KKKKKKKEKKKKKKKKKKKKKK2KKKKKCKKKIKKKKHKJKKKJKJKKKKKKCKKKKKKKK=KKGKJKKKKJKKKIJIFJFHKKJIKKJJJG79KKKKKKHKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKIKKFKKKKKKKKKKKKKKKKKKK4CKKKKGK(?DIKKJKKBKKEK?JKKEKKK>:0KHJKKKKKKKKKKKEKKKKKKKK)KKKKKK=KKKKKKKKJKKKKKAKKKKGKKKKJKKKKKKKKJKKKKKKKKKJKKKKKKKJK>KK@KFKKJKKKKKKEKKKKKKKKKHKKKKIKKGKGJGFKK1KIKKKKKJBKK6IKHKHKKKKGKKGKFKKKKKKKKIKKKKKKJK>KCKCKKKKKKKKKKKKKKKKKKK>KKJKKKKKKKKKHKKJKCKKKKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKJJKKKIKIHGJJKFJKJKKKKKKKGKKHKBKJKKKKKJFJKK/J@KKKKKKKKKKKFKKKKKKC=K8@KJKKIKJKKKJ6EKKKKKKKKKKKKKKEKKHKKKKKKKKHKKKKKKKKKKKKKKHKKKKKKH8:HGKKKKKKKKKKKKKJKGKKKKKKKKKIKKKKJKJKKKKKKKKKJKKKKKKKKKKGKKKKJJKKKKKKJKKKHKIKKKKKKJKKKJKKKIKJKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKFJKKKKKKKJKKKKKKKKJKJKJKGKKKKKKHKKKKKKKKKKK&KKKKKCKKKKK=KKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKHKKKKKKJKKKCKKDKKI=KKKKKKKKKKKKKKIKKKKKKKKHKKKKKKK@KKIKGJKKKHKKGKKKKKKKKGK>KKAKKKKKKKKKKKKKKK*KKK;KKKKKKKKKKKKK4KKFKKKKKKKIKKKKKCKKKJKKKKKKKJKKKKKKKKFKKKKKKKKEKKDKKKKKKKKKKKKKJKKKKKKKJKKKKKKKKKKKHKKKKKKKKKKK.KIJJHHKGK0KKKIKKKKJKKJKKKKKKKKKKKKJKKKKKKKKKKDJKKK9KKKDKKKKKKKK=KKCKKKKKKKIKKKKKKKKKIKKDKKKKJKKKKKKKKKKKKKKK;KKKKKKKBBKKKKKKKKKKK=KKKAKKKKKKKKKKHKKKKKKKKKKIKKKK>KKKKKJKKKKKKKKKKKKKKEKKKKKKKKKKKKEK>KKKKKKKKKIKKKKKKKKKKKKKK-KKKKKKK+KKKKKKKKIKKKKKKKCKKEKKKKKKHKKKKKKKKKCKKKKKKKKKKK$'GKKKKKKKKKKKKJKKKHKKKKKKKKKKKKKKK2KIC%KKKKKKKKKKKKKKEKKKK-KI1KKJKKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKK*KKKJKKKKKKKKKKKKKKKJKKKKKKK5KKEKKKKKKKKKK)KKAKKKKKKKKKKKK8KKKKKKK7KKKKKKKKKKJKK,KK6KKKKKKKKKKKKKKKKKKDKKJKJKKKKKKK4KKKK.KKKKKKKKKJKKKKKKK4KKJKKK0KKKKKK9KKKEKKKKKKKKKJJKJKKHKKKKKKEKKKKKKKKKKKKKKKKKKKKFJKKKKKKKKKKKKK)KKKKKJ%JJKJK:KKKDKKKKK:KKKKKJKK2KKKKKKKKKKKKJ?KKKKK2KKCKKKKKK?KKHKKKKKKKDKKKKKJKKKKKKKKKKKKKKKKKKKKKKJKK/KIKKKFKJCK*KK+KKKKKKKKGKKKKKKKKKKKKKK;KKKK?KKKJK2KKKKKKKKKKKKKKKKKKKKKKJKHKKKKKKKKKKKKKKBKKKKKKKK0KKKKKKJ8FKKKKJKKKKKKKG7KKKKKKJKKK4K;KKKKKAKK'KKKKKKKKKHKKKKKIKKKKJKCKKKKKKKKKKKKKKHKKKAKKKKKKKKKKGKKIKKKKFKK?KKKKK5KKKKKKJKKKKKHKKKKKKKJK@=KK8KKKKKKKKJKKKKKKKKKKKKKKKKKKKKKIKKKKKBKKKKJK*KKKKKKKKHIKJGKBKKKJKKKKKKKK+KKKKKKJKJ,KKKKKK7KKKGKKKKKKKKKKJKDKKJKKKKKK6KKKKKKJK?KKKKKKKK4KKKKKKFIKKKK&JKKKKK:KKKKKK3KKKEKKKIKKKKKKKIKKKKKK5KKKKK9KK;KKKAK)KKKKKKJKKIKKKKKKKK;KKKKAKKK3KJKKBKKKKKKKKKKKKEKKKK%KKKKIKK4KIKKKKKKKKHKKKKBKKKKKKKK:KKIKKKKKKKKKKKKKKKJKJKKKJKKKKKK,KKKKKKKKFCKKKKKKKKKKKKKKKKJKIKKKKKKKKJKKKKK9KKKKIKKKKKKKKKKKHKKCKKKKKHKKKKKK @rCer/742/1157_59_CCS CCAAGCAGAAGAAAGATTTGACAACTTTCTTAGAAAGTCAGAAGAAGCAGTATAAGATTTGTAAGGAAAAAAATAAAAGAGGAAATGAATGAGGACCACAGCACACCCAAGAAAGAGAAGCAAGAGCGGATCTCCCAAACATAAAGAGACTTGCAGCACACGCAGGCTGAAGAGGAAGCCACCTTCTCACTCAACAGAGACTGTACTACGACAAAAATTGTCGTTTCTTCAAGCGGAAAATAATGATCAAGCGGCACGAGTGGAGCAGCAGAACATTCGGGAGGAACTAAATAAAAGAGGACCAGAAGGAGATGGAGCATGCCATGCTAATCCGGCACGAACGAGTCGACCCGAGAGCTAGAGTACAGGCAGCCTGCACACGTTACAGAAGCTACGCATGGATCTGATCCGTTTACAGCACCAGACTGAACTAGAAAACCAGCTGAGTACAATAAGAGGCGAGAAAGGGAACTGCACAGAAAGCATGTCATGGAACTTCGGCAACAGCCAAAAAACTTAAAGGCCATGGAAATGCAAATTAAAAAACAGTTTCAGGACACTTGCAAAGTACAGACCAAACAGTATAAAGCACTCAAGAATCACCAGTTGGAAGTTACTCCAAAGAAATGAGCACAAAACAATCTTAAAGACACTGAAAGATGAGCAGACAAGAAAACTTGCCATTTGGCAGAGCAGTATGAACAGAGTATAAATGAAATGATGGCCTCTCAAGCGTTACGGCTAGATGAGGCTCAAGAAGCAGAATGCCAGCCTTGAGGCTACAGCTCCAGCAGGAAATGGAGCTGCTTCAACGCCTACCAGAGCAAAATCAAGATGCAAACAGAGGCACAACATGAACGTGAGCTCCAGAAAGCTAGAGCAGAGGGTGTCTCTGCGCAGAGCACATCTTGAGCAGAAGATTGAAGAGGAGCTGGCTGCCTTCAGAAGGAACGCAGCGAGAGAATAAAGAACCTATTGGAAAGGCAAGAGCGAGAGATTGAAACTTTGACATGGAGAGCCTCGAATGGGATTTGGGAATTTGGTTACATTAGATTTTTCCTAAGGAGGACTATAGATGAGATAAATTTTTTGCCATTT + ,)+',)-))+(*-+),-+&%(,-$#$)#+.--'+,#--***$$.)%(++()1(+-,'-.)'+)))*/-*(&+&+,+*&00)*)&$&((&*++')-2111(*'%*'((&/*),)&(.)/$**'&*&)),.0/0(%$$)0(0)'1,,&),%.,*&(*+*'),,..-''0*%+%,-+#'(&%#)*'11/.$'&').%.,/*-0(&))%)($*(&(,/01,3(,/.+,0&,))32(+5.0/4)%#-*+-,&+.),-..1)+''$.0/2121.,)'**-,*&*/#**+&/*+(+*%)-/2'1550/2$344,3/4030-))41+%,'''$&+(-)**),'$%-,+'-+*,*'#*--).)*+*)$$-,0,0/0)%1.,,((/(,)-.0021,*.''%/0/./*/),(-,-.)))14-+3-13.0112'(-&$#)-,4/++,11'*-,&/.).02+(+*.1,/35-0/,/550553515522345.5/-02--.'4313*0,0-',536240/*4020/.'#&1-/5.0)-/445-.64550,1)-'4650/+0*%&)&100)-0.,)$%0554/010/*33050,*)*'+((0+.1-,.-/'-//0/(*(0451620.0-,+%#-%*0&/)-$++(*0*/322$+)%+.5.,-)(,-24(-+/&-32-)-63-((.(//+-%,0(01,)/,%*-('().,-.3-.22.//',*,,&-,*,424)&/*,&$(-0(/6321100---,*5401&-&-,00*.2.513120461(-,*)#-*4'55110,..+,-$+-/)4//&13&01(+/10-+'%*+,/-+.11')*'*0+,++'.'/())+-0+/(.,01-0/'.*&**))/,,*&$..,0+*.*(/*///3/0.(.03+*)2/.1/556/45.4+4/.2352*(/54-)*%&+'+)//.-2+++',-/10*(5*635634.1(+#&+4151-(*13*/.12146/-+314,/(35*2/35/.15*025520)'*050*&)&-/0343*//-00*'#2/+-)()//-./*&-).3+2220.+-50030..+2&51/1+*%,1+031.-&,(.303+((('/0)/0*/4/131( @rCer/743/1807_59_CCS ATGGGGAAACAAGGCCGTGGGCTGCAGGAGCGGGGCGGACGGCTGCAAGAGGAGCCGGCCAGACCCGGATCTCTTCCCCGCCGTGCTCCGGTCCCGGGCCCGCGCGCCGCCGCCTGGCTCCGCTCGCGGCCCCGCTGTCTGCAGGCGTGCCCCGGCGGCGGCGGAGAGCCGTCCTCGCCGAGCAGGCTGGTAAACGCGAGCGCAGGCGGCAAAGAGGCCTTAACGCCGTCCCTTTTGCCGCCGCCTTCTTTTTGCCGCGCGCCACTGTGCATTTCTTCTCATTTTCCTTTGTTTCTTTGGCCCCTCGCGGGTGTGGGCATTCCTGGTGAGCAAAAAGTGCAGCCTCAAGATGGCTGATGGCAACGAGGATATGCGGGCGGACGACTTGCCGGGGCCAGCCTTCGAGAGCTATGAGTCCATGGAGCTCGCCTGCCCGCCGAGCGCAGCGGCCACGTAGCGTCAGCGACGGGCGCCACATGTTCGTCTGGGGCGGCTACAAGAGTAATCAAGTCAGAGGATTATATGACTTTATCTGCCTAGAGAAGAACTATGGATCTACAACATGGAGACTGGAAGATGGAAAAAAATCAACACTGAAGGTGATGTTCCTCCTTCTATGTCAGGAAGCTGTGCTGTGTGTGTAGACAGGGTGCTGTACTTGTTTGGAGGACACCATTCAAGAGGCAATACCAATAAGTTCTACATGCTGGATTCAAGGTCTACAGACAGAGTGTTACAATGGGAAAGAATTGATTGCCAAGGAATTCCTCCATCATCAAAAGGACAAACTTGGAGTCTGGGTATATAAAAACAAGTTAATATTTTTTGGAGGGTATGGATATTTGCCTGAAGATAAAGTATTGGGAACTTTTGAATTTGATGAAACATCTTTTTGGAATTCAAGTCATCCAAGAGGATGGAATGATCATGTACATATTTTAGATACTGAAACATTTACCTGGAGCCAGCCTATAACTACTTGGTAAAACACCTTCACCTCGTGCTGCCCATGCCTGTGCAACTGTCGGAAATAGAGGCTTTGTGTTTGGAGGCAGATATCGAGATGCTAGAATGAATGATCTTCACTATCTTAATCTGGATACATGGGAGTGGAATGAATTAATTCCACAAGGCATATGCCCAGTTGGCCGATCTTGGCACTCACTAACACCAGTTTCTTCAGATCATCTTTTTCTCTTTGGAGGATTTACCACTGATAAACAGCCACTAAGTGATGCCTGGACTACTGCATCAGTAAAAATGAATGGATACAATTTAATCATCCATATACTGAAAAACCAAGGTTATGGCACACAGCTTGTGCCAGTGATGAAGGAGAAGTAATTGTTTTTGGTGGATGTGCAACAACCTGCTTGTCCATCACAGAGCTGCACACAGTAATGAAATACTAATATTTCAGTTCAACCAAAATCTCTGTACGGCTAAGCTTAGAAGCAGTCATTTGCTTTAAAGAAATGTTAGCCAACTCATGGAACTGCCTTCCAAAACACTTACTTCACAGTGTTAATCAGAGGTTTGGTAGTAACAACACTTCTGGATCTTAACGCTTCATAAATAATGCCTATGATCACCTTGCATGGACAGCAATCCTGTAAAACATCACAGAGTGGCATCATTTGTATAATTATATGCATTGTTGTAGTTTGCAGCTTTTGGTTTTAATGTGCATGTGAATGGCTAGAGAACCTATTTTTGTGTCTATAAAGTTTACAATAAATGTATTTAAC 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@rCer/744/1808_56_CCS ATGGGGCTTTTTCGCAACGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCCCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCCACCACTACTGGCCATCTGATCTACAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCTTGGATAAACTGAAAGCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAAATTTGAGACCAGCAAGTATTATGTGACTATTCATTGATAGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGTGTGAAACAACAATTGTTGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTCAAGGAAGTCAGCACTTACATAAGAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGAGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTTGGTGGTTATTGGTTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATATCCTGAACCATCCAGGCCAAATAAGTGCTGGCTATGCCCCTGTGTTGGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCTGTTCTGGTAAAAAACTGGAAAGATGGCCCTAAATTCTTGAAGTCTGTGGTGATGCTGCCATTGTTGATATGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTAAATCAGTACTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGGAATTTTGAGACCCATTAAAAAAAGTTT 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..012%0/154+56..*2.$.1*.*$,-'20320-2232454182&+1/'/-)'57-/247'57,4:31074,5,*/*//.$11.&*.0-,821,3.,3/617.5;6:16.+22250/9.999476267,1&292.333647/9-81234.+-0+43-)**%((#)(.-498896242543834726;93:/5805536/6888,-1457:92277136929:1626314592557:483401%455066370,//5343()-625/'&+(+)5403,.-,%-+-.687185/,-,&/2.(5'+66,97+433422.',1.3629,--///3,1*-%0,,+41.%-+,3.0653551/41,//0'&*+4-3//&,,)323.(((.4+51(2544*.)11.00/1114,320'./*')(,)141+.*4.412'13-00-.,%.2)00022/11,0+,.-1+'221&(()20+'/0/+0/-)1),*.+//3/06---)*130+(4-20/3*41,#0)1/36,5.*00%.14323+3-4-416./(-0/,,)3,-.2,51/635340.0.,-,+',.)1+'2+-0(.)1-2*1-+,'2432'/+%#30&)22$-..../004/*-1332-,&(*,$(,-0/&4315/4./-)/*4*//.$,+35)1)4661,)&*)14/).1&1/11.2/0**1+*/(',2.2,(,(0.,,-4*-'.-1---,++,3(*.%$-0(--2-'.30)1(%%(*($'(%,'/16..+,0303)/3542..,(+'++(.*..-'/0,*&.*+,20-+/2+3'/3(/.200'&*-2*,-/3/-5./(-(44.-/%+()*+*&+/)0-,%42+22*64.-1+403'/..*0&**,').'-)'(1,,.0+)+,$*.-,.-+./.-/0-,3/0/-/.//305243)*+')+-2,1+)),.-2.//3.+0262*0/550.14-1(&/,1..-(+*.)/0+/.)2*.5),*016114/-2*32200%0*,(+-,0()-2*0-.0/54*3%/,33353/*/+*&-/-'22+,,(1,50-00-.*22(&).$/0)--+/,+/+&)/*,..*2-(+*(+/00(%,-&$&/-)($(-.'-*.0.-/-55/01-0')&$*.(.**+,*+*'$(-,+,',)&/1'&+"'0..0+(-))$)*,)%$%,,&.115661..-*.014,,),0-)0*.'*,/,0%,5/-/*&")-*0,3-)*-+,+#((.'.*%)0+64/--%55,4&*1'024052+&(+&*.//-,+',''40-3+/1/&-%)++&%-+,*('',%/3/.'/0,),+.).'0&110('%%+(0211.*),%).&345364+*-)(++-3205/.1005/'++*0(-61326(.*+*/-())-0-,,$(550010.33*.011.+&1432+%-5/**01/2)3225,1/*/45345*10/0(5311155)2%566646/3%)-),.-+4-*0&1/0)+0*(,/0$(+*+,&+$,2(25/-**+..410+1*10.(+46+'256624642/0./+61-&0.)&3/.,,)32/.23666-3/5454504,51-/2)..+11-/6550)/1'*)64/034+4033*2-1231..466/3541.5222362/3554)566164,.,(*/02,221133*4-011.6/.16626/33$215/3),334$(*12)50-/.,35*4-2*4334*20)-.,3-+)%4/45626653,3+-5.-1100-&/0., @rCer/747/942_58_CCS GGCACTGAAACTTCCCCCAAATCTGGTGGACCTAGAGTCAGATAAGTCTGCTTTTGTACCTGCTGGGCCCCAGTTGGGCAGTTAGTCACATTTTTTGTCTCTGTTCCCTCTCATTTGAAAATGTAAAATAAAACCAAAAATAGATAACTTCTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATGATTGTTCTAATTAGGTAAATAGAAGTCCTTACATTTGTGTTACAAGAATTCCCCCCACAACATCCTTTATGACTTAAGTTCAATGACAGTGTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTCACGGATCTTGTGTCCAGGGACATGGGGTGACGTGCCTCGTATGTGTTAGAGGGTGGAACGGATGTGCTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTGGATTCGCATCCCCACCCAGGGCCTGCTTTTACTAACCGTTCTGCCCTAGCTTGGTTCAAGGCGGTCATCTAACTGACTTGATCAAGTGGAATTGGGATGTATTTGATACACTTTTGCCTAACAGCATGGAAAAGGGTTTTCCTTTCCCTGCAAGCTACATCCTGCTACTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAAAGTTTTCAGAAAAATGAGGATTGTTTTCCTTGTATCACTTTTTATCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTTCCAAAGTCAGCAACTCTCCTGTAGGTTCATTATTGAATGTGCTGTAAATGAAGTATTTTGCAATTAAAATGAGGTTTGCTCAC + >(<:A>@BB80=F?GFEA9AE5C@E@DIC?68DH?ICGFGDCBE2EEEGBEHFB@F7FKJ>GEJCKKHGDGKEIJIIHHHJJJJH;JIIJHFJKDKKIFGBHGFI%GHIJ>FKEIKE1?IKKJKKHKIFAIGKCIJ2JHKFKFIJJGH=IIIIJFGIJIFKJIIBHJJ@JCEGDJKKJIFFKEJGKHJ>BKEIB:EKHJEJJHEJKAG'8GDJH,IHHFJ?BKEKF9HHKJIJ8I@FIFJKHJGFK@IJKJJKIHG4KJIKGHKI?FCHKJI?EHIHD@I1HIDFG4KDKJEBGG5KH:GKHFIAH9HGJIKKKJHCFJHFHK8JJJBIBFHGG5@KFJHBAIKJ8>KDKKIHJGE;IJG:>HAJDCIJHKKJJKKJH.>@IFFHCIDD@@HFBKJJIHGHJJIEJGJCEJHHHJFJKEJ;JHJEJJCHDG9IHIH;5HICHEIHGECA@?@A=BA.>6@DAEE=;?DA>BEB8DB9@==D8BF?>D2BB=>8@>65=@1E:BF@>D6A?><>.DD=GCDEE=7DGF=<@A@@4EEFEACGB6DDD>5-@79@ACF>FFB0??><7%;EFE4G?7@:3>A?998<::>A5AA83B=>=>B5DABC@>A6B>;A?,B>76:9>C<,;ED=9F3>B2<9<<=A>@=>>87AA:7C5>C@BF;?B;>AD>DA>FGF;C>A1EEC@5B@B>=CDFE;@EBFG=8@B=4:?6:>@8E$;9-2CC3B7BFD/A?:DAFCDDB?AD8BBD>E:>;BBDBGCB7GDDAA4>;B7DCC>@EEA(CDBCEE97E?FF9GFCA;EFB?>=9DCGF>A?6%4076?)8@=<@/@>92=6F=<>B@7A=@;;66699(?)A<;3;68=@?9=C@+7BB????BC>A6?==B==?;4A@A<;518>@A;8@<<6;@;,<@=?:@=.=5&(355>?>1>:95:3:7ACE@>=<2AD?D@=@A8:,A<>BE>>C=BACCD28F>FF@<0F=0A3A2=>&>??BE>D9D?<>C6;>9GD?,@B7<;B2B4BA<>C2E@B:??@B=:@CBAEBEFB'>=B9:+:CFDD?3>BC;@FEEDG)=99@=:E?=CDBD;9CCA;<:ED;2D0?6BCD@>;@DBA32?CEGFABFAE>EE8EDDBBG3D@EFE?*E/?>/=C@CAE7B5@8:+??=A*:>?GA)E?;:>7A=E??.@==0DCFB=AB9@@A=6=<6;@FF8B9CB?C?AABBBDB>:5?=?=;&>A>BB>EB.$5894>?A@85:)=4B<DB<:<7@4DE+AAB:?8E<59CAA3A1?8<=>C>/A@)DC>3@:='B<@79-B:6C@EB<:BBE=CBC>C>=.@;DEBGA:G@:2@C@=CG@G1@A@BC7B=@FA?E@G6EDD@?DB?=E>EC8DCCBBGFBDA?>D@1BF1FEEB;?CBACCACB90FF?GC?B>6E=75D@.@9?AFFFCD@AD?FDED;FF>2@??CA@A+A>;@A7;+;<6:4>;@@>E=9@<7C:CDDFE?D?>ED=G?@ABEFBEC@B7E?BF7E&=>5#1B=5@ABEE6E%AEC>AEGFD8?>B>GD2ADGDBCA7/9BBBB5B9ECEBDA?=77=E?C??B*>=C/8E=;C.=?AB9+A?>?ECBBCE7@:=?D>'DD@ECGE78:@AB;E:CFC7CF:?<7AFFCAFC9A=:<:;9AEC9B8C/CAABCDDDCBF>::.5>-E@?'>=9G)@@A>>?E@BC46C<<@9EF@D6>@@BC?#8%A@A@E=DFE@BBCEAA4DFEEEFAA@FBB9E;CD;BCA@@D9D@F;?BGBAFE?ECF=E>>C*C8?A?B?GFEF?9@697:BG?G(CC@>8,CDE:A>:BA7 @rCer/753/2546_55_CCS ATGGGGCCTGCCGCCGGAATTCTGGAGCCAAGGAGGCCCGGGGGCGGTCTGGCGGCGCCGGCGATGGGGCATAAAACCACTGGCCACCTGCTGGGCTGCTCCTGCGTGCGCTGCCGTCCCAGATCCACCGTGCCTCTGCGGCCCGAGTGCCCGGAGTCCCCGCCTGTGTCGTTTCTGTCGCCGTCCCGTCTCCTGCCAGGCGCGGAGCCCTGCGAGCCGCTGGTGGGCCCCAGGCGCGCAGACATGGCGGCCCCACCAAAGCGCGCTGGCTGCCGCGGCGCTGGGCGTGCGGGGCTGCTGTGCGCGGTGCTGGGCGCTGTCATGATCGTGATGGTGCCCTCGCTCATCAAGCAGCAGGTCCTCAAGAACGTGCGCATCGACCCAGCAGCCTGTCCTTTAACATGTGGAAGGAGATCCCAATCCCCTCTATCTCTCCGTCTATTCTTTAACGTCATGAACCCCAGCGAATCCTGAGGGAGAGAAGCCGCAGGTGCAGGAGCGCGGGCCCTACGTGTACAGGGAGTTCAGGCACAAGACCAACATCACCTTCAACAACAATGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAGTTCGAGCCCTCCAAGTCCCACGGCTCGGAGAGTGACTACATCGTCATGCCCAACATCCTGGTCTTGGGTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAAGCTCATCATGACCTTGGCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGGGAGATCATGTGGGCTACCAGGACCCCCTTGTGAACCTCATCAACAAGTACTTTCCAGGCATGTTCCCCTTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTCTTCACGGTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTGGAACGGGCTGAGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATGGAACTGCTGGGCAAATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCTACAGCCCTGAGGCCTGCCGGTCCATGAAGCTAATGTACAAGGAGCCAGGGGTGTTTGAAGGCATCCCCACCTATCGCTTCGTGCTCCCAAAACCCTGTTTGCCAATGGGTCCATCTACCCACCCAACGAAGGCTTCTGCCGTGCCTGGAGTCTGGAATTCAGAACGTCAGCACCTGCAGGTTCAGTGCCCCCTTGTTCTCTCCCATCCTCACTTCCTCAACGCGGACCCAGTCCTGGCAGAAGCGGTGACTGGCCTGCACCCTAACCAGGAGGCACACTCCTTGTTCCTGGACATCCACCCGGTCACAGGAATCCCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTACATGAAATCTATCGCAGGCATTGGACAAACTGGAAGATTGAGCCGGTGGTCCTGCCACTGCTTTGGTTTGCAGAGAGCGGGGCATGGAGGGGAGACGCTTCACACATTCTACACCCAGCTGGTGTTGATGCCCAAGGTGATGCACTATGCCCAGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTCATCTGCCAAATCCGGAGCAAAGGTCCTGAGGACACCATGAGCCAGCCAGGCCTGGCCGCTGGGCCTGACCGGCCCCCTAGCCCCTACACCCCACTTCTCCCGGACTCTCCCAGCGGACAGCCCCCAGCCCCACAGCCTGAACCTCCCAGCTGCCATGTGCCTGTTGCATACATGCATGCAGGCCTGTGCAGACACTCAGGGACGGAGCTGCTGCTGAAGGGACTTGCAGGGAGAGGCTCGTCGACAAGCACTGTTCTGGAACCTTCTCTCCACGTGGCCACAGGCCTGACCACAGGGGCTGTGGATACTGTGTCCCCTTCCTTGGGTGAGCCTGGCCTGTCCCATTCAGCCATTGGGCCCAGGCTTCCTCCCCTTCAGGGTGAAACACTGCAGTCCCGGCGTAGTGACTCCCCAGGCAGGACTGGCCAGGCTGGGAGTGCTGGCTTCCTGTGCCAAATAGCTGCCAGGCCAGGCAAAGCGCCTTTACACAGGCCTCAGAAAACATCGGGTGAGCACGAGATGCCCCGTGCGGCTGCCCGAGGCTCCCGCCCACCCTGGCCGGACCTTGATCTCCCCGAAGTCTTCACAGGCACTGCATCAGGGTGTCTGCTGCCCGTTTCCTCCAGCCTAAACTGACATCATCCTACGGACTGAGCCGGCCACTCCCTGGCCGAAGTGGCAGCAGGCTGTGCCCCCGAGCTGCCCCCACCCCTCACAGGGCCCTCAGATTTTAGGTGCCAGGCTGAGGTGAAGAGGCCTTGGGCCCTGCCTCCCGCACGCTCCTGGACCCTGGGGCCAGCCTGTGACCCTTTTCTACTGGAAATGAGTTTTATCATCTTTGAAAAATAATTCACTATTGAAGTAATAAACCTTTAAAAAAAT 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1031-(/,435,.832-0+836537806):17513)87.0/),+12,*-230496:6;7;61.2,363/220133+-+551402-,3346,45-&04.1423972409713/26528::+4350676857794%52855910)'1/2044603.*5220.+0/'+/))).21.($(24113-,+..(,.-/52+*6/.(*++,*).,.2-*,,/.)222002*044.334(0,$,12.*,)22,++$-3.2*)(/((36)+34--142+3./1-,1.)+$(033.&*$$$()1(/&.50-536413-0,.426.1/2131*-*61431,4-)4*012.%-/63/1/.+,'.1**1.613.-553120#02215662.%/014%2-2+06/44212'0.0%)-.0,0--*-(,01)'(#))*)*(##..002*+,*&,)1-$%+**2/5(/5345,.,)'#(%$+)*##,3(-&##)+55403-.3,2744//342:30.,)/(,)24/72+),(402.()%2///.-,041/6237-*5/31-/44101.+,*1-063788265+0,2.2./(4244454-//%.%(.(0-317456962417)/510/422/+0-/)()/.+.222,0'23-/-*251/2(.513603655865,414)/2+9185.&,,*6352440.2/0)0:3114$1/-201+4.*-'32450/1)4984240:574:5542%42.*2,/)//:7:415313-34464/55..844265//-(--'+-3-*$3/$,0,111/'10336+6-/-421-(2+1047-0-(3/25:35:993+/&8/416::14*27168910$37164464.%.536:96438133007'524-0+021.*,%-0/50/72/(6.735332,,1&58.999303656552121/5&3558056;/00976443;539:0733232801)1-4849158/0127-/,447421..+4.1/757866.597625/8242/(011*-64259484807'35,48768.7448::481/1364522...24+32657:451/./(/)655;934662:2562,.*223$*--,122+1.-./((#.0%3-04920.*&,+0,0'1(153,2$323-)-05$*6*353-16736.046,-44.%/'-+,*251)1354922255-11/3$85:6-56/9.2.$5,:30378776972663.'3,5480*48'977:9939:25..2#/3+214%214-2/722/902350,/-,.33))7146*125::62+,))$72443872679986:31/.5,4;822220*482;92370&,&,3*6457839397=27:8+8;1;398?;195:>670489823738813><>;>89;29=68,>:>=:;::6<5:79;6'44)>=39<815=<+547'705->858:7.5073/14.0,..,*/83+4+4-97573+688-,/22+%&59551933'6646:;;79-53365-17=<;:<;?1>7-*38:554532277(194)798996:=::7?<75/68.<;9;7+<39:3174;965073,15617240>57886-.651%21085672657?=<4<975*2(6:990000/.6;,7>9588.=87(;;7>7?>396:;32;326954%29610(87695138;3?9<<97<;;::?;?8:5894306.27978>80<189>>;91?9;79<>;978;707;2<5);?9784.-.54289?74:262?99::==6<:;?;<6<;>><:=7/13:<5>=928;:?;?:91125171<:39755)=?>=76/53:61;9359<0=>;==9;;:9;8=777:<1=2?687=>.**;7=8:237,:65;>2:?==9/;45;:;9/9:*:6,02:7/5<'=48<686:<84,89909<3328:46::6<4;88<=:=0597761;7<=2:38767=2::89792-<35(493672*=;;=.<=53:483:1=:5::>???9=9;:81#%6+644.57762671/&4284=:58784-653'713/%894/847.4/-0&**5354/655/299:15628638272/55/886578426632(./5564+.69;358408+46468:83:621-9:9:465694305:6::6.539-8*;8:847:.87-949922-4/0.2,+/.24780.(-,%554.2473.2&2622'++-&.76+8:$52253465,4956//$*4*59922)9332874$8(2+9.,35)445242:4:4.26/67)31./32*6558':38384.585865&::9)1-48/4/55*41)68::-52797984&46167)53599:::652&0758970684&:488/999974(5 @rCer/754/25_1887_CCS ATGGGACCACGCAGCACTACAAGCCAGGTCACCCCAGCAGAGGAAAAGGATGGACACAGCCCCATGTCCAAAGGCCTAGTCAATGGACTCAAGGCAGGACCGATGGCCTTGAGTTCCAAGGGCGGCTCTGGTGCCCTGTATATGTGGATCTCGCCTACATCCCGAATCATTGCAGTGGCAAGACTGCTGACCTTGACTTCTTCCGTCGAGTGCGTGCATCCTACTATGTGGTCAGTGGGAATGACCCTGCCAATGGAGAGCCAAGCCGGGCTGTGCTGGATGCCCTGCTGGAGGGCAAGGCCCAGTGGGGGGAGAATCTTCAGGTGACTCTGATCCCTACTCATGACACGGAGGTGACTCGTGAGTGGTACCAACAAACTCACGAGCAGCAGCAGCAACTGAACGTCCTGGTCCTGGCTAGCAGCAGCACCGTGGTCATGCAGGATGAGTCCTTCCCTGCCTGCAAGATTGAGTTCTGAAAGAGCCGCCCTCCCTTCCCCAAGGATCCACTCCCCCAGCTCCTTTAGAGAATAGCTACTGCTGAGTCCTCTGGGGTTGAGGGACATGGGAGCTAGGGGGAGGGGAGGGAGATGTCTTGTTGTGGGGACTTGGGCTGGGCTAAGTGGGAGGGGTTGTCCCTCCCCGTCATCCATTCCTGAGAGGGGTCTCAAACCAAAGTTAACAGGGAGAGGATGGGGGAGGGGAAAAATTAGAATAAGATAGCATCTGATGCCTGAGAACCCTCTCCTAGCACTGTCAAATGCTGGTATTGAATGGGGACTGAGGATGGGTCTCAGAGAGCAACCTCCTCCCTCGTAGAGGGAGATTATATCCCCAACTCCAGGGACCTCTTTATCTCAATCTATTTATTTGGCATCCCGGGAAGGATTTCCAATAGTAATTTATGTGACCTGGGGGCAGGATACTGTCAGTGAGGTGCCCAGAGCTGCATCCTTTTCTCCATTTCCCATCCCCCATCTCCTCACCCACCAGGGTCTGAATTCTAGCAGGGGCCTGGGGTATCCCACTGCTACACTGTTCTGTTGCTTCCCTCAGTATCTGAATGTCTCAATTTAAAACTTGAAGCTCTTTAGACCAACAGACTGGTGAGAGGAGAAAGGAGCTTATCCCCCAGCCCCTGCTTTATACCATTCACATCCCAGGGCTGTGTCCAGACAGCACAAAAGGGCAAGGAGAGCCCAAGCCCCAATGCCAGAATTCTTTCAAACTCCCTGACTCTTTGAAGTTTTACTCACCCCGTTTCAATTATCCTGATCCCTTCTCATCCCCTGCTTGGCTTCTGTGCATGTGGTCATCTGCTGTGGCCTGGTGTGTAATGGGTTAAAAATAAGCCACTGCCTGACATCCCAACATTTGACACCCCAGCAATGTGTGACTCCCCCAACATTCCACTATGCCATCCTGCAGCTGAAATGGGAACACTGGCTGCCTCTCCAAACCTGCTCTTGGACAGAGGATCTGGGAGGTGGAGGCCAGGCCAGAGGACTTAGGGAAAATGAGAGGGAGGAAGGAAAAAGGGAGAAGAAGCTGAGCCATAGCTTAACTCCTACAGAGTGAAATGAAAACGGGCTGAAAATACCACCCCAGGAGAGGACCTCACCCCAAGCAAGCCAGTGAGCAGTCCTGCCAGACTACTGCCAGACTGAGAAACCCAGAAGCTGGTAGTCATGTGGGCTTACCTTCTCTGCCAAGCGACTGGGAAACCAAAATGAGTCCACCTTGTGTTCTTAGCTCCACCCTCCCCGCGCTGCTGTGCTCTGCTCCTCCCCACACTTCCCTGCTATAGTTCCCAGCTGCTGTAACGGAGCCACCTCCAACTCTAACAATAAACCCAGTTCATT 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E?1=D>>DA?A>2ABC:?AE=D?:BC5DDD>(AB>;>@=4@>D9@AC>A48>9=$<6=;B5=@;D>@C9?D@C@>>::=??>B>@@;>C<<@GA9EAC?>;;>:F7CC=D;@>=?:=D7EDDA=<*==;??<;C?CDC2GB>C3@@DCC;<<=@9B<;:;75<;>9A=?GEBB>:-B@?@A8DGEF@?B=9AADACGCCEFCF>A:@?A8@A@=A>D:B?@DAC3><3?@B?9>>??F:B@@B7B0F7>84BBDD?3CB:?:9=0>BD@A3+D;AC@>EDADB5:>CC7F59>49C???@CC:>B?<9DDDDCD3A=@1?BB?,;8AF4;?;=7@<>719CD<;FG?C4DDBBEDEAB>GA7+,;D=?>D6=DE6FD<655+AB@CCC@BB?C9BC>==B>A3/BEA3DD<1BAAA=B,D;>@B?4(BA4BBA+B@;;?<@6DE@>8CCB@;AA?@GGD4DA?9>D90B>7*8=@AFBBE;FBE:DG<@A7>7BCE>>:1.=A9A;DA==D9DEA;E@F@A6?EF?>/CD>1?CA==49C>B?<>;@B=C@?DD?D>A@-ACBDBBDEAB;>FD9BA?;A77)C62?>3@FDEACDCEG1?8EDA??DCGFAGGE@BA8@@?;DBB?E?7EB=AB==;C?:::>?5D@9B?4EC<,8=:GAEC8@G@GG?ED>->B?A=>@,@@?AAA@=8AB?@@:>@>B?AA;<=,A=@@=AB@:9@>?@ADC@CEA?C9@?;C;9C6BBEC<+4A=D:;C@EEF9==:C=;C?;CBCCDEF8CDCCF@$>B?;?9?B@BAB@>?<;A@?9D@C/:D?DDE9;AD?4>@>4DA1;F6D;567/A>=C<123E3F?B>A=A?A>E;:AB=6E==@@EE:ECED90?C@5B>$==<9.7=A98>9=-9>?:B8;@@:A?)AA=?AB>BDAE3CF@C?BEA?>?C:<;;E>BE?:?BE>AE9+9<@AE?3AAEDD:49@CABBFEFBEDC<@C=7@?BB9A>;=A=E=E@@??9G?:=>:>9?B;>A=FC1:DA:A<>@<>D7;@8@=17DC7CD=?@@BB@9@AACD<9?9EEA9;<>A2B@DIF?DEEFEE5?D=9/D?EI0EFHEBEBHCE>I1FEE=ID=HFHG(DEIG@=G?:C9DD=F;DCAG>@G@>E1GGH=EEB3C>-BDD9ABEB@@C:F6==E<@:?A??>==?A:<E;5A@DDF>;B>D0BCACBFB4?A3?B8<)?C>=C@:AE@6D??%8>:@@:B597-:<<@;<@=CF8?>3>E?>F @rCer/755/1890_57_CCS GGCTATTTGAGCATGCACAGCTGCTTGTCCTGCTCTCTTCAGGAGGCCCTGGTGTAGGCAGGTTTGCCAGTGAAGACTTCTTGGGTAGTTTAGATCCCATGTCACCTCAGCTGATATTATGGCAAGTGACATCATCCTCTCTTCAGCCCCTAGTGCTATTCTGTGTTGAACACAATTGATACTTCAGGTGCTTTTGATGTGAAAATCATGAAAAGAGGAACAGATGGATGTACAGCATTTTTCATTCATGCCATCTGTTTTCAACCAACTATTTTTGAGGAGTTTATCATGGGAAAGATCAGGGCTTTTCCCAGGAATATCCCAAACTTCAGAAACAAGTTATTCTCTTCACTCCCAATAACTAATGCTAAGAAATGCTGAAAATCAAAGTAAAAAATTAAAGCCCATAAGGCCAGAAAACTGCTATCTTCCTCTAAATATGATTACTTTAAAATAAAAAAGTAACAAGGTGTCTTTTCCACTCCTCTATGGAAAAGGGTCTTCTTGGCAGCTTATCATTGACTTCTTGGTTTGGGGAGAAATAAATTTTGTTTCAGAATTTTGTATATTGCAGGAATCCTTTGAAAATGTGATTCCTTTTGATGGGGAGAAAGGGCAAATTATTTTAATATTTTGTATTTTCAACTTTATAAAGATAAAATATCCTCAGGGGTGGAGAAGAGTTGTTTTCATAATTTGCTGAATTTCAGGCATTTTGTTCTACATGAGGACTCGTATATTTAAGCCTTTTGTGTAATAAGAAAGTATAAAGTCACTTCCAGTGTTGGCTGTGTGACAGAATCTTGTATTTGGGCCAAGGTGTTTCCATTTCTCAATCAGTGCAGTGATAAACGTACTCCAGAGGGACCGGGTGGACCCCCGAGTCAACTGGAGCAAGAAGGAAGGAGACAGACTGATGTTGATTCCCTCTCAGCCGGGACTCTCCCCCTTTCAAGGAGAGTGAACGTAAAGGCCTCATCTCCTTTATTGCAGTTCAAATCCTCACCATCCACAGCAAGATGAATTTTGTCAGCCATGTTTTGGTTGTAAATGCTAGTGTGATTTCCTACAGAAATACTGCTCTGAATATTTTGTAATAAAGGTCTTTGCACATGTGACCACATACGTGTTAGGAGGCTGCATGCTCCGGAAGCCTGGACTCTTAAGCTGGAGCTCTCGGAAGAGCTCTTCGGTTTCTGAGCATAGTGCTCCCATCTCCTGATTTCTCTGAACAGAAAACAAAAGAGAGAATGAGGGAAATTGCTATTTTATTTGTATCCATGAACTTGGCTGTAATCAGTTATGCCATATAGGATGTCAGACAATACCACTGGTTAAAAATAAAGCCTATTTTTCAAATTCAGTGAGTTTCTCAAGTTTATTATATTTTCCTCTTGTTTTTATTTAATGCACAATATGGCATTATATCAATATCCTTTAAACTGTGACCTGGCATACTTGTCTGACAGATCTTAATATTACTCCTAACATTTAGAAAATGTTGATAAAGCTCCTTAGTTGTACATTTTTTGGTGAAGAGTATCCAGGTCTTTGCTGTGGATGGGTAAAGCAAGGAGCAAATGACAAGGTATTAAGCACTGGGGCCTGTCTTATCTACACGCGAAGGTAAGAGTGGCCGAAACGACAGGGCTCAGCAGACTGTGGCCTGAAGGTCAAATCTGCCCACCACTCGTTTGGTGTAGTCTGCTAAGAATGGCTTTTACATTTTTAAATGGTTGGGAAAGAAAAACAAAAAGAAGTAGTAGTTTTTTGTAGCAGGTAAAAAGTAATGTAAAACTTAAATTCCAGTATCCATAAATAAAGTTTTATGAG + 5,-/2./0222.23/.,2121-310/1.)'34452022-342,01.2*,%%&/*#&0-../,06224462-54.2277479/:7332184'/56622.268/859*2357861)0**+/6.04376724985(.282:4753.5023.:,33'*(*(356A:79==7<:767>=9>;A<@@<66A=:-634==>*><==496@A6=7/5>?>?>:BA>A1/5;=;834A8./=15801;41&697/@>882'548:9523/:.)3-3.8:-:8/4.76C?A;9+&<765<=9,81,659:63;4:6B>6;344*+9-7;A<=4AB'@88B9<6;3;<=2=>:=<@168560??BB2<:A:I?<@@2?:D:?E3>03?;BA?>E&>;DB=FC<4>DE;GDID>:>@E/FEDA=?6@B<97D@@:AA:DF?<>GEE.55AE>0*=A9-B@;518;=@?DB8;6=.6?616>*=918=@0?6/3A@;96E<8+-2:&E>@@;DG<:A9C??E;:E@C8D82D>H>B=BJE:F@AB8A;IIFG:GEGJ8BHEHKH=DE?FED6A98@EAD+>AAAFA;EE>EBB6>?AC3FH>J@GGB=EG7IE;<HH=AG?DH4>;A>?,G;;,ABBA=:@:B>:@;C>=>B;C;7D?4JE8<3AI@2.=AFFDCA4<>E6AA083>5E@C<8331>:CH>I;FHI;=?@D;B@C>/A9;H8;:7@C5?@>?<@9:0>H?99217-?GA;D<:78D?0?FC@;D@;3;86/<2/AA/:@:DC:9==>?D.-5(>;=6.7=7F=CAC4E9D@?A6E@AB?A;I<5?D@EHC??9CC?2ABEGB7F@@=:7567ECF>>A><9;=3;=BC?B9F:CEB68,8&CFE>D95=CAG@?:A??/9A@=AE?=>6?<90-8;23:7>9;7<=98FA0=DI9>7@E=>D87CF@5;8>=<79->@?>8;939?@?@8?6@@>58-@?C::>;6A7<<=9.8>5<<37;.BAC90::A=3>6ADC=3<:/;:1@B;A?2/(<:9<3?;D2A=C=AB=B??76F>B88<>5>69>;6/AEBB;74=24<:7<=.@<836,80646A26@5/?*97;<681=;8;378=;8*>8:?ACCCF=@B?DA?::>:)>;;6<@7=(=A==>;B@@776*C>=:2'6<DB;?99040259?;':1>8>4779>=='8?<.>;B=A4<:?:?.B<@B=4?5:94+2);>9=;=8904'6:B@>.99@>:::AA>:50;9-;3>>>,9-756D:6?6ABADC7:A><>E@A77;>=B7>3A>B=?672A>+>82(3:3=0-;;>:625'35C96;C375:;<;<@;:=C8D>D?2=<366=>>:3-@<:EB;@:508=?9/;F@BD @rCer/756/0_2258_CCS GGGCCGGCAGCTCGCTCATCGGTTTCGTGGGCTTGTCGGTCCGTGCCTCGTCTCTCCCTGGAAAGGGAGGAGGCTCGACGTCGAGAGGAGCCACTGCCGCCGTAGTTCCGAGCTTGAAGTCGCTAGGACTTCTCTCAACTTGTGTGCTGAGAGACTCAGTGTGGCCTCAGCTCCTAGCTGAACTCAGCAGATCGGCCCATGAAAACTTCTGTATGAGACAAAGGAAAGGATCTGTCAGAAGCAACACTGTTATCTTGGCTGCAGCAAGGAAGAGGACAGTGTGGAGATCCTGCAATCTGAAAAGCAGACTGAAAGGTGACAAAGAAGCTGAAGATGGGTGGTGGAGAGCGGTATAACATTCCAGCCCCTCATCTAGAAATGTTAGTAAGAACCAACAACAGCTTAACAGACAGAAACCAAGGATCAGAATCCCAGATGAAGATGTTCATAAGAAAAAAGAAAAGAGGACATGGTTATAACTCATCAGCAGCTGCTTGGCAGCTATGCAAAGTGGGGGGAGAACAAAAATTTCCAAATAATCAGAGTTGGAATTCTAGCTTATCAGGTCCCAGCTTACTTTTAAATCTCAAGCTAATCAGAACTATGCTGGTGCCAAATTTAGTGAGCCACCATCACCAAGTGTTCTTCCCAAACCACCAAGCCACTGGGTCCCTGTTCCTTATCCTTCAGATAAGGAAATAATGACATTTCAACTTAAAACCTTACTTAAGTACAGGTATAAAGTAAGACAAATGTTAAAATTATGTTCGCGGGTAGTTGTCAATTGGTCTGAAACATTCGCTAAGGAATTAATCTATTTGTGTAGAACTGCTAATTAATGTAAAAAAAAATAGACGATCTTGTGTGCACTGTGATACAATGGTAGTATCAGTGCAACTTAAACTAATGGTATTTGATATTAAGTGTTCTCAACTGAGTAACTTTAAGTGGAAACCAAGTTTAGATTGGGGAGTGGTAAAGGAATCAGCTTTCTATTGTTAGGGGAAGATAGTAATTTATCATTCATGGAGTAGATTGTTGAAAGTTGGTGAATCAGATTATAAGCTTCAAGCTAACACAAGGATTCAGATTAGGTAAACATCTGAAAGTTTAGTATATTAGAAACACCCAAACCAGTAATATGCTAACAACCTGATGCACTGCTGAAGAAAATGTGAATTTTTGTAATAATTGCATTTAGTGAATTGTACAGTGGGTGGAAAGGGCATTTGGAGCTCATTAGAATGAGACATAGTACATCCCAATGGCCCTGTTTATTAAATATAGTGGATTAAGTGTCAACAATACACCAAAACCATTTTTTATAGAACAGTATTAATGGTCACTCATAGCTTTCAAAATACATTTTGTATACAGCACTGCACAAGCTATTCTATAGTGATCTGGCCTCATCATTCCTGCAAAGCTTGCTTTGGGGAGTTGGATAAGTGAAAATTTTAAGTACCTAGGGGAGAAGAGCCATGTACATATCTGTAATAACTTGTAGCATATGTAAAGTTTATTGGCCTTTATCTTACAAAAATGGAATATTTTAGTATGAATTTGCTGAATGTAAGACCGTGGACTGTTTTTATAGTATGGCCTAATTTTAAAGGTCCAAAATAATTTGTTTTTAAAGTTTGCCCTTGTGCTAAAGTGCCAGTGTACGTATGTTATACTTGATTGTAAACTACATTTCAAAGTAAATCCGAGTGTAGTAAGTTTTATAACTAAAAGGTTTAAGCTGTTAAAACTATTTTTAAGAGATGTGAATGCGTATGGGACTATTTTTTTTTTTTCCTCCTCTAGCCAAAGATTAACTGGAGTCCTCCAACCTTACAGATTTTTGGGTTTCACAATCTTATAAACAGTAGTTTGAGTATGGTGCCAATGATGTTTGGTTTTTGTTTGGTCAAGGGTAGGTGCAACCCAACGGACCATTTATGCAAAAGATGTAAACTCTTGCATAATACATTGATAACATGTTTTGCCACCTTAAGAGTAAATGCTTAAACATAAGCGAAACCAGTAGAAGGTATGTGGGTCAGTTTAAAAATTTTGATTGTTAATGCCCTATTTTGTAATTTGGCACCTCTTTTGATGCCTAAGCAGGTTAGCAGATGCCTAAGCTGTATTTCTCCAAATAAATCAAGATGAAGTACTGCCAAGTTAAATATTGATAGCCTAAAGATAAGTTATATGGTACTTAATGTACATGATATGAATTTGAAGCATAAATTAAATAAAATTGTTTTTCC + S$&+,(,+,0/'.0&+'().02%$002-$.*.*466646,&692.-658974-3/,775+6-::277.+82(41$3644203-284&6-35675.7/54+898:3+5(59:16020'57,9955.361*2687601#9/)2+*&(-50/-'*+10.163-/%38/6,0-353(4,5&3.8$6&441552,6::)6%85331+9842(696334'42/3.899&5)999;:09-3)741&986'72&+&2,1044.0%5+%$83<=3>%05?-:3>746%+%887=;;79>=45:>-:4:,;:;:9011388,=61;:;;=';<60>0=:>6>18&*52))6$$*33558&83..,;51':-==8,9=951'55*2<6=?(+*8:;13?*0<=2=;..91:.8;:<;;;;02$/5'5,=<9;:)*''*4>:49:67;:7'75=:94,:8'>===<+&;784*2?86;)-:%81.2:683/37:=<83:8>7+=3?;8'85-74=5;=05&977;)(-0=7'461.,=A'30B?:.79@?<'>'76B(>;AB<=B?@C6=A<,>/&89;6:7A?<.BAA%7>6ABA3=<=-+@=A6-0CA=056/68@1=:>3:>2:9.+35/86A)7>'>51)4)499/0=42@5?=-@?/9=5A)?==BA3?.A>=/??@@-?52$9%66?;C;;>:@>A7C:>@:0<;?=@;%9;='><%<&0;A4@4A:50.%<9/:AA';260+4<<;4B;9<8CC@>1B582*:<8;%*=<:A4B,@4B6=1::B@C1?,?;A:=><':87155>ABC68A>>3?&;6=@=:&;;;=?>>>A;+>3:;/5;=;898;66>);/AB<)1E?DD>9,?D=(850=4A0741DA&<8F=8'C/CBE58/5>;0@C(B)G3C+6<$CD98=AA>=CD*==5.?99>;90CCDC;B30CA6D?*A@4,=09=?8ABA48-'@?6/DA?,D>8G;@A9CA=B7>*:?1B9:A(18=,@>*=@9BCB?D*DB91E:2A8383)>6=.D?:5,=6(851?8:>1;?><=5F:@BDDC5ECFBE=44(993=>89=CC77&@DE>=<5EF5D)A;;6'A@9@@@:E5AC@?D5A>;6201:$><6@;>%;$330@.;B>8>,6/:;)AB:)@?<8(0'&95;=:6(-8629<79A>644?<@./+@;2(6(:=A?B5A==/A@=696@>;?'<9;76@AB6@9)AAA667@6>08+,(-6+=<<%9:?%;<=6.A54&:605&';438:C77@?>8.3:-<6/43>66A91;7;4.4:9<=:8%>;7,@B81B:C-B0>?B;<7B=<5CCCC66?7?>8)<=A@?66+;7=3=A?<8=+>AB74C@=,=7<1;668@&@<>;59=AAB2::0:<5>';?:.;B9;BAB&;;=+:C-?@@*?@@>(=><.;B=1BB5422;B<'>=3883<.58>36:6(26<59<7;66>64?C>=&6632,26%<951>>?;*A@=(=>=;9439164;2.??>.87>;4$:;81@&<83=:;1>37+=A:04.&<CCCCA?CC6A5+>;6916%=4;<<2&:%586.>1'3&@.+:>?82<7-AAAA:A@*7;98>.:95:B=;(7>@9'4-*+7==&;>B7=A4>:?(39;94@0A>4>%?=;750988A/8/>(=AA@7A9?:'=&<:/AA8A85:<5A8*9=A)@??<.0(9<;<2;=><63>><;<592=?.36.<:191>>';339;<1>7;>?7@@;:>99><%9;96(5888/=%82>:7?>=8A6:+>>?<4<=>/===9/<2??;5A>->.B>7BA5A,59(;?$:'860:5=<=;5==<97-6:02??>16%6((91388+=9>958,=9>=:-6040882=2?%94;>?>6<5$38*5,87:3???(8:)>==<(9 @rCer/759/1993_56_CCS ATGGGCATCTTCTCCATCCTCGGCTTCATGGCCAGTCACCTGGGCGTGGATGTGTCCCGCGTGGCAGACCACGGCCCCGGCCTGGCCTTCGTGGCTTACCCTGAGGCCCTCACACTACTTCCATCTCCCCGCTGTGGTCTCTGCTCTTCTTCTTCATGCTCATCCTGCTGGGGCTGGGCACTCAGTTCTGCCTCCTGGAGACGCTGGTCACAGCCATTGTGGATGAGGTGGGGAATGAGTGGATCCTGCAGAAAAAGACCTATGTGACCTTGGGTGTGGCTGTGGCTGGCTTCCTGCTGGGCATCCCCCTCACCAGCCAGGCAGGCATCTACTGGCTGCTGCTGATGGACAACTATGCGGCCAGCTTCTCTTTGGTGGTCATCTCCTGCATCATGTGTGTGGCCATCATGTACATCTACGGGCACCGGAACTACTTCCAGGACATCCAGATGATGCTGGGCTTCCACCGCCCCTCTTCTTTCAGATCTGCTGGCGCTTCGTCTCTCCCGCCATCATCTTCTTTATTCTAGTTTTCACTGTGATCCAGTACCAGCCGATCACCTACAACCACTACCAGTACCCAGGCTGGGCCGTGGCCATTGGCTTCCTCATGGCTCTGTCCTCCGTCCTCTGTATCCCCCTCTACGCCATGTTCCGGCTCTGCCGCACAGACGGGGACACCCTCCTGCAGCGTTTGAAAAATGCCACAAAGCCAAGCAGAGACTGGGGCCCTGCCCTCCTGGAGCACCGGACTGGGCGCTACGCCCCCACCATAATCCCCTCTCCTGATGACGGCTTCGAGGTCCAGCCACTGCACCCGGACAAGGCCCAGATCCCCATTGTGGGCAGTAATGGCTCCAGCCGCCTCCAGGACTCCCGGATATGAGCACAGCTGCCAGGGGAGGGGCCCCACCCCCATCCCGTGCTCCCAACACAGAGACTGGTGAGGCGGAGGCCAGGTGTCTCGCCTGCCCCCTGCCACGCCCTGGCCAGGACGGCTGCTGTCATCTTGGTCACTACTGCTAGTGCAGTCATTCGTGCTCGTGCCCCCAGTGTTTACACGTCCTTTGGATGCCAAGATGGCAGCTGTGGGGAGGGGTGGGAGTGGAGGGTTGCTGGGAGGTCCAAAGCACTTTGGAGGGGTCTCGGGCCAGGTCCCCAGTAGTCTGGGCGGCTTTACGTGGCCTCTGATACCCTTATACCCTGCCCTGAGCTGAGGTTCTGGGTGGGCCTCCAGCCCCATGGCTAGTGCTCCTGCCCTCAGAGCAGACCCCAGCCTCTGCCAGGCACATTTGGCTCTTCCTCCTAGGGGCAGGATGAGGGGCTGGGGGCTGTGCAGTGTTACTTGTCAGGCTGTGCTGCCCAGCCCTGTTTATCTGTGTAATTATTTTTGTAAACGTTGTATTCTCTGTGGTTGCCACCTCCGCACCCCCAGCCTTGGGTCCAGTCTGTCTTCCAGGCCTGCTTGCACCTCACTGGGCTGCTCCGGGGTCTCTGCCCCTCATTCCAGCCCTGGCTGTCAGGCCCAGCCAGCAGAGGACCGTGACCCAGCAGCCTGCCCAAAGCATTTGTTTCTGGGGGATGGGGTAGGGGCTGCTCCACAGGAGGTTTGAGCCCAGCGTCCCGGGGAAGGGGACCCTGCACGACACCCCTTGCCCTTCCTCCATCAGGCTAAAGGCCCAGTCTTCCCAAATGTGCTGCCCTTGTTCATGTGCCAAATGGCCCCAGCCCACATGCCCCTCCCCTCTCCGGAGCGGAAGCCCCCAAGTGTCTGAATCCCTGAAGTGTCCATTTGTCCGTCCTCTGTGCAGTGACAGCCCCGGCCAAGCCACCTCTAATCCTCTGTAGCAATAACGGTGCGCCGCCCATCCCTGCCCATCGTGCACCACTAAGATTTTAAAGTCCATAGATTTTAATGAAATTTCTATTCCTGTCTC + ;;DF:EB@EE.AF;@AEEFGFFB@=FEDFGG=EB>F>>@AABAB;A>CEDD:?CBE?CFB:GGD@>@DBGE8BCCF=CAFEB>C$?FB?FFB:D@>;?B5?CB=@DFCAE7EECBE2?FCEBB?:?F?GEGBEGG?FDGG59AB@FCEAF===CC78F>D?<=AD>DEDBB=BCEE7:5FFC@G;D@GEBEF>F:D;BAG=FEDBEC4?EC:FA3;GGG0E?CE=FFGACEFEEF:EDFE<5BCFB:;A5DCC>DFGCFFGGDF=CCD==;EACG@EABEBFBCFGFCAFEEEE@FEBD?D7>EE?5>AFD??A;ABGA2:BB>CA<<>@CA:5>??@;;58B:;96:BC@29FEEC>FE@@$A?6CEG@56=E@FGGEEABEB@E47CDFGGED6AFEECFECG2FGA;@?'ABFEF?E@BD<>D?AGDE?EFE?DEECC<=B?A=@FB9FED@D<=:EEC@E=;CCGBD3=?FEGGFGEGF?EC?9@DCAGGFCEHGGBH@?G@FJAII?GFHDGAGADB3DF?HFFIFCHEFIEHJIIIIJJJ;IGF<>?GJJ@HDGJEEHHIKHIAH=E@FEGEEHIIFJ@JHDIKHHA6H=DFJHJKHKIJKKKKKFJJKFFKIHK6GK>JHFKFJJKEBFIJJFJHHKKKEKHKJJJFHGJIJGBHIJA?JHHKK5IJHHJGJHGIKKJK>IJJEDK+FGJJDHKGKJHJAGHJKHKIJJFKIHCIGJIDHKK?FKAC-@HJ(HGDE;BIK>K>JKJKKCHJEHKBII?HGGFII4KIJKKI@JII2HF3EKJK?BHKK>DE?IKFG?AIIJJ9JHCB:=IKJIJHEIJEGIK?IDDHKKCK?;K)IFJKKDKKJADJFFHKK9JHKKKJ)FHB=FDIJKKK?7JJKIFHIKGHKKCCKJGHE7BJJKGJKFI=IJKJDDCFJ?KFHHJJI6IEJI=KHGFJICDECECADGIFKIKKH@GFIHKKBJI9BGHFIHIJJKGGCJJHDEHKGHID@9HIKK@KJJKHCGDGIEH>5KKI1HDHHJ@JKICEJJJHI?KJKHK(J?GJJAG8J?HKHJDKIJGHGHH;K?JI+KJJDK;KG3CE7IJIJIJCHJ@JIKJFIIIHFEJ8KK@@KGKKK@JKJKAGHHHJJJD'CIKF2BAAF@KIIKIKFKFCH>JJJHDJIFIHIJKKIJJK1KEKKJIKKHIG=CKKIKJKGJFGHJ,JH;FDJDG;DFFIKK>IF;HDJ8GJ:KHGKHKEGHIIIK @rCer/760/25_2364_CCS ATGGGGGCTACTCGCACAGCAGCTGCACGTCCCTGGGATCCACATCTCTTCCAATTTGCAGCGTAGCCCGAGTCGGTCAGCGCCAGAGGACTCAGCAGCCATGTCGAAGCCCCATAGTGAAGCCGGACTGCCTTCATTCAGACCCAGCAGCTGCATGCAGCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGACTCACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACGTTGAAGGAGATGATTAAATCTGGAATGAATGTGGCTCGTTCTGAACTTCTCTCATGGAACTCATGAGTACCACGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCTGACCCCATCCTCTACCGGCCCGTTGCTGTGGCTCTGGACACTAAAGGACCTGAGATCCGAACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTCAAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTATGGCTAGACTTACAAGAACATCTGCAAGGTGGTGGAGAAGTGGCAGCAAGATCTACGTGGATGATGGGCTTATTCTCTCCAGGTGAAGCAGAAAGGTGCTGACTCCTGGTGACGGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAAAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTCGATATGGTGTTTGCGTCGTTCATACCGCAAGGCAGCTGATGTCCATTGAAGTTAGGAAGGTCCTGGGAGAGAAGGGAAAGAACATCAAGATAATCAGCAAAAATCGAGAATCATGAGGGGGTTCGGAGGTTGATGAAATCCTGGAGGCCAGTGATGGGAATCATGGTGGCTCGTGGTGATCTAGGCATTGAGATTCCTGCGGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGGCGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACCCGGGCTGAAGGCAGTGGATGTGGCCAATGCAGTTCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGATTGCCCGTGAGGCAGAGGCCGCCATCTACCACTTGCAATTATTTGAGGAACTCCGCCGCCTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCCTTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCTCATCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGCTTCACCAACACCATGGCGTGTTGTTCCTGTTGCCGTGATGAACCTGAGAGCCCTTCCTCCAGCCCCCTGTCCCACCCCCCTTCCCCCAACCCATCCATTAGGCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAATGTGGCACTGGTGGGCTGGGACACCAGGGAAGAAGATTAGTGCCTCGCTGAAACATGCTGTGTTTGCAGCCTGCTCTAGTGGCGACAGCCCAGAGCCTGGCTGCCTATCAGTGGCCCCACCCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTTCTTTCCTGTGTATACTCCGTCCAGTTCCTTGAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCCTGGGTCAGGAAACAGCTAGAGAGTTAGGGGCCTTAGGGCAAGGGGCTTGTTGTCCCCTTGAAGCTGACTCTGGCCCTGGCCCTTACTTGCTTCCCAGCCCCCTGGGCCTCCCCAGTTCGCACCTGTCCCGCGCCCTCCACTCAGCTGTCCTGCAGCAAAACACTACCACCCTCCACCTCACCTTCCATTTTCCCCACTACTACTGCAGCGACTACTGCAGCGCCTCCAGGCCTGTTGCTATAGAGCCTACCCTGTATGTCAATAAACAACAGCTGAAG 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500666663.*515.215.0052264-116336/(,-))-./35666443++16)210-)401'/-,521.04100.01445*2,5302.#+/',*&1564)3+46.53)21..0)-/4,01/.$/+25.01+42--/.-35-250-45200414213/3/4'1030/13041/$0.215615-.,-.0.0000%&,///044664,(35155,6515251//+5000.34/13*0,0224+0210+33/24#*&)/,501/)*1//--662.0.143,(0015,6503030.243624256-.-404332(5.+24%+0-/2233+2$)///2.6+03'0'4113/005*266012)*/113-(-5.21-',.03.514(/.0-.(10/1,+12515260/),+*&%264/,'-2'('+54030.023)1./252325120460-523242114613654.-%,.*/424+,.-355024*05513-1365242454/02--11/3'0234,4.'24,.)23/,/+015.,/-36060-103/55-4(.004//2/)/'-,'244,010--..-(051-#/54-1056*0251.2.2(+'&()(&$$''&*%,.&-,$2356632905.702350)433)2%%*+3.*-*1*..-,94/693665987-420-(571*4433..25.13.)39665441/4/2-40337195:859756-503403.27:(8*47187914.).82'1'1.100/-27*,0673+6)167237788525/99:565+05*,32:991/*$-1.1-338839,/),462(-2/33664867:/,"'303*6.5.64244/2.2013&+7661.4.56/8678543)-0/-,.*114:.854-674:4392/,-3/01-)%-32679990-231233/+3589606043*-'7352324755+324013.53,6339(0.%3740.(.+*&%'(),')43411.2,145:6:55-24*3*5004.,/71/**4835/..886450:8:56,-14+0$*%'039993620109:423:231/4147757:/5288/+462513,1.*02/1.**$//0326:257-%.-36,30.3,1,*65134,/-84)2-$+4+4/0769131967::;56(03211-2)330/7019824%*5/0572,/+7,833:957,55.96696983.949::77252/0437654015.59097086:7:1409961035243,50/-26530555:88*2/9.9347/7184&13:5027166:86:.5661369/101468064(/)/068623006+8:,77/*,.5.87:35+4724+596;9950500-729/888175516750/-+6:5988777,3:945.426/014/&0242263-3&054;8*-50/0*5:04500107467-4067457052/+-3637,63&4/.59577:5084.3507+545562642794&$83)/531-/37:95:2'56439162+28873.9430922854576023..104235:4/56,2+1/45668'72303-5.56480/7695:0/2:;653:7+252424:9/:-7/2+5:8:5:128/646:34:649-,5201*,.04+462&$2/2)+0-2-1-.03.31.#-/...(01)2+,--)/0+2/154.),&(+,00203'/0114662651$/--0/.21541&1'*-'(.'0420*.*4650'3./+3./$++/,550,211/),,2+3/2323.)10-//('-102(1-01/013161/3012,/'&+*+5.%,*,/11011/2//*/0-4+.$.20,+$226340565350-0-((.0).-*,+%-11.14+21252263'0*,.&,101*,$0*404,2+$.+$/22/3+*/((.*01231613,,*,*4+3536/34'443.*550.4/)11*/,$.%(%'2554,0.*'+,.,0042.1)('&$%+-/62.00%**1*)+0..,$-0.-01-/../'/.0//*-+00%*(-2,2,+-3+1/+,//,025-/34.22510++0+.00%.1,+3-+(.1&232*0(./&/0-1//&)(,%*+*,*,,1)..11,2,10+*.022+,'/***0,1&*+,/)00,-/)+1-2*)1/-10*,+,*&(*+-0-./#**)+&)')',-1/,.1.0*)/,0./-%++))((,#(+.&.+%)('#)'$',1020/1'0/&$++-"-&$'+#((,0''*&)..*,*,-('**)+-+20..,.*/*+++&*1.,,,),1.%..01(,*+,,*-,'+%.(,*+*.-**-' @rCer/763/24_2164_CCS ATGGGGCACCGCGTCCCGTTCGCCCCGGCTCGCCCGGCCGAGCCGCGCGGCGCAGCTGTGGGCAAGGGCGGCACAGAGCCCAGGGACCCCTAACGCCTGCTGACCACAGGCCATCTCCGACTCCAAACGAACGCCTCGTTGCTGATCGGCTCGATCAACCATCAAGACTTAGAATATGGAGGCGTCGATGGACGTTCTGAGCACATTTAATGAAAGACTGAAGATTGTTTTTTACTGAAAAATCTATACCAAGGCCTGATTCCTCTCTCCTCTGATATGTGGAAGAAGCATGCAAGATACAAGATAGTCAAGCTTCTTTAGATTTCCTCTCCAAATGGAAAAGGTCATCTGGTCACTTGACGCAGAAGCTGAGGAAGATGTCATTCTGATACTGTCAGAGCAGAAGATGATGAAGAAAACGAAAGTCCTGCTGAAACAGATCTGCAGGCACAACTCCAAATGTCCGAGCTCAGTGGATGTTTGAACTTGCTCCAGGTGTAAGCTCTAGCAATTAGAAAATCTACCTTGCAGAGCAGCAAGAGGCTCTCTCCAGAAAACAGCAGCAGATACCAAAGGAAAACAAGAACAGGCAAAGAAGAAAAGGCTCGAGAACTCTTCCTAAAAGCAGTAGAAGAAGAACAAAATGGAGCTCTCTATGAAGCCATCAGTTTTATCGTAGGGCATGCAACTTGTACCTGATATAGAGTTCAAGATTACTTACACCCGGTCTCCAGATGGTGATGGCGTGGAAACAGCTACATTGAAGATAATGATGATGATAGCAAAAATGGCAGATCTCTTGTCCTACTTCCAGCAGCAACTCACATTTCAGGAGTCTGTGCTCAAACTGTGTCAGCCTGAGCTTGAGAGCAGTCAGATCATATATTCAGTGCTGCCAATGGAGGTCTTGATGTACATTTCCGATGGGTGGTGTCCAGTGACTTGGACCTCAGATCATTGGAGCAGTTGTCACTGGTATGCAGAGGATTCTACATCTTGCCAGAGACCCTGAAATATGGCGTCTGGCCTGCTTGAAAGTTTGGGGCAGAAGCTGTATTAAACTTGTTCCATACACATCCTGGAGAGAGATGTTTTTAGAACGGCCTCGTGTTCGTTTGATGGAGTGTATATCAGTAAAACCACATATATTCGTCAAGGGAACAGTCTCTTGATGGTTTCTATAGAGCCTGGCACCAAGTGGAATATTACAGGTACATAAGATTCTTTCCTGACGGCCATGTGATGATGTTGACAACCCCTGAAGAGCCTCAGTCCATTGTTCCCCGTTAAGAACTAGGAATACCAGGACTGATGCAATTCTACTGGGTCACTATCGCTTGTCACAAGACACAGACAATCAGACCAAAGTATTTGCTGTAATAACTAAGAAAAAAGAAGAAAAACCACTCGACTATAAATACAGATATTTTCGTCGTGTCCCTGTACAAGAAGCAGATCAGAGTTTTCATGTGGGGCTACAGCTATGTTCCAGTGGCCACCAGAGGTTCAACAAACTCATCTGGATACATCATTCTTGTCACATTACTTACAAATCAACTGGTGAGACTGCAGTGAGTGCTTTTGAGATTGACAAAATGTACACCCCTTGTTCTTCGCCAGATAAGGAGCTACACAGCTTTCTCAGAAAGGCCTCTGTAGAGCCTCAAGTCCAGTCCTCTATCACTTTTGCATGAATTAAAGTATATAGCGCAAAAGAGCACCTAAGTTATAAATGTGTATATATATATATATATGGAATTGGAACTTATTTAAATTGTTGGAGTTCTTTAAGAAGAGTATAAATTGATTATTTTTTTATTTAAAGGGATAGTTGATTCTTGGGTGTTTTGAAATTAAGTTGGAGTTTAATTTGCTTAAGCATATTTATGTTGTGAGAAACCTTCATATGAAGTTTATCATGCCCTTTTTTCAAGCAGATTTATGAGCAGATTTCTGTCACATAAGTCGTCTTCTACTTGAGCATCCTAATATTTAAATACATCAGGGGAGAGCTCCACTGATAAGCATTTTATTCCCGCATGGCATAATGTTTTTGCACTAAAGGCTCAAAGTGTGAGAACCTGTCTGGATTTGTTTGAAATTGTTTCACCAATAAAGATCATAAATAAATGCTTCTTTC 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@rCer/766/1934_57_CCS ATGGGCTGTCCCGCACCACACAAGGACGGACGGAAGGCGCCCTCAACTCGCTGGCCTGGCGCCGGGATGGCCCCCAAATTCCCAGACTCTGTGGAGAAGCTCCGCGCCGCCGGCAATGAGAGTTTCCGCAACGGCCAGTACGCCGAGGCCTCCGCGCTCTACGGCCGCGCGCTGCGGGTGCTGCAGGCGCAAGGTTCTTCAGACCCAGAAGACGAAAGTGTTCTCTTCTCCAACCGAGCAGCGTGTCACTTGAAGGATGGAAACTGCAGAGACTGCATCAAAGATTGCACTTCAGCACTGGCGTTGGTTCCCTTCAGCATTAAGCCCCTGCTGCGGCGAGCATCTGCTTATGAGGCTCTGGAGAAGTACCCTATGGCCTATGTTGACTATAAGACTGTGCTGCAGATTGATAATAGTGTGACGTCAGCCCTAGAAGGCATCAACAGGATGACCAGAGCTCTCATGGACTCGCTTGGGCCTGAATGGCGCCTGAAGCTGCCCTCTATCCCCTTGGTGCCTGTTTCAGCTCAGAAGAGGTGGAATTCTTTGCCTTCGGAGAACCACAAAGAGATGGCTAAAAGCAAATCCAAAGCAACCACAGCTACAAAGAACAGAGTGCCTTCTGCTGGGGATGTGGAGAAAGCCAAAGTTCTGAAGGAAGAAGGCAATGAGCTTGTAAAGAAGGGAAACCATAAGAAAGCTATTGAGAAGTTACAGTGAAAGCCCTTGTGTAGTAACCTGGAATCTGCCACGTACAGCAACAGAGCGCTCTGCTATTTGGTCCTGAAGCAGTACACAGAAGCAGTGAAGGACTGCACAGAAGCCCTCAAGCTGGATGGAAGAACGTGAAGGCATTCTTACAGACGGCTCAAGCCCACAAAGCACTCAGGACTATAAATCCAGCTTTGCAGACATCAGCAACCTCCTACAGATTTGAGCTAGAATGGTCCTGCACAGAAGTTGCGGCGGAAGTGAAGCAGAACTACACTAAAATCCCAACAGGGCAGCCGGAACCCCTGCCTGACCTTACCAGAGAAGCCACGGGTCACCTGCTCTGTGCCCGCTCCTGAAACCCAGCATGCCCCAAGTGAGCTCTGAAGCCCCCTCCTCAGCCCTTGATGGCCTTCCACCCTGTAAGAGGCGTTGCTTGTTCAAATTATGCTCAGTGTAGTCAAACACAGACATGGTGGTTGCGCCAGAAAGGTCCCCACTAGGGCTAAGCGTGAAAGCTGAAGCCCTGTCTCCATTCCCCAACCCAGCTAGCTGATCACACCAACAGATCCTCATCAGCAAAGCGTTCGGCTTTGTCCTGCCCAAGTGTGCTGCAGACTGAGTGCTGCCCTTGTAGTTCCCCAGACCCCACCTCACTGCAGTCCATCTGAACAACCTTGAGCTCCCGGGCAGGGGTGGGAGGAGGGGGATAAACCTAAGGCCCTGATCCAAAGCAGCCTGTTGAAGCTGGTTTCTCCAGGGCTGCAGTCTCTCCAGGTGTACAGCTGCTGTCCCTGCCCTGCCCTGTCCTTTCCTTGCACAGTCTCCTGTGTCTGAGCCCCTGTGCTTCTGTTCAGGCCCTGCTTTGGTGGGAAGGCGGAGCCCTGACCCTTGGACAGCTGTCCTTGACTCTGTGCTGCTGCCTTCCGCAGAGAGGCACCTAAGCTGATGAAAGAGCCCAGTGATTGTGGCCACTCCTCCTCGAGGTGGGAGTGGGAGAGAGCCTCCTTGGTCAGTGTCCTGCTTTCTGGGCAGGGATTTGGCTTTTTTGTTCCAACAGTGGCCTTCTCCGGGCTTCATAATTCTTTGTAATATGTTGAAGTTAATTTGAACTGCTGATTTTGTTGAATTGTGTGTTTAAGCTGTTGCATTAAAAGGCTTTCTTC 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@rCer/768/2223_71_CCS GAGGGACGGAAGACCCCACCAGACGCCGCCGGACCAGGAGGACGCTTCTGACGAGGGACCATTGCAGTGAAGAATCGGTTGACTATCAGGGCGGTGCCAGTGACGGCAACCAGGATTCGGCCGATTCGGCTGCCAGTTTTTGGCGGTCATCAGTGATGACATGGGATTGACCCCGATTGGCTAGTTTACCTGTGAGACAGTGCATTTGAGCTGGAGAGAGAATCATAATGTTTTACTTAAATACGTAACGTCACAACTTCGGTACAATATGTTCCACGCGCGGCGGGGCCTCCTTGTGGAATCTGGGATGAGCTCAGGCACGATGGATTCGGTTAGGTCATGGTGACCATTCTCGGGGCAGTCTTCAGGTCGGACCGAAATTTGTGTTTGGCCAGAGCGGAGATGGTATCTCGCGCGCGCGCGCTCACGATGGGAGCCGTAGACTGTGGTCGACTCGGTCTGGAAGTGGTTGTGGGAGGAGGTCAGATGAGCCTGTTGGACGGGTGTCTCCGGGCTTTCAGCTGAACCATCTTTCTCTCGGGCCGGGCGGACCGGGTCCGGAGATGGGACCTGTCTATCAGCAAGGATCGGGGAGGTACGCCAGACCTGCATCATCGAATCACACCTTCACGCGTCTATGCACCTCACCCATAGGTGTTCGACACGTGGTGTGAGCCTACAACGCCACTCCTCTCTGTTCCACCGCTGGATTAAGGAAACACAGTATGAAGCCCTTACTGGCATCGATAATTGAAAGCCCTGTTACGACATCTGCTTCGCGCTATCTGAAGCTGACTGCACCGCCCACCATCTGTGGGACCTCAACCCCTAGGTGTTCAGGCCACATGAGCGGGACGGTCACATCCTGCCTGCGCCTTTCCCGGGCAGCTGACGCAGATACCTGGACGCCAAGCTGGCGCGTGAACGATGGTGCCCATTCCCGCGCCGGCTGCACTTCTCTGCTATGCCGGCTTCGCGCCTGTCATCCAGGGCGGTCCGGCAGTCCAGCAGTTGTACGCGCGCTCACGGTGCCCGAGGTCGTCATCCCAGCAGATGTTTCGACTCCCAAAGAACGCCATGTGGCCGCTCTGCGACACGCCGCCACGGCGCTAGCCGTGACGGTGGGCTGCCATCTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGGAGTCAGCATGCTCAACGTTGCAGAACAAAGACGCAGGCTTACTACGGTGGTAAGATGAGGTATCCCAACAACGTGAAGACGGCGTGTTGCGACATCACCGGCCCCAGCGGCGTCTAGAAAGATGTCGGCCACCTTCATCTGGTCAACCAGCACGGCCATCCAGGAGCTGTCAGCGGATTCTCCGGAGCCATTTCACGGCCATGTTCCGGCGCCAAGAGCCTTCCTTGCATCTGGTGTATCACGGGCTGAGGGCGATAGGCGAGATGGGAAGTTCCGGTACGAGAGCGGAGCACTCCATGTAACGACCTTGCGTGTCTGAGTACCAGCCAGTACAGGCGCCACCGGTCCGAACAGAACAGGGGGAGTTCGAGAGGAGGAGGACGTAGGGCTGGAGGACTGAGGCGTAGGTGCCCCGCGAGGCGGGGGCGGTGTTAGGGGAAGCGGAGGAGGAAAAGCGAGGGGAGATGGGGGAGGTTTATCCCGGGACGTGGTACCTTTGGGCGGGTCAGAAGGAAAGAAGCATGGTTCTCTTTTGGATATGTGCGCTGATGGGGTCTCTGGTGATTTCACTAGTTGGCATGTCACTGTTTTTTCCCTTTTTTGTAATATTAGAATAGACTATCATGTAACATGTTGATGATATTCTGAGATTACTGGTTGTAGGCGTAAAATAACATAATACGTGTGTACGGAAATTTGTAGGTTTGTCCTTCTTTCTTCTCTTCTCCTTTTTTCTCTTTTATATGACGATTATCATAATGTAACTCTGAACACATTTTTCTGCAGTTATTTTTAAATTCTTCCAGTTGTAACAAAAAGCAAAGGCCGGTTTTAGCGGTAAAAGCCTTTCAAATGAAGTATTTATTCTATTGGGTATTGGATAAATTGAACGCATTGATCACAGTTAAGGATGAGGAGATCAACTTGAGTTTTTAAATTACTCTTTATAATAAATATTAGTGAAAACTACTGTCTCTTGAAAC 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$+&$%...+*(--'#$(&#+-$,.-+-/%*/),-#*.),-%#,,,.%$,.-).&#+%(),..(,-#...-&..".-.++#'))'&&','*"'.+-/*-.+..#,.)*,(,+&#++#*-,(&#"#%+++)-*.''-,-%(#%'$()$$&'&)"+%$%'-'-+--+()-#-**)'("%%#-('%(#'#(),,./"--,'.*../#-.(*&#%+'.)&"(-')**.,&#")-,)'++",+$,*"',)-%&,"'-$"%',+*#".+.-(**/...&&+'%%#,-,-%'-((')%.,-.)-).%(+.),",%#).+-,".)/*"../.-.+&%'%&&'#,-)-#",.+#)..(-*$+$&$*&#()..,-%%+-)%.+'$,$&('#)$,+*+#+)-(&**-*(('',*$,+'#'&)&((&(')%)(**+)*+-,/)+.+'))**##,-,'&#,,*-#.&)-+.&%---),%-&%##$%++(#(,$.#,..-.*'//.&-,.+',##-($$.*.+-*).+)($+*/-//*/)%-%*#'-$+).--),%##',($&-%-*,')'&'*')"),%+&##&#)&(-".*+-..**($..)"(&$*&*,-."),%...."....'*)"/*+"".//...).*".-/..")+/-"-%.,.-+*-"*.*...)..,,#&'$,&,-#'-'*(-,,+'.&++)&",*'-..+.*)+,..,/.-/+#,$&#.(.%---/,/)...)("%$)"+++/.#.).&.#..+&'./)#.*,,.."&+./-+//'+/+.).#-.&"&"../+,.../..$",+.'#(++**,$.+",#*%$,,,)&(")%)#(".*..-$.#/+''*(..)#-*-*$#""+../.*"-)./+/..-/)#&+%+*'-''-&%../+/../.(#),--($#-/+.,-//./,-,(...&-/#/+.*('")*"-),+%(,-&%"".-.-.//)*.-)","$).*-.+.+*..+$&'$",+.#-&-')'*+$&#",&--."-++.*,.$+",-.-./,/....*.,..+-,..-%%.")+)%#,-./.-..+.*$*-..-.,$&"()&%&(""+,'&",'&-.-#/./).,("&.**/*,",.&*..),"--"..&+.+-."),./+.,/+.)&++$#$)+&'+*%)'+....,.).&,'+#,+&$''#--.",./..--""..(.'+-#*%,*+&-(....&."+.-."..".+,*)-.".'"")#,-&*)*-,--%/&/,*//*().---",.*/.%./+"*+/))+)+")--'-$(-)".+&&-+'&(,.)*.-..-(+,,%"'('*+-&-././.&&(--/...$+$-...-/././(./*/.+*/+/.,".$')&-$/**.////*.-/*.(&*+%.$-*.,),&'")'.(.(#%$,+*"..-.,(*#(,*&&$#&--.)-%,,,'*$&#''+$)$$$%$))($)'+"'+*+'$#"(*,,&)**(%()"#,',,%',,%,,,,+*,+&"+)++,,,%*,'%**#+%$''%&%%%&,&-,-'#'&--.'*+&**)',+('&%$!#(++'%%&"+'&'.-'/+.+..*,/+..*,*,/.//.+..(#'&#+$##$)',(''-'.'.*,-'-+#'+)".,-)"+%&#%")('*'#.-*"+*%.-*,,+%.(##+'-+%*-#&"+$(#*%-+$.&)-)%)'..*.#-.++&&..--#(*,%#"")&&,,-+++"#%#*$,--,)'%-&#(%)&+--"-")*)+"&--..,*"$%%&$)(($%$&%(#-%$#$-,%$+"(-".--"',&$,,%*+)-*$+*.."*&+,))+..+",,)..("#%'.*&'&,"--))+.".&.+.-$,.)%(+*,#-)#(&'+"#&$**$'$#,*(("#*)'*.*).,+.#..+(*&&))+"-+%(*+.."-"-..,-$#..."+%%&(-*%%*-.'+.''%&)##'+",--"-$"-*)#&-+(*(.-*-,""-'#+.+,+(*%-..#+,,&,-*'&#"#'"&.+.-&(+.%,%'(-,$*,-&,"'&(#$-*(--",)&%#,-,#+&"&'+./(/-)+#-.)#$.///&(-.)&-#(...,$+////.-,+''/.-.(+*)/+.+$--#-,$,"-#",%**//.)/,../*).-',/$/./-)-)..&-. @rCer/769/1480_59_CCS ATGGGGCTTTCTTTTTGCGGAATCACCATGGCGGCTGGGACCCTGTATACGTATCCTGAAAACTGGAGGCCTTCAAGGCTCTCATCGCTGCACAATACAGCGGGGCTCAGGTCCGCGTGCCTCTCCCCGCACCACCCCACTTCCATTTTGCCAAACCAACCGCACCCCTGAAATTTCTCCCCGCAAATTTCCTGCCGGCAAGGTTCCAGCATTTGAGGTGACGATGGATTCTGTGTGTTTGAGAGCAACGCCCATTGCCTACTATGTGAGCAATGAGGAGCTGCGGGGAAGTACTCCAGAGGCAGCAGCCCAGGTGGTGCAGTGGGTGAGCTTTGCTGATTCCGACATAGTGCCCCCAGCCAGTACCTGGGTATTCCCCACCTTGGGCATCATGCACCACAACAAACAGGCCACTGAGAATGCAAAGGAGGAAGTGAGGCGAATTCTGGGGCTGCTGGATGCTCACTTGAAGACGAGGACTTTTCTGGTGGGCGAACGAGTGACATTGGCTGACATCACAGTTGTCTGCACCCTGTTGTGGCTCTATAAGCAGGTCCTAGAGCCTTCTTTCCGCCAGGCCTTTCCCAATACCAACCGCTGGTTCCTCACCTGCATTAATCAGCCCCAGTTCCGGGCTGTCTTGGGGGAAGTGAAGCTGTGTGAGAAGATGGCCCAGTTTGATGCTAAAAAAAGTTTGCAGAGACCCAGCCTAAAAAAGATACACCACGGAAAGAGAAGGGTTCACGGGAAGAGAAGCAGAAGCCCCAGGCTGAGCGGAAGGAGGAGAAAAAGGGCGGCTGCCCCTGCTCCTGAGGAGGAGATGGGATGAATGTGAGCAGGCGGCTGGCTGCTGAGCCAAGGCCAAGGACCCTTCGCTCACTTGCCCAAGAGTACCTTTTGTGTTGGATGAATTTAAGCGCAAGTACTCCAATGAGGACACACTCTTCTGTGGCACTGCCATATTTCTGGGAACACTTTGATAAGGACGGCTGGTCCCTGTGGTACTCAGAGTATCGCTTCCCTGAAGAACTCACTCAGACCTTCATGAGCTGCAATCTCATCACTGGAATGTTCCAGCGACTGGACAGCTGAGGAAGAATTGCCTTCGCCAGTGTCATCCTCTTTGGAACCAACAACAAGCAGCTCCATTTCTGGAGTCTGGGTCTTTCCGAGGCCAGGAGCTTGCCTTTCCGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACAGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACGCTGGTTCGAGAGTTACTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTTCAAGTGAACATCTCTTTGCATCGCCTAGCTGCCTGCACCTGCCCTTCAGGGAGATGGGGGTCATTAAAGGAAACTG 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@rCer/771/213_65_CCS TATGTGGACGAGGGACAGAGAATGGACCTGGAGCCAACGAGGTTCGGCGTGAGTATGCATGCAGAGCGTGCCGAGCCGCCGTGTTCGGCAGTGAAGGAAGACTGACCCGTCACACCTCCCTCTCCCCAATTACAGCCACGTTGTACAT + ($')'*$+*-&,)%.-$-,--"()%*%",*'+&$*&(,,+&*,'*,'+"++"$'((,)'%,%"'$*),*+$*"*(%*+%$+*('%'*&$&&&'+$,'-",-*-+&-+*.)-"+"))-))%#),%$*(-"$$)-)/(+,,.%"##),%- @rCer/772/3924_55_CCS ATGGGTGGCGGGAGCAAGCGACGGCTGAGCAGTGAAGACAGCTCCCTGGAGCCTGACCTGGCCGAGATGAGCCTGGATGACAGCAGCCTGCCCTGGGCGCAGAGGCCAGCACCTCGGGATTCCCTGAGAGCCTCCACCTGTCCTCTCCACGGTGGCTCCCGAGGCCCTTCCGCTTTCCTTCCTGAGCCCCAGATACTTATGAAGAAGATGGTGTGTGTACTTCTCAGAAGGGCCTGAGCCTCCACAGCCTCTGCCGGTCCCCTGGCCTACTGCCTGGGGATGTCTGTACCCGGGACGACGTCCCTTCTACAGATGAGAGTGGCAGTGGCTTCCCAAAACCAAGAGGCAGCCCTGCAGTTGGAGAGGAGGATGACGACTACCAGGCGTACTATCTGAATGCCAGGTGGGGCTGGGGGCGAGAAGAGAAGGCCGAGGGCGGGCTGGGGAGAGCACGATCTGTTGCTGGGCTGAAGCCGCTGGAACAGGAGAGCCGCATGGAGGTACTGTTTGCCTGTGCTGAGCCCTGCATGCACATGGCTACAGCAATGAGGCTCCCGTCTCACCGTGGAGCTGCCAGGATCTGCTAGCCCAACCCACCCGACCTCAGGTGAGCCGCCCCCTGCCAAGGCAGAAGAACAAGGTATCCACGAGCCGTCAGACCTGGGTGGCTACCAACACCCTGAGCAAGGCAGCTTTCCTGTTGACAGTGCTAAGTGAGCGTCCAGAGCCCACACCTGGCCTTCCGAGTTGGCATGTTTGCCTGGAGCTGCAGAGCCTCCAGCTCTACCAGGCCTTGGAGGTGAAGCGCATACCAGGAGTCTGAGGTGGCTGCCTTGCTCAAGAAGATCCCTCTGGTCCGAGCGAGATGAGTACCATGCGGTGCCGGGCAGAGAGCTTCGGGAGGGGACGCTCTGTGACTATCGGCCTGTGTTGCCTCTCATGTTGGCCAGTTTCATCTTTGACGTTCTCTGTGCTCCAGGTTCCGGCCCCCAAGTCGCAACTGGAACAGTGAGACACCTGGGGATGAGGAGCTGGGATTTGAAGCAGCAGTTGCTGCCTTGGGCATGAAGACAACAGTAGCGAGGCAGAACATCCCTCTTATGTGAAGGTACACGTCGGGAGAAGGGTGACCTGGCATTAGCACTAATGATCACTTACAAGGACGACAGGCCAAGCTTAAGAAGATCTTAGACAAACTCTTGGACGAGAGAGCCAGACACATAAGCACAGACGCTGAGTTCTTTCTACTATCTAGCCGCCCAACCACAGCCAGCCAGAGGTCTCCTTCAAAGCACGGGGGCCCATCTGCCCCAGGGCCCTGCAACCACTGACCTCAGGCTCTGCAGGGCCTGCTCAACAGGGAGTGTGGCAGGGGCTGGGCAGGCCCACTGAGGGCTTCACAGAGAAGAATGGCCTGAGAGTTCCCACATTCCCCTGTGAGGTCTTCCATCTGAGGCAGCTTTGACCCCCAGGCCAGAAGGGAAGGTTCCTAGCCGGTTGGCATTGGCAGTCGTGAGGCTATAATGGACGGGGATGGGGGTCTCCAGGACGGCCTAAGAAGAAGCACACAGGCAATGGCCAGCATTGACAGCAGTGCCCCTGAAACAACATCGGATAGCTCCCGACCTTAAGCCGGAGACCACTTCGAGGGGCTGGGCCCCACCTCCTGGGGTCGAGGTCAGGACAGTGACAGCATTAGCAGCTCTTCTTCGGACTCCCTGGGCTCCTCATCCTCCAGTGGAAGTCGCCGGGCCAGTGCCAGTGGAGGAGCCCGGGCAAAAGACTGTTGAAGTTGGCAGGTACAAGGGCCGCCGCCCCGAGAGTCATGCCCCCATGTACCCAATCAGCCATCAGAGGCAGCTGCACACTTCTACTTCGAGCTGGCGAAGACAGTGCTGATCAAGGGCAGGGGCAACAGCAGCACTTCCATTTTCACACATCCATCTTCCTCAGGGGCCACCAGGGTCCTCACCGCAACCTGCACCTTGCGCCTTCGAGATTGGCTTTATGCCCTTGGCCTGCACAACTTTGTTTCTCCCAACTGGCTCTCACGTACTTATTCTTCTCACGTTTCCTGGATTACAGGCCAGGCCATGGAGATAGGCAGCGCAGCCTGACTAATACTGGTAGAATGCTGGGATGGGCACCTGACACCCCTGAGTTGCATCCCTGGCTGACAGGGCATCACGGGCAAGAGACTCCAATATGGTGAGGGCAGCAGCAGAGCTGGCCCTGAGCTGCCTGCCTCATGCCCATGCATTGAACCCTAATGAGATCCAGCGGGCCCTGGTGCAGTGCAAGGAACAGGAACAACCTGATGTTGGAGAAGGCCTGCATGGCAGTGGAAGAGGCAGCTAAGGGTGGGGGAGTGTACCCTGAAGTGTTGTTTGAGGTTGCTCACCAGTGGTTCTGGCTATATGAGCAAACTGCAGGTGGCTCATCCACAGCCCGTGAAGGGCTACAAGCTGTAGTGCCAGTGGGATCAGGGCAGCTGGGAGGTGGGCGGGTATGCTGAGGGTAGAGGGGGCCCAGGGACTGAGCCGGTTACAGTGGCGGCGCAGCAGTGACAGCAGCAGCCACAGTGGTGCCCGTCATCTCGGTGGGGTCTAGTTTGTACCCGGGTCCAGGACTGGGGCATGGCCACTCCCCTGGCCTGCACCCTACACTGCTCTACAGCCCCACTTGCCCTGTAGCCCTCAGTACCTCACTCACCCAGCTCACCCTGCCACCCCATGCCTCACATGCCCGGCCTGCCGTCTTCCTGTGCCCAGCTCTGCATACCCACAGGGTGTGCATCCTGCATTCCTGGGGCTCAGTACCTTATTCAGTGACTCCTCCTCACTTGCTGCCACTGCTGTGTCTTTCCCCGTCCTTCCATGGCACCCATCACAGTACATCCCTACCACACAGAGCCAGGGCTTCCACTGCCCACCAGTGTGGCCTTGAGCAGTGTCCATCCAGCATCCACATTTCCAGCCATCCAGGGTGCCTCACTGCCTGCCCTGACCACACAGCCCAGCCCTCTGGTGAGCGGAGGTTTCCACCACCCGAGGAGGAGACGCACAGTCAGCCAGTCAGTCCCCACAGCCTGCACCACCTGCATGCTGCCTACCGTGTCGGAATGCTGGCACTGGAGATGCTGGTCGCCGGGCACACAACGATCACCCCAACAACTTCTCCCGCTCCCCCCCTACACTGATTGATGTCAAATGGTTGCTGGGCTGGCAGCAAGCTGGGAGTGAACTACGTGCACCAGTTCTGTGTGGGGGCAGCCAAGGGGGTTGCTGAGCCGTTTGTGCTGCAGGAGATCGTCATGGAGACGCTGCAGCGGCTGATCCCGCTCATGCCCACAACACTGCGTGCCCGGCCTTTCCACCAACTGGTGCAGCGCTGCCAGCATGATACATGCAGTACATCCACCACCGCTTGATTCACCTGACCTCCTGCGGACTACGACGACTTGTGAATGCGATCCGGAGCGCCCGCAGCGCCTTCTGCTGACGCCCATGGCATGATGCAGTTTCAACGACATCCTACAGAACCTCAGCGCAGAACAGACAAGGAGCTGTGGCAGCGGGTCTCACTCGAGATGGCCACCTTCTCCCCCTGAGTCTTTCACCGTAGGGTCCTATACAGGGACCCAGGCCTGTGCTATGGGGCCCCTCACACAGGGGGAGTGAAGCTTGGCTGGACGATCATCCTCATCAGTTCCGGTAGCCCAGACTGACAGCTGCTCTTGGGCTGTAGCCTGGGGCCAAGATGTCTCAGACCCTAGAAGCCTAGGCTGGGGGAGACAGCCCTGTCTGGGAGGGGCGTTGGGTGCCTCTGTATTTATTTGGCATTATAAATATATAAACTCCTTTTTTACT + ('))(''#&()%%())''$((()%(&$##((%(((%((%(%(())&%(%(((%'$#((()''%'%%%$$(%)())(%$(%()(((%)($%(%''''$%)(,*),)*%&)&))&$(+,$),$'-,+)(+(&,#&(&$*#*+%,'(((-,---*)-(),-.*,(-(&)%.+.-,---(-,.-))),'**()$,,()(**'*-,.*(&)'#%#$''(()$$++,)))',*.,-.++)+,*+)&)-%)&$%+(),-+-).,**(+%,-'*))+*++.-,++,%,-,)'&&&'+-)*)$'(+''&,**)--,(')&%+,)()-,,.-%(+$*%+,)..,--,))&,$+,+&+%')*#+,)*(*')(&(&*,,*(+---,,-*-,-*,)(-,(,--,)&&(,('#,&,)"'),+%)'$'*+$&('(-+)'(((+&-')&++$&+,&),+++%%#)'+),+'+))*,#%#)--+-,()()-,,),-*+&)*)*-+,(((+---.-+)*'(*((++&,-,()),,&('$$)$,-(&)(),+(-.,-,,--*(-,*+(-+&(+-),',(,++&+-.,--*$*)$%.,)),*'&&&+*,%,&(+%*++),+,&('#,,#)-$)(+,*+*%((+',&*#'$#$$'-+-,'--,,-----()+.,*+,-),,)*-.+,))(*#&','(',-),+%(-.--)-,),+,$((((()---,,,*(+.+,**+,--),(+'&)#+&#%$-),-(+'-).---++(-+),-,&('()&$+,',-+'('%($&&(,,+&'#'%&'%#&#'()''&')%'(,*,#$)'(+-'%(*),)+'*'-**-+--,-(-')'&++&,,'(,-..---*,#$%$,-,*+(+($"$*+)+(*+,+,',)+(-+'('+)#)---'+'*&,---),//+)101/+*&,1/10-20/.&$'%/-$'*-0.011-1++',.-1,*(0.1.,*0.0.)+('$*+'+,-%'+((%'&##))()")$/1-11/,+,202..+)..01111210//1)0/0..'..111-+*12,-211011,&,,,01.02,.'01)00-/2.&&01-.,'(%(+0..'0.-*#./,1-*&'0,*,1-1/021+)/1.1.11+*-,2,0,+,0-(%%100-0$(/1.111-.*.0.11/),+)%0%),.+&-1,1+.,,,-*)*,/..,*02.1.00..%)((1*1(%%,+,*,-.2.*(*,+/-.2,+&(,+((01/11/12+.**+/,(,%+)&+.++%.+0(-+1-+-/+,&+/.%-,',-0.1200++11-0++-/.10*0/'1111-000'021)*0'01/2-0-,11002*-,+0**,01.1021,.+/..010-%+01-,,-1-1-/*-)-,-102.(*)#2.**/,,./.&./+.-/,-+-/+*--0%*+&+%'**//)0+*-+)&$&,+&+-.++*$,,*(-*0010,11,111100'11,.//&00*2/,$)#*(#-,./0-/+)/*/++(,(-)($+*+(1.11.-$#$2(1.114.05154/,2%25224,%*1.5/231563.00/0/42+,.%44454530).-'5650)(.-26151.31.-),*-/4)1321)45000+*/--*//3/0-&31/*6,515612/0+/105263640.3-)(1660400/120102//44,5355620054.$-/+$'02/65151453054+12525/50.-0..0)102*45-0///165654454-*0,/.&(0,,.++$*)256.(&2/*1654411*162.561+).5434+/3,-64510-/-.-,.&-0*/,*,).1+0.03*20-/4-(0+/2$),*.+6310*/-/+/./*%//.-(22002.4/'0,1/3*52/150+/4.623.-'-44.*2-2142-+5//-%.*,(%$-0'45/,450*04/1+/,/,("#)*+,*&%(&*+&0-*-,/3/$$$/1,,*,%-/(/+,6*.160'(0125((.(,0-5/.+%./45/*/',//)-4/0.(,,,(-(/+,1,/%22-%420*1/34)+(++.-02//0256226623004/055/-.*56-5--0'0.,.*+2-11.501/1065263.0,%3.*(02../$3//)&+'),$'(%#-*%(.45001'+0.2%4/3.1/0.2.)/*//+#('*0-0-/&5355--.)0'(&00(((//'(//*,+./40-*(%&%%#('*%'*%,*'*)).055/+-0-20,44-/0341-..033-.1/45(/2,100)05-//-./-02-,/.,).*52./,0(064/50-43545-145*5*2'%$*2(0'0104044/0000'4164645302/5/*+5-0*046102300/%-/&320..-,.2)%/4,1/41001/6150.,--,+3/,-*415.2/'0/0*-,/+41/55/**01-,).12.')%*/*40+50.'321+/3(1.4611.'4/$.,'302.**.452),240/-4210.)'*26644/)-/#(,,%-02$20-,$/2360,.$00.+2.,/0&)/1&.5/3/.1030//.12.$.-/*.,$(-+-003203446652/561/01/15*,56543142455-1.0.1+%/652244'30025(45)35/0641/0136/0+06565052401)42565146.13$.5134(431+**,0/,*-%544+35../54/164.,**0,.0+,4440+,--&.250511-)/+.#.),0'&/11,,11/0.+01$%&2/,121.--('+*+1,-,.&--111-'+.0//,+0-/.-%0-#/01--,.-*+/'2/+))-$),0.'+(,&*-,'&,1110.(12.&-(-(%*/)-/&02111+0,,1-/(0.-)122*'+0&++201.1,--.(&','(00./,*.*0,(',-)+,+,00-0/(..-$,0,/11.,,,)&-,*'010-1./&2-1/+1-10.+.(.)-,,1-,,1-),00/'2,0,,+.-2/+++%(*2-111-.+/-0+/.*00-(+)+,110-,'-0/.&.,02/&/-+-,%/2.,,#),-*(*--)-1.+',*''*+11..*00-0,2-,1.-,1+//,%,,*)0+011.-.-1-1-,)*-*(001//1+11.0)/.1,,+-1..--112--/.+-0*)%$,0,01-*,,)*(,)),+)*$$&+$')('&&*+)'&&#'+(),,+),%'$(%%%,,+%)**)'+,,)$+()%+++*'#',)'&))&+$(',--((,)-),,+)++(*--.+&',(*(*++))++)$$'(-(-,+++,',')---&$&#++-),)-,,-*())--*,)-,++-.,+-''%(*--'(,)$,+)#%--*(+,,(,)*+&,(+&#&##'*(+*()$++,')&#),)&)-)'%))*),)---+)-&)'%)'#$+',(+(+)(,),,-*,((-)(-$(*--'#+&(,,+((&(%&)()&,.-,-,)--,-+&%'#)+'-+----*((&%%+(,+)+',*&,-))','),)&,-*+&(-*-+,$&#&,-++),(,,&--*(+),+)-+-)+%",+)%%%$')('&#'#*)+)#('-,),)(,)(#(%,,)(&+,,('&)*---,-*,-(%,++''*))'('%,-%#',-,*(**-))&*$%*,-,$)**')#+,,(,-,,',-*$%(++,,)%*,+#+,&,,-,-,-,'(+--.-**-,,,,-.--#*)(',+,((,#'+++(&&"'*--*)-(&((((---),,*-,,++')))++*,--,')*'&$-+,(*($+'()--(--.----,'**&,&,&,++*(+&,-------''&%''-+()-*-$')*),*&%#+,,((#&*,,(,+-&')*%*%&%#%$()*(')'$%,.+-,-,-*'+( @rCer/773/0_1156_CCS TGATGAGGCGCATTCCAGGAGGACAGGGAGAGAGAGTGTTTTCATGATTGCAGTGCCTCATTTGAGGAGGAGCCAGAGCGGACAAGATAGAGAACAAATCTAATGAAGATGTGAATTCCTCTGAACTAGATGAAGAATACCTAATAGAACTGGAAAAAACATGTCGGTGAAGAGAACAGAAAAGAAGAGAAGAGAGCACTAGACTAAAGGAGGAGGAAATGAACAGTTTAAGAAAGGAGATTATATAGAGCTGAAAGTTCTTACAGTCGAGCCTTGAAATGTGCCATGCTGCTTCCAAAGGAGAGGTCGATCTGTTTCAATAGAGCTGCAGCAAGGATGAAACAGGACAAGAAAGAAATGGCCATCAATGACTGCAGCAAAGCAATTCAGTTAAACCCCAGCTATATCAGGGCAATATTGAGGAGAGCGAGTTGTATGAGAAGACGGACAGCTAGATGAAGCCTGGAGACTATAATCTATATAGAAAAGATCCATCAGTACATCAAGCAAGAGAGGCTTGTATGAGATTACCTAAGCAATTGAAGAACGTAATGAAAGACTAAAGAGAGATGTTAGGTAAATTAAAAGATCTTGGAACTTGGTTCTCCGACCTTTTGGGCTCTCCACGGAAAATTTCCAGATCAAACAGGATTCCTCTACCGGCTCGTACTCCATCAATTTCGTTCAAAATCCAAATAATAACAGATAACAAAGATAACAATAGCTTTACAAGCTGACTTGGATTGTGTGCTGCTTGCTGTTAGCAAGGGAAAGGCCTGCCAATGTTTAACTTTTAAAAGCATCTTATCTAAGAAAGGCTATCCAGTAGAGCCTAGTGCTCCCTTTTCCTCCTTATGATCAGGGTGAAATGTACTTCCTGATGTAATGAACCTAATTTGATTTCCATTTAAGGTGTGTCTGTGCAGCTGGTATCCGGTTCTGGTGTCCTATGTCCAGAAGAAGCCATTTGTCGAGGCTGACTTCCTTATCCACACAGACACAGCCCAGCAAAAGCCTCTCCTGAACCAAACAGACCTGTTGGTTGGAGACTGCCCAGACATGCTGATGACGGGTTCCGCTGCCTGTCCCTCCTGATCACACAGCTAACAGGCTGCTCCAGCATTTCCTGATTTCTCTGTGTATAAAGCTTTCTGTG + S'1311/6(2)))'-46+3)%/+#(/=96,'.%*??39%688;28;5*@;;-;@>%9>/58CD?9)@51F=-.B4,18@0A8<@E9,DA@>A9D7(E@<<<=DC>3H7A38BF2?)?+A>BI4*$>?E>9/(:4/>%BCB?/F>;?-IH9G;2;8BD06GE=IE6JA;G6DDBH0E0>E$FB/FF/GG4??035E>34'34,0<>A1GH@6I7:IAGBDDDE?A2E>BDAGI?BA5&F;C5=4A=>D6;*GE9?@=C=AFHID$-;F+@AB7??>GC=65E39,?0&?AB+ED@?G6@?@=-?>@8?@C@,@?8?B@B1E;EE8B:D(B@'?:;*328/%6<>--4>8%?CB(A67/F=<3<9%+8/C>1+13,8,A-7>2D50$6:<>BCE<0B>.H898(64:./('=3>4B<9%:;$GED=B6+.;CFA59;</=0.F?&G>9GJDE-GG8DH0)GE0%.9G16;4E=AG?'DB?H%<>DHFBF9:&J4B&;J,A6K.<1KH;)?*KIJ(E?1AE:7JCFBK'HIG-JH?KGEIJD4KHDCHKD5D-B==$?%B2D4H7CEJ;5;IHFF1E6JH+GADA&HFFE3E+II43J-2JHB?CK:JF3JK:.G)BC.H7?F<;D0K&J1G;GJ;K(@JKK&IFHJA'A2?KCI8C%>=*BC-F98H>6@;FG9>:A&D=C=5B)4%B?2KE:-D;%''K-DE=EG2/GHBE'E@?BAA?=EAIIII=<=5@F<+J+GE/=4HI6?&>&F>JHD;5%9@4IBHIJI8KJ43GD;JA9GC3KJHIJG92KHHJ<(=F(F3E@7'<)4.(-=)5(=5,.BDAEG0EFHI9KJ57/IJDEK9H'CA;2&1&>2?5J.HA?$J18C2@H'EG6-;BAG<%FI:G>88:IFAB2KE6@37FA;90FF?*DAHGG:;39;KJ8C7B65F3$;D?E<*3&40@G=@-IHHDGBE @rCer/774/25_1873_CCS ATGGGGAGTCAGTCCGGAGGCTGCGGCTGCAGAGGTAACGCCTGCGGAGAAACTGCAAGATGCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCCTCGGCGGGCCGGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCTCTAACACTCATCTTCAGAAGACTGGGACTGCTGAGATGTCCTCTATTCTTGAAGAGCGTATTCTTGGAGCTGATATCTCTGTTGACCTTGAAGAAACTGGGGCGTGTCTTAAGTATTGGTGATGGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAGAAATGGTAGAGTTTTCTTCAGGCTTAAAGGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGAGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGAAAGGGTCCAATTGGTTCAAGACCCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCAGTGCGGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAGAAGAAGAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCTGCCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCTGTTGCTGGCGCCGTCCCCTGGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATTGTTGGAGAGAGCAGCCAAAATGAAACGATGCTTTTGGTGGTGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTCCATCACTGACGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTGTCTGTGTCTCGTGTCGGATCTGCTGCCCAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTTGGTTCTGACCTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGGCAGTATTCTCCCATGGCTATTGAAGAACAAGTGGCTGTTATCTATGCGGGTGTAGGGGCTATCTGATAAACTGGAGCCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACCAAGCCCTGTTGGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAGTTCTTGGCTGGATTTGAAGCCTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAAATAAAGGTTCCATAATGTG + 34,5550334450(5/6146/$/1201,6151-1153621053/++444)101.,(%036426520365*32222+2..&*+/2.64/)1415133/540)..16,45&300555266562255430*34002*5/.35.445,35636554500461-,/%12-+211,0$-2+16464,13/454355-21/33.45/56351/562450655662355&25165/3631206//511,(,-,-+,+1.1-0)--.,.*..-..,(++2$-+,1(/-*+*-*252+.0$,-/&).550).0)425265/61)'220664164643*0',)1+05010/364(3-16522666+461342%36(34)4531115/5166412-.)//352253(-2+2)/2511131).11,/*3/5)2532113(43/366/43546+11201-.(-.115*/23.1532+25/165363136.3503.4250112*10,1.1535162650..222/.145.224'.00263/0&//32)++--'+03%0*,,146&0+.),(-/.3+555+4)12146465003)4&001-4544262.03,16+323/*.,0220+14.+220.)+'01-1/+345(03/+,$/.0+-/1*2'-*.0*3/402.6110546365,.554*30)1413420510426,5/0/#&(.//522/+6.6643641-2-502(0040//,,.-,.0(1,2+//.(-2/4203241*2/41641*231-0'.')-.*2&$&2-34346644364/--151,+/045345*41)542.-46/3,1/3/%0.-4.5166622556515656666241/1331+1.3/'0/--/0%,/2226.625135660/551144.'.2214))'0,.)*(./0*-&(0,1456512540.14366450416*/-4//3.41.)002/1+(//-/-.2*&*'(+/05.55/5445.,1440025.1666645&-/45020//$240*2056656145.1)1/455.2)&(#%)(.024)344/4665242*)300))+.363/12/-0/3,+153-342223*/465.26636)1/31541450.4+33234'))/.+)/4*./0(1-.23/220.54/214041/45.15/2-44-2++0/,04,$,,./0,+0)12.25265+1/0/.126144..+(,,20(/+1&,,20./-222-/250451224456/200.*2626625465604416246.41+3014-6*566665)4+3304554%1/231,/.(0)0%.0++(4775*2$#10514493541-*/2539;8(44524+31/0235603526.656/6,.1+33$,-/010-3(303+*'+4225)/...$11+-.000311340.2/56645651.346332&%+.-462460&+2+4,56664)*554665+33264,555/0-5534510/4222362523013044114&-/060.'1-3452./50,3+/(44-00&(*010)20/$-0013301/432,2656.03/.1333-/23,*34552,+2526/+1,4/.)02254123-/113)30*//)/*,4654+4145-150./10**+12-0405.454)/+/135.54.50/20414*&,/045.2666515.251.2.%2256422364105+&330)42/2**0.*%'/.0/222&*./434.)('13251,'3.%/-+0.-0,-).1.3343/34999;9::;0651978:4:991870:5965013693,06+469:9:867066998029117796946:77478;:75;::28 @rCer/775/26_1842_CCS ATGGGGCTCTCCTGTGAGACTGGCTGCGGGAGGATCATGGATACTTGTCTGCCGGCTTCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAGGAGGACATTGATACCCGCAAATCACAACAGTTTCCTGCGCGACCACAGCTATGCGACCGAAGCTGACATATCTCTACGGTAGAATTCAACCAACGGGAGAATTACTAGCGACAGGGGACAAGGGGTCGGGTTGTAATATTTCAACGAGAGCAGGAGAGTAAAATCAGGTTCATCGTAGGGTGAATACAATGTTTACAGCACATTCCAGAGCCATGAACCCGAGTTCGATTACCTGAAGAGTTTAGAAATAGAAGAAAAATCAATAAAATAAGATGGCTCCCCCAGCAGAATGCAGCTTACTTTCTTCTGTCTACTAATGATAAACTGTGAAGCTGTGGAAAGTCAGCGAGCGTGATAGAGGCCAGAAGGCTACAATCTGAAAGATGAGGAGGGTCGGCTCCGAGATCCTGCCACCATCACACCCTGAGGGTGCCTGTCCTGAGACCCATGGACCTGATGGTGGAAGCCACCCCGCGAAGAGTATTTGCCAACGCACACACATATCACATCAACTCCATATCCGTCAACAGCGACTATGAAACCTACATGTCCGCTGATGACCGAGGATTAACCTATGGAACTTTGAAATAACCAATCAAAGTTTTAATATCGTGGACATTAAGCCAGCCAACATGGAGGAGCTCACGGAGGTGATCACAGCAGCCGAGTTCCACCCCCATCATTGCAACACCTTCGTGTACAGCAGCAGCAAAGGGACAATCCGGCTGTGTGACATGCGGGCATCTGCCCTGTGTGACAGGCACACCAAGTTTTTGAAGAGCCGGAAGATCCAAGCAACAGATCATTTTTCTCTGAATTATCTCTTCAATTTCGGATGTGAAGTTCAGCCACAGTGGGAGGATATCATGACCAGGGACTATTTGACCGTTAAAGTCTGGATCTCAACATGGAAAACCGCCCCATCGAGACTTACCAGGTTCATGACTACCTCCGCAGCAAGCTGTGTTCCCTCTATGAAAATGACTGCATTTTGATAAATTTGAGTGTGTGTGGAATGGGTCAGACAGTGTCATCATGACGGGCTCCTACAACAACTTCTTTAGGATGTTCGACAGAAACACCAAGCGTGATGTGACCCTTGAGGCTTCGAGGGAAAACAGCAAGCCCCGGCTATCCCAACCCGAAAAGTGTGTGTGGGGGGCAAGCGGAGAAAAGACGAGATCAGTGTCGACAGTCTGGACTTAGCAAAAAGATCTTGCATACAGCTTGGCATCCTTCAGAAAATATTATAGCAGTGGCGGCTACAAATAACCTATATATATTCCAGGACAAGGTTAACTAGGTGGACAGTTATTACTTAATAATCTCACTACTGATACTAGTCAACAAGTTTTAAATGTTCTTTGGGTCTTCATTTGATGCATTGACTTAATTTCCCTATGCAGGAAATGATGGAATAGATTAAAAGGAGTCCAACATTCCCAGCTCCCCAGTTCTAAGAAACTTTTGTCAACCAATAGGTTTGGGACACTTCTGTTTAGAATTGAAAGCTGCCAGCTAACAGTAATTCTTCCATAGTTGACTTGAACTTCTGATGCTTTTATTGCCAGTTTTCTCTGGTGGGTCCAGTGTTTTGTTCCTAGGTGTCTGCTGCGATAAAATGAGGTTGTCTGTAGTATTTAAGGAGAAAAGAAATAAGTTTTTTTAATTAAGCATTCCATTTGATTGAAAAAAAACAACAAAAAATAAACACCGTTACTC + **'1//()+...100+&$$1,163123$11.#4/253&+6/54++-,/1*12346545663612.61,5451630&)../+,/+126265021+,012.03*32)0302544'11/.$*.6443+331542+355&(-+31*302-/4122624612.111&$))150./1/4$)*%/&/3,/'),,//4320)-08.20*6823.+-9:95365&4/8.2,230031/12-&347897--,.990.6*0/44&0/111.5:.95/4461/&67)113,630744,:632*/.30(37:;8559358:9(-+73425(6994591+265-9.*-,8815(358020:4'7871/5/85&1/00,6-044:67'7543291173:557474,1543::9985*-203505275524%53/17/8.777,14(4+20:8767::9557313/#15-74:74,5/3)-/3,.0/32-76134:95:9'35755:4/-51.4-146586733:974,-&359399397.0+88424624%+6&740400826553/89624%035:8/672+4--7876395:52*.'/531-3-'-.*-2/51768:5:943;88374773:2994343498975,54352.01873599..:::75-6&&1;,255:53867/6186(744/:74.367*779%761#0--)044469666-4411+5,-663+6'65266;85:3-3463:0753;:757956-5:93666%1-6+7,%45556-22.3746::8+3+9776539:1639:5298%5347;06697:79;389121475.0+,353670/*1*5989/0448:715695868+91%7261-/36/1.3,63852115.:,'18898.262%25.1307/5%/.3825411122:-535:6::63725,/76043;7::62&24..0$0059,/44.4&*666954(3650194,5.57:3-+%820'595925746/799+07.:9912/52.82693(5748,4-.7:3503.:9768:7970668'755-73:7-80.)2*97540410964+:3:952(67.882/...,&++/*349:2;:32---8&79754(5560599,87165:-,2)57&0656809935:9/8*36:877:69849.9+8797/3533,,,$+')/'-*1*.,//,0.2*00)0,*)**,..0,$-+),*+*$&-+,*#'++).-,&'*.0.21.221-0,-/'1-%.,-,11')/...%.01(&+,001'-0&/*+$*&.,'/,,)(+%),0/-.1)+'-*$,-111().+0,*,&*+*,%##$&$(0,/')-,(-01..',+-/,,0+%-..*&)*1,00)./0*(,.*-.2/+/-+0'/,*$--/,,10/%,$-/+/).,++*&)-)**),.,)+00&/+'()&0-*$)./0'1'*,-+/.++)0/0&*+)./000%())2$3--)./$//%/015210'-002'%/5(22/3$%-&,.13603.)314/.+4365+3/+012013&0.'.11/43/%-.-*)%&+#(-//533&*%%.((-2+,,1550.%1,25-0+)20..15.420,/.,+,*.(10+.'-(-)+.*'040/*-1520.5111210.%0//1)21$.--%-/1))-142*055012.*,1'.-04/3',++%/'+/),440000./)-1/,*)/.(-.+)...+/*),3/+-262/-3433-4+/'2/#++-,&##'//-023),1*43(/3/4043%0343400,-50#/0-00.)55.*,5.$2-.41 @rCer/776/25_1480_CCS ATGGGGGAGGGGCGGAGCTGGGGCATGGCGTCCGGAGCGGCTCGCTGGCTAGCACTGGTACCAGTCAGGTCCGGGGCTCTCCGAAGCGGTCCTAGCTTGAGGAAAGATGGCGATGTCGCCGCAGCACGGAGTGGCTTAGGCCAGAGCCTGGTACCGTCGAGATGTCCTTGGCCTTCTTCGTGTGTTCTCCATTGTGATCCCTTTCTCTATGTCGGGACACTCATTAGCAAGAACTTTGCTGCTCTACTTGAGGAACATGACATTTTTGTTCCAGAGGATGACGATGATGATGACTAACAGGCATTACAGAAAGGAGAAAGCAGTAACTGAAGAAATGGTGATGCTCTCAGCTTCTCTGCCTTCCCTATCAGCAGAAGGGCTCAGGGAAGGCCCTCAGCCTCCCAGTCTGGTGAAGCTTCCTGTATGGTCCATGACCATATCCTACCCCAGGCTCTGGCAGGCTCCCTGAGATGTGCTGTCCACTAAGCACTGCACAAACAAGCAATCAAATTATGAATAAACATAATAATATCAGCTGTGTGTGACTGAGTGATTGCTGCAGTTTCTCAGTATGCCTAGGCTCTAGTTGGTGCGGTTGTTTCTGCTGTCCTTTATTCATGAGAGAAACAGGCCCAGGCTATCCAGGCTGCAGTGGAGCCCGGTGAACTATTCTGGGGCCTGGGAACGATTTCATTGTTTACAAAAGCCCAACAGAAACTGCGCATTTCCCTTAAGAAAGCTACATGGCCTAACTAAAGCCTCATGCCATTCTGTGTTCAGTGCCAGTCATTTAAGTAGTACGCTCTGCTTGTTAGCATACTACTTAAATATAACTAGAATGATTCAAAACTTGGGTTCTGTGATATGAGGATATATATAGGTTTTCATCTATTTCCTGGCTTATAACTCCCAAAGCCCTTGTTTTAGGCTTTTGTTACAATGTTGGGCACTTTGGGCCTCAGAAAACAACAGTCTCTTTCTCAGACCTTCTCCTGACCTCCTTTCACCTGCTGCTTTTTCTCCCCAAGGCAGGCCATAGAAACTAAAGTATAATCTTCCTTTGCCTGTCTTCGAGTTGGCCATAAAAAGAATTCTCTGACCTACCTTGTCTGATTTTAGGTCATGAGACCCCATTTCAGAAGGGATTCTTCCCTTACCTGGGAGGAAGAAATGTGGACAGGCCTTGTTGGACTTCCCACTCCATCTGTATTAGATTATGCCTCTTTTGTCTACTCCCATTTTTCCACCGTTGTCCATGCTTCAATCATCCCTATCCAATGAGGTCTCCATAAAAGGCCCAAGAAGACACGTTCAGAGTTTTCGGAGAACAAAACACTTGGCTTGGAAAGTGGCATGCCTGGAGAGAACTTGGAAGCTCCATGTCCCTTCTTCTATACCTCACCCTATGCATCTCTTCATCTGTATCTTTTGCGATATCCTTTACAATAAACCAGT + FE#IJE?@)HJKKIK0DE>%KHHAJE6KKHI>>B=BF>KF<8K?I??J4HACK)KKKJJBG2JK=J4H-@JKKF?;64KKK)K(KCAI-*@8DE?EBHFCEAE@I@CFJKK7KAF?H<5GHH'KHCI6DGA?HKIKG@KJCKG9KKKKHKKJGJ:JFKJA6JBKKJIHKKJKBK;KJKJKJFJE@ADJ;KKKKJK&KJ9K;KEKKJKKI6KH4JKEHD@53K8HKDJ)KKKB/KKKKK?KJEJK6I.K:=KKAKI@K<'K9@JIJJKJKICJ?FEKKKJGIKKK9FFGKJKAI2KKHJKJK8K3E@KJKHKKJKFICFKHKKKKECCKJ1KKKKKKIKKGK?KIK@DJJF9FC;@5GIIK7K-KKKKKJJ=CJKK=KKKK;KKGK4KKKKKKKKJ&KK:KKKKJKK-KKJKKKKKK?K1?IF:KEKIKKKKKIKKHDKKKKH9KDKJKHD*KKKKH1HJKK@JFKKKKKKFKJKJKKKKJ(KKICDKJIJIBDG8)KKKA(KKE@J0K4KK=EKG#K#8I9J@(KD/KKKHKAKK>KKJIKKKKKKKKKKDKJGKFKKJ<>)KKKAK4IJJKIHAJEKJKKGKHGK:KKK7KKJIJFKJCH6IKB:KKKK8KDJKKGKKKJKIKKKAKK4KJKKI.KK?KKKKJKKKKKKKKBGKKKHKKKEKKH(JKIHJIHKJKK&KAK@KKKJBKIKKKAKJIKBKCKBK@GKKK;KKJIKKKKKKIKKHKKBKKHKKJ?KKEI5KJJKKGJJJ>KKIKKKKHKKKKKK5KKKKKKJKCKGKCKKKK4KKDKHKKKKK @rCer/777/25_2020_CCS ATGGGGCAGACGCTCAGGGGAACATGGCGGCTGCGGAGCCGGCGGTCCTTGCGCTCCCAATAGTGGCGGCGTGGGCGCGGGGGCGCCGTCGGGCACGTCCCGGTGCTCTTCTGTTTCTCTGTCTTCGCGCGACCCTTGTCGGTGCCGCACGGCGCGGGCTACGAGCTGCTCATCCAGAAGTTCCTCAGCCTGTACGGTGACCAGATCGACATGCACCGCAAATTCGTGGTGCAGCTCTTCGCCGAGGAGTGGGCCAGTACGTGGACTTGCCCAAGGGCTTCGCGGTGAGCGAGCGCTGCAAGGTGCGCCTCGTGCCGCTGCAGATCCAGCTCACTACCCTGGGAAATCTTACACCTTCAAGCACTGTGTTTTTCTGCTGTGATATGCAAGAAAGGTTCAGACCAGCCATCAAGTATTTTGGGGATATTATTAGTGTGGGACAAAGACTGTTGCAAGGGGCCCGGATTTTAGGAATACCTGTTATTGTAACAGAACAGTATCCTAAAGGTCTTGGGAGCACGGTTCAAGAAATTGATTTAACAGGTGTAAAACTGGTACTTCCAAAGACCAAGTTTTCAATGGTATTACCAGAAGTAGAAGCAGCATTAGCAGAGATTCCCGGAGTCAGGAGTGTTGTATTATTTGGAGTAGAAACTCATGTGTGCATCCAACAAACTGCCCCTGGAGCTAGTTGGCCGAGGAGTGGAGGTTCATATTGTTGCTGATGCCACCTCATCAAGAAGCATGATGGACAGGATGTTTGCCCTCGAGCGTCTTGCTCGAACCGGGATCATAGTGACCACGAGTGAGGCTGTTCTGCTTCAGCTGGTAGCTGATAAGGACCATCCAAAATTCAAGGAAATTCAGAATCTAATTAAGGCGAGTGCTCCAGAGTCGGGTCTGCTTTCCAAAGTGTAGGACATTTGAAGAACTGGTATGCTACCCACTGGTGAAGGACAGTCAGGTGAAGGACTGCAAGCCCACACAAGCTCTTCTTATCTCTACTAGAATTAAAATGTTAAGTCAAAAATGGCTCCTTTTTTGCGCCTCTTTAGTGAAACTTAACCAGCTAGACCATTTGGGTACCAGCATTTAGTTACAAATGTCAAAGGCTTCTGGTGCTGCTTACCTTCCTTTTTTGTTAATGTGCTTTTATTTATTAAAAAAATTATAATGAAGGTGCCTGTTTTGTCTATACTGTGTACTCTGATCGTATCTTTCAAAAGTGCAGACTCTTGTGAAGTTTTCTTAAATTGTGCACTTTAAAGAAATGAAGTACCAATAATGATTTCACTTTTATATTACTGTAAGATGTTATATTGTTAATGTGGATGTAGTGCTTACTTTACAGATTGATTGGAATAAGATTATTATATATGAATTTACCCACAGGACTCTGGATCATGTTACCCACTCCCCTCACAATGTTGTCCACTTAGTGAGTTGCATTGATGTATCCATACCAAATGATGTTGAATAATTACATATCTTTCTTGATTACACCGATTTCTTATTTCGGTCACTGTTACTAAATCTCTGTTAATGTTCTGTCTTTTAACTGAATCTTTTACCGAGAAAAGCTCATTGGATCATTGTTTAATTTTGTAAACAGATGGGATAGAAGGGTTTGCAATGCCATATTATTGGTGGAGGGCTGTTTTAACATCTTTGAAGTATGACTTTAGCTGAGTATCTTTACAACCATCTTGAATATGTCTTCTAGTGTCCACAAGATTTAGCAAAAAGATAAAGCCTGGGTAGAATATCGTTTTAAAATGTCATGTTCTGTTCTATATTTTCTCCACCTGCTCTCCAAATATTGTAATGCAAAAAGTATCAGTAATGATCTGGTAGTATTAATTTTGTGGTCATTGTTACTCTTCGATACATTTTTTTCGTTAAATACTTATTAGAGGGTTTTGAAATGTTTTTCAAATATGTGAAATGTGGAACATTGCTGTCTTTTATATTAAAGTAATTAAAATGTATTGTGAT + 643>?>841<>8;7=4*04<9>26709:0769><8967,96;8;9;=?26984/.'286=523506826813'/1374.=>>>57787172>>941#327<5;5::8825//823998864992;5*(69715275<02717<85=<>9=:?886.=46771:>><;:4.84(,73846277:;;=<923846*4/20977>69>55:::980<1;><7/8884>9;7=2::88=88788=075>4:;>;'=550=:8<692;;152<=9>>.044?6164876987<26748=23;5=1;157/8429<;>=49<=97=<6<>77><88:>3930:>-9-8;7;?=45;456309=:,409:7889/+34687>?>97::218023276/:85=/864959>2;2==:247312.:==2>?;;<>*:=.978778-7888.3:;;4=:<9*0./2<>:5882887=79;,92=8248<93:566885986427234/+24;859<;;837<-8894<36-89;45<7:??:?>8.<18;555959/+./1561/777040867;72.4$//*/8873:9391+.48354.+84+142-1*+272/665445301.6'3-/787637/)6400(1+-),-,./539432/7)42555,2755:4-87/9/62(-.062&4325/:4857493:7;4;:87:4.488/302553516506:78635/5.465:-641/223'730679:6541169:745-895.85445656::8-45:971-0*(6:991359498:/4443302599053,4349945442155354267485028;/261807-7)971-03/:/98;;7:563084220.366:7;::84/9::8;8151/95;;:7:551454427772/,58;:54(422/40,412+358607'*,220*,204416,65340053110.-0160,/25/4500.1//1$3,./-165-+.4.46665.-+',.1*10,))).064)+$,+55416404605066+266,1&,%-055140/446656,0465+40/*43%,(.464.-3-252).0,'$.02/35155*)%2565154/36565413-2513,113./01310.4531.,44)-23+-16615)301113.%/+,/435626235635*11445414//2435/463.0121-*35330*442*5423*032301,443665014&00/-46/16025*44161540211$,113%(36503140353632320010666551360.0)0,.4411)/242*4.01165434641652/652.4,43666615416651626461+131145-50/.25.3$4,453-52325,33430.26533//.-4.%.',,(%,-++,,&,20-/5/5351556-3651300/36665-362///545)01#,'*0,/))42(20/4$,354-434052/)34./3212-450(144435/42023(*,02.,4/20-20445/..*/--)((31/01,)455+4/./4622*0..-).//1(14444*051121050/.42-5536+4651+&+44.4*1+665//'25.65'432416102465,,1036230%,4&023).,1023412661553-/40.)032++02202630-1/0/10335536663/44/2.2123..341/2.3+&21,/,2.+54054'2231+1)*0321444553512/14,.+&+//)-1-0/#165-/35+4*.,2.*1)51,)1/-1165002521/*4/-2&*+0&-/460633552/5631316662.25*-3/2-0/156022122./+42)5/*552'*),6651662+24451..42556632556024553(43(2044/12(+-1553-36.41(/4646365-255664,2.22603$1+(,13./162/.'0+3(444.5/55652221 @rCer/778/25_1878_CCS ATGGGGGCCAAATAACATTGTTAAAACAATGAGTAAAGAACGGAGATGTTTCTTGGTAAAGGAACACCAGATCCAGGAGCAAAGACCCAGAAGAAGATTACCCCAAATTTGGACTTTGGATCAGGACCTAGTAACATTGTCCTGCTTACGACAACCAAAAACAGAGCAGTGCTGTGTCTACTAGTGGGAATCTAAATGGGGAATTGCAGCAGGAAGCAGCGGAAAAGGACGAGGAGCCAAGCGCAAACAGCAGGATGGAGGGACCACAGGGACCACCAAGAAGGCCGGAGTGACCTTTATTTTCTGCTCAGCGCCTCCCCTCATGGCTACCCCTTGGAACACCCGTTTAACAAAGAGGGCTATCGGTATATTCTAGCTGAGCCTGATCCCCACGCCCCTGACCCCGAGAAGCTGGAACTTGACTGCTGGGCAGGAAAACCTATTCTGGAGACCTCTACAGAGCCTGCTTGTATGAACGGGTTTTGTTAGCCCTACATGATCGAGCTCCCCAGTTAAAGATCTCAGATGACCGGCTAACTGTGGTTGGAGAGAAAGGTTACTCTTGGTGGGGCCTCTCATGGAGTTCGGAAAGGTGCCTGGTATTTTGAAATCACCGTGGGATGAGATGCCACCAGATACCGCTGCCAGACTGGGTTGGTCCCAGCCCCTAGGTAACTTCAAGCTCCTTTAGGTTATGATAAATTTAGCTATTCTTGGCGGAGCAAAAGGGAACCAAGTTCCACCAGTCCATTGGCAAACACTACTCTTCTGGCTATGGACAGGGAGACATCCTGGGATTTATATTATCTTCCTGAAGACACAGAGACGGCCAAGTCATTGCCAGATACATACAAAGATAAGGCTTTGATAAAATTCAAGAGTTATTTGTATTTTGAGGAAAAAGATTTTGTGGATAAAGCAGAGAAGAGCCTGAAACAGACTCCCCATAGTGAGATAATATTTTATAAAAATGGTGTCAATCAAGGTGTGGCTTACAAAGATATTTTTGAGGGGGTTTACTTTCCAGCCATCTCACTGTACAAGAGCTGCACGGTTTCCATTAACTTTGGACCATGCTTCAAGTATCCTCCGAAGGATCTCACTTACCGCCCTATGAGTGACATGGGCTGGGGCGCCGTGGTAGAGCACACCCTGGCTGACGTCTTGTATCACGTGGAGACAGAAGTGGATGGAGGCGCAGTCCCCCGTGGGAACCCTGACCAGGTCCCTCTTTCTGTCAAGGACTTTCTGGGGAATAATACTGGGGGTTTTGTTTTTGTTTTTGAACTGTCTCAAATGTTCTCCCAAAGATGCTACAAAACACAGCCTCTCCTTTTAGCAAGTTAAAAGGCTGGGTAGGACTACGGAGACTGCCTGCCTTTCACCATTTTCTCCCAACTTCCAGTGACTGCTCTTATTTGTGTACCACAAGCCAACAACCGCTGACTCCAGGATTGTGTAAGCCCCTGTGAAATCAGTGCTGTACTGCATACCCTGCAGCTGTGACTTGTTTTCCTACTATATTTTCTAAAGAGTGAATAATATTGTCCGAGTAACTTATTTGAAAGACATTTCCTTCTGTGGGCATTGACTCCATCCCACCTGTTTTCCAAGGAAATGGTAACCTGTTTCTGAGAACACCTGAAATCAATGGCTACACATTCCAAACCAATCTAAACACTATTTCCCTTTGGTGTGGTTTTGGTTTTGTTGTTCATTTTGAAATATACTTTTGAACACTGAGATCCCTAAAACTACTAGATCTCTAGAAGTGTATTGTGAAAGAAACTTGCTTGCAGCTTTAACAAAATGAGAAACTCTTCCCAAATAAAACTTGTTTTGAAGTTTGTGTG + 1/$///-.1%*,0-10/01-$.*0/1.,1011/,,111..0$),00*-*%'.).,/-(/-+1+..#$.,,01120$0.00&++/,,20-0-2-)0,,-100202+11*0.+*0+%10/01*-*+10+%%),($+/0.*#)(0+--+0-10,,+0''$0/+-)+''/1--).1,/)001*,.--,/*1/*0+.*,22-#&,,,1&*-(+,0-02.0.0011'&(011/2/10-*.'*+,'0/-,/(-*,*/11,.',-21,221/-000+10+&--(.,0,,-),'.*)-.11,'1*011,+/011-,/10'/,+/#$*,/-(-%*0-,0&..0&+$**1//(-',+10*+-'-00/$./10111,11-11-2&.1.1-010*1+-,'(11/,01&11-.11)10100,'0110/2,0/)1**(),0'&*/0102-10102%&&$$...0.---)(,,.11.1&,)/+*10.01112+&0/-101,,1,.,21/1+,,+011111/++.-211,102211.100111.-'.202*)&./1/0'/*1,,0.1-,11*+&,,*'+%%.21*%),/0-,111.*0/11/1./0.0121102*/2.0&.../&0,(,-&/-+'--.)0+//&%*11.21010*$..+)/+1,--//*21++-.0,01+,,221-0..1/1(/00$0))+*.+02,1202).1../22,/1000-0-..02*1-.2100%-./&/0)-,.02.12)-&(1//0,2**1/2.-1200-./0,*,1*/02,011+'*),(-1,/0./*..,)/0-%.0&.&')$,),21211.2,*&)-01,-(/(-*.,1/111+10-2&.1.10-,.*,01-1-/2-00*0/-0.&*/..20,11&102*'-000.,110/-//+011111.1-,'/-20,(111111-.02*.+,1110221111&+*,1101/0**/--+*.0-)/20,-+011/,)11010+111/2,101/-1((//.+11/1-/+111..*(-110,11+'(),)-0012-'/***)0/-+/+.,&/111/-,02+11-1)+.121,11',/.0-/-*'./(.,-/0/0,*+,02*/1-,/.1-*1/.1/&.*(//.-+,*&,1*,1111).0,-/*10,.0&'&+0***-),.%&0*,1111++(.,*./10'-2+5225655.2(211*+%3$,.30//--,16650446515(.0115132)//*4-2+$4543/0646%-/4.6/--&244.5446.+/+'021006431&242.0*30354/33.450*0.25-+.31-/36166125304/4(0/0-03.026.**.1/264364.,210&121/602+51.*.650522&),,,2,51311.224656322(214/)'1336*36*5./10363436536/$1406550*4./56516,655656236653-'44161266450465'22545/50254224,4665015132/35,5,0/%24613/255+30+($$'0335*54.0536354565.435,4/,132/434+3331444*262266506211/*,12(3&23665+65433/3/260630164536242666.1-3362666561.6)1&0*453*163/04*2510'0045.65+54255.25%/.2+1421.0541*5122.4.164166,3303111&4#+-$$-%-//.066.20/#-133,144300,+2440+345212&/34*423)3322/3/1-3506/,*+21,/-4+(*04-0144.0662.344+115435)/)(4-)55325/.,5400026116-130&233*,65(+556665,0.-3544 @rCer/781/25_2007_CCS ATGGGGAGATGCCACACTCGCTCCGCGGTTCGCATGGCGCTCTGAAGACGCCGGCGCCCGCCGCCTTGAGGAGCCGCTGCCCCCGCTCCCTGAAGATGGGGGAACAATGAAATAAGCGAGAAGATCCCGCTTCTCCCCCCTCTCTCTCTTGCCCCCTCCCCCCTCCCTCCCCTCTCCCCTTGACTCCTCTCCGAGGCACCATGCTGACCCGCCTGTTCAGCGAGCCCGGCCTTCTCTCGGACGTGCCCAAGTTCGCCAGCTGGGGCGACGGCGAAGACGACGAGCCGAGGAGCGACAAGGGCGACGCGCCGCCACCGCCACCGCCTGCGCCCGGGCCGGGGGCTCCGGGTCCAGCCCGGGCGGCCAAGCCAGTTCCTCTCCGTGGAGAAGAGGGCCGGAGGCCACGTTGGCCGAGGTCAAGGAGGAAGGCGAGCTGGGGGCGAGGAGGAGGAGGAAGAAGAGGAGGAAGAAGGACTGGACGAGGCGGAGGGCGAGCGGCCCAAGAAGCGCGGACCCAAGAAGCGCAAGATGACCAAGGCGCGCTTGGAGCGCTCCAAGCTTCGGCGACAGAAGGCGAACGCGCGGGAGCGCAACCGCATGCACGACCTGAACGCAGCCCTGGACAACCTGCGCAAGGTGGTGCCCTGCTACTCCAAGACGCAGAAGTTGTCCAAGATCGAGACGCTACGCCTAGCCAAGAACTACATCTGGGCGCTCTCGGAGATCCTGCGCTCCGGCAAGCGGCCAGACCTAGTGTCCTACGTGCAGACTCTGTGCAAGGGTCTGTCGCAGCCCACCACCAATCTGGTGGCCGGCTGTCTGCAGCTCAACTCGCGCAACTTCCTCACGGAGCAAGGCGCCGACGGTGCCGGCCGCTTCCACGGCTCGGGCGGCCCGTTCGCCATGCACCCCTACCCGTATCCGTGCTCGCGCCTGGCGGGCGCACAGTGCCAGGCGGCCGGCGGCCTGGGCGGCGGCGCGGCGCACGCCCTGCGGACCCACGGCTACTGCGCCGCCTACGAGACGCTGTATGCTGCGGCAGGCGGTGGCGGCGCGAGCCCGGACTACAACAGCTCCGAGTACGAGGGCCCGCTCAGCCCCCCGCTCTGTCTCAATGGCAACTTCTCGCTCAAGCAGGACTCCTCGCCCGACACGAGAAAAGCTACCACTACTCTATGCACTACTCGGCGCTGCCCGGCTCGCGGCCCACGGGCCACGGGCTAGTCTTCGGCTCGTCGGCTGTGCGCGGGGGCGTCCACTCGGAGAATCTCTTGTCTTACGATATGCACCTTCACCACGACCGGGGCCCCATGTATGAGGAGCTCAATGCGTTTTTTCATAACTGAGACTTCGCGCCGGCTCCCTTCTTTTTCTTTTGCCTTTGCCCGCCCCCTGTCCCCAGCCCCAGAGCGCAGGGACACCCCCACCGACCCCAGCGCCGGGCGCGGGGAGCGGGCCACCGGTCCTGCCGCTCTCTTGGGCAGCGCAGTCCTGTTACTGTGGGTGGCCCGTCCCAGGGGCCTCGCTTCCCCAGGGGACTCGCCTTCTCTCTCCCCAAGGGTTCCCTCCTCCTCTCTTCCAAGGAGTGCTTCTCCAGGGACCAGTCTCCGGGCGCTCCCTGGAGACACCCCCTCCCCCATTCCCAATATCTTCGCTGAGGTTTCCTCCTCCCTGCAGGCCCAAGGCGTTGGTAAGGGGGCAGCTGAGCGATGGAACGCGTTTTACCCTCTCATTATTATTTAAAAACAGACACCCAGCTGCCGAGGCAAAAAGGAGTCAGGCGCTCCCTCTTTCTTGAAGAGGGTAGAAGTCAGGGCGCCGGAGCCCGGGCCTGGAACGCCCTCACCCCAACCTCCAGTCTCCGCGTTTTGCGATTTTAATTTTGGCGGGAGGGGAAGCGGATTGAGAGGAGAGAGAGGCCAAGAAAATTTGTAACTAGAATCTGTTTTTCCCTTTTCCTTTTTTTAAACAAACAAACATAC + KE%IIFIHEKKEKHKJJKKKKIIKKKDEDKKKKIIKKKKKHKKK>KKKKKJKJKKKBKJKIKKJFGKKKKKIJFKKKKH3KKKKKF8'HJJKKKIII4KCKKAKJKJKKIKKJJKKKKKE@KKKKKKKKKKKI?KKH?KGGGKJGBKJEIACKHCKJ>EEBFKKKK>KK5KK8JJKKKKJKGK*KKJIKJIGKK;KKHBIGKCJE>KKKKK=KKGKKDKJ@KKIKF3KKKKJKKKKKKKKKHKBKKJKJKEKBKEIJGKKJKCKKKFJKHKJKIJGKHKEKII/KJIKKKEK>EJIJJJKJKFACJJKKKKIDIJGEKKKKKK>KKJDKHKBKKBAEJFKJKKKH:KIJJAKKKHKJKKKKK2JKHKJKIIJBJKKKKI@JFHIIHKJC@DK7HKKKBJJK6KKIKKHJBKADECDJDKKJKKEKKFKJJKKKKI6KJKKHKJHKDKHKJ+J%EJJGIAKKKGCI8KKG8KAH%KKKJAJC=JKHHH'JJCGKIHIKKIFKKJKK%HIKKKKKJJ:KKKKKJKDK8KKJIK(KKK9KK?KKAKK@KKJEKKJ8=)KIIJJKKKHKKKKJJ7KG(JFFI&IKKIE&KKEKCKKJFKKBJKJKGHKGK:KAK@HJKKHKKKKKKIKKC@JEEBJBDK%JKKKKK;KKKKKJIKJJ*KKKK4,CKJKDKKCKK>KKH@JEKJKKKJJJJJKKJJJGKJ6KKKKKKIK2KKKKGKJEJJKKIKKKKKFKJKGH8HKCG.KKI@KKKKKJ7KKKKKKKHKKJ@KKKKDKKKJKCKK&KK6KKAK6KHJ:KKKIA&KDKAKKKJKKHKKKJGKKKK+KKKKKKH1JKB>I6KKKDKK.KKK,KKKEKKKIKEDHJKKHBKIIFIIJJCJGKAIJ1KKI>HFEGFGIFHF?IFEF@%AF<27IK;JKKAJ*CJKKJF?GKK3KKF*JKKDHIJ @rCer/783/25_1824_CCS ATGGGGACGCTGAGCTTTCAAATTAGATTACTTCTCCATAATATTCATTCCATCGCACTATTCATCACCTGGTCTATTATAGAATTCTCACTATGATACATAAACTCAGACCCAAATATCAAACCAATTCTTCAAATACCTCCTTATTTTCCTCACTGCCATACTAATTCTAGTCACTGCCAACAACCTCTTCAATTCCTTATCGGCTGAGAGGGCGTAGGAATCATATCTTTTCTCCTAATTAGCTGATGATACGCTCGAACAGACGCTAATACAGCAGCCATCCAAGCAATCTTATATAATCGCATTGGCGACATTGGTCTTATCCTAGCCATAGCATGATTTCTCCTACATTGTAACTCATGAGACCTCCAACAAATACTAGCCCTAAATCTCAACTCAAACCCCCTCCCACTAATAGGCCTCCTCCTAGCAGCAGCAGGAAAATCAGCTCAATTCGGCCTTCATCCTGACTACCTTCTGCCATAGAAGGCCCAACTCCAGTCTCAGCCCTACTTCACTCCAGTACCATAGTCGTTGCCGGAGTGTTCTTACTCATCCGCTTCCACCCTCTAATAGAAACCAACACAATGATTCAAAATCTTACATTATGCCTGGGAGCTATTACTACCTATTTACAGCCATCTGTGCCCTCACACAAAACGACATTAAAAAAATTGTAGCCTTCTCTACCTCAAGCCAACTAGGCCTAATAATAATCACCATTGGCATCAATCAACCATACTTAGCATTCCTACACATCTGCACCCATGCTTTCTTTAAAGCCATACTTTTTATATGCTCCGGATCCATTATCCATAACCTAAACAACGAACAAGACATTCGAAAAATAGGAGGCCTATTCAAAACAATACCTCTCACCTCAACTTCCATAATCATTGGCAACCTAGCACTTACAGGAATGCCCTTCCTCACAGGCTTCTACTCCAAAGACCTTATTATCGAAGCCACAAACACGTCGTACACCAACGCCTGAGCCCTATTCATTACTCTCATCACTACCTCTCTAACAAGCGCCTACAGCACTCGAACCATCCTCCTCACCCTAACAGGACAACCCCGTTTTCCAGCCCTAACAACATCAACGAAAACAACCCCACCCTACTAAACCCAATTAAACGCCTCACAATGGGCAGTATAATCACAGGATTTCTTATCACCAACAACATCCCCCCACCTCACTCCCCAACCAGCAATACCCCTCTACCTAAAACTCTCAGCCCTATGCGCAACTGCCCTAGGCTTCCTAGCAGCCCTAGACCTCACCCTTATAACAAACAAACTGAAAATAAAAAACCATCACAAGTATTCAAATTCTCCAACATACTAGGATATTTTCCCACCACAATTCACCGCACAATCCCCTATCAAAACCTACTCATAAGCCAAAATTTAGCCCTTCTCCTGTTAGACTCGACATGACTAGAAAAATCTATACCTAAAACAATCTCACAAACACACATCACTGCCTCCATAGCTGTACCACCCAAAAAGGCATAATCAAACTCTATTCCCTTTCTTTCCTCATTCCCCTCACCCTAGCCCTAATTCTAATGATATAACCTATTACCCCGAACAATCTCAATCACAATATACACACCAACAAATAGTGTTCAACCGGCAACTACCACAAATCAACGCCCATAATCATATAAGGCACCCGCACCAATAGAATCACCCCGAATCAACCCTGACCCTTCCCCTCAAAAATTACCCAGTCACCAGTATCACTAAAACTAACCACCACTACTATCGTCTCATCTAAACTTAAAACCCAT + .--79:65698888:(999/715845,*7.,'53325538:424;79+*-/(557710575425/16'34/8176:35,//)15+953577388:820866/7:3364<489;48.0-46&246<4<3=9547.45694:<8:5;:4;;77:=>:;76:9:50+618.61>:;97=87;6=7<9/;868:1-%9?3;39396:1(:768=<12=46566/@>>=<:?B573;=>?593<>C;>;>-?>9;<7-7=@>;@?;@AB5;<>7;@8:9?35?=>:A;?:>>@CA7???8@7139'16>:65,47?B><<89A:?<;>C:<83;88&3635?;81<37>;->@>;><1<8?3:@>=>BB7>8A:?A.63?;C>3<2@=6B?<7910<94;=?A26A3B?8=;99.568;;<<166B@?>?3<@<;=>@C?496?@>?>5&732@/?8?@@:?-;$:68CA6;?=9;>:;6?->?>;@7A??07@C:?>::=8295:=97<;(;16:7:A5<=:<=:79:6(55)+:+8>7AA?=>9=7:79::1=>4*42;8==2@8:;&8;:C@4AA<96?@B<;%;,7)?A=A:::F@D@@?>;2;<;877)806;BA@DA=/6#/:98=>4D@3>A4>???9?7:8?BC8B9>D>DD>@;A5G:09C;AA:=DAE?E@=>9@@=DF93CA@9?0D?A889?>EG>CD>>B<6?>D<8:83@A8;=DFB?CD<4?C=AADAB>6E:F=:D=6=E@C@;>7;<;@C=GDA:?>E?>DCBA;@BDF?A:DD=D>97245FB=?8A5*.87*A@?4==C2>+=:<:/EF<7C9B=DDECBB&;98@DBEEC4BGGD5C)@B@45B=>9==%>>.:13D)98CG@AA@=?B?:>@'><@B?1267>5:C?A?@>0?C7;?6C<9$?=867+6=>><@7=(:5;=C>:4>8,B@A;>>A<73%ABB@.7BCDCG??+?=7B9@93?D@=.@A=C8::EA<9;DB0:=95C81EEA7AAAA@9DGF?'C;=A(%:2?C<>A<<8>*BC5DB6A:77D?C;*C>FFAA@7@<)9AB@DB>773=3A;B@B>DFCDE9G='=+>@E6B>B2AB>@3ECAG:BEA9FDDE5BE+=C=3A>A77>A7<99;9%=?.=>A9+9B6B;AB8BA426:9=?DB@BC-B@:B@CACB9AC=?7@*D=/@DEBEE9D@?=2C3=AAA294BEBA;;B@:;A=E;?7@:>=3:<*?/AA?9AA1CB4=+E2;8,@6:?B=CB7>;BC1)@=9=@AA:B8AFFFF:F<:AB>A>BE:>)??5;B-@;@FCEAA@@?E:4;?ECACEAGA-B?A?BAEA@@AE?AFEFD@+CB7:B>EFB*DE8B @rCer/788/1931_61_CCS ATGGGGGTGCTCCCAGCTCCAGCGAAAAGCCGCCGGTGTTTCTCCACCTGGCTCTCCTCTATCTCCGGGCAGGCTCACCCGAGATCCCCCCACACCGAACCCCCTCTGCACGCTCGGCCCAGCGCTGTTGCCCCGGGAGCGGACGTTTCTGTAGCTATTTGAGCACACCTTGACGTCGGCGGAGGGAGCTGGACAGGGCCAGCAGCGAAGGAGGCAGGCCCCGCGCGGGGAATCTCGGAAGCCCTGCGGTGCATCATGAAGTTCCAGTACAAGGAGGACCATCCCTTTGAGTATCGGAAAAAGGAAGGAGAAAAGATCCGGAAGAAATATCCGGACAGGGTCCCCGTGATTGTAGAGAAGGCTCCAAAAGCCAGGGTGCCTGATCTGGACAAGAGGAAGTACCTAGTGCCCTCTGACCTTACCGTTGGCCAGTTCTACTTCTTAATCCGGAAGAGAATCCACCTGAGACCTGAGGACGCCTTATTCTTCTTTGTCAACAACACTATCCCTCCCACCAGTGCTACCATGGGCCAACTGTATGAGGACAATCATGAGGAAGACTATTTTCTGTATGTGGCCTACAGTGATGAGAGTGTCTATGGAAATGAGTGGTTGGAAGCCCAGCAGATGGGAGCACCTGGACTTGGGGTAGGGGAGGGGTGTGCGTGCGACTTGGGGAAAGAGGGTGACTCCCACCGCGAGGAGACAGAAGGTGAAGACATCTAGAAACATTACACCGCACACACCGTCATCATATTTTCACATGCTCAATTGATATTTTTTGCTGCTTCCTCGGCCCAGGGAGAAAGCATGTCAGGACAGAGCTGTTGGATTGGCTTTGGTAGAGGGATACGGATGATGTAATTTCACAGCATTCCTGAGATTTAATTTTTGTGCAGTTTCATAGAAGGGTCAGGAGGTGGACAAGTTGGGGCCAGAGATGATGGTAGTCCAGCAGCAACTCCCTGTGCTCCCTTCTCTTTGGGCAGCGATTCTATTTTTGACATTTGCACAGGACAGGTAGGGAAAGGGGACTTGTGGTAGTGGACCATACCTGGGGACCAAAAGAGACCCACTGTAATTGATGCATTGTGGCCCCTGTTCTTTCCTGTCTCACACTTCTTTTCTCCCATCCCAGCTGCAGTCTCACTCAAACATCACAGTACCACCCCAGGGGTGGCAGTAGACCACAACCCAGAAATTTAGACAGCGATCTCTTACCTTTGGAAAATAGGGGTTAGACATAAAGGTGGTTATGATTAAGAAGATTGTTTTGTTATTAAATAGCATTAAACTGGAATTGACAAGACTATTGAGCATCTCTGTCTAACCTGTTCTTTCTCTCTGGTGCCCCTTATCTCACCCCTACCTTGGAATTTAAGTCTCAGGCATTTCCAGTTGTAGACTAAAACCACTCTTAGCATCTCCTCTAGTATTTTCCATGTATCAGGACAGAGATGTCTTATGTAGGGAGGGAGCAAGTGTGAAGTAAGGTAATTATATACACCTCTCATTCAGGATTCTTGCTCCCATGCTGCTGTCCCTTCAGGCTCACACGCACAGGAATGCTATGTGATGGCCAGCTGCTTCCCTCCTTGGTTATCATCCACTGCAGCTGCTAGTTAGAAAGGTTTGGAGGGATGACTTTTAGTAAATCATGGGGATTTTATTGATTTATTTTCACTTTTGGGGTTTTGTGGGGTGGGAGTGGGAGCAGGAATTGCACTCAGACATGACATTTCAATTCATCTCTGCTAATGAAAAGGGTCCTTCCTCTTGGGGGAAATCTTTGTGTCAGTTCTGTCAGCTGCAAGTTCTTGTATAATGAAGTCAATGCCATCAGGCCAAGGAAATAAAATAATTGCTTACC + KIKJJI5HIIIKK,HKKKJG=JKIKKKHIKJKK,J=JHKK4KKKJ?KKJKDIJJJICKJKJKJKKBKK6JJKJJJHKKKBKKJHDKHIKK$;KKD>JKDKKKK=IIIE?B:CKJIK@FJCJA?GIIKK.JKKK3KK:IIKKCJKJKKJKGKGKKJJJKKKAKCGKKHKKK@CFIFJJKJJKK=KIJJEKKJKIKKKKGHKK=JDKJJIHKKKJGKDKHFKKHKKKKKKKKIKGKKJKIKKAKKKKKFFKHKKKKJKKKJKJIKFKKKJ/KKJKEKKKKKKKKKKKKJKJKCJJCFKJJJIJJCHIH-HKFKKJ/JJKKKHKIKKJJKJJKKDKKCKKKKJJHHKKKK@KKKKJIKKGKJJKKKKHKCKKKKIJKKKKKKHDK>JKKGKFH?=KHDIKIHBGHJKKKJJKKKKKAJDJ8KKJDKKKK@KIFDJKKKK-JFFHKKIK@JKK>KK>JKKJJGHKJAKJJJKEGK>>KIKKKKKJKEKKKKAKKKKK?IIFHJJJJFKKKKKJJKKJIJGKJKJKKKJKCAJKK4KKKKKHKKIHIJHKIKFKKJJJKKKHK;JJKKKKK+IIIKJIKK8JKKKGKHKK?JKKEKJKHJJHKIJJKKIKIJIE5HHJKKKKKJJKGKKIIKIDHJ0KKHI@KKKKKKKKKJKKKK&KKKHKJKHKIKJDK5KIKKHIKJIJKK;KEBKKEJEEJKKKKKK1KIHGJKKFJIKEEIJIJKKHKIKKKKKEKAFKKKKJKKJKKKKKKFKKKK=K>DKJIGKJDKKK:JGFKJJKEKKKJHKKJKCKK?KFKCE@GKKKIGJKKKKFKKKIGJ0CK=JFKKK1JJKIGJKIHEIK+KHKKJJK?KKKHCJKKIKKEK/GJKHKKFKGJIKAIFCKJKKJKHKK@KKKKKKIKIIKKFKKJKHEHJJHHKKJBKKKJKKKKIJJJJEKIHKKAKJJJJKKKGKKIHJ6KKIJKKKDKKKKCJKHKKKKKHKKKJKKKKKK'JKK;KKK=GKKKK.KKKKKK=KCK>KKKHJJKJHIKCKJKKDJKKKIKKKKKKKKJK7KKKKKKDKKKKKKKHKKKKIKHKKKKKKIGKFKKJKKKK7KKFKK&KGJKEHGKK#JKKKKKIKKK'JKJKHKKKFKKFJK.K0J6JC=F"KKE8K=$=GKKJKKKFKKKKKKKDKK:KKKKK3JKKKHKFBKKJKKKK:KJKKHKGKKKKKKKKKK(KKKKKKKDKKKKKKKK@KKJJAKK=KKKKKKKKKK>KKKKKKKGFKKKKKKKKEKKKDKKKKKKKKKKKKKKJHIFGEB<.GFEF:?E=?H<:,BAF,H8KD1F.DJ=6HJI@IEE1E;EGFJDD9=F:GJ0>HFGA+@IDKDG@AGKJIDBG8GEGJEHCGFJJK@EJA@?=:I9EFH@F3@FDKKCH@4I>,-B=$A?DECCE@DFB;+>IIJIDEIHE1DD5BBBEBB)HF?EA=B7E@AJBGE=CG?96EDCEJDK>F?CC>/FHBEEH+GAEIDGEB5=EFDBB*2=0CFGDFHBE1?;FAA;6H7H7E4DIBG2@DABGHDABIH/IH5CEJHHFD9FC>DI?C@?F??&C28.7?=EEHAIIJDBJE-3A+BHFID?=5HK0FG@BIE1C>BC+CJ@IC>CFB<0CBFICEHBKAEGIIGDAFCFI9IG=:=FCCKK@JH0?FG?B?GHFJFEG@6?KIJDI2FJAF@@)FJ@IHFF=?==HIG?D(ACEE@E;IBHHFEJ>=<8EB?C?DFGHHGHH+AHHEH9JFCC:>?E=*?ICEBF7GB8;@FJDDDDEGE'JAIG;HF=9@D97AEH;GE@FJ>ID>=??GD(BEFHEH8CB@:>@DEABFDHIHGCDAA-HCGHHIC.8D?G<7>887>FJJ9H>J@8FA*BDGGADKH@I8KEJIGCFGFC?IJ@HCDH6JCEAGCAF8J?J>G3EJGFIKGFEAIFFGKHCJKCJEDHIJI@ICIF/HBGGIKKK?IDHHKGI5GFEDDK?CGGKB@CFH=IHGKJJE?FJFGIFGIEHHHI>@@AJIJHK6FE.FF;EIGF:AK@I?IFDDHF4H:EHHGEDCJKDIFJGIJEFI9AEI6@IJKJKFB>/A0;>76FBGIEAI0KJJB=K3HH=HEDIIKKH?FB8CEBHIGKG8IEABAGKGJEJ7IJ?0HIKHJGGIJIEFIH:CIJ7CE>DDKGCA?>;BF8F?F?IK9>>GABGJJKEIIC>IGK$ECG;HHEJ?GD@BEEFI3DJCHKJ9GGIJI3?BIGEAAG/IGAFJII>EDB?KG:IHJKIH3DFFC?GFJ@CG=C9DIKBIDHKBJ.93HIIKFJJJJH<=KKKFFK;7DIK8JEJ?GGHFFGIBDIJI*ECADDIJ#JHKIB>>>BHKHIHEI?EK?KGEJIKK>K<>H=FEFGG;HBHIEAE;B=A8>?FGIFIC8:E=EADF/FECCE(=7DIGDDF8HG:??A'/:.H6D?CE>BC8CBDEFFD>CC49>8IH5ECEE:5FFC$>DGHEDB(>FFHI@H>@?GIHDF@FCCA@DAE>@6I>?A<6CAG)4;B6FA:HGI931B-B?DECCF;E8==E5DFD=(<2ECAB$6D;E?;9@DDC34DH?I6E:AEA56=DCC%6>5?F3B;FG:GBDEH0GDBC@@?'B:76EH.8F0?6>9=D4:@B>2D.AGC(;B@-A08>%9EE19+;:=F7=BADG@@%:CA9DF:?ADA89:>;;4EF??>=@G5G?:@BDE3B=AF;$=<6>>@,DGEF7?E=-BGG>D;D@F7?ADABABD,@=;2<8:?C:GCIB?7C>98>A<;:7:;8=B=5?DF0E7@>*>5@?CBDB>7+JJ9>D68?9FAE@BF2GI83BD.G?:IIFDE/GHJE0GEF6DEHEEI=CF?DFEFGEFFBCBEF(BC?=FAG6=<9>CEA4@I><FF1?AGII:GIJEC>CAE@1BI=?IGIE@/@55@.>GFHH@9D>F2DIIEFGFAEGGD'ACHG*DCB7BIG>F;BBEEDFE;9@>;<'CEH@CBDD?@B>GIJJ6@@7>?E?A&@88EAEAA>D9CE@:;4?DA9II@G=?D87E2D-CC>>;GCF>HIBHEJG?FBF9F=CF?ED>FG2H87BBEHE>DGBEHID<=HCACFH>H:@6BIEC3EC'IH@)3FI@DB><%D2;;EGF7AJIHGGG@FG6DHAA;?H=DB-GCEHDF/FC>?BB9DC>:?EF@E<=?7?EHD7>HIHCDEG3?H?@B=?GIFH@J?F@DCBEHAD6<=8AE@AE7GHGEHHF@JE7=C3CGFF5DAF@JFC;@8CH?EAFFF;I=8IFBGDJEG<.ADE?C?@>A@GDBJCCAG=AEF>FIFEC*?IB>FE?;CFA>HB;8>8A@@?EGB;?DEI2;?GGF>>AC=A=;;?7:BDD2EF@GEAC:C;;4=;?B>E?D?C2<>AC<=BC>:B=3B?>1:3,<9B7ACB;74994>@;)>,9B?,?C@:;;<8>6B@=>;:1AA?4A?BBA,<91A@12>'<85><@1($<@@A?>27?<;9*=?A?2B>=;42>>@BB,8:A275<45:55:485C:=?>'A?;;>4=4;+5-3=AC68:BB36A?>4>;315+@.><8?>@4@;=0=-951><7:>9C-;@@<)6>>>=?>B=7>+86691A=*(;><-<>@9BBB?;8;B/8<8>/:?AC@?B/@46=46@;=82=ABB>@>>9B>/@;070?>=689>1<>5=A=*96>9B<7;8@7-=8>>3>;7:=)=56;8=3;>;3<997:9865'07:>66$+<,5=;88<<4=9=3;:469;,;0<85$16<:+:7/237'5?=>0;//6 @rCer/794/25_1610_CCS ATGGGGCAGTATGCGTGGTTGGGGAATTCATGTGGAGGTCAGAGTGGAAGCAGGTGTGAGAGGGTCCAGCAGAAGAAAACATGGCTGCCAAAGTGTTTGAGTCCATTGGCAAGTTTGGCCTGGCCTTAGCTGTTGCAGGAGGCGTGGTGAACTCTGCCTTATATAATGTGGATGCTGGGCACAGAGCTGTCATCTTTGACCGGTTCCGTGGAGTACAGGACATTGTGGTAGGGGAAGGGACTCACTTTCTCATCCCATGGGTACAGAAACCAATTATCTTTGACTGCCGTTCTCGACCACGTAATGTGCCGGTCATCACTGGTAGCAAAGATTTACAGAATGTCAACATCACACTGCGCATCCTCTTCCGGCCCGTCGCTAGCCAGCTTCCTCGCATCTTCACCAGCATCGGAGAGGACTATGATGAGCGTGTGCTGCCGTCCATCACGACCGAGATCCTCAAGTCAGTGGTGGCTCGCTTTGATGCTGGAGAACTAATCACCCAGAGAGAGCTGGTCTCCAGGCAGGTGAGCGACGATCTTACAGAGCGAGCAGCCACCTTTGGGCTCAACCTGGATGACGTGTCCTTGACACATCTGACCTTCGGGAAGGAGTTCACAGAAGCGGTGGAAGCCAAACAGGTGGCTCAGCAGGAAGCAGAGAGGGCCAGATTTGTGGTGGAAAAGGCTGAGCAGCAAAAAAAAGGCAGCCATCATCTCTGCTGAGGGTGACTCCAAGGCGGCTGAGCTGATTGCCAACTCACTGGCCACTGCAGGGGATGGCCTGATCGAGCTGCGCAAGCTGGAAGCCGCGGAGGACATCGCATACCAGCTCTCACGTTCTCGGAACATCACCTACCTGCCAGCGGGGCAGTCTGTGCTCCTCCAGCTGCCCCAGTGAGGGCCCACCCTGCCTGCACCTCCGCGGTCTGACTGGGCCACAGCCCCGATGATTCTTAACACCGCCTTCCTTCTACCCCCACCCCAGAAATCACTGTGAAATTTCATGATTGGCTTAAAGTGAAGGAAATAAAGGTAAAATCACTTCAGATCTCTAATTAGTCTATCAAATGAAACTTTCATTCTTCTCACATCCATCTACTTTTTTATCCACCTCCCTACCAAAAATTGCCAAGTGCCTATGCAAACCAGCTTTAGGTCCCAATTCGGGGCCTGCTGGAGCTCCGGCCTGGGCACCAGCATTTGGCAGCACACAGGCGGGGCAGTGTGTGATGGACTGGGGAGCACAGGTGTCTGATTGTTGCCCCCCAGGGTCCTAAAAACTTGGATGGACTTGGATAGTGAGAGAGGAGGCCTGGACCGAGATGTGAGTCCTGTCGAAGACTTCCTCTCTACCCCCCACCTTGGTCCCTCTCAAATGCCCAGTGGAATTCCAGCTTGAAGGATTGCATCCTGCTGGGGCTGAACATGCCTGCCAAAGATGTGTCCGACCTACGTTCCTGGCTCCCTCGTTCAGAGACTGCCCTTCTCAGGGGTTCTATTCCTGTGCTGGGAAGGAAGCAACCATGGGAAGGAAACAAATGTGTATAAACTGCTGTCAATAAATGACACCCAGACCTTCCGGC + >D'E>>CFDDE@E79F>K-F2GAA4/7@4>0=79IB?EBHJJHD<>@>FBI;0H65BKKHBD??7B?@K=GC@4?6IGH>FF?F=5?>F>3D=1>47A7<;7F8G?DBGF;G=9@<;;<<5CA>JDBG3GC?D??1KJ?GFHGHEIGFHC3G@8>ICEDK9@@H@HIC@KCD?JFG5H=FD7GGB;F6EJJDGFCEJ7IHE@IB87BJHIEJKIHGH@KF@GHE:EEDHH4FHGAADGBECEGF;A<:GA3@?9IBH0BFEBICFCAHEKJIK8BCKBHKI;544AHHGJ>FABJC=IG?HBJJH@FGIGHCEHGIDHCCE/?@C@CHIAGEEJG<7GIGHH>?CEIAKHB@DIHCJD;FID;BF0FF:DEBHE0E@A@@>JIJJDIDHHJKHIIJCAAD9@FBHFCKEKGHKJJ?D3DKEGKIGFCKJHJKKF=HBKBKKJKHIH4BJHGEEEBJ2E=E@J>ED9D?FJ>,IGIFGDGBF>BGDG;5F@8DF>FGBCD4<@F>FD:EDH=H:GHIK>HJ;BIJJ@:HIJK;K@JGCJIHKDEJKAIGK)BJ@AKDK?D@JI9KE,FHG>JK@5KKJJDKAKHEKECKJHKKK9FKKJHKEH=IE4KKJGKK?JCIAKJBGKIJKJGCF93EIIJH?GKBIJI7C:GKKID@J@1JJGE=JKC8D=@F=J?;IKKKF;KIKJI1HDEGKEK?JJKDGJDF;JB:HFA@ABD2FFFE5K9@JKKGBKJK0FKJ8JJB>1*EKKKKKJ9KI8IJDK?IG?J=CBGDGHHFJ?HHBF9JHJ9EGIH=CHCKIJJ:HGE?HF=JH>G.AEHJDG@@E=@HF3ABG>>C5BHH?1JC?F8FKFIEKJI=DA/AG@@=BI@BCD9EEDKK=KBJHKBFD0A=EFC@*IIG=@FG=DHF7GG@KFCHDHHJIGCBGA9G-FFCE;:CHKEE;HEHG?FBJJFKH%JHFII@FCH=B?BEBHGDKI;HHFDG=E:BFJGJ>AHEGKJJ>CF?4C5>DCGFGCJHIHJBE@D$FGGFFG>I:D9JIEJKGDI?+E<=I:DIF@B?I2AAIGIIGHEKK@KKJK@IA@<<>HABIDBJKI>GJ/CFJBGBKHICK;JJH4A3>97@JII>CG@CDJICK@AID>DBDGFC@>>EFJDFFDDB?3G@=>GJIFBD=GEBCC@IHHJDGC0GCAI@JJJIDAIFAEC=HCFFH2?6 @rCer/795/2674_62_CCS ATGGGGACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGACAGAGGCGGCGACGGCGGCGCCCCTCCTCATCATGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACGGTGGCCACGCTGCAAGAGTGCAAGACGCTCTTTATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGCCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCCGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCTTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGATATCAGAATTCTTGTGCTAGATGACACCAACCACGAGCGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGTCCAAGAAGAGCTCCGAGATCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATTTGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAAAGAGACCCCCAGGCGTGCTGCACTGCACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCGGAGGATTATGCTCAACAAGATGTGGTAAAGAAATCTTACTCCAAGGCCTTCACACTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTGAGTGAGCAGCAGCTGCAGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCATATCACCCGTGGCTGCGCAGCTGACGTAGAGGCCGTGCAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGGTGGGCGAGCTAAGCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGGATGCTGAACCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACTACGGAAAAGGCAAACCCGTGTCCACGCAAGGCAGCCGGAAGGGGGGCGCCTTGCCGTCCTGCACCATCATATGAGTGTTCTCACCACCACGTATGCCCCTAGAAGGGAAGGGGAGGAGAGGGAAACGTGCCCTCTGCTTGATCCTTGTTTTGTGATTTTTTTTTTTTTTTTTTTTTTTTACTCAAAGTTAACTTACCTATAGCTTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAATGCTCACACTCCCAACACAAGGTGGGCGGGGAGGCACCATTCAGGAACCTGGACCAAAGCTAACGAGGCTGGACCAAGCCAGGAATGGGGCCACAGCCAGAACCCCGAGCCCTGCTTCCAGGTTCTAGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGCGAGTGGGGAGACACCTCAGAACCCCGCAAAACCCACTGACCAGAGGCAAAAGGCAATGGGGCTGAGGGTAGTTTTCCATGGTCACAGAGAACTAGTGGTGGCTTTGAGAAAGGGAGGACCTCTGGGCTTTAATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTGTCTCCCAAGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAAACTCCTGGGCTTAAGCCATCCTCCTGAGTGATCCCATTTCTTAATCAGCATAGCCCCAAGAAGGCTGGGGCTATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCTCCCCTGCACACCATAACTAGGTAACAGTTTGATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCACCACATCCCCGCTGGCTGGGGGCCTCACTCCAGGAAGGGGCTGGACTGGCCGTCCTTTCCAGTGGCGTGACTCCGCTGTGTAGATGGGGAGATCGAGGCCAGAGGCAGCACCCTGGTGAGGAAGCTCCAGTCCTGCTGTCTACCCAGCCCATTTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACGGGGGCTGGTGGGCACCAAGAGCCAATGGAGTAGACCCCTGGCTGGTAAGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTGGTCTATGTGCTGTGGTTCCTGGGGTGCCCTCCACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCAGGTTGTCACTCAACAAAAAGTACTTTGGATTTAAGTTACTATCCTGGCTTTGCCCAACCTCAGCAACTTGTAAGACTGATAATGAAATAAATCATGTTAAT + <8AF@-CI5GJFJGHFIJKAIJIJKKJH@IKFBEKBJDC3G2JFKIJ?J=+@J=IIJEJ@?@7KDJE>JKGHH?FCJKH4@ECIHI5HFIKKBKIJKG7HE;DFIK;HIEIK@KKJDJKJ=FBGDIBKHEKDKKJIEJIIJKKKE@KCIH?CJJKEJ@EKGIFIHBGIKJAFKGKEF?KGACIFDCKGGKJFKFHJKHJHJ?HKIJJI:FCG1II5KK=JD<6JI@DF6FBJJ<<6I:8@DEDDFD=B=IH?E=DJJIGID2=A>?@FDGC8CE3BE7?HAD?;EAHDGGEJICG@D??D;G=?)AB?;84@@CEGC@C:EDCHHBFHDKFFGC=7B;GHBJDJDBD/EEBK?DCGFIIGBGHHHKHIIII;GJKC3AIJBCKK=DH?;24GCA;EGBHBGCH?JIADHFJJKB?GDF>2D@B9EFEG8BCBBFFC@IHI?J?JIDJI:GAJCGIFG8F@JIG=FHKJ2IIFFFF5@8BIGAHIF>EDE=JKJAICHJFH2:3DBD=8AFIKJIJC@HC<6IGGACAI?CA9D8>A-)?>6?6HFEE2B6EC;15I?>IIFFJHCKIIEGDEHEIJCAJJEII:FBEDDAHFGA@E;F>2KHCKDIBDBJEEIA=HHE:EIHHIHI6E;@9?CF?5GDE:FICF97@@;BCBAJBFG@GFFFIG?8=>GJ41;FEHJGBKHBAAB=FBGHAB;A6EJE=IHE?FIK;FG?9GFE>96A3A(G@>AF3GHI@D8@CDBKAFBKGI2:<36CFBB=>;@??HH1G?G?IIAGI6+GAFGDED=EIIDH@C;9HA3EJC?E=IEC7CECC69I,E?HIB'EGAD7HE6DID>GEEFBH>ICDHCHGEHH@$CA.1.+>BADCA;>=>@:?AA<>>A>@#9=8GE=KKK>DH?=95/@3IGDC2EDADG*FBE89DE8CFAF=@@74@<9>;5@B3?4CFAC6G@BC=&6JDB3D7>HJIGEF8C?;5I:DA@B>G;;DI/FIIEFF?CHG@C>8FDB8.CKAEFEHHEICIIJBA=III>D?EDHHDD@FEC9=JJ?@GF<&7=@2;8@F7GCF8DAB<@;DE;GJF>D>FHE:HKHIJE@IA>7;5GF8DDIFGAGGCCDFG<>B@:6F@9>>JKH7I?DGHGC>;K?EA:D@A@GK@FFG4AA;FG1C@FGIH2@GD3E=K=ICIEBGICIIJ@GEGIID+;EG%=HE>CI=>A6EHC0>/FB8A3:B,J4DI>B?BA267CD>@3D@A=C7JFEGF39<85>=,CEC:@B?07/74>B8@G??FGC.8?<9:@89A@>C2C@FAE)ECGDD;9D?FFC,'?A&=CDGA;JGCGHHK6HDDHBH?IIIDC?DHB97IACHFB;<@@AAICH=CJ:KGHGEGIKDGDEECHF=8AGB9BGIKEJGIAG>HG7JIFGGDDCA;9B?F7DCDI;@F8E>D;9DGA8:FFIGIIGJ=IGIE+IJ=HJBG9ICIIF>;JJICDHAE?GAAGIA9DGCG7FEA@;9KAGJGGFI;GHKJIGID@?&HDJJJK-IHEKK9HB@==FJG>?=4DHGB7>2@B:1D/:7CFGIDJ:FJEJCHIGGK>:CFIHGGKI;BIH;HF@FIJ=KKG @rCer/796/25_1936_CCS ATGGGGGGAGCTGCAGCTGTCTGGACGCGCGGCCGGGCTGGGGGCTGGGAGCGCGGCGCGCAAGATCTCCCCGCGCGAGATCGGCCCCTGCCACCGGGCGAGGCCTGCGCCGCGATGGCAGAGATGGGCAGTAAAGGGGTGACGGCGGGAAAGATCGCCAGCAAATGTGCAGAAGAAGCTCACCCGCGCGCAGGAGAAGGTTCTCCAGAAGCTAGGAAAAGGCAGATGAGACCAAGGATGGGGCAGTTTGAGCAGTGCGTCCAGAATTTCAACAAGCAGCTGACCGAGGGCACCCGGCTGCAGAAGGATCTCCGGACCTACCTGGCCTCTGTCAAAGCCATGCACGAGGCTTCCAAGAAGCTGAATGAGTGTCTGCAGGAAGTGTATGAGCCTGACTGGCCTGGTAGGGATGAGGCAAACAAGATCGCAGAGAACAACGACCTGCTGTGGATGGATTACCACCAGAAGCTGGTGGACCAGGCGCTGCTGACCATGGACACGTACCTGGGCCAGTTCCCTGACATCAAGTCACGCATCGCCAAACGGGGGCGCAAGCTGGTGGACTACGACAGTGCCCGGCACCACTACGAGTCCCTTCAAACTGCCAAAAAGAAGGATGAAGCCAAAATCGCCAAGGCCGAGGAGGAGCTCATCAAAGCCCAGAGGTGGTTTGAGGAGATGAATGTGGATCTGCAGGAGGAGCTGCCCTCCCTGTGGAACAGCCGCGTAGGTTTCTACGTCAACACGTTCCAGAGCATCGCGGGCCTAGAGGAAAACTTCCACAAGGAGATGAGCAAGCTCAACCAGAACCTCAACGACGTGCTGGTCAGCCTGGAGAAGCAGCACGGGAGCAACACCTTCACGGTCAAGGCCCAGCCCAGTGACAACGCGCCTGCAAAAGGGAACAAGAGCCCTTCACCTCCAGATGGCTCCCCTGCCGCCACCCCGAGATCAGAGTCAACCACGAGCCAGAGCCAGCCGGCGGGGCCACGCCCGGAGCCACCCTCCCAAGTCCCCATCTCAGCCAGCAGAGGCCTCGGAGGTGGCGGGTGGGACCCAACCTGCGGCTGGAGCCCAGGAGCCAGGGGAGACGCGCGGCAAGTGAAGCAGCCTCCAGCTCTCTTCCCTGCTGTCGTGGTGGAGACCTTCCAGCAACTGTGAATGGCACCGTGGAGGGCGGCAGTGGGGCCGGGCGCCTGGACCTGCCCCCGGGTTTCATGTTCAAGGTACAGGCCCAGCACGACTACACGGCCACCGACACAGACGAGCTGCAGCTCAAGGCTGGCGACGTGGTGCTGGTGATCCCCTTCCAAAACCCTGAGGAGCAGGATGAAGGCTGGCTCATGGGCGTGAAGGAGAGCGACTGGAACCAGCACAAGGAGCTGGAAGAAGTGCCGCGGGGTTCTTCCCCGAGAACTTCACCGAGAGGGTCCCGTGACGGCGGGGCCCAGGCAGCCTCTGGGCGTGTGAAGGAACACCTCCTCTCCGAAAAATGTGTGGTTCTTTTTTTCTGTTTTGTTTTTGTTTTTAATCTTTTGAAGAGCAAAAGGGCAATCAAGAGGAGACCCCCAGGCAGAGGGGGCGTTCTCCCAAAGATTAGGGTCGTTTTCCAAAGAGCCGCGTCCCGGCAAGTCCGGCGAATTCACCAGTGTTCCTGAAGCTGCTGTGTCCCCTAGTTTCAGTTCCTGGCGCCCCTGCCCGTGCCCGCATGTGTGCCTGGCCGCAGGGCGGGGCTGGGGGCTGCCGAGCCACCATGCTTGCCTGAAGCTTTTGGCCGTGCCACCCGGGCAAGGGTCCTCTTTTCCTGGCAGCTGCTGTGGGTGGGGCCCAGACACCAGCGTAGCCTGGCCCTGCCCCGCAGATGGTCTGTGTGCTGTTTGAAAATAAATCTTAAGTGTTCAAAACAAAATG + /0$*(*,+11,/1,-1.+&.0/12*))+)*%##$$-0*+*/1--),,/-441..-/,*)./2033(1.*40011./-1..-5.1-540-1/2.*-)&+.20'2.3233113453.40501311-/)540104/56/23655.4.34164.420115246530&,*1*1,/00.4503./1*020)2/250.-/2.'(106,441,.3..5403+-4%231061143422.0(.).(211&11,+35'4445/-0444344466426.42&/30064556.,.,*/55-4433(/*)4/1/+45.216243526.1,()/,(,(*2353524/.455456.3-/0+$+*-.'.--)0/*.2.4406010300361.-4/44564)1331,0/4,.223-656155.206233/0-12)660.415+./1,22415.,010//1.442351*,*00,-2'%.'%(&''),-1*2525,02/,0215333-.1./20-4650.526553.64125203//5,434131.53353404251103*253-1.123300/.426525640.*41151-/&)+./4+1/.)-.022/((&,+''&&.14+,..#-,).*/11.55,400,3*23-*-1/1+.-,(5/+-,3-52*0153/.+3.0-/1++$&0)#$&+5423514465/445425-11.11446516211044454-12-4/.1304400414500/3.565644044465,20-336401230,3.4/40+31443/1,4455555353*3.-2/,15*3535,255462601*30551.6322.0(-.(/30/.4562.431'23.3---0&,&(*,/..-.,.+.240645/4-41123+0260)*/+0311.53,*1+31604/2303215,551661.4.463*442+.04+*%///.216226)$*%//3330443+540/5.1.01445641,1/34310.44*3.)#%$"$)''$%(%',3452/&,..2/1120211.)0/1.2,+-,0+&,'-01(,-..1-*1-+,0)+)-)+*(,*0&.*-*++*,,)$-,,)0'*&+*$--.-+),&&*+&*,+1.+-'((1-0*1/,.-1,-/0.'-$++++*)%).+**),+,.+/)((('+))'&,,,,.,'--/.1.**)),.,+())&(%&*)$-.,'+,/+$/0.)*/))+/('0.&)+.1/22-0/-021*,$%.101,,&/*)*(,+*)++*+*)(*(%%*)*+,+'%%&%'%'**,0---+.+-&'&/0,1,-0-+)'0+)&*+)(&(&&,*'*&+)-1.12011-/,0),*1+,1.,0/1,012111,'-221101/2,1/-/-,-'0/,/*000-0.-100-211.1--&&1'*)%)')(*')$$$*-01),/-+-,'+++*0+*//.-0'*01-.*+++,,+.0'1-((*+-*,/01+10-,/22*0//&'/0&%)+).12*,0*)$')+%./.--/0/+)-&.)'//-0/0/1,(0/1112-22/*2/'--,.1.1--1'/)-*($&&(+--1-1,+(--*-*&(0/221+**/+--/'/-)%&),+*+)(+')+))$'&$%"%(&%))-'*('%&+*##$"#&'-+)%002,,,1/,/$*/**.0)0/0-./--2,012,,/000101/-/**.10%(*1.*(0)10121*)/-/-,%,+*/*(0.++((*/,/102,*002-01.021)0.0,0+0.)/.),,1/1''*+++'000(,+,,--*&'*"(&&$&%-()))//*10++..(202.10210)////2/(10111./,/,+',*.(,0-,01111//&+,)/0--1-0/12-+&(-$***-11111.1/,0011..-&,&+-/12100).++/(,#%*/1,-+(0,-/&/-101 @rCer/799/269_58_CCS AATACACAGGAGGATATTTCATTTCTCTTAATGAAGCTCTGGCCCTAAACCCTCAGCAACTGTCTCCGGATAGGAACATGTACAAAAGCAGTTAATTAGGCAGCTGGAGAAAACCAGAGATCCAGTACAGAAAGGAAAGGATATTTATTGATTAACAGAAGTTGTCTTTTTAAAAGTGTTTATTTTTGGCAATAAAGAGCACAACATAATC + /$+*,0,(*)11(%/0661102'*2/(,150221,#&$)(%)33-4/,'%&$10+/*,%.(.-&,73:1340/&1'/+3.4...26'6:62,.0'8.47,261&2/193379#688=;4;532?5<3458?7/4814)95190>F7=:18'CA<381126BA6C1D29HF0C6BE069A+=BD8@?=255BA&29 @rCer/800/27_2850_CCS ATGGGAGTGGGGCCAGCTGGGAACAGTGGGCCAGGCTGGAGACGCAGCCTGCCGGCACTAGCTTCATCTGCCGGTTGGTCGCGGCCCGAAGCTCCCTGAGCGCCTTTTCGGATGACCGTGCAACAGCGGGACTGCGAGCCCGAAGCTCTCGCAGCGAGGCACCACGTAGAAAGAGGGACGAGCTCTGCTCCCAGAACCCCAGGGACCCCTGGACGCCTACCGGCAAGGCATCTTCACTGGAAGGATGCTGCGCTGTCACGAAGGGAGGACATGCTCCGCTTAAGAAAACAATCTTTCACTCTCGAGAACGACCCTCTTTCGCCCCGTCCCTGGGCCGATCTGTCTTTGGAACAAGTATCTGAGCTGAACTTCCTTCGATGCAAGCGATCTTCGAGTATGACTTCCCAGTCGAATACAAGTTCAAGAGCCCTCTGAAGGTCCCCGCCTGATTCAGTGCCTGGGGATGTATGACTCTTCTCTGGCTGCCAAGTACCTCCTCCATACCTTGGTTTTGGATCAGCAGTTACAGTTCTGGTTCTGAAGACATCTCACCTATATTCAAAGATCTTCAGTATGGAAATTTTTGGATGTTTTGCTCTGACTGAGCTAAGCCACGGCAGTAATACCAAGGCCATTCGTACGACTGCCCACTACGATCCTGCCACTAAGAATTCATCATACATTCCCCTGATTTCGAAGCTGCCAAATTTTGGGTTGGCAACATGGGCAAGACAGCCACTCACGCATGTGTTTGCTAAGTGCACGTGCCGGGGACAGTGCCATGGGCTGCATCCCTTATCGTGCAGATCCGGACCGAAGACCCTTCTTCCCATGCCCGAGTGATGGTCGGCGACATGGGGAAGAAACTCGGGCAGAACGGTCTGGATAACGGTTTCGCCATGTCCACAAGGTCAGAGTTCCTCGCCAGAGCCTCCTGAACCGGATGGGAGACGTCACCCCCGAGGGCACCTACGTCAGCCCCTTTAAGGACGTCAGGCAGCGCTTCGGAGTGTCCCTGGGGGCCGTCTCTGGCCGGTCTCCATCCTGAGCCTGGCCGTCGTTAACTAAAGCGGCCATAGCCATCGCTCTTCGCTTCTCAGCCACTCGGCGTCAGTTTGGACCCACCCAGGAGGAGGAATAGCCGTGCTTGAGTACCAATGCAGCAATGCCGCTTGCTTCCGTATCTGCAGCTGCCTACGCCTTAGACCACTTCTCAAGTCGCTCTCCTGGACCTGGTGGAGCTCCAGCGAGGACGTGCCTCGGGAGACCGCAGCGCCAGACAGGCAGAGCTTGGACGTGAGATCCACGCTCTGGCATCAGCCGGCAAGCCCCTGGCCTCGTGGACGCCCAGCAAAGAATTCAGGAATGCCGGGAGGCGTGTGGAGGACACGGCTATCTAGCCATGAACCGGTTGGGTGTCCTTAAGATGACAACGATCCAACTGCACATACGAAGGTGACAAACACGTCCTGCTGCAGCAGACAAGCAACTATTTGCTGGCCTCCTGGTACACCGGGTCCGGGATGGAGCTTGCTTCCGCAGTCCGCTGAAGTCGGTGGACTTTCTGGACGCCTATCCCAGCATCCTGACCAGAAGTTTGAGTCTCCAGTGTTGCCGACTGCTTGGACTCCGCAGTCGCCCTGGCAGCATACAAGTGGCGGTTTGCTACCTGCTCCGAGAGACTTATCAAAAATTAAACCAAGAGAAAAGATCAGGAAGCAGTGACTTTGAAGCAAGGAATAACTGCCAGGTGTCCACGGCCGTCCTTGCGCTGGCCTTCCTGGAGCTCACCGTGGTGCAGAGGTTCCACGAGCACGTGCACCAGCCCTGCGTGCCGCCCTCGCTGCGGGCCGTGCTGGGCGGCTCAGTGCTCTGTACGCCCTTTGTCCTGAGCCACCACGCGGCCCTGCTACCGAGGTGGATACTTCTCTGGTGAGCAGGCAGGAGAAGTATTGGAGAGCGCCGTCCTGGCCCTGTGTTCCAGCTGAAAGACGACGCGTTGCCCTGGTAGACGTGACGCTCTCCTGACTTTGTTCTGGACTCACCGATTGGCAGGCGGACGGCGAGCTCTACAAAAACCTCTGGGGCGCTGTCCTGCAGGAAAGCAAGGTGTGGAGCGGGCGTCCTGGTGGCCAGAGTTTCTGTGAACAAACCTGTCATAGGAAGTCTGAAATCAAAGCTGTAGTGCGCTGGCACACATTCAGCCAAGTCTAATGAAACGAAGGAACTAATCAGACGTGGACCTCAACTCTGATTCCAGAACACGCTGGAGATTGCTGCTGCCTTCTGAGCCCGCACCTCTGCGTTAAACTGCTGATTGACCTCACCGCCCAAGGCGGACGGGAGGAGCGCCCGGCCGGCTGGGCTGCTCGGGATGGGTGATTTGCAGTGTGGAAAAGAAGCACGTGATCATGTCTGCGACGCGCTTGGGTTTTTTGATCATAGAATTTCGCACATTCAGGTTTCAGGGTTCAGCTCCTGACCTAAAGAGACAGCCATAGTCAGGGTTTTCTGGTCAGACAACATGTTGATTTGTCTAGATTTTTTCCAGAGCTCCACTTCATGAAGAAGTCAGTGGTGCCAGTCTGGTTCTTTGTCAGCTTCCCTCGGCCTTGTCACCTGATCAAATTATGTCATACCTATTAATTTGCACATAGATCATCTGAATGTCATGGTTAAGACTTAAGAGGGACATCTATTTGATTACTTTCTTTTGTGGAGCTGGAAATGTCTGTCGAGGAAATGTTTTTGAAAAGTAATGATTTGAGTGGGCATTCAGTCTCCACCCCCGCCCCCTGCCAGTTATATACAATCGCTTATTCG + "$"%%$$"#%%%%%#"#$"%$#"#$$$#%$$%%$%%%%%%$"$#%$"#%$%$""$$$"$%$#%%$$%$"#$$"$"#$$%%%%$%$%%$"""#"""%$%%$$#$%#"%%$#"#""#%%%$%%#$"%%$"%$$%$"#%$%%%%$$$#$$$$$$"#""##"%$$$$%#"#$%"$"#$$%"%$$"%%%%$%$$#%%%%$%"%%%$"$$#$%%$$$%%%$$$#$#"#%$%%$"%%$"#%$$"$%%#%$%#""!""#%%$$"$%$""$#%$#$%$$$$""$%%%$"$#%%$%%%#"#%%$$"%$"%%$%%%%$%$%$#%$$##%%$$"##!"""%%$$#"$%$"$%%%$#""#%%"#$$%%%%$$"%$%$%%%%$"$$%%%%%%%%%%$#$"$%%%%%$"$%%$$%%$%$$"$""#%$%!"#""#%''())((&))(())((#$#')))%((%&(()'$$((%)$$%%&(%$%'(&(%$$%($$((()(%(%(&)$%'()%'("()'%'%('&()%))(#%&'(%(%('#(&))(%('($'%)($&#(#&%'$%(#'()&,-(#''$,-+,---*----,%'*,..))*--+-)*)+-..-,&*,,--(-----*(&),)'',**+)(,'+,-(,+-)-,&*'*'+*,*,--+..-+,(,--*-.,'(-(,,)'$&)*.*,---)(,)*+&*+*(+('-----.,(,---%,,+..-)-+,,+.--.)-+&,,+,.+*+(&+---,)),,,%#%&)()---,*,'"&',-**-(+).,-'#',*-+-%()--,,*---,.,$**--+($,-,)))&$,(+.,&,+,$*().+&,,..(''&,(#(&&)--*(--+-*+$((,),,))))'('+--,..-),(*-+.--')-,)+*---&)(%,)---+%,.--,.-.,---)()-)&*-+)-,$,-,.,)-,,+.,-*,$)',*'%++)*)*%**+++-,,.,+(,'),)(+((+-,-',+')%,()),,)'),*--+()-,)-,),-,,.-'$,,,,'&$+$&)(%,''%*)&)%),+,.*+-,(-'(,)-'&%&&+*+#)+.--*$-,-&)*,,-)+-----),--,+--,*,+(-,-,)(*-*,,(*$,*(+*$,+*)-+)+.-,.)('%,#&((,*('&)+'((#$$-,.----+-)-,-(-),&+*+-.-.-)(((*#(&*,+)(+,-*-')',,-($('()+*($('(+--+$&$+-*-.-,.-)--')%&),+.-----),)(',)(--,$*++,--.--,'+)(*,(()-,,&,)+--,.)+(),)-*,(*)-,-,))+,%++),,%+)-(*(,.,'---''*%)%'&$',*#*)-))''"""$*,''(++.)+&#%*(-,(%'++$))'+*('$#(),--,-'(*))$*,++#+(-,-%)&-,),)'-,.*$'(('',-.-+-*)+(()(-,,),'%'('*%+,-)+'$+#&*+,(+&(-+*,*()+,*-(+%&%,)+,'**&*"#)&+))-+)---,-,.),+((,*---,$'(,-%+,&$-+.--),*$,*)(,(,,,))+((+'(+--',(--+,+.+---..-(*(,,,#'((,--,-,*,--+#),((,,+*+&,,&,,')()*).,.-,))--,(+(++,..+*.)**-+*,--.---.*$,(**'&+--.---*%+,')-,,+)-,-,#++*),.,..*-(-+'$#,,,%%%&,,,#)),+$)(+,)--,--*,%+)+)**',--,)-,$)(('(-+&#')-)*$,$&$+++,**'(()'++,-&(,,--+.-,$+'),),-+,#**--,('))*))*--,,.(((+++--,&)+.,'+-#+,)(+-,,.-.-,-,((,*+).,,*%&')-,-----,*(-,*.*$$$(&',)*----,(*,',*-'+%#''*-,-*-%$,&,--,,,&+((*%*-,,-(-'(+-,,,-+$),-),,-),*,(-,)+.)+.+,.-*)*,+$,**,--+-.--,+---+#',-,*,-,-%+(-,---*#-*'#'()(*,)(,,+,-((+-(&(*-,.,'',,*,,&#,+.--,.--,++(&,-,$+++*+.-,,)--*-,(*,-*-++(+*-&,%$+).(+&)#',+)'$*,,-+,.,+-)*-,.((*+#**$%',,'.+(-,())+*---(',,.,)+#)(,-,---*---*'--+)*)-+)*-,-,+--.-((+*--,,(--.--&**+-%"%.+.,%%,))+'*&&(&)*)-(*$+%(,,),+.),*&&+%((&'(',',-),--),---',(-,+-(,,,.)(('+,(*-,(#((,,+('$%+'&)(,*-)*((**+..&%)-)*--,(+,+#)&')('++*,-.,-,(%,,)+,((*"*+%#$&**,)*..,*'*,)''+#(((&&&$(&'&+,'('(+-+,)+--+'+),)%#&(,*--))-),*,,%#$,-%+,(,*+(,)+-,')%,,*(&&)(,--&&)&),-*+'-,,*)#$)+,(),'('#'+,$)%#+,,,)')+,,((*)+(%$)#&%&%+('(+,,-)$()**)(*,---)((--,)+(),('-,*.--+-)'(-,()(,,)+++-+.-(-*(+-)&%##(),+-&,%"$-(+,(,*-+*))&++)---*-(*+%+,#')(,-),,*---------+))'(((+')(+-,%$#+*---+)+&&$*)+-,,$$*,)'---+(+,-(-*&),--))+----+,-&,,,-------,)+.)-))+$),+,+&++**)%&,,'',+(*(,,.-(#(--*-,'(++#$**++*$,+,+'($&&,),*&%)&(#)+--*#+(&*,- @rCer/803/25_2390_CCS ATGGGGACAGAGAGCCGAGCTCTGGAGCCTCAGCGAGCGGAGGAGGAGGCGCAGCGGCCGACGGCCGAGTACTGCGGTGAGAGCCAGCGGGCCAGCGCCAGCCTCAAAAGCCGCCAGAAGTACAGGAGGAACCGGCGGCGGCGTGTGCGTGTGGCCCGTGTGCGGGCGGCGGCGCGGGAGCAGCGCGGAGCGGCAGCCGGCTGGGGCGGGTGGCATCATGGACGAGAAGGTGTTCACCAAGGAGCTGGACCAGTGGATCGAGCAGCTGAACGAGTGCAAGCAGCTGTCCGAGTCCCAGGTCAAGAGCCTCTGCGAGAAGGCTAAAGAAATCCTGACAAAAGAATCCAACGTGCAAGAAGGTTCGATGTCCAGTCACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTACTTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTACCGTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAGTGTTTAAGAAAATATGGAAATGCAAATGTATGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACATGGTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACTTGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGAATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCAGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGTCAAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGAAATGTAGTAACAATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTGCAGTTTGACCCAGCACCTCGTAGAGGCGAGCCCCATGTTACTCGTCGCACCCCAGACTACTTCCTGTAATGAAATTTTAAACTTGTACAGTATTGCCATGAACCATATATCGACCTAATGGAAATGGGAAGAGCAACAGTAACTCCAAAGTGTCAGAAAATAGTTAACATTCAAAAAACTTGTTTTCACATGGACCAAAAGATGTGCCATATAAAATACAAAGCCTCTTGTCATCAACAGCCGTGACCACTTTAGAATGAACCAGTTCATTGCATGCTGAAGCGACATTGTTGGTCAAGAAACCAGTTTCTGGCATAGCGCTATTTGTAGTTACTTTTGCTTTCTCTGAGAGACTGCAGATAATAAGATGTAAACATTAACACCTCGTGAATACAATTTAACTTCCATTTAGCTATAGCTTTACTCAGCATGACTGTAGATAAGGATAGCAGCAAACAATCATTGGAGCTTAATGAACATTTTTAAAAATAAGTACCAAGGCCTCCCTTCTACTTGTGAGTTTTGAAATCGTTCTTTTTATTTTCAGGGATACCGTTTAATTTAATTATATGATTTGTCTGCACTCAGTTTATTCCTACTCAAATCTCAGCCCCATGTTGTTCTTTGTTATTGTCAGAACCTGGTGAGTTGTTTTGAACAGAACTGTTTTTTCTCCCTTCCTGTAAGATGATGTGACTGCACAAGAGCACTGCAGTGTTTTCATAATAAACTTGTGAACTAAGAACTGAGAAGGTCAAATTTTAATTGTATCAATGGGCAAGACTGGTGCTGTTTATAAAAAAGTTAAATCAATTGAGTAAATTTTAGAATTTGTAGACTTGTAGATAAAATAAAAATCAAGGGCACTACATAACCTCTGGTAACTCCTTGACATTCTTCAGATTAACTTCAGGATTTATTTGTATTTCACATATTACAGTTTGTCACATTGTTGGTGTGCACTTTGTGGGTTCTTCCTGCATATTAACTTGTTTGTAAGAAAGGAAATCTGTGCTGCTTCAGTAAGACTTAATTGTAAAACCATATAACTTGAGATTTAAGTCTTTGGGTTTTGTTTTAATAAAACAGCATGTTTTCAGGTAGAGCTTAACAAACTAAATGATGTGTTTACTTAGTGCAGTTTCTGGTTATGAATATTATATTGCTATGTATATTATATGGACTCTTTAAAATGATTGACAGATTGGCAAATTCTTAAATCTTTGTACATTGTTGAGTCATATGTTCTTAGAGTTAAATTTGTCTCCGATAAGAAAGTGTTAAAG + 8-/9988::257::8;898::974;53/:5::::8559082/934542978992:7;7;625.5,41+39759852421.3*+5:85316939*6-99942+852/5998*67579:/956465797121:1:8;::;846489497::583,42794284801853/971:35:,54.55863238;15:7;:808;86:6*6457*532.;81::86:9:78:5446836(6472949480885698169:::;:85.4438157312149:858+72:7:8:6--34225.684378:7;2/.(76:::71.88;49840997&7842899::,:88929-6929:9968358%01999::4-7563977:97542.6855::9/5779:7748:55;/85673349:::6:6:*848769:2857252635870695729:/765625875;3757:6997/07:7:9394428;8:458-8:93148767-85081,4527:19153..364:73(486:476;894898-3./:29827::949:99:1785876884:65:85.488876968-5136:62775094/92(46:*8789505697:6786;55962;;:6765:-:92)7)89::89..04;:63-656138955.*0755489:4).-*#*&&%.)550.9797;78;:7(96496-8735489791'7316;:79:788365.78:8:9-4799:7335564::6-3::689:57347819::.835:2990:7,4,5877.6-5;:5-1/337:5878:-98:::6776366587456,4/88:636:70:-5*862/75-12/28:828::986.260839.19497-:79'15,8:7706:7198885;;49::57987-73.75:196::299;7715277665762043963*07.7:6754;96716)-1,8;:95660233:8%455915::4;92:.5976:65870$8*479439;2/88::67:923:8898;.5055687;4866555977:42570598:09098899:7:9;99-93::3%878829::::79;6439:6::;:687,::84672955420,4:84,375168516:8;:9:99&3352:7'57/.9778:433976914:28;5::6;37377446995387)5)5:29:9,997;9993-37::88;:68;0:78::57::+:935.52999:9695,598884479.7994/8808:027.7076845329;:761'856.685:8519:66;8219:8:;756079::8259:39979:;:9.82:8:3974,87:4845087;89-37:7;8+78764296-78767547876-68:7(3:796-*6786533859+75-/69797893857:878::485/6977779::557856:7;4:5/,7.55/1-9385762::/876;8;53:81567:8644(86,39:8:5254.799:9:3537-6./3.5/7948949::9:636:557076;:9:99:-::9*$777677;9::68,9799;:59:09,7976;77343*8870,44375+10+67993+69999'88975/683;;57(77397;::53513:9::24887+38.9/95567$206:::6::61,0.7.9:66::8;81997;8:8;:0:9::::599;54626:559949;;88;735.93/3'755678:86:486:7:2087746.8798::945836459::7:9685::8%876659164235205457388186:3;06945:;25979;:-86822.598:6:5;4(854/:9599&2)2868)703$(/376689:1895819494339798)36518/9-5621399/.987539/*69512:965/83;46:161798(9'9.18954880:74'63654095980:9(167:/99:;:::;8-93,487572+22865954'2//7-4::765-14373197:685//1849;858;:+7759879546;378>=89;39??>>2>=6:<;=6<;/;<<17>6::5<<:=57<97<063<6578-;;:6:>>786=>9;>=>>/=97><9=<>93<=1??>9-=>8.6518;<:9;;798$589<=:?9=:;3<091;;6??<68?9>718>=8&;9:>3?:=;>=>97?>627?5=;9<8=876:38+*776:>;8=7662=6<:889=<868<>'68869<>?>99=;<:?>=<7==;?5:<:=?<>:=8>5??9?;:=6446=>:47=/><;=>2>0?:4 @rCer/804/25_2573_CCS ATGGGGTCTCTCTAGTCACTCCGGCGCAGCGTTTGTGCCTGGTAGTCATCAGAAAGCAAAGCCCACGTTCTTCTCTAATACGTGTAAGCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTCAGGCAGAAATTGCCCAACTCATGTCCCTCATCATCAAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGATTCGCTATGAGAGCTTAACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGGATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCAAGTCTGGTACTAAAGCATTTATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGACAGTTTGGTGTTGGCTTTTATTCTGCCTACCTGGTGGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCCTTCTGCTGGAGGTTCCTTCACTGTGCGGGCTGACCATGGTGAGCCCATTGGCAGAGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACTTGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCACTCTCAGTTCATAGGCTATCCATCACCCTTTATTTGGAGAAGGAGCGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAGCCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGTGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAGCTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTATAAGAGCCTCACCAATGACTGGGAAGACCACTTGGCAGTCAAGCACTTTTCTGTAGAAGGTCAGTTTGGAATTCAGGGCATTGCTATTCATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAAAAAGAACAACATCAAACTCTATGTCCGTCGTGTGTTCATCATGGACAGCTGTGATGAGTTAATACCAGAGTATCTCAATTTTATTCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATATTGAAAGTCATTCGTAAAAACATTGTTAAGAAGTGTCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTGGAATCCACGAGGACTCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCACACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAGTTTGATGGGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGAGAACCTTTGCAAGCTCATGAAAGAATCTTAGATAAGAAGGTTGAGAAGGTGACAATTTCCAATAGGCTTGTGTCTTCACCCTGCTTGCATTGTGACCAGCACCTATGGCTGGACAGCCAATATGGAGCGGATCATGAAAGCCCAGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCTGACCACCCCATTGTGGAGACTCTGCGGCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTCTCTTCAGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTACCGCATGATCAAGCTAGGTCTAGGTATTGATGAAGATGAAGTGGCAGCAGAAGAACCCAGTGCTGCAGTTCCTGATGAGATTCCCCTCTTGAGGGCGATGAGGATGCGTCTCGCATGGAAGAAGTCGATTAGAAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCGTGGCTCCCACTGCAGCCTCAAGTGCCCCTGTCCCACCTGGCTCCCCCTGCTGATGTCTAGTGTTGTTTTTCCTCTCCTGTCCTTGTGTTGAAGGCAGGAAACCAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTGACAGCAGGATTGGATGTTGTGTGTTGTGGTTTATTTTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCGTTTTTAT 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@rCer/805/2181_60_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGAGCTTTTGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCGTGATAGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + 6@G@(>CCJEDEKAJ+HF23HFIJHFHFGH=HKDCFHF9IHFD;EJKCIJJICEH6DJBJDHHAEKDJB9GJ/JCJBJFGFKIDBD@JJH)JJHEGHKKGIKI.KJ@GA%@@DF>F7KIHGG&CJHDIHBIGG7IKJKKIG>')?I;CK.JEIFG;GAJJIKKK3F'7HCJKEIJ1GJJGJIIDF?@GA=F=>C.HFG:EGEFFIFGJ(AG@EJ>9;%?:EJHEK?EG*AFI0FC<*DBC@)4F@=?C%CBDC>B5B2>=?FHEIHCIEE'J@@/@D=G5?@HBF@II6ACCBB(77HHBF@IECB'=DH=C8GFC>;AC'FFBE@DDG/E?DDBFDGB@CI=HGGA)>GF?A7B8GGE@%CHIIGIDIIA>/>BJAHC?CDCD(G@6DIHFJFI,DIJC?BDID.F?A;ICEFEIDE>=4@AH'GFHIIHGFG:>EE=C'H;EEGHHIFCGFF-BIIFI8IFFIHHFGAHFFIII>;1CH@?'AG*IGBDA>E+94EEI@?@2FEB*H8EEB?@+IICEFFGGGFBEAE&IIHHF6DAE7G?IIJ,EJFEFI:HFDIFDD7B=GJHE0H?EH3ABE>=IBGIGIGHFCJ8IFD8%>B?FFEBFBB5BGJ4A=JJ8GF?BBDC>HCIEF=BGJFHEEHDC*IBE;HGEBF9@FHJIE)FB9=DBD'=FC?-FHI3GFIH@3C;DC=;D(FAH?>HCHGF:EBEEGG?GI?EH2;>FE1?G:IJJ6H>ED+DHB3D7A%HJGDJ<@FAHAEI>FDD='IJ=H:I6II9HBAA?C@EFGEBJF=DHCCFI9BF1HI9CEFIIH>J8FDD48IJAGJBH@IHIJE/J?JGCI2IG?GI*GHFHJCH9GFF0FIHBJGIBIFCJHGEDIFEGFFDIF::@F@FH:IHIDD:GH55-BJH;=?==2==BFHGG0EB?H;HFFBCIE?IH@';H:FG@HA>F=IDBFJ,HHG@EDHFE9BC-G+C@DEA@I;=B)7AB&AEDFI?@JD>ECDIH>@FF>@HGGC>89%=@G@&GDCEBCD>FDI@>C)FF@.>C'@DB6FG=?DDH@JBFBE7GIIDABC>GAE;BF6DI4:BJDHFGFGD6F@C6&,F>*CBAB,94;&?JE=IJCID@CGBIIFG6CA0HHG8>HIEA@ECGEC=@$>1HC@B,BBA>;)DF7>;???@&E:B?DE,9@%>CC??B@?97;&>:>AAAA>?BDAEE@FC;CBE99???@FGFCE8GB>A'9CDCFGFG;FECC:CEDE39CBA:FG8==8C9E?B=:E?AC:BC@GAE<=C?=A@(A?EF;BAB7ADB@;%B>CBAB)FA27DDE&CFEEFC?0A=?B@BGBEAECB>AD4EFB?BB=C@FCB@D;;BG>E??7A?1ABG<@;B<@>C0E2@C:C-1BACABEDC?CE?>DC@=GC=??C>@D1EG783>;7F?FE?C4B@DDGE?C?FGDFGG;FEFF @rCer/807/25_2000_CCS ATGGGGCTCCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTAGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTACTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + 63'97((6-37745:+388>=+$1458+74:*;95;895125869137:22741:9641883:<445$4/0*.2,4*35*77676;2383<,99<75:9/+:><87::59:74;5;:9:2;99:-*/58;=8;:<11439;7*06:71173<76:241,9<<;>9==$3186,3587=63,19565=<94/85:473956978686739-=94/=943759=>693:9-7:=84632:;,7%470;=69>:8*;8577;:74+59:7:<6,1893<54*965:2863?5?<<72/0468;?5:8=:;3570749<86;;:6=5:7;:859715.:1;84;<49479:899::36?887594:-394:55:2;:77<77=9>8:;0;-4:23513;65(21/9/=43::26;057159:3849:6929:18639<0:1<99<61:68:>=-%098=>9:6955709:8:292898;==6:;23804164+141.42;69;5<.<>369112;9<<=96<'*-%)4,/12644/934:98:<24984-;:5/287369757:8689:857:-7=799-8:%9:7(..77/9523:081678)9348;:21:5(628484254-42)3489;92;6156;%8447528<52285478579:5,164;933.7-16,69;;26:>8>943:'-4:5;2:7:;:/7>;;:9.5<<698597;979/:-335<<01+3-17972::;::79::37:58;6445;72.836;.-9<:<9877824$433#$++45<<28348=0)19:87291+76;;99735=27;-5/+228.7593(062%2/)65<5726)07,67;5/6/615/72272;472:+416863->;<7<5:/850::76666=::7=2?8*9;<=8<;86:786:/::*8529656875689:=:<,3;<88;;69;89;47<0=8=9978:657;:84;73148$816;7=4:.8:$'99<;577<6/86094<0547/;8.;:5+41751$39658<165;035371*:9;64(.77-686)7/337/-64766;=:>884835456958839;<97::&/625:9;8;8674,2999:98:9<896746:2912812765:786;05?12<:9<9241*9:;5:2:34&=649;.:==:6<%840%+8<0<<1>=;9:/86=;53>62:9:3>4><::67;769/24434746/,+3)/6:;58674701.6/<3:864',9:075:44884;377=5:;=+'897.3640:8;75979(829::61947524:+4196<;:3784;6887:93$//669.59><6=9:>7:15283*751<4977:0<:876/>79;?@&=98.6+704A;<;BBE7>??2@D=A<>;F&C=B7C?(BB?/@B8;?BD=945:;;;8AA>A<>A?F>?<3;=9CBB?;668>AC@A=::@::C7EA9A,?>>7BD?;BC8D2B><>0>>>;8<%3?;C5./?:>@:;=F?E>?D5GCA0:<;?=:@?C?@@EA<6F9>7:,8:7<>C:9(=<9=AB@DB9>C>9*;BBBFA4@=D6>>=0??:A>8:=5167C//CE>:B>==;?79=640?<80>=>?:=:;48>?4;><;?789-9;>?>=:<>;=3;2;8?7>9;;1=2>>:69;=<+;16?::9;=9;=<867>;7?;;9>8769;>>:=3/5=413498>>98257104-863.363;<>><<<6>;<2=:7>9>:2;64+5139=96:<==:05==?;5975<=<<6=>226968>=?7;>;;?:=79>249>3<8>=<8;74=?749%=::58$9<><87:=7;4291?>0=9==0;9395<6=9?8;><<2;>974?8>;898<47567=99>;399>769;;>?6;:15:>9;=813;3=7:3=253:1;>:3;;6656*94;;:4<+4597::&966=7747:2821374246755784387087353851/802-4%6389674725;:8<39:;;<=;9<:8:=019==;4>=8>7><;8>79<:98=85<6;2:283=;3;<;896<>789::388;9>>35=::910241558/862<3<1=4;0:92,7:;7>919;7;;>=9999=9>?9=<<:>??<83;:>;9?88;;;<799;;;09=<;27895;+=9:;=9<>4>;;:=;6966438:;84,9;898=16856??:<3>8;=;9);177=<5;>>7;;865903<;.?=9=<7:6?>?;9=<49:?66>6;.:;7><>?5788<9%:;=8618>;79<<3:=8<<<'7?9=79>:7+<06=;?827=<:624;:;>;<=4569:8;6;;;(9<<>/:.;:%4>;?<;?:989;6>;;342:?9?;9?:=??;;3943%;9>>?;:3>=;<9.327:2>;<=427%864::=871:0;8;>8:75)=>>=4??;?848;5<2;8?>9=67=58;?7>;;7<83,9;4=35>=>?2>>9:<>>:8;0599(62==6;:>;;>/5909==055427645&298/95<9=;41=5;;396202<*?8::789;669138;5==5<=;=7>7425779=;8<;7,3;.<:30<;7.797924/,,9.928;75;5::7-23;69.:8;876;;?6<>=8;8;-?;:9-92<<>777<:6;8828.;;708=*6<+;>:9<;853:9'12<8:97>95;=62.):;:;;;>9==1<>79:;<<6;=??:<8<75:>81779,31469438:943:+1954).56::::38<<':::95858<<<4;95:18=/=71;9.:3:;897:<;768788709>;:=;<;7<2;39=.197,7740689/96:5115::0/659967:;674'6&:8963872'5839:8:4*,61;:8::83.0166/0.#259928-5/::689313:99194659:4:9058;667$1.358#/22:98::01,:56/9:20,8:4646,9835:87441/4:3.9947;7:57:84.46096761'89715/4,*%8955:;68/9396:73-900.5,7/24125053155645143&+3355.14*4641-556.0534+,20311(0,656//3/6604555+1,3.-36540/45(4.3,.%234--,$355+3-405646/.446./.1,**02344+5642,2662.13%415156663246631513031/-,#/+01.0,$-2.0-/525(0/4-4.-1,(/3/),&42)23+//,3151-00-/1505))/231602),402.5/24234-.2/*544535-232-.52212*11/01033)554666656620661/.4111..56142.) @rCer/811/25_1780_CCS ATGGGGAGTCTCTCCACGATTCTCTCTCCCAGACTTTTTTCCCCGGTCTTAAGAGATCCTGTGTCCAGAAGGGGCCCTAGCTGCTCCAGCCCGCGATGAGGAAAAGTCCAGGTCTGTCTGACTATCTTTGGGCCTGGATCCTCCTTCTCAGCACGTTGACTGGAAGAAGCTATGGACAGCCATCGTTACAAGATGAACTTAAAGACAATACCACTGTCTTCACCAGGATTTTGGACAGACTCCTAGACGGTTATGACAATCGCCTGAGACCAGGATTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTTGGACCGTTTCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAAAGGTTAAAATTTAAAGGGCCCATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAAATCTGGACTCCGGACACGTTTTTTCACAATGGAAAGAAGTCAGTGGCCCACAACATGACCATGCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTGACAGTGAGAGCTGAATGTCCAATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGCCCACTAAAATTTGGAAGCTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGAGAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGATCTTCTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATGACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCATGCATAATGACAGTGATTCTTTCACAAGTGTCCTTCTGGCTCAACAGAGAGTCTGTACCAGCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACGCTAAGCATCAGTGCCAGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCAGTGTGCTATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACCAAGAGAGGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCTCTTATTAAGAAAAACAACACTTATGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCCAGGGGTGACCCAGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCCAAAGAGGTCAAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGACCGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCTACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAGATCTTTTACTCACATTCTGTTGTTCAGTCCTCTGCACTGGGAATTTATTTATGTTCTCAACGCAGTAATTCCCATCTGCTTTATTGCCTCTGTCTTAAAGAATTTGAAAGTTTCCTTATTTTCATAATTCATTTAAGAACAAGAGACCCTGTCTGGCAGTCTGGAGCAAAGCAGACTATGCAGCTTGGAGACAGGATTCTGACAGAGCAAGTGAAAGAGCAAAGTCATGTCAGAAGGAGACAGAATGAGAGAGAAAAGAGGGGCAAGACGGTTCCAAGATACAAGAAAAAG + EF(IHHHGICB@I>C7AED=F7/B@AD3>BF@HF5GJJF-#@BDAEHHBH8E7DH>6;FGIF@FHHED9I%=@F>FGBBBD@8ACDIGC=@FHDIDHHC-E2DCAGI:IICIHEFFHGIE>EGAA@1IH1DJ;F@9HGC9G=BHBIE>@HGHIFF=GEB=?BJ9I87CCA7EICECC>CBHGFAIGBGG7B:=BDFFB@E4FDHA=AGGG;EAF7>@EDC?C?B<:@@6GGGDHFHDGHHGCCIEHEC6C:EFDHE9G/EE<<@BGHHFAFJ?B>@HE>F>B=@@BEDIF'D47FD@HHHCA9=9>B?DHHDA@8>/41@FEC=@63DECDBE6D)@@25B>D85BA5DB@FBD0HDF6>AEII@EEB?BFHIC:AD?0FEIEGFB><39.8AF@DBEGF?DDGIG@4BCDADACFHE@9DBFCHB>4C7DECFBA?A>D3@=;@=>C5AB9>?8CD9D:;A3B@32:1@=?A0C@EAGB>D=?DA8EC=@DB??@=???5@2>4B?=7>@FEFACCD=?A<@>;2;6B?>3B>5@=F<>6BC5=D??:B>@B;;?F8AB7;,==999ACD@CDCD=GE<=F7<=0C=9=B3AA?@BGFBB;?DABA9DDCC@BF9<;A@?9D8?5>9???EBGD@FA>A>@B>EC4@CA:E@GCAGDDD??9CB4E;AE>@=@EC?7EB@B>C?6A9@756B>=EDBFD?E;@?D7A/A>E4FDBB)B<:8GE7CE::A3BDFGD;BB=F:>>DEFEDD=AEBC>5@B>D>B@B=>EF=CE?DB=D;;=4A@@>>3E=?@;@1D@:72/52B7>><>=3@B?21;C3EED?3@D@==>CGBBCDCCD7ECGGD:CDDE:GE@FD=1D@AAFFBDC,>2@:?D<8?24@CAAEB9A>AE9AGDCE?4=@=/BC6BAD;DACGC2@;D86B=:CAAB:F=@=;@AC?4C=3;AD=A=D3A@CG@2@DC;C9?C8@FEEG>4@CA:@CF>DC9F;=EBD?DEBE5;B>?BFC=;7DE&<@89A>DC<;DBB>CAE3CED?7CABCD?D:@B@DB@1??A?<=:FEBD9A=7>C=:B2>A?BE=CAD4CB??474<4@@@>?AGF>D,C@B>9E>>D.>7FCA4::EE.DBB@AC493=DECE?GAEEE;D3CCD7EEE:GD,?AG@:D>@2?3:D9E?<>ADDE?6=A=G?@>?#?;9<=4;:?;7@A6DBCDA>DABF>FFF;DC5D:;@CB9A;E@?7@@EB@?BE?8BEEE<7DF>?A<9:7?B86@)87C=E+D9?AC=6E83FBA;> @rCer/813/1553_51_CCS TTGGGGGCTGCCTGGTGTGCAAAGAAGTCCTTCCAAGTCTCCAGGACTGGACTCTTCCTGAGCAAGTCCGGTGTATAGAGAAGGAAGCACCCTCACCATGTGGCTCTACCTGGTGGCCTTTGTGGGCCTGTACTACCTTCTGCGCTGGTACCGGGAGAGGCAGGTGGTGAGCCACCTCCAAGACAAGTATGTCTTTATCACGGGCTGTGACTCGGGCTTTGGGAACCTGCTGGCCAGACAGCTGGATGCACGAGGCCTGAGAGTGCTGGCTGCGTGTCTGACGGAGAAGGGGGCCGAGGAGCTGAGGGGCCAGACATCTGATAGGCTGGAGACGGTGACCCTTGATGTTACCAAGATGGAGAGCATCGCTGCAGCTACTCAGTGGGTGAAGGAGCATGTTGGGGACAGAGGACTCTGGGGACTGGTGAACAATGCAGGCGTTACTAAACCAGTGATCTTATGTGAGTGGCTGAACATGGAGGACTCTATGAATATCCTCAAAGTGAACCTCATTGGTGTGATCCAGGTGACCTTGAGCATGCTTCCCTTGGTGAGGAGAGCACGGGGAAGGATTGTCAATGTCTCCAGCATTCTGGGAAGAGTTGCTTTTTTTTGCAGGAGTCTACTGTATCTCCAAGTATGGAGTGGAAGCCTTTTCAGATATTCTGAGGCGTGAGCTTCAACATTTTGGGGTGAAAATCAGCATAGTTGAACCTGGCTACTTCAGAACGGGAATGACAAACCTGACACGGTCCTTAGAGGAAATGAAGCAAAGTTGGAAAGAAGCCCCCAAGCATATTAAGGAGACCTATGGACAGCAGTATTTTGATGCCTTTTACAATATCATCAAGGAAGGGCTGTTGGGTTGTAGCACAAACCTGAACCTGGTCACTGACTGCATGGAACATGCTCTGACATCAGTGTATCCACGAACTCGATATTCAGCTGGCTGGGATGCTAAATTTTTCTTCATCCCTGTATCTTATTTACCTACATCACTTGCAGACTACATTTTGACTAGATCTTGGCCCAAACCAGCCCAGGCAGTCTAAAGAAAACTGGGTTGGTGCTTCTTGGAATGAAGACAAAAATCTGAAATTAATTGTTAGTGTCTCAGTAATCCTGATTTAGAACCCAGGCTTTTTGTAAGAATGCATTTTCTTGCCTAAATTCATTTATCTGTCATCATCAGAGTACTAACATGTTTATATTTCAGATATCCAAAGCTTACCACTTTAGGTGATGAATCTTTACTATTTCACCCCTTTTTTGATGAGACTATTTTTCCAGAGTGAATCATTTGTTCTTGCCTTATTAAACACAGTAGATGGAAAACAATTTAACCTATTTTGAAGTCATTTCTTTACGAATATGAATAATTGTTCTATGCTTTAATAATCTATTGTGAAGAAACTACTAAGAAATATGTTAATGTGTTCATCCTTACTTGAAATGGGTCTGTATTATGGTACTTTTAATAAATATTTGATTTTTCTTTCTCT + KKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKIKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKIKFKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK5KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKK=KKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKIKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKJKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCKKKK @rCer/818/687_64_CCS CCTGATGAAACAACACACACACACATAAAACAACAGCAACAACACAGAAACAACAAAAGCATGCTCAGTATTGAGACACTGTCAAGATTAAGTTATACCAGCAAAAGTGCAGTAGTGTCACTTTTTTCCTGTCAATATATAGAGACTTCTAAATCATAATCATCCTTTTTTAAAAAAAGAATTTTAAAAAAGATGGATTGACACACTCACCATTTAATCATTTCCAGCAAAATATATGTTTGGCTGAAATTATGTTAAATGGATGTAATATAGGTTTGTTTGCTGCTTTTGATGGCTACGTTTTGGAGAGAAGCAATCTTGCTGTGAAACAGTGTGGATGTAAATTTTATAAGGCTGACTCTTACTAACCACCATTTCCCCTGTGGTTTGTTATCAGTACAATTCTTTGTTGCTTAATCTAGAGCTATGGCACACCAAATTGCTGAGATGTTTAGTAGCTGATAAAGAAACCTTTTAAAAAATAATAATAAATGAATGAAATAAAACTGTGAGATAAATATCATTATAGCATGTAATATTAAATTCCTCCTGTCTCATCTGTCAGTTTGTGAAGTGATTGACATTTTGTAGCTAGTTTAAAAATTATTAAAAATTATAGACTC + 2'(100(+/)*.302443///32/+-))0'.5-),++1-00--&01/#&$.-,*'%*%*,$$,0,(++,(($00,00(,,/00,(&(,(.',(*(+(''*/+(**$)&(+-/.*,'((1/+--,0/$.'+,-1,+*+--0++1/*+/&/1/2,1+//1,-1/'1)/,(*($+0,-+0$--'-22/11111)-//.0*0+*))+$*+/,,2/-,-)/+*.10-*0'0/-.+.,0.%')*+,)*)+,000(,$()+2,1,**),)--0/+*+-'.-..../.,)('(),-+&-.1.+/'-))-+/&,**)+$.(10-&*(,&,0..&/,1-.11-10,1,-.*11).,()-,.)0-,1100,/1,0+''($'+$*1.1-0+0,0,,/)/0++.)0----+01,(+&',-'--))(,%&$(%&&&$),('%%$)%$*-*-.+))+)&-)(*-*,,&+(),-,(%&(*+'%++'-+.*-,--,-*'(,+&%$'&+$,+,+((,+'$#$+)-*,--(')*)(&)+--+*%$$#+'(,,)-%-,*-..+*%,+%,)+,&))*+-(,*-**'*-''('(#&()'*&,+,,..*,,)&,--,)*-&&,-0%++1+#(&*)"++0--++)+- @rCer/819/25_1686_CCS ATGGGGCTCTCAGAACCTTCCTGCCGCCGCGTTCGCACCTCGCTGCTCCAGCGTCTGGGGCGCGTTCCAACCTTCCAGCCTGCGACCTGCAGAGAAAAAAAATTACTTATTTTCTTGCCCATACATACCTTGAGGCGAGCAAAAAAAATTAATTTTAACCATGAGGGAATCGTGCACATCCAGGCCGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTCTGGGAGGTGATCAGTGATGAACATGGCATCGACCCACCGGCACCTACCACGGGGACAGCGACCTGCAGCTGGACCGCATCTCCGTGTACTACAATGAAGCCACAGGTGGCAAATATGTTCCTCGTGCATCCTGGTGGATCTAGAACCTGGACCATGGACTCTGTTCGCTCAGGTCCTTTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAACTGGGCCAAAGGCCACTACACAGAGGGGGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTACGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGTGGAGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAGTACCCTGATCGCATCATGAACACCTTCAGTGTGGTTCCTTCACCCAAAGTATCTGACACCGTGGTCGAGCCCTACAATGCCACCTCTCCGTCCATCAGTTGGTAGAGAACACTGATGAGACCTATTGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGTACTCTGAAGCTGACCACACCAACCTACGGGGATCTGAACCACCTCGTCTCAGCCACCATGAGCGGTGTCACCACCTGCCTCCGCTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAATTGGCAGTCAACATGGTCCCCTTCCCACGCCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAATATCGAGCTCTTACAGTGCCAGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAAAACAGCAGCTACTTTGTGGAATGGATCCCAACAACGTCAAGACAGCTGTCTGTGACATCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGCGAGGGCATGGACGAGATGGAGTTCACTGAGGCTGAGAGCAACATGAACGACCTCGTCTCTGAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGCCGAAGAGGAGGCCTAAGGCAGAGCCCCCATCACCTCAGGCTTCTCAGTTCCCTTAGCCGTCTTACTCAACTGCCCTTTCCTCTCCCTCAGAATTTGTGTTTGCTGCCTCTATCTTGTTTTTTGTTTTTCTTCTCGGGGGGGGTCTAGAACAGTGCCTAGCACATAGTAGGCACTCAATAAATACTTGTTTG + 5988B2@6B?E1D5>1CFDG7=DFGA=<E@F?=:B>>8?C3@F?>EDB7EBDCA7(DD71.>A)F?*)365B:@A:<:99?>96=A*BACA?B=*6-7)BBAG8>DA6>;-8-5927B6?=>:CE?D&<8?;9869981>@9G;4==<@D@F8B8C9E@9>CC%9:>-4:@?<9<;/E=3;2A?:A:@B+=C99@/;<<=@<=:<88(:<68?8@FE:1>4D>@B@>=AC7A>@@5<9;6:8:68B==?AA>942?7>81:394<'6773;3)9;;840<2:9?=C.=7*@,1>216@;3//*>>@@=:;=>5C=5?2<.73?7??6=:9(==6:8A:879349795-A<@70<82>;5346530494849@>5<;??9:981:>5C6@A<8AED@567:E9@BB75<3-7:952%-6?;69??,<95,060=171932ED@<>8>CB5;?+6:>443:@7=<:9@16+39=C765@@<*=187@+;6%C7;>28@<8>?BACA>B9=+4:>@0?69D>D>;E<;A@D97GAA73@3A=,:67879>:/301?/B8>/1>AC;@C>F7;989:7::9-:.:BE<59&>A@:@??F8B=A>1<=G98A@3@DDB57?7?DD7C9@C*>@ED;>?D?E>G>=7>6@28AD=2>@E:@@87DCCCBD-;>9E>@B5F?';637?&@5836,=?:@?;?E9?70B;=A+A@=?A31;;6.417-=/;3=8:B?:?9D:E:+?8@:5:>8?C=<9@8>=?@&@B@93=>69A2B?;:<5@:B85=5:1B<7?>>?;?6=3C>E>88FCDB9@;:EE5B281;42B?;4<0'CD?>C<=AB?56<6%9=>?ABA@25B@B$<26=@6=4CB@4B-5@?;C78AE8<=;?1:;%<1+6?7;A7?9A<@.>@6;=B1.%6><1<3?@BA89F97;B=84262;(B8:9C;7B<9@AA0A@0??;?0AC@AADDACAED*;9:6,>2DDEB4>@CD7=@G;G(?7B.=1;>@DDC4)>?:A>;8;CFAE5FE?-58B@BB74?C0CD>1=@C@<<@45;AD>=:C<;<=CB@:;?@@*>=BA?>E?:B3DDC<>?EA(C@;;?>@CCC>2;?;E6<;A5E:C4BA1A0'@<56@@3B;?=7:8%6BFAC=@,?CCB:B<2)<:4ABBC9?A;A=:@A*>7.=1;9DDE34A::AB9B=?@(??7CC0?=?<-6=A@@>>E.E@5B<2@BCF@=)<@;0B@B3/9$<94668'ABB@;58@=@$99@>>=@;=8>B=EDD@C=1C>;:>;=<;;:??>AB>6C=*A?*:@A@B8GC+C?? @rCer/823/1665_58_CCS ATGGGGAGTCTGAAGCGTGGGACATGGACCGTTTCACTGGGATGGCAAGGGAATTCTGTCCCTGAGGACAGGACTGAAGCTGGGATCAAGCGTTTCCTGGAGGACACCACGGATGATGGAGAACTGAGCAAGTTCGTGAAGGATTTCTCAGGAAATGAGAGCTGCCACCCACCAGAGGCTAAGACCTGGGCATCCAGGCCCCAAGTCCTGGAGCCAAGGCCCCAGGCCCCAGACCTCTATGATGATGACCTGGAGTTCAGACCCCCTTCGTGGCCCCAGTCCGCTGACAAACCAGCAGTACTTCTGTGCCCCAGCCCCTCTCAGCCCATCTGCCAGGCCCGCAGCCCATGGGGCAAGCTTGATCCCTATGATTCCTCTGAGGATGACAAGGAGTATGTGGGCTTTGCAACCCTCCCAACCAAGTCCACCGAAAGTCCGTGAAGAAAGGCTTTGACTTTACCCTCATGGTGGCAGAGAGTCTGGCCTGGGCAAATCCACACTTGTCAATAGCCTCTTCCTCACTGATCTGTACCGGGACCGGAAACTCCTTGGTGCTGAAGAGCGATCATGCAAACCGTGGAGATCACTAAGCATGCAGTGGACATAGAAGAGAAGGGTGTGAGGCTGCGGCTCACCATTGTGGAACACCAGGTTTTGGGGATGCAGTCAACAACACAGAATGCTGGAAGCCTGTGGCAGAATACATTGATCAGCAGTTTGAGCAGTATTTCCGAGATGAGAGTGGCCTGAACCGAAAGAACATCCAAGACAACAGGGTGCACTGCTGCCTGTACTTCATCTCACCCTTCGGCCACGGGCTCCGGCCATTGGATGTTGAATTCATGAAGGCCCTGCATCAGCGGGTCAACATCGTGCCTATCCTGGCTAAGGCAGACACACTTGACACCTCCAGAAGTGGACCGAAAGAAACGCAAAATCCGGGAGGAGATTGAGCATTTTGGAATCAAGATCTATCAGTTCCCAGACTGTGACTCTGACGAGGATGAGGACTTCAAATGCAGGACCAAGCCCTAAAGGAAAGCATCCCATTTGCAGTAATTGGCAGCAACACTGTAGTAGAGGCCAGAGGCGCGAGTTCGGGTCGACTCTACCCCTGGGCATCGTGGAAGTGGAAAACCCAGGGCACTGCGACTTTGTGAAGCTGAGGACAATGCTGTACGTACCCACATGCAGGACCTGAAGGATGTGACGCGGAGAACACATTATGAGAACTACCGGCACAGTGCATCCAGAGCATGACCGCCTGGTGGTAAAGGAACGCAATCGCAACAAACTGACTCGAGAGAGTGGTACGACTTCCCCATCCCTGCTGTCCCACCAGGGACAGATCCAGAAAACTGAGAAGCTATCCGAGAGAAAGATGAGGAGCTGCGGCGGATGCAGGAGATGCTACACAAAATACAAAAACAGATGAAGGAACCTATTACTGGCTTTCAGCCTGGATATTTAAATCTCCTCCTGTTCTTCCTGTCCATGCCAGCCCCTCCAGCACCAGCTCTGCTCAGGCCCTTCAGCTACTGCACTTCGCTTACATCCCTGCTGACTGCCAGAGACTCAAGGAAATAAAGTTTAATAAATCTGTAGGT + -.422%005044,33//*02,'2%0/*00--('$+'++,'+/12..5+430*(.*31025603--4(12.2*,22..(30066362,0,0+//--1,1&,.0-(./1)+,.11,---/'*.2/.//')00*121010./,0)+'(*&&'(.*2-,*&%-.10-,.&./,+11*,)%1/1.*,/.,*-..(//+01/*&2.2,-)1/.&/0-*)-%*&-+/.0)/-$0.0*1.--*1/+,)'00.+(/+1./,+//,(+1-)0/11'0,'1,0,,,2,)001+01*,(&)*#.00/-)&-'//+00')+.,.$,,/-/*'0.0--,/&+--*42453+10'+.+-13)10145...)/.4/1-(45/4103'-&1/21340//11..110-(.022.,)./(1630210/.-%)31%3)1.404221,4.---$%+0+)%+5004-',.,4.)1*203111+,32+$+,-1*.($$-,/.12623-*-1'/33.111/,)13*,,,(,)/.0/...-/.13.-.60,%,,*.6/31/..,/+23/34023..00.2-/1.0*''&.,110+-02+64632-,04502120../5/4523*1'+/34424*0,1.,+-)0**-+.,0*0')(,.'&//+3,)/5($-0-,'.5-04,+)'3-2*2423502-.6..35-451132.2.*$(+*--,/**(,0'.+0102054/'..+1//,3-+*.54*)()650%'$)***%)))*1-5400,(,',%-2)/.+2/,,0.15012(*&+0/,///+)'&#,///%&(+.,,+*/.$((,'320*/103+)-2(3'2+.4.313243534)5)&))2/03364+.12)--2)241*/.,$,1/33450+)(-651005/0(2.2/131**,*.%/2+%2(/,),*2'*+,)(/+//2,54.12.+444-,515)04.-/-)21/(.1.053*/.01513.522/2351/)/).3(633-05522)241/1*)++*&/+/3-1&2&.3.'(.//6-0/03/142.234.0(32-..,.25+2/.+05/113-/,/(21//.+)/4-00.31+0.0+3,-0/&#)#,.+,0((/.'/20+41//+*-2'0,-)----))-(6..252321101*4/*$2463551+115020+3-3-,0.4/(420552)#.2.(,,/1)3312334//13+53624./)43..-*,/(1.()-13/30/04542-),)1*3#10451--3-+.*,*,/)/5111$(0+210,/+%34*0*4.0.35-245555442-).1203500,1402-0..'$'0(6/520+1.02*/5)*1./4*042166/46233/64.,120*035425-*2%.10(*452033,014251+,)-03131../230254*5-110-/0/',..1'01/442-'-.*$0,,)23..4+/,*)'003(155,5-/.%./'..*/3'66/42.($31)313.3/+41341412/',&/+000'12#/5422../-0113511/1+.0$1&4244210-0$0-/,0.$'*/).134245406102-0)-0.01-)/))4341)/35.245//-235/103510//1 @rCer/825/25_1642_CCS ATGGGAGTGCGTTACTTACCTCGACTCTTAGCTTGTCGGGGACGGTAACCGGGACCCGGTGTCTGCTCCTTCCGCCTTCGCCTCCTAATCCCTAGCCACTATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCCGGGCCGTGTTTGTAGACCTAGAACCTACTGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGTACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATACGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCCGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACTTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAATTATCCATTCCTTTGGCACTGCAGCATGTCATGCTCCAGGATTTCAGCTTCAGCTTAGCTGACAGACATTAAAGCTTTCTGGTTAGATTGTTTTCACTTGGTGATCATGTCTTTTCCATGTGTACCTATAATATTTTTCCATCGTGTCTCAAAGTAAAGTCATT + @F8BD>;7AE?@=@A@ECF?8FEFC>BED17BAB@6>E;7@9A-CA<-E?6A5182?DED@G;D8;B8?*??>;>&5B@8C4)@@?@C-A6977=A>CDBDEDBCE:?46?B>BB4B:6;?7?C>2=-D@;F:5;?4<=8>BDBD=696<>>FAEADF;EBCA?FA;FDC=F8G>;9,ADCEGCE9>CGAB?FA@DC:CCF>0>1C@DF9;85AA7B@;9FFEB@;6CE0CCBBBB@E?9DEE89:>33?CB7CE>C=9E5@ECBBE@BD=4;2::A?A3;:@C;78:9?A8ABBC>>?0GE>CE@CBDFC5D3F?;F8CFDF?7=:;*?E;5=B@C)@;FD6FFC@<>.B@=?4:EA@C:9>A3>@E?1><:@CCD6EDCCF@BB=@:E;:9D=FEA-F@EG?E?:BD@FE>8EA;FE>CGB0BDBEA:D;?AF8CDB87=8BEDCEGEE?F<>5@:,::?.C@EEB@CEE;1EC:>>B5AGB48;DEFD6CD@?AA?EEFD*EEACA8EEB9DB7BG8<4=B>'B;>E4CFDEBG>BAE@AEBGBEE=EDFF?8>=A>$9DB@7BEGCFDF:E>E@AD>@?@=>C8@4CFEBFEDGCEF5B@?;8?A5C5GEBDC@??BA>4=7CCF@A9BC?FA7>DE?@@:@?ABB9C:C>F:>DFGF<@;:;AF0A=DDGHE4DAC8DGBAFA=%G@?;EEA@G>I@0>GEFG=GFHDJFCJKGJFI>?G72A:?CEIEGDH@KKE@JHEFJDKAF>FBBDHEIGI=FHHHIIFDKEHAICKIDHIIIKKG?;?9HF;AI&FCF4EB@HEH7GFGGDHH:GBGH;BGBGI@KGCKKABDGEH;BI@FEBHK@HKHGJIHG@BDCDF<=A?IJEI0KKGB?BKCIKDKGJB9&>=HHGC8HB=D=JG@FB>JIII@BCKJ?G7KHEIICIKIKJKIJKIIIHKKFKKAKAC;F?DFIJHBFK9JJIKCKKJ=GJ4CEAIIDKBC:E?HH?G?I&JJHHJIEHHE@$E=8FGFGFAF@?;:B9;EDEDG9DAA,D@IH?CDHHGF9CABE)GF>D8IEDCIA>I @rCer/827/993_58_CCS CGTCCATCAGTTGGTAGAGAACACTGATGAGACCTATTGCATTGACAACGAGGCCTCTATGATATCTGCTTCCGTACTCTGAAGCTGACCACACCAACCTACGGGATCTGAACCACTCGTCTCAGCCACCATGAGCGGTGTCACACCTGCCTCCGCTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAATTGGCAGTCAACATGGTCCCCTTCCCACGCCTCCATTTCTTTATGCCTGGCTTTGCCCTCTCACCAGCCGTGGAAGCCAGCAATATCGAGCTCTTACAGTGCCAGAACTCACCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAAAACAGCAGCTACTTTGTGAATGGATCCCCAACAACGTCAAGACAGCTGTCTGTGACATCCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGCGAGGCATGGACGAGATGGAGTTCACTGAGGCTGAGAGCAACATGAACGACCTCGTCTCTGAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCCGAAGAGGAGGCTAAGGCAGAGCCCCATCACCTCAGGCTTCTCAGTTCCTTAGCCGTCTTACTCAACTGCCCTTTCCTCTCCCTCAGAATTTGTGTTTGCTGCTCTATCTTGTTTTTTGTTTTTTCTTCTCGGGGGGGTCTAGAACAGTGCCTAGCACATAGTAGGCACTCAATAAATACTTGTTTGT + KKKKKKKKKKKKK8KKKKKKHJKKKKKKKKKKK+KKKKKKKKKKKKKEKKKH&K(KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKJKKBKKKJKKKKK/KKKKKKJKKKKK2KKKK3KDKK'KK:KKKKKKKKKKKK3KKJKKKKKKK=KKKKKK0KDKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKK)KKKKKKKKK1KKKKKFKKKKKKKKKK>KKKKKKKKKKKKKKKKK?KKKKKKKK:KK?KHKEKIKKKKKFKKKKKKKKIKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KKKKKKKKKKKKKKK#KKKKKKKKKK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KK*KKKKK;K-KKKKJKKKAKKEKKKK7KKKKKKK;KKKKKKKKKKKKKKHKKKKKKKKKKK-KKKKKKKKKKJKKKKKKKKKKK3KKKKKKKKKKGKKKKKKKKKKKIKKFKKKK$KKKKKKKKKKKKKK5JKKKKK>KKKKKKKKKKKK&KKKKKKKKKKKKKDKKKKKHKKKKKKK/KKKKKKKKKKHKKKKKKKKKKK @rCer/828/25_2191_CCS ATGGGGCGCTGCGGCAGTGAGTGTGGAGGCGCGGACGCGCGGCGGAGCTGGAACTGCTGCAGCTGCTGCCGCCGCCGGAGGAACCTTGATCCCCGTGCTCCGGACACCCCGGCCTCGCCATGGCTGACCAGCTGACTGAGGAGCAGATCGCAGAGTTCAAGGAGGCCTTCTCCCTCTTTGACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGACAGTGATGAGATCCCTGGGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGATGCAGATGGGAACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATTGCCAGAAGATGAAGGACACAGACAGTGAGGAGGAGATCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAACGGCTACATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGAGAAGCTGACGATGAGGAGGTGGATGAGATGATCAGAGAGGCTGACATCGACGGAGATGGCCAGGTCAATTATGAAGAGTTTGTACAGATGATGACTGCAAAGTGAAGGCCCCCGGGCAGCTGGCGATGCCCGTTCTCTTGATCTCTCTCTTCTCGCGCGCGCACTCTCTCTTCAACACTCCCCTGCGTACCCGGTTCTAGCAACACCAATTGATTGACTGAGAATCTGATAAAGCAACAAAAGATTTGTCCCAAGCTGCATGATTGCTCTTTCTCCTTCTTCCTGAGTCTCTCTCCATGCCCCTCATCTCTTCCTTTTGCCCTCGCCTCTTCCATCCATGTCTTCCAAGGCCTGATGCATTCATAAGATGAAGCCCTCCCCAGATCCCCTTGGGGAGCCTCTGCCCTCTCCAGCCCGGGTGGCTCTCCTCCATTTTGGTTTGTTTCCTCTTGTTTGTCATCTTATTTTGGGTGCTGGGTGGCTGCCAGCCCTGTCCCGGACCTGCTGGGAGGGACAAGAGCCCTCCCCCAGGCAGAAGAGCATGCCCTTTGCCGTTGCATGCAACCAGCCCTGTGATTCCATGTGCAGATCCCAGCAGCTGTTGGGGCAGGGTGCCAAGAGAGGCATTCCAGAAGACTGAGGGGCGTTGAGGAATTGCGGCGTTGACTGGATGTGGCCCAGGAGGGGGTCGAGGGGGCCGACTCACAGAAGGGGACTGACAGTGGGCAACACTCGCATCCCACTGGCTGCTGTTCTGCAACCATCCGATTGGCTTTCTGAGGTTTGGCTGGGTGGGGACCGCTCATTGGCCACTCTACAAATTGGACTTGCCCGCGTTCCTGAAGCGCTCTCGAGCTGTTCTGTAAATACCTGGTGCTAACATCCCATGCCGCTCCCTCCTCACAAAGCACCCACCGCCCTGAGGGCCGTCCTAGGAATGGATGTGGGGATGGTCGCTTTGTAATGTGCTGGTTCTCTCTTTTTTTTTCTTTCCCCTCTATGCCCTTAAAACTTTCATTTTGTTCAGAACCATGCTGGGCTAGCTAAAGGGTGGGAGAGGGAAGATGGGCCCCACCACGCTCTCAAGAGAACGCACCTGCAATAAAATAGTCTTGTCGCCACTGCCCAGGGGACAGCAGCTACGGCAGCCTCTGCGTCCTGGTCCGCCAGCACCTCCGCTTCTCCGTGGTGACTTGGTGCCGCTTCCTCACATCTGTGCTCCGTGCCCTCTTCCCTGCCTTCCCCTCGCCCACCTGCCTGCCCCCATACTCCCCCAGCGGAGAGCATGATCCGTGCCCTTGCTTCTGACTTTCGCCTCTGGGACAAGTAAGTCAATGTGGGCAGTTCAGTCGTCTGGGTTTTTTCCCTTTCTGTTATTTCATCTGGCTCCCCCACCACCAACCCCCACCCCTCCCCGCCCCCCTGCTTCCCCTCACTGCCAGGTCGATCAAGTGGCTTTTCCTGGACCTGCCCAGCTTTGAGAATCTCTTCTCATCCACCCTCTGGCACCTAGCCTCTGAGGGAAGGAGGGACGGGGCATAGTGGGAGACCCAGCCAAGAGCTGAGGGTAAGGCAGGTAGGCGTGAGGCTGTGGACATTTTCGGAATGTTTTGGTTTTGTTTTTTTTTTAAACGGGCAATATTGTGTTCAGTTCAAGCTGTGAAGAAAAATATATATCAATGTTTTCCAATAAAATACAGTGACTACC + ,#&,,06788:8&24664645:::9;.,5231(49979:96;:474041,859,718-34625:9365/53152/7*4809%(%528:76*9999255&7906387*88'#8,3499.9364:49:908557.4-144.0:40/4/3673788597:257/:86:.94:05-989:5:;:::34,9:1-9:654,375:78:75)69/4-7.37+-0'77225824:85,126%774%778:856:,4:984535968254:868852*/5531/5//43)417.&45&+3::46:3(55,640&215;::/5;6;7)8::8;473;+5?<774'&+7;1+%40.2603):69;;48539;=<63=75=3::3$8;*:3>;>7>:;9::1%3;8:;;5:0=:0/=88==071.;=5879=68=?>>8:<7:8<9=><89:725<35=:4?&24%565/,.5=;:16$8;=;>09<4>84>;4=9775263:9296;278=99,:8<=7//<877:.:1702:=:592767<3>:772=?><94956.:;279<;9<:??<;?>;9;+=7<>89>8/<;=;?8;>2;8=:99=:.426==;9-8<45-+8/3/44'.797..6952388,:>9>;9;70:;:667973%.5')6>=6:;<$768::3=4::<9:/8:<99;6=9;;?<85;?92129/;9=;9<=:8>2;;:?852;;;7:>=?;739.=668/:3;9<<$8756242147:96=>45)99643/=;93327<2??>7+>=0<777/7122:88693==54';8?:?.>4=:5684<<1>18?;=76145<786;:*;=>:7570:;=4>&7;;=<6?67:81>;2+<==;:6??,;:;1=7477'5=4852=<<8;7??;56?,<;4299/>72/32=>9<<.777,7:4867$600*-1565:57/84840*3)$2026,-(0&*,3%3,-+(1/1&).42),.1080897-.53312/*(-12(41&$)/,9749-08-9*734*4664.4,343/323548:69419934424,234:094163/5*/0385:5694,4766:6754/.&/3'275467:55;/96:-3-99:87:9.45743-4581926)156,2-+6545456.+:5543157'303-2438)7643236558::1:73*8986/5:438140707771'81-42371205;-99/18793;3:62:777:748)87,7132879.58:48;:4/86$6*6-551144+57:;3:,40:7;:.-98586;5:2957565576::6:6/47/6159.1:::87;46;432-4:::7-976465;90:7;;6705648099467113:122,1*-44%3-+2-/,189.72530:16543882,0086587/95769;86552.5:299971,$356102631.74%778343.3%/697:(39:8.64*1&00443476448-6839:8'866:7::5499-:5-+5.,62*66,6302*75-:7800.0::8:66:3;67969474:7:7699;6&26459::4.6944%-:5,26*534(35849:::62727317:65-5697::553:5,38)6836.0533:3$16536:44:::.859:9-5'24811655:,457-28::66'1862:788,6456584;60625+&#%/.5+)'655306:4:58%4764569-/'5236554.0/6:66468868;:99-33360-.38:6:.0964:475'0-333659:5.1,1/-66480465567755553/96:3:4'5545'#//0893061,#2.811745.4,3-531.)./2-3-.-10357*0-34*4742%2/04514507%4646790/5&/+.30125.4%1*2$00+566*.4)2,,-*-$*-+'2*679864551717;67:5.4:76878543:8608758.98:959-877;,6674:4919993-)234+7.--11:;9656.899:4085.297%6%7/3297:4938::94:3-4509:5819764387;::3:/83805997'7646659898::'2:;::;:88:559*4714.6767:7459:35+'9867286596486;18/::8-879:5;:94::3:-93)0666 @rCer/829/2306_57_CCS ATGGGACCGCCCTATGGTCCCGGTTTCTGCAGAGTCTACTTCAGAAGCCGAGTCCGGTTTGGGATTGCCAGGCTGTGTTAGTGAGTCTGAGCTTGTGAGCGGCTGTGGCCCCAACTCTCGCCAGCATAGCATCCCGGCAGGAGATAAACTACATTCAGTTGAGTCTGCAAGACTGGAGAATTGGGGTGATAAATTCATTCACTGTCAAGTTTATTGAAGTCAAAATGTCCAAAAAAATCAGTGGCGGTTCTGTGGTAGAGCTGCAAGGAGATGAAATGACACGAATCATTTGGGAATTGATTAAAGAGAAACTCATTTTTCCCTATGTGGAATTGGATCTACAGAGCTATGATTTAGGCATAGAGAATCGTGATGCACCAACGACCAGGTCACCAAGGATGCTGCAGAAGCTATAAAGAAGTATAATGTTGGCGTCAAATGTGCCACTATCACTCTGATGAGAAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGAAATATTCTGGTGGCACGGTCTTCAGAGAAGCATTATCTGCAAAAATATCCCCGGCTTGTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTACGGGGATCAATACAGAGCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAGTGATGGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAGAGGTGGTGGTGTTGCCATGGGGATGTATAATCAAGATAAGTCAATTGAAGATTTGCACACAGTTCCTTCCAAATGCTCTGTCTAAGGGTTGGCCTTTGTATCTGAGCACCAAAAACACTATTCTGAAGAAATATGATGGCGTTTTAAAGACATCTTTCAGGAGATATATGACAAGCAGTACAAGTCCAATTTGAAGCCCAAAAGATCTGGTATGAGCATAGGCTCATCGATGACATGGTGGCCCAAGCTATGAAATCAGAGGAGGCTTCATCTGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCTGTGGCCCAAGGTATGGCTCTCTCGGCATGATGACCAGTGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAACTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTGTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCCGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGACAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATAACTGGCTGAGGAGGATAAGTGTCTTTTGGTAACTAGGTCTATAGGTTTACATTTTCTGTATTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGTCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTCTTATATATACAGTTATTGCCACCTTTGTGAATGTGGCAAGGACTTTTTTTAAAATTTTGTTTTATTTTCTAGTACCAGCCTCAGGATTTGGTTAGTACTGATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATTAAGATTGCTCAAAAGGGTAAATGATAGCACAGTATTGTTCCTAAAATATGCATAAAGTAGAAATTCACTTCCTTCCCCTCTGTCCATGACCTTGGGCACAGGGAGGTTCTGGTGTCACAGATGTCCCGTTTGTGAGGTAGAGCTGTTAAACTTGCACATGACTGGAACAAAGTATGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGAGCTTGCTGAATGTTTCCAATAGACTAAATATTGTTTAGGCACAGGAGAGTTTGGAATCCAGAATAAATACTACCTGGAGGTTCGTCCTCTCCATTTGTCTCTTTCTCCCTGGCCTGGCCTGAATATCATGCTACTCTAAATATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGCATCTTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTCTGTAAATGTGATTTCTCAGAAGTTGATATTAAACACTATTCTGGTCC + KEEK$AF/@GK4AE8C2DKJ+J-CK@KIJKAKKKIFG>HH7KKKKEAI9KKKKK:J6KK>CK*IKCIK+JJ'G@HD?KEHIGKKIKDKKKKJKDKKGIAKK1F?>G?(KKK*;4HB&@D4KFHFKDKKKHHJKKKIKK,KAIGKKKHKJ?KKIJKDKJJHIJKK4IK=FIJ2JK)KDI-F%DHCEKJKHGJKDEFBIKK9KKGFHKIIFJKKIHEJBKBG-FG,H?JKKK3KK6IEGK)K:K@KH@JJKJDKKAKIHJIHG*F@6FIIGEGADE9@0IJJKKJ7CIHGHKJKEJKKK1FFIKKJ%*+BKJKKKIDIKKKAJGA$JKJJE7DBK4GI*KKKKK(JFJKKJGEIFK;BGKKGHKCK7KIKK,DKHH)FGJJKKG=KJKKFHKJKK;KEK6K7IK9JJ;H@EIHH=BA-IJKK2@E6IJ>;HJFJ=IKJ2KIJKGKI7AH@3K;@HFA:KKK;KIH'=>KKHIKGKKHIJAIKIKJK8GJKKK,CK+IG+G=IIIKJKKK=KJFIKKK2JIJJIJ<9,EEJIJFEIKKKKK@JKFKHHDICFG&J6<%HKJK97EJGICFI=E?B?GJKHJ?FKIIGC:IK3KIHJKKKKJKKK,GKCKCIKGFIKJG=KJKKKAKKIKJ+E=KK)IKIJKK:H4IJIGDCKG.E;EIJKFF+KKKKEF,KHKK@K2GKJGJ?CKDKJKIGKCKKK8HKEJKGFK9KKGKK>KHKKHKJIKKIKAK<KFHI?HIKJKKHHIIKJKKKKEJBJK1HKBK@IFKHJ5HKKKJ:?KIIJ?K9KHBIGG1K;>KGKKJKCKKJ/FDJKH6KE1HKK?9IHAKKKK4=0JK1-JKK)J4=IGJK'KK2KKKKKK$=?CEHJ=EJIJIHKBJ0GIKKCJ5@IFE*KKK+KKK9GDKJKK;JKK9IHKK7KKIHJIKKBJKEKKK:BFKKKFKKKFJJKJK6JJJ%IKA@:FCHGBHAHK3KKJJI$FI,KKFKGKK@KGIKGKKCK.:8KKKJKK/KKK5KKKDIKJJ>KDKK'KHIHJJK7JKIKKKKK/KKK8KCKJJJKHHCJHIK2FE7;3ICIF?J=JK5HBBGBI?=0GJIGKKJI9F$GKKH4HA(355>=8C-DCFDG>F8KB:I;>BFHEIEFI:EG-BFD:BH:ABJ2;KH;B8(%D@EE'EKI=JJ@IGI;@D6ECEDIAF6CHHD?B0FJ0A>)AHF7DEHDDHK>7ABJ)>K3K>GG(C-KKK>9=HJHGCFEEC8?@GG3B@DEIIIGJHK5>@HI1I?IG@HD6@I7F7EH3GCHHIJIJJJJKJH)@'CEE>=?HC@E3H>HCAEG)?HA12DHI%EEJHGD=BE1FKHG1AH=GGHEGJGG>G<>;EK:G@$?BDEEEF@@DEDBB7A>D:FBA<=DCG?BB?@CDE:E:ECEACBD@EFAB>DC7=DGAFC@?=BEC;DBFF0@,:;9>A&C@CBB3B=;<;0A=@A<7B?7;=@9??B=AABC>7A;?;?9><@A=<<:B@AB?<=8?>>@77<9?;9;?=A0A3BAA99>92=?BB@>?.=88'A=4B@A?A>>/BB??772>@>C>B>?>>8:B@ACCCA@8@?AC?+>B?=@@)?6A;@=<6@A3=@:6B@=7=1=7;?:7???<@B?>AC<>A/>8><@<=CC?A:A:>>46*<:;)BBCC>B8A=B@;?1BCA?CCB>BAA3>>CBB?>@:>B?@A885@6B;@<@C?>>@@?A/>@@B:B=@;>C>@:@@BC>?@C@@???C;3=<<<(7:>-CB@>=>A+:@B?B9C<<>?A7ACAC?=?B8@??14>9==A=@A==>BC9A;?B?:=C=BC@C?A=A3@1>>,;A>;@AB=>>>>@<-?=?>?<:?8@6>=>A????><<>=AA?>6@??CB;;6>@9?;A@>AA?C9>8)4BB@;<2@A@7>A??:19?46>?6$=?<79@?69=@BCC>?0@?<>?B@>8=B?A@CCAA?A2B6::@BA==5;BC?93:A=@C??=>,?B;?@@B=@6?83:=56>4?69?>AA@=8?A7>;@?C>:>@;>77<>6>AB?=A.<=@A8@A>3<6=@?==>:A>7;AAAACC;CBCAB@0;9<;>B?>@@:C?CAA@AC8>=>;B;C@?>?8=,AA<=<=@A9:;&@B8?90?6>A=5:@A8AB@@A==?@BA=A=.<@;/;@7ACCA@;A+9@B;:?A@1C>AAB9A;:A8<=BC?C<6:7=<>4:0/8?@?0@>AB8CA=:;BB:=A9?78977=BBCACB????>%@?AB7;9@>?@@C:>:=4>5@CA?=;3>>2?==:ACB@=7?>1:?5@7>>3@>AC?C6C?39@>/A=@@?>A>@;CCC@A?6A>?B8B>ABA8BAA>;=?>5A>;?A@<8=7?B>CB=@/<5<;9&4B=@CAC@=BACBA?B>BA8=<:C?A?@?C<@@B=B<=7<>6@?A;A:>?>=>>(A;?A?0@>;;5?8>7><;@?><:A3A>9?8:A=4@>7>@?BA@:;>-@8AB>@@B><=8<<8B@C@CA@B7==AC?AC;B;A:6C>9CA@AB7A@BB7ACA@9:<@<27AA8<>@A=,<@?2<92A@=<;A8<@BB6=A=?;<9578/94<>>1B3A@2@CCA=B85B>BB=A85;118;<>:40;:18=>8:809<:8:730*699<9<9882134==-;8;?<=8=>>=?=9?;<>7>>9==<18<=>>?><=9>>=>??>=>==>>;::*<:<7:7$<<:70=9<>;957;825;(?:;?>89=:?><6>>==::<8?8*<>?;875<:=8>>>>-8=>>:,0:1=6::86:;2<>;5<92>;464>>>>3:2:86<:88<6;4:?=>95;??5=78:>?;3392=;5;<>;?:6>8/;6<3>?9<>?;??>?<9;9><9>6:68;>=0>9==/.>=<::<<6?<9?>;297849<>>9==>/<>7:3=:>8<<>4>??69>;8;;;(<=:5;;=57=69>?==<88;:+9>?>??>>><=>?;;:><59846?<4<9>35;(;>>:,:=:?<7:94=97==+;8<;815104:?;7?=680;:9:;;&5=<;<=<:=>====>;:>;?3?::<<9;:;?>8<>>=9=9>=05;:<<:88?>=;<99:>=>>9<8==?;:><&=;;':=974;( @rCer/834/25_1850_CCS ATGGGAACGCAGAGTACATGGGCACCCGGCCTGATAAAGCGCGCCGACTGGGCTACAAGGCCAAGCAAGGTTACGTTATATATAGGATTCGTGTTCGCCGTGGTGGCCGAAAACGCCCAGTTCCTAAGGGTGCAACTTATGGCAAGCCTGTCCATCATGGTGTTAACCAGCTAAAGTTTGCTCGGAGCCTTCAGTCCGTTGCAGAGGAGCGAGCTGGACGCCACTGTGGGGCTCTGAGAGTCCTGAATTCTTACTGGGTTGGAGAAGATTCCACATACAAATTTTTTGAGGTTATCCTCATTGATCCATTCCATAAAGCTATCAGAAGAAATCCTGACACCCAGTGGATCACCAAACCAGTCCACAAGCACAGGGAGATGCGTGGGCTGACATCTGCAGGCCGAAAGAGCCGTGGCCTTGGAAAGGGCCATAAGTTCCACCACACTATTGGTGGTTCTCGCCGGGCAGCTTGGAGAAGGCGCAATACTCTCCAGCTCCACCGTTACCGCTAATATAAGTAAAGTTTGTAAAATTCATACCTAATAAACAATTTAGGACAGTCATGTCTGCTTACAGGTGTTATTTGTCTGTTAAAACTAGTCTGCAGATTGTTTCTTGAATGCTTTGTCAAATTAAGAAAGTTAAAGTGCAATAATGTTTGAAGACAATAAGTGGTGGTGTATCTTGTTTCTAATAAGATAAACTTTTTTGTCTTTATCTTATTAGGGAGTTGTATGTCAGTGTATAAAACATAACTGTGGTATAATAGGTTTAAAATAAATTCTTTAAGAGAACTGAAACTAGCCCTGTAGATTTGTCTGGTGCATGTGATGAAACCTGCAGCTTTGTTGGTGATGGCAATGCTGTGCTGGTTTACTTTCAAGTGGCTGGGTTTTTTTAGTTTGACAGGTACAGACTTTTTTAACTGGGCTTTAGAAAATCTGGGTTAGCCTGAAGAAAATTGCTTCTGCCTTCATAGTACCATTTTAAATTCACATAAAAAAGGTGAAAGCTCCCTAGTTCAGTGCTGTGGCTTCATGTAATTCAATGATTCGTGGTAGTGGTATTAATACTGGTGTGTTTTGAAATTGAATGTGAGATAAAATTAGCCTTAAGATTGGTAAGCTAGCAATGAATGCTAGGGTGGGAAGCTGGTAAGCCAGTGGCCGTTAGATAAATACCTTTCAAGTGTGAGAAGTCAATCCTAAAATATTTAACCGTAATGCTAATTGTGATCATTATGAATCCTTTCAGTCACATTAGAGGGGAAAGTAGTTGGCTATAAGTACCTCATTCTTAGTCCAGTCAGTCTTAAAAACATCTTGGTTACCCATTCTGTGCACTCCCATAGGCTACAGAAAAGGTCATAAGCGCATGGTTTGCAACCGTATGTGTTTTGTGCAGTTACTTCTCTTGTTCTTGGCCAAACTACCCTAAAAATCCTTACCATTCCACAAAGTTGGGCCATCACTTGTGCTCCCAGTTTGAGTACACCACCACATTGCATTTCTGTTTCTATCATGTCTTCCAGGAAACTAGACTGTTTCCCAGGGTGGATTTGAGTATAAAGAAAAGGTAGACAAGGAATTGCCCAATTCTAAATTCTGACTTTACTGACTTAAATCTAAATGCTCGTTTCTCTGAACCAATTTTCTCTGATCTTCTCTAGGGGTTTCAAAAGGCTCAGTTAATTGAATTCCAGGAAGTACTCAGCAAGTTCATAGAAGTTCTTGAGACCTAAATTTCTTCACACACACAAAAAAAGATCTTAAGTCATACATTTTTATTGTGTAGAAGTTGTTCAACTAAAGGAATAAATGTCTAT + IJ-KIIKKJKFJJIG9JKK0KKGEHJK1K=KDKKG8KJJHJKJKKJKKJGKKK?JKBKIK7KIKKIKKJKIKKKKJKKFKKKIKGKIDKGJKIKKKKKKKKKKKIKEKJ:KKKKKIKKJCGKFKKFKJKKKKKCKKDK?I1KKHKKJKJKJAKKIKKHKKJK>KHK?KJKKJDKKKBKKKKKJ>KKKGKIKKKKKGKKKKKKKKKJKKKK?KFKKKKKKKJKGKKKJ>KKKKKKIKKKKKKAKKKIKHKKJKKKKJKKIKFKJ<@;JCC8I>DJII9KK>HKDJJDF>KKHKKKIKKJHJKKIKIKJDKJKEKBKEA6FFKEHAK3KK6KHAKGEFKK?K;KJ@GBBDCH@@K7IHEK=KI?FF;KAKJKKK91J2IGJEHIIGIHKKHKKKCAKKKJ>KJF:KKKKKKKKFKJKJK=KE=IAGKKKKIKKJJKGKKKKGKKII,KKJBIJCKKJKKKKHJIDIKKDKAKKGKKKGBKKAKKEKKGKKHKHKGIKKKKJHF97KKKKKKKKJKKKKHKKJKFKJIK%KKKJ=KDKIKGJ5FE@KKKKKKKKKEKKIKKKKKKKKAKKJKIKJKDKKKKKIKH>3EKKKKKKJKKJKJFKDKFICHKKKKJKKGKKKJJK4IIFJKJ>KKKJFKKKJKKJKJKKKHCKJJDKKKK8KKJGK6KKKKKGJKHIJJJKKKKIKIKKKKKKFKKKBKKGKKK/KKKJKKCHKIFKKCIHIKKBKKKKKKIKKKIKJKJKIKFEKKKKK@KJKKKKKKJKKKKKKKKKKJKKKKKKKJJKKKKKKKKIKKJKJKJIKKKFKK?GKKKKJHKIHKKJI8KKKKKKKJKJBKJKIKKKKJKKCKKKKKKKIKKKKK@KKKKKKKK?KKK@KKEKKKKIKKKKKKJII @rCer/835/1854_60_CCS ATGGGGAGGAGCACCCGCCAAGCTCTGGGTCAACGTGGAGGTGCCAGGCCACCATGCTCAGTCTCAAGCTGCCCCAACTTCTTCAAGTCCACCAGGTCCCCCGGGTGTTCTGGGAAGATGGCATCATGTCTGGCTACCGCCGCCCCACCAGCTCGGCTTTGGACTGTGTTCTCAGCTCCTTCCAGATGACCAACGAGACGGTCAACATCTGGACTCACTTCGTGCCCACCTGGTACTTCCTGTGGCGGCTCCTGGCGCTGGCGGGCGGTCCCGGCTTCCGCGCGGAGCCGTACCACTGGCCGCTGCTGGTCTTCCTGCTGCCCGCCTGCCTCTACCCCTTCGCGTCGTGCTGCGCGCACACCTTCAGCTCCATGTCGCCCCGCGCGCGCCACATCTGCTACTTCCTGGACTACGGCGCGCTCAGCCTCTACAGCCTCGGCTGCGCCTTCCCCTATGCCGCCTACTCCATGCCGGCCTCCTGGCTGCACGGCCGCCTGCACCAGTTCTTTGTGCCTGCCGCCGCACTCAACTCCTTCTTGTGCACCGGCCTCTCCTGCTACTCCCGTTTCCTGGAGCTGGAAAGCCCTGGGCTCAGTAAGGTTCTCCGCACAGCAGCCTTCGCCTATCCCTTCCTGTTCGACAACCTCCCACTCTTTTATCGGCTCGGGCTGTGCTGGGGCAGGGGCCACAGCTGTGGGCAGGAGGTCCTGAGCACCAGCCATGGCTACCACCTCTTCTGTGCGCTGCTCACTGGCTTCCTCTTCGCCTCCACCTGCCTGAAAGGCTGGCACCAGGACGCTTTGACTACATCGGCCACAGCCACCAGCTATTCCACATCTGTGCAGTGCTGGGCACCCACTTCCAGCTGGAGGCAGTGCTGGCTGATATGGGATCGCGCAGAGCCTGGCTGGCCACACAGGAACCTGCCCTGGGCCTGGCAGGCACAGTGGCCACACTGGTCTTGGCTGTAGCCGGGAACCTACTCATCATTGCTGCTTTCACGGCCTCCCTGCTTCGGGCCCCCGGTACATGCCTCTGCTGCAGGGTGGCCCACTGGAGGGGGTACTCAGGCCAAACAACAGTGAAGCCCATCCCTGACCCTGCCCTGGAGGGGGCAGAGGCCAGGCCCCGTGCTGAGGAGGAGCCCAGAGTTGGGCCTAATCAGGTGGGACACATCTCAGCTGGAACAACAGGGCTGAGGAGAGAGGGCACAGGAGAGGGCACAGGAGAGGGCACAGGAGAGGAGGGGTGTCTAGGGAAATGCAGAGTGTGAGCGGGACTGTGAGGGGGCTCTTGATGGGAGTAGAGGAAGTGCTGAGGGTCTTGAGAGGGAGATGCATGCGTGTCCAGGCTGAAGATGCCCCCACACTCTGTCAAGGCTGGGGCCAGGAGGTGTTGGGGTCCTTTCATCTGGCTCCATTTCTGGTGCTCCTGAAGTCTCTGCTCAGCACAGGGAAGAACTAACACGACTAACCTAGGCCTACCCCAAATGCTTCTTGCTAACCAGGCCGAGAGGCCACACACTTGCCCCCCATCCCCACAAACCAGGTAATGCCAGTTTGCCAGCAGCTATTTGCCTAGAGAGATGAGTCTGTCCTGGTCATAACTGTGTACTCAAGGTGTCCAGGCTTTTGGGGGTGGGCCTATCTGGTGCATTGTGGATGGTTCAGTGGATTGAGGTGTGGGAGGAGGGTCCTAGGCTAGAGGGGGGATCCCTAGTTAAGACTTTAGGAAGCCACCTTCAATGTTTTCTGGAACAAGGCAGGTACAAATAAAAAATAAAACTTTGGAAAG + 98688.572599366547)906565614)4:5234435365636415.62261+10,+54444105052154./(2,+0-14*54&520+/2156516266342(01422255)62,31//420('11054610*42/22.3200%565354,44*/35-6155141/4/02*.1556+6452541220656..54104515664466654.1441444-413154/155.1,-0.1.5/54163555404-164645665563+/42,35.0/.2)4055266255666564213,/.-+/21565324/5*524465566,363-567:794:7:57575::55957:959::8951997;67/6::;6:993-7987*6414:36014649557:65685720:5:6979:259:5.53.8;8:9/0:9696863.889630-1179:-%53/:038+2678689957*8*:,0529:02--585;9515906:,88455;7992-/:8;6:9969;4:6578:95:6667::60:80:686;4;849:77996023526&79:0:47:5949::/;;4:97979;6463.429074947*88545:88685:59795:95897:3;763/9;:85638/-68:9/:88:89:39:67.959;;2965:::9:9:-8:849.;55:6::9:777*998.882:9-9468:562)5;6788*957;8637439597737:2&87:83838:529/01578/557537%785:8;549::0;996;585:65:465:966-5897:299.8);8:::994665.74089564.969989:9939:78:;936479/989/948546:34+&4568:854*9756*753:8:958585824598:786794:2-/46795;95)9798/579+9,8:.96:75:58637.635::8:8)8:;58.774-9:8134-5.8551844:996:321)39::.::792305):*::7;95:7788850:3-34/4.4#+3088::::;;4682;;78774737773#.4806598;776'45.9:6/891269%59::.:789945844(6;688:::):9/::7;67809::.839955:96/2*/386&45998'84*93570-801/+78'79696+671457%22:4&703198%89397(0153*68*9758;86.9::)3:95;6666:8+.*09;8/.6/-7::;499796558'6633#032/9493992999(983948994,6(5*88/::6;;865::736)5246::5824:574:/)+,%/0)/9:36996:890059877369:;666:89888*78:644>>89?=?7:879:*9212+:/892>/;98+8;63?;==>>>?771?987546+6739:;:2758+9==<;99>;<>9:7>>?=7>198>=<<28;8:676>4;7>>?590;;=7:6??7<7;:5:?96=;=6=80?=>5>>69:+<3><>>=>057:<:,=9>;5?9:<76=436:2;===1::/9<62=;26=?68;.966=>>>>;97741-69?:>>-9<;8?/8:27<8175<;:24;=7>79>99:::+687;&:::,:)=;99:;$44956(99?2>>?;=9465>;34458>?<2<1;:&6<+63:(9=-04:4*827<6:97:(<;::)3<8>:=19<=?;=6>6;558,9:9:75?=;8;<7(2:85:<==9?88903=;:6460277;8'.7:=08::-988931 @rCer/837/25_2936_CCS ATGGGGCGCGCGCAGCGGGCCGGCAGTGGCGGCGGAGATGGAGGAGGGAGGCCGGGACAAGGCGCCGGTGCAAGCCCCAGCAGCCCCCAGCGGCGGCCCCCGGCGGCACGGACGAGAAGCCAAGCGGCAAGGAGCGGCGGGATGCTGGGGACAAGGACAAAGAACAGGAGCTGTCTGAGGAGGACAAACAGCTTCAAGATGAACTGGAGATGCTCGTGGAACGAACTGGGGGAGAAGGACACATCCCTGTATCGACCAGCGCTGGAGGAATTGCGAAGGCAAATTCGTTCTTCTACAACTTCCATGACTTCAGTGCCCAAGCCTCTCAAATTTCTGCGTCCACACTATGGCAAACTGAAGGAAAATCTATGAGAACATGGCCCCTGGGGAGAATAAGCGTTTTGCTGCTGACATCATCTCTGTTTTGGCCATGACCATGAGTGGGGAGCGCGAGTGCCTCAAGTATCGGCTAGTGGGCTCCCAGGAGGAATTGGCATCATGGGGTCATGAGTATGTCAGGCATCTGGCAGGAGAAGTGGCTAAGGAGTGGCAGGAGCTGGATGACGCGGAGAAGGTCCAGCGGGAGCCACTGCTCACTCTGGTGAAGGAAATTGTCCCTACAACATGGCCCACAATGCAGAGCATGAGGCCTGTGACCTGCTTATGGAAATTGAGCAGGTGGACATGCTCGAGAAGGACATTGATGAGAATGCATACGCAAAGGTCTGCCTTTATCTTACCAGTTGTGTGAATTATGTGCCTGAGCCTGAGAACTCAGCCCTACTGCGTTGTGCCCTGGTGTGTTCCGAAAGTTTAGCCGGTTCCCTGAAGCTCTGAGATTGGCATTGATGCCAATGACATGGAGTTGGTAGAAGACATCTTCACCTCCTGCAAGGATGTGGTAGTACAGAAACAGATGGCATTCATGCTAGGCCGGCATGGGGTGTTCCTGGAGCTAAGTGAAGACGTTGAGGAGTATGAGGACCTGACAGAGATCATGTCCAATGTACAGCTCAACAGCAACTTCTTGGCCTTAGCTCGGGAGCTGGACATCATGGAGCCCAAGGTGCCTGATGACATCTACAAAACCCACCTAGAGAACAACAGGTTTGGGGCAGTGGCTCTCAGGTGGACTCTGCCCGCATGAACCTGGCCTCCTCTTTTGTGAATGGCTTTGTGAATGCAGCTTTTGGCCAAGACAAGCTGCTAACAGATGATGGCAACAAATGGCTTTACAAGAACAAGGACCATGGAATGTTGAGTGCAGCTGCATCTCTTGGGATGATTCTGCTGTGGGATGTGGATGGTGGCCTCACCCAGATTGACAAGTACCTGTACTCCTCTGAGGACTACATTAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCCTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGTATGGAGGTGGCAGGTGTGACAGCTCTAGCCTGTGGAATGATAGCAGTGGGGTCCTGCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGACACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCTATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAAGAAAAGAAGGACAAGGACAAAAAGGAAGCCCCTGCAGACATGGGAGCACATCAGGGAGTAGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGAGGAGATTGGTGCAGAGATGGCACTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCGTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGTACCCTTACCCTCTGCCCCTACCACAGTGACCGGCAGCTTATGAGTCAAGTGGCCGTGGCTGGGCTGCTCACTGTGCTTGTCTCTTTCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGGAAGCCGAAGACCATCACAGGGTTCCAGACACATACAACCCCAGTGTTGTTGGCCCACGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTAAACTGCAGCTGATGTATCAGCAGGCCATGCATCTGCTGTCAAGGGTGGACACGGCTGCAGACTTCTGGGGAATTGTTGCCTCCTGCTCTTTTGTTACTGAGTGAGATAAGGTTGTTCAATAAAGACCTTTATCCC 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@rCer/838/1576_58_CCS ATGGGGGGACCCAGCGGGTGGCCCACCGAACCGGCGACACAGCGACAGGCGTCAGGGCTCGGGAGCTGCGAGCCTGGCCTCGTCTTAGAGCTCGGCCGAGCCGCCGTCGACCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTCTGCGCTGTCTCTCCGATGGCGTCCGCCTCAGGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGACCCGCCCACAGACCTCAAATTCAAAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCGTCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATCATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGTGTATTTGAAATGCCTAATGAAAATGACAAATTGAATGACATGGAACCTAGCAAAACCGTTCCACTGAATGCATCTAAACAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACTGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTGTCAGAAGAAAATCGACACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGCCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTATTTCTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCACTGGTAGTACGGCCCGCGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTCACGGTTAGAAAACCCAATAAAAACAAACTGTTCGGCTCCTGGACAAATTGTATAGTACCAGATCATCACTAGCAGATGTCAGTTGCACATTCAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAAC + KKKKKKK+KKK:KKKKK8KKJKK.KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK0KKKKK:KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK;KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKAKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK:KKDKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKFJKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKHKKKKKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKJKKKKKKKKKKKKKKKKKKKKKKKKKKKJKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKJKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKHKKKHKIKKJKKKGKKKKKGKKGKKKKKKKKKKKKKKKKKJKKKIKKKKKKKKKKKKKJKKKKKKKKKK+KKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKIKKKKKGKKKKKKKKKKKJKKK=KK=KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKCKKKKKKKKKKKKKKKKKKCKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKJKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKJKKKKKKKFKKKKIKKKKKFKKJKKKKKKKKKKKKKKKKKKKKKKAKKKKKKK9KKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKJKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKK(JJ,K;AIKKID3=A:7GE;9A6A%KB;?6FA62D)H-H,'@G(KCKF;>KIKK%<@>>D#9:I7C?KID8I2KF4KH0KK:;KKDAD6%GBHJK-DKGD?KKIJHJKJJ*KJKJIKKJKJGJDK>JFA@HDKH0FH1G8K2&A=HHKBK@KIFKKK<%JAKIK=HKJJ@K9KI@J>IIF9J7IEJAF;$KF*IDKDFKE)K6%KJ;KGDC?CEJKKKKCGI=IDGIAIKKJEE?%*6FJI1KF?JKIJKKK>BCKIK0KI=E,.K33KCCB$6J@KFAJJKE4KHCKJIG1+JK-B'KKKKE91K-KK:K6K&KKKKJ%KIJI9KKK*KK,KKKJ/J6/GK>BFK?<=@A,KKJ:KK8KDJ5K=KJJ:KKI0KKKII:KJG:KK'KK/IGIKCK@KGICJJK5KK/KGEHCK@JK>>&KKK(KIB9H7KKKKKKKE4KKJ6K@F5KKKK&KJKJIC69I.K;>KK)?K18KDH92G.HKF1$JJC1KACFJA0EK/KKJIKG;J9IJKK=;KKKKKKKKJB8%K9J'IKIJ;KA2*FJJJJ=KI(J)71KJ9KHKK?DIEGJKK35&9%(*JD.8IJ=5HGCIG@?IKJ>K.0%KJFKG9J1IFB$JHKKKFAGI=KJKG4D<1KHHGH;KKG9<77>KHHKJJAHF$B=HHF/KKIKKIKJB@H;KF(K*KICJKKFK5JJ;K>87II3)G$GF>B8B=?FA.KKJKJJJ6JC>'DI.GG:GI7F=BE(JK,BJ9<.K@>?1KG@KJH3J=KKCH9JC4GI*6EKK>3KK'K/KJK@)H;480&JHEJEIK-KF:I4KJKKJK&KKH=4'K&7C@CFB8:=:;@;J=:J2KIJBHIKJB@JJH8HDKK=8DB/B?GHAGB@<5J=EA2ACEGF?CKEKIKCDIECIG>JJBKK0?GKDEK@KEJGEK'AJ;9DJK5;D=B*ADH62D.:JFKJ:K@KK2JIKKIF2IKE=J7KI@K5IFK=KJJJFIA%B+K>AJDJJK?FKABK:AK:K@EGHFJEIJIH>KJKKD?KK0IEG7JKJKDC,FCICBKJBJKIKGK@JK/-DKK9?EFI&AK7KCGJH)GKHJFJBIEJI@IK@J@JK8KJ3KB>CK=AKJKEHKG7;HKGKJKKIDJJGJKKJKFGIKIGKIKJKC,GCGKJHK7HD)HH-JJ8KHGHK-DIJFK>D?FJEK;KFKEKKKDDEHKBF5I'K@IK:F2%@KJ?KG&DB$HKHHIK:JGF;IBC.58IC6-DKC>JI5HJIKB;BEIEEIAHKGKJJK.F:GG8I?>?ECII5DKJ?E9G+=J1JJJKCKJ2HJH7IKKDJIJE9AHKK2HHKHF=GHC@9ICJHD=CED;@FG;I>G9GKJ1JDIKGJCKJJI-HJ4=G;@I@KGGG0GJ-KJ.GKBEK8E?K<9GIKHH'EKJKKEH=JEI>IGH<;KCIKGJJI)FIJGK7J6GJBAFFG>FC97JIIKGHGH@E@KIIJCKKKEGK=DGJDGKKFD@JD:JAIBKJGDFCK6KC=KGK6EKK>HIJJKCIKK1D.FFE5DDIJI:;/82&7+;4(840'==2187736-)$'73467&;61*67>:&$-+$$+0(.98,>;85:34/5272&078813$7;8.,1$#*$'2826+(**1)48.=81-,,2<>;35,:7.(:883588(9:7904%386%;5610,+6:6==-*0(>$;:2>0+2*5&;<:&++"(<75:*<(/38409,12?6/*&%<.=49:(+%/.+5<+,1?<8&+.=0:/A4=6.@?7+;09)(8.>%79:86:$>;224>'?:?&:&60?@<<;/:A@$?1CA9&79=6<(8>=(74;4?4='8,&64%285:<#4?@;=3'6?7;7%?;=44:<>6$)062,99=A5/0>:'>===<*8%$(9?>457;-@:;'A@7$&/&$/$83&85986,*:9A5.$,::??7$B0B)19),&?=2.D2-(,B;)>A9<=-8)5-6C6.?8/361'>;3891-=?:/-#$3'640D=5?:A>?94%=AB$>(2:B;.ABEC099$6C@,A7?);?A1;'6(A@?>@./3$:'$6;A5)?/10%.,24.D45(A<2B:E==3:444%0($0;==>634,9=.,45*<7+=<7'')>='428-?=';67>;8(6&2<>5+&'=;4=@:54#83@=A;<6=?7/42357<;/.0/*/*74#37:5+=;960&8)4(67125)"82.;;$"<*0 @rCer/844/2650_59_CCS ATGGGGACGCTGGGCAGCGCGCAGCGCCTGAGCCGCTGCAGGCCGCCGCGGCCGCCGCTGCCCACCCTTGCCTGTGCTGTTTCCAGCCTCGCTTCTCCGGCTTTCCTGCTCCTCTGCTGCCTTCGTTTCTGGTCTTCGGCCGTCCTCGCCGCCCGCCAGAGGAGTCCCCGCGCCCGCCAAGAGGAGTCCCCACGCCCTCCAAGAAGCCGCTCTCCGCTGGCCCGCAGCCGCCGCGACTTCGGCACAGTCTCTCCCTCTGGCTAGTCTCCCAAACGGCCGCTCCTCGCCCGCGGAAGACCAGGCTGCGACCGCGAACGCCCGATCCTCTCCAGGAGCCGCAGCGAGCGCCCGGCGGGCACGCCCCGCGACCACACCCCGGCTGCTTTCGACCCAGCGCGCCTGCCTTCGCCGCCCGCCCTCGCTCCTTGCCCGCTGCACGACGACGCGACAGCCCGGCTGCAAGCGGCAGACCCGACGGACCCGGACCCAGACGCAAGATGGCGACGGCCGCGTGACTTCCTCAGCGTCCCCGAGCTCAGCTCCAAGTGTACCTACGGACCGACTGGGGGGGCAGAGAAGGGCGAGATCAGGACTCTGTGTCTTTGTTAGTCGTGAATGCATGAAGCCTACCTCCCTTGGGCCTACTTGGTGGGAGTGTCTGGTATTGTTCTAAGGCCAGGAGTACGGTGATCCACAGTCTGTTGGTAGAAATTGGCGTCTTGATAGTTTGAGAAAATGGCGATGACACTGTTGGAAGACTGGTGCCGGGGGATGGATGTGAACTCCCAGAGAGCTCTGTTGGTCTGGGGCATCCCAGTGAACTGTGATGAGGCTGAAATCGAAGAGACCCTCCAGGCAGCGATGCCCCAGGTCCCCTACCGAATGCTTGGGAGAATGTTCTGGAGGGAAGAAAAATGCGAAAGCAGCCTTATTAGAGCTCACTGGCGCTGTCGATTACGCCGCGATCCCAGGGAGATGCCGGGCAAAGGAGGGGTCTGGAAAGTGTTGTTTAAGCCCCCAACTTCTGATGCTGAATTTTTAGAAAGATTGCACCTCTTCCTAGCTAGAGAGGGGTGGACCGTGCAAGATGTTGCCGTGTCCTTGGGTTTCAGAACCCTACTCCGACCCCGGGCCCAGAGATGCCAGCAGAGATGCTAAACTATATTTTGGATAATGTTATTCAGCCTCTTGTTGAGTCCATATGGTACAAGAGGCTGACACTTTTCTCGGGGAGGGACATCCCAGGGCCTGGAGAGGAAACCTTTGATCCCTGGCTGGAGCACACTAATGAGGTCCTAGAGGAGTGGCAGGTGTCCGATGTAGAAAAGAGGCGGCGGTTGATGGAGAGCCTTAGAGGCCCTGCCGCTGATGTCATTCGCATCCTCAAGTCCAACAACCCCGCGATAACCACTGCCGAATGCCTGAAGGCGCTTGAGCAGGTGTTTGGGAGCGTTGAGAGCTCTAGGGATGCCCAGATCAAATTTCTGAACACTTATCAGAACCCGGGAGAAAAATTGTCTGCTTATGTCATTCGTCTGGAGCCTCTGCTACAGAAGGTGGTAGAGAAGGGGGCCATTGATAAAGATAACGTGAACCAGGCCCGCCTAGAGCAGGTCATTGCTGGGGCCAACCACAGCGGGGCCATCCGAAGGCAGCTGTGGCTTACCGGGGCTGGGGAAGGGCCGGCCCCAAACCTCTTTCAGTTGCTGGTGCAGATCCGTGAGGAGGAAGCCAAGGAGGAGGAGGAGGAGGCTGAGGCCACCCTTCTGCAGTTAGGCCTGGAAGGGCACTTCTGAGTGCCAGAAAAGACAGCTTTAGTGCAGACCTAGATCACAGCTAGTTTTCTTGTCCCTGTGGGGGTCTTACAGATGTGTCTCTGAGTAGTAAAGGCTTAGCCCTGTTCCGTTTTGTTGTTTTTTTGGAGGGAAGGTTAGTCAGGCCTGAGTATTCATGTAACATTCTAAAATTGTGCAAGCGAGCACCGTGAGCTGCTACAATGCAAGTGGGTCTTGCTGGCTAAAGTGCCAGGTAAAGGGTTGGTTGGACACAGCGCTTAGGCACGCTGTCATCATGGACATCATAATCAGTTGTGAAAAACACACGAACCTCTGACACTTCCTATTCCACACTGAATGTGAAATTTGCATGTGCAGATGTTTACTACGGGGCCTGGCTCACAGGAAGTGTTCAGTAAAAGTATGAACTATTAGATTACTGATAGCGCAGATAGATTTTTCTTTACCATAAATAGTTCCAGATTTATATTGATGGAAGGAAATGTGCATTTATTAGCTATTACTCAACTTTACAATGCAAACATCATATTTCTCATCTTTAAACATGTCGATCAGTTTAATTGAAAAGTATTCTGAGACTGCAAAATGGGGTGTTAAAAAATACTGCAATTACGGAGCTGTGTAAACCAGTTTCTCATTGCATAAGATACAGATGTAAATTGCATGGAGAGGTTGATATGCACCTGTACAGTAATTCACTTCCCCATTTCAGATCTTTGTCAGAGAATAGTTCTTGTTCATACTGAGTGTTCTAAATTTGAAGTTATATATACAAATTAAAATATTTTTAAAAAT + 42655113,.+,0$42,$('-+13556/)*')+*+-),-10,,-,.*++0,2/12,11-+-2,10010/01,,1/011120/01.1/,-,++0++++)*&%/-(1-)*,02-.-$*0,02.0(1122*1010,-0,.2/00-,2.01-0,-0./--(*..2,,0-..-&-.,,/%*1/1-/1/.-,./22/,1110(&*#(%,.-.20*1/0*)(0012,-,(/(),,(..))(&.0/*/2/*10-0+/0//-+',,,2.-0/0-&*./+,2-/2.011/*2/110.100..%.//,001.../0..,+$/+-.$)-,.%-0001/0+0,10.,/2/1.+00'*),,-1,2/102-0/.()(*$..+-,,-+'/*.+,&+%*+0.()()-.)00.11100-1./0&)-1)*//)*/0,/-+),+&2,122/11*0/,*0,-/(&&%((,.*,-*.)+,.-+-,,-(+.-&+-,1.$//,//*00/+*&*.,+*0(*-,/0,1..0000'-)+-.*/2001.11.1100/-'1001/-,*+1.-/-110+-,(-110.-....*'+.//10)111112/-1+10010--,,)11000+/.012201211-*/10//&'00*)00'020,+01102120.-)00.,121210/.**/-0+*)-,-./,01).&,&0//&12-010'121..'.1%1//&0.01/00.110,-&2+2101001'/)),10/&000//.)/21/0-+)11100-.'1/0(&$+*0-*--*,0//%+*0/0-*).0'%+(-**-..-1/*0012/20110-0/*00.-.'111/0.01.&0101,0)+11.1-111.-010/./)02002110011/10111*12010/,&+,2010,*/0,011/1+.%--**%/0,).&*,''&///%101122/111-0)/'.0'),-.0.-)/0010-(-'+-.+1-)-+/+----./.$,2200.1*/0//0*-+.-0..222..011)01)0+*/%//0./+,,./-$+*.0*1011-1.'3303555)0445.323/+0&205554551/21455.00560,%5,.1044331.-.543*04$3454405+*/(45*3204110)0/3.6.54533&/6034/52125565524564166652555151.15653/3.0*5366656556610/4/3/03+300031,.3426446654161/1520%0454'5646664531.560&3/*)-0.3*/405466064,646424644614606656633664644-30.5.54120-/0,1245-5662/+*//23).02/212)046554*5535+12141(222304/4433064/356353.1625340.&30%,+30104-445,2144+)40)1(/15103.45443/+4446652665556464.10024355536/53/15354+565240364066/64554*01*/066456164566464503.5623.55040)/21324$55650/3451661-545-09871:24073280748383783858814,+*.3'0655.6213036420,))230.235626456361156/2556640411416343./41&5+5/0/32-)250.).,'+1116562420/10./)043152334'34455.0046/623562...-#./1*36.6435.0316564'/5456.54531//0,40041630.16266553546354014453.6/.463612.1344566104+5522414-4600)//-16666056662..5524545/55/122.+.-66324446224242544)06566664+304656*000*/0466643123241-46463366461541233654,63620221&1111232224+64222$115534-56655+334305455)(2/,.65356055134*50152/-'35156656264326466440../-31624324133521/01+52430/056430+-22265.5-2-4321,)4431/54424$2620462400010.45030/*40%0(562/)'-*(1.12'341+0./-0/3163542.4.2+14616546455154643*56433&566666335530334120012403*40565641-55.-1)./350002/355-1$36520141542.,2)02134+-/-0,35123526666.564//2)3//3+/111',-1-35645236266234/.53651566666654652542235-451*5*035*.15.1666562652+5546-,)-.4544*44'5666364200155515/+#&232*4/554256422136666544633-%/4+/4424%4531126565243/'56563/453-40.041),+',1)(2-,1$21*,0156450554536451/043-51//1/-(+3434560.+/313656.1*34..+0(344(1/444444(0242/445/4.54.*/%46504-434&1/*21-54,1135.0626334.5153*35535,121#,30/12%666634 @rCer/845/1792_57_CCS GGAGCCCCCTGATCAGAACCTTGCTTCCAATACCAATAACTCAGAAACCTCAGGTGCACCAGAAAACATTAAAGGATGCCATTGGATTAAAAAGAAAAACCCAAAACTTCATTTGTGTGCACTTACTGCAGTAAAGCTTTCAGGGACAGCTATCACTGAGGCGCCACGAATCCTGCCACACAGGATCAAGTTGGTGTCCCGGCCAAAGAAAACCCCCACCACGGTGGTTCCCCTTATTTCTACCATCGCTGGGGACAGCAGCCGAACTTCGTTGGTCTCGACCATTGCAGGCATCTTGTCAACAGTCACTACATCTTCTCGGGCACCAACCCAGTAGCAGTGCCAGCACCACAGCTATGCCGGTGACCCAATCTGTCAAGAAACCCAGTAAGCCTGTCAAGAAGAACCATGCTTGTGAGATGTGTGGGAGGCCTTCCGAGATGTGTACCATCTCAATCGGCACAAGCTCTCCCATTCAGATGAGAAGCCCTTCGAGTGTCCTATTTGTAATCAGCGCTTCAAGAGGAAGGACCGGATGACTTACCATGTGAGGTCTCATGAAGGAGCATCACCAAACCCTATACTTGCAGTGTTTGTGGGAAAGGCTTCTCAAGGCCTGACCACTTAAGCTGTCACGTAAAACATGTCATTCAACAGAAAGACCCTTCAAATGCCAAACATGCACTGCTGCCTTTGCCACCAAGACAGACTGCGGACACACATGGTGCGCCACGAAGGCAAGGTATCATGTAACATCTGTGGAAGCTCCTGAGTGCAGCATACATCACCAGCCACTTAAAGACTCATGGGCAGAGCCAAAGTATCAACTGTAATACATGTAAACAAGGCATCAGTAAAACATGCATGAGTGAAGACCAGTAACCAAAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAACAACAACAACAACAACAACAACATGTGACAAGCTGCCAGGAAAGCAGGTAGAAACACTGAGACTGTGGGAAGAAGCTGTTAAAGCAAGGAAGAAAGAAGCTGCTAACCTGTGCCAAACCTCGACGGCTGCTACGACACCTGTGACTCTCATACTCCATTCAATATAACATCCTCTGTGTCGTCTGGAACTATGTCAAACCAGTCACAGTGGCAGCTGCAATGAGCATGAGAAGTCCAGTAAATGTTTCAAGTGCAGTTAACATAACCAGCCCAATGAACATAGGGCATCTGTAACTATAACCAGTCCATATCCATGACCTCTCCTTTACACTCACACCCCAGTCAACCTCCCACTCCCGTCACTGCCCCAGTGAATATAGCACACCCTGTCACCATCACATCTCCAATGAATCTGCCCACGCCTATGACATTAGCTGCCCTCTCAATATAGCAATGAGACTGTAGAGAGCATGCCTTTCTTGCCCCAAGCTTTGCCTACATCACCGCCTTGGTAAACAGTATTATAAAATCAAAATATGGGTTAAAGTAAATATTTACCAGCAACTTAACTTTTAGTTGATTAAAGCAAAAGTAAACCATGAAATTGGGAGATTTTGTTATATTAGTTAATAAGAGTGTGGTAGCATTTTCCTCCAATTTGGCTGGATTATTCAAAGTAGGGTGTGTATGTAACTTATCACTGGACCACTTTAGTTTATCAGAAATTCCTTTTAGCTGACAACATTGCTTAAACAGGATAGTAGTTGGCAAGATGAAATGCCAGAATTAAAACCAATCATAAATAAGTAGAACCACT + /$-.3314)(021536/+7%*&2-7,,,:55:28:6243;+40,8=,-'7;58%8*-*4,4*5<8,959'88/<95317/0.%<+72.:=9;/379;9)85*8;9'3403.04%)*0/+/0,2&.,-3;3810056;;=046;=)476326+5=;$-94;,95=7177807,/27:244,,,<$/:4=38<%=277076-3(>/;=-:997&;4<;.585/2=786/@44>?%@)7A81<44749/4580:98&9A;7>B;B::?9@B08383;*=63>B@48:<76><=$27.;A>B@C<>65:1<77?<46,::C?28BAC58:58=8?47=2=78>ABB-?(;5-8;9A50=>+9<-.8;7.3>3>B?><+-<=?A<<088%;>)<1@>94910;&00;3'.*=63:;/><@?6=A7;7A,B9;%99+>46;09;;.78/797667<.;*7;=B2A1<56$;9:A?6,@D0BD97>??8?-5.89>)39378136>>><7BE=5E6=A=/;EB@DD/EFF:FB+4=757B5EG5A;(2;1:+).85-99;C>>07<9::7=9F:BD>>@6>>.@70+;C/>4:&7DC==C@1DB=A4BD482A/AAA8@G2BC84CEEEF)>@7C>D0AF5:?5>EG4;A;7=19EA>;:8AB2AF51:=21<:==6%85,13>B17G<@4<<,A8;<@4>>3;@9486>?2;?(D3,C)5D68B+@D6;EB6<3C3AED5AGF@<8<;?C0:'@0:@?8AA0C+EA??@G:@EB9?E<=/66C59-6*3730@>&2><:@26@@AB0<9>*<$3:138<66BC<@@:?88?:44?:*0618:A@=?<=.<017<,@;>;:@<&07;?<,>1?3.<;@7<857>?*?.;0C0(3/;=?(75:/AB>=79/(9A5(66@:?<5>.6:,@;1%0;4:56&096;+;(81B07/27@-A=<>C/78A@8-3:@@+7-26>++.,91,:8<>=&73959A07232*<4+-92;1=>?;=;<666$1+5;(6719433?<8194:;9'5551:6:9:/;8?/8;990$,'2698189=<;<>0??0*=.6947&8+/<=;)5:)972682;6&;=4>,;/8;=3:6*55,'2/:;;(3:=;<3;81=7'9(8>3=9:;4=;??41=18.<:,6;0<9=<:8*69<999=5;<*80047#24:7->:=68:8'-%><08;6>=:)7=859;:248=6=9;0:74&:&7>1:/<<.96;7;-:<34<0489'362;:027:986/::>,/=>9;=8267,2619<>>777;:+&/>9;=>2>0=0886(8785>=8=29:>0:4=0::&9=>3::8>>7,?:9,=?5:780?>1>89129<+:/:::'?7>2=83486.75+5:54819%22? @rCer/847/25_813_CCS ATGGGGTTCACGGCCTCGGGATCGCACCGGGTCCTCTGTCAGTAGCTCAAGCCTCTCGCCTGCGCCCCACTCTCCGTGTCCCGCGTCCTAGCCGACAATGGCAGGGCCTCTGCGCGCCCCGCTGCTCCTGCTGGCCATCCTGGCCGTGGCTCTGGCAGTGAGCCCCGCGGCCGGAGCGAGTCCCGGGAAGCCGCCGCGCCTAGTGGGCGGCCCCATGGACGCCAGCGTGGAGGAGGAGGGTGTGCGGCGTGCCCTGGACTTTGCCGTCAGCGAGTACAACAAAGCCAGCAACGACATGTACCACAGCCGCGCGCTGCAGGTGGTGCGCGCCCGCAAGCAGATCGTAGCTGGGGTGAACTACTTCTTGGACGTGGAGTTGGGCCGAACCACATGTACCAAGACCCAGCCCAACTTGGACAACTGCCCCTTCCATGAACAGCCACATCTGAAGAGGAAAGCATTCTGCTCTTTCCAGATCTACACTGTGCCTTGGCAGGGCACAATGACCTTGTCGAAATCCACCTGTCAGGATGCCTAGGAGTCTGTACCAGGCTGGCCTGTGCCTATCACCTCTTATGCACACCTCCCACCCCCTGTATTCCCACCCCTGGACTGGTGGCCCCCGTCCTCGGGAAGGTCTCCCATGTGCCTGCGCCAGGAGACAGAAAACGCAGCAGGCGGCCTTTGTTACTCAGCAGGGGCTCCACCCTCCCTCCTTCCTTCTTGCTTCTCACAGCCCCGGTGTGCGGTGACACGCCCCCACCTCCTGCAATAAAACAGTAGCATCG + @<2C==:>>9==B@E;????CF=I>?8H<>B:3FB=@ID;CJDJ@GJF3IJDG;=CIJAJGEHG8JIDGG>DECD=BEA0CKHEC@CIGGC@HGAA7JE6HJC8DICJIG>IJJGD.=CCHBGHGGBIGJF:0IHJCA9F>,H>JHJ?JJ@>1DJJFB?CBH>GGHGI<@>KAE@CHG(:99EK9GBCIHBGH=IGJE@HGHE=9EH==EE@B9==<,@C@J<'63?FC@E=>8B@ID,D:E6AIIF8CBDCIEGG<4?F>FF;@F3EHBGEDJD?9D49@?CDHJF5HJIJ8KHF?DFJIEDCDA<%<73BE1J8CC.5BCEK@IBHJB8J>I?K:FH?IE6J?GD@D@DAB>CBKB9:HH@;7EF9D@;IAH;F@JGAH3JFE:A=;AB<=JG>J?KC@DGCBH9ICH/>6IIK@79EHIDG;EDII=D@FDDEI8B==>KF.;AED>IGICHF>IKEKBJB;>$FH@II;GDHGJIJ4HEEIJDIIIA)IKIBGIBJJ>=BC(D6C0>DA,ACG=IEDJI$JGEC>5<<:IHE6KKB=ICJ:IEKJHKJH@J8FD:IDD8IDG?GEE6CC%9AECF>EH&FGHCB6?E6JCIK@H=*C>;<<:@72$63>7-;7>6;91?A>.=>2=:?4?<=@@5$<-593%6+98:6/81@<4'=.%1;?6:>:1*:6<9<961037<*BA6:2?5<=:61=;78@>0508)<;38868C<3??/*:;=9<=?<43;>4;82C2%;0336)010436.7-%.8>30=7*442;2>+;6?52696$==$5=B438>;6=85<;&8==C?(=/*99>8,.@4*;>'78)-$54=;>(82?@4.$310=<477/1;43&,48<.460/>.53:,;A7?85059<<>2<01808:<>=16:?062A;,76,1>@>=2799/51%,;*9'7?978?=?A>=>4?+$79/';;7C2CB=@99/7==85?<87--@&09;;%?9/78(4@;36AC?>1?3>B>B0?=>@@;??5;5:9?<8A4(59;<4;8;83;64?94;9><$<2+8==;;?7=6>?<95A6>)26;9:.=A=>=?@;A?7?3<-8$2+1'..):96<=2<;:<8=8;&A/<;5=71:'*4:?AA12==;69>BA>+A*=<5:;AB92/@A62C?<7&:96:?);=)9?C?;2*64.;?;A9D:&CC@>ACB;A@8628B;>>@5.)7=1:89.>&?B:7B%;;:B092:=(=;>AA4=+7:%96$64C>9;8A<;5.:'>9@.@=I=EI;C%?@$?F2:ICF0FA*BAD&E=?DAAB&??3=6CD@A;B'@8I/AADDD@7DIGFF>CCA1>:BA@5>A/7;;EAB;CG=A*<?99B9CD&?+A?E7FGG1@B+FBBHBGGC>(8<>;<25F@,A9D@=AG@(=G>;>B8E>EBDFG6@F8F;3?A9<@F:?C7?5EED5HE>>:>8@<=<)A=95$&@DE?E>5:E>A:HF7$49?1BBHHD>(GBJGC@DIEJCD3FEH-G73A?G4F+@?+/C?/HFG<+@>C-DDDB1=C4:;E%AB>B=H;F;:51-6.3=<9%9>H3FHBG==E8E>BCA@;CH9=;-;B4@EG2GH&@B5IIH6=9HDJFECB88.KBJ@JI0G0HDGEBFCAGK?:KFCDJDIJG@JAH3F.CGAJJD=E5FEGHIKDAJEGBI9AF(DEJ8FEECH8HH39K<-HJGEI6KH&:BFJEKK+DCDGIJE@'F@A@DHBD@>KI,@:A=GA+HEAGFBBC?B;?@HC>E3KE6A)<=AIHC8HEK2G5BI;7I9IKJJKHKH:6*J13=9A6=D/&79JF0D4@:C@7B.ABFD>D:>GC3;E4E$3.D==C8E?EFCB0;>E5DFC.91,EC(G16E @rCer/849/1466_57_CCS ATGGGGACGCACTGCGGGACCTGGTGATGTCCTGGGTTGGGGCTGAGGAAGGCCTGTGTGCGGAGGGTGCGGCCTTCGGCTAAGGCAGAGGACCGGGGTTGGGTCCGTGGCGGCGGGAGGGGTGGCCTCCTGCACTGGGCGCCCCAGGGGACCTGAGCGCGACAAACAGTCGGCGCGTTGGTACTCGCGCCCGCAGAGCTTTCAACCTCCGCGCCGGCTGCGCCTGTTTCTCTGCGAGGGAAGCAAGGCCACGCGGCCTACGTAGCCGAGTCGGAACCAACCGGTTGTTTGGTGAAACCTACCCCAGAGCCTCCCACGGCCCACAGCGCGCAGACTGTTTTTGCCAACCATGGCATCTGGAGATGACAGTCCTATCTTTGAAGATGATGAAAGCCCTCCTTACAGTCTAGAAAAAATGACAGACCTCGTAGCTGTCTGGGATGTTGCTTTAAGTGACGGAGTCCACAAGATTGAATTTGAACATGGGACTACATCAGGCAAACGAGTAGTATATGTAGATGGAAAGGAAGAGATAAGGAAAGATTGGATGTTCAAATTAGTGGGCAGAGAAACATTCTGTGTTGGAGCTGCGAAGACAAAAGCGACCATAAATATAGATGCTATCAGTGGTTTTGCTTATGAATATACTCTGGAAATTAATGGGAAGAGTCTTAAGAAGTATATGGAGAACAGATCAAAAACCACCAATACTTGGGTATTACACATGGATGGTGAGAACTTTAGAATTGTTTTGGAAAAAGACACTATGGACGTATGGTGCAATGGTAAAAAACTGGAGACAGCATCTTTTTTTCAAGGCTCAATATTAAAAATGGGGACAGGAACACACTGCACCCAAGGACGTGCTTGTGGTATTCAGCACACCTCCCATAAGGAGCCACTGGCCACATCCTTCCCAGAGCTGGGAAAAGGCTTCTCTCCCTGAGGCGTCCTGTGCCTTCTTCGGCTTGGGTGAGTTTGTAGATGATGGGACTGAAACTCACTTCAGTCTCGGGAACCACGACTGTTACATAAAGGCTGTCAGTAGTGGGAAGCGGAAAGAAGGGATTATTCATACTCTCATTGTGGATAATAGAGAAATCCCAGAGATTGCAAGTTAATGAATCTTAATCTTAAGAAGTAAAGATCAGGACTTTTTAATTACTGTGGTAATTAAATTGTTCAGTATGTACTTATCAGTACATTTAGTCTGCAATGTTTTTATTTTTTAAAAAGTTACATGAAACTGTAACATTCCAAGGGTCAGGAAAAAAACCAATTATGTATAGTCATAAAAATTACAATGTATGATGCAAATAATGTAAAATGTTTTAAAGACAAATGGAAAATAAGATATGGACCAAAGTCACTAATGTTTTACAACAGTAACCTTTACTATAATAAATACT + HKKKKGKKKKKKKJKKKIEH1JKJGKKIK?J;KDK8K@AJK%JKHHKHKHK;K6KKKKJJKK;GJK'KJKJ2IBJHKKGKKKEJEKKJBKKHI@KKK@KKKJKJHJJJKIJ@0GEKKK6JKKK8KKK4IC$JKJKKKGK2HKKKKJHJKKCKJKJKHKJIKKKJKCKKKKKKKKK?JKKJEKK?JKKKKKKKKKKKKKKKKK;GHKKKKKJKKCKAKJKKKEK=IJKKKIK;JGKKKH7KIKKKKKKIKGKDKJKKKJKGKKKAI;KKKKJKEIIJKG)FGCFHKKK=KE2=KIKKGKKIKKKKJJIKKJ%HG,J:KGH.K@HH>D>KCKJKKKKKKJJKGKJKKKK@KKKJKBFKJIKKGJFHAKKIKBGJJKKK?EJKKKKKCKKHKKKKKEHKKKKIJKKKKKKHHAKKK>JKJKDJHKJHKDKCIKKKHKKJ7JJKEKK@KJ?JF>EFHIKG=HJJHBDGKKKKKKHKGCHKKJKKJ8KKDKKKJK@BJKKJKKK/KHHDKKK'KKJKJKJ4DIKHI>GJFKIICJKJKHDJKFKKKJKKAJKKEKKIIKK@KIGJIKJJIHKIJKHCKHGKKKKFKJKKKK5JKHJJKJKKKGEIE?=F5EHKK@IJJJKKKKG;IKKKKKJHHKJJDFHKKKKK2KK?K@JIJJBKKK2?KIJ2JKKK?KKFIJJ@HKKKKKKKJKK0KIKJKKKKKKK@CIJ2JKG;IEKIIKJKEKKIDFBCFKKJJKGFKBJ&JDKHHEKEKIKK0JJKKKKJI%KKK1KHKKKKHGHKK9JKKK?KKIK?IJJIK5KKKJDK8JKKKKKDKHJIKGKCHKK4KK>JKKJEKKKKKAKHJJKDJJJ6K9KFCJKICCKKJKHK,KKHKKGB@KFIKF@>EKIJCKGHJKIKKKKKKK5KKK=JKKKKKHKKKGKKKKK@JI:JKI5KJKKKDKJKK;GJKKKKJJKKK;KJKKJK6KIKBIKHKIKHKKIJGKK9KKIKEJKHCAHKKHKKBJIH@KKJKBKKJKKKKKKJHHJIKKKK?EKKKKKCK?JJKKKKKEJKKKKJKHKCKJJFJI(>FKFJIKKKGE-JAKDJ%HJJD?>@JAH@JKKKJ6IGEKKHKKJH9KJFJKKI>KKDGIKIKJIKJKKJ@KKJJJHKJGJKDKKK6JCDJCKKJKHHKKKK=IKIKKKKAJ=KKE)JJKJKKKKK8KKKJGJIKEJJHDKKGKJKK @rCer/851/25_1858_CCS ATGGGGATGGCAAGAGAGACAGCGATGGAACTGCAGGATGCAAAGATGAATGGAGCCCTCCTTCGGATGCTGTGGACTACAGGCAGGAACGTGAGGGCTTCCTGCCCAGTCGTGGTCCTGCTCCTGGGAGCAAGCCGGTCCAGTTCATGGATTTCGAGGGGAAGACATCATTTGGAATGTCAGTGTTCAACCTCAGCAATGCCATCATGGGCAGCGGCATCCTGGGGCTGGCCTATGCCATGGCCCACACAGGAGTCATCTTCTTCCTGGCCCTGTTGCTGTGCATTGCGCTTCTGTCGTCCTACTCCATCCACCTCCTGCTGACCTGTGCTGGTATTGTAGGCATCCGAGCCTAATGAGCAGCTGGGACAGAGGGCATTCGGGCCTGCGGGGAAGGTAGTGGTGGCCGCAGTCATCTGTCTGCACAATGTTGGGGCCATGTCCAGTTACCTGTTCATCATCAAATCTGAGCTCCCCCTGGTTATCGGCACCTTCCTGTACATGGACCCCGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTCATCATCATCGTCAGTGTGTTAATCATCCTGCCCCTGGCCCTCATGAAACACTTGGGCTACCTGGGGTACACCAGTGGTCTCTCACTGACCTGCATGCTGTTTTTCCTGGTTTCGGTCATCTACAAGAAGTTCCAGCTTGGCTGTGCTATAGGCCGCAATGAAACAGCAATGGAGAGTGAAGCTCCCGTGGGACTCCACAACCAAGGGCTCAATAGCAGCTGTGAGGCCCAGATGTTCACAGTTGACTCACAGATGTCCTACACAGTGCCCATTATGGCTTTTGCTTTTGTCTGCCACCCTGAGGTGCTGCCCATCTATACGGAGCTCTGCCGGCCCTCCAAGCTCAGGATGCAGGCCGTGGCCAACGTGTCCATTGGGGCCATGTTCTGCATGTATGGGCTCACGGCGACCTTTGGATACCTCACCTTCTACAGCAACGTGGAGGCAGAGATGCTGCACATGTACAGCCAGAAGGACCCTCTCATCCTCTGTGTGCGCCTGGCCGTGCTGCTCGCGGTGACCCTCACTGTGCCAGTCGTGCTGTTCCCGATCCGCCGGGCCCTGCAGCAGCTGCTTTTCCCAGGCAAGGCCTTCAGCTGGCCGCGACATGTGGCCATAGCTCTGATCCTGCTTGTTTTGGTCAATGTCCTTGTCATCTGTGTGCCAACCATCCAGGATATCTTTGGAGTTATCGGGTCCACCTCAGCCCCCAGCCTCATCTTCATCCTCCCCAGCATCTTCTACCTCCGCATTGTACCCTCTGAGGTGGAGCCTTTCTTATCCTGGCCCAAGATCCAGGCCCTGTGCTTTGGAGTCCTGGGAGTCCTCTTCATGGCCGTCAGTCTAGGCTTTATGTTTGCCAACTGGGCCACAGGCCAGAGCCGCCTGTCTGGACACTGATCAGGCCCTGCTGGCCCAGGTCCCTGTGCGAATGCACATGGAGGGGTCGGGGCCGCTCCCTAGGGTCCCTCCTGCCCAGCATGTGGAGGCGGCTGGTTCCCATGAACGTGGTTGTCAGAGGCGGGGGACAGCAGAGGCTGCAGACTGGCCCACTTCCCTCCTCCCCAGGGATGCCAAACTTGGATCATGGCCCTAATCCCATCCCCAACCCCATGGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGAAGGAGGAGAAGGTGGCGGAGGAGGAGGAGGGCAGGTCCTGGCGGAGCCTTTGCCCAGCCCAGTCCTCTCTGCCTCCTCCTGGCTGAAGCTGTTTGTCAGGATTACCCTCGGGCTAAAGAGGAAAAATAAAGATGTTGAGCTAC + 84/6:=<04<95;<:66=>>>>=:8;:?7;5736;;?>>6;<5?:??8+99:77-2=88$;29>2=;?==<>8;?8877682928:?;?<58754:?>7:7>:==??:/587::==8<7?;=5<6;9>9=75<=25/8338644::6=2984=.48385/::;9>79=18<389/;74989>>:?6;2=149;:161)2.8394657<:5?;?=7==>=5;=>8=>:6?6<;=<=1:;79<>5=8;=?>;?>=<>?==?>>2:7:?>4548.<7;;75:67318=64:4361+;88:7=6><=?9<5:36;?;>5<<>8;697989;=8=>=>$&2704:75*7-;76<>><,<=85;88593=2:9347:>/;;:5973:;?8899;?>798<28:9:99>9:8/08;798;9>?>;?>>4?;8=>>8=>>980;=/>9>>:=<=;='<<;797;459<>88=97:.:8878/68;=9>46;:8:<6;99=;:6=9;==<9:8>298-98<<75=>7%6>?>>92292,2118;<>4263)5792963>;;??>;;'98=>8:48798:;<168552.42)<<>>::8768=7=?=:>=99986&133:693,72<978:998=>6<7-:034;;:636:=;8==><9:8/=;1(3777>:5;14399;=69::1*96<:::9172296==><9:?<2;5>=37>5:<;1=7)624>246037<45<>>8?/<7<:>8;08:>:>>9<2;99:6994=4==:?7778544631:;6%'6=>>4:9;=49>>5:>74<87:9=<=>;98>9989<<38:?17918?;?<<>===?8.7576977=:2<;>,853::=2=<45.<>=7=99=58>>63:><:6<5;?;>739BAB9?=@?B?<@4>A=AAC=+9:5;;:@AC>>=;=B;&@>1=BB?@<>AA<8>8?>7?>:7?CCA:=>BA;8:?8??=:5755>8197?=;?3A@:87:<7<978<74>;C9B3573=6>5@9;?;;=?>5?A67419<8AA7&?>=7B<=9=;67;A@=A>9;AC:8:@<>?B@A=>?:5?>/6389;83=1<995;48:97448?7=?>>4;790535;85:9?:3;6/76;71:4976<;66=?>423694=;?:8:;=35<85=8;22%17;9=:88;26:8?;;>3569?8=?9;?9:><=08978499<;;6:>=>;9=885=5&47;9/;>?;8=::99$<:7:>8>7872797;847:;;886./786?9:6082::;15238-3.+4:8.95027:=;8;+7;<98>:>==7777699/55657)78505+=:;8;;)8:9;502783-9340755.9996=9<>;:=<79:779:<=:?.:3,2539>><:>5,2;9<=>234*6797:85>>4>:5>9==<0530:;88<85;8=6=:98=;.9?;3-;;76=:=7>:99?>???=-72<39?95:7>??9413;239%;961>28=,5>647997<7967<;5=;8819<<7><66:18<;<7=;88>85/88=<:?:,49:61;86<88;=::=>7=/;>:4::;67=<:86/=<:<9<<:?=7:5;:>:<:;>4?67>=2<=792436607719<6<78;<60<<=>1:7;=:=818=::: @rCer/852/2184_59_CCS ATGGGCTCGGGCTCGAGACAGAGGCGGCGTTTAAAGCTGAGCGACCCAGTACCACTGGGACGGCCAGCTTTTCCACTCAGGCTCCTCCAGCCTGAGCCAGAAGACCCCCTCCCCCAGAATTCTGGGGGCCTATGGAAGGGAGCCGAGTCGGATCGCGAGGTACCCAGAGCCGACAAACCCGAGCCACAGAGTGTTGCCAGAAGCCCCGCCCCTAGGAGTGATCGGAAAGCCTCACCCATCCGGTGAGGAACCTGGAGGGACCGCCTCAGGGCGGAGCCCGCCGACCATGGCTACGCCCCCGGGGGCCGGTCCTGCAGCTCTACGCTTCGCCGCCGCAGCTAGCTGGCAGGTTTGTGCGCGGACGCTGTGTGGAACATTTTCCCCGAGTACTGGAGTTTTCTGCGATCTCTGCGCGCTGTTGCCCCTGGCTTGGTTCGCTACCGGCACCACGAACGCCTTTGTATGGGCCTAAAGGCCAAGGTGGTGGTGGAGCTGATCCTGCAGGGCCGGCTTTGGGCCCAAGTCCTGAAAACCCTGAATCACCACTTTCCAGAATCTGGACCTATAGTGCGGGATCCCAAGGCTACAAAGCAGGATCTGAGGAAGATTTTGGAGGCACAGGAGACTTTTTACCAACAGGTGAAGCAGCTGTCAGAGGCTCCTGTGGATTTGGCCTCGAAGCTGCAGGAACTTGAACAAGAATATGGGGAACCCTTTCTGGCTGCCATGGAAAAGCTGCTTTTTGAGTACTTGTGTCAGCTGGAGAAAGCACTGCCTACACCGCAGGCACAGCAGCTTCAGGATGTGCTGAGTTGGATGCAGCCTGGAGTCTCTATCACCTCTTCTCTTGCCTGGAGACAATATGGTGTGGACATGGGGTGGCCACTTCCAGAGTGCTCTGTTACTGACTCAGTGAACCTGGCTGAGCTCATGGAACAGAATCCTCCTCAGCAACAAAGACTAGCACTCCACAATCCTCTGCCAAAAGCCAAGCCTGGCCCATGTCTTCCTCAGGGATCATCTTCAAGGACGCACCCAGAACCTCTAGCTGGCCGCCACTTCAATCTGGCCCCTTTAGGCCGACGAAGAGTCCAGTCCCAATGGGCGTCCACTAGGGGAGGCCATAAGGAGCGCCCCACAGTCATGCTGTTTCCCTTTAGGAATCTGGGCTCACCAACCCAGGTCATATCTAAGCCTGAGAGCAAGGAAGAACATGCGATATACACAGCAGACCTAGCCGTGGGCACAAGAGCAGCCTCTACTGGGAAGTCTAAGAGTCCATGCCAGACCCTGGGGGGAAGGGCTCTGAAGGAGAACCCAGTTGACTTGCCTGCCACAGAGCAAAAGGAGTGAGTGGAACAGAGTTGCTTCTCTTTACTAGGAGCACATTCTTTGCCTGCCTTCCCTTCATCCTATCCTCTGCTTGCTCTCACCTCAGGAATTGCTTGGATTGCTACATGGACCCCCTGAGACTATCATTATTACCTCCTAGGGGCCAGGAAGCCAGGTAGGTAGTCTGAGTCAGGATTGGATTAACAGCCTCCTCTCTTGGAGACTCTCAAGAGCCTGTGTTCATCTAGAAGTAGTAGTTTGATTCTGGTTTCCCTCCTACAGTGTGTCCTCCATCTCTGTGCAGCTCCATCATTACCATAGGGGACTTGGTTTTAGACTCTGATGAGGAAGAAAATGGCCAGGGGGAAGGAAAGGTGAGTAGGAAGAAGCAGAAAGCTGGGGAAGGCGGATGGGTAGAACAAGACTGAGAAATCTACATGCTTCAGAATTCGGAGGGCTCAGGGAATGGTTTCAGATGGTAGGATCTCCCTGCTCCCTTCTGTACAGGAATCTCTGGAAAACTATCAGAAGACAAAGTTTGACACCTTGATCCCCACTTTCTGTGAATACCTACCCTCTTCTGGCCACGGTGCCATGCCTGTTCCTTCCTATGACTGTAGAGACAGCTCTAGACCCCTGTGATAGAACTAAAATGCCCTTTGTACTCTGCCTGTCTCCTGCCTCTTCAGCTCTGCAAGTAGTTTAGTAGGAATGGAGTGGAAGTCCAGGCTTGGATTGCCTGACTACACTGCTAAAAATATTTGTAATGCTTAATAATTAAACTTTGGATTTG + 9@GG<7>?EE:475?9=9;;>?-3;645<7675827957022,*583890046599:5/5:;793259888):55958475-+:85;985998::9;592:48:7988/42410)326.93899:9607*6833'7/:;2:87,58743936595:758-6885::7555055313'38.34482558:7),25-595::638999(1;99056;84:9:8/66.98)8;797.:;5332)8$&31:68%:7,439:866:+9814:9:9.99023:894:1:872/6522-4212437-679:,:2944;2/8784999428.77.8553-5.4:9442:76:;3939696,7276:89-89:9585::;08-36989-366&1692859:5:3584(5877765.8755::::::9937;9:37;9495978(67::8;9;792:65:9916:;:;:55.3:;659/8;96:9;994;::;::;:56)85::7.9;::749988:3:9::9.89))3%-)52:*84885.9;59:93972:7359:/54+854728:-9;7967378:4:;5869;65092567:;;699.4294957-3*4157766'9999+9:96:6868:5698)+77937:9679<.==>;>;=3',0653;'45=<3?<9<=3?>96;9<;>:>;9=:?;6:9=6>?;??:9>;=95<<:.;7240;9-78<964>>7=163:6;&:86:9=875125>=69>><>9;6>>879:9471==6:6+&2821-<<1:08,57.898:<3<4<8><>=587>>=?;:/=?;<99=9><7=9<5699:>=2<:>;?<>><;29;>98<==>:8=9>>7839;9=697=;8<4;?=?:?96?=;893149>7>=6=5=;8:*/86;7;1<=?;=6;;<)88:88;<4479649748=;979>=9<<8+8:6=:=:96:,87)5:<:7;<=>=>:??>=7=548843;7:;7>>>;9?>;9=;?:*<=3<8*-9=>9;=91?96::.9-5>39>;93*7:<=78>=3>8;;>6;8/==>9<>?=989:3>19>=<;8689;>?;9:=>>=>858;==5=6;;6<;,5;1>8<=2=;4=38497>:55&9<;6==75>;?<99=71=;5><99763<86>=85/==6:66:-9:90;>983:8982;2667;7;25:451>?>?>>?978=3405/9:/2<>9>?>;?:;46<9?9876<<<:&>6==6=>:=3>792<7;>??>><=1>?:<1=?79>74>>=<=;.?=>=:;>95>4:0>?>?=?>?<6.=>==8/9>:8?;:>;6;9>3=??;;>798><<)=>/?57:169>797)8;=><<1;4=7=7:9:;05>:6,<-=;;;;:>?;=>9/=5<>3:;4<<265=7;=1.>?>=92:39716>:8=;56%?8<70?<6;7>?>39?8;:>9.8<:<:><<78>9?7:<4?:9;967:29;89>8:?;=:>>633;75680:96:80=0;<2<;3734:7>?;:>56:;39/4;/8;43>>;=:;.7=<757=;689::147036/5>:149:5;69=9>>><:<99:>?58<3?<;===4/=1?<=>:?;8=:<:>>=>75<:<=8/=6888;39=9952<;?:>?:;9<7;><=?:>>;51/<8>;>?=<>:7-=?7=>=7<3=>><4=6;:99?1<2;=;?<>>?=:468<<1=<<>;:9=;?>;==9<;<<:=88=>;8>=<3<<>>:3:88>><>>28:;39857916,<9=>>=8<68;+1=<9=?39==;7>?<547<3<=>:7<<1=<=4?>976<=>7==8>>;9;:>=>>::;;<>>6>>9<=4=??9?>:=;9>>>8088*<6/>96958,;=88<7<:06<>::984:;>8==:=;<+-4<:?:;97?79=:39<0><=2?:43.8);7;9<795.79=9:=9;79:'9:??=<:?;374?:<><;6;-8?5==;:;2*<>.= @rCer/853/1900_63_CCS ATGGGGACCCTGTCGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAACAACACCGAGAGCATCCTAATGTCCTATGATCATGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACCGTCTACCTTACCCCTTACCGGGTCATCTTTCTGTCCAAGGGCAAGGATGCCATGCAGTCCTTCATGATGCCGTTTTATCTCATGAAAGACTGTGAGATCAAGCAGCCCGTATTTGGTGCAAACTACATCAAGGGAACAGTGAAGGCGGAAGCGGGAGGTGGCTGGGAAGGCTCTGCTTCCTACAAGTTGACTTTCACGGCAGGGGGCGCCATTGAGTTTGGACAGCGGATGCTCCAGGTGGCATCTCAAGCCTCCAGAGGTGAAGCCCCCAATGGAGCCTATGGCTACTCTTACATGCCCAGCGGGGCCTATGTCTATCCCCCGCCAGTCGCCAATGGAATGTACCCCTGCCCTCCTGGCTACCCCTATCCACCGCCCCCGCCTGAGTTCTATCCAGGACCCCCCATGATGGACGGGGCCATGGGATACGTGCAGCCCCCACCACCGCCCTATCCTGGGCCCATGGAACCTCCGGTCAGCGGCCCCGATGTCCCCTCCACTCCTGCAGCCGAAGCCAAGGCCGCAGAAGCAGCCGCCAGCGCCTACTACAACCCAGGCAACCCTCACAACGTCTACATGCCCACGAGCCAGCCGCCACCACCTCCCTACTACCCACCGGAAGATAAGAAGACCCAGTAGGCCCTCCTGCCTCCCTGCCTCCCACCCTTATCTCTGTACCCTACCCCTCCCATTGGGGCTGCACTGGGGCTTGGGAGGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGGGACATTAGGGCCCCCGGCCTCAGGAGAGGTGCCGCCCAGCTTCCATGCCAGCCCAGAGCCCACAACGCTGCCCAGTGTGCCTCACTCACTGTCTGGGGCTCTCCTGGGAGCACGGGGCATCCCCTGTTCCTGTTTCACTCTCAGCTTCTCCCCTCGAAGGGACTCTCTGGCCACCTCCTCCACCGCAGTCCAGCTCCCTCAGTCTGGCAGCCACTGCTACACTCAGCCTCATGAGCCACTTCAGACCAGCCAGGTGTCTTCCCCGGCCCTGCCAGGCCCTGCTCACATTCCCTCCGCTGGTCTATGCTGGTCTCAGAAGGCCACCGTGTCTGCATTCCACTCAGCCAGGGTCCAGCTGCAGCCCTGCCACTGTCCTTCCCTTCCTTGTCCTGAGTCATGCTGTTGCCACCCCGTGTGACTTTTGAAGCTGTAAAATGAGCTTCCAGGGCTTGGGTGGCGTCTGGGCAGGGCCGCCGAGGCTGGGAGGAAGTGCTTCTGCCTTTCGCTGGTGTTTCTGGAATTTGCTTTCCCTCACCTCTCACTTCCCTCTAGAAGGAGCTTCCTGACTGGAACCAGAGAATGCATGTCTGTCCACTTTTGGGCTGCTGGGTGGGGCTGGAAACAAGGGCCGCTGACCCTTCATGCCGGCCGGGACCTGCCACTAGCCCCCCAGCCTGCTTCTTCCCCTTAAGCTTCGTGCCCCTGGATGCGCTAACATTCGCTCTTGTTTGTTCCTGGACTGGCCATGAAGTGAGGAGATGGTTATCTAAAGAGAATTCCCTATTTATTTGACAAAAAATCCAGTTAATATATTAATGTGAAATAAACCCTGTTTGCACCTTGATTTGTTTGCTGAAAATGTGAAATAGTAAAAATAAATAACTGGACCC + DCFED):6G#FJJKI>CGH:JFHIDIGF=AE>6@779GHBFBDEGFJFJJKGIGFIKC?FKIAHJJHAEBHI6IIIJIIIHBB?=@/HKJIJ;FCFIII=CABAEJKJI2J;IJKHIAIKBFBJKGD@E=JKIJIJ@KIJIKFIKGGDKJH5HG7IG:F;GIK;B96.@EE4@AB>=<=>EGIFIDK,GHI@IDKGE;F=IF?GA7F9I7HH;EA?=A@2=F6HKIJHIH/KCCG@DFBE@K(GHKI@H4AHDIH8E;@F@E=D?;HICBDAGH7BC7CGCHFIKJGJIIKIAFIKF@?<=C;B?DG?9DG>D1ICI8F=85D>GBB:4)<57CCCF8=GAE3G=D9=EC?G<:IFHIECDEDEIGI;BGHE6GG?EC:HC6EF6JJFAE5?@7FGBEFCGCCFIHBDDBIHH;?@=>=?>?3CBFG?F;A:GHDHH7H>GF8FD?A?A@G5>GG;==C<@DC>GFC;H=:@CC>AB>8G8BF;?>@(B@I-HH;GBC8F??C=DCCBC6B3%=='&77CD1DD?9IAFC4DD:C>HEEIIH=8?HH;CGDAA$?ADF?CIACH=EEBBAFEIG4CAEI64G?I?DI8FHCGI-93DAHGA>7FIGID?CH8DIG>FHDH>D?B9HJEECFG0HHHEBGG?GJIDEIHJAFDGGHB=B%=DAEGJFJ@E6@HHE>7DG;GAG>JICIIIFHCD@FAH>FHDIB8EEFJFIH:?IFGDHDIDHBC7GHDBHI@FFHBCDIH?;@>AEBA>F?HEEBGFAEFCGIDBBB)I?JJ6HIGAEJFFDFIIBHBDG>D?IC:C??IHDE8>FCECGCBAEHAE9>?AFA@BGBFHIGH6GICJHGBICIGH@HEE;F?F8?DDIJAIHFFF9B:?EE8G;CIIADHE3BFHHCHEG@HIHDFI@DEHJI=DF3@FCCJCHE=CCIHDC>CE:FAHJCA?G:CE9F;EHDDI8B/CHCJFDIICBGG@CB9:>1HHF=FG;EDHI?GJIGBEDC@EDHFEA?DC68AIIHIFJF7F@AC>E?;>B@E?:E?;;@?D4CGEBAAEBB@4;ABD7E=EADC0BE:=7%%&<=C@=BFBGAAC??D9C9B:?A/>EB=@@AFB>5=<;A=E:A=B?;?D@.?A:EBD8;7F@@9D5@EBFFAE/@GEA?B=EB=B9=;CB@??*4A*B3B?>2/:0BB>C:D;@ABD?ABFE?C:BG@?ABB@>CE4D>>?@@AE,AFCB??3E=8>C>C6E?A3CB?EA?ADADFB:;CAFBC7>7;=ACA=1?D=8>89<;D>63698*9.,136.94:.5-3&8<39+'+%2449:.<8/+-(9;:9><5366-,*-13<61=:775:61'771:8:28855312))38:39023357;;::$..(288:=56:6711=>>>1/3;<>:=9:=>.8/'#2$33;;;,884;:=,<,797913174;:<+=>)6>339?;724683==/499=8<<:937787:8.;2774;88:,5;:-(7198&56.77%87:;;<2<<938;8;2:=83556;<7:117/59>22?88;)89':7%7$76:6?>7>4;8><973,69987'6256<=912*/;9967678>=&3:::.58-=0=488.70757.989>7878:;;684(9=:01623554399:80815/5782*+34*8<.78/873>901?=;966878815=4..17;.:6-<785/)3,862/3:18;807+6?587<>7:<2:76;7:15216/>:2662'>6=?95437>;:989>96,127487447*;8533029:=5*86:0.5/;-/30,/$511013,+-2631.0106$*00'.3143100/'86715*2,;44'*/35::)7<.;>86<364844;78.669854&,,;;720<89'98739=)75<=77<28;>?=;79/411831;::4..><-2<;:<3??=938=8>>=3;*/;;87(98091//17<6;<,:<=(>655*3/98>2<721/36,#44(46337173/.5.45:895.9;9:57-86=?5:9/:8*?<5,1.=:254.):;31278:;?>=3;0:585;?4::=9??1>4?;45=+7:;5=5><=>89998*895<148);8>9;5;>0=>:-4:)39*::66837;71:9779<<81.85:6:22*-48:6::461938=979902;:8<95,20=;3:87/04+37043,:;3.+&'(;=86-8863.3&,68<6059995:.,74562979=(=::9:<=3<<77893==08769789';;>==827:5=;<746<::9<:7<9.5<73;6228:77674:.<63;-94=7:3311-6367405358385955:97/55,146+04,60,84647724-99-*0/8:54:95:949;6804662&3+/3*78::964&.93::-/'624-8303070./3;57+33,#+51.7433670:3953413&51(,+)/1.'$'%*'%(,'*),-,),)-..&'#*)/*/,)+.)+-%&#)*)"%())+),+*&('/'+%#$$*-))&''&&(***,*/0(00+-)'*&(./**.+)*&((01*0),,.-*./0/&0.(*0*'$"'"%,),.+...&*-,-+%*+(,&)%%$%)*++&)&.&.-*)')%%%&+*+%$$$%,*,(*+'*&%,&+-.%,1*,,*+,'-.')+(*.,..%(,+1.0.0-011)(((&%''*+*-)$$,.),%+*('-(+.*--+2111.-..'.&/.1.1-1,.)-****'%,-'.0*.,0/*02,&)&%-+.-0//,*))(++))-.'*'%'**&+)%('&+)+(+%+&+'&%.(.--#$)/.,',0(*&,..,+*''(+&$"$&&*'*((*')()("$%(&++,,)%/.*02/,.,-1/-+)'&(1,//.1++&0..+*,+.,.%,-+-/*,'/0,-0+)'%#%(&(+$.,)#(+&&+--'+&-,-11..,,-01/(0++,2/1110,/..+.+/)-.-*,10/(-**-)2/,++&-$$%&(%%#*,-)/)/.+**0.*/,).)(-.'--''%+//2/.*/(0/0.-*&.(0-*/-$$ @rCer/856/25_1752_CCS ATGGGGGCTGTCGCCGCGGAGCCAGGAGGGAAAGCGATGGCTGGGCCCGCGTGGATCTCCAAGGTCTCTCGGCTGCTGGGGGCATTCCACAACCCAAAACAGGTGACCAGAGGTTTTACTGGTGGTGTTCAGACGGTAACTTTAATTCCAGGAGATGGTATTGGCCCAGAAATTTCAGCTGCAGTTATGAAGATTTTTGATGCTGCCAAAGCACCTATTCAGTGGGAGGAGCGGAACGTCACTGCCATTCAAGGACCCGGAGGAAAGTGGATGATCCCTTCAGAGGCTAAAGAGTCCATGGATAAGAACAAGATGGGCTTGAAAGGCCCTTTGAAGACCCCAATAGCAGCCGGTCACCCATCTATGAATTTACTGCTGCGCAAAACATTTGACCTTTATGCGAATGTTCGACCATGTGTCTCTATCGAAGGCTATAAAACCCCTTACACTGATGTAAATATTGTGACCATTCGAGAGAACACAGAAGGAGAATACAGTGGAATTGAGCATGTGATCGTTGATGGAGTTGTGCAGAGTATCAAGCTCATCACCGAGGGGCGAGCAAGCGCATTGCTGAGTTTGCCTTTGAGTATGCCCGGAATAACCACCGGAGCAACGTCACGGCGGTGCACAAAGCCAACATCATGCGGATGTCAGATGGGCTTTTTCTACAAAAATGCAGGGAAGTTGCAGAAAACTGTAAAGATATAAATTTAATGAGATGTACCTTGATACAGTATGTTTGAATATGGTACAAGATCCTTCCCAATTTGATGTTCTTGTTATGCCAAATTTGTATGGAGACATCCTTAGTGACCTGTGTGCAGGATTGATCGGAGGTCTTGGTGTGACACCAAGTGGCAACATTGGAGCCAATGGGGTTGCAATTTTTGAGTCGGTTCATGGGACAGCTCCAGACATTGCAGGCAAGGACATGGCGAATCCCACAGCCCTGCTGCTCAGTGCCGTGATGATGTTGCGCCACATGGGACTTTTTGACCATGCTGCAAGAATTGAGGCTGCATGTTTTGCTACAATTAAGGATGGAAAGAGCTTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTGAAAGATTTAGATTAATGCTTCTACGACTGGTATTTGCATCAGTCACTCTAAATGGACACCACATAAACCTCTATTAGAATACCTACGTATGTATGCATTGGTTTACTTGTTTCTTGACAGTACATTTTTAGATCTGGCCTTTTCTTAATGAAATCTGCGCAAAGATGCAGGTGGATGTCCTAGGTCTGTTTTCAAAGAACTTTTTCCAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTGTTTTTTTGTAAACTCTGAGTGGACTGTATCATTTGCTCTTCTAAACCATTTTACACTTAAGTTAAAATAGTTTATCTTCAGCTGTAAATATCAGGATATAGAATTAATAAGAGAAAATGTCTAACTTTTTAAGAAAAACCTTATTTTCTTTGGTTGTTGAAAAACATAATGGAAATAAAACAGGATATTGATGTAATAGCACAAAATGACACTCTTATAAAACTAAATGGCACAAGAGAAATTTCCTGGGAAAGTTCACATCAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAGACAGATTTGTCCTTTACAGAAATTACTGATTATGAATAAAAACTTCAGATCC + CJ+HKKKJIKKIJFKKK*KKK@KHEKK4KKEKKKKFHKHKKK5KK3KKIKJIEKKKJJ3IFKDKKKKJKK1KIHKJJ%KKKKJKHKDJJ-(K$K?8JKK=B7KIIJ:KJKJ7K0KKKKKKFKGEKKKGKKJKKKEKKFKK6KKJKIK5KC>KKKKKEKFJ;HKK3KKKKDKK1KKKKKKKKKKBEKKKKKKKKKKKKK;K=KJ7KKJKKJKKEKKKKDKKKDKKJIKJKKK+KKKKIGKK>KJKJJKKKKKIKKK@KKK;K?KKKGIKKJK>KK=KJKKHKBKCIK6J?KKKKKKKKKJIKK?KKKKKKEKKKDK=KIIKKKKGKHKKKKIKKKKK5KKKKKKKKKHK?KKKKKKKKKKKKKHHKAKKKKKJKKKJKCCKKKKKK%KKKKKKKKKKHJKKCKKKKKGKKKJ;KKKKHKKKKK0KKKKEKKKKJJKKJKKKJKKIKKGKFKKK9KKKKKKKKHKKKKKHKKKKBKJKGKHKKKKKIKKKKKKKKKIKKK'KKKFJKKHKKKJKKKKKKKIKKKHKKK8KKKK?KK4KKHHKKKKKKJKKK)KKKKKKKKKJGK7KCKKKKKKJKKK=KKKKKKKKK&KKKKKKKAKKKCKKJ6J'KIJ?KKKJKEKKKKKKKKKKK)KKKK7KKK;KKK4KKGKKKKJKKJKK@KKKKIKGKEKK9KKKKKJKE>-KKKKKKKKCKKKKKJKKKKKKJKKKKIKKJDKKKKKKJKKKIKKKKKJKKKKKKKKKKKKCK2KKKKKK:KKKKKKKKKKKKKJ:KKKKKKKAKKKKKJKJKKK)KIIKKJE?KKKKJGKKJKK)KKKKAKK5KKKKJKKKKKKKKK8KK?KKKKKKK;KKKKKKKKKK2K=KKK4KKKKAKKJKI5KKKJKFIKKKKKKK3KKKKKKKKJKKEKKB>KKKIKCKKK)KKKKHKHKGAKK=KKKKK3KKIKKKGKKKKKKK$KKKKKKK6KGJJ,KHJBJ2HKKKKKKKKEKKHKK6KKKKIKKKKKKKK2KKKK=K;KKKKKK?KK>KHKJKK;KKKKIKK@KKKKKKKKKKKKKK @rCer/858/465_75_CCS ACATTCTGCTCTTTCCAGATTCTACACTGGTTGCCTTGGCGAGGGTCACAATGAACCTTGTCGAAAGTCCAACCTGGTCAGGCATGCCGTAGGAGGTCGTTGTTACCAGGCTGGCCTGTGGTCCACTATCACCTCTGAGTGCGACTACCTCCCACTCCCGCTGTTTATTCCCACCCCTGGCTTTGGTGGCCCCCGTCCTCGCGGAAAGCGTCTCTCCCATGTGCCTGCGCCGGTGAAGCAGTAAAAACGCACGCAGGGCGGTCCTTTATGATCTCAGCAGCGTGGCGCTCCTCACCCTCCCTCCTCCTTCTTGCTTCTCACAGCCTCCGCAGTGTTGCGGTTTGTGAACCTACGCCCCCACCTCCTGCCAATAAAACAGTTAAGATCGGC + !-..)/./.--,#%-)..."+.-.'---&(&$.*.&,.*-"-&+("-..-..+&-..+)--%--$,"*-+&%&)#"$(---&"..-+.).*.).,%--"$*..$.--/',+(.(--./.,&#*+.%.*/,/.+-..$-"..+".,"-..(,,*..&+++"-..##,..).,+.-,*-./+.")$/+-.&**%&,/*---*/#)&/')+$-/..,#,)'////.*...,/+..($.&,/../#*%$*,$.)-"/.)*$,./+#*,.#&".$."./,-/.-.#,$*%"++,*("#,-++*,++.'-.-..'.'*%-.**.-////+."+,&#,(..#+.(/+.$"#,*/#.(#-./*,)*+.-,)*,*&$*,-..*%-.,.$%"+///./+, @rCer/859/25_2205_CCS ATGGGAGAGGCCGCTTTCCTAGCTCAGTCACCAGTCTGTGTTGAGGAAGGGTTTTGCTTTTTGTGCTCTGTATTGGGAAGGCAGATAAAATGCCAGGTCTGGACTGCCTCTGGGGATAACCTCACCCTGTGGGATGTGAATGAATAGCATCTTGCCTGGTAAATCCACAGGAATTGATAAGGCAGGCGCAGTTCTCCCAAACAGGCCTTTTCTCTTTAAGCTCTAGCTGTGGTTTCTGCAGCAATTTTGTTTTTGCCTTGAAAGAGGTGCTCTGGATTATCAGACCTCCATGTATGACAATTTGTACCTGCATGGAATTGAAGACTCGGAGGCTGGTTCAGCGGATTCCTACACAAGCAGGCCGTCTGACTCCGATGTCTCTTTGGAAGAGGACCGGGAAGCAATTCGACAGGAGAGAGAACAGCAAGCAGCTATCCAGCTTGAGAGAGCAAAGTCCAAACCTGTAGCATTTGCCGTGAAGACAAATGTGAGCTACTGCGGCGCCTTGGACGAGGATGTGCCTGTTCCAAGCACGGCTATCTCCTTTGATGCTAAGGACTTTCTACACATTAAAGAGAAATATAACAATGATTGGTGGATAGGAAGGCTGGTGAAAGAGGGCTGTGAAATTGGCTTCATTCCAAGTCCACTCAGATTGGAGAACATACGGATTCAGCAAGAACAAAAAAGAGGACGTTTTCACGGAGGGAAATCAAGTGGAAATTCTTCTTCAAGTCTTGGAGAAATGGTATCTGGGACATTTCGAGCAACTCCCAATCAACAGCAAAACAGAAGCAAAAAGTGACGGAGCACATTCCTCCTTACGATGTTGTGCCATCAATGCGTCCGGTGGTGTTAGTGGGGCCGTCACTGAAAGGTTATGAGGTAACAGACATGATGCAGAAAGCCCTCTTTGATTTCCTGAAGCACAGGTTTGATGGGAGGATATCAATAACGAGAGTGACAGCTGACATTTCTCTTGCTAAGAGGTCTGTCCTAAATAATCCCAGCAAGAGAGCAATAATTGAACGTTCGAACACCCGGTCCAGCTTAGCGGAAGTACAAAGTGAAATGAAAGAATCTTTGAGTTGGCAAGATCTTTGCAACTGGTCGTTCTTGATGCAGACACCATCAATCACCCAGCACAACTTATAAAGACTTCCTTAGCACCAATTATTGTTCATGTAAAAGTCTCATCTCCAAAGGTTTTACAGCGGTTGATTAAATCTAGAGGAAAGTCACAAAGTAAACACTTGAATGTTCAACTGGTGGCAGCTGATAAACTTGCACAATGTCCCCAGAAATGTTTGATGTTATATTGGATGAAAATCAGCTTGAGGATGCATGTGAACATCTAGGGAGTACCTGGAGGCATACTGGCGTGCCACCCACACGACGAGTAGCACACCCATGACCCACTGCTGGGAAGGAATTTGGGCTCCACAGCACTCTCACCATATCCCACAGCAATTTCTGGGTTACAGAGTCAGCGAATGAGGCACAGCAACCACTCCACAGAGAACTCTCCAATTGAAAGACGAAGTCTAATGACCTCTGATGAAAATTATCACAATGAAAGGGCTCGGAAGAGTAGGAACCGCTTGTCTTCCAGTTCTCAGCATAGCCGAGATCATTACCCTCTTGTGGAAGAAGATTACCCTGACTCATACCAGGACACTTACAAACCCCATAGGAACCGAGGATCACCTGGGGATATAGCCATGACTCCGACATAGGCTTTGAGTCTGATGAAACAAAAAATATTCATCTGTTGACAATTTGCCATAGCAGTGCTAGGATAAACCAATCATCTTAACTTGGCTAACATAGCACAGTATTTACTGTGCCAATGGGCTGCTGTCATTTTATGCTAAGTAAGGGGCAAAAAAAAATTACATTATGCCCTTGAGTCTAGATGGATATTAGATGCCCGATCATATAGATATTTTTTAAGTGCAACATTTACATGATAACAGTTACATTTTGTTTTCTTCATAGATTTAGACACATCAATTTGTAATTTAGGGTACTTACAAGGCACATATAAAATAATTTCCCATGCTGGAAATTCCAAATGACCAGTTCCAGTTGGAACCAATTTATAAACCAATTCCTGTTGGAATTTGGGTGAATTGACTAGAAAGTCTACTTGAGCATGTTGTAATCAATTGAAAAATCTG 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@rCer/861/2476_58_CCS ATGGGGACAGCCCCGGCGGCGGCACGACCAGCGGCGGCCAGGCGAGCGCGCCGCCCCGCTCGGCCCTCCCGTCCCGCCCCGCCGCTCCCTCCCGCACCGCAGCCGCCAGCGCGGCCTCCTGCACCATGTCGGTGCCGGGCTTAAGAAGCAGTTCCACAAAGCCACTCAGCTTCCAGAGCTAAGCTCAGCATGATCAACACCATGTCAAAAAATCCGTGGCCAGGAGAAGGGGCCAGGGTATCCCCAGGCGGAGGCGCTGCTGGCGGAGGCCATGCTCAAATTTGGAAGAGAGCTTGGAGATGATTGCAACTTTGGCCCAGCGCTTGGTGAGGTCGGGGAGGCCATGCGGGAACTGTCGGAAGTCAAAGACTCTTTGGACATAGAAGTGAAGCAGAACTTCATTGACCCTCTTCAGAATCTTCATGACAAAGATCTTAGGGAAATTCAACATCATCTAAAGAAGTTGGAGGGTCGACGCCTGGATTTTGATTATAAGAAGAAACGACAAGGCAAGATTCCAGATGAAGAGCTTCGTCAAGCTCTAGAGAAATTTGATGAGTCTAAGGAAATTGCTGAGTCAAGCATGTTCAATCTCTTGGAGATGGATATTGAACAAGTGAGCCAGCTTTCTGCACTTGTGCAGCTCAGCTGGAATACCACAAGCAGGCAGTCCAGATCCTGCAGCAAGTCACGGTCAGACTGGAAGAAAGAATAAGACAGGCCTCAGCTCAGCCTAGAAGGGAATATCAACCTAAACCACGAATGAGCCTGGAGTTTCCAACTGGAGACAGTACTCAGCCCAATGGGGGCCTCTCCCACACAGGCACTCCCAAGCCTTCAGGTGTCCAAATGGATCAGCCTGCTGCGAGCTCTGTACGACTTTGAACCTGAAAATGAAGGGGAGTTGGGATTTAAAGAGGGCGATATCATCACACTGACTAACCAATTGATGAGAACTGGTATGAGGGGATGCTGCATGGCCATTCAGGCTTCTTCCCCATCAATTATGTGGAAATTCTGGTTGCCCCTGCCCCATTAGGATGTTATGCTGGCTGGCTCACCTCCTCTTGACTCAGATAGTTACGGTTTAACCACTGCTTTGGTAATGCTGCTTATAACACATCCCAAGTGCAGGCCGCAGTGGTCCACGTCATCCAGCCCCACCAAGTGTATTTGGTTGACTTGTGGGCTCCCACAGGAGTCATGGTGATGGATGATATCCTCTTAGCCTGGTGGGCATGGCATGTGCTTTTTAAAACATCATCTGAGACCAGCCAGTAGTCACAGAACTGCTGTTTACACAGTTCTCAGGAGGCTGTGGTTTCTTAGAATATGACCATGAGCCACATCACAGAAAAAACCTTCCCACCGAAGATATTGTCTATCACCCAGGGGGCATCTGAAGGTCTTTTTTGCATTTCTCCATGCAAAGAGGAGAAAGCTTTTGCTTTCACACTGTCCCTTCCCAAATATGTGAGTCATGGAATTGTCAAAGTAAGCCTTCCCTCACCAGCAAATTGTCTCCTGATCTGAATGAATTTGTCTCTTAATGCATCCCTAGAAAAGTGTTAATTGTGGGTTCAAAGCATTCTCTGCAAACAGGCATCTCAGCTCTTCACACTTATGGCTATTTCTGAGGTATAGCCAGTTTTCTTCCCTCCTTGCTACTAAAGCCAGAGCGGTAATTCCAAATTATTTTTCAGTAAGACAGTTAATCAGCATTATTGTGAGAGAGGCTGAAAAGAAATTCTCCATTATGAGGAAATGGGAAGAAAATCTGGTATCCAAGCTTAAATTTCTTGGTGTACAGAAACTCTGTATGTATTTAGGCTATTTCTGAAGGGCACAGGGAAGGGGGAACAAATCTCTTCAGTTATATTTGTGAATTACATGTTTCATGAATCCATTTGGCACAGAGACACGAGGAGGAAAACACTAGTAACCATCTTTCCACTAGTTCATAGACTGAGAAACAGTAAATACCTTTCCTTTCCACTTTTACCCTGTGTTCTTTGAACATCATTTGTGCAGATTCTGCCCTCAATGAGGACCAAATAAAGATGATTTTTGTGCTAGCAGTTTAAGGTATATGGCTGCATATGCAAAACTCTTTCCCAATTCAGTCGCTACTTTTACTTCTGCCCCTTCTATCCATAATCTTCATTTGTGTATACAGTGCTGTGTGTAAGCTATCAGTGTTTTTTTGTTTTTGTTTTTTGTTTTGTATCAGTCATGAAAGTCCTGTTAGGTATCCCAGAGTTCTATTTATCTAGCTGTACAGACTCTTTCAGAGGTTTAACGTGCTGCTTCCGATGTGCCACCTGCAGTAGCGGATCATGTGGAGTGAAAGGCAAATCTTACTGCTTAATGTATAAACTCTCACCACAGGAAGCATCGCTGTTCCAATAAATATTGCTG 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@rCer/862/1959_55_CCS ATGGGGCCTTTTCTCTCCCGGCCGAGCCGCGGCGGCAGCAGCAGCAGCAGCAGCAGGAGGAGGAGCCCGGAGGCGGCGGTGGCCGGGGAGTCCATGGCGTAACAGTCAAGGAGGCGGCAAAAAAAAAGTCTGCTACTACTACGACGGTGATATTGGAAATTATTATTATGGACAGGGTCATCCCATGAAGCCTCATAGAATCCGCATGACCCATAACTTGTTGTTAAATTATGGCTTATACAGAAAAATGGAAATATATAGGCCCCATAAAGCCACTGCTGAAGAAATGACAAAAATATCACAGTGATGAGTATATCAAATTTCTGCGGTCAATAAGACCAGATAATATGTCTGAGTATAGTAAGCAGATGCAGAGATTTAATGTTGGAGAAGATTGTCCAGTGTTTGATGGACTCTTTTGAGTTTTGTCAACTCTCAACTGGTGGTTCAGTTGCTGGAGCCGTGAAGTTAAACCGACAACAGACTGATATGGCTGTTAATTGGGCTGGAGGATTACATCATGCTAAGAAATCAGAAGCATCAGGATTCTGTTATGTTAATGATATTGTGCTTGCCATCCTTGAATTACTAAAGTATCATCAGAGAGTCTTATATATTGATATAGATATTCATCATGGTGATGGTGTTTGAAGAAGCTTTTTATACAACAGATCGTGTAATGACGGTATCATTCCATAAATATGGGGAATACTTTCCTGGCACAGGAGACTTGAGGGATATTGGTGCTGGAAAAGGCAAATACTATGCTGTCAATTTTCCAATGAGAGATGGTATAGATGATGAGTCATATGGGCAGATATTTAAGCCTATTATCTCAAAGGTGATGGAGATGTATCAACCTAGTGCTGTGGTATTACAGTGTGGTGCAGACTCATTATCTGGTGATAGACTGGGTTGTTTCAATCTAACAGTGAAAGGTCATGCTAAATGTGTAGAAGTTGTAAAAACTTTTAACTTACCATTACTGATGCTTGGTGGAGGTGGATACACAATCCGTAATGTTGCTCGATGTTGGACATATGAGACTGCAGTTGCCCTTGATTGTGAGATTCCCAATGAGTTGCCGTATAATGATTACTTTGAGTATTTTGGACCAGACTTCAAACTGCATATTAGTCCTTCAAACATGACAAACCAGAACACTCCAGAATATATGGAAAAGATAAAACAGCGTTTATTTGAAAATTTGCGCATGTTACCTCATGCACCTGGTGTCCAGATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGAGATGAAGATGGAGAAGATCCAGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAAGAATTCTCAGATTCTGAGGATGAAGGAGAAGGAGGTCGAAGAAATGTGGCTGATCATAAGAAAGGAGCAAAGAAAGCTAGAATTGAAGAAGATAAGAAAGAAACAGAGGACAAAAAAGCAGACGTTAAGGAAGAAGATAAATCCAAGGACAACAGTGGTGAAAAAACAGATACCAAAGGAAACCAAATCAGAACAGCTCAGCAACCCCTGAATTTGACAGTCTCACCAATTTCAGAAAATCATTAAAAAGAAAATATTGAAAGGAAAATGTTTTCTTTTTGAAGACTTCTGGCTTCATTTTATACTACTTTTGGCATGGACTGTATTTATTTTCAAATGGCTTTTTCGTTTTTGTTTTTCTTGGCAAGTTTTATTGTGAGTTTTTCTAATTATGAAGCAAAATTTCTTTTCTCCACCATGCTTTATGTGATAGTATTTAAAATTGATGTGAGTTATTATGTCAAAAAAAAACTGATCTATTAAAGAAGTAATTGGCCTTTCTGAGCTGATTTTTCCATCTTTTGTAATTATCTTTATTAAAAAATTGTAC 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@rCer/863/22_4920_CCS ATGGGGTGACTTCTTCGGCCCCGCATTCGTGGACCGGAAGAACTCACCCGAGAGCGCCGGCGCGACTTCCTGGCCCCCTACACCTGAGGACCAGAGAACTCGCCGAGAGTGGTGTGCATATTTGCAAATAAAAGACTGCCACTTTCTTACGTACTTTGGCTCATTTTAATTACTTAGCTCTCCTAAATAAATTAAACAAACAGTGGGTGCGAACCGACCGGAAGAGACCCTTCCTCAACATCCCCTAGGGGTCTGAGGAACCTCCTCGCCAGCGAACGGCTCCCAACCCAACAGCCACCAACACCGAACAAGTGTTCCAGCTTTCCACTGGTGCGCTCTGAGCATTTCTTCTTCGGTGAGTACTCCCCTTTGGTTAACATCTCCGTCCGTTCCTGTCCTTGGCCTGGATCGTGCGCACGCCCAAGGACGTAGCCACCCTGTGGCGCAGTGAGGCTTCAACCCGGACACGTCCGTCTTTTGAAGTTCCTCAATTTCTCCGTTAGTGGCTCCAGGAGCCCCGGTCTCTAGCAGCGGCAAAGGACGCTTTTGCCACTGCGTGAGGTCGGTTTCCATTTCTGGTGGTTAAACAATGGGAACCTCACAATCCAAAATCCTAGGAACACCCCTTAAGGTGTCTCCTCCAAAACTTGGAAGCTTACATTTAGCTCAAGATTTAAAACGAAAGCGGCTAATTTTTCCTCTCCACAGTGCATGGCCGCAGTATAAATTAGACAACCAGTATCAATGGCCACCCAGACGGCACACTTGACTATAACTTCTATTAGATCTCTCTAATTTCTGCCAAAGGGCTTGGAAAGTGGTCAGAGATTATCTATGTCCAAGCTTTTAGGACTTGCGCTCTCGCCCAGACCTGTGTGCCCAGTGTTCAATGGCCCAGGTTTGTTAGCTAAAACCAGCCCTTGGCCCCACACCACAAGCGGAGGAAGATTCTACTTCATCTCAGATGGGGCCGACGTTCCGACCTACCAACCCCCTCCCTATGCTCCTCCTACCGCCCCTCCCTCACCCACTCCTCTTACCTCTCCCATTTCGCCCACACTCGCTCCAAGACCGCGGTAGCGGCCCCACTAGTCAGCCCTCTACCAGTCAGCCTGCCCACCCCTCTACCAGTCAGCCTGTCTTAACCTACCTACTGGTCAGTCTGTTCCAACCTCCCCTGCTAGTTTGTTGCCCCCCTCAAGAAGTTGCTGGAGCTGAGGGCGTGGTTAGAGTCCACATCTCCTTTTCCCTGGCTGACCTTTCCAAAATTGAAGAACGACTCGGCGACTCTCAGCCAACCCCACCCAATATTCCAAAGAGTTTCGATACCTAGGCCAGGCATATGACCTTACCTGGCATGACTTACATGTCATTCTTACTTCCACTCTTAACCCAGAGAAAGAGAGCGCATTCTTGCAGCCGCCAGGCAGCATGCAGACCAGTTACACTTAACTGACCCTGCCAGCCCAGTAGGCGAACAAGCTGTCCCATCTACAGATCCTGAATGGGACTACCAACCTCAACAACCGGCATCGCAGAAGAGACCTTATGATACAATGTCTCTTAGCTGGCATGCAGGCAGCTCTAACAAAATAGTAAATTTTAATAAGTTACGGAGGTTATTCAATACTCAGAGGAAAACCTGCCTCCTTTTTAAATCGCCTTACAGAGGCACTTGTACAACTTACCCACTGGATCCTACCTCTCTGGCAGGAGCTACTGTCCTTGCCACTTATTTTATTTCCCAGTCGGCCCCTGACATCCGAAAAAAAAAATTTAAAAAGATAGAGGATGGACCTCAAACCCCCATTCAGGACTTAGTCAAGCTAGCTTTCAAAGTTTTTAAACTCTAGAGAAGAAACAGCTGAGGCTCTTCGACAAGCCAGAGTAGAACAGAAGGTTGCCCTTCAGGCACAAGCTTTAGTGGCTGCCCTCCAACCTGCGTTGCCCACTTTGCCGGCAGGAAAACCAAAGATAAGTCTCTTTAAGGGCTCCTGCTATAAATGTGGAGACCCAGGACACTGGGCAAACCAGTGTCCCAGGCCAAGCCGGCCACTCCGTCTGGTCCATGCTTTAAGTGTGGCACAACTGGGCATTGGGCAAAAAGGTGTCCAAATCCTCGCCTTGCCTACCAATGCCGTGCCCAACCTGCCAACAGGAAGGACATTGGAAGTCTGATTGCCCCGCCAGCAGGGCAGCATTGCGCCTCAACGTGGTGCCTCTCCTCAAAGGCCGGAAGGCTCCTTCCAGCTCCTACACCTGGACGACGACTGACGGTGACTACACTCGGAGACCCCAGTCACCCTTGCCGACCCTAGGTAACTCTACAGATAGCGGGTAAGCCAATTTCTTTTCTCATCAATACGGAGGCTACCTATTCTGTTTTGCCAACCTAATGGAGGTCCTAGCCAGCCATCCACTATCTCAGTAGTTGGGGTAGATGGTAAACCGTCTAACCCTCGCCAGACCCAATGTTAACTTACTGCCCGGACTATGCATGCTTTGCCCACTCTTTCCTCATCATGCCCTCTTGTCCCACCCCCCTCTTGGGACGAGACATCTTAACCTAACTCAAAACATCTATTCCCCTTCCCTTTCTCCAGGTGACAGGTTCTACTCAAGGATCAACACCCTCCTCAAATTCTCCTGCTTTCTCACTATTCTCCATCTCAACTTAACTGAATTTCCCTCATAGACCCTCTAGAAACCTTCCTTCCCGACCTTCCCCGACCACTGGTTTCCCGACTTTTTACTCTCATAGAAGACCTAGCTTGGCAAGGTGCCCTTTATGATTTCAGCAATGTTGAACTTACCCTCTACACCTTTGTTACCACTATTATGGTTCACTCTAATTATTCCTGCTAGCCTTACTAATCCTAAATTTGTATGGAGATTTTCTTGTAACTGAAACCTGGTCTACTGACAACCAGGCTCACTCACAAACGCAAGGTACTGCAGATTGCTCCCCCCAGGCTGCCAAGCTGCCTCCTCCTTAACTTTCACCTGAGTTCTGTCGGCAACTACGACCACCCAGTCATATGTTTCTTGTACGACCAAACTGAATATAAGTGTAAAAATGACTGGCAAGAGACCAACCTGGGGTGTCCTTACAACTATTGCAACATGCATGAGATAGGTTTAATGGGTGCAAATGGCATTTGCATCCCCAATGATCGACCTTTTGTAAGAAACAGAACATCAGGAGGATACATTCTTAATATTAAGGATCCCTGGGACCCCCGGTAGGCTCAGAGAGTTAAAGGTGGACTATATGCAACATCTTGGTCCTCATATCCCACCGCAACCCTCCAAATAGAGTATAGTGCAACAAGTACACCTCCCTAAAAGTAAACAAGTACATCTTCCTAAAAGTGTACAGGCCCTACAAATTTAACCTCTGTTGTAAATCTCATGAACAGAAAATACAGAAGCTGTTAAGCCCCCCAAGTTCCCTAATAAGGAGGACCCATTCTCATGGCTAATACTTATTCGCAGGGACTTAACCCAGGCTGCTAGAGTAAGGAACCTCCCACTGCTTCCTTTGCGCTGCACTCGGAAAGCTCCCTTAGTGGCAGTCCCGCTACCAACCGCTTTCAGTATCACCACTGACTCTACCAGCTCCTCTCGAAGCAACATCCTTGCCTCAAGTCCATATACCGTAATCCACAGAGTCAAACCCTTCCTTTTTGCTTCTCTACTCCAAACTCTTTGTGGTGTGATTGCACTCAAGCTCCCAGCAGGACCCAGACGGCCCCCGTTGGAGGCTACTTTTGGTGTAATTATCGGGGTTTCCTAGCATCGTCCTAGTAGCCTCAGGACTTGGAACAGGGGCCCTCACCCACTCGATTCAATCGACACAGACCCTCTCCACTCAGGTCCAGGCAGCCATAGAGGCTTCAGCTGAAAGCTTAGCCTCTTTACAACGTCAAATCACTCAGTGGCCCAGGTAGCAGCACAAAAATAGACGGGCATTAGATCTTCTTACTGCTGAAAAAGGAGGAACATGCCTCTTCCTAGGAGAGGAGTGTTGCTACCACGTAAATGAATCAGGCCTGGTTGACACCAATGTCCAAACATTAAACAAAATCAAAAAGGAGCTTCAACAATTTAACGCCCTTAACCCCAGGCCACGGTATGGCTGCTGCCTGTAGTACAGCAGATGCTTCCATTCCTAATTCCATACTAATCCTCTGTCTTATGTTATGTCTTGCTCCATTCTAATAAAAATTTCTCCAAGCCAAGGTCCAAGAGATCACCCAAGTCACCTTCAACCAAATGCTCCTGCATCCCTACACCCAACTGCCAACCTCAGACCCTAACTATGCCCCTCAACAGCAGAAGCAGCCAGACAGACAACGGCGCCCCAAATTCTTATAAATCAATAAGAGGTTGGACTGTTTGGGTGAGGGAGAAAGGAAAGATGGAGGAATGTGAACAAGAAGCACAATCCATGTTGCTTCCGCATCTTTCCTCACCAACTTTCCGTCGGTGGGAAGATGCAGCCGCGCCCAGGAAGATGCAGATCAACCGAGCATGCACCAGGTGACGTCAATCCGAAGAAATTGAAACTTACCCAGCCACGCCTATGGAGACGCCCTATCACGCCCTTATCCCGCCCACTGCCCCCCCTTCCAGTACCAATGCATAAAAGTCCACCGCCGGCAGGAGCTAGCGTGACTTCTTCGGCCCCGCATTTCGTGGACCGGAGAACCTCACCCAAGAGCGCCAGCGCGACTTCCCTGGCCCCCCACACCTGAGGACCAGAGAACCTCGCCTGAGAGTGTGCGCATATTTGCAAATAAAGACTGCCACTTTCTTATGTACTTTGGCCTCATGTTTAAATTATTTAGCTCTCCTAAATTAAATTAAATTAAATTAAACATAAACAACAAAGCTGT + 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@rCer/867/2290_56_CCS GTGGCGGCGTCAACAGTCAGTCGGGGTCCGGAGACTGTCGCGGCTGCTGAGCACTCGGCGCCTGGCGCTGCCAGGCGGTGGCCAGCAGTGTGCAACAGGAACCCGAGGTTTTCACTTCAACTGTTGATTGGGAACAGAGGGCATCTGCTAAAGTTTCAGATTCCATTTCTGCTCAGTATCCAGTAGTGGATCATGATTTGATGCGGTGGTGGTAGGCGCTGGAGGGGCAGGCTTGCGAGCTGCATTTGGCCTTTTGAGGCAGGGTTAATACAGCATGTGTTACAAAGCTGTTTCCTACCAGGTCACACACTGTTGCGGCACAGGGAGGAATCAATGCTGCTCTGGGAACATGGGGAGACAACTGGAGGTGGCATTTCTACGACACCGTGAAGGGCTCCGACTGGCTGGGGGCAGGATGCCATCCACTACATGACAGAGCAGGCTCCCGCCGCCGTGGTCGAGCTGGAAAATTACGGCATGCCGTTTAGCAGAAACTGAAGATGGGAAAGATTTATCAGCGTGCATTTGGTGGACAGAGCCTCAAGTTTGGAAAGGGCGGGCAGGCCCATCGGTGCTGCTGTGTGGCTGATCGGACCGGCCACTCACTATTGCACACCTTATATGGGAAGGTCTCTGCGATACGATACCAGCTATTTTGTGGAGTATTTTGCCTTGGATCTCTGATGGAGAACGGGGAGTGCCGTGGTGTCATTCGCACTGTGCATAGAGGACGGGTCCATCCATCGCATACGAGCAAAGAACACTGTTTGTTGCCACAGGAGGCTACGGGCGCACCTACTTCAGCTGCACGTCTGCCACACCAGCACCGGCGACGGCACGGCCATGATCACCAGGGCAGGCCTTCCTTGCCAGGACCTAGAGTTCGTTCAGTTCCACCCCACAGGCATATATGGTGCCGGTTGTCTCATTACGGAAGGATGTCGTGGAGAGGGAGGCATTCTCATTAACAGTCAAGGCGAAAGGTTTATGGAGCGATACGCCCCGGTGGCGAAGGACCTGGCGTCTAGAGATGTGGTGTCTCGGTCGATGACTCTGGAGATCCGCGAAGGAAGAGGCTGTGGCCCTGAGAAAGATCACGTCTACCTGCAGCTGCACCACCTGCCTCCGGAGCAGCTGGCCACGCGCCTGCCCGGCATTTCAGAGACAGCCATGATCTTCGCTGGTGTGGACGTCACGAAGGAGCCGATCCCTGTCCTCCCCACCGTGCATATAACATGGCGGCATTCCCACCAACTACAAGGGGCAGGTCCTGAGGCACGTGAATGGCCAGGATCAGATTGTGCCCGGGCTGTACGCCTGTGGGGAGGCCGCCTGTGCCTCGGTACATGGTGCCAACCGGCTCGGGCAAACTCCCTCTTGGACCTGGTCGTCTTGGTCGGGCATTGCCTGAGCATCGAAGAGTCGGGCAGGCCTGAGATAAAGTCCCTCCAATAAACCAAATGCTGGAGAAGAACTGTCAGAATCTGACAAATTGAGATTTGCTGACGGAAGCATAAGAACGTCAGAACTTCGACTCAGCATGCAGAAGTCAATGCAAAATCATGCGGCCGTGTTCCGTGTGGAAGCGTGTTGCAAGAAGGTTGTGGGAAAATCAGCAAGCTCTACGGAGACCTGAAGCACCTGAAGACATTGACCGGGGAATGGTCTGGAACACGGACCTGGTGAGACCCTGGAGCTGCAGAACCTGATGCTGTGTGCGCTGCCAGACCATCTACGGAGCAGAGGCGCGAAGGAGTCACGGGGCGCACACGCCAGGAAGACTACAAGTGCGGATTGATGAGTACGATTACTCCAAGCCATCCAGGGGCAACAGAAGAAGCCTTTGAGGAGCACTGGAGGAAGCACACCCTGTCCTATGTGGACGTCACACTGGGAAGGTCACTCTGGAATATAGACCCGTAATCGACAAAACTTTGAACGAGGCTGACTGTGCCACCGTCCCCCACCATTCGCTCCTACTGATGAGACAAGATGCAGTGATAACAGAATCAGCTTTGTAATTATGTATAATGCTCATGCATGTGTCCATGTCATAACTGCCTTTATACGCTTCTGCACTCCGGGAAAAAGGAGTACATTGAAGGGAGATTGCACCCAGTGGCGGTAGCTTGCCAGAAACCCAGTGGCCAGGGAACGTGGCACTTACCTTTGTCCCTTGCTTCATTCTTGTGAGATGATAAAACTGGGCACAGCTCTTAAATAAAATACAAATG + %#)'*,+',+,,(,(+',#$%(+'&#*-,,''%#$&((++,*)*%''(*(,+('(,-',&,')*))+(($'%$,++(!"%')$&,+(**&#)+)$#'%%*%+,&)+*&'))$+*++$)&%*,,*(+)'$-+(*&(#%&+-('%&%)--)),(,-+(((+&%(,)((%#,-+(,-,'&&&-),))()&-*)+',-+%#&$&*(+'+'&-++,,'(-+((,++(((,)$,**+&,)*+(+*+))+'--'('*&*)#$)+-,)())&'#*&))))+(*(&'%&$+,*-*(&+(*,#,,+,.,,+(+,++),(+(,,+-++))(++,-+*-+*((((&(+)',*))&-+#&(+)(*#%(*#&'-*,-,)()'(-*)'-,+,('%(&(*(%/,,-%,0%**1.-'**/)/1002/%$-0/&0.+$*'1.++,,+,-0,)&.&/+%+,%,-.&-+/'*&*'1'./1*&+,-%+*,(.$&-.0,-*)-'()+#")-''*,'..,,%(.+-)'+0(/0.,$&'&&**(('++*/&0+-2+*0,0111).',%///)1/*,(//*-02/,-.**1&*/11.1.(/1++.,+#&)/..*.--+),,-,0-('#(0+*.0'.(./,1-2/*-*/0-&+&00./.%*+-.*/,1.,1,0,,+)'%'.)%%+-')*.(,-+%)-%.$.0,/*&%,+'*,*)%+%'.*)')&-/%"&%+&*''''+#+-(*)())()*,-**+*.,2./+,&+*0,.-01.*()++.)**,%+../%*-/,*#',&0.-)*',((.-/))',+(00.')(-)),).,,11)%)(**)*',%*+(+&&'-*/&1+.)').+)$.0,/($'-0),-+,**&$&+2*.,.-.+'%-+,(*&-.-)(,*(*,.-)(+-1/,,+,*-/&/0,2,+*.',+%0,/''$(%#(*(,%)(,(&0.1,*,,+/0,*.-/(-(/).)./(,(6.&'/+2./115312/&-*541/%6321+$(5,+*20-'20/014'125/4431(4)/1*3650.()0-1013-(()#%()/3511/+1410543,24'(&+)244213/2)4++-3361/'3/,1$(.$')-&214+3))'%1*/+563/*501,-,%,)%-.*$,,&3*(./)(&(,).(/(-3-,'2+61+6+404-.)(21./6252/4/3-)-,%2)&+-'.3262/*0*&++/1++--.2./,2-0(/102*,/,/%3/...//('(*+&+1)*$/40-*6(16122,1-*00231/66-523.35.40*6&.-).*-3426.2,)21,-51'264-6188,9907'6.'-20-442994*-1,:3+2.607562+692-540%--,-9/6-0.8/-./66,667&/-89-'0714)390-7322+0&,%-++0,,&$'%(,4)*33335)104,/3/20+#).20(/,*$,-0-03(/101&(5/6/).4+3044--%--/&/+*$-*#)+-*(#011/+%/055646.4.-('*&./.0-4602.((+,3(-3//)*.1'5,12*341.*0.,10'&-0..*'$.1-0-+&*(%+,&'($'$()**++%2/,+(&.$.(+*+)**&**,*0-*1**$''-/'222-00/-//**&./,*0/))*/2*'+-%+-)/,**1,)0-,'$,12/.0/(,*(/)),.*%+%.-/,%,-+./(#$''').'),(*+.'+/0-2.0-',-(/+$*)+(+0-+/,+$0/-0*()+,/1.&'.,*%..-*)'&%),(($+0,/0.*%0/-*)+*11+(-%)+*,**+/***$)+/,*(&,))0.&.,...,'10-2/2/(0$&+0-0/+-&12/.&'0(,2-'0+/.(*++%+&.00)/*-'(2/--'**,.)%'(2.,*.+,-&+/.))%-*.,/-(1*.,/1,(+++0*2-.1(.,-./&,/1--00.121-&*')&/,-,-&+).**0.,-/*0(&.**#)*+*#"(%,.*/,'$2-+%*&0-,-&(,0/++),-,0-10.,(.-*-0+*--.++,%//,,/*,%()*&))#(..+$()(/')+'+0**+0++/&0+),)-)/1).,+1.$'*1,100&$1(-,)--,/'2-,.),./1)/.&&+&/+01)&/0+.+%-,1+&10+&**%&/0+,*(-'1-,10,2*0,*/.,0+0/12.*/-)*01,10*.//-,0,/,,%+//&*0*0.0+*',*+$')/&/.-,).1-,-,,(&$+-+,***(*.,.,(#* @rCer/868/2328_60_CCS ATGGGAGGCCGCCGAGTTTTCTGCGCTTCTTCTCCCTCTCTCCAGACGTCCTGGTCGTTCGGTCCTATGTCGCGCCGGGCCCTCCGGAGGCTGAGGGGGGAACAGCGCGGCCAGGAGCCCATCGGGCCCAGCGCCCTGCAGTTCGACTCCGTGATGACGATGACGCGGAAGAAGAAGGGCCCAAGCGGGAGCTGGGTGTCCGGCGCCCCGGGGGCGCAGGGAAGGAGGGCGTCCGAGTCAACAACCGCTTCGAGCTGATAAACATTGACGATCTCGAGGATGACCCTGTGGTGAACGGGGAGAGGTCCGGCTGTGCGCTCACAGACACTGCAGCACGAGGGAACAAATGACGGGCTCGGCGTGGAAACACAGAGAGCAAGACGGATGGAGATGTTGCCGGGACAGCGCCCCAGAGCAGTCTAATGCAAGTGGCAAACTCCGGAAGAAGAAAAAGAAACAGAAAAATAAGAAAAGCAGCACGGGAGAGCATCGGAAAACGTACTTAGAAGATATTGATCGCATCCTGGAGAGGATTGAGGACAGCACTGGGTTGAACCGTCCCGGCCCAGCTCCCCTGAGCTCCAGGAAAACATTCTCTAACGTGGAGCACAGACACTTGAATCCAGACACAGAACTGAAAAGGTATTTTGGTGCCCGGGCAGTCCTGGGGGAACAAAGGCCCGGCAGAGACAGCGCGTGTACCCCAAGTGCACATGGCTGACCACCCCTAAGAGCACCTGGCCCCGGTACAGCAAACCAGGTCTGTCCATGCGGCTGCTGGAATCGAGAAAAGGCCTCTCTTTCTTGCGTTTGAGCACAGTGAGGAGTACCAGCAGGCTCAGCACAAGTTCCTGGTGGCCGTGGAGTCTATGGAGCCGAACAACATCGTGGTTCTGCTCAGACGAGCCCTTATCACGTTGACTCGCTCCTGCGCTCAGTGATGCCTGCCGCTATTCAAGGGATCAGGAGATGCTCGAGACCTCGTAGAGCGAGCGCTGTACAGCATGGAGTGTGCCTTCCACCCCTGTTCAGTCTCACCAGCGGGCCTGCCGGCTGGATTACCGCAGACCCGAGAACAGGAGCTTCTACTTGGCCCTCTACAAGCAGATGAGCTTCCTGGAGAAGCGAGGCTGCCCGCGCACGGCGCTGGAGTACTGCAAGCTCATTCTGAGTCTGGAGCCGGACGAGGACCCCTCTGATGCTGCTGCTGATCGACCACCTGGCCTTGCGGGCCCGGAACTACGAGTACCTGATCCGCCTCTTCCAGGAGTGGGAGGCTCATCGGAACCTGTCCCAGCTCCAAATTTGCCTTCTCCGTTCCACTGGCGTATTCCTGCTGAGCCAGCAGACAGCCTCCCTGAGCACGAGCGGAGCTCTGCCAGGAGAAGGCATCTCTCTTGATCAGCAGGCGCTCACCATGTTCCCGGAGTCCCCTGCCTCTGCTCGAGTCCTGCAGCGTGCGGCCCGACATCACGGTTTCCAGTCACAGCTTCTTGGACCCAACGCCGAAATAAGCCAGCCCCTGCCCTGAGCCAGCTGGTGAACCTGTACCTCGGGAGGTCACACTTTCTCTGGAAAGAGCCTGCCACCATGAGCTGGCTGGAGGAGAACGTCCGTGCGGTTCTGCAAACTGTGGACGCCGGGGACCCTGCCGTGGAAGCCTGTGAGAACCGGCGGAAGGTGCTCTACCAGCGTGCACCCAGGAATATCCACCGTCATGTGATCCTCTCTGAGATCAAGGAAGCTGTGGCTGCCCTGCCCCCGGATGTGACCACGCAGTCTGTGATGGGGTTTGACCCTCTGCCTCCTTCGGACCACATCTACTCCTACGTCAGGCCGGAGAGGCTGAGTCCCGTCAGCCACGGAAACACGATCGCACTCTTCTTTAGGTCACTGTTACCAAACTATACTGTGGAGGGAGAGAGGCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGCCTGAACAGGCTGATGCTGGCCGTGCGCGACATGATGGCCAACTTCCACCTCAACGACCTAGAGGCACCGCACGAGGACGACGCGGACGGGGAGGGGAGTGGACTGAGCGTCCGCAGAGGTGCCTGAAAGCCCGTAATGTGTTGTGGATTTCTGTGCGGGTCAGAATCGGTCAGTTCCCTGAAGTAGAACGGCCGGACTGTATCGCTGACTCTGGTCGCTGTTTCTCCTCATAAATGTAAATGGGCGATGATGCCGACTGTATCGCTACCTGGTCGCTGTTTCTCCTATAAATGTAAATGTGT + -02.'**$..1,,.14556,40051551(++0/6634.1046/13453-250656241,40+/601/0,++1343-06.34*5503/2646523**,.2%4-1152//402/-/,.+&5-50105'.2.425450/52/353201/$.(.4/*-03322(.1-33551/%,4)04/64,04.324/40*5340.3*/4)544/150.1&53/4*/,/*35+5+(0*54/+*3/.555000.04&616664321021421,+%-,-.3+,45123/404.1/-.5505644.034-43-)$2..5,/6/40250*2,(+/0(.2153*1055441563(-2,2-000+45/254-0*/6420'50644003-01310250.+4313464201/43-+-*12$/400/.200'0546611+/10+0554*3.3.03/*02541*0&44*45322//1/'42/043.&*/,2113,55211221,%1/$*114240333*4'//..%*46235645/5665254/214341346,21#22505531112+01)3*32)23,#)-#2/55)44.+56654365356.4624.$(/2-./0011'-4663)2)*-*-46542*3405+.,12215645+,40246/63/4.+0%3.-14606612052+15.053)51/3'+*-/#&'++(*0022/563520040365524102100/20.1*20611343&-4+//50.1-55/414*13.0445/06-61,-)110-(0(/)035/0/5112/2-20-/.'&*$100.*/+&0././&/1,.2,-*-,*-+-.112.+(+).+1-,-2(0/10)+,11-11-.)0.,)2,-.1.01/11*0+,*/(0/))-$//11+0,().&/+,*-0*#+,-1,*+*.(*,,-**%+0-1011-+$&(&10%-0/**101-0.0(112,10)$1-120&++.,,$+,***++.1/++'.0++//%+*32**333/-+,(.5212)+5110,-3,//0.0,)*4-$/52+$156231,,&+.//-$*,/0.,/*-./(/5-51-/112(++,-.20-522.1+10+-+/0*+0+22,001112.+**01*,0100*2/120,1211-++211.+1....-,/)./*-*.-+'+(,*,-.)(+0+/+1&11.*)+(*'+0/''.%'&(-2100.,$&+&$+..'&,----11,-+011),*+..&-*1)/+.0&*1(1-20.0/..'0.1.-+/1/2.-0+--0+($))%*(+01(),,0,0.1121.*0,110//&)01+0%)0)0/&*.,-,-,,,-.(20*,0.+*,)%.#&'+01,0.-.,*,..10,,#*%*+,)(,+-*&+-,11.+(//)('/-,+%$.//,1*+$1/+&-1)&.,&)$%/,$$-*)+&'$''*(-'-/%,+10./$)&100**01//(00').1-*/0110)&01.+-1,,.&*531/044/,6.52,5.21-/23/-+1004/-0..-0,*)($*)*4501.0/3$05320,++,0---%$&%*&(.60)*+/*+.(-*%(/(*42/)/2.&,+'$,-1--*+-1**+2.---.*(&+--0-112100.0,)$),'.*+/*10+,'(*'**-#'0-,0,).-,-+.,$$()('.,'100/0)+,-1/&--.2---2/0,-1(.-*+.%)%+0-(//1*0/-+/(0...+-,0,.11/1+-+%&,(&.,+()&-),0+.01011,-$()('&/*++0-0&*-,,.0*20/-/(-0-'&(+0--.1-,01-)..)%#*#,,10-0,('1.'+))*,0(0-+-*),')'-'-/*,1*-**+&0)(('/-1+0/.,.)/.-..0*%-,.1&.*1/1,0110*0.-+-1-.'*1*.*+)11/-0-)()%###'-%+-,00+-+.0-(,,-.-)&($-00.)%/,*./0&,)(.*,&*0--+)//--0*2/*/$%''''&+)*#*',-+(&(-))&)&&,--+&&&')-**&#'-'',('&%&$+--)--'-)$#&%(%'(&#%$#$$%'%'&((%&(%%('%&'%&(((#'(%'##&$%&''%$)(&&%%')'&%%"'(&'%(&%$&('%&!!"##!#$%&$###"#$!#$'##(&#(((&)%"%())(('$(%)('''($#$$"$%$#$'#"())))))(($#$')$&$()((%$$%')'%#'%%%&$&&%&$())&"$$#((%#)%'%('()''%(($&$""'&$(%()'(%#(()('%((&#$$$)('#(((' @rCer/869/2485_51_CCS ATGGGGCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCCGTCTGCTCTGTGGACTCACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGCTTGGAGCTCGGCTGCGCAACCAACACCATCCAGTCACGATGGTGGACACAGAAAGCCCGCTCTGCCCCCTCTCCCCACTCGAGGCTGGCGATCTAGAGAGCCCGTTATCTGAAGAATTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTCGGTTTTACAGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCGGTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATCGAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTACCATTACGGAGTCCACGCGTGTGAAGGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGACCGCAGCTGCAAGATCCAGAAAAAGAATAGAAACAAATGCCAGTATTGTCGCTTTCACAAGTGCCTTTCCGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAAAAAGCAAAACTGAAAGCAGAAATTCTTACCTGCGAACATGACATAGAAGATTCTGAAACCGCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATGAACAAAGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTCATACACGATATGGAGACACTGTGTATGGCTGAGAAGACACTGGTGGCCAAGCTGGTGGCCAATGGCATCCAGAACAAGGAGGCGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACATCGGTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGGCTTCGCAAACTTGGACCTGAACGATCAAGTGACACTGCTAAAATACGGAGTTTACGAGGCCATATTTGCCATGCTGTCTTCGGTGATGAACAAAGACGGGATGCTGGTAGCATATGGAAATGGGTTTATAACTCGTGAATTCCTAAAAAGCCTAAGGAAACCGTTTTGTGATATCATGGAACCCAAGTTTGATTTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGCGATATCTCCCTTTTCGTGGCTGCTATCATTTGCTGTGGAGATCGCCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATGCAGGAGGGTATTGTGCATGTGCTCAGGCTCCACCTGCAGAGCAACCACCCGGACGATATCTTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAACTGGTCACGGAGCATGCGCAGCTGGTGCAGATCATCAAGACAGAGTCGGATGCTGCGTTGCACCCGCTGCTGCAGGAGATCTACAGGGACATGTACTGAGTTCCTTCAGACCAGCCACACCTTTTCCAGGAGTTCTGAAGCTGACCGCACTACAAAGGAGACAGGGGAGCAGCACAATTTTGCACAAATATCCACCACTTTAATCTTAGAGCTTGGACAGTCTGAGCTGTAGGTAACCGGCATATTATTCCACGTCTTTGTTTTAACCAGTACTTCTGAGCGCGTAGAACTCAAATGTTGGGGGTAGGCGGCTATCTCAGGACTGGGAAGATTAAGGAGAGTGATGCTCAATGGGCTGATTTTAACTCACCCGATGTTAATCAATGCACATGGCTTTAGATCACATTCGTGATTTACCGTTTAATTAACTGGTAACCTCCAATTATGGTCTGTCTTCCCCTACACCCTGCTTTTGACTATTGTGCTCCTTTATAATTCGGAAAACTAATCAGCACTTTTAACGTTTATAATCCTATAAGTCTAGATGTATCCAAAGGCGAAGTATGTAAAAAGCAGCAAAATATTTATTTCAAAGACTTCACTTCTGTTTCCTGAATCTAAAGAAAGACAACAATGCTGCTTTTTAATCACAGGATGGAGAATTTTAAAGACCTGTTGGGGCAGGCACAGTGGCTCATGCCGGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATTGAGACCATCCTGACCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCAGGGAGTTGGAGGTTGCAGTGAGCTAAGATCGCACCACTGTGCTCCAGCCTGGTGGCAGAATGAGACTCTGTC + =?EA@)=D7ADEBAB*@G4FE3BGCIFJI5JEG>IEEII=DACEIFE@DIHEHIHGC?F/9.FIFFFHFGAIGHEEG>2IDHFDDEC=D8EFI8GFFHGIGDEFH@A@FFD>GAFDEFGCEDC@&;B:B?9E@HJFB@:E/BCGAIHFBCC58<IHEGHB@=AFEABDGIC8>BEA=HGBCGBAGJ>HHIGJ@B@EEIABEAEIB9AB<@G5EEG8FFGHJC+;:E6CBDHEAA?EDAHI?E?IHI@GG/>>G87GHHFID?BGHF9?DCEGICCFBEH9GEH;FC@JDCEFI0DJJ9EC@HICFCIJFCFG@BHGIBGEC=B<:@CH?IDIFIIHBJF;?F2CGDE?<7BAF7?@;DGF7IIEG?=CFGG=DHIBE@HCCHJBGD;HIGFIJ?BDFB:FGC>?>%CC*BEFJC1EFC6CBGAGF@DFFG?FH>GD8HEHC7>C=JDEJEG6HGFIB7AED@;DGEFDADEHIHI@=IHBI8@DAHCHDDGJ=JFHIII?FFHHI>GAGFE.GEDHHDIE@CBD3C2:D7?EB>GGFI85>@FEGHDBAC6HEE:E=CCB6HDIGIGIDB:BFH3F@HGHJEJFF9BDEF@IHEIJB?BB=E=FJG;E@F;=A>GBAC?III?CC@FHAJD?A@7>@:G?E?D3B;FEBF:G9H@G?CFIBJEECBH=HGHB=E=3FFEJHH?DBF@3<>EC=?HHFF:D68BA+:5FDGCG@DFCAA?D@2'?C;?8?<@ED;;AA)>CE=@=BDD,AC4DA+FA=C5GDEEFC3DEDAACCA=9FBD;DA9C:BBE8DDGGE/AB8@?*;D@EFFGCG::BC=FCD;B<@DB?ABDF?A=9GGC8DFFD39?FE=BB??CE=?4::8@;;4CAD;FGAEB>EDD99=EG9D@C9GBE>EB:=+C<;8CCE9E<=CG8F:E?D@6?9CCA7D5BBAFE?EGF<@CCCC9BCDDCF/:GAA=?:C4@B;?@?<@EA=:B=99CA>59?EBFDCB=.BA@C=A@BCB@>8>@99B@=BE4AEBA;:7B:@7DC=G=GAEEFDE>CAA6?;<@@DG;3F>EE6@@A<8=AE;DDFD:C@AB?B>/@?D6FAD>A?DBEF,=8@AEABDE?717?A/G;CEAC:2DECAF?F?ACA=D5CBC4;A0AD5>@?;D?;93>GB/.>?A5C;E>;5@>;>:5CC,;?EC==:%=:558ACD8B<;>C?E3D?GBFEEAEECEFDE?>BA47@AABC/8>;@EED6CFDD>=(B0C6D9=>C6CF9@==:0;$D>D=D>>:5=>9A8>DG>@6BAAC9AB7>CE,CBCEEE=?CC;@F=>B5AB:5B6AFCFBAD;96C?ACE9D?DC=A==BD7FG9D>ABG=C;;CDDEFED)=FEEDDBE7?>BGBABA0EEG1A.7@EA687EDFC@B5C@EE<:6&7CE;:BDDGD?F:??FE2@433B989E=@EE-CB:<=F?BEC?BBE7AAD9>=89BDEAC>==@EF7>58===.9F*79E>=8E=DA=F@D3>AE:+2AD?BEC.A;?:AC??8ADE3EAB9D@>FA>%>B@@D)>AGCGFBB0A7FC=AE>>6%FCBDEB6FA::D<5A:?F8@EB@8;>;3?FD:AFE? @rCer/870/2297_62_CCS ATGGGGGGACGCTCTCAAGATGGCGACCTCTCTGGGTTCCAACACCTACAACAGGCAGAACTGGGAGGATGCGGACTTCCCCATTCTGTGCCAGACATGTCTTGGAGAAAACCCATATATCCGAATGACCAAAGAAAAGTATGGGAAGGAATGCAAAATCTGTGCCAGGCCATTCACCGTGTTTCGCTGGTGCCCTGGAGTCCGCATGCGTTTCAAGAAGACTGAAGTGTGCCAAACCTGCAGTAAATTGAAGAATGTCTGTCAGACCTGCCTCTTAGACCTAGAGTATGGCCTGCCCATCCAGGTTCGTGACGCAGGATTATCTTTTAAAGATGACATGCCAAAGTCAGATGTCAACAAAGAGTACTATACACAGAATATGGAGAGAGAGATTTCTAACTCTGATGGAACACGACCAGTTGGCATGCTGGGGAAAGCCACATCTACCAGTGACATGCTGCTCAAACTGGCCCGGACCACACCCTACTACAAAAGGAATCGACCCCACATTTGCTCCTTCTGGGTGAAAGGAGAGTGTAAGAGAGGAGAGGAATGTCCATACAGACATGAGAAGCCTACAGATCCAGATGACCCCCTTGCTGATCAGAATATTAAAGATCGATATTACGGAATCAATGATCCTGTAGCTGACAAGCTTCTAAAGCGGCTTCAACAATGCCTCGGCTGGACCCACCAGAGGATAAAACTATCACTACACTATATGTTGGTGGTCTAGGTGATACCATTACTGAGACAGATTTAAGAAACCATTTCTACCAGTTTGGAGAGATCCGGACGATCACTGTTGTGCAGAGACAGCAGTGTGCTTTCATCCAGTTTGCCACAAGGCAAGCTGCAGAAGTGGCTGCTGAGAAGTCCTTTAATAAGTTGATTGTAAATGGGCGCAGACTGAATGTGAAATGGGGAAGATCCCAAGCAGCCAGAGGAAAAGAAAAAGAGAAAGACGGAACTACAGACTCTGGGATCAAACTAGAACCTGTTCCAGGATTGCCAGGAGCTCTCCTCCTCCTCCTGCGGCAGAAGAAGAAGCCTCTGCCAACTACTTCAACTTGCCCCCAAGTGGTCCTCCAGCTGTGGTGAACATTGCTCTGCCACCGCCCCCTGGTATTGCTCCACCTCCTCCCCCAGGTTTTGGGCCACACATGTTTCACCCAATGGGACCACCCCCTCCTTTCATGAGGGCTCCAGGACCAATCCACTATCCTTCTCAGGACCCTCAGAGGATGGGAGCTCACGCTGGGAAACACAGCAGCCCCTAGCACCTTGTCACCACTCTGGGGCTCTGTGGAAGAAAGGGCACTTAAAACTCCCAGTAAATCTTGGAATAAATATATTTGTCCTTCCCTTGTAGTTTCCATGGTAGCTGAATGTGCTCAGATGTGGGCATTCGGAGACTGACAGCCATGCTTTCCTACACATGTTCAAAGGATCGATGGACCGTAAATAAGCTGCCGTTAACACATCTGGTTACTGCTATAACACGACTAATAAAGCCTAATGCCTGTTCCCCTTACCTGTGTGGGGGACAAGCAGATGAGTGAATTGGAATGTCCAGCAGAGTTACCATCCCAATTATATGTTCATTTTGTATATTTTTTGGGCGGGGGAATAATTGACCTGCGGTAAAAAAAACCTTTGACCATTTTATGTCCATTGAGTATTTTCCTTTTCATCCTGTTAAAAAAAAAGATAACTAGTACTAATCATTGGAGTGGCCTAAGTGTGATTTAACTCTTTGGAAGTCACACCCTCAGAAAGATGAGTAGAAACCAGCACCAGCACAGCCCAGATCTTTTCTTTCCTCTCCTTTTCCTCGTTTATTCCTAAAGGAATCTGACCATTTTTAAGTCTCTACGGCCCAAAAAAAAGACAAAACTAAAAATTCCTTTTTATTACTGTCAACTGGATGGAAACAAATTTAATGGAGCTGTGTACCATTGAAGAAACCTGGTGTCTGGCATGAAATTACTGTAAAGAACTTCCTGTAAAACACGTTCTTTAACAAATGAAAAGCATTGGAGCGTGTGAATGAAAGACTTGTGACCTCCTGCTGGGACTCTGATAGTCGTCAGCATTCACCTTCGTGTGTCTTCAGTGTCTCATTGTCATCCCTGCTTCTGTTTGGTCTTAGAGTGTTTGGATATAACTGAATTGTAGATGGTAAAGGAAATTTGATGTGTTTTTGTTTTTAAATAATTAAAACGGGTCAATTTT + 5161466-123455,541-46252352-)/-342015/4,505331.145.3-01,531'433/3603644462515*666-,)$)+1-160546622+36602-**+/1)66520/104/*1.*4*13210(1*/0+.,0026-65502.445262,*433.34335)3)53.**5*516633/1,()((*32/4-3.1664-0,506514.06446520/03524666/2&62/5+14,/1455/4/42-.1)3.202640536655/6305230302.0565,1,1215144664625206520//.02611566662203404$&0%0254-35-54-03&44001232646)465/0.4*34.50/4041--+-)23565615105552+55114424/05610&24-013*1532440211/,13-,3-044*.1-,2514,-312051100&)$04.1,/24/1.22-1,2)+044.4),12532215(4+56453-/-00)05-40-3.640+45.0022'/-*-0/*0/*++1*130.356461442656+-23%200.0-.5112.-56663(5020)2*/463,*/.--....50.121//%+/)0-/5..335*,44364415.'3015.-150//).256116646561./,-%-.*.6/-./0561114-2626245026+3-54+))+4**-.0011/,*//051()266213223403461,,3666044)55/35..2.3/42'6056604-'',-.**3,1366565656666355/-53146411)1/13,1/.4.+0/.056-)1)5661-150$1115,462/2356150-+41+4565.542,)%$,02..00132.)11.101,110543,4036152-&-51-531402)551/04,4652/6252222&64323(22121-..,*(-/202*104521/462*,)1,,1434055011)0/-/-)//,*4453636211/1,2611/032(-313,#1012026.41,540-//*46146/,./.654.0060553.)021262632/1232/342-0&)3/26162+.43113520403065*453/*.1,3/-+*+-210/1)/.*11-1/25-/22/1,.20443+35-1*0041+0,661*&)$'-4211*03251510.02-12,.2/.46602562-62)1).(,1+.320.+014222,1,04/*,.064534*45,002264,54131.32'*56210226364,05461/.0.24222-./23/13/52251-3+-*2661240--+5.234/-+25)541661633+2524.1223.542512461643545/544,/4*21-45454-,330*-01/215534.12*/+-).-02/35163601460,1-3113150,04/30265302-)..1,())5651614456154/1-$32*/5+222155/553351.1,1/23/+%.+5450$024261220065./3-535/,,.$216633200/-02.&//2//(+)'&%-.-,0./-3+2021.424000,356511/,,42+(.-%0/04/44264563/012634232(/0'...0.%-/-/-20505112662212340.1'0013-2+0(+000&,.12/,)4+1,541155065665/53)51356/31241/01&11563465231503*3041-50236056/1+0214/54463201555504/51+2-,1/./&55126652614/.(.1/5)636565+02879:87660.0'07845)278-33:67:.375-;788594187:;:499/769369.82:/91.12$9.8622454:6535&5541120%563574(775556..)51/756..51352:3%&'56758:;5:7689:5562974:2486210)+,73:7588/575-:72603-040;952,577-44-842+.8+10,.7/3390356)(*%04:2147/;6675-24699*22.94;:9561,/84433664633281:5:85354.25::99725446:973454:6845653(251'8.45994445:86.26:6365574355.,240410221-744.73769/51*217840:538555(23373644654304.083.78:6/89/654/3,692/$047;6132204142589.058,20656662 @rCer/871/2683_61_CCS ATGGGGCGGCCACGGCGAGCCCAGCCGCAGCAGTCGGGCACCAGTGAGTGCACACTCGGCGCCCGCAAGGAGAGACACGGCGAGCCCCCAAAGCCCGCACGATGCAGGCCACTGCCGATTCCACCAAGATGGACTGTGTGTGGAGCAACTGGAAAAGTCAGGGTATTCTCTTTATTTCAGTAGTGCATGCCTGAGGCGCACGGGAAACCCGGGACCCGGACTCATCCATTGTGCATCATTTCACCTGTGGGACCGGTGCATGCTTTATACCCCGGAGCTTTCTGTTGGGGGATAGTAAACCTGTTATTTCAAGAATCAAAATGGATGGTGCTTGTTGTTTTTTTCTTTTCTTTTTTCTTTAACCCCACCCCCACCCCTTTGTTTTCTTATTGTAATGCTGGTATTTTAAATAATGCATCAGTCGCCTCCTCTGGGAGTTCTTTTGGGATCTGTGGATCATTCAGTACTTGTTTAATGTTTCCTCATCGCCGGAGTTAAAGTGCTTTCTTATTGTTTCATGCATCCCAGTGAATTTATTTCTGCCCTAAGGTTAAAATCTCCTGGCAGAACCATTAACTGAGAGGGCTGGAGTGCATCCTTTTAAGAGGGACACACCCATTTCAGGGTTATTATTTGTGATCACACAAAGGAGAGTAGAGATGCAGACTAGCTCTCGAAATCCTGAAAATATGATGGCGTAGCCACATATTAGGATGGTTCACTTTGAAATATTTGGGTTTTTTTTCTGTCATTGGAGTAACCTGTGACTACTATTTATTAATAATAGGTATCTGTGAAATAAATGGAGGGAAAGAACGAAACAGTGCCGTGGCCCTTGGTATAACAGATTTATTTTGGAATAGTCCATATTAGCACTGGGTGTGGCTACCCTCCAGCCTCGTTTGGATTGCTTTTCAGCCATTTTTATTCAGCCTCACACTTCACACATCCATCTCTCCTTTGTTACATTAAAATTCACCTTGCTCAGTTACAGAGTATGAGGAGAAAGATAATTTGCAAGAATGAATTGTGTGTAGGAACTTGGGTGTTTGTCGGAGGTAGTGTGTCTTTTCATATTTAACAAAGATGGTTCTGAAGAAGGCGCGTTTAATTTAACCTGCAGGGTTTTGCAGCATCCCTCAGGAGACCAAGAATACTCTGGAGCAGCAGCTGATTCTGTAAAAACCTGGCATCTTCCCCTTGTAATTTTATATCACAGGAAGGATAGGGCGTCCTTTCCTCTTTAATGCCTCTGTGGGGTTTTGCTTCGGTATATATTTTAAGAAAAAGTAAACATAAATCTCAGAATTAAAAGCCTACTTACCTTCCCTCTTGTTTGTTGGATTGGGTGGCAATGACATAAAATCCAATCGTCTACTTCAAATTATATGAGTGCTGGAAATACAGTTGTCAAAAGTAAATCGATGGAGCTGATAAATTTAAAAGCCAGTAAATAAGAAATATATGGCAATTGAGGCTCAATGTTTTGAAGAATGATGACAATTACATGGAAGAGCATATGTTCAATATAGAAGGCAGCTGTGAAAATATTTTGTAACATTTTATTCTTGTTCTGTGTTTAGACCCATCCAGTTTATTTGATATACATACCTGACAAACAATTATAGCTTGATGTCATATCAGATGTAGTTGGACATAAACACTGGTTTTTAGACTAAGATTATGAGTTTCTAGTATTTTTAACAAAAGTAGATATTCAAAGACAGCAGGTTTTCTGTTCTATTTGTATAAGATATTCACAAAATCTTCTGAATTAAATATCTTAATCTATTTCATCACAATCTTATGCTTTTTGACTTGGTTGCCTCAGTTTATGTCTCCGAGGTTTAAAAAATCACATGGACTTTTATCATTAAAATTAACACAAAATGTCATCGTTTCGCCATTGAAGACGAAATAATTTTTCATTTCTGAGATAGGGCTACTTGTGAAGATTAATTGAAGATCATTGAGAATCTGTTATACTCAACGACCTGTGGTAGTCTTCAGTACCACTGATTTCCTTTTGTCAGATGGAACAAATCCATTATCTTGAAAATTGACTAATAAGTAACTGGATGGGAGGACTTATGAGCACAAAAGAGAAATTGTAAGGAGTGAATTATTCCTTTTTTTTCTCCTCACTGTGAGAACTTTTAACCTTAACAGAATCTACATTGAGGTGGTGGTGGTGTTGTTGTTGTTGTGTAGCATTTTTAGTGTATCCTCTTCCCTTTAGTTCCCTTATTATCAAAAACAGTTGTTCTTAACCCTGTCTGCCTGTTAGAATCACCTGGGAAGCTTTAAAAAACCACAAAGGATGCCTGGGCCCCACCCCTTGCGATTCTGATTCAATTGAGCTGAGTATCCGTATTTTTTTAAAAAAGCTCCTTAGGTAAGTTTAATATGCAACCACAGTTGAAGTCACTGGAATATTATTATTATTTTGTAGAGACGTTGTCTCGCTATGTTGCCCAGGCTGGTATCAAACTCCTGGCCTCAGGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCTTGAGTCACCATGCCCGGCCTGGTGTGTAATAATTCTTAGTGAGCCAAACCCATAGACCAGCAGAGGTCCAGGAT + JHJJKEJKFKCEJJGEJFIIKH@IKAJGIJIFFIJGK;HJKKKJHJJJDGCJJIJJKJHGHIKEKIKFK7JHGIKJEIKJIGIIJIIK3JH=HKKJIICIIJJBJDK@FDIHJHJ:ECJEK6JKCKCJIIIFICKIIKIJJJABJJKD3IJ>GKIHKEIJFFDDKHIKAKFIIGFIDKJHJIJE?GDGJ7FDCJC@>IAGEHKFAHFJKKKBAF>H=JJAJIKK4JHJG;IFKIHKK=KDJGKAHIIDJJHIGFJKDKHFJHKKKJAIEDGKJJFIFJGJJKK*5K1BHKHHJKGIKKKKHGDCDJHHGJIKFJGGJKKCKGDHGGIGGAGBCJKJKK1HGEGJK5HF>FK;JKKCJ=JIHGJKKFJHIKJIKKIJHHBIDAFK0GD7?EH7KIJCEFJHBDK?HJJF@KG@KIK>JJJF?AJKFI1EFII9GE?GJAIHJ>H;IGJI>FJGJGIKGKJKHFKEF?G?ABBFJKBIHIKHFGJCEGI=IHCJJKGHAKKJIIKKEEH:ABCE@HC:GKIB>BIHFIIJ&HJIGJIFJG28IC>HKIFKGHBEHJJFJJIGHJI8DHFJKKF8HFIG>IEJJ-HHJGGJ=HHJ?KKEG3E9=:DA:JJCBKK?EEIJ&KIHCHJFFIHJGJJ@IJJEHGE@33=HIJFJFCFD>JJIKHJGJJJJEJ3JJ@DDAEGJJIIEDK;IEIKIHKJCKJEK;GKJ=IFGHE?B@DKHKAKGCEKJ8KJIHJIHKJHII1JAGH?37CK6JKHI>CGJIAKEFJJIKFIGFJEFCJ?FHHJIKKHKAAJICJJIH;JCGKJHDGIJBGJKICJHKDFKJ?IKKI=KKI:JIKJ@HD52>FE?AIH9KDHJJKI)GIHJHHJ;IK;IKDHGFJ>IGJGJ>JI?HJKKCHKJKGJI?EEHDHIKJIHA@:JKJG=IEJ>HJCJHJEJJCBFKKKE>FJKHCIHIJJKKIIJFC&BJI5KK:KHI0JKHIIIHH=DJGJJ*>GIG8GFIHKK@GIIKHKKGI@IJJK@IHFIKDKFJHGGHG*DJKJIGKJJJ,BFH=DKJKK=JKJK>JJBAGKJGJIDFJ?D>JGFGECJIICIJ-4HKJ<+CIDD5JK@KJIII5BHK>KBHKJ/HHI@D>DGIG%IIIFHGIEDG9AHJDGK>JJGKCIEAD7@I;FDGH)G?>95;4HFH>69IH:HFHFHDI@FF8>?JHJHFDDIBHGCDGJEDBBHBHHED9;E68HFCEDFIIJFBHGFFG?C>?H@FCGBFHHCGHCEHGADEHGH3HHBHHDHGGF6B?H3EIBGH=EHEEADIHH?J?FFGAHDBIHHGF0HGBEEHHH;HJ?H@HA<(=@G=FEDDD*E>GIHBJEG?GF?@4I@IF@IGIJJJEA?9IIHIHCHHH@6@DHEAHHHG3D/CHC=E;ECHE=GDGH=EIICHF?EB%GI@HFC>DFBFGAHIHGD=DHHDD?BIDEDEFIGCIG5GEF6FHBHAEI>C9HGHEE6AEGH@IJGIECI?IIEI>ECGEEHHHHHFD)7D@>?#IIIHFHEIHGHG7?JJBD=B@BADI7F<:FBGHGGE;BIIHBIIEF=?DBA>IFDDA@DHG-FD?;HEHGDE1DFH?GEBFEEHE4GJHEHGHEDI;:A>>DC)GHDG9JAFDACEFCBJAAH<=JH@IGD@EBCF>:FF:EA7FECG>HGEGJ0EG?C5BFEE>D=8DGB>9@IJ?$/>;-8<><=%3BA<::84&3/%51(6?>39>A3A,<@?@;BBA5C>><:+>8CB;B7?@E7>DB?:@<=?DB=9D?600;94>B@,8D5B5;'=?B46C+?DA66>98:(5;>.8?8@47A8<8978799%,'2=77%/0234%11,98&+*.661/-&+112'-&-.05.-.+**##&0%$,-'4+#*4'2.4.))*+$&"""###!'#$+/'.+-.*/,*$''(+#+)*-0-1/-100-(+&1($,,%&+%'**--#)10*,/0/0%(&.'/,+&''$/--.,$-$*+11+*%/+0&%)(+(+%-,%(+/0,$*/'',(),#"$%)-*),%+--//-&1+-+).)/-$*/.)).-%)0/2//%(++$+'+.&+,.-*+,.'$-%.*()/*,/&/-&,*&*+%+//(/'.1-,+,*-,-(#&-#+,.)+,-,,')*,(*)*$101+/(("&*.*0-),,&#'**%.*',),*020/0(/*1+/,/.$,,+((%($((%&0&0)--&*0&+.0.-+/--,*'0.0+1&.'+(+(/)&'),$)(*)%(&&,&*$*-+-2/,+,01)1,'#!"'*/,*0-00.1*'%,.+,10-/,/,(),,+0$,*///%.*'0,(,*(0+*,/.+.),1$%&/)+,%&20..+0,2-,1,0./..$#0&3521*45046.63,3 @rCer/875/1320_49_CCS CCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + 5-/./6580EGEA>DFH>D=GH3C=?/8HHE3AA8E?@@E89A8FD<=AFG7DA;;88D=;:1?:C:GA@ECC<<9@BG5DGCAG>DCIADAB=C<988G>58?=FDE/F?AECGI?HB=CH?*D;EH3;;=GIH>:JEIFF4EF@CC18F@FIA29?D=9IHHFFI@B>CB?IHE>>EC?<@;8;89D7DEIID9J@D>BIH;IEIHFFEF7H?HDG?=DHG8C+?EIA:EDH;BIF@>H.CGEDHG1IA@JGHIH4FFIHJ8C>@A4DE1JEEIAH?$@GJKHHHKEKIC>KJG>IC<25=@BAD:79EE#A@CEFED>/BEDJH=GBIDFIGICFI?IAGEF<@AI@E>AA?CDCDF=EH=AA:9?8>D:CE4AA@:CHCCF73<=HHIIKJF>I8JFD3A@HC<51=GF2FEHGF@;GH9CFCIEEF?KF=IGFECHCG1GHJJKG99GJGFFJJE9?C87?9E>EHHHHB?;@ICDIJ:DKHCG=FJKA@IDF@589+BDFFAIHEGHGC>BEBEB7H?IJBHCI?B6?A>>>=?@B@C@?D@C,FBEBBD:?GB?7DGC @rCer/879/0_451_CCS ATCCACTGTCTGCCAGCCTTCCTTCCCTCCCACCTTTTTGTTACATTGGTGTAAAAAATGTAAAACAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGGAGACTCGCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGCCGCCGACAGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTTGTAAAGCTTAAGAAAAAAAATCTACATCTTTATACTTGAGCCTCCATACTTAAAAAAAAAAAAAAAAGAAAAAAATTAAT + S0'18:7::7768;:669301949)98736?6;=2><<<9>?7)99?:=;9<-=<=;;;=7.<:::&979<75=9:5::3;;63:;:>9;?<9349=4?;356::/98+<:=<=7=84=?>>98=6?7;457;;;=5==3?=6=58;8284?8=6=+697<9885*98845:-:::9=;70397(:84959;876:9:*872;:?;;7?:;7==:;;>67;>79;+98;<9==::55;6=*3+$-93362=<<<:8*9;=;79;3<6+:;7:8<8:4=6/9:6>:=;?=>>8::79*89<996984>6==;;8:=;2<9;:$88&)<;8;*:8===9???9.<>>2%32646879=:=>>9<;:?:&6::934;;>97<8>8%0/516;:?>23265:=>9/<6:(<=>>>>><<<=959:6):===<3-<3>: @rCer/881/2702_76_CCS CAGTAAAGCGAATGCGGAAGCCGGGGTCGGCCTCCAGTTTGCCCGCGCATGGAAGGCGGTGAGGGGATTAAAAACACTCAGATGGCAGATCACAGTTTTTTCAGATGGGTGGTTCCTTAGATTCCGTGGGGAAGTTGCTTAAAAAATGCATAGTAATTACAGGAAATAGCTCACAGATCTGCGTGATGCAGAATCCTCGAGTTTCGGCAGCTTTTACAGGAGCGGACTTTGACAGTGTCCCCCACACCCCTTGTCCAGCTACATCGAAACTTTTACCTTAAAATGCAGTAAAAAGAAGAGTATTAATGGCATTGACAACGTTTCAGGTGAAGATTGTGCTCACATAGGAAGCAAGTTCCTATGAAGAGGTACATGGACCTGTGGAAGAAAGTATGCATGCACGTATTACCAGCCTCTTTGTTAGAGCAAGAGAAGAGAATTTATCACCCGGTTGATGTTGAACCAACAGTATTGCTGCGAATTCGGAATTGCACAGTGAAATGAAGAGGAAGAGGAAATTGGCTGTGAGACATGAAAATAAAGTAGTCATAACAGAAAAAGATAGCTAAGACGCCTGAAGAGCACCAAATTCCCAAAGGGAATTCCAGAAGTTCTTGGGTTTTACCATCTTTGAAATGTTAGATCTTGTCTAGTGATATTAGTCCAGGGAATTGATTGAACCATCTTGAAACACGCTGGCAGGAATTATAAGTGAAGTTTTCTGACCCTGGACAGCCTGGATGTCTTTTGTGTAGAGTTTCCACTTATGTAACCAACGAGTCTTACTTTACCAACTCATTAGTACCTGACAAAACCTACAAGATGAAATCAGAACCAGATAAGGTCTGATCCTTTTTCCTTTTTGAAGGTCCTGAGATTGTGGATGTGACGGGGTGTGTGTACCATTGACTGAAGAAAGGAAGAATGTTACTGGTCCAAAACCGATCAGAAAAAGCAGAATGCATAAGCGGTCGAGGCGACTGTTTTAGTAACAATTGACGAAACCAAGTAGCCCAATTGCGAGTCCTTTTTTCACTCTTCCAATCCACTGAAAGCATCCGGGGATGTGAGAATCACTGGTATGAGATTTTTGCTTGAATTCATCATTAGCCTGCTTGATATTGTAACTTGTGAGCATCTTTTTTCCTGGTGAGCGGTTAGTCCCGCGGGCTTGGTCTTGCTGTTTGACTTACGACTGGGGAGGCCATAGAGTGATGATGACAATTTGAAGGAAGGTGAAGAGAGAAAGAGGAGGAATTATGAAGGTGACGAGGAGGGAGGAAGGAGAGGATGTAGCAGAATTAACCCCAAGAAGGAACCCAGCCAGCCGGCGGTGAATGCAAGCGAGCAGTAGGGAAGCGGGGGCGTGGTGCCTGCGACGGACTGTGTCGGGACTCCAGGCCTGTGGGGCGGTTGGCCCCGCCCGGTCCTTGCGGGCAGCACAATCCCGTCGGACAGAGCTTTACGTCCATCTGAACTTCGTTTTCAAGGCATGATTTTTCACTTCACTTTTCTCTTTTTCTTATTATTTTGGCTTAACTTGTGACAGTGGCAACTGAATGCATTCAGAATAGGTGGTTTCGATCCAGCGCCCTTCTGCAGCCTTTGGGTGCCTGGTAGTCTGCTGGGACTTGCCTGGGCACTGTGGGAGTGGGCCATAGAGTCAATCGGGTGTGGGGGGGGTACTTGGCAAAGTGGCCGATGGGTCTGATGTGGTTTCCAGGATCTAGACCTCTCCCGCGCCTCCTGCAGTTGGACTGATTCTGTCCGCTTTATTTCGTAAGAACCCATTGCGTTGTCTTCAGCTTGTAATCTGCGAGTGTGCAGCCTTGGTCACCTGTTACTATGCTAATCATCTCAGAAGGGCTTGCTGTGAGAGTAGCTGTTAGTTCTTCTTAGGATGGTTTGCTTCTTCGATTTTTCTTTTTTTTTAATGGGGTGGGTCAGGGTTTGTGACACACCAGCCAAGGCAAGACGCTTGCTGCGGAGTCACCTTCTATTTATTTATCCCTTCTTCGCCTTGTGAGGAACTGCGGCCTTGCGGCTGTCACTCGTCCTTTACCATTTACTGGAACACCTTGTGTGCACTGCTGTCGGTGAAGGATGGTGCCACTTACTAGCAGGAGCAAGGCCTTGGCAGAAGATAACGCTTGCTCCTTGCTCACCAGGGCATGAAGACGTCGATGCCCGTCTTCGTGAACGCAGTGCGGCCGCCCTGGCTGCCGGGTAGCCGGGCGTTCCGGCGGGTCTTCTTTTCTGTGAAGGGGCTGGGCTTGGGGAAGTCCTGCGTCGTTTCAGTTGAGCGTGAATGAGCGTCTCAAGGTTCCGTGCTTTCTCAGTAGCTCCCATTTGCTGGGCCCCACCATTCATTTCCTTGTCTGCAAGGTCCTGGGTTTGGTGTGGACCGAGTTGGGGATGGGTGTGGTGGGATTTTCCATAGTGGGGACAGGCACTCTCCAGCAGCTGGGATTGGCCGTGTCCACACGACCAGGCCTTTGGAGACGTGCTTCAGCCGTTAACCTTGGAACACAATTTGTAATCTGAAGAACAGTGTTTTTCAATTCTAGTTACAGCAATAGTTTAGGAATTGATTCTATTAAAGTTTGTGAAACATTTGGAGTCAAAT + 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@rCer/884/25_1655_CCS ATGGGAGAAGGAAGATGGCGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGTGCGTATAGCAGCAAAATTCATCATTCATGCCCTCCTGGAGAATTTAATGAGGTTTTTAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAAAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGAAAGGAGGCAACTGATCAAGACCTGTGAAGTAGAAAATGCAGTTGAATCGTGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTATGTAAAAGAACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATATATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCAAGCAAAAAACTTTTGGAATGGTCGTTGAGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAGGTGGTTGGCATCTTGAAAATTCAGGTTCATTATTATGAAGATGGTAATGTTCAGCTAGTGAGTCATAAAGATATACAAGATTCCTAACAGTGTCTAATGAAGTGCAAACAGCGAAAGAATTTATAAAGATTGTAGAAGCTGCAGAAAATGAATACCAGACTGCCATCAGTGAGAATTATCAGACAATGTCGACACTACTTTCAAAGCCTTACGTCGACAGTTGCCATTACACGCACTAAGATTGATTGGAACAAGATCCTTAGCTACAAGATTGGCAAAGAGATGCAGAATGCATAAGATGAACATTGCATGACCGGATCATTTTAGTGTCTTTGCGTTAAAAAATTATTGCAAAAGTATTCTGAACTGTCAAGCTGCCAGTCAGATGGCTGTTGCCATTTAAAATCACTGTAATTAATTAGTTTGATTAGAGCACAAAGCTTAGCTAATCAACCATTATTTTTCATTTGTTTGTTCTAAGAGGATTGAAAATCAGTTTAGTTTAAATGTCTTTCTGTTAGCCTTTCTTTCTTAACAATGAAGAAGAGATGATTCTTCTAGTTTATGGTTAAAAGTTTTTGAAGTGTCTCAAAATATTTTACTAACTGTAACCCTAAAATTGTTGTCTTTTGGTTTATGAAATGGTAATTTTTGATATTCCCCAGTTCTTTTTAATGGGTCAATAATGACATTCTAGTTTAAGGTGGTTGATGGATTTAGCCATATATGCTGCTAAGAAATTGTCTACCTTTTCTTCCTCACCTGTTCCATTTATGTAAGTTGAGATTAGAGGAAAGCATTTTCTATATCAATTGTGTTTAAACTTTCAAGAAGGTTATTTAGCTAGCTTAGTGTTGAACTAAATTTTTTTAAACAAGGCGAGTCTAATGCTGTTTTGAGATTCTGAAATTAAATGAAAATACTTATTTCAGAAATGCATTTAATGCTTTTTTCTTGTGACAGTTACGCAAATCAGCTTGAATTCCATATGTCCTGAGTTATTTTTATCATAAAGCCACAAATGTATTATAACAAGGCAAATTGTAATATATATAATCCTTAACT + @I2DI8'-K/J7KHJG7I&CKJCG>JF6IGGKKGGKKEGKKHKH7K)HEFI+BHCK>BACCKEE@.KIKEIHKIG@JKIHF:0KK>&EKJKJJ>K4KKIKKKH.K+KKKB@KJKJBFHKE;KIKI9JKI?B9GJJKEBHBHKI2HKFKE<2K9KGKJEKKIKJ>IKIJHK?KKD7KKKK.FB:)?HKKKAKAFKIKKEKK2KKKBKK+JIIGJ;DGEK1KI;JK5KK(GH:KIJKKB#(6JKJBKKKKKF-5KH$EJJKK=KKHKB<'KKDHJKKK=:DKAHKJKKK+KDDIK?KIK4IKKEBJABKKKKKKKJKKIK6JJJHKJKKDK>JB;(KJCJJKG:JKKKKKJ+A7KKJJKKKJJKK1KG*KI$KKKKKBII3KAK=;:DKJ;K&K.KA)K%@K-IJKKJHBJK3KEH;K*KKAKK5J5KK9KKI:KKJ@JKBKDHKK4KKIKKKKKHEK1K;KJKJKDKKKKKKKJK+KKKKKGJ$KKKKGAKKFKKD:KKKJJJDKKKJ8KKKKKKDK>IIB0JK7KKGJJK&KIJFGKJ-FD2KIJKKKKKKKKKKJKEK>KKKKKFKKKIJKKJKKEKBAKKKFJKKKIKKKKEEK+KJFKK&KKKKKH$KK.2HK8GK+FFK>K*KKFKKDKKKJKKGBKKKJ8KK:KKJKIKCKKKKKDKH0KBIKIJKKKKKJE)KKK6K7KKIKK;KKG(KIKK7KKKK;IKJ'K+EKKJJ;K2-KKKKKKK6KKJJDKEIKI'IEIJKKKKK(K?KKKJ3KJKKBKJI2KKKKJKJKG)DKK2KJ>5KKHJF/9>HJ;A>KIK @rCer/885/25_1969_CCS ATGGGGGCACTCGAATATACCCACGGACAGTGCTGCGCGGCTTTTCTGAGTGTTACGGCACCCTCCTGCCGCCCGCGCGGCTCTCGGGCGGGGACCCACCGGTTTTGCTCCGCTTTAGCAGCGGCGAAGGGAGGACCCCCGCGAGCCGGTCCCTGGCGTCCGGTTGCCCAGCCCTTTTCAGGCTTGGGCCCGCATGGAGGGAACCGTGGAGTCCCAGACGCCTGACCTGCGGGATGTGGAGGGTAAGGTGGGCAGGAAGACCCCTGAAGGGCTGCTCCGTGGGCTGCGAGGCGAGTGTGACCTAGGAACCTCTGGCGCCCTGCTGCTCCCAGGGACGCCTAGCACCGGCCACGACTTGGGGGACAAGATCATGGCGCTGAAGATGGAGCTGGCTTACCTGCGAGCCATCGATGTGAAGATCCTGCAGCAGCTGATGACCTTGAATGAGGGCATCGAAGCAGTGCGCTGGCTGTTAGAGGAGCGGGGCACGTTGACCAGTCATTGCAGCAGCCTCACCAGCAGTCAATATAGCCTGACAGGCGGGAGCCCAGGCCGCTCAAGGCGAGGCAGCTGGGACAGCCTGCCAGACACCAGCACCACAGACCGGCTGGACAGTGTCTCTATTGGCAGCTACCTGGACACAGTGGCCCCCAGCGAGCTGGATGAACAGGGCCCACCTGGGGTTCCACGTTCCGAGATGGACTGGGCAAAAGTTATAGCTGGTGGAGAGAGGGCCAGGACTGAGGTGGATGCGACAGCCACCAGGCTAGGGAGCTTGAGGGCTGTGTGGAAGCCCCCAGGGGAGAGGCTTCAAGGTGGACCACCTGAGTCACCAGAGGATGAGAGTGCCAAGCTGGGCTTCGAGGCCCACTGGTTCTGGGAGCAGTGCCAGGATGATGTGACCTTCTTGTAACAACTTTTCCACCCTTTTGTAATCCTGTGGCTCTTTTATCTGTTAGCTGTGGTCTCCCCTAAAATTGATTCTCCCTCAGTCTGAGACTAGGAAGAGGCTGCACTGAAATCAGTTACCATAGAAACCTGGCTCATTTCTCTGGTCCCTAGGGAGTCTCTGCCTTTATCCGTCAATTATTGGGTCCCTAGAGCTAGCTTGCTTGCTCTTTCTTTCTTTCTTCCTTTCTTCTTTCTTTTTTTTTTCTTTTTTTGGGACAGGGTCTTATGCTGTCACCCAAGCTGGAGAGCATTGGCATGATCACAGCTCACTGCAGCCTTGACCTCCTGGGCTCAAGCAATCCTCCTATCTCAGCCTCCCCCATAGTTAGGACCACAGGCATCCACCACCATGCCCGGCTAATTCAAAAAAATTTTTTTGTAGAGATAGGGTTTCCCTGTGTTGCCCAGGCTGGTCTCAAACTCATGGGCTCAAGGGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTGTGCCCAGCCCCTAGAGATATTTCTACAGAGATATTGACTCTAAAGGATTGACCTATGGCTTTTGGTGTGAAGTATCTCTCACTGCTCGCCCCAGCTAAGTAAGGGTTTAAGGAATTTAGGACTCCCTGGAGTTAACAGATGAAGAGATGGGGGTATAATTACTTCACCCAAAGTCTAGAAGCCTTGACCCTTCTCTTGGCCAAGATGGAGGATTGAGGAGGGACATGGACCTTCAGGACTAACCCTCTATGGATTGGCCCTCCCAGAAGCGTTTGGGCTGGTAGACCCACCCCTTCCTACCTGCTGAGTGATGTCATTTCCTGCCAGGATGGGTAGTCGTTTGTACGGGTCCTTGGATGGTGGTAGGTCATATAGGGGTATCTGAGCCCCTGCTGCTAAGTGAGATCATATTATTTATCGTCCATGCCATTACTTCTTGTGAACAGGAACATGTCACCCCTCCTGGCAGGAAAGCTGCTCATTGTCATGTTTGTGCTTCTTTTCAGAAGGTTCTTACTTTT + 8F?KIKKIHKJKK@K;GKKKF=GKKKGKJK*JKKKJKKKKKKKKKIJFKKKKKKHKFGKKKJIDIKKKJKKCJK@IKKJKKKJKKKKFKKK5KKJKKKJ:KKKHFKJCKIBEKGKHKIKJ8JDK.AJJIDJIKKGKKKJCJKJHJK@KKKJCKKKKHKKI=KKKKKJKKKKKKKIJKKKKJKHKKKKEKHKKBJKKGCEJJHKK@KKKKGHKKK@KKKGJJKKKKHJK:KKKKKKKKKK?KKJKKKKKKGKKKKEKIGJKEFKGID=KI@KKKBKKKKKKKCAEKKKKKGEEKCKKKCKKKKKKKKKK;KDKJHKKKKKFKHKKKKKHKKKK4KKFKJJIKKKKJJHKFKJKKKKKKKKAKIFJKKKKKKIKKKHKBIJJKHGKKKJKKKGKJKKFKKHJKKKJKKJKKKKKJK'KHJJJKKKKKKJJKGJHKKK@KHKKKKBKJKKKKKJKK9IIJKKI0JKKH??FIJJJGKKKJKKKKKF:JKIKKHKJJHKIIJIIJDFI@D3JKK>GBGJGDKKJKHKIBFK>KHF;IKCJHHJ=IKKKK>KGJJG8KKCF>KKKKJKKGKKJIKKKJKFGGIKIJKJ>DK6HDJIKKK@HJGEKJKIKJKKIKKKKKKKJ?IFKKJJJJKIJK4DEKJIHEJCIJKI>KJHKJGKKKKHKGKIEIKDIEKKKKFJKDJIJKJ?KD;KIKKIHKJJKKKKKEKBFJBKKGK=GHKKGK:JJKFKIHFKKKKKIJI?K=FCBKKKFJKKKBKKKHKKKDKKKKKKKJKK@KKK$KKKKKKIAD>,@IKKKI8FKKIF=CGIFJKKKKJJKKIFIKKKKKKJEKIGJJJFGK@KKG@KKJHKKKIIGKJKKKKJKKKKKKKEKKKKK&DIJJJHKKKJKKHD?FDJJIJKJI1JKK-KKKE=+GIDKKEKDCIJKJHKJKJ@GAG=GFGGIIAJJJKHKAKHKJ7HJKKKH2EFKKKDI>EKGI=EBFKKBKKJKKKJKJFGJFKKKJKIGIKDKGK>KKKGJJ?>JI:KGKKKFBIJED@I7FEKKHFKK1DI@KIKJJKD:KKIFJIJI)KIJJBKKKKFKKKJJKKKKKKKJDKGIKJFIJKKKKKKJJKKKFKKKJJKJGJKKJGKKCBGAEJFAIIKKKKKKFJDKHDFBJIKFKFBKJ0KKJJKIKKHFEJG:JJ>KDAJKKK74;9)965;34:<83,)6693:946293-80>>;;47:489,=8>>75,>74+2:778>9>>8>::::<=;67960,4.488>?48=<5*674-05:1:;76:-046;5;2)/7/-40415677.9:?=<:?469>@BA?46>9;986=:89=B@/681*5(6A@A:>2B>;BCA=5:6>09==7<564?9<.:40::79:<:+/5%56/.53/0-.2+$(#)4451-54<.25:9237321/)8:::2/969?;;9575595$,*2407270'826,127588;4&&-231&212,75=8758381811:9912)714/10,52(.5/%1,-./6&5,/2961+/.000.4<610'0+02-(.'3/-&$2*)%&79<358<=<>6=>7276&4.5>>:-7/50:8017+665655947>;8=53321768=61+466)94%733.9:<1&856318226(.2709403.,-,4929>702.0+328226<89.,.*782(+::8;49469+31-,+,56;>7<=5:)43?4:748956445610306/97281,/1.403704<083/)-.67303101/48:+?=48<1.9.<1669/5:579:>9773485724)1<33$(3022;<615963.;7-3(1'246*;354--4./1(:310<-68<7;=;598/8.5.20**856134+++1/1.64-33,++-/1-&-1-427(1443-140-&2+,1685:9:29336/%&,1,7:/630+30041+3,/089438347(5381,86/94::;62814446%/533(/.-175:937-7:91/8/494766:769317*395-+6471.508344-2032053977673-535:55092788)4;42647+54+-4--+2)43738**(*$#-/0269:63681089344-,&283,7-264-645:7651-.+--(//'+*(11(+311834473547013716*'+*4800.2+/69542186363:46897/955:2.3.14/)120//%55+,30*'))-.13,72/4/854322142446+59589::5:62,00-)04/542.%0$3,/))&/.1/(24609+,6-(2--504.21''/12/**(2983/.-%(,0&+)*)%1.4-00/41/:64,7338+95.300&&3241#0)03/6/:5/862523*29482045:84/*'50&+/%50./-'3-1-/62,541/2'3/%00221+141368758931*22+12(8-321851061070355.276'.4923323/.241+)/++,,-)*511734605468;57::7479935877-90-*32.66/1&)/-,*5.('6;.64429880597.9655226/022//5-5.59/%9%/*78635543/)),54241-&/1/864:3.*.2/+44169:,6:351,.31-93/*/,445634-,+2-311..3330.,0531-).0213*2*0/2./40/,140/0.122845&332234.%5742:133741390/'/3.526482+.)1-2590.2.451:8433*0.4762174)202:./441*771'(-))-'#443(/213978+/..5/%-$%7021'160335741*(95.,4543('&2-+5*12/5;.,;:3/787::?;937=:)3').2/(5985:6791'/0+1),105.8:7:7247434:665362-,/.5/98:610-3278166:5.00,:966/61991+4995647.60.58.0,)1:2746)331:451.965356/'0-2/1$6:5798364112+#,.:147.438:44514/,1&/831/2,12/2++11/375+3/-/6,78+,/82%+'(&42807/778456956556568306743843-33;8643&2,$")).5/2946*536267+23063+34.-03242//.%*32*&,-25+5(%*)(*8:295:041./47220-073%9:43865/')%1&4%.'23+%7,2197/8974.2547)3/')*61**61322+24218-+0*11-/)042367.1(10+*14)752./0-7.9662422'./..6444--(/10&74+(-,))/4-7-2,)48:631100153/021&58642621(2('*6385/35--..)%/)2,10,*,1-83179743/+-.65/4.40/(15):54).+6349,94831+32876)14.38.98966123'3+22,853+-(#,*%*),2/2.2+234/-.9162794751.,%,)(.449755284+*474632,,5*542/'0601(241*17458:41/03+357-4.3265856;6510-%656.4826/32641-489-1,-4,,-+-69926460,..(0705./6/&02+344:54-+4/,-21*.51/$-,://37552.5232214-0'%933*224+,,07281671641)28)5556):975.4633)(/3.:5:50020571/::735946454436:6+69465995/7.18668;5:-476-97+1918978/05386747.(1594+83:22563354.370363892;99524669,+(44:4-77 @rCer/890/1859_54_CCS ATGGGCAGGGTGTGTAACTTTTGCCATCTGTATGAGGATGATAAAACTTCCATGTGGTCCTTCAGCTGTGGTGAGGATTCTGTGAGGTGGAAGGTGAAGAGCACGCTGCATTCTGTGCCTGATGTGGACTGTGTACCCAATGGAGGAGGGATATCATCATCTCAAACCATGCCCCATCCCATTTTACAGGTGAGGAAACTGGAACATAGAGAGGACCAGTTCCTCTGAGGTCAGCCAGCAAGTGCATGGCAGAATCAAGACTCAAATTGGGAGTTGTCTGCTCCCTCAGCCCAGGACTTTCGTTGAAAGCCTCTGAGTCACCAGGGGCATTGATGACCTCTCTGCGTGTCTCAAGCAACCCACAAGGACTGTTTTTCAGCTTATAGTTGAGAAGACCACCAGCCTGGACAACACGGCAAAACACCATCTCTACAAAACAAAAAGAAAATAGCCACACGTGGTGGAGCACACTCGTCCCAGCTACTCAGGAAGCTGAGGTGGGAGGATTGCTTGAGCCTGGAGTTCAAGGCTGCAGCGGCAAGTCGTGATCATGCCATTGTACTCCAACCTGGGTAACAGAGCGAGACTGTCTCAAAACAAACAAAAAACAAGGCTCAGTAGGACAAGTCACTTCCCTGTGTAGAGGGACAGGATTTCAACCCAGGTTGTTCAATGCCACATGCTTGCTCTGACTCTTCCATCCACACCGTCAGATTACAGCCAAGCACTGACAGCAAACTCCCAAATGAAAGTACATTGGTAGAATCCAGTATCCCCACTCTGGAGTGAGCCCTTCCCTCATAGGGAAAGAGAGGCAAAAATAAGACTCATACAGAGAATAATTTCATGTTCTGATGCTTTAAAGAAGACAAGGTGGTATAATGGGGGTGACAGTGAGCTACAGGGTGAAATATTAAGGACAATGGCAAGCCACTTAAGCCAGCATGGTCAGGGGAAGGCTGAAACCATTCCTAAAAACTTTATAATATTAATCAGAGAAGAAGGGAGGGGGAGAAACTAAAATCAGCCATACTTACAACACACTCAACATTCATCATTAGGTCAGTTTGCTCTCTGACCCCTTCCTCATAGCTAGCTGTCTGCCTATTGCCCCAGAATCACACACACAAAAAAAACCCAGTCACAGATATAGTTCCCCTTAACTGTTCTACAGATAACATATTAAGCATTGTGAAAGGTTAAGTTTTCCATTTGAGATATCTTTTCAAGTCCTGCATACCAGTGAAACTACTGATGCCCACTGATCTGAAGGACCCCACAGGAGCTGAATTACCAAAGAATGCAGCTTCCACATCCAGATGATTTCATCCCCCTTACCCGAACCAATCAATGACTCTAATTTTCCAGCCCTTCACCCCCAAAGATCCCCTTAAAACCCCAGCCCAGAATTCCTCAAAGAGAGATTTGAGGGTTCTTTCCATCTCAGTTGGCTTCCCTGCAAGGGAATTTAATTTCCTTTTTTATTTTATTTTTGTTGTTTGATTTTTTGTTTTTGAGACAGGGTCTCCATTGCTTAGGCTGGAGTGCAGTGGCATGATCGTGGCTCACTGCAGCCTTGACCTCCCCGGGCTCAAGTGATTCTCTCAGCCTCCTGAGTAGCTGGGCACATGCCACCATATCCAGCTAATTTTTGTATTTTTTTGTAGAAATAGTATTTCACCATGTTGCCCAGGTTGGTCTCAAACTCCTGGGCTCAAGCAGTCTGCCCACCTCAGCCTCCCAAAGTGTTGGGATTACATGTGTGAGTCACTGTGCCTGGCCATAATTAAACTCTGTCTTTGCTG + =<>>/<29=/64--19.7;?97==3947;33::9>?749<99984%59/2*:<;7?:;596<569=88<<;7<2:3<<18699=79,?==7:36026:53*1:4,<:81936;.282239<889=:6=47??3?64><<=//<;6/<-<:6:89992-963>9:=:??:39:<3$3:;;.69:9.9458+69(66;5?489=62:35?5<:,:8;9?8;;><3:;;:76;;:98=0899925<9;:984:;=6<7::;:9,98??:517'54,3:24<=28312=>0<<581;9&346=<8==<=09=>=.;>>6=75=<2.77279:4><992><<.436-61$36;57-45688755+6984406::6972434$47;998,3361/99543(,26603697/77;7677653)/599(9:::8.651/(4-77'12438*7/.2.3//12,003:::508665/6::96-.-3018793332%25,35.35:5::6:0.9%12418;7967718-99:.48,5039876:95186+.8321*5):3859467621744:6:84:458:79639:::916:94736774&8;561365421,7769;463324:27:44/'2/69347(6564.245257+7:165(7,5:0891994-//(,+45,57596955256*8/9:732325/8784/77.34439,5(.4947888,7268)4345*::71389/442.(4/:5/..4%87/89567565)4386/:-6959:5:92:9::,78,/2;;8:9296889677775'7956(0..9880(//./+57369+32:995945256366&28248-4366/3/31+-0+2+,4656&87597628505863.44,449944284;4:28:71-636996983400,%8:4481.79:669678&96958089;396:674511465%770&.34..6:5647:58885.734::123.23%6-;:336774$96.8;98,5/7)99:0:8:06508,539276.049214,25)8::286:9739::95985:72.3566592753947368;58/;97977%+07-9614828222/266766$77899:::3$28868:84341-)0/:25/6723,(-*332566.7-8+-,4532/5.697/917.524545%73135'5:837848987.83-88653905277/3655:92332556545:808116447,467765;6;7487;5*2699713394-69-9;738:757985183448,7529659;5%4.7675'94762+68.:452855-64294+792755):7::77-830544/5%:8,655:98/7.7::+678.1799789:/8-;24:;95559:7897)3.49,,(046)6047:643896;878425*844:447'939;6:6:6.-046777&(878'37887'786752$3587467'56::9+554-3049(220730999350661578.96134.3021,.-452:::;89659::788585:4553-4389):9695251.5:997:8768:681785272-3:8979:52479639,69-22347-65450)4478$553434676'6859:9183:631;5:<<,==:=28::(5=:95:19==<=9+55:7>;;23=::*<>;5.752>86>;;5896?:><=68:*;<=;+9=0<:'45934:4985+964;3<78:49;88-303+>6==47;;;>;=:=,9871 @rCer/892/25_2140_CCS ATGGGGAGAAGAATATGGCCGCCGGGTGTGGTGAGGGCGACGCGCTTGCAGTCGCCGTCTCTTGCTTTCCCGTCCTCTGACATCGCCTGCAGCCGAGTGGGCCCGTCCGCCGCAGCCGAGGACCAGGTTGGGAGACGGTATTCAAATAAAGTTAACTGCAGCTTTCTGTGAAAAATGTCAGTTTTGATATCACAGAGCGTAATAAATTATGTAGAGGAAGAAAACATTCCTGCTCTGAAAGCTCTTCTTGAAAAATGCAAAGACGTAGATGAGAGAAATGAGTGTGGCCAGACTCCACTGATGATAGCTGCTGAACAAGGCAATCTGGAATAGTGAAGGAATTAATTAAGAATGGAGCTAACTGCAATCTGGAAGATTTGGATAATTGGACAGCACTTATATCCGCATCCAAAGAAGGCATATACACATCGTAGAGGAACTGCTGAAATGTGGGGTTAACCTGGAGCACCGTGATATGGGAGGATGGACAGCTCTCATGTGGGCATGTTACAAAGGCCGTACTGACGTAGTAGATTTGCTTCTTTCTCATGGTGCCAATCCAAGTGTCACTGGTCTGTACAGTGTTTACCCCATCATTTGGGCAGCAGGGAGAGGACATGCAGATATAGTGCATCTTTTTACTGCAAAAGGTGCCAAAGTCAACTGCTCTGATAAGTATGGAACCACCCCTTTAGTTTGGGCTGCACGAAAGGGTCATTTGGAATGTGTGAAACATTTACTGGCCATGGGAGCTGATGTGGATCAAGAAGGAGCTAATTCAATGACCGCACTGATTGTTGGCAGTGAAAGGAGGCTACACACAGTCAGTAAAAGAAATTTGAAGAGGAATCCAAATGTAAACTTAACAGATAAAGACGGAAATACAGCTTTGATGATTGCATCAAAGGAGGGACATACGGAGATTGTGCAGGATCTGCTAGATGCTGGAACATATGTGAACATACCTGACAGGAGTGGGGATACTGTATTGATTGGCGCTGTCAGAGGTGGTCATGTTGAAATTGTTCGAGCGCTTCTCCAAAAATACGCTGATATAGACATTAGAGACAGGACAATAAAACTGCTTTGTATTGGGCTGTTGAGAAAGGAAATGCAACAATGGTGAGAGATATCTTACAGTGCAATCCTGACACTGAAATAGCACCAAGGATGGTGAGACGCCACTTATAAAGGCTACCAAGATGAGAAATATTGAAGTGGTGGAGCTGCTACTAGATAAAGGCGCGAAAGTGTCTGCTGTAGATAAGAAAGGAGACACTCCCTTGCATATTGCTATTCGTGGAAGGAGCCGGAAACTGGCAGAACTGCTTTTAAGAAATCCCAAAGATGGGCGATTACTTTATAGGCCCAACAAAGCAGGCGAGACTCCTTACAATATTGACTGTAGCCATCAGAAGAGTATTTTAACTCAAATATTTGGAGCCAGACACTTGTCTCCTACTGAAACAGATGGTGACATGCTTGGGTATGATTTATATAGCAGTGCCCTAGCAGATATTCTCAGTGAGCCGACCATGCAGCACCTATTTGTGTGGGGTTATATGCACAGTGGGAAGTGGGAAATCTTTCTTACTCAAGAAACTAGAAGATGAAATGAAAACCTTCGCCGGACAACAGATTGAGCCTCTCTTTCAGTTCTCGTGGCTCATAGTGTTTCTTACCCTGCTACTTTGTGGAGGGCTTGGTTTATTGTTTGCCTTCACGGTCCATCCGAATCTTGGAATAGCAGTGTCATTGAGCTTCTTGGCTCTCTTATATATATTCTTTATTGTCATTTACTTTGGTGGACGAAGAGAAGGAGAGAGTTGGAATTGGGCCTGGGTCCTCAGCACTAGATTGGCAAGACATATTGGATATTTGGAACTCCTCCTTAAATTGATGTTTGTGAATCCACCTGAGTTGCCAGAGCAGACTACTAAAGCTTACCTGTGAGGTTTTTGTTTACAGATTACAATAGACTGTCCAGTGTAGGTGGAGAAACTTCTCTGGCTGAAATGATTGCAACCCTCTCGGATGCTTGTGAAAGAGAGTTTGCTTTTGGCAACCAGGCTTTTTCGAGTATTCAAGACTGAAGATACTCAGGGTAAAAGAAAT + >>&<<2299;8.=4419>;?<2<*;31467?<4-+950898<>6;.:99290=<9:63+:=294::=?)9;>7'.34,::>>=875==979416=>>76;=,998#5=:59.>>536388=:999;>:?6;?:9<49;(148;,32-,59,6?5>37>;359'9<:<>,6%;4,69<9=;:+<==924>=>=:04702477<1/;87><6857;:192=83??>996;168;7/8<5'<96:8229<.;6+8;;88:>8>?=:;>9=<0=827388:9485<:;72<;:;7<;?<=859;1=+(7:;=::924:3.73*8955,4/855'88516136-9-454372135332297:566148&56./0%02,114449//35.,269432350.1'0)7-31+/::916,:36:382/6:87489..6+)686)637996523.56-45470)9952/83932299.5+629:658/473863.1*'+265487,9:51680(444,2)4*19&356.6587(360445*..3-/6)464',45768108:,675.459-70(+*'021.466893)5146726168$155/35290&:9)#52627%525,556163,6443-75:7.79/4/9,53.635%468929837755/&382/750776160126:1909:258-56551:9678.3177/37:1.1.3457-460095:669579137294:2.2.45-510235.3523*3+831419098+80,573046484-04:753.899/.4+#595,66385386676:63.4/7424605//23/'76-07/658761667/*6569%79/85749:779/62*984,559:38-273::967-25888884/*498:6:6:070585*-3757947,*)0.9:227-:936965544(96329:7/72,444,58654828235/8986'456981964::99877917/21/%98750886/,324233006/3//-*&+-2,,)1/55/753:782%6477.15,62-056905668;,5*521688;:4:203413216635861:::/76:3166.48:4825770985-$2:08570601*2..4-885,6581672021-0.0'**,0/44./2-31,0)1010,+.002422-2)*324*.00+,/.',.+,.(000040035./2-170359+,66/6/1728/5067598527:394257275740517.334./*+%011+).11/++-.,,,/13-22(111%.'%/*,,0%,-0)+/546..,-).34044155,./'20/.11232++'*)1.03522131291774;,;6:=79:?;39:81::;0;767(757747;2=;77:6/66:4/8=9/857*9<884?=963697:9;586372.<36=6/35;18<))4526:757:4<;:5;=<=13./;38<<=35;23?<69;,58759)5)45:-6./332+9895901;9:7;;486#1227-80;9-;=25/;<5192850/:73;?>=7<7?9:>:5:<9:2<><1<8929.314+//?3:4:3654<,:9==<-<;8:9+=:9.;>/=3:75:;949,;;9/426;77117466:=;:8?=*>;'2=:?2<>9>>:/;<<4;(41/4.63.;:/*481:977;3:.=61==.78<04/./78;98;83;3998<53,7*0./)22%+01=862:::148=9==*62*30%187849;5;4>7672/696+75;8=*8);937*)375169::7665657,+9&8;:=7=8734)90;69;(<<5;2;1.).5033>);79?<468,8<542(89:<;8<926.+6)8865299,145.720,9;99$5/49/.7578=(589561<8.8927-;:<*3+314236*$1/2,3535>6-::9+85+5<(6'.0?+8718926.4;863?688:85:&5-82638:44*;;3.1*54=0$(&72637+%1393/20,279;986.17)70-;8;99;,6938<,'6;&543%87632;:0 @rCer/895/2249_58_CCS CCTGTAAATCCCAGACTACTTGGGAGGCCAACTTGGGAGGATCGCTTGAAGCCAGGAGTTGGAAACCAGCCTGGCAACAAAGTGAAATCCCATCTCTAACAAATAAAAAAAAATAAGAAGAATAAATAAAAATCATTTTGGCTACTCTGTGGAAATGAATGAGGGGAAAGAGAGGAGGCAGTGAGCGGGCAGGGGGCTGCGTAGGCAGGGGGGCGGAGTGGGAGTGCATGGAATCATGTGTGAGAGTGGGTGCAGCTGTAGACAGCCCTCCCGCTGGTGCACCCAGGCCAGCGCACCATCGGGGTCATCACCAGCTGGACCTGATGGACGAGGGCACAGATGCCCGTGACGTGCTGGAGAACAAGCTGCTCCCCTGCGCAGAGGTAAGCAGGCCATGCCCCTCAACCACTCCCCAGCCCTTCCCCACCCCTCTCTTCCCCTTGAGGCTGGTTGCCCTGACCTTGATACTGTTCACAGGCTACATTGGGGTGGTGAACCGGAGCCAGAAGGACATTGATGGCAAGAAGGACATTACCGCTGCCTTGGCTGCTGAACGAAAGTTCTTCCTCTCCCATCCATCTTATCGCCACTTGCTGACCGTATGGCACGCCCTTACCTGCAGAAGGTCCACAATCAGCAACTGTACGAACCACATCCGGGACCACACTGCCGGGGCTGCGGAACAAGCTGCAGAGCCAGCTGCTGTCCATTGAGAAGGAGGTGGAGGAGTACAAGAACTTCCGCCCTGATGACCCGGCTCGCAAGACCAAGGCCCTGCTGCAAGATGGTCCAGCAGTTCGCCGTAGACTTTGAGAAGCGCATTGAGGGCTCAGGAGATCAGATCGACACCTATGAACTGTCAGGGGGAGCCGCATTAACCGAATCTTCCACGAGCGCTTCCCTTTGAGCTGGTCAAGATGGAGTTTGACGAGAAGGAACTTCGAAGGGAGATCAGCTATGCTATCAAGAAATTCCATGGCATTAGGCACGTATTGGGGCCTGGGAGGGGGGCTGAACTCCAGAAGCAGGGGTCTGGGACAGAGGCGCAGGGAGTGATGAAGTGGGCCTCCTCAGGAAGGACTGAGAGCTCTGTTCCCCAGTCCTCTCACCCCAACTTTTTTGGCTCCCTGCATGACAGGTTCCAGCTTGGGGCAGTGGACCCGGGCCACCCGCGCCTACTGCAACTTGCTGGGCCAACTGGGCACAGCCCAGGGCGCAGGTGGCCGGGGGGAAACACCTCTCTGGGGCTGGGCCATCCCAGGGTGAGATAGCTCCCCTAGTGCCACCCGGGTGACGGGGCAAAGATACCCAAACCACTAGGTAGGCCTGGGGTGGAGCATCTAAGTATGAAGCTGTGTCCTTTTATGACGCCGGGGACTTTGCAACCCTCCAGACCCTCCTGTATTCACATTAGCCCAGAGTCAATCCCATTCCACCCCACTGCCCTCCTTCTAGGCAACCTGTGGAGCAGGAAACAGGATTGGGAGGTGGAATCTGTTCCTCAAAAGCTTAGATCCCCTTCAGGGACCCAGATCTATGCTGTGTTCATCCAACAAATCCACTGGGCAGGAAAATTTAAAGCACCTACCCTCTGCCAGGCAGTGAACAAGACCCATGTCCCCTGCTCTCATGCAGGTTCATTTCCAAGATTTGGCAATGGAATTTTACTTCCTGATAACTGCACTGGCCAATTCACAGAAAAAAAGATCTCTTTCCTAGTCTTAAAACAAAGCACTCTATTCCTGGAAGGCTCTTATGGAGAACCCAGTTTGGCAATTTTCAAGCCATTTGTGGCCATAGAACCTTCTGTATGCAGAGACCCTTATGAGGAAGCAGAGACTTATATTATCAGATACTCAGTCCTCTCAACACCTTGTCTTGCCCCAAACAGCCTTCAATTGAAAACCTTTCATTAAGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCTGCCTCTACTAAAAATACAAAAAATGAGCCGGGCATGGTGGGCGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTGTGAACCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCTGTACTCCAGTCTGGGAACAAGAGCGAGCTCTGTCT + %"$"$$%%%%%%$%"""!"####"&%#'&(%$(%))(%)(*-*--.*,,((-,,,)-+-*,*+*&)),+(%)++--),,)((++..))+,(,,---**$++,((+*)**%()%)*%+*+'&)()%%/*),,&+,/00)%.*(*..*)'-/1*0-%*'()/+*00+'+0*-..,00*,'00/.)+-0201010220*+&0,,-,--1/,.(),,+(#%(-+/&-.11001.+0(0.-.-,,-.-+.-0/0.01./.00+%)-&,./22+0.,&,++,'+/-(+1.1+$,*/1-0*',%*,**+/().**(*.'#*+-2.,+((&.0-),--,--+/.0)-0(-*/),'.-0*&0((#$&$)%+&)%&&0..0+&$&/1*/'//01-0,,.*(%/%+%(/11+012-/,&,%.02,1-20,/01,/)-*++%,11-+),11,2,.,0++.1-0*,--',),0+.&0.,,0(%+(-1.-1,-./*,-,1/+''*(.,/*..0.&'*,0'0+-'/,,2/0-02*..'12/),---0-.2,1-.+-*.,0+)(+')+,$&&*,)12.-/,-,))%&,(-0/)%$''('**+##%*,(%,/,+/,111*-&*-+,--+,$*+,10-,,**0%.-'/*&%01(0+,))-&#**$)'0*,+,0.&/)(-$!'-,$+/+#()+%(),-0+/&/21111..'-1/-(010///&&%*-...0..1-./-2-,-)).))(,*/'(,0.-,&-0102-&-&'+---*&%'-1.*&()),%2*+00/))-/-.,'$*--*()'*,)--0,),(1-.*,.%),0)/.-/--1--)+)/,0/(1110./+,./0,1/+/--*..-,&(,211.%*+12+/1,0-0&,+-1-.)0%+.,1./&*,./+.'...1-1-)-1+.1011/0-121110/&,01/*0.*/0,0,201*1-.++2/0/,-/)&.),,/+(01-1.,2/,+'%&$,0/+.'--.)).)--+10-,*+/-%0,0.-,10,,/,(+1-,.,02-.,,'++%-/0$,*0'0.11..-,))-//-,*/000101/'&'/-(1-+,&010,*/,-+&/.10-110,11.0+01-,(1/.',,(/+',--20,+),,.#.+++2./++0.-*/1.2-.&,*011.-,0)%01.120-20/.),1*,/-'#%''),,-,&0+,)+-0*'*-(202+&0//*01/*,-0+0.)'(),,+&',-.-,,*+-#&+%/,,+#%'')(.0'.-('&,$/+0.'///%-,,/&),*,'+,,*.,1.11)'++).2,(--*-..%,2/--0-(,.1.+(2.0,.*.*%+)&.+12.0./.),10,+011,%)0.-,+((,/-/-2'*,*&+-)*,$'(.,*%,+12+0,1.-.)1).-)%).',0-,--**%**0.2*++')'/-('*/.-*.0--,&,*&&,/'01-100/*&'1*1*01/(*%/+*0//)%*..('/2*&,/)'.(+)*,(&,-,%,/-/(1**&)',11'1*/*.0.-02001-0)(-#-01*-/+.-(0+(,&,.*,&*,00--,/*+))('(()')%'%),)/0'.0+0++%-12-++)(%/--0-'*(&+#*.020'.,1/.-+"-100,(),(../'*,,.00-,0&*,00(202.-+1.*0*-/&(-'--*%+#,--)0,.,*','*-**0,,,00(1//'-)110101110+.(0.1.2//00*,/+/1-/--+,+-%01111.,0-&*%*.)/&**-0.2+,101110)+0+/0..$,-10+0),)10+*.,%++,/,0(+%,10,1+/-*%)((%'#'10-0,+,2,---)/00,0(+.,*$$),,$$*),..-1,/0-/0---&/2/--0.,#&&++-/0/1.+0-.0)-0(''+/,1+,.*-%(,01)2-,,'0+.,1,1/1,22..,.11,,)/1-0)02/,1/,$(/.(.,-,+,/))('0.-00,+2101211-/-*-/*,&++--,,+,-02/-*---)((*+-/+).0*.0+.*)+--&.%,,0+*1111102/1-)(-/0-.-'1/,/1+)($','*))$$#(('***'-&%#-%),'+*+1/)-,--),+&(,-(+'*'-)'&*)(&&)--,,%-,,-,)(%#'+*(&*&%#$(,)()-)*#+-)++'$#$((),().*-)++)(*#'&)'$#&%('##(*(,-+(+ @rCer/896/1665_57_CCS ATGGGGACCGCAGTAGCCGCCTCTGCCGCCGCGGAGCCTCCCGAACCTCCTCAGCCGCCCGGAGCCGCGCCCGGAGCCCGGCTATAGAGGCTGCAGTCGCAGCCGGGAGCCCGCAGCCCGCGCCCCGAGCCCGCCGCCGCCCTTCGAGGGCGTCCCAGGCCGCGCCATGGTGAAAGTGACGTTCAACTCCGCTCTGGCCCAGAAGGAAGCCAAGAAGGATGAGCCCAAGAGCGGCGAGGAGGCGCTTATCATCCCCCCCGACGCCGTCGCTGTGGACTGCAAGGACCCAGATGATGTGGTACCAGTTGGCCAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTGGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCGGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAGAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTTCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCGTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCGAGAAAAACATTATTGAGGAAAATTAATACCACAGCATAATCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAATCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCCAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGAGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTATCATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAAC + KKKKK0KKKIKKKKGKKKKKEKKKKKKKKJKKKEKKKJKKKKKKGKKKKKKKKKKFKKKKKJKKKKKKKKKFKIKJKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKDKKKKKK9KKKKK(KKHKK5KKK3KKKKJKK;KKKKKCKKEKKKKKKKKKKKKKKK=KKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKJKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKK&KKKKKKKKKKKKKKKKKKKKKKKKEKKK9KKKKKKIHKKJKJKKKKKKK:KKK)JKGKKKKKKKKKKKKKKKJKKJKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKJKKKKKKKKKKKHKKKKK)KKKKKKKKEKCKKKKKKKKKKKKKKJKKKKKJKFKKKKKKKKKKKKKAKKKKKJKKKKKKKKKKKKKKKKK1KKKKKKKKKKJKK9KKKKKKKKKKKKKJKKKKKEK>KKIKKKKJKKKKKKK6IKKKKKKKKKKKKKKKGKKKKKKKKJKKKIKKKKKKIKKKJKJKKHJKK@KKKKKKKKKKKKKDKKK>KJKKKKKKJKKKKKKKKJKKKKKKKKJKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKBKKKKJKKKKKKKKKJKKKCKKKKKKKIJKKKKKKKJKKJKKKKKKGIKKIKKKKKIKAKKKKKKKKIKKKKKKHKKJKKKKKIJJKKKJKKKKK>KKKKKKKJKKHK@KKKKKGKKKKKKEKKKKKKKKJKIHKKKIKKKKKKKKKJKIKKK:KKKKK1KKKKDK@KIKK;KKKKKJKKKKKIKIKKJKKDK:KKFKKKKKKKKIKKKKKKKKKKKKKKJGIKKKIK6JJJKJKKKKKKIKKK:K=K @rCer/897/25_2131_CCS ATGGGGAGAGCAGAGCCAGGGTAGGATGGAGAGGAGGAGCGCCACGCGCGGGAGGCGGCCAGTTACCAAGAGGCGCTGGCGCGGCTGGAGGAAGAGGGGCAGAGCCTCAAGGACGAGATGGCCCGCCACTTGCAGGAGTACCAGGAGCTGCTCAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAACCGGATCACCATTCCTGTGCAGACCTTCTCCAACCTGCAGATCCGAGAAACCAGCCTGGACACCAAGTCTGTGTCAGAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGATGGAGAGGTCATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGAGGCAGGACCCACCTGGTGGCCTCTGCCCCATCTCATGAGGAGCCCGAGCAGAAGCAGGATAGTTGCTCCGCCTCTGCTGGTGCATTTCCCCACACCTGAGCTCCCCGCCACCCCAGCTGCTCCCCTCCCTCCTCTATCCCTAGGCCAGCTTGCTGCCCTAGGCTCCGTCAGTATTAGGCCTGCCAGACGGCACCCACCCAGCACCCAGAAACTCCAACTAACAAGAAACTCACCCCCAAGGGGCAGTCTGGAGGGGCATAGCCAGCAGCTTGGGTTAGAATGAGGAGGAAGGAGAGAAGGGGAGGAGGGTGGGGGGGGACCTACTACATCGCCCTCCACATCCCTGATACCTGTTGTTATGGAAACTGTTGCCAGAGCTGGAGGTTCTCTCAGGGTATCTGGGAACTGTGCCTTTGAGTTTCCTCAGGCTGCTGGAGGAAAACTGAGACTCAGACAGGAAAGGGAAGGCCCCACAGACAAGGTATCTTTGGCCAGAGGCTTGTTTTGTTTTTTGGTTTTTATGAGGCGAGGTCTCCTATGCTGCCCAGGCTGACCTTGAACTCCTGGGCTCAAGCAGTCTTCCCACCTCAGCCTCCTGTGTAGCTGGGATTACAGGCTCGAGCCACCATGCCCAGCTCAGAGGGTTGCTCTTCTAGACTGACCCTGATCAGTCTAAGATGGGTGGGGATGTCCTGCCACATGGGGCAGTCACCTGCCCAGATCCCAGAGGGACCTCCTGAGTGATGACTCAAGTGTCTCAGTCCACCTGAGCTGCCATCCAGGGACCCTGTCTGTGGGCGTGCTGTGGGCAGGTGGGAGCTTGATTCTCAGCACTTGGGGGATCTGTCGTGTACGTGGAGAGGGATGGGGTGCTGGGAGGGATACAGGGGGGCTGCCTGGTCCCCAGTGGTGGGTACAGAGAGGTCAAGCCCAGGAGGACTGCCCCGTGCAGACTGGAAGGGATGCTGGTAGAGATGGTGGAGGAGGCAATTGGGATGGCGCTAGGCATCCAAGTAGGGGTTGTGGGTGACCAGTTGCACTTGGCCTCTGGGTTGTGGGAATTAAGGAAGTGACTTATCCTCTTGAAGATGCTGAAAAAGGAGAGAAAGGGGATGTATCCATGGGGGCAGGGCATGACTTTGTTCCAGTTCTAAAGGCCTCTTCCTTGCTGTGTCATCCCAGGCCACCCCAGCCTCTGAGCCCCTGGGACTGCTGCTTCTTGACCCCAGTAAGCCACTGCCACACGTCTGACCCTCTCCACCCCATAGTGAGCGGCTGCTTTTCCCTAAGCCAAGAGCCTCTTGCGGTCCCTTCTTACTCACACACAAAATGTACCCAGTATTTTAGGTAGTGCCATATTTTACAATTTGTAAAACAAGCACGAGCAAAATGAAGACACTGGCTCATATTCCTGCAGCCTGGAGGCCGGGTGCTCAGGGCTGACATGTCCACCCCAGTGCACCCACTCTGCTTTTTAACTGGGCAGACTGGTAAGCAGACTGGTGGGATCTGTGCCCAGAAATGGGACTGGGAGGGCCCACTTCAGGGTTCTCCTCTCCCCTCTAAGGCTGAAGAAGGGTCCTTCCCCTCCCCAAGACTTGGTGTCCTTTCCCTCCACTCCTTCCTGCACCTGCTGCTGCTGCTGCTGCTAATCTTCAGGGCACTGCTGCTGCCTTTAGTCGCTGAGGAAAAATAAAGACACATGCTGCGCCC + IK9KKIFIHKDIJKKIKHFKKJJGKKKHKKKIKKKGKGJKJ;KKKKKKICKJKCKKGKJKKH?KEJKFKKKJKKIKKDKDJKJKKJIKKIKJKKK,KKJJIJKIKKKKGKIKJKKJKKKKKIKKKHKKFGHEKJ;KHHHDIKKKKJKJJKIBIKKDKKKKKKKKHKCKKIFKJFJKJKKKJJKKIKJ:KGIKKKKGKKJ9JJKJJKFKKKKKJKJJKKJIKKKKKKGKKJKIHDKKI4JJKIKFKJJDKKKKKKKKKKGIIKIHKAKKIKKIKKKKKFKIJKFKJJJKKKHKKKI'KEK>KI>HHAAKKIFKAKJJKGCKJKIKKKIKKKKK@KGKKKKHHKKKK?KJ=FJKKKHKKJKJKIKJ=KDKJKDJKIJKKJ:K@EHHHEJIIKJKJ6JF?HKI@IEIEIIEKKIKGKKKKK;JKJFKKKJKKGKKKGK;JKKJJKKKIKKKKKKKKFKFKKKJKKKJK8CKKKKJKKJKHGKKBKKJKKJHHIKIKKK:KKKKIKKKKKHKIKKJ)KKE'JK=JIICKKKJDKKHK@KFKGKCKK:KK?KKKKKA-HKKKIKKKKKKKJHKK;KK4KKKIKJBJGKIKKKJKKKJKKKKKKGKKKKKKKKKBKIKKIKKJKCKKKKKKJJKKK8KKKKKKKKKKKKKKKJKHKKIKKKKKKGIIIKKKKKKKEKJKEKKKKFCJI3KKHJG?JEGFKKKKKKIKK@KJKIJJKKIDKKKKKKKGKKJKKKKKJKK7KKKKKFKKFKKKKJKKKKHKCKIJKHKKKKJKKKJKHJKKKKKKK:KK=KKJKDK6KKKJKKKHJAKKKJ6JKEKKDKKKKKKHKKGKK1KKKK;KKKKKIK?KKKK@KKKKKKKKJKKIKIKJHEKKKC>KKJEKKJJEKKEKKKKJKJKKHKKKKGIKKJHKHK5KKKKKFKGJEKIKKJJKKJKKIJAKEKKIJKJJKKKKKKIJH=JIFKKCGCHKKFEBIJHKGHKHKKKJKFKJIKKKGKJKFKKKKKJKKJKKHJKJJK9KJKCKKKGKKKKKKK@KKKJK4KKKKKKKKJKKKKEKKKKJKDKKGKJIKKKJKKKKKDECHKKKKKKKKKKKKKKKKKKKJ4KKKKKKKKKKJIKKKGKK7IKJCKKHFJECDI9IJIEJE?AGECJGKJKKKKKIKHK>BJJAKHHJGKJIKJK)KKKKKCKJHI8KGKJKKKE?JJKKGKKKKFKKKKKKK4KKGDKKKKJKK8KKKKKIGIJKKDKK?KKKJKKGKKHKKIKJKKKJKHKKKEKKKKKKKKKGKKHIA>KKKIKKKKKKKKKK>KCKKKKKJKFKKKKHKKGKKKHKKBKKKKKIKKKGKKJKHKJK@JIDKKKJJKDKJKKCKKKEKHKHKJJJI=JCKGKJKIKIKJK>KKKJ?KKGKKJJKKBKJKGKIKEKKKKKKJKJKDKKKKKKKKKKKKKJK;KKKKIKKKKIGKKKKKKKJIF?KKKKKDKJKKHFIJKIK;KKIKKKKK>KKKKHKKKKJKKKK.JKKKKKKKKIKKIKKJJJK4KKKKHKHKHKKKHIJKKKKB>K=JKKKJKDKKKKKIKKKKJIHKKKKKKKKFKKJIKIKKI9KKEKKKKKKKKCKKFKKGIKKIK/KKHHKKKKJKKJKKKKKKJKKKKKIK'JJI=4DKKKKIJJHKCKJKKGKGKKKKKJHKAEI;KJKJKIJ$HKKGKKJKKGIKJKKIIKEHHKFJGK5KIICKKKKKKKKJKHHKJKIKKKKKJKKKEKKK@KKKKKCKKKKHKKGEKKKKKK>KD @rCer/898/1748_55_CCS GGAAGCGAAACTGGTTTGCCCTGTGGCTGGACGGGACCCTGGGATACTACCAACGATGAGACAGCTCAGGACGAGGAGGACCGTGTGCTCATCCACTTCAAGTGTCCGTGACATAAAGATCGGCCAAGAGTGCCATGATGTGCAGCCCCACGAGGCCGGAAGCCGAAGATGGCCTGCTAACTGTGAACCTACGGGAAGGCGGCCGCCTGCACCTCTGTGCGGAGACCAGGATTGTGCACCTAGCATGGAAGACAGCGCTGCTGGAGGCAAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCAGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCCTCTGGCCATGGGGCATGCTTGCGGGAGCCGCCACTGGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCCTGCTGGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTTCTTCCTCCTGGACCCCGCTCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTTCCCCCCACTCCCTACCCTCACTCCCCACATGGGAAGAAAGCTGTCATCCCAGGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCCAGACACCCCCAAATCTGTTATAGGCATTTATGGATACATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGGCTTCGAGTTCCGTAGACACGACATGAATCGGGCTCTCTGCTCTCTCGTCAGGGAGCTGGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGGCAGAGAGCAAGGCAGGTAGGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGGAATTAAATGGGAGTTCATCTGGCCTGGGGTGGAGGCCAGGATCAGACCATGGTGGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGGAGATGTGAACGTTCCCTGGAGGGAAGTTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATACGTCCATACCCAAAACACCCCTGCCCACAACCAGCTTCCTGGCTGGTACCATGATAATATTGAGCTGAACCTTGGGCCCCTCGTTGGGGAACAGGTGAGTTCTATTTGAGACTTCTAGCCCCAGAAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCCTTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACCTTTACACCAGCCCAGGAAGCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCCTTTTTGGTCCCCTTCCAGTCTCTTCCCCCTTTCTATCCCAATCACCAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTTGG + *%%%$&$$(#&&)%(($%()%''()&#'($&$))&%(((''&&&&%$%&%##""%%&##$$$('&()'(%'%$('%('%$$%&'%('('(&')'%&&#$(%"$#%&$%'$%%"#')&(&%'%"('($&('$(&'&%%$%&&$$$#))($%"'$&#'#&%""%&(((#%(()()((&$())&())'(#(&*--+('('-)#&'&&('#+**$)),,&+(**-)*%)+*)*#+#!$''##'&(&//,/1-2--,-/+110,/)0+-+2/10.,1/1+//+,,,(+,.+'(&.(,0+(.)+)',1,.+.*-&*/-+(*)1/,0,+//2022,2)+-,-.**,*-,10.(*$&$+*2)10)/+',,0--.**,.,,,(,),*1--)))%(-''#(%.,0%&&*1.,1)&*/00,&&+-).1.01.0.,0,,.*%++-+.0-.2'-+..//+%('*$#,0.*(-(.(//.(-/+-,,//-4,0+0-,/0.0'1-12661(-4.'12),,223*505434502522-20,0/5,36../,,*0,/10/64/.//0-+*-103+/2/0.)+-)+)%,5//-40+'+/0412-/+-,02./,($&**2,/-'%///41,*45413)/0'-(02.0305432(.1-/23406/52(-3-50.0*1./%.0200(23046.+*+((.)*'(0,,.-+/.+21/+,(&&0+*((-*+)+),0-+00,,).,)00(-)20+*/13/0140514642/0(./+00424/)1(-)03.*++)'/13,46-501/0102,12/6315150),.3321-3.)03654255'-0/-54620/6556345134154/654050+452/50/-26(0333*56101433-14.*,21*/64366443*44-1212-*14*%1564525101443)23/,-&,3./*/**$1*36,55305+51,)316.45,252/1/+.433+-+0,,$5333-55663634221125/*,4,5013-4664-.2-.)-.($()+1451)4553246-12)2*/324-63(3,/.1,445466/243'/313440532&653/00%153551656552124,-65305/-36+20405215334,63.021*603645.006/411-)-++./--,114466044*433*41203..(542513452130161-./3402514355/-3./32136321465,5236000'12.232-1.636,21663225.*%314416346,0/5.521$)3-.164/%2+4*00)*1*/0--,*$)0/'00.,++24-0,41.0-3/45424.34-53/+0231)/3141)31445+033605604.2054550044520.044063*0.(.-+2633233(3646*54665111532131044-,/.5443/401.0'/12266562.14.24611$/5405064)005)40(2522510+656514/(&30200&/'0$(466-02-33.22$.4+23,5/*+-0-(.4250/0)/3'/.(-2+/-/556*1233&5-0450',,,-/240/4/11546,25-//+-0.*311./2/3().*14101./3*43.430103416/&2/-,/1300545504*455,155321453662141//)..3134-4-,0/00421/(&,,00)6-+40*343/'.,640- @rCer/902/25_2589_CCS ATGGGAGCCAATTCGTCGGCTCGTGGCGGGCGTGGTGGTTCTTGCCCGCAGTCCGCTGTCCGTCCTTCACTCTGACTCTCCTACCCCGGCTTGTCTCTGCAGAGGTCACGGGAGGCGGGGCCCCGCACACGTCCCCAGTGGCAGCGGGAGCGGCAGCTGCGGTTCGCTGAGCCCCCGAGCCCCCAAGGGCTAGAGGAGCGCTCGGCGGACCAAAGAAAGCCCGCGAGCGCTGCGCGCCCACCAATAGGTGCGGGGCTCGGAGCCGCGCAGCCTGCGCCGTCCTCCTCCGCCCCGCCCGCCGCCGCCGCCGCCGCCTCCCCTCCTCCTGCTCCTGCCTCGGCTCCTCCGCCGCGCGTCTCGCACTCCGAGAGCCGCATCGGCAGCGGCGCGTCCTGCCTGCGGAGAGCCAGGCCGGAGAAGCCGAGCGGCGCAGAGGACGCCAGGGCGCGCGCAGCAGCACCCACCCTCCGGACGCGGCAGCTGCTGACCCGCCATCGCCATGGCCCGCGGGAAGCCAAGGAGGAGGGCAGTTGGAAGAAATTCATCTGGAACTCAGAGAAGAAGGAGTTTTTGGGCAGGACCGGTGGCAGTTGGTTTAAGATCCTTCTATTCTACGTAATATTTTATGGCTGCCTGGCTGGCATCTTCATCGGAACCATCCAAGTGATGCTGCTCACCATCAGTGAACTTAAGCCCACATATCAGGACCGAGTGGCCCCACCAGGATTAACACAGATTCTCAGATCCAGAAGACTGAAATTTCTTTTCGTCCTAATGATCCCAAGAGCTATGAGGCATACGTGCTGAACATAGTTAGGTTCCTGGAAAAGTACAAAGATTCAGCCCAGAGGGATGACATGATTTTTGAAGACTGTGGTGACGTGCCTAGTGAGCCCAAAGAACGAGGAGAATTTAATCATGAACAAGGAGAGCGAAAGGTCTGCAGATTCAAGCTTGAGTGGCTGGGAAATTGCTCTGGATTAAATGACGAAACTTATGGCTACAAAGAGGGCAAACCATGCATTATTATAAAGCTCAACCGAGTTCTAGGCTTCAAACCTAAGCCTCCCAAGAATGAGTCCTTGGAGACTTACCCAGGAATGAAGTATAACGCAAATGTCCTTCCTGTTCAGTGCACTGGCAAGAGAGATGAAGATAAAGAAAAAATTGGAAATGTGGAATATTTTGGACTGGCAACAGCCCGGTTTTCCTCTGCAGTATTATCCCTACTATGGCAAACTCCTGCAGCCCAAATACCTGCAGCCCCTGCTGGCCGTACAGTTTCACCAATCTTACCATGGACACTGAAATTCGCATAGAGTGTAAGGCGTACGGTGAGAACATTGGGTACAGTGAGAAAGACCGTTTTCAGGACGTTTTGATGTAAAAATTGAAGTAAGAGCTGATCACAAGCACAAATCTTTCCCACTAGCATTTAATAAGTTAAAAAAAGATACAAAAACAAAAACCTACTAGTCTTGAACAAACTGTCATACGTATGGGACCTACACTTAATCTATATGCTTTACACTAGCTTTCTGCATTTAATAGGTTAGAATGTAAATTAAGTGTAGCAATAGCAACAAAATATTTATTCTACTGTAAATGACAAAAGAAAAAGAAAAATTGAGCCTTGGGACGTGCCCATTTTTACTGTAAATTATGATTCCATAACTGACTTGTAGTAAGCAGTGTTTCTGGCCCCTAAGTATTGCTGCCTTGTGTATTTATTTAGTGTACAGTATACAGTGCATACTCTGGTCATTTTTCAAGCCATGTTTTATCGTATCTGTTTTCTACTTTATGTGAGCAAGGTTTGCTGTCCAAGGTGTAAATATTCAACGGGAATAAAACTGGCATGGTACTTTTTTCTTTTTTTTTCTTTTGTTTTTTTTTTTTTTTTTTTGGCTCTTTCAAAGATAATGGCCCATCAATGAGCATTTTTAACATACTCCATAGTCTTTTCCTGTGGTGTTAGGTCTTTATTATTTTTTTTTTCCTGTGGCTGGGTGGGGGGTTGTCATGGGGGAACTGCCCTTTAAATTTAAGTGACACTACAGAAAAACACAAAAAGGTGATGGGTTGTGTTGTGCTTGTATTGAATGCTGTCTTGACATCTCTTCCTCGTCTCCAGTATGTTCTAAAGCTGTGTCTGAGATCTGGATCTGCCCATCACTTTGGCTAGTGACAGGGCTAATTAATTTGCTTATACATTTTCTTTTACTTTCTTTTTTTCCTTTCTGGAGGCATCACATGCTGGTGCTGTGTCTTTATGAATGTTTTAACCATTTTCATGGTGGAAGAATTTTATATTTATGCAGTTGTACAATTTTATTTTTTCTGCAAGAAAAAGTGTAATGTATGAAATAAACCAAAGTCACTTGTTTGAAAATAAATCTTTATTTTGAACTTTATAAAAAAGCAATGCAGTACCCCATAGACTGGTGTTAATGTTGTCTACAGTGCAAAATCCATGTTCTAACATATGTAATAATTGCCAGGAGTACAGTGCTCTTGTTGATCTTGTATTCAGTCAGGTTAAAACAATGGACAATAAAAGAATG + 34&40,3+446/6245.,312244)14(54254+443656416+)-/1.45..401#032253-54642414042//.,)303&20304422665.2316454.1.-65(...)2('315*3/655666415/643/45165661(44/*3//5.65153&/&2156552-#-.1141.(135506*500*23204.+15422560560/4(32&-655/361410//(..5.14,&/3415,'-5/3125-6650352225+25666662655044662$2/)40/*4&0301*644/65(44064*55550/4/'203/1225665/0+1.41401+655462065'4556456526435251540/45+556514/6664536665314314*4564(253141415606160326132445656626544+556656556520/1545.+./1%,%/-*$.%'16+523%-/5.).3-13442&.//*.4145)25556'4.2)+65)330214131&2/(4510//4+5465+51)/05145%246-225664263565353#4455$*.-5*3.35/40/3515.436065.1/.4)3)5550&5(0/42356-5/66552+*4/11465666432066462+1-$,-556641616/12403420*/415540-,021015061220633563/2/0.02,20/-2*4%432311.+0-,4422462+.44%24022)24526653326*451060%441/44265-25532'1,+21/3335650)322455021*2.-6400/.)42/310,34*,(1255.04,23410653616//.%$.2164144342+26665*-2-....04546552-*.25/5564%2,-26215543*02415163244+-*156/,5'2..*.65,05165/243656366231.'33-15*21/356,44450426565536.520/424.5551640-5-/45262232620+2/*45+424(13/444/446660-416/1535610)55166256/1304)(1,#1),53/10)+-/).+5-4455/,23+10246041304.-()$4025/56143144603/2355110650*.*23*3.3,11104&313400//-06555.1.65661/+-605./,262+4-1($0-+0'$+.0.%0)5454645)14,213-,,50355/2152-./036541443/1.,66,662356660,0.56415.4*31-40%.12%13425315-/-44163426566465%2./6-2,++.1-10/+,-+&(*(/-/+*-(-,01/*-$*(-*-0111..,)100-.0(1.,*.&-.1+$*,+-/11)'00.,.1--/(%&.),+(,011,1,.11/-(&*,)/..2.20011-,(/(',)11121/2'-,++/,/0-0-)011/%#+-/*(0+.,.+.(+,+(%.&%++*''(*''+-),,*#')+)+(()(&)(12.*,//,011*-,*,%$+0./'-./*-0-,.1,0.-/-1.0'//)+*&/1+)$0-)/-/-11201-101(&0++$%++1012-110.01+.2&+,/*/11-.02221.2202-1/,*+.,0022.1(10%..-'0-.-,+1//'-,/.+))-...1,.-01/01.+1)*,,**'01.,.+%.,.0&./200102101,/*110(0-20/..,$1/)#&))*+.)/000,+$..-#(--)$.11-./21-.&+0./+&01.21-/)000/,./*011,1)111.*10,22.-,1111,/2.0+22/,11.0,/2+/+%..02.0*2.12/$/,*,,&)/00-,1111'001'&$(.00+$./10/000.--*/*$---,.*+**++,-*)((+%&111,1,--.2110-0/,/%/,--0&*/101*/)1001,21.&,11+-/--+(./22.,1/./*1-,),/(&#(,22-+1)%/1100-/+/,/(,-&+(#%''*$*,00//2*/1++&.--,+.*)-+..'0,*1.(--%(&*00.1,--,//+2/0./-.+1+1-.0.110',..2/,/,.0/01,0,)...'-21',.'-+(/+,,+1.1-11%0.11))$%...0.$(+00/++2./110)0/01..101/*-*01-/%.-/1-0/+0,'.+*,,*/-,+),--.020212,220%%-,.,10)1110'/1-)/$-.0'111111,./2211*11+00-./0.+1/1,-./1.$$*&,0*1+&)..2-0&,-('002-',-*001-1*+0*1%+.(..)00/)'101.1.,.1,/.004-331,$-+141'.3,.50)32201-55155/)0/0,42/*66564.450/5453023635666-.560/*3.++1154/4456354(553-*.0+1*560243+6441,25/2/11/+.3#205/31004,431051'3//224420.24+-61,)/022)40-6565*4.0502//5.115145,43554250/3/3/,/15466144-/,32120650433-.-'-&03.+32 @rCer/903/28_1701_CCS ACAGTACCTCAGTTTTCTGTCCACAGCTGCAGTCGCTCTGTCCCTGGTGCTTCACTGTGGCAGCCAGGGACAAGCTTCTGAAAGCAGTGTGATACCCAAGTCATAGGTGCTTCTCGTGTGTGAACAGGTGTTATTCTGCAGATCTGCTATGTGTTTTCCTGTTGACTCTTTAAGAGTCCCTGCATGTAAATCTCGAAGCTGAGCCTGGCTCCTGGAGGCCAGACTGACATTACAGTGCAGGAGTTTGCAAGTGTGTCCAGCATGCACGGACTGTGCAGAACTTGGCTCGGTCACTTTGGGTGGAAAAATAAAGTTCATTTTGAAGTATCTTGAGGGTTGGGTCAATTGAGACATTTCTAGCATTACTTAATGACTTGCATTGTGGTTTTTCTGCAAGCAACTTTAATGACTTTTTTTATACCACATGGTCTCCCAGTTCTAGGTGAATGCAACATGATGATGGTGATGATGACGATGAGTTTAATCATTGTTCCATTTATTGCCTTTAGGCTGAGGGAAAGGGAAGATTTTTTTTTCTCTCCCATTTTCCCCCGTTCTGTCTTTCTTTTGGTGGCTTACACCACACTTAATGACGCTATGACTAATTCTGCTCCCAAGCCCTTGTATCTTGGGCTTCGTTTTAGGCTCACGTGTCAGATCTGCATGCATTGCTTGCATTTTTCTGGTATCTGAATGTTGGTTCCTTGTTCCAGGAATTCAACATTAATTTCCAAAAGTATCATGGACTTGTGACAACACAAGACATAAATCTATGTATAAAATTTATCGGCCTTTCTCATTTACCTGCTCTAGTATTATTGTATTGTGTGTGCGTGCGTGTGTGATGTCAGGCTGCCACGTAAAACTTCAGAGAAAAATCTTAAAAGCAGACCATCCTTTTTTGCATGCTCTATTCTAAGTAGAATGTTCAATGTAACTGACTAAAATTGCATGTTAAAGATATTTAGGTTTTTTTGTTTTCTTTATTTTTATTGTTTTCAGTTTCCTGTATATTTGCTTACTGTGCCGTTTTAGTGGTTTTAGGATAAAAATGCACTGGTGAAGCAAATGTAGTGCCAACAGAAGGTGATTTTCCAGTTGTAAATGTCATGCAGCATTTGAAGGGACTGTGTTTTCTTTAAAAAAATCACAGTTACTTCTAAATCAGATTTCGTTTCTTTTATCGTTTTATGTGCCAAACCACGAAGTGCATTGGGCTTGAATCTCTGAACACTGTAGACCCATTAGAAGACTGTTCCGATTGTCACAAATTGTAGTGCCTGAAAACACTCTTAAGCTGATTGTCTTAAAAAAATGAAAGTTCTCCAAAGACAAAACAGGAACAATTATTATAACAAATAATTATGGTTGAAATGTCTGTGGTTCCTTGGAAATGCTGCGCTCTTTGTGTTTTCCATCATTAGTGCAGTTGGAATGAATGTGTACAGGTCAGAGGTCTTCGTGTTCACATTTTAAAATTAGTAAATGACCTCATCTTTCAAGCTTGAATTCATTTTTAATTTTAATTTTATTTTATACAATGTGTAGACAGTTCCCTGTTCTCTGCATTTAGAAGTATACACAATATAAATCTGTTAATTCTGTAAGTAATTTTTATAATTATGATGTAACTCTATCTTATCCTTAAAACATTTAAAATAAACCCTTTATGT + <=HDCDEHGIGG/JJGIBH>GGIFDHIG0EE?DHFF8@7GICIIFCJEFI6IECBCDF&CCAA:E??IFDB7GB?-AA;CBJJ;>+6==FBAAE=GJDJ?EEFCCGIHBF.FADAC6<96C'8EEC8FF>+;H9HGA9HA=CGF?GFBD::;;+DGI=JHF7GG8EEIB7IJHB/EHAJH;BHGC6EC0?B>.BA9DE>GDJE:E?3DDEJAHFH:EEDIF7K?DBKKID.F9>JEJE+CGIGJ4IGHD1IIHKKKFKKK9KKKIEKKJJHEHKGE(KK@K6KKGK7KDKKDEKKK:KKJKIJKJKKKK?K;JHKIIFKKKK*FFK,H+KKKKJGKKEKKJ3KK4KKIKJJKI&IKGH>@H4-J84I@GE@A:GIKHJIJ4KJCKGKJBKK;K6KJ,KKKGKK>KEKKB$KKKKK=JK:KJ+JK:KJI#KKKKKKKJCKBA0GDJ;KKK0KKKKJFKJGKKG(KKE.KKKGKJ8KKIKKKH6KHKKKJKKKKJJKKKFJHIKKKJK>KHIKKB*KGCKI8KKKKHKKII?K-JGG8KJK1KKKI>KCJKKG5A8BKHKGH>IKKKK$K9H.J:GDFI@K?KIDKIHK'KKKHIK;8'KKKKCKKKKKKKKKJKEI7KKHJJGDJJ@KIKDGKIK=KKIK:KKKCKJC=KK;7KKKJKKAJIJJKIJIKKKFKFKKKKEKKJ@KKK?AKC+KKJKKKJIIKJKKKKKJKKIAKKKKKIKAKKJKCKKKGKKKKHJIIKKKJKKIK:KBKKJKCKKJKGKKKKFK,KKK2KKDKJKKHIKJKJKIKKHAIJ)KKKJKKKEKKJIIKFKJKKFHKJKDKK3KJHKKKJKKI=KKK:KKKJIEKKEKKK/FGKJ*IKAKJK5KKKKKKKI)KKI=KKK@K+ED0;H=IKKJG4KHKH=K:KI2@:A4@@'DC=;DEKFG;I;KFEJKJFCI?9@0J?J?H=J>I@FEJJGKFKJA;=/ED;:C0EJJCJ@EJE.CF;JKKF>:K9K+H-D:K5AKKFFAJHKIKIKKJKKKKKJKKKGK&KKKIHGKK-KKKJFJK0KKJKKJJJJ @rCer/905/1882_67_CCS ATGGGGTCTCCGAGAGGGAGACCGGCGGGCCATGGCAAGCTCCAGGCTTTGGTTTTCGCTGCTGCTGGCGGCAGCGTTCGCAGGACGGGCGACCGCCCTCTGGCCCTGGCCTCAGAACATCCAAACCTCCGACCAGCGCTACGTCCTTTATCCGAACAACTTTCAATTCCAGTACGATATCAGCTCCGCCGCGCAGCCTGGCTGCTCAGTCCTCGACGAGGCCTTCCAGCGCTATCGTGACCTGCTTTTCGGTTCCGGGTCTTGGCCCCGTCCTTACCGCACAGGAAAACGGCATACACCTGAGAAGAATGTGTTGGTTGTCTCTGTAGTCACACCTGGATGTAACCAGCTTCCTACTTTGGAGTCGGTAGAGAATTATACCCTGACCATAAATGATGACCAGTGTTTACTCCTCTCTGAGACTGTCTGGGGAGCTCTCCGAGGTCTGGAGACTTTTAGCCAGCTTGTTTGGAAATCTGCTGAGGGCACATTCTTTATCAACAAGACTGAGATCGAGGACTTTCCCCGCTTTCCTCACCGGGGCTTGCTGTTGGATACATCTCGCCATTACCTACCACTCTCTAGCATCCTGGACACACTGGATGTCATGGCGTACAATAAATTGAACGTGTTCCACTGGCATCTGGTAGATGATCCTTCCTTCCCATATGAGAGCTTCACTTTTCCAGAGCTCATGAGAAAGGGGTCCTACAACCCTGTCACCCACATTTACACAGCACAGGATGTGAAGGAGGTCATTGAATACGCACGGCTCCGGGGTATCCGTGTGCTTGCAGAGTTTGACACTCCTGGCCACACTTTGTCTTGGGGACCAGGTATCCCTGGATTACTGACTCCTTGCTACTCTGGGTCTGAGCCCTCTGGCACCTTTGGACCAGTGAATCCCAGTCTCAACAATACCTATGAGTTCATGAGCACATTCTTCTTGGAGATCAGCTCTGTCTTCCCAGATTTTTATCTTCATCTTGGAGGAGATGAGGTTGATTTCACCTGCTGGAAGTCCAACCCAGATATCCAAGACTTTATGAGGAAGAAAGGCTTCGGTGAGGACTTCAAGCAGTTGGAGTCCTTCTACATCCAGACGCTGCTGGACATCGTCTCTTCTTATGGCAAGGGCTATGTGGTGTGGCAGGAGGTGTTTGATAATAAAGTAAAGATTCGACCAGACACAATCATACAGGTGTGGCGAGAAGAGATTCCAGTGAACTATATGAAGGAGCTGGAACTGGTCACCAAGGCCGGCTTCCGGGCCCTTCTCTCCGCCCCCTGGTACCTGAACCGTATATCCTACGGCCCTGACTGGAAGGATTTCTACATAGTGGAACCCCTGGCATTTGAAGGTACCCCTGAGCAGAAGGCTCTCGTGATTGGTGGAGAGGCTTGTATGTGGGGAGAATATGTGGACAACACAAACCTGGTCCCCAGGCTCTGGCCCAGAGCAGGGGCTGTTGCCGAAAGGCTGTGGAGCAACAAGTTGACATCTGACCTGACATTTGCCTATGAACGTTTGTCACACTTCCGCTGTGAGTTGCTGAGGCGAGGTGTCCAGGCCCAACCCCTCCATGTAGGCTACTGTGAGCAGGAGTTTGAACAGACCTGAGCCCCAGGCACCGCGGAGGGTGCTGGCTGTAGGAGAATGGTAGTGGAGCCAGGCTTCCACTGCATCCCGGCCGGGGGACGGAGCCCCTTGCCTGCGTGCCCCTGTGCTTGGAGAGAAAGGGGCTGGTGCTGGCGCTCACATCCAATAAAGAGTAATGTGGCATTTTTCTATAATAAACATGGATTACCTGTGTT + IDKII?I:GCDADEHKG'@>ABFIG=EBBCJJF>3FB1@C2JIHD:AI4@5FH>EHKF>FJJHBGIHHKHHKFGDKDJG?IGCIKKIJKGJCH?JIIBBFE@BFFFDGCAFEG?FHJHHHKIIJCHD9EH8FHIEF@EABKJCKGCJI@IHJE/=IF:JGJ:=88&EGGKHBGDBGEBCGFIII?;J6>6GH?IHFIIGH9FGE=FDDHKDGIJIBH:FDCHGDEBE<:GAJ=2HCHJH:HA>:B@A8?3ED8AB@BFJCD@EC<<>AC?GKHDHDJJ;<;K0GKJCDE3FJH;D9CB6FKCHFHHDFF@?JHKCEGEKIFHDBDIEIC@CJJJF>IFJF;HKCBH8IGI?JG=BFEA7DI@FIJFIFAGHII?GIGJIHHDAA?=EFDIKJI@<@B@HGHHJ?HIJBG:ACI?D9HB=FIHDG;>=IIK@DG@;KEHG+D@;CGIIDE>JABH=GKJHKCJ;;HHHGKKGHFA8EDHKAIK@BD1GABFB-G1AGIIJJHJGF=<;C@F);IGJC>EJ8EIKHECGKIGIGKCH:KIJJHE@J4C9KHKKDKJKHKK5BJAKCAFJIKIJKK@F*IKKKIKIKKKJJ>KG@HBDKJKEGJIJKBGJKJJKBJ;KHKKKK?KKJKKKKIKBJ=KKK?FKJKJKKAJKAKH>?KJKJKKJIKIEKJJJJJHIJJJJJHAJBD<>DFEA8GD:IJJFKKKKKIIIECBEJHGKHKC=JHFAGH7GJGG=EEGDCKCH@>G9G?HKH8BHDEC6C==EBD>GH6HJCJIFI=0?>:8:AH@DBFG:HGHAIF=7=DKHI=FH>7<=,=FICEBIHDI@JGGF83HC@D>@KIKAEICAC.AFI5BGFDHIIC9@HKDABHEIAK;JKGJGIGFIFCD/GGJIHIEB@JJFJKKEJIFADF=?7IH?C9@>;C4ABE;A=B/@BD67@HE@AB@7IEHIGFGG4F=D?A8IFD@EB @rCer/906/2231_60_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCATAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCGGTGCCGCTAAAGCCGGGGCTCTAGGCAAGCTGGCTGTGACTTACAGACTCACGCACGGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTTG + F@A=:+41;E7BBE7EBCDC>=CE@@FE?9B-:E@=E8A>748D<@D?C<>C>=BD9DE>8?@<9B7FEB@A:968@7BB>A>C>@GDDAG9CABCCF;AEBB>E7DAEAB>AC=85+$8CA?@5??>DBEB>F=C==FDF>@BE9BC?D@AC6=EE6ED6>3?=?:7@E6-*.$""$"#"!!"+&<=%0/%)$%"$&'##'@<%1($$4$/%)&!$#&,-@$"*>$',(#$&'".+==1CB94?9AF@CABBCA>=@EF;BCDBE/:DD@>C8C@AFCCG@GFDF?@BEGD5BEFF.9A9<>9B83EAFCD@AGDB>?FAEA::9418E?DC;6=?7>BD?9A4BC@G=EC=CE83;?66.=CFDCCC@B=>7<3?*9<-BG@F@=7;7+?;@9@<4@?>->A@?=A?;BA/A84:;CC/<@=C;:;8:=8<438/;1+A4=7@6137=9;698;99<;;<9;==*==8864&+74?;1+:3:>2;69:3;8.>>;;<=5>58=97674=;*;-77<1;8+?=<9&6:?55;=<<05<99:4:/780<6:9=>58<93:9970/59&/?71/7.=?;5,;<:367=1;4;;9)<4=<49=352:<26<<+=77;/:656&6>5:90:570;69+<:;>24<.;;?=8:;4-3===:4:;>;::02:9==?;68;1.780808/9=;;5=6>2<69542$145<:61)=9:&<>;;<;::65??7<5?8;=>;<;/=;>=0<:<:>:7=<98<<-9:78;>;;;0';;*23/9>=3:31$-=?98289#7;;;359.)857739<:;;<5<>89897+>9;<>072929477>=;7?59;>;8.>;;><486;9738,9601/763*2<,79;<::?<8<<>?99<76=:5=09<78;797.6442:8666;9<=#===:>1;.<;187=?9:;2866*::9:7;<6;66:8:)<9;?;<7=7:=7=78>;84<;1?9.:86(7516:244;4/58:/8998:;/::<=86887>99=;9=43855;4>6;7<:22%9/2>799<38849:;<+:77>837=+<;>;9:4:4<;>;6(35797:35*83==;73=7<5:3.8221=>:7>;>==93<>6<6=69676-8<:58:=?=7:86716846=340:72:4<;;1:9/<47>5;66-;3<:38=:;=5958>::;::4*1477:6895:3<96:5686:97<88.6;::;-8<)*34479C?:=:18:@><<=:A:@;>>;/A5B>-?915<;BB<=?=@A9=8?::;=C?=@0=<;1:A<2;7@C?ACC>C?>@8=@?A68??=?>@A>;=;95>8?B7?=>@:>>=?97.5;<76A98;>>>AC>BA4>>8998:0>B>?A=>>5?8;>A>8495=637<>??:-74761;4<@9?@>A;BCCCBB3:56A9@>/B=?:@?><@*'.8>+;=3?9>;8@A=:A<86BBABA;6)8.<>4@?2'%:9C@C2@C>>ACA8BCCB@8;=>@5AA4<;B?@<<>A:C?A7:0;B38:9,9<-6;<0AB@C@<;A@;@<994::;+5>?5@=>8/9;>=5A?6@<,>*<)<6@C9A@BC@=4;7;;;@>?=;<8-;7>@@7>B@4;:A0>C>?8?=AC>B?BB6;B@A?>B?C9<@>A8)>-=B;:3+=:@-?27;A>=@>7=9?*A@???AA.A;8?A7?>CAAB=BA>@7B?BA9:)>BA7?BB;@@59BA?A@B8A?@-A>7=;?A7=@.B>==3?8:A:==4:B>:4?B8B@BA<@@BC@/<19:<9>@C>>>=7<>AC>A@AA=6;AB9<;@9<7C9ABB2$/' @rCer/907/25_2178_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAATAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + 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@rCer/910/23_2099_CCS AGCTGTAGACATACACTCGGCGCCCCTGCGTCCTAGGGAGAGAAGGTTCGCCCTCCCAAGGAGGAAGGCTTCCGGTCAGGGCCCCCACCCCAAGGCTGGGGACTCCAGGCCCCTGCTTACTGTAGCTCTTTCTTCCTGCACCCTTGATCTTTGGGCTTCCGTGATGTCCTCAGGTCCCCCACTTCCTCCCCGTTGCTATTTCTAACCTCTGGTCCCAGTGCCTGGCAGCTCTTTGGAGCTGGCTCACATTTCCCAAAAAAGTTGATCCCTCCAGTGGGCTGTAGGCAGGACCTCCGTGGTTTCCAGTCCCCATTACTGGCACCGGTCTCCCACAGGGGCTGGTGGTGTCATCACCTGCTGGCCCAACTACAGCCTGAGCGGGCCTGAGTGGCCCTGGCCAGGCTGAGACCTGTCGGGCCATACTGACAAGCAGAGGTCAGAGACAGTTGTGGGGATGAAACCCTATCCCGGGACATGGGTTTCCTGTTCTTGTACACTTCCCTCTGGGATCAGGTGAGGGTCCAGACAGCTGGCCAGGGACTGGTCAAGACAGTCACGGGAGCTCTAGGTGGCACAACCAACCCCTCTCCTGGGAGGTCCCTGACCCACTGGGGATAGGAGCCTGTGTCCCTGGTGCTAAACACTCTTCACCTGGCCGTTGTTGGTGGGGGCTCCTTTCCTGCCAGACCACAAGGCCAGAAGCAATAATGGCACCTCAGCAGTTCCAGTATGGATAGGGGTTCCTGTTTTACTAGCTTTTACATCTCCTTTTATTTAAAAAATATATATGCCCCAGATGTCAGAATGAGGGGACTGGGGCACCATCCTCACTTCCCAGGGCTGGGGGAAGGGGCAGGATCATCCCCTCCCAAGGAGATCTGTGGGGGACCCACTGTCCAGCTGGACTTCTCAGCCTGAGTTCTTCTCAGTTTGACTAGAACTCAGGCCTGGAGCCTGGTCTACCAGGCTCCTTGGGGCTCTCTTGTCTCAGGCCAGCTGGGGATGGGTGGCTAGAGTGAGAACTCAAGCCCTGTGGCCACAGTTCTGGGAGCCTCACCCGGCTCATGCTGCTGTAGTCTCCACGGTGCCCTTCACGAGGCTTGGTGGTGGCAGAATGGCCATGCCCAGGCGTGTGCTGAGACCACTGACAACTGCTCGTGTATAGGCACCCCACAGCCCCAGAGTGTGGGGCACAGCAGGCATGCGAGTGAGAAGAGTGAAGGGAATAAAGTCAGTACAACTCGGTCCCTTGGCCCAGCCTCTTCTTTGCACTTGGCCTGCCTTGACTCTTGGACCAGAGCAAGGGGCTGGGCTTTGGGGACTACCCAGAGTCAGGAGCTGAGGCAAGGGCAGCAGTGGGGATGGGGGATGGGCAAATAGGTGGGTCTTAGGTCAGATGCAGAGGGGCATGAAAGAGGAGAGGTCCTGAAGGTAATGGCTACAAGAGCAGGGCCTGTGTAGGTGTGGTTCCTGTGAGCACCAAGGCATGGAGCCACAGGAGCTCCGGGACAGCGGGACCAGTGCTCCCACTTATGTGCTGAGCCCTGGGGATGCTGTGATGAGCAGTATGGACTCATCCCTCCCTCGGCGGGCAGGGAGGTCAGAAGGGTCAGATAACAGAGATGCTGACTCAGGCACCCGGAAGACAAAAGCTCAGAAGACAGGTGGTGGCCTCCAGAGGAGCAGATGGCTCTCCTGGGGAACTCAGAATGTTTCATGGCACAAGTAGTAATACAGAGAGCACTCACTCCATGCCAAATGGAATTCTAGGCCCCGGAGACACATGCAGAATGAGGCTCCTGGCCGGGCGCGGTGGCTCAAGCCTGTAATGCCAGCACTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAACTAGCCGGGCGCGGTGGCGGCGCCTGTAGTCCAACTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGAGCGTGCAGTGAGCTGAGATCCGGCCACTGCACTCCAGCCTGGGCGGCAGAGCGAGACCCGTC 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@rCer/912/25_1732_CCS ATGGGTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGTTTTTAGTACATTCTGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTCCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTTGGAGGAGCGGAGGTGGCCGCCGTCAGCGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCTCCTTTGCTTCTCATTTTACTTTAGACAGTGGCCCAACTCCAGGCGTTTCCTTTCATTTCCTCAGTGCTTCTCTTCTCACCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGGGAACGGCAGGGACCTTGTTGGTATCTGGCTGTGATGGATAAAGAGAATCGGAGGCACCTTGTTTTCACAACTAGGATAAAAGTATCTGCAAGGTCCTTTCCATTCCTATTTGGAGGGAGTCCTGGCTCCATGGCCCCCTCCCCAGTGAACTGTCCAAGCAGATAGGCTCACACGAGAAACAGACTGAAAGTGGGGGCCATAGAGAGCGGTATGGAGTCCACGGAGAAGATACAGTGAATGCTTGCATGCATTCACACGTGTTTGTTACTGCTCTTTTGAGGCGGTGGTCCAGCTAGTTCACTCCTTTCACCGGGCGCGGTCAAGGCTCCCTCTCTGGCAGGGTGCAGCGAACGGCCAGCTGGGTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGCGCTGCGCTGGGCTGACTGCAGCGCTGACGCGGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTTGTGTTGATCTGTTCCTAGTATAGGCAACGTAATGAGATACTGTGCTTCCCACCTCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATTAAATTAAATCGTACTATGCAGAGCTGTCAGGAACCTTCTGATAGCCGTAGAGGACTGCAGCTGTCTAGGTCTGTGGCCACATCTTGGGACACACTGGATTGTTCCCATGTGCAGAGTTCAGCACTTACCTGGGAGTGCTAGGGGTTAGGCTTTGAGCTTGAACGTCTGTGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTCCCAATCTGTCCTATGGGGAGCAGTTTGGGGCGGCGGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCCGGGCCAGGGTGGCCTGGGGCGCCCAGAGGAGTGTGCTTAGTAGTTGGTCACCAGCTGTCACCCTTGGCTTTTCCTACTGTGTCTTTGTTAAAAGGCCTCAGCAATCCACAGAACTCACTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCCAAGATAAGAACCATTTGTGTAACACAATACTCAACTTCAGAAAGACATGCATTATGTGGTTGCAATCAACCCCGATGCTTTCAGATGACCTACTTACATCTTCAGTGTGGATAAGATAAGAACAAAACAAATGCATCTAAACTCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAATGATCTTTAAATAAAAGAAAACTT 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@rCer/914/1099_55_CCS CCCTGGGGGCTCCCAGGGCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTAGTTTGAGGTGTGACACCAGTTTGCTCCAGAAAGTTTAAAGGGGTCTGTTTCTCATTTCCATGGACATCTTCAGCAGCTTCACCTGACAATGACTGTTCCTATGAAGAAGCCACTTGTTTTAAGCAGAGACAACCTCTCTCTTCTCCCCTGCTTCATGAAGGCAGGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTTTCTATATAGCCATAAATGCGTATATATACCATAGGGCTAGATCTGTATCTTAGTGTAGCGATGTATACATACACACATCCACCTACATGTTGAAGGGCCTAACCAGCCTTGGGAATATTGACTGGTCCCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTACCAAGTTGACCCAGTTTGTCCTTTAGGTTAAGTAAGACTCGAGAGTAAAGGCAAGGAGAGGGGCCAGGCTCTGAATGCGGCCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTCCACTGAAACGTGAAGTCCTCTTTTGAATGCCAAACCCACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAACAGAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGGGAATGGCTTTGATCAATGGAGCCTGGGAGGTGTGCCCAGAAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTTCCACTTTTGACACCTTATCCTGATGTATGGTTCCAGGATTTGGATTTTGATTTTTCAAATGTAGCTTGAAATTTCAATAAACTTTGCTCTGTTTTT 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GGCATCTATCCAGCTGTGATCCTCTAGACTCCACCTCTCGCATCATGGATCCAACATTGTGGCATGAGCATTACGATGTGCCCCTGGGGGCAAAAAATCCTCGCAGGACACAAATCCTCCAGGATATCATTGCATCCTGGTAGGAGAATTTCTGAGAAGACAAGTTGACTGTGTCCCGTGCACGGAAATACAGCGTTTTTTGTCTCAGCCATTCCAGGTGCTGAGTCTTCACAGGTCATATGGGGAAGCTGTACCCTGAAGGAGACCATCAAAGATTCCAGCAATTTGCAGGTGAATAGACACTCCCAGAAAGCCTCTAATGGTGGGACCCATGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATCGTCGTGAGGGTCCTTGTCCTCTGTACTGTCGCTCTTCCTTGCCCTAACCCAAAAAGCTCATTATCTTGTGGCTGCACAAGAGCCTTGATTGAAGATATATTCTGTCTGAACGGTATTAAGGTCCATAAAATGTACACCCT + S')&$($($')($$%&$%'$()()(&%&%$&%&()((')())'(%'$$$"#(')(%$'*$%*,(#++)),(*(*-,%(%*$*'"##%&#"'&**),-+())%,,')$$%#*()*%#,*-.,%&('+**()*,((*#%#$(()"'(#'&")'%'-+%(-'(..,(&-+01+.&()+..,.,..'#+%+-(-/+0./&,--/.-.000,+,11.2.,*'*'*-+,*&*,-0+'(),0-*,0#$&0.,/2,+&%+0+.)+,%/*100,-10),(-+$)'+'-,)+$#(-+$++(,+,%)'%$)#$#++--''$($$$&#'&%$$"&($'***--+##&))(',,',),--%,)$(,,,-+$''&'$#$)*,*+'%)&&&.#$+&+/*-(-02+)(+(1)*&*(+/&*(&#%$%#$%)''%"#%&''))(#)$#'(,((+%,((%$#%'&,(,))-,)*,--+.,-)(),&(-*+**)&#'&&))+)--.,$&)$$-+-*&$'*"#&*,-('%&(%#%,$ @rCer/917/0_1617_CCS GAGCGCAGGCCGGCGCAGCAGCTGCGGGCGCACAGAGGCCCGCGCTCCTAGTCACTCCTCCCGCCTCGGCGCGCTCGTTCCGGGCAGCGGCCCGGGCCGGCTGCGGCCGCCGCCGGCGCCGAACTTGGACTCGGGAAGCCGGCAGACCGCGTCCTGAGCCGGAGCAGGGCATGGTCTAGCGGCCCAGTCAGGACACACTCCCGGAGGTTCTGACCCACTCCTCTCGGACTCCTCCTGGTCTCTGGTGTAGTCGCCGCCGCCAGCCGCCATGGGCAAGCAGAACAGCAAGCTGCGGCCCGAGGTGCTGCAGGACCTGCGGAGAACACGGAGTTCACCGACCACGAGCTGCAGGAGTGGTACAAGGGCTTCCTCAAGGACTGCCCCACCGGCCACCTGACCGTGGACGAGTTCAAGAAGATCTACGCCAACTTCTTCCCCTACGGCGACGCTTCCAAGTTCGCCGAGCACGTCTTCCGCACCTTCGACACCAACGGCGACGGCACCATCGACTTCCGGGAGTTCATCATTGCGCTGAGCGTGACCTCGCGGGGCAAGCTGGAGCAGAAGCTCAAGTGGGCCTTCAGCATGTACGACCTGGACGGCAACGGCTACATCAGCCGCAGCGAGATGCTGGAGATCGTGCAGGCCATCTACAAGATGGTGTCGTCTGTGATGAAGATGCCGGAGGACGAGTCCACCCCAGAGAAGCGCACGGACAAGATCTTCAGGCAGATGGACACCAACAACGATGGCAAACTGTCCTTGGAAGAATTCATCAAAGGTGCCAAGAGCGACCCCTCCATCGTCCGCCTGCTGCAGTGCGACCCCAGCAGTGCCAGTCAGTTCTGAGCGAGCGGCCCCTGGACAGTTGCAGAGAAACACAGGCTTGTCGTGCCGTTTAAGCTTTGCTTGCAAGAGTGGATGCCCCGCAATCGTTCCTGCTCTCCCGGGCCCCAGGCCTGGGGCATGCGTCGCACCTGCCCGGCCCGGCGGCTGCGCCTCCCTCCTCCGCCTGACCAATGCGACATTCCTCCCCTCACGCCCGGCCCGGTCCCTTCCAGGGCAACTCCAGGGATGTGATGACATGCAGGGTTCAAGTGTTCTTGGTTCCAGGCACCTCCCGGCTCATGGGAGCCCAGAGGTCCATGCCGAGGAGACCAGGCAGGACCTCCCGAGGCTGCGCCCCGGCCGGCCCATGCATTTTGTGATCCCAAGTGACTCTGTGGGGAGGGTGGGGCGAGGCGTCAGGAGGGTAGACGGGGAGCCCCTCCCGTGCATGGCTGCCCTCCCGTTCATTTTCTCCACCACAGCCGCTTGCACGTATAGATACTGTGGTCCCTTTCTTTTAATATATAAATTATGTATGGTGAAGTGGAGTGTAATGTGTAGGTCCCGTATTTAATGCCTCTGACTGCCTTTGAAGCGCAGCCCCTGTGGCCCGCAGTCCCCTGAGCCTGGCTGTTGTGTGGTATTTATGCTCTCTTTGTCTGCCTGTTTCTAAGGAAATGCATGTGTGCCCTGAGCCGTGACGATCCTCCTGTCCGTGTCGCGAGCACAGGCATTTGTGTCTGGTCTGTCCTCCCTGTTGATTGGTCTGGCATTTCCGGTATTAAAATG 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rCer/924/25_2160_CCS ATGGGGCCTGTGATTGGCTGCCGGCCCGCCGTGAGGCAGCGGAAGGGGTTGCAGTGGCCATTGGTGACAGGAGGTGGGGCGGCAGTCACCTAGGCCTGGACCTGCGGCGTCGGCTGCGCGCGCAGAGTGCCCGGCGGGGCGTAGAGGCCGGGCGGACGAGTGGAAGCTGCGGGTATCCAAGGCGGGGCCTGGCGCGCAGGCGCTGACCCGACCTGGCAGTGAGGTGGCCGCGGCCTTGGCTGAGAGGCCTTAACCCCGCTGGCCGCCGCGCCCTGCATGCGAGTTTGGGCCGCGGCGCGCGGCAGGAGCCTACTCGGGGCGGCGGCGATGGACGCCTTAGAAGAAGAGAGCTTTGGCGCTGTCTTTCTCCTCCGCCTCTGATGCAGAATTTGATGCTGTGGTTGGATATTTAGAGGACATTATCATGGATGATGAGTTCCAGTTATTACAGAGAAATTTTCATGGACAAGTACTACCTGGAGTTTGAAGACACAGAAGAGAATAAACTCACCTACACACCTATTTTTAATGAATACATTTCTTTGGTAGAAAAATATATTGAAGAACAGCTGCTGCAGCGGATTCCTGGGTTCAACATGGCAGCTTTCACCACAACATTACAGCACCATAAGGATGAAGTGGCTGGTGACATATTCGACATGCTGCTCACTTCACAGATTTTCTGGCTTTTAAAGAAATGTTTTTGGACTACAGAGCAGAAAAAGAAGGCCGAGGACTGGACTTAAGCAGTGGCTTAGTGGTGACTTCGTTGTGCAAATCATCTTCTGTGTCAGCTTCCCAGAACAATCTGCGGCACTAGGTCCTACCTCCAGCCAATGAATGGGATCATTCTGGATGTCACCAGCCCCATAGGCCCAGCTCATGATGGCAGAACACATCTTGGAAAGACTGACTCTGTTATGTAACTCATTTATGTTAAGTATTGATAGGTCAAAACCAAAAAGACCTAACCCTCCTGGACCTATTGCTCCTGAAACACCTTCTTGTATTCATTAACCATAGTACTCCTCCCCTCCTCAAGTAGACACCTCTCTCAGGAGCTTCTGGGTCAGACGCCTCTGGAGCGAGCCCATGTCAAGCACTCCCCTGGGGCTCCTTCCCCAGCATACCTGCTGGTGTGTAAGTGTGGACTAACCCACCGCCACCACCCTCTGTTCCAGCAGCCTCTGCATGAATCTTTGTGCACTTGCACCTCTTTTTCACATGGGCCACAGTTTCAGTACTGCAGCCGCAGTGGGGTTCCTGATGTTTATCTAGGGTGTTACTCAAGCCCAGCTTGAGATTTCGGAATCTCCTGTGATCACATCTTGTCTTGGCTGTAGGAATCAAAAGAAAGAGATATCCTCTACATAAAAGCTCCATGTGAAAAGCTACTCCTAGTCTTAACATTTGCAGTCCTTGTGTCACTGTCTTCTGGTCCTGATGTAGTCCCACTGTTTCTAGATGTCTCTTTTTAGCATTATTTTTGGAAAAAAAAAATATTTTTATAGATGAATACTCAGGCTAACCTAGTGGATATGATCTTGGAACTTCCATGATTATCCACTTAAAGATCAAAGTATTATATGCTGTGTGCTTTTTAGGTGTTAGTACTGTGAAAGCAAAAACGCTTTCTACATTGGCATCGTTCCTATTTTACTGGGCACCTATGAATGTATGCTGTGTGCTAGAAATAGGCTAAAACATTCTTATAGCATGTTAGTATGTTTGCATGTTTGCTGAAAATCCTTTCTGTGTAAACAAGTTTGTAAGGTTCTCTGGGTTAGGTAGGGACTCTGCAGTTTCTTTCCTGTCAAAATATCTCTTACTAAGATGATGTTCCACTGTCCAGCCCAGCATGAGTAGCAGGTAGGGCACAGCTTTACTGGCTGTTTGTATGCTTTGGTTCAGTGCAATGTGTGGTAGATTACTTACCAGAAACATATATGTCATCTCTAGAATGAAGAAAAAGCATAGTAGTTCAATTCCCAGTGTATCCCTTTGATTTTTTTAATAGTAAAAGAATCTGTACTGACTTTTCACTTGGCCATTCTGGTTTTAAAGGACAAGCTATAAGCTTTACATAAGCTCTGTTTTTCTGTACTGATGTGTCACTTATTAAATACTTTTGTACC 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@rCer/925/25_1714_CCS ATGGGCCATGTCCTGAGAGCAAGGTGGGGCCCTGGACTGTCTTGTATTGGCCCCAAGCCTTTCCTGCTGTGAACAGCTTCATTCTCAGTCCCTTTCCTGGCTCAAGAATTGACCTAGCAAAAGAGAGGCATGGAAGGAAATGCCCTCCCTCCTTCTGCAGGCAGCCACTCAGCTGTGCTTCAGCTCGGTGCCTGGTGACAGTTGCTATGGAGATCTAAAGATAGAGCAGGAGTCAGGAGACCTGGGTCCCTCTCCAGCTTGTCCCACTCAGCGGCTGCCGATCCCGGTCCACCACCCCAGAACCCGGCACCCCATCCCAGGAACCCAGTGCCCCTGGCAGTGCACTGCAGTTAATGAATTCTGCTTTCCACAGCCTGGGCTCCAGCATGCTGCACCAGCTTGGCTAACTACAGGCAGTCCCAGAATTGGAATACTAAGCCATGGAATCTTGGAGTTAGATGTTTATAGTCATAGAAGTGTACTCCTCACCATATCAAAGCTGAAAGTTCAGGACTCTAAGAAACATACAGTGTGACAGACTTATCGTATACACGGGAACTGAAGCCCAATGAGACTAAATGATTGCCCAGGTAAAACAATCCATGGCCGAGCCAGACTAGAAGCCTCCTAGCTTCAACTCATGTGCCAGTTCGGCACCAGTGGTTTCAAACTGCGCTCCACAGGAAACAAGCGTTCTTTGCATAGCAGCAGTGAAAGGACAGCTCCGATGGATCCCAGACCCCCTTCAACCAGAGCAGTTCCGTTTTCATCCATTTGTATATTGGGGTTTCGAAGTATTTTTATTTGTAGAAAAGGATTTCCTATCCTGCTCAGAAAAATGGCAACAAATCTCTCTGCTGTGTCACATTTAATAAATAATTGTGACATACAGCTGGGGATGGTGCCGGAGGTTTCAAACTGCTTCACAGGCAGAGTTCCAGGTCAGAGAGCATGGAGTGCTGTGTGTGACCTTCTCCAGAAGCGTGGGCACAGGAGCGTGTTAAAGGCCTGAAAAGACCAGTGGCAAAGAAACTCCTTTCATTTTGTCTAACCCAGAGTTTCTCAAGCTTATTTAACTATAGAACACTTTTCTATGGGTTCATAGCTCTTTCTAGCACAGCATAATGAGTGGGAAAGGCCCTGACTGAGAGTCAAAGATTCTGAGCAGAACCGTGATCTCTTCCTGCCTAGCCTGTGACTTGAGCAAGACACTTTTCCTCTCCCAGACCTCTGAGGTCTGCGATTTTCCTCCACCCTTTCCTCTCCCTCAGTTTGCACGTCTATTGACTCAGCTGCAAATAGCGGGGCCTGTCAGGAGCCTGACTCTGTTCAGACACCAGGGAAACAACAGCACACCAGGCAATGCAGTTATGTCCAGTGCGGAACTTACAGCCTAGCAAGGAAGGCAGAAATTCAACCTGTATTCTAAAAGGATAGATGTCATGGAAACGGAAGTGTGGAGTGCTGGGAGAGTGGATGCAGGGCTTAGCCCAGTCTAGGGAAAGGCCAGGGGCACACCACTGCCACCAGGGATAGAGCTTCAAAAGCTTCCAAGTCACTCATATTAAGAGTGTTGCCAGGCATGGTGGCTCACACCTGTAATCACAGCACTTTGGGAGGCTGTGCAGGCGGATTGTCTGAGCCAGAAGTTCGAGGCCACCCTGGCCAACATGACAAAACCCTGTCTCT + 374<:)34768.95-92:<2.9-;0)3:9)79<<;99198-(87<4.8)9&<5--<32?3;8'48960/771>-50:4?784;47;863%:;,>=(882578<1?;2:3<10"59784*688,#02,9(15*73=+479;76(602()53),)5+-,&2&44/((/006:5;)656(&5?=21594#*+#+:9(72-1/29(1440/8362736;*,2:6737*8813+:3<=88%3233'86'063.;5./0-21115;+3+9845789==2=<<=*;994*9='544:7&&:9;)9212:(:;8*8(3,:=1=;9-<<<8&=<68:752):<<8<9::;;:,;5;-096'=60>8:7;3>257>25.3496,1;99:+2/8872)/(3/5/::8.65'994085=?58-64=3;2:65.00<0&:8738097;+<49206;::9+$,6-,268>1982:0:8289998+9580+68-55<,:4:=;<*=8/'531/6/3729(83-9<8-87:156187397<36&)/46=75/4886/8*$8595.2:'=;9>79=<4;3*?6.7/#04'3-(%.(/74=74:95>.3.65=672,<6-$'.:659+-:9(978473=908'5:96;916<57/:6,7/-+77)7%&&7::6<=677;763.;4986:1<=:3;8=:/:2(<<;6.$$485,667/8-=<)<<<7(7<(:<6:*::4$86*/4(00<=<9<59,,4986879+8/;90=<<588%76);9//0,--6+;11)>=<65:4)7-<>=;5,<9/402/?>:+20%;=(/<<:5918;:8:<*<7<;15<(7?<-97-5243381.483.8;<:9/><'72%96//4/169;8)063:41*4%26516&,,.(84:14=/=>:/8<92711?1:9;4?694053=3;2&78=03/.138<9-80%4;/151(*-0,0+74:<6'80/4<67<;+9:7788595)59772653<0715:<'97=<8:>/;6)77-=;*%::09+305703'86427994;0>8684:(825393;8)5960=23:<33:55*<36.+;8:9890/>-#<#+283&-;+6;9:6854*141475;88:967?81?;.>8:49==<;:8,:+3:.>>:<+;9<=<2;<+0:0-0=9754/+6>97==1;:<.,;48484:/832*728:-(43*><:'434.(:=;92):=61552;486<=:5+=>8*=7)6,7:?2>74?611-469;883>>6=;895'14);;8.794=:273*8<;9:<';,0-5699984545'89:3)0(-75='99,(-/28)432??/0>67;:65;;77=:8>0<;:=2528(3.%7::?63/<04<8=1:9)57'3,:::5&/4/5&896&=1:;/:9405-/+5.=:./627//9/(-8%/++6%3486528262)$21(768*6.4-:20+0.6018<3>=350:7(;85-4;:.3.984,5.,:719966677)9.<;&;9559191;39,,&+,4&-09:?6>73<7.)80+653478=3>5&35799:/;?5;===4896,<66,3??)<23*91*69$9-.9;)561345+)654+;::6=63=7764>/>9*9664=(34>6103,'$343)82.306.77 @rCer/928/1834_57_CCS ATGGGAACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCATCGAGCACGGCATCGTCACAAACTGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCGTGCTGCTGACCGAGCCCCCCTGAACCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGAACGGGGTCACCCACACTGTGCCCATCTACGAGGGTATGCCCTCCCCATGCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCGCTGCCCTGAGGCTCTCTTCCAACCTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAAGCCACCCACTTCTCTCTAAGGAGAAATGGCCAGTCCTCTCCGAGTCCACACAGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTGTCCCCAAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACAC + /+)/##%.'24)/55321052*+*.++*)*//57129:7989+80602:8+9:9;ABC629):A?;7>560328*9(4<003:43BE=<5=88-*281)$2//<6<9@:C:6@:4;?44;-6<2?@;=@E8B7@ED?<10?/:;@*B?:>=5A?A=/D9:C*;A<8?A8B>?0:99=-1;=>>-:@4:1C86CF9;:2=2;D@D89%<;>>@9:=@?<'88:@&;5?B8<;@A2@<485&<.=$><8:?<85';;7?2/4C0D><1;8:6>/=8498;::5@8;363$%3$A;>'7.:<8<>:,>+B<<8$:;<1';62>6><6;4>29;=1.29;=B@;96*6;.387'<996/418023$7;<=?;:0:06230'2:A:6178<;;92?99(/,B%"#5/3>:705=4<=>58=:-8)=B958$3B93%65<<6648<>0>=>55;888/8?CB48<3;0@=,<;46'A:1675=&=B:=:A;206<7&:/7;60/57BC<@7@?>224??9:6>:56964;0.@@>1;/-5;36&5947/:65$475;:A<38:'@:7<87&4673#4/8%?8B;:<=312:B>B>;-60>=97@,55&6B=B;8;@3&23'-4.+*/5>:?;9=<>>9;<=0<9>(;-=9.284%6=17<=:-8?27::+:&CDA?E@?0>?62;:;;=@CBE>@0@>558:3D=?5EA=:9EAA@E6=B@?/@A>/=75>DB0<@9/;<=>9;)=;-;:*DA9<6@A>A0C?48?>9C=96.$6:94C=2BDA=1@7?>5E4C9B>:/$9<<:;1>GG7E?C@5;49<)9>:D8AA9?5$819?>=>>@;:>>9DBAG@<68:>@3DD5545(7A<1<;@4@3>E:<=A@E4?5D@D6EF977@,?E?>@81>?';<2;;GB>8:<@?@EB=@8?4AF6/.94+=9A>71>A7D?>:<CA:=?3>9:4>>1=31.++=9>&C@8;0EFBCE9AF@?88;=4:9<7??:?CA@/86(1817A@57&4222*+;>9>@1:D6EDBC=D26>>FD5-55A:07=EA@?,;0@51?BD7;->A0A?A?+>F;AB:@8@3?>*>:5C5@E8B5<:073>A=21-,8A/@C3?>?:A@=<;%938=:=??72?;'7::?/A77=;A>B?<9+;>?7'+9;@&$">88;8::??@$;;;<+73989':?>(;:@B@B,A9;(66A@>=;11==:>B<5%B;20:$00/=>=D>=90A/=@?9>3FA8E;B12&(=EC@BA3AEAA>;DC*@7AC4BEEE=F?A5):90=@@DC8<:?7@A2<;<;5A8367:&@3@AA(D<3;:=;B';=+;A>%:<@4AEEFFCGBD:9<@?&A;+F$?A5A56A;A&D?=:C=.8/?DBB(9B<39C:B7>:;B2BB4;5<>@;?;;:3>B?%'3<>A:$@1EAF==?AD9*65<<=?><&=D?929@D=-5>><1DE9?C1<;?=?.C>95;858/&5/F:DA:@:,ABBF5A=FA<%;8AG:EFC8@B>CF?@=B<877>:CB?8=2410'?2A<&45>:0 @rCer/934/25_1698_CCS ATGGGGACGCGGCGTCGCCAGGAGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACTCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAATGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCCAGCCACTCCCCGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCT + HE:JJIEHIIED:>@CDA>;85=$;@CA?DAC?A@6A?BG?CGFGHC5C9>GIC@E@=CG>D3G@+;C?FHEGFG;<@H0@@HHI@GIE9A<<@JJJIGJEDID8=<@<=,EECEGEG@EDEDFF:CEEEHHGGHFGCBBE.C>FCEBHA>C0F+CD0GE-@>9BGCGDIDEIC-E?=@2>H>?A@>;3ECBAIBE>@FFHH9FECBHH@EIIIEICBF?HG>FCACEFFBCFHFCICEIGHFFB;B?GGHIGJ=AHC=D+G@>EDE>?D>A=BEGHI>6CHDBBD:H7DCE=>3DB6H>FIAF;IDEIDEFEIJAJHKGHIG=GKJHCI@HI@F@GIHGKJFJ*J=6>@IJGJBJDKH4BGHGHKJJEJGDCHHIAFAIEHFHBFJJE>AIKGEJIII?KHJHKCEEKHJ@IIJIEGIJJDDBCIGEKIEBHEAGJKJCHB;JKJKKCGKJFKJJJKKEHJJII@KCBGKKJHEGGAHCJJIG8KJJIKEKJBD;F?AF@C=HIGKEHEC4ED>H-G+FDEAIKHDCD<JHA5B:JHBFJHIFJKIJKKIGKJIIK1HHDJ>EIJHII?JFGB0F?CKIEKKKJJBIBGI.GEGJHEHIEEFJII6JKD?IHHGCKFFFHHIGBC8KGGEKD=D?CKHJH9@=JFKKIGIIDAC;<>JG=EDFED>F.A:4;GIKK@JHIFJJJKIGK4FFHCHKHJIICBB>:FJKKKIKK?KK=AFJ1K?2EIBJKKKJJJHJDJH>EJHHKKKIKJKFGAJIADJFFH5JJFKJHJKHFJJKHCJJHHKE@K>HK@KKKJKIFIJGFGHJKKJJKKIKEK/IAJ7KHJJECJJJJCKK?KKIJ%BK9KJJHI:FJIJJGKKHIA7KKKK=JJJHJHJHDJ@/FKIIJHJJJKKKKGKJHKJKGHKIKKDCHG6KJJKKGG7GKHC@@DIJFKIAJK9FKIHKKD:KCKHJGDJJ7JKKJIJ@JKGJJKJIKJJJJKJKKJ@KHIK?KJKIJKKKKKKKJEJ,KKHJJ>KKKKKKJ6JHJHH6JJKKKKKJKFJKGJKIJJHKGJJKKC:HKIIJ?JHHGCJJIKKIIKKKKJ=JGKGJJJIKKIKJGFJJJIHEBFFGICKI,FKDCHHFJAIIIJKDGJ @rCer/936/1095_56_CCS CCAAGACTCAGAATTAAAAAAAAAAAAATGGATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAAACCATTCTCACTGCTCTACATGCTGAAGAATCATCTGAGGGGGAGGGAGATGGAATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTTTTTATAGCCTTCCACTGTTAGAGATTTGAGGTTACAATGATATACTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGGATTATGCATCAGCAGAACAGAAAATGTGATGTTTTTATGCATGTCAATAAAGGAATGACCTTTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAACACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTCCAATACACTGTTTAATATAGCACTGAAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTATTTCTTCAATAAGTTGCATAAACCAATGAGTTAGTGCCTGGATAATCAGTATGGGAAACAATCTTTTGAAATGCAAAGCTGTTTTTTGTATATACTGTTGGATTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTCGAAAGAGTGGATATTTTGCCATGTTCAGTTAAAGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAGCTATTTTGGATAGTGTAGCTTTAATGTGCTGCACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTCTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTTTCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAAAACATAACATGGGAGTAATAATGGGTCAAAATTGCAAAATAAAGTACTGTTTTTGGTGTGAGTTT + &#()*,&('#-.--%'%*((*+*%'')#'$"#'(&)&(+(&)++(&$%%%()-&.**),+),-)+-*-()&*'%+(*),+(&&%''#,)#'+%(%$(((&#%+)))'++)&'#+)++%),',()*%*),'),,+,&&%$&(''((((,-*,,(&&++&-,-*-+)**,*,,,)*()*,(()--,--,,(&#$(+&&#'--*+',',,*(,++,-,).-+',-),(,)$"$*,'(',(*+(+'++$((&,,+()),,'+(,-.-+&-+,'-*),,*&&)(#*$&)(&(,,),-+((+(&(*&*(+(*'%#&,-)*--,+))*)-),-*).),,*(,*%#%&%*,&,,)(+'),*-)-'-.-..--,.-*+,++'*#+*-,(-.(,-,'#%$-*-)-,*,),--,-*('++))'&&*),,-)-(--&(#&*&+---)&(*&&-)*,,)(,+'%((-**'&'&,+)-*)(-*)),*(+)(,)-'%))(&,+''+''%(--))*)*&(+))+((-,.-,,)-))*,),)(,.---*(',---)-,**((''$-))(,-+&+,#+)',,**+#)-*'),'(-)-)-')*,)'###+-.+(&%&#'(',-*,,',*&-,,--)+(),*)$'-&'&%+.+--)$+++,/'-../-..+,/1)-%,0&/1.0--2/*-,%$$01/'/.+2)*312+2.44--'.1-3+05/05*+(,022*45*-*,5)..232321/*12111(((36604203*3'22,23*240.3.2020,.233)/+151+/+,'1,.$//00,-/#6/%104662...40-521.0+.1.-)1-,--+,,--+,+-+/&,,01.2,-0*%-...*000*---.%..*&0*,&/2201.11,...'/2,.02/*00-/2,121,2./,.2..1-0,-./*(+21-)..-0--*)+,/-*0.-,1.2111002-1011-.2.,)&))/,'++,-/+),,$..,,++*121)*+.+/-+)02..0-//+&1'0.0/-+/-,%-.)/*.--..$1&%.'%30-"# @rCer/938/2222_56_CCS ATGGGGCGGGCGGCGACGGCTGCACCATGGGCCGGCTACTGCGGGCCGCCCGGCTGCCGCCGCTGCTGCCGCTGCTGCTGCTGCTGGCTGGAGGAGCGTTCCTGGGTGCCTGTGCTGCTGGGTCTGATGAGCCTGGCCCAGAGGGCCTCACCTCCACCTCCTGCTAGACCTCCTGCTGCCCACTGGCTTGGAGCCACTGGACTCAGAGGAGCCTAGTGAGACTATGGGCCTGGGAGCTGGGCTGGGAGCCCCTGGCTCAGGCTTCCCCAGCGAAGAGAGTGAAGAGTCTCGGATTCTGCAGCCACCACAGTACTTCTGGGAAGAGGAGGAAGAGCTGAATGACTCAAGTCTGGACCTGGGACCCACTGCAGATTATGTTTTTTCCTGACTTAACTGAGAAGGCAGGTTCCATTGAAGACACCAGCCAGGCTCAAGAGCTGCCAAACCTCCCCTCTCCCTTGCCCAAGATGAATCTGGTTGAGCCTCCCTGGCATATGCCTCCCGAGAGGAGGAAGAAGAGGAAGAAGAGGAAGAGGAAGAGGAGGAGAGGGAGAAGGAAGAGGTAGAGAAACAAGAAGAGGAAGAAGAGGAGGAGCTGCTCCCTGTGAATGGATCCCAAGAAGAAGCCAAGCCTCAGGTCCGTGACTTTTCTCTCACCAGCAGCAGCCAGACCCCAGGGGTCACCAAAAGCAAGCATGAAGACTCTGGGGACCAGGCCTCATCAGGTGTGGAGGTAGAGAGCAGCATGGGGCCCAGCTTGCTGCTGCCTTCAGTCACCCCAACTACAGTGACTCTGGGGGACCAGGACTCCACCAGCCAGGAGGCGGAGGCCACAGTGCTGCCAGCTGCAGGGCTTGGGGTAGAGTTCGAGGCTCCTCAGGAAGCAAGCGAGGAAGTCACTGTGGGAGCAGCTGGTTTGTCTGGCCAGCAGGAGGAGGTGCCGGCCTCGCCTTCATTCCCTCAAACCACAGCTCCCGGTGGGGCCGAGCACCCAGATGAAGATCCCCTTGGCTCTAGAACCTCAGCCTCTTTCCCACTGGCCCCTGGAGACGTGAAACTGACACCTTCCTCTGCTACCTTGGGGCAAGAAGATCTCAACCAGCAGCTCCTAGAAGGGCAGGCAGCTGAAGCTCAATCCAGAATACCCTGGGATTCTACGCAGGTGATCTGCAAGGACTGGAGCAATCTGGCTGGGAAAAACTACATCATTCTGAACATGACAGAGAACATAGACTGTGAGGTGTTCCGGCAGCACCGGGGCCGCAGCTCCTGGCCCTGGTGGAAGAGGTGCTGCCCCGCCATGCAGCGGCCACCACGGGGCCTGGCACATTTCTCTGAGCAAGCCCAGCGAGAAGGAGCAGCACCTTCTCATGACACTGGTGGGCGAGCAGGGGGTGGTGCCCACTCAAGATGTCCTTTCCATGCTGGGTGACATCCGCAGGAGCCTGGAGGAGATTGGCATCCAGAACTATTCCACAACCAGCAGCTGCCAGGCACGGGCCAGCCAAGTGCGCAGCGACTACGGCACGCTCTTCGTGGTGCTGGTGGTCATTGGGGCCATCTGCATCATCATCATTGCGCTTGGCCTGCTCTACAACTGCTGGCAGCGCCGTCTGCCCAAGCTCAAGCACGTGTCGCACGGCGAGGAGCTGCGCTTCGTGGAGAACGGCTGCCACGACAACCCCACGCTGGACGTGGCCAGCGACAGCCAGTCGGAGATGCAGGAGAAGCACCCCAGCCTGAAACGGCGGCGGGGCCCTCAACGGCCCGGGAAGCTGGGGGCGCTCATGGGGGGCAAGCGGGACCCCGAGGACTCGGACGTGTTCGAGGAGGACACGCACCTGTGAGCGCAGCCGAGGCGCAGGCCGAGTGGGCCGCCAGGACGAAGCGAGGTGGACCCCGAAACGGACGGCCCGGAGCCCGCACCAGCCCCGCGCCTACCCGGGGCCGCTCCCGCAGCCTGGCCCTCGGCGCGGGCTCCTCCCCGCTTCCCCCGACTTCACACGGTGGCCTCGGACCAACTCCCTCACTCCTGCCCGAAGGGCGGGCCTCAGAGCCCGCCTTGGCCCCGCTTTCCTGCCCCTGAACCCCGGCCCCGCGGGCGACGGGCGGCGCTCCCTGCGCCCCAGGACTCCATTAAACCTGCCCGGAGACCACGCCGGGCTC 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@rCer/939/1886_60_CCS ATGGGGGTCAGGCCCGGGGCGGGTCCGCGGCCGCGGCGGGAACATGGAGGAGCTGCTGAGGCGCGAGCTGGGCTGCGGCTCCGTCAGGGCCACGGGCCACACGGGGGCGGGTGCATCAGCCAGGGCCGGAGCTACGACACGGACAGAGGACGAGTGTTCGTGAAAGTGAACCCCAAGGCGGAGGCCAGAAGAATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACAGTGAGAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCAGGCGGTGGGAGCGTGCTGGTGATGGAGCATGTGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTACACCTTGAGAACAAGAAGCGTGGAGAGACGCTCCTGAAAGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTGGACCAGTTTGGGTTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTTGTGTTCTATGCCCGCAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATCCCTGACCTGTTCCGTGACCTGCAGATCATCCCAGCCTTACTCCACGGGGATCTCTGGGGCGGAAACGTAGCAGAGGATTCCTCTGGGCCGGTCATTTTTGACCCAGCTTCTTTCTATGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGCTTTAGCAGCTCCTTTTACTCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTCACTACCTGAACCACTGGAATCATTTTGGATCGGGGTACAGAGGGTCCTCCCTGAACATCATGAGGAATCTGGTCAAGTGAGTGGGCCTTGCTCTGGAAGGGGCCTCAGAGGTTTCTCCACAGTCCTCTTCAGGGCACATTCTTGTTTCTTCACGTGGCCGGAGTAGCTTTAGACTAGCGCAGCAGCTTATTTCCAAGCCTTGCAAAGTATATAACACCTGAGAGGAAAGGTTTTGTCATCCCAGCGTTGACCACTTTGTGGGGGTTTGTAGGTGGAGGGAGCCGCGCTGGAGGCAGGGTGTGAACAGAGGGCTGTGTGGAGTGTGGGTGACTCTGAGCCCCACTGCCGCTGCAAGGTGGAGAAACTAAGTGATCTCCCGTGGGGCGGGAGAGGGTGTCTGGTGCGCAGGGAGGTGGCCGGTGCTCCTGGGCACTGCTGCTCGTAGGGCACCTTCCCGCCACTCCTCCCTGCTCTCCTGTACCGGAGTGTCTCTGAGCTGCTCGTAGGGCACCTTCCCGCCGCTCTTCCCTGCTCTCCTGTACCCAAGTGTCTCTGAGCTGCGTGTCTCTGAGCTGCTCGTAGGGCACCTTCCCACCGCTCTTCCCTGCTCTCCTGTACCGGAGTGTCTCTGAGCTGTCTACGTGGATGCTTCTTGGTTGGCCAGACTTGGGCGTAGATGTGAAACCATCTTACTAAAAGCATCTTAAAATGACCAATTCCAAAATCAAGCATATTCCCGCTTCTTCCTGCATGATCCCTGGGCTCTGCCACAGGCTGAGCAAGTCTGTAAACGGATTCTGGGAGAGACCAAGCCGCTGGCCGTAGGGTGTCCGTGGGTAAATCCAGGAGTCTTCATTGCTTCTGTTATGACCCCATCTCTGCCGTTTTCTAAAGCTTGCTGAGTTGTCATTCCTTTGCAACATTAAAATACGTGCTG 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@rCer/941/2787_67_CCS ATGGGGAGCTCGCCCTGTGGCTGCTCGGTGGTGGGTGAGGGATCAGCTTTTCTCTGCTAGTTCCCACCCTGGGAGTCCTTAGCCCCTGGAATGCGAGAGGGAGATGCTTAGGGAATTTCCGAAGTGGGGCGTCGAAGCATCGCCTGGCAAGGCCTGGGAGCGAAAAAAGATCCCTACTTCGTGGAGCCGTTGGAAGCTACCGGGGAGCCACTGGTGGGGACCTTTTTTGGGCCCCCTTTCCTTCGTGGGGTACTATGGAGTTCCCAGAACACAGTCAGCAGCTGCTGCAGAGCCTCCGGGAGCAGCGGTCCCAGGGTTTCCTTTGTGACTGCACCGTGATGGTGGGTAGTACCCAGTTCTTGGCCCATCGGGCTGTGCTGGCCTCCTGCAGCCCATTCTTCCAGCTTTTCTACAAGGAGCGGGAATTGGACAAGAGGGATCTGGTGTGTATTCACAATGAAATTGTCACGGCCCCAGCCTTTGGCTTCTTCTGGACTTTATGTATGCTGGCCAGCTGGCCCTGAGAGGGGATACCCCTGTGGAGGATGTGCTGGCAGCTGCAGCTACTTGCACATGAATGACATCGTCAAGGTGTGTAAGCGGCGGCTTCAAGCCCGGGCCCTGGCAGAGGCAGACAGTACCAAGAAGGAGGAAGAAACCAACTCACAGCCTCCTAGTTTGGAGTTTTTTGTCCAGTACTGCCCGTGGCCCCCAGCCTTCGTTGTCATCTGCTGAGACATCAGGCCATTGGGGCAAAGGGGAATGGAAAGGCTCTGCTGCTCCCTCACCTACTGTCCGTCCCCAGATGAGCCACCAATGTCCAATGGGGCTGACACTACACAGCCTGGCATGGAGGTTGAACACACCACATCTGCGGGCACCTCCTCCACCGGTGGCTGATGTCTCTCTTGCCAGCCCTAGTAGCTCCACTGAGAGCATTCCTGCAAACTACTACTCTTCTGGCATCCCAGCAGTTTCATTGGAGCCACTGCCAACTCTTGATGTGGGTCCTGAGAGTCTGAGGGTGGTGGAACCAAGGGATCCTGGAGGACCACTGCAAGGCTTCTATACCCCAGCCTCAGCCCCCAGCTCAGCCCCAGCCCCTGTCTCAGCCCCAGTTCCATCCCAGGCTCCAGCCCCAGCTGAAGCTGAACTGGTCCAGGTGAAAGTTGAAGCTATTGTGATCTCTGATGAAGAGACCGATGTGTCAGATGAACAGCCTCAGGATCCTGAGAGAGTGTTTCCCACCTGGAGGAGCAGTGTATTGGGGGACAGCCCTCCCAGCCAGAGGCTTTTGAAGACTCAGGGGCAGCAGGACTGGAGGAGGTGGGGCCAAGTGACCACTTCCTGCCTTCAGACCCTCATCTACCCTACCATCTGCTGCCAGGTGCAGGGCAGTATCATCGAGGACTGGTGACCTCACCCCTGCCTGCGCCCGCATCCGTGCATGAGCCACTTTACCTGCCTTCTGAGTACGAAGCAGGTCCAGGAAGCTTTGGGGTTTTTACTGAGGATGTTCCCACCTGCAAGACATGTGGGAAGACCTTCTCATGCTCTTACACACTACGGCGACATGCCACGGTGCACACACGTGAGCGACCCCTACGAGTGCCGCTACTGCCTGCGGAGCTACACACAGTCAGGGGACCTCTACCGCCACATCCGCAAGGCTCACAACGAGGACCTGGCCAAACGCGCAGCAAACCGGATCCAGAAGTGGGACCCCTTCTAGGGGTGCAACCTCTCCCTGGCTCTCCAACAGCAGACAGACAGAGCAGCAGTGGTGGAGGGCCACCCAAAGATTTTGTACTTGGCCCCAAAAAACTAACATCTAAGGAGCATGAGCTGACGCTAGGCTGCTCTTACCATCCTTAGATGGCAGCTCAGAAGGTTGGTGGCATCTCATCACCCCTGCTCGGTGACAAGAATAAAGGTTCTGCCCAGGCTGAAAGTTCCTACCCTTTTCTGTTTTTTTTTTTTTTTTTTTTTAGTTTTTAGTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGTTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCAGCCTTCTGGGTTCACGCTGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGGCCATCACCATGCCCGGCTAATTTTTTTTATTTTTTAGTAGAGATGGGGGTTTCGCCGTGTTAGCCAGGATGGTCTCTATCTCCTGACCTCGTGATCCGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCGGCTGCTTTTTTTTTTTTGAGACAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCAATTTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTTCTCCTAACTCAGCCTCTTGAGTAGCTGGGATTACAGGAACGCACCACCATGCCCAGCTAATTCTTGCGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCCCAGGTGATCGCTCACCTCGACCTTCCAAAAGTGCCGGGATTACAGGGCATGAGCCACTGTGCCCGGCCTCCTACCCTTTTCTTTGCCCAGCCAGATAAGCAGGACTCTGTGGGGCAGAGATATGACAGCTCTCTCCAAGGGCACTGGGAATTTTCCTGAGGTATAATCGCTTCTCACTGTATGTTCTGGAACATAAAGCTAGGAATG 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@rCer/944/1806_59_CCS ATGGGGACGGACGCAAGATGGCGACGGCGACCATAGCTCTCCAGGTCAATGGCCAGCAAGGAGGGGGTCCGAGCCGGCGGCGGCGGCGGCGGCAGTGGTGCAGCGGGAGACAAATGAAACCGCCACAGGCACAGACTCCATCAAGATGAGAACGGGCAAGCACAGCCGCCAAGCTGGGGCTGCCTCCCTGACGCCTGAGCAGCAGAGGCCCTTCAGAAGGCCAAGAAGTACGCCATGGAGCAGAGCATCAAGAGCGTGCTGGTGAAGCAGACCATCGCACACCAGCAGCAGCAGCTCACCAACCTGCAGATGGCGGCTCAGCGGCAGCGGGCGCTGGCCATCATGTGCCGTGTCTACGTGGGCTCCATCTACTACGAGCTGGGAGGACACCATCCGCCAGGCCTTTGCCCCTTTGGTCCCATCAAGAGCATTGACATGTCCTGGGACTCTGTCACCATGAAGCACAAGGGTTTGCCTTCGTGGAGTATGAGGTCCCTGAAGCTGCACAGCTGGCCTGGAGCAGATGAACTCGGTGATGCTGGGGGCAGGAATATCAAGGTGGGCAGACCCAGCAACATAGGGCAGGCCCAGCCCATCATAGACCAGCTGGCTGAGGAGGCACGGGCCTTCAACCGCATCTACGTGCCTCTGTGCACCAGACCTCTCAGACGATGACATTAAGAGTGTGTTTGAGGCCTTTGGCAAGATCAAGTCTTGCACACTGGCCCGGACCCCACAACTGGCAAGCACAAGGCTATGGCTTCATTGAGTACGAGAAGGCCCAGTCGTCCAAGATGCTGTGTCCTCCATGAACCTCTTTGATCTCGGTGGCCAGTACTTGCGGTGGGCAAGGCCGTCACACCGCCCATGCCCCTACTCACACCGGCCACGCCTGGAGCTCCCACCTGCCGCTGCTGTGGCAGCTGCTGCAGCCACTGCCAAGATCACAGCTCAGGAAGCAGTGGCCGGAGCAGCAGTGTGGGTACCCTGGCACACCTGGACTGGTGTCCCCAGCACTGACCCTGGCCCAGCCCCTGGGGACTTTGCCCAGGCTGTCATGGCTGCCCAGGCACCTGGAGTCATCACAGGTGTGACCCCAGCCCGTCCTCCTATTCCGGTCACCATCCCCTCAGTGGGAGTGGTGAACCCATCCTGGCCAGCCCTCCGACGCTGGGTCTCCTGGAGCCCAAGAAGGAGAAGGAAGAAGAGGAGTTGTTTCCCGAGTCAGAGCGGCCAGAGATGCTGAGCGAGCAGGAGCACATGAGCATCTCGGGCAGCAGCGCCCGCCACATGGTGATGCAGAAGCTGCTCCGCAAACAGAGTCCACAGTGATGGTTCTGCGCAACATGGTGGACCCAAGGACATCGATGATGACCTGGAAGGGAGGTGACAGAGAGTGTGGCAAGTTCGGGGCCGTGAACCGCGTCATCATCTACCAAGAGAAACAAGGCGAGGAGGAAGATGCGGAAATCATCGTCAAGATCTTTGTGGAGTTTCCATAGCCTCCGAGACTCATAAGCCATCCAGGCCCTCAATGGGCGCTGGTTTGCTGGCCGCAAGGTGGTGGCTGAAGTGTACGACCAGGAGCGTTTGATAACAGTGACCTCTCTGCGTGACATTGGCCCCTCTCCTGGACTTGCACTTGTTCCTTGTTCCTCTGGGTTTATAGTGATACAGTGGTGTCCCCGGGCCAGGCGCACTGTGCCCAGCCCGGCCTATAGTGCGGATAAAGGTGCGGATGCTGCTG + =3HEG&?II/EHD8B>D6:IAIDD@F3IFIHCEC=HIIA%GJIF;C%9I=KGJJGHHCI,GFH;HDB2I7@GII=EHI8G*@G;BKKIIH2>A/IK3H@I=HC-:9IBDHK5HFC8G4J?DBJ?=JG;;KG?IJJDDB:K882HE;JIFJHEGJFCK7K@K=@DJJGFEK-JKC;KJ>7KJ.JEJJHB1A?C=J:KGJ@@7E.89KFKC>JF;GK>BKK.8:H4IH:AGJ@7KH<8EEKK-0H&:B=K@:=KAJK5GD'K7IK-;KKJ$AKAK4CKK3IJJK:EDAJEK7H@GIF?FJ;CKK07D@JDIJJJKIB>7K?JKFJKBIK.JK&DKFJ?G;5K=HDH137;K8@KK:G=KCKJEKKJKIK=FK743%FGKKKHEKJ5KAE1GK2AJI5FE,C@?G$DEK/I7GEEGK/I+IHK8A:-FJJ,=,4G/>7I-AJ>2I/CE(EJJKKBG=K@BF+KEHJJJIKHHKI0B>HJ7KJ@B;K?C.JK=D2D5<=CKBJGIJJFJ5I<3E>GHE@IK59AK3K=KJBKGJJBJ:JJKEJG@?)IGJJE?9KBKIBJ7?JJK1HBJBKHK/IKAEJEI@?K.IGJ.I3DJ3HKK9IG'GIH,H1H0K3HJ4HC@EB:K%9@BAHEJ2DE*4K97KHKKJK9KEKDKK2?GIAJJK3IK?KFJ4JJBJ.38K+5:E(KK=K8KGKJHJKFKEIIJ*KF=KKG)FJIJHIGAKCK/KIDDDK(KG:=(%1EJ;GK0DKKG<(4IJG?EI1JJKHGKIDFIIJK>>:EJKEK81DGGJJII@HKJK7K>EKAGJJ.G-J04?JJEHA?HD%1J5I@AF$FJ'6>,9C)GK=HB/JCA;?BKK,JBJFI?KKKK?DK;HG4D1/.KKKKAJDKK'E9K:DK4I@K6KCGK3K=KEHJEFKKKKKGK0;KAKIKKK5GK6DJI;I:HIKFKHFJKDA?KJ=KKIKKK&K7HEKK@KHIIGIIGEBKJDJ@J:K6?H>KK.JJ/K@JHJH8IK.K8JKIGKKFKK(HKJHKKIJKDI=@IKK-GAC(17KK*ECHJFIK;BKGICBKB<8HEH4'%*EJKGAK(KJ-C>IHHIJ,KG8CKGGK)HB;KJKIKKKHK<=K5?J%>>IHI&BJCKKKDKKKFKGIK-KFK>EK(=;CHJKK;KJ&7?;IJKG@DK-GKK?KJJKKB6KK1B8JK&JJKBJJKKJKK0FGKK/K'K&JEIJJE:JI6IEJK0K6FEKKIKFH6=KH8K @rCer/946/25_1711_CCS ATGGGGCCCTCCGCGCCCTCCCCTCTCCTTTCTCCCTTCAGAACCTTCCTGCCGCCGCGTTCGCACCTCGCTGCTCCAGCGTCTGGGGCGCGTTCCAACCTCCAGCCTGCGACCTGCAGAGAAAAAAATTACTTATTTTTCTTGCCCATACATACCTTGAGCGAGCAAAAAAAATTAATTTTAACCATGAGGGAAATCGTGCACATCCAGGCCGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTCGGGAGGTGATCAGTGATGAACATGGCATCGACCCACCGGCACCTACCACGGGGACAGCGACCTGCAGCTGGACCGCATCTCCGTGTACTACAATGAAGCCACAGGTGGCAAAATATGTTCCTCGTGCCATCCTGGTGGATCTAGACCTGGGACATGGACTCTGTTCGCTCAGGTCCTTTTTGGCCAGATCTTTATAGACCAGACAACTTTGTATTTGTCAGTCTGGGGCAGGTAACAACTGGGCCAAAGGCCACTACACAGAGGGGGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTACGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGTGGAGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAGTACCCTGATCGCATCATGAACACCTTCAGTGTGGTTCCTTCACCCAAAGTATCTGACACCGTGGTCGAGCCCTACAATGCCACCCTCTCGTCCATCAGTTGGTAGAGAACACTGATGAGACCATTGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGTACTCTGAAGCTGACCACACAACCTACGGGGACTGAACCACCTCGTCTCAGCCACCATGAGCGGGTGTCACACCTGCCTCCGCTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAAATTGGCAGTCAACATGGTCCCCTTCCCACGCCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCATATCGAGCTCTTACAGTGCCAGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCCGCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAAAACAGCAGCTACTTTGTGGAATGGATCCCCAACAACGTCAAGACAGCTGTCTGTGACATCCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATCGGCAACAGCACGGCCATCCAGGAAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGCGAGGCATGGACGAGATGGAGTTCACTGAGGCTGAGAGCAACATGAACGACCTCGTTCTGAGTATCGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTCGGTGAGGAGGCCGAAGAGGAGGCCTAAGCAGAGCCCCCATCACCTCAGGCTTCTCAGTTCCTTAGCCGTCTACTCAACTGCCCCTTTCCTCTCCCTCAGAATTTGTGTTTGCTGCCTCTATCTTGTTTTTTGTTTTTCTTCTCGGGGGGGGGGTCTAGAACAGTGCCTAGCACATAGTAGGCACTCAATAAATACTTGTTTGT + **$()*&%)')(-+***-)(+-))(,,,$)*),&(&#"(+-+-*-)+*-,*+-)%(',,-**-,)+-)+--*-,'(*-----)())(---,-*-).-.+,$**-,',,--),)++-,**-,&,,,,,++---,-'$)*&('%)(#*(&,,&*+*))$)(*$*,+-)%--,*(**+-,-'--,,.-.,-*-&,().-)+,*---,')).,*-()(),,(&),&$+*(-)-+--+,$(##()',)+,$#--(&-,---,(%)(#+*#%)*+))*,-,,'$*-+&-++)$+.-,+.(,%,+)'(&$()+*.--+)'((*))%%%-,-+(),#%%&(----*--,',,(+*+()-(*)%%+(,--)+'+%,)--,***)(&(*&*,(,+)*)-*#&)($'&'$&((+++)+(-%)+,++----)+-#)))'*.,.--,,-%+,&'),*--')&',-+(&----*,&$*----*+',++)-)-,(,,),'+&-,)-(-*(*+)&+(,(),())"%)(&&+*%*'*+-+.-)((*(()('+*+&++)*.,'('%((*+'%*+,*+-+-+,&,-+,+-*,,+,,,*.-,-&*+,(,+')*--,#)-)-*&--+-)%))*)'+*(()''&)&(--,*,'(+(,&&%(+(,*')+$),)*),$,*%)%&%+*+(+-*(,'(($,-%')(,.-.--,(+*)-(-(+),,+)*-(--+,-,,(*&&('+%',,----,(+,)--).,-,,$%*(*(#%+,*.)+--,*-)-(*,,(*,,++()*,())),,"#'(*$***-+)-,+,(,'+$')&$,',--,)---)),.,(,',**,$**)---*.,+(#)--*'&+&,,+*$,,(,&*++-)(),(,*--*.)*-),-,,,#*')((&'#$')--),(,)-)'((,)'%,*-&''')%%#$&)(((,('),-%,*)&+(*((,,*'*)&((--,..-'+$'')-)(-*%)$$*--*--,)*+*+%*))+)'#(+,,)+-,$$''(,,+*-(-,(,(),$))'&-)---*$,*-(*,-)--,()&+&*(,*,)+&+*))+-'+,*&++#+&,--),,)*',)'()%-,((+(-),+&$&)(+*,'()-%%'++)*+,).,(*-+)+-,.)---*-(*$**-',.+-*)-,.)).,)*+-+,,''),)()%))-,)('*-,%))&*,++,+--)----*#(&'%&)*.-),*+)*-)&.*'+,,(,(--*,*,'#,-*+,),,,)+&''**)(*--)-**(+(,*,&+.-,--,,(.)-,'(*),*())%('%'&()--+&*%)-$&)*,,',*$++,-+--*,,)***,++)-++,'+-.--,&')+*(-,-%)%,).--'))+.--)(-,'(%,,),-,*$,'+++-+,)("'++-&+(,&()---,-+)+-(&+,(,,(')(,,*,'-'*(%$+,,),,(()"),&)-),%*.(%)%++&)'++++.,+),*%())-(#)()),+-,+(,-(--*,+)+-&'-,.-*'$,--)&$)++,+((*%)*(+*,,)((----+*$+%+++*-'))#*--+(*',-,-++%-*#((,,%)))(*-,,&*++-,(-,--*(-200/,,/-1.)/1////$0-*--.0.)-(101111.21+1/11/21*0,/&0-1...(*11//&*+,+.0,/2.)0,-/..2/,1/.- @rCer/947/25_2185_CCS ATGGGGTCCAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTAACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + ;@-=B=:?C=A=?>=A275A@@A;=:?<>>?;=;CA<<@=C<=@A:BA@9@:AC=C>@@4AA856C>8;;CB==?B7?B?@C=4A??3;CAA>@4?=5=>8<@@65?=<:8B?>CACA1>?7@=@@;5@;A?B>7?>8>4AA>><5A3:B6CB;?>?=@C?@7A3=A?;@=<@6@AA3BAACB?=>@9>;8:;A96@AA5A@;<@A@BB90,3290=89>>8BA<=A@C;A>CABB?8==@A;B=@A?CA??>AB5,;7%7<:7?>:<=?5@B4AA*><4,.)9?;?>@6$;;>>:3=@;??=A.=;3:=$@?>C57A>3>A7>B;AA5=86??AA?ABB8?@AC>;A?9?=AA7@8<@=A?)<7:=64=@?;98:?.B>@CA>?@*;>>:17?94:;9;@+;?A7@A=@??2:68>8:.<3=>@>?A@=<<@@==?@8=>;AA;=?C:?8A>9=;>@6::<>B;=@A9B6>9=>64@@1>A1<&:9:;8@:+?/3=><6@?4-=56<=:@<=A8<@;A73>A@;<:<7<8<=<9;>@9-0::?@??A==B=>(<@:;A,@<2.@95>@?>8>;;=97=B6C<@>?:B9@<=@AAAA?@A(?@@=30@B@=?>9@>$=9:<5A>>?@?B<8<<=?>9A594<3780997=755247<+=:=?;8:>>5.1=:34A?CC?C>7<=>==?4?;?B;7@@74@?AA;>?<9>?B@3=;=CC9B6:.;<@:?8=B?<<@@=>A>>43=;,=>5==8;AAA=59CC>6A7:@?AB>@9687>;;3=B??AA>B@A@=@A39A5>:?4;::-<86BBA>:@4=;A=C;@A>03>.AA5:@??5@:?6:>5?AB;??2@A@@;7=A=;@7447;BAA5C:A=B@4?;0;4A8;=8>;34@;;??;ACA@?9>@A8?:A1;<3ABA<=:AA,>0A5AB?7<5>;7:7:@CB9?B=>>>>AB65&::;;8C?6AA>C<7@9;?=)696=7929+/*51/.;4>>AC@?;4AA??<=<<;@==;>0>@?@C@7==9=A<@;8>@=;7B>;,><=@=B@;=@???B@A8A=<6:7@3<>BBB:B?:=9BBA@3>8'=38?>@0:55@<2>(>;3@A=A>7@@C?79>?AA8=?:@7<:?B@CC?/=;A;AA<@6?=8@>:>>?<=C=B@8<98=8>4=:'5=7<>:;:=0/4<;<=9;25;:7<;==82:4>;74>48=>>==5:9888<;3:1><:3<=9;88(:===;74596:06;992<56=:8:67<==;/;::9><6*7<29>>><;785<;=<27;<>=;>3<=2:782<=87?;6;:<:<=;4>>6/97=;%;6;<::9<>+99>(=:;;<=9:=>;<86=097;=<>>7=:<>;4:<96;<=:?<<6.8:98?;9<<;>>>993==6>=<<977;:3<><6>>33<;?4::>=79880::,;;992.;<<4/:88(:+?=:;====?9?=>=1;835==>=)<==9>;9<;4%-97<+8:>>88;.25<>=;=><896;5:9:;2879;)=:7=2<>782886;0=44<<62<957<578==::;4,7;:><;;:==84<1;197938:;:<8:<7<6=<=579389<<7>>9><><98?>.<::.9=;;?:3><=973<<>=7=>7?>1;:::;=9-9=:>;::66;3=::8;65>====>249<:767=:5<5==?>8<18#6<;;;8:9>98?9;>885<;6<:::570447;=<>;6;>>7>>?9989>>:<7>><7;0&9;=<;>9<38<<2?>5?80<>;);9;:<6=/;;;%:9<2488 @rCer/949/1913_56_CCS ATGGGGAGTCATGTGACCGGCAATGGCGGCGCTGACGAGAGTCCTGGTCAGCTGAGTGGAATAGAAGGATTTCTGCTGCCATCATCTTCCATGGGCTTCCCAGCTCACACGACCTACAAGTAGGGAGCAGGGAAAAAAGAGTGAGCCTGCATGCCAATTCTAAGCTCTTCAGGATCAAATGTCGTTCGTCCTGTCCAGAATGGCAGCCTGTGGAGGCACCTGCAAGAACAAAGTGACTGTCTCCAAGCCTGTGTGGGACTTCCTGAGCAAAGAGACCCCAGCCCGGCTGGCCCGGCTTCGGAGGAGCATCGTGTGTCCATCCTCATAGATGGCGAGACTTCTGACATCTATGTTCTCCAGCTTTCCCACAGGGCCCTCCCCCGGCCCCTCCCAATGGGCTCTACCTAGCCCGGAAGGCTCTTAAGGGGCTGCTAAAAGAGGCAGAGAAAGAGCTGAAGAAAGCTCAGAGGCAGGGGGAGCTGATGGGCTGCCTGGCTCTGGGGGTGGAGGGGAGCACCCTGAGATGCACCGCGCAGGCCCACCCCCTCTCCGAGCAGCCCCACTTCTGCCCCCAGGGGCTCGGGGGCTCCCCCCTCCTCCTCCCCCCCTGCCCCCACCTCTTCCTCCTCGCCTTCGGGAGGAGGCAGAAGAGCAGGAGAGCACCTGCCCCATCTGTCTGGGGGAGATCCAGAATGCCAAGACATTGGAGAAGTGCCGGCATTCATTCTGCGAGGGCTGCATCACCCGGGCTCTGCAGGTGAAAAAGGCCTGCCCCATGTGCGGCCGCTTCTATGGGCAGCTGGTGGGCAACCAGCCCCAGAATGGCGGATGCTGGTCTCTAAGGACGCCACCCTCCTACTACCCAGCTATGAGAAGTATGGCACCATTGTCATCCAGTACGTCTTCCGCCCGGTGTCCAGGGGGCTGAACACCCAAACCCAGGAGTTCGGTATCCTGGCACCACACGGGTGGCCTACCTCCCGGACTGCCCTGAGGGCAACAAGGTGCTGACCCTGTTCCGCAAGGCGTTTGACCAGCGTCTCACCTTCACTATCGGCACGTCCATGACCACAGGGAGACCGAATGTCATCACCTGGAATGACATCCACCACAAGACCAGCTGCACAGGGGGACCCCAGCTGTTTGGGTACCCAGACCCTACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACAGATGACTGAAGGACATCGCCTTTGCCAAGGCCCCTGCTGTCCACCTCTACTAGGACCAGCAGAAGCCTCTTTCTCCTCTCTGCCCCCTGCCCCCACAACACACCTGTAGGGGACCTGTCTGACTGGGAAGGGCGTTCTGAGAGGGAGGGGCAATCCCTTCCCCATCCCCCACCGGCCAAGTGTTTCAATGCAGTGTGAGCCACTCCCTTCTGGCAGAGGCCGACCTCCAAGGCTCTGTTCTCCACTCCCGGTGTACATATACTCCCCGTTTCCCTGCCCCTCCAATGCCCTTGGCTTTTTCTGGTGTGCTGTGCTCCATGACCAAGCAGAGAAAGGACCTAGGGTGGGGAAGGGAGGGTCTCTTGATTCCCAACTGCCCCCACATACTGCTTCACCGCTGAACTTAGGGTGCTGGAGAGGAGGAATTGGGCTGATATGAGCTCCCCACCACCCCCCATGGAGCCGGCTGTGTGTGTTCATCAGATACAGTTCTCCCTTAACCTTGTCCTTTCTTTCCTGTGTCCCAGTCTCCGTCAGTCTGTCTTTCTCCGCTCTTCTCTGACCCCTGTGAGGAACCTCCTTACCCTGTTCTGGAATCGCTGCCAGACTGTAGCTTTTAATTTAATAAAAATAAAGTAAAATATGCAAC 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5598=,20867711)26*;8673793:;560;:9<9251749=59?89=7=88(.3680/$855=8=8::8/89:69>9690.+2<=1?36A=>:.8.9:.=>:9;.0;98>9(>=@?+3=;;8-37<:84)5::9<%48;B=:?@:=6.8>=A>>.A?=@:@C=>A?/@;C?A:=@?9>?=B<707B9B68>7188:?:>=;=A7@@A>>C:;B689>1?@0AA<1,6;:62.7956798:=67+8<14+16.87/(7<56/;914:2+.1-05969<;879>;9>=<7;59=2+99;/9:94682::0::&,1277'89878<:7(958;22/59'<.<=<1487873-<7:;<.4*>9<9>:6>5>6894(78;>7358+<9<2;9;9;<>1::4;97;*6:?1;49;457:+7:<768(8<8899896/73;>96<7<9765118$467/4;<-<>=9.46899;?>=9=7-92<=>,85682:2-594:>>+<9908:8:<<=1;>=99:7=<<;:,5/78:69&4;.;809;9;<89*15;<:9+5924;=7;1:=333(10<<666'4:/83'76/:42-8<9:4575777>477624&729<9,9:8<;:%481;;5256-.9<6;6122-8.5289:689640?55476;:37:9<7;8=6.:<9<988688):9'7;635:4;848;:99,8,=875754*566/7:;2<32:;790=;<>60738+5/479)79-;389>=515<3:48&451<4;233(4*66576:6;05=:;;6.9;02;:<9>5:57:=84496947:75;928347798;<9<=199<.8)69>;=6;::<+;>;8=599=9814>7+9>6<<,53(,5=7:?<<538<<=6:<9?:>>:<=;.2.:+=7=719>*147384:38178::25;28?>9879::89<31=22:6;6:=70/,*;>=16;=86+6;6;77:55853&47)<8/,)/84:477/81.18/;:8:6-83-358;7-0>4<;:885/7;:<;/<94574.+574371184354>7:84076=8::29;72+74:=>0:9:9;4:4=99>:8;7)4=9<>'.4<:7:58=92:8<=9875:=<:58:708(06&949/35550026)3;:<(07-=;=55-96;%60:=8<.6:5:/83<33=7261=;75>>9><;>88>>5407;;2693<>-;626;5?;;>?<5?45(=9<:>>761;9/+3189;2?6886165896429<<>-:76+;<.;==:>./7.50/9;8(;-<1662,-*66=4869,:5.55:4;7;;95;25-8343//;<3=<:7424::,4889,8.57,367-185+<6835(8:-5385<<<<:--0135<8;:?5>;<98>8<=6:5)004'1-7==<58:92:;(;20(3:+68:8<:58=7709==0684358:<7*037328=6?686884::8977:;2;8;;67>::6-316<-=85062658+94=985;=29197<;<;:+;7768<19734+.9599858'65;29=9453856572498&:>7<7=(608/,6031786492<5>>;7>39+8<94<4>=;<>?=8<;7:9&>9=>6?:=>;>603:69>7:97.958;1;6= @rCer/951/0_1486_CCS AGGTGAAGCAGCTGTCAGAGGCTCCTGTGGATTTGGCCTCGAAGCTGCAGGAACTTGAACAAGAATATGGGGAACCCTTTCTGGCTGCCATGGAAAAGCTGCTTTTTGAGTACTTGTGTCAGCTGGAGAAAGCACTGCCTACACCGCAGGCACAGCAGCTTCAGGATGTGCTGAGTTGGATGCAGCCTGGAGTCTCTATCACCTCTTCTCTTGCCTGGAGACAATATGGTGTGGACATGGGGTGGCCACTTCCAGAGTGCTCTGTTACTGACTCAGTGAACCTGGCTGAGCTCATGGAACAGAATCCTCCTCAGCAACAAAGACTAGCACTCCACAATCCTCTGCCAAAAGCCAAGCCTGGCCCATGTCTTCCTCAGGGATCATCTTCAAGGACGCACCCAGAACCTCTAGCTGGCCGCCACTTCAATCTGGCCCCTTTAGGCCGACGAAGAGTCCAGTCCCAATGGGCGTCCACTAGGGGAGGCCATAAGGAGCGCCCCACAGTCATGCTGTTTCCCTTTAGGAATCTGGGCTCACCAACCCAGGTCATATCTAAGCCTGAGAGCAAGGAAGAACATGCGATATACACAGCAGACCTAGCCGTGGGCACAAGAGCAGCCTCTACTGGGAAGTCTAAGAGTCCATGCCAGACCCTGGGGGGAAGGGCTCTGAAGGAGAACCCAGTTGACTTGCCTGCCACAGAGCAAAAGGAGTGAGTGGAACAGAGTTGCTTCTCTTTACTAGGAGCACATTCTTTGCCTGCCTTCCCTTCATCCTATCCTCTGCTTGCTCTCACCTCAGGAATTGCTTGGATTGCTACATGGACCCCCTGAGACTATCATTATTACCTCCTAGGGCCAGGAAGCCAGGTAGGTAGTCTGAGTCAGGATTGGATTAACAGCCTCCTCTCTTGGAGACTCTCAAGAGCCTGTGTTCATCTAGAAGTAGTAGTTTGATTCTGGTTTCCCTCCTACAGTGTGTCCTCCATCTCTGTGCAGCTCCATCATTACCATAGGGGACTTGGTTTTAGACTCTGATGAGGAAGAAAATGGCCAGGGGGAAGGAAAGGTGAGTAGGAAGAAGCAGAAAGCTGGGGAAGGCGGATGGGTAGAACAAGACTGAGAAATCTACATGCTTCAGAATTCGGAGGGCTCAGGGAATGGTTTCAGATGGTAGGATCTCCCTGCTCCCTTCTGTACAGGAATCTCTGGAAAACTATCAGAAGACAAAGTTTGACACCTTGATCCCACTTTCTGTGAATACCTACCCTCTTCTGGCCACGGTGCCATGCCTGTTCCTTCCTATGACTGTAGAGACAGCTCTAGACCCCTGTGATAGAACTAAAATGCCCTTTGTACTCTGCCTGTCTCCTGCCTCTTCAGCTCTGCAAGTAGTTTAGTAGGAATGGAGTGGAAGTCCAGGCTTGGATTGCCTGACTACACTGCTAAAAATATTTGTAATGCTTAATAATTAAACTTTGGATTTG + KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKK=KKKKK=KKKKKKKKKKKKKKKKKKHKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKJKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKK>KKKKKK.KKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKDKKKKKKKKKKK6KKKKGKKKKKKKKKKKKKAKKKKKKKKJKKKKKKKKK2KKEKKKKKKKKKKGKKKKKKKKHKGKKKCKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKJKKKKKEKKKGKKKKKJKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK'KKKKKKKKKKKKKKKKKKKKK:KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKFKKKK8KKKKKKCKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKIKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK4KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK;KKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKJKK2KKKKKKKKK>KKKKKKKKKKKKKKKKKJKKJKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKJKKKKKKKKFKKKKK+KKKKKKKK>0:1488,:712776&6498637&--14)+:#%87/6'*37)4062$0281,0(8/492%./*745=9=54'.52)<.5<9)67*1&8-*9'01795<88,6389;72<<:<<45>-'&$**0:.0::=52>>77()055+,:89+0,(.67)77'499=58:,8,7;48<;.;61$0#5366(2(10)8:82<18838*548*40702670%%%39')58//&;:%;8;;5)1:><)>4->>*548$..4*597:/?99888;'19;4,525-396))+*4<;0;==<)4+588%1:-/'263+)47;*2$7.$49=/:,..2697&3102*/--(3900%2()2'6,98;)4:2724*1536$)2'(/,)6;.+4.42886/<96=:3&4+2-%4(5163%-46;$#0/-9/8836':=<3.=8?8>110%:),1/%9567-$534:46*54*3663492&(9+.)).(.0(//522&3&1-.2(+5*6308/083$22..286,5+3&&*)+#-573.6799:3::.),0''&64'4+,/3&++/121&+(314&$')-$4,8/6::629/-'.37326,)1-,,8056(/%&7850*-';62'&+.2-,158/./06,.-)022,3/+%55-,46'8343*06%31802181302#,9-'/)8+*72&45',$)(0-'+4*8,/0&5:3/3::2236*47./$-7448(2(3%11/4%32,9:2&10&/34:23)373)(%((5220:.7+,6:5477*.-)2:14 @rCer/953/2217_55_CCS ATGGGGGGCTGCGGGCGGCGACGGCTGCACCATGGGCCGGCTACTGCGGGCCGCCCGGCTGCCGCCGCTGCTGCCGCTGCTGCTGCTGCTGGCTGGAGGAGCGTTCCTGGGTGCCTGTGCTGCTGGGTCTGATGAGCCTGGCCAGAGGGCCTCACCTCCACCTCCTGCTAGACCTCCTGCTGCCCACTGGCTTGGAGCCACTGGACTCAGAGGAGCCTAGTGAGACTATGGGCCTGGGAGCTGGGCTGGGAGCCCCTGGCTCAGGCTTCCCCAGCGAAGAGAGTGAAGAGTCTCGATTCTGCAGCCACCACAGTACTTCTGGGAAGAGGAGGAAGAGCTGAATGACTCAAGTCTGACCTGGGACCCACTGCAGATTATGTTTTTCCTGACTTAACTGAGAAGGCAGGTTCCATTGAAGACACCAGCCAGGCTCAAGAGCTGCCAAACCTCCCCTCTCCCTTGCCCAAGATGAATCTGGTTGAGCCTCCCTGGCATATGCCTCCGGAGAGGAGGAAGAAGAGGAAGAAGAGGAAGAGGAAGAGGAGGAGAGGGAGAAGGAAGAGGTAGAGAAACAAGAAGAGGAAGAAGAGGAGGAGCTGCTCCCTGTGAATGGATCCCAAGAAGAAGCCAAGCCTCAGGTCCGTGACTTTTCTCTCACCAGCAGCAGCCAGACCCCAGGGGTCACCAAAAGCAAGCATGAAGACTCTGGGACCAGGCCTCATCAGGTGTGGAGGTAGAGATCAGCATGGGGCCCAGCTTGCTGCTGCCTTCAGTCACCCCAACTACAGTGACTCTGGGGGACCAGGACTCCACCAGCCAGGAGGCGGAGGCCACAGTGCTGCCAGCTGCAGGGCTTGGGGTAGAGTTCGAGGCTCCTCAGGAAGCAAGCGAGGAAGTCACTGTGGGAGCAGCTGGTTTGTCTGGCAGCAGGAGGAGGTGCCGGCCTCGCCTTCATTCCCTCAAACCACAGCTCCCGGTGGGGCCGAGCACCCAGATGAAGATCCCCTTGGCTCTAGAACCTCAGCCTCTTTCCACTGGCCCCTGGAGACGTGAAACTGACACCTTCCTCTGCTACCTTGGGCAAGAAGATCTCAACCAGCAGCTCCTAGAAGGGCAGGCAGCTGAAGCTCAATCCAGAATACCCTGGGATTCTACGCAGGTGATCTGCAAGGACTGGAGCAATCTGGCTGGGAAAAACTACATCATTCTGAACATGACAGAGAACATAGACTGTGAGGTGTTCCGGCAGCACCGGGGGCCGCAGCTCCTGGCCCTGGTGGAAGAGGTGCTGCCCCGCCATGGCAGCGGCCACCACGGGGCCTGGCACATTTCTCTGAGCAAGCCCAGCGAGAAGGAGCAGCACCTTCTCATGACACTGGTGGGCGAGCAGGGGTGGTGCCCACTCAAGATGTCCTTTCCATGCTGGGTGACATCCGCAGGAGCCTGGAGGAGATTGGCATCCAGAACTATTCCACAACCAGCAGCTGCCAGGCACGGGCCAGCCAAGTGCGCAGCGACTACGGCACGCTCTTCGTGGTGCTGGTGGTCATTGGGGCCATCTGCATCATCATCATTGCGCTTGGCCTGCTCTACAACTGCTGGCAGCGCCGTCTGCCCAAGCTCAAGCACGTGTCGCACGGCGAGGAGCTGCGCTTCGTGGAGAACGGCTGCCACGACAACCCACGCTGGACGTGGCCAGCGACAGCCAGTCGGAGATGCAGGAGAAGCACCCCAGCCTGAACGGCGGCGGGGCCCTCAACGGCCCGGGAAGCTGGGGGGCGCTCATGGGGGCAAGCGGGACCCCGAGGACTCGGACGTGTTCGAGGAGGACACGCACCTGTGAGCGCAGCCGAGGCGCAGGCCGAGTGGGCCGCCAGGACGAAGCGAGGTGGACCCCGAAACGGACGGCCCGGAGCCCGCACCAGCCCCGCGCCTACCCGGGCCGCTCCCGCAGCCTGGCCCTCGGCGCGGGCTCCTCCCGCTTCCCCGACTTCACACGGTGGCCTCGGACCAACTCCCTCACTCCTGCCCGAAGGGCGGGCCTCAGAGCCCGCCTTGGCCCCGCTTTCCTGCCCTGAACCCCGGCCCCGCGGCGACGGGCGGCGCTCCTGCGCCCCAGGACTCCATTAAACCTGCCCGGAGACCACGCCGGGCTCAGCACG 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.078805+424389176+9:905+',6026,589:2:36.7326-988-.3157:292553:/0103267=93<4:>9:5:6;=;955;45-;176479609593:548;)3695980::7<85:;.65;;<;89799>>97$467==68//26;/79*7>85:%19<=;9893/?92:>29?;6;;8=96<39688;:;62=22,>?>9;?;8:93<<>9;962361<>>:=<=>;7/=>65;%4=?:7779<=,:<:829=;:;=.1:9/8565:.54<;=<772;9:5:84&8>5><>:27<2<7<:67&=9:7=92=4<6:;<;7>?334><7<:3=45/+=99887'=;;8.5==>57>?><199633+>84;36>8:7<=<9==9<8;:=8943)::23;75364;5798:>?>8/:>::::773:28<0:222<;&37368&:8668&;5.;758313372:066:8./-2.1>86:986:2)22-943/7907?9946>86>?=9:9:78:;/4&91:/91<==4663.<772,43515151<;>=>;;=<660331/3,762.4609/8673&,'71;4585;9.6>>>>786499;:+<387:98686+<19?=>74;;<:+7140354820,/00///3.%-+,+.142/3604(.878+0//7+177#479.5:3.5:22+,.1+653784799;635167:677977577-65986556491'/233&84*&12437223/1251934,052,243*:29059::::9/5:9::::053-5:37:1837:1133(..$18139333+9563234831462-2966818:3384544)362*37-47663981-365659/868/6671+%5%12-+0441870/)4/2.21(872/1621($043996033997.67.7-831+-99488634:7/3/15&5.-5484778-977253%9368:9640096655405.%*25(95604/6328987387:6701436*8$5979255/*05074678305345754/-3/818.,20*1237.9276$37.88,--0-558+80,6:4072523(2909547359794:09=08<3>:7.-*2650:2<94:4/$3:6<82>>=:/636=8880;91?;7:;?;8:65276<96543607765$84./+57<=60-8:+3;:;3=8012=9775<964=2=;9:67=94:56.:6=;7=7<;9:%8.>:6>07;38?<=>.0:80?6;836=8<;;89:184=>688=3;7<7=;:3570=;879.926=8996006(2392::;=;,8=<41:>;>>?9:9<:;=628?8=5:87:;=:>677?;6><,;<;=>9:;<&0868278/424944147>4:67?9=395552+606445:;;:56:::4=?6+?58:/:9>=88198>;;0667>:5=084>:<19554/9><8>?=:<59757<*7-<=?8?4;:97=846;99>9;?;>=;9:<;<45778:/6533<925(1=>;;==>-?<>499=773=6;;=;;8924992/)=8?5<8+30<==<0:<>=:32347888/)74+068)834<6<9&<4+(21/296/37755:99::859>>;9?68=792353,:<:3.;=<8=82><188##25=6<3289836>63359:>;8=:?;:79<8?579>24<;2*213:7:;;<(99(><=/8::;=-3='?8=;985:;:':;778178678'17&75;7*8;59-=9<>;3:=99385=488:6688::534995:<:,91:897<01-87/738:;55445;;:,158,7.3,<=442095;<6;4<74882==:64;712-8881/::88/;99??;;9;9?<790;80787018<36098756;=*:89/<<=%58=78--1/2=35?7:79;?48::>/0>>=/59:<:;48:;:19>99<)5;=.>:9;6:;;>?06;0=+939:9,87<=08972:7'2;<4>==2869<5*0++#)(2777082,1/62;$67;8=??2>::8:0<84:8;:1:+6:9;(?7387=7605?57<*64;=28738 @rCer/955/25_1626_CCS ATGGGGATTTACCAGAGGGCGCCAGGGCTGCAGTTGCATTTGTTTGCCGATCAGAACCCGAGGTGTGCTTGTGGCTACGGCTGCTAACTGGCTGCGCACAGGGAGCTGTCACCATGCCTCACTTGTACCCAGCCCTTTCTGCTGAGCAGAAGAAGGAATTGTCTGACATTGCCCTCCGGATTGTAGCCCCGGGCAAAGGCATTCTGGCTGCGGATGAGTCTGTAGGCAGCATGGCCAAGCGGCTGAGCCAAATTGGGGTGGAGAACACAGAGGAGAACCGCCGGCTGTACCGCCAGGTCCTGTTCAGTGCTGATGATCGTGTGAAAAAGTGCATTGGAGGTGTTATTTTCTTTCATGAGACCCTCTACCAGAAAGATGATAATGGTGTTCCTTCGTCCGAACCATCCAGGATAAGGGCATCGTCGTGGGCATCAAGGTTGACAAGGGTGTGGTGCCTCTAGCTGGACTGATGGAGAAACCACCACTCAAGGACTGGATGGGCTCTCAGAACGCTGTGCCCAGTATAAGAAGGATGGTGCTGACTTTGCCAAGTGGCGCTGTGTGCTGAAATCAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAATGCCAACGTGCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAACGTTGTCAGTATGTTACAGAGAAGGTCTTGGCTGCTGTGTACAAGGCCCTGAGTGACCATCATGTATACCTGGAGGGGACCCTGCTCAAGCCCAACATGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCCAGAGGAGATTGCCATGGCAACTGTCACTGCCCTGCGTCGCACTGTGCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCGAAGAGGAGGCATCACTCAACCTCAATGCCATCAACCGCTGCCCCTTCCCCGGCCCTGGGCGCTTTACCTTCTCCTATGGGCGTGCCCTGCAAGCCTCTGCACTCAATGCCTGGCGAGGGCAACGGGACAATGCTGCGGCTGCCACTGAGGAGTTCATCAAGCGGGCTGAGGTAAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAAGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGGTAGCTTCTCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGT + 1789??>:7?3*:+0347;=;79/188<5:87;=9:7;7>><.<3:41=:83162<8?:364?990:31;28389=>>38:>>505;=:(888;9=:;>6,=:7:<;:;33.688<09969=49:)&(,,,018::6=89=;,37:;96-69;<8:39<>639=:<982:7)816288;;5>3<12/<:9%8896<:*;:>9:8:7887+;>?9=>54;;9=44/35<7:)94=8?0=89492073728/><3;48==62<3898>>839=7;24(68=80=6725.61/34+-<<9<5>=>:9488:=9051:::;::;5<=$<1<:9-:789>5676:-<:<927=:3979;:&7879:9:>;<;??/98<3;0;2:?=;+9$53:9=<*<;7?;?>9,7:8=979:9?==16:<>86:8:;;618-9><9*:<;9=/6*5>:;$:86368<6;842<=68<56;15665$86;6.80/5=?:::9(8:+;3=:;:=<*>;5<;<:2;:8?5:99659;;;<,)(597+:==969<:7<75528-6<6&79;94:(85685/-)3,/59719;733<95<7>==99,>344=<6886878:5-,9:::=;>><>;>=7>>:=>>,<76<=43581=<=9>:?6=4:7;9==<,<6+1467;==>:37=96829162:2>49->=;<>=;7<679(236::<:8724:9;==99*<(5<>;<4>:8:&518+8=B@:::AA7><;9B8@>9<<4C=79:4;=>54=5>>54;1?8(;=3<970:=4/;,;:60046<<8:::1:=7:54:7146=:3?224>4$::>8988210/681/72758;=6852),75564,*:=1=8>6>4=9,4:?7>9;;9:48+8:<;<6:998:<.9;>==7=?;8;>=<1,2<9;988=:<1>/6548:?68781;=9/5-;<420&5/39;8;22%189695:9879;633><7:=>-9><:76;<3>78==9>><:9>5;;;<>8>=;6><<7;<36:138<)3<457<;><;6><>==>5>66-<<<>3.7217?==1<67953=;385=92=6:67>34;88888;;=8>>>9<:1689;;4;<67456.=<7.1;3,70,48<9;:844;:7=,.-08512:64;;77=>>:==:262548;59.214,:>:6:850;88-9:42832+599=92=;?=;8>889<748=7=)451=86=;>688:>>97767;>,<==>5::>5>*5::=?>:<>94<570:9(;25:9?9??:74*43;'964(7<2$)003-(*,8740)3.1466?::9-7-;<:9=987==;:=8::8>9-.30?99?>>BABBB>;@A?,A?=2?3<@>9@5C@96:):<;::.05-;@76>>>=A8:<995:+:9<(:7;:AC=&8005935-29/219:1<@=3@;98$855=8627;5A88<8;A:;55.77:592>=?,<=(:6>5;9484;25;68?5B:=AB=A?<<=5=:>?8@@:<:>=;=96979=?6457351.68;198=?:>98678*19=;+521=*8+6;7;;8481;=891;7-=;13'8:147489<>>9)<5408938:/:+99:,>>>9>=2=;2:9<5,;:<92<>9=>:68<8;=82<<955=;:7786<3;9;=>->>/<<8;7>*-&(.07::;5-;>=?9=6:::*==(;99:74=78+6:9>:8:;>,99:=;>>9?=6:73=5=;6=;=<8;=<9>>5>=<;3:><*;8:3<9;2)6>?>>?<;2>;:.<8==?8?>85=3?>?9:942:88592=7<:78*<=8)15579;)>(=844<69=<;42886:>8;>8;8469631,96=69:9=8->><7<98=>';==74369;?7>;<85(2/66;>7<1?7-<7955=<2=62;:)5>>69>8=?4?=31:<.6033::>9:?;59,<980===+<9889=65476<>:<*6+:<73>;2:37.8>>>98=987:<.9==4469+58;83=8>=::;=9::>>>7=:197<;8+67=;113::94:4=3;=19;89>:9?34?(;;8;3<>:<<8-707:<<==>998:44;;4>6983:2+:=5?==2=6?>>:;:&838-93;><45==:9<6=929=;0:;>3>67<9:8;3;2$;8:;99==/7/29=>81<>39:<>88=><<*;7=:;?:;*:3=>=23<<78;67262663,6726'76::=42:55<279?>2:9-9;84==<6+;3*2.1(51:67/661/443633895605547864(07:6:::6*6:86399565.5791:652$5*1-913.8510357:99879&78;;:99.780:&./77:82471186-56887:5(6846:05:6555.:487339;:5846:5856;:85575:29254436:,32:758-9/:7168;54*96(#38486)87382'05410.5+567789;66:866886515222907:/887:6473&%.+035:2+486;6.67734,:744:09.256979;9-9*018559,49:759:+9995830684:-985.::84+8849016334:047:9/659:2569498::99544/7::42)4*55519)68525.6:.(7%+477657588687307,/4191.35:435:;:40/99--57;2$416;;9&11;)*4&072:759-3:4,4/4497&875834)7222:193829.:93035:5279'4379;99;0874464:05&*,74:6;16695776;:::;:569:691&//1236578:5;1:99442-79:77963%545+2839331&39656/77799&22022:6;;91357659658::3&6-9:8-6692989:989;71990:91'664.3:912820324.:365::2533:2594:41:835.1;:9;5:37888*85999141/35*13&82+6-66;;:5-6824386592484,884/(0$-120;89609888/7,44:5;8398587:68(1.03.24:5637;:79.98.79:9-7489&76208?:;)866488067:2+7<8<:08:;;6-<55787579<;<9 @rCer/962/1854_57_CCS ATGGGCATCGCAGGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGGAGGCAGAGCGTCGACTATAAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGGCTAGACGCTGAAAACCCACCTTGGTTCCGGAATCCTGTCCTCAGCTTCTTATATAACTGCCTTAAAACTTAATCCCATTTGCCCACATTACCTAGTTAGAGCAGATGACCTCTCCTCCTAATGCCTGTGGAGTTGGCACGTCCTAGCGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACATTTCAAACTGTCACTTCTGTGTGAAGGTCACATTCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATTCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGCGTGCAGAGGAGGACTGTTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTGCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACACCGGATTAGACAGTCCAAGGAGTGGCTTACTGCATGTGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAAGTCCAACGTGGGGCAGCCAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACCCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGACAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGAGAGTCCAGGAAGAACTTACGCACTCAGAGGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGCGTGCACCTGTTCCAGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCTAACACCTGCTGACTCTCCTTTTGCTCTCCCTCCCTAACCTACTGACCCACCTTTGATTTTAGCGCCACGCCGTGATAGGCCTTCCAAAGAAGCCCCACGCTGGCATCACCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTATATCATGTCTATTAATATAATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + %+,-+((&)'*&),'-.,.,)-*(+'-**)$'-)-+((,&*&)-'))----,,)#')(,,++(---..,.---)-..,.----*&*$,.-+)*,--+)$*)*,&*))*#,+.,()(,'$$)*(*,&))),-(,-,(,--+,,,,--)-,-)%+$,+(+,'))-,&,&,,)-.,-.,('),*('&+(*-)',()*,),+''')+++%)((((',-,-)'+%+-&&-('(.*))+(-,.(+)&'++.--+)(+,+()'$(('-,+*-.+,---(',.++&+)((,.(+,-(')))#$&"$,+&)$)%,--&((-#*)%&&*)&$&&*)+%)*#(,-.--(""#')--+&'%)%$"-(+('*%**'(+**(&%#"#"#"%$'&&&'&#**%($$&&&',)-.,-*.-,---'--.'++,,,%&)%%""*'-,'(&,-+))*-%--*(,--.-.,(((,','$,)--*)+++'(,,)*()((#,-+,-,-*,(+,(,-**+'()--),'+)')&%*+--,(+),()'-*,+*-,++)$-.+)+),*,(+%%%%&''&%'&$#%#&&%,*$,.-,,,))..+,)---+,--)),+,*%),*--,-',--)&('(+,*',-(+--,,--)&(&(&,$('$&'&$*&''##('',-*&&#%*))(*&&%"&&(*'(--*),'*-(''(+,'+(#&*+-&"&&(%##&%'')%(-)(+-+''''',-**+"*'(,*'%%#'('#%&"',((*(%(&&(*(,.((+(',##'#'%%$#*+"%*+#(('&$%%'()(-+((#',+,-*-)+%(+,),0.*$+./*0(,+/.)1+,'&#%#($*)(*.-/&0)-,1+*%&,'--00-*0,)/,(($'$$(,&-)((%,+)+*(,'+,-+'&&)%%#*+,-()))---(*)*'$%&))(,,,-,&,,*-)&(+('$-,,''+,-,)',)(+'*%+,,),)'-,&+-+-$$"(*,,-)++-*-++,%(+-,(,.++'&),(())&&%,,%(-))-.+)+%'&*,)#&(((**$,,&*-)%,,),+,'+'#$(&++-,*-).-)+&+*,,+,(-,('($$,'(+(()*&*.**%%('&#&&'('((%+'%%,'&+&$)#+(($+,-.)&'''&)*-(&')'*'&,)('(()(+-,)$-.,-)+-*-,--.(+(+%',&%)$&'&((&''&((&'&)(,,-,,*,(+.+.+&,--+(((-.+(,)()+&&,),'#%+$,((,(',-(-,*&$*****(((,),***)&)--+&%$'(),-*,'&'%*$()-+(*&)(+'%)#"#,)''+,,),.+++'$&$#'((''%'&(*(,(()'$&',#)(-+*---,))&**,***,,%"$(&&&&'&)*'$)##$)&$#'%'%'(('%##%)(&))('('%(()'(&)())))(''%('$$#"#$$'(#(($()%%$%%##((#%&)))))))&%$(%(()&&'&#%&'""%&''))&'&$#$%#&&'#&%&%(&()(($()()))(&$())(%())))'$)()))&#%%&&$%&&&#)')()&()&%(&()(%()&(&$&($())()))(('##"%&%"'(&()(($$&%((&$$&')()&())))'%%$())&)%((('$())(&&%%$$'($$(%$$$))'())'&&%()))'&)')'%''%'$$%#%%(('((%(('%&)))((%(''%()'%('%()())&&(%()()'(&'))'(&%('&%(()(&'&)('))'(%%#(())'&'%(($&##(('())))')')'&%#(&)))(()(($$'&)(%(()%) @rCer/964/1617_58_CCS ATGGGGAGGCAGCGCGCCCGGCTTCCGCGCCATGGGGCGGCTGGTGGCTGTGGGCTTGCTGGGGATCGCGCTGGCGCTCCTGGGCGAGAGGCTCCTGGCACTCAGAAATCGACTTAAAGCCTCGAGAGAAGTAGAATCTGTAGACCTTCCAAACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAGTGGTCTGGCTTTCTTTAGTGCGGGTCTAAAATTCCCAGGACTCCACAGCTTTGCACCAGATAAGCCTGGAGGAATACTAATGATGGATCTAAAAGAAGAAAAACCGAGGGCACGGGAATTAAGAATCAGCCGTGGGTTTGATTTGGCCTCATTCAATCCACATGGCATCAGCACTTTCATAGACAACGATGACACAGTTATCTCTTTGTTGTAAACCACCCAGAATTCAAGAATACAGTGGAAATTTTTAAATTTGAAGAAGCAGAAAATTCTCTGTTGCATCTGAAAACAGTCAAACATGAGCTTCTTCCAAGTGTGAATGACATCACAGCTGTTGGACCGGCACATTTCTATGCCACAAATGACCACTACTTCTCTGATCCTTTCTTAAAGTATTTAGAAACATACTTGAACTTACACTGGGCAAATGTTGTTTACTACAGTCCAATGAAGTTAAGTGGTAGCAGAAGGATTTGATTCAGCAAATGGAATCAATATTTCACCTGATAATAAGTATATCTATGTTGCTGATGTATTGGCTCATGAAATTCATGTTTTGGAAAAACACCCTAATTATGAATTTAACTCAATTGAAGGTACTTGAGCTGGATACACTGGTGGATAATTTGTCTATTGATCCTTCCTCGGGGGACATTTGGGTAGGCTGTCATCCTAATGGCCAGAAGCTCTTCGTGTATGACCCGAACAATCCTCCCTCATCAGAGGTTCTCCGCATCCAGAACATTCTATCTGAGAAGCCTACGGTGACTACAGTTTATGCCAACAATGGTTCTGTTCTCCAAGGAAGTTCTGTAGCCTCAGTGTATGATGGGAAGTTGCTCATAGGCACTTTATACCACAGAGCCTTGTATTGTGAACTCTAAATTGTACTTTTGGCATGAAAGTGCAATAACTTAACAATTAATTTTCTATGAATTGCTAATTCTGAGGGAATTAGCAACATTGACCCAGAAATGTATGGCATGTGTAGTTAATTTTATTCCAATAAGGAACGGCCCTTTTAGTTCTTAGAGCACTTTTAACAAAAAAGAAAAATGAACAGGTTCTTTAAAATGCCAAGCAAGGGAGAGAAAAGAAAGCTGCTTTTGAATAAAGTGAATACATTTTGCACAAAATAAGCCTCACCTTTGCATTCTAACTGCCAGAACACGGATTCCACTGAAACAGAGTGAATTATATTTCCTTAAAATGTGAGTGACCTCAGTTCTGGCACTGTGACCACTATGGCTGTGTAGAACTACTGATAATAACGTATTCTGATGTTTTGTACTTACATCTTTGTTTACCATTAAAAAGTTGGAGTTATATTAAAGACTAACTAAAAATCC + ;BGGF.CFE3BH>EFC8AGC@@@BFH7DJ>HD?EFC>CABEEBAIG@?B?FH8DGD:HDA@EDC;:E>;DBFCBFACDAB8=>@:@G?DC@=?1EEFDDGC@AADC>D=E@;BA?<3AC?CE?@/AE5BCGFD26EA?AFC6EDBF@?,CC?:?5BC@E?>CD@E@:D>>D@CE@CAA?A5A@?77CA@?A<8?:>A@C6FDD@,DG>A=:4.055A@>:6=>CCA:;><>><96<>=A>)C;>AA7?=7=9=>37?@BAA@66>.<9?:?1A<6=;>5=C>C@7?0;4>+?F?ECBD>BC@@7F>9B@;>:7/?97A8;<=;==D?4>E?4;@BA?;:<3<#0@9A?@=7?<89366567BAE=BEC??64<09D2<>B?<2E@FE=BBCD'8;)6@3BC=CCA>>?1AB=?ECAD=B::D?CAB>:(<=:45353@89>D=2D;2@:B>F723;B?GCAD9@:C>FCBGFA?>8A94?6A=>ACD@A.:9=5::387:97/3163@BEE=FA>CE6>@:C7>>:,24@;':=A>BGA=B>>>>@>:?;A95>@;;A;?3<@C9AFC0=9;6;*B?A>=)<7'4':573?EBE3AF@?*177/BAGBBEBCDB5?>9E;AA;0;=BB47AE5;:<<72?=DCC?@6?4AA?AD=<==:;2;679-8/@F?>@@=52;5@94@EEE:?8@B9)%6-..$,/%$'8.8?@6B@8B@EBD>@CA<@A:EAED2B6?&CDB@BA&>@DD><9@3?>=7+1DB>4AECBCD@3>;@;83>69>8'68E>A?DDG@HECGACIHEFDG:>ECBFICHBD@AFD@H=I=;CEEIDF>E?FJEDH>@D5E?A0CF>BDFH?IJCDIGBF;IAIECBEF7H@AI,<@B=DH:BH79FAAFA:F?IHDJEDEIDCE6GHDFDBFF>HE:EBD>BEGHH>E>;8=5GEAEDEGC=CDC=I?DB:DIIFE@BE=;CCH@EF@JEFGHICBAIE@BBG+CDFCI??C:HHFAGA@A0EDCA=:F?FHJ?D=BEHIGFGF>GGHG?2?EFE>JIIEHI9GEIIBBIDHIH2EHDCHGBIGIFHFEDFC0CBGGIFIH:DFFFC3;:<3GGGCIFHFEGCFHGCDD?ECBBHGE67>@#DE>HG=>=?GE:BJH>B@EF=;071:;A-A@EAHGIE?EFF9C8H1;=FBED-CBCED@7=;;>>@CGI;JACDIIH3HIG?GHHFGF@DEBHI?EAH-HIIEAA>DGDB>FHBHGACAFAB5HFBFFAH>DFDFGEFDGB=;:>EHHDCEGD@.ACH?GGGJBJJCBCHEH;FFGGF?*CFD @rCer/965/22_1867_CCS ATGGGAGACGATCAGGGGCGGGCGGACATCTTGGGATCCGGAAGTGCCGGCCGCAGAGAAGGGCCTCGGACACCAGTCTGTTCCAGAGCATGGCCGCGGAGACTGATCTGCCGCCATGATTGGAGGCTTATTCATCTATAATCACAAGGGGGAGTGCTCATCTCTCGAGTCTACCGAGATGACATCGGAGAACGCAGTGGATGCCTTTCGGTCAATGTTATCCATGCCCGGCAGCAGGTGCGCAGCCCGTCACCAACATTGCTCGCACCAGCTTCTTCCACGTTAAGCGGTCCAACATTTGGCTGCAGCAGTCACCAAGCAGAATGTCAACGCTGCCATGGTCTTCGAATTCCTCTATAAGATGTGTGACGTGATGCTGCTACTTTGGCAAGATCAGCGAGGAAACATCAAGAACAATTTGTACTCATATATGAGCTGCTGATGAGATTCTAGACTTGGCTATCCACAGAATCCGAGACAGGCGCGCTGAAACCTTCATCACGCAGCAGGGCATCAAGAGTCAGCATCAGACAAAGAAGAGCAGTCACAGATCACCAGCCAGGTGACTGGCAGATTGGCTGGCGGCGAGAGGTATCAAGTATCGCCGGAATGAGCTCTTCCTGGATGCTGGAGAGTGTGAACCTGCTCATGTCCCACAAGGGCAGGTGCTGAGTGCCATGTGTCGGCCGGGTGGTGATGAAGAGCTACCTGAGTGGCATGCCTGAATGCAAGTTGGGATGAATGACAAGATTGTATTGAAAGCAGGGCAAAGCACAGCTGATGAACAAGCAAGAGTGGGAAGCAATCAATTGCCATTGATGACTGCACCTTCCACCAGTGTGTACGACTCAGCAAGTTTGACTCTGAACGCAGCATCAGCTTTATCCCACCAGATGGAGAGTTTGAGCTTATGAGGTATCGCACAACCAAGGACATCATCCTTCCTTCCGGTGATCCCGCTAGTGCGAGAAGTGGGACGCACCAACTGGAGGTCAAGGTGGTCATCAAGTCCAACTTAAACCTCACTCCTGGCTCAGAAGATTGAGGTGAGGATCCCAACCCCACTGAACACAAGTGGGTGCAGGTGATCTGCATGAAGGGAAGGCCAAGTACAAGCCAGCGAGATGCCATCGTGTGGAAGATCAAGCGCATGGCAGGCATGAAGGAATCGCAGATCAGCGCAGAGATTGAGCTTCTGCCTACCACGACAAAGAAGAATGGGCTCGACCCCCCATTTCCATAACTTTGAGGTGCCATTTGCGCCCTCTGCCTCAAGGTGCGCTACTTGAAGGTATTGAACCGAAGCTGAACTACAGCGACCATGATGTCATCAATGGGTGCGCTACATTGGCCGCAGCGGCATTATGAAACTCGCTGCTAGCTGCCACTAGGCAGCTAGCCCACCTCCCCACCACCCTCTTCAACAGGTCCAGTGCCGCTCCCTCTCCCACCACACATCAGTGTCTCCTCCCTCCTGCTTGCTGCCTTCCCTTGCACCAGCCCCTGAGTCTAGGTCTGGGCCAAGCACATTGCAAGTGGGACTGGTGGAGTAGCCCCTGGGCTCCCTGACAGGGAAGTTCTGAGGCTCCTGCTCTCCCTCCACCTGTCTGTCCTGGCCTAGTGCCAGCTCTGAGTTCTGTGACCAAAGCCAGGTGGGTTCCTTTCCTTCCACGCCTGTGGCCGCACCTCTGGAGTGGGAGGGTCGGTTGCACCCCTCACCTCAGAGCTCTCCAAAGGCCAGTAACGGATCTCCAGCCCTCAGTCCCTAGTCTGCTTTGGGATAGTGTGAGCTTCATTTGTACACGTGTGACTTCGTCCAGTTATAAACCCAATAAACTCGTAGAG + 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@rCer/966/25_2819_CCS ATGGGGGCGGCTCCGCGGCTTCTCCGCCGCGCCGCCAAGGGAGTTTCCAGGAAGTGGCCATATTGGATCCATTCAGCCGCAGCCGCTCGGCGAGCGCGTCCCGCAGCCGGCTGGTCCCCGTCGCGGCCCTGCGCTGTCCCAGCCCGCCGCCCGGTGCGGAGCTCGCCATGGCGGCCACCGACCTGGAGCGCTTCTCGAATGCAGAGCCAGAGCCCGGAGCCTCTCCCTGGGCGGCCATGTGGGTTTTGACAGCCTCCCCGACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGAGACTGGCATTGGCAAATCCACACTGATGAACACGCTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGCATGCGTGCGCCTGCGGCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCTGTGGGCTTTGGGATCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCTGAAGTCCCTGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATTATTCCCATCATCGCCAAGGCTGATACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCCACGGATGACGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGGCAGCACGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCTGGGGATGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGGAATTCCTGAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAACGCCGGGAACTGGAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCTGAGGAAGGACAAGGACAAGAAGAAATCAGATATAGGAGCACACCAACGGGCATGAGCCTCTCCAGCTCTAAGGTGATGATGACCAAGGCCAGTGTGGAGCCCTTGAACTGCAGCAGCTGGTGGCCCGCCATACAGTGCTGCAGCTGCCTGGTCAGGGATGCGACGTGGAGGAAGGATTCCTCTGAGGCAGCAGCTCCAACACATGGGGCCAGCTCAGGACCACCAGGGCATGGAACTGGAGACCATGGTTTTTTAATGTTAGAACAGAAAACCCCATACTTTTCATATATCAATGACCAGAAGCGCAAACAATTTGAATTTCCATCAGGGACATCAAATGTTGCCCAACCCTTTTCATTCCTATCCATGGCTCCATAAGGGGCTTGAGGCTTAATGCCCACTCTGTGGCCAAGCTGAGCTTCCACCCCAGAGACCAAAAAAAAAAAAAAAGAGTCTGCTTTGTGACATCATCGTTATGAGTGGAAAGTACCTAGATGACAATGTTTCCATTCTGAAAAATAGAAACATACTATTCAAGACCAAGGTAGCAGAAAAGTTACTTGTATCTGCTTATCATAAGAAACTCTGCAACTTGGCAACAGTGGCCAGTTTTCATAATGAAACAGCCCTTAGTAATTTAATCTTCATGCCTCATAACAAACCAAAACCCCATGAGATTTCCACATTGCATAATTTGCCTTACTAACAGAATCATATCCTTAAGGATGACCATCATTTCCCCAACTAAAACAAATACAAACTAATGTATGATATTTTTTTTAAGTGCCAGATCAATATGGTCTAAAGCCTCAATAAGGATTGTGTGTAGGTGAATAAAGACAGCTAAGTGAATGTGTGTAAAGTGTAGCAAAAGCAGACAGATATTTATGTACAGTATTCATAGAATGGAAAGTTAAATATTTTTGCAGTGTGTATTTTAAAAGAGAAACTCACCATAATAGTGCCGTCTAAAAATCTTTGTAAAGTTAATTTAATGTCCTTTAGAAGTGGGAGTCTGGTGGAACTGTGTTGGATTTAAGATACCTTTTCACTCTCCCGTACGTCGTGAGCCTTGTGGGTCACCTCACTGTGGTGCATGTGCAAGGGCGTGTGCACGCCTGTGCTTTGCCGTCCTATGTTGTAAACAGCTGTTCCAAGGCACAAATGAGTTTAGGGTAGACTCTGTAAAACGCCTCCTTACTCACTATAGTCAAGAAGTCCAGCGGCGTCCCAATATAGAGGTCCCAGTGCAGTCTGTCCAGAATAGCCAGCTCCATCCTTAGCAGCTCATTCGGGGAATAGTCAGAGCCATAGTGCTTTATGAAGTCTTTTACTTGTGGAATAAACTGTAAAAAGAAAATAAAGAGGCCAAGCCC 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@rCer/967/1842_61_CCS ATGGGGGGCCGTGTCCGGAGGAAGTACAAGACCCGGGTATTCCCTCAACGGATACTACCCCCATCCATTTCAAGGCTATGAGCACAGAAAGCTCAGATACCAGCAGCCTGGGCCAGGATCTTCCCCCAATAGTTTCCTGCTTAAGCAAATAGAGTTTCTCAAGGGGCAGATCCCAGAAGCGCCGGTGATTGGAAAGCAGACACCATCACTGCCACCTTCCCTCCCAGGACTCCAGCCAAGGTTTCCAGTACTACCTGCCTCTAGTACCAGAGGCAGGCAAGTGGATATCAGGGGTGTCCCCAGGTGCGTGCATCTCGGAAGTCAGGGGCTCCAGAGAGGGTTCCAGCATCCTTCACCACGTGGCAGGATTCCGCCACGGAGAGGTGTTGATTGCCTTTCCTCACAATTCCAGGAAACTGAGTATCAACCAAGATCAGGAACAAAGGATCTTAAAGTTCTTGGAAGAGCTTGGGGAAGGGAAGGCCACTACAGCACATGATCTGTCTTGGAAACTGGGGGCTCCAAAGAAAGAAATCAATCGAGTTTTATACTCCCTGGCAAAGAAGGGCAAGCTACAGAAAGAGGCAGGAACACCCCCTTTGTGGAAAATCGCGGTCTCCACTCAGGCTTGGAACCAGCACAGCAGAGTGGTAAGACCAGACGGTCATAGCCAAGGAGCCCCAAACTCAGACCCAAATTTGGAACCTGAAGACAGAAACTCCACATCTGTCTCAGAAGATCTTGAGCCTTTTATCTCAGTCTCAGCTCAGGCTTGGAACCAGCACAGCGGAGTGGTAAGACCAGACGGTCATAGCCAAGGAGCCCCAAACTCAGAGTCGAGTTTGGAACCTGAAGACAGAAACTCCACATCTGCCTTGGAAGATCCTCTTGAGTTTTTTGACATGGCTGAGATCAAGGAGAAAATCTGCGACTATCTCTTCAATGTGTCTGACTCCTCTGCCCTGAATTTGGCTAAAAATATTGGCCTCACCAAGGCCCGAGATATAAATGCCGTGCTAATTGACATGGAAAGGCAGGGGGATGTCTATAGACAAGGGACAACCCCTCCCATATGGCATTTGACAGACAAGAAGCGAGAGAGGATGCAAATCAAGAGAAATACGAACAGTGTTCCTGAAACCGCTCCAGCTGCAATCCCTGAGACCAAAAGAAACACAGAGTTCCTCACCTGTAATATACCCACATCAAATGCCTCAAATAACATAGTAACCACCGAAAAAGTGGAGAATGGGCAGGAACCTGTCATAAAGTTAGAAAACAGTCAGGAGGCAAGACCAGAACCAGTAAGACTGAAACCACCTGTTCATAACAATGGCCCCTCAAAAGCAGGGTATGTTGACTTTGAAAATGGCCAGTGGGCCACAGATGACATCCCAGATGACTTGAATAGTATCCGCGCAGCACCAGGTGAGTTTCGAGCCATCATGGAGATGCCCTCCTTCTACAGTCATGGCTTGCCACGGTGTTCACCCTACAAGAAACTGACAGAGTGCCAGCTGAAGAACCCCATCAGCGGGCTGTTAGAATATGCCCAGTTCGCTAGTCAAACCTGTGAGTTCAACATGATAGAGCAGAGTGGACCACCCCATGAACCTCGATTTAAATTCCAGGTTGTCATCAATGGCCGAGAGTTTCCCCCAGCTGAAGCTGGAAGCAAGAAAGTGGCCAAGCAGGATGCAGCTATGAAAGCCATGACAATTCTGCTAGAGGAAGCCAAAGCCAAGGACAGTGGAAAATCAGAAGAATCATCCCACTATTCC + JKKKKKK3KEKHKKKJKJKKJK?KKKKKJKKKKCKK&KJKGKKIKKKKKKEJKKKKIKKKK=KKKKKKKAKK?KEKCKKKKIJKKKKKK7KKKKKKKKHKKKKKKJJKKKK=KJJKJKKKKJKKKK8KKKKKKKHKKKKKKKKHKKKKHBKKKKKKFKKEIDKKKIJKKKKKKIKKKJKKKKKKKKKKKKKKKKDJKKHKKKKKGIJ5KKJKHKKJKJKKGKKKEKKKKKKKJKKKKKJKKKKJGJEHKKDKIKKKKKKHKGKBKKKKKHIKKJK?E3HI6DK5KKHJK>KJKIIHFKKEJKK9K:JH2KJKJKHJJKHEEHF3FGJKGEGGG1GK=KF:EJKKKGCKHIJJ5AJCFIDGKJGIAC?GKKJ4KHJHDJKIJEJKIKKHKIKKKKKIKKDKKKHKGJHDKDHKKIKIKKKKKK>K6IFJKKKJJIKJFJK@KHKHJKK=KJHKJKKJKJIFAKKJKKFIAJJ?KJKKHFKJIK?JKKFKJKCKK@KKKJKKKK;GJK=KBKJKKKKDI7KJKKIIJKJIKIKKGJKKHKKKKKJKKAKKKIKKKKKHKHJKKKKK=JKKKIGJKJKKKKDKKDKKK;HKK4KKK@I7>IKHKJIK@JJKKKKJKGKKKKKKKKGKIKHCJKFKKIKJKIKKHKKCKKKIK>KKKIJJKKJJJKK-KKJGKKKJJKKKKKGFIK8IHJKHKHKKKFKKK@GKKGIKKI2GGKKKHIJIHJAFJ@IKKHKIHEKKK=KKKJCKKJKKKKKKKK8KJKKKBDJKKKFIKKKHKKKKJIJKKKJKHKJIIDEKJKJKKK:JKJKKKKKIKKKKKHF?DKGKKIEKKKFKIHKJEGHGKK.KKAJKKJFKHKKIKKKKKKK?FKIJCHKKJIKJGIIKIKKEKKDJKKGK7K6KKGKIKJKKKKKKGKJJKKGJGGJKKKAKKJJH6KKDKKKKJJKIKKKJ6JEJK@JJKJKHJKKHBHJKGKKHFKKJJKK:KJJKKFCKKAKK@CKIKKKKKKKKIKJJFKJKKKKKKK/JKKKJKFHGKJKKJJKAKGKKJKGKIKK>GKFIDKKIKJKJKKKJK;GKKK2KKHHJKFHKKKKKKKKKFKKKDKJK=KHKHKHKKJKKKKJKKJHJHKKAJKJKKKKKKKKKJJKKJGKKIEKKHKAKK8HKJKKKKKKKK@KJKKK4JJHJKIKK=IKKKKKKKJKKKGKK @rCer/968/1621_57_CCS ATGGGACCCCATCAGACAAACTTAAGGTCATCCAGCAGACTTTCGAGGAGATCTCCCAGAGTGTCCTGGCATCACTCCAGGAAGACTTCTTGTGGTCCATGGATGACTTGTTTCCCGTTTTCTTGTATGTGGTGCTACGGGCCAGGATTAGGAATTTAGGCTCTGAGGTACACCTCATTGAGGATCTAATGGACCCCTATCTTCAGCATGGGGAACAGGGTATAATGTTCACCACCTTGAAGGCATGTTACTACCAGATTCAGCGTGAGAAGCTTAACTAGGCTGCATAACAGCTTGAAAACTGGATTATCTACTACAGAGTGTTATAACACCATCTGGAGTCTTCCTGTAGTGGCAAAAAAGAACAGTGTTGAAATTGGAAAGGACTTTGTGTTATTTAGGTTGTTAGAATGAGCCTTACTAATAATAAGAGCCCTGAGCCAAGATAAAAGGACTGTATAGTTTAAAGGGAGGATTGAAAAGGAGGTAAAAAATCAGATTAGACCAGTTCTTGGCCTATGATACCATTCATCTGCTATTTGAAAAAAGAAGAGGATATCCCTTCCTTCAGTAAAGGGTATGTCAGCTACGTGAAGTTGTAAGAAAAGCTTCCAGTAGAGCTTCTTATATTAAAGAAGTTGATGGATATTTTTGAATTTCTGGTTTGCCTGAATCCACCTGCAGTTACCCCGATCCCTTTGCAAGAACCAGATCGTACTTGAAACTATAGTGACCACACTCTGCCTTCCTGAGTCCCTTTCAGTCATGTGTGCATCATGTTTCTTTGCCAAGGGAGGGGAGAAAGGAGCTTTTAAACTGCAGTTGTAACTTTTTCTAAGCTTTTTCTTTATGGGAGAGGTTCTGTGCAAAACTACCACATCCTGTCCCCGAAATGTGGAATGCATCAAATAGGAGTCGTCTGCCTCTTGACTAAAAAGAACATAGGAATTTTGTTTTTGGTTTCTTTATCACGCTACAGAGAGTGAGTACACTGGGAATTCAGACACCAACTCTGAGCTGCTAGGAACCTCATTTGTCCATGCACAAACGCTGTATTCCGAGGCCTGTAAATGGCAGCCTGAGGAGGTTTTGCATGCAGGCTGTGTTTTCGAGCAGGACTAACAGTTGGAAAATAAGCAAAAAAACTGCATCGATCCCCAGCCTGGTGGTGTTCTTCCCTATACCTCACACTGAACTCAGGATGGGAAGAAAAAAGGAAACAAGCTTTGGCTTTTTCCATCTCAAAAGTATTGTGGCACCTCAACATTTCAGTGTTTTGCTTTTTTAAAAAATGCCCTATTGTAAGTTGTTGGTTTATACTGTATAAGTAACACTAGTAGCTGTTTTGAATAACATAGGTGCTCTTCCTCATCTCATCTCCTACACCGTGGTGAGCATACAGAGTGTCCTGATTTATGTTAAGTGACTGAGATGATAATTACTTTTGGAAAAGGATCATGGTTTTTGCTCTACTTTATAATCAAGACAAGTGTTTATTAAAATACTGTTTTGGAATGTTGGCTGTAATGTAACAGCAATTTTCGTAATAAAAGGCATTCATCTT + ABBD5<>3:/?D@B@@?@=53=4D:?:C@A=E7CC>78@EG;AA:??/A2=9<;BF<>:CCGB6?;.,18-?@?@@A19B;)8?3?AE<4693??BC==A5<6==CC=A6?6E@0>E:><5F@C@CCE:8@C@ABG=8C;(97?;@E?B;BBB;:A?8A@;9;=;)>98=>92/897AB@@'92>8<838@=:437;87;,3;B7A7:=5;-56@<<=A<46=/<:9B6A<:;6:=<9;560B9>7=A;<'?@678?=:;@?=89+:@?,?9@4?<5;B:A=?7<<:B@@757;;:<6:BB;791=4>B?A7B;<=>A?@:+.4+A?=6=?>BB=7A9=9B>97/@=?@90/8>7??A:69+B;??5879077:251CBA=<<:17=5<6;<>>=(B:>=<)?.9;=A?21>,:7?:>;248985@5;@B/;4;;6;1763@89;)6849<2287=:?C?3=C=@B=5>@78<;)C=B;>=0:51<6.9=1?A@9;7==5>79/19=9:<94?>>B=<4.4@25@:?=<:*>;3:=??)>A:5<0@>;7>=-<<7:;A6573<:*93:>=A.,.;;&>><<88A3:-<<9=1)0/6.>136:@?/7A>5=<12;8<376<>>=9855920;>:6:9=28:+=367+9>><00=9:2=+==:9:7*7=5>>=:;;;8;<=68;674*864)8;79<:(<=;;:=:81:87=5567:;4:8?>>2**4;2674486:97456&/9<.<976):,.8683%&6);:;9;>::5=94;:9<;>5:><>?;;82./-17,;<*?:97=.28=:<';9;835>81:85.0=?>88;016:=:<8.<>;59:==-;8=6>;:6153'71754:29>8=>>=:=7;/?::9968295;7156:=8>316;<=9558-:-9>=,<9>=5=:59=1:;8:,<<=<1;4/7==+>=?879<<0<99136<>,;9;:><8(5>>?68:<=6?98;<'9?>;;9<:778%<=6692<9=;79<$;:=58?;>?88781=?7;=5::4(:65===3:58;-;489<299??8:70.1487%2)>43>=;8=>>2<<=9;86&88;=;<<841&/8:>=4*93484&52;43>93:5>>::;=:(2)+9654(;==<7(;;;7360><6681==;8<>?>;=6.6733/-281;;<=7956=47+3866;?;;6;95;92<9/29+907>899444:838.>969=;=:;;;<868:<=::;1>08:>?;77:>=791:9;7/<8179797<;841<9;=>-?=9;;412=8=;;=598<9*6124797780::=;5:62008=6=9::<&0:588<+==:;5=><1?5;:;5712+3=;;?=<;>?9844420<9?36;>?70598(<56==83:;7<7 @rCer/969/25_1775_CCS ATGGGGACTCCGGAGGCTCCCGCAGCCCCGGCGTCCGCCCCGCTGCCCCCTCCCCCGGGGCCATGGGGGCGCCCCCGGGCTACCGGCCCTCGGCTTGGTGCATCTCCTCCACCAGCTGCCCCGCGCCGACTTCCAGCTCCGCCCGGTGCCCAGCGGTTTCGCGCCCCAAGAGCAGGAATACAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGGCCTGGGCTTGGGCCTGAGCCTCATTTTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCCGAGCCTCCCGGGTCCAAGACCCCTCGCCGGAGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCCGGCTGCATTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCCCAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCGCCATTGACCACCTGGTGTTGGAGACGGTGGAGAGGCTGGGTGAGGCAGTGAGGACAGAGCTGACCACCCTGGAGGAGGTGCTCGAGCCTCGCACAGAGCTGGTGGCTGCTGCCGAGGGGCTCGGCGGCAGGCAGAGGCGGTGGCCCAGCAGCTACAGGGGCTGGCCTTCTGGCAGGGAGTGCCCCTGAGCCCCCTGCAGGTGGCTGAAGATGTGTCCTTCGTGGAGGAATACAGGTGGCTGGCCTATGTCCTCTTGCTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCTCCTGGGCCTGGCGAAGCAGAGCAAGTGGCTGGTGATCGTGATGACGGTCATGAGTCTCCTGGTTCTTGTCCTGAGCTGGGGCTCCATGGGCCTGGAGGCAGCCACGGCTGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCTTATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTATTTCCTCTGCAACCAGGCCGTCTCCAACCCCTTCCAACAGAGGCTGACTCTGTCCCAGCGAGCTCTGGCCAACATCCACTCCCAGCTGCTGGGCCTGGAGAGAGAAGCTGTGCCTCAGTTCCCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAACTTTCACCAGTTGGTGGCACTGCTGCACTGCCGTGGCCTGCACAAGGACTACGGCGCAGCCCTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTGCTCTTCTCCCTGCTGTCCGCGGGAGCACTGGCCACCGCGCTCTGCAGCCTGCCCGCGCCTGGGCCCTCTTCCCACCCAGGAATCCAAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGAGCCCCTCCTCCCTGCCGGACTGGACCCTGGCTCCCCTCTTCGTTCCTTCCCTGGCTGCCGGAGGAGACCCCACTAACCCAGCCTGCCTGGGCTCTGACCACTAACACTCTTGGCCACGGACAGCCCGCACAGGACCGCCTCCCTGTCCTTGGCCTTGGGAGTAGCTGAGGGGGCAGACTAGGGAGTAGGGCTGGCAGGGGAGGGGCAGACAGCCTCACACCCTTCATCCCTGGCTGTCGGTCCCATCCTTGGAGGGACTGAGCTGGGGGCGGGGGACATGAGTCCCCCTGCTGCCCTGCACATCCCAGTGGCTCTGACCCCCTGATCTCAACTCGTGGCACTAACTTGGAAAAGGGTTGATTGAAAATAAAAGGGAAGACTATTTTAC + 9:(DE>=>CAJIFDEDE@*56<<$A=FGIHEA5IFEJIBGB@CC8.DFHB@8;FCDE?GAJIGG8EFA*JICHG?4G>?II=G:HIHIEB;JCEBBGEADH>G:IA;$>?AD-?EG?BC>ACFF9IH+JB2HCG;E=FD;GE@H?$=@EEJDIJDGEJFE=HCDD9JKKIJIJKJJJ:EHFEKHJHGFC@J7FDGJEHGGA=,@)9'DABEGC8HAKF8GG4GGC2CBCIH-EHJCGC'H@FGCKF>G@HHHHBIGGJC?HF?DF:B>+FEIEH>HEDHD6FA8@0IHCJJD9E;??7AG@KJIHJDH'C=46C9CFFEIIKGIJHEICJGHKJIH.@BGGG@7HHJIGIECIHHHJDIDGGFCHI6@FG4ICJJG3G>C?CFGCFJGJHIGKEHKH@G@D1D9AA;7?<$:CHIA=GHCDEDH2GE)C>C;<=>'DFF3IGECCC@I?;FIE4JF;D?1HF6E@;?5KGFAGHEH;@G96HKCFCDK?HC;?FAHG208@>EAH(D>7E:>H0IFGHDGGIBGEBHDFH?G?;B;JI9IJHGJJJIK?HKGKKFIHIKJJGKHGJDE2G=HH7@DAHIACBKIFK?E2EHGIBKJJJHI=HFIKJK5KFKHJKJJIHIKIKJDIKGKKCFCKGHI;HH5FFIC=@:HFJICK0?I>FB=IIKIHHFHAHADK5JFFEBIIJKHHIGDD=E>2@@GHEE,EB6FHAGJB@A=?FJIGIGBGG@G?I@FKJD=GKIHKK==J,IF/EJFBBG<7F@<<@E>A=F8B82@C4CFK5H@IHHADE6K;CDKHDJFGFAJFB(CA>JJIKJ=JFA4GFBFHCGGDIEHG1><:B@9BGKJHIHIHE,FGDAI>CEJHEK;KJJEKGKIJBIBAD=IJ9E=FGII8D48FGFBGGG$FHH?DIHHDGH-GHGI7IHA3KHJB*GJFE6JCJHI=AGC8?B0?@:IDDB=8D@EKGHJGE2E=&@BE>BJAI=EF7JIDI;HIG@C/IJGGB4EEJJAI@H>I:>&FG>BJJFGG$?B?>&>JD6@HKJGD)FAHKJC?-FFIHHJGFIFDAKEAEHEAHB:F93?9ADHAJFKJ=KKGD@KCI/FB>I@*CG;8HJI@I @rCer/972/25_2839_CCS ATGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAGTCTCCACCCCAAGTATCTCGTCACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACAAGGCAAATGCAAGAACATGAGCAGGATTCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAATAAGCTAAAGGCTGAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAACATCAGGCTGCTATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAACTGAATAGTTTTCTAGAGTCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAACCAGAGTACCCCCAAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAAAGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGTCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGAGTTAAACAAAAGACAGACGCAGAAGGACTTAGAACATGCCATGCTACTCCGACAGCATGAATCCATGCAAGAACTGGAGTTCCGCCACCTCAACACAATTCAGAAGATGCGCTGTGAGTTGATCAGATTGCAGCATCAAACTGAGCTCACTAACCAGCTGGAATATAATAAGCGAAGAGAACGAGAACTAAGACGAAAGCATGTCATGGAAGTTCGACAACAGCCTAAGAGTTTGAAGTCTAAAGAACTCCAAATAAAAAAGCAGTTTCAGGATACCTGCAAAATCCAAACCAGACAGTACAAAGCATTAAGAAATCACCTGCTGGAGACTACACCAAAGAGTGAGCACAAAGCTGTTCTGAAACGGCTCAAGGAGGAACAGACCCGGAAATTAGCTATCTTGGCTGAGCAATATGATCACAGCATTAACGAAATGCTCTCCACACAAGCCCTGCGTTTGGATGAAGCACAGGAAGCAGAATGCCAGGTTTTGAAGATGCAGCTGCAGCAGGAACTGGAGCTGCTGAATGCATATCAGAGCAAAATCAAGATGCAAGCTGAGGCACAACATGATCGAGAGCTTCGGGAGCTTGAAACAGAGGGTCTCCCTCCGGAGGGCACTCTTAGAACAAAAGATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGACTCTGAAGCATGAGATTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCAGGAGCTTCTGGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGGTGGACCCCAGCCATGGGGTCACCCCTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTCTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTTATACATAACTTAATAATTGAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCGTCACAGCAGCCTCCTCACTTGGGTACTACAGTGTGGAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGTTTACTAATTGGGATGTCATAGTACTTGGCTGCCGGGTTTGTTTGTTTTTTTAACTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATGTGTATGTGTGTGTATATATATATACATATATACACATATATTATGCATGTGGTGGAAATAATTGGCTAGATAGGGGATTTTTCTGAACACGGCAAAAATAAAAACACAGCAAAGTGGCTTCAGTTATCACTTTTGGGTGTCTGTATCGTAAGAAGTTTCTGAAAGATGTAAAGCCTTTTTATCCCATATCCCAAATTCTTATGAGCCACTCACAGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATCCCCTCACTAATATATTTATTTGTTATTAAATTGATCTGACTTCTCAGCCTCATTTGGACTAAAAAAAGGAAGCAGAAATCCATGAACACATTACTTCTCGGCCTTTTGGCTAAGATCAAGTATAGAAATCCATGAACACTAAACGACTGCATTGACTTTTTCAGAGAGTAGAAAACAACCTAGTTTTTTTTTTCCTGAATGCTTCATAGGCTTGTGAGTGATTTTGTCCATTCAGTTGTGCCTTCTTTGTATTACGATAAGATGGGGTACTTAAGGAGATCATAAGTTGTGTGGATTGCATTAACAAATCTGTGAGCCTTCAATGGGAAGACCAGAAGGGTGAGAGGGGCCCAGAAAGTTCATACGGTGGGTATGTCCCGCAGCAGAGTGAGGTGAAGCTTACATGTCCTGATGTTTTGTTGCTTATACTGTGATATCTCATCCTAGCTAAGCTCTATAACACCCAAGACCCAAACAGTACTTTTATTTTGTTTG + C=*A/?;/@C:>CEDDA=E:EFE;F;??9@,@C?E:DACC3?EF@E@EFCD3C8A>3FED@GFD9?@AEGD@=BEBEDFC?C:DCGEA?6D<>?;BAAFD;AB8:?=8?2CBCAA@A=B>5>7GFF=F9A9CECEFA<;>;:@:B?<5C?=FEG4>BBF4@BCFC;?D@C6E=BCFFGE;CB+C?>AD?@A?48@@8D=*ACDFEF@AFB@>ED>?:C;B9DDDDCG?<(?BABA;CC@=;@E?E>?=BB=GGGEC:CGFCF>BGE;DFBEE?;A?EGBIHC=FJE7HFADGII>AIDIA$DA30>8?ACD%==A5HHHJHIG9F7DAC'FBE@#AB:F?ICF6B0IBH/%BGED9?&>G=H;A:HHIEHF=GGEH6I@GG=0GD5BD:CIGFCFGJCID@ECFF?D>DGIJIFGEGEECICGIGEC@HC/B:HCAG?-DHI=E>EII@6EEFDEDD>CFGIAE9I-EEC=?=?;JEHHIGIFIHH?>EG>DGFGH>GC:DEIG<@@GFIGBB@DEGFJIEGJ>EBCEIGJ@DHHIIHCJHGEGD>IHIFHID=GIAA(BC>@GFG6CEHI1@@HFB?IFIDJH>;EBIHI?EFEH7EGHDFFCDF=CHGFIIGEIIHHCDFEDIEF8DGFC?J?JHCCGGG97EHIFE5I=CB<17:E>E5HCHIDHE;CDHC.GCDIEDDCHIG2C??GHC?GGJIFHBD=GGAGEDFH4B=HDDHHIHHFGFDI=IEEIIII7DDDCDEFFCIIIICB?:DGH*FFIIEGF>=7=CB=EEH6FA5F=DFA?BBBCIHAH@C3CC7A:*AB>DC+>AB@DDCGD:;:.A@ABCA7.>=@?9@8E2GA3@F?BEDAF@B;BCE.96?9)BB:@AABFD=?;?ECE:><<,;BE=54@C5B?BAAC?A?>;=ADF3GGGFCC:>:;#6>C?@>1B<7DC@D6?FFCFE9:9>,8@=/<<@>B89BEBB<97AACDA7(AA>;C?>?2DDE<@=8-7B?AB;>?@9CC:>>AA6B:E?/8C?7ACGDA=@@5C92FCD=DC@FFGFCAA5EGEEEGD6?D7DEA7D:F6B@@5B%>??1===@BAD0D>@<:EG@EFF:EB=?EB@8/=A=ECAFFGEF7E9BE1EBCC?8@A<>==BDCB7@DA;E;;@4=A;:8?*CA?C=CC@EB2DA@A8@A@A>B@==??:>CC?0D@)=9D?9D.;ACA>E;9AE-D:B@CB;>1;?DDD7C9BF>=6AAA;BA<5@6;B8?6<2;CCA<=8B99B@CCF?>BFDC=:B?*?A:CF?9;:>16=A7;2<=8175:B@=?F?E-EDA=D@8D:@ACEAG/CA@BA=@E:?@;C?FA=EBCCD>GEF8'AEEACDA;ABGGBGF%;AB64%8>=779:>C>8@BB>:C;@A48@=@>5=?=/@=B;BBDBABADBD:;D?.><8@BAGG0C@%BA>:?DD-B@:AB6G?>;@A=2+5;57C:B4A?6;5-ACC?@<7A?8@?=9CCD51278(?AA=F@,FDB@76C<9=9:.//=95*;>32>>:A8CFA=D@A;@9FA?>>=CF@EB;GG@FE<;&BCCDCAC7EB@;EB>ACF@?<;4C@C>D?ABEG?B0FDD@E2C@;4FA8C8B9>B/5>BCB?BCFCE>E9>@5BA==DEDEC7=>=@/8>A6%;3A>64'9=:946>@C;?AD>C#DCC>BBG79A?FDBBFBDAEEGF;DADEA,A@GF>@9EBFC2ACC>;@8FBB7?94<;<@=5>A9;8=DDAF=A@B;C@D6DCDFGBE<@2;@B8<>@9EEAFEC;AB??D=CA=>5>C;CA;A,??A;.;CDA:;=;@59836:=:EBG@>A:7:@EC95>388919>>>?626:46<6:9872>98:*<26-:;9976>::>8*:?==:9,84=81:29>9978&9:?3<;<<='1<=*==)7/:193,2$+;<846=<:9:65=?27<&57,:53<78>3=4<7?89+77992:=;$63$%()6<21=882<;09=<=817;:49:853+::=:59?9=>/6?5<+;98618&019?7667?9>>*7='8=0>54/22:>:;4:12?<6=8>66+=>71,>+1*?7:9089/)*663:77;:79?:654/5.2<7>1205&.9=&832=,535$.:+=4;847$09<1<49<9890'<0><:;89>:47$-5*2<9-5#75>7703++093,4;9((9;:;3947688:>808>=5:89<-29);9>1;==;>63<;8;>.6/';191=5<6*>/<670?>;<;:<>53<>3;=;9;;>/=60.67=23;<7;6;=9<11718:9/>69;>?;08;8+59+76:>>.9>58;<:<<6>=7736:99<;;;(9>6>9;;54<=)6;=6846>:7259:7.3<%?593:7?<8<9;9:68;:42:*7<>/=09;8>/+;;)6:/=<36889'3330639>9<>-<:7>9=+7*5*2=1>?698*5<8=49<(4:7<&2(;;:$0<=('88&849+9$1+#307?8898&1876-2/:584-:571673,3,<<;96'?4;>;>:/>;2<;:;/7<,3,7(,/;)5.36);1'*8)2$54=>::(>05;95,9(6;/1,502+/11.:>;=>9248;:?>;<&+541%.0-&392#/9:&.3468:>6;'<1>>=<==3<;9==='8>-<:<*>=78<577(9;)97%54:%/?6-:/876-#(<<%9768,64=15:4>1449>;:;>>?371<9/::=>-77;,::9==/=:68:((8;91<*6=;;>8>3=:+80/:%'./78:<&9>7;<3180-3>729)5;:2925(0;=9$;58:57.5<1<7>?836:<5<%*;79;<,9.43158*,=7/:659+<:;5>:8*:>;>78>=.9.5=:<:?<9,8=<+9:=?819?4>94==0=38;6(7<;4>==977'9;2<:==65%/12620784289+4.6)78488;37<52;786458=:88+2$<.933663===745309?6915:><+5>;<.=<93>;9+68446>76568=<<*;:6864//6)58;26:;?77:'1/.*8:<=132657>72/6)448=987=<3.8;96;20=1:67-%-:?>:56;&27$64,=;9/#(1=84962=;==+=;=>9<:7=?6:85>>2$409(5789:7>;=91$3(%2-&0+:5;;*+55:/13:5%36+=?9;<9=2>3:762-914;??09==:(/2139-?<>>>8:>?6-156)*;/76485653,7<>308:::<69::?=?7:<;<-;%4:$7=4>=.3%;97=6==:7*45;7:;(;37(9/9=30362<0-6=-42/?=98=>.3?54/;:*=<=;23>:77:=:=>345.:*:459:01;9?99?92,15:854<9%+:76+2=9:=:>2>;;;;.;:<<=,>><;?8?8<9:9):);0:8;238<<6>2:=>*),1<&76:6=5<=49=93691=9==98;12$30+1);4922=9850>39=;3=7;;+(5/::6*19$78<825;;;+163>2/0?-17=>9654=579>:8-977$49;>5656&033/:6>98=3;8:48:4871>47:&34*3*97:142184602)9<=)1<*==>/=??=>;>7=.<(17=*<7)2#;<=;5=7<>;:/*96-*9?;:(81:644<89;:=.8:<;17.61;2>:;8=2:<:3:6,2-3*7*8;.+549/:11892:8<0<:+:2899+6=22;2"==7977$67:$3<9<'5;-828,?9>>78/>(897>1;:<#2;:8,::<*;>/:84::;;035'#$'0%596125=93819,79256:72344-72:>9>>?:48<.82=664383-6$+6=&<':=0:/90:4>=1*2.8&$542%9809<=,17<08:94=;8+69;?<=783?92:98;4*8,8385;1951;;-<8<868<=6/7>6>;289>2=:>?:877;=;;<613);:=,9:17981;0:8:8;68;3==<9>=8;;1=66*>4;64=>353/3)9'9;8;;=.=5<;6:4;<=:44>:/>79?:8>9>;::;3-.*3?:<4;*6179<;3(98*/<6:8/8;?9):&756*5-$::;,;22,3%-:>?.)<4:?=9-($4;5'/*+;.=7=5<'0#8.74)91#557'.&8,$/-09'5=4379$)>:<)8.;%6:4=52=08.:)=;>65;3.26690'+48,5-*3%4,60-$0'8-&+487'7/66'+%%0+5&0(&/'5)'&25+.1&$8+537,447.8+8::-,4:-4(8;9:483.57,32(0%565&4707%.-53(::6118576+0+4-:/9:;746-2)344,6/:6945842396/.,2'&$.5/:48.:90.499195:86348.-8)5,'0/.77254&8,8:3571.4(0.49,05.64+06+;9;9;;78:84:-5+:;91682.6462752949:/:94.0697287/499)+100/60(96,887:87375'84/9;462375.582658&,2:8254:53+96,25,$3$.,65&9.$9%28/8748:43243059/:75;867797,-3771'4.,4*5655*5350/-15041),44$-*$./$063'51350%)5%*1'(51)5)2 @rCer/976/30_1693_CCS TTAAGTGATTCTGATAACAATTCATTGGAGACTGGTGAAATTTCTAAAAAGCCAGAGCTGGAAATAACCGAAAGGTCTTACGGAAGTGTGCTGCTGTAGCTGCCAATAGATAAAGCTAATGAGTGATGTAGAAGAGAATTCTAGCTCTGAAAGTGTCTGTTCTGGTCGGAAGCTGCCTCACCGCAATGCTTCTGCTGTAGCTAGAAAAAAGCTATTTACATAATTCTGAAGATGAACAGAGCTTAAAGTCTGAAATTGAGAAGAGAGAGCTAAAAGATGACAATCAACCATTACAGTGTTCAATTCTCACACTGTCCCAGAGTAATGTTGATGAATCTTGAAAACAGAGATTTCAGAGTCAGAAAAGTGATTTGCGGGTAGCCCGGAAAAATTGGCATGCTAATGGTTACAAGTCCCATACTCCAGCACCTTCAAAAACGAAATTTCTTAAAATAGAGTCTTCTGAGGAAGACTCTAAAAGTCATGATCAGATCATGCATGTAACAGAACTGCTGGCCCATCAACGTCTGTGCAGAAACTTAAGGCAGAGAGCATCTCAGAGGAAGCAGATTCTGAACCAGGAAGATCTGGTGGTAGGAAATACAATACATTTCACAAAACTGCGAGTTTCTTTAAAAAAGCAAAGATTTTGAGTGATTCGAAATCTTGAATCTGAGGAGCAAGATAGAGAAGATGGGAAATGTCATAAAATGGAAATGAACCAATTTCAGGAAATCTGAACTGTGATCCTATTGCTGTGTCCAGCGTTTCAGATCATGGAAACTGAAACTGGATTTAGATTCAGATGATGACAAAAAAGAAAAACCAAACAGTTTTATGAAGATTCTACATCACAGACAGTGGACAAAGCAGAAACTTTCCAGGAAAAGGTCTGTTCCAGTGACTCAGACAGTAGTTTACAGGTAGCTAAGAAGTCATCAAAAGCCAGAACAGGTCTCCTAAGGATTACTCGAAGATGTGCAGCTACGGCTGCAGTAGATCAAGCTCATGAGTGATGTAAAGATGTCAGTTTAGAAAATGTGCACACTAGAAGCAAAAATGGAAGAAAAAACCTGTCATCTTGCTTGTACTACAGCTAAGAAGAAACTGAGTGATGTGAAGAAGTGTACATTGTGAAGTGCCAAACAGTATGTGAAGCAGCCACCTGATCCTGACTCGAACTTAGTACAAAAGTGCTTAGTCAGGCTCTAATGAGACTCAGACCTGAAGATACGTTGAATTCAGAACAGAAGCACAGCATACAATATTCACAAAATAGATGCACTTCTAAAAGAAAAAGTTCCTCTGTAGCATCTCAGGAGAATTCAAAAAGTCATATTTCCAGGGAGTGAGCTGATAGGCATTTTCTTCAGAGTCAGCTTTGCACAAAGCTACTGCAGAGAATAATTTGAAGTGGAACTGATTATGGGCTGCGCAGGTGATGCAGAACTCAGGACTATGGAAAGGCTCCTTTCAGTAAGACAAAGTGAATTCATGATTCACAGGAGCAGCAGAGAAGGAAGTAAAAAGGAAAAGATCGCATCCTGAATTGGAAAATGTGAAACTCTCTGAAAACAACTGGAATTCAAAGTGTAGACCTGATACTAGTTCCAAATACATAGATTTGGATCTTAACTGAATCAGATATTGACTACGATAATAC + '.&*)(,112-0,).*.,*0/.+/,(00001-,,+/'+)+%+/0.#)(*+-1.-/11,',1-0/.*2&*/-21,/*%'-/.1.//.01-/)*-//*/*0,.0%+*)-')*/.1.10110+-..011,1/++*-/1-$)$,+0+111/'0)0-+/1'++,,./+,.,1..021111.2./&-1,*/0$.+/01110,'.1--1/0$//0,-(/*-%,,*,&*'&%'&)/,..10'*0/+(*,0+1'*-1110/'/0,10)*(0$0-#$&(*//221,**/11121.)1*..*0+%"+'*&*.*%$/'+..10(+/+%))+,**+)-,.(0-'.,+-+')+(&*/.+/0.,0%0//$(001,(0&(',,+000.1&)$),,,/$,*&((),,,*.%-,)*,-.,.--,,11.0/01'%./)+1.,-,123**'')%()(,(../,)**,--$&$&(+).-,2,511(.)02*340,/.*-1/,**,-+(&/+'-,01...110,.2-.--.0-/1&%*$(/++/+1/01-.-,).//+/-.12*/+0010.-.1*(,',,+.+'.+.%*11.%+/.....2110-0++.*,*-'&,*'*/&,--,1)0.1./++11-,)01,.&'//(''./(#($$,+./*(,-0-&)&/01+,+(+(%-&%,.$%%+/0',-#',-/.0.-1201'(+00*2,+%*/&,---(+-0.)--00%,.02+/('&*'.)01+*&+-21($&.&+)'*/111.-11*-,,./(-.$/*&*)+&%/1/1,*(0+($)(%,.$/0**%/,)--001+*+-.101-0*-/)0001/0*02-2'+),.)1*%.&**'*$0(,%)).0-,(-*'$%$&(1,%/0-*34143/+543'12(1,)/,4/0*322).+3/3+.,-.-,01%'115,%$,3++014215.*3%(+.1,*3//2+6640.0/($4,/362(2*20*((/*'4321/4.43,.#+/,.)*+./*1*2.$)(%&)+02*405,,)22+.022104(#+*-,+)3,),-040$033-.('*3033/*/12,.(422500.$-#&05666)//1/*,/,-314)0.,--,3250++/2506)153)(0./001$-10&$$23.20/2(1,/100/-14.+.$%!)*,,'$%$)&-.-%$(12'0,-.*05-((,((/)/,.4/0.-1(/12,.//-4)00-1./(*4'&0/$#+**20)$+((+'#.'0+14(350*0.4/0306524$,-01,-**-1'%*250/4.+0(2/.00.+*22+$*2*,2466/'10.,**/)-10*0.*+00%'$),/0.%&,'.(%)/..,.--.+#..&*/%..'%'-*(%/./+)%%"$%-/0&*20,-.,+1-/.+.(#%(+$0/++)*.1.--&&&%*&,,$00*.2,-%*+0-/*%(2,,$&*%*....0%+(&(,+*+,#%$(&++0'&%&*&,&(,+.*)',(-,/..,)*,,,#)*.,0$+)/0--'(%-&'++&+(+-$*++,**-0).,1,*&-000+/%/0011,0(,,-.21-&/&-02,22-'**'(1-*)''.10#*'*+/2--'.*0+.0-100&&+)&-#%*,,).,)0-01&-).)%"$''&+'#*%$+*-+(#(,*&(+-&++(&(+%*'*##"%))++-('& @rCer/978/0_4227_CCS TCTATAATTTCGAAACGATGTTCCATGTGGTGAATGTAAGCATAACCTCGGAGTTTGACTACAGTCATAGTGCCCCCTTTTCCCCTGCGAATAGGACGGTGGAGTGCGAAGGCGTCCAAGTTCTTGAGAGAAAGCCTGAGATAGCACACGGTATTAAATAACAATCTTGGCTATCCAGATCCAGATGGCCCACTAAGCAATAATCAGTAATGACTTCGGGCTCTGCAGCGACTGGAAGACCCTTTCGGTGATTCTCGGAGATTGACACTGCTCGTCACACACACAATACTCATCTAGCTATCACCACCACACTCAAATAATTCTGGGCACTTTGCCAACCTGCCGTTGTGTTCTCCTCTAGAGCAATTCAGCTTTTACACTGACCAACACGTTCTTCTGGCTGAGGAAGAATTGTACGCCCTCCTGCTAGTAGGCCCCGTACCATAAGCCACTTAAAGGCTTGCTAGTGGAGCTAAAAAGACATATCATCCCACTTGTCAAACCCACCAAAGTTTGACATCATAATAATTGTACAATATTTACTAAACATAAAACTTCAAGGAACCCTCTGAACCCCAATGATGTCCAAACAGAATAGTTAAAGCAGCGATCTAAAAAGGAAACTCAGGTAGTGCACATCTCCACAGAGATATGTGTTGAAAACTCGTGCCTTGGGAGATGGAAAAATACTGCACAATTGTAACGTGGCATGGTCTGGTGAGACGCCTTACAACTTCACTACGAGGCAGTGCGACGTATTTGTGTGTCTCTGACTATGTAGTATAAGAACCGTCTACATCTCACAGCTTCTTGCTTCTAGAAGGACGGCACAGTGACAGATATGTAAAGAGTGAGTTGCATTGGGATATAAAAATTAGCTCGCTTCCCAGTGACGTTAAAAGGGTAATCGTTGCTTACCATACTGAGACGAGAATAAAGAGGAAGTCTTCTCTACGAGACACCAGTGACGTCTACTCTGAAAAGGCCTCGTTTTCTGTCTGGTACAAAATGATAAGCTTCATGCTATAAACTGTTCGGTCTCAGAAATTGCCGATGGTTCTAGGCGCCCATGCCTACTACGTGCTGTCCTGACTGACCACCTGACTTATGGACTTCGTCAACACATCACCAACACACTGGAGGGAGGCCAAGAACAGGCATTGATAGGGGAGAGGTCAATGACATGCATCGATAAACAGATAGGGAGTGAATGGAAGGGGGCAAATGGAATATAAAGTGTTTAAAGGCAAGTGGATATATAAGAAGACTGAGGACAGAAGAAGATCGGATTTCCGGAACAGGGGGATTTATCAGCGTCCTAGCATGGGTTGATCCAGAGCGACTATCTCTTCCTGCCAGCTTAAAAAATTCTGGAAGCGCTTGACCCTGGGATCGACTCCCTTCGATGCCCATCGAATGCTCCGAAGTTTTATGTCGACGCTCTGCCTCACGTAGCCAAATCCGGCTGCCCTTCGCCCCCAGCTATAATTCGTGCGAAGGCCTAGAAGTGGGACAGTCCTCTCCCTTCCCGCGATTATAAGGGAATTGTGAAAGTATAAAACTACTACATCTGCTTTGAGGGATCAGTACATCTGCGAAACGAGCTTGGTTCACGTACTGAGATAGTGCAAATTACTAACACATATTTTAGTTAGAGATGCCTGATATTTTAAGTGTGCAGCTAAAGTAATAAAAATTACTTATAGAGTAAATCTCAAGAGATGCAAAGGTCGTTGTACAACCTTCACTGGTACATTTTAAGCGCTTTCGATTACATTATCCTGAGTAGCATCAGTGAAACGACATGCCGCGAAGATAGTGAGCTGTCTTGTTAAGAATGATTTCCTGAGCTACGAACCATTCCACGCAACAGTCTAATTATGACAACCGTCACAGGAAGGCAAAATAATGTTCTATGCTTGTTCTTGGTATGTAAGCCGTGCGTTCTTGGTTTGTGACAGAGAGCGCGATCTACCTTGCTCTTCTATCAATGCCGATCGTGCTCTGCTGACTTTCAGCACTGTCTGGTCAAGTCTTCGAGTGTCCACCGTAAGCATGGCATCTCGGCACTGCAGAGCTCTGTGTGCAGCGCTCAGTCTCGGATGCAGGAAGCATCAGGTTGGAGCCAACTCTTTGTGTGCTGAGTTTGCACACGCTATCTCCTAATTCTGTGGGAATGTATGATGCGATCTCTATAGATCCTGAGTCCCTACGCTAGCGCTCAGAGAGGCACAGCCACGCAGAGAGTTAGAATAAGTCAATGATGTCCCTGCACTCTGTGAAGGTGCGTATGAAGCCATACCTTGACCATGCGTCATGGCTAGCCATTATGCCGTGCCAGGTACTTGGATCCGTGCCTCGGGAGGGTCTCTCTTACGCCCAAGTACCACACGTATAGCTCTCGGAGGTGAACTAGCACCCTGGTACACTTCTTTGGAAGGCTCTACCCATCTACGCACTTACTCGCGGTTGAGACGGCGACTGTACGCTTCCCGCGGATGCTCCAACGTGAGTAGCGGGCGAGCATGGCTGGCTTCCGTCTCGCCCTCTTTAATTATTATAGCGGACATTAAGACTTAATTACCCCGCACCTGAGTGGACGTGCCCCATCATAAACATGAGGACTACAACTACGATAAACGAGGCAGAAAGCAAGCAGCTGAATGAAACCAAAGCGCAACCTCCTAATTAAGAAGCAAGGTGCATCTGTTTGTGCAACGCCGTCCAGGTCAGGCACTAGTCTGGCCTCCTGAGTTACCGCCTAAGGAATGCGTTCGAAAATCGGAACCTCACCTCACGTTGGGCCTACAGAGTGTTGGAGGAGAACATCAACAGAAAAATTGTACAGCGTTCACCACCTAATCTCTTGAACTTCAGGCTGTGAAAAGGCATCACCATTTACCAACTGTCAGGCCACCTCCAATGCCGACATATGCTGTTGGACTCACCCCAGGCCGGACCCTCGTGGTTCTCAGGGCCAGGTGCACAGACGTCCTCACGTTCATCCCTCCACCCTTGGACTTTCTTTCGCCGTGATGTGACACCGCGCTTTGCTGGGCACTGGCGAGGAGGCACCAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAACGCTTCCTAGTTTTTTTTTTTTCTGTCCTCTCTCACCTCCTAAAGTAGACTTCATTTCCTAACAGGATTAGACAGTCAGGAGTGCTTACTCCGACATGTGGGAGCTTATGGTAATGAATGCGGGCGGCAGCTGTAAGAGTCCAACGTGGGGCAGCACCAGAAGAGCCGGGGCATGCCCCAGGTCGGGCTGCCCCAACCCAATACTGAATCGCGTGTGGCAGGGAGAAAAGAGGCAAATGTGGCGGCAATGCCTCACACAGGCACATGGGTCTCCTGGAGATTTGGGGTGAGGATGTGTCAGCAGGCGGCCTCTGGACGTCAACTGTTGCCTCTGCATGGTCCCCAGAGCAGCCTCTACGAACAACTCCGTTCAAACCAAGAGCCAGCCGGAGAGTCCAGGAAGACTTACCCTCCAGAGCAGAAGGTAGATCCTCCTGGACAGCTCAAGCAGCGCGCCAGCACCCTTAGACACTGGCTGGACGCGCGGTGCAGGCAGGCAGTGCACAGTGGCCAGCCACTAACCCTCCCTGAAGAAATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTTTCGTAGCGAGTAGGCACAGGCGTGCACCTTCCGAATTACTGCACCGGACACACGGGCAGACGCGGAACGGCCCGGTTGGTGGAGACAGAGAGAGCCTCTGACCACATCCCTCCTAACACCTGCTGACACTCTCCTTTTGCTCCTCCCTCGCGCTAACTACGCCCACCTTTTGATTTTAGCGCCCCGTGATAGGCCTTCCAAAGAGCCCCACGCTTGGCTATCACCCTCCCCGAGACAAGATGAGAGTATCAGCTGATGCCAAAACGCGTACTTCTTAATCCACTCTAAATCCTAATGTTCGTTGGGCTTAATATCATGTCTATAATATATAGCCTCGAAGATGAGAAGGGTTACAAAGAACAAAATCCAACACAAACCCCCACATTTTCAGCAGACATCTGCGTCGCTTTGAGCTGAAGGTCGGCTCGCATCCATACGTGGCCGCACCCAAACAGCACGTGGCTGGTGACGATGGCTGAACGAAAGTGTACTGTTCCGAAATGAAAAAATAAACTAATAACTTATAATG 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@rCer/979/1710_56_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGATAATGATATCGCTCTTCATCATAGCCGCCTCATTGCCTCAAACACACCTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTCC 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8684-42%&-3(2(/339:46030+231.0.&98/222:5579::26889081><:;31:4<=:3)659:;.=<7==78?6;:979;>8;;<88>1<3;;:;:>>799.08;87248-1<8)<98*9=;99<929.4;,:98?;<7167801:7:6%&;0/:;9%7;4:6?1=85.5858;);60=:88.66,781.5$7:66=9=679;?=8+17::605487<1>===4749=07523>93;=735.4586;.2;:<2;6<9?;:08<<0;;;36-7;:=>77;>?7>;:9:>3<><<,/0%7+::*>:/8.;-?:49:=433)6;?8;9<463;*4908788598%30*;76:8<9533-:;925?:?9563399:6;;:=4<5;:><9=8:-483:::9-?:06>;;4<:518/>7;;.6.9,88?6=/>9<7<6>>78::;81;/>779:83*3;56;725;9.74=;<77.235;9(:?6=:6:904649==,;9171482:6<615398<;:3164:1<,>A6>148423,0,8:9<=?>4?26><@;*689;8>?03==13<;;8<94<@6B74<12<;?:9=?1>@@8C9;/:?53+$579.<245?<=8/269696107-9==8<9;978;=/=9=9771678+789,6203#46.76<<*267.311:,9865>=;==9518428-782<2;53/;7=3>;2=9;9.<7;8<3<>;?<9896.5875246193,65=0836836374%6895;/5;6;<9:;6:8762,2/4'-5,0856;5<4((650702:0<78408<<95/44%*2)4308;883.:;:%2.9+713::4:28:8;1-2088+6<:6;8-:;:=<294)7555>:+6735-<05925014685'1;:;879%;6978/88*757;:>54785#2;2:8267616=3+;<.56;5<1:6'=;654*:9295309>=>=>;>621?234:>:859,=4=>=>?.:2/6+318-0+:6,4937=571738-1:28127:/:::9<;><==747502+).3.7908317807=>>?:<83:045;2<)($24<)4/539;<2757/:8:7;-95/253%69?88779<':793822;281./.12)4/5>?569972403+::===261;3:0;9-24;>0>6<=33=9<,6/>;3;<*78985=2810:875534568<9717;60-69=6)-0$0-0-2,76<=919*1-37405.8'/5/5500+:.).242229(;7;867868:6836;8:4?:?79;=3;394;9*6477316/<6665:=;18:8=:888:(788*19=30::.35/<6<8375731<;37878956/:946422<=98=?<80;4:+9=7+92>2<498;4::,;;889;78$6?7455;2>2=>659;;0<98;2:<7:+<<4(2185649/5487059+-942859879-0*:377?:6.:<89<6(3>=8;28152981:268/894%57:-68<9=4 @rCer/980/25_1823_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACC + HE?IKHCBCHHKJFDE45/65=@:I;DGIKE6IJHA?IKHBI?KEBFG4KKJIKKC;4ED?FG:HKJGEEEHD9DKIEIJHKBCBDIGGJ=J@KJ@KIJK?AJJGH8BGBGEHE;8EJIDHIK@J=FIHDJKJKJ>KKJDKDKJAFJFFK?HJHHKHKJKK9KIKKGAKFHKJKIGH2IKHIIJAIFGDFIKJJC+ECHIBKIHJHC>JIJKJKKJKJIKCKJJIFGH0>DC?GJJKJJHCAIJK9KFHJAEKI;FHKIBKJJFKD=KKCGI:GGAIDCK;@G:KJJKG7GC;6>I@8C<:@DDGCGCBCFIBHIGJJKKJJEJJKGKFAFK5HHIIKIJ:K8GJGGFDBJCJIEBFFFKJKIJCFEKJJIJKJKKKJHDCHKJIIHDKEACKJKKHGKGJKFIIFKKKIJEIKEKJJJFJKDJIKGKEB?FKFKIJKJJKJJFFHGKFD>IHDJ@H@KKJIIGKKKJIKHHGFFG@IFG%GIA:H=AGJJDHD4FKKHFGHAF?JEFKKICKGKHFFKJ;KIGKGIEDCEHCKDGKI:IJEIB?KGJ@BEBIGEDKEKII;C=JI19GFCCEA9JKJ?J8KJIBJKJKEID3CCJGIBHDCJJGFGJC>K:FJIJJDGJKIGH,A?=A>GKCKJHHKKCKHIBJHJKGKDFKJ?BIJA=IDDBHFBJBAK>HIHKAAI@GGIJFGFJKKIKIE@IKJJEJ?AJGJJJ?KHDIIKKKJKKKKKKJKKKKKHFKKKFKEFDCHJGJKFGHG@G:?EKGJFJEFJIJKIJJ=KKKJJKJKDKKKKIK/KJEKHDKKDJHGKHJJKHKJKJKCKJKHKDJIFKIKJHKJBJKKHKFE>AIKKJKJIKJGKJJKJKI5KKKKGKKJKGEKGCKKKHGKJKJJKJH@KKK=KKKKKKKH4IDJF;CFEIH+HIHKKKJGHIGKJKKKHCIFDJ?IKH@AKKDKGKKJJGB@GHKJ?GKJFICGDJJJJ;IHDJKIKKJ:JJG@JGJH=B;-JF7DFDB9/CJB6:GKKKIJKGEEDJK=FGIHKHEF3IKKJI@;JKHICKKKK8KKJFKKK@JJAIA@IDHHCKE;KKKGFK5IJKK?C%AGEC8GHJKHFJBJJKIKIGKKKD1GCJ=IJBJBGKI5KKHIJIHKIII;GIIIGCGF>HI8AHHIKIKIFIICHD:JBHFJHIECGGKKHBJI@IFEIJIDE>JDB @rCer/984/2829_57_CCS ATGGGGATTCCTGGGAGGACTGCCGCTCGTTCGGACGTCTTTCCTGTCGCTGGAGGAGACGTCCGGGCTCTCCGGGAAGGCGGCTGCGCAACAAAATGAAGATATTCGTGGGCAACGTCGACGGGGCGGATACGACTCCGGAGGAGCTGGCAGCCCTCTTTGCGCCCTATGGCACGGTCATGAGCTGCGCCGTCATGAAACAGTTCGCCTTCGTGCACATGCGCGAGAACGCGGGCGCGCTGCGCGCCATCGAAGCCCTGCACGGCCACGAGCTGCGGCCGGGGCGCGCGCTCGTGGTGGAGATGTCGCGCCCAAGGCCTCTTAATACTTGGAAGATTTTCGTGGGCAATGTGTCGGCTGCATGCACGAGCCAGGAACTGCGCAGCCTCTTCGAGCGTCGCGGACGCGTCATCGAGTGTGACGTGGTGAAAGACTACGCGTTTGTTCACATGGAGAAGGAAGCAGATGCCAAAGCCGCAATCGCGCAGCTCAACGGCAAAGAAGTGAAGGGCAAGCGCATCAACGTGGAACTCTCCACCAAGGGTCAGAAGAAGGGGCCTGGCCTGGCTGTCCAGTCTGGGGACAAGACCAAGAAACCAGGGGCTGGGGATACGGCCTTCCCTGGAACTGGTGGCTTCTCTGCCACCTTCGACTACCAGCAGGCTTTTGGCAACAGCACTGGTGGCTTTGATGGGCAAGCCCGTCAGCCCACACCACCCTTCTTTGGTCGCGACCGCAGCCCTCTGCGCCGTTCACCTCCCCGAGCCTCTTATGTGGCTCCTCTGACGGCCCAGCCAGCTACCTACCGGGCCCAGCCGTCAGTGTCACTGGGAGCTGCCTACAGGGCCCAGCCTTCTGCCTCTTTGGGTGTTGGCTATCGGACTCAGCCCATGACAGCCCAGGCAGCCTCTTACCGCGCTCAGCCCTCTGTCTCCCTTGGGGCCCCATACAGGGGCCAGCTGGCTAGTCCTAGCTCCCAGTCTGCTGCAGCTTCTTCACTTGGCCCCTATGGTGGAGCCCAGCCCTCGGCCTCGGCCCTTTCCTCCTATGGGGGTCAGGCAGCTGCGGCTTCTTCGCTCAACTCCTATGGGGCTCAGGGTTCCTCCCTTGCCTCCTATGGTAACCAGCCATCCTCTTACGGCGCCCAGGCTGCCTCTTCCTATGGGGTTCGTGCAGCTGCTTCTTCCTACAACACCCAGGGAGCAGCTTCCTCCTTAGGCTCCTACGGGGCTCAGGCAGCCTCCTATGGGCCCAGTCTGCAGCCTCCTCACTAGCTTATGGAGCCCAGGCAGCTTCTTACAATGCCCAGCCCTCGGCCTCTTACAATGCCCAGTCTGCCCCATATGCTGCACAGCAGGCTGCTTCCTACTCTTCCCAACCTGCTGCCTATGTGGCGCAGCCAGCCACAGCTGCTGCCTATGCCAGCCAGCCAGCAGCCTACGCCGCACAAGCCACTACCCCAATGGCTGGCTCTTATGGGGCCCAGCCAGTTGTCCAGACCCAGCTGAATAGTTACGGGGCCCAAGCATCAATGGGCCTCTCAGGCTCCTATGGGGCTCAGTCGGCTGCTGCGGCCACTGGCTCCTATGGTGCCGCAGCAGCCTACGGGGCCCAACCTTCTGCCACCCTGGCAGCTCCTTACCGCACTCAGTCGTCAGCCTCATTGGCTGCTTCCTATGCTGCCCAGCAGCATCCCCAGGCTGCTGCCTCCTACCGCGGCCAGCCAGGCAATGCCTACGATGGGGCAGGTCAGCCGTCTGCAGCCTACCTGTCCATGTCCCAGGGGGCCGTTGCCAACGCCAACAGCACCCCGCCGCCCTATGAGCGTACCCGCCTCTCCCCACCCCGGGCCAGCTACGACGATCCCTACAAAAAGGCTGTCGCCATGTCGAAAAGGTATGGTTCCGACCGGCGTTTAGCCGAGCTCTCTGATTTACCGCCGTTTATCAGAGTCGCAGCTTTCGTTCCGCCGCTCGCCGACAAAGTCCTCGCTGGATTACCGTCGCCTGCCCGATGCCCATTCCGATTACGCACGCTATTCGGGCTCCTATAATGATTACCTGCGGGCGGCTCAGATGCACTCTGGCTACCAGCGCCGCATGTAGGGCCATCCTGGGATGGGGCACCACAGGGCGGGAGGGAGAAAAGAGGTGGGTAGGGTTACAGATCCAGGTTATAACTACTCTGGCCATACCTTTCCTGGTTGTGGTTTTTCATCCCCTCTACCATGTGGGCCTTCCCCAGGAGATGATCCTTTTGAGTGTTCGGCAGTAACCTACTTTGTTCCTTCGCCTCAGCAGCAAATCTTGCTACTGGCTCTAGATCTGCGGTTTTCCCTCTGCCCTGCCTCCCGTCTCCCAGAATGGGAATTTCTTTTATGTTTTTATTTTTTTCCTGGCTCCTTTTTATTTTTGTGCGCGATATTTAAGGTCGTCTGGATGGGGAAGCAACCTGCAGCTGAGGTCGCCGGCGCCTTTTTCTTTTTAGATGGAAGGAGGCCAGGAAAGGGTTAGCTTAACCATTTCCTATGCGCCAAGCTGTGCCAGCAGTCCAGGGTACCCTGACTGTCCCTCTGTAGACTGTTGAGAGTGAGTTCTTGTTGGGACAGTCAGTTGGCATGTATCCAAGTCCCTGCTGACCGCTAATGTTCTAGCTGATGGTGAGCGGCACAGTCCCACTTCCCCATCTCCCCAAGTAGTGGTGTTAGAAAACCTTAATTTTTTTTCCCTTTTGTATGGACTACAAATAAAAACTTGGGGCAATTTGCAGTTT 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@rCer/989/2281_56_CCS TGGGACGAATTAGCTAAGTTATTAAAGATGGCGGCGGAAGCGCAGTCGCTCGCGATGGACTCGCCGGTCCCGGCCTCTATGTTCGCCCCCGAGCCCAGCTCCCCGGGGGCGCCAGGGCCGCGGCGGCGCCGCCCGACTCCACGCGGCTTTGACTCGGACTGCAGCGAGGACGCGAGGCGCTCACGGCGAGCCAGAGCGACCTCAAGCAAGCTGGTTCTATGAGCTACTTCAGAGCAGTATGACAGCCTACTTCGGCAGATGTGGGAGAGGATGGACGAGGGATGCGGAGAGACCATATATGTCATTGGCAGGGATCAGATGGGACTGAGTATGGCTGAGTGAAGCTGACATGGAGGCCTCCTACGCCACAGTGAAGAGCATGGCGGAACAGATAGAGGCATTCATCCTTCTGCGGGAACGGCAAGAAGTCTGGGGACGCGTGCGTGATTACCTGGTCCGGAAACGAGTAGGAGACAATGACTCCTGGAGGTCAGGTGTAGCAAGTGGTGGGCAACGTGGATGCTGGCAAAAGCACGCTTCTGGGTTCCTGACACATGGGGAGCTGGAACAATGGCCGAGTTTTGCCCGCCAGAAACTCTTCCGCCACAAACATGAAATTGAATCTGGTCGCACCAGCAGTGTGGGCAACGACATTCTGGCTTGACAGTGAAGGCAATGTAGTGAACAAGCCTGACAGCCATGCGGCAGCCTGGAGTGGACAAGATTTGTGAGAAGTCCACTAAATCATTACCTTCATCGACTTGGCTGTCATGAGAAGTACCTGAAAACTACTGTCTTCGGCATGACAGGCATCTGCCTGACTTCTGCATGCTCATGGTGGGCAGCAATGCGGCATTGTGGGGATGACCAAAGAACACCTGGGCTTGGCACTGGCATCAATGTACTGTCTTTGTGGTAGTCACCAAGATTGACATGTGTCCTGCCAACATCCTGCAAGAAACCCTGAAGCTGTTACACGCCTGCGAAGTCACAGGCTGCCGGAAGATCCCCGTGCTGGTGCAGAGCAAGGATGATGTGATTGTCACAGCCTCCAACTCAGCTCCGAAAGGATGTGCCCGATATTTCCAGATCTCCAATTTACAGGCGAGAACTAGATCTGCTGAAGATGTTCCTCAACCTCCTCTCCCCCGCACAGCTACAGGAGGAGGAGCCTGCTGAGTTTCAGATTGATGACACCTACTCCGTCCGGGTGTGGGACAGTGGTGTCGGGACAACATGAGAGGCCTGATCAAGCTGAATGACACACTGCTGCTGGGCCCAGACCCTGGTAACTTCCTGTCCATTGCTGTCAAATCCATTCATCGCAAGCGCATGCCTGTCAAGGAGGTGCGGGTGGCCAGACAGCATCCTTTGCGCTGAAGAAGATCAAGCGCTCGTCATCCGGAAGGGCATGGTGATGGTTTCCCACGTTGAATCCCAAGCCTCCTGGAGTTTGAGGCGAGATTCTCGTCTCCACCACCCCCACAATTAGCCGCGCTACCAGGCATGTGCACTGTGGGAGCATCAGGCAGACAGCCACCATTCTGAGCATGGACAAGGACTGTCTGCGCACTGGGACAAGCACTGTACATTTCCGCTTCATCAAGACCCTGAGTACCTGCACATAGACCAGCGCTGGTGTTCGGGAAGGCCGCACCAAGCTGTCGCACATCACAAGCTGCTCCAGACACCAACAACTCCCGATGAACTCCAAGCCCAGCAGATTAAAATGCAGTCGACGAAAAAGGGCCCCTGACGAAACGAGACGAGGGGCCCATCTGGCGGGCCAGCAGTAGGAGCACCCCACCTGGAGATGAAGCTTCCTGTCTAGGGGCTGGCACCAGCTGCGTCAGCAGTCTCCAGCCTCAGCCTAAGCCAGCAGTGGAGGCCGGCGACGAGGGGGCAGCGCCACAAGGTGAAGTCCCAGGGGCCTGTGTGACTCCTGCAGCGGCTGCTGAACCTTCTCCTGGCCCACCCCACCACCCAAGGGTCATCATACTCTGGCCACCGCTCCACCAGATGGCAGAGCAGCTATGACCGCCACCCAGCCCTCCTGCTCAGGCCACAGCCGGAGCCTCCGCATTGCCCCACCCCATTTTCCAGGGGGTTGTAATTTATAAGCTGAGGAAGCAGCCAGACCTGGAGGACTGACCATCTCCATGTCCTCCCACCTTCTTCCTCACTCTCACATTTTTTGTAACATCTGGCCCTTAGTTTTATTCTGT 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@rCer/993/25_2647_CCS ATGGGGGAAGCCGCGGCGGAGCCCGAACCCCGCAGCCTGAGCCACCTTCGTCATCTGGGCCGGGCCTCGCCGCGCAGGAGCTGCCAAGGCCATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACGGGGGCCCCACACTGAGCCTACCCCTGCCTCTGCACGCTGCCCATAACCAGCTACTCAACGCCAAGCTGCAGGCCACAGCTGTGGGACCAAGGACCTGCGTAGCGCCATGGGGGAGGGTGGTGGGCCTGAACCAGGCCCTGCCAATGCCAAGTGGCTAAAAGAGGGCCAGAACCAACTCCGGCGGGCCGCCACGGCCCACCGTGACCAGAACCGCAATGTGACCTTGACCTTGGCGGAGGAGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCAAAGGCCTGATACACCTGTACTCTGAGCTGGAGCTCTCAGCCCACAACGCGGCCAACCGAGGCCTACGAGGACCTGGCCTGATCATCAGCACTCAAGAGCAGGGGCCAGATGAGGGAGAGGAGAAGGCGGCAGGGGAGGCTGAGGAGGAGGAGGAGGAGGATGATGATGAAGAGGAGGAGGAGGACTTATCTTCTCCCCCAGGGCTGCCTGAGACCCTGGAGAGTGTGGAGGCCCCTCCCAGGCCCAAGCCCTTACAGATGGCCCCGGGAACACAGCAAGAGTGCCAGCCTGCTGTTTGGCATGCGGAACAGTGCAGCCAGTGACGAGGACTCAAGCTGGGCTACCTTATCCAGGGCAGCCCCTCCTATGGCTCCCCAGAGGACACAGATTCCTTCTGGAACCCTAACGCCTTCGAGACGGATTCCGACCTGCCGGCTGGATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCCAACAGGGACCACCCAGTGGGAACCCCCCGGCCGGGCCTCCCCCTCACAAGGGAGCAGCCCCAAGAGGAGTCCCAGCTCACCTGGACAGGTTTTGCTCACGGAGAAGGCTTTGAGGATGGAGAGTTTTGGAAGGATGAACCCAGTGATGAGGCCCCAATGGAGCTGGGACTGAAGGAACCTGAGGAGGGGACATTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCATTGCCCCAAGAGGAGGAGAAGCTACCCCCACGGAATACCAACCCAGGGATAAAGTGTTTCGCCGTGCGATCCCTAGGCTGGGTAGAGATGACCGAGGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTGCATCCGTCAGCTCTCTTACCACAAAAACAACCTGCATGACCCCATGTCTGGGGGCTGGGGGGAAGGAAAGGATCTGCTACTACAGCTGGAGGACGAGACGCTAAAAGCTAGTGGAGCCACAGAGCCAGGCACTGCTGCACGCCCAACCCATCATCAGCATCCGTGTGTGGGGCGTTGGGCGGGACAGTGGAAGAGAGAGGGACTTTGCCTACGTAGCTCGTGATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCCGCCAAGAACATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCCGAACGGCGTAATGCCCGCTGCTTGGTGAATGGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCCTTTCCAAGTGGAATTCCCAGCGCCTAAGAATGAGTTGGTCCAGAAGTTCCAAGTCTATTACCTGGGGAATGTACCTGTTGCTAACCTGTTGGGGTAGATGTGATTAATGGGGCCCTCGAGTCAGTCCTGTCCTCCAGCAGCCGTGAGCAGTGGACCCCAAGTCATGTCAGTGTGGCTCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGGTGCGTTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCCACACATTTGCATTCATCATGGCTGCCGGCCCAGCCTCCTTCTGCTGCCACATGTTTTGGTGCGAGCCCAATGCTGCTAGCCTCTCAGAGGCTGTGCAGGCTGCGTGCATGCTTCGCTACCAGAAGTGTCTGGATGCCCGTTCCCAGGCCTCCACTTCCTGCCTCCCAGCACCCCCTGCTGAGTCCGTGGCACGGCGTGTAGGGTGGACTGTCCGCAGGGGTGTTCAGTCGCTGTGGGGCTCCCTGAAGCCCAAACGGCTGGGGACCCATACCCCATGAAGAAGCCTCTGCCTTCCCTCCACCTGCTTGTGTCGGGCCCCAGGGAACTACAGGGTGTGGGTCAGGTAGGGGTCTAGAGGCTATTCCTAGGCCTTAGGCCTCCCAAATATGCCCCTCCCCAGTAGCTAGGGTTCCCTGCCTAGGAGCTGGGGAGGGAGAGATCTAATCCTTCAAGGAAGTCATAACACTGGTGTGGTAACAAGAGGAGCAGGAAGCAAGGCCAGCCCTGGCTCTCCATCCCCATGTGTTTCAGGTGGAACAGGAGGAACTGGCCCAGGCCAGGCCTCATACTCCTGGGACCCAGCAGGGGCAGGAGGAAGGGACTGGTCCAGGCATGGGTCCCTTCCCTTTGCTCCGTGGGCACCTCTACTGTATTGATATCACTAATAAAGTCTGTCTGCACT 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rCer/995/1848_58_CCS ATGGGGCAGGTGCAGGTGCAGGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATCTGGTCACTGGTGGGGAGCTCTTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTCGGCCTGGCTATCGAGGTGCAGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGATATCTGGGCATGTGGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCGAATGGGACACTGTCACTCCTGAAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGAATTTCTCAGTGGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGCCCCAGACGAATAGCACCAAAAACAGTGCAGCCGCCACCAGCCCAAAGGGACGCTTCCTCCTGCCGCCCTGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCGCACCAGCCAGTCTGAGGAGACCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGAGCTGCGCCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCCGACTGCCCTCGGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCCTGGTGCCTGTGTCTGCAGAAAAACAAGACCAGATGTGATTTGTTTAAAAACAAAACAAAACAAAAAAACAAGATGACGACGACAACCACAAAAAAATTGACATCAGAT 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@rCer/997/1598_54_CCS TGGGAACTTAGAGCCGACCTAGAGCTGGAAGTGGCGGCGTCGTGGTCTGCCGGGCTGCTACTCCGGGGCACAAGTGCTATTGCGCGCCCGCCGCTCGCCGACCCTGCTGCGGACGCCAGCCTTGCGGAGTACGGCAACTTCGCTCAGGCGCTCCAGTTCGTGCCGGAGACGCAGGTTAGCCTGCTGGACACGGCCTGCGTGTGGCCTCCGAGCGTCCTCTCAGCCCATTGCACGTGGGAGTGTGGATTGATGTTGGCAGCCGTTTTGAGACTGAGAAGAACAATGGGCAGGCTACTTTTTGGAGCATCTGGCTTCAAGGGAACAAAGAATCGGCTGGCAGTGCCCTGGAGAAGGAGGTGGAGGCATGGGGGCCATCTTAATGCCTACAGCACGCCGGGAACACACAGCTTACTACATCAAGGCGCTGTCCAAGGATCTGCCAAAAGTTGTGGAGCTCTTGGGTGACATTGTGCAGAACTGTAGTCTGGAAGACTCACAGATCGAGAAGGAACGTGATGTGATCCTGCGGGAGATGCAGGAGAATGACGCATCTATGCGAGACGTGGTCTTGACTACCTGCATGCCACAGCATTTCCAGGGCGGACCACCTCTAGCCAGGCTGTGGAGGGGCCAGTGAGAATTCAGAGCTGTCTCGTGCAGACTTGACCGAGTACTTCAGCACTCATTACAAGGCCCTCGAATGGTGCTGGCAGCAGCTGGAGAGTGGAGCACCAGCAACTGTTAGACCTTGCCAGAAGCACCTTGGTGACATCCTTGGACATACGCAGAGGACACGTGCTGCTCTTACTCCGTGCGCTTCACTGGCAGTGAGATCCGCCACCGTGACCGATGCTCTACCTTGCTCATGTGCCATTGCAGTAAGGGTCCTGGCTGGGCCAGCCGGACAATGTGGCCTTGCAAGTGGCCAATGCCATTCACGGCCACATGATTGCACTTACGGTGGTGGCGTGCACCTGTCCAGCCCACTGGCTTCAGGTGCCGTGCCAACAACTATCCAGAGTTTCCAGACCTTCAGCATCTGCTATGCAGACACGGGTTGCTGGGTGCACACTTTGTCTGTGACCGAATGAAATCGATGACATGATGTTCGTCTGCAAGGCAGTGGATGCGCCTGTGTACCAGTGCCACGGAGAGTGAGGTGGCCCGGGGCAAAACATCCTCAGAAATGCCCTGGTATCCATTCTAGATGCACTACTCCTGTGTGTGAGGACATTGGTCGCCAGCCTCCACTATGGCAGCCGCATCCCCCTGGCTAAATGAAAGCTGGATTGCGGAGGGGTGGATGCCAGTGTGGTGCGTGAGATCTGCTCCAAGACATCTATGCCAGTGCCCAGCGGTGGCTGGATATGGCCCATTGAGCAGCTCCAGACTACAACCGGATCCGTAGCGGCATGTTCTGGCTGCGCTTCTAGGCGGAAGCCTGTGTAAACAAGAGAGCTGGCTGGGGCTCGTGTCCCCCACCACAAACACAGCACTCGGCTCCTCTAACCGTGCCGCAGGTGACCACCATAAAAATCTTCTGC 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@rCer/1000/1928_56_CCS ATGGGGCGTCGAGCCTCGGCGGCGGCGGCGCTTACACCTTGAGAGGAGCGTCTCGCCCGGGAGCAGCGGCGGCCATCGAGACCCACCCAAGGAGCGTCCCCTCGGCCTCCCAGCGCTCCCAGGCCGTAGCGGCTGCGCCCATTTAGCTAGCTTGCTCGCTCGCTCTCCTTCCTGCTGCCGGCTGCGCCATGGCGTTGGCGTTGGCGGCGCTGGCGGCGGTCGAGCCGGCCTGTGCAGCCGTACAGCAGTTACAGAATGAAGAAGAGTCTGGAGAACCTGAACAGGCTGCCGGTGATGCTCCTCCACCTTACAGCAGCATTTCTGCAGAGAGCGCAGCATATTTTGACTACAAGGATGAGTCTGGTTTCCAAGCCCCCATCTTACAATGTAGCTACAACACTGCCCAGTTATGATGAAGCGGAGCGGACCAAGGCCGAAGCTACTATCCTTTGGTTCCTGGAGAGATGAGGATTTTGTGGTCGGGATGATTTTGATGATGCTGACCAGCTGAGGATAGGAAATGATGGGATTTTCATGTTAACTTTTTTCATGGCATTCCTCTTTAACTGGATTGGGTTTTTCCTGTCTTTTTGCCTGACCACTTCAGCTGCAGGAAGGTATGGGGCCATTTCAGGATTTGTCTCTCTCTAATTAAGTGGATCCTGATTGTCAGGTTTTCCACCTATTTCCCTGATATTTTGATGTCAGTACTGGCTCTGGTGGTGTTCCTGGTTTTAGGCTTTCTCCTGTTTCTCAGAGGATTTATCAATTATGCAAAAGTTCGGAAGATGCCAGAAACTTTCTCAAATCTCCCCAGGACCAGAGTTCTCTTTATTTATTAAAGATGTTTTCTGGCAAAGGCCTTCCTGCATTTATGAATTCTCTCTCAAGAAGCAAGAGAACACCTGCAGGAATGAATCAAGATGCAGAACACAGAGGAATAATCACCTGCTTTAAAAAATAAAGTACTGTTGAAAAGATCATTTCTCTCTATTTGTTCCTAGGTGTAAAATTTTAATAGTTAATGCAGAATTCTGTAATCATTGAATCATTAGTGGTTAATGTTTGAAAAAGCTCTTGCAATCAAGTCTGTGATGTATTAATAATGCCTTATATATTGTTTGTAGTCATTTTAAGTAGCATGAGCCATGTCCCTGTAGTCAGTAGGGGCAGTCTTGCTTTATTCATCCTCCATCTCAAAGTGAACTTGGAATTAAATATTTTATTGTAAGATATGTATAATGCTGGCATTTTAAAGGGTTTTCTCAAAAGTTAAACTTTTGTTAGTATGTTTTTGCACATAATCCATATTTGCTGTTCAAATTAATCTAGAAATTTATTCAATTCTGTGTGAACACCTGGAAGCAAAATCATAGTGCAAAAATACATTTAAGGTGTGGTCAAAAATATGTCTTTAATTGGTAAATAATAAGCGTTAATTTTTTATAGCCTGTATTCACAATTTTGCAATACTTTATTGTACCTAAGGGATTCTAAAGTGTTGTCACTGTATAAAATAGAAAGGACGAGGATACAAATGAAACTTAATTACTAAAATGTAATTCTTGACACTCTTTCTATAATTAGAGTCCTCACCCCATCCCCACCCACCCCCCCTTATTTTCCTTTTATCTCTGATGATTAGGCCAAAGGCTGGAGTAAGGAGAGGATTAGGTACTTAGAGCAAAGAAGTAGCTTGAACTTTTGAGATGATCCCTAACATACTGTACTACTTGCTTTTACAATGTGTTAGCAGAAACCAGTGGGTTATAATGTAGAATGATGTGCTTTCTGCCCAAGTGGTAATTCATCTTGGTTTGCTATGTTAAAACTGTAAATACAACAGAACATTAATAAATATCTCTTGTGTAG 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@rCer/1010/26_1994_CCS ATGGGGCCCCCTCCCCGCCTTGTTGTCCAACTTTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCCGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATTGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGACCAGCTTGCAGACATGATCCCTTGCGTCCTACAGTACTAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTTGATACAAAAGTACAGAAATATCATTACACATGCACCAACCTGGATAACATTGATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGCCTCATCCTGCATGACTCGCCTGTCCCGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTCTCGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGCTGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGAGACCTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGGTGTAAAAAGGAAGTTGAATGGGAATGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAAACAGGAAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGCTGGGCTACTTGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGCTCTGAACCACACTGTTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT 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@rCer/1011/1852_54_CCS ATGGGGCTTCCGCCTGGCGAAGGAGCTGAGGCATGGCCTTCTTCTCCAGCTGAGAGGACGATCGTCCTTATAGGAGAGCCCGAGTCTCGGAGGGCAATTTCGGAGGGAAGCAGAGACTTTCAAGGAACAAGGAAATGCATACTATGCCAAGAAAGATTACAATGAAGCTTATAATTATTATACAAAGCCATAGATATGTGTCCTAAAAATGCTAGCTATTATGGTAATCGAGCAGCCACCTTGATGATGCTTGGAAGGTTCGGGAAGCTCTCGGAGATGCACAACAGTCAGTGAGGTTGGATGACAGTTTTGTCCGGGGACATCTACGAGAGGGCAAGTGCCATCTCTCTCTAGGAAATGCCATGGCAGCATGTCGCAGCTTCCAGAGAGCCCTAGAACTGGATCATAAAAATGCTCAGGCACAACAAGAGTTCAAGAATGCTAATGCAGTCATGGAATATGAGAAAATAGCAGAAACAGATTTTGAGAAGCGAGATTTTCGGAAGGTTGTTTTCTGCATGGACCGTGCCCTAGAATTTGCCCCTGCTGCCATCGCTTCAAAATCCTCAAGGCAGAATGTTTAGCAATGCTGGGTCGTTATCCAGAAGCACAGTCTGTGGCTAGTGACATTCTACGAATGGATTCTACCAATGCAGATGCTCTATATGTACGAGGTCTTTGCCTTTATTATGAAGATTGTATGAGAAGGCAGTTCAGTTTTTCGTACAGGCTCTCAGGATGGCTCCTGACCATGAGAAAGCCTGCATTGCCTGCAGAATGCCAAAGCACTCAAAGCAAAGAAAGAAGATGGGAATAAAGCATTTAAGGAAGGAAATTACAAACTAGCATATGAACTGTACACAGAAGCCCTGGGGATAGACCCAACAATATAAAAACAAATGCTAAACTCTACTGTAATCGGGGTACGGTTAATTCCAAGCTTAGGAAACTAGATGATGCAATAGAAGACTGCACAAATGCAGTGAAGCTTGATGACACTTACATAAAAGCCTACTTGAGAAGAGCCAGTGTTACATGGACACAGAACAGTATGAAGAAGCATACGAGACTATGAAAAGTGTATCAGACGGAGAAAACAAAAGAACACAAACAGCTCCTAAAAAATGCACAGCTGGAACTGAAGAAGAGTAAGAGGAAAGATTACTACAAGATTCTGGGAGTGGACAAGAATGCCTCTGAGGACGAGATCAAGAAAGCTTATCGGAAACGGGCCTTGATGCACCATCCAGATCGGCATAGTGGAGCCAGTGCTGAGGTTCAGAAGGAGGAGGAGAAGAAGTTCAAGGAAGTTGGAGAGGCCTTTACTATCCTCTCTGATCCCAAGAAAAAAGACTCGCTATGACAGTGGACAGGACCTAGATGAGGAGGCATGAATATGGGTGATTTTGATCCAAACAATATCTTCAGGCTTTCTTCGGCGGTCCTGGAGCTTCAGCTTTGAAGCATCTGGTCCAGGGATTTCTTTTTTCAATTTGGCTAATGAAGGGCAACCACCCAGAACCCAGAAAATGCAGATTCACTCAGTTTAATCTTGAATGTGGAAACAGTTCACCTCCTCCCTTCATCACGTCTCCATGTACTTAGAGCAGTTTCGTTTTCTCAGTTGGATGCCCTGTGTCTCTGTGAGTGGGGTGGAGCAAAGGGAACCAATGCCGAAGACGCGGGCAGGGGAGGGAGGCGGGGGTGGACAGGGAGGCAGCTTGTGAATTTTTTGTTTTACTGTTTAACTTTATTAAAAAAGAAAAAAAAAAAAGAAGAGAATAAATGTTTTGACCCT 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@rCer/1012/25_2072_CCS ATGGGGGGAGGTGTTTAGGCGAAAGTGGGGGCTTTGGGTGTCGGGAGCCGGCTGACGGTGGACAAGGGGGGCTTAGCAGCTGGGCTGCGACCGTTAGCGAGGGGCTCAAGGTGTGCATGTGTGAGGAAGAGGGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCTCTCAGCCTGCGAGCCTTCTTCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGCGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCGTCACATGAGTTTGAGCACACTAAAAAAGACTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGATTCAACCTATAAAAGATAAAGGCCAGAGGCTTGCCTGATAATATATCTTCTGTGTTGAACAAATAGTGGTGGTGAAACTCAATGTGGTTTGGAACCAGCATGGGCTGCAAAGGCCTAAAAGTCTGATTGGTGTGAGGAATGAGAATACTTTTCTGGATCTGACTGTTCAGCAAATTGAACATTTGAATAAAACTACAATACAGAGTTCCTCTTGTTTAATGAACTCTTTAACACGGATGAAGATACCAAAAAATACTACAGAAGTACAATCATTGTCGTGTGAAAATCTACACTTTCAATCAAAGCAGGTACCCGAGGATTAATAAAGAATCTTTACTTTCCTGTAGCAAAGGACGGTCTTACTCAGGGAAAATACAGAAGCTTGGTACCCTCCAGGTCATGGTGATATTTACGCCAGTTTCTACAACTCTGTTTGCTTGATACTTTATAGGAGAAGGCAAAGAGTATATTTTTGTGTCTAACATAGATAATCTGGGTGCCACAGTGGATCTGTATATTCTTAATCATCTAATGAACCACCCAATGGAAACGCTGTGAATTTGTCATGGAAGTCACAAATAAAACACGTGCAGATGTAAGGCGGGACACTCACTCAATATGAAGGCAAACTGAGACTGGTGGAAATTGCTCAAGTGCAAAAGCACATGTTGACGAGTTCAAGTCTGTATCAAAGTTCAAAATATTTAACACAAACAACCTATGGATTTCTCTTGCAGCAGTTAAAAGACTGCAGGAGCAGAATGCCATTGACATGGAAATCATTGTGATCCAAAGACTTTGGATGGAGCCTGAATGTCATTCAGTTAGAAACTGCAGTAGGGCTGCCATCAAAAGTTTCGAGAATTCTCTAGGTATTAATGTGCCAAGGAGCCGTTTTCTGCTGTCAAAACCACATCAGATCTCTTACTGGTGATGTCAAACCTCTATAGTCTTAATGCAGGATCTCTGACAATGAGTGAAAAGCGGGAATTTCCTACAGTGCCTTGGTTAAATTAGGCAGTTCTTTTACAAAGGTTCAAGATTATCTAAGAAGATTTGAAAGTATACAGATATGCTTGAATTGGATCACCTCACAGTTTCAGGAGATGTGACATTTGGAAAAAATGTTTCATTAAGGGAACGGTTATCATCATTGCAATCATGGTGACAGAATTGACATCCCACTGGAGCAGTATTAGAGAACAAGATTGTATCTGGAAACCTTCGCATCTTGGACCACTGAAATGAAAAATACTGTGGACGCTTTGATAATGGGCTAGTTTCTTACAATGAAATGTTCTCTAGGATTCTAAAATAGGCAGGTACTTTACTATGTTACTGTACCCTGCAGTGTTGATTTTTAAAGTAGAGTTTTCTGCAGTATGCTTTTAGTCTAAGAAAAGCACAGATGGAGCAATACTTTCCTTCTTTGAAGAGGATCCCAAAAGTTAGTTCATCTTAAAGTGCAATATTGTTTAATCTTAAAACTGGGGCAACTCTGGAAGATCTTTAACAGAAGCCTCAGTGATGGTCACATTGAATTGCTTGTCATTTCAAAAATAAAGCAGTGAAGC 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rCer/1021/5977_59_CCS ATGGGACCCGACTCCTTTAGATTACTATGGATCGGTAAGGGTCCTGAGCGTTGGAGAAGCAGGAAAGCTTATCCTGGGAAGAAGGGCTTGGCTTGGATTTAGGAAAAGAATACTACATCGAGACCTGCTGGGGAATTTTATTTTATTTTATTATTATTATTATTTTGTCTGGTTGTACTGAGGGAGGAAGAGGAGGTTGTGTGGCCCGTCGACTTGTGGCAGCCTGAAGGCCCCTTCAGGCGGCGCCGCGGCAGCCCCGCAGCCGGGCCTGGTGCAGCCGCCGCGGCCGCTGTCAGGGAAGCGCAGGCGACCAATGGAACCCGGGAGCGGTCGCTGCTGCTGAGGCGGCGGTGTCGGCAGTCCGACCGCGACTGGCCCGCACCCCCTCCGCGGGGGTCCCCAGAGAGTTGGGTCCACACTCCAATGAGAATGCTGAAACACCATGCAAAGCAGCAAATTGAGATTCCTTGATTTGGGGAAGAGATTTGGGAGGAACCCTTCAATAATTGGCATGGGACAAGAGGGGACCCAGTCCAAGTGTATTTTGGGACCGCAGTAGGGAGGAACAATTCAGAGAAGAGCTTGGAAGCTCGAAGTCTGGCTGTGGCCATGGGAGAATACAGTAGTGGAGCCTGCCCCCTGAAGCCAACTTCTGAGCCCACTTCTGGCCCACCAGAGGAATAATGGGGGGTCCCTGCTAAGTGTCATCACGGAGGGGGTCGGGGAATTATCAGTGATTTGATCCTGAGGTGGCCCAGAAGGCTGCCAGGAGGTGTTGGAGAAGGTCAAGCTTTTGCGTGGAGGCGTGGCAGTCTCTAGCAGAGGCACCCCACTGGAGTTTGGTCAATGGGATGGTGTGGACAGTGAGATCCGTTGCTAGATGATCCACCTGCCCAGATCAGGGAGGAGGAAGATGAGATGGGGGCCACAGTGGCCTCAGGCACACCAAAGGAGCAAGAAGACGGCGGCAGAACAACTCAGCTAAACAGTCTTGGCTCCTGAGTCTGTTTGAGTCAAAACTGTTTGACATCTCCATGGCCATTTCATACCTGTATAACTCCAAGGAGCCTGGAGTACAAGCCTACATCGGCAACCGGCTCTTTCTGCTTTCGCAAATGAGGACGTGGACTTCTATCTACCCCAGTTGCTTAACATGTACAATCCACATGGATGAGGACGTGGGTGATGCCATTAAGCCCTACATAGTCCACCGTTGCCGCCAGAGCATTAACTTTTCCCTCCAGTGTGCCCTGTTGCTTGGGGCCTACTCTTCAGACATGCACATTTCCACTCAGCGACACTCCCGTGGGACCAAAGCTACGGAAGCTGATCCTTTCAGATGAGCTAAAGCCAGCTCACAGGAAGAGGGAGCTGCCTCCTTGAGCCCGGCCCCTGACACAGGGCTGTCTCCCTCCAAAAGGACTCACCAGCGCTCTAAGTCAGATGCACTGCCAGCATAAGTCTCAGCAGCAACTTGAAACGAACAGCCAGAACCCTAAAGTGGAGAATGAGGATGAGGCTCCCTACCTGATTTATGTGGAAGTCCTTGAATGTGAAAACTTTGACACACCAGTGTCCCTGCCCGAATCCCTGAGAACCGAATTCGGAGTACGAGGTCCGTAGAGAACTTGCCCGAATGTGGTATCACCCATGAGCAGCGAGCTGGCAGCTTCAGCACTGTGCCTAACTATGACAACGATGATGAGGCCTGGTCGGTGGATGACATAGGCGAGCTGCAGGTGGAGCTCCCCGAAGTGCACACCAACAGCTGTGACAACATCTCCCAGTTCTCTGTGGACAGCATCACTAGCCAGGAGAGCAAGGAGCCTGTGTTCATTGCAGCAGGGGACATCCGCCGGCGCCTTTCGGAACAGCTGGCTCATACCCGACAGCCTTCAAAACGAGACCCAGAAGATCCTTCTGCAGTTGCTCTCAAAGAGCCCTGGCAGGAGAAAGTACGGAGGATCAGAGAGGGCTCCCCCTATGGCCATCTCCCCAGTTGGCGGCTCCTGTCAGTCATTGTCAAGTGTGGGGATGACCTTCGGCAAGAGCTTCTGGCCTTTCAGGTGTTGAAGCAACGCAGTCCATTTGGGAACAGGAGCGAGTGCCCCTTTGGATCAAGCCATACAAGATTCTTGTGATTTCGGCTGATAGTGGCATGAATTGAACCAGTGGTCAACGCTGTGTCCATCCATCAGGTGAAGAAAACAGTCACAGCTCTCCTTGCTCGATTACTTTCTACAGGAGCATGGCAGTTACACCACTGAGGCATTCCTCAGTGCCCAGAGAAATTTTGTTGCAAAGTTGTGCTGGGTACTGCTTGGTCTGCTACCTGCTGCAAGTCAAGGACAGACACAATGGGAACATCCTTTTGGACGCCGAAGGCCACATCATCCACATCGACTTTTGGCTTCATCCTTCTTCCAGTCACCCCGAAAATCTGGGCTTTGAGACGTCAGCCTTTAAGCTGACCACAGAGTTTGTGGATGTGATGGGCGCCTGGATGGCGACATGTTCAACTACTATAAGATGCTGATGCTGCAAAGGGCTGATTGCCGCTCGGAAACACATGGACAAGGTGGTGCAGATCGTGGAGATCATGCAGCAAGGTTTCAGCTTCCTTGCTTCCATGCTCCAGCACCATTCTAAACCTCAAAGAGAGGTTCCACATGAGCATGACTTGAGGAGCAGCTGCAGCTGCTGGTGGAGCAGATGGTGGATGGCAGTATGCGGTCTATCACCACCAAAACTCTATGACGGCTTCCAGTACCTCACCAAACGGCATCATGTGACATGCTCCTCAGCCCAGGGAGTGCTGGCGGGGGGGTTCAGGGGCACCCTCCTAGAGGGGCCCTTGTCTTGAGAAACCCCAAACCAGGAAACCCACCTACCCAACCATCCACCAAAGGGAAATGGAAGGCAAGAAACACGAAGGATCATTGTGGTAACTGCGGGAGCTTGCCGGGGGGGTGGGAGAGCCAGCTTTGGGGTCCAGACTTGCTGGGGCTTCCTGCCCCTCCTGCTCTGTGTCAGTATACCACCGGACTAGCTCCAGATCACTGCCCTCCAAAAACAGAGGCGAATGAATGTGAGGGACGCCCGGGCCTTTCTTCTCCTTGTAGGGTTTTGAGAGTTTCTTTCCAACAGACCATTCCTCTTATTCCGTTTCTGGGGCCCAGGAAGTGGGAAGAGTAGGTCTCGGTACTTAGGACTTGATCTGTGGTTGGCCACTGGCCATGCTGCTGCCCAGCTCTACCCCTCCCAGGGACCGACCCGTGGCCCGAGCTCCCCTTGCTGGCGGGCGCTGCGTGGGCCCTGCACTTGCTGAGGTTCCCATTTATGGGCAAGGAAGGGAATTCCCACAGCCCTCCAGTGTTCTGAGGGTACTGGCCTAGCCATGGGGAATTCCCTACCCTGACTCCTTCCCCAAAACCCAGGAAAAGAGCTCTCCATTTTTTATTTTTTAATTTTTTGTTTGAAATAAAGAGTCCTTAGTTAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGATACTCTGCGTTGATACCACTGCAAGCAGTGGTATCAACGCAGAGTACAGGGGAGCAGAGAGGAGTTTGAGGGCGATGAGAGCGGGTACTGCGAACTGCGGGCGATGCTGTCGCTGCCGCCTTGATACGGAGAGCAACAGTTCCCCAGCCAACACCCCTCCCCGACACAGGCACACACCCCCCGACAGGCAACGCACACCCACCCCACAGTGCCCGGCTCGGCTGGCCCCCTCTATTGGCCCAGGAAGCCCACCCTGCCCCGCCACGCAGAGCCCAGAAGGAAAGAGAGCCTCATGCCTGAGCCGAGGGAGCACCATGGATCTGACAAAAATGGGCATGATCCAGCTGCAGAAACCCTAGCCACCCACGGGCGCTGTGCAAGGCCAACCAATGCGGCTGGCCGGGACTCTGTGCGATGTGGTCATCAATGGTGGACAGCCAGGAGTTCCACGCCCACCGGACGGTGCTGGCCTGCACCAGCAAGATGTTTTGAGATCCTCTTCCACCGCAACAGTCAGCACTATACTCTGGACTTCCTCTCGCCAAAGACCTTCCAGCAGATTCTGGAGTATGCATATACAGCCACGCTGCAAGCCAAGGCGGAGGACCTGGATGACCTCTTGTATGCTGCCGAGATCTGGAGATCGAGTACCTGGAGGAGCAGTGCCTGAAGATCCTGGAGACCATCCAGGCCTCAGACGACAATGACACGGAGGCACCATGGCCGACGGTGGGGCCGAGGAAGAAGAGGACCCGCAAGGCTCGGTACCTCAAGAACATCTTCATCTCAAAGCATTCCAGCGAGGAGAGTGGGTATGCCAGTGTGGCTGGACAGAGCCTCCCTGCGCCCATGGTGGACCAGAGCCCTTCAGTCTCACTCATTTGGTCTTTCAGCCATGAGTCCACCAAGGCTGCAGTGGACAGTTTGATGACCAATAGGACAGTCTCTCTGCAGGGAACTCTTCAGCCACCTGCAGGGCCCGAGGAGCCAACTCTGGCTGGGGGTGGCGGCACCCTGGGGTGGCTGAGGTGAAGACGGAGATGATGCAAGTGGATGAGGTGCCCAGCCAGGACAGCCCTGGGGCAGCTGAGTCCAGCATCTCAGGAGGATGGGGGACAAGTTGAGGAAAGAGGCAAAGAGGGCCTGGGACCCCACTCGAAGCAGCGTCATCACCAGTGCTAGGGAGCTGCACTATGGGCGAGAGGAGAGTGCCGAGCAGCTGCCACCCCAGCTGAGGCTGGCCAGGCCCCCACTGGCCGACCTGAGCACCCAGCACCCCGCCTGAGAAGATCTGGGCATCTACTCCGTGTTGCCCAACACAAGGCTGACGCTGTGTTGGCATGCATCTTTCGGTGACCTCTGGCCTCCACGTGCAGCCTGCCCTGGCTGTCTCCATGGACTTCAGCACCTATGGGGGGCTGCTGCCCCAGGCTTCATCCAGAGGGAGCTGTTCAGCAAGCTGGGGAGCTGGCTGTGGGCATGAAGTCAGAGAGCCGACCATCGGGGAGCAGTGCAGCGTGTGTGGGGGTCGAGCTGCCTGATAACGAGGCTGTGGAGCAGCACAGGAAGCTGCACAGTGGATGAAGACGTCGGGTGCGAGCTCTGCGGGAAGCGGTTCCTGGATAGTTTGCGGCTGAGAATGCACTTACTGGCTCATTCCAGCGGGTGCCAAGCCTTTGTCTGTGATCAGTGTGGTGCACAGTTTTCAAAGGAGGATGCCTGGAGACGCACAGGCAGACCATACTGGCACTGACATGGCCGTCTTTGTCTGCTGTGTGGGAAGCGCTTCCAGGCGCAGAGCGCACTGCAGCACAATGGAGGTCCACGCGGGCGTGCGCAGCTACATCTGCAGCGAGTGCAACCGCACCTTCCCCAGCCACACGGCCCTCAAACGCCACCTGCGCTCACATACAGGCGACCACCCTACGAGTGTTGAGTTCTGTGGCAGCTGCTTCCGGGATGAGAGCACACTCAAGAGCCACAAACGCATCCACACGGGTGAGAAACCCTATGAGTGCAATGGCTGTGGCAAGAAGTTCAGCCTCAAGCATCAGCTGGAGACGCACTATAGGGTTGCACACAGGTGAGAACCCTTTGAGTGTAAGCTGTGCCACCAGCGCTCCCGGGACTACTCGGCCATGATCAAGCACCTTGAGAACGCACAACGGCGCCTCGCCCTTACCAGTGCACATCTGCACAGAGTACTTGCCCCAGCTCTCCTCCATGCAGAAGCACATGAAAAGGGCCACAAGCCCGAGGAGATCCCGCCCGACTGGAGGATAGAGAAGACGTACCTCTACCTGTGCTACGTGTGAAGGGAGGCCCGCGGCGGGTGGAGCCGAGCGGAGCCAGGAAGAGAAGAGTTGGATCGAGATGAAGAAGACT 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@rCer/1022/0_306_CCS GCCGGCTCTTCTCACCAAAAAAACACTTAATTCCATTCCCTAACCTAGTAACCTCCAGATCCAAGGCTCTCCTCACCTCAGCTGAGCTCTCCTTTTGAAAGTGATTCAGGGACTACGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCTGAGTGAGGTTGCCCAGGGTGTTGTCCCCAGTGGGGGAAGCAGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTATTTATTGATTCAGGAAACAAACACAAAATTCTGAATAAAATGACTTGGAAAC + S$"%,),'+%'*+'%(%,--*%&*-,$&''&%(-%')&($((*'-)'''#($'+,.,),'#'#%+(,,+''),&,)'&$'((*+&%%%#%'+$#&&$&)'&'+&&+))#()++'),()(("#$"&(+')$)(('#'&,,(*&(,,(-,*(&&(&''/(*)+&$+*&#%)+0*+/'&++-./*(+)%))*'+.--&,,).$+(&2/-))0+$"&+.0*-#,2./+2250-03*552'%*/-10+-*625,+0+'625.)--24)30.,-).,-))-,,/'/,/-/,+0-/-(,,,)-,/,2(.*11( @rCer/1024/1794_60_CCS ATGGGGACTCGTACGCGTACCGTACCGCGCTCGTTAGTATTCCAGGCCGCCGTACACGGCGAGTACGGGCGGGGCCGGCCTTGGCTGCGTCCGGGCGTTCCAGTGCGTAGTTCCGCCATACCCATCTCCACGACCTCGGTCGAGCATGTTCACCAGGGCCCAGGTGAGACGGATTCTGCAGCGGGTGCCCGGAAGCAGCGACTTGGCATCTACCGGTTCCTGCCCTTCTTTTTTGTCCTGGGAGGAACGATGGAGTGGATCATGATTAAAGTGCGCGTAGGCCAGGAGACCTTCTATGATGTCTACCGTAGAAAAGCCTCAGAAAGACAGTATCAGAGAAGGCTGGAAGATGAATGAGACTGAACTTCAGCAGTCAATAAAGTCAATATGAATTTTTACTATTGGTTTCAGTGCCTTTTAAAATGTACTTTTCAGATCTCTTGTTCTGACACAGCTTGTCCTTGATCAGCTGCACAATATTCCAATAACTGTCTTTGCAAAGAATTTTTATAGTTCTGTCTCTGCTTGAGTACTTCCCAAGTCACTGCAGGACAACACTTGTGGGAAAATTATTTCCTCCTAAGACACTCACTCGATGAATCTAGTCCATGAAATATTTCTTAAAACAATTCAAGGATCAATCAGGATGCTTTTCAGTGAAGCCTGAATTGTTTTCGGCAACTTTGTTTTTAGGCAACTAATGATAACCTTATTTACTTTTTTGCAGAATTCAAATTAAATTATGGACACATTCTCTATTGCAAGATCATTTAAGCCAGGATAATTATGCAGGTTATATTTCTGCCAGCTACTAGACTATAAACTTTTTGCTAGGGTGGTGAAATTCCTGATTGACTACGCATTTCTCAATGAACAGAAATACGCGCCTCCCTCGCTTGGCTCCACTAAATTGCGAGGACTGGACCTTCATGAGGACTCTGGGCAACAGGTTTATGCTACTCTATGATGAGATGCTGCTCTTCCATTCAGCTGCTAGAAACAGTTGCTCCTTCCATGAGAAAGTGAACCTACACAGCATAAGGCAATCCCAGACTTGAGCTAAATCAGAGGCTCAGTCTGTTGAGTGATTTGGCAATTTGACCCAGTGTAACTTTGGATCAGCCTGGTAGAAAAAGCAGACACCTTTCCATGCTTGCGTAACCACATCTAACATCATTTCAAGCAAGAAAATATCTACATACTAAAGACTAAGTTTCAGAATAGTTTCTAAACTATTGCACGAGAATAAAGCTGATGCTTAAGGCCACAGGGTATCAAGTTAATGATCTCTGCCATAAACATATCTCCTAATTTTTTCTAGAGATTTTTCTCCTAATTTTAGTCCACTTATGTTAGAACCAATTCAGTAAAGAAGAACCATTAACTACTCACATCTCATTAAAGCACTACCTACACTACAGTACAGCAAGCCCAGAGTCACAGCTGGGAGATGGCTTGAATGTGAAAGGCCAGTAATGACCTCTACTACCAGGGAGAGGACGGTGGTTCATCATATTCTCATGCCCAGTTGTGTCATCTAGGATTCCTGGTAAACCTAACCTGATAAACCATTTTTAGTGACTTGACTGCTGTATAAAAAGTATAGTATGATTCTCTCAATTATATGGCCATATTCCATGTTTGCCCTAATCCACCTTGTTTTAGGAGTTGGTACATATAGAAAATATATCATACCTTTTACAAAGAATAACAGTAAACACTAATAAAACCATT 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@rCer/1025/1803_52_CCS ATGGGGGCCCCTTGGACTGGAAATGCGATTCTGAGATATTCGGATGCTGGGAGCTGGAGGCGGAGGCGGCTGGGGAGGTCGAGCGATGTGACCAGGCCGCCATCGCTCGTCTGTTCTTCTCTCCTGCCGCCTCTGTCTCGAAAAATAACTTTTTTAGTCTAAAGAAAGAAAAAAAAAGTAAGCCGTCCGCCCTCACGCCCTCTCTTCCTCTCAGCTTCTGCCCGGTGAGGAAGCCCGGGGTGGCCGCTCCGCGTCGGGCCGCGCCGCCGAGCCCCGGCCGCCCCGGCCGTCCCCGCACGCCGCCCCCATGCATCCCTTCTACACCGGGCCGCCACCATGATAGGCGAGATCGCCGCCGCCGTGTCCTTCATCTCAAGTTCCTCCGTACCAAGGGGCTCACGAGCGAGCGACAGCTGCAGACCTTCAGCCAGAGCCTGCAGGAGCTGCTGGCAGAACATTATAAACATCACTGGTTCCCAGAAAAGCCATGCAAGGGATCGGGTTACCGTTGTATTCGCATCAACCATAAAATGGATCCTCTGATTGGACAGGCAGCACAGCGGATTGGACTGAGCAGTCAGGAGCTGTTCAGCTTCTCCCAAGTGAACTCACACTCTGGTTGACCCCTACGAAGTGTCCTACAGAATTGGAGAGGATGGCTCCATCTGTGTGCTGTATGAAGCCTCAACCAGCAGGAGGTAGCATCAAAACAGCACCAACGTGCAAATGGTAGACAGCCGAATCAGCTGTAAGGAGGAACTTCTCTTGGACAGAACGAGCCCTTCCAAAAACTACAATATGATGACTGTATCAGGTTAAGATATAGTCTGTGGATGGATCATCTTATAATGATGGATAAATTTTGATTTTTGCTTTGGGGGCTCCTCTTGGGGATGGATTATGGAATTTAAACCATGTCACAGCTGTGAAGATCTGGCACAAGATAGAATGGTAAAAAAAAATTTTTTAAGTGACAGTGCCATAGTTTGGACAGTACCTTTCAATGATTAATTTTAATAGCCTGTGAGTCCAAGTAAATGATCACTTTATTTGCTAGGGAGGGAAGTCCTAGGGTGGTTTCAGTTTCTCCCAGACATACCTGAATTTTTTACATCAGTCCCTTTAAAGAAAATCTGTATTCAAAGAACCTTTCTCTGCAGTAAATCTCGCAGAGGAATTTGCACTATTACACTTGAAAATTGTTACTGTTAACCTTTTTGCAGCTCAAATAGGAAAGCTGAACGTTTTAAACATGGTAGTACTGGAAATTTTACAAGACTTTTACTAGCACTTATGTATAAATGTACATAAAGACAAACTAGTAAGCATGACCTGGGGAAATGGTCAGACCTTGTATTGTGTTTTTGGCCTTGAAAAGTAGCAAGTGACCAGAATCTGCCATGGCAACAGGCTTTAAAAAAGACCCTTAAAAAAGACACTGTCTCAACTGTGGTGGTAGCACCAGCCAGCTCTCTGTACATTTGCTAGCTTGTAGTTTTCTAAGACTGAGTAAACTTCTTATTTTTAGAAGTGGAGGTCTGGTTTTAACTTCCTTGTACTTAATTGGGTAAAAGTCTTTCCACAAAACCACCATCTATTTTGTGAACTTTGTTAGTCATCTTTTATTTGGTAAATTATGAACTGGTGTAAATTTGTACAGTTCATGTATATTGATTGTGGCAAAGTTGTACAGATTTCTATATTTTGGATGAGAAATTTTCTTCTCTCTATAATAAAGTTTTTCTATCTTG 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@rCer/1028/25_2530_CCS ATGGGCCCGCGGCCGGCGCGGGCGGTGGTAGCGCCTCAGTGGTGAGGGCCTGCGTCCTGCCCAGGTGCCCCAGAGAGCAGCCGGGCCGCCCGCGTTTCATGATCAACATGGGGGACTCCCACGTGGACACCAGCTCCACCGTGTCCGAGGCGGTGGCCGAAGAAGTATCTCTTTTCAGCATGACGGACGTGATTCTGTTTTCAGTCATCGTGGGCCTCCTAACCTACTGGTTCCTCTTTAGAAAGAAAAAAGAGGAAGTCCCTGAGTTCACCAAAATTCAGACATTGACCAGCTCTGTCAGAGAGAGCAGCTTCGTGGAAAAGATGAAGAAAACGGGGAGGAACATCATCGTGTTCTACGGCTCCCAGACGGGGACTGCAGAGGAGTTTGCCAACCGCCTGTCCAAGGACGCCCACCGCTATGGGATGCGAGGCATGTCAGCGGACCCCGAGGAGTATGACTTGGCGGACCTGAGCAGCCTGCCGGAGATCGACAACGCCCTGGTGGTTTTCTGCATGGCCACCTACGGCGAGGGGGACCCCACCGACAATGCCCAGGACTTCTACGACTGGCTCCAGGAGACGGACGTGGATCTCTCTGGGGTCAAGTTTGCGGTGTTTGGTCTTGGGAACAAAACCTACGAGCACTTCAATGCCATGGGCAAGTACGTGGACAAGCGGCTGGAGCAGCTCGGCGCCCAGCGCATCTTTGAGCTGGGCTTGGGCGACGACGATGGGAACTTGGAGGAGGACTTCATCACCTGGCGAGAGCAGTTCTGGCCGGCCGTGTGCGAGCACTTTGGGGTGGAAGCCACTGGCGAGGAGTCCAGCATTCGCCAGTACGAGCTTGTGGTCCACACTGACATAGACGCGGCCAAGGTGTACGTGGGGAGATGGGCCGGCTGAAGAGCTACGAGAACCAGAAGCCCCCGTTTGATGCCAAGAATCCATTCCTGGCTGCAGTCACCACCAACCGGAAGCTGAACCAGGGGACCGAGCGCCACCTCATGCACCTGGAATTGGACATCTCGGACTCCAAAATCAGGTATGAATCTGGGGACCACGTGGCTGTGTACCCGGCCAACGACTCTGCCCTCGTCAATCAGCTGGGCAAAATCCTGGGTGCCGACCTGGATGTCGTCATGTCCCTGAACAACCTGGATGAGGAGTCCAACAAGAAGCACCCATTCCCGTGCCCCACGTCCTACCGCACCGCCCTCACCTACTACCTGGACATCACCAACCCTCCGCGCACCAACGTGCTGTACGAGCTGGCGCAGTACGCCTCGGAGCCCTCGGAGCAGGAGCTGCTGCGCAAGATGGCCTCCTCCTCCGGCGAGGGCAAGGAGCTGTACCTGAGCTGGGTGGTGGAGGCCCGGAGGCACATCCTGGCCATCCTGCAGGACTGCCCGTCCTTGCGGCCCCCCATTGACCACCTGTGTGAGCTGCTGCCGCGCCTGCAGGCCCGCTACTACTCCATCGCCTCATCCTCCAAGGTCCATCCCAACTCTGTACACATCTGTGCGGTGGTTGTGGAGTACGAGACCAAGGCCGGCCGCATCAACAAGGGCGTGGCCACTAACTGGCTGCGGGCCAAGGAGCCTGCTGGGGAGAACGGCGGCCGCGCGCTGGTGCCCATGTTCGTGCGCAAGTCCCAGTTCCGCCTGCCCTTCAAGGCCACCACGCCTGTCATCATGGTGGGCCCCGGCACTGGGGTGGCCCCCTTCATAGGCTTCATCCAGGAGCGGGCCTGGCTGCGACAGCAGGGCAAGGAGGTGGGGGAGACGCTGCTGTACTACGGCTGCCGCCGCTCGGATGAGGACTACCTGTACCGGGAGGAGCTGGCGCAGTTCCACAGGGACGGCGCGCTCACCCAGCTCAACGTGGCCTTCTCCCGGGAGCAGTCCCACAAGGTCTACGTCCAGCACCTGCTAAAGCGGGACCGAGAGCACCTGTGGAAGCTGATCGAAGGCGGCGCCCACATCTATGTCTGTGGGGATGCACGGAACATGGCCAGGGACGTGCAGAACACCTTCTATGACATCGTGGCTGAGCTCGGGGCCATGGAGCACGCCCAGGCCGTGGACTATGTCAAGAAGCTGATGACCAAGGGCCGCTACTCCCTGGACGTGTGGAGCTAGGGCCTCGCCTGCCCCGCCCACCCCGCAGACTCCTGCCTGTAATCACTCTCCTGGCTCCCTCCTGCAGTCTCCTGGCGGGTTTGGCTTGGCCTTGGCACAGGCGCAGGTCCAGTGACAGAGACTCCTCCGGGGCCTGAGGTGCACCCTCCTGAGCTCCCCAGGCCAGGTGAGGGCCTCCGGCAGCACAGCCCAGGGCCTGCACGGGGGCACCGGGCTCCATGCCTTGGGAGGCCTCTGGCCCCTTGGTGGCCACACAGAAGGGCTCTTTCTCTCAGCTGAGCTGGGCCCAGCCCCTCCATGTGATTTCCAATGAGTGTAAATAATTTTAAATAACCTCTGGCCCTTGGAATAAAGTTCTGTTTTCT + @D6B>'BB>D=DDGABAEEC<4CCC@<+C2GFEEC9C;AFFAEBAC;C?8?;C;EEFFA1D>B@4BAD<:ECEEECBEAGG3CC@AAA4EB?.CDD>D@B:DB?EBAEGBE??F@DDDCBG;<>4<@=1FB7ECA@EGG8D;EDD@D@GD:5DFF@C;BBC<@AAEF@G6C=1DEFEC=@CE><=;D5F:FCBFC;DEE>CD@DECCCCGGGFBD(5B@C;AB@G7?DADFEB+C?DA@0CEA:AECFA@CCE:GA?=A7@?CC:?C>AF<0E@A;EFCEB@DF>F?BGFDGA@BDEA=>=EBEBA@B@:AFD==C=;'>=8E:C3B6GE>FE>FFD@G>ACBAFGGF@CF8DAEDC7>4AE?8BCFBFD:7EB6?FEF>@?9:E:C>D@=BFDGEE*A;8CED>?CF;?B4@@EF0FFBEG,FFE?DAD;BDD@BEG>EB@EBGD7EB:GFC;D??E<7=B?BDF>BA@A<:=1E;1?F3E8C;E=?=7BCEBDFFA7EB>BD?FE@?6?6>?A@>DE@9>@@AGE9A7E>;@>@B@<>@CB@3D@7@>E?:=?B=AAA23764>=D1@?4ACDCA3=C:7B9?A+?03;A@A@=;73=>@CBAC@FF?5@FDG?G5A2=<;E?93?FDB816<8BBC>>E;@C:?EABDCA0EAC?9@3A>CBFA/7CFEC3EDD5DEFBCGD;F?CCCGEF8FB?FAAAABC9>C?DC*C=9<4AB=B;@B:BDCF>C>7EB<9:AF@5=->>;;>27:9BEBB=CE@2BACB6<@=BC:ADFEFC;F>D2FF97CBCBA8=?7>;?>7<;A==@@>@@6;CB>AEFC7EC7A@A?ACACGB@7:=<9><0?=@@:A>?;@<:&:6B@=F9BC8.A0<;<>:FAAA6DDC*@=F9>CCFDBA?BC>+A;:;CFDF=9@4B84DE:ECBCBC?F?B=3==:1?AAC@AD6>@@@ED8DEAGCECF@E@?B>E8D37FEDCHBFHAHAHEAAHDF=DHDC7HEH4C=A>HGJEIEGFEI;EIEH?EIIIIIHI>BFAFJF@GD;FHEJI?J9FGGIIAD5CI>E3>@C>@2BC?A?FHD:FH38FFDG7F@FHCFFE;FFDHHFJFFDA6>F7EA:GAG0D@GB>GHJA2CE2GCGDICAIC;HHED>D&FDGD@IHDDHGF8;HCIE9HC=EIHIBJHFBIIABJGD=>9HGI?=EE9JFD6DBGDB8I@DEEIBFEG@HIBJIFIEACCHFGEEFC?D2BG@HIHIIHIHEJH@EBG3B@>==BBEADHDFC;GGIEH7BIBG:FDEBJCAB@IG@>AFIG;G;HDGHB7FGI?HAEHEICF&@BFHC2EA@HIHG;9;3GHJDDBG?EEHAIHFBHCGJA7ECED@CEC;AFG=@=B;E@B@AEB>AEDCC@E>2@@EC@B(?DDDEEB/E;CFBDBCFEA8GBGF?CDA.6A/>6@D;B5@C4>@;B?>:EDBBCFCBE>BCBE:GD;EE@A=E:C0BGFBCG>D@E@@@+@;EGABCBC>A?FEE:FEDECEBD>B<<>@C;%A?EGD?E@>DB)E39BB8F)@CBEAEGGAFCADA?FFFC@ACED=;;A>??=:<5BEC8@@EE@EC?=?>?AB:BBEA:>27>EDA>?;FC<9BDDCBBGECE@AD:BF;DCD?G9DDD;DEE=F:EEAEBECGG9D3?4E@BBG?=EDDE=BFDDB @rCer/1029/772_57_CCS AGCTTGTGCCAGACAGCAACAGCACACAGTTGAAAACGCCCCAAGTATCACCAATGCCCAGAATCAGTCCCTCCCAGTCGGATGAGAGAAGAGACCTATCAATGCATCAAGTGTCAGATGGTTTTCTACAATGAATTGGGATTTTCAGGTTCATGTTGCAAATCACATGATTGATGAAGGACTGAACCATGAATGCAAACTCTGCAGCCAGACCTTTGACTCTCCTGCCAAACTCCAGTGCCACCTGATAGAGCACAGCTTCGAAGGGATGGAGGCACCTTCAAGTGTCCAGTCTGCTTTACAGTATTTGTTCAAGCAAACAAGTTGCAGCAGCATATTTTCTCTGCCCATGGACAAGAAGACAAGATCTATGACTGTACACAATGTCCACAGAAGTTTTTTCTTCCAAACAGAGCTGCAGAATCATACAATGACCCAACACAGCAGTTTAGTGCAAGTACAGTCTCTCAAGAGAATTGCTTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACATTGTATTGTACCATAAAACTTGTATTATCAAAACTGTTGGATGTTCATGTGTTGAACTTTTGCGCACAGATAGACCCCTTGTATATAAAGTGTTGCACTGTATTATGTCGTCTGATACTAAAATGGTCTTATAAAGACAAGTGGACTTGGGCCCTATTC + (,,&'+),-',,&(+,)*#))--((,-)(,),,--)-+'*,).*-+()*)$"&$%+,.+--)&&'+*%)*&(+,),),+(&$,)&'$&&#($()+(&('*&')(,,)**%,,+),-+(&(&-.-&&+),.+-,,###--)-...+--.+,&,*---),'*-+*--+(()--+&,*(-')$(++*--.)'+120,*++++(1/,11112-0-1200..00011121.120200/,'+,--+0,)0011/*&/.,10,-/-//-,*)&$#&#'%&'#',(*-./-%+/+(+%$'''$,,+*%,+(+*&./'*2,,-(&'+/''*(%++,(()-*,2)1.+02$+-,-13-'*+/-*')%#/)/)01-)+.*,,--'+*-,/*)).++),1++4124--44430%(1'0,33)(&%))-0,(-+'%''#%+-2(''%-)(+'/30./5.'34$20/+343134101221,+-+(*+(/)0-2..0.),,2-))-,,43))+&+$(+/,00.%2*.--/&0.-&010'++1'&-3+-5-3,++(%,+302-1/102.$324.0-42,0)-41-134-'322.*05/.'.00/)0+-1+.+**&2(*.%&*$2$.0%/2.1)*0,+%%')'**/)*+)$')-+-,,0,.'0112*($)"&%)&0(+*,,*.'%*(1/11/-/)%*+&'*(),(++#'.01*.,--,(,).*%11,*%)'( @rCer/1030/1756_60_CCS ATGGGGGGAGAGAGCGGGTGTTTGAAGGCTCCGCGGACCGGCACTAGGAGCCGGGGGCGGGTCCGTGACCCTCCGGCTTCTCGGAGCGAACAGGCGGCCAGGAAGAAGCGGGCCTGAACACCATGATCCCTCTGGAGAAGCCGGGCAGCGGCAGCTCCTCCCCAGCCGCCACCTCAGGCTCGGGCCGGGCCGGCCGGGGTCTGAGCGTGCCGTGCCGGCCGCCGCCGCCGCCACAGGCCCGCGGGCTGCTGACAGAGATCCGCGCCGCGGTGCGCACCGAGCCCTTCCAGGACAGCTACAGCCTGTGCCCGGGCCGGGAGCTGGGCAGGGGGAAATTTGCAGTGGTGAGGAAATGTATAAAGAAAGATTCTGGGATAGAATTTGCTGCAAAGTTCATGAGAAAAAGAAGAAAAGGCCAAGATTGTCGGATGGAAATAATTCATGAAATTGCTGTACTTGAACTAGCACAGGACAATCCTTGGGTCATTAATTTACATGAAGTTTATGAGACTGCATCAGAAATGATCTTAGTTCTGGAATATGCTGCTGGGGGTGAAATCTTTGACCAGTGTGTTGCAGACAGAGAGGAAGCCTTTAAAGAAAAAGATGTTCAGAGACTTATGCGACAGATTCTAGAAGGTGTTCACTTTTTACACACTCATGATGTAGTTCATCTTGATTTGAAGCCTCAGAATATTCTGTTGACAAGCGAATCTCCATTGGGTGACATTAAGATTGTTGATTTTGGCCTTTCAAGAATATTGAAGAACAGTGAAGAGCTCCGAGAAATTATGGGTACCCCTGAATATGTGGCTCCTGAAATTCTTAGTTACGATCCTATAAGCATGGCAACAGATATGTGGAGCATTGGAGTGTTAACATATGTCATGCTTACAGGAATATCGCCTTTCTTAGGCAATGATAAACAAGAAACATTCTTAAACATCTCACAGATGAATTTAAGTTATTCTGAGGAAGAATTTGATGTTTTGTCTGAGTCAGCTTATGACTTCATCAGGACACTTTTAGTTAAGAAACCTGAGGATCGAGCCACTGCTGAAGAATGTCTAAAGCACCCCTGGTTGACACAGAGCAGTATTCAAGAGCCTTCTTTCAGAATGGAAAAGGCACTAGAAGAAGCAAATGCCCTCCAAGAAGGTCATTCTGTGCCTGAAATTAATTCAGATACTGACAAATCAGAAACCGAGGAATCCATTGTAACTGAGGAGTTAATTGTAGTTACTTCATATACTCTAGGACAGTGCAGACAGTCTGAAAAAGAGAAAATGGAGCAAAGGCCATTTCCAAACGATTTAAATTTGAGGAACCTTTGCTACAAGAAATTCCAGGAGAATTTATCTACTGAGCAGTATTTCCTTTAGAACTTTAAGATTTCTACATTGAAAATGTTAATATTATTTATGGACCTCTGGCCAAATGGTACATGTACTGGAAGTGGATAACCAGTATCACTTACACAAACAAAAATAACTTTGTCAAATTTGTGGAGTTAGGTGGAAGTCACATTTTAAAAGTTGCCAACCAGGAGATTTAACAGGTACAGTTATCCATTTCAATGTTATTTTTAAGGGAGATGTTGGTACCTTGTAATTCTACACCCTGTTTCTCCAGAATGAGAATTTGTGTACAAAGATATTTGTATTCACTTTCTTTAAAAAATCCAAGTAAAAGTGCC + FKKKKKJ1GGKJKKKKKKEKKKCKKHKFKKKKKKKHKKKKJKKKKKK=HKKKKKKK.KKKJJIFKKKJKKCCKKKJKKKKDJJ1HKKKKEKKKHKKGKAHK?K%HKJIKKK+H?JKKEKKKIKGKJKKK8IBJKEIKKKDKIKKGKJKKJJKJKKKKGKKKK?EGKGKKJJK:KKKK@KKKKK3J:KK8H;I?J9KJI&IKBKHFKKHKKKKGIK?KFKF@KJKHKKKAKK@KKKKGKGBKJKD=AFKKKJKIEJHKJKDFEB9I?BJKKIJKJKFKHJKKKK0KJK@KKJJKHKHE8JKKKGGKJKKKDKKAK=KKFDJ=KKKKEKKKIJ7KKBKKIKJK:KCKFJ@KKK=KEIK*DFKEJJAHKEKCKIGKKKCK=JHE4JKKKKKKJKGKJKKKIKGFKK8IK;KCKKJIKGK@KBKK9IIKIHI>E@D0@5H3GAJKKKJKJJEKJFCFHCKKHKKKAKIKCKKKKKJKHJKHIKKK6HCKKGJKJJ8HKH@ICIIJHI1KJIKKKKKCIIK7KJGKKKJ5KKDKIKKK3JHJJKHKKKJ@KJKEGD?KI:KKKKK@JIHKKIE;>GKAHAKKKKK9DJFFJHJKIIKJJHJIKJ?JJ:AKBJJKK@IKHKKJHKJKK9F;G4KHKKH@KKKCJKJK:GKHB8?K=@G2FCIKJJ:KJIJKI@J7IHKKKCKEKKKKHHKHIJCIGKAFJ@KKCKKKIKKJIJJJBKAJKIKK>KCKGKK3IJHEH%JIJC7IFIEKIKIKECJFK;KEGK@HKKDKJJH>JGIIKKGKKKGKJKKIJKKKKJDJKKGDKJKKCKJFHGJKIKCHJIKKHGKJBJKKGEKHKKKJKKIHKKIKKFKKJKKGEKIKKEGHK@KK:IDK>KJKKKKIKKFJKIKKKIICJIJFK>DK:KJJH0HKEJKKJFIJFKHDKI@GJKKKKKGKKKKIKEFFCGHA@J?KK>GKKK=KKKBJKJKKIKKK:KIKKKGCDKGKKFKKKKIKJKKCKJKKFKKAK:KJKKIKJKEFK?CKKKCK3GFKGKJFIJIJDKKKKKHJJJJJK;KFFHK@HCAKJJKGKKKFIIKKKKJGKGK>KIKEFKK=HHI1JKKAJKKIKKJK=KJEJKKKAHKKJKKJKKKJKK/KHFKKK=CH9JKKJH#8?KGFJK0IHKKEKJJKK6,47*:9=<6:68868:(545>>6=868:1:0.;:>>9=3;+4?8:.;;+<;6<124>96<=0/9477;;;?<6<>9078:07137(969=767*=;516>>>=?8>.>>41>=9?=87==:===?3;:9<><7:92>:)7:>==>>:9=>99;:<97=:>=<::6>?>>24<=9:3==7<37591454%5:=:32<=6696=4>=9/3;,<:>=>>=9>6;?;=<=>817864=>=3<:)4<5=;>>=6==79><76??<:96<877*937;=?;/<<<=1:;8-;7+=12:>>>>=5;5<;:>7? @rCer/1033/25_1659_CCS ATGGGGTGTGCAAACCACGTTATTACTAAAACAATGGAATTAAAGCCCTTAAATGTTTCAAATAATGCTTTAGTTTGGACTGCCTCAGATTATGCTGATGGAGAAGCAAAAGTAGAACAGCTTGCAGTGAGATTTAAAACTAAAGAAGTAGCTGATTGTTTCAAGAAAACATTTGAAGAATGTCAGCAGAATTTATTGCAACTCCAGAAAGGACATGCAGCAGAATTATCAAAGGAGACCAATCCTGTGGTGTTTTTTGATGTTTGTGCGGACGGTGAACCTCTAGGGCGGATAACTATGGAGTTATTTTCGAACATTGTTCCTCGGACTGCTGAGAACTTCAGAGCACTATGCACTGGAGAGAAAGGCTTTGGTTTCAAGAATTCCATTTTTCACAGAGTAATTCCGGATTTTGTTTGCCAAGGAGGAGATATCACCAAACATGATGGAACAGGCGGACAGTCCATTTATGGAGATAAATTTGAAGATGAAAATTTTGATGTGAAACATACTGGTCCTGGTTTACTATCCATGGCCAATCGAGGCCAGAATACCAATAATTCTCAATTTTTTATAACACTGAAAAAAGCAGAACATTTGGACTTTAAGCATGTAGTATTTGGGTTTGTTAAGGATGGCATGGATACTGTGAAAAAGATTGAATCATTTGGTTCTCCCAAAGGGTCTGTTTGTCGAAGAATAACTATCACAGAATGTGGACAGATATAAAATCATTGTGTTTCATAGAAAATTTTATCTGTATAAGCAGTTGAGTTGAAGCTTAGTTATTACAATTTGATAATTATGTTCAGCTTTTGAAAATGGACGTTTCTGATGTACAGATGTAAAATTGCAGCTTATAGCTGTTGTCACTTTTTAATGTTATAATTGACCTTGCATGGTGTGAAATAAAAGTTTAAACACTGGTGTATTTCAGGTGTACTTGTGTTTATGTACTCCTGACATATTTGTATTAAAATGGAATAATACTAATCTTGTTAAAAGCAATAGACCTTCTCAAACTATTGAAGGAATATGATATATGCAATTTAATTTTAATTCCTTTTAAGATATTTGGACTTCCTGCATGGATATACTTACCATTTGAATAAAGGGACACAACTTGGATAATTTTACTTTAGATTTGAAATATATTTGGTAATCTTAACTATTGGTGTACTCATTTATGCATAGAGACTCATTTATGAATGGGTAGAGCCACAGAACGTACAGAGTTAACCAAAGTGCTCTTCTCTAGAATCTTTACACCTCCTGTGTGGTTACAAGTTAACTTTGTAAGTAGTGTACCTTCCTTCCTTAAAATATCTAGCTTCCTGTGCTCTTTCATAGGTATTCAATTAATTTTTACATTTTAAACAAGTTGACTATTTCCTTTAGGGTTTTGTTTTAAACTTTTCTGTCATCTGTCTCTACTACCTCAGAAACTGCAGCTTGGTTCTGATGATAGAAATGAATTTTTCCTTGTAGTTACTGTGATAAAGTATGAATATTTTTAGAAAGTCTATGCCATGTTACTTGGTTAAAGATTTGCTTTATACAGGATTGTTGCAGTACCCTTTTCTGGTAAATTTTGTAGCAGAAATAAAATGACAATTCATAAGAGCCACTGACAT + 5(%30-.5.41-644664.$.11556/&222356-*00656046535554+55450660-55556404*5400,5+'12142(555355.5,.5364651640064636635055252/5..530022156626646563314501350,341.31656264131*03320-26505506-53+3351536-660*2.4/650,314052-420-'-,34234(236350+2104+0234*20.23322650$/124325.3(530-*424.5-52536/55-34164/46/,-34564.650125+41,*-.333565%5..465541552-04356/240/155535.2').$/-(4-35/(34-4+'02/5.46014314.1261+5355344640601555115642535546655-5615024141/2565/5*312.4440164663562*55210/35515456662666263'3445614/5.550$.03362613&4.45100316525465/66544*124./061/)45541/2%12//1121536654143,0/4)4331%++*046652+464665115/451*43+554+66163550132113020/25.034.5*316/.462)4365.5651/+&5451/-.5455.2//14+233/3152+55045.35/-525546+6.,45.636660635624',%)603035154&32015/0105/+4455)/20145+644/043+/-*363652+5*/0*45262503/0.52,335*5-5625.56261-1-42135.666516662-5246-66244,-3/,0466645+545364100-466654150-121542%223.,344*23306462.-21664513666/4.64456533'3313622555511/0'122146633.5.154/&12..34356233052646564645-3'332/264661553436445133-2*554450520-3,3-3333-3243.05526153612*/14205.3015%0135'33206*3564666213022/3416401511-/00-*30*.'1.06,)/04654+51035(50-$/0/5516&0/3'3'540300410///445-541+10*46565561426&0510*5035/*/463515512*3//*50545564-441.-045/632554).31.10-435002-11/26/1-4,66312.*-,1565450*54/*44355060/515030+4)144+2.+0.43-662+-342144624163612565616*552+3/3552416*443424653666514,420.54/2*0)3*3554545*550+932+-23638725/2.'5,45.%87,8952%485&150$6565540644/5.757.749954:3:77'4473.28:8/989.66*78:7:728-77#0'0%18764:5::9:8*61457285559:644478938(6726864;8:672-.,480954;9937672817675/7:9:1::65:9<4=99?0*736>9-71::'797:27>4=<>5>;13=>>28<=3<5?5=7;=>>=<=;><75572 @rCer/1035/25_1554_CCS ATGGGGCGGCGCCGAGTGCACTGAAGATGGCGCTGCTGTAGGAAGGTTGCTCCGAGCGTCGGTTACCCGACATGTGAGTGCCATTCCTTGGGCATTTCTGCCACTGCAGCCCTCAGGCCTGCTGCATGTAGAAGAACGAGCTTGACAAACTTACTGTGTTCTGGTTCCAGTCAAGCAAAATTATTCAGCACCAGTTCCTCATACCACGCACCTGCTGTCACCAGCATGCGCCCTATTTTAAGGGTACAGCCGTTGTCAATGGAGAGTTCAAAGACTAAGCCTTGATGACTTTAAGGGGAAATATTTGGTGCTTTTCTTCTATCCTTTGGATTTCACTTTGTGTGTCCTACAGAAATTGTTGCTTTTAGTGACAAAGCTAACGAATTTCACGACGTGAACTGTGAAGTTGTTGCAGTCTCAGTGGATTCCACTTTAGCCATCTTGCCTGGATAAATACGCCAAGAAAGAATGGTGGTTTGGGCCACATGAACATCGCACTCTTGTCAGATTTAACTAAGCAAATTTCCCGAGACTACGGTGTGCTGTTAGAAGGTCCTGGTCTTGCACTAAGAGGTCTCTTCATAATTGACCCAATGGAGTCATCAAGCACTTGAGCGTCAATGATCTCCAGTGGCCGAAGCGTGGAAGAAACCCTCCGCTTGGTGAAGGCGTTCCAGTATGTAGAAACCCATGGAGAAGTCTGCCAGCGGACTGGACACCGGATTCTCCTACGATCAAGCCAATCCAGCTGTTCCAAAGAGTACTTTCAGAAGGTAAATCAGTAGATCGCCCATGTGTATCTGCACCTTCTCACCCCAGAGAAGAACCACAGTTGAAACCTGCTTTTATCATTTTAAAGATGGTTATTTGTAGAAGCAAGGAACCAATTATGCTTGTATTCATAAATATTACTCTAAATGTTTGTTTTTGTGATTCTGGCTAAGACCTTTTAAACATGATAGTTGCTAGTACAAGGAATCCTTTATTGGTAACGTCTTGGTGGCTAGCTAGCTAGTTTCTACAGAACATAATTTGCCTATATTGAAAGCGATTCTTAGATCATGTCTTCAGTGGAAACAGTCTTCTGTCTTAGCCTTACTTGAATCTTGCCTATAACAAAGTAGAGCAACATGCATTGAAAGCGTCTGATCAAGGGTCCTGAAATTTTCAATTTGAATGTCTTTGTATTAAACTGAATTTTCTTTTAAGCTAACAAAGATCACTATTTTCAATTAGCCGTCTAACTCTTGCAATGAATGTTTATGTGATTGAAGCAAATGTGAATCATATTATTTTAAAAGTGGCAGAGTGACTTAACTGATCATGCATGATCCTCATCCCTGAAATTGATAGTTTATGTAGTCATTCTACTTATTTTATTCACTAGCTAACTTTGTCTATGTATATTTCTAGATATTGATTACTGTAATTGATTATAAAGGATATTTATTAACTTCAGGATTGCATTTTGAAATTACAATTATTTTCTTTGCTGAAGTATTCATTGTAAACATAAAATAAACATATTT + HH6KGFH?69KGGH9KK;K5G>J.KKKH'KFHKKKKJKCKKKHJH%CDKC5I?KKJJKJK4KKDK)KKE;KBHG*DK+KKKK-KKK(HKJIKK9KCKK8KJ(JKJI2;KKKKKKEKJKKKKJJBKK;KKFKKKJ'KAK3'KK%KKI&HKDJKJKIKJK&KIKKKJKKKKKIKJH@.KK5KKKK*KED5KJKCHJ&KJCK3KKJJBKE=K1KBKJ;K3G5KEJKHJKI@KKFE&KKKKKFIK=%A5K%KJ:B?IKKJKKKJKHK-KKBKKKJJFHKJJKKK.KKKKKJ>IIJEJKHK9KKKEF>K(KKKK2KCFK-CKCKJKKKJKE7KKGKKJK8KKKFG:?&JKI=KKKJK7KJKK9KKGKJF9;.CKKBKDK&K4KEKJKIC5KJIJ:K>@=#AI@7)J3@J7A?KKB>'KKJKEBGJKKHK?K*K6KKJ8KKDKKDKGKJ@KIKIEIKKJ@K6K-KKJKJKKK@K2KK:KKKK>0KCKK9KCKEIKKKKF;F<@KKKKKJGHJKKHKGK3KKKBKJJKD=KKKKKKIJKKKKKKKKKKF-KKKKIK8KKKKKKKIKJKH;A?KIKIKKK:KADFKKJ+KK=KEGJ)KHHKKKKKKKKI+JK>KBJJ=KKKJ=KKFKGG9KJKK7KKKJDKKJJDKHKGKKHKKKJKKD$KK9>I*JKKJ5KKJFKK=KK @rCer/1041/25_1773_CCS ATGGCAAGAGCCACCTGCCTACCGCTTTCTGCCCTCCGACCTCCACAATGGGACTCCAAGGTCATCTATATGGCTCGCAACCCAAGGACCTGGTGGTGTCTTATTATCAGTTCCACCGCTCTCTGCGGACCATGAGCTACCGAGGCACCTTCCAAGAATTCTGCGGAGGTTTATGAATGATAAGCTGGGCTATGGCTCCTGGTTTGAGCACGTGCAGGAGTTCTGGGAGCACCGCATGGACTCGAACGTGCTTTTTCTCAAGTATGAAGACATGCATCGGGACCTGGTGACGATGGTGGAGCAGCTGGCCAGATTCCTGGGGTGTCCTGTGACAAGACCCAGCTGGAAGCCCTGACAGAGCACTGCCACCAGCTGGTGGACCAGTGCTGCAACGCTGAGGCCCTGCCCGTGGGCCGGGAAGAGTTGGGCTATGGAAGGACATCTTCACCGTCTCCATGAATGAGAAGTTTGACTTGGTGTATAAACAGAAAATGGGAAAGTGTGACCTCCACATTGCAGTTCCAATGGCCTGGACCATAAGGATAAAGCCTGTATATATGCAACTAGAATGTCTGCCTTTTCAACCCATATTAGTTATTGTATTTTATAGAGCTTTTCACTGGAAATCTACATAAATGTCAGTAAACCAAATAAAAGTTCATTTCCAAGGGGAATCAGGAGCGAGCCACACCCGAATGGTAGAAAGATCTCAGGGTTAACTCTTTATTTTTGTAGTTTTATTATCTAAGGCACAGCCATTCTGTTCTCACTTGGTTCTGAGATAATGGTGAGAACAGAGGATGAGTTGGGTCTGTTGGGGGAATCTGGACACTTGTTTATTCTGACGGAGTTCACTTCTTCAGAACCTTCCTGAAATAAAGCAGAAACCGGTCACTAGGTCTTCAGAAAGGACGTCCCTCTGCCAGAGACTTCCAGCGGATAGAGAGGAGCCCGCGGGCGTGTGCTGATGGAAGTCTGCTTGGTGAGGCGGGCAGGTGGGAGTCTAACGCAGTCAGGAGCATTTGCATGCAGTGGGTGGAGAGTCGGCCACAAAGGGACCAGTTGTGCTCGAATTTGAGCTGAATTCCGCAGCCTGCCTTTGTTTCCTGAAGTGATAGCCTACTAATGCTCCCAAGCAGATGCTTAATAGTAAATTTCTAAAACCCCGGGTCTTTATCGTTCAGTTTGTTCTGTGCACCTGAGGCGCTCAGCCGTGGGAGGACCATTTTGCGAGTGTAGCCCTGTTTCACTCGGATCAGGTTGGCACGGCCGCCTGCGTGTCTGTCCACCTCGTCCTCCGTGTATCTGAGGGAGTAAAGGTGAGGTCTTTACTGCTTCACTGCCTAATTTTCTTGCCCAAATTCGCTGAAGCGATGGAGAGACGGGGCCAGTAGCCAGCCAACCCCGTGGGGACCGGGGTTGTCTGTCATTTATGTGGCTGGGAAGCACCCAAAGTGGTGGTCAGGAGGGTCGCTGCTGTGGAAGGGGTCTCCGTTCTTGGTGCTGCATTTGAAACGGGTGTAGAGAGAAGCTGTGTTTTCATTTGTAAAGGGGAGAAGCGTGGCCAGGCAGGTGGCACGTGGCATTGCACGGTGGGCTCGGCAGCACCTTGCCTGTGTTTCTGTGAGGGAGGCTGCTTTCTGTGAAATTTCATTTATATTTTTCTATTTTAGTACTGTATGGATGTTACTGAGCACTACACATGATCCTTCTGTGCTTGCTTGCATCTTTAATAAAGACACGTTCCC + A;(AA.F1B;=FDDGA()8;:9E9D'CAAB?.GIH>DIF*EB>@I@BE?$CEC<<<=1GHIIDE>FI>DIABBEGDC<0,%BC3@?FD=HA>@>:A78:84B=?EDFCC>8@9D;2DFCBBFB?II7IB.=9EDEED-C<<3=4+DCC'DEDBF>?GE?AE:GBGBII7ECCC>E,B>?@B5C@HDDEC86DFIA?HIEH?A*;F6*FC*BCG=7?<</=@@?F=@3EDBB=:2EFE3FFE@>CIGDBDJE:?B8>?1=?C>>>C=;FFE@<1BGGA2EB8C;A;EFFBAF>C@@1D?HH.C9GG8B32;CF:CBG>@+EGBAG9?>$6>B@BFH?>B?IGEK7GD:B?89(DGF2>H7H@=;6:=47+78>@C?=3@??A8EEBF;ADEED?@GGE8BCC@EEC9?0B:<@BHE?C+GG@4;FIB7HH;D/D$AEB>ACGEHDDHHHI?+EFGC9JF@:F90ED868A8D;=+<<;9@:6?9CBDE7GH7+FDFH5?B;/E?:B7;=7BE6E6CCHB@E>@ECFD@B7?BCCEA5C987G4=?A?:F7?8+A;:?BB@0D1:E%:?IIHGBH9=CFIBHHFE6DEFGABE>9DDDJ8GGG7HHDC@=1FFEF>@C8=<9A/D@F9CIFG=JI6B;F@D-BEH>EH'FF7F6EGGIEIF?>6G?>B>>8?5CE@5IFGG0G@.BCIFIBCEEF>B7A;>GFI?6H&GBIHFID4FIGBAD>.GFD9B><4?7BAE?B=B072;>@.?@G@BG@CC8C%>BC6B?E8DFF,F9E>>2=F%:;?8F:E@JHGB?ED)@B?HGJKGFGJ4K@JDHKK>/CIIH>E:JABHKK>EEKDBHJII?CE7K=IEIIGDD?D?D@D/>CE.HF5KI)DCCCCHFJCIFII?JGEF,@E?E?EF/F@:=9.DAK8IAHI-DGJJJ)GB7DIJFFH;AIIE*K<1AA2EF':@<;@GEH9IHHJGKKCHGKHGHDBAFHEIKHC/JI@JB:JG3>EEGFG;BGA@E=BHG=C:D?1HHJ3BGIJGGABEC8GFK,EIJHJ9JKKG1J-IID=I@IHHGACJ>KJHIJCDIGC0KH@GHDFJHKBKH;>AKB?IBED;GFFJIE?HHJCIAGCEEAF.FFGA;FDEJ8JHBH:HJHD@GJI7IEE7HBJ;KKJFAEEDDIH:GKDIJED=HE@D;9GID<7CH.8>>B:AIDFEA/H;J@0JJ>4BI5FGJIDA6IHGJC@GBIJF5EJJEIFHD;?9@4<8?BDCJKKEGIF6CA4EDBDDHBFE=,C@FB;B?%HGG@EF6BBHCDDDF>?FGGA?BC>9:8:/34:8AEGDA@GDJGEGFAEAHDC@CAD>6A3B@?ID%F29@D>C=9B;IG @rCer/1042/1828_63_CCS ATGGGGAAAGAGAACGTTTCAGTTTAAGGTCTGTTCCCGACGGCATGGATTAGCTTCCGTGCTCTGAAGTTGTCCTTTTCATGGTGTCTGACACCAAGGAGGTTGTTCGCCCATCAGGCAGGATTGGATGGAGTCTTGGTGTTTTGCCTACTCAGGGACCAAAAATGTGTCATTGACTCCTTAACAGGGACCTTCCTCCCAAGGACATATCCGTGTTCATTTTTCATCAGTTTTACTCATATTCATAGGTAGATTCTGTTAATGTGAGTTGGAAAGAAAAAGACCAATTTGCACACCAGTCACACACAAGACAGTTTTTCATATAAAATACCTCAATTTTTTGTATTCCTCATTTCCACCTCACAGTTGTACTGGTGGTGAATTTTAAGGGTCTGTCCTTTAGCTTATAGGTGATGTTTCACATCTGGCCAGATTCTTATACCTCCCTTGTATACTTGAAAAGGTTCAGAATTACAGGAACAGCAATGAGAATTTGGCCCACTATCACTGCTCATTTGTTTTCATACACATTCCTCACATGCAGGAAAATAATTATATTTTAAGAAAATGTAACTTTGTTACATTAAAATATGTTGTCTAGTAAAAAGTTGATATTCAGTAGAACAAGGATCGTGTAAATAAACATCTATTTCACATGTACCCAAAGCGTTTAAAAAGCAGAGTCCGGGGCCCAGAGCGCGAGCCAGGGAGGAGGAGGTTTTTTCTTCTTTTCTGTATTTTTCCCTAAATCGTGCAAACATAGGTGAGTCTCTTAACCTTTCTGTGCCTCAGTTTTTCTACCTCTAAAGGGGTGGGATGGTTCTCCCAATTGTTTCTAAAAACACCGGCGCTTTTCCGCAGCGTTCTGGTGGCCTGAGCTGAGAGCACCATGTTCAGAAGTGCCCGGGAGTGGCACAGTGGAAACTCCGCTTTCACGGACCGTGGAGTCCGCTCGGGACCGTGCTGTAGAACACACAGCCTCACGTGCTGAGAAAGCAAAGGAAGCGCCGGGTGTAAAGTTTGCATGAGTCCATGAAGCTTTAGTTTTCCTTTTTTTGTTTTAAAAGAAAGGGTTTTATATGTTCTATTGTAAAATATGGAAATTAAACAGGGACTTAGAAAGCCGCACAGAAAGATCACCTTCCGATGGCGTGATGGGCTCCTGACATTGGCCGAGGTCTGTGTTCTGAAAAAGATTTCATGGCCTGTGAAACACGTGGATTCTATTACACTGGATTTGGAATAAATGATGCTGAAACTTCCTGCTTCCAAGCAGCTCAGCCCTGATGCTGAACTGACACCAGGCGAATGTCAGGGCTCCCAAACCACTAGTGCCAAAGGGTCATGTTGAAAAGTTCAGAATATTTATTTGTCAGAATATAATAATTGCCCCCCACCTTAGTATTTTTGCACTTTACAAAAATTTAGATATTGTTTTTCAGTGGCTTGAGTGTTTTGCCTTTTCAAAGGATAACTGATTTTCTTGAAAAACGGAGTATAATCGTGAAAGAGAGGAAGATGATAAAAAAAAAAAGTCAAATGTTGATTGGTTGTGTAAAAGTTTTGTCATATAAATGTATTGGGGAGCTTCCAATTAGCATACATAGACACATGTGTCCATGGCTAAGACCTGCTTATATTTTGCTTTATAGATGTAGTCATAGCATGTTGTTAATTGCCTCATGTAAATAAAAAGGCTATTAAGTTTTCCAGTAATATTTATTAATCTGTATGTGTTTTAAAATAAAATAACTTATTTCTAGCT + 66689+26+9:9:):999386584-:797:931:5;7829993655:696.1-9;746639:8:561.67/54:6464-1-6:51358:8995;:;89:29-8,5;797.4(6262944.849;597667.:808816323:480567-78:5554.9848878%9:7879449:8521/8/6'6097/'878544/9;4939:9844884.86::7415888)958513762)0+48286;:67048588549-989=9;45551>==:99>8-4379:%;75;=5;>-=;/28>79=:>>>>>:>8)&7=:>=?;:3::669=>>2<><:<<=6=>>=709;*9.8=9:.<52/7/=,<>8=:>=9<47>===53::7<-2=:)<2><68==3<=7611998<8807=893=4=<=947=<:;(:::7<<:;7:96478?9>??5:694;6/5;/=???5>79656<;1<46=;:9=;?><<>574:::*5=(?=?;=57<6:<6=9>4476;89;:<=(9/6::5<>=783'11<3439:=9:;;-.=79559;?;=69:====+<;>?7>6934?2=>>:4<;7-6=<:;.9999:6178;<(=;/.079=8:9:2:<<-8=:?<<:<992;;<0199$<<:=>=?;9><>=345:>58<7-.:789$.==:)9418;>=;:9=>09619>>;>;=><<<5:??7><52?==<6:<<<9&6:;;<>91;6=9<:;==136*-;7.,=8341<>?>:817:;:78.;7:6>?8><:8:892=;=7;==*8;3?:6;88>9;>>1<;<)4=>:?:;:5<2:2=9=;<0:*/763)0):8>8><;9:8(9,9:8=>>?=:>=88>>9450<66<><78>:>7;=>??8;903:7:;;3<3;,=7>?49;::>>=:+2-9=84>5=/;4715?:==<;89>;089;8868=>><==199<;)82;*9::<8><4177<8.<<>6>>9=:>>;>:>7??<>>>=5679=9,=0::;<=:(6<>:0<==/>??;?>69883224778)879=;9:=<:-5=;=1>>3=76:)717?:9=77$479$<99457:+.:9$<<=>::1<8>:;>8?848<=7=>:751===>;>6?==2>6:3?=889>;>?=8>=8>;?=:=>?><>:<;48;====9,2.?69:905>:7>>2=><*:;8?>==1===0<5>?==<9=>>?;5,;217;;>?5<:959>?7.<==9?:=82;;>>1==4?:>89<2=>3=8982284=7::177:=:>=?9=58:=52;6-6+7?;?8;>24:>,<=<=1.>97:==<)<3<=>=39=<;9<1=>7>;9<7:4><:>>4>==9?9:?7;4<=><>>6;?8=??7;;<,?<0::698<<=>>88>98><<=1>=87<2;6459>>7*7;,<7<;?=?8>>87:5;;;;;;:;:7%41<===>9;>:<7>=>8369=9<:97840<8<=>>:99><=:><:=7<9?>:57.4==::;7<9><;-6:9<:=2<=8:73555.9=98=98>=>?98;>?<><8???9<=:;?679>=<>:?98;=>3;96==?>68??.67.?7==8:;36>:;<=;%;>;2=<;<3;>:=?;=<9582;985 @rCer/1043/2532_53_CCS ATGGGTCTCACCAGTAATACAGACTCATTGGGTCAGCAGTTAGCTGTATACACTGCCGTGTTTGGACCGTTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCAACTTCAGTTCTTTTACTGCAAAGAAAAGAAAAAAGAAAGCAAGCAAACAAGAAGACTCTGGCTCTGCTGTTGGACACAGATCCTGACCCCTCTTGCTTCTTTTCCCTCCTGCGCCCCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACGCACAAGGGACGGCGCCCTCAAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACTCTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGGAACGGGTTTTGAACTCTGTTAACATTTGAAAGATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGATATAAATTCCAGTCTGAATACAGGTAGATATTAAAGGGCTAATACAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAGTGACCGAGTGACACATGAGGGCTGTATGAATTGAGAGAAAAGGCAGCAAGTAGCGTTCCTCATCATTCAAGTGCTACCTGGACACAAAGGCCAGGACCCGGGGGTTCCAACAAAGCTCAGCTCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTAGCGCACTTATACAAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATATGAAATACCTGCTTTTGGAATAAGCAGAATGAGGCTAAACATGGGTTATACAAAGGGTATCTGGAGACTGAACGGCAACTTGTTTGAAAACTGACAGTGTCACAAGATGTACTCAGTTTTGTTTCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTTAAGGGATGTGACATTACCTCCTGTAGATACGCTAACAGTGTTATTCTTTCATTTCCAAGGGTTCTGTGTGGCTTTGTGTATATGTTTCCTGGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGAATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTTGCCTTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCATTGAATATAGAGGTATCAACTGCTGCATGTTCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTGTATTGGTTCAAGTTACCGAGACATAGGTGTGTTCCTTTATGGGGGATGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGATGTAAACATGTATTAAGCTATATTAAATCTCACATACAGTTCTCCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGTTTTTGATGGTGGTTTCAAAGCTTGGACAGTAACTATCTTGAGCCCATAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCTTTGTTACTAATGACGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTATAATAATTGCAAATATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGACATTAGATTAATTTAATTTATCTTCGGTAACTTGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACATGATAATACTGCCCATCATACTCATGTGTAACTACTGTTCTTTATTCTGCTTTCTTCACCATTTTAAACTTTGGACAACCAAGCAAGCTCTAACTGCAATGCCAGATGGCCTTGTCCAAGGGTCTGGTGTTTGCATGGCAGTGGGGACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTGCTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGTCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTAGCACCCAAGGCTGGGCTGGCTGGGATGCCTCTGGCTGGTGACGTTCTCACACAGGCAGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGTGTGTTCCTTGAGTAATCATTGTTTCATTTTCATTTTTACAAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTAATCTTTCCCGCCCACCCCTTTCTCTTTCTCTCTCTCTCT + F:GH3F@JKEJIIJJKHFIIHKJH@ACJGFCJFFHIJCIJ2GGKHEFIH=HFFGHK:IIIKK=IFCICGK=JAFG;JKEGIHK8KIIJFIGGFGHJKIIIKF7JEDJKHKJAJKKJHJFHDGIAIIJI2IKIIJJK=IJIE;FJJJKD)DDJ:HHJA=GKKBJJIDB0FDGHECJJHEG@JGBGI?KF9DGJJKKFJDFHKJJJJI9FJI8HIHJIKJHJCKKKEDCJFIC@J:HEHGIHCKFJHK=IGKJ>CCKKJFA1JJJKHGBIIFBGKFJGCJCJKHHIKHHI:0?>D6BJ=IGJK3G@KKJABHJFJ7J:BGKKKEJIIKKIHCKIIBIEFJDDI?KKFIIKGFH:GGG5H@IIKEKK=I=ICIH8D6KGGG-GJI4JHKJ=JFHGHFKG:9IIJ0FECJFHIKA->JIF6JHHJ1IJAJKEI@4CDFGJKK:IKE=GJ;FGFBJIH9DH=KEKGHKKJJKFIHHIHKIGKJHAJ@IBHHCFG7EIIGJHJKB?CCHHEJJ;D;KGB;FJFHEFHKHCE>,A>IHIJIJGKIJ?JJ@DAIIFB>@>:AHJBFIJKFKCKBHJ;KAF>E;CAJ@HHH.@JFAAAHBGGJ5F;EJIE@;KJIHKIHFF;EKJJKGFF3FJKJJ>GE?B?B(JID=GD@IDJH?KGJKIHKEJHH1F6HJFIDDHGIH-GIIAKKFCIGGIKKJ:DC14G;>?3C5GKICJKIIIHJ6IIH@HJKCJAKGIFEJKDKKKKKKHKKH/JFAIIHIIIIKJ?KJA@JKGJAJCGJCJ;KEKDKHJ;GIIKGKJGDFCICFHGFEHD:D?KKHKFKKJEJEEJ>GKIE@GAGE3;GGF?IKGHJJIIFEJKEIFGII>GEEI?F@HKHBIJ>FHHCIH?KKJI:GAAHIK8FBKDJIJKJG4DJDK>;IEIH6IJI4GFKFKGBHAFGKCJJGBKKKKGGKI=3=3CGFFCFHDIHJHK5CEAJFDHIEIIIJ;C;HCGF=DCHKIDKEJK8HKDJIHJKIIJHIIH5JKKKIBHJIIKK*HKHH:GDHJIDD??IEIFJIIDGCG;AGKK:HFE'KF?FBG6;>?GHJAHJKJBKGKIGGCEJI8HHHEFFICHCIKG@BCG:AE=>%DDB:CIEJAA?B?*J@JKHJGIH@GHGFH=8I>A;D?K=GIKIDHEHKHKH;FGKKHHBJFIJG=JJKIIKKFJKJHJHKKAGBIKKK?HFKHII6DF95>FG8DBHHEHH%FK:JBE>HI5D>EK=JFBHFDB)BFHEGGAI@H:EGICKEKIJ;JKKCJKKBJH3IJKKKK5JK7KJKADKKK>KJ*;KKBKB?HK@KBH8@JKEKKJFJKHJGKKKIHFK@G@B@I5KFJ@HHK0K6KK8IKAEKK9FHJKK/KDDJKKICHD*AEIJKJKKK;EG4HFH#AJJIJK:J;K9IHIH*KJKIBIKK@JJCH'J6GKG>@KJJKJJJK?JJIHFFJGI9JKJGKKGKK=JKJJJJKKEKBIC=II>IKKE@&JJIG,CIFJJFJJKFJJIKDHKKAE:IKK0KHJKKK7KKJ?DJEJK0BIKH1ABGIH?FAIBEJHF4@8ACBD7EJ:BDKKKIH/>?E2'9IK'5FDA#>J37<>9F @rCer/1045/25_2697_CCS ATGGGGATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCGCCAAGGCGGCAGGAGGAGGGTGAGCGGTCAGAGACCTCCAGAGAGCGGCCCCGCTGTTTGTATCGCCGATAGAGAAGAGAAAGGATGCACGTCCAGGAGGGAGGAATACTCAACTTTTCCTATTCAGAAACAAGAAAAAGATTATTCAAGCTGTGAGGACAATTCATTCCTTATTGTTACTGGAAATACAGGAAGTGGTAAACAACTCAACTTCCAAAATATCTGTATGAAGCAGGGTTTCACAACATGGTATGATGGTGTAACTCAACCACGAAAAGTAGCTGCTATATCAGTTGCTCAGAGAGTAGCTGAAGAAATGAAATGCACTTGGGATCCAAAGTAGGATACAAGTTCGTTTGATGATTGCAGCTCTAAGGAGACAGCAATCAAATATGACTGATGGATGTTTACTGAACATATTCTTGGAGATCCAAATCTTACCAAATTCAGTGTCATTATTTTGGATGAAGCCCATGAAAGAACTCTAACTACGATATCTTATTTGGTTTATTGAAGAAGCTATTTCAGGAGAAGTTCCTAATAGGAAGGAGCATTAAAGTGGTGGTAAGTCAGCAACTATGGAATTAGCCAAGCTCTCTGCATTCTTTGGAAATTGTCCAATATTTGATATACCTGGAAGGCTTTATCCAGTCAGAGAGAAATTCTGCAATTGATTGGTCCACGAGACAGAGAAAATACTGCGTATATTCAGCGATTGTGAAAGTCACCATGGATATCCATTTGAATGAAATGGCTGGAGACATCTTGGTTTTTCTGACTGGCCAGTTTGAAATCGAAAAATTGTGAGTTACTTTTTCAGATGGCAGAGTCGTTGATTATGATTACGATGTTCAAGATACCACCCTCGATGGCTGTAATATTGCCATGTTATGGATCTATGACAACAGATCACAGAGGAGAATATTTTTGCCACCTCCACCTGGAATTAGAAATGTGTCATATCCACCATATTTCTGCAACATCTTTGACATAGATGGAATCAGATATGTGGTAGATGGTGGCTTTGTGAAGCAGTTAAATCACACCCCAGATTAGGTTGGACATCCTGGAGGTGGTTCAATTCAAAGAGCGAGGCATTACAGCGAAGTGGCGAGCTGGCAGGACTTCTTCAGGAAATGCTTTCGGATCTATAGTAAAGATTTTGGAACCAGTGTATGCCTGACCATGTGATCCCTGAATTAAGAGAACTAGTTTGACATCTGTATTCTGACCTTAAAGTGCCTTGCCATACACGATGTCATAAGTTTCCCTATTTGGATCCACCTAATGAGAGACTTATTTAGAAGCTCTTAAACAACTTACAGTGTGATGCTATTGACAGGAGTGGCCATGTCACCAGATTGGGTTTGTCTATGGTGGAGTTTCCTTTGCCTCCACATCTGACATGTGCAGTATAAAAGCTGCTTCCCTGGATTGTGAGATCTACTACTTCCAATAGCAGCAATGTTGTCTGTGGAAAACGTCTTCATTAGACCTGTTGATCCAGAGTACCAGAAGGAAGCAGAACAGAGACATCGGAATTGGCAACTAAAGCTGGAGGATTTAATGACTTTGCAACTTTAGCTGTCATCTTTGAACAATGCAAATCAAGTGGAGCTCCAGCTTCATGGTGCCAAAACACTGGATTCATTGGAGGTGCTTATTTCTGCATTTCGTGTGGAAGCTCAACTTCGAGAACTAATCAGGAGCTTAAACAGCAAGTGATTCCAAGAGGACCTTTGAAGCCCTAAACTGAAGTACTACGAAGGTGTCTTTGTGCAGGCTATTTCAAAATGTAGCTCGAAGATCTGTTGGGAGAACATTTGCACAATGGATGGGCGTGGAAGCCCAGTTCACATTCATCCTTCCTCAGCACTTCATGAACAGGAACCAAACTGAATGGATCATTTTTCATGAGTATTGGTTACCACCAAGTCTACGCAAGAATTGTATGCCCAATCCGTTATGAATGGTAAGAGATTGTTACCCAGTTGCATGAGTTTAACGCACATGATTTGAGCAGTGTGGCCGACGTGAAGTGAAGAGATGCAAGAAGGAGATGGACAAATAAGGAAATGTAAAGCAGCTAAAGGATGGATATCAAAGACGTCTTAAAGAAATGCAAAGAAGAATGTGACAATCCATATTGATGCACGGCTCGTTTCTTGAGAGAAGCAGCAGAGGACCCAGGCCACAGTGACACACGGAAGGAACAGGCTAAAGTGGTGAATCTCCAATCAGGAAGTAGGAAAAGCAGCCAGAAATGTGCTTCTACTTTGCAGTTATTTCAGACAGCACTACCAAGAGGAGTGGTCAGCACTTGTTATTGGCCTATGAACTAAAGCAATCAAAGCCATAAATCAAAGCTCATCGTTCCCATAAATGCAATTGTCAAAGAAAGATCGGGTTGCATAGTCATAAGCAATGATACATGAACCAATGAAAGACAGTACATGTAATTTTCCTCAGTACGTTTTGCTGGCTTAATGGTATCAACGTTCATTGAGATGTTTCAAGAACATTGAGTTGTATTTAATCAGGTGTACTCCATTTGCTTGAAGCATTAAAATTATTTTCCTTAAATCT 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2,&138730.1:39'68495:965342'3438829--94+/0'87395-99:25,+&%565:$57&889:55::5:*99792::55'6(3267)96646-%82&773/6488:63'2407(89/70$(/238,4*95/%157(789:::58/636336/0'45-3%12,87--+2753&82$66$5626:(%$393+$02(899-994.::74,234(00&345732697001356415563'93/16186336/6#0,$)02:762-:7;:5494)94::::;1#5426:-+5258&62:-676725978.4/406252,2-(673,216976)4,*.$($&4+/*592/44:-9597/8557*60-058+79708116:57098:9:36639>;93:7*76192>?=<>;-$8/>;:6;?2<33648;37,$/<66::7);<;<:<9,989/-88336?)762<=61<183378**02676)<>:;=847%753606'8*/33.32,5.5.,9/46/877/&6727,::-:94(4,-94+77(6142:06..67.8:9::.383.98:79-5445,#56744669%57)7*840398'48*6.6&5%-157.8409;00((1003745:23)6225/&3#-11/,83+75*%$5833-,:95246765/4::9;6983/8:69:4(-/8.*35;%66*648-8$06-&778816488:95:+7,:4.94614:9155/47564&275688:951*9774;+84.9508(8/:5958(34381-2,2/4,-4,32'6665*83./$015614*93.%203//3;/-5:956-76:9:6927,8-121428595;'88889::339.7&1712:98,98489'577$#56)5:918)1.24/854663569-16,&*&+948/:4/51&22925)8086367603+7+%74166,8(87$/+(804136*;-12%8235:5895%'23-&3141/40%134<21).08(6'59<<5+<:8?=6?=:=:).09*0-,$/841,/00)'968?962$26.58-,:=9?>829.89685(/61306?789:.'6;<3131:6;1892:/%4<+:9:99498;94-7-679:9;%&28<37<'6;.:1=.8/550.8:=?888868.*%)0(81,8886450'1>96):'9>;936;;>55%:70872?><2:5:3=579:;*1,:4+4208<:7:::>7,/5-))778<+9:81:7>:?7(8;8=*3*689.0>974627<:=;34%42:&56.20<7:820;8.19:8=><46#4<78>7;+;)16998157>>,91:10731<;;068555&.7:*:;5:.;<1:17-613::3952698;>97::%9:4::=4:/818/124583(/5(45883/6)1;3277231*0=5/8.85<7..):6/;79<-4'84)67:<70799?();720==2;3;>93;83;0593:868<6718,:11($3/4;<,5,168?;??6+8..7560$474:89<+6/(=%79762.6';=7/931418/2*44/009.800407:--/>*5'<680969976770086:5#,.041:-.665(479.20:+.25%02&79877*54/)%3+,64&$6.32233//652,7453226)7754-3%2/6569'29/31'68:,$1-514%446/95/588*89--8366(5791&52,668:792+899./2205&11)55-9846692607//.97600*$%)5:,94/260,74+14(+(30544,)3+4,9:9%%)'53**481&3,5459951456:46+(45-7976::13:868'544)78404+24-.15(4364.08,9*5/21-72*#450,07/.+-783'756929;767-9534.8&)1(&6.**)5-82:2,*-&79/45/46384-&&$7*7,741&4394-:+565$457746562%6707100680:0.7258.4/9:79.99-63::52,1*65*52/58-5/3858($21+-)(%'#/*%/3+50,2-621-*2(3'//'.551403-40.45/+'0*.+/21-$202100(.65201*-#*))+0.54$/(213-1*2.*%/1455--$22-,-(340031)1)20044/)'$,/14'323++51116566.#.-*44'11-))*%.-.#/)*%43*0+'/*$24*/052$2)%-202/--1/12./%445165/0006&(55.+.)045(45220+30-)3,2,(#+&#&1+.&22'1-0-/461)/&3#')/046*//.035$0223645/5.%&').//-)02)2-2*430$/)*35+4432/).*231/)./6054+))$,).4+441)+.,4*/5./0+316,3140550+530/$,-3*300'%#,(&%*-*0.00/+363$46%31'1)13+2115*21,0,034$43-.0/.46-2,%*/36/)05*5)/122501/0144*2-1+104(23403%.21031**%)(,34#*-/5*(.2.246640/,/%-1-.#/65110$1,.&$/0%0155454'22$$++,4)(+3,+/-211/-+0)124+-$/10,/5564*530*#44121.***&/0225'*3040601&-.03, @rCer/1049/2018_58_CCS ATGGGGCCGTCTCCCGCGTCTCTGTCAGGCCCGGGGCGGGTCCGCGGCCGCGGCGGGAACATGGAGGAGCTGCTGAGGCGCGAGCTGGGCTGCGGCTCCGTCAGGGCCACGGGCCACACGGGGGGCGGGTGCATCAGCCAGGGCCGGAGCTACGACACGGACAGAGGACGAGTGTTCGTGAAAGTGAACCCCAAGGCGGAGGCCAGAAGAATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACAGTGAGAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCAGGCGGTGGGAGCGTGCTGGTGATGGAGCATGTGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTACACCTTGAGAACAAGAAGCGTGGAGAGACGCTCCTGAAAGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTGGACCAGTTTGGGTTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTTGTGTTCTATGCCCGGCAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATCCCTGACCTGTTCCGTGACCTGCAGATCATCCCAGCCTTACTCCACGGGGATCTCTGGGGCGGAAACGTAGCAGAGGATTCCTCTGGGCCGGTCATTTTTGACCCAGCTTCTTTCTATGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTACTCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACCTGAACCACTGGAATCATTTTGGATCGGGGTACAGAGGGTCCTCCCTGAACATCATGAGGAATCTGGTCAAGTGAGTGGGCCTTGCTCTGGAAGGGGCCTCAGAGGTTTCTCCACAGTCCTCTTCAGGGCACATTCTTGTTTCTTCACGTGGCCGGAGTAGCTTTAGACTAGCGCAGCAGCTTATTTCCAAGCCTTGCAAAGTATATAACACCTGAGAGGAAAGGTTTTGTCATCCCAGCGTTGACCACTTTGTGGGGGTTTGTAGGTGGAGGGAGCCGCGCTGGAGGCAGGGTGTGAACAGAGGGCTGTGTGGAGTGTGGGTGACTCTGAGCCCCACTGCCGCTGCAAGGTGGAGAAACTAAGTGATCTCCCGTGGGGCGGGAGAGGGTGTCTGGTGCGCAGGAGGTGGCCGGTGCTCCTGGGCACTGCTGCTCGTAGGGCACCTTCCCGCCACTCCTCCCTGCTCTCCTGTACCGGAGTGTCTCTGAGCTGCTCGTAGGGCACCTTCCCGCCGCTCTTCCCTGCTCTCCTGTACCCAAGTGTCTCTGAGCTGCGTGTCTCTGAGCTGCTCGTAGGGCACCTTCCCACCGCTCTTCCCTGCTCTCCTGTACCGGAGTGTCTCTGAGCTGTCTACGTGGATGCTTCTTGGTTGGCCAGACTTGGGCGTAGATGTGAAACCATCTTACTAAAAGCATCTTAAAATGACCAATTCCAAAATCAAGCATATTCCCGCTTCTTCCTGCATGATCCCTGGGCTCTGCCACAGGCTGAGCAAGTCTGTAAACGGATTCTGGGAGAGACCAAGCCGCTGGCCGTAGGGTGTCCGTGGGTAAATCCAGGAGTCTTCATTGCTTCTGTTATGACCCCATCTCTGCCGTTTTCTAAAGCTTGCTGAGTTGTCATTCCTTTGCAACATTAAAATACGTGCTGAACTAATATTTTTCCTTCCTTCAGTATTGTAGTAATGAGAAATATTTCATGAATGGCATTGATGCTAATAAATCCTTTGCGCAAAAATTTGAATAAACTTTCAGTGGTTTCAAT + HIKJFKKJFHHFJH@FEB6CHIKHEKHDGKHCGKKGIKHEAGFIFG3JBCAC=EKI@IEJH@IGFHDJGC,>JHJDC;GHHGBIH>FH=GDHHKIJHJHJJJIJKFJD7JKI9J?C=FKFIKIK=J@?ACGHHIKDJJHKIK6JHJ;HIKKGG:JJIK@HCFK>DCE2J8KIKKFDKIJJKGJ=JGHI;EDFFIH*CHH6EFHJIFIJIDIIJKIAK8AIG>FHEH9HHI>IGICJ=IGEF:FJHIKIF>FGHJK1IKIKKIIFGHIFADEF=KJKJJGJHIEACJK?HIJ=G;HCIHKKKEHHEJEICEFHF5HHGCGBFJBGG?GI:GFBKIJCFKIDIHH;FFBEI5I1IJFJAIKJJHGJJKJDJBFEFH;A@JHK5KDCFHI>8EJJDJ=H=JKGIHAEKJIIFEE:GIFB:CGGJJJKKIKIKCKIJJC>HGD?BI?ICGJ:KJGGCCJ5CAF@@JKJI5FH@CA7JHFIIIIGEH@BG>F>FIHF>)C@7?>EE@HFC3<3GHDBFHC4?JI@H4DFEEIEHIHIF@<3@9BECHH9<7ADD5=DI;GBHEDDEC.FH>J=HEGFIIF?HIGJAEHF6@I?F@FICHFIGFG@>:EH=5>FHG9G@C9@BC0GF@GF8FBEBI<@@;@FA9FBGDEG1FFCFCEFI1GD6C>FHB:>-B@8GFB@@IAFEH;C89C@HCFD@@CJH;@3>E>CHF@EG(BA??BC;@9GDBBF>AFBG?GEH8EGAH>G<>DH:E@HFFDB=EDFE=IDE=A?C@DCF@FEG3EAB;8CBFE;D:HCGIGI@F4HIJJH1DFFCECECF7FHH5C:58?=@C4C@>E>@4@E7>EBCEDF@;EE6>BJD?IIIC?A?E99>EEGDAA7GHIFGFAABAD9CGFDAAD?IEE=GDGC8CBIH2:EAFG9EF@GEFDFCF=1@@880D?BBFHECHFDGE8EIFGE8??7=HECFDE>=C*><6GEEG?F?5?@?>@EDC6AFB6DH9AC;FD;EFFGCEABH6CF:DG=EIGJH@GBA?=AFD:EE<@A>@9A4DCE?GF@GBE;=FEEEGD19ABJ:FEFBIIFC=IJ@IF?>G1HCAIIBFHI=FEDADA>0I>EDHDDAJAGHEHE@A8FEFFGCDIID55=EEEH?ADGHG7FG7HCH?F>E@C1A@:;FF=CG=EHFBA@DHA.<<:>:ICGFAEGC2EHGEFAGGED+HHGG=HCIDH>GFF08FG:DIIEAH>FE?HDF>FH5HEE0AHEE8EGJHGDE@GF?E=DIHH7DBDCCCHHDD8HH@C@?DA%EICDFGEAGDHAHFGDBAB,FBEHEEID$DEJAEBEDDBIJ6?<<2,:9FI?EFIIFB@IFIF@DD=;IFCB?6%GGE7I?B+62>+CBCEFCFEGGBEIFDHIHEGB8GHFEJECFIGEBF=4F>=FBFDEEIE>E@@E>D3>@:AE<<@>;@IF;AFHGGG=DC?ADFCHE;@>D;EGCD.?F>?@CA@EB=8:;)CA;=CE8G07D;G>CIF>EHBG5<9?@C?F@?D@F2?>AGG8;7EH@E>8FGEAJC>CHIF8IE@@HIIHGICIF1DFC;CAF=2C@9=F;8CH;BGB7<@CIDFE;>G@BH:3FFFD@BFDC2=;H7@3F?C?GGBBDF>GEF>IC?FHE8D8HIHIHFHD;=C7>CGDFH@C2FC>B@G5FCIEH;@EHADI?AFCA;@G7GGG@>%DFAHD>EED=GF=58D>D'CDBGFICC)=CAIGEEGCDCB>JCECE7HFHHICEIHI=?3=26EAFHFHHHAEFFHDFGIF@EB:FGG>H:D,>@+>C9HDECFJE<=AGF/1DB??8DABDFGE7>B9C;G?IF64?JJB7CG7B=GGF>IF=>?=7??';CAFDBB64=IA/@7:=>:>IB79F3GIBFGECE9BCE/IFAFEJ8@EBI5AG=A?B=>>;56>FIE1@>DFAG@;EACAA>:9GIFA8FD>8FHF67;0C7CF@>@E;@%GG8C2@989@3A@@?BE>@F*AIGHBGHI#G?IE9>59=IFG>EH:B38C>E?.F@G6F>=(=CCGCHI=?FD=HI7H'GIJJ;HHEC%F??FHCDCCFJ7F3GAB>C;AB?>0=:DEB7C>=8IFF6?6=H?GGE?FHJ5F>?$=4:>2?>0JB@?CC@HK38=AJJDFFHAHJ29EDGEC7JKKJDE:BCDJF:D@>CIC2JIGC7GBBGDHAA/;@FGGIGIAIA>BBKC>CH.?9FEGB<=IHFKGCB=I>&CEII=J=7EFIF@?II9GI&CACDGH=@JAHDJHGH$EIJ2EADICJJCEF8BD9IADEBJ=KH9KJGHHH-4>FADKAJ>K?JEEHG'J=8EG?DAD>7GJHJCJ?II>JI9HCCC;?8AGDBJKEAC:@IGID>FDHI;HDKGGIGJGKI/JKIJA5AH>)B4ECBGIKC@@H@JH=::=;=4<,<;67;<6>=95;:18>>=>>9=<9;7:+;729181>908:7<>:::15.<<;<5=1???9;;88/><917;+<794;998<=?>>;>9=06=:=><;?85;4<<4=8<>><>=368<692;9=5;?<;<6>;:5063:2=%7-0====9=:==:;1=58*44&;80<4194;+/27199:<=2=3>590=>995&029;989370<:0?;1589;99?<<5=5935=9;:48,<:;?9:5>3;<<=6<>=:4;??>=?:?>9:7&8<=<=<<;;89&89;;<=<;<===<8?9/9<9.:>=;99=<-:=9483;8=9;=90==>==>;?5<:=>8/4:735=5:?>?9;(=970)651::=;848+896:4:'6382==<=.;==<:=9486;:%6:8876):85:97;278>,34909<<9:?=29=5<:*<9>?><=364>>:>8=/%:?93=>:;=:; @rCer/1063/2022_56_CCS ATGGGGAGTTCCGTCGCAGCCGGGAGTGGGATCGCAGTTCTTGTTTGTGTGTCGGTGTCATCGCCACTTGACAATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTTGAGGTTGAGCCCAGTGACACCATTGAGAATGTCAAGGCAAAGATCCAAGATAAGGAAGGCATTCCTCCCGACCAGCAGAGGCTGATCTTTGCCGGAAAGCAGCTGGAAGATGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTCGAGCCCAGTGACACCATCGAGAACGTCAAAGCAAAGATCCAAGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCTACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGTGACACCATCGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATTCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGATAAGGAAGGCATCCCGCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACTCTGCACTTGGTCCTGCGCTTGAGGGGGGGTGTCTAAGTTTCCCCTTTTAAGGTTTCAACAAATTTCATTGCACTTTTCTTTCAATAAAGTTGTTGCATTC + EDEED4B9AAD=?B9=BC=BA@9F;CCEBECAGBA;DE?32DDFA59B?@EED?2BD9CCBB@A;EBEBBD;GG@AB=GCA:==BCB8>?FEFDC=BAD=BB$@DB=>B;@F4@@BDECDB>BECCE<@EDC6=@<>F?CCCAC?FAF;?=CAFCCC;D=@BCD9:E9CB:;CF<>@@@DDAD=?>D?7=887D<=?DFAFE;EFD@C>=7<&A@>:;B3?BGD=?BAECCCDB?EAC@C6DDA3=6EE=@FEE8>EA@D84=E2=BCD;=4A>@8;@DBC6C7=E7DD>DFGD>?EEBBE>CFDA8?<8>?4>@3>D>@F@FA=8;@D8;ACA:?@64<@ADA@B=:?:ADB@0@EE8.;.BC?G@@B@:D?D@=>6BAAGC=A;E<=B<5D>@;:><>)=GAG;CG8AE<@?BB3C4A@FC@=FF?99A0@9>6=D?A1;AB=D>>DAE@EF3FF@EF5BDCADAD7BB?E>@BEAB=AC=>>BCBEAAEG/CEE8AD:9>A7EAEGEAEACD>E@?BADD?C9A?A:6;D@EFB@7BDA8?;4A>@<6:@;ED@EB@AF3DCDBAEF<@FACFBE;??F;F??A@0D?D@D0:@:DE8BBB@1@EBCCE9BGGECC0D>DF?EF2BECC?BB=E@AB>GG>GDFDGGA?85?7>?2EDDF?AC?>AD;DFDEDDB4:AFCC=DEBF;;?AF>?8=>A&@FECFGF?EGEGA<15EEA;CD>EEGE0?F>8D@BBA=@)BCDB@DABBFD@BC@BF=GCDC;A?BBC?>9?E9ECBCBFFA6:HE5FFBIGCGEFFBIH4AA@C?H@HJG7BEHIFGIDEI?4GAIJGIHEEJFFGDCE=IFBBD8HDGIIDG?IAJ8CDAIHAABIDBB??2=DAAA>FD3BDB>=EBICDFBJHEDCDHIIBA?4BEGFIBAHIAGGEHHFCDA8DF?F=EEBEEIICGE81?+BE>?9A6>5FGB@CEFC?B7CB3C?FBCCFA=DAAC2D>DA@BBG<7DFGBAC:3C=?E6EABDB@??C>=D>?8?>;CCBFC4@<:?AE?EAC4FGE4@FD@@GFF?@B=C>FFFBE?DFCGAEAAC4FDFFGCABB6<>E6DA>>EEBB?C@CCAFD;AAGFEEF@FBFGCEFD?E?CD:?@=>>DD5?C=;DGEEE291@7C>F@CCB@;DCGFBB6A=FD?AA>B>A>E@A9BCCCD:?D3@D<@B.DBEDB@:E?EABEDEEFE?DC:FEC@AAEABFEB9=FGCB@C>:C=ACEDEEDDB6GD@8@GC4E>A?BB4BFACGEDD,DFECDE49EEBD/8;:B&A @rCer/1064/1505_74_CCS GAGACAAGAAGCTCCCAGCCAACATCAGCGGGATGCGGAAGGAAGGCGAAGGTGTCTGAGATGAGGACAAGCGACTTTGATGAGATTGACGATGGACTGCAAGCTTCCTCAATTGGGCGGCAATGCATCCACCAAATCGAAAGCGTGTAAGAAAAACATTTGCTAGAGGAAACCTGGATTCACCTCAGTCAAGGAAGTCGATAAGGATCGGACTGTCAGAGGACCCCAAGGACTTCTCCGTCTCCACACTGTCCCCCATCTGGAAAGCTCGGACGCCAAGAGCAAGGCTGAAGAGGACGTGGGAGTCGTGAGGCGAGGATGCCAGGGGCCACGCAGACGCAACACGCGGCGCCTCCGTAGCGTGGGAAAGGCTTCTCCAGGCGCTCAAGAAGAGAGGCAGCAAGCTGAAAGAAGGCAGGGCCAGTATGGACGGAAGGGGAGATGAGGGCCAGGATCCCCGGGATGTCAGAGCCCGAGGGCGACCCGGCAGAAGAAAGACCATGAAGCGTGTCCCGTGCCCTCTGGCTGACCTGACGGTGAAGTACACACAAAGTCCGTTGCGCCACCACGACATCAGAGATGGAGGCCGAGATGTCCACGTGGCAGGTGTCCGTCCTTCAAGCGGAGACACAGTGCCCACCAGATTATGTTGCAGCAGAAGCCGTGCGCGAGTACTTGGCTTCAACCAGCAGCCAGCTCTCCCGCAATCTACCCTCCTCCCATACCGCGTGGGACTCCAGCAACTACAAACCCTCAGCCCATTCTGGAATGGCCGGCATGCCAAATGGTTGCCCTGAACTACCAGTCAGAGGCGCGATGCTGGAAGCTCAACCGAGCCAAGTTCAGCGCCAACGGTGGCTCGGCTAACGTACTCAAGCGCCGATGATGCATGTGCCTAGGGTGTGTTCAACCCCAACTCGGAGGATCACCCCCTGTGTCCCGCTTTGGCACCATGCCTCCCACTCCTGCCCCGCGTCCCAGGGGGACGGACAGCTGAAGCGCCGCTGGGGGCCCACAGGGAGGGGTCGAGGCTGGTGCCTCGCCAGGCAGGAATTTTCCGGGTTGTTTTAGGATCGGATCCCATCCCAGAAATATTTTAAATTTTTAGAAGCAAAACTTATAACATTAAATGATACCAAGTCCCTTTCCATTTTACACCTGGCTTTTCGCCCGGGTGATGTTGTGGTGATGCATCTGTGCACACCGTGTCCTGAGCCTGCCCTGGGAGAATGTCAGCTGACCTGGCAACGGCACAAGAGCTGGGGTGCGTTCGTAGAGGCACCAGGCTGCTCAGGATGCTCCTGGGCCTCGCCATTGAAGGCTGCATCTGCCTTGCGCGGACCTAGCTGCCCTTTCTGCACCAGGCCTAAGCCTCTGTAAACTCCCGAACGGTGTTCCACTAAACGTGTCACCAGCACTGCACGGGCAATT + #"$,%),..,//*+,,,/,.,,//-+.+--*%.&.'-$#--).-.+--.%.).-./..,-.)+.-&+-,-/..#+,#',./-)&..)..-.,,+(..*,.,-.$-%----.-$%,)&"*'#&#*."/*+-..-(#-+...'+/-/,..",#&)**--.)((/-.-./.).),,#"*$--).#-+-.%#'.--(%&,,-..""/-+)..-#$--..-"",-#(-,*)*+-"+../*..+./.%/-+.,.//%--+()+/+%/.+/*-/-.,.*-.++",-./.),-/*../+-..-(../..)#,#',")*##+-..-*.'.*+#-'$)+..#/...--..--##-."+).)+.."-..$#..)-+'.*.#(..*-.,./)+.."%-,.+.,-/-"-)+//.)....//+$.&-.(.##,*(-//#.,.*.".)#.-'%'..-./,-+(+../+//-+)*%'&&#.-,/./*%*,..-+(-.&)),%+,/---./)-...--/-/-.."..##*+'-&%,+...%!/.//*../,#",...*.-/...#.-$"'---.%(.",*./.-//..//."/.-.//-*.-**#/#.//$,../$/..*,,,*-(,".%.-,.%+.#+."+$,--%"-.#-(+)..---,'%$."-*-(#---.-).'+)##'$$",..+-,%/+-/),-,)('...")-*.)*-."'-...#/---')&%'',$,+$(+.-.-/..+&...*,(.'*-../.-+".,+.-*/*-&#-*+..*--,.#++.)$#..*-*+-.++.)&)-,.&&+.&.--)//.+..,*.,).../(.#,#.//./--.)/.-,-,.-.))/.-/,.-.-.,./,..+/+,..&#/./,.---/./,///".&//.-/./.+.#..%),./.,).--.'*#--/*./+*.*/""**)'&*....+*++$*.'$.',",+$..#/.,,*#-.-../&'+,/,#.+,,$&*&%#-$,%%"+-.-..,+#,),%&%,%%'&)('#&.'&*-)%-*.-//.+.,/+""*-"-.+...*..#+',.)"+,)#,**$'.(,,.-#//+%-/.#,,--)*%+/.*...-$+,-',-$*',../-).,*,-*/*..&).,,*-+'/.%#"-,,./.*),.)*),-%+*$,-"'-.*++-)++..)((-%*&+#-+#%*+.*--#..&%.-./..(,(,.-%..-&..-.-+-.*),%'.+'.)%./."..//./..$(.(,#%..&,-..#/-.+--&)(-.-".*#.,"...)..--/*+.+/../..+'//---)-*+%+..-.+(%+(./-/+.-/.//../'-(%.-,,,'&,-,"/--.#(("$(+..-..-//*),..,/+-.,,,.-*-..*,*/,+.%&#--(**-#.)).(..././.$..,.#&.#...,'+-+.# @rCer/1067/1620_58_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATTAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCTTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGT + >8<<%7456>=>7/8<=18:16;7<<8<673170:9'6==7<=/===4:3>:<077<:5:2?9/5<0>506:?=A;@C?;<>;:;B>66@9><:9?;9=C?3@;????C?>?9?;@@:7,>78C7B?7A@A;66+7@C?>:B>;6>11=31:1??;@@;@:5>:::B@>7<>8B@9;,>=96>@=/>:>=?CC=;57,<<5AA?@)<5BA=B6=4?=?9;==;?;<:@9;?<:CBCCCA5;B<3B?1A:?8??(6>8>753570%35=?;79%*/06<@;>@25><<7AA;@AB?A?A?2A:@:@;A?>C9<:9-5:=(:?8>4@?B775;1?>>?;?><@0:7<;:2C;-3>@A+=5>C:74>:>3A282@;:649?=5@>BA6+;<;6:B=C:@=3;:;:7CA=<<=7'34809:095==:05=>?>1@@:>>A8B>@;8:6=4?:>.A..=@;*5>>=<88=7A;B@7;68@4>3@A6;A9A@=;:/99;BA;@><77@3?@98..2B:A@7@A97:@3=4=A<>4>4;9864431;9A5=>A8=B@?9:BC6;6>73>;;?7;<>=9:5;>==:??<>9+<6>@A5=<>A8A<>;6=;9>><,BC4B?A:>8B@?AB5C=<=7C?@=6@=6;=,BB9@:=3=<9?90?45>;;9;><2@9?84=?;A9@6A8CC?>=@/8A=?A?,<9=AA6?@C>?>=?/8?C;:A>C?64;<6?B<6=8:-1;25:<<.-@A?:C8BA9AA?<=6>A<;:8-:925075>@=?AA4@AC>>C>C>6?9;BBA@9093B@@>4>@?87AA@:BBCFDECC,BBDC;?B@@3?CFDBBEGDGGEAC@3>DEE5FB6EE4AE?CE7B@>9D@@DC@GGDEE8C2AFB59A@;>AFDDA8E8,CCC;EFE@FCE@F;A?EFFE7EA8@E@E@FACBG@FACDE@E<=E@D?;;><@?$A>;A7=BE;GCA;D:@CE?>@DFGD<8?A=(@CEF?@CF@;76>;FFEFE;F@3C?CCB6?FDF>BD8AE5EEC4EC5EGFE;F@BE>B=D=BFCECEA8<>3@DEBE?;=D>ECD78=DCB3@AGBD?C3A<86DBG:CD@FG@:D7=E;CC@;EE@DEA@>@A8ED=@+ADAE:AC6<=5@>EEECCAA>4?7>FFFEEECCA<38>A>AFDG>AF:2EA:D>@CD:;C@DDGEE@E@3<@DE8DBCG:FA9>FCDG8B;8C@0B@EFBC@AAD>@=?D6EFGFD:0?:73:;6BFE@FEBACDAEEED?BKKKKK2KKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKDHKKKDKKEKKKKKKAK0KKKKK@KKKKKDKKK0KK/KKKKKKKK(KKKKJKKHKKIKKKKK,KKK?KKKKKKKKKKKJIK%KIKKEKKK'KKKKKJKKK*KKKK4KKKKKKHKHKKKGKKJJKKKKKKKKKKKKKKJKKKKJKKKKKKK5JKKKKKKKKKEKKKKKKIKKKKKKKKKKKKKKKKKKKK>KKDKKK1KHK7KGKIKKK:KKJKKKKKKK1K0KKJKKKKKIJJK1KKDJJKKHKKKKK4KIKKKKK9JK2KEKFKJKKKKKK+KKKKKIK1KKKKKKKKKKKK+KKJKKH@HIJJKKK=KKKHKGHK@KGGKKKKHJKKKKJKJKKKKK7JKKKJFHJJGIKGKHH?KFKJKKKKKKIHGK;KKJKK@KKKJKKKKKKBKDKECBJJKB/KKFKIKCK@JKI6KKFIKCKGFKKKKKJKKGKHFKCKJIKEKHKKKKJIKGKKJIJJKHKKIKKJKJKJJJKJJHGHHKKKKKKKKGKJJK=KK0KKKKGHKK8KKKJJKKKKJKKKJIHKKKJKEKCKKKKIKJJKKKKKKJKKJKKKKKKKKKKKKKKKKKKJJ8KKKKKJKJKKJKGK:JK)KKKKKK5KK6JHKKJKKKFKKKKIKKKGKKFEKJKKKKKKKKJKIJKKKJIKIKKKKJIKJKGKKJIIIJIKEIKBI@HJKKHHKKJKJ4IJIKEKJKJK>JJJFIEHI=KKJJIKKKJKKKIK7KAKKHE:JIKGKBKKKKCHIJKKJKJGGKKKJKKAKDIKKDKKKKCKKFGKKEKHKKI>C8HCJJJ3KFKK?KD3EHDKJJKI0KK94KKKKKBKKJ7D3FIKHEBGI7JIGKKKJKKJHK6JKKKJC=JJCIEGJKG?DKKJKJKKBKKIKKEJJJKKIKHJJKHKKK4KKKKKKKJFJHJKKKDKK7KJKK2KKGDI8HG9>JKJH84KEHJ6IK3@6G?AEKJCKJHICKGIHH;IHJ@JIKKKJKFHKGKAIBGJKKKKEKIFGGBH>GJKDGGFHB9IJJFH>KKKKIH>JK?KKKEKKKKKKKAJ2JGGCDGKDJ=KIEJGBED8;JCKK:JJJDHIJKKKK?KKJIKK9KHC@JCJKE(EJKG=8JKJEF7@DJAGIHGEKKG7HKJH=KKKJHJIKEKKHFIDJI>FI?KJKKKKKBKKKKKIBIEHJKKHKHIKJJKEJJ2JJKKCJIKKKJJBI@JJKIJK+KKKKGEEE>J=CIKKI;KKHIK?IKJJKICHKKJHICFIKJJKKJFEIG@AHHAFIFJK?GGI@EKGG=JCDDKIKKEKGJIIJKHK=HKGHHKKKJJKJAKJFJEJ3HIHHKJHJKBJIJ=JGHKK8DJJKKKKKKJJJKGKEKKJKKGKK8KKKHH4KKJGJJJCKKKKDKI@GIII83IKJKK3J?KKKK4K9IKJKJKKAKJKJIKKKK?JIKKKKKIKKAJKIKIFGH6KDJHAKKKIJKJHKIKIGKGKG5HKGFFJI?CKKJFGAKKIKHKIKJH5IKKFKIGHBKKKK?KKGKGIKKKJKHHAKKHIGKK8KCC:DKHKJI=KKKK=E2DKIBA>E>5KFKJ.9EAHC>KJ @rCer/1073/25_2080_CCS ATGGGCCCAGATGTCATTAGGGCTCAAACCAAAAGCATGCACTGTTCCTGAGGAAAGGTGGGTGATTAGGCCTGGAAAAAGGGTCACTGGACTATAGGAAGAGGATTGTTTAATCCTTTAAACATGCATTAACATCAAGGAAAATCTATTAATACTTGTTAATCACTTCACAGCCTACAGTGTTTCAGTACAGGAAAGTGAAATTACATACTTGAACTGATCCTGTAGGTAGGATTATAGTGAGTATATGGTGATTAAAAGGGGAGACTTTTAGACAGATCATAGGAGAACAAAAAAAAAGAGGGAGGCTGCCAGAAACAAGAAAAGAGATTCAGTTTAGACAACCTTTCCCCTTGATCATAGCAGCAGAAAAGCAAAGCAAAGCAAACCCCCCAGTTATAGACAAATGCTGATGACATGGAACTGATCCCTGACCCTGTGTCAGAGGGGAACTTACTACCATTTCATCACATCACATTTCATCCTTACCATTTTCATCATCACAAACATCATACCATTTAATATGTTTACTCAATTGATCCCATGCACATAATGTGATTCTACGTCTCACATTATAAAACAATGACAGCACGCTTCAACTATCCAGAGCCTGTGGCTAAACAGAACTATATTTTGGTATTTAAAAGTTTAGAGGCAAGAATAAATAAAAAGAAAATAAGTGGATAGCAAGGTTTTATTAGAGTAGAAAAAAAACAGATAATATGGCAAAATGGGCACAGATAAATTTAATCTATGCTTTCTACAGCTACTGTTACTTACAATAAATACTGGTGATTCCATCAGCACTAATATAACTTTCTGTGATGATGATGTTCTAATTCTGTGCTGTTTAGTGCAACAGCCACTAGCGACACACTGCTACTGAGTTCATGAAATGTAGCTAGTACAACTCAGGAACTGAAATTTTTGTTGTTATGTAATTTTAGTTAATTTAATAGGGCAGATAATAAAGATAATCATTCTTTTAAAACAAAATATTTTTTTTTGAGTACACTGTGTCAATAATATAAAACAGTAAAAGATACTAAGCATTTCAGAAAGGACCTCAAGGGAAATGCTTTTTAAAAAAGTTTCTGGGGCCAGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAAGCGGATGGATCATGAGGTCAGGAGATCGAGACCACCCTGGCTAACCCGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGTGCCTATAGTCCCAGCTACTTGAGAGGCTGAGGCAGGAGAATGGCATGAATCCGGGAGGTAGAGGTTGCAGTGAGCTGAGATGGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAACCAAAAAAATTATTCCAGTTAATTCATATGTCAGGTAATGTTAGGAAATAGTGTTAAAAAATATAGAATAGCCTTCATTCTACTATATATTGTTAAGAGTGTGTACATATGTAAAGCTATACATATGCATATACTCTATTATCAAGCATTTTATTTGTTGCTATCATCTCAACACTGGCAACTGTTAACATTTTTTATCTGTGATATTTCAAATGTTTTAAGTCAATCTTACAGAAAAATGTTATTTTGTTACTGATTTGTTGGGAAGTTAAAGAGCGAGGTTGCCCCAGGGAGGAAACTCAGTGAAAAAAATAGAGAAAATGAGGGCCCAATTCAGTCAAAATGGAAGCATCAGCTCCACGCAATACAACTCAGAAAAAGGAGCAACCAAGCCGGGCACGGTGGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACGGGTCAGGAGTTCGAGACCCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACTTGTAATCCCAGCTACTCAGGAGGCTGAGCTGGAGAACTGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGCGAGAGAGTGAGATTCCGGTC + ,.*01$,,-0110'.0,+/-1-/10,00/.&-../-0,-.2266544600//635604/264546664173661:%346424869:18:;66768:392:44(+3588%771928;399/:415880969%49568:;:949;:/896/558899:9:/66:1479484234215.456535*541455:6:955::49:2820:9501.,467::156:454271356466751502./8:966853//385649.652141476944:;;:409:812475599:54;9,:8889414387845898145;:6,67570359:594:954%8757699676994166-::88;:4731265768442)56435564:61977.)99/8:874154.36/,848:9:8:9779858:687/57:798:;;:9::9;77183/59:.86/,749:5.5:7976:88:::4928873'66;92,06&-+)2-%,-.15:::68599;8544842339929:7;6778$28878:/8.87:8'888:42175115508:58;:77,.,0)249:9:53*+475387:3,303544517545*111489:64399597;89.779913994125'1221671365)2224*641334524671142152'/5440'/72.8:278651/8:57,1,:;7(*62320%25%2./01025547404.11269+8711.662::5:8::7;33:588692699+84484456:9249616634665794+8957670:41)02099/98:/559-3594/,'14727:5734486:3783423.45330/53/34(1/03333:;:553993&,+20/3325431()(221236;:8095:158435199::6:.878584:599::67:448888466-643768;7;;;9//55:,874914457::532:;949766:579:7+30)16406831&.4020$344320122'+/4565(3351132833483+:957466-85725446833374*34454.77497245556044408*54378:4-66778726522*99545733,6211/222/511-1264+/34+51,**.0,/6/50.05+307747565241/06-)321016445+1,454)*4.5244.76812483764666+522445365616311'352/145%24213379384487+.).//.+).264235103.,4+711445,5.7714635(35436/10/05682665/8116615-524.6017588/520163727766551/*,+&-36763600%0642.15.41,--/'%,.2-/1222*11/03,026789:81*%1023-/-52/259269:197:19239:6:3270124319137+663(/+0+2$.577798::459&+54:.:9:/736880/12&)'1029.871113+4/12/2.7730115.*13335163,*3413658992-73/4)1./3%-/,+(8540957315674589,-5568-:32416658/455)/880378623067305635-45443358847776668676726.4487885/3.577/&40993:539:276;;:999;(85898513::/:2)22/*'*+&(,(//**0.+,*$--/.)'-0453*000/-)',0*,/-0002/1.0$.*.0*0)/0/,./02/+)*&,/*)/(00*1/3/*-**,21/,'.51213$,)$((+)%(/(+-'+,.-..,%,0/-'**+..//++,++1+0/)%$+11,&+,.2.//.*$&%*&')),,-0111211-'-%.-)..2.1+02-0-0110,.$0/+00-11,/11.*/022-1',1.2201)0,//..(--/+/2101--()--)+,--),,'--,)%''*'*((,*,,,)-+&+(#&'))(,-+,*--+.)--,.-*-.+'-+,-(+++'(,,-*-*-,)').,-,''$((+-----.--,,-,*.--*,-,),,,(++#)',(,+, @rCer/1074/25_1565_CCS ATGGGGGAGGGCGCGCGGACCCCGCACTGGCGCCGGAGCCGGTATGGGCCCGCCCGGCCCTGGGCTCCGAGCCGGACGAGCACCAGCCTAGAGCCAGGACTGAAGCTTCAAGATGGCTGAGCAAGACCTTGGGGGTATCAGCTCCCTCCAGCAAATGGTGGCCTCAGGCGCTGGGGCTGTGGTCACCTCCCTCTTCATGACACCCCTGGACGTGGTGAAGGTTCGTCTGCAGTCTCAGCGGCCCTCCATGGCCAGCGAGCTGACGCCTTCCTCCAGACTGTGGAGCCTCTCCTATACCAAATGGAAGTGCCTCCTGTACTGCAATGGTGTCCTGGAGCCCCTGTACCTGTGCCCAAATGGTGCCCGCTGTGCCACCTGGTTTCAAGACCCTACCCGTTTCACTGGCACCATGGACGCCTTCGTGAAGATCGTGAGGCATGAGGGCACCAGGACCCTCTGGAGCGGCCTCCCCGCCACCCTGGTGATGACTGTGCCAGCTACCGCCATCTACTTCACTGCCTACGACCAACTCAAGGCCTTCCTATGTGGTCGAGCCCTGACCTCTGACCTCTACGCACCCATGGTGGCTGGCGCTCTGGCCCGCTTGGGCACCGTGACTGTGGTCAGCCCCCTGGAGCTTATGCGGACAAAGCTGCAGGCTCGGCATGTGTCGTACCGGGAGCTGGGTGCCTGTGTTCGAGCTGCGGTGGCTCAGGGTGGCTGGCGCTCACTGTGGCTGGGCTGGGGCCCCACTGCCCTTCGAGATGTGCCCTTCTCAGCCCTGTACTGGTTCAACTATGAGCTGGTGAAGAGCTGGCTGAATGGACTCAGGCCGAAGGACCAGACTTCTGTGGGCATGAGCTTTGTGGCTGGTGGCATCTCAGGGACGGTGGCTGCAGTGCTGACTCTACCCTTTGATGTGGTGAAGACCCAACGCCAGGTCGCGCTGGGAGCAATGGAGGCTGTGAGAGTGAGCCCCCTGCATGTGAGCTCCACCTGGCTGCTGCTGCGGAGGATCCGCGCCGAGTCTGGCACCAAGGGACTCTTTGCAGGCTTCCTTCCTCGGATCATCAAGGCTGCCCCCTCCTGCGCCATCATGATCAGCACCTACGAGTTTGGCAAAAGCTTCTTCCAGAGGCTGAACCAGGACCGGCTTCTGGGCAGCTGAAAGGGGCATGGAGGCAAGGACCCCGTCTCTCCCATGGATGGGGAGAGGGCAGGAGGATACCCAGCCAAGTGCCTTTTTCTCAGCACTGAGGGAGGGGGCTTGTTTCCCTTCCCTGCTAGCGACAAGCTCCAGGGCAGGGCTGTCCCTCTGGGCGGCCCAGCCCTTCCTCAGACGCAACTTCTTCCTGCTGCTCCAATCGTGGGGATCATCACTTTCCCACCCCCCAAGTTCAAGACCAAATCTTCCAGCTGCCCCCTTCGTGTTGCCCTGTGTTTGCTGTAGCTGGGCCTGTCTCCGGAAACCGAGAAACCCTCAGCCTGGCATAGTCTCCCTGACCCCTGTTCATTCCTTAAGTGTAAAGATGATGAACTT + IKBKKKKK5KKKKKKKKKK.KKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKJJKKKKKKKKKKKKKKKKKKKJKKKKEKKKKKKJKKJIKKKKKKEKKKKKKKKKGKKKKK?KKKK@KKKKIKKKKKKJBKKKKKKKKJKKJKKKKKKKKKKAKKKKKHKKKKKKKKKKKKGKIIKKKKKKKKKKKKKBKIKEJKKKKKKKKKKKKK+KKKKJKKKKKKKKKKKKKKJKKIFFGKKKGKHIKKJKKKKKKKJKGKKKKKKKIKKKKKKKKEKKKKKJKFFKCHK;KKKKKJKKJKKKKKKKHHKKKKKKKKKKKKKKKKKKKKJKKKKKKHFKKKKKHJKKKKKKKKKKKKKJKKKKJKKKKFJKGKKKFKKKKKKIFJKKKJKKKAKJKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKGKKKKKKJKKKKKKKKKKGKKKK@KKKKJKKCKKKFKKJKKKKKKKKKKKKKKEJBKGKKJKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKI8KKKKKKKKKKKKKKKKKKKJKKKKKKKKIKKKKJJKKKKKJKKIKJKKK9KKKKKKKKKKKKKJKKKKKJKKKKKKJKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKJJKKKKKKKKKKKKKKJIJKKKKJKKKKKKKKKKKKKKKKKKKKKCKKKJKKKKKJK@KKKKKKKKKKKKKIKKKKKKKKK=KKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKHKKKKKKK@KKKKKKKKKDKJKKKKJKKIKKKKKKHKKFKKKKKKKKKKKKKJKKKJKKKKKKKHKKHKK@KKJKJKKKKKGKKHHEKKJKKKJKKKKKKKIKKK>KKKKKIGKKKKKKKKKKK2KKKKK>KKKKKKKKKKKKKKKKKKKI:JKKKKKKKKKKKKKKKKKKKKK@KJKKKJKJKAH7JKFKKKJKKIKKKKHEKKKKKKKHKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKJKKKKKJ0HKKKKKKKKKKKKKKKKKKKKHKKKEKKKKKIIKIKKKKK,KKKKKKKKKKKKKKKKKKKK0KKKKKKKJKJKKFKKKFKKKKKKJK>IK+KKKKKKKKKKKKJKJKKBKKKKKKKKJKKKKKKKKKHKKKKKKKKKKKFKK9FE?KJKIKKKKKKKKKKKEKKKKKIKKKKKKKKKKKKKBKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKJFKKHKKKKHIKKKKKJKKKKK+KKKJKJKKKKJKKGKKKKKKKKJKKEKKJKK@KKKKKKKKKKKKFKKKKK/KKKKKKKKKKKKKKKKKK'KKKKKKKKHKKKKKKKKFKKKKKKBKKKKKK=KKKKKKKKKKIKK=KKKKKKKKKKKKKKKKKK=KKKKKKKKKKKKKIKKJKKKK2KKBKKKKKKKKJ=IKKKKKKKKKKKKKKIKKKKKJKKKKIKKKKKKKKKKKKKKKKKKKKKKKKK @rCer/1076/2148_57_CCS ATGGGGGGGCTCGCGCGGCGGGAGCGGCAGAGCGGAGAGGTGGGCTAGGGGCTGGAGGACAGGTTTGTGCGCTGGACGCAAGCCGCAGACGCAGCCTTGCTCACCGAGAACCGGCCAGAGACAGGGTTTCACCGTGTTGGCAGGCTGGTCTCAAACTCCTGACCTCAGGTAATCCACCCGCTTGCCTTCCAGAGTGCTGGATTACCAGATGTGAGCCACCGTGCCTGGCCGACCCATCTTCTAAGAGTCGAATCTGTCTGTGTTGTGTTTACCTTTCTTGCTCTCCAAGAACGTGTTACGAGTCAGTTTTTAGTGAAAAAACATTGGACTAGGAGCCAAGACCCATCTCTTCACTATTTGGTATTGTGCAAGTCATTTATCTCTCCGGACCTCAGTTGTCTCATCTCTAAAAGGAGATAAAAATTATTTACCTGCCTGAACATGAGGTGAGGACATCTGCTACAGTATTGCTTTCTCTTGATTACATGTCTACTTACTGCTCTGAAGCTGTGCCTATAGACGTAGACAAGACAAAGTACAAAATATTCACCTGTGAAAGTGCAAAGATAGAACCACCAGATACTGACTTTTTATGATAATATCTCAAGCAAGTGATGATGTGCTGGAAACAGATAAACACTCAGAGAAAAGCTCCAGAAAGCAGACATAGAGGAAATAAAGAGTGGAGCTAAGCAAAGAACTGGATTTAGTAAGTCACCATGTGAGGACAAAACTTGATGAACTGAAAAGGCAAGAGTAGGAAGGTTAAGAATGTTAATTAAAGCTAAGTTGGATTCCCTTCAAGATATAGGCATGGACCACCAAGCTCTTCTAAAACAATTTGATCACCTAAACCACCTGAATCCTGACAAGTTTGAATCACAGATTTAGATATGCTAATCAAAGCGGCAACAAGTGATCTGAAAACTATGACAAGACTCGACATGAGAATTTAAAAATATGAATGATGAAGGAACATGAAAGGAGAGAATATTTAAAAACATTGAATGAAGAAAAGAGAAAGAAGAAGAGTCTAAATTTGAAGAAATGAAGAAAAGCATGAAAATCACCTAAAGTTAATCATCCAGGAAGCAAAGATCAACTAAAAGAGGTATGGAAGAGACTGATGGATTGGATCTAAATACTTTGACCCAAGACATTTTTCAAATTACATGATGTTAATAGTGTGGATTCCTGATGAGCAAGAATTAGAAGCCCTATTACTAAAGAGTTGGAGAAAGTATATGACCCTAAAATGAAGAGGATGATATGGTAGAAATGGAAGAAGAAAGCTTAGATGAGGGAACATGTAATGAATGAGGTTGTACTAACAAAGACAGATGGTGACTGGAGGAGTTTTGAAAGCCACAGAAAAAAAGATTCTTGGAGCAGATAGCTGGAGACATTAGATCAGCAACAGTTCTTCACAGAGGAAGAACTAAAGAATATGAAAATATTATTGCTTTACAAGAAAATGAACTTAAGAAGAAGCAGATGAGCTCAGAACAAAAAGAAGAGCTACAACGTCAGCATGATCAACTGGAGGCTCAGAGCTGGAATATCATCAGGTCATACAGCAGATGGAACAAAAAAATTACAACAAGGAATTCCTCCATCAGGCCAGCTGGAGAATTGAAGTTTGAGCCACACATTAAAGTCTGAAGTCCACCAGAGCTCGGAAGAAAGCTGTTAACTCAACATCTATTTATCTTTTTAGCTCCCTTCCTTTTTCTCTGCTCAATAAATATTTTAAAAGCATATTTGAAATAAAGGAAGATACTTTTTAAATGAAAACACTTTTTTGGGACACAGATATTAAAGGATTGAAGTCTATCAGAACCAGGAAGAAAACAAACTCACTGTCTGCTCTCTGCTGTCACATTCACACGTCTCTTCTATTTTTTTTTTTTTTTGTTCTCCTTTAGTGATTTAATTAAGTGCTTTATGCATAATTTAGTGAAACTATTAGGAGCTATTTAAGTGAGAAACTCTGCTCTTGCTTTTAAATTAGATTGCTCTCACTCATAAACGTAGATATTCTTTTATGGTGCTTATCATTCTTCAATAAATATTCTTTGATATAACAATTCT + 1..*(+*(#0,/2432/*033//$)/'2.34544/31)54440'&10211(25))0,$*-+6044)/1355+2610)450'26150364.3/.2404/52252211356.)#-(&*.151*1140--.&202,-0/0,0,%12'+0312555661--/,0,(+)0026451*-4/411+.$')#*+1*2*/-30111,1)(*)-1/+220/3-543%-5)10560212100134*52031221&.0.-/--+0)325102545,2.2362/401...3$33,2*,(0.03)14403&/2535224*5/15)540045554*3--'3,534.50+&,'0))366.2222/-+-525433)/(556,*20562420/***/1///.3()#23*13023564*4462313,///(54101.01/2'2152605122.4/042+0/1)42*1%-4-(.0,%.40.4.53545)54651'1/5+/.4+10/51*/-0/2122)./52$+644342//0(+.23530+2231/3.42025('3454/2*/13*0,2'41/&25-252266222,*6615+3551,0'55.#,350#-+0/14#*.3./435600(/')..&$15433/3*4/54,24515220030$45243251,1,45+3,66205/)10241+31-42)553,00,,0+.$./415566056312.%3660-.43)1.5/6//4.4*)3*0.322$1653541646641+2(1*/0*.%#2-40501'3-21165+'/(103,14)2//4.43-3(20)55)4)42+0'00/43/40).&2/'./*0)54-45,51440,25+12*3253100211&/(5212-/,21+511-4+$66.5510#260/5251/*400/-514011260.30)*6555))211*0-)/44*0.21%./-'..&/515553/$)1.6105255+430'1%.4110.,.)2/12+(14'6/)/-)2(*012%/,20#12234415/6/),30$35%/1(.6-*0()4242(34*10*45,33-%)2640606/0.352-+1%+*(0%/64.0-*-*+0000%32+0)553/')-,+4-15440'-+,'6241%(/33/3+564560/4-2++*)(#%&#*.04*5166361432.5654)131.61/113+2111%2(.32.%0/,.32)((%,2-+*34020(3/..2((54&033'-5265,02)3(*/1-*/$4451/.(,44//10/$-/4%,4,/1*$,)2.2++-*//(31)62.1/562,&&**."$35211%1,(/-.(-+56653456/3.$356560163014/('4&(-62%&#*+03)1'453$466146/555330/2-0(&$-.04(4(4,/2(*4-2//2&*,.114-0*.2...(1).,/4..3))+115560422605321%*+%/,03644.016521,1134)4150/455+53624606201))2.'102/0+3%.$3402#23635-0-&+)0/)315.+4441/.+5213142+1612+$*.321#-522..+*'11112(((3,438::892*14:3:40367632$0.123-)3-5+4.916587/968/0&++1/06645/8(/.578588'0+%1&624636-37+570&+3%,40'51'20733'3:59)335'20036'6-3<,;))798=:;='348<=;:/<>;;77%=54%<=63*1449:;<;>7>=?6=:68:-===)9;>;<;=/,?767994<1906252/6:67&78.&6;=?300038<>2):6415200317:>/?;::;<7951:>?57*766;:79;9/399'01;>>;7:882,.6<069<<,=::7?C><1590303=?=;>=:5974=97=;=1/;8$-?.8<;1C>55?03589)?4C??=:65?=/3=58%%;2)>=/2260;:4=76<.5:&94.A;;>65(245829;$:8878'2834:5:=?524(:04/6:25/10405.45676:-95.7/6505-,421%/.5'1259565574..8,270793)7/4,29:51163%0/6833597 @rCer/1077/1913_60_CCS ATGGGGGGGGACTAAGGCGTCGGTTGGCGCGCAACGGGTTCTAGGCTGCAGGCAGCGCGAGGACCCGCGGCCCCGCCCCGGCTCGGCCTGGCAGGTAGCAGAGGCAGCAGGCCGTGCCGGGGGGCATGTTGCTGTAACCAGTGGTCCAGGGGATGTTACGGTGGACAGTGCACCTGGAGGGCGGGCCCCGCAGGGTGAACCATGCTGCAGTGGCTGTCGGGCATCGGGTATACTCCTTCGGGGTTACTGCTCTGGTGAAGACTATGAGACGCTGCGTCAGATAGATGTGCACATTTTCAATGCAGTGTCCTTGCGTTGGACAAAGCTGCCCCCGGTGAAGTCTGCCATCCGTGGGCAAGCTCCTGTCGTACCCTACATGCGCTATGGACACTCAACCGTCCTCATTGACGACACGGTCCTCCTTTGGGGCGGGCGGAATGACACCGAAGGGGCCTGCAATGTGCTGTATGCCTTTGACGTCAATACTCACAAGTGGTTCACACCCCGAGTGTCAGGGACAGTTCCTGGGGCCCGGGATGGACATTCGGCCTGTGTCCTAGGCAAGATCATGTACATTTTCGGGGGCTACGAGCAGCAGGCGGACTGCTTTTCCAATGACATTCACAAGCTAGATACCAGCACCATGACATGGACTCTTATCTGTACAAAGGGCAACCCTGCACGCTGGAGGGACTTCCACTCAGCCACAATGCTGGGAAGTCACATGTACGTCTTTGGGGGCCGTGCCGACCGCTTTGGGCCATTCCATTCCAACAATGAGATTTACTGCAACCGCATTCGAGTCTTTGACACCAGAACTGAGGCTTGGCTGGACTGTCCCCCGACTCCAGTGCTGCCTGAGGGGCGCCGGAGCCACTCGGCCTTTGGCTACAATGGGGAGCTGTACATCTTTGGTGGCTATAATGCAAGGCTGAACCGGCACTTCCATGACCTCTGGAAGTTTAATCCTGTGTCCTTTACCTGGAAAAAGATTGAACCGAAGGGGAAGGGGCCATGTCCCCGCCGGCGCCAGTGCTGCTGTATTGTTGGTGACAAGATTGTCCTCTTTGGGGGTACCAGTCCATCTCCTGAGGAAGGCCTGGGAGATGAATTTGACCTCATAGATCATTCTGACTTACACATTTTGGACTTTAGCCCTAGTCTGAAGACTCTGTGCAAACTGGCCGTGATTCAATATAACCTAGACCAGTCCTGTTTGCCTCATGACATCAGGTGGGAGCTGAATGCCATGACCACCAACAGCAATATAAGTCGCCCCATCGTCTCCTCCCATGGGTAGGAGGAAAGTTTCTGCCACCTCCCCTCCTGAGCCTGCTGTCACCTTCACTGCCCCTGCCCATCTGTCACCCACCTGCGCCTTTGACCCCTGGACTTGGTATACCTCCATGTGGAGTTGTTGGGCGAGAGGTGTTCTCTGTGCTGTGAATTCAGTGGGGAGCTGTAGCGGGGTGGGGGCCAGGTTCCTCCCCCCTTGGGCCGAGGGCCCCTTCCCCTTGGTGCTCTGTCCCCATCCACCTCCTTTCAGCTGCTCCTGGGCCTCAGCTCTGCCCAGGGCCAGCCAGGTTCTGTTGGGAAGGGAAGGGAATGGGAGAAGGGAGAAGCAAGCAGTGTCTGAGCCTCAGGAGCTTCCCCCTCCCCCTTTGCCTATCCCGTCCCCCTGCTTGAGCCTTGAGCCTTGACTGGGAGCTGAAAGGAGTTGCAGCTGTTGGCATGAGACCTCCTTCTCCCCGTCTTGGGGAGGCGGGGACCAGCAGATAATCCCATCCTTCCTTGAGCTGTCGCTGTACCCTGAAGCTCAGCCAGCTCAGATTTTATAAAAATTAATTAAAACC + HJ>GDEE)KJDBIH>I<3CGI3IJIEHIK;JKJJ:JIDJJKHK@JIEJAJ=BDJJII?KCGHBD@J5FBKJI>6I@HAA0EEDFJ@9KEIIFDDGK?GHEHKGJEKGIJIJI3KJHJEB'C6<AFIIEKKK>GKEJFGIIKCJ@AH8EFF7FCBDGI,HEBGJJKDKD44CHGBG>G@CFBKGGGEKIDAKIJGKGF@?<9G6I=ABCG4DGED)H>HABD>F>DDF@CI=>1I@BGGBDDHEAH8CHDDAGBHF@@H@EF/DIIBJF<>C=E?C@D>=H;I6@AIFHIFDEHJJH0ICF:GC=<(DD>BA7FCBIE=7EBFFDAC>F>?AHEHCGACGBF;F>AIEIB>CB3;?>>:@;@@=9DC>;:@D<=7?CB8CB?A9B:??5IDEAE?DFIH@I?BIHCI=>EGJHF5HDA>D9FI=C?CEHH6B5BBDE=;AE2B0?<>C:?695A<8;5%647@A?3BB8A@B?BB=AAC=>B>D3=@AB9=CAD,F;>BEE?F9EHC=>*?@FHC=6<6969<4<@D=D8G?6F?DBFHHG?FJ=GCHGBCHHDFHJHHBJ4IFIAAF?EII@C:EGD7AD:B3FDFFE6@B?C;A?F@BGD/B?DD8FDIHBEHDDGHE4=HG?B<:AC*IICGAIIHH2FHC?==>G>GE7IG>FBH;GCHCEI;HHDIFGGGACBCDJ8IJHGFF2J@>'7;A@FIDDDCE><<==>>BD8@DCA@AFC>FDEF5G?FEEFFJG8DGC7HAEIGG8B3>@EAE4JCIE?IAEBDHEEHEEGAB8.6E@=EECIEBAA(CGIC>IF>;.@BD3H>6B@BEIFEHIG:FHI>E<;FG>ECCF=>E?D@ICFGDACFADF:FIHJD@FFH?DE:?3>EAFE4;@+CIAD@8EJBGDGJIB,;EFFAG@?D=D>GID?;DGDCFH=GHHA2DB@DIDHJ9JHFHC@I@FGF:9:@&9CE:C8G.H7IF@FA@ECDEDGH@FIA@H>)CG=HEIIGIC:BGA9FGH@*822HE@3J?FBH@EGG5ID @rCer/1080/25_1788_CCS ATGGGGGAAGACTGTTACCATGCTGTGGTCACAGTGCCAGCTTATTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTTATCTTTGACCTGGGAGGTGGCACTTCGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTTAACCATTTTATTGCAGAGTTCAAGCGCAAGCATAAGAAGGACATCAGCGAGAACAAGAGAGCTGTAAGACGCCTTCGTACTGCTTGTGAACGTGCTAAGCGTACGCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCAAGATTCAGAAGCTTCTCCAAGATTTCTTCAACGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAAGTCTGAAAATGTTCAAGATTGTTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTAATGACCGTCCTTATTAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTCTATGAAGGAGAGCGTGCCATGACCAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACGGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAAGAGAATAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGATTCCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACTATTGAAGAGGTTGATTAAGCCAACCCAAGTATAGGTGTAGCATTGTTCCACACATTTAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATT + 9:2?C?B5>579):*?;.?%2;B2=:=:A8C:AA4A8$=9,0A@5:<92398>>?=AB;BB87:?,@>:6:A>6=C?9;>CAA>>2C(@94><29;.;(.;,1%-,;;;1C4:A?@?0:EB:EE3BD2C3@5E@:?6CD?+@BBD>5>9>?EF0E)EE2C2?9B5)<=7:7=DC69=@=AA>C=DB72@AD?AADA+BACCF;?6:ED9GFBFE&<(@CC=0D9=;7EE>>+?:?B72FGB1=8:.B;7?@?<DF>;DBEBBA.ACBAA?*ADDFEEC=7@>D:DDEAE7JEA?D>A?D8?EEAG>BFFD(BAC:JI0EFHCECCA1A$@AF?@C<0BB@CDHGI97G=CACC=A:F?C3B:EI?DCIBEJ>HD:GFCFF>?-$CG2@HG?FHIHBDCICBHB;J5CA>%EHIGJHBJFAD+?A?;1DE<>4FB@BEBGF-@D8E9DEFGA8G@HGF>HFHGD;GDBDJFCICDEG?FG?C>EIDIAGIFB=BFBGE9BHFHHADIHH1HE=GBD2DC&BE;2FEG1GA-GIG79=E=G;7G?BGED@1J=EBF9DG;:FEHADGH6A?C68DIDHHIEDG1C@CHE>AFA<8ACGHGIBFEG9CFHIFJBEEDC0?>7@DH=GE;A*FE?B5EA3HFEFIFAH:IB=JH@CGBDC?@HE=EB9CHIDBDI9I@F;B8G+;@GI?HDFDEIIFGGIII@FDH?GF=EFACGEG.HACFF?>I4.>FBIGFHEIGEE>/@CCE>F@IHJBIHFGIEJH>D=GC<=CFBBGFIF@H@DFHIEGGDFCB.>@C>@B3AD?@7@B=GBFFGE?HG<>@;DGG?6HHGDE1EE5D4B9ECAHEDAHEGEHAHI;@HEEIIGICED?AA2>6=?@)A?>@5GF>=?D>>D@GED=HHEHF;==D9EH.E?+BBHIE7GB6GF=G@EC9B9<=CGIBF9EDBH=BCIEDIGI=F==9?A==D?DCGBCJHEIEIHHJII:FBB;FEC;9=FKFK7FDH?>E9H@IKJDJEHDG=EGGJ0?AFJKF&GJJC@JEHFAGJKBJGAIDDJACJF9KIEFCHFGJGHFIGEJJ:KKIJIJEJKFIFFJK:IHH3C8JJFKCJGHK9FCFDF?AJGJFGHHFJKDCK;JEIIIE3F=*D3E<:CDEGJJKJIKG8II4HHKKDIKIF?CKIGHCKJBKKJI@DIH=8DEDJ8GHJF7GC%?6:;IEKGE2A?CEB;KKI=KEI?HDJIKIKIKH=GG=CJDJ5DDGIG=FHDDJHKE@9GK3HGK8K @rCer/1081/1642_55_CCS ATGGTTATAAGCAAAGAAATGTTTTTCCATTGTCTTCAGATGTTGAAAAGAAAGCAAAAATTACTTCTAACTTAAGACAGAATTTTTAACAAAATGAGCAGTAAAAGTCACGTGAACCACTCCAAAAATCAGTGCATTTGCATATATTTAACAAAGACAGCTTGATACTGGAAGAGAGTGCAAGGAGAAGTCTGTACTAACAAAGCCAATTCCTCAAGCTCTTACTGGATCATTCAGAGTGTGGCCATTAACCCAACATGGAATTTTTCCATATAATCTCAATGATTCACTTTCATTTGAATAGGCAAACCCAAATCCATGCAAGTGTTTTAAAGCACTCTCTGTTTAATCTTACACCTGAAGTCTTCATGGTGATATGCACTATATTCAGTATATATGTTTCCTATTTCTCTTGTAAAACTATTGCATGATCCAACTTCACAATGAATTGTGCTAGTGGAGAACTCTATAGATCTTAAAAATGAATTTTCTTTAGCAGTGTGTTACTCACATGGTGCATCTTTAGCCCAGGAGGTCAATATGTCTTTAAAGCCAGAAGTCACATTTTACCAATATGCATTTATCATAATGGTGCTTAGGCTGTATTTCAAGCTATTGTCTAACATTTTGTATAAAAAAGAACAACAGAATTATCTGTCGTTTGAGAAGTGGCTTGACAATCTTTGAGCTTTGAAAGCAGTCGTTGTGTGTATATGAATGCTGTCTAGTGGTCATTACAAGGCATGTGTCTCCCTTGGTTAACTGATTTCCTCTTTAGTCTCTACTGCTAAAGAAGTTATTTTGCATTTTGCAGAACGTTGATTGCTAATCTTTTGCTGCTGTTTTTGTGTTTTCATGTTTACTTGTTTATTGATCTGTTTTAAGTATGAAAGGCTATAGTGCCTCACTGTAAATTATAGTCATCTTTAAGCTTATTGTGTTTAAGAAAGTAGCTATTGATAAACAGAGGTAACGCAGTCCTTCCTGCGCACTGGTGGAAGAACCCCTAAGAACCTGACCCAGTGAATGAAGCTGAGCACAGGAGACAGGAGCACAGAGTACCCTCGTTAATATACTGCCCTGCCTTACCATGACATTACAAGGAAATATCCCATTCTAACTTAACAATGCGCTTCTCAAAGAATTAAATGTAGTTTGTACAGATAAGAGAATATACTGGCAGAATGAAGTATGTTTGTTATTTTCTTTAAATAAAAAGGTTTGGAACTCGGAGAGTAAGAATATAGTATAGATTTGCCTCAACACGTTGAGGCCAAATAACATGCAGCTAGGCAATATAACCTGTTACAGAAGAGAAAAAAGGCCGGCACAGTGCTTATTCCCGTAATCCCAACACTGCAGAGCCGAGCAGGAGTTCGCCTGAGCCAGGAGTGAGACCTACCTAGCAACATGAAACCTTGTCTCTACCAAAAATATAAAAATAGCTGGCATGGTGCACGTGCCTGTGTCCCAGCTACTGGGAAGCTGAGGTGGAGATCACTTGAGCATGGAGTCAAGGCTGCAGTGAGCCATGATCATCACTGCACTCCATCTTGGTGACAGCAAGATCTTGTCTCAAAAAAAAAC + @;8(+(,531'78?,@FB87)BCB;$=%>E49/1@'F3',5.E(;JJJ4FDH'A5?=BD%C1;(B6G;@5&@8J=-?H7AD2GHGI*F6@FG?4-;4+>H)?E@=,3=;>.?><;&4$-F,60DG0G7GK3K8CHKJ0E)KIKK&H+AGF:I'@I:C?(EG'FF@D@KKA(CJJ3JKEIHKAGJI)JJ(DE%JI&C?IGK176;+@BF%<=FF)8B??%:;JCIG?@1&?+>9@,A832=;<2,)AII1JDIKKKB:83I8GCDGF)*6=E1=>AIDI3E3K,%'=,AKF1E:4)8)D84BE(3CI9*@DAD>BDBG0FG(FA?D58BGH57@.:<-<<>/8$4F<'EC+1H*HJ;.;B8?A6?B@CGJ.;D/J577:28BEF6><7.6=%'8:D@;F9@G2GF8@AGA02D-<3ACG3?:--?488/8DAGID(EH@;;G:5:/GFDEA>@EJJB483B1%>A)$=*1987-1**C77;;:;?)>=?,.8/+8-<=4<9&.93$1;695/33;=BA*272;@48;<$1:73*1:'+==+=@0692&.=<1=;??=<*<2/1+#/:6.6<=)20@>>*6;BA:93&/>2%'9AACC6?8.;C@67/=54;1%&*%9<8:87?:;2>97:;94>>+855&684/1%+,9'15,3.75)($5)4*3317+99$,-444&(:*/1&06&6-/34(&1.&.).$',/3/1*.-*,/'13)*%1+(+/'&'4)$'*+045/5*43)30/(((,)#%+,)6/2).0/43*3+3430006-*1/0#,+)0/.%.,*53/%-.0*&(*01+00/*0011'4"&,+*%$&63,+$++',$*234*0$0.*+'2/4066--$*0-%2605/,//615//#-+%%12425-$''&,)#&%1/#*&+2+32(0.(.//0$.-*/.7(&*+-1/5/983;5.53.)2467965%3$$256&4:/025*26467%5)/-)5,205/$((2,5-680,2.2110175613((5$0/.4852510/&,&)8%//9:575-41+(*3&1564)-10+%%8%2'%70041*//--2344858&-+3)8'50/22,#68.)6'87(+5:+%;;56.7501.81.%$$&41(240&0&,)(26),37*53/,)'(&&//-;3088,64,32(-$&"$0'0-+$&$&)(,14+59::/,1*7954()3.657%485.%#%,.0+44:0.8-+,03(424)1-(895:1443176-/0%*$131649--'*./-2%((886(0%((2/3183-+7'793:8:3#$-1%3346.3-1)36)8-0344/9662+0333)+2654-1899998(& @rCer/1083/25_1829_CCS ATGGGGTCCCCTGAGCCCAGCCAGACCCCGCGCCGCCCGCGCCCCGCTCGACTCCGGAGGCTCCCGCAGCCCCGGCGTCCGCCCGCTGCCCCTCCCCCGGGGGCCATGGGGGCGCCCCCGGGCTACCGGCCCTCGGCTTGGGTGCATCTCCTCCACCAGCTGCCCGCGCCGACTTCCAGCTCCGCCGGTGCCAGCGGTTTCGCGCCCCAAGAGCAGGAATACCAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGGCCTGGGCTTGGGCCTGAGCCTCATTTTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCCGAGCCTCCCGGGTCCAAGACCCCCTCGCCCGGAGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCCGGCTGCATTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGAACCAGTGATGGGGATGTCCCAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCGCCATTGACCACCTGGTGTTGGAGACGGTGGAGAGGCTGGGTGAGGCAGTGAGGACAGAGCTGACCACCCTGGAGGAGGTGCTCGAGCCTCGCACAGAGCTGGTGGCTGCTGCCCGAGGGGCTCGGCGGCAGGCAGAGGCGGTGGCCCAGCAGCTACAGGGGCTGGCCTTCTGGCAGGGAGCGCCCCTGAGCCCCCTGCAGGTGGCTGAAGATGTGTCCTTCGTGGAGGAATACAGGTGGCTGGCCTATGTCCTCTTGCTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCCTCCTGGGCCTGGCGAAGCAGAGCAAGTGGCTGGTGATCGTGATGACGGTCATGAGTCTCCTGGTTCTTGTCCTGAGCTGGGGCTCCATGGGCCTGGAGGCAGCCACGGCTGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCTTATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTATTTCCTCTGCAACCAGGCCGTCTCCAACCCCTTCCAACAGAGGCTGACTCTGTCCCAGCGAGCTCTGGCCAACATCCACTCCCAGCTGCTGGGCCTGGAGAGAGAAGCTGTGCCTCAGTTCCCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAACTTTCACCAGTTGGTGGCACTGCTGCACTGCCGTGGCCTGCACAAGGACTACGGCGCAGCCCTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTGCTCTTCTCCCTGCTGTCCGCGGGAGCACTGGCCACCGCGCTCTGCAGCCTGCCCCGCGCCTGGGCCCTCTTCCCACCCAGCAGGAATCCAAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGAGCCCTCCTCCCTGCCGGACTGGACCCTGGCTCCCCTCTTCGTTCCTTCCCTGGCTGCCGGAGGAGACCCCACTAACCCAGCCTGCCTGGGCTCTGACCACTAACACTCTTGGCCACGGACAGCCCGCACAGGACCGCCTCCCTGTCCTTGGCCTTGGGAGTAGCTGAGGGGGCAGACTAGGGAGTAGGGCTGGCAGGGGAGGGGGCAGACAGCCTCACACCCTTCATCCTGGCTGCCGGTCCCATCCTTGGAGGGACTGAGCTGGGGGCGGGGGACATGAGTCCCCCTGCTGCCCCTGCCACATCCCAGTGGGCTCTGACCCCCTGATCTCAACTCGTGGCACTAACTTGGAAAAGGGTTGATTGAAAATAAAAGGGAAGACTATTTTAC + D=2@C?D1?DB:6)0.:256:A@?A(9?7671*;4-6877=*97==6>A>96>2<;5;>?:<1GCB&A>?3&3AD7+8:;>=;FC=@E=6=<9?::49:;4:<5:;<9A:-73;:4<'8<9)0*1376+>>6=:1:;;C>B;B==593596A941825?=@<@>@0@406;77>;9589C.844?6;=)8;6/7;7>=;C844:><<53;/5/(49+;&8:84B27580;B;57>=5:7>??>9645>;<<@?<=2=8>>79;*;17-;:95?7;)475>,79606:?86?>>>?::5=4717=@:?@.=9;@35:=<4C;=@;7,1>A8/=?7&/:-.-6?;67:;67@@E8EGE@E>E9D8=C=2<@>2;F8<56:EA9%:<8.BA4ACE@5@AA=?;DF9EGB?8=3>71/@754-<5;D0=88DF;53949<6D=AF>C1=F:E?;3;7=(>4CB58;==5C?=.4@BE8:=9D5=::EA75=8:?=4<@DBI:J@DHE0@CE9@<+>B=;B@DABGDA<4-B@B3;=D-G@EBE=A2A4;B?D?AHI?8BE>7IA@A8CAFEABA>7BDD?4DA3BC@EFHAE@E<84-=1:G?403.99:3>;H<0A>>C?999?3B2G7.--9F8;:@>D+FDEF@CCF?BH;AB73F?3;=AAHCDDD>F?;HFB>:E@B.4@B9DF@:C?ADDE;EGDCBCE9DD?8,@H=EE3BE=E;FJEGC?F8D>:4D:FCABHEIA1E8GF8<=A9E2D9;7/4=:86B;)4:<:9;FEH6BHD>@JH?C3D>D?=>>?:=<:D5E=H<?FE@<;6:3GC?DD-D;A@I@K<:2;>:?@>.:7????<@E1:;;>=->FFCA?G?8G?H7H<5C?-=3;DGKJBEA8H@BFB>=:9=8HG>@EJCCGADI7GA-=0<;,=5GBHCFCEJ7/6A9BCD9:5B=:B9BDB=C7??H===CFE:B7=F4508+;>>G;8B4E164@2J3IDB4C4HE@>:H@.07649+@AEB2E3G1<@=AFHJ=J?@9>E9CDC8ADC8A?5A5===8?76@?;F767?:.<=??AEH??5I>>6D@H>35F&CB@F2;EF>A?B?-DBG/GEC76A>AHAABF)EC60(:=@@GKAJ5FC?D.G=FIBH=JI8G8@?A?FCCDCBEJ76H;=?HD>8-8EJ5BF;DEDA7FIIIE6?EG3IGF:II9:@JAD=F(;EHF3AHKHKEFIAFAGJHGDD1HKIHK;GJC0D7@DG&I$FAG;FEF)?CJIH2@EA>FD>(IG>GJFF(GJK:J7IKJKG?JKB7GHKEHKG85BKKIGIKJD?A?IICIJKJJCDHH7J;KDGGJ?KFJB>EJC6>FI=I:>?H8FJI@FJ=@<0E>CCAH0IKFAJK'JK5IEKBGHCJGEC=GB$:6FHGECBIEEG+JGGE7CK=KK>J@GHI>CDGJDHFGB93DCA<6,C;8G&B5,G;HCG>G2GI/FJ@G4>ECKDKFI9CJ9IKI@JD=JAJIKHKF>JE9EJ8FIKCF=:EK?FJEJ.GIKIKGKAH4IIJJEEAE=BDDE?EICKJ.J;KH@>EJEKK@JKJKKIJK(KJK1JJAFJJKJEEI@GD*EK:E?K7I@<3J9BJ@EGHJBFKCIH@?HDHAHJKHKIJIJJ+FKH?KAK4GGIK=J?=<4EBFIJK?IEF=K3G,KKK6IKGJJGHCJIKBFJIHKFBG;A>?C+JHJBD5KKCGK*BK,K;JDKGJCJHEBFGFDJ=JJKJ1'GHKI32>IKKEKCJK?K:KDKKJJIJ/G9EBD)KI;H:EJ:HJKGIFE8KI%KIFAFC5FFAGKII;@KK?JCIJKKFDAKK/F7HGKDJJFEDK>IIJJF6GGKJIE37IKK>IF:>HGKCE3H?IA?H2DGC;IIK9DI>AIG#-,2<@@=4+G?(:@A3BBC8IJIKKJK9J2HII?IAB86F682F>A07B9>GGDFGKD@FAB<=<'@EC8G,<<77>DA>9B68;1DBE;JFADB;D/<1-B%2JJ+FGKGJJBFJJ4BGHJH5@EE3=HI@?DGFK1>?A?A9?>FF7@B1EDA>K;HED8.@AFJ?K,J9HGH;BBIGKKJ5G-8?9H<@@.EB$36;D@ADI>-CC:@F;IHGG7F?D<2=:G31@2@59=78BADABC+FEFI+DC=EG9I;IE?BBCB4FDF.BAC4E>E?;A;A?D?ABHAFBGBEECE3@-BEH=B>@;B?DG>?E>DF7IG8<@8=7@CBF7A=C>C6:=4D=G@D>?CA?; @rCer/1089/25_1789_CCS ATGGGGTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGCGGGGGTCCCGGAGCCAGAGGGCCAATTCCCGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCGCTGCCCGCCGGGGTCCCACCACTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAGGAGGATGACCTGAGTGAGCTGCCACCACTGGAGGACATGGGACAACCCCCCGTGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTCGCTGCCATGGAACCCGAGCCCGCCCCAGCCCGGCCCCGGAAGAGTGGCTGGACATTCTGGGGAACGGGCTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCACCAGGTTCGAGCCGCCCAGTCAAGGGCCAGGTGGTCACCGTACATCTACAGACGTCGCTGGAGAACGGCACACGGGTGCAGGAGGAGCCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCTTGGATCTCAGTGTCCCACTCATGGACGTTGGGGAGACGGCCATGGTCACTGCTGACTCCAAGTACTGCTACGGCCCCCAAGGCAGCAGGAGCCCATACATCCCCCCGCATGCGGCCCTGTGCCTGGAGGTGACCCTGAAGACAGCCGTGGACGGGCCTGACCTGGAGATGCTCACGGGGCAGGAGCGCGTGGCCCTGGCCAACCGAAAGCGGGAGTGCGGCAACGCCCACTACCAGCGGGCGGACTTCGTCCTGGCCGCCAACTCCTACGACCTCGCCATCAAGGCCATCACCTCCAGCGCCAAAGTGGACATGACGTTCGAGGAGGAGGCACAGCTCCTGCAGTTGAAGGTGAAGTGTCTGAACAACCTGGCGGCCTCGCAGCTGAAGCTCGACCACTACCGCGCGGCCCTGCGCTCCTGCAGCCTTGTGCTGGAGCACCAGCCAGATAACATCAAGGCTCTCTTCCGCAAGGGCAAGGTGCTGGCCCAGCAGGGGGAGTACAGTGAGGCCATCCCCATCCTGAGGGCGGCCCTGAAGCTGGAACCTTCCAACAAGACGATCCACGCAGAACTCTCGAAGCTGGTGAAGAAGCATGCAGCACAGCGGAGCACAGAGACCGCCTTGTACCGGAAAATGCTGGGCAACCCCAGCCGGCTGCCTGCCAAGTGCCCTGGCAAGGGTGCCTGGTCCATCCCATGGAAGTGGCTGTTTGGGGCAACTGCTGTTGCCTTGGGGGGTGTGGCACTCTCTGTGGTCATCGCTGCCAGGAACTGACCACCCAGGTGGCCGCCACTCCCTCTGCACACCATGGACCCTGCCCTGCGCTTCCCAACTCCCCCAGGCTCCCTGTCCACTGCCCTCCCTGGTCTAGCCCCCTCCTCCGGGTTAGGGGAGCAGGGATTGGGGGTCGTGCAGCCCAGCCAGCAGGAGGGACTAAGGCCCTCTAGGAGGAAAGCCCAGAGGGAGGGGGCCCTCATTCCTTCAGACCCAGTTTTCCCCCACCCTCCTTAGTCTGCTGGGCTAGGTCTCCGCCAGGGCCGGCCTCAGTTTCTCCTCAACAGGCCTGGGGGCAGCCCTTCCCCTGCCTAGTCCCCGCCTGAGTGCCAGCCCCCCTGCCCCGCCTGCCGCCCCCTGTCCAGGCTCCCTCCCCGCCACAGTGAAATAAAGCCTCCCATCCTGCAGTTTCC + HK=KJIHJJ:KFKHJKDKHKJHKJJK9KIKHKKH4KKKIKFKKKI?KKKKHGGGKKKK;IJEGKKK=KJJKH=JKHKGKBKIK>JKKHK?K;I;IKHF5KKKKKHJIBJJ?HCKK>GHFJKJKJKKKKJKKJGEKKIIKKI<@KJK7JKJKKAKKG@H4KKKK=KJKHIKKKKKI1FFJBKJKB?KI7JJ6KGIKKKKKJKKKKKKKKKKKKKIIKKCKKKKKKKKKKKKKKIKKKKKIKDKIKKKK8KKKJ?KKJKKKKJKJCKKA?KKKKK/JKKKKJKKJKKKKCKKKKHKKKKFKKKKJKIKKKKKKJKJKKKKJKIKKGKKKKKJKIKHKGKKKKKJDK9KKKJFKKKKJKKKKKKKKJKKKKKKKKKKKKKKJKKKKKJKKKKJKJKKKKKKKKKJKKKKKKKEKKKKKGKKKKKKKKKJIKJKKKIKGJCKKKKK0>IJJD?KKKKKKK?KKKKKKKEKJJKHKKHKKKKKKKKKKKJKKJKFIIHKEKFKIKKKKKKKHKKKGK=KKKKKGKJKKKKIKIKHKKKKIK@KKIKKJHKKKKKKIKIGKKKKJDGKKK>KKCKKKK?KKKKKKKK8KKKKKKKKKKKKKKKKKKKJKHKKKGKKKHKKKKKK8KKKKKKKKIKJKKFKKHKKKKKKKKKKKHK@KKKKKKKKJKKKKKKKKIKKKKKGKKFKKKKKGK>KHKKKKKKKKKKKKKKKJKKKKKKKKK?KKKKBKKKKKKKKKKKKK @rCer/1090/25_1529_CCS ATGGGGAACGCCCGCATGTGGTGGTACTTTGGCTGCTACTTCTGCCTGCCCATCCTCTTCACGGTCACCTGCCAGCTGGTGACGTGGCGGGTGCGAGGCCATCCGGGGAGGAAGTCGGAGTGCAGGGCCAGCAAGCACGAGCAGTGTGAGAGCCAGCTCAACAGCACCGTGGTGGGCCTGACCGTGGTCTACGCCTTCTGCACCCTCCCAGAGAACGTCTGCAACATTGTGGTGGCCTACCTTTCCACCGAGCTGACCCGCCAGACCCTGGACCTCCTGGGCCTCATCAACCAGTTCTCTGCCTTCTTCAAGGGCGCCATCACCCCGGTGCTGCTCCTATGCATCTGCAGGCCGCTGGGCCGGGCTTTCCTGGACTGCTGCTGCTGCTGCTGCTGTGAGGAGTGCGGCGGGGCTTCGGAGGCCTCGGCCGCCAGTGGCTCGGACAACAAGCTCAAGACCGAGGTGTCCTCTTCCATCTACTTCCACAAGCCCAGGGAGTCACCCCCGCTCCTGCCCCTGGGCACACCTTGCTGAGGCTCCAGTAGGGGTGGGGAGGGAGGGAGAGAGGGGCCGCCACCCCCGCCGGTGTCTGCTGTTCTTTCCCCATAGGTCTTGCTTTGCTGCCTGTCTTGCTGTCTAGAGATGGACTTGGTTCCTCTTGTCAAGGTTTGGGAATGTCAAAGCCCACTCCCCACGCAGGGCCTTTCCTGTCCCTTGTGGGGCCTTCCAACCCTGTCCTTTCCACTGGTGGGTGGTGATGCTTCTAGGTCCTTAGAACTGCCCAGAAACTCTGCATCCCAGCAGCTGGGAGCCAGAACTTTGCCTGCCCTCCCTTGGTTGCAGTCTCTCTTCTTGCTCTCTGCCTTGTAACCTGACCATACTTTAGTTGTGCCCTTCCCAGGCATCATCTTCCAACCCCCAACCTGGGGCTCCATCTTGGAATGGGGGCTCCTTGGGGGCTCCAGCTCAATGTGGCTCACCACACTCTTCTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTGAGACAGAATCTTGCTCTGTTGCCCAGGCTGGAGTACAGTGGCCTGATGTCAGCTCTCTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGCACCACCACACCCGGCTGATATTTGTATTTGTAGAAGAGATGGGGTTTCATCATGTTGGCCAGGCTGGCGTCGAACTCCTGACCTCAAATGATCTGCTTACCTTGGCCTCCCAAAGTGCTGGAATTATAGGTGTGAGCTGCCGCGCCCGGCCTCAATACACTCTTCTCTGGACCGGATCTGTCCCAGCCCTGGATGCCTCCTCCTACTGGTGCCTTCTTTTCTTCCAGAGGATTTCTCTCTCCTTCCTCCTCCTTTCTTTGGGATCCCCTGGTTACCCTATCCCACTCTCCCTGTTAGGTGCTTTCCCATAGGAGGCCCTTCCTGAGAAACAATAAACTAGGTAGAACTACC + FK2KGHCJHK:KKJKGGJIBKCIKKIKBKKKKKKKKKKKIKKKKIKKKFKKKKJKIFKKKKK8GJIFIG=JKGKKKKD=KKCJKJIKIKKKKKKIKKKK@KJKKDKKKKKHKEKKKFKKKKKKIKKJKJJJJKKKIKKKKKKKKKKKKJKKKKKIKKKKKKHKIKKJKJKKEKKKKKFKJIKDKKKKJKGKKJJKKDK@KKKKJKKKJKIKKKKHKKHKKKHKK?KKKKKKKKDKIDJGJDCFJBKKH%8CJKKKCKJJKJHJKKFKIKH>JIHIIJIJKIKJKKKBKJKKHKKKKKKKBKKKK:KKKKDKKGK4KKKKKKJKKJKKKKKKGK@KKKKJKGKK.KKKKK?KKJKEKKK>KD+GIJKKKKKHK*KKKKKKKKKKKKK8KGKKJKDKKKKKKKKKKKIKH9KKKKK=KKKF;KKKKFKKKK'KKKKKKKKKKKKKKKKJJKJKBKJKKKKKBKKDKJKIKKGKKIIJIKHKKGKDKJJJG@BKGKKDKKKJKKKKJKKK@JKKKKKKKKK@KKKKKKKKKKKKKKKK8KIKHKJKHKKIKKKKJ4<:JGIIKKKKIKKKIKKKH>KJKKJKIKKKIKKKKKKKKGHKJKKDKKKKKGKKKEKKCKIIKGIJ?JIGK>KHGKKK4KKKKKCKKJF?KKJ@KKEKKKIKKJKKKHKKHK>KEKJKJ3KJKIJKKKKKKKKK'KJGEGCKKKHIKJKHHKKKI7KKI@KKIKKKA?KKKHJK@KKFKJBIFGKKJIEAA3:?HIKKFKKFKJ;HK/HKKII?KHCKJKK9IHKKKGIDKKKIKK9KJKIGKKHJKKKKIA5K @rCer/1091/1722_53_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTCC + FCCC+;?A@<<+;5AG@CD<>9>A0DA;9:7DF>;@>;D?@BEDCDF?FB;E1BC;F7@?BAA@?>C@@5EBEEEDECBC9ACAB(>EEC@?(8;=1>B@@D@?FF8>@9CEFGAB<9C)BC:6;B67E>>DC>CC6B:<9>>E>=D==:4?9<$=@>AB=8A>BDD3D?CEA>?BECDC1?@CFC9A=:9D?C;@C@@FEE?==D8@>'EBEDA@B<0?89D?F@:@A3?BA=D@A=?@<4=7@?>6C?F@FB:;;FD??AADDC:)>>9<=>D<>?2;D?CF>A@@>B9?FE?DCFEB@@A4GCC?@BFE@=/?C7DB04;//A.8=ED9C5C;@?DBCD=8B>:?;(AEFE7>;5CDG@>BEDE>>@CD@7@<8&9DB;<AD?E;?8E7D=DE?BCAD88?=+C<5:B/FC?EB7D@=>@A=:@>>E4CA1/6EB@DEFD?@9;9@48>=EAB,CACA@>;;DD0?GD>CA9,E@>>DCF=9E?>B:>??B;:;>4CFGCCDA>BC5AEDB8?=DDBEEAE@@B?A<DD1C?>C?BBAE8@:ECD@?CAEF3>ADDA&>BC<=C>DEEGA7>)CEEBFEB?DEB4@CFEEDDDFA?ABD?8?EA@AEE@BF?BB@AE2A7,8.<@:>:@>;B>:C=BBE=ECA'BE?AEGGB8A>%BAGFGE?C:<1?F@FE@=F>2=@=9@@DDD>D@FC>CD:AED@B0=1CBF*G@E;FFD>9>65>>8<4>5;D?3EEE2CADC:?FBF>GAA@>?A;.B;FGEEAFCFCFD?:GCEF=EDB@F<DD;?=BEDFEACDE?7E7BAE2B@D>B@EBEA22=@ED?EGDDCE>AFC>D@EG=AB<=+=<@4B@DGF8CC>BFCAD;ADE@<+A@D?>@DBFC>@=>EB>CA;D;=<@GCA/@9E;D=G6CADG6EDB@@FDGEFGAFC@>?B=1B4DECCEGED5>4CAFADEE?ADEB9=9@?=?B&EDB=@8@,9529;>;>=CDD4C;@A;6C??+3BCEECG92DBC?AF>DCBE@??-=ED:CDD@CE:@@?AAB:?;CD8<<+G>FA>6A=D@CAA=AD?AC56BE9B;9=B;EF?ED=C4@CE5>F>E@DCEGCD;4C?9FCDE@AA6ECE7E?F?C@3@B:DDD(CBC:@FDBB? @rCer/1093/25_1839_CCS ATGGGGGGCTCCGCCCTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAGTCGCTGTGAACGTTCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCCCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTACAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCTTGGATAAACTGAAAGCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTATTATGTGACTATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTGTTGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTCAAGGAAGTCAGCACTTACATTAAGAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGTGCTGGCTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTTAATG + GF8IJA=FCFJKK;JJ5KKG.IKHI?GKF5KJIICE>DHEJCEFEEGJHDCHHCFEKID7EHIHH@C@DJ6IH@=BFJEDBEKF7GE@DIGEDIA8F8IGH@CEIDI-DBEDJEII@GIKKJ?F+K;BKHGIKFDD3?FGG9GCB6.EF,BIFD4BGJEJ?E6EBHJHDDIC28C;>CGICFE=EG?H?B8GC:?GF<8CGFAAGDGH=KGJFE:DF:IJ?FHE:JG;AE.C=7IJE93FBFFJ@G5AEIJF.EEH@KHJ?KFJJEDJ@KJK:E;KEGCEJDCJGKAK@HGACKKJJK>2DF@HBGIGK4EGJE@EGHAJJKKF1A?GII>GHEDFG8JJHIKKJCHEKICKFJKJ@HIKC>JJB:IKA6KGKGIID?G?KJHKIIIJJD>GGE:HI=EBGJGJJ=K:BJ=FIIDIJJK7DIDAGI@AHJKJKKDK@JJDJIJ95CKE?FGJKJJKGGEFD=@HICGEJ(K:BEB?K3FEKIHFJK;K3IDHF@HDIIGGKJKIJKGIIJF;IFKJKJJIJJJDH=HJKKIIEKH@J@HF>EGKFIIKHGKCKKCC>KFKFAEJA:KAHDIFGDEKHKAK@7IDIJJBJKAEKKIKKKKKHJJ7KHBJKJKKCFI:BHJJJE6CHHEFK9:K?0IIIHKKI@CJIB?6@BH5EHEIKKIJAKKDKIGHJKIIJKBKKIKKF?IKIKKKKFKJIFFKKHKFFGJKKGKKKKCGKK9KHD9JFF6KK=*BFJKFDIBFGK)JHJKD;CGKGFKIIG>CIIJDJ9KHJKJGKJKGKJ;KGKIKK5HCKIJJ=GEIKKFJIGKJKDDECH>;JIHKFHDHIJHH?KDGDKJIKK:KHHIKHIGIJ:=6HBKIJICCKKCJJBIK;B8?HKKGAKK,FHFBKKEKKJ@JHAIJF9FJIIFKDKKFCJA@HJJJ;E=CH9A@EAHJJFJEKIIJKKHDKJAEJHAKDKHEKKJEKJJJ@2DCIBDFJGI>JBKH;3/2DKKGH9KJJI8;DC@:BH@E;H3GC)@9G9@H>GKKFHHDEHGC@=JI9KEHCIJKGKJKKJGG2BFCDD>>HD>AGJI@FEJJKDG@;1ABE@GJJFK=KIKCKKDKJHKKCKKJK+FKJ6FIEGJJK-H?EEJJI>?7DIEJD>CF(@@F(DFCIJIKB?*>IG82JKIJIDI?KCEK3BHF9?HBEJCIK2KKHJ;GEKKJIIKKCJ:=887,65.4?,;=38<*<;1?9@4>:0@3B5@@.?EEEFAC>>BA?ACAFGFC@?%C?=FBC=B%4;<<4A:C?7238:>?7--=:;4@A:EB>BFEB=D=GF;C:BC<9-2AC<6A=9@B;;=85==;:CB892A.2@98@A';8:>9B9>@B@@>@AFC@A1;>'AA@=7@A@;;;A>:;@?;79?54;BEAB>E@?A@C@;=?CAFD>,@<6<<=AFE@A==B3AB<<=7>C>;A=CC9?C9FD:@=5A6>/<65=;>8;7CD/B=B+8@EA9CBB@F6<;8AA6CE4@CEAE5=C@?6ACA@6>B>@B:C@?CBEA697>BB:@;FEB:?>4<@8/;:697<9;<<184;>>??E8;46;9.0FFEC>EF;E1ABBC:;>;>@>@4;<:467?2<>@CBF<6C<:C7>:5>=D:CC@5:5=;2:AAB4;E9A2;ED>:=5>95;<;<=?@29=5<.6>@ADFA<46$<>@5>EE::F:A=>:EB@DFB@DA@9A?=EBE8>>=AECCCABE2FA6?9=EB@BB>FE1>8AE*A?C79==(A8?8=@;>;%;9;>;F7CBB?BB;>?B@>AA>3BG@CBE:@?F5BDAB>>AB=@DBEDF?B@?4DFBB@G@BEC*871ADAG;B=G?@=ECBE;EBC;BBF;A@ECDFFE?E;CC;;9CEB6-:2+%8:@@;7<=AC%9<<=75=?@CC9@?A>AD;E>AC)=:/=;CA1C5D@@:@F@EACBECEA=AB@EF>GE>FC;E1?@B::E;G?B@:EE+9>@GCA3=1?5>5>@DA@F@A=>?B@DB77?GAD@E5>CB<1473*A@;7=?CB;82<3@08,721::-@;<@CA8BB@B:?(9;@C?=0=A<>0:72?:=>B=7=>=>968)<<:;:?539;:;>3:?>139$38:.((64<839<3*<68'<8320598;>6<.;4:458=98=9>>;5078.:995?>979229==617?>7==>>::><92<>6?>:;=>??===?+9:6/576?97:>>;=1;92:<;>8=+:>;90;>=86877;;=:8<9<3:(;<9>==>:91*85'56>>?@6+6&7:84<:9@AA?B>7>>B@BAA=::C>59873<16,3086<=;553*88:387=5>9>>9683:';3<<,=;?6<>?<4;89<6>>;=<6<79563>827999=<8-9:?;8/5&8569<891=><<9=8)3879(;854:6:39;8==;6;7<:':6;3>?=81940<:=;<?<<682197348>6>348:2:4=89:=?;>9:6=67>=;2>:218116==95+1$06647:=>>782<>12230654(5:>94>787875:;77>>>59;68=>?>;:::??>=/8735)249332674;1;5><=7>=<>>297:?<<7&-/-549==+3;9:);6:7:=3/<==7=77;+7,8:;55.75677+74,%69>8>94<8<,62:2>4/9<97:09:>98055=21:$0361====>9<7786;7:6/=9;<=:7):75617>='8/...37585?9<>8(5:477<-%,996>;?4=.4:6<(88<0912305>;<3371936/2,736).40265415/5:468,5367')--.*440506164543/4034648.(/*-*3--+25687735-1*073/3459758005/772$476443:1306;581933104--*66.514410,0/4231'.0221+0875:7;24764.7:739:74+737:44.60:=;&/)004*37;22644511868?<.632514<:3943/60709383:8/642><98%<532:,6<<2454753:99/1)16&+47-7&+.)'$)22/11.-9(1--6+2/*47519352697159645.1046%/2653170544+567/372441849:4.47253131.,+.22550'***+.4-576.982:6808338&10.039.879:6:985852:./2121).%..-27398516,83.*2-./222.427738276-54,776:86/444*+2352,-0725.342+2/36407-5,:9.500/+278)4/-/1.45/8847559:376:8.8::0-/)892,.599.5:39;8:58466.60940.39:1+05..7/05/0842/30-34+12/201,1682)53/2+/.1513-,2))2(1*./9927/99978:160-493:8:+78:*66%35::3/41*,99636,/223)62369836:<85315:8978925<65<<<*798<39>;26$491=51<9<<56<-68=7<6=:;?:>=;7=<-90.04*277)14/45+8797<=46<2-0/39>9834>6=7==:62'4/77;71?.5)92.*2%.65.33>73444&;>7)9<53&73127?;?24856757968493<853576;4*7$*+:426:+,:-:2:603292177;2686=69*?42'83534-5=5;21(*45:@AA=23B18<'72,//141;1-/3+063220)./70)'*--1/.1123/577/7399?307;86084.=,183A91495<89<7@8<79=<>=0562:3;4(620//133/3=2--02:07034,5)4<96.;3;::6:;6.43*<835;@F?=<+DCD=<<>BA<0:/.9?,=<9D7?F5*57-045264./;5B=2616/ @rCer/1097/2052_60_CCS ATGGGGATGATTGATGGGGACAGGAATAATTCATTTGAGAGACTAGAGTTGAGCCAGTATTCTAGATAGTGAAGTAAAATAGTAATGTAGTGATTTAGCATGGGTTATCCTTAAATCCCAGTGTCTTAACATAAGTGTATTTTTTATTCATACTGCATGTCTATGGAGGGTTCGCAAGGAATGCTCATAGACATACAAGGAATCCAGGCTGAGCGTGGCACCATCAACCCATATTTCATGAACATAGTGTTGCTGGGGAATTGCAACATGGTATATTACACATAGGAACAACAACAAAAAAAACAACCAAGGTTAAATTTTTTTTTGACTGCGCCACAAAATGTATGAATTGAACTTGCCATGCATCACTAATAATTTTCAAATTGACCTTTAGGTTTATATTAGCAGCTAATTTTTTGTGGTACACTTAAATGTAATTTATGATTGGCTTCTGTATATAATTAAATGAAAAGCATTACAAATATTTTTATTTTGGTATTTCTCATGATCCTCAAGTTTTTTTTTTTAGGTGAATCTATTAGCTTTTCTAAAGATAACTATTGCTATTATTTATTTATTTATTTTTTACAAAATATTGGCATTTTAATCTCTCTATAACTGGAGGGTGAATTCTTTTTCAAAGAGTAAAACAGATCCACAATCCCTTATCTAAATTCCTAGTTTCAAAAATTTCTGAAAACAAAGTTTTTTCATAACTCAATTTGGCAACAAACTCCACCTGAATTATATGAGGCTATTTGTGGTATTTATCCGACTTTAATGTGAATATGAATATATTTTGCCATAGATATATCAATATATTGATTATAAACTGCTTCCTCAGACCCTCTGAATGTTTTACATAATGTAAGTATATGCCCATATTTCCTTTCAAAAATCGGAGAAATTCTGAAGTATCAAACACATCTGTCCCAAAAGGTTTCAGAAAAGGGACTATGGACCTGTATTTCCATTCTCTTAAGTTCAGAAAGTGATATTATGATCCAAATTTAATATACATAATTTCCAAAACAAAAATTTTCAGGTCCTTAGTTTTCTAAATTATTTTAATATTTTAAAAATATTCATTATTCATTTTAACCTTGAGTAACAACGGGAAATACTTTGAAATGCTTGATTTTATCATACCACTAGGTGGCATCTTTGTAAAATAAACACATCAAAAGAAATGTTTATCACATAAATAAATGCTGAGATGAATAAAGGTAGATGTGACATGAGAAATACAAAGTCATTTGGTGGAATAAATCCTGAGAACATGCATAGATTTATCATGAAAAGGAAAATGGAAAATGGTATTGTAAAATTACTGTTTCACTTTGGGAATTGAGAAGCTTTTTTCTATTGGTTGTTTTCATTCAGTTTGAATATACATTTATTATGTAACCAAACTACATTTGTGTGTATGTGTGTGTTTGTGTGCGTAGACAGGATTTTGACATGCTAATAACCTTTCCGTGCTCCACAGACTACCAAGGAAGCCTAACTATTAAGTTAGGTTCCTATTTAAGATTAATTGTATAAAGTCATCCTCACAGCAAATTACAAAAAAATATGAATAGTGGATATCAAGTCACATTTAACACTGCGAGACCCTTAAGTTCTCTCCTACCAGCTTTTCTTCCCCCATCTCCTGACTCTATTCCTAAACCTACTGTTTGCATACTGTCTCTAACATTGAGAACAGTGAATGATAAATTTTAAAGAGGAGACCAGAAAAAGTGAATGTTTAAAGCCAGTGGAATTTTTATTAGTAGCAGAATGTAAGATGTATTATGATTTTGGAGATGGGAGTGTATGAGTGTTTGTAAAATCTTATCTGCGCACCTCCACACCTGGTCTACCCATCCAAGAAAGCCTAATTCTAGTGGTTACCTCTATGCCCATTTTTCCCCTTTACTTTTCGTGAATGTGTGGAAATGATTAAAATGCATTTCCTTTTACTGATCATTATTAAAGCCAATTTTATCT + 26)461004464644156,453/*5/1./6/2214.3-2554036554610202.1253343624-154640)000-1&41522156223456663354266215,3/4+62.2%56611552016064326640534234401*06164.53*34023613365552003.530/&52044,43662'0.400-36264424614611151020.4-151*,1/-*.-*00/-(&'*0/.,00-,11100/10+).$1,1*0.011101,/,/*/-/',.+,/2./,-1,,0*..0/./.0*12/200*0,.).1',+,.//.+#+-11.0/.%,,+-0&,-0-111*2-.0-..-12.'0,,-11--.21.0)/21,01.*0*.)..11)020021,'*-*/1111112.///00(0.21.110-1*220110/,01*-10120201/11-0*),11-,202,1111//-11121.011-./,00*%+010'*,1022.,)/'011.21.-.&0./0...---.$',+/11,-0000*1..120,10/0+,/,0*1112-.10,/,,.,-00,,,+0$+22222*,*01/)0+0,1,0+10/'().0/11.1/0/,/1,0/2'0010-*.,010/*/0-'0/---/,'1110.*'0./&//-&1'+-.*.0$'(0/,+012-0/0/0&/0(0/,011((/1*101.10**-12-0100,/1)1,12.1.1,,-210/1.020/+,-.0101+*1/11,,-1/,*0./*+,(+-102/201-1.-,*'),201111201-12.'/10011..10+)/11*/$/.1*-+,2,0.112.20*111.22.11110,++.0/$,011-&'*'/'0,0//,,,)',,,/.'20//%12222-./-&0,02,/*0,/*&/100.0,(01...1011-.*-00$1*10.110/..'1.*(/,11-/01+//-)0/$10/0-101212.01)1-*2201/1.11.*&)0112102/22--,*0-110.(&0.+*&.11)/222.,111+1,0*0,.++++,1.(1.10)/),.12,/*.-110)--&($0+.+,12/*--+,./))/,210+*0-,211..102,/1'0,*/-'/+0-11,*$/,(.1-10/)(+0/011,/,+1)1110-/*-&022-,.2,/1.-0)1+/%)0.%-../-.+/)/0.11-/1.*010,.01.0-01-,0-2-11111,0*/1,..0&02-,+-11%-10.0210.10+-&*/0).)(-)(#/#++-10110-,,-**++,+,/./&.,111*.1)),*%-0+%$-+,&-,/,,00.1.*1,00100*,1,2+1,*),0-+/.0/./$()(/(1/001-10(,-0/-++-0',0-0/01102.-12.-100/)0(00(0..0/10)11.1001110*+/-/000/-)+101/.11101.-)+/$'0.-*,1/0'/1-/-2.12+-/0111,.*,)+),)(&&,.&/.-2*/0'0/10../-/,/0-0*211/..*1/,*')/$.(),/12200++/,-)*-+),./0/*0,-)+/00/0&,/0,/,.+++..+*/,/0+.0101000..+10//0.)0*//,+1-1.00-/0-)--1020-.1100,02..---&++%-,-00-0,.+,.*-)//0$,*..,00/.&0-/+//)10/1000+012,,-'--/(**,0/-11/10)002010)11,+.*#+%,/.**+&0-(.&--+-&-.).1,0'/210-0/1+)-0)0.,./,,00-00&0,,./-**0*&(--/00#/110/120/*10*/-++100.,,'1122010./&/1,-01011..)+,00120'1/,0/*,.,-/.)1)0220)/*,/-/,.-/11200-/-%)*$,0/22-.0/2/0*'-#0./.,01-*,(.0---+,/-%#,+%01/-*022./10011+1,111,/00.,+102/-.&12,0-/0-10/*(*,/ @rCer/1099/2226_57_CCS ATGGCGGCCGCGCTGCTCATCCCCAAGGAGGACGGCGTGATCACGGCCAGCGAGGACAGAACCATCCGGGTATGGCTGAAAAGAGACAGTGGTCAATACTGGCCCAACATTTACCACACAATGGCTCTCCTTGCTCTGCTATGGCTTACCATCATGACAGCAGACGGATATTTGTGGCCAGGATAATGGAGCCGTAATGCTCATCAGAACCGGTGTCTGCGATCATCTTCAGCTTGGCCACAGAGTGGGTCATCAGTACTGGCTACGACAAGTGTGTGAGCTGGATGTGCACGCGAAGCGGGGAACATGCTCGGGAGGCACTTCTTCACGTCCTGGGCTTCGTGTCTGCAATATGACTTTGACACTCAGTATGCTTTCGTTGGTGATTGTTCTGGGCAGATCACCCTGCTGAAGCTTGAACAGAACACGTGTTCAGTCATCACAACCCTCAAAGGACATGAAGGTAGTGTCACCTGCCTCTGGTGGGACCTATTCAGCGTTACTCTTCTCAGGAGCATCTGACAACAGCATCATCATGTGGACATCGGAGGAAGAAAAGGCCGGACGCTCTTACTTCAGGGCCATCATGACAAGGTGCAGTCGCTGTGCTACCTTCAGCTCACCAGCAGCTCGTCTCCTGTTCTCGGACGGCGGAATTGCAGTGTGGAACATGGATGTTAGCAGAGAAGAGGCTCCTCAGTGGTTGGAAGTGATTCTTGTCAGAAATGTGAGCAGCCCTTTTTCTGGAACATAAAGCAGATGTGGGACTGATGGTGACCTGTGGACCGACCGCATTGTAAAGATCTGGGACATGACGCCTGTGGTGGCTGCAGTCTGGCAACTGGGTTTTCTCCACACTGATTGAGAGCTGGGCGACATCCACAGCTAAGAACAGCAGCTCCACCAAATGAAGTCCTTCCGCGCAGCTCCACAGTGCTGTCTCATGAATGGACAGTAGCCACTTACAAACAAATCAACATTTTTAGAAGCAAATGTAAAGGTGTGTTTTGAGGCATTTGTGGAACTTACCTATGGGACTAATATGTGAAAGGTCTATCCGTAGTGGTTCCCTGAAGACTGGAATTACTTCAGTGAAACTTCCCATGAACAGCGAGCTAATATGTAGTGAAAAAATGAGTTTTTAGCGGGAGACAAAAAGTCAAAAAAGTGAACGCTTAGAACTTTCTCAAAGCAAGTCACAAGTACAGACACTTCACTTAGCGTAGGGGGCTTCCAGGGCTCTTATGGCTGTTGTCAAACAGGAGCTGGGGGAAGGAAGACTTGTTCTCTCTTTCTTGAGGGGTGCATTAGGAACTTACGAACCAGAGACTTTCCTATGAACTAGCAGTATGTGAATATCCTCTACACTTAGTTACTGATAAACTTCTTAAAGAGATCTGTTATTTTCAGGTAGTGCCGTAATCTGCGCTTCGCATTGGCTTTTTTCAATAGTTTCTCTTCCCAGCCAGTGTGCCACAGGTGAACTTTTGAGGTTGTCATTAAGTAAGTTGTGAAATTCTCTAATTACCAAGGCAGTCACATTCTTCCCTTTCCCCAAATTCCGAGGACAAAACTTTTTTATGGTGCTGTTAACGTGGAGTCACACAAGCCGCCTGACTTTTCCTCGTCGCCGTTAGTAATAAGTGATGGGAAACCCAGCCACATTGTGATGCGAAATGATCCGTCTGATGCCTGGAACAGCCCAGTCCTCTTCACTGAAACAGCATTCTACTTGTTGTTCCAAGATGAGCCTCTGCAATATTCTGGCAATTTAATATACCCCACAAAAGCACTCTACAGCTTTTACACTATTTGACTTTGAGTTATAACTAGTATTATTCATGTTTTCATTAAAGAAGTTAGTGACCCAGAGCTGGCACAATAATTCCAACTCATAAATTGCTTTCCTAAGAACTAGCAAAAGCTGTTGTTCATAAAGGCATTTCTAAAGCTTCTGGGCACTGTGTACCAGCATGAGGAAGAGAAGAAATGAAGAGCCTGTCTTTTAATATTCCAGTATGTGTGTGTGTGATTTTTTCTGACAACAGTACATCATATATCTGTTTCTCTAGGATATGGAAATAAGTGGAGAGGGCCTACCTTTTTAAGGACAAATATAAAAATAGATAGCAACAGTATCTTTGCTAATCTTACTAATGGATATTGATT 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@rCer/1100/24_2043_CCS ATGGGGAGACGAAACCTCGGGGAGGTCAGGCGCTGTCTTTCCTTCCCTCCCTGCTCGGCGGCTCCTCCACACTTGCAACCTGCAGAGGCCCGGAGAACACAACCCTCCCGAGAAGCCCAGGTCCAGAGCCAAACCCATCACTGACCCCCCAGCCCAGGCGCCCAGCCACTCCCACCGCTACCATGGCGAAGACGCAGACATGCGCAATGAGCTGGAGGAGATGCAGCGAAGGGCTGACCAGTTGGCTGATGAGTCGCTGGAAAGCACCCGTCGTATGCTGCAACTGGTTGAAGAGAGTAAAGATGCTGGTATCAGGACTTTGGTTATGTTGGATGAACAAGGAGAACAACTGGAACGCATTGAGGAAGGGATGGACCAAATCAATAAGGACATGAAAGAAGCAGAAAAGAATTTGACGGACCTAGGAAAATTCTGCGGGCTTTGTGTGTGTCCCTGTAACAAGCTTAAATCAAGTGATGCTTACAAAAAAGCCTGGGGCAATAATCAGGATGGAGTGGTGGCCAGCCAGCCTGCTCGTGTAGTGGACGAACGGGAGCAGATGGCCATCAGTGGCGGCTTCATCCGCAGGGTAACAAATGATGCCCGAGAAAATGAAATGGATGAAAACCTGGAGCAGGTGAGCGGCATCATCGGGAACCTCCGTCACATGGCCCTGGATATGGGCAATGAGATCGATACACAGAATCGCCAGATCGACAGGATCATGGAGAAGGCTGATTCCAACAAAACCAGAATTGATGAGGCCAACCAACGTGCAACAAAGATGCTGGGAAGTGGTTAAATGTGCCCACCCGTGTTCTCCTCTGAATGCTATCGGCAAGATAGCTCCTTCATGCTTTTCTCATGGTATTATCTAGTAGGTCTGCACACATAACACACATCAGTCCACCCCCATTGTGAATGTTGTCCTGTGTCATCTGTCAGCTTCCCAACAATACTTTGTGTCTTTTGTTCTCTCTGGGTCTCTTTCTTTCCAAAGGTTGTATATAGTGGTCATTTGGTGGCTCTAACTCCTTGATGTCTTGAGTTTCATTTTTCCTTTTCTCTCCTCGGTGGCATTTGCTGAATAACAACAATTTAGGAATGCTCAATGTGCTGTTGATTCTTTCAATCCACAGTATTGTTCTTGTAAAACTGTGACATTCCACAGAGCTACTGCCACAGTCCTTTGAGTGTCAGGCTCTGAATCTCTCAAAATGTGCCGTCTTCGGTTCCTCATGGCTGTTATCTGTCTTTATGATTTCATGATTAGACAATGTGGAATTACATAACAGGCATTGCACTAAAAGTGATGTGATTTATGCATTTATGCATGAGAACTAAATAGATTTTTAGATTCCTACTTAAACAAAAACTTTCCATGACAGTAGCATACTGATGAAACAACACACACACACATAAAACAACAGCAACAACAACAGAACAACAACAAAGCATGCTCAGTATTGAGACACTGTCAAGATTAAGTTATACCAGCAAAAGTGCAGTAGTGTCACTTTTTTCCTGTCAATATATAGAGACTTCTAAATCATAATCATCCTTTTTTTAAAAAAAGAATTTTAAAAAAGATGGATTTGACACACTCACCATTTAATCATTTCCAGCAAAATATATGTTTGGCTGAAATTATGTTAAATGGATGTAATATAGGGTTTGTTTGCTGCTTTTGATGGCTACGTTTTGGAGAAAGCAATCTTGCTGTGAAACAGTGTGGATGTAAATTTTATAAGGCTGACTCTTACTAACCACCATTTCCCCTGTGGTTTGTTATCAGTACAATTCTTTGTTGCTTAATCTAGAGCTATGCACACCAAATTGCTGAGATGTTTAGTAGCTGATAAAGAAACCTTTTAAAAAATAATATAAATGAATGAAATATAAACTGTGAGATAAATATCATTATAGCATGTAATATTAAATTCCTCCTGTCTCATCTGTCAGTTTGTGAAGTGATTGACATTTTGTAGCTAGTTTAAAATTATTAAAAATTATAGACTC + 31%/1234465-132625/6655.356646625013-0335304&41216650-35154)1..25302425DBJ==5I;;=;HCGFFG5DDHJHA9H@;FBHHJGI4JJHGDHID:?8@HAII9DI?BGGGH?F*?DEGIGGFC9CCDDH>GEFG>B?IIA;5E>:7EIIJD>>H>;?FIHE;D?EIHIIHJDEGC>E9HIFHGGIAEIC8E==A@GFJ>GGBEB:GGAB:FHHHDIIB7E>BDDDADGDFFIGFCJ-@?DHBDHEHHJHIF@GGHI?IDBJ@FBFCFE8=BFBFG@FI;GG@BDCAED>AGB@FCGC:6D1@ABBCEICE*AIICJE9D:DDAE?6DIIFEDF?FJA<7C:AFBF?HE>HB?EFDHFBCJG@DJFIBGB?CCCH@FAD9HD?CC/CGEIFEE.?@JAGBIEDDC>DD>A@EH>H==AE?D>2HHEIHEIF>H?HE;FDHFF5H@FBG3=EH>IHIH=EI@EJIAICCIIE@EDGFG>9<;GACHGJGF>FBEIGHGIHG?EDD4I@IDFCGEJ?3CADDEFH=AEIIH=BC?GIFD;DEHF@GDDHIDGBGHDF:E=GA>I<5FB?G4HA>EF=<;G=IG9DBB@CEE=AEDIGEAHII6HDJAFBED?IB@HGEHBEID@)CBBCCI6FIEDFFIFJF:DGGEIED?IIH@&E.CHDFJ@HGHFFII>FD??H?G>IGHCJI?JJD@H47DAF@:ADG4HF@C?@6A2;=ABC@DEEHGJCHEE?CDIGHEIF5IFD8EF;6JH?GIEH:E&CGHC=BCEIHHEBHFEBGIECB+A7A>FEHBGFIIEI?IJEF>8@FF@GFDGHD?EGG;HDCDAF5B@C:GFDCB@EEDICGGDD6BIIIFCJFBEJIHHDIFDHFFIB:1CHI@:DCGEBADE@C@7AFCH>EE=G?5GFCIFFEDBEFIE?B3BEFB??AFFE>F?E@C@3>I:CA29>C?6@C>B?JJJFDDBHH>CAIF:?FB/?>DFG@DFE@<;I8E@?DFEIHIGFIIIFGGIIG<9A56B<3B2BEDDFA&B@?:ECDB<.DFB2;DCFJFGE@II@II@EEGCIHGIEIII:EF9B?DICAA7GFFH7GGD7=;BEE4DGHI?HE=DFA@FC@DH1GCFEGE=EFFHCGBF=EI>IGI=IJH?HAA4GEFBGFGIH:FAC0GC?B>DD7FH<=7GDE7ICDHB7F:GIHF:GCACIDD@D:G>&CBB==;F@HEEIIIEC@IIEEBH3@<9CD&C=0DI@BFA:C0?>7ADFF7??>BD>C,<>>495AG(CD11DDEE?ACGCBC:BEE?>@GEBF>FBCB9FIH?IDBCGFE=EA8BEA>AHH@H=DEG@FHHJ=IDGIHG@DGEHDFGD;HC@GIE&23><*ADHBBFEGDCIIJ9 @rCer/1101/1900_65_CCS AGGGCACCGCTGTCGGCCCTGCATCCACCTGTGGCATCCTGCGCCCGGCCATGAGGCGCACTCATTCGCCCTTCCCGGTTCATTCATCGTTCACCAGTCTGGGGCCTCATCGGCATCGGCCGCGGCCCTGGTTCGTGCCGAAGGGACCCAACCGCGAGTGAATCATCACTCATGCTGGTTCGGCCACGCCGTTCTTGTGTTACCTATTCTGGGCTCATCGCCATCCTGGGCACAGCTATAACCCCCTGTTCGGGCCCCAGTGTAAGATGAGACATTCTGTAGTGCCGCTCTGTGGGAGTGACTGTGCCTGACCCAGGTTGCCAGCTCTCAGAATGCTGTGGTCCACTGTCCCTGAAACCCCTTCGTCCGGACTCCCCCACACAGCTGTGTCTTGGTCTCCAGGTCCCTCCCGCTGGACCCAAGAGATCCGGACCTGCAGGGCTCTGCTGTCCTGGTAAGTCTCCCAGTTTCCTCCCAGCCACGCCTGGGCCTGGGAGCCCGGGGCACAGCAGTGGCCGAGGGGATGCCTGCATCCAGTACCCCGCACTGCTCTTGGAGTTCGCCGTCTTTCCAGGAGATGCTGCTGGGGAGCTGGTATGGGCGGGGTCCTTCACGCTTACGGAGGGGGCAGGATGCCAGGACTCATGCCTCATCCTGAGGAGGACTCCGTGTCGCGTGAGAGGAGTTGCTCGGCCCAGGCCTGGGATCCATGCCCCGTCAGCCAGCTTCTGCCACCATCCTGCTTTGGGCTGGTGGGCCGTCTATTCGGATTATAGGCCAAGGCCTTTTCTCTGGCATGGAATTATTACTTTTCTGACACATCTTAGATGTGAAATTATCTGAAAATGTTAAAGTTATGAGACATACACACAAAAGAACATAGGATTCCTGTGGGTCCAGATGCCTCAGTCCTTATGATATTTTGGCACCCTTTGCTGATGTCTCTCAAATATCCTGTTCCCCCTCCTCCACCCAGACCTCCCCTCAAGTCAATGATCTTCCCTCCCCCTCGACCCAGCCTGTCAGTGCAGGTTTGAACACGCCGCACTGCGCTGAGCACAGGGCAGGTTATGGGCCTGACTTGGGCCTCAGGCTGCATGGGGTGGATTTCAGTAGCCTCTCAGGCAGCATCTAATGTGACCAGAGCTGGGTATGAGAGAGGGGAAGGTGGCGTGGGGTGGCGCTATGGGGGCGGGCCCAGCCCTGCTCCTGGCACCAGCTCCCTGCCTCTGCCCCGGGCCCTGGCTCTGTGCTGAGCTGGAGGTGAATGACATGGGGGCGTGCGGCCTGGCGATAGGAGTGGGAACGCAACACGCAGGGGTTCCCTGGCCTCTCCAAGACTTGCCTCATGCTTACCCAAGCTTCGCAGGTGTTGGTTAGTGGTTTAGCACAGAGCTCACCCGCCTATGCTGTGCTCCCGCTGAGAGGTCTGTCCCCACCGGTGCTCCGCTGGTGGGCAAGCAAACGTCCAAGCGCTGTGCTTTCTGTATGGACTGCTTGATCTGGCCTCTCCGCCATGTCGCTGTTCAGTGGGGCATTGTCTTCTCTGAGCAGCAGGAGAGCATAGGATTGCCTCTCGAGGAATGCCCAGTTCCCAGTCTGCCAGCTCTGTCAGGGGCTCAGGCCTGGGGCTACTCGCGAATTAGACAGTCCTCCCCGCACACTCCCCCTTCTCCTCGCGGCTCTTGTGTGTCCTCTCCTGCCTCGTCTGCTGCCGCCTCCCTGTGAGTGGGTAGTTGAGTGTGATTGTGTTGCAACACCCTCGAGTCATATTCTGATAAACTATAATAATTGGTTAGCATAGACATATATTAATATATTGAAATTAAAAAAAT + #)%(-".,/....-,(+--/..+/+,,..--./,*//,-//+/),+/+)+#./$.',/-/+/--.)/.',).*#++),-$,(/).,.-//*-+..*./).,+*)+-.,#/./*-,.-/,+./#.)*--)/++)..//,./*+.%'/+**,*)-/..-..(#,/./.-.+#."-.-%(*)#-/%+./.#,*//%--$/.&/).+-.%.*.--(*...++-/,+./--./+)-.+%.,.+#--,,)%$...),,#$&,'+%.+.$)*/../--'*/%#/...*,).)#/(*)...++&....&-'-..*(..-)++./,.$.)(,.,,,.-,'--/.&/,-/--,*(/./.)$)./))),*(,.(--,&%,(&&-(&$%*,&-.).....-('+#-$-*.(-/"..-+,*,'+.)-.'-)'+,"+-..#++.)'-#./,-.*),#,..+%--&)..,".+-&+&&+#-..'%,..*),,/,+-"/,,.&()*'&.+&--',)*(((-(--../...,,..,,)'),//%../.#.+-+/."++*,/+**./..--%&,-.,*/.,./../*,-%-.*-.)(/-.'-(/*('(.-)/+*-+'*$-,(&(-*-.)-"-"+-'...*%-(&))-//+.//,".-%,....#.&-"-,/-///'.),-#..",*.///-.*/-)#*+,)"*#+.+,,/+*-,//)+/./,*/,+)$*'+)%%-./*/'%./.-%,//+,.*.$/-,./#-&&*)%,-.+.-+(+*"..,+.)$.*".*/.+#,(',-/*+./*,,*--'/+--//+.&/+//&-..),,#/..)')#.'",,.*/&./*&-.*"-$'.-%),...)"*+'")&$-#,+,./,*..,+()%)--)%,.-,$"#*)+*--((%#-*,/"/&(..+*/,,..#/")....'%'/+..-,%-(+-,-'"+-,-&%-,'+)+..+,..-#-*')+.+-.,-.-,,+./...++%+-.-'.(/,-..#$&+&+&',("$(&&,..-*(#/'....&/.&---#+-%).),"+./,--..../+.*./&.-/*-.+).-/++(#..+#+&...#)(.)'))../"-/*/-'-.*)(-+'.,%,///"-.'.-+'&$.++./+-/&%+-#///,../../..&,*"/..&."+%,'(''+.%&&*&,,*$#*(.,,/..*-.*$$$-.+(*+$//,+*//&.-...*""../.-",*-./*"/./-*-(,-,)+,,..&,.,./.&-*"*.##,'*.*'-.-#.-"&..*(()./.&..(+.,/,.#..*-*"+.&-)-+#/-,,./,/,.#%'#'++*+#&**,-.-,--"-#//*/*.../..#/)/.++-(///)).,#.+&.-#/,/).-+/+/*,-.),--++.)/-..++.&--$*.#.-#.-.,*,..-..,$%**+...,%+*%.-&&)$*.../-*-,"+*(."+...(+,/.,+-,.-,*$.(..+%*-././//*,%+.-.)//.$-/++."--+,-,-./&.-"...,*.....+))-+,))*-.)#-,#.*-.//,./#/(//$/..%#-,#.%-.$'./-.*-**/)+)"$+')((%,#&-++------,'-,--&&'+*&-/),...,%(**"--,#*.)-+).-,,#..,--,'*(),),--&)')&#'$,+)(%'*')$(&'%%)(#(''&)*)(#***&*),.)/+/.-.).,+.++),.-(..+)-,).#-.'-.+-.....).-+.).-)----,,....-(,,).-%-,..*-),----.-.'%+#+&"$,*#.*-+*&$"##&"#%&#(")##"$$'#$%%%%%%$& @rCer/1102/1493_57_CCS TTAGGTGGAGCCATGATTGATGGACAGTCAGCTTTTGCCAATGAGACCCTCAATAAGGCTCCTGGCATGAATACTATAGACCAAGGGATGGCAGCACTGAAGTTGGGTAGCACAGAAGTTGCAAGCAATGTTCCAAAAGTTGTAGGTTCTGCTGTTGGTAGTGGGTCCATTACTAGTAACATCGTGGCTTCCAATAGTTTGCCTCCAGCTACCATTGCTCCTCCAAAACCAGCATCTTGGGCTGATATTGCTAGCAAGCCTGCAAAACAGCAACCTAAACTGAAGACGAAGAATGGCATTGCAGGGTCAAGTCTTCCGCCACCCCGATAAAGCATAACATGGATATTGGAACTTGGGATAACAGGGTCCCGTTGCAAAAGCCCCCTCACAGGCTTTGGTTCAGAATATAGGTCAGCCAACCCAGGGGTCTCCTCAGCCTGTAGGTCAGCAGGCTAACAATAGCCCACCAGTGGCTCAGGCATCAGTAGGGCAACAGACACAGCCATTGCCTCCACCTCCACCACAGCCTGCCCAGCTTTCAGTCCAGCAACAGGCAGCTCAGCCAACCCGCTGGGTAGCACCTCGGAACCGTGGCAGTGGGTTCGGTCATAATGGGGTGGATGGTAATGGAGTAGGACAGTCTCAGGCTGGTTCTGGATCTACTCCTTCAGAACCCCACCCAGTGTTGGAGAAGCTTCGGTCCATTAATAACTATAACCCCAAAGATTTTGACTGGAATCTGAAACATGGCCGGGTTTTCATCATTAAGAGCTACTCTGAGGACGATATTCACCGTTCCATTAAGTATAATATATTTGGTGCAGCACAGAGCATGGTAACAAGAGACTGGATGCTGCTTATCGTTCCATGAACGGGAAAGGCCCCGTTTACTTACTTTTCAGTGTCAACGGCAGTGGACACTTCTGTGGCGTTGCAGAAATGAAATCTGCTGTGGACTACAACACATGTGCAGGTGTGTGGTCCCAGGACAAATGGAAGGGTCGTTTTGATGTCAGGTGGATTTTTGTGAAGGACGTTCCCAATAGCCAACTGCGACACATTCGCCTAGAGAACAACGAGAACAAACCAGTGACCAACTCTAGGGACACTCAGGAAGTGCCTCTTGGAAAAAAGCTAAGCAGGTGTTGAAAATTATAGCCAGCTACAAGCACACCACTTCCATTTTTGATGACTTCTCACACTATGAGAAACGCCAAGAGGAAGAAGAAAAGTGTTAAAAAAGGAACGTCAAGGTCGTGGGAAATAAAAGGCAGTTCTACACAGACTGCAGCAACGGTTGCATCTGCATATCCTAAGAGGAAAAAATGACCTTCAAGAGAATTAGGACTTTTTTCTTAATTTCACTGACTTCAGAGACGATTGCAGACTTGCAGTTTAAGTATTGGAATTTCACAAAAGACATAGGACTTAACTGG + 3#7:8=88:<=1=::98;=76;8:=:5:558,*,:/8332319?6;9<,;227>;:145867,>;:96998<6=893<5898;>196:>17:+0:16>;3<7:4967804=6<;)81;4;:9>>3;:8878<;:9:>61:68;9;79:99<9+5;471605:/583674726=..9-4>>;:==79;:>>;,789*'&6-8;=22>==<=8>>?;7>88<25750668?<8671261372;69:5-*07&<92291<;8;63478623289,847.83576/:7834$582/5249<966420+6:96902;>;;62;:9<:81.;>67/38760.2=61;3;29=9<<9/,.6/,';6/.6-51+05,2:8<86;594618=+65.171890.97878<84325.66699=844::068618<>9==6>8849-6116<78=<661+:=<===::>.7:8>=5:646=58<973=6?54489:;+8;5;96>5;897:8:95:2+--./-.&0,*0,&6/1001.11558295.;;.7:814:.04;;48,::3781::244:83;<=><657544,7698;;=:8846,978946342('.7310918>2?9/:=7<;>79307:<;05260/5=56>;?=778>9?;>:7>>:<<-===;6056/5:>;84.<=676>9:38<2>7:76*45<==973<0;,79/4047879/34:;8;9;;;6;;>164565>3769,79:5::63:88:49:67;.=9679:34--/47753726469+257785498:82559::*.+585<7>;3739833110./164419:;5;<479)99:88+7:928664>=:2;=::;4/.;=3;;;75=<99;<=3;:3768&;644778'9423138452583249:611-3449;489663432282+322./32:96379:+4174755*351459:40'6:996551827-3./(8*1434)0/#4453*64)%%(6543*31-64+564,-54/23).212(3--/5655,$+,,,3//030%)).%33/+/,100402*/1++,)4-*+'3066616035162.(/1-4550*.,*625344200(/1,505014444410636652$0330/+,240-1.0-55664255/5652436-)+$0(-+.3&.066443422646641,- @rCer/1105/2384_62_CCS ATGGGGTATGCTCGCCCAGCTCTGCCTTTGCACCTAAATCCTGGATGGAAGATAGCTTGAACAGGGCTGACAACATTTTTCCTTTTCCGGATCGCCCCAGGACATTCGACATGCACTCACTGGAGAGTTCACTCATTGACATAATGAGAGCTGAAAATGATACCATTAAAGGTCGTCTAAACTATTCATATCCAGGATCCGATAGCTCTCTGCTTATTAATGCAAGGACATATGGGCGAAGGAGAGGTCAGTCTTCACTGTTTCCAATGGAAGATGGATTCTTGGATGATGGCCGTGGGGATCAACCTCTTCATAGTGGCCTGGGTTCACCTCACTGTTTCAGTCACCAGAATGGGGAAAGAGTGGAACGATATTCTCGCAAGGTGTTTGTAGGCGGATTGCCTCCAGACATTGATGAAGATGAGATCACAGCTAGTTTTCGTCGCTTTGGCCCTTTGATTGTGGATTGGCCTCATAAAGCCGAGAGCAAATCGTATTTTCCTCCTAAAGGCTATGCGTTTCTGCTTTTCAAGATGAAAGCTCTGTGCAGGCTCTCATTGATGCATGCATTGAAGAAGATGGAAAACTCTACCTTTGTGTATCAAGTCCACCATCAAGGATAAGCCAGTCCAGATTCGGCCTTGGAATCTCAGTGACAGTGACTTTGTGATGGATGGTTCACAGCCACTTGACCCACGAAAAACTATATTTGTTGGTGGTGTTCCTCGGCCATTACGAGCTGTGGAGCTTGCGATGATAATGGATCGGCTATATGGAGGTGTGTGCTACGCTGGGATTGATACTGACCCTGAGCTAAAATACCCAAAAGGAGCTGGGAGAGTTGCGTTCTCTAATCAACAGAGTTACATAGCTGCTATCAGTGCCCGCTTTGTTCAGCTGCAGCATGGAGAGATAGATAAACGGGTGGAAGTTAAGCCATATGTCTTGGATGATCAGCTGTGTGATGAATGTCAGGGGGCCCGTTGTGGGGGAAAATTTGCTCCATTTTTCTGTGCTAATGTTACCTGTCTGCAGTATTACTGTGAATATTGCTGGGCTGCTATCCATTCTCGCGCTGGCAGGGAATTCCACAAGCCCCTGGTGAAGGAAGGAGGTGACCGCCCTCGGCATATTTCATTCCGCTGGAACTAAAGGATAACTACAGTGCTCATTTTCAGGCCTCAGAATAAGTGCACTCTTCTGTTAATTCTGACCCCTTCCTCAACCTCTTCACGCTGGCATGTCCTTTTGTAGCAGTCTGTAACTTAACTATAGTATAATGAAAAGAATGACCTATAATATAGGTGTTTTGTAGATTCTTGTGTCACTGCAAACAATATGAACTCCTTTTTCGTATTGCCATCGGATTGCATGGAAGTTTTATTCTCTTGTTTTGCTGGAGACCAAGAGGATCCAAACTTCCTGCAACATTTTCTTAGAGGAGAGAGAGAAATATTAAAAGAGAAATGAAACAATAGAGTATTTTGGGTTTTTAATTAAATTATTGTTAATAATATAACATATAAGAATACTTTTATTAAAAATAACCATGCAACAATAACACTATCGTCTATCTGACAGTTTTTCCCCCAGGGAAGTGCTTTTGCCTTTTCTTTCTTTCTCTTTTTTTTTCATCTTTTTTGTCTCTCTCTTTTTCCATCCCTTTTTAATTTTTTAACAGCAATAGAGGAAGTTAACAATTTTTAATGGAAAGAGCATGTTAGAGCAAACAAATGCATAAGCAAGATTGAGCAGCATTATAATTAATTTTCAGGGTTTTGAGGCTGAACATAATTTCATTATCCCTCAAAAAATTACCACCACATCAGAAAAAATAAACAACAACAACAACAAAAAAAGTAAAGTAGGCAGAGCTAGGTTTATTTTCTCTTAAACAATTTTTAAAATTCAGAATGTAAAAATTGGGTAAATTTACTACTGAGAGGAGTGCACTTATTTATTTAATTTACTTATCTGGTCAAAGCCCCAGGAAACCTACCAAAGCTAGAATTAATGACAACTGGTGGGAAACCTAGCATTTCCTCTCCTGAAGAACAAATGTATAAATTTTATTTTTGATGTTTATATATAAACTCTATATCCTAATTACTAACACTCATCAGGTGTCAGCCTTTGCTCTCCATTTTGACGTTAAAAAACAACAGATCTAGAGATACCTCAAGGATATAATTTTTGATTTTGTGTTACAGTACACTTGTAGCCAAAACTGGAAGACAAAACCAATATATAATTTGGCTGCTGATTGGCTTACTTTTAGATTTAAAGTTACTTTGGGTATCCTGTAATTTAGTTGTAACATAG + JJKHG@BHGJEHHHKHIK:JDKHJHHI7DJGJKGJHHEGC=CGKIJJBHHCE@H1JKFKJIKHKHBB@@KGBIJCIIHHF@GC>IGFKDGICDIKBKJJCJI?FKJHJ9E>I@CJ=EIHHKBJF8DJ?JIKKDDHKJEADGD-;7IK=H7GHGFHFI7KIKAJKGCDFGGJIJI;HG4ECEJJDJKHI@GJHCJ=DHGKJH:IGGFJGKIIGA4I?ADG6E8IKIGAJJIHIFFDBJCJIEKB=>E>FD>K?FIFEB8B:HJH3AHDHKG;GFCIAAECBHKE>0DACJJIEB;J@KKFA9H@KJGG@@FA6GJEFHBIJJKI=CHGFF576C:H9CID6FJKID@6GI2GDDJB3GICA=8EJ:C?@IIFEGBIHG?EDEJGCK:77%1>46'9=?=DCGDKH>GJ9GDGEH:IJCK?HKJEIAHFK<8HK>8JID&IEIJJJJE@GC8FI9?<@G5?HJ?JBAGKGJGIIIIHHGEAAGC@IIDA7AIGJBHK>JJHJDFIAB6=>GBBHJIEIB7<3?B>>>A91=I5FFF/@D7CEHHBH@ID>G@DGFHEE7F+BJIBJHFDCC=7<=1>C>A.BIIII>?DD8CHAIB=DHHDFD;FKJ?IEBI6EKIIJKJG)AEC@ID@CG;HD*H8@F?BG;JG8>EH?3;=F8EAAB=>><8:>??9;=;AG>C@GKJHIHD;EIFIB>H9HHIFDIKJFBIKBHIECJJKGC7;EIIBK7DGBGACG>JIKJB?>ECKKKIKJE6D:IJK=BGKC7DH:EGDCCKI@EI0JG@EKKH2I>KGKKCD?FHHBK?J;@D38,8KBHEKF@D@DIDJIJKKJDGG<44KI%:JIIJJKJ>IF>I-HIH2KFKJKJJK9;IHEKJI,DJF;@HK;BFJ+HDJJJIE@BC:CIGJJJI==3I>E6JG/GCDIH:HIFIG@;EA==G-@AJJ/EHIDBA=9GI>9=>@#HKJ5ICDGIKFJIDEJKG,A5>?7ECK>HKEJDABIDHIHH;J;I8>;/;HHCKFE7HHJHFHCC,CD>??FG29A>+DAJIF3IH@CG=7CEHCC>6A0EFHKIHHDKHF@?9$5HKI:IBA=@BBDA>0@C?B@:EA=G>KK>EBJIDDIK*JEEGJ;DHHGG8F;9@HKHIDKBGEIEADKBHGE>AD89>>C9;FEI,EFA>?+FC@HGFFHE8FIICJGI@HJIIHHE.CJKEH0DHBKIH6A>76@KGGB7HBBDK>HG@I6>:(8==CC=IFD7JG69JJ?JBH=HJFHG @rCer/1108/0_1663_CCS TGTTAGCAGAAGTTCCAATCGATGGACAGAGCTTAAGACTCGTGGGACCAGGCAGCAGCAGTCTGCTAAGATAGTACTAGTCTCTGGGACCCAGAGAGTCAACTTCTCAGGAGTAGGGAACATCATTAAGAGCGCGTCTTGTAAAGGTGGTCATCTCCCTTGATCTCACTTGGTCAGATCCCTTGAAGTGCTTCCAGCGTCAGGGAGACCCTGGTGGATCCACAGTGAGTGGAAGTTCAGTTAACAGCCTGGCTGCAGGGCAAATATCCCATTGGAGTACCGCAGCCATCAACGCTTGAGGTCTACCGATGAAAGTAAACAGTGCCAGCTGCGGCCAACCGGTTCACTGAAGGAGGCGTTTGGCTCGCCCAGGTGGTCTCAGAGGTCACCTGGTTGGTGCCACAGTGCCAGCTCCAGTTGTTCAGAAGGAGCCGGAGGCAGCGCCAAGTTGCTCCTATAGAAGCTCGTGGTGTCCTTCCTGAGAATACCTGTGGCCCTCGTGTGGGGAACCTGATCGTCTAAGTGTACCAGTATAAGGAAGGATGTGGCAGAGGATGGGGTGCAGAGGGGTAGCTGTATGTCCTGGGGTGCCAGGATTAATTATTCACCTCGACCTGGTATTTAGTATGAAAGAGCACGAGTTTTTTCAATAGGATTAGTATTCTTTATTTATCCTTTTCTATTCAGTGAATTCATTCCTATTGAGATTGCATCGATAAGTAAAGATGAGGATAATCGTGGATGATGGGAAGGGATAACCGCTTACCCAGAAGGCACTGGGGTGCAAGGAAAATAGCAAAGCCCGTGGGAAAAAAAATGGCTGACTCCCGCATCGGCTTTGCAGGTGATGGTGGGGTATTGTTTTTGTTTTGTTTTGAGACCAGTGGCTTTGCTGCTGGTCTCTCCCAGGCTAGGGTGTCATGTGCAGTGAGCTTAGGCTCACGCGCAGGCCTGGCCCTCAGCTATCGGCTCAAAGCTATCTTCACCTCCCAGCCTCCAGAGCAGAATGGGAACTACAGGCATGTGCTGTGATGCCTGGCATTGATTTTGTTACTTTTATAAGAGATAGGGGTCTTGCGCATATTGCCAGGCGGGTTTTAACTCCTGCAACTCAGCGCAGTCTGCCTCACTTTGGCCTCCCGAAAATGTTGGGAACACAGGTGTATAGCCTACCGCTCCCAGCCAGCTCACTGTGTTTTGCTTTTGTTTATGCTAACTTTGGTTGATGTTAAGGCCACTCATTATTGGAAATATCCAAGCCACCCAGGCCTTTCTAGAAAGTGTCTGATCACTTGTCATAGTTAGTCGTTCTATCTCATATCAACCAATGGAGACGGCATCCAGGGATTGGAAGGATAAGTGACCACCCGAAGCGCGAGCTGCCGACGGATTTCTATGAAGGCTCTATCTCTAGGGTCCTCCCTGCTGAGCAACATGACACCAAGAGGCGGGGTGAGCAAGGGAGCTGCTGCTATGCCTGGGTGCCCAGCATGGTCTGTAGAGAAGAGTTCTGCTGTTCTCCTAAAGTCAGTATGTTTTGTGACGTTGACACAGTTGAACAGTTCAGCGAAATCATAGGGCTGCGTGGAGAACTCCCTCCGGTTGTTACAACAGGTAATGGAAAAGCTAGAGGCAGCGACATTAAAATAAAGCTCACTGTTAC + **'$#'%&+',-(-).'.--,,#%&(''"$$'#'$#$($(%%&##(#&*'*(&#)&$'#"(($&*+'&"&$$$###%"#(&%!""&%#$#%,,&"$")+#%--,%))%''$"#)&&&'#&''+&%&,','%$#%"#$($(#%#""$$$#%#"%'("$%+))$#,+-'$,-+++)%)'"#%%&&'-#&,'$$#&$)#(-'%'&((&'("%%,-')-%*-&$&'+#$,&#+,'+&#-++/.."-)//..&/*++''-'&++%.%''-#-"+..""-*..#-*-+##&"-.".#+...#$#-.---+-#-"-#-&#-,#)'%*-.$-(+#"./..)+*,(.+.-&%.(.%$-*/.,..)//.&))&,","(+...-.''+,"/.--,%,%%&.-,,+,()"*)&(//.,.(/..*"+..%+%'+".,+*",(-++&.,.-%/../&'.#..,-",').*.$(()+".//./-./-#*.)$*/..".).##+.#%%+*(&--""-,#&&&*)%+/-/-#/.../)//-..",/.."'"*#&($$#,).&&,+..($--//+*,..-(...,*'*.&.".-....+,#"&*+,-.,/.,./--*,&#.../.&..,$'+//-."/"*-.%(#&,)#.+(-..#.+--+"")..%./..+.%,.."*,...+/&..'..&&-+).+'),.//.-.).-..&#/+,..-+.&"+"--//,."(-#'+-,*.//,..-''"(-%',-'-'%-.%&'+'(+$(-"(.+,$.-##)+.-,).++/...('*,$&.(..(,+.%"--#%$(.%)..,*+-+&(%%&+".(+.--*+.(++-.&"%,&),(*'.."&+(-*"--+)+,,##(&-%(%'-++(&*-+(.,...(,+-..,.+#*.-,#*)-.)+$+"%**-''(*-,&+..#/.$-*-&.$/,-*--,".*--...#/,...))-%*%)-&-*#".*.#"$,-./,%.+/#/,+,.//,/-)-"..+/.+//..-/'/%/.(-.%#.../.,,//(.&-,).#,/..&/.++/%(#-.-+&---.,.,**,.,&')--.$%)()*-.&-,-(/(,.&"&*.*.+.&(,+'))*'-.)/../)../..././/..'+%(-"--.+*+,((,,*$&-%(*%.,,(*+-&%--/....-.*"'%).#-(-(,-%+...$)....,#....)-'(-./.++&-,-&#/."-)./.+,.%,+-/..*'*..)&,#%"..,."),*-+&-*'&(,#)%"&&$$#(#%$$%#%##)*%"$#%'%)*')')+%&(##(%$%&#%)&$)&$#$&##$$#(%#('$$##"###$"&$$(&',,)&&&(+-,"*&+&+,-,%-,(,+&)%$#'&%#))&*$&",++%*+')&'&$'&)'*'*##((,%++&%$$((*++++'.,$(/../-+'".*&%'#-...,/)/...+-,)+--,%..).,+,&#/--/",.,#,+)./(,,.-),*.,##.+-./*.,...-*.-..##,$/.+.*-'$*/)*,"/)/)-//./-++-./*,/--,.....$.(-,*/./.*///."&+(+-.-"*,*'/-.$"*,+*-*..-%%&$%'+,--/,&./*//.---*/.#-'%(.,.$...&+//$//*+/-)+'(.,-).+..-#-.$+-,- @rCer/1112/25_1831_CCS ATGGGGGACGGACGCAAGATGGCGACGGCGACCATAGCTCTCCAGGTCAATGGCCAGCAAGGAGGGGGTCCGAGCCGGCGGCGCGGCGGCGGCAGTGGTGGCAGCGGGAGACAAATGGAAACCGCCACAGGGCACAGACTCCATCAAGATGGAGAACGGGCAGAGCACAGCCGCCAAGCTGGGCTGCCTCCCCTGACGCCTGAGCAGCAGGAGGCCCTTCAGAAGGCCAAGAAGTACGCCATGGAGCAGAGCATCAAGAGCGTGCTGGTGAAGCAGACCATCGCACACCAGCAGCAGCAGCTCACCAACTGCAGATGGCAGCAGTGACAATGGGCTTTGGAGATCCTCTCTCACCTTTGCAATCGATGGCGGCTCAGCGGCAGCGGGCGCTGGCCATCATGTGCCGTGTCTACGTGGGCTCCATCTACTACGAGCTGGGGAGGACACCATCCGCCAGGCCTTTGCCCCTTTGGTCCCATCAAGAGCATTGACATGTCCTGGACTCTGTCACCATGAAGCACAAGGGTTTTGCCTTCGTGGAGTATGAGGTCCCTGAAGCTGCACAGCTGGCCTTGGAGCAGATGAACTCGGTGATGCTGGGGGCAGGAATATCAAGGTGGGCAGACCCAGCAACATAGGGCAGGCCAGCCCATCATAGACCAGCTGGCTGAGGAGGCACGGGCCTTCAACCGCATCTACGTGGCCTCTGTGCACCAGGACTCTCAGACGATGACATTAAGAGTGTGTTTGAGGCCTTTGGCAAGATCAAGTCTTGCACACTGGCCCGGGACCCCACAACTGGCAAGCACAAGGGCTATGGCTTCATTGAGTACGAGAAGGCCAGTCGTCCAAGATGCTGTGTCCTCCATGAACCTCTTTGATCTCGTGGCCAGTACTTGCGGTGGCAAGGCCGTCACACCGCCATGCCCTACTCACACGGCCACGCCTGGAGGCCTCCACCTGCCGCTGCTGTGGCAGCTGCTGCAGCCACTGCCAAGATCACAGCTCAGGAAGCAGTGGCCGGAGCAGCAGTGTTGGTACCCTGGCACACCTGGACTGGTGTCCCAGCACTGACCCTGGCCCAGCCCCTGGGGACTTTGCCCCAGGCTGTCATGGCTGCCCAGGCACCTGGAGTCATCACAGGTGTGACCCCAGCCCGTCTCCTATTCCGGTCACCATCCCTCAGTGGGAGTGGTGAACCCATCCTGGCCAGCCCTCCGACGCTGGGTCTCCTGGAGCCCAAGAAGGAGAAGGAAGAAGAGGAGTTGTTTCCCGAGTCAGAGCGCCAGAGATGCTGAGCGAGCAGGAGCACATGAGCATCTCGGCAGCAGCGCCCGCCACATGGTGATGCAGAAGCTGCTCGCAAACAGGAGTCCACAGTGATGGTTCTGCGCAACATGGTGGACCCCAAGGACATCGATGATGACCTGGAAGGGGAGGTGACAGAGGAGTGTGGCAAGTTCGGGGCGTGAACCGCGTCATCATCTACCAAGAGAAACAAGGCGAGGAGGAAGATGCGGAAATCATTGTCAAGATCTTTGTGGAGTTTTCCATAGCCTCCGAGACTCATAAGGCCATCCAGGCCCTCAATGGGCGCTGGTTTGCTGGCCGCAAGGTGGTGGCTGAAGTGTACGACAGGAGCGTTTTGATAACAGTGACCTCTCTGCGTGACATTGGCCCTCTCCTGGACTTGCACTTGTTCCTTGTTTCCTCTGGGTTTTATAGTGATACAGTGGTGTCCCCGGGCCAGGCGCACTGTGCCCAGCCCGGCCTATAGTGCGGATAAAGGTGCGGATGCTGCTGGCC + KK+KKKKKKFKKKKKCK7KK-KKJKKDKKKKIKKKKKKKKKKKKEKKKHKK$K*KKIKKK@KK3KKKKK&KKKI2J>KK1KK$;&KK&KK1KKK>K:KK,KIJKK*KKKKKKJKKKKKFKKBKKAKKKK0KKKKKKKKKKKKKKKEKKKKEKKHKKE>KKKKKKKKKKKJ:KK1KKKJKK/KKKKK4KK&KKKKKKJK)KKKKKKKKKKAKKJK&KKKKKKKKK>K-K?KKKKKKK.IDKKK6KKKKKKKKKKKKGKKKKKKKKKKKKKA>KKKKIK>KKKKKKKKHDKKFKJKGKKKKKJKKI%J?I/KKKKKKKHKKKKKKDKKK:GKK@KKJ@KKEKKKKK3KKKKKKKK)KKKKKKHKKKKKK.KJ2KKKKKKJ2KKKJJ9KKKKKKJK0KKKKKKKKKKKFKKKDKKKKK=KKDK;KKKKKKKJJJKKKKK,KKKI2KJ:A,KKKKKKKKK-K5KGKKK?KKKKKKBKK(KKKKJKKKKJFKDKKKHKKKK:KG$KKJKJKKKKI)KKKKKKKKKJCK9KK,KKKK8KKKKKKJKKKKKK?KKKK.KKKKFKKKKKKKKKKKK>K,KKKGKKKKKKKKKKKKKK8KKKKKKKK3KKKKKJ?KFKKKJKHK2KK(KKCKKK;KKKKKFKKKKK0KKKK7;/KKK:KKKKKKJKKK2KKKKKKKKKKK/KK-KKKK+KK*KJKKJKJKKKKKKKKKJK4K+KKKKKKKKKKKK%KKK='KKKKKKIKKI(HK,KKHKGKKKK-KK>KKHJKKKKHKIKK3KKKKKKKKKKKKK-KKKKK4K?KKKKKKKKKKKKKKKKJKJKKIKJKKKKJGKKKKJKKK@KKKKKKKKK0KKKKKKKKKKKKKKK2KHKKKAKKHK3KKKKKKK1KKJK;K:K8KKKKKJKJKKK;K+JIJKK6KKKKKKKKKKKKKK'KJKJKKKCKKKKKKDKKKKKKKHKKKKKKKKKKKKKKJK,80KKJ@J,KKKKKFKKKKKKKKKJK6KKKKCKKJKKKK4KKHKKKKKKKKKKKKKKEKGKKKK(KK'$KK4IK2KKKKKKKKKK'KKKK5KK3KJKKKKKKKJIKKKKKKK&K;DKJKKKKKKKKK6;(K @rCer/1113/0_1217_CCS CGGTGCTGGACTGTACAACACCTGAACCCCGAAGCATCTGCCTCGCCTGCTGCGTGCCCCAGGACCTGGAGCCCCTGACCATCCTGTACTATGTTGGAGGACCCCCAAGGTGGAGCAGCTCTCCAACATTGGTGGTGAAGTCTTGTAAATGTAGCTGAGACCCCACCTGCGACAGAGAGAGGGGAGAGAGAACTGCCACTGCCTGACTGCCCGCTCCTCGGGAAACACACAAGCAACAAACCTCACCGAGAGGCCTGGAGCCCACAACCTTCGGCTCCGGGCAGATGGCTGAGATGGAGGTTTCCTTTTGGAACATTCTTTCTTGCTGCTCTGAGATCATGTGTGTAAAGAAGTGTGGGTTTGTTAGAGGAAGGCTGAACTCTTCAGAACACACAGACTTTCTGTGATGCAGACAGAGGGGATGGGATAGAGGAAAGGGATGGCAAGTCGAGACGTTGTGTGGCGATGGGATTTGGGCTACCCTGAAGGAGGAGGAAGGCAGAGAATGGCCGGGTCAGGGCCAGACTGGAAGACACTTCAGATCTGAGGCTGGATTTGCTCATTGCTGTACCAAATCTGCTCTAGGGAATCTGGATTATGTTTATACAAGGCAAGCATTTTTTTTTTTTTTTTAAAAGACAGGTTACGAAGACAAGTCCAGAATTGATATCTCATACTGTCTGGGATAAGGGTAAATCTATTACTTTGCAAACTGTCCTTACATCAATTAACATCATGGGTCACTACAGGGAGAAATGCAGGTCATGCAGTTCCTAGGCCATCGACTATATCGGGCCGTCTGGATATGCTGAATGCAGAAGCAAGGGTGGGAATGAACCCTCTCCTGTCTGCCCTCTGGGCCCTCTCCTCCCCTCTCCTCGATCCTATTTCCCTCGGACACTTGGTTAGACGCCTTCCAGGTCAGGGTGCGCATTTCTGGATTGTGGTTCCACGCAGCCTTGGGCATTATGGGTTCTTCCCCCCTTTCCCTCCAAGACCCTATGTTCATTTGGTCTTCCTGGAAGCAGGTGCTACAACATGTGAGGCATTCGGGGAAGCTGCACATGTGCCACACAGTGACTTGGCCCAGACGCATAGACTGAGGTATAAGACAAATATGATAATTACTCTCAAATCTTTGTATAAATAAATATTTTGGGGAATCTTGGATGATTCATCTTCTGGAAGATTGTTTCTAGAACAGTAAAAGCCTTATT + S$+&*'%#)(,'+&',',)%"$+,)-',-($')),),*+*+*#%*&###&(+$#)-(**'((-,))$&'(((&('#&''*'())+.&'$&+)()))-)+*'&,,0,-2+1&+0*+.*$&+-0-,%(+*%&,0%--,,.5//4*122463524)2.2101*++00/33350)051(.-(*.',2/102/022,.'/.556/+**.4+0.1*/34//%232&0++6551.04350104/*2/46/*$02-)41'1)4/11/+(/().+.0/254/201.1,)4-/41214+(,+54)-(,(+)/,&'#%'-%*$*(#$*'*./2)-/,-$-+-*(/,#*1*$%(/&''#+*%%*,/.0(0/&.-/%,,*.-.+/02521,3015*01/5&.-2(-0-0++(42.14104,,++(35/2+#*0,,-&+/*).12,1&/)(511/335.4.+.140,4204./4./55154-641).0-,4/,/)2204+)$/0.2-+30/$1000*.)+..6(0(1'%,%%+3(4,*.20(0'120432.33(/1+34235512262*/02,--++2-(,05++0%,/3+151414/&*#+62-.*5506002)2/4)//12.4)-/11/'--/010.2-/+//.'&*1.),10*+'0*2/-.*32&00-&1-*2//53%'.4155'&02/1/41%112%)0*354+1534/-*554%4505.55/164*/.#.*420)-+,220-(//0'2/,5443121-20--%///4//(1150+-03255162/12-62211)3314135)44/24*31+./11)4.-314155-0-054'3+,113652425(1)12555-.25+)/0(2/.1/*/.%14)&)$)-.166/./(5001651542/2/%2-/-,5.-*.*.56,555165*2),*11-/*/)1634/0/..)*.13363.0/-.1+3+0400./0-1()'24'.15,4536222(3+21012%-$(.0426565/'45/'11)-1+&*)02,.*++/.(-.3,4620+45----.3/-)%',-,32(.(#)+('//,*1/-540.14011*/2.,-.4/)1-3-2/,11203-130220,.+.&/($,).1)/14-.4'*,.*4/1*.-.$,//31226351-03.+/-)(%****/.//2.5.305-.3,$2)&-2&00.430510&20'344.30/3*4/-%//-1/6/24.5 @rCer/1115/25_2260_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTATCAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTGTTAAGATGGCAGAGCCCGGCAATTGCATAAAACTTAAAACTTTATAACCAGAGGTTCAACTCCTCTTCTTAACACCATGACCACGATAAACCTCCTACTTATAATCATACCCACATTAGCCGCCATAGCATTCCTCACACTCGTTGAACGAAAATTACTAGGCCACATGCAACTACGAAAAGGACCCAATATTGTAGGTCCATGTGGACTATTACAACCCTTCGCTGATGCCGTAAAACTTTTCACTAAAGAACCCCTAAAACCCGCAACATCTACCACCATCCTCTATATCGCCGCACCCGCTCTAGCCTTCTTCATTGCCCTCCTCCTATGAACCCCCCTCCCCATACCCAACGCCCTAATCAACCTCAACCTAGGGCTCCTATTCACCCTGGCCATACTCAGCCTAATTGTCTACTCCATCCTATGATCAGGATGAGCATCAAACTCAAACTACGCCCTAATCGGAGCCTTACGAGCCGTCGCCCAAACAATTTCATACGAAGTCACTCTTACTATTATCCTCCTATCAGTCCTACTAATAAGCGGCTCATTTAACCTCAACACACTCATTACAACGCAAGAACATCTATGGCTCCTCCTACCATCATGACCCCTAGCCATAATATGATTCACCTCCACACTAGCAGAAACAAACCGAACCCCTTTT 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rCer/1116/0_1459_CCS TGGCTCCTGCATGCCAGGGCAGCACGGTCCAAGGCAAACCACCCAGCCCCCCACGGGAAAAGAACAAGAAAATCAAAACTCTTCCCTTGAGGAGCGTGACTCCCTTCAGCAGAATCTCCAGCCAGTGTTCATCGCTTCAACTTCCTGGGACGGAGAACATGAAGAGTGGCGACACACGGCAGCCTTTCTTACTTCCAGAAACTGCAGCGCGCGGCACAGCAAAGCGCAGAACAATGCGGGCTGTGCATGAGCACGGCAGAGGCAACCCCCAGAGACATTAGCAAGCAGTCCCTTATTATCAAATTGGCTGCCAGCCAGGGCCACAGCCTGGCTCAGTACCGCTATGCCAGGTCCCTACACAAGACCACCCTTTGGGAACCTGAGCAGCAAGGGCAGGCCAGGTGAAGCAGCGCAGACCAGGCTTGAAGAGGCCCAGCTTCCCGGGCTTCACCAAGGAGCCCTACCTGGAGGAAAAGAGCGTGAAATCTTTGGCTGCAGCCAACAATGGGGACTCACAGAGCAGTACCACCTGGAATTGCTATGAGAAAAGGCCTTGGGTGCAGAGGAATCTGCGAGAGGCCTGGAGTTACCGGCAGTCAGCACTCTGGGAAATGAGGCCGCCCAGGAGAGGCTGCAAGCCCTCTTTTCCATGGAGGCTGCCAGCCCCAGGGCCCAGCGACCTGACAGTGACAGGACTGAAGTCTTCCCAGCCCCTCCCTCTGCAGCTTGAACACCCTGCTAGCAGGAACCTCACGCCTACCACATGCTCGGCACAGGGAACTTGGCCTCCTCTGCAGAGTGGGCATCTCGGAGCCAGCTGGAATCCTCCAGCAGGGCTATCTCCCACCCCCCTACCCACTGGAGGAGTGTTGTAGACTAGGTTTTTGGCTAAGAACTTCTCACCTCAGCCCTAAAATGGAGCTGTGGGTTCTCAGAGAGATATCACAACTTGGTCCCGAAGAAGAGGCCGGTTCCCCACCCACCTTCCCCAACCTAAGCACCTGCGCCAGTCAATGCAAGAGAGGAAAGTATGTGAGACCCAGGTCTGGCTCTGCCACTTGCCTGGCCATGTCACCTTGAAGCAGTGACCTGACTCCATATTGCTTCCTCAGTGTATACCAAAGGCAATGGTGTCTGCCTTCCTACCTTACAAGACAAATGCAAGGGCATTTCACACAGAGAGGACCTTTGGCTCACTTTGGCCCAGGAGGCAGTGAGCTCTGGTTGCATGACTTTATAGGTTGTGGGCAGGATGAGGACCTGGCCTCCTGACTCCTGGCCCAGGGTTCTTGTCCATCAGTTCAGACTGCAATTTATGTGAGCATATGACTGTCCTAGTCATGGGAGAGTAAATTAGATTGAACAGGAGTCCTAGAGCTGGAGAGTGTGATTCTGAGGTCCCCGTTTGGGAAACGTGTGCAGAAATGTCTAGGTGTTTAATAAACAGATATTGGATTAT + S''%$$%#%&&",((+&#++)(**#&##'+&,((&$((',&#+(%$'(""(++'"$$#&&$&*+)+,'&$)+')%&**(()&+$&'$(&(%(%$&$(&()%#)#$),-+)**$"$($'),)&#')+,&)#(,,*,(,(&)*')+-'#&(&,(+)(&)**$$$(&''(%'%%%(")+*')'%)(+#&%%$#''"#%+(&$'%#$(,(,))))*'((#*(+,'+,+,),*%#$(&((**$))'%'&%$)*++*+()(+$()$"&)%**-'--)+,-,-),---+*+$'%%%"'##$&''%%%#%%#%*,,*,-.,$+.(%')(-%+(,)**(+*(+*+'+,-',$(*&((+(+%$(&&*'"(&(%(),$$)#$%($$('+&,%')'),'+'#&+*(*$##-("+&&&&)+((&$((('&%(#(*'-,($))&*'-*#(,&)$#"")"$$+*'))(,'(,,(,+(),-&'%#"#%)*)$),+#)&&,'%##""$(("%,)(,-'-,)-'%,,,-,&'+-+)'$+)#&**-*+'$(,)*)-,(*(($))$))$(,(-$(++#-,+$%)),(*"$(*'(*+-(+)(#%#("#&(%)''++(&+*((+')-'$*#%-,*%(&)&(')---)(&)*)--+--*,#(*'"$$$$%(,&%'),,-('($%&((&))(#(&&()((''%&&$''(&&"%,+**.(+())-(,+#+$#%'&"&&&&&(('&&&+,(,%**(+,)%))*&'')*-*$'%+&(#'+,,'+&'(-+(+'$#%($$$%$(',*')$&(*-)-((+),(-,()#&&$)((+*'$''+&'','+'%+,')'#((&)+-*&%&+++&##&$(&##''%&')'((),),*,##*)---)*)*&*)()+,-&-,*+(*-(%($&,%'($&%&&&*(%'%**''(%#%),-+%%()&,(&+))')&(,)($(+%'$%&('&+&$(%++,',('-,((-,-))&)%,))(&)*&'-,)#++*&*&*'#(&&%%'))*,()+,&$')&#),-+%''&'',-''+&)+,$'&(((+-.+'',,-),+,)-,,','(*,)-,-(''%(&&,$$##&'+&*(-+),*,,$((,'),$(,&&)-,-*)$#$$&(&&*(-,)-+)-,*),*)(),(+(+)-,'(,$%'),-,)+'((&',),%*+'')))+'$$*++*$'++(&+&,,&#,),()%')',+.-))*),**,)'+(#)$("&)'(',-*+((&((($"$'')##'(&$)%,$$$#%,,--*$+(,(),(()##(+)')'*+&$&$%()&)&%#&##)(&#()(*-----&&%,,&*-,*#')"#"$&')),&$('$%&('&'--)*&(,*+$&#+-+',,'$"#()%#'')+,'&(),-.-,-,('),'$'&'*(+-,%,,++(--%**',,'&)()&#)*(+,+&#()*%&$&#%$%*$&('%'*)*+'(')($#&$ @rCer/1117/2574_68_CCS ATGGGGGATGTCAGCTCTCGACGAAAATAGAGAGGGATCGCCTGCAAATCCTCAGCTCCGGCGGGGCTAAACCTTGCAATCCCTCCCCGGCCGGCGCCGAGCCAGGGCGCAGCGGCCTCCACCGCCTCCCCCGGCGCGCACACACCCGCACACGCGCACGCACGCTCACCGTCCTCTGCCACCACTCTCTGCTCCCGCCACTCGCCGCACCCGCGAGCCCCGCAGCAAAGCACAGGTAGCAGCGGCTGCAGGGCGCATCTCCGGCGTGCGCCCTCCTGCAGCCCTGGGTGCATCGCTCTCTCAGGGAAGCCACCCTCGGAGCCCCCGGAGCTCACGCCAAGCGCCATCCCCGCTGGCGGAGGGGAGCGCGGGTCGCGCGCCGTGGAGAGCCGGGACGCGGATTAGCGCCCGCAGGAGCCTCCTGCGCCCGTTGAGGCGCTAAAGGGCTTACCCCGGAGGCGGGTGGAAGGGCAGGCAGAGGCTCCTCTTAAATACCGCTCCCGGCAGCACTTCGCGCTCACCCCGGCGCCCGCTCTCTCCCTCGCCCACAGCTGCCGGATAGTGCTGAAGAGGAGGGGGCGTTCCCCAGACCATGGCATCCACGGAAGGTGCCAACAATATGCCCAAGCAGGTGGAAGTGCGAATGCACGACAGTCACCTCAGCTCGGAGGAACCCAAGCACCGGCACCTGGGCCTGCGCCTGTGTGACAAGCTGGGGAAGAATCTCCTGCTCACTCTGACGGTGTTTGGTGTCATCCTGGGAGCAGTATGTGGAGGGCTTCTTCGCTTGGCATCTCCCATCCACCCTGATGTAGTTATGTTAATAGCCTTCCCAGGGGATATTCTCATGAGGATGCTAAAAATGCTCATTCTCCCTCTAATCATCTCCAGTTTAATCACAGGGTTGTCAGGCCTGGATGCTAAGGCTAGTGGCCGCTTGGGCACAAGAGCCATGGTGTATTACATGTCCACAACCATCATCGCCGCAGTGCTGGGGGTCATTCTGGTCTTGGCTATCCATCCAGGGAATCCCAAGCTCAAGAAGCAGCTGGGGCCTGGGAAGAAGAACGATGAAGTGTCCAGCCTGGATGCCTTCCTGGACCTTATTCGAAATCTCTTCCCTGAAAACCTTGTCCAAGCCTGCTTTCAACAGATTCAAACAGTGACAAAGAAAGTCCTGGTTGCACCACCGCCAGACGAGGAGGCCAACGCAACCAGCGCTGTTGTGTCTCTGTTGAACGAGACTGTGACCGAGGTGCCAGAGGAGACTAAGATGGTTATCAAGAAGGGCTTGGAGTTCAAGGACGGGATGAACGTCTTAGGTCTGATAGGGTTTTTTATTGCTTTTGGCATCGCTATGGGGAAGATGGGAGATCAGGCCAAGCTGATGGTGGATTTCTTCAACATTTTGAATGAGATTGTAATGAAGTTAGTGATCATGATCATGTGGTACTCTCCCCTGGGTATCGCCTGCCTGATCTGTGGGAAGATCATTGCAATCAAGGACTTAGAAGTGGTTGCTAGGCAACTGGGGATGTACATGGTAACAGTGATCATAGGCCTCATCATCCACGGGGGCATCTTTCTCCCCTTGATTTACTTTGTAGTGACCAGGAAAAACCCCTTCTCCTTTTTTGCTGGCATTTTCCAAGCTTGGATCACTGCCCTGGGCACCGCTTCCAGTGCTGGAACTTTGCCTGTCACCTTCCGTTGCCTGGAAGAAAATCTGGGGATTGATAAACGTGTGACTAGATTCGTCCTTCCTGTTGGAGCAACCATTAACATGGATGGTACAGCCCTTTACGAAGCGGTGGCCGCCATCTTTATAGCCCAAATGAATGGTGTTGTCCTGGATGGAGGACAGATTGTGACTGTAAGCCTCACAGCCACCCTGGCAAGCGTCGGCGCGGCCAGTATCCCCAGTGCCGGACTGGTCACCATGCTCCTCATTCTGACGGCCGTGGGCTTGCCAACAGAGGACATCAGCCTGCTGGTGGCTGTGGACTGGCTGCTGGACAGGATGAGAACTTCAGTCAATGTTGTGGGTGACTCTTTTGGGGCTGGGATAGTCTATCACCTCTCCAAGTCTGAGCTGGATACCATTGACTCCCAGCATCGAGTGCATGAAGATATTGAAATGACCAAGACTCAATCCATTTATGATGACATGAAGAACCATAGGGAAAGCAACTCTAATCAATGTGTCTATGCTGCACACAACTCTGTCATAGTAGATGAGTGCAAGCATGTTGTATGTGGTCATGATGCATGCATTTCACTTCCACTTGGTCTCTCCATTATGTGGATATCAGTCGTGGGTTTAAGTTTGCACATGACGTTGAGGACAGACAGAAGGTAACTCTGGCAGCCAATGGAAAGTCAGCCGACTGCAGTGTTGAGGAAGAACCTTGGAAACGTGAGAAATAAGGATATGAGTCTCAGCAAATTCTTGAATAAACTCCCCAGCGTATCCTATGGTAAATGATGATTTAAACAAGCTTTCTTT + @C8?FA8=>>?@:@CED@EFCEEFA@.?CF=EDDB5BBGBAA?B>?C2@BAFGFBEDB;G?DD52.088;-B::-@7C8?=?9@>A938:>9889??289>B@ABC;BA<@;@B:FECA@>E<@EB76;9:&A9?@ED5:?4)?@@=?>;:?=;9A@C8BC@?CE@AC<:D>9D/EF<@75BAC@;98=-A0EB9B@:A?B@>>CA>A>?DAC@C8CCAD<<==@=CB*BDB5:@>@3BF@FCFBD8EEE:C?9C?EE?5@>;:<@D@;DFBAE6:*AFC=*@BBGE=C??D?D>(;@@@0*?D78;B@CD@CEF;@@>DE?E6DDC::>F6A8B@D?<=B.C?GBFAG:>??<>D:FC?B@;F6F6;FEB@/5A@A@:@=,BD:G?7?GFFJ>IGICIEAGC>8J@BICH>CED>FAGBFEH?B<9IFEGFF@HIEDCEHEHEDB?@B4GC9?=>CHD>F?CA2<95C@BF>DBEH=?FDCF?7D??D?*@9>:D=D?EHFIGIBACE7DFDG1G@;B=HDEDECDE3B?@@@<:1<1=6HHH;D>2=?7CIIG?H;@:>=:98*<=G?DA>7E?@A=CECB;CFGI/?HGGA?@A7F??>BEHE@DDDC9+CE:HGE>DGFEE-<>C;8=@<>=:F5C?DH8;CHIF?=G;9<+?5E@JGI@:EFADFG7F:CGGGCHGD><D>BD:<=?@38?F<9=>BDDDE>D,F>/@;CF@@EEE@FGBBH@@G1>5621+8?I?B>?=A6B6@ED6;69CC9IHFIIDGGE@DD@B0C?HH8ADCDE0G?@?EEC?:<>A@FD@8F=EH?DDFFFAEEB1B>??FEAAA9AGFC?EC4;::ECB8:D=:?1=JD>AAEDCH7HH;IADA?<<@;BGIIIFAFIE5A8=6DAHEAC<9?;DEBGDF?DGDCE*EDDB@HIC@B=@;ECC>9H=GBEH=B?@CHJGEGCGD)?E9C9F>E8D:*CHG@EE=IGFD>B@@FDBIHIBH7B=DIG4HDCDHGJ@JD@CABCACHI?EB?1FHCIGEC=H;GBG?7@I=;D5BA>>FC>A99GHH@98@HBAH>BB=?D=)A>@1B>;DHECEDFAFF;C=ADA?E7F9@A0??:;B@5;C:HGBFFADBDDBHIIJBECIEBHB88FBDDHDAI6FD;@C>9>@>BC3:4C9GG:CEGC)B;AIHFFF>AA+>@EC1;DG/GBB:A;@BBEH(DIFHEEA:BFE=AAD257A5?3>=A>?;D:7AAAC>EGBGF@DBA6B3@DB8?B1D??=>C7AE;AAE@?@FDCF4>FFBF;:E@DBAA3>EA>FB?A>8;;A:=AD:>FE:DC?B4BBA>D8A:DB?F?;B:>A59==68@8CB92AA7A?8?7>EFA565C%?DC?CAE2DD=;@CE=C=.<8CBGBCA?57E?@;>E;F;CB?A/;B;EG=?5;=>BB9:C=5=:AG?AD8BE5AE9C3A@@5EE=3:GBE@ADEAD=BAA?=B7EDB1BFDDEDDB?AF=CCGAAA@=;:EDF9BGEC??9BC@D=5?>E@DACB@1A?<6=<5D>?=B>AD7=B=AFAA=8B?D@?EF>9B1>=?AF@DB@@FECG?D@B@CG;AGDBA=BB;$68=?>2BC>@CC:EA2D8BDE5C9=6@=:?ECG;5=D::=;==EDDE8CBAB<<96>G?A9CC;F-D@3=@2893/D5>A=9:4>D;D@AGEEE5E@FD9<:07AC>;ACGG0@BB?@69GB1;B@2;*614CECBA@;E@A5@86;;C;:FFC?;BAGF?BFBFFCE;BEA8EEE??F=B1<@EE?F@D@=DA;4*0:BCD>65;?$=@EDCCDDDAACAC=:);BBDBCA;89EFAFA?FEFFB7@AB475996BD;DD4<>;D9AD=5:BC3C>1<=:8@8C.;@?2DED>?3>D9F.E?9HAIH@IH?HG4F.E>EE=IHI1FGHHGIGHC&E=7DEEEHE@FDBDCIJHEA6BHA%;8G<@BD>C*BCCIEB??BGFBHEJF8EGKAJ9JCEAGIJI/GIHEFCJJ@E:HFDKHGKDIKH?JFEHI0EFIE7K@D>IFHHF;GDG7J@H>GCJHFH5G?D5G?G:6GKIIJADHKFBKIAFD2IJBDEE3JI=G1>F5@HHHGDD=IAG@DJHBJKJJ1JGBBDJ7JJBCECCJHIFEGHFJKG;JKBJJ@HIG8IJJJG>@BGAHFCAE2HFJGA8ADA@B=BCC@?>EF:J6ADDFEGH@;ACDDHEFHJ8EF4CGAFD*B>D/FIIE/DCH@FFFCEDDBCBC==BDDDEG?C<<6=C9@;EHCEDC;+:CC<@DDG@>=E9DGDIFGC8IIDCFEJDCIHGGGIADGBEBGJ@DJI@F?DIKGCBIHIJIKIGHBB=A,?CDEAECJDI:GGAJJE=BIBJ@HHKAH?KHGCCB7BA?0?AF:GGA@JJEGG5BGA>GDH@EGCECEEK7@KH2HI@JGEC:@GKKD;BH7HFDC7>CAHJJBIG8JHG@CIKJCIBG72IJJDBHCHKFFJE;KJK=DGFCGHJB7D?:E(BE=;0BBAAEACDED3@>4=HGGJJJ9KIKHI:IBJJ>BJGDE@7KHKJKJJ>KGKCBIJK7FKJ;KKFFKHKKH*JGEJKJ7I?HIFKKE@EHHJKFEEH1IDAGIAK>G@GHDEDCF@CCD?D=.GEGKDADGFIGHBKFJIGCFFCHCGGIIDCJEIKGIKIJ4EGHFDKKE;GHG=FD>?GGIH;HGGHJBAB?F%@DG;JFHIKGGE%ADIJGG.I7,=IH?E9IIAGAIIHAI:KJJDIE;EIEJIHE?HEBCFAGJIDKHKE>BFGIDIAJ4GIFKKHCIJHD5HAE@D788JCKF9H9DE@FD?DDCF=:8EHJIIB>HEHHGJIH8;FH::DEH=GC@9;=JG1EFB:E17CEIIEF92D<=BEGBJJ?FIAG>EEIAHEG?=GDIFCEIC@J;EJIGKDJGDHCHBDHEJFHIJG1DIH?J9DGH@I>BKJ5JCHKHJIBFHD=7ABFIDEF#FCEJKKJJKHB;=FCAHJAEIG@(CJIGEB @rCer/1121/1674_65_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACATCATCAACATAAAACCCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGCAACATTAAATGATCCCCAGCAATACTTTGAGCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTTC + EJKK:GJBDKJKIKIIEI:JKKKJKKKGJKKK6KKJFKK8KKKHKKBKIJFK?KCK=KHEKIKKKKGJJKKKKJKHKIFDJKJJJKKKKJJHFGIKKJJKKKKKIKKJKK)JKHKHKKKKKKKKKKKKKJJJ8JIK9CK.K)CDFKIKKHKKIJKEKKK>KJJIKK:JKJJKKJKJKKAKKKJDKI>HKKJK%CFIKJ7KCKKKKJKJIKJJKGIBJFKH7KJFFJI?KJKKJK9E>F;KFKIJKKHKJJHAKG?HHJKK9KHK>KJHJ7KKK9KJKKKKKKKJKKKHKHHKKKIKKKGKK.KKKGKHKK>IKKJDKKKIBGKKKKJJKKKKKKKBKKKFKKFKKKKJBKIKGKKJJIKKKKKKHIKKKGKK8J:JK5KKKJKKKKK,JKAHKKKHKKK&KFAKK8JIKKKFKKKKKK@&KDKKJIKGKKKKKJFKIKJKJGK>JHKJKKAKKEKKJKKKJKKKKKKIK?K>KKKKKKKKKAKDKIKKKKKGJK?KKK@JKGGJJIJ?EJK;KK?HFIKKKKKKKIJ@KKEJIKKKKJKFCKGIKKHJKKFK2JJKJJKKKKKKAHKIKKJFIDGKKJBIKK@KKJKJKKKK>K@KK8KKAJCHKKFIKGDKJDKKKKCB7KK=KBKKIKK1KKACJK.KKK=KKKKKKKKKJK?KKJKKDKKKKKAKK5KJKKKEKKKBKJKKFKJEJKBKJJKK3IIJJJKKKKJKKKKKJIK@JBKKJD>KFKKKCKJJKKKKJKKKK=KHKKKKKIK-K8KKHKKKAKKKK-KKHKKKKJJJHKKKKIKIJKEKKFKKK3K>KKJKHJBCJKKFIIKKFKKIKKIDKJKKKK)KKJKCKIKJKJK9KHKKK:KKDKKKHKJKGKHKEKKBKKKJKHJKKKK@K3JKKHKKKKKKIKKK&IKKKIKKK>KKKKKFHKHKKIJJK@JKKKKJ%CJJJJJIKJJCKHJJKKKK3KH7IFKJK@KHKIJKIKKKKKJJKKK@KKJHKKCKIJKDKKKJGIIKJJKKKCDFKKKCIKDKJKKKKKK@G=)IJKKK=KIKJJFKIIKKD9KKKKAKJKJKIKIIIKJJKJHK-J3KJK39IKKJGH=KI9GKKK7KHJFGIKK=KKKKG.J?FIJKCKIJHHJKIJKKIKKHEHJKJKKKK?EKK@KKJKCGKGIHAE7HKJIJJKKKKIKKGK@IJKHKKJBIKKAKBKKKKKIKKKKGJKK?JJK2KDKKJGKKFDKKIIJCJKJJKIKKCJKKIKIKIIHA5GKKKKJKBKGJKIJKKKKKKKKKAKKKBCIHJIJJKKBFKKKHGK=6KIJKH@DHGK?JJKKDKK@KKK3K=GKKKJ7JGFFBKKKGKKIHCIIFGKBK?JDJKBJJKKGFJKGFI;J:EIHCKHJIJKKGKJJFHK:KGEC@HEBIHKKIKJK4KKKEIIG@IJKKK7KJJKHJKIJGKIKJH=HGJJKK;IKFIJF=JF9HHI)DJ)JFFKK9EJIGKKGFHEKIFJ?JBKEGIKJC>HKIIGFKIK@K?KFE7@(@JBAJGDIJKIJ3IHFKKJGB/GJIDIFHH0H;J4JIJ@J@JJJJIGICJKH6=6HIBGK7HJKK4HCIEGIDJBAJ=AJDCF;J@KGJGHJ9KKFKI)78I%HIKIJEJKKHJGJGGDDKGGKKKIKGK:KCFJ'EEJKF7JE:FJGDJEEIK:;HJKKFEJCI-JKKE5JJFKJAGJGIDGEKKKDJKAKJKIIKBI@IJFIGKKHKJ7EJFJGJI7KJ&GKGEKJ5JDFFICKJKGJKH:JK5KKFKJKJKCJHK3HK?KJG9KIAFJ>HCJAJHCJFFBHGDKKIF7JKKAKJ-FKJJGD(FKBGJ?IJ0AJKFJKKJKJKJKJKJKKK4JHKKKFKJIK5HJ=KJKIEJKIKBGD;CJH;DG7KK0><<::/=::81=6>>>3=617'><>>=0:3:608653146/6%+87;5=9==78.=975<7+:7<>4977;;:<1.604(;4;;11<663<;9(:1<:/73&;/-260;53=3586:*:;5=7104.5;:=9;2?8*7:=9+:582=9:<:8:::4;74'/8;<9??4=;.,99100=88+9;5<56<=756=9:777+=7<.8;>:??5.22*:798.81;>;-76:071842=8:58.89:<()7<90(92')<';6:>9;7>>;<59879491;;<<,9)1:9)3:>6<1;=:9;9;:=)?90=;1,;989;;7.88;;;*;4623/.4463,.4310(16/5<4;<=75.*933592781:;2<5-76*58.2.9:?:=>8;.360,/146$30,847:41&44<97*&*/681832%3774,85-1*354/31+*0+5023+/155/0<233<3<90940/%63+)-2.47;<6;443./31457(79/43*.016(52,42-51)).70,0%10322'03925/%163-7773;5699<816)*13130+28,0-8937,/).0277:3641&863'6>-.:/456:45;:24*2,13)9%-7(520.268;@%;6;9A@@6A::5?:62(''5:?@A4B9?87<=5???><58973(:,.<5<:;4/78?:888A@76589>;>16:<*60:69:868,301+:A767%7>?8;:7>36'9>=6>5<6:52:C5=?=60194?=,A58B>>8>80062=<9AA?+?BB=;A14*?=<:%@ABB7B::=B<4#(14;:;1642:;:9B;?2<7667&188><==>?@5<>6:1;/27=<8;;+:;-<=>?:9>;6>9B?@@8-=>@2>?B9@5.97&7@@>9<8:.9?:)805'8=516;:36&;A@B:>B@86)AB>A4<<;)8>??1;@/4.&87/<#17?:-5/4$A&6 @rCer/1130/22_1604_CCS ATGGGGTGGCAGTGAGGCCCCACCTTGGTTTGCTCAGCTGTGATGTGTAGTCTCCACACAGCTTAAGGGTTTTTAAGGAGTTTTCTCACAGGATTACCTCCACTCCACTCATCTACCATCAGCATCAGAAAGGTTAATATCCCTGGGACCATTCCACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAGTCTCCTCTTGGCCAGGTTCAACAAATGTTTCCAGGGAACCCTGTGACTTGAGCCTAAGTAGCCAAAATGTATTGAGTTTACGTTTTTCCAGAGGACAAAAGTATTTCTTGTCCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCTTAAAAGGCCAAGTTGAGTAATGTCTCTGGAACTGAGACAGAGCCAGGGACCCATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTGTCCCACCAGAACTCTGCTGCTGTTCATTTCCCTCAGGACCACCCAGGAAAGCAAGTAAGTTGGCCTTCTCATCATTCGATCACCTAATCTCTTGGGCTGCAGGATGACAGCATATATAGATCTCCTGTTTAGACAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAACCACCAAGAGGCTGCGTCATTTTTGAAGAGGATGGCAAGGATGACCCCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTTTGGTCCTTAAACCTCTTGGCACCTGGTGTGGGTTATAAAACAAGGAGCTGGAGTAAAATTGTCCTTACCTCCAATCCAAATGCTGTCCAGGATTTGGGAGCTACCCAACCTGTGGGTATATGGTGTTGGTTTCCATTTTTTTGTTTGCGTGTTTCCAAAACAATCTTGCTTGGTACTGCATGGAAAGTTGAAGCTTTTCTTCTTGCCCGCTCAGGACCACCTGTCTGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTTCCTAAGGAAGATTTTTGCAGCGCTCTCTGGAGCTGAGGGGAGTGGAATTTGGTCCAGAGAAGGCAGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGCAGATGTTCTCAGGCTTCCTTCACACCTCCTTCCCATGGGTGCGGCTGGCAGTACAGTCAGGTTGTGGAGGAGGCTCAGAAGAAAGGGGCACTGGTTCAGCCCCAGGTTTGGTCTGAGACAGGCACACAGCAGATACTATCCCACCTTCCTCTCTTAAGAACAGGCCAGCCACACATATAACCCTTTCCCCTACTTTACTAATATGTCCCTTATGTGGTATCAGCAACGGAGGACAGGCAGACTTACCCCCTGCCATCTGGAGAGAATGTTGTTACTACCCGTAAAACTTGACCACCCCCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCATTCCTTTCTATGTGTTAATCAGTTTCCTTCCATTTGAGCTGTGTGGGAGGGAAGGGCATTGAAACTGTAGATTGTAATCTTGTGCCAACCAATAAAAACCAGTATTTCACAC + EA7F=DCCJH:HJICGG3JHGGIIIKIKHKKIJHJJDFJI;BEKIIKE@I@JJGI=KCJKHDCJAGGIK9KKJH:HGEHE/BCA@03==CFFBAE@HKH?CHGCGGEGHCCIEEBDJF?=@EKD9A:E2A0DHAHEHJJ?6GJJ8GJDIKIBGIKJIBIE?2;KK?HEEGE>D;9@DEB=CDBEHGG9HKI@HKKJKIFI@IJ?@HCGGFJKHDFIJGIHBJKFH?F?KEGJEK0AF@IJEKIJH;KKHK8:KK9JCIFJBHJIHCKKIJJICBIJKGHAF;IKKFHBICKHGJ9KHIJKGGH:>DA:IJI=AIAD?JKI==0>9E@KIK7@;.EC4H@EHAD=HJIB3@8KBCIJHHIIBFADFB-BGE>F9E?AFCGHE@:ACGFIKG>FDHDG7DGC7DEH?ACH=FFH@?FECHHAF-E8IJHB@3@17>>AA@HBI@G?;BIG?D@FBFBFB)>?:J?CJJ4CAG<>C=CCIFCIE<77BH?DKIKJI7KBABHC>KEFFAI7DE=BDJEJHHCJ>5KKKI@/?KH9KJJJJH>JI=:D5@F8CA=DK%FFJKIDI>JKCIHHF9KJIE7JJJGED@JEG@=0C=JB>AJFHEFHKDKJJDJKCEKJ1IKKKDKIJKI=ICABIBDEJGFGC;GHEHB/>CHJGDAI:==D;ECECEJ7FFJ@B>BEFIJI?BGHFCDJJ@IJAGBD:HK>KKEFHGJKGI5KIEJJJHJCJJ?HK3JKK>JFK8IKEKGJKJIJJJJDKKICF@KGKJ?HEEKD8KBFFK@DC3>CDDI1I@FHD:5H>DH&HBDHFGEG?@HE5GBDFH<5B@:DGGG3FFDHFD4EK??@DIHGFEF=4A>>BAG>?D@@@-<87/5.9;9<@<<7AHA>D-;+697<=A:<5:6>7=68<8859>17C@B8B?%>=@A:B9>EGAHB=A7?5A0.9H;E3@D>CA=%<>?BF@>FHIE4EAGJCJA=8<>@7C=4==FBA46AD8ECCFB6;ADC8D:A0@A:=DGEDC@6?=68?A=68>EFB.=@D@E=/HFD8GHAKI@DKHDEDFCH6@CHCFHJ>?;DFG@B@@H9DIFIBDH?7CAJH?DGF=(BF9DEHK:DIFA>HF:F>*=C??FJGIICDH@H@<0CD=2>HKEIG3=BI=DKF3GHKBJGIK=IIGID?C@FHDFG+H@JD@JJ)FH??4E4G?FICJID:?EKK/DG9AGGFH;IHC?HI9FH:>IC?;CJIHGH/H=GKD7GD7AG@IHECD>HKAJGDBJCE61-?8IFCHDGGCE.9>EAF??A>BG/EF;IC-=6FE@;4E@F-JHC6E2@I?B;>=>@GB9HF:E@BD+H8=FFDD&5;I@HII9D9HGFD81@D,@?,D@II;?DECD3@CGGGDD3EAA8EHCD6B?EAD/:G6CF5C;AAFA:?1B5C>IG>@DD7;E=AFH@7@GEBAGG@5>G:?II9A?BH@FB>AEE6@FH@?G<1C=B?'A2F6-DA>C;C4-D@E7I=D>DA;EGC3D94BFB>>;C857<>B:'7.@H@DDA0ED9CIFB=B4EF;10%FDDD:&8BFA;AA3<-@C6FHGI6:DBC>?AFFBDCDI6A50>?FB?@(3>:;3A5CDBACB>=.:A.FH;:9EG?C=BCEADE1F@B:EGB3@G>FCB==?,?A)D:DDHDBDHE>:;F>EC6DA?BD+BD9FEB7D6CC5>795@BBAAG5F;A=AED6DIG8AB7?DBA?@AD:FC@B3%BG<BEE.?6D4A>A23CBA/BHDEE=@3F>CE3ADHICDCD8FE=DEFD5D=DF?EE?IB@EDF4@DB?DF1?97=B9>@>?=EDCCCEGCCBFEAE=F8C9DHD@BE9B=G>3C<;9E=DFB97>CFF*EGF8BC8:87GDH<>?0723D8ED@<.=:4>3C7>3AAB-=?;=6>@*;&:632+D@8=AB;@D9==7?CDC=:@C7=?8DGABABA@?A'&AA4?B:B2::D5:60@;&;CCDB&>9;80><,<;??;A(CD>C:DDB8>54><$;@BC?BBB@:9>'98FF0CCG;<892B-;C: @rCer/1132/1857_64_CCS CCGCCTCCAGCGCCGCGGGATGTAGCGCGGGGGACCGCGGCCCCCAGCAGAGCCCGCCCGCCCGCCCGGCTGCTGAAGAAGAGCAAACATGTCCAGTGCCCCAGGAAGAAGAGGAGGAGGTGCGGGTACTGACACTTCCCCTGCAAGCCCACCACGCCATGGAGAAGATGGAGGAGTTTGTGTACAAGGTCTGGGAGGGACGTTGGAGGGTCATCCCATATGATGTGCTCCTGACTGGCTAAAGGACAATGACTATCTGCTACATGGTCACAGACCACCCATGCCCTCCTTTCGAGCTTGCTTCAAGAGCATCTTCCGCATCCATACAGAAACTGGCAACATCTGGACCCATCTGCTTGGTTTCGTGCTGTTTCTCTTTTTGGGAATCTTGACCATGCTCAGACCAAATATGTACTTCATGGCCCCTCTACAGGAGAAGGTGGTTTTTGGGATGTTCTTTTTGGGTGCAGTGCTCTGCCTCAGCTTCTCCTGGCTCTTTCACACCGTCTATTGTCATTCAGAGAAAGTCTCTCGGACTTTTTCCAAACTGGACTATTCAGGGATTGCTCTTCTAATTATGGGGAGCTTTGTCCCCTGGCTCTATTATTCCTTCTACTGCTCCCACAGCCACGGCTCATCTACCTCTCCATCGTCTGTGTCCTGGGCATTTCTGCCATCATTGTGGCGCAGTGGGACCGGTTTGCCACTCCTAAGCACCGGCAGACAAGAGCAGGCGTGTTCCTGGGACTTGGCTTAAGTGGCGTCGTGCCCACCATGCACTTTACTATTGCTGAGGGCTTTGTCAAGGCCACCACAGTGGGCCAGATGGGCTGGTTCTTCCTCATGGCTGTGATGTACATCACTGGAGCTGGCCTTTATGCTGCTCGAATTCCTGAGCGCTTCTTTCCTGGAAAATTTGACATATGGTTCCAGTCTCATCAGATTTTCCATGTCCTGGTGGTGGCAGCAGCCTTTGTCCACTTCTATGGGGTCTCCAACCTTCAGGAATTCCGTTACGGCCTGGAAGGCGGCTGTACTGATGACACCCTTCTCTGAGCCTTCCCACCTGCGGGGTGGAGGAGGAACTTCCCAAGTGCTTTTAAAAATAACTTCTTTGCTGAAGTGAGAGGAAGAGTCTGAGTTGTCTGTTTCCAGAAGAAACCTCTTAGAGAATTCAGTACCAACCAAGCTTCAGCCCAGTTTCACCCCCACTGGGCAATAAACTTTCCATTTCCATTCTCCTAGCTGGGGATGGGGCATGGTGAGACTCAGCCATCCCCCCAGCAGTTACCCTCCTCAGCAAGGCATCTACCGGCCCCTCACAGAGACAGTACTTTGAAACTCATGTTGAGATTTTATCCTCTCCTCCAGCCATTTTGGGAAAATTTTGGACTGGGACTCTTCAGAAATTCTGTCTTTTTTTCTGGAAGAAAATGTCCCTCCCTTACCCCCATCCTTAACTTTGTATCCTGGCTTATAACAGGCCATCCATTTTTGTAGCACACTTTTCAAAAACAATTATATACCCTGGTCCCATCTTTCTAGGGCCTGGATCTGCTTACAGAGCAGGAAGAAGCAAGCCACCAACTTTTACCTAGCCCGGCTAATCATGGAAGTGTGTCCAGGCTTCAAGTAACTTGAGTTTTAATTTTTTTTTTTTTTCTTGGCAGAGTAATGTAAAATTTAAATGGGGAAAGATATTTAATATTTAATACTAAGCTTTAAAAAGAAACCTGCTATCATTGCTATGTATCTTGATGCAAAGACTATGATGTTAATAAAAGAAAGTACAG + 207917858=>==<,<;>8@?>>?=9=A:@@1ABCB<>7@:<4C?;A;?>=71(+&?:3=B>2=A=>B=:9712;59,;>4@:<9,6==6A?:9=;7>5:>2==<;<794>A>26=5<>A?=;>>=9;B4??BA5@?5A><>=?A7=@CC<;=218B.?6=99A<20;675<.769;>B;=4>22=%9CA>9?;;;@:8A=B:@94*:=??;>;99,2;95>9D=CC=DB>84:;(97GGB47D>HC:FHFIDI?C2A=?A8@9?9;>A?;<6>6C=F@8EFFH>@F6ABD-8G>BHCECJ4DDE4AAAHD7A:A=HG:EGEGH@HCF;?<=8HJH.H;?B-5=A23@D@A@GIDIIGDC?FEB:B@B1?H:@F<:C;FGE;AA<>FDI@FFG>GE@C;BB=@6EB=BH5JGFHFDG?GF>BH=@GFIE2=>CE3GG;FFB=CHB6FKCH=IIK=IJC@I>D9FFCKIJCCDBGCC@6DJI?BHBGIHEH>=GEJ1GEKGK3HIBJGJDFEFBHDF?D=H17:8?@D3@BD3358GB4:DE9F@G>D?@F;7B?FI8II:KIIJ3EEDHIDD(HEBEHEFFB2EG>=>JEICBJA<3;HEGJHKI>ID7BBDIJDGF@B@EDC?DF9=@,57&7>D=?BBD5ABAA@@>6>EI>D<9F;E;A5@D9><>CEB=DCBC?6:25D=HICD=5B4:FE=?==;EBFA@@8D@?B@@B5=6FB<HFKFFBK@JIG;H?AC@4B<;DED>9DIBHFBEGGG,HF>C:F8D5IBGHFAC7A9AA9B?BBCBG>H;D>BA7?<80A@D?=5C:5?@:7>-A4=A?47#C;@FEDAH=0IGDH:HJEDC7DGH>EFHGFB6?>EEGCFEGBC?<29B>HIJ=H=55EB6=JBDHJJJ0IKKA8HFFEJJ.FGH@IHHICJEG;HD:;A1?5FKBII@CGJFHHFDCH8<=CKJ:EKI5ECG>=>@@-?93H@FHIIK1FFHCJCIJKGFC?FJ@B:EAAFIJF)EIC0HB?KEG8ECDDD/GEF2GHGGFKKAFHKDG0K@KK;0A5BBJHIGGDH?FKF@HIECJ:GA4>HJ5HDDFF7FIHJFDJEFCA9BC?;DD7DGIIJIJHG>D:HKIHIGDHDDEIED8GGII/B5>HDI+9KJD4>8>%F>GGAIGEIDKIG?I>BHJJCGK;FC4GA:F=II@?DEGIHDKCE7@?FH2>HJ;J=FI>= @rCer/1135/1731_89_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATTAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCCCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCGGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGTGCAGCTTCCGTAGACTTAGTCATTCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCTGCCCCGCAATATCCCAATACCCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTAACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATTACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACAATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTAATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAAACACCCTGTCATCTATAGGCTCCTTCATCTCAACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTTCAAC + %16511541142252-.3((333000/1.426.664333'23.1//(2/--3'+,)00,.+,/.64/331261324-..30.4,//++3/3233,**--0../.%11331).000.+2(.545240,',12010,0)%(0%1.).++&),,)(/-..,-.310'0,15+/14.114,23.3(11250.0&..'0150-$-%+.%2.443(.643035410.-,1.,2/0+-1&/(-1254,2,*-*%&(5.42,21,.+.--*.5330+0111/-.*)$)*--3014222#)+-'-15324232-0420+53-%2./+3(/5113.)1,1103/00-544,23'-%0-20,,0(+20/('%,0./-*.+0*'-&,#)(0/0$-05/0223*0+*)-%')+*&'$(&(-'-(0$,.%*&%%)&(##%)$*(%(#$(050.()'-+201'*32.+(#+*%)%%&+)'++0,&)%((,*'*1+/-+)-*)&'$#*/*&-/)*%)*&&-,-(*&&&$%,'&)%'*).%+**///%*&##-#.+1531)&426160-.-/%.,%024%2/*(33%,*2036536.313.2**1/..2/0-+..**))'+%*.-0/)-/&%%+).,-/,0212,+024*,0/,++#,*-.,-4-5../0/-2-,0*&$'%,((%.*,./,2).11)1/*,)).4/1.0-034%314.,31200+1//0'(1+.+)&024/0)30502324402.,-+%(2*0/5-(5330..400-22-22,4053104*41+34010.-&/0(#20031+0/(-0.*,&2.3,/00/.0(.2*3.23/132,/--).0/+3200020'(+%2/23//,(-264255,*,234'21/13*')-+2/4231(.2//0.--(-,//51.,14,.(0651261450/.*.+(().+++%0,+(+/.1(*,01)--*$"%((/-&*%(#*%....(+*(--..)#.*)010.1%&&-5611642,2(.%00')*/)./30/2,-'4.3.0*+('.22&,+)//../,2-.++12---2(1,/-0-.1,501536+)/.)3-*(+.+013223031-4453/.0*313112%0&1120300$-0/,%.3414542334201253)10,*+.+**,3.303/.34&/3401/45+2/034541/+(#0+/32/.,*500322,3$,2-+/%001'03,2.2131/1)*355320*),*0/+0./4./2314536/34/2231.3212/,+45342/03.,+05/1200%42)250%,00../+(00/03-23(&('.312,+341/)0/-))/-.-1,0*.&'(..0(01-.1.,.'.+/*2-*/20,0.0---/./02.-0.+)&-*%-,.,-*/..1/-1./--,0/0+/,0//+,..'/++-./*,+110.-0-).&).,-./)*-,,,,-1/1,'1,1*0011-2)+,//&))*+/*/-*(**/,).2.-(%)-'%)-%%+-)--,)-/%$,)'+-,0-.+%&-+'.,102-/(/-)(*.-(*0-,-/00,.0/*&'('',()--*,(+-%,-+,.+(,----(,*++('%#()'*'+---(*+,,$)+,*'&*%))(+-+'&*&+*$+,-(-,+*())),.,+-+()(% @rCer/1139/1534_108_CCS ATGGGGAGTGCGCTGAGCCTCCGTATCGCCGCTGCCGCCTGCGCTTAGGCTGCCGCTGCCGCCGCCGCCCGCGCCTAGCCTGCCGCGCACGCCCGGCTGCACGCTTTGCTTGGCCTCGCCATGCCGGTGGACCTCAGCAAGTGTCCGGGCCCTTGAGCCTGCAAGAAGTGGACGAGCAGCCGCAGCACCCGCTGCATGTACCTACGCCGGGGCGGCGTTGGACGAAGCTGGGCAAAGTGCTGACGCCCACTCAGGTTAAGATAGACCCACCAGCATTTCGTGGATGGTCTTGATTCAGGGAGCTCTACACCTGGTCCTGACAGACCGGATGCTCCAGCAGGAAGGGATCCCAATACAGGGAAGGCTCATTTCCTGGTGGTCAACATGAAGGCAATGACATCAGCAGTGGCACAGTCCTCTCCGATTTATGTGGCTCAGGGCCTCCCAAGGCACAGGCCTCCACCGCACGTCTGCTGGTTTACGAGCAGGCCAGGCCGCTAAAGTGTGACGAGCCATCCTCAGCAACCGATCTGGAGACCACCGTGGCAAATTCAAGTGGCGTCCTTCCGTAAAAAGTACGAGCTCGGGGCCGGTGGCCGGCGCGTGTTACAGGCCGAGTGGACGACTATGTGCCCAAACTGTACGAGCAGCTGTCTGGGAAGTAGGGGGTTACTTGGGGATCTGAAGTGTCCTGGAGCCCCAAGCCCTGTTCCCTAGTTCAGTGTTGCATGTATAATAGATTTCTCCTCTTCCTGCCCCCTTGGCACAGACGACACTGGCCAGTCAGATGGTGTTTGAGGGTGGCTTTTCCTGCTGCCTGACCTTCTAATTTTACTCACTCACTCTGATTTATGTTTTGATCAAATTGAACTTCGTTTTGGGGATATGTTGGTACTGTGATGGGGTCATCAAATTGTTTCATCTGAACATAGCAACCCAGAATGTAAAAAGAAAAAATCGGGAGGTGGGGGAGAAAGACCGTTCTACAGTGACAGAGCAAGCGTCAAATAATCTTTAAGGGAGGTTAAAAAAAAAAAAAAGATTGGTTGCCTCTGCCTTTGTGAACCTGAGTCCAGAATGGTACACAATGTGTTTTTATGGTGATGTTGTCACCTAGACAAGCAGAGGCTGGCATTGAGCTGACCCCCAACACGGTACTCTCAGATGCCTCGACAGGCATCAGCATGTCGCTGTGTCCCCTTTAAAGAGCAGTCCTGGAAGAGGCAGGAGGCAGAGTAGCTTTGCTGCCGTTGGGACGTGGCCATGGAGACCAGCAGCAGCGCTCCCTGACAGCTTAGGAGGAATCCTTACATCTTTGTCGTTAAATTGATCGTTCTCATGGGTCAGAAAAGCTGGTCTGGAATCGCTGAATGTTGCATTAATTGTGCTGTTTGCTTATAGTTGAATAAAAATAGAAACCTGAATG + ))--,%)+),-+,-)'$-(*(#&&&%++,(+-,,-((.,---,),,--)-,),(,(,,)"%((+($()'&,,)$&,)')(),.)+'#+,,*+,%((()+-))'+))&,*-+'&)%),+,(,,*)(-(-(,*,),,)')*),'$*,(,-+,+''%(((-,,-,-(-.,(')),))),-)',$'*'+($(+'(+&&,**(#)'%(&*,-(*%'$,-(%(-,+&(&&$#((,--(--+'--)(+(%,)+)))(&+)+(,)-,*$(,('-.,(-,),)#+-&'-*+$+,-)(+)(%)'()-..*$&+(+*((#,)$)))-,----)'$$#&',*,)*-),--,-).,*(#,,,-'+#'((,,-(-#*&#)+,--),+(+)+-*(,-)'),',)-)-.,'+)++*&')-,(+-)*-),---)),,-()+)*#+(,+'#&*-,-,'*(+,+$,%+$*()+-(.,*-+(*&,"%$(+("#)('#--&'(,&(+%,))(&(&-,*&,..-,&))).,1,.-*.-,',,+,+.%,+1111'1-0-.20+2-1,2000/'/0.-*&.+'&,-($-,*)00.,-/'.*314/)./34,/&0#',,.*532*.2,,11.&&&&&%&%0.-(+$++,,1+0+0/,-+'01)0,/0+10),,%-,+-,,+,-&1.-100-,0'0,%)/*/.)(&,-,+%*(+-+*(,+*$##&(&)%'-*'-'2,,/%,%'0-10**'+%/./,0-00.,0.11+/)+)+%*)+&+',1,//%$0,,'-,,-/'02,&*&.0,5/.-)+2,'23,0.0/+4045.-/)111.++(2/2&.4/2/4.&,$31656330*3252/5664/42,51.-/325141-2113*(3$451/.+.432,%102-05/5060613+.-.(+45/1.%00-.214.3)5.+%41-022.#!%.-0.0,35+402003-/130#&0-.23%),31&-*%/42.+)+/11,//3#00*20-*350.+0*/5504&0604000.4211563.6246053/.+//-33//.//120$/42/235/0(,)+454*01(123645/530+02-55515012.)3/3'34542053#,-46240541-%*/4./+*03663/00116/,/5)..5.20$233/.+*.$2.010513'#0*/4116526/0,/0122006531./)44152044625551(66055*201550'..04+64555*551043,/1025/+.*16041.12012036-5.0/0&61532-,,06/.221%330151-,,%14.,5415-11..0&0+-611&42*22,3-3'#,+'16+30//0*(*-*//-000$253/444',+251//11.1**0-01+301561340604+112/*+/1//+401052..,+%0*//212)/-/2014/005.53 @rCer/1144/667_55_CCS CGTGGGTCTGAGCTTGGAGTACGTGTGGTCACCAGGACTGAGTCGCTTGGAACAGCAGAGCCTGCTCCTTGCGCACCACAGGGATTAATCCTGCTTGTGCTGGGAAATGCAACTCAGAAGTGTTCACTTATCTAGTGCAATATGTTCACAGTTTATTAATGCTTTAAACAGCTTCATGTTTTAGAATTTGTGTATTGTCAATACTTAATTGGGGTGGGAGAGACTGAGCTACACTACTGCTAAACTATTTTTAGCATAATATATACTGTTTTTATGAGTTCCCAGGTTTACTAGAAGGTTCTGGCCCATCGATATTCATTTCATTTAACTCTTCCACAGAACCAGTTTGGGTAGTAGGAACTCAGGCTTCTGATCTGCAGTAGAGCCTGCTCACCTCTAATAGCCAGTTTACAGCACTTGCCTTAGCCTGTTTTACAGACTGTCCACTTACCTTATCACTAATTTTGGACTTTTGGGCTGTGAGTGATCCTTTGATACTTCACTAAGGGGAACGTGGGGGCTTTGTGTTTTGTACTTTTCACTCACTATTTCACTTTATTAAGATGACTGTACAGCAATTTGTATATAAAGCTTATGATTAAAACCTATTTT + D@;?A8=BAD@BFD?+B=EBC;=DD@D>@@CA@8@?AEBABDB/C==DB?D@/AC>?>FDCA@D:A?=E8FADD>:=E<>ED7BC>ACCFE4@B;EFCC4=A4D5EFDBE?EB5FEECD1B3=DADDB6A7BC=B0A>B@<&:8DC:<:;><1DC>DD=EC?ACDD->8A>A;B@?A:C:=@6DE8BCAED9>DBDFF?F9=B5DADBFECB=@ACD5E@AD9C/A@?@=>;7;;BA1==B=BC:ADAC4BECE@D>;3?>B6;BDABCBD>/BBACADB@BE3B4:DDB<=>GCC7B=DEA>:2?C8?BB0@GC;E;>BECD9@BD=B;BEA;DCFEA2C@DC>=<@7@<:>?DHHAHG,GD8AHD=I>?FI?CFB?G>HIHBBB@C:A@* @rCer/1145/25_1888_CCS ATGGGGAGCCCGTCCGCCGCCGCCATGGCCACCACGGTGACCTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATTGGCAAGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATCTGGTCACTGGTGGGGAGCTCTTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTTCGGCCTGGCTATCGAGGTGCAGGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGACATCTGGGCATGTGGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCCGAATGGGACACTGTCACTCCTGAAGCCAAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGAATTTCTCAGTGGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGCCCCAGACGAATAGCACCAAAAACAGTGCAGCCGCCACCAGCCCCAAAGGGACGCTTCTCCTGCCGCCCTGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCCGCACCAGCCAGTCTGAGGAGACCCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGAGCTGCGCCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCCGACTGCCCTCGGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCCTGGTGCCTGTGTCTGCAGAAAAACAAGACCAGATGTGATTTGTTTAAAAACAAAACAAAAACAAAAAAACAAGATGACGACGACAACCACAAAAAAATTGACAT + A9:?GECB:HHCBBIFCDH9B;6B@@CE:FGEIDHEJAI@?GHBF;@B@BAEGIHFAAEDBHID6GIBFIFAIHA>=DFJG?G%BGG@3HFCGDBF*DE?CGCIDIF>G7A>CDHHICBB?HCCDABHD@H:A@?;GBDFFIEC<5HHHJEHHIHHDBBGDA.ABDJDB3DBIG>C6D=GFHHIHCDGHGHH9E@BBBGHIHFGE?8EFB=:A4C?=;;8CBDFDAEC>D<;=EEH>79CIDDHBBG@FG?DDDEDHCG>ED>:HFFD<@@B@5GFFAB@54BEHAEDC9BCEH6DE@AFFCGJGHFBFEDB81=?@BGA@E;BG8;>@>BF:C47>>>C?E=>BGAA4AD=ACH?:A5?=7>?5GD2=BJB?A=?CD@>GGFB:-A?>/@5FG6CC8=IEBC9DB@@D5EFHGADJ9@0<66B>B99(==:BDBABGC?=DCDDB?G>EGDG;AG=BH.CAADDF?BA1=DHFBABGGC>BHGDFE94CB2F?2FHEHBFD;CAFADHHGFCFD*CB=???D7IAHBCGCC@HIF/CBADDEACB9@;FGBFI?F2E@FIJCFHGHFABG>C7:A?@IE<*72G=>F@;?DGCEF:D?DDA6A>?8BBC@CA9@;B>@6B?BBD9B5:@=D87>>0@4@BFII?>B;@7B<9@6B@B>D>DEGGAA@4EGGI>3>BBI6D+FEBHEC.EDAB7HE6@BCCBBA3=GIGE@BDCD@7D@B>BA,8BE;?F>HFGDIGIG@I?BA9DHEIEA9B&A5FHG8ID=GJI=D4ECICC/FGCHB>JIFIH>?IIDCGCJG6FF;GIF?ID?ADG>GG?;HGFH?FCFG5C=GFHG=CGCDBAE;=ADC@A:<@=9DDAEEFCC?:9?BAA@98A4;>ABABDC2;980<=FA?A4?5*?9>CEACEA97GAG4BFBA;DB?CEACFF?EEGFDA??<>FAECEBBEEDB@6B<5FB;;:<=99>9685>A4>7>A=:@;?;@B=;F?;<:68>>CEFEB:G?>CCDEBC;>C>>C1D9><@A>5=E?9=:3;>93?>1:A<4@<>?%<>@?:9=??B7B::?99:?@=79B4CBDEED@CCFA@?DEAB:;DCB;C@;>E+ABD=BA8ABFFFCD0E9FCD*AEACEE7E@FED=A8ED>ACGDFFBAC?E@@BBAFFDDCB@<=>=BFF?;GFFC=AFEBC?DFEBEC8ACEC=3EEA>)ADD<=%AECEED=@G?DDADCEFBB?BBEDF@B%;??=<>AE<<=.6=;975<:5<4?;9=<:8.90:<><;>=6<=?33766:=>;<====>7;9665==<=:6;;:3>>>:6429>4=4<6>3<=9<>>=>>=:;:99;;68+>??9=445938:??7>;=:<.=<<<<>4<>6:::9->3;77;;=?5=8:/>;1<:>?;?<5;;852=:3:;4<9<>;=::892=7>:76981:/<:81>959;355>=>=:?9==/:?=7<6:3:99==<29?:2<;?==;72838;528/.;=9??;>9<:<:6);?:=;6<79;08=/78=::=9<::>=?=;7+<9:2=973<>==>=7><:17>879=692=??890>=::>=9=9<39;9<6<:<94,<7=;5775;<=98;><86;9<>=:9>>=><;==33:9;:;667657=85=5>>?<8<;688?:>6;;><:<=4;1;7=2?992/6???8>=:;88=;>>=7?8:?;0790=67>>+8>3<7:8'6:>:9?:??::9>==894=<>::8=<=:<<09>9<+345<0;>8;;;7=>/>=<994<:<:9979;;8?;828;128:<=>;?<8;>:=6?<==8=:89*;:6689<7;,<>79:-<>9?9+64:/<;<6;/;'426<<2>>=9869*:===;5*:8<:<0<<=:4:;==9<396682>?=770455,;;=<8=9;:><8782;28<>9=8124867$9658<=8:8;<8=3:?<7=<9:9<68?;<8?:4===?521<:<<=>;<<9??9<>96689=<:=?=2;9<>:;=:8==3===<=::7578<;9/:46:56779;$14.;>><>=7;6:;36=:7<89:9<9782;912=)89438?2;=:80<6>?;9>>;=5><56=8:398;>:>:?<=-9?2;;=247041:=73696::7.<89:6:=9<:.699:2<>=9=9>/56<<59=:39:;:492;8=5>67=6:5:<942;46;931)6<3:;>=844:/6:=9=:=/:<==2<<;?=3<567;5989=98:5496>0:;:>=:=85*=>?<:6:;>==6:1.38325/:99:788:8;69667187.5:5;7887/2/3.0/+3682/69566:91797-587885.3643666-747.5827995:5898285-6999:74:1::938495657&497;8968:65::85848;14926;78365569:32::5:975/77(88289:53:645168689-8885:8544574+28%995313+7:32644*948752/293667+6:924-0//'(1+..114545758998:95723163772996+5)8536.4/649/9778239;35775::3:63378-32675(03-../2526:699709172$80:758657;82897855;967296945487::4;;3:78682253292:773829189796559:8.4+863123686958::29;690653733326:28::7295:;886958:7886:847:236963/9;28:593938501):9:8:9:94656/:;49:771(54:689-::85:89-97::859995;73837)79:8835+9:1804998:79;9:;::9.8277.83588/50315/)1;6231'636;7928:8,35983;94::;73574+90989;.973;8668::78-621658718397:99/6566674123:677548786987:5-46/12518;784151677,822;99/12..1232322-5343-/587041588:65-99::7.8:4257/9666176,*528.51::::9:778:5;9847352340%-:78:4617475;9889;:;68-2765&6575:2;5689:446-395939992)5.30782466%0679672492879/5119557.589403485696-604535-822887827009:379:96877731)33868:3;9855154885-953,596378543*.9175678,54;6:8896.87:477+3:840942.248:;:99.8556318594878821466/87:9:7/86955/478-756275.7/5:2358:*;4>475===:==/6;;;95=3<89?88;;9;;38>9>7=>873:<;:07:;78<(::,=<=;;9::.:;;<<-;86877735;9====;=?8=>:7;,30::879;2=?6?<;;(3028=54=;::8)=>;0>>6386;???=?::??;==?;=>9=63<58<149*:9/0:;>;=976<7=:;8'75:======:4;<=<7==;<:>.?>7;07<866:-,49:=75;;<;><=29=>;4=;=;8?:>;;;0=535;.=>6<=><861 @rCer/1147/0_1167_CCS AAGGAATCCTAACACCAACAATCCAAGATATAATCACTTGGGGGCAAAGTCGCTGAACACAATTGCTCTTTCCGTGCTCCTCTATGGCATGTATCATAAAAGCAGCAGAGTTTGCCCAAACCTGAAGATAGCAAACATGGAATGAGTGCAAAATTAAAAGAGATACCTATATAAAGATATAAGAGTCCAAACAGGCGAAACAAAAGAGAATGCCACATAAGATGAAGCACCACCGCGGCGTAGCGTTGTTATAGACGCCAACATCGAACATGGAGTTCGTCAAAACGTCCAACGCTCGTAAGAACGCGAGTTCGAGGTCACAACAATCGGACCACCATGTAAAGAAATGGGCCAGGGCGGCGATGAAAAGAATTCGGAGCGAGAGGGCTCAGAACTGGGGAAGCTTCTAACGCATCCTCAGGAGGGGGCCCCCACCATAATACCAGAAGGCCTGTGTATAAAAGAAGCACCAGCACATTAAAGAAGGAGGCATTCATATCAATTTAACCGCCACAACACCATCTGAAAATCATAAATATTATAAAAAAGCGTTTACGTAAAGACTGCCGAATACAACAGTACCCTAAAGTGGTAATTTAACGAACGGAGATAGAAATAGCCATTTCTTCCTGTTGGTTCATATGGTATGGAAAGGAAGTAAAAGCCCTAGCAGGCTATATCGACACCATCTTAAGCTTTCAACTCGTTTAACAAAGTAGACAAAAAAGATTGTGACCGTCTTTTTGCCAAAAATCCTATCAAAATAGCGCAATCATGCGTCCGGAGAGCCTCTAATGCGTATCCATGAGCACCGAGAACTCATCGGGAAAACCTCGACACTGACTGCCGCATCCTGCGGTGTGGACCAACTTACGAAATGCTCGCCGTGTGGCGCACCGATAACGTTAAACATGGTTAGCGAAAGTTCTATGAACTCCTAGTAAAGACAGACCAATAGCGAGACACTTAGGATAAGCTATAGAGCTACTTAATGGTGCATACGTAAGCCACTCTACGGTCCCTAAATGCCTGTATGACTAAGAAAGTGTAGAGTTAACACTTCAGATACCAAAGGATCAAACCTGCAACATAACCATGCCCCATACCGACACAGCAATCCCACAGAGGATGCTATAACAGAGCTAGAAGCACTTATAAAGCGTGAAG 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@rCer/1148/25_2724_CCS ATGGGGAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGTGAGCAGCACTACGGCCTCCTCTCCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCCGCCTGCTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCTGCCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTGCGCTGCAAGACCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGGAATTTCGATGGCTCTAGTACTTTACAGTCTGAAGGTTCCAACAGTGACATGTATCTCGTGCCTGCTGCCATGTTTCGGACCCTTCCGTAAGGACCCGAACAAGCTGGTGTTGTGTGAAGTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATAATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAATATACCCTCATGGGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCGGGGCCCAGGGACCATATTACTGTGGTGTGGGAGCAGACAGAGCTATGGCAGGACATCGTGGAGGCCCATTACCGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCTGCCCAGTGGGAATTTCAAATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGTGGCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCTAACCCATTCCTGGAACTGGAATGTGCAGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGCACCAGTACCACATCCGCGCCTATGATCCAAGGGAGCCTGGACAATGCCCGACGCCTAACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGCGCCAGCATACGCATTCCCGGACTGTTGGCCAGGAGAAGAAGGTTACTTTGAAGACCGTCGCCCTCTGCCAACTGTGACCCTTTTCGGTGACAGAAGCCTCATCCGCACGTGTCTTCTCAATGAAACCGGCGATGAGCCTTCCAGTACAAAAACTAAGTGACTAGACTTCTAGCTGTCAAGCCCCTCCTAGTTCTTCATCCCACTGCAACTCTTCCCCTCTCCCAGTTGTCCCAATTGTAACTCAAAGGGTGGAATATTAAGGTCGTTTTTCTCATTCCTTGTGCCCAGTTAATCTTGCTTTCTTTGTTGGCTGGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACCTACCCTCCTTTTTTTCCCTATCACTGAAGCTTTTTAGTGCATTAGTGGGAAGAGGTGGGGAACATAACCACTGCTTCCATTTAATGGGGTGCACCTGTCCAATAGGCATAGCTATCCGGACAGAACACGTTTGCAGGAGGGGACTTTTCTTCGAGGTAGCTGAAAGGGGAAGACCTGACTTCCTCTGGTTAGGTTAGGACTTGCCTTGTGGTGGAAACTTTTCTTAAGAAGTTATAACCAACTTTCTATTAAAAGTGGAATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTTGTCTCTTGCTTGTGGACTAGCCTGGCTTGGACTAAATGCCCTGCTCTGAACACGAAGTCAGCATAAACTGATGATATCCCTACCTTGAAAGAAGAAAAGGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTATATTTAATGTAAAGACAAAAAATTATATGTATGGTTTTGTGGATTATGTGTGTTTTGCTAAAGGAAAAAACCATCCAGGTCACGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGAGTGAGGGAGGTGTGCTTAGAAGATGGTGCTCTGGGTTAGTCCTCATGACCACTTCTGGGTTTCTGCCCTGCCACCCTCTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTAGCAGTCACTTGATCTCTGTGGCTTTGGTTTAAAAGACAGACACTTGTCCACATGGGTTTAGAGATAAGAGTTGGCTGGTCAACTTGAGCATGTTACTGACAGAGGGGTATTGGGTTATTTTCTGGTAGGAACAGCATGTCACTAAAGCAGGCCTTTTGATATTAAATTTTTTAAAAAGCAAAATTATAGAAGTTTAGATTTTAATCAAATTTATAGGTTTCTAGGTAATTTTTACAGAATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGACAGGCTGGAGTCAAAACACTTGTAATTTTGTATCTGATGTCTTTGTTAAGACTGCTGAGGAATTATTTTTTTCTTTTATAATAAGAAATAAACCCACTTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCAGCTATGGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAAGTCAAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCCAAAGGAGCACTTATAATCAACCT 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6=)>9'%68:34/17:0<198634897:>>5:9;88157/632.79579:2=-;76>5863=;9;98?8=3::9-<>:5;*4/525(3):95&457'=;8497:9:86:86->8564858-:3:6;:394;><6;7*7:>9>92:47<-:98;:<2>>;)96*55:26)9231*3;=<87<=>=)<330>9689?8637847;863==2>/;;89<<730;95==<9:>98>>79:4;;=%56<7:77:>96:<9;;3171+<,88;/<=>>53<;7'064=<683.88>7<,283>174;>:9956)<393>>;<6?;;=<;0:841<:.;:;;>:89;021;:<>99=716#*56',$+298/983585/796:4?=77<:9>>7>4<>?;?2;91::=1>8;?;>7+758,11/2400=:)3:5058;=;80;5>>:?198<;;>93:694:8?)57;=%9+:>>8?;?<2>==:<:?9?;8>99:3=6499<3-?(;<115,=:>>8=+6937==>>>4'6)8/&/6/>:;::8&3456096:<)5:845;=<7??03/;*;292:6===>1=298&;)991)668,9)"$3782:=9(547;;9;?>:544:/7<;%50%7;:>;-;=9;7<6=0?>9?3:36:8=>:;4?0=4794:/:>:';:=8786<18:9;:5(654.28<>?9/3@7;0;=?;,9<>8';/>>CBCB6>?C>?C?5=B7/::>.B3@?A?A';:;9=<;?B>0?;AB>>?0>@>=B8C9B@8A978;?C>8@CB@B@?;'6:-9464;,=8(:=5?8=A8?8;?===.=:>&878'78<5CB>??>87B@@@:B.9::>.5&638?6C@B<;=A/;?<>.@@>A@9=B?A?9>CC>>?@77<>8@@:6C;?=>8=:797BB8ABB?6<=C*<:&392=.>?3@7B:4>;=>B6@=;.?8>6:>A941;>7<9<.@@??=C@BB/;@-9@<6/4=B@A4=2>($<061A%836?B78=245@@A9?AA>,>:3<%55>?>@?;(>:?/A@?;@?.@@@=<;;C69%;B>9?;<>?A>@<6C@;A(*"2668;:$889:18<;'<:@@4<@CCCA@@>AC(@;97@;89<353>@CB<=+=>=>?AB@7;8>??;8@&=;==9BA>@.;C;:;C>BAA>;/&.,0<*882??<=::A-@63:AB63:;8<93?>A?5:AC?;CBCA<:9@@?.>?=@>=09@8>BA27(>>*.6,'87-+<.%>19=>@9C95@>07;9=<,48>CB+<=;5+;:47;@==C@CB<.70=:@BB;>7.60A?E57BDG>98EC=;@;)A=@C86?A9C+E@<+@C?:;C9G33:(->948C*5*<($:;97=0?8??:83%;8?'DBAG>DB>BG0A@A+CC>-@/@C?ED?:;<>?<78=3??5B<&=/0A/:ABBAF>$A>FE@F1C>2FC29%=B>DEEGE:8GFDFC<@B>9BCC@:57+$?DC&-;;ABECF=:%71?='7>C=1'>:>7G':<;?6DAA>GD?EF>CCABG>?E?=*CCDF=@/A>==F=:>@'?EEC>5BFCDBEFB<9B(<<@>@+?>5>C>CC;>A=AGGA6E0@B48(DF:@C%6?7,CE;@@ABB'43:*??AC8?D><512BFEG=EF;:<2B;>+@F@A;@@7)7C4$A<;4AGB9><%>BAEA>C)@=:A@9:>8AFC.=<7EEA>?$:8;B3F<.?D==?:?B1EE;DD@EG@CCC57;3:?;FB8CBDDB>:79A@B71?E+B:GGBGGBD8D>?@9BA3<;=;B>AEA%<20@EAC=77@AC@;@6A4@>DEGF=?G95GFBCBAFA><@79BDEAD>)>847=?:%BB4C;4B@C.E@7?B6=1?=GCGFGFE:B2CE/DFFDA9GFCEFA(AA@:;>A298AB8CEE>D3GA@:EEC*DD+C<@>=(83BG=@A1<>=@6BEDEC?DC:5BABCFF5G1D?,8EB1=#><<6>,BCC=@?DB='ADEBD=;E;?9D8GDGA8+;(8D<;996+A@<0?4B/>:=A>@43(:<>0<;%;<9>BA$':?>;>=>E>@@+??98@8$@@5$(B?@6A%20<8:BAEA<93:>-;=?DGGC=,@3B36<58@?B-CACD=>FB?,622?EBC@56(?;:@A:>FA?AB@?@8=G?4DBDBB2G0@D;?B6;BDBFC>C@FB24FB=G>B6@49C>>'B;30= @rCer/1149/1572_53_CCS ATGGGGAGAACCACGAGGTACTGCCAGGGTTTCCGCAGTGCCTGCGCCCTCTTGGGTGTTACAGGCCCTCCAGAGTGACGCCCGGCGCAGGAGGCCGCGCCCGCACCCCACGACCTCTTCCAGGGGGGCCTGGAGCAGCCCTCCGCCCCACCGAGGGCCAGCTGTGGTTCCCGCCGCGCGTCCTGCGGACACACTCCTGCCCTTTGCCGAACGCACCTGCACTCGCGGAGCGCAGGGTGCTCTTAGGGCGGCCCAGAACCGCTTTTCTTCTGGGAACCACGCGGCGGGACGCGGGTTTCGGATTCCCTGGGGGCAGCCTTGCTGTGAGTGGACAAGCGCGGAGGCCGAGCTTCTTGCAAACGGACTCCGGTGTCCGAGAGGCAACGACCTTTGTGCCTCACCAAAGTGACCGCTTGGGTGCCGGACGAGCCCTGCCCCTGGAACCCACGGGCGGCCACTGCGCAGGCGCCTCTCCCGGCTGGCGGCTCCGCCCCGCCCCGACCGGCGGCTCCATGGCGCTGTGCGAGGCCGCGGGCTGCGGGAGCGCCCTGCTCTGGCCTCGCTTGTTGCTCTTCGGGGACTCCATCACCCAGTTTTCCTTCCAGCAGGGTGGATGGGGAGCATCGCTGGCTGACAAGCTGGTCAGAAAATGTGATGTTCTGAATCGTGGATTCTCAGGTTACAATACCAGATGGGCCAAAATTATCCTTCCAAGATTAATCAGGAAAGGAAATAGCTTGGACATCCCAGTAGCAGTTACAATTTTCTTTGGGGCCAATGACAGTGCATTAAAAGATGAGAATCCCAAGCAGCACATTCCCCTGGAGGAGTATGCTGCGAATTTAAAGAGCATGGTGCAGTACCTGAAGTCTGTGGACATCCCTGAGAATCGAGTCATTCTCATCACGCCGACCCCACTTTGTGAAACAGCCTGGGAAAAAGAGTGCATCATACAAGGTTGCAAACTAAATCGCCTGAACTCTGTTGTTGGTGAATATGCCAATGCGTGTTTACAAGTGGCCCAAGACTGTGGGACTGACGTACTTGACCTGTGGACCCTGATGCAGGACAGCCAGGACTTCTCATCTTATTTATCAGATGGACTACATTTGTCTCCAAAGGGGAATGAATTTTTGTTCTCGCATCTCTGGCCTTTGATAGAGAAAAAGGTCTCTTCTCTGCCTTTGTTGCTTCCTTACTGGCGGGATGTAGCAGAAGCAAAACCTGAATTAAGTCTGCTGGGAGATGGAGACCATTAGCCAATCACAGGAGACCCAAGTCTGCTTGTTAATCTACAGAACTCAAAGTTGCCAATACATAGAGGTACCCTTTTTTCCCCAGGCTTAAACCTTTGCCACTGATAATAAAAGTATTAGGATTTTACAGGGAAGTTTTGTACTTAGGTCCATTGTGTTTTGACAGTATTTGTTAATGCAGGTATCAGTGCTATAGCTACAAAATATACCCTGAGCAGCTTGTTAATTCTATAAATGATGAAGTAAAGACTTTTTTTTTAAAG + KKKKK7KKKKKKKKKJKKJKKKKKKHKKEKK>KHKKKKKKKIKKKKKKKKKKBKKKKKKBIKKKKKKKKKKKKKKKKKKKKKGK?KKKKKKKKKKKKKKKKKKKKKKK-KKKKKIKKKJKKKKKKKK'KKKKKKKKKKKKHKKKKKKKBKKKKKKKFKKKKKKKKKKKKKKHKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKJKKKKKKK+KKKKKKKKKIKKKKKKKKKKKKHKKKKKKKKKKKKJKJKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKJKKKKKKKJKKKKKJKKKKKKKKKKKKJKKKKKKKKKKKKKJKKKK5KKKKKKKAKKJKKKKKKKKKKKJIKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKGKKKKKKKKKKKKIKKKKKKKKKKKKKKKIKHKKKKKKKKKKKDKKKKKKKKKKKKKKKKJKKKKKKKK@KKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKK2KKKJKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKDKKK6KKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKJKKKKKCKKKKKKKKJKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKK>KKKKKKKKKKKIKKJKKKKKKKKKFKKKKJJKKKKKKKK1KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKBKKKKK6KKKKKKKKKKKKKKKJKKKKKKKKKKKKKJKKKKKKKKKKKHKKFKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKK:KKKKKFKKKKJKKKKKKKKKKKKKKJKKKKKKKKKKKKGKKKKKKKKKKKIKKK8KKCKKKKKKKKKJKKKKKKKKKKKKKIKKK1KKKKKKKK1FK2KKKJKFKKKK4KKKKKKKKHKKKJKIKKKKKKCKJKKKKKKJKKKKKKKKKKKKKKKKK+KJJKKK5K,BKKKKK(BEGKKK,IKKK1KKK1KKKIKJKKKKKGKKKFKKKKKKJKKKKKKKKKK$KKKKKKKKKK>KKKKKKKKKKKKKKKKEKKKKKKKAKKJKKKIKKKKKKKKKKKKKJKKKKKKKKKKKJKKKKKKK>KKKKKKK%JKKKKKKKKKKAKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKK*KJKKKJKKKKKKKKBKKKKKIKKKJKKKKH*AKKKKK'KKKKKKKKKKKJKKKKKKKKKKK?KKKKKKKKKKKKK=KKKK%KKKKKK @rCer/1156/25_2077_CCS ATGGAGAGGCAACGCGAGATGGCGGCAGCGGGTAGCGGCAGCGGCAGCTACCTCAGGAGCTGGTCGCTGTCGGCTAAGCAAGATTGGGGCTAGTCGTCGTCCACCTCCAGCTCGCGTAAGGGTGGCTGTGCGACTGCGGCCATTTGTGGATGGAACAGCTGGAGCAAGCGATCCCCCCTGTGTGCGGGGCATGGACAGCTGCTCTCTAGAGATTGCTAACTGGAGGAACCACCAGGAGACTCTCAAATACCAGTTTGATGCCTTCTATGGGGAGAGGAGTACTCAGCAGGACATCTATGCAGTTCAGTGCAGCCCATCCTAAGGCACTTGCTGGAAGGGCAGAATGCTAGCGTGCTTGCCTATGGACCCACAGGAGCTGGGAAGACGCACACAATGCTGGGCAGTCCAGAGCAACCTGGGGTGATCCGCCGGGCTCTCATGGACCTCCTGCAGCTCAACAAGGGAGGAGGCGCCGAGGGCCGCCATGGGCCCTTTCTGTCACTATGTCCTACCTAGAGATCTACCAGGAGAAGGTATTAGAGCCTACTGGACGCTACATCAGAGACCTGGTGATCCGAGAAGACTGCCGGGGGAACATCCTGATTCCGGGTCTCACCCAGAAGCCCATCACTAGCTTTGCTGATTTGAGCGGCACTTCCTGCCAGCCAGTCGAAATCGACTGTAGGAGCCACCCGGCTCAACCAGCGCTCCTCCCGCAGTCATGCTGTGCTCCTGGTCAAGGTGGACCAGCGGGAACGTTTGGCCCCATTTCGCAGCGAGAGGGAAAACTCTACCTGATTGACTTGGCTGGGTCAGAGGACAACCGGCGCACAGGCAACAAGGGACTTCGGCTAAAAGAGAGTGGTGCCATCAACGCCTCCCTGTTTGTCCTGGGCAAGGTGGTAGATGCGCTGAATCAGGGCCTCCCTCGTGTACCTTATCGGGACAGCAAGCTCACTCGCCTATTGCAGGACTCTCTGGGTGGCTCAGCCACAGCATCCTTATGCCAACATTGCCCCTGAGAGACATTTCTACCTAGACACAGTCTCTGCACTCAACTTTGCTGCAGAACGAAGGAGGTGATCAACCGGCCTTTTACCAATGAGAGCCTGCAGCCTCATGTCTTGGGACCTGTTAAGCTGTCTCAGAAAGAATTGCTTGGTCCACCAGAGGCAAAGAAAGCTCGAGGCCTGAGGAAGAGGAGATTGGGAGTGCTGAGCCCATGGCAGCTTCAGCCTCTGCCTCCCAGAAACTCAGCCCCCTGCAGAAGCTAAGCAGCATGGACCCGGCCATGCTGGAGCGCCTCCTGAGCTTGGACCGTCTGCTGGCCTACCAGGGGAGCCAGGGAGCCCCTCTGTTGAGTACCCCAAAGCGAGAGCGGATGGTGCTCATGAAGACCGTGGAAGAGAAAGACCTGGAGATTGAGAGGCTTAAGATGAAACAAAAAGAACTGGAGGCCAAGGTGTTGGCCCAGAAGGCTGAAGACTCAAAGGAAAAGGAAAACCATTGTCCCACGATACTCCCGGCCCCTTTTGCATCGCACAGTCACAGTGCAAAAGCCCCTGAAAAGGCTGTGGTGATGCCCCTACAGCTAATTCAGGAGCAGGCAGCATCCCCAAATGCCGAGATCCATATCCTGAAGAATAAAGGCCGGAAGAGAAAGGTGGAGTCCCTGGATGCCCCAGAGCCTGAGGAGAAGGGCTGAGGACTGCTGGGAGCTACAGATCAGCCCGGAGCTACTGGCTCATGGGCGCAAAAATATTGGATCTGCTGAACGAAGGCTCAGCACGGGATCTCGCAGTCTTCAGCGTATTGGCCCGAAGAAGGCTCAGCTAATCGTGGGATGGCGGGAGCTTCACGGCCCTTCAGCCAGGTGGAGGACCTGGAACGCGTGGAGGGCATAACGGGAAACAGATGGAGTCCTTCCTGAAGGCAAACATCCTGGGTCTCGCCGCCGGCCAGCGCTGTGGCCCCTCCTGACCGTCGTCTCTTCACTCCGCCTTTTTAAATCCTTGTATAACCCCGTGTTGTGTAAATACAGTTTTTTCTCTG 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((#*1//02,(305266225&,.%-14,3#)%%./1.3526620102-1/(,./1+114,1262.265621*,44+0)3-14,06*451/2+-055500/213335059:34591631:623:76-7537-6254'-/5'..(.475444137*,11+52879/837$+-,2%11235034-44479290+40637-5937./3523,24760847/)1-2245.5+1/22/624:.6/29994,+1220088*71/55:6:466241&10/-/261.1895%-',*35;261670:0358%/6622'296+*496:56-*025030.3:.92.21.37.50'4---//785:54.9,-49:9-8209372-69:396(/55;::::643295;4743&0/0*539:00),0&4.2.462:/720#/.$&,0/'0/332,+23.93(/567262/2&3500.466*.(%.&'((&2/-422%+,/4&07306398202-+-6-191+1+3-07355562,205&9.87:545-.+5,*271$*22,,7-2/291'/25*./%-/1.445:'314*4200061588324*''58422+,)(167*20:25711,0,*732.24025:14.661*20&..012.1&/3058/'0306/-/222(864/284734(.115$35634.*552)((#+..,$.2+'+0'*-.82/+5+*)*+/1.410753.2--30*5,,-+(($00,3,-3.23/41+9,0.23/5/577502//,&07253375;:+20.2-3.2-4483.000915654575:31-24-448.:9413876464%,12,2/4128-15092:45*0//94524.4034,754114630882::52175-6584,-299;+6415/1431.56018(2069.7645,4864451-134:-723.),/+45/5/6-082651586.52134:94:9377535.640/0.-846%0184-1)/+0&&'#1-+)02455915583+53-1,/2,4/+1-.+,37,555,+17:1174-(6.024-432824&475:.6%7-:8+:53+&)15/4-1*.$'(&**-%-0-42(-,300)/.460/602+/*5(233343414//10'.493131(1.587/469+/&(-223-8654/5/)32.*,+057+,.),$,..+,304'.090120,)1-(-64715:515/:9.:9*.2&46)./75696084,7-*.(4103011+.155-%2.0+,54/.9293.4+4(/3*2/361:15445664933,31,443.,2/2+/5.23)-17:2&/06'/'44'78662,5424.0,,1468981.4.,&+2)488289871#*43334..2.,2-0.15/706213.,-85696/4::419:536242%)/73936128-554./.:833599/66752,7+(--.79-613,2&115754/4./04..285404(6-.6159/+0'445.45336--64,895('74'2004-694.8850658;;27:8>8343-70*6%/**4-:><88%676)56781-45:<>328.6/373470031437/229:93966;>7-'30-#,*-.//42:89)1243839=7359,-73:71;+8-1+656:8>>7<1.1-)3)77624.,2,8:6851=7>2365:9,.1&+''30./4(13,1.)./13524/-').7422:/6:9031993)/05)/*,/493%#-010/4++,010471/,5)350,-04947697-3143.*0&$.(,31&)%1+9-84-32*2+/++'*%*50+6))7+1.442244'74,/07.4854.4.233+..$)-'.+585;0%/)+(/.51754,601-95+,$*1,21.+.*36&45-2214:54++).01).33390-/1,1(+$0-2070*12/54/..-63:08*157,.7)5403)5.5+*305143366,2222485.975:526)5124.46523,82025,0-600-(+&,/03-%0445+-4/3:634'/44: @rCer/1157/1696_55_CCS ATGGGGCGCTCCGGCCGCTCCCGCGGCCCGTGGATGGGGGTGTCCGGCTGAGCCCCGGGATCCGCCTCCCTCCGCCAGGACCCGCACAGATAAACTCATCCTGAAAGTCGCTGTTGTTCTCCTACTGAGCAAGAATGGAGGCCCCACTGGTGAGTCTGGATGAAGAGTTTGAGGACCTTCGACCCTGCTGCTCGGAGGACCCGGAGGAGAAACCCCGGTGTTTCTATGGTTCATCTCCCCACCATCTCGAGGACCCCTCCCTCTCTGAGCTTGAGAATTTTTCTTCCGAAATAATCAGCTTCAAGTCCATGGAGGACCTCGTGAATGAATTTGATGAGAAGCTCAATGTCTGCTTTCGGAACTACAATGCCAAGACCGAGAACCTAGCTCCCGTGAAGAACCAGTTACAGATCCAAGAGGAGGAGGAGACCCTTCAGGACGAGGAGGTCTGGGATGCTCTGACAGACAATTACATCCCTTCACTGTCAGAGACTGGAGGGATCCAAACATCGAGGCTCTGAATGGCAACTGCTCTGACACTGAGATCCATGAGAAAGAAGAGGAAGAGTTCAATGAGAAGAGCGAGAATGATTCTGGTATCAACGAGGAGCCTCTGCTCACAGCAGATCAGGTAATTGAGGAGATTGAGGAGATGATGCAGAACTCCCCAGACCCTGAGGAAGAAGAGGAGGTTCTGGAAGAAGAGGATGGAGGAGAAACCTCCTCCCAGGCAGACTCGGTTCTCCTGCAGGAGATGCAGGCGTTGACACAGACCTTCAACAACAACTGGTCCTATGAAGGGCTGAGGCACATGTCTGGATCTGAGCTGACCGAGCTGCTGGACCAGGTGGAGGGTGCCATCCGCGACTTCTCGGAGGAGCTGGTGCAGCAGCTGGCCCGCCGGGACGAGCTGGAGTTTGAGAAGGAAGTGAAGAACTCCTTATCACGGTGCTTATTGAGGTTCAGACAAGCAGAAGGAGCAGCGAGAACTGATGAAAAAGAGGCGGAAAGAGAAAGGGCTGAGCCTGCAGAGCAGCCGGATAGAGAAGGGAAACCAGATGCCTCTCAAGCGCTTCAGCATGGAAGGCATCTCCAACATTCTGCAGAGTGGCATCCGCCAGACCTTTGGCTCCTCAGGAAGTGACAAACAGTATCTGAACACAGTCATTCCTTACGAGAAGAAAGCCTCCCCTCCGTCAGTGGAAGACCTGCAGATGCTGACAAACATTCTCTTTGCCATGAAGGAGGATAATGAGAAGGTGCCTACTTTGCTAACGGACTACATTTTAAAAGTGCTCTGCCCGACCTAACCTTGCCCTTTGGAGCAGCCTCGCTGCAGGAGGTCACTGAACAAGAGTCATTCCATCACAGGGACTGCATGACACCACGTACCTCCGACGTGTATTTAAACGTGTATAGCTAACCCGGATTAAACATGAGCAAACGCGCGGGTCCTTTGCTGTTGGCTTCTAGTGCTAGTAACCATTGGATGCATGATGGGGCAGGGCCGGTGATGGTGCTCCCTTGCGGTGTCGGGAGAGGGGAAGGCAGCCGCTTTCACTGCTCATTATGTAGTTTGGCTCCAGCCCTCAAAAACAGCTTATACTGTAAGACTAATTTTGAAATAAACCTTCATTTAAT 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ATGGGGGGAGTCCGCGAGCTGGAGCGGGAGCCGCCAAGTCTAGCCGCTGGCGCTGCGGGCCGGGGCCTGAGGAGGCCACAGGACGGGCGTCTTCCCGCGAGAGGAGCCGGCGCGGGCCCGCTGCGGCCGCACGTGTGAGGAGTAGGCCGAGGAGACGCGGTCCCGGCGCCGCGGAGGAAGCGCTCCACCAGGGCCCCGACGGCACTCGTTTAACCACATCCGCGCCTCCGCTGAAACGCTTGCTGGCGCTGTCACCGGTTCCTCCATTTTGAAAGGGAAAAAGGCTCTCCCACCCTTCCCTGCCCTAGGAGCTGGAGTCGGAGGAGCCACGCTCATGGCGTTCAGCCCGTGGCAGATCTGTCTCCCGTGCAGTGGGCGAAATGGACGTGGTCTGCGGTACGCGGCGGGCCGCTGGCGAGGACGAGGCCGCGACCCGAGGGCGACCCGAGGAGGAAGACTCGCAAGCCGAGACCAATCCTTGAGTTTCAGCTCGGATTCTGAAGGTAATTTTGAGACCCCTGAAGCTGAAACCCGATCCAATCACCTTTCAAGGAGTCCTGTGATCCATCACTGGGATTGGCAGGACCTGGGGCCAAAAGCCAAGAATCACAAGAAGCTGATGAAGAGCTTGTAGCAGAAGTGGTTGAAAAATGTTCATCTAAGACTTTGTTCTAAACCTTCAGAAAATGAAGTGCCACAGCAGACCATTGATTCTCACTCAGTCAAGAATTTCAAAGAGGAGCCTGAACATGATTTTAGCAAATTTTCATTGTGAGGCCATTTTCAATAGAAACGAGGGATTCCACGGATATCTCGGCAGCCCTTGGAACAAAAGCAGCTCATGGCTGTGTAACTGCAGTCTCAGGCAAGGCTCTGCCTTCCAGCCCGCCAGACACCCTCCAGGACGAGGCAATGACGGAAGGCAGCATGGGGTCACCCTTGAGCCCTCCACAGAAGCCAATCTAAAAGCTGGCAACTCCTGTCCAGAGCCTGTGCCCAGCAGAAGAAGCAAGCTGAGAAAGCCCAAGCCTGTCCCCCTGAGGAAGAAAGCAGTTGGAGAGAGTTCTCAGACACCGACGCTGCTGCGGAGGTACACCTCTCCCAAAGCATCCTACCACTTCAGTCCTGAAGAGCTGGATGAGAACACAAGTCCTTCTTCGCTTGGAGGTGCCATGTTCCAGAAGTCTCCCCTGACCTTAAAGAAACTCCCGGCACTCTCAGTAGTGACACAAACGACTCAGGGGTTGAGCTGGGGAGGAGTCCAGGAGCTTACCTCTCAAGCTTGAGTTTGATTTCACAGAAGATATGGGAAACATAGAGGCCAGGAAAGCCCTTCCAAGGAAGCTTGGCAGGAAACTGGGTAGCAAACTGATTTCCCAAGATGCAAAAAGATGCATCAGTAAGTCAGCAGTTTAGAACAGCCTACAGACCCAGTGCACGTGACGGCCTCTTCCCAAACATCTTCCAAGCTAGATCTAGTCAGTGGGAAAACGCCAGCTTCAACCCCTTTGGGAGCCACTCTATTCTGCAGAACTCCCATCCCTTTCTTCTGAGGGTTCTACCACTTTGACCAGATAACTTTGACGAATCTGTGGATCCCTTATAAACCAAATACGACCTTAAACAAGCAGTGACTTTTGTTCTCCCACTGGTAATCATGTTAATGAAATCTTAGAATCACCCAAGAAGGCAAAGTCGCGTTTAATAACGACTACTGAACAAGTGAAATTTCTCTGTTTTCTGTTGAGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCTTTGGATGCATGTTCCCAGGATGAAGGAGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCATGCTACCGATGAGGAGAAACTGGCATCCACGTCATGTGGTCAGAAATCAGCTGGGCCGAGGTGAAAGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCTTGGCTGCTGGAGTCCTCTGCAGAGAAGGCTGTTGTGTCAGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATCAGACAAGACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATCACTAAAGAGATTGAAGCAAATGAATGGAAGAGAAATATGAAGAGACCCGGCAAGAAGTTTTGGAGATGAGGAAAATTGTAGCTGAATATGAAAAGACTATTGCTCAAATGATTGAAGATGAACAAAGACAAGTATGACCTCTCAGAAAAGCTTCCAGCAACTGACCATGGAGAAGGAACAGGCCCTGGCCGACCTAACTCTGTGGAAAGGTCCTTTCTGATCTCTTCAGGAGATACGAGAACCTGAAAGGTGTTCTGGAGGGTTCAAGAAGAATGAAGAAGCCTTGAAGAAATGTGCTCAGGATTACTTAGCCAGAGTTAAACAAGAGGAGCAGCGATACCAGGCCCTGAAAATCCACGCAGAAGAAAAACTGGACAAAGCCAATGAGGAGATTGCGCAGGTTCGAACAAAAGCAAAGGCTGAGAGTGCAGCTCTCCATGCTGGACTCCGGAAAGAGCAGATGAAGGTGGAGTCCCTGGAAAGGGCCCTACAGCAGAAGAACCAAGAAATTGAAGAACTGACAAAAATCTGTGATGAGCTGATTGCAAAGCTGGGAAAGGCTGACTGAGACTCCCCTGTTAGCTCAACAGATCTGCATTTGGCTGCTTCTCTTGTGACCACAATTATCTTGCCTTATCCAGGAATAATCGCCCCTTTGC 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40(3../4214/255..1$0*4002*,//.06/)531(25500)/-+1)0+**/.,#-,/3'42/+4345.6/'3)223-%15-)5531--36*.$$//,03)30/*4)+541(04266-(.),$./3011$/12105323514)50/14565)'(-3/1,%0203)142)/'0004/01+005/50*54*2.(1/5.-0-21/2500066-2--.++,)1-),(/4/6(,.$%%/..315.4-*.-2'2/-**%.2615'/./10*0-25*55/62.42.6531//-(652(02(1()*,0-43/112025110-320/25.0*-2651*2/153-403*4/3'&33,0)25332.$,'/(0+3242(/565+1302252113+.2-/645.21..$,241/51,,+*.,5406221(-.530,414$+$/'0./,'.40-0'4531-65243654540/5145)335//2.$01*346500*1/.10.0)&*()1))-(2&-204)*&)(-.2-/*4/',/.4.4*5/.+0,-+-,123*/$-(-.354&/+12&4/+102446223250&,/123*422242)4.&134/1%2103/.*33260014063/33254,0114240-,51440+10(,./**+11*22243.+0.-*(0.,-10&344,413&222223041+5663/-//-313&.,/),.,+.6632**6'67/+315374091(6.683+:906497933655770/25)16224.+58&-)"$-680.+1*7(5/+3843495-.'68301/597(4415905/75.-2.+427/-796;6;284-4416526..129276574:7(320858624880494.20939/12).0609+5)-96,6056..*0,*(*0/8584:-6:6;51651789.16-4642'2872/3.8:4515%/845:::694366396961-(/46/45/79287254444-77559&77555*5/-0/.+.:9/5953:856958,606384275/6201&30/.82234.31.992-0105/5/%.+0,%067:89.762134245/45&+0/-'+7'-13+0/31&-1*3271953:54..52*242*027::58444276932*40&--92%368(13964;7::56097384125).-./3;:4.85122%173*460934-241).1+0/5:-:665:67//57470:0(-0+/3--)+3.43;942:8/027'3560,91'2577540/-5:1120206478:46252363672954-5/389('/85*6'%74455557.5+3635)470,86-4-9-93:3742.7-5907;/7879.3849851506986&30%4-236:826)0796028.1+44457001119701/(588:/:66:5880/'-5)751+/.)-,26:7*'2$*23)%%13.9435:4+4/5+1((.2,*'(/,.'**&1,41'3440//33.././'+$*1*&/0#++0,.44.+3.*,1-3.46946/7-7634(41&02&+6-115'0/20(220423&-766,51646(0,+6;92/06777646.:75*6836&*6;8.416:968--,0+7%+/4.35.2,+1.,-4:53&9/136:46657606.433:445::5*6745*4.40-3%++.6%4836&54-49::9575399475'7558:4:5666:8395820696::5,235.8653979;55396;8202/4(366-882::663+%2639571005569761:63658948474:-852(4985/6/7:9:7560,49745:8:86:65/4143.64/45:,6-853556&246943%./15./'143.7978475-116./,-/815;88>:9:0;7074954%4:42572;6:3>7%638382416575493/;2088<;?58<+9267*87>:+2::2;74658;71*%33>=28/:1)/6?58/;930167:245:<;=:>>=>>9484<8:=>4::8?98=35<)<;396+8956?;5619;.>6374;>5<><>6=3:?::=39+58<7/:4.088;;4;)55211*5736<:;91:512<;3:;2/98:>6>9=>9>4;:4;;=<$2.9=:606;<;=46+267;>:76265)47857<=7<<:4<6?>99;/9=68:4:?:396'87344=:>9?>>>:*=34>>8?=0:;:>>2>:1>.%;<9:><9<36)06:::;88:;><>6:8;:/74:955;(98=29:8/:0;1:87/;-<75*759'0.,'12:6>>9:5=%;;1:2$279;79470(2;>?:9%.3879<;886/6-3697;?6>993?>9596$-((<61:8*:6=;:>185*<:2;;?;.73-9<:53:+992-210:9:97.7*853291-3989475;378:1833097)14/69'568?6?;>82?>>9==>:;;0=??>152;=97:>5.>=?7;>:?<:;2:6:883:5>?>=>;><9884637=.;<1826:509;9?4:<692:>7;877>3;;,65/6)2624=9770<94;6:3=9,87693,/4*4:.2442;;5=8:2463113-4$5?=:?><).348=&:0*987?9:==2:31.3:3(:626:>:>349;8=7207:832>97;?165>?>298/5*.,8372:29-2/;6671939?7=885?,9;7<91;3:>%78<6;>4< @rCer/1159/0_2047_CCS CAGCAAGTACCATGGACCATGCCAGCATGGCTTCCTCCCAAGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGCGTGAAGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG 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@rCer/1161/2128_48_CCS ATGGGGGAGGCAGGACGGTTTCTCGAAAGCAGTCGGTAGTTGTAGTTTTGCTAAACCTAGAGCGCTTCAAATAGCAAGCAAGGAGGCCGCGAGGCCTGACGGGATTTGTAGTCGGCGCGAGAGGCGGCGCGCACGCGCAGCCGGGACCGGGGCGGGGCCGCGGCACTGCGGTGAAAGCCGAGGCAGCGGGCAGACGAGCAGGGGCGGGCGGACATCTTGGGATCCGGAGAGTGGCCGGGCCGGCAGAGAAGGGGCCTCGGGACACCAGGTCTGTTCTCAGAGCAATGGGCCGCGGAGACTGATCTGCCGCCATGATTGGAGGCTTATTCATCTATAATCACAAGGGGAGGTGCTCATCTCTCGAGTCTACCGAGATGACATCGGGAGGAACGCAGTGGATGCCTTTCGGGTCAATGTTATCCATGCCCGGCAGCAGGTGCGCAGCCCCGTCACCAACATTGCTCGCACCAGCTTCTTCCACGTTAAGCGGTCCAACATTTGGCTGGCAGCAGTCACCAAGCAGAATGTCAACGCTGCCATGGTCTTCGAATTCCTCTATAAGATGTGTGACGTGATGGCTGCCTACTTGGCAAGATCAGCGAGGAAAACATCAAGAACAATTTTGTACTCATATATGAGCTGCTGGATGAGATTCTAGACTTTGGCTATCCACAGAATTCCGAGACAGGCGCGCTGAAACCTTCATCACGCAGCAGGGCATCAAGAGTCGCATCAGACAAAAGAAGAGCAGTCACAGATCACCAGCCAGGTGACTGGGCAGATTGGCTGGCGGCGAGAGGGTATCAAGTATCGCCGGAATGAGCTCTTCCTGGATGTGCTGGAGAGTGTGAACCTGCTCATGTCCCCACAAGGGCAGGTGCTGAGTGCCCATGTGTCGGGCCGGGTGGTGATGAAGAGCTACCTGAGTGGCATGCCTGAATGCAAGTTTGGGATGAATGACAAGATTGTTATTGAAAAGCAGGGCAAAGGCACAGCTGATGAAACAAGCAAGAGTGGGAAGCAATCAATTGCCATTGATGACTGCACCTTCCACCAGTGTGTACGACTCAGCAGTTTGACTCTGAACGCAGCATCAGCTTTATCCCACCAGATGGAGAGTTTGAGCTTATGAGGTATCGCACAACCAAGGACATCATCCTTCCCTTCCGGGTGATCCCGCTAGTGCGAGAAGTGGGACGCACCAAACTGGAGGTCAAGGTGGTCATCAAGTCCAACTTTAAACCCTCACTCCTGGCTCAGAAGATTGAGGTGAGGATCCCAACCCCACTGAACACAAGTGGGGTGCAGGTGATCTGCATGAAGGGGAGGCCAAGTACAAGGCCAGCGAGAATGCCATCGTGTGGAAGATCAAGCGCATGGCAGGCATGAAGGAATCGCAGATCGCGCAGAGATTGAGCTTCTGCCTACCAACGACAAGAAGAAATGGGCTCGACCCCCCATTTCCATGAACTTTGAGGTGCCATTTGCGCCCTCTGGCCTCAAGGTGCGCTACTTGAAGGTATTTGAACCGAAGCTGAACTACAGCGACCATGATGTCATCAAATGGGTGCGCTACATTGGCCGCAGCGGCATTTATGAAACTCGCTGCTAGCTGCCACTAGGCAGCTAGCCCACCTCCCCACCCACCTCTTCACAGGTCCAGGTGCCGCTCCCTCTCCACCACACATCAGTGTCTCCTCCCTCCTGCTTTGCTGCCTTCCCTTTGCACCAGCCCCTGAGTCTAGGTCTGGGCCAAGCACTTGCAAGTGGGACTGGTGGAGTAGCCCCTGGGCTCCCTGGCAGGGAAGTTCTGAGGCTCCTGCTCTCCCTCCACCTGTCTGTCCTGGCCTAGTGCCAGGCTCTGAGTTCTGTGACCAAGCCAGGTGGGTTCCTTTCCTTCCCACGCCTGTGGCCGCACCTCTGGAGTGGGAGGGTCGGTTGCACCCCTCACCTCAGAGCTCTCCCAAAGGCCAGTAACGGATCCCCAGCCCTCAGTCCCTAGTCTGCTTTGGGATAGTGTGAGCTTCATTTTGTACACGTGTGACTTCGTCCAGTTATAACCCAATAAACTCTGTAGAGT 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@rCer/1163/25_2304_CCS ATGGGGGTGCTCGCCGTCTCCGCCGCATCTCCACCCGCGCCGCCGCCGCAGCTCCCGCGCTCGCGCCACCGCCGCCGCGTCCACCTCAGCGCCACCGCCATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTTTGGGAGGTTATCAGTGACGAACATGGCATCGACCCACAGGCACATACCATGGGGACAGTGACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGGAATTATGTCCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCCGGCCCCTTCGGTCAGATCTTTCGGCCCGACAACTTTGTGTTTGGCCAATCCGGAGCCGGCAACAACTGGGCAAAAGGCACTACACGGAGGCGCGGAGCTGGTGGACGCCGTCCTGGATGTAGTCCGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGAGGTGGCACGGGGTCTGGGATGGGCACGCTGCTCATTAGTAAGATCCGCGAGGAGTTCCCGGACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCGGATACGGTGGTGGAGCCCTACAACGCCACGCTGTCCGTGCACCAGCTGGTGGAGAATACGGATGAGACCTACTGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGACCACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTGCGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCAGTCAACATGGTCCCCCTTCCTCGCTGCACTTCTTCATGCCTGGCTTCGCGCCCCTGACCAGCCGGGGCAGCCAGCAGTACCGGGCCTGACGGTGCCTGAGCTCACCCAGCAGATGTTCGACGCCAAGAACATGATGGCCGCGTGCGACCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTACTTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCTGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGGCTGCAACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGATCTGGTATCTGAGTACCAGCAGTACCAGGATGCCACTGCCGAGGAGGCGAGTTCGAGGAGGAGGCGGAGGAGGAGGTGGCCTAGGCTGCTCCCATCGCTTCCCATCTTTCCCTTGAGGCTTCTGACCTTTGACCCCCTAGGCCCCCATCTCTGACCCCTGGAGCCCCACTTTCCCTCCAAGCCTGACTTCCCTGCAACCGTAAGACTTGGCCCTGACCCTAACAATACCTTTGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCAACCCTGGCTCCCCTTTGACCCTTGAGCCCCAATTTATCTTTGACCCTCTTGAGCTCTTCCAACCTTGACATTCCCAGGAGGAGCCCGCTTCACCCTTCTGACTCTGGGAACGCGCCTTTAACTTTGCGGGTCCTCCTTCACCCCTGACCTCTGCTTCACCTTTGACCCCTGCCCCCCATGAATCCCATTTTACCTCTAGACCTAGAAGTTCTGGTTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCTCTGACCTTGCCTCACCTTTAACCCCATCACCTGAGCCCCAGCTCCTACCTCTGACCTCAACTTCTCTTTGACCTCTGAATCCCCTCTGACCCCAACTTCTCTTTCACCCCCATGAGTCCCATTTTACCTCTACACCTGTAAGTCCTGGTTTGCACTGGACCCCTCCTCTGAGCTGCAGTTCACCTTTGAACTTGCCTCACCTTCCACTCCCCACAGCCCCAGCTCCTACCTCTGACCCTGCTTCTCCTGGCTCCCACAGGCCCCATATGCGTCCTCCCTGCCTCACTCCCTCAGCCCCTGCCGACCTTAGCTTATCTGGGAGAGAAACAAGGCCCGGTTCCTGTGAGGAGGAGAGGTTGCCCCTGCCCTCCCTTCCCGCATCCCTGCCTTGCCCTCAATAAATAAATTGATTGTTGTCC 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@rCer/1167/25_1827_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGAGCTGAAGAGTATACTGCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTAAACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTTGGCTTGACTCAGGAATTTAAAAACTGGAACGGTGAAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCACTAAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTCGTGTAAATTATGTAATGCCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCTT 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@rCer/1168/3086_59_CCS ATGGGGGGGCTTTCCGAGGACCGCGAGCAGCTGTGCCCAGAGCTCTGGGAAAGTCCCTCTTTGCTTCTTTAAATTAAGTTCCTTTCCACCAGTTAGGGCAAGTCAGCCAAGATAGACTGAAGAGGAGCAAGAACAGAAACAGGGCAGTTACAGATCCATCCCAAGAATTCCGAGGAGAGATGATGCTGTCTGCAGCAGAGTGACAGCAGTGGAGATTGAGAGAAAAGGTTGAAAATGGTTGCTTGTGTTCAACTACTGTGAAGAGTTGGAATCAGACAACTACAGCTTTGATTTTCCAAGGGGTTCAGAATGTAAATGTGATCTGACCTTTCCTGAATGGACAGTTAAATCATGGACACGCTAAACAATTTACTTTGGACTGTCCTTCCTAAAGATGCTCTGGCTTCTTTCTTGAATGCCCACTAAGCATTGGTGGCCGACAAGGAAAAGAAGGAAAACGGTGAACTGGAAAGTTACCTTACAATGAAAAATTACGAGCACATCTTGCATCTGTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAGAGGTGGTTATGGAACCGCTCACCACAGCTCCATCAAGGTGACGAGAAACCAAACCAAACACATTGAAGGTGAGACCGAAGTCCACCATCGTCCCAAAAGGGATGGGTATGGAATCAGTTCTTTGTTTTAGAAGAACATATGGGACCAGATCCTCAGTATGTTGGAAAGCTTCACTCCAATTCTGACAAAGGTGATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTATATTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAAAGCCTAGACAGAGAGCAGAAGACCCACTATGTGCTTCACGCTCAAGCCATTGACAGACGTACAAACAAACCTCTTGAACCTGAATCTGAGTTTATCATCAAAGTGCAAGACATCAATGACAATGCTCCAAAATTCACAGATGGACCATACATTGTTACTGTGCCTGAAATGTCAGACATGGGTACTACTCTGTTCTACAGGTGACAGCTACTGATGCAGATGACCCTACCTATGGAAACAGTGCTCGGGTGGTTTACAGCATTCTCCAGGACAACCCTACTTCTCCGTCGATCCTAAAACAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCGGTGGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGCTTTCGGGGTCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCGCGCTTTCCTCAAAAACATTATCAGCTATATGTTCCTGAGTCAGCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCCGATACTGGCTCAAATGCTGACATGACCTACTCCATCATAAATGGTGATGGCATGGGGATATTCTCCAATCTCCACTGACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAGAAAAAGAAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTTCTCACCTGGGTCCTTTTTAAAGATGCTACCATGCTGAAGATCATTGTTGGGGATGTAGATGAACCACCACTCTTTTCCATGCCTTCCTACGTCATGGAAGTCTATGAAAATGCCAAGATCGGGACCGTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTGCTAATAGCTTAGTAAGATACTTCATCAACTACAATGCTGAAGATGACAGATTTTTCAACATTGATGCCAATACTGGAACCATTAAGACTACAAAGGTTCTTGACAGAGAAGAAACTCCATGGTACAACATCACAGTCACTGCTTTCAGAAAATGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGATGTCAACGACAATCCACCCGAACTTGCCAGGGAATATGATATTGTTGTCTGTGAAAATTCTAAGCCTGGCCAGTTTATTCACACCATCAGTGCCACTGATAAAGATGATTTTGCCAATGGACCAAGGTTTAACTTCTTTCTTGATGAACACCTGCCTGTAAATCCAAACTTCACTCTGAAGGACAATGAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTTCAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTCAGCAGCAGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGCGTGCGGACCTGCCATGCGGAAGCGTTTCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTTCTCTGTGTTCTCATTCTCCTGGCAATTGTGGTAATTTTTATCACCCTGAGGCGCAGCAAAAAAGAGCCCTTGATCATTTCAGAGGAGGATGTACGGGAGAACGTGGTCACCTATGATGATGAAGGAGGCGGAGAGGAAGACACGGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCTGCTGCTGAGGAGCTCAAGTACCGGAGAGATATCAGACCTGAAGTGAAGCTCACTCCCAGACACCAGACATTGTCCACCCTGGAAAGTATAGATGTTCAGGAATTTATTAAGCAAAGACTGGCAGAAGCAGACCTAGACCCTAGCGTCCCCCCTTATGACTCTCTTCAGACTTATGCCTATGAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACACAATCAGACCAGGATTATCACTACCTTGGAGACTGGGGACCTGAGTTTAAAAAGTTAGCTGAACTCTATGGAGAAATAGAATCTGAAAGAACAACTTAGGGGTCAGTCTTACAACGTTGTGGAATTTGCTTCCTGAGTAAGTGGAGATACAACCTCAGCAATGACAAGGAAGAAGTGTGGAAACAGTACTTAGAACTGAGCAAGTTGGACACAGCTCCTGTAGAAACAAGTGCCTTTTCATGATCGAAACTGGGTTATTTAATTG 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88:84028,036(0.75/.55.3376/-6625574956:.,44576:967501222&3.5;-7797919496+3/4,275729;4713;57845566411,317856131351.5*14/65756/---93451241,3(35960318;956896:;58460.:13:23)43/9958..65688646.:78924:563//.55/.-1*0/36/:696*842868;:1-,7/7:8./5;68+05:54/(105:79446695895371//6*42:89:.19*80/802737'7649:17863::309031::673/74%0114-./24-3-10)4&3.,%46744123034+24576'579686.8:+8;767*.6240302886063;2/1454-4.(/3/0(1.45+/*(+.7,945:884*82994-86613-6,'1,43,0364588*9/332-54)+*,/30+5::466*6;39817.294330-0+/#.,+48523/00/12055437-9:942202*'-0222/,4.313186*92.6/-&-((-%6-431&6202),27..98:296857::8:)8626845419=0?>9>874:8/:576:678/7963677760=516>77824//2//:'>99172)209=,==27/1,/53+1$055(26;<-;:5,/=14783299(5<:>84882348263,5:+50:81<>=8==98;1<6;8;771:>;8:.:;=2:9388;;>96*75>>4879<(759<1+200/)'*99,4&6%5362<:*0:,=>;>99;6-83/22272244354=925*66;<=:<8.6;18/;4>=9;>;><7796<9<:2>:;04;87:3/63-6::9;658/15-::>254268<835,2<;'6786;61>:?767<719<77266'5;40$333&6526-*,/1132003-0-2..3505-402%36561.18.1305.32,012%)22;783)22*6377151-26-3443$)(3/%%'.6549=7898:20/875;457+-6039.35+562&'(,,3-*$0+051134533/:0*-03)0503/%,/01./4))'2*/5$34/&--*1*03,10.(/+27766106:6.733/--./0(1*66542(.-(+,,/28,)4140/..54353/7/05200++,3.&.&+*)15/340-,41335*(.(206400('39;263+/0*3045'/23*37521-34-/),..+$2*-1+,0-1*5/2+4+5.20/66*/-98:535+/3/5.5731+84/+1110*02-%22101*&..-)-2-4-25401-'49566124.7472651.**4,13$597/34920'853/14*-)'+/63-9:;22/,'+,*0/,1-43*017+015-75987../7&#-)-21-1*213031*%)1-,/1.$5.4028533/6'8::06-3535/8:74*4443+..50-0+0)&.298-75154*,5'10++0**1.06)2../,3,-(35750.6)-6-,1203405-8:8)+31771577/1.342(89833.%$.'%05+73+**$#:::1+50323-681::4,''.1,0+/118433-.'143,54//0148341-1.4.-7-205+,/++37319,:5869654,434:19.84833102(654)4*45,494*/2/0..1;297:7643333'3*7:814392:9:4*86:0+36:212399349),(128065042960*)(,.4230698;:6448242;5<483&/615396=998706*4393>9<6:*45/.4<6=66<::1:0224302287<426232;30,21*#2(-.956392487655150700-+&766022,9+4+323+159;3<1989986828894763(75+;8>;;54:77<3<:?;;,<:=;05547:359,=69-:>6>;41996<;961/1555:;88=-6;;;30(78:9&768/<138/33)=12*$4&2:0.2./03,-/-3637.34.-3,12($)316:::2191;7685113729944*6266.689-515432:;87:;656:43.-98050+442135.325947:061:5)+576207465547::;869:41255:856295485:78790.63498993359796546286695..2/11//256.74-395+038/2+435/4./-+,+1/(203/-3/.,.6++2411:894.9.196264+,3+553:4748.351/)+-3/2234)30.63445/332148,8995:4934-017$-73343474-974-9533174339:2510+0)254503/862461*0401686808:44)3687470.445.51937;76786'65:9;7516:9-05476566886(/6878621611641341342:4-0&/5+8733.(+/5+36*1*9:890-7:973,9463350585363326:37-+4777+*.4.50.76953.18763::/94799-8)3845.30//*54/06,,420&298:9:6(+354.735608:::784,918685/61:345545.4:32675/44841467:5748,37-97/5:85555*69-75:44.::5557+,3184,9878/25515952521//2120782926348021*4)5*72:5379615,581'035***').0+.22./492,50%253667337.3,1-1..,2.479436(//+/04:::4,31-074233-7630352500792/75:;769925.934:7723),45979946823132*264-478::795*2723::.3304+360,07)+3*27/9;6-1,5-0-2.&05/.9;53552,,216,9531.278574258:.975*4546884,5.9637263855899;*-08:84247683/%,01'43.0.3:.2:5:36:86:3850*+/...7/0).2....%%1*11-82.34&4234-,-267/-03/(4.2:74:2934 @rCer/1173/25_1512_CCS ATGGGGAGGCCCGCCAGGAGCAGGATGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTATACGGCGGCAGGGGCGCGCTGGGTTCTCGATGCGTGGAGGCGTTTCGGGCCCGCAACTGGTGGGTTGCCAGCATTGACGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATCGTCGTTAAAATGACAGACTCGTTCACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTGGATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTCTTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACCTCAACCATCTCCAGCCATCTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGTGCAAAGGCTGCCCTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTCTGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCAGGGCAGCCGCCATCGCTGTGCTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGCTCCTGGACACCCTTAGAATTCCTAGTTGAAACCTTCCATGACTGGATCACAGGGAAAAACCGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACTACGGAAGGAAGGACGGAACTCACCCCAGCATATTTTTAGGCCTCATCTCAGTGCCTGTGAGGGGCCTGCCAGAAAAGTCACTAACCCGTTTCAGTGTGGCCTTGTCCAGCCTTGTGTTTTCTGTAACCCCTGTTTGTGGAACGAGATAATGAGTCCTATTTTTCTCTCACGTAACGTGCATTTGCTCTCCTAGGACAGTGTAATACGTTTATGTGAAGTGAAAACATGCAAGACTGGTGGCCTGCAAATAGCATCCGTCAATCTGTGTTAACTGCATAGGGAGGGCTCTGCATAGTCCCTGCTATGGCGGTGTCATGTTGGATCGCTTTCGAGACTGTTTATCTGTCCTTGACAGTGGCTGTCATCTTGACTACTTTGTTGATTTGTTGGTATTGGGGACATTTGAAAGGCTGAGTTATTTTTGAATGTCATGTTTATGTCATAGACGTAGTTTTCGCAGCCTTGAATTAAACTGCCTTAAAACTCCTTTTGTGGTATAAGCAAGATTCCATGGACCCTGTCCTGGTATCCTTTTCCTGTGCGGTTGCCCCGTGTCCTCTGGCCTAGGGTTAAGTGTGCAAGATGACTACTTGTGAGTATTCAGAATGTTGTTCCTAATACATGCACTTGTTGTCCGTCTTCTTTAATCAAATCACGTCTTATATACAGCAGTCAGAGATGAGTACACTAGAATCATGGATTGCTGGAGGTCTTTTAATCTGGTGTTCTCGGAAGGGGGTGGATTTAAATCCTGAAATAAATATTTCATC + KKCKKKKKKGKKKKKKKKKHKKIKFJJKKKKKKKKJKKHKKKKKKKICKKKJJKK>?KJHKKKKCJKDHAKJ=KKK@KKEKKGKJAEJFHKJFKKKKKKGKKJJIKKK>KKK(KKIKKJJKKK:KKJ:KJIKKKKKFJKIKKJKKHAKK:CDJJKKKJKJKGKJKKKKKHKKKKHBKKJ;KCK>JKKKKHKKKKJJKIDKKKKKKKIKKIKJKJKKKKDKKJJKJKKKKKJKKKJKHKKKJ=KGK@KEECJKKEJJKJKJKKK?KKEKEKKIKKKKK?KKKKKKKJKIK7KKJKHKKJKKKKJKEKKKKKKKJJKKKJKKKCKKAKJIKKKKKKGKKKKKKKKJKKKKKKKKKKAIKJKKKKKKK@KKKKKKKJKKKKKKIKKGKKJKJK>JKFJKKKKKKKKCKHKIHKFKKKKKKKKKJK?KJJJKKKJEKKKKKJKJKKKKKJKIKKIKHEKAKKKJJKKKKDKIKKJKKKKHEKHKJKIKKIKKKJ?KKKKKKKKKKJKHKKKIKKKKKKKIFKKFKKEIKKKKKKKGJKKKKAKKKIKKKDJKKKJKJKKKKDKIKKKCKKKKAKJEKKEKKJKKHKJKJJKKJKKKGK/JKKJBKKKEIJKKIKKJKKKKKKKKKIKKKEKKKK7KJ=K=J;K;KHKKKKHKK1HKKKKKKKKHKKKHKKHGKKKKFKJ,JKKKGKKJ?KJKKKKKKKKFKJJKBJKKKKKKK@:K8KKKHJKKKKKJKHKKKKKKK@KKKKKCKKKKKIKKJ3KKKJJJKKKKKJKKKKKKKKKKKKKKK=KIKJKKKKKJK9KKKKEKKKKIKIKKK@KKKKKKKKKKKKCJJKJKKKKKEKKKK>KKKKKKKKKIKKKIK4KKHKKKKKKKJKJ6KKKKKKDHKJK)KKHHJJKJKKKKIIKKKHKKKKGKKKKKKKKKKKKIKKKJKJFKKKKKCKKKIKEKKKKKKBKKKKJKKKFKFIKJKKKKKKKKKIKKKHKKKKKKKKIJKKKKKKKKCKIKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKEKKKKKIKKJHKKKKIKKKKKKKK=KKIKKKKKKK6KKKKKKKKJKJKKKKKKKJKJGKKKKIKHKKKKKKJJKKKKKKKKKKKJKKKKKIK3KKKKKKBKKKAFKKKKKHHKKKKKKKKKKKKKKKKJKKIKKIGKKKKKKKKKKKKKKKKKKKKJKKKJKKIKKKJKKKKKKKJK+KKKKKKK4KKKKKJKKKKBKKKKKKKJKKKKKKKEHKKKKKKKGKKKKKKK?KKKJKKKKIKKKGKK,KKKKKKKKKKKK9KJKJKGKKCKKKKKKKKKIKKKKJKKKKKIKKKKKK@JCKKKKJKKKIKKKKJKKKKKKKKKKKKKKKKKKKKIKKKIKKKDKKJKKKAGJKKKKKIKKKEKKIKJKKKIKKKKKKKKKKKKHJKKKJJDCKKKKKKKKGKKKKJKKEKKK4KKJEKJKJKKKKKKKKKGKIK0KKKKKDKKBKKKKKKKKKKHKKKHKKKKHKKKKKK @rCer/1174/1517_56_CCS AAGGAATGTTCAGGCAGAAGAAATGGTAGAGTTTTTCTTCAGGTTTAAAGGGTATGTCTTGAACTTGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAAGGACAGGAGCCATTGTGGACGTTCCATTGTGAGGAGCTGTTGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGTCCATTGTTCCAGACCGTAGGCGAGTTGGTCTGAAAGCCCCGTATATTCTCGAATTTCAGTGCGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGTCGTGGTCAGCGTGAGCTGATTATTGTGACGACAGACTGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCTCGGATGCTGCCCACTTCAGTACCTGCTCCTTACTCTGGCTGTTCCATGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACGTCAGATGTCTCTGTTGCTGCGCCGTCCCTGGTCGTGAGGCTATCTGTGATGTGTTCTACTACATCCCGATTGTTGGAGAGAGCAGCCAAAATGAACGATGCTTTGGTGTGGTCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGTGATGTGTCTGCTTACATTCAACGAATGTCATTTCATCACTGAGGACAGATCTTCTTGGAACAGAATTGTTCTACAAAGGTATCCGCCTGCATTAACGTTGGTCTATCTGTGTCTCGTGTCGGATCTGCTGCCAAACCAGGCTATGAAGCAGTGCAGTACCATGAAGCTGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTGGTTCTGACCTCGATGCTGCATCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGCAGTATTCTCCCATGCTATTGAAGAACAAGTGGTGTTATCTATGCGGGTGTAAGGGCTATCTTGATAAACTGGAGCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACAAGCCTGTTGGTACTATCAGGTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAGTTCTTGCTGGATTTGAAGCTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAGGTTACTCTGATACTCTTATGTACAGAAATCACATGAAAAATAAAGGTTCCAT + 9'73;9::7692$%056:4661035234-634/11$+80648(%4&:8115,3.103&-+350/81':70('4::;4.4:03)427363/206771:475-,,40/3$76::;:7792805.2,.67:0.2.1%/831-/54-+0)76+$0/+:1)@.C7$64,98951:5477B-B#>74;7ADDF<(CA8(..G8>'7:369>:<;+BCB>(G@-@+88)&3*$B97#%-:?7C<<@119;3E=E3>CB=GE>?<;9'+5;(,E;(7AAC@G@284<*F@B@@E:?4?@JI6*@JG;AI=2@==>6>@G0BD78G:;D35>:?AABC.4?;?@-?=A=C,=C@:A=D8D'<16.9));BD/CB<=FDCC6;A?+D)?@7G3195(-*/,78)AE;E:)6?'?ACBC35>7F8@9CB;@B65=>8BCF1BB/3DC6C:=-<@C5AEA=38A=C<:@:3B9A0*185:?A@8B8;6:$A@:?4;E:AC<5BCG5:B;CB;<'98>8$=?)@BDAE@D4,>C6)-)4+706:)@%6481<4;&%99'>;<6?A6>07;<.4::7/F:DD@*ECB8@=?A;>ED+628&93&<)>?>E:C?/CF)CF/>+?@EB<@@C*66-;=.04%'#4.:>:=>:A@51<5@?90B4EA=-=23;DC88,/B@<1C@#'.=A='?91C.5:CE)B1EA?C8;74;4.AC7B29@@9A-766,B?>A>?A1?0558<80'=5068:38>#2=0=07A.;9:73B1?@A2=$A4)107(5D=)=):3995=<>%=A@*B4=$/0C@5AA@C2?;AD?;ABA.96$;;1.-->.9=2*;EBF?==@BAD;4>BDGBAAB5/)?;9DCC.*;87%BC/4@>:&8>7)A+.D:0;8"1&D+?@=<153?;>3ACFF>58*;BC@7F192<<$A?:F;BBCFE?D>@DDA2@A@E@88E=;488;=;8AB#4D:8?45-8D=CFE)?E>4B::A>8:?G8C?E@<6?0>@F97;?=/@$/5@18;A8>A<9>,G>9@&>>@>=<0BEFD,6@A&;&D::&;; @rCer/1175/3110_63_CCS ATGGGAGTGACGCCAGGGGCGGGCCCGCGGCGCGGGCGGGTGAGAGGGCGCGGCGGCAGATGGGGTCTCACTGTGTTGCCCAGGCAGGTCTCAAACTCCTGGCTTCAAGCAGTCCTCCTGCCTTGGCCTTGCCAAGTGTTAGGATTACAGGTCCACCTGGGCTTACGAAGGCACAGATTCCCTGTCCACAGCTCACAACCAGATGCACCAGCAGGAGTCAACATCGAGCACGTCCTTCGGGCAGCACCTCCTCTGGGCACTCCCACGACCAGTGACCAGGAGTTAAACTTTGAGGTGTGCCCGTGATGTTGGACCACCAGGACTTAGAAGCCGAAGTCCACCCCTTGAAAAATGAAGAAAGAAAATCGCAGGAAAATCTGGGAAACCCATCGAAAAATGAGGATAAGTTGAAAAGCACACCTCCACAGTCCCGGCTCTCCCGATGCCGAACGGTGGCGTTTTTTCTTTCATTGTTTCTCTGCCTTTTTGTGGTGTTTTGTCGTCTCATTCGTCATCCCGTGTCCAGACCGGCCAGCGTCACAGCGAATGTGGAGGATCGACTACAATGCCGCTGTTATCTATGATTTCCTGGCTGTGGATGACATAAACGGGACAGGATCCAAGATGTTCTCTTTCTTTATAAAAACACCAACAGCAGCAACAATTTCAACCGATCCTGTGTGGATGAAGGCTTTTCCTCTCCCTGCACCTTTGCCGCTGCTGTGTCGGGGGCCAACGGCAGCACGCTCTGGGAGAGACCTGTGGCCCAAGACGTGGCCCTGGTGGAGTGTGCTGTGCCCCAGCCAAGAGGCAGTGAGGCACCTTCTGCCTGCATCCTTGTGGGCAGACCCGGTTCTTTCATTGCAGTCGACTCGTTCACAGGGGAAACCCTGTGGAACCATAGCAGCAGCTTCAGCAGGAATGCGTCCATCCTGAGCCCTCTGCTGCAGGTGCCTGATGTGGACAGTGATGGGGCCCCAGACCTGCTGGTTTTCACCCAGGAGCAGGAGGAGGTTAGTGGCCACCTCTACTCAGGCAGCACCGGGCACCAGATTGGCCTCAGAGGCGGCCTTGGTGTGGACGGAGAAAGTGGCTTCCTCCTTCACGTCACCAGGACGGGTGCCCACTACATCCTCTTTCCTGCGCAAGCTCCCTCTGCGGCTGCTCTGTGAAGGGTCTCTACGAGAAGGTGACCGGGAGGGACGGCCCGTTCAAGAATGACCCGCACTGGGAGAGCATGCTCAACGCCACCACCCGCAGGATGCTTTCCCACAGCTCGGGAGCTGTGCGCTACCTGATGCACGTCCCGGGGAACACCGGCGCAGATGTGCTCCTTGTGGGCTCAGAGGGCTTCGTGCTGTTGGACGGGCAGGAGCTGACACCCCGCTGGACGCCCAAGGCAGCCCATGTCCTGAGAAAACCCATCTTCGGCCACTACAAACCAGACACCTTGGCTGTAGTCGTTGAAAACGGAACTGGCACCAACAGACAGATCCTGTTCCTGGACCTTGGCACTGGAGCTGTCCTGTGTAGCCTAGCCCTCCCGAGCCTCCCTGGGGGTCCACTGTCCGCCAGCCTGCCCACCGCAGACCACCGCTCAGCCTTCTTCTTCTGGGGCCTCCACGAGCTGGGCAGCACCAGCGAGACGGAAACCGGGGAGGCCCGGCATAGCCTGTATATGTTCCACCCTACCCTGCCACGTGTGCTGCTGGAGCTGGCCAATGTCTCTACCCACATTGTCGCCTTCGATGCTGTCCTGTTTGAGCCAAGCCGCCATGCTGCCTACATCCTCCTGACAGGCCCAGCAGACTCAGAGGCACCCGGCCTGGTCTCTGTGATCAAGCACAAGGTGCGGGACCTCGTCCCAAGCAGCAGGGTGGTCCACCTGGGTGAGGTGAGCCAGACAGTGATCAGGCCATCAGGGACCGGTTCTCCCGGCTGCGGTACCGGAGGGAGGCGTAGAGGTACGCCCGCCAGAGCCTGTGGGAGAGACTCCGCCTGCTGACACTAAACGTCCTGGGAAGTGGGCCCCTTCCTGGGTCTCCGCACTGACTCCCCCACTCCTGACCCTGGTGATGGTCGCCACTGGGCAGTAGCGGCCTTACCAGTTCTCCATGATTGCACCCAGGGACGTGCATGGGTGAGGGGACACCCTGGGCCTCTCTCCTGCCCAGTGTCCTCCCTGAGTCCCCACACACGGTCTCACTCTGCACCCCACCAGGGTCCCGCTCACACCAGACAGCCTTCATAGTGGTCTCCCTGGGCCACCTTGGGCAGAACTGGGTCATGCAGCACCCCATCCTTACCCAGTGCCCTCTCCTTGCCAGCTTCTCCCCAGGCCAGTGCGTAGAAGGAGCCAGGGTGTCCCCAGGACAGGCCATCCCCCACCCCATCCTGTAGAAATCCATTCCCCCTTTTCCTCCTGTCCTTCATCTCCCAAGGAGTCATGGAACTCAGGGTACTGGGTCCTGGGGCAGCCTCAGGGCCTCAACGGGAACCTGAGACAGCTCCAGCTTCCCAGCCCTTCCAGGAGCTGCAGGGGGATCCTCTAGCATGGGGGGTGTGACTTGGTTCCTTTGTCCAGGCCCTGTGAGGAAGCCCCCAGCAGGATGGGTGGGGCCTGCTCTGGAGCTGAGCCCGAGGCTGCTCACAGGTGTCCTTAGTGGAGTTGCAGCCGTGTGCTGGCTGCACGTGCCGTGAATATCCCGAGGGACTGGCTGTGGGATGCGTGTTTGGGTCAGGCTGTGCCCTCTCAGTAAACACTGGAGCTGCTCCATCCCTGAAGAGGCCCCGTGCCCCAGGCATGGCACGCACCTCGCCTCTCCCTTTCCGGTGCTCACACGCCCGCCGTGTCACCTGATGCAGGTCTCACCTCTGTGCCTTGCTGCTCCTGAGGCCCAAGGGCAGCCGTGGGGCTCTGTGCTGCTCGGACCGCCCAGGCCACAGAGCCTGAGCTTCGTAGCCAAAGCAGCCTGATGACCCACCCACCAAGGAAAAAAGCAGAATAAACATTTTTGCCTGAAAAACCCCGGTGGTCAGGCTGAGCC + 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@rCer/1179/0_1854_CCS GAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGATCAAGATGAAAACCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGAGAGACTGTCCTGAGCAGATTTAGCTGGGGGCCGAAGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCATGGCTAGACGCTGAAAACCACCTAGTTCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCTAGGGTCAGGCACACGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCTCCACCCTTGGACTTTCTTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGACGTGGTGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCAATTAGCTGAATTCGCGTGTGGCAGAGGAGGAAAAGGAGGCAAATGTGGCTGGGCAATGGCCTCACACAGGCAACAGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAAGCCCACAGCCGGAGAGTCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGCAGTGCACAGTGGCCAGCACTAACCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGCACAGGCGTGCACCTGCTCCGAATTACTCACCGAGACACACGGCTGAGCGATGGCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCTCCCTAACCTACTGACCCACCTTTTGATTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCTCCCGAGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAACAATAAACTT 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@rCer/1183/2201_58_CCS ATGGGGGACGTCAGCGTCAGCTCCTCCACATCCATGCCGTGTTTTAGTTTGTGCCTCAGCTGCTGGCTACAGCTTCCCGGGGGAGCCGGGTACCACCCGGGCCTGGAGACATGAGGAGGCAGGGATGTGAGGGGCGGGGGACAGGACAGCCGGCCTTCCGTTAAATATCTGCTCCTCGCGCTCGAGCCTCCTGCCTATTGTCGGGCCGGAGGCGAGCCGACACAGCGCCAGCTTGTCAAAGGGAAGGAAGATGCCGCCCTGCACGCCCGCCGCGCACAGAGCATAAAGAACCTGCGCTGAGGAGGCAGGAGAAGAAAGCCGAATCCATCTACCGCCGGGGAGCCAGAAGATGGAGGAAGCTGTACCGTGCCAACGGCCATCTCTTCCAAGCCAAGCGCTTTAACAGGAGAGCGTACTGCGGTCAGTGCAGCGAGAGGATATGGGGCCTCGCGAGGCAAGGCTACAGGTGCATCAACTGCAAACTGCTGGTCCATAAGCGCTGCCACGGCCTCGTCCCGCTGACCTGCAGGAAGCATATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTGGATGACAAGAACGAGGACGCCGACCTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAACATGACAGCATTAAAGACGACTCTGAGGACCTTAAGCCAGTTATCGATGGGATGGATGGAATCAAAATCTCTCAGGGGCTCGGGCTGCAGGACTTCGACCTAATCAGAGTCATAGGGCGCGGGAGCTACGCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTGAAGAAAGAGCTGGTGCATGACGACGAGGATATTGACTGGGTACAGACAGAGAAGCACGTGTTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGATTACATTCCTGCTTCCAGACGACAAGTCGGCTGTTCCTGGTCATTGAGTACGTCAATGGCGGGGACCTGATGTTCCACATGCAGAGGCAGAGGAAGCTCCCCGAGGAGCACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCCCTCAACTTCCTACACGAGAGGGGGATCATCTACCGGGACCTGAAGCTGGACAACGTCCTCCTGGACGCAGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGCCCTGGCGACACAACAAGCACTTTCTGCGGAACCCCGAACTACATCGCCCCCGAAATCCTGCGGGGAGAAGAGTACGGGTTCAGCGTGGACTGGTGGGCACTGGGCGTCCTCATGTTTGAGATGATGGCCGGGCGCTCCCCATTTGACATCATCACCGACAACCCGGACATGAACACAGAGGACTACCTTTTCCAAGTGATCCTGGAGAAGCCCATCCGGATCCCCCGGTTCCTGTCCGTCAAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGGACCCCAAAGAGAGGCTCGGCTGCCGGCCACAGACTGGATTTTCAGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGGGACTTGCTGGAGAAGAAGCAGGCGCTCCCTCCATTCCAGCCACAGATCACGGACGACTACGGTCTGGACAACTTTGACACACAGTTCACCAGCGAGCCCGTGCAGCTGACCCCAGACGATGAGGATGCCATAAAGAGGATCGACCAGTCGGAGTTCGAAGGCTTCGAGTACATCAACCCATTACTGCTGTCCACCGAGGAGTCGGTGTGAGGCCGCTGCGTCTCTGTCGTGGACATGCGTGATTGACCCTTTAACTGTATCCTTAACCACCGCATATGCATGCCAGGCTGGGCACGGCTCCGAGGGCAGCCAGGGACAGACGCTTGCGCCGAGACCACGGAGGGAAGCGTCGGCAGGCGCTGCTGGGAGCAGAACGGTCCCTCACACCTGGGCCCGGGCAGGCCAGCTTCGTGCTGGAGGAACTTGCTGCTGAGCCTGTGTCGCGGTGGCCGCGGGGACCCTGCTGAGGGGCTGTCATGCAGTTTCCAAGGTGCACATTTTCCACGGAAACAGAACTCGATGCACTGACCTGCCCCGCCAGGAAAGGGAGCGTGTAGCGTCCTGAGGAATAAAAGTTCCGATGATGT 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rCer/1184/1647_55_CCS ACACACTTGAAGATCTCTCCGCAAGAGTAGATGCAGTTAAGGAAGAAAATCTGAAGCTAAAATCAGAAACCAAGTTCTTGGACAATATATAGAAAACCTCATGTCAGCTTCTAGTGTTTTTCAAACAACTGACACAAAAAGCAAAAGAAAGTAAGGGATTGACACCCTTCTGTTTTATGGAATTGCTGCTGATCATTTTTTCTTTAAAACTTGGATAGATTCCAAAAGTTACAGTACCTTTGTGGCTTCATTGAATATTTATGAAGAAAATGTCAGATGTAGACAAAAATAACACAATAACAGGAGGCTTCCATAAGTTGTGTATTATGTTAGTCTATGAAAACGTGCAAATGTATTGTAGAGACTTTATAATTAGAATTGCATATATTTATGAACTTAAAAGATGAATGTTTTATCGAATTTGTAGTTTAGCACTGTCTTTTATTATAGGATTAGTAAGATATAGAAGAAAATAACCACCATGTTGTGAAAAGTGACTAAAATCATGTACTAAATGCACAGCTTTATGTACCCTGTCCACCATCTTGTGCCTCTTTTCCATTTGCCTCTTCCTTCCTATTTCCCTTCCCTTAAGGAAAAAAATTGGTGTCACATTTGTAAAAGTAATTTTAATAGTTAATCATCTCTGAGAGTAACCTGTATTTTCATTGTTGAAACAACCAAAATAAGATACTGTCTCAGCTAGGGTTTGTCATTTGTGTATTTAGTATTAAGATAGGAATGCTAGTGTCTCTTTAATTAATTGGAAATAGATGGAGGCTAAAAATGAAGGTTTTTCTTTGAAACTGAATTAACTTGAGAATATTTGTTGTTAAAAACTTCTTTTTGCACAAAATAACTCATTTGTATTATCTGAAAATATATAATTTCTGGTCATGTGTATGTTTAAAATAGAAAATTTTGAGGAAAAATGGAAATAGGGTGGAAAAGTACTTGGTAAACAGTAGTAACCAAACTTCAAATATTTTCACTCCAGATTTGTGTTTTCTCTGGCACAGAGTAGATCTTTTGGGAAATATATATAATTAAGTTTGACTACCCTGTGTAAGCCACATCTGGATGAGAACAGTTACAAAGAGTTTGGTCTCTAAGTTGATTCGTACCCAGCAGGTCAACTTTTGCAAATTCCGTAACAGTGTGTTAGTATTAGAATAGTGAATAAAATGGGAGTTTTACATGTATACTTATTATCTTGCTCAGTATTTTATCTCACTTGTTCTAGAATTTTCTGTAAACCCTGCTACTGGGTTTGAAGAGTTTTAGTCATCCTTTAAACAATTTTTAAAAATTTAGCTTGTAGATTCCATTTGGTAAGGAAATCAATAATGGAAGTAATGCTAAAATCTTATAATATGAAAAGAGATCCACTCATATAGCTTATGGTTATTAGATTTGGGCTACTTTTAATCATGGAATAATCTTATGTATTGGTGTAAGAGTTGATGAATGACTTTAGCTGTATGAATATATAATAGTGAAACTGCAAACATTTTGCATCCCTTTTGTGACCTAATTTACAGACATTTAAATTGTGTTGCAGTTCTGCTTTGCTGTTTAATAAAAAGCTATTT 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rCer/1185/25_2912_CCS ATGGGGCCGTCGCGCGGTGCAACAGATAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCTTGCGGGAAACCAAGATGGCGCATGGGGGTTCTCCAGGGCGCAGTTGGCACCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTATGGCCAGTCTGTAGAGGATGATTATTGTATTTTCGCATCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTGAGCCTGTAGAAGAATAGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCGTGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGAATGAAATATTAATTGAAGCAGTTCTGAAGAAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAATTGAAGGACAAGAATGAGGGAACAGTATCTACAAGAAAGATGGCAAAAGGAAAACCAGTAGATTCCCAGACATCGCGAAGTGAATCTGAAATTGTGCCAAAAGTTGCTAAAATGACTGTATCTGGAAAGAAGCAAACTATGGGATTTGAAGTGCCTGGAGTATCTTCTGAAGAAAATGGTCATAGTTTCCACACACCTCAAAAAGAAACGGCCCATTGAAGATGCCATTGCTTCTTCTGATGTTCTTGAGACTGCTTCTAAATCTGCTAATCCACCCCTGACGGTTCAAGCATCAGAAGAGCAGAGTTCAACCCAGCACCGGTGAAAAAGTCTGGCAAGCTGAGGCAGCAATTAGATGTGAAGGCGGAACTGGAGAAGCGGCAAGGAGGGAAGCAGCTCCTCAACTTGGTGGTCATTGGTCATGTTGATGCTGGGAAAGTACTCTGATGGGCCATATGCTTTATCTTCGGGTAATATAAACAAAAGAACTATGCATAAGTATGAACAGGAGTCTAAAAAAGGCTGGCAAAGCTTCGTTTGCATATGCATGGGTCTTGGATGAAACTGGCGAAGAGAAAGGGAAAGGGGAGTAACCATGGATGTTGGTATGACAAAGTTTGAAACCACAACCAAAGTTATTACATTAATGGATGCACCAGGCCATAAGGACTTCATTCCAAATATGATTACAGGAGCAGCCCAGGCGGATGTAGCTGTTTTAGTTGTAGATGCCAGCAGGGGAGAGTTTGAAGCTGGATTTGAGACTGGAGGACAAACACGAGAGCATGGACTCTTGGTCCGTTCTCTGGGAGTGACGCAGCTTGCTGTTGCAGTTAATAAAATGGATCAGGTTAATTGGCAACAAGAAAGATTTCAAGAGATTACTGGAAAACTTGGGCACTTCTTAAGCAAGCAGGTTTTAAGGAGAGTGATGTAGCTTTTATTCCTACAAGTGGTCTCAGTGGTGAAAATCTAATCACAGATCTCAGTCAAGTGAACTCACAAAATGGTATAAAGGACTATGTTTATTAGAAACAAATTGATTCCTTTAAGCCTCCCCAGCGATCTATTGACAAGCCTTTTAGATTATGTGTGTCTGATGTTTTCAAAGATCAAGGATCTGGATTTTGCATAACTGGTAAAATTGAAGCTGGTTATATCCAAACTGGTGACCGACTACAGGCAATGCCTCCTAATGAAACTTGTACCGTAAAAGGAATCACTCTGCATGATTGAACCTGTTGATTGGGCAGCAGCAGGCGATCATGTTAGTCTTACTTTGGTTGGATGGATATCATCAAAAATCATGTTGGCTGCGTATTTTGTGGCCCCAAAGAACCTATTAAAGCTTGCACTCGCTTCAGAGCCCGAATCCTCATCTTTAATATTGAAATTTCCTATCACTAAAGGATTTCCTGTGCTGTTACACTACCAAACTGTCAGTGAACCGCCGTTATTAAACGATTGATTAGTGTCTTAAACAAAAGCACGGGTGAAGTCACAAAGAAAAAGCCTAAGTTTTTGACTAAAGGCCAGAATGCATTGGTAGAGCTGCAGACACAAAGACCAATAGCTCTTGAGCTGTATAAAGACTTTAAAGAGCTGGGGAGGTTCATGCTACGTTACGGTGGTTCTACAATAGCTGCTGGTGTTGTCACTGAGATAAAAAGAATGATGGGTCAGAATTTCTGCGTGTTTCCGGATACAGTGAAATAGCTAACCTCTGTTTCAAAGAATCCAGTCATTAAGTCAAAGGAACAATGTGCAATTGATATTTTTTTAGATGAGAGGAAAAATTAAAGCTAAAATTAGCTGCAAAGAAAGTATTAATAATCACCTCTGCAAAAAATTATAAGTTGCCAACTGGCAAAGAAAGGCTAATGTTTAAAAAACAACTTTCCCTTTGAAATGTTAGTAAATGGATTTACTTCGCTGAGATTTATGGCAAGTGTCAAAAATAGTATCCGAAAGATACTGAATCATCATGAAATGAACTCTACTTCTGGCCAAAGCACAATGTATTTGCAGTTTTCTTCTTTTGATTCAATTATACTGCACATGTTTTTAAGGAAAAGTAACTTAACTGGGTTTTTCAGGCAGTTGATATTTGACCTAAGCTTTTTTTTTTTTTTCCGGTTAACGCTAAGAAAAGATTTGGGAAAAGGTTATAATAAAGGTATTTTGTGGTGACCATAAGAATGTCCCTCCCCAAACAAGTAAACTTGTGAAAGTTTAATTTGGAATTAGTGGAAGCTGTTCCTTTGAAAGCCAAGATATTATTTAAGTTGTAAAGCCAGCTAATAAAATGCCTTAGTTTGAGCAT 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*+),,+&%$'*)(*('%*,,%**,,(&'*)'),+-+++*)-',+,++,),,+,(*(*++)-,-((+*('+-+-.(++-++*)-+++'**-,,.,*,,+)*&+))+)+++,*-(+()(,(+-,,,+(**),,,+,*$(''),-+-)-+,++&,),$(,,+*&)+,,*+-++&,+*)*&+,),+++(+(,*,,',,+&)$))),,(+,+-(-+)+***&'',++++,.,)$+++&+-'&(*()*(%&&'#$')+(-*)*)*)(*)%&''%))',"%)('%"'(()'#(*+),*'&('*,,+)&%)*(%-+()-')*$())**'&',-'+&*(,'#&))(.,+*+'%+)+,)$$')&(-*&)()**)+$*&'+-'+&)**&('*))*)+-($('(+*($(%'&)**,*+#"%''+,*&**,)+***#&&'$&%()%*,*-+)'))'$$&',,')+,,)(%)),-+++-,+++').,+#%),+,.,+(-#'&*'*,)+,*&++,($+%$*+,(,+)---*+,((*(*,-)-*'-*'*)+),*-(,,,,''*+)++('(+-,,+),()+#*+),,-,++,().-+))-+%-*'),),*++&'***)))'(+-,+,,,()),,+&)+-+*-++.*--*)+,)(*(+,,.,+-))('',+..+-*'+(-(---+&-'*&).,,,+&),-+(*-)+,*,.,)++*%+,))+('++*'--+*.,,++,'('-,,+-,*,,--,.+#)*'&+.,(--,)),+)**)(()('((&+)*&$#%)(&+&*+,,+$&*-,('+,,&++%).--.,$**-*&,+',)+,)(&+++++*%*)(+,,-+,')+-*'*,++&++*++,,(-,+&+(*,).(*-,-++,++&%$$*+&()+'++,--(,--,----,-),,+(,+,*.,%,+(+,.-+++-,-,-&,,-,*.-,+,$)*-,+(-++,+,),,,,.,*$(*),,,(()($*%*%',+++'+,.,--,(+.,%'*,(#(#"%*(*(,,')*+,(--+,,*,+--+,-((+,-*#,*)+,$((&*++)...,(**,(,)++,%++-,-,(,+-)+&&)*,&**+*))--*)-*',*,,(+*,%,)%'*,,'+(+)%,-+-+,+-&$)',,+*'*,,',#$##$$"$$#((%&()(&(')()''')&((&(%'#'''(($))(#(''$%&%($&$'%(()'%&&())''($(')((()((&''(('($('%&&&))(&(')'*,-&-*#'),-$%'*,,.-*,(,,..--.,-.-+*(+)-,-),-)*--.--,&(+((-,,(((+),*(')$**(&,)((-,,+..--*),-))+(++-+-+''+),),+++&*,+--++.--))-(*.-,-+*,,%+,&','),*,*,)*'*&,+-,'',+,(*...,(+,*-+-.,-'*&)*-(*-+)'$)-.)'$*,+-.--+'*-,-,(,(--,)+,'---+&#+&('*.,(+---,)*&+,+*-)-*(++++-+,%*')&)++*-.+.-,,-,--)--*--+,$)+$)#+,,*-*$,+-'&$)+))(+(++,(+*---.-)*),*-..+,.*,+(++%&%+*+--++.-*,++$+*+*.,$,)*,.--)+,+-,+*,+...---,-+,--)--*+,.+,-).,-%+,)-+)+()((+++-),--...+$,+*+,-(+(,(+--')*',,)()+-*,,'(*$',++%,((-+-+,.+.--+*)-'-,,*+(*-+)*)+--+--(,,(*+,,.,-.,(+'*)-,,),,-,*,-+$+)++.-.-*+),,+,(+,-*$&)'.$(-,'-,+)(),-+(,*+--*+)+,*%++,,&**-,(,.-,&+))+)+#+#'')-,+,,-+)$*('$&)$(-,.,-+-+,-(%$**(*&%)+-+-)--,,,+.+(-.,.,*-+.---)))++),,+(+'(-,+(,+)+-*+--,-++.-(,,+'+'%**'--,&+*)($,+*.-+.-*.------))(,,)(,,('$++*,),-*+-+)'$,%',,,,-,.+.,,-,',,+(*(,--)(,-%,,'%')*)*)'$')(+-.-*$%(&*))',(*,,)-)&),&*+++&(*((-.+*,.,('+,+)+)-+.+-,+%',,&+&),,*,-,*,-,-.----,+'---+---**,*,,+$*(.,&,+,+(+)&+***-.-.+-)*+-+((%))+'**),&(+++(&,),,+$*+##))*+.,---,)+,-,+#)***+-.,(+,)**+,&((+$)+)$'$*,+$++'+&-+'+-,*+-+-+,&,*-,.*,(*',+--+#+,*).-*----++-.-.-+--.,-.,.--+,-,--,-(,*,+-(-,----+-+***+,$"),,.-+-'-,,',%,+*)+-,-,+-+,.+$*+,,()**.-*-,'(+-'()*-(-++,*(,'+)*,(,((--.--+)%+-,,+..,.-)-,-,$(&$+*))%%$'&#(((+*%*+()*,,*%++#'&)*)&+''*--,(,,)--,*,&(,+('+-*(,-+,+-,-,,,&)(+)+)-*#&#(%&'*&*%*(+--*+$**.,---.+*++(+-.,--.-.,,*&((+&)+,,,(-,,-*,&+,*'#(%#*++++++&&+'+--,--,-+,)+,$+++**-+-&,,-)+,.--.,-)*),*)-...++)-+))'+,,,))),)')*,'+,+&+'+----,,-,,(&,,-*--.---,)+,&,,,,)(+,),,$((+-.,.-((,-,..-.,)%*+,+*)-+)*(+%&*-+,-+-)%,,-,...,,-((,,(',,,+.+$*),,,+..+-)--**&,)-)#(*)).,%),(-,,)-+'%,,,)-$++-+('-,+*.,.,,-(&(++-+.++(*$+((,+,++%++-&,+)--)'(,) @rCer/1186/0_783_CCS ACATCGGCCTCCAGGAGCCAGGCCGCACACAGGCCTCATGTGGACTCCGTCCCCTCCAGGTGAGGCCGCAGCGTTTGACGACGAGTGGCGGCGGGAGACGTCCCGATTCCGGCAGCAGCGCCCCCTGGAGTTTCGGCGGCTTGAGTCCTCAGGGGCGGGGGGACGAAGGGGCGGAGGGGCCTCCCGCTTGGCCATCCAGGGACCTGAGGACTCCCCTTCCGACAGTCCCGCCGCTATGACTGGTGAGGGCCCCGGGCCTCAGCCTCTCTTGTACAAGCTGAGAGGCTAATACTCCCTGAATAACTTTTTCCTCTCTGTTCCATCCCAATTTTAATATTAAATTAACAGGCAAGCCGGCCCCCACCTCTCCCTGGGGGTCTCAGGGAGAACCTTCCCTACTTTTTCCTTCTTTAATCCCCTTACCATGATGACTTCGCCTCTGCATCTACTAACTTGATTTTTTCATTCTGCTGCTCCATCTTCAAACCCCCTCACCTTTCCCATTCTACTCCTGCCATGCATTGAAGGGTCTTTTGGGGTGAGCTCTGGGTTTAGGGGCCTCCTCCATCCCTCAGCTACCCTGGATCTTTGCCCACCTCTTCCTCAGAGCCCCCACTGAGGGGCCGTAGCCCTGTCTAGGGCTGTGGAAGGAGCAGACTGGTTCCCAACTCTTTCTTCCCTACTCCTGCCCACACACATCACCAGAATCTTCCCTAAACCCTTCCCTGCCTTTATTTTTTGATTTGTGCAACTTGTAACTAGGTGTTTATGGAATAAAGGGAG + S0,53).+.)(&3.514.1/',05/-4383/43)(/-1/-/(0136478*(006285/18751)11768'152.787048/94).+266+0++429952'*,-,&1155:.43(234.43'2.33020(+0345661',%(/.-4647+,4+5212+1*.)')$1&.$'*-*--.&))-,-1*03.003&./0,,-*)..0454+.-(*,3.*/153/%10/-*2+%.+./12201/+%-0&/11+&)-$0.*(3)%.3653,/'(+-/23342-0.))/./,(,'#!!!"!""0.+*.2-*,)$/-+))1/*0/-)!,!,(-#/.)-$)($''&)+'*0,+/20$(+/)/4/06-5*423+-/*3./+-/3,30/,..3.*034.+#*+%!/%0/*,((1556&2(/,'//+.10634+41+/*./'/,053235,-/1-3($'2+,,0).,'-*/$--.+(11/0).,&,).-*/4,2-0($),)-*,+/*,*0*10)4.()3/&-&.0503/5(4034-6146.3344.44244562331-+-..55(4/0*326+*1*/5.6220664532300,0,,*-000,0/2+562+,55521.03).40+-/252++04'132/65420*,3.-30//+4413-224+246055/140-0-.3'31)341032+5%3*1-(321/1.1)--.-()&03--002/305+0//.1/-+.0),)-1*5014-2&-1'$32441.1-455452$,--.+,,2/(+2431)//,.,6052+-/&,%), @rCer/1189/25_1559_CCS ATGGGGGGGGGCTGGCCCCAGGAGGAGGAGGAAACCCTTCAAAGAAAACAGCAACAAGCTGAGCTGCTGTGACAGAGGGGAACAAGATGGCGGCGCCGAAGGCGAGCCTCTGGGTCAGGACCCAACTGGGGCTGCCGCCGCTGCTGCTGCTGACCATGGCCTTGGCCGGAGGTTCGGGGACCGCTTCGGCTGAAGCATTTGACTCGGTCTTGGGTGATACAGCGTCTTGCCACCGGGCCTGTCAGTTGACCTACCCCTTGCACACCTACCCTAAGGAAGAGGAGTTGTACGCATGTCAGAGAGGTTGCAGGCTGTTTTCAATTTGTCAGTTTGTGGATGATGGAATTGACTTAAATCGAACTAAATTGGAATGTGAATCTGCATGTACAGAAGCATATTCCCAATCTGATGAGCAATATGCTTGCCATCTTGGTTGCCAGAATCAGCTGCCATTCGCTGAACTGAGACAAGAACAACTTATGTCCCTGATGCCAAAAATGCACCTACTCTTTCCTCTAACTCTGGTGAGGTCATTCTGGAGTGACATGATGGACTCTGCACAGAGCTTCATAACCTCTTCATGGACTTTTTATCTTCAAGCTGATGATGGAAAAATAGTCATATTCCAGTCTAAGCCAGAAATCCAGTATGCACCACATTTGGAACAGGAGTCTACAAATTTGAGAGAATCATCTCTAAGCAAAATGTCCTCAGATCTGCAAATGAGAAATTCACAAGCACACAGGAATTTTCTTGAAGATGGAGAAAGTGATGGCTTTTTAAGATGCCTCTCTCTTAACTCTGGGTGGATTTTAACTACAACTCTTGTCCTCTCGGTGATGGTATTGCTTTGGATTTGTTGTGCCACTGTTGCTACAGCTGTGGAGCAGTATGTTCCCTCTGAGAAGCTGAGTATCTATGGTGACTTGGAGTTTATGAATGAACAAAAGCTGAACAAATATCCAGCTTCTTCTCTTGTGGTTGTTAGATCTAAAACTGAAGATCATGAAGAAGCAGGGCCTCTACCTACGAAAGTGAATCTTGCTCATTCTGAAATTTAAGCATTTTTCTTTTAAAAGAAAAGTGTAATAGACATCTAAAATTCCACTCCTCATAGAGCTTTTAAAATGGTTTCATTGGATATAGGCCTTAAGAAATCACTATAAAATGCAAATAAAGTTACTCAAATCTGTGAAGACTGTATTTGCTATAACTTTATTGGTATTGTTTTTCTAGTAATTTAAGAGGTGGATGTTTGGGATTGTATTAGTATTTTACTAATATCTGTAGCTATTTTGTTTTTTGCTTTGGTTATTGTTTTTTTCCCTTTTCTTAGCTATGAGCTGATCATTGTTCCTCCTCACCTCCTGCCATGATACTGTCAGTTACCTTAGTTAGTAAGCTGAATATTTAGTAGAATATGATGCTTCTGCTCAGGAATGGCCCACAAATCTGTAATTTGAAATTTAGCAGGAAATGACCTTTAATGACACTACATTTTCAGGAACTGAAATCATTAAAATTTTATTTGAAT + HJ9KKKKKKKKKKKKIKKKKKKHGJFFKKFK9KKIKKKKKFKKKAKJKKKKKFKKIKKKKKKKKKKKKFKKKKKKK@KKKKKKKKKKKHKKJKKKDKKKKIKKIFI?KKKKKKKKKKKKIHKKIKJKEKKKKKKKKKIKKJJKKKKKKKKKKKKKKJDKKKJKKKEKKKJIKKKKIKKKKKKKKKKKKKKKJKKKKJKKKKBK;KKJKKKEKKKJKH>KHKKHKHKKKKEKJKKKKJKKKKGKKIKKGKEJKKKKKIKJGJHF$KKKKKJK>JKKIKKICKKEKKKKJKKKKKKKDJDJKDIH1<>@?JAKIJKKKKKIKJKKFJBIKKKKKK@KJGK>HKJKKKKKGKKKJHKKIFKKKKKKKJKK?KKKIHJKKKKKKIKKKKKKKKKJIJ5KIKJKKIKDHEIKJKJKKKKKKK7KIKJJKKKKKBKKGKJKKKKKKJHDHCKDKKHKKIJKJJIKKKKKKKKJJKKK-KHKJKJKKKKHKJHKDKKKKKKKFKJKKJKJKKGKKHHKJ=IJKKKAKKKKKKKEKKKEKKKKIKKKKIHKKKK3KKKKGFKFFJEKJKJFGA-KDKKJKG5KIFJKK6KKKBGEKJKIEKKKKKKKKKHKKKIKKKKKGKFICKKKIKKHKKKKKKHKKIIJKJKKACKKKKKKKHKKKKJKKKKIKKIJKJKJKKJKKKKKKKKKKKKKKKKKKKKJKKKKKJKKKKKKKKFKKJKKKKKKHKKKKKKK@KHGJKJKIKKJKK@KKEKJKKHKKJKKKKK?KKKKKKKKKKKKKGIKKKIKGKKKKKCKHJKHHKJKJIJKKKKKJJIKKKKKHKKKIKFDBGK6KKKKK3/9KKKKKHKG,JGJKKKKKAKKJKIKK-KKCKKKJKK@KKKFKKH/IIKJKKKKKKKKKKIEKKKK=KKKEAKKKKKJJKJKKKKKKKKJKKKKHKKKKKKKKJKKJKKKKKKKKKKKKKKKKKKKAKHKKKKKKBKHKKKJKKKJKKKKKKJ6KKKJKKGIKHKKKKCJKKGKKKKJK2KKKKHKKKJKKKKKCKKKBKK4KKKKKKKKGKKKKKKKGKKJKKKKKKJKHJKJKKKKKKKKKKKKHKKKKKKK@KKKJKKCKIKKIJKK @rCer/1190/29_1701_CCS ATGGGGGGGACTTGTAGTCTCCTCGTGGGCTAGTTCAAGCGGAAGGAGCAGTCCTCTGAAGCTTGAGGAGTCTCTAGAACTATGAGCCCGAGGCCTTGCCCTCTCCCAGAGCGCAGAGGCTTTGAAGGCTACCCCTGGAAGCCGCTCACCGTCGGAAGCTGCGGGGGCTGAAGCTGCGCCATCGTCACTGTAGGCGGCCATGACACCGCTCGTCTCCCGCCTGAGTCGTCTGTGGGCCATCATGAGGAAGCCACGAGCAGCCGTGGGAAGTGGTCACAGGAGGCAGGCAGCCAGCCAGGAAAAGGAGGCAGAAGCATGCTAAGAGCAACAGTCAGGCCAAGCCTTTCTGCTTGTGATGGCAGAAGATGAGGGTGGACCCGGACAGGCGGGCATATGCTGAAGTGGCCTACACTGCAGGACCTGGCCAGTGCTTCCCTGGAGGAGGTGAATCAGCTCTGGGCTGGCCTGGGGTACTATTCTCGTGGCCGGCGGCTCCAGGAGGGAGCTCGGAAGGTCGTAGAGGAGCTAGGGGGCCACATGCCACGTACAGCAGAGACCCTGCAGCAGCTCCTGCCCGGCGTGGGGCGCTACACAGCTGGGGCCATTGCCTCTATCGCCTTTGGCCAGGCAACCGGTGTGGTGGATGGCAACGTAGCACGGGTGCTGTGCCGTGTCCGAGCATATGGTGCTGATCCCAGCAGCACCCTTGTTTCCCAGCGCTCTGGGGTCTAGCCAGCAAACTGGTGGAGACCCCAGCCCGGCCAAGGAGATTTCAACCAAGCAGCCATGGAGCTAGGGGCCACAGTGTGTCACCCACAGCGCCCGACTGTGCAGCCAGTGCCCTGTGCAGAGCGCTGTGCCGGGCACGCCAGAGAGTGGAGCGGGAACAGCTCTTAGCCTCACGGAGCCTGTCGGGCAATCCTGATGTGGAGGAGTGTGCTCTCCAACACTGGACAGTGCCAGTTGTGCCTGCCTGCTTCAGAGCCTGGGACCAGGACCTGGGAGTGGTCAACTTCCCCAGAAAAGGCCAGCCGCAAGCCTCCCAGGGAGGAGAGCTCTGCTACCTGTGTTCTGGAACAGCCTGGGGCCCTTGGGCGTGCCCAAATTCTGCTGTACAGAGGCCCAACTCAGGTCTGCTGGCAGGACTGTGGGAGTTCCCCGTCCGTTACCTGGAGCCCTCAGAGAGCAGCTTCAGCGCAAGGCCCTACTGCAGGAACTACAGCGTTGGGCGGGCCCCTCCCAGCCACGCGCCTCCGGCACCTTTGGGGAGGTTGTCCACGACCTTTCTCTCACATCAAGCTGACATATTCAAGTATATGGTCTGGCCTGTGGAAGGGCAGACCCCAGTGACACCACCGTAACCAGCAGGCGCTCGCTGGCTGACCCAGGAGGAATTTCACACCGCAGCTGTTTCCACCGCCATGAAAACAGGTTTTCCGGTGTGTATCAGGGCCAACAGCCAGGGACCTGCAAGGGTTCCAAAAGGTCCCAGGTGTCCTCCTCTCCGTGCAGTCGGAAAAAAGCCCTGCATGGGCCAGCAAGTCCTGGATAATTTCTTTCGGCCTCACATCTCCACTGATGCATCCAACCTCAACAGTGCAGCCCAGTGACACTTCTGAAAGCCCCCATTCCCTGAGAATCCTGTTGTTAATAAAGTGCTTATTTTTGTAGT + /-&..-+,//7,,',33:85)58692&/-5/.3-*+0810..&-33.033953:/.38-/00/3/10,*+2036652066,$)20.&1.3-)4,,-55+3-4357:91*,10.,2)1102$*11,5&1364%.0/+$5.71%*)/,.3/0:8:9:.626398%3789726297:.442,3-265+7.*&/1*2-3.5,(9.'5*/-/)),43-5./6-60-354*)%+*%0.*-,.(521326.2(1++/&)*3:98*01'221-/-.*,))2)*02.-12.51251238'327/0/.0(43,-874:,22-40-4+.,.53./2659265242-6399:546$0.+.36834296,&3'976195-0&.5256;5.;5+-24,3631:6/(1-).81)2.017:.31%082-.)*05647/045;43/:92'''*3.252:3)+&'+1.0+-52.3368/(+-334%+))163-71524202*-%**0,233310,22/-,44314236'/+2301)--3011(),,%-0.%+*+,0/,',/01-/227.,34685:941/%.1,/1'/4.5+97012.5.455,*+/21,0/*64*16)-431:4-43-2.11')2+-94.-35437-8-2.70.('.)$$$/001))*,0&5625'3+,+-.*'+..-3((,+2-,$&'$*+++..,&2,#*$#/**)*,'-1402%0*%2...($).-(.2.11502-&)/23%,*-*(/(('"$&&)#020)'3/00.%1*.4-%&323),)//4055/041***/40.'+-/0.45/%3.&('1$&%)*-$'%3&).4#+24+/+'(+*4+-)5.1'+(3.4+0%'%#+.($'/14655,05./-)$+/(.$&+-0(1./1,*5/.4.)*//2/.*-$&#%'.'.)-/.43053)4210+0-+,1,/1141262114#)-0.,&(+0.00..-./-,*/.-/./1$(1,,../+#)(($'(()**$$+$'*$('$$),)(*-+)#&)/3(/32,/$'.'-.'52.,1/0'1.065-212,00*13/.)23-11/50-*0+,//02/,))//./0-/.(/(/)2-'0$*%"&,($#(&/)'/*-,))$%).1*0-4,).0640+,01-2*,/*/0,-(2/-+'./0,)'&*#$'$--%''%)$(0*$1.4'0445($#'$/4/0556-51,2+-030+*/)%31/0/(.00*(.3.+24.3-31'##'+04.-+130(&02.02*)/&'$%-./)("$%*-+(,23+1/+'#(,)/,0&125/-2.'.0&)'###()(*11,$+...1+0,(("&,+-1/)/-%,'.*2.1*011-.4.554++.)$&1**/-,$&*-'+0231$0,)&-2*+0,+0-(.-.(/+$-+1+-&)+('&*'$%*+,011+*1))*(%2--+%#%-#&$*$,-*$1$%).-,02,11316*+--(.0+,*)0552,11(./*3136,.*553).-.50,,2*11(-%$)*'#&+//)-03+02.$-,++,3($%)(/'+$*,-*4/,-4,-000/323,+*13+.3020..64/-031./-'.40501+0/'*+)*15+.)*)050.1+1,(&,-30/2./0,130$,,,/255/0-1054.+20/10/111)23)/364*2110-0/5(-551/320// @rCer/1191/25_1619_CCS ATGGGAGTCTCTGCGCAGCTAAGCCCGCCTGTCCACGCGCGCACCGCTCCGAGGGCCAGCGCCACCCGCTCAGCAGCCGGCACCATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAGTTTTGGGAGGTCATCAGTGATGAGCATGGGATCGACCCACAGGCAGTTACCATGGAGACAGTGACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAATAAATACGTACCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCCGTCAGGTCTGACCCTTCGGCCAGATCTTCAGGCCAGACAACTTCGTGTTTGGCCAGAGCGGAGCTGGGAATAACTGGGCCAAGGGCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGACGTGGTGAGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGGGCGGCACCGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCAGACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCAAGGTGTCAGACACGGTGGTGGAGCCCTACAACGCCACCTCTCTGTCCACCAGCTGGTGGAAAACACAGATGAAACCTACTCATTGATAACGAGGCCCTGTACGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCACCATGAGCGGGGTCACACTGCCTGCGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTCCCGCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCTCACCACCGGGCAGCCAGCAGTACGCGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATGGCCGCCTGCGACCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTACTTCGTGGAGTGGATCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCGGAGCAGTTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCTGAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAGGGGGAGTTCGAGGAGGAGGAGGGCGAGGACGAGGCTTAAGAACTTCTGAAATCAATTGTGCATCCTTAGTGAACTTCTATTGTCCTCAAGCATGGTCTTTCTACTTGTAAACTATGGTGCTCAGTTTTGCCTCTGTTAGAAAAATTCACACTGTTGATGTAATGATGTGGAACTCCTCTAAAATTACAGTATTGTCTGTGAAGGTATCTATACTAATAAAAAAGCATGTG + ./%22-+1254512115,55255.66316222-.03/+/24-.1633//144/66563664013/35135510,00.3&..434255653..5441015531).+/4144456464.113065463,556630*&+,+%,,4113600-65511+0010'1554103+512/131$2-.55+4041.635611/54/3565/514055526525.004546-35560/10,231506542361+1./121.615565-00425602(34,651465.4/0/3021//50165,501-4/-)4/5525145116,-+$1.43-40*6/64.351-0/0464/5141.44.05/25366/4.614532&23153.1446//401(33020/-0/(/)+$(+,.*-&-))+'-'&$))&-/-/,)'*)1///00.,0-+'/001*112-200.-00,/'00100/*0/0-11-21.22002-20,0-0.-00001,.10%)//-+%+0-+/+220+.%+)(/.01)++22,*-0+,0-011020(,02+21/2111.+#.05+3250.030/3&/-)*.&,).(&)++1/.%//.//&4%*,33.52512503-,).10'./2252455+55.36/$0-4*2/040/00201/1455,/./22,)+013/5.62,2,-))&-/010-04545/61663.240-041451451613324/2631./0*010**.%033/1/4)2,144/&10//6/04255363455)1(,&/4610-00456*1+%)'/5/00/2-,'/'0/**0)335).5562&.143+4/-4664112445514/0.6554-44-)44,6(0,-315652511.//)0///3%3.,33354005*54.32-.-$0%23245,,*.//,()&&-.023232.+60/'.45565425*/002-3425)/41-,'()3422,/14.141/3+././-,10/%')./.)/)$((/*01+-/-213465,6.*306465-446+52616500/,1%0/*3-5/4014.-5253/03,.'44522)2050302551005/&.0,-5554555-1.55154/1'314+5536515513+(0/16562/2656552444-%,01$11*1212+155043+0554/5/4/26,55525*11)4444541+2064//03*/*45.2/612224*25/0111620525,36*21%326664*502341/126)3.1162246455036-(+*)%1113/5//.1365441231-/4)26544/50-416454(45*20.11566611354504503215145612444121*1)/4,31,2555*/./65)+25&34434/15545564160.45366452563625,4-12240.2166655562,)(4/6515+(/,626.51224/2665523/0+3--'02-,0165246551441622-424055262453653+405.,65655154.'5544030121542-546414/6646553,3(0&104530'2/33230655526513,145.5*3/.--./*20..51&020/3412233/ @rCer/1194/24_1851_CCS TGGGGCATTTTGTCCCAGTCAGTCGGAGCTGCGGCTGCAGAGTAACGCCTGCGGAGAAACTGCAAAGATCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCTCGGCGGCCGGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCTCTAACACTCATCTTCAGAAGACGGGACTGCTGAGATGTCCTCTATTCTTTGAAGAGCGTATTCTTGAGCTGATATCTCTGTTGACCTTGAGAAGAACTGGCGTGTCTAAGTATTGGTGATGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAAGAATGGTAGAGTTTTCTCAGGCTTAAGGTATGTCCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATTGATAACTGATTAAGGAAGGAGATTAGTGAAGAGGCAGGAGCCATTGTGGACGTTCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGTCCAATTGGTTCAAGACCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTACATTCCTCGAATTTCAGTGGCGGGAACCAATGCAGACTGGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGGTCGTGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATTCTGATGAAAAGAAGAAGCTGTACTGTACTATGTTGCTATTGGTCAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCTCGGATGCTGCCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGGAGAGTATTTGAGACAATGGAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGCAGATGTCTCTGTTGCTGCGCCGTCCCCCTGGTCGTGAAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATTGTTGGAGAGAGCAGCAAAATGAACGATGCTTTTGGTGTGGCTCCTTGACTCTTTGCCAGTCATAGAAACACAGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTTCCATCACTGACGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCATTAACGTTGGTCTGTCTGTGTCTCGTGTCGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGAATTGGCTCAGTAGTCGGAGGTTGCTGCTTTTGCCCAGTTTGGTTCTGACTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGCAGTATTCTCCCATGGCTATTGAGAACAAGTGGCTGTTATCTATGCGGGTGTAAGGGCTATCTTGATAAACTGGAGCCCAGCAGATACAAAGTTTGAGAATGCTTTCTTGTTCTCATGTTTATCAGCCAGCACCAAGCCCTGTTGGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAACAATGCAAAGCTGAAAGAGATTGTAACAAAGTTTTGGCTGGATTTGAAGCCTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAAATTAGTTCCATTTGTAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAAATAAAGGTTCCATAATGT + +,*..,(%++)(++-*,(*-+++$'(%#('('')-)''&*+%++,*)(*---+,+')..-,--+.-*(*#*--)---+,(+&$'&+*--(,%),+')+--(*))--*#&&)')'$*)-'+),&()*)'&++*+,,-(+(-,%))$'(*,,$,,)-+-*-&(,$%$'+-')**.-*'#)**)-,*,'*(''(,*(*())'&"'($&&)(#$&$%&(&"'&$'(')$$'&'()(#'(%(&%(((&%'($((&%('(%())(&%%%)$'&%$%&##%'(()%))(%&&(&)()&)$&%'$(%"%'(&$%%#!#$$$$'$'%&'('%(#$$$&(&(((%''#((%())('#"#%'$((('%'(')'###(%)$%#&($&&&%##($#&()&)'()((%&))(#'&)((%'%&$#$(()))-&-*#(+&&#$*,-)(,*-,.(-()),*($+(),((&+,,#),,-)&)())-*,-(+)($)&)$))-,,-,-%+,$),,&+'%)+,,,)*)-*--*))+*-&)&&$'+,(*)---+%)'+'#&$%)')&+$()'#&+(%#+*,---,(,*'+())(,,'()(&,(*,(*)($,&,,.,-)+*+.,*+)(&))''&+-(*(,()-,+,-,$'')(*.#$++%,,()+,-+$)#)+.,&)*+-%((,*+$&#((,+*,(&+((,,,-*,"#%%(()*)-&+--*-,&'(*,*,'.-+(%&'(++(&'&))-)&(*-)+-&,+.)'&'(,(&,*(+))+,()-,%(%*+',)&,*+)'++&()(*'--,(*)'#*(%)-.++,,,.*+)'#)&(*'',&+,'&'')(&)-,+*.+-),'+*+((+(*)----)*-----,',++-*,*%%#(,*-(*)+(()-,,--'+-,',)(,(**'*---'(('''*.----,)(&'))++.-.-,,++(+**(+,*-,*%((-+'&''#*)#+'+(+.-)+#(-,&(++)--++--,(*(-*,&--+(*-+&&(&**+-,.,,((--+(+*'-'#()-*)*,(%(+&,()+&,)',+**,'*-*)-)&**+'+((%'$"%*-)((*(('&,),-(,--.-)(+,),.-),)-,),)+*%'())--+#'-,*)('--*(+*-)-,()('#'#*,)(-,,-,*$"%('+-.,--+(-,(%+)*--*$$(%(()-,,-)+*--+'+()(&,+.-*--(,)---'$+*'--,*),,())'-+,--,(*+--,-'&&%'&''%(%''$))''',--)-,+&)-,+*-(+'%()*-,,')((&*()&'(''+,*'')**)*(',*(+'++&,+&)*%,*(*-,++)*$%%++&,(%**'&+*#'-)&+*,((#$'-'+%*(((()()#+(%#''%(*'&(-+$,+-,)*---,)*)-(,--*'$%)(+)+*,---*-))+.-,.+),,.-+,,-*)(+))+,,,)%'+.-'',-&,+((*(-(-)*$$(),-,*.(('**&)')',-)**$+--+*-*-+,,*)&)'*+(&$'&#%$'+,,,#++&+,(*()()))---+)&*-,-.-+,&+*#)((,,-+-.,')+-+*'&---,.,#)()*,))$&$%,()**-(,-)#."%,)*,*),-(--)',*,+)'(-,(((,---),,,-))((*(%&$##"$#)),(+,)&*-(--(*)##$&&'*)',+-**#-,+)+)+'))--),-))%'---,)----,.,$+(*+-'(%++),$&--+*+$'#&()*'+)%&'(((,(*($(()*-*++,*-(#()++$)*%)*).-)+**---,&&&((+--,$+----.--+),--(+..-*)'(-(),-+-*(+.-,& @rCer/1196/2739_61_CCS ATGGGGAGTGGGCCCTTGTCTCTGCTCTGGGTCAGGCGAGGCAGCCACCCATGATGAGCTCTGCAGCCTTCCGAGGTGGCCGCCTCCCATCCAGGTGTCCCGTGTGCCCAGCCTGGGTGACCTGGCCGTGGCTCTGACCGCTCCGAGTCCTGCACGAGCATGGGGGCCCCTCATACCCCTTCACGGACAGTGCTCTTTGAGCGGGAGAGGACCGGCCTGACCTACCGCGTGCCCTCGCTGCTCCCTGTGCCCCCCGGGCCCACCCTGCTGGCCTTTGTGGAGCAGCGGCTCAGCCCTGACGACTCCCATGCCCACCGCCTGGTGCTGAGGAGGGGCACGCGGGGCGGGGGCTCCGTGCGGTGGGGCGCCCTGCAGGTGCTGGGGACAGCAGCCCTGGCAGAGCACCGGTCCATGAACCCCTGCCCCGTGCACGACACTGGCACAGGCACCGTCTTCCTCTTCTTCATCGCGGTGCTGGGCCACACGCCCGAGGCCGTGCAGATCGCCACGGAAGGAACGCCGCACGCCTCTGCTACGTGGCCAGCCGTGACGCCGGCCTCTCGTGGGGCAGCGCCCGGGACCTCACCGAGGAGGCCATTGGTGGTGCCGTGCAGGACTGGGCCACGTTCGCCGTGGGTCCCGGCCACGGCGTGCAGCTGCCCTCAGGCCGCCTGCTGGTGCCCGCCTACACCTACCGCGTGGACCGCCGAGAGTGTTTTGGCAAGATCTGCCGGACCAGCCCCCACTCCTTCGCCTTCTACAGCGATGACCACGGCCGCACCTGGCGCTGTGGAGGCCTCGTGCCCAACCTGCGCTCGGGCGAGTGCCAGCTGGCAGCAGTGGATGGTGGACAGGCCGGCAGCTTTCCTCTACTGCAATGCCCGGAGCACCCTGGGCAGCCGCGTGCAGGCACTCAGCACTGACGAGGGCACCTCCTTCCTGCCCGCAGAGCGTGTGGCTTCCCTGCCCGAGACCGCCTGGGCTGCCAGGGCAGCATCGTGGGCTTCCCAGCCCCCGCCCCCAGCAGGCCACGGGATGACGGTTGGTCAGTTGGCCCCGGGAGTCCCCTTCACCCTCCACGCCTTGGTCCTGGAGTCCATGAACCCCCAGAGGAGGCTGCCGGAGACCCCCATGGAGCCCAGGTGCCTGGTGGGCCCTGCAGCCATCTGCAGCCTCAGGGGGATGGCCCCAGGCCTGGGGTCAGTGGGGATGTGGGGTCCTGGACCCTAGCGCCTCCCCATGCCCTTTGCTGCCCCACCCAGAGCCCCACGTGGCTGCTGTACTCCCACCCAGTGGGGCGCAAGGCTCGGCTGCACATGGGTATCCGGCTGAGCCAGGCCCCGCTGGACCCGCACAGCTGGACCAGAGCCCTGGGTGATCTACGAGGGCCCCAGCGGCTACTCCGACCTGGCGTCCGTCGGCCGGCCCCTGAGGGGGGCCTGGTTTTTGCCTGCCTGTACGAGAGTGGGGCCAGGACCTCCTATGATGAGATTTCCTTTTGCACATTCTCCCTACGTGAGGTCCTGGAGAACGTGCCCACCAGCCCCGAGCCGCCCAACCTTGGGGACAAGCCTCGGGGGTGCTGCTGGCCCTCCTGACAGGCCTTCTGGCCGTGCCCATGCCCCTTGGGTGCCCGGGGCAGAGGGTGGAATATGCTGGGGTGCCCCAGGATGGATGTGGGGGGCTCTTAGTGCAGAATCCTGTGGATTAGAAGCAAGTTTCTCCTCAGAGTTCTCAAAGCAGGGGTTGCTCTTCGAGAAGGGGAACAGCGGCTGGGAGTGAGCAGGGCAGGGTAGGGGCAGGAAGTGGGCCCTGGGCGACCCCCCACAGCTCCCTCCCGAGGCTGCAGGTCAGGCACAGGACTGCAGGTAGCCCAGGGTGTTGTGGGTGGCAGCACTTGCTTGCTGGCTGCTTTCTGGCTCGAAATAAAGGAATCGTGCTTGTGTCGGGGTAGACGTTTCTTTGCTTTTCAGGTTCCAGCCCTGGGGAAGGGAGCTCTGCTCTAACCCGCTTCTCTGACCCTCATCCCAAAATCTCATTGCCTTGGCAAAGCTCTGCTTCTAAACATCCCGGGGCCAGCAGAGGGAGGGCAGGAGGGAGGAAGCGGCTTCCACCCTTGGCCTCCTGTGCGGTGATTTGCAAGTGGTCTGCCGCACTCTCTGAACTTCCTACCAGAGGAGTAGGAGGTAGGGCCTCTCCCCGCAGAGCTGGACACCAGGAGGGGGTCACCTTCCAGGACCAGCCCTGTGTCCCGCTCCCCTGACCCCACCCTGCAGAGGGCTTGGGCTCCACTGGGGCTGTTTCCCCAGGGGAAGTTCCTTTTTATTTATTCTCCTTTTAAAGTCTTAAATTTCTGATGACAAAAGCAATATGTGCTTACTGTAGAAAATCTGGAAAATGAGCCGGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGTCGAGGCAGGTGGATCACCTGAGGTCAGGAATTCGAGACCAGCTTGGCCAACGTGGTGAAATCTCGTCTCTACTAAAAATACAAAAATTAGCTGGGGCATCGTGGTGGGCACCTGTAATCTCAGCTACTTGGGGAGGCTGAGGCAGGAGAATCACTTTAACCTAGGAGGCGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTC + 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@rCer/1199/2763_55_CCS ATGGGGAGAAGCTGTCCTCTTCAACTCAACATGGTGGCCTGCCGGGGCAATTGGCATCCTCAGCCGCTTCTCTGCCTTCAGGATCCTCCGCTCCCGAGGTTATATATGCCGCAATTTTACAGGATCTTCTGCTTTGCTGACCAGAACCCATATTAAACTATGGAGTCAAAGGGGATGTGGCAGTTGTTCGAATTAACTCTCCCAATTCAAAGGTAAATACACTAAGTAAAGAGCTGCATTCAGAATTCACAGAAGTTATGAATGAAATCTGGGCTAGTGATCAAATCAGAAGTGCCGTCCTTATCTCATCAAAGCCAGGCTGCTTTATTGCAGGTGCTGATATCAACATGTTATCCGCTTGCAAGACCCTTCAAGAAGTAACACAGCTCTCACAAGAAGCACAGAGAATATTAGAGAAACTTGAAAAGTCCCCAAAGCCTGTTGTGGCTGCCATCAATGGATCCTGCCTGGGAGGGAGGACTTGAGCTTGCCATTTCATGCCAATACAGAATAGCAACAAAAGACAGAAAAACAGTATTAGGTGTCCCTGAAGTCTTGCTGGGGGCCTTACCAGGAGCAGGAGGCACACAAAGGCTGCCCAAAATGGTGGGTGTGCCTGCTGCCTTGGACATGATGCTGACTCGGTAGAAACATTCGTTGCAGACAGGGCAAAGAAAATGGGATTGGTTGACCAATTAGTGGAACCCCTGGGACCAGGACTAAAACCTCCAGAGGAACGGACAATGGAATACCTAGAAGAGGTTGCAATTACTTTTGCCAAAGGACTAGCTGATAAGAAGATTTCTCCAAAGAGAAACAAGGGATTGGTGGAGAAATTGACAGCGTATGCCATGACTATTCCATTTGTCAGGCAACAGGTTTACAAAAAAGTGGAAGAAAAAGTGCGAAAGCAGACTAAAGGCCTATATCCTGCACCTCTGAAAATAATTGATGTGGTAAAGACTGGAATTGAGCAAGGGAGTGATGCTGGTTATCTCTCTGAATCTCAGAAATTTGGAGAGCTTGTAATGACACAAAGAATCAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAACATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTAGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGGGCTAGACGAGGACAGCAACAAGTGTTCAAAGGATTAAATGACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGCAGCTTGATTACCAAGGTTTGAAAAGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCTCTCCAATCAGTGAAATTGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATCGGCATGCACTACTTCTCTCCTGTGGACAAGATGCAGCTGCTGGAGATTATCACGACTGAGAAAACTTCCAGAGACACCAGTGCTTCAGCTGTAGCAGTCGGTCTCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATTACTACCAGGTGCCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACAAGTTTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGCGTGGATGTAGCAAAACATGTGGCGGAAGATCTGGGCAAAGTCTTTGGGAGCGGTTTGGAGGCGGAAACCCAGAACTGCTGACACAGGATGGTGTCCAAGGGCTTCCTAGGTCGCAAGTTCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAAGTCTCCTCAGATGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGCTGCAAGAGGGATCTTGGCCACACCTGCGGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTTGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCCCAGACGATAGTGAGACCGGCTCAAGAAGTATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGCCCCAACAAGAAGTTCTACCAGTGAGCAGGCCTCACGCCTTGCTCAGTCAGTGCACCAACTCCAGCTGCTGGCAGTGCGGGTTCTCCAACAGAGTGGTCTAGATTTATCAGAGTAACGAGAAGGAAGACAAACTCCGGCACTGGGTTGCTCCCTGATCAAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTGTGAATTAGTTTGCACTTCTGTTGCAAGCTAGAGCCCACTGTGCTCATTGTATAAGCCCTGAGGCCTAGAGTGGCAGCCAGGAGCCATCTGGAGCCACCTCTCTGCCTGTTCCTCCCAAGAGGCCAGGGTGGCCAGGGGTGGTGAGTGGTGAGGGTAATTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGT 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@rCer/1200/0_2379_CCS AATAAAGAAAGGAAAAAATAAAAATTAGAAAAGAAAAAAAGAGAGAGATAAGCAGTGGTATCAACGCAGAGTACATGGGGATGGGGGCGGCTGGCACCACCATTGTGAATTGCCTGGCAAATTGGTGCCCTCCTGGGGCTGGAGGGGTCTGGGCTCCTAGCGTCATCCTGCTCTCTCCCCTAGAAATGTGTCTTCAGTCTGCCAGCTCTTCTGCTCTACTTCCAGTGCCGCATCCTGCACTCAAGCCCAGGGCTGCTGGCGAGTCTGTGGGGAGGAGTGCGGATCAGGCTCCGCCTCAGCCTCAGCCTCAGCCTCCTCTATGATCCTGTCTCCTGGCGGTTCACAGGTGCCCATCCCCCCGTTAACATTTCACAGTTCCTGGCTTTCCAAAGGCACCAGCTCATATGGCATAACCACCTCAACCCTAATCCTTCCCAAAAATATCCTGATTTAAACTTGGGCAGATTTTAGTCTGATTCTTGAAAACTCTACATTTCCTTTTTGCAGAAGGCACCGATTAAAACTGAAATGATAAAATAATTAGTATGAGGTACTTTGCTCCCAGTTAGATTCCTTCTTCCCTGAGAACTCCAGGCTAGGCGAGAGAGGGAGAGAGAAAGAGGAGAGAGAGAAAGAGAGAAAGGAAGGCAGAGAGAGAGAGGAAGACAGAGAGAAAGAGAAAGGGACAGAGAGAGAGAGAGGAAGACAGAGAGAGAGAGTACATGAGCCAGGATCCCTGGGGAATTTGAAGTCAGTGTGACCAGGATTCTGTGGCTCTGGGGTCAGAGCTGGGACACAGGACCCAGCAGGATGGCCACCTGTTTTGGCCCTTTGTTTTGGAAGCAGCTCTGGGTCCAGGCAGCAAGCAGGTAGGAAGATCGGGGCTTTGACTGACGATGCACGCATGAGATGCCGATGGTGTACAGTGAGAGGTTGTGAACACAACAACCTGGAGCTGTCGTTTGGTGTGTGGACTGTGTGTAGATGCGGTTCTGTTTAGTGGCGAGACAACGTATGTTTCAGTACTGCTTTCACAGCAACTGTGTGATGCATATGCACTTCTATACTAGTGGTTTTCTTCAGTTTTGTCCGTCCAGTTAAGTTGGAGAAAGAACCAAGTTGTGTTGTTCTCGGGAGCGGGTGCCGCTGCCTCTCCTTGAGTAGTTCTGTGACCCCCCCAGTCCAGCTGTTTTCTAGAGAGTTCTTCTAGCTTCTGGTATGCCTGCCCTCCAGCAGCTGGAGACAGATCTTCCCGCCTGACCAAAGCTCCTGTTTCTTGCGTGGCATGTTTGTTCTTCCCGATCCGGCGGCTGTCGTGACCGAGGGCCTGCCTGCCACCCTCCTGTATCATTTGCCCTGTTAGGTTCAGGGTGTGTCCTTAGCCCAGGACCTGCTCTTCCAGCGTCGTGGGTTTTTTCCAAAAGAGTTCAACGGCTCCCTTGAGCTCCGTAAACTATTTCTTTTTTAAAAAAACAGACTCCTTTCACACCATGGGATGAATGGTCCTCTTGTCTGGGTGCTGGGTTACAGCAAACAAATGTGTTTGAATCCCGGTATTTCCAGAGTTTTCCGGCGGTGGGCTCTCTGGAAGACATGAGGCTGGGAGTTCACGGTTTTTAAACTGGATTTTTACCCCTTTGGGACCCATTCCTGTGTCCTGGAGTCTTTCATGAGGCACATGGGTCCCCTGCATCCTCACACTCCCCCCTAGCCCAGGCTGCAGCCCCGGGAGGGTGCCCTGACCCCGCTTAATCAACCACCTTTCCACCGAATCCCATCTGGGGGGGGTTTGGGTGCCAAGTGCCCTGGAAACCTATTGTAAACATTCCCTCCTTCCTTTCCTTCCGGGCTGGGGGAACCTTCTTAAAAATCATAGTTAGGGTGAAGTCCAAGCACTGAGGCCTGACCTGGGCTCTGCTCTCCTTGTTTGAGAAACTAACAGGCAGTTGGGAAGGAAAATCCTGAATTTGACTCCACCCTCTTTAGGGCAAAGGAGAAGCAGGTGACCCAAGGAGGGGCAGGGCAGAGGAGGTGACTCCTGCACAGGGACCCCCACCCTCGGACCCCGCTGTCCTTTTCTATTTGTTTACTTGGCGGTGGCAGCCAGTCTGACCCTGTCTGTGGTCTGACTGTTCCTAAGTGTGTAACTTTCAGTATTATCTGTGACAGACGGCTCTGTGGTGAAAAAGGTTTATTATATTCCTTATGGCTGCCTTGTACAAAAATCCGTTAGAAAACGCTAATGTAAGATATCAGATTTCTAACAGACAAAAAACAGCGTTATGGAGTTAAAAGATTTTTACAACTGGTCTTGATTTTTGATGTGAGCTGGTTTTAGCTCTCAAATGTTGTCACTTAAATAAAAACCTTATTTGCCTT 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@rCer/1204/21_1573_CCS ATGGGCCTCGCGGGCTGGAGCAAAGAGCTGCGGGAGCTGAGCGCAGAAGTAGAGCAGGCTGGAAGCGGATCCGGGCGCCGCCAGGTTCTGTGGACAATCACAATGGGAATCCAAGGAGGGTCTGTCCTGTTCGGGCTGCTGCTTGTCCTGGCTGTCTCTGCCATTCAGGTCATAGCTGCAGTGCTACAACTGTCCTAACCCAACTACTGACTGCAAACAGCATCAATGTTCATCTGGTTTTGATACGTGTCTCATTGCCAGAGCTGGTTACAAGTATATAACCAGTGTTGGAAGTTTGCGAATTGCAATTACAATGACATTTCAACCCTCTGAAGGAAAGCGAGCTACGGTATTCTGCTGCAAGAAGGACCTGTGTAACTTTAACGACAGCTTGAAAATGGTGGACATCCTTATCAGAGAAAACAGTGTTCTGCTGGTGACCCCACTTTGGCAGCAGCCTGGTGCCTTCATCCCTAAGTCAACACCAGGAGAGCTTCCCATACTCCCGTTCCTGCGTAGTCCCTTTCCCTTGCTGCTGCATTCTAAAGGTTTGATATTTTCCAACCGGATCTTGTTGGGAAAGAATAAAATTGACTTGAGCAACTGGCTAAGATAGAGGGGCTCTGGGAGACTTCGAAGACCAGTCCTGTTTGCAGGGAAGCCCCACTTGAAGAAGAAGTTTAAGAGTGAGTAGGTGTGACTTGAGCTAGATTGCATGCTTCTTCCTTGCTCTTGGGAGGACCAGCTTTGCAGTGACAGCTTGAGTGGGTTCTCTGCAACCTCAGATTATTTTCCTCTGGCTCCTTGGATGTAGTCAGTTAGCATCATTAGTACATCTTGGAGGACTGGCAGGAGTGTGTGAGCATCCTCTCTCACATGAACGCTTTCGTAAACTTCAGGGCTCCGTGTTGCCATGGAGGCATGCCAAATGTTCCATATGTGGGTGTCAGTCAGGGGCAACAAGATCCCTAATGCAGAGCTAGAGGACTTCTGGAAGGGAAGTGGGTAAGTGTTCAGATGGCAGGGCATGAAAACTTAAGGGAGATACAAGTGGCTGAAGTCGAGTTTTCCTCTATCTTTAAATTTTTATGGCTTTGTTATCTTTCACTGGAAAGTATAATAGCATACATTAATGGTGTGTTAAAGCTATTTCCTCTCCTTTTTTTTTTAATTGGAATGGTGGGATATCTTGGATTTACCACACACAGTTACAGATGAACACTCCGTACATGTGACTAGCAGTATTAGTGTGCTTATTTTAATGTTACTGGTAGGAAGGCTGTTCAGGTAGTGTGTATACAGTATGATGCAATGGGAACAACCTTGTGGTACAGTTTGAGACTTCCAGAGGTCATCCTTATAACAACAGATGTGCGGGTTGTTTTACGTCTGCATCCAGCCTTCTGTTAACTCCTAGCTGACTCAGCATAGATTATATAAATACCTTTGTAAGGGCTATTAGCACAGTCACACATGTTTGAGGCTTCAGAAGCTCTTCTAAAAACTTTTTCCTTTTCCTGTGTATTCTAGTGAATAAAGCTCAAGATTCAGT + 2.&10+33,1604582+4387%722*628:9.:835<876,/19+1*8;85/0/5&1:(3247<56177;)=,44678:818/(38:0+01-951%389657:8);:9?.6=09:?2/6-*16657;74-40-60(241078*32.2;76?91654%.293941=782=;2143-++-401/38747/7141348438%32507:;35;,8996&4;//0$#06((%(+788,*3'2%434<02-416/1-1783<8+0+'/57)&1):;<(746;:14+8,5,7:;0<2=*:4&3*1153<.=;67=288:-8467916?=75=1><52$7&9,7.988:8:;8501/761#257::0;9491+5094596454&*88,73.711$4679496+4981/5,%51,106;-:+461,-,$+20(-.'228476/.36513'23//1&4$+15(/22/+,''2.-00033482692+3*69/531/6,-55)311*')&/%1501&1/00925--060%1*&23'54$0/19*//643/0*&754027+6.696'2.'775/5297;1:38329./:199*7842:2'8950;817,91+77&'%529&7.:967,1&,<<;,%1/):;53186?>80<798=752.;331:=8984:<.:1%98:;;2?543$+3:286(99,85(388'*45'5)0534<2=5567.89=7=578602/=6'7(4-93/5..<-=>7';/49757&;87:83;7/+05(,;5-/-+<<090,*)15.4+<:<7::6<4%=68071283>23-=;=5=8965419;=21;99:24<54=<1445266(>0=3)3582$8667?8552/54/5<HG&GJFKKCGDIJKKHKEKKKJGIIGKJKKFJKKHK:@=EKKKIJ5IKGKDGKKIKJKKJ5JIKKKK2KKKKAKKFJKJEJFKJFKKJKKKDKKEJKKKK>KK4KKJIKJJ>JGHGJGKC>JHFKJKIIKKBKJIEJKDJHKKHHJDI>JJKCHIDC4F3?D>KKKKK>KKK0DFKKBJJKJKCJIJKFDIKKFKEJ:KKFKKK>KE=KJHKJJJC7IEJHK6JFJKKKKKKKKKIKKIK9JHK3KGJH1KKKK&CKKBKKKKK-J5JJGIGHKJIKKCKFJKIKKJ?IJJKKKIJJJKHJF@HJKKKGIGGCFBJIKIKH2EJ4KK6KHKKKJJIK?GKKHKKIKJJKIGKKDJ=GHK:KKDIJJKHKKKKIKKKKIKAKFJHDECBHKDKFKJKJKK>JFJIJGJJKKKEJFJJKJFIK0HHHJCBJHKAJKKJKKKKGJKEC/F:HK/JKKJKHIIJJ2KIJFEKKAFKA?;FFFCJG8KJGDFEKHJK4GKCKKKKFKJKIKHKHKJHKKHKEKB9BFJJJ?HFG.>IKIJI6KGKIHAKEKAHGIKK?K@JKKKJKFKJK5KHJHKIIJKKIIIH7KAKJGIIJGHHKKKK:KKHIKFKJKKKK?JGHKJKKI:FC=69?-6CC59?9:49<;>:976/95:7=885598-1A@:45=:96@>8588;B>4@?@>:;1@?>39:;726694<4.239=9C?5<>19?:6D:A>8952==9;><=>??1-7<1=>A?@C@::85?::=)C4:9:A27>>4>2=?D;AA=>B>>E@DCF9DCG=<<@<78C';:65A;:=ED>>;4@=DG>@9>D8F@@;AB,B;AEF?=@:8A>;A;C7D:DA@>>=9EA8:(;D79<@BA@1<<1A6?@EC?D87::2B<<>::D@@7:G;@>@;@3;?A:;===A@04>89=B??5BC@@@1=76=:?=68@0CC>B@6:B@C@5>A7>6>2>:>9=-9+6;7?8;&BA>A@;@>64>>>79:BB>=1:C@ACA;?<==?6B??>?@CCCB>C?5?:A7;3=>@55841-66A:=+=76;9:6>A9#.7=CA4?@3@3CB>=<>;AA6C@7>CB=@>=B;B;8A4-=<=<<=A?B5@C=?@BA;:@6:CC;C>@>@>=<8A<::>;6@8;>B@A=ACC?CC;A<7:4?@@=>'19'77@:?A;>;5>A9>:BA;79:>6:8:77952@?@@89A79;97039-7;;:68;==6+2;:5404@3@A>B0AG8A:>?@62:=AAA@F?CCF@;A8EED?CBE9DEBA>>D?<>1357*=8:EAB2D9:+(F6@@8=6+55CBC799>=;D=CECAC@B0AABEA@;5AD:>B1>9>*EFA5C;??CBB<=;:>EA=B9<;BADEDE6=8ED/<>=/>69A1?B1ACEEF@E=;B$/=9@9EAEGC8DA:B:BC:BBAB>94A;>;591=8067202,3704643687/44<312;:@A7417?517AA@69:@>4:A9A@=:AAB>B:?8;C>==A@)AA<->96:8;@919'>A>B>?9@5B;;<4=45>362;<78>8>498986567?B=AB9>>;;--<6?;6,?:8;-;@A?3=92>3067;9512AB<),350/)4-31:64>7<4375=2<>5:727>>A191:9:?=?:16>*@@?670<<37>>8<2?BCC:==>' @rCer/1209/23_2413_CCS ATGGGAGTGGCGGTGGCTGCGGCGACGGCGGCCGCGTCGGCGTCAGGGTTGGGGTCGGTAAGAGGCGCGGCGATGTTGCAGCTGCGGGACTCGGTGGACTCTGCCAGCACTAGCCCCACGGCGGTGCTGGCGGCCGGCGAGGAGGTGGGGGCAGGCGGCGGCCCGGGCGGGGGGCGGCCGGGGACGGGGACGCCGCTGCGCCAGACACTCTGGCCTCTCAGCATCCACGACCCCACGCGCCGCGCCCGCGTCAAGGAGTGACTTCGTGTTCCGGCCCGGCAGCATCGAGCAGGCCGTGGAGGAGATCCGCGTGGTGGTGCGGCCCGTGGAGGACGGCGAGATCCAGGGAGTGTGGCTGCTGACCGAGGTGGATCACTGGAACAATGAGAAGGAGCGGCTGGTGCTGGTCACGGAAGCAGTCACTGCTTATCTGTAAATACGACTTCATCAGTCTCCAGTGCCAGCAGGTGGTCCGGATAGCGCTCAACGCAGTAGATACCATTTCCTACGGAGAATTCCAGTTTCCCCCGAAATCGCTCAACAAGCGAGAAGGTTTTGGGATTCGAATTCAGTGGGACAAGCAAAGTCGTCCTTCCTTCATAAAACAGATGGAATCCCTGGTCCACCAACGTGCCCTATGCCACTTTCACAGAACACCCGATGGCTGGCGCAGATGAGAAGACAGCAGCTCTGTGCCAGTTGGAAAGCTTCAAGGCTCTGTTAATTCAAGCTGTCAAAAAAGCCCAAAAAGAAAGCCCTTTGCCAGGACAGGCGAATGGCGTGCTGATCCTGGAGCGTCCCCTGCTCATCGAGACCTACGTGGGACTCATGTCCTTCATTAACAACGAGGCTAAACTAGGCTACTCCATGACCAGGGGCAAAATAGGCTTTTAGCTGGCTGCATTCTGGGAGCTCCTCCCCGTCCCGAGAAGGCCAAGGGATGTGGGGGCTGGGGGACTGGGAGGCTTGGCAGTCTTCATGCGCCCTGCTGCCGGCTGGAAGGATGGAGGTCTTTTACCTTTAGGGATCTCAGCACCATTAGAATAGTAAAGTGAATTCTATTTAATTGGATATGGGACTCTGCTAATACAGGCTACAGACAAAAGCCAAAAGACTGTCGCGTCTCTGTGCTGCTGGTATTTCATCCTCTGTAACTTCAGTTCTGGTGTTTTCCTCGAGTATCTACTTGGCTTCTTGCGGTTTTTCCCACCCTCGCTGGCCCAGCACGCGGGGACCCACAGCGCGCCCTCAGCGCTCGCATAGGCTGCTGAAAACGGAGGCACCTGGTACCTCGAGTGCCTGCAGTTGCAAGTATGTTTACACTTGGTGTCCAGTTTTGTATTTTAAAATGTTCCATTTGTACTTCAGCTCATCTGAAATCAGCCAGCAGACCGGTTGACTAAGACCGGTCTGTACCTGTGGGCCCCTTGGTGACCCGCTGCTCTTTTGGAAATGGGTGACCTGAAGTCACACTTTATTCCACAATTAACCCAAGTTGTGTTAATACTATCAGGTCTGTTTCCCAGACCCAGAAAGCTTTACAGAAAATCATTTTAAGACAATTTATTAATTTGAGAAAGTCACCTTGACAGTTCTTTGCACACAGGTTTTACAACTCTGGATTCTGAGTTTGGATTGTATCATATTTAAAAGGGAATTGGGTAGTTTGCTTTATTGAATAATGCACTTTAAAACAAGGAACCGTGTCAGGCCAGCACAGTGACTCACGCCTGTAATCCCAGCATTTTTGGGAGACTGGAGGCAGGCAGATCGCTCTAGCTTAGAAGTTGCAGAGCAGCCTGGAGCAACACGGTGAAACCCCGTCTCTACCAAATATACAAAAAACAGCCGGGCGTGGTGGCGCGTCTGTGGTCCCAGCTACTCAGGAGGCTGAGCCAGGAGGATTGCTTGAGCCCAGGAGGCAGAGGTTGGCAGGGAGCTGAGATGGGCGCACTGACTGCATTCCAGCCCGGGCAACAGAGCGAGACTCCGTCTCTCAGATCCTTATGAAGCAGCTGATGCCTGCCTTGATTCCTCAACAGCTCCAGCATAGACTCGGGGCTTTGTCCACGTCTCGCACTAAACATGCCCGGGCTTTGATGTGCCTGGAGGATTTCCCCACAGGGACCCACGCACCTCCCCGTATCTACACAGCTTGCTCATGTGGCTGGAAGCGCTGTTGATAAGTTTCACGTGCTGGCTCGCCAGCTCTTTGTTTCTAGACTTGTAGCTTTAAGCGAACGGTGTGGTGTGGGTTGAGTGTGGCCCACCTGCGGGATGTGCAGGGCTGCCTCGGAAGCTGGCTGGGGACTCCAGCCTCTGTGTTCGTAAAGACATTTAGAAGTGGATGGATGTTTTTCCTTTTCTGAAGTTGGTATTAAAGTAGGTGC 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02,3,*142063-0510/04.++(%-31.4116///4/263445-16/-615551).11*2*%'-+.3/5/1,.41134*-4.43(,.2',10'/+---.1/01024-*03,0/1.(/0%.(-/,463.-2355546-,2224165-640.*.16,*6626356363,'+553392:3:3;;806/68547329:5588/063+$476..83:1794.6495130989.90;82213214-30.)24)4104+212,(2'+01(/4*.-3)..&076&02.2+0537:5274307298;9(78585-4:4)1-901279,,4'60+-+26-75:6756::497;:9997527.288/96566+2.57:5662386835844,+(::6155,35107;806:3&8939-/71,2%.56325138-5019515923'/74657470681.2/48338;1624795.1-25318.$.8;:/31481236;59/26334/)46:.+93&2+76/636,1*71852.21.2777889;8::9:84:42:560294929)6870361/31976146678,63351986-173692016149:16)46(71579:/48:*291:4055.467/-124741)85539&&*-53:211.53,/2/+/'0*10100+//,3/-242.426451,21-34666225142305/42.42/*3636302..102748&-0)96484(,$**../-0+8%20144-50-(4-)99501+0+177,)(12/1+//13.849,2::,3:.82583::714937:574785/63.14.-89:983633616568828,53*02989482.864894/10711352799491&3335,8484.&+1%33737:5.812967094807588873;853697:/9773105088;6438042+0%866689(6583105'-22370125896846090431$5.11249)7055:6845/858177;247:616::548.:999;;335-&.343339.201'27676+53-6:3:2430.-.586694:.53/%3+),,..353.7459:7764408.35+65849:/;:511:778086$61,0..,507:51)7025136.65:637:90369;4524:556943)13742:7:7557072.6&6658,7-',//16)978.&7216.94.,5537&-6786981.&4336+:,6-238547*9753575960645808/7245759&555.07.-32*6914443-1$*1.:868;:::7167:::;92+*+3784445.434656427-%,+(,.#,2:9+44237:9569+,.'++338481642501/645569+7:;:76*0/**04//0887'64.-5468325982:8+0,09)58323545+-+.6::8:3312;;;0-,4/36946:5/45.**2*/,1601/4$+-)+/'34,.-0/2//7,,.2.-$,)4.00,$-/'&-/7'/+21)*-2.--2)11+36033715954+667356/65556936.61844+0135.57994745743+414452,/(-/''.+0-297/99)67)&,*353/46113333-43-24/6/1446**,10+)4,-64515559+639902-%1/)1*//%-0.34-.//+2,5/05-3982-33936,76967:2/984:53.8848/56**'7:4722+565'3233.*'(311-1/-1*+0$+.*2*$,'0/-%)243'*2*+,,-'...*&''&('%%(("%'-*,#)-+/,*%,((&"(*+/)./*,+-,+35&05$$+/0,-152*//+**+34241*6)/.433244043123-4440264-4746438:2,4176/-)/,269*1//13/...0/*+)%(&',.+$&&.%,-/(217.,/($+)*((&-&$)+-2*5/.242021&/*-)&,,+'./-),,*+)%+-1.013.151./,.-/2/7.++',.*160'4703119<23792939389225859*3249;;9<:488<;(77366:9697>689/17:58969.992=3:5=:77=<6??>;=>333>=78:8>249::>886=>6>=<6<>::2:87857><:><>>:<6;<<8;:98;9=:::>80.:=?>=3<>?9?>887>;6=19:><'47<=;66=69;><6=:3<98/4;<7:58<=:9831;53<6<,;>8>8-744*-26962<64;56202=::;?4<;96932?=69=88>779486967/666,0/+$'//3266786666693>=:5457188630:5599;2=><9197711+1*7851*<89;39(0268>>0694<;1ACBCB=7@?><;8:8076=79:9B>;:?06;<3?::=?>A5<46>;BB===51<>?=95@8=8';=@>;.<.88<785:?BB.A=:';B>B??BB@A@:==48?B?7>;>B<58>;AB<9.@:49C?CACA?<<;=2=5@C9<:;C?49@5=)?2=7;:7@?9>;>>@CBA=C1>;<8@=;<78;743<3/13:?B>?=@>?<:930441+1474366578/==@'BC?BC<>A95>>A/B=BB:,71A==?A@?3B4>AC:7>@0;7><@=,:A<:=:A=9652.3?92===?:??B?17:6B<:9%9BABCB<9=8C=A1@8?=>:<:<8AA@::?>826B;5@37:.17;0:,:>77>;)61:9984?=>5=6=8<8;99116%331<'8(=84<3::;;0:6871005791A49=3@?24<@9;*7B=>;)8719042B61:9=<==&7?;<-5A6:B?>@=>>@@@=>A-?A+>;=;:18$@C?AB98@CC8@=6=B==;=B<>C?6=::+4::-36#9:9756882209>;34-938172::9357432:3-225)75,3244/+44'5214'/9837514:=>5><51<<:2)16/*=:=50:.-8<4>32&44=4=7599:24%07/3&%/537558*5287>;:2166//2)21-.267172=01;30/3&/76572246,.4/6(86-6.7771<37654214&7==:;,7700446,3<86:8961>88396<7808135==;:876*36.6;;31<)5)'=88=:.556/753==7?9:<8;<==986,,;=1*:?9271633104.30/'2,240-0243).3/2-.*)*+$.,12643-13305.5+%+0459657342237*1$(/2..4550/426-/9::07051-.:6935113246946368834/3.25514.3-13:9+6)21'549798.25-648/:4:955958:.6*3162'60068)*,+*736'365/-354&0112&%/&1&66.3+*2444&7893-5653:75/587966;934280/9':042-67/36104;99618:6:247335878288126980-5634:6*5228543(684*99707-98761540775085323778,4+581:52472(+$98.055053211103444&'/432*.913(8:3*/0/3231'7394..-:722246&+2.02/699),4/%6.-06/)53-,,0#(,/0/*111125144-302/100/).'1/10+0201--&0/-+,-)&/2/1.-&/1.-0+/*100.).-/.10,-00))&&(,(,*(+*%)%&+.(***-.(/,+1.-+-,1-0.1//).,/--*1/1111.*0.11,)-.'0111-.''*00,11.12/1.,+#$$&-'/-,),011-1-,101-.-*.%/+1//&/*0-++..,/.11-*-.1-1/200'200--(01.0.1*/0&00.111*,&/+.**112-11*)($02/-01..,1,*'(%-$,/*-2201 @rCer/1214/1187_56_CCS AATCTTCACTCCTGAAGACAAGAAGGCAATACATCAAAATGAGAAAATCACAAAAAATTTCCTATGTGTACTCCTCATCCCTCATCCTGTATATTTTCTCTTTTTTGCTATAAATTATGTTAATTACCAAATATTTAATGCCTCATCATGAGGCCATATTCTAATATTTATTGAGCTCCTGACTTTCAAGATTGCCATAGAATGTATTTTGTTTATTATAATGGTTTAGGCATATTTCATATGTGCATGTCACAGACTAATCGCACACTGTACCTTTATTATGGTGAAAGAGTTAATTGTTATTTTAGGCACATATGCCAACTTAAATTGGTCATTTACCCCTTGGGAAATGTCCTCAATCCCTCAATTGAGTTTTACTTTCCAAGTTAGGTGTTTAGTTCATTCTTCATATGTGATAGTGAAAGTAAAAGCTTTCTTGACCCTTAAGACTGACATTTTCTTCTTAGGGAAAGGACTCGATGCAAGGTAGACTACAGTATTTCCCAAAATAAAGGCACACGGAGAAAACAAATCATAGATCTAATTAAATATACTACTACAGGAATAAAGTATTGAAGATTTACTTTATTTTGAATTGATTTTAAGTATGGAATAATTGTCTTTACAGCTATAAAAAGTAATTAGGGGTGTTTACACAATGTTGGGAATTTCTGCTTTGACAAAATAGGTAAGTCCCATGGCCTTCAGAGAGGCAGGCAGCAGTAGAAACTTTCAAAAAAGTAACATTTCTCTGGATTTAATGTGGAAATAGAGAAAAATTTTAAAGAATAATTAAATCAAAAACCATGGTAAATGAAATTTGGTGATTAGATACAGTTTTGGATGTTAATGCTAGTTGAGAGAAGAGAAAAAATAGAAAGTAGAAGCAGAGAACAGGATCATTGGAAGGACCTTAGAAATCGCCGCTCATCCATTTAGCAAACTTATTAGCATAGCGTGTACATACTAGGATCTGAGTGAGAGTGTGTGACTTTAGCTTGCTTAATATATTACTACTTGTGGGATCTTTGGAGACTTATTCTCTTTGAGATCGAATTTCTTCTATAAAATGAACATAATGCTACCTTAAATGTAAGGTTACATGAAGATAAATAATAAAGGACTACAAGG + *()')%&(%'((&%)&'$(((()(($(,&&**$',-+-)()$)*-(')(,-)(,**%-+*,))*),+(('',-&*(,***&),''+()'*)'*,,)%&,)+,,+,$)$&##&-*)')%'*%,*+('+'&+'**--(*--'#$('+'*(((%%$*'+'&'&)#((,(*'%'-(,-)$%&&&&&&+,$+-(*'%#''(,+&(,'(,+(+)+&*++%'+))+$$$(',-''-'+&)(++)',,*+-+%&)*&'*#%&&))$,(#%"$'%#),,+,.*,((&&',,+&''-.,+''''%#,((+)#'*($)'$,,,+)')*)&)%**#%($++,+,')%*&)&%&#,(++(--%,(,*&(()$+..+,++$)#&'(-,-)'*)+'-)-)$+''+&)&&(#&(+')*,'(+'+)&'$+)+)%*+*),-*((,-*&,++,()+(--..-.,-(++,(,--++),)--)),,(,-)+*%%&$''*,(#)-.-,((&(+))#++%&)*,*-,,+++%+**%($&+&+#)*0..-)&//+&'.)*(.$'.12/2.-.)$$).+(***.)&(#$$('$"(/.0$&--..540.022.40*0+/-&2*5440321&/0/1610.24.0(0/.65,35043-,'.34/'+*0).(00/-(*--1'/3--0-)*&$+'(+,-.'.-',-.*,(%($$#((+())%,*(,$).,(+%*''%+,+,1+$%*'&&'''*&**)*$(*.%$#'&%'#+(+*/*-+%.,011+%%,&(*,,+,)))%+(/),-/+.&'..&.+&,*,,/+.&((&0/000/'(&,/2,-,,+11.+$20,/++)$-+**-00,/1,22/)*.1.0/-&*++)+.2-1/-)'*,/-,*--,'#--*/.)01-//,*+***-2/-0.*(.0*-&/,.*.$.+&,*),/1)')/-+)*#11333)1/%2/103$0+)*&(**%*-*(+%*,(&##*'+),,,'"&#'(,(,*++&($+-)+(++)'*-*#*,'%)-++)+&(%(+*(',)+&,,,+(,,*',#$'(+#(+-),*++,&(,(,&+)+()*%$,*'))(''$''*-('+&-),(*)+,')$*+$,--,))&,*"))(+-&+((+-('-(+,,&,)*''$&+&,+ @rCer/1215/1741_57_CCS ATGGGGAAGCTTTTTCCGAGAGGTTGAGCGGTTTGCATAATGTCGGAAATGGCCGAGTTGTCCGAGCTGTATGAAGAGAGCAGTGACCTGCAAATGGATGTGATGCCTGGCGAGGGTGACCTACCGCAGATGGAGGTAGGCAGCGGGAGCCGGGAGCTATCCCTGCGTCCCTCCCGCAACGGGGCCCCGCCACAGCTCGAGGAGGAAGGCCCAATGGAGGAGGAGGAGGCCCAGCCAATGGCGGCGCCAGAGGGGAAACGGAGCCTTGCTAACGGGCCCAACGCTGGGGAGCAGCCAGGCCAGGTGGCGGGCGCAGACTTCGAGAGCGAGGACGAGGGCGAGGAATTTGATGACTGGGAGGACGACTACGACTATCCCGAAGAGGAGCAGCTTAGTGGTGCCGGCTACAGAGTATCAGCTGCTCTTGAAGAAGCCGACAAGATGTTTCTGAGAACAAGAGAAGCAGCCCTGGATGGCGGGTTTCAGATGCATTATGAGAAGACCCCGTTTGATCAGTTAGCTTTTATCGAAGAGCTTTTTTCACTGATGGTTGTCAATCGTCTGACCGAAGAACTCGGCTGTGATGAGATTATTGATAGAGAGTAGTTACATGCTGTTAAAAGAGGAGGAAACTACTTGAGGAGGGACCCAACTTTCCGCTATCTTTTGGGTTCATTCCAAATAGTTTTGTGCCATTGAAAAACTTGACCTTCAAAAAAATTTGTTTTTCAGAATAGAAGACAATAGGACAGTGACTGCACAGTTGTGAAAAAGGAGAATCATTAAAGAAAAAGGAAAAAAGATTTTAAGACCGTTGAAATCTGTTATCAAGAATGTGCTAAAACACCTATGGCTTTGACTTTGTTATTGATCCAGATTATTTTCCTTGCATTGGGGAAAATATCTTTCATATTTGTTTGCTGTAAAGATGGTTTTGCAAGAATAAGTCATGACCAAGACAAACTGCCAATACAAGAGCCCACTGATATTAATTATATAATGAGAAAAAATGTATCCAACTAGGACACATATCTTTTGAGTTATTTGGACTGAAAGTTTAAGAAAACTTGGGAAATTCTATTTTGTGATCTAGTCAAGCCGTCGTTATCAAAGGCTAAATTTTCAGTGTAAGACAAATGAAGTATTCTTCATTATTCCAAAAGGATGAGTAAACTCAAAGATGTATCACATGTGCTCTGTATCTTAAGATGTGTTTCGAAGAGCGTCTGAAATTTTGTTTGTACATGTATCTTGATCATTTATAAAGCCACTGTGATATATAAATCAAGAAAATTCATTGTCATAACCATTTTTAAAAGTCAAAAATTAAGACATCTTTAATTAAAAACTTTCAAATCTAGACACTAAATGTGTGTGAATGTACAAAGAAACCATTGCTCACGCTGTTATATACTAGAGAAATTTTGTTTTGCTTGCTGTTTTAACTTGCAAGGTGAAATACTCTAGTTGAACTTCATATTGTAAGAACTGTTAATAAAAAGTTGTCAAGTAAAAAGCCCTATATCTAAAAAGACTTTATGAACAGTTATTCTATCAACTTTTAAAGGTTTTAAACCTACCCAGAAATTACCTTGGTATCTGAAGTTTCCCTCTGTCTCCTCCTCTAATTAAGCTTGTTATTTGTTATGCACCAGCATTGGAGATAATAAAATTTCTTGTTCTG + KKKKKJDHKIKJKBJCJCKKKKKKKIKIKKKKKKCKIKIKKIKKKJKKKKKKHKKKK?KIKKCKJKKKKKKJKKJKKKKIKKHKKKIKKJKKKKJKKKEKKGKKKIKK7KKJJKKJKGKKKKJKKK4KI0KHKEJD:KFKKJKKKHKKKKKKKKKKIKKGKKKKKKGJKJIKKKKKKKKKKKJKKK;KKKKKKKKJJKKKK8KKKKKJKKGKKKKKK2KJJIJJKKJKKKKJKFFKKKKKCJKAKKJJKJKKKKKKAKKKKKKKKGKKKKIKIKHEJJEKKDKKCKKH8GKKKK;KKJ:KIKJKKIKKDKBKKKKKJKEKKKFKKDFKHKKKKK@KKJJKKKKKAKKJKBKJKJKKKK=KKKKKK-KFJKJBKEJJKKK:CKKIKKKJKKJKKKHKJKKJHKKKKKK6KKKKIKKIKKBKKKKKKKK8KGKKKKK8JKKKKJKIJKKIKKKKKKBJKKKKDIKJK3=IAJKKKKKKKK@KJKGKJJKIKKKJKKGKKKJKEKKFKKKKBGKEKJGKKK@KJKHIGKK6KKKCKKK8KJJJKKIHKKBKKHKKKKKKJKKKKIKKJKHKKK2KAKBFGCAK@KKGKKKKKKKHKKKKJ7HKKKFKKKKKKKJGIKKGKKKKKKKKKKKK@JKKDKIKJKKKKKKK4JKKJKKIKKIKIKJKGKKKKJKKKKKIKKKKKKKKFKFKJJJKKJKKKJKJKKKKAKKHKIAJKHKHIIKKKKCKKKKJJIJKKHKJKKJKJKHKKHKKKFKKKKKKK?KKKKJKKGKKJJIKKKHKKKKJKIKKKKJKHKIKGJKKKG;KK,IJKBJCJ*KCIKKKKKKJKFKKKJGKKKKKHKKKKKJGKIIGHJKJKKK:JKJKJKKKKKIKKKKIKKEKJKKKJKKKKKEKKKKK;KIKK4KKKK(EKKKKGKKKK:KKKKKGKEHKIBEKJKKKKAKKHKJKKK1KKEKJKKKK9KKKKEK>DKKKJKGJIKJKKKBIKKKKKKKKKIFJKKHKKKKKKJGKKKKKKKKKKKKJKAKKKHKKKKKKKKKJJJKGKJIIJGCFKG?@I-FE8JJBKKK @rCer/1216/0_1079_CCS TTAGTTAAGAAATGCCAAACAGCCCTTCTTATCATCGGGAAAGGTGCTGCTTATGCTCATGCAGAAGAGAGTATCCAGAAATTGGTGGAGCAATATAAACTGCCATTTTTGCCCACCCCTATGGGAAGGGTGTTGTCCCTGACAACCATCCATACTGTGTAGGTGCAGCCAGATCCAGGGCTTTGCAATTTGCTGATGTAATTGTGTTATTTGGTGCCAGACTAAATTGGAATTTTACCATTTTGGACTGCCTCCAAGATACCAGCCAGATGTGAAGTTTATCCAGGTTGAATCTGTGCAGAAGAATTGGGTAATAATTGTGAAGCCGGCTGTTACTTTACTAGGAGACATAAATGCTGTCACTAAGCAGCTTTTAGAGGAATTTGATTAAAACACCATGGCAGTATCCTCCAGAGAGCAAGTGGTGGAAAACTCTGAGAGAAAAAATGAAGAGCAATGAAGCTGCATCCAAGGAACTAGCTTCCAGAGAATCTCTGCCTATGAATTATTACACAGTATTTCTACCATGTTCAAGAGCAACTACCTAGAGACTGCTTTGTGGTAAGCGAAGGAGCAAATACTATGGACATTGACGGACTGTGCTTCAGAAACTACCTTCCTCGCCACAGGTACAACTTGCCAATCATACTCTTGGTAGTGAATAACAATGGAATTTACCAAGGTTTTGATACCGATACTTGGAAAGAAATGTTAAAATTCCAAAGATGCTGCTTTAGTGTCCCTCCAATGTGTTTGCTGCCAAATTCACATTATGAGCAAGTCATGACTGCATTTGGAGGAAAAGGGTATTTTGTAAAAAACACCAGAAGAACTCCAAAAGTCCCTGAGGCAGAGCCTAGCAGACACAGCTAAACCCTCTCTTATCAACATCATGATTGAGCCACAAGCCACACGGAAGACCCAGGATTTTCATTGGCTGACCCGCTCTAATATGTAAATAAAGACGCCAGTTGGTGGTCTTGAGTTTTCTCTTTCTTGCAAGATGAAATTTTTATTTTCCACAGCAAAATTACTCTACTGTTAAAATTGTGCAAATAAATATAAACATTTAAAATGAC + S$$#%%$&'#&&))$$&)),)(#..$+)+)&0-*.1+0.)+102*.0+,&,*/&+,)+)&$)&&'+&+***+,+*)'*,/0,0,/+#%%,002)./&+%*+/-2-%,-.-.,11/'0001/'&.-'**0001/1-1-1101-*-10,-..1'&-1..-*(+**+%..1011.1.02*'++0,1110-.&-+,&**,))')+*-)+.+-.$.*#'%(-2,/'0,*10+.*1$+)1./-#&+.-2,020111*+010,/(.-/.0-101&0111,/*10)--+'+11..,0+&#)*(',*)**'-,(+%+$&&&*21*.%+/%*+1-02.0/+1'10-$(-./,-(1.-11+)/00-0.,&/1-+-&,-/1..$+*10/33155#/-)#&()+0-/.31/2-51050++131551126551465/162-3/.563,++.2-44)66500.2263324),03054403340-505/026300+/)0,534.3)2/-+&*.4523//15461)2/1..,200$+/252-41/502((-0.'.(,***+-*,/.-33/1.&%',*--((/023'.-/)*0'*1/*0..$),13225%'-/31*+.-2-22-/(%((*$(+0+*/40/010,,++)%/4100264-5151./((+.3,3&,-1/0((.3+42605/4.5.564-1/335(41244-,10(33-216-)$//155651#-&*2-,1-4'04566631.-.3554.).)42/.1.34-11+435243/1/532645--,30,-%04.1,..'%)3.+/1-(52.13*4*468/3789+45:40%15110/1..)+2797666.-.9547*0::4751922686'73::726:7644:72065-740483/2.54)455520-.25;8343;825;6567461..5;:81:97;;70;6;;>9>:<999>49<<498746<==>97=82-:::5=556610634;1:03/0742(63/:800:9163/7.40140*4,'108:6*=:;68;8;?>4;?;884;;997=8313/85;5<6.21'290(66'/&&0091%8.-2827301 @rCer/1218/25_2178_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGGACTGTCCTGAGCAGATTTGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCACACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTCCAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGCTTAATATCATGTCTATAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + :;,@?<,57;>)?6>5C8;B5889A>@><>97?B4>02A;;C@B>:<==>@C?CBB5BA50?CB;94B8BCA?A;=B?@AA@:C>7=/=:CACB>A@>B?>9>7@@?C?C@8@A1AAA==BB;B5?A7BA:AA/A>>@@:>5>>;4::?538:@?;?=4C(:;:AB9:50>>4?=:>;=>A41:A;998>8CC8@?B-A=AAB<<9?9;A:B53;7849<<8=>565;<6>3A?738-@>=A%989?8<>4:?>;><;<5425895;;=95;0/3::05868(6786:.39:8:;28=;4:91/==>97A=2;B?:=6;B1=>1@A>?996<@@?=C7AA$9.)*+8,'&,+#2,5/6)35,';+%*,$79;:93535A'><66@9<>5<3;BB<4>5?1B;6@@=>@AB0?<:@:CA><98@>=B>A>C6>>6==;9A95A;35::>>:6==??:BAA:B4>>CB=?;9;1A><;?ABB>;6>75747;>;;;9)83;.<:6::C=A>79>A<481:>=.7560477>@:A=:=4??;<@>:@=&836/885>;A>(0.;.<&9;<:C@A7CBCCA8?7:B=?B=@=<=BC>AAC@C@C>;<37CB:AC@=.A<<<<@=:???;?>;=<>;@>9,8;<@)>A><@8=0=;43)<39=C8A+$:0>A@=9B;CBA>C=481@CCBBB/<@>A=@+;<0;<;6=66A=6@A8?655187;8>;@7B@AC?B>B@/AA=?;B>A>@=<<85>CA7=?A9(9==;?99>6576A79@?7;03:2-<:>:-:3:(778;/6808<5>8=77=C<<0AB=2;76;56090;::;7468907:<:7<9?>;9;,:?=?A>A<=>96B;4<899=8<79ACCBCB@<<;#;;73)*09=:9652<<;:?@C@=9;AB?<;@@C?A=20CACC?C>;BAA2BB<>=<:7<=>B8B;>=:;'??BA7>>>@3<8A,<=8?@*<44.06353@<>B@?;<6C@7@.?=@0008?;@2=/3;50?0??==.316<:6>>>B<0??@?3C@C=:>C??B@?=>5*53939>8<:?1A=>@;=??.=9<;>A359;A;@A+>A>+9).?<=?A?;=C==B>A>4?999<7=C@>C?B;B>B;@:=AA7;@:66?B==(>68AB>B>?@<;;989/0429::6:>;<>9<6:;><8-:?,62;22/05;1/9/874799./37::>347::<<;5<=54::8>8=*0;7>=<6=<2<;833=*96=8:8=<2?;3;;/>96>:9:9<67;8?:9;?<.4/;58;?8891369/6870/83424<:=9;3778009978=>=8=8&59;;9665/:2.0)05=9%0471=*9:9(81:=<;03:7.<>0092:;=685:55-;.=;:37+48:7:=9;>8<;:71;468<=:3;;4;*;:>7>7>7+:7:57.<79:6748558=)98:9/68>>/833-:550:59166;=5.=<5474>>99=/<;;76?;=:8:?21:0247?7>9;35'9:7=6+:>9::><;8=>>226495:&7875759:8;*:44;5=&/8;2;9585;,3=99/:7=9;>7;;7><;48144+123468422.13/;;=>89>=668<135.):64<6=623<4<>96,$'467<=1*7=5998:7=9401048%147;8:4:>97<2';<<<=;9=9<=1<>/:;40745:::;<>96>>>;9;>99:><>;11;9::=8=>807615793978596305..300053(79:77;9:;:8>6=;48:=494?:9=9?>--':<<;>3271/3=7::?97)8<6:5/8>88???83782:=;'8933;58= @rCer/1219/25_2123_CCS ATGGGGCAGCTTCTAGTAGGTTCCAGAAGGCGGCGCGTGCGGTTGGGATCGCGGAGCGGACGGATTCGATTCACGGGGTTCGGGCCGCGCTGCGCTATGGAGCAGGTCAGTGAGCTGAAAGAGAAAGGCAACAAGGCCCTGAGCGCGGGCAACATCGACGATGCCTTACAGTGCTACTCTGAAGCCATTAAGCTGGATCCCCACAACCACGTGCTGTACAGCAACCGTTCTGCTGCTATGCCAGAAAGGAGACTACCAGAAGGCTTACGAGGATGGCTGCAAAACTGTCGACCTAAAGCCTGACTGGGGCAAGGGCTATTCACGAAAGGCAGCAGCTCTAGAGTTCTTAAACCGATTAGAAGCTAAGCGAACCTATGAGGAGGGCTTAAAAACACGAGGCAAATAACCCTCAACTGAAAGAAGGTTTACAGAATATGGAGGCCAGGTTGGCAGAGAGAAAACATGAACCCTTTCAACATGCCCAATCTGTATCAGAAGTTGGAGAGTGATCCAGACAAGGACACTACTCAGTGATCCTACTACCGAGAGCTGATAGAGCAGCTGCGAAACAAGCCCTCCGACCTGGGCACGAAACTAAAGATCCCCGGATCATGACCACTCTCAGTGTCCTCTTGGGGTCGATCTGGGCAGTATGGATGGAGGAAGAGGTTGCACACCTCCCCACACCCCCTCCCAAAAAGGAGACCAAGCAGAGCCAATGGAAGAAGATCTTCCAGAGAATAAGAAGCAGGCACTGAAAGAAAAAGAGCTGGGATGATGCCTACAAGAAGAAAGACTTTGACACAGCCTTGAAGCATTACGACAAGCCAAGGAGCTGGACCCCACCAACATGACTTACATTACCAATCAAGCAGCGGGTACTTCGAAAAGGGTGACTACAATAAGTGCCGGGAGCTTTGTGAGAAGGCCATTGACGTGGGGAGAGAAAACCGAGAAGACTATCGACAGATTGCCAAAGCGTATGCTCGAATTGGCAACTCTTACTTCAAGAAGAAAATACAAGGATGCCATCCATTTCTATAACAAGTCTCTAGCAGAGCACCGAACCCAGATGTGCTCAAGAAATGTCAGCAGGCAGAGAAATCCTGAAGGAGCAAGAGCGGCTGGCTACATAAACCCCGACCTGGCTTTGGAGGAGAAGAACAAAGGCAACGAGTGTTTTCAGAAAGGGGACTATCCCTCAGGCCATGAAGCATTATACAGAAGCCATCAAAGGAACCCGAAAGATGCCAAATATACAGCACGAGCTGCCTGCTACACCAAACTCCTGGAGTTCCAGCTGGCACTCAAGGACTGTGAGGAATGTATCCAGCTGGAGCGACCTTCATCAAGGGTTATACACGGAAAGCTGCTGCCTGGAAGCGATGAAGACTACACCAAAGCCATGGATGTGTACCAGAAGGCGCTAGACCTGGACTCCAGCTGTAAGGAGGCGGCAGACGGCTACCAACGCTGTATGATGGCGCAGTAACAACCGGCATGACAGCCCCGAAGATGTGAAGCGACGAGCCATGGCCGACCCCGAGGTGCAGCAGATCATGAGTGACCCAGCCATGCGCCTTATCCTGGAACAGATGCAGAAGACCCCCAGGCACTCAGCGAACACTTAAAGAATCCTGTAATAGCACAGAAGATCCAGAAGCTGATGGATGTGGGTCTGATTGCAATTCGGTGATGACTTGTTCATCCCCCTTCCCTTCGCCCTCATGTGGAAAGAGGAGCTGGGACCGCGGCGAGCAGCACGGAGCGGAAGGGAGAGCAGGGGAGAGAAGGCCTCATCTCTCTATATTTATACATAACCCCGGGGAAGACACAGAGACTCGTACCTGCGCTGTTTGTGCCACCGCTGCCTCTGGCCCTCCCAGCACACGCATGGTCTCTCCACCGCTGCCTCGAGTTCCGTATCTCTTCCCCTGCCCCCAGTTGCTGTCTCGGCTGCTCTCCCATAGTTGGTTATTTTTTATTTGGGCAGTGGCATGTATGGGGAGGGAGGGGTTCTTCCAGCCTCAGGTCCCAGCTGTCTCACGTTGTTTATTCCGCGTCCCCTTCTCCAATAAACAAGCCAGTTGGGCGTGGT + ('#($#&&''(&'&%&(''))*)+*+',%(()'-+,*-,,%(&*$,,*,---&)'))%*'),.((-+*(&(&#((---(*##)(+--,**))+-),*--,*---,,(,,,&*,,+,'#(%&%"$))&*'$,)(((-'+),,'%+*)*--+%**'(&&'&')&*()'**&')-,+**,+*+-)(&##&(*$$"%(()+,(-,*),(-,-+(%,(,,*&&'&()&'&++(*,'&'')#$$$(*-&*)-++.-++*-,(--,'*','*,-+*,+-(+'+*),+)-*++&,&*-,%))'*),&))+))($('),,-&***(--.--+#'--*.-+))*()+-,(+*-,,,&+(,-+.*,$*"'()*(((*&,,**+.,*)-,(-+&*,+&,#(+*),---,(++)-,%)*',+*%&*)&*%*++$)),(-,('(,&++%+,++(,**((*%*),+&***)%$)(##%'*,-)--',-(&-,'&+$+*'-(,*-,$&))+#&$((%(&&&%''%$##"#)'(-*-+,(,(,,--))(',+(+,*#())+(+,+-,&*(*&+,*,),)),*+%+**%)*&,,+,.,)#&)*--,,),)*-,*)#,+(++.--+.)),,,)((-,,)+(,))--,(+)#'+*--,+())%%))*-+(*()((&(')(,',%%,+(,)+'#"%'$(&#)#(#%%$(+,)$#%(&--+(&(+,'&(#)'#&$((%*+.,)''*''(*+,,'),-*)'('*+),)(-,++(-,+*--,.-+(,+,-+-,,)','#&)*,'(,(+,)*$(,(&+()+)',-+',+*)),.*--+.-,)*,-*--'$++,.,.(+,(),,-()),-(*-,.,,-))-,*+*'(,&'-,-,+',()$+-%%#(,)%)($#&&'#'(*+)-+,,*-+-.+-+(++-*+(*%,,,*-,&+.+.+,-+.-)+*+*,*,(*,,&***,*+),(-,+*''*)+,-*-'%+,,.%*)*,-+,)--,-+(+'+(.,$,++,'++,(--'++,.-&+*##,-+.-.*)),,,)()+(--+(--)+((,(--()-*()%)),+,&++++#***,&*(+*'*-,-*&--,,'**--,),',+(*(-,$'*--)-+-&()+-+--,(++,'%$')+)%),-(---,,)++,.((---,+(,+(''(&)'&+**,+,,+,('**+-..,&,*()*---,-+*)%+++*-,-$)++)(-),)+)',*-,-)-)((%*(#))(-+,%,++$+**,,,(-(,)'+*,*)*$#"$'%'$%$)+--,---+-&,+(+,.,)-((&-)-,--,(,)+,--(,&+)-*-+--)-*.)+-,)+-(,,),.-,%,(,-'++(++)-))((,*(++-1.-+./.0$'+/*%10.2).,,.&+((*'&.),-))*$++,,10&,0/*)**++-.+'*-,10-*,10112,12/+(+/011+11/2+-,+11.21/1/*-.+01,1)/,0+,.+)/1'((1,0101)%..*000'11/+--+/--201,&))'***0(0-,0-011,-2/001,1.1-,,01,*/00/-1-/1,.0&+--,0+/,/0.)+0-001112121,-20'0-0-011.,.-)++$))*)**-*',(+-1.111,0.---.-120(0/12-0/*0/00111-.02.&/-211120)/1/1120110,010111.$/-+./&,*+-'-,1111120101/0%+//+)-(/,)1++%+,,--,00-1)/..)(//-00&-,-(*//)+/0*110+/.1.0,*,.2..%-.,11111,0120011/2/2'/.,-0001//$()%(442151-1%10256%03/-543.*4653520-46535,523./2.066/45565+52-(136033)3/560'331/1343.1/0.'-.(2,,)/(,/.-+-$-)00//&435521/,'$(/&/2.-2-626505/612/02.14/65425255345033,(0.-/52,365665.22#33-)-*(*+,/+-(-/2551$32$#.0)(4/.1465526156551/655553332.1223360-63,)1/5-.23/564,54404&1/&441.432635,42665..//& @rCer/1220/24_1733_CCS ATGGCGAGCGCGCCCGAGCGGGAGGGTGCGGGTGCGGGTGCGGGCGCACCGGCCATCACCGCGCGGCGCGCAGCGGACACCGGTGCTCACGGCCTGCGGCGCCCGCCACCGGGCGGACCGCGAACCCGAGCCATGTCCCATGAAAAGTTTTTGGTGTCTGGGACAACTATCCCCCCAACCCTGGATATCCGGGGGCCCCAGCCCCATGCCCCCCTAGCTCAGCCTCCCTACCCTGGGGCCCTTACCCGCAGCCTTCCAGCCCTCACTCCTACGGTCAGCCAGGGTACCCCATGGCCCAGCCCCTACCCCCAAGGGGCTACCCACAGGCCCCTACCCCAAGGGCCTACCACAGGGCCCCTACCACAAGAGGGCTACCCACAGGGCCCTACCCCAAGGGGCTACCCAGGGGCCATATCCCAAGCCCTTTCCCCCAACCCTATGGAAGCCACAGGCCTTCCAGGACAAGACCCTGACTCACCCAGCATGGAAACTACCAGGAGAGGTCCCCCATCCTACTATGACAACCAGGACTTCCCTGCCACGACTGGATGACAAGGCATCCGACAGGCCTTCATCCGCAAGGTTTCCTGGTGCTGACCCTGCAGCTGTCGTGACCCTGTCCACGGTGTCTGTGTTCACTTTTGTTGGGAGGTGAAGGCTTTGTCCGGAGACGTCTGGCCTATATGTCTCCTATGCTGTCTTCTCATCTCCCTCATCGTCCTCAGCTGTTGTGGGATTCCGGCGAAAGCACCCTGGAACCTTGTTGCACTGTCGGTCCTGACCGCCAGCCGTCGTACATGGTGGGATGATCGCCAGCTTCTACAACACCGAGGCAGTCATCATGGCCGTGGCATCACCACAGCCGTCTGCTTCACGGTCGTCATCTTCTCCATGCAGACCCGCTACGACTCACCTCGTGCATGGGTGTGCTCCTGGTGAGCATGGTGGTGCTCTTCATCTTCGCCATCCTCTGCATCTTCATCCGGAACCGCATCCTGAATTGTGTACGCCTCGCTGGCGCTCTGCTCTCACCTCTTCCTGCAGTGGACACCCAGCTGCTGTTGGGGAACAAGCAGCTGTCCCTGAGCCGGAAGAGTACGTGTTTGCCGCGCTGACCTGTACACAGACATCATCAACATTTCCTGTACATCCTCACCATCATTGGCCGCGCCAAGGAGTAGCCAGCTCCAGCTCTCTGTGCCCGCTCAGGTGGCATGGCTGCCTGGACCCTGCCCTGGCACGGCAGTGCCAGCTGTCCTTCCCTCTCTCTTGTCCCCAGGCACACTGGGGCAGAGGACGCCCCCTCTCCAACCCTCCATATGTACACTGCAGATACTTCGTTTGGACCCTGTGGCACAGCATGGCCCCTTTAGTCCTCCCGCCCCGCAAGGGGCAACAAGGCCACGTTTCTGTGCCACCTCCTGTCTACTCATTGTTGCATGAGCCTGTCTGCCAGCCCACCCAGGGACTGGGGCAGCACCAGTCCGGGGAGAGGATTGAGCCAAGAGGTGAGGTGCACGTCTTCCTCCTGTCCCAGCTCCCACCTGGCGTAGAGCACCCTCCCCCCACCCTGGAGTGCTGCCCTCTGGGACATGCGAGTGGGTCTTATCCCTGTGCTGAGCCCTGAGGCAGAGAGGACGGCATGTTTCAGGGAGGGGGCAGCCTTCTCTCACTGCTGTCAGTGAAATTCAATAATGGATTTGCTCTCT + #$"%"$$$$##"""#$#''$&#$%%('((%(((%(%&%(((&))(((())()&&(&((')%((($'%%&'('#$$'$'&()$($'($('#&)()%(%()'$#))#$'%')&))#%'$$$%(($)$&(((%&)(&((%&((((%(##"!%'$%#%(('&$$))$'%(%%#""$#&('$'$$&($'&$'$%'"%&'&%)))'(#"$&##&#(((('&""''((%&('%)('(')(%%)))'))%((())((('#'#&$(((&)(%%&'$$&$&%()$'$(()(&''$%#((($'$%#('&$&)))('%'(&'()%))(#$%$((((&#'$)('%(&'))#&$')$&$%$$&(($&&$))($$%)$('&(($(($$(())'&#"&$#)'''#(')#%$(&%(((#$&%#'''#'(''%&))%%&#()#%&%)*-.,,$,+(*'$&$#*(,(,,',+-++$,**-,--.,(%*),+(&&)&$()*(*,(,.(+*+,,)-,&'(&&&-*(+,+-,',-)),,+'+*,*,(*%$*+)',,-.(,&)"##%&))-,*&+)%'##(('',,))'%)&'(-))*-.,+(*(%%(*&&)'**++&++,..'(&'$#'%&)$*+%"'+*+&&-,+%)(++('(+((-,(,)--,+%('++*&)***,&,+&&,((++%**)$),+('''"'(##*%'(*,+*+((*''+,*,.,$'),)(',-+-))%)'(+)--*,,**-(+#&&%#)-.).0/+00-,,)/1*--),/2%**&+%+&//*,/-1+(0-,-+--(-//-.#(%.//&'%-/'$-.')+&*(*'.*/,*/+*00'0+,---+'11+10'/','0$.*1/,%,)'+0.(-/0+,.0-..'*-.20--*.010,+0,/-1,00011.-./0(111/-),++-(,))*+,+-&*'-(0/)%+,'()./(+/,--1,.%.+%,,)-++*00.-.---0',,,+/0+11/&.0.2110-2--*2/20-*0-1.#%#*-,/0/'*+,2.,-&('-//.-/0-,)($*0.2,#%-(/,',,00*,),.%/00%.0,00+,1$-+--2012-1/,//.,+20-0.)&2/2+1&)+00,&+($,//&.00+-1/$*//0,,-11.-,-,)/,(1-10/"$)02+,+,+-,+0,/.,.'0-/.2,/'2/.+),'+)/*,+//'+)/+-0/,,,+,,0*00-0020/./().,+0-1/(//+'+0*%/0)1/*'#,,)-2-/1,..*-+0&/0./-00,0-/&0+)/00,,'1,-*022/+10/-(#,'0++0*.-,00&.%0/.*,0.0..1)0.*&/*-+%,.*0)0.--,-*-)&$.,#),.(.)$/1-.,'(%%)/,,//*/&./.).1.%.%-*,00'(-.1%%(%)/1/-&.-+1%/0011,#,.-+,-/&/0,1.&/+000-/-+1/%.(-2-0**.'$)/)+.*,002.,'100(120'0/,.(&/+**,'.0-0/&-'0$//.+()$0-,10--)--2'-,.,/-*.++,/*-00&('0/+1/00,11-*),(21'"'*&/**--+/0/0&0/&'...,-)(+(.%-.&*-.*-/20--'%00,*.0//$$$%'//.-&---,00,-*+00./*$.-)/0%./11*.0,0+0'1%)-+#('+'$))*&*)+,+,,&+&&$),+)##%"&),(*(')+(-,**$*-'$)'#)((,-,,,,,)& @rCer/1222/1741_58_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + KKKKK@KKKI7KKK=KJKKJKKKKKIGKHJKJKJ;KKGKKJKKKKFKKKKKKKKKKJKIKKKKKKKKKKKKKKKKIKKCKKKKKJKKKK/KKKEKJIKKKKKKKKKK8IK7KKKKKKKKKIKKK=KKKKKBKHKKKKKH/KKHK8KKKKJKKKKKKKKKKIKKKKIAAK&KKKIKKKK'KKJKKDKKKJJKKAKIHJFJKKKKKKJKK'KKIKKKKJIIKKKJKGJKKKKKKGKCKKKKD?KKKKJIKKKKJKKKKJKKKKKHKKKKKFKKKJKCKJKJIKHKKDKKKKJKKKKKKKKKBKKKKKK9KKKKJKKKCKKKKKJKKK5KKKKKKKK:KKKKJJKKJKAK;KKKK/KKKKJKKHKKKK1KKKKKKKKKKJKBKKJIKKKKKK'KKKKKJKAKKJJEAC;JK>GKFHJKJ;JKJKK'IKDKKJHKIK>KKKKGKKIKIIIKHKHKKKKKKKKIHKJEK>KKKKKKKEKKKKK?JKJKKKKKKKHKKJKJEJKKJKJJJJKKJKKJKKKHJIKKKI%KK.KKKKJKKIKIHKKCKKKKKKFKDIKKIKKKKHJKKKKKKKKKK'KKKKK?KJJKFHKKKFKKGJKKFKJKKKKKJJKKKKH6K>JKJKKKKJKDKJJKJJHKKJKKHHI/BKGKKJCHKJKKKKDKKKKKK;KJKJKKDIKJJKKKKKAKJKK=KIGKKKKDJHJKFIK>KJKIFKKKJIDJ?K3KKKKKK5KKKKKKIKIKK>KBKJIJKKIKHFD@JKKKHKJKBKJKKJKGKKK@KHKKKJKKJHKKKKKKFAJKK,IK;K?JAJKJIDGHKHKKIKIKKKKIJKKKBKKJKK8KFKGJIKKJKK2KFIKKK87KKEKKKKJJKKKJ>J==J&KHKGGFJKKKKKKFKKKKKDKJKKKJKJIKJK@HEKKKKK9KEKKKKKKKKIKKJKIKKJKKKKKKFKKKIKKKKKKKKKKKFKGKKKKJKAJKFKK-KKIK;HKKJHKKKKKKKKKFEJKJIIJKKKKKKJKKKKKKJKK?KKIKKKEKK@FKKK/KKKKKKKKKKKKKHKK @rCer/1223/2711_52_CCS CAATGCAAGTGGGTGAGATCAGCGCGGCTCCGAGTTCAAGACGCAGCCAGTCCAAGGGGAACCCAGTGCACCTAAGCTCGAAGGGCAGATGGGAGAGGATGGAAACTCTATTAAAGTGAACCTGATCAAGCAGGATGACGGCGGCTCCCCCATCAGACACTATCTGGTCAGGTACCGAGCGCTCTCCTCCGAGTGGAAACCAGAGATCAGGCTCCCGTCTGGCAGTGACCACGTCATGCTGAAGTCCCTGGACTGGAATGCTGAGTATGAGGTCTACGTGGTGGCTGAGAACAGCAAGGAAAATCCAAGGCAGCTCATTTTGTGTTCAGGACCTCGGCCCAGCCCACAGCCATCCCAGCAACCTTGGGAGGCAGCTCTGCATCCTACACCTTTGTCTCATTGCTTTTCTCTGCAGTGACTCTGCTTTTGCTCTGTTAGGAACTTGAACACAAAAATTAATTTGCTTAAAAGCCAGTTCCTATGAAAAAGATCAGTGCCCCCTTTGGAAGAACCTGGCAGGACCACCATGGCCACAGCTGCTGAGCGACCATTCTGTGTGAAGAGAAGGTTTTGCGATTGGAAAAAAGCTTTACCTCCAGACATTGTTACCACTCACAGATACTTTTGTGCTACTTCATAGGAGTTTGCCCCTTTTTAATGGCAGTAAAAAGAATTTGAGAGTTCTTTCTTTAAATGCTATTTTTTAAAACCATCATGCTAGGTTACAGAGAAGTTTCTGCATATCTGCTACTTGTTGCATTTTGTGTTCAAACTAATATGATGTAGCAGAGGAAGAATTCTAAGTACCTTCTAAAGCTTGTGTTAGATTGTTAAAATCACCATGCATTCCCCTCATTCTAACTCTGTGCTCCTTGTCCTCCTTCAATAAGTAATTGGCTTTGCTTGCAATTAAGCATTTAGGTGCCCATGTTAAGAGAGTCAGACCGCACTGACTCACATGAGCATTCGCTGACATGATGAGCAACTTAAGTCACCCCTGTTGCCATGCACTGGAAAAAGTTGAATTTGTTGGATATTTTCTGGGGCTGATGAACGTTCTGGATGTGCTTTCAGTCCTCGTATTATGGCCAGCACCTCACACTGTCTCTGTGAACAGGGCAAGCCGTGATGTGCCAACAAGTGTCAGCTTCGAAGGTCTTTGCTCCCAATCGGGGTGACTCCCCTGCTGCTGGCAGCATGTCACAGATCAGCACAGAGTGGGGCTGTGGTTCAGCAATGACCACAGAATGGCTTTGAGCATCAGTCTACAGGACAGGTTGGAAGCATCCACTGTGAACCAGGCATTAGTGCCCTACCTGGCCTGTGCGTGTTCAGTAGAGAAGAAGGGGGGACAGGCCACTCCAGACTGCTCAGCCCAGGAGGGTTAATAAATTGGGGCCGAGCCAACCTGGCAGTACTTCCTGAATGTCCCAGCCTCTGTATTGGTGGGTTGGTTCAGTGACATTTTCTAACTGTCCTGAAAATCCAGCTGCTCCTCCTGCTGCTTGGGAGTTCACCGGGAGAGAAAGTGGGTGTGTTTTGTTAAGGTCCTCGTGGAGACTCAGGGATGAATCCTGCTTGGTAATATCAGTGTGTGTGCTTGGGGATGGACCTTCTATGAATAAAACTCCTCCTCCCCCCATTGTGGTCACATATCATTCTACATATCTCATCTTTGAGCATCTCCACGGAAGCTTGATTTTTGTTCTTTTGGTTTCTTTATGTATTTTTTTTCTGTTGTTATTATTTTTAATGTTCACAAGACTAGCCATTCCCTTTGGGATCCGAATGACCCCATGCTGTGGTCTGAGGGCAAAGCCACCTATGTTGGCGCTCGCCATTAGTCCCTGCGCTCAGTTTAGAGGTCACGTGCAGACATCAGAGGCTCCATGCTGTGCGGTAGCTCAGGCAGGGTAGTGCCTCTCACCCCAACCACAGAACTCTCCCCGTGGAGTCCCAGATGGCACTTCACACCAGGGCAGTGGAGGCAGGCATGGTTCTTGGGACAGGGCAGAGCATAAGGATCACAGGTCAGTGTGGGAGAGCTACTGGCTCTTAGGATCGCCTTGGGCAGAAGTCACATGGCTTCACCCTAGTAGGGCCTAGTTTGGGAGTCTGCTCCCCCTGATCCAGGACCACCACAGGAGAAGGGCAGTGTCACTTTCTGAAGGGACCCTTTGGAGATCTCGTCCTAAGTGTGGAGAGGACTGACGTGGCCCTGTCCCTCAACGCATCCAGGGTCAGGCAAGTCTCAGCTGAAACAATGTCAGGGTCCTCAAGGTCCCATTTAGACAGACCCATGGCTTGTACCAGTGCGCCTCTCAGGAGGCAGCATTAGCTCACACCCACTCCCACTGACACTGAGTTCCCAGTGATGGCTGCAGCCTCCAGCCCCGCAGGAGTCTGAAGACAGCAGCCCTCAGAGACCTGCAGGAATGAGCGCACCCACCTTGCTCAGCTGCACCCCACTCCCCTGTGCCCTGTAGTTGTGCTGCCCATGCTCCACACACCATGGGGCTCCTCTGCTCATTTTGGACTATTTATACGGCAGGTTTGGATCATGTTTTTCTACTAACAAGAATGCTAACATTGTTGTGTAGATAATCAGTGAGGCCTTTATGAAGTTTACACCTTTGCATTATTAAAGGAAACAATTCAT + ,(+'%,-%#(##$'''&&**%))(+'&'*.*0,*2101,11+&,101-1-.1-0,/-0.2+)0*.1,*,01.00-(*'0,0,,+&11--/-+&0010/1&''01)000+%0&1215404,1../5441+00.*),&1004.3($',.0/4&51415623311/235+0.*301-)&+-%+-.0///.,-+1*310*,2%/0'-/*.2/56-,335*//2.6.4,*/*15)2250/551415610122/1-+0/)1,,,,&,11-(.'--'101.-/*0+(%-2011/.*0()01,.&1,+1.***%,*-+-.%*11/000')0.++*+0(-,,-02,11+/,-.&,++/-%+,(.)(/,2'/-0,12-1-*01--',..+-10,)*..-(2.-,1.-01.-0-222-*/,/,.),(11/)&-*,+*/&-)&**-/$+.(,&,11,1,-++,11-*.&0'/0(,*3)40)*-4+/32+++5515365321251/,+37459'6.&426,4902,38*614217424/+-3+431837,64351629743'37//*'24'%-,1-2.)/*897/97:78%,/;:7:1/7-17*15.6:364)2+,$(9+59-8982-/35481/.683442982-/2+.-'5'3593'-667%.119-5348-+,2521.1'75$9:-543,892-050216&74&510-,6::85,126%8.4///5/).-/.9%$0520141498,/-',,8/.&686986;87997,.4:41541:3141%&/5%61735)0/-4-+229.3226))'&/(%)15:0:8/889--4:57727431(3,370.+.#22(-'1/,.,*059608433+203*,4-.1+7''6&7567423+%8.47.25,.02+53:-127)34636-3*5%,*)1041'4:5518605::;25&.5776141/979986/3+4968429:934./2$8784.0997(406312816536/5+54+11(0.1'54/2*84/-3:12./2%16.:;65709956+/:7615,&2247%+850478167;6967&408396;9698/97'657869,68;68(-2-57&0/003/343-135::86/42:9-&+-84'859849:8828749,8:7:854)84530'3475;;96$322%9)4,486-75213798(54.+'$3728/8558856965711404,0408155515&835-927'82/9:,8206$)3264,,;5568(532634.&844:859;44(5:374624,4,(40,*70865846/5976790988657%901.1322(378684.4.&.40*3496:4664:7),6-5352/-&*(/5'2/2267249426/%5522:7676;9499182::9040147076(4099/265998521#3530.2-46&6,-)9:5:632-51799.98:20%7775601,::4--16'28841&520-+%,;9::/:5'03*14%38+3333.48'23632'9,,/)10347:31-2-%.2/273:1-90929305)3461:4-42+134;;48013,:60:6695814:/0043/1395345.--61764)%3914:495+0#*4:4)4.7$#25'21(1)1137(5?>=08/::1682*6-+<19=7172=:8:8969686=5=7=:184$108/7'17>48/4::5&3610<7/%1.8855=9;9;4875668630%).02%$0*35-151.,-207;<3,)&-%2392;92)3<18>+6*'=;.4$(.9:80*6348.05:86417344*3467'+01*9:/-(&=3002390+488//,')-*.(/%%#"')./556234'.--(#.415561///54/)3-+)-(1.64520230/-*00055-$+/5.+013+)./245*51524123'616/-/,44+'210(22&$15.0+/.,#33//2'0,23.2.--1)-44*021%/-051405.0005//,1403-"*,/04**41).1+56,6143/21.3(04102.166/2303-1-520''/$2*2.*-+256.5/2.+-/,.(3.*,).46225&.302'//0.+/1-3-40364/./&-*,,(.*0/3,-(-3)*2$.61,4).2$/206252026...030()##(/2-1.43+12-+00&66.1.30*04503/,%.../21-321+.10,0.5553*-'.6.11104',23.32/1/.%/40/55441123*-.5150*.346,(.$)01'1/3..4+55113$/35)102(02002540.),.60-2-1*(53624500/(+-(*+..31,*(4123'..2///.,-,(*+045)1/3%3231.)0*4/..$0*//1261.0.)'24+-2-.)/04&2+/3,)2-#++1)-55504-,./'0)44251)&0...,&'&1,)2.//+.1$)0',-1*..++&0*%))'.'.(01,-,-,*+10)/1/./1+'+,10//0%0*/-)2/+1/,-1-,1('*(,,1*.,',./&),,,$+)-)/'$/),0+)*'++,(11-0'-0-),0/0/.&/,&0*2/+--+.*,(.+,/,12++-(-1-,,'//2(&-*11..1(*%.+$.0,)''10(/-,-%//&)1.+%0/%02+.()$#)-,/*/+) @rCer/1224/1665_55_CCS ATGGGAGAGCCTGCGGAAGGCGGCGGCGGCGGCGGCACTTGCTAGCAGCGGCTAGGGCAGGTTATGGTGAGCGGACTGCGCTGTGAGCAGAGCGGCCGCGGGCCCGCCATGCGCCGGCGGCCCTGACATGGCGCCAGCGGTCCAAGCTCGGGCTGTGGCCCTTCGCCTCGGCGGCCGGAGGCGGCGGCTCAGAGGCAGCAGGAGCTGAGCAAGCTTTGGTGCGGCCTCGGGCCGAGCTGTGCCCCCTTCGTATTCACGCGCCGCGGCTCTATGTTCTATGATGAGGATGGGATCTCGCTCACGAGTTCTATGAGGAGACAATCGTCACCAAGAACGGGCAGAAGCGGCCAAGCTGAGGCGAGTGCATAAGAATCTGATTCCTCAGGGCATCGTGAAGCTGGATCCCCCCGCATCCACGTGATTTCCCTGTGATCCTCTATGAGGTGTGACCTGAGAGGTGCAGACGAAGCACCCCTGCCCAGCAAGAAACTCCAGGCTCAATCAAGGTGTGACTTCCATTGAGGAGCCAGGCTGGGCCACAACCCTGAATAAACTCCATTGGCCATAACTTCAGCTGTGAGCGGTCAGTCCCGCAATATTAGTTGGTGTTGGTTTTGTATGGACAAGAGGTGTTGTGGGTGGTGAAGCTAATGCAGAGTTAGCACCCCACTCTCCCAGCCACCCTGCAAGAAGCACGGCAGGGCATATAACAGTCAGGAATGCCCGTTACCTGGTTCCTTGCCTGGTCTGCCTTCTTCCAAGTTTGCCTGGGCCTAGCCTGCTAGAGGCTACAGCACTTTACAAGCAAGGTATGCCTTCTTCCAGCCCTAGGCTGTGGGCACTGTATACAAGTAGGAACTTCCTTTCCTTCACTTCCCTTTAACCCCTAGTCAGAGCATTTCAGCCGTTTGCTACTCGATTCCTCTGTGTTGGACAGAGCTGGGGCAGTGCCAGCCTGATTCTTCCAACCTACCTGCCATTTGTTCCGCCTTCAGATGGATGGACAGTTTGCTGGCTATTGATAGGAGTAGGGACTGGGTGGGGCTTCTCCTCTACCCAGGGCTGGCTGATCCCCTACTGCAACTAACTGTTCCCCCGCACCCAAACCCCAGTTGAGGAATTGAGAGGTGCAGGCTGGGGTCAGGACATGCTGTGGATGCTTGTGCCTATGGGAGTTATTCCAACCACCTATTCTGTCTAATCCCATGGCTTTGCACCAAATCCTCCACCCTCCAATTGGGAGGGACTGTTCACCACCTTGTGGTAAGGACAACACCCTAAGGCTGGTGCCAGTAGTTATGAGTAGCCTACCACCCCCTCCCTTACAGTAACCGCACCCCTTCAGGATCAGTCAAGGGAAAGTACTAGAGCCCTGGTAGGGAAAGAAAGGAGAGAAAAACCATAAAAGGAATACTTATAATGTGAAGGTTTGTAAATAGTCCATGATGATGTCGTGGCAGAGTCTGATTCTATATAGAGTGACTTTTTTTTTAAGTACTGTGCAAGCTCTGTGCTTCTAGAATGTGGGAAGTGGCTTGGGGAAGATGGCCCCAGCCTAGGAAGACTGTTGTGTTATTTGTTCAATTTCAATAAAATGATTTGTAGATCCT + 7ECB2=EHAG+>DAF7D>AA=8+6563?37=,@)&8BBF;5B@BIF?AHH>;A:IG':-D0G3E6A;:%45B?2>2D;AAA4@BHIGE-.:-)>%E/8/DD()1FA%,DB;;7DC->E9C/;DEBF?('5,/B(AD&A8GEH@@BC,>F2H;A'??&FC,IF%6E=:0:J@F?@GJDGFIHBG:G;/C+G5E=BD*.%'<I8AIAIII?B@@DAE0;CF9GJ?EDFHFEFG8=CBCC:?*H<.DG=ECC9&DDF8II0BAIHKI+HBH;GI;?IC4EE1=%FG9C?(GCD?EFKJ0?AEI5JIFH;IKJ=6+K$IK,C>HIFJIK@K2,7D8GHJIJEJKGEKJAKHI8GK8EBGE&BIJDDJH7?CK1IIF?.F,IKB/'2/JIKKIJKJGEFH&HKKJJKK2J=K+98K2BID+H#AIKFD8KKK9HIIKH>ICJBBEK:H,44%9DK@KKDC?KE*F9IIKF&JKKJH=CA,H3K.J=HI1HG7>H1JK-KEGK4K6KA=IJ'HI&JIK,3*IFHK:AJJGI4CKC=J,KCBKKJA'HFGIF+IKKIGJ8JHKBFIFH<4I-H6K:KEIBKGHKK.IJJBGKEK';A/D.IJDGHH6CII=DGKIKJ2E@DK8GE6K+EGI;K$IIJIJK*H?9KK7JHHK'6KDKKKEDJDJKK'FKJ)FHH0JKKIBFJJ#JGCGKJJFD?KKJDEK@K@DK2DCA;D);E0EIK*KAKCJKK?K;K8KEJJG'9FCFH1>JJJKBGJ?EJHIK@KIK-;KJHI'IJF-KDIJDHJKE>'>(2;CK)KIJ?J;FJCI8JIK.KJ,KK*GJ@?JHKG:IJ2GH'EFJK)KK3DKK1F-HCAFKKKK/D-J@IKK7KIKDGKIKGJFKB<,BBKIKFKK;JGGK9KHJIK-JJIBAE@>FC@HKK/JDA6AFFJGBI,DJIJIDFIGJDDKKKKK%KKHJHBFHHCI@;DJKIKKJHJK8HJKGKCJJKKK7KJAJK8KJGKKJ+K?KGHK8JKI5GJK,HFKHKKJKKBEKAD@:I4JGJ0KK?KKBIK&JKHJJJG*C/GIG7GF=?DGJAB @rCer/1227/604_57_CCS ATGGGGGTCACGCCTGGTCCCTTTGCACAGCAGCCCTTCACACATTTGAAGGTCTACGTCCCTTTTTAAAGCTTAGAGGCACAAGCTCAGGACAGTCTTCAGTAAGGAAATTTGTGGATTTCCCTTTGGATCTTTCTTCCTCTCCGGCCACAAGTGGCTCTAGTCTGACGAGCATTTAAGCTGCAGATGGTGGCACTCCACTCGGGTCTCAGAGCACCAGATGTGCAGGTGGGACAGTGGTTCCAGCTCAGGCTGCCTGTCAGCGTCCCTTCCAGGTGCTAGCCCTGGCAGCATAGCCCTCCCTCATGCCAGCAAAGGAAATGCTCTTGGTGAGAGGCTCACTTTAAAGAAGTCCAAACCGTGTGCTTATCCAAGGGTTCTGCTATTTCAGACTTCACGGCTTGCATGTTTGATTTTTCTAAGAGAAAGAGGCTGCCTGCTGGGTATCTGTGGAAATGAGATTAAACTGTACAATCTGAGTTTTTCAGTTTTACTAAAATGCAAAAATGTACAGTTTCAATTTCTTAAATTGTAAACACGAGTTTTC + KKKKKK&KKKKKKKKKHKKK+KK9KKKKKKKKKKK?KIKKKKKJKKHKK=K&KKKKKKKKK%KKKK;KK@KKKKKJKK4KKKKKKKKKKKKKKKKKKKEKKKKKJKKKK.KK0KKKKKKKGKKAKKJKCIKBKK1KKKKKKKJKKKIKDKKKGKKK>KKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKJKKKKK5KKKKKK6KGKKKKKK(KI4KKKKKKKKKK$KKK.KKKKKKAKKKKKKKKKKKGKKKK1KKKKK>KKKKK)KKK2KK+KKKKKKKK1KKAKJ(KKJKKKK+KKK@JKKKKKBHKKKKHKBKK4KKKKKKHKKKKKJKK1KKKKKKKKKKKKKKKKKGKKJKHKKKKKKKKKKKKKKKK#:@KKKKKKKKKKKKKKKGKKKK=KKJKKKGKKK?KKKKKK%KKK?KKHKK$KKKIKKKKKKKKKKK+KKKKKKKKJKKKKKKIKKKKKEKKKKKKKKKKJKKKKKKK(KKKKKK,KKKKKK9JKKKKKK3KKKKKKKKKFKKDKK%KK9KKKK8KKKKHKKKKKGKKK6K @rCer/1228/25_2070_CCS ATGGGGGCTAAGAGGCGCGGGAGAGGAACGCTTATGCAGCCGCCCCTGACGGGAGCGGGCTCTGCAACTACTGCAGCGCTCAGCGCCCCTATCAAAGCGTAGTCTAGCATGTGTCCCGGCTCCCCGGCTGCAGGGGTGGCGGCGGCTCCTCTGCAGCAGCCTCAACAGCTGGAGCCCATGGCCAAGCCCAGCGTGGAGCTCACCCGCGAGTTTTAAGATGGAGTCTCTCGTTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTTCTGCCTCGGCCTCCTGAGTAGCTGGGATTACTGGCGCGTGCCACTAGGCCCAACTAGCTATTGTATTTTTAGTAGAGACGGAGTGTCACCATGTTGGTCAGACTGGTCTCGAACTCCTGACCACGCCCAGCTAAGTTTTGTAGTTTTAGTAAAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCAGACCACACCTGGCTAATTTTGGTATTTTCAGTAGAAATGAGGTTTCACCATCTAGGCCAGCTGGTCTCGGACTCCTGACCTCAAGTGATGTGCTCACTACGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCCAAGATTTCCCGTTCTTATCTCCAATAAGCCAGCTTGATGGGGAGTAGTGCTATCCTAGTGCTATAGTACAGCTATACTAGTGCTATAGTAGTACTATAGTAGTACTATACCCATACTTCTTGACTTCCTTCTATCCTTTTCTGCTCACAGGCCCCCTCCCTAATGTCTCCTGTGCTCTTTGCAAAAGAAATAGTGCTGGAGGCCAAATAGCAACTCTGCCCACAAAAGGAAGGGCCATGTGATGTTCACCAAGCTCCCAAGCCACAATTCTCTTTTCCCAGAATCCTTTGCTCTTTGAAGTGTGGTCTTCCTCACGTTCCTGCAACGCTCCACCCCTCAGTCAGCCTACCTCTGAAGAGCAGGGGAAGAGAGATCAAATGCCCCTTGCAGGCCTGTCCCTTTGAACCAAGCCCTGAGAAGCCCTGCAGCAGTCCTCCTGTGTACCCTCTCCCCAGCCCTACACACAGATGGAGAGCCCTGGGAAGGGTTTCCACAGTGCATTAGCACCAAAGAGTGCGAGAGGACAAGGAGTGTGGCGCTTCCAGCCTCTGTCAATAATTCATGAGGTCAGACTGACGAGGACCAGTCAGAGTCAGTTTTCCCTGGACATGGGGAAAATTATACTTAAGCTCTCCTATCTCATCGGGATGTGCTGAGTACCAAAGCAGAGTACTGCAGCTGTAACTTCTTGGCTGAGGCAAATAGTATAAATCCAGTGCAGGCCTGTTCTATTACTTGCTTGCCATATATCCTCTTTTGAATGTCAAAATCCATTTTTTTTCTTTTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTCTCCGTCTGTCGCTCAGCCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAAGCTCCGCTTCACAGGTTCATGTCATTCTCCTGCCTCAGCCTCCCGATTAGCTGGGACTACAGGCACGTGCCACCATACCCGACTAATTTTTTCTATTTTTAGTAAAGACGGGGTTTCACCGTGTTAGCCAGGATGGGCTTGATCTCCTGACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAACCACCATGCCCAGCTGAATGTTGATATCCTTTTTCAGCTGCACAGCTGACCTACACATACACTAAATGAATCTTAAGCAAACATGAATTATATTAAAAAGTCATCTCTAGAACTGGATTTCATAAACCAGGATTTTTCCCCCCAGTTGCAGGGGAATAAGGTTGCCAAACTGGTGATTTCACCAACAACACATCTCTAAACCTACCCATCTGCTTTCATCATCTTTTCTGAAAGAAAACACTAACACACACACAAAAAAACGAGCAAACGTATACTCCACAATAAAGGACTTTTAATAAACTTAGCTTCATGAAACTC + KKFKKKKKKFKKKKKKKKIKKKICHK8KKJKKKKIKHHIKKK=KKKKKKKEKKKKKIKKJKJJKKJKKKKKJKK1KKKKIHFEKKGJKKKHJJ;KKKKKJGKKJKKKKIHJHJKGKKKKKJ,KKHBKKKJKKJKKKGJKKIKKEKJKKKKKKKKJKKKDGKKKGKKKKKKJKKJ>KKJKJKKKIKKKKKKKJKKKKIKKJIJJKKIDKKK5KKKKKKKKKKKKKKJJKKKKKKKIBKKIKKKKKKEKKKKJKJKIKIKJKKJ?KKKKEKKKKIKJKK=KKKKKHHIKKAKKKJK>KKJKIIKKKKJKKKKKKKKKIKEKKJKKK>KKJJKK.KKKKKKKKKKKKKKKJKKKKKJJKEKKJKKKKKKIKKKKKJ@KJKKJKIJKKJJKJKKKKKKKKKKAKJJKKKKKKKKKKKKJFKKG>KKKFKKKKCKKKKJKKKKKKKKKDKKKKKKKBKKKEKKJKKKKKDKKKHKKKKHKKKKJKJKJKIKKKKKKHHKKHKKKKJKKKKJKJJKJKKKKKKKK;KKKKKKKFKKKJKKKKKJKKKKJJKKKKKJKKKKJKKGK?KKKKGJKKKKKJKKKKDKKKKJKJKKKKKKDKKJK5K>KJEFKJKJKJKKKDKKKKKKHEKKJJKJKKKKKKKKKKKKJKKJJKCKKHKEKKKKKKJKKKKKKEKHJKGKKKIKJKKIKKKKKKKKKKIK5KKKJKDKKKKKKJKKKKJJIKKJKK>HKGKKKKGKKJKKJKKKK?KKKIKGKKJKKJKJKK>KGKIDKJKIKKKHKK:KKJKJHKJKJKJKJKKKGKAKKKKKIJJKKHIIK8KKKKK>KKKKKKKKKKKKKKKKKKJDKKFK4KKKKJKK?KKFIKKKKKKKAKKKKKIJK=KKKKKKHKKKJEJKKKKKKIKKEKKKJKGHKJCKHKHGJKHJI/IHBKJ;KHKJK6KGJK7IKK>KIKKDKKFKFKJJKKKKKKKFKKKKKKKKKBKKKJKKEJ=KKIIKKEKKKJKKKK:KKKKKJKDKKKKKKIKKKKKKJKKKKKKDKKKDKJKKKKIKKJKKKKDKKKIKJKIGKJKKKKGKKBKKJ=KEKJKJCKKKKKKCKKDKKKKHJEJFKKGKKJKKKIKKKFKKKKH.KKKJI@FKIAEDJDJII9E;KKJ;JFKKJ?KK?KJKKGKK?KHJIKIJKKKKGKHJKKFKKAKKKIKKGJKIKKKKKJIJII?H;FHKKHKKIKKKKKJDKEIKKKKKKKIKKHKKGK@KIKGKJKK;KKJJKI9A>CKJFKIIHFK>?JHKIK;KKFDGJCDBKII;KJIKIIJK;GFKIH>KKKKEIIJII2FIJKKKJ1KKKKKKKJKHKKKJJKHKKKJKGKKKKKKKEGAKKHAKKDFKKKHKKKKKKDKFKKKKJKKJKKBAKKJKJJFIKGJCKKKKCKHKJCKJKHIIBGJ@BKK=KGJIKKKKHKKKGKKJKJKJKH4KKKIKJJKKI=KJJKKJFFJKJJJKDHKJ6HKKKKKKJCJHIKKKKFKK?JJKJKKKKK:KKEKJKFKKKJKK;KKKFKIKKEKJKJHDJKJIJ @rCer/1229/25_961_CCS ATGGGGGGGGCGGTGCCCAGCCAGCTGGAGGGCTGGAGGCGTCAGGCGGGGAGGGAAGCAAACGGCGGGACCAGCGGCGACGGTAGCAGCAGCATGGCCGCGATCTATGGGGTATAGAGGGGTGGAGTTGTGCTCATAGCTGGAACAGGCTCCAACTGCAGGCTTATCAACCCGATGGCTCTGAGAGTGGCTGCGGTGGCTGGGGCCATATGATGGGTGATGAGGGTTCAGCCTACTGGATCGCACACCAAGCGGTGAAAATAGTGTTTGACTCCATCGACAACCTAGAGGCGGCTCCTCATGATATCGGCTCCGTCAAACAGGCCATGTTCAACTATTTCCAGGTGCCAGATCGGCTAGGAATACTCACTCACCTGTATAGGGACTTTGATAAATGCAGGTTTGCTGGGTTTTGCCGGAAAATTGCAGAAGGTGCTCAGCAGGGAGACCCCCTTTCCCGCTATATCTTCAGGAAGGCTGGGGAGATGCTGGGCAGACACATCGTAGCAGTGTTGCCCGAGATTGACCCGGTCTTGTTCCAGGGCGAGATTGGACTCCCCATCCTTTGCGTGGGTTCCGTGTGGAAGAGCTGGGAGCTGCTGAAGGAAGGTTTTCTTTTGGCGCTGACCCAGGGCAGAGAGATCCAGGCTCAGAACTTCTTCTCCAGCTTCACCCTGATGAAGCTGAGGCACTCCTCCGCTCTGGGAGGGCCAGCCTAGGGGCCAGGCACATCGGGCACCTCTTCCCATGGACTATAGCGCCAATGCCGTTGCTTCTATTCCTACACCTTCTCCTAGGGGGCTGGTCCCTACTCCACCCACTCCAAGCTCAGTGGACACTGGGTCTGGAAGGAAGGAGTCTTTTGCTTCCTTTCTCCTTTTACAAAAACAAACATAGAAGAAAATAACGCACTTTATCCACTCCCCAATTGGACTG + 79(:5238;56D:F=D>E>*=@:0+<;:C>=>F?4::,BCE,1GB4E2>0A@=;A?-@@B>C9CF+?@ECA6:8:@<5>=?B>?8,@,3B?A<;245>,AD>488=>;=G>D98=:=98?<7=;;:A>@FF;F4?C=4?8:?A=C@?64>-AA;C8HD9KB?'B,>537*3=98DEAA@==3==B468469)60<9@BDGFA,CIEC69?C?@EAE@@FBCGACC=AH8A8?E=JDDBGJ7E;H?>HHE>:CI-A;:AI>8B6FGF,CHJ>=4?78GABF3:=@=34431@&JIH6)-:3BCEF58-,7=B=A=%::C@CGD7IF5IC<84;>I4CAI?BHFA1ADI@5@@7>ECHE9H;B>DBK6C0GBAC(DE<9GHFIDHFEJJJ4CA?=@B?EF?1AB3@DE0?:FF5@>CBGIDIIFJFKGD;GD@KJH<-7GDEKK@89;.A=A$AH11JI:ID;$:K>>K>1BCII=JJCJGJGBICE..&FC@A<@H>;GAKKAEJ?3@A.KIIFB=2CA1FD@?F<,HGGIKHJBEI9IAKHKHKK1KI@HFB5KJCABHHEKEKGKCK=CIFK@KJ?IHK%JGGG=*==>;B6=A>CDCC8I@1AF;%&KFJGDH(HHI=>H??:1KHCEH/C>FGBDC @rCer/1233/1971_59_CCS ATGGGCAGAGGCACTAGAGTCTCAAGAGCTGTGTGAACTGAGGTGGCTTCAGTCCCTCAATATGGAAAGAAAGACACAATCATCAAGCCTCTGTTGGTTGAACCTGAAGGACTAGAGAAGGAAACAACATTCAACTCCCTGCTTTGTCCATCAGGTGGTGAGGTAGCTGAAGAATTATCCCTGAAACTGCCACCAAATGTCGTAGAAGAATCTGCCCGAGCTTCTGTCTCAGTTTTGGGAGACATATTAGGCTCTGCCATGCAAAACATACAAAATCTTCTCCAGATGCCCTATGGCTGTGGAGAGCAGAATATGTCCTCTTTGCTCCTAACATCTATGTTCTGGATTATCTAAATGAAACACAGCAGCTTACTCCAGAGATCGAGTCCAAGGCCATTGGCTATCTCAACACTGGTTACCAGAGACAGTTGAACTACAAACACTATGATGGCTCCTACAGCACCTTTGGGGAGCGATATGGCAGGAACCAGGGCAACACCTGGCTCACAGCCTTTGTTCTGAAGACTTTTGCCCAAGCTCGAGCCTACATCTTCATCGATGAAGCACACATTACCCAAGCCTCATATGGCTCTCCCAGAAGCAGAAGGACAATGGCTGTTTCAGGAGCTCTGGATCACTGCTCAACAATGCCATAAAGGGAGGAGTAGAAGATGAAGTGACCCTCTCCGCCTACATCACCATCGCCCTTCTGGAGATTCCTCTCCCAGTCACTCACCCTGTTGTCCGCAATGCCCTGTTTTTGCCTGGAATCAGCCTGGAAGACGACACAAGAAGGGGCCCATGGCAGCCATGTATATACCAAAGCACTGCTGGCCTATGCTTTTGCCCTGGCAGGTAACCAGGAAAAGAGGAAGGAAGTACTCGAGTCACTTAATGAGGAAGCTGTGAAGAAAGACAACTCAGTCCACTGGGAGCGCCCTCAGAAACCTAAGGCCCCAGTGGGGCATTTTTACCAACCCCAGGCTCCCTCTGCTGAGGTGGAGATGACATCCTACGTGCTCCTCGCTTACCTCACGGCCCAGCCAGCCCCACCTCGGAGGACCTGACCTCTGCAACCAACGTCGTGAAGTGGATCACGAAGCAGCAGAATTCCCAGGGCGGTTTCTCCTCCACCCAGGACACAGTGGTGGCTCTCCATGCCTGTCCAAATATGGAGCAGCCACGTTCACCAGAACTGGGAAGGCTGCACAGGTGACTATCCAGTCTTCAGGGACATTTTCCAACAAATTCCAAGTGGACAACAGCAACCGCCTGTTACTGCAGCGGGTCTCATTACCAGAGCTGCCTGGGGAATACAGCATGAAAGTGACAGGAGAAGGATGTGTCTACTCCAGACATCCTTGAAATACAATATTCTCCCAGAAAAGGAAGAGTTCCCGTTTGCGTTAGGGGTGCAGACTCTGCCTGCAACTTGTGACGAACCCAAAGCCCACACCAGCTTCCAAATCTCACTAAGTGTCAGTTATACCGGGAGCCGCTCTGCCTCCAACATGGCGATCGTTGATGTGAAGATGGTCTCTGGCTTCATTCCCCTGAAGCCAACGGTGAAAACGCTTGAAAGATCTAACCATGTGAGCCGGACAGAAGTCAGCAACAACCATGTCTTGATTTACCTGGATAAGGTGTCAAATCAGACACTGAGCTTGTTCTTCACGGTTCTGCAAGATGTCCCAGTAAGAGATCTGAAACCAGCCATAGTGAAAGTCTATGATTACTACGAGACGGATGAGTTTGCAATTGCTGAATACAATGCCCCTTGCAGCAAAGATCTTGGAAATGCTTGAAGACCACAAGGCTGAAAACTGCTTTGCTGGAGTCCTGTTTTCAGAGCTCCACAGAAGACACATGTTTTTGTATCTTTAAAGACTTGATGAATAAACATTTTTTCTGG + HHKK>?BI=G?A6FHJJJJJGAIJAIJHGJIJAF%C<7IKGJ:KKCID2EJHEJK?JJF8?8<=2BK>FHH7BA==0@@JKKHJKJDG3GA@IJ7GCHCFHBB@CKJCK-CFKA4IHH7J8IC8C>4CCG;6;0>DIK>JJJKE?CCIDHIHFIHIBCAGJ@HHHI;E>6A=9?DHC4HJE7BHJE;HCAEG:JFJK>HHJFCHIEEFIIB?0>FFBH=HEJHGFIIHJFI7;I&G;IIF2BD@FH=HJJIFI1KJIKIHI1GHD@>CGK5JKKEIIK@JKIFEHJ,C49KJDFIBE@BHFHIEHHHFC7$EHBIFIK'KKJKGIJJ@JHKCJHKHEE@H7@CB@?6::7G>HK@<@;JCGHCK9II)3A>EEI;FFCFF:F<=8;;C<3DHD?C=?F?BD9J?D>DJKHKFKDD=DBDEI;FIC?FHBID>:*D@BEGG=GGACHJJEHKDHHEFEI0?@H.HCKEBH?BFJ@IFCKJGIEEFJIIJIJIFGAA?DCCGC7?A>=>CF:@IFBAFBB;4FD@@=7F@H?B5IH>EI<@FF4IFF9HGGGA@CE0BFD?=>&FE0>JCF=BFG?F@II@A?;>FFE?IIEBDD=CC@6EH=FGHAIGHFG>@EBC;@IIH>@I9HGHGF>DEFFHIH8CBFIIB4ABD;GJ@@:GHHJFJAGE?HH93CGAFGCEAHHCEHCGEFIGH@F>C5B;FFC70@<>FEDGCJEEEE:FGDI>@C/GCIGDDFHGII&FG?ECH>C9EICJDD@C(EIGJBA=::>=>>/8=AD7?BF0AHFH@GE9GFEDIHGCB@EC4DGD6DIEDBJ=FIE@EEIIJFHDEFG?GJ@IIGAG5GD2AFB=ADA?F)@>2DEE57@9HI=ADF86>HA?@J:JCDBFFD?HD>B@6DF96=HFH=A?@>BBFADCAFAEB8F=>58?3GIAHIGBCAACGF8BHA>A=GDFDFD><6E7;FDDEFA:BFFEDF>GB5J=CDGBIIGHD<;C@FF?C/D=?EBGG866=A.8@>3<;C5ACCAB@@B?<88@.G<$6B:9GC@>:GDEEJCEG97DA7C4D@DHFHD5?/C;HGDEDCDJJEGECBA97?>HIIJ*FEBIG:CGHIBHHFC8D5>.<@FHJ7IAFEIFIEAAE+=EG7C>@H;?FGE/?@D=;EB90E?IDAEEJBEF;797GFAC?=C&II=GHD1DG=;5E@DDCH;IH6C4CGEE>IIHGIGED7('DD;B7>E+EDEFIBE?C83$AD9HCF:HH7EC6ACHC(F:IIGD>@.CB?JHADA=BCBB@FEBHHIFDIF>6E@AGIG/6:JGJA?E=<7:A>CH0?BIII:BEHI=FC?AEJIEC=IA@GAHI3EB=:@;>>??BFCA9C7CB>;FA>AB?7AED3@@E=DDBBE9ABF@@B:.A:@? @rCer/1234/25_1719_CCS ATGGGGTCCGCGGGCGGAAGAGGCGGCGGCGGCGGCAGAAGCGGCGGCGGCGGCGGCGGCGGGAGCCGAGGAGGAGGTTCCGGACGCTGCTCAGGAACCGGGGACTCAGGAGTGCCCGCGCCCTGAGCGCTCAGCTCCAGAGGCGTCATGGCTGAGTACGGGACCCTCCTGCAAGACCTGACCAATAACATCACCCTTGAAGATCTAGAACAGCTCAAGTCGGCCTGCAAGGAAGACATCCCCAGCGAAAAGAGTGAGGAGATCACTACTGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATCTCCCGCCGTCCTGACCTCCTCACTATGGTGGTTGACTATAGAACCCGTGTGCTGAAGATCTCTGAGGAGGATGAGCTGGACACCAAGCTAACCCGTATCCCCAGTGCCAAGAAGTACAAAGACATTATCCGGCAGCCCTCTGAGGAAGAGATCATCAAATTGGCTCCCCCACCGAAGAAGGCCTGAGCAAGGGGGAGGAAGAGGAGGAAGGTTGGACCTTCATCAGACCACTCCCTTCCCCCATCCTCCAGGGGAGGGGGCAAGGGCAACCCACCATCTACCCACTTACTAACCTGGTCCTAACCCCCTTACTGTGCGCGTGTGTGTGCGTGTGCGCACGCTCTGGCTGTCTGTCTATATGTCTAGCTCATCTAGTTCCTCTTCTTAAGGGGATGGGGGTCAGGGGCTAGGGGAGGGGGCTGAGTTTCCCCACTTTAGGAGGAGGTGGGGGCTATTTCTATGCAAATAGAAATCAGCACATTCCTCCTACTTCCCTTTTCCTCCACTCTCCCCCCATATCTTTAAAGTGTGGAAGCAGAAAGGACCTGCATTTTCCTACATTGAGGAGCTGACATGGGGGTAAGGTATGGGAGAGGTAGGTGGATCCAGGGAAAAGCAGTGGGGAGGGAAGGCAAAGAGGCCACTCAACCCCCACCTGGAAGGGGCAAAGAAAAGCCAGAGTTCCCTGTTTGTACTCCTGTGCTGGACTAGCTGTTTCCTGAGTACCAGCAGGTCCCTTTTTTGCCTCTCATGGGCCTAGCATAGGTATGAGCCAGGGATCCTTTCCTGGCCCCTAAGATCAAACCCCATGGAGCAGCCAGCATTAGATGCCCCCACCCACCTGTACTCTGGACTGTGCTGGGAACATGTACCACCGAGCCTGAGATGGGGATGAGGGCAGAGAGAGGGGAGCCCCTTTTCCACTCAGTTGTTCCTACTCAGACTGTTGTACTCTAAACCTAGGGAGGTTGAGGAATGAGATCCTTAGGTTTTAACCTGCATCCTGACCCCACCATCTATAGGGTCCCAACTTGGTTATTACAGGCAACCTTCCCTCTCTCCTTGGTGAAGAACATCCCAAGCCAGAAAGAAGAGAAGTTAACTACAGTGTTTTCCTTTGCACTGATCCCCACCCCAATTCAATCCAGGAAGGGACTTAGGAAACCCTTCTTTACTAGATATCCTGGCCCCTTGGGCTTGTGAACACCTCCTAGCCACATCACTACAGTACAGTGAGTGACCCCAGCCTCCTGCCTACCCCAAGATGCCCCTCCCCACCCTGACCGTGCTAACTGTGTGTACATATATATTCTACATATATGTATATTAAAACTGCACTG + KKHKKKJ9JJK(KKKGK>KKKJKKKIK@KKJKKKKKKJHJIKGKJ=KKJKJ>KBHKKJJKJDDKKKKK;KKKKEIKKJKKKKKKJKKKKKHDK7KKKKKKK6KKKKKKKKJKJKDKBKGCKDKKIKKKKK?KKKC;KJDK>KKKKJKKKKHKK@KKK>%KKHJKKKCKKJGKIKKKIKKKHGJJKKIK-KJEE@IJKKJKJKKKKK0KKKGEKJJKKGJJKKKAGHKKJDJKKKJFGKKKFKKJIKKCKKKKKKKKJKBJGEKKKKKHJKKKKKKKKKKKKKKKGKKJKKAKKIKKKKKJKKKKJKKKAKJIJKKKKJJ9KKKKKGKKJFKKKKKIE?FIKJKKKKKKHJKKJKKJHKKKHKJKKKKHFKJKKKJK?KKKKKKIJKKKDJKKKKIDKKKKKCKKK:KKK>KKKKKKKJKKKKKKEKKFJKKEJGKKKJ=HHKJKJKKKKKKIKKKJK5KKKKKJKKKFKKJKKHKKJKEKKKFKJKFKJJKJKKKK2KKKKJKKKKKKKKIKKKCKKIKKEKKKAKJIKKKJJKIIKJKAKJKKKJJKJKKIKIKKKKKK=KKKKKJKKKKHKKK?KKKJKKKFKCKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKIIKKKKKKKKKKJKCKKJGKHKKKKKKKKJKK @rCer/1237/25_1951_CCS ATGGGGGGAGCGGCCACCATCTTGGAACGGAGGCGGAGCAGGGCCGACTGGGAGCGACCGAGCGGGCCGCCGCCGCCGCCATGAACCCCGAATATGACTACCTGTTTAAGCTGCTTTTGATTGGCGACTCAGGCGTGGGCAAGTCATGCCTGCTCCTGCGGTTTGCTGATGACACGTACACAGAGAGCTACATCAGCACCATCGGGGTGGACTTCAAGATCCGAACCATCGAGCTGGATGGCAAAACTATCAAACTTCAGATCTGGGACACAGCGGGCCAGGAACGGTTCCGGACCATCACTTCAGCTACTACCGGGGGGCTCATGGCATCATCGTGGTGTATGACGTCACTGACCAGGAGTCCTATGCCAACGTGAAGCAGTGGCTGCAGGAGATTGACCGCTACGCCAGTGAGAACGTTAATAAGCTCCTGGTGGGCAACAAGAGCGACCTCACCACCAAGAAGGTGGTGGACAACACCACAGCCAAGGAGTTTGCGGACTCTCTGGGCATCCCCTTCTTGGAGACAAGTGCCAAGAACGCCACCAATGTCGAGCAGGCGTTCATGACCATGGCTGCCGAGATCAAAAAAGCGGATGGGGCCCGGAGCAGCCTCCGGGGGCGAGCGGCCCAATCTCAAGATCGACAGCACCCCTGTAAAGCCGGCTGGCGGTGGCTGTTGCTAGGAGGGGCACATGGAGTGGGACAGGAGGGGGCACCTTCTCCAGATGATGTCCCTGGGGGGTGCAGGAGGTGCCTCCCTCTCCCTCTCCTGGGGCATTTGAGTCTGTGGCTTTGGGGTGTCCTGGGCTCCCCATCTCCCTCTGGCCCATCTGCCTGCTGCCCTGAGCCCCAGTTCTGTCAAGAGTCCCTAAGGGAGGACACTCAGGACCTGTGGTCAGGCAGGGCAGGGGCCTGCTCTGCTGCTGCCTCTAGGTGACTTTCCAAGATGCCCCCTACACACCTTTCTTTGGAACGAGGGCTCTTCTGTCGGTCTCCCTTCCACCCCCATGTATGCTGCACTGGGTTTCTCTCCTTCCCCTTCTTCCTGCTCTCCTTCTGCCAAGAGCTGAGGTCTCCCGGCCTCTACTGCCCTGGCTGCAGTCAGTGCCCAGGGCCAGGAGAGTGGCCAGGGGATCCAGGACTGGGATCCAGGCCCTGGGCTGGACCTCAGGACAGGCATGGAGACCACAGGGGCCCAGCAGCCCACCCTTTCCTCTCCCACTGCCTCCTTTCCCCTCCCACACTCCCAGCTCGAGCCGTCCAGCTGCGGTGGGTCTGAGTATATCTAGGACGGGTGGGTGGGTAGCCGCACTGGGCTTGTGTCTTGAGCCTGGAGGGAGTCTGCTCCTGCCGCCCTCTGCCCTTCCAGAGACAGACCCGTGCGCTGCCTGCCCAGTGTGCCCCTTTGTCCCCACGTCAGGCAGAGGCGGAAGGCCCACTGTGCCAGAGGCTGGGCACCAGCCTTAACCTTCTGCTAGCACCTCCTCCCCTTCCCCGAGGCAGCACATCTGGCTCACTCTCCCCTGGGTCTCTGGAGCCCACCAGGAAGGCCCTCATCCCCTGCCGCTACTTCTCTGGGGAATATGGGTTCCATCCGGGGTTGGGGGCCTCTCTGCTCATCCACTCTGCACCCAGGATCCTAGTCCCCTGCCCTCTGGCACAGCTGCTTCCTGCAGGAAAGCAAGTCTTTGGTCTCCCTGAGCAGCCATGTCCCTCGTGCTGTCTCTTGCCTGTCCCACCTGTGCCCTGCCCTCCAGCTTGTATTTAAGTCCCTGGGCTGCCCCTTGGGGTGCCCCCCGCTCCCAGGTTCCCTCTGGTGTCATGTCAGGCATTTTGCAAGGAAAAGCCACTTGGGGAAAGATGGAAAAGGACAAAAAAATTAATAAATTTCCATTGGCCCTCGGGTGAGCTGAGGGTTTTTGC + 01,664969992748.11*+,(.,3793$,-788)--856(863924/1(4--/3341499753484940942;8387:;:857:2645419636254()//333597;868327999:6&/3:45595::3:7:4*7879:532/34-64.25-842456.688976489645.8507:::828648+44538-669-6*30,74/636598;90334744719)34:86635684599966;;;:7591(772$26095854,8.')01*190:81848:.77492;5:258*6(556288&28::9.28/6)666347666405253-30(7640233)-39966956324.158;52:5;564726138498:;:44886:/89:8399:9265187:92,61/58518:977:730/79.8742,51333.44.305747716:9.'*/0-*/.30878;:;6475483803/0,582459545*9234/660*5,+(10+/.53969/:86+42168984,839+624307518-10487:4516695:94/,./*12252/4294&(3433.6442372'798342+5:752960/88$&+54)02::7:+:89464:9826-71'73592(522689333573(4/.-2047;48;37586856:74:534-45:2.6;6)68::9-896;488,33881+52.32259:6;9:93399:5864794.522*4541101563072707+*0,2859:3;?>>=>==.<;:713;=95<;<8:;8:><=>399:6;2998)47:9(=;8>=<>4?56:86>&81459=;1=4<7::062:769,5634/28=6=93=?<7=;4969660::13>892573655=8=9;20>7><9;881;:77/=<6)<97847=:689==<;9-7-1879??3;2:;<76&87:;51:;873=,:865999=0):=;=<2779<3=096/94==4:%5+*489042334596,7;0:;5:;,:60,/4266>259>5=;=?9>=337-9=<8+<-83:;;7=+365=8%9:4:3>8>45==60236<>>8<86>;::>0:,><719;7?<7;01.432>:;='57<>;<;29=:%74<>64;78%91;?:8;?=><=:;:>><79;;;=?=>71=8;68>:8;0:==5<>4841839=9177/64(<<=<$;<7:99.0067::?4==>=,:=:8/9;09::;;9;>29:?:>;=:4857=;?='48<;:99;;).6:>:12:79<<==46687>=99;5?<9498)<:.9=)47652;=::9;,:?<2====:82:;9;=><78;<7<>>=+8-9;A*:76436<<3@?@5C<3=2;4<674>?@>B:=57/506B=9==09,44378;6:65<;;?;79?:?;=>:6>>>>>:487191$/9-)3'88:=>8;<:=65:7>:=4::>>>4;861;>?=4:?;286;:>5<.997788288=<8*>:>=6><5=<>:0>:=:;>6;4=93>=?:>9>2?>919.<=>>0:==756466<6.,59;<:=>85(4579?9>3;=8>5)<449:77>;>68=37:=;>><6:=:?:=<<6838=:937;2<*<<->97>;??>9<7:8:2?;89;5?=;9:><:=77>4:7:=,:2869??<;=6=699=?><9;=>97=:>8=69<4><3<;=0?882=<322,:>>;?3>>>96%;:8049:7/9<;,<9;'9914004458=::=98.399:7>?;:>>?:?'798:5::>:?&89;8?==>:;=/;7=69593>>:>>;8:5==0>91;91=9;94<'<9:89=?:=:<9;<>6>:.>=??:: @rCer/1238/2717_60_CCS ATGGGGGCGCTCCTGGGCGGGGGATGTTGTGATGGAGAAGCCGCGGCGGAGCCCGAACCCCGCAGCCTGAGCCACCTTCGTCATCTGGGCCGGGGCCTCGCCGCGCAGGAGCTGCCAAGGCCATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACGGAGGCCCCACACTGAGCCTACCCCTGCCTCTGCACGCTGCCCATAACCAGCTACTCAACGCCAAGCTGCAGGCCACAGCTGTGGGACCCAAGGACCTGCGTAGCGCCATGGGGGAGGGTGGTGGGCCTGAACCAGGCCCTGCCAATGCCAAGTGGCTAAAAGAGGGCCAGAACCAACTCCGGCGGGCCGCCACGGCCCACCGTGACCAGAACCGCAATGTGACCTTGACCTTGGCGGAGGAGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCAAAGGCCTGATACACCTGTACTCTGAGCTGGAGCTCTCAGCCCACAACGCGGCCAACCGAGGCCTACGAGGACCTGGCCTGATCATCAGCACTCAAGAGCAGGGGCCAGATGAGGGAGAGGAGAAGGCGGCAGGGGAGGCTGAGGAGGAGGAGGAGGAGGATGATGATGAAGAGGAGGAGGAGGACTTATCTTCTCCCCCAGGGCTGCCTGAGACCCTGGAGAGTGTGGAGGCCCCTCCCAGGCCCCAAGCCCTTACAGATGGCCCCCGGGAACACAGCAAGAGTGCCAGCCTGCTGTTTGGCATGCGGAACAGTGCAGCCAGTGACGAGGACTCAAGCTGGGCTACCTTATCCCAGGGCAGCCCCTCCTATGGCTCCCCAGAGGACACAGATTCCTTCTGGAACCCTAACGCCTTCGAGACGGATTCCGACCTGCCGGCTGGATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCCAACAGGGACCACCCAGTGGGAACCCCCGGCCGGGCCTCCCCCTCACAAGGGAGCAGCCCCCAAGAGGAGTCCCAGCTCACCTGGACAGGTTTTTGCTCACGGAGAAGGCTTTGAGGATGGAGAGTTTTGGAAGGATGAACCCAGTGATGAGGCCCCAATGGAGCTGGGACTGAAGGAACCTGAGGAGGGGACATTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCATTGCCCCAAGAGGAGGAGAAGCTACCCCCACGGAATACCAACCCAGGATAAAGTGTTTCGCCGTGCGATCCCTAGGCTGGGTAGAGATGACCGAGGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTGCATCCGTCAGCTCTCTTACCACAAAAAACAACCTGCATGACCCCATGTCTGGGGGCTGGGGGAAGGAAAGGATCTGCTACTACAGCTGGAGGACGAGACGCTAAAGCTAGTGGAGCCACAGAGCCAGGCACTGCTGCACGCCCAACCCATCATCAGCATCCGTGTGTGGGGCGTTGGGCGGGACAGTGGAAGAGAGAGGGACTTTGCCTACGTAGCTCGTGATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCCGCCAAGAACATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCCGAACGGCGTAATGCCCGCTGCTTGGTGAATGGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCCTTTCCAAGTGGAATTCCCAGCGCCTAAGAATGAGTTGGTCCAGAAGTTCCAAGTCTATTACCTGGGGAATGTACCTGTTGCTAAACCTGTTGGGGTAGATGTGATTAATGGGCCCTCGAGTCAGTCCTGTCCTCCAGCAGCCGTGAGCAGTGGACCCCAAGTCATGTCAGTGTGGCTCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGGTGCGTTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCCACACATTTGCATTCATCATGGCTGCCGGCCCAGCCTCCTTCTGCTGCCACATGTTTTGGCGCGAGCCCAATGCTGCTAGCCTCTCAGAGGCTGTGCAGGCTGCGTGCATGCTTCGCTACCAGAAGTGTCTGGATGCCCGTTCCCAGGCCTCCACTTCCTGCCTCCCAGCACCCCCTGCTGAGTCCGTGGCACGGCGTGTAGGGTGGACTGTCCGCAGGGGTGTTCAGTCGCTGTGGGGCTCCCTGAAGCCCAAACGGCTGGGGACCCATACCCCATGAAGAAGCCTCTGCCTTCCCTCCACCTGCTTGTGTCGGGCCCCAGGGAACTACAGGGTGTGGGTCAGGTAGGGGTCTAGAGGCTATTCCTAGGCCTTAGGCCTCCCAAATATGCCCCTCCCCAGTAGCTAGGGTTCCCTGCCTAGGAGCTGGGGAGGGAGAGATCTAATCCCTTCAAGGAAGTCATAACACTGGTGTGGTAACAAGAGGAGCAGGAAGCAAGGCCAGCCCTGGCTCTCCATCCCCATGTGTTTCAGGTGGAACAGGAGGAACTGGCCCAGGCCAGGCCTCATACTCCTGGGACCCAGCAGGGGCAGGAGGAAGGGACTGGTCCAGGCATGGGTCCCTTCCCTTTGCTCCGTGGGCACCTCTACTGTATTGATATCACTAATAAAGTCTGTCTGCACT + <88<:=+78=<=9==><9==>?196>74:9689?<<8=9<<8:2989?=>>;8+<=87<:486<7;8=1-988399=2>>688)7>??4?7;:;,8.5:=?<:.;=>?=>;>9==9>/=8=<<==3#7;==:5+4><.7777418=3>674?7?:<;7?>==?=;39*9>7<>:/79+:59-=8->7;95?9::8;;+:9?:9;:868776;479*<4=6==9:;28<2<=3;7:;<+;88482=9>983549<=;441'41*91541969<-0/1-92540399762604069967:457:8;194;99:8517734+98<6:-77168446/0*,5<3866>=9;98<:86.8359:664:<5:=?9=;39>6>>:;>28:=:;5=<<962;9.=7<6<3<;;<:6:832988<5=71<:8;;=3<:>;>;6:989:<4<=:===;=;285<79689<===;.113,3<;=<=9=9<<>=;<>9<:<8;?;2=9=<097;:9=9>=9>;=:7==>7>>9976:>,=98=;+=<;>658332:>;>>98><85?::2>=:=>>:9=:?=>=72:481/0;1<2:?===9==8;>?<>85/92:;63<<96::;:4=49<>*=;===9;=569>>=>=51>6==78388918=5=><219<7581=5:3<,9=:7?;948439=8;84<)8=9:/;8:>?;<==::<8<538>:<:78:??9:70709>>9==;>;3;;9::;8;>7<9;8>9;4:??3>=0:5;817:<19=<5;==;?:49=<<8.?8>>??=<595<77:-87;9?>=8:453;:?851.48$69=99,6=;777831=5?><;<+:>>+:.=.:3:97155:87766;88;76816-685:544;9:7;58;8?7:=9::;?:=<<:??=8;7:??:;><;81<0;:;<*>:?>?*-<-6699=&;8<;=2:>->;?>9;;??9?77;<5>6<=>7:89;:<<<*1>?:==?<:7>88=>*>9?>?==9:87:>>>8>>=9>>>+;1,;<>=39<;)9;97?>?::+<=?<=86<=>>69=<859<>7?8>?69;<=>><5>998878??3669;?=??<:<<>/<6=>?>><7/8:6>>>:==>:/2::5?552=77-9;68:$099>7<>;<=/>:55:>6;??<>=9>:79/=<682)58618>=<2<:?5::;=6:1::>??:>?58/<>8489<<==;>9;8>>?:>?=>9<96:?=?=<921898;=6>:98<9:;<>87=.<9>;=>>=:>??293>::>???;7<8;95;&<8=:=<:?:7:6:::6:><;>=>;=65<91=>=585>;79=>*>:9/3=9;>5=899<<14=8>?9;??=?>7=<9767;+8'7:7<8658=><590?>><8;89<==198?9<=58>:09:6=;<2=2>=>>>==<517<=6;?>=39;:=<8$;:=156:,889<<>=6<=?;>;;>?49<>9)9=>;:8<2889;:<4><<24<<:>?;>96>26:9>==:=>59><7;;7<:<>>><>;=5>>6=6>>6799?7=99>9>?2;;:9,>>?=8><<:=<8<(54:;=:8=8/<>=?;7=447637;>;==/=>>200>7==;6>>=>87<1:;6><68>9?>=?<>=>9=<2?;<1594;/=7>6==5=?;=:9><=;6568.65677*<4:9<8>;?4;=;-)88;=>9;2:56$7?8===>=<2742<6>>863675:997>?898::=?;=6;:7:9>+<97068799>==2:<=628:8>=>93>;975.853;:?9=,4>9:5487>=<>=>706:><>;;83<=>=>;;>=>/::>>??377=79?>?=?:9>.=457??8??>?:=69>>=8858;=<=<>==8=;:<66=:>==>:><=;1=8>9>?<:16==977588<7/37;9'7'*5:<69:8,<5=>>;=678915>>>><=><=>9>783<6;>?=:966669/88<798:8<=<3;9:8<7146=>>5:<2??7=?9?:7=/=9<=?::<<14<;<7:><3>>==?>=76:>:?984<804>;778=;;??:=/<55<><7=>?:>947<==>9=>>;6:>?:78>?7><=98:;498:>9=9;;2<=;?:??<;?>>?>?:862=?;<=0=?;>,>>==8<3185;5>?=2=7>><:76:97970725#5=5<:7<=2>>5778>?=<=>=8;=98/58988577=2:>;3=?:>>693>>>??2597;6:<=9739<1;3;98=6:<706;;=3>>;6?=;;+?=8=4962:9?56462;4<3>>?>?;;=78??67;87-5-<89:523%;7646876428::9:87;4:+9786;>8?99<)1=;4:4>>?:77=:=>;?82=698<8<2>?:692782<;828=:688:;8=>?=:>7999;?:?;.;<>85*45510<;12/1==>;?>7<=> @rCer/1239/25_2661_CCS ATGGGGGCCCCGCCCCGGCTCGGGCGGCCGGAGGACCCGGAGCTAAGGCTCCCGAGCCCGCGGCGGCGGTGGGTACGATGTGGTTCTTTGCTCGGGACCCGGTCCGGGACTTTCCGTTCGAGCTCATCCCGGAGCCCCCAGAGGGCGGCCCGCCCGGCCCTGGGCCCTGCACCGTGGCCGCAAGAAGGCCACAGGCTGTCCGTGTCCATCTTCGTCTATGATGTGAAGCCTGGCGCGGAAGAGCAGACCCAGGTGGCCAAAGCTGCTTTCAAGCGCCTCAAAACTCTACGGCATCCCAACATCCTGGCTTACATCGATGGACTGGAGACAGAAAAATGTCTCCACGTCGTGACAGAGGCTGTGACTCCGTTGGGAATATACCTCAAGGCGAGAGTGGAGGCTGGTGGCCTGAAGGAGCTGGAGATCTCCTGGGGCTACACCAGATTGTGAAAGCCCTCAGCTTCCTGGTCAACGACTGCAGCTCATCCACAACAATGTCTGCATGGCCGCCGTGTTCGTGGACCGAGCTGGCGAGTGGAAGCTTGGGGGCCTGGACTACATGTATTCAGCCCAGGGCAACGGTGGGGGACCTCCCCGCAAGGGGATCCCCGAGCTTGAGCAGTATGACCCCCCGGAGTTGGCTGACAGCAGTGGCAGAGTGGTCAGAAGAGAAGTGGTCAGCAGACATGTGGCGCTTGGGCTGCCTCATCTGGGAAGTCTTCAATGGGCCCCTACCTCGGGCAGCAGCCCTACGCAACCCTGGGAAGATCCCCAAATCATAGTACCCCATTACTGTGAGCTGGTGGGAGCGAACCCCAAGGTGCGTCCCAACCCGGCCCGCTTCCTGCAGAACTGCCGGGCACCTGGTGGCTTCATGAGCAACCGCTTTGTAGAGACCAACCTCTTCCTGGAGGAGATTCAGATCAAAGAGCCAGCCGAGAAGCAAAAGTTCTTCCAGGAGCTGAGCAAGAGCCTGGATGCGTTCCCTGAGGATTTCTGTCGGCACAAGGTGCTGCCCCAGCTGCTGACCGCCTTCGAGTTCGGCAATGCTGGGGCCGTTGTCCTCACGCCCCTCTTCAAGGTGGGCAAGTTCCTGAGCGCTGAGGAATATCAAGCAGAAGATCATCCCTGTGGTGGTCAAGATGTTCTCATCTACTGACCGGGCCATGCGCATCCGCCTCCTGCAGCAGATGGAGCAGTTCATCCAGTACCTTGATGAGCCAACGGTCAACACACCAGATCTTCCCCCACGTCGTACATGGCTTTCTGGACACCAACCCTGCCATCCGGGAGCAGACGGTCAAGTCCATGCTGCTTCTGGCCCCGAAGCTGAAACGAGGCCAACCTCAATGTGGAGCTGATGAAGCACTTTGCACGGCTACAGGCCAAGGATGAACAGGGTCCCATCCGCTGCAACACCACGGTCTGCCTGGGCAAAATCGGCTCATACCTCAGTGCCAGCACCAGACACAGGGTCCTTACTTCCGCCTTCAGCCGAGCCACTAAGGACCCGTTTGCACCGTCCCGGGTTGCGGGTGTCCTGGGCTTTGCTGCCACCCACAATCTCTACTCAATGAATGACTGTGCCCACAAGATCCTGCCTGTGCTCTGCGGTCTCACTGTAGATCCTGAGAAATCTGTGCGGGACCAGGCCTTCAAGGCCATTCGGAGCTTCCTGTCCAAACTGGAGTCTGTGTCGGAGGACCCGACCCAGCTGGAGGAAGTGGAGAAGGATGTCCATGCAGCCTCCAGCCCTGGCATGGGAGGAGCCGCAGCCAGCTGGGCAGGCTGGGCCGTGACCGGGGTCTCCTCACTCACCTCCAAGCTGATCCGTGTGCACCCCACCACTGCCCCCGCAGAGACCAACATTCCCCAAAGACCCACACCTGAAGGAGTTCCTGCCCCGCTCCCACCCCTGTTCCTGCCACCCCTACAACCTCAGGCCACTGGGAGACGCAGGAAGAGGACAAGGACACAGCAGAGGACAGCAGCGCTGCTGACAGATGGGACGACGAAGACTGGGGCAGCCTGGAGCAGGAGGCTGAGTCCGTGCTGGCCCAGCAGGATGACTGGAGCACTGGGGGCCAAGTGAGCCATGCTAGTCAGGTTAGCAACTCCGACCACAAACCCTCCAAATCCCCAGAGTCCGACTGGAGCAGCTGGGAAGCTGAGGGCTCCTGGGAACAGGGCTGGCAGGAGCCAAGCTCCCAGGAGCCACCTCTCGAGGGTACGCGGCTGGCCAGCGAGTATAACTGGGGTGGCCCAGAGTCCAGCGACAAGGGTGACCCCTTCGCTACCCTGTCTGCACGTCCCAGCACCCAGCCTAGCCGGACTCGTGGGGTGAGGACAACTGGGAGGGCCTGGAGACGGAAAGTCGACATGCCAAGGCTGAGCTGGCCCGGAAGAAGCGCGAGGAGCGGCGGCGGGAGATGGAAGCCAAACGCGCCGAGAGGAAGGCGGCCAAGGGCCCCATGAAGCTGGGAGCCCGGAAGCTGGACTGAACCGTGCGGTGGCGCTTCCGGCCGCGGAGAGCCCGCCCCACAGATGTATTTATTGTACAAACCATGTGAGCCGGCCGGCCCGGCCAGGCCATCTCACGTGTACAATAATCAGAGCCACAATAAATTCTATTTCAC + .2)4-(2(1433/56516335.630,526*3314-&0235251235064.131514)033656202++,14526535650.45160//,.1/1.2-'&00-+216&2352324+132610454664.+45+.(305652/3./515440354163,62061/65.562031*0,1*5440-.60*4365622)/45443$42320/661656044625452141.153*0.2666616/63+3645.(1220/,.1(3142/2200.341)232.14(-'101/,001-/0-33-12/1*1312/262565046521'1040155/41252,3.46320,25446654441+400*0531-43564143.6030'4..022236041662155/3440.544)2206-21**3).45662223213,124$422-/5341264146*(0*3.22643245215/5403).-45.2/11111'0/1*.24403/32326435-03.1/15-4.,*02660.41436.,/024453564:18855;/6:::9:04368:::81599+20861675,598'555;0)57753-66)55558-3.47812*/20+)(./24+423(2.378+:88734;895:96::57:715-56/5425(98093475&0456590354:46::58::58531:6.12;-773351703152586:'679.3;6896)/-.:85..3712.866755-17::448562:1964.777;261*997.0241-#030+%/35513498.20.*4031.,02188:321/98.948/4795096094663948976+:38758:6099036;/7:3576/%35379,/'--3)55,95752/858855466*809.52(,6254)/0487795;5:7:74696::557::122,75:68'5568:94-4+64(/729577:7,51461;87;78772281444768;:6:58:895*8364.75656:455;6:+7919:::98457998'5:10983;5,47456*950*7699:76;:5098#1/155+89/59:4.6::6;6.7588984924.2/,65966)2&695695;94308/.6744979766:738/(687;6:2,407659817:59848-4+545898;65950;68/,8512-:4:-1:7:7;976/659224625768788'37:8+74'-043+#(11036919&.3134+67:39822437:588678755::;5:3/85:4:56948;;953-1.315-+7;256516::::6677784)3369+9,168-97776+1-63;:98:6:455+9222:8(.74468391873686(77/81737/21617*.).68,*/3/,30785:7835:0945-41554/4:5(222968+55-5756,,01304655.755(771.54978&3::9/37759:98:76156-57;725.64:897::68906.2;84(47753299:.7208:8;957691066:9/9892695858177/6/%12/7:83:2769365:745:86955534978649::5:45697947497552)7455769987/99.:6:63319;:78-7887;5/.4.6953599+845/3381415*1)114643-*2296863;609::6788989618/.922408685.4)41495067.448-:1884*1551,59637:8669943778;3,3,+0025--1;6866598676,678..7757;;4:69586948053277848.5857363991958:727:;89::77530399:;5366.:558308,/2478+8996;*65.)9:37,42523*/36-45:4607,8(2)18($.6*673*5563779:;88251'5/13.526/21:6&1+5/353444528764*1-3493701/96:246551643546-7390'14647916:69402(5::453495,94.6657778/0591.*/6::5-'+275781-233059:89-6668/519788:1829016992,33,323.9/2387(41-.-,0342::369879998::;6:27:4/971:99250546*/577:7:56;:7821;84:8:9:4:7*975329&45451991:4/9:5&88986744452464+7578-881938*19626680666175/2+,*(+21877974483434718560478228(132325:47*79::76;599::3.696667268:.2-144257777:6,66265642671497/24:6::779:969626:82846+850/9:6/8659:132-2:.:555334848697-7-788459612/28,95/549725945989141747;28585;:3944+7-341.,:89926./57:44:39-5449:9/;399'651-492:::4'659:4678;89908398842+/49::66340.6798/5&6/21486-868954799*:::838::689954591:::87-98,43+64711*6,75;67*89577;:8;8;:36/4::991987%0.396966,3495969:46328:89/98976 @rCer/1240/1912_62_CCS ACGGGGCAGTCTCTGTGCGTTTGAAGCCGGAGACCGCGGCGGCCTCAGCGAGGACCCTTCGCCCCGGAGCCGCCGGCCGGGACCGCAGCCTCTGCCGCAGCGCCCCCACCACCTGTCCCCTCCCCCGCCGCCTCCGCCGGAGCCGCCTCGCGCACTCTGGGGTATGGCCGTCAATGTGTACTCCACATCTGTGACCAGTGAAAATCTGAGTCGCCATGATATGCTTGCATGGGTCAACGACTCCCTGCACCTCAACTATACCAAGATAGAACAGCTCTGTTCAGGGGCAGCCTACTGCCAGTTCATGGACATGCTCTTCCCTGGCTGTGTGCACTTGAGGAAAGTGAAGTTCCAGGCCAAACTAGAGCATGAATACATCCACAACTTCAAGGTGCTGCAAGCAGCTTTCAAGAAGATGGGTGTTGACAAAATCATTCCTGTAGAGAAATTAGTGAAAGGAAAATTCCAAGATAATTTTGAGTTTATTCAGTGGTTTAAGAAATTCTTTGACGCAAACTATGATGGAAAGGATTACAACCCTCTGCTGGCGCGGCAGGGCCAGGACGTAGCGCCACCTCCTAACCCAGGTGATCAGATCTTCAACAAATCCAAGAAACTCATTGGCACAGCAGTTCCACAGAGGACGTCCCCACAGGCCAAAAAACATGCAGACCTCTGGCCGGCTGAGCAACGTGGCCCCCCCCTGCATTCTCCGGAAGAATCCTCCATCAGCCCGAAATGGTGGCCATGAGACTGATGCCCAAATTCTTGAACTCAACCAACAGCTGGTGGACTTGAAGCTGACAGTGGATGGGCTGGAGAAGGAACGTGACTTCTACTTCAGCAAACTTCGTGACATCGAGCTCATCTGCCAGGAGCATGAAAGTGAAAACAGCCCTGTTATCTCAGGCATCATTGGCATCCTCTATGCAACGGAGGAAGGATTCGCACCCCCTGAGGACGATGAGATTGAAGAGCATCAACAAGAAGACCAGGACGAATACTGAGGGCGGCCGCAGCCCTGGCTGACTGCACGGCTTCCCCATGCCTCCCTCCCTGCTCCACTCCCACATTATAGTCCTTTCCTAACACGGTCGGCCGGGTGCTTTGTGTCAGTGCCGCAGCACTGGGGAGCCAGACGAGCGGGCTTGGGGGCATGGGGCCGGAAAGCAGGCAGAAGCCCGTCCTGGGTGGCGCTGGCCCAGTTGGCGGGACCCCTGTCCACACCCACCCTATTTATTTCTGTTGTCTCTCTGTTGTGTCACCCAACATTTCCCAGGGTGCTGCTGCCACCCGCCCCAGCCAGCCACCTGCTCCCGACAGCTAGCAGCTGTGTATTTGACAAAGTCATTGGTATATTTTTACTTACTGGATTCTCCTTGCACTTTACCTGTTCTTTTCCAGAGCTGACAGCACGGGCTCGGGCAGTGTGCCTGGCTTGGCTTCCCTTCCCCATGGCTGGGGGCTGGGGCTGGACTCACCCATTCTAATTTATTTTGTCTTTTGGCTTCTCAGTAACTGAGGGGAAGGCTGATGTCAGGAGAGGGAGAGGGGGCTGAGGAGGTAGTGCCGTAGGCCCAGGGGGTCAGGGAGAGGGAGGGGGCATGTGAGGGATGGAAATGACCTCCTGGCACCAGGCTCACCCACCCAAGGCCCCCTGCCCCAGCACCGAAGCCCACTGCTGCCCTGAGGCCCCCAGCCACTCCCTCCAGCAGCCTGGTTCACCACACAGACTCTGCCTGGACCCCATTGTCTGTCTGCTTCCCACCCACCCTGCCCACCCCCTGCCCCTCAGGCACCAGCCTGCATATGTGTTCACTTTTATTTAAATAAACTTGTGCGGTAAAAGC + &%=DC%BCFAHGE>CDFEHIK&HJIGK?GIGBJJ@8=KGJKIHD6KJJK@FGHKK@J@BHIJI?/G9=F;GEBEJIGGFIJI@HIKEIHFHAIFCFDE?IIGJKKKDGKDJIJGGJJADJIIKJJIHKJJHIKKHFJJH=D7?;7IJ/GJEKI=JBD'6DJGCKII>IGG?IKIKIJKIIJIJFIDEKI3DHGKIDIIEHJEDJK8JJIKJJDJKGIFJJFFI=GI5DGKJGFJJKKKEKKJJJK>J9AGF:IJ>?KJKKKJDKBHI)&%HKGG@F8IKB:G?JA=D@FIFJ>I@FF;H5FD@CHB@8CICB'BGCBGEGJ?HA?;EDDGCFFC>FIHH@DJ8;BH3DJFB0DDF1BDG;CD?HD9HEHF7HG8I@DJDIH>E@EGF<:?H*HJHIFA=AIHIEECFGEHIFHFBIE@IA?BEG?HIIAICDH>A*BABA:-HEC;A<@AHCC?FBHEAF7IEHC;@=IGBC1=FIFHJC?HCG?H@FJBFHHAECEH,EC?H:,DDICHGFCIFGDB5AHECGGG2HJHIICAAF<;FFBA<=;C7FDC?IHBGG9F=HGHIIIBGJHIIDEFCIFHCIEHHHGJI@FHGE2@FI@IJCAD@ABC>EDDGF:DEGD8A:9H?IEHIEAG@3D@G2EJBFIFEE>HJBHEIF@=AHI6GGAG;GFIJHGBCHEHEEHICDB@)ADGBBBCECAE?AB@2?F@AB@?@8<8CC;DED>3CABE&FD??DCAFDDB8ACC@FAD>AAFAFDGCE@FFBB8>DB?B?*:DBBB=DEBEA8;?CCE&EGEFEA2AA=0DGBAE:EDG?2AC=><<&<>3?E8CED7A<>A0B:;A&>AC?@59?>0C=>,125308?CADCD,?C6BB<@B?@:EBD;CE2DCA*%DD@A?FDC@AAB>8@A7B@BCFCF4BA>CDB98>A.DB?3KKKKKKJKKKKKGKKKKAKKKKKKKKDKKKKKKKKA+JKKKKKK+KKKKKKKKKKKKKIKKKKK?KKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKK*JKKKKK$KKKKKKK:KKKKKKHKKKJKKKK;KJKKKKJKKKEKKKGKJKJKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKGKKKJIKKJKKKIKJJKKIKKKKKKKKJHKKKKKKKGJKKKIKGKKKKAKKGKKKKKKKKHKKKIKKKKKKKJKKKKDKKKK=KKKKKKKKKKKKKKKKKKAKKKKK9KKKKKK?KKKKKKKKKAKKKKKIKKK.KKKKKKKKKKKKKKKKKKKEKKKKKHKKKKKKKKKKJ*KKKKKKKKKKKKKKKKKKKKKKKKKKAKK?KKKKKKKJKKKKKKKKJEKKJ&HKKKKJKJKKKKKKKK* @rCer/1243/1843_88_CCS ATGGGGAGGTGGCTGGAGCTGAGTATGACAGCACCAAGCAGAAGACAGAGTTTGTGGTGGACAATGGACTCAACCCTGTATGGCCGGCCAAGCCCTTCCACTTCCAGATCAGTAACCCTGAATTTGCCTTTCTGCGCTTTGTGGTGTATGAGGAAGACATGTTTAGTGACCAGAATTTCCTGGCTCAGGCTACTTTCCCGGTAAAAGGCCTGAAGACAGGATACAGAGCAGTGCCTTTGAAGAACAACTACAGTGAGGACCTGGAGTTGGCCTCCCTGCTGATCAAGATTGACATTTTCCCTGCCAAGCAGGAGAATGGTGACCTCAGTCCCTTCAGTGGTACGTCCCTGCGGGAGCGGGGCTCAGATGCCTCAGGCCAGCTGTTTCACGGCCGAGCCCGGGAAGGCTCCTTTGAATCCCGCTACCAGCAGCCATTTTGAGGACTTCCGCGTCTCCCAGGAGCATCTTGCAGACCATTTTGACAGTCGAGAACGAAGGGCCCCAAGAAGGACTCGGGTCAATGGAGACAACCGCCTCTAGTTGTACCCTAGCCTCGTTGGAGAGCAGCAGGTGCTGTGCGCCTTGTAGAATGCCGCGAACTGGGTTCTTTGGAAGCAGCCCCCTGTGGCGGCCTTCTGGGTTTCGCAGCCTGGAGCCTGGATTCCAGCAGTGAATGCTAGACAGAAACCAAGCCATTAATGAGATGTATTACTGTTTTGGGCCTCCATGTCCCAGCTCTGGATGAAGGCAAAAACTGTACTGTGTTTCGCATTAAGCACACACATCTGGCCCTGACTTCTGGAGATGGATCCTTCCATCTTGTGGGGCCAGGACCATGGCCGAAGCCCCTTGGAGAGAGAGGCTGCCTCAGCCAGTGGCACAGGAGACTCCAAGGAGCTACTGACATTCCTAAGAGTGGAGGAGGAGGAGGAGCCTTGCTGGGCCAGGGAAACAAAGTTTACATTGTCCTGTAGCTTTAAAACCACAGCTGGGCAGGGTGAGAGGCTAGATGCCCCTGCAGTTTGGCCCTGGAGCCAGGGTAGAGGAATGTAGGGCCTGCATGGAGAAGGGTTCTGCCCTGCCTGAGGAGGAGGACACAGCACAAGGGCACATTGCCCATGGCTGGGAACATGACCCAGCCTGAAAGATACAGGGGATCATGTTAAAAATAGCAGTATTATTTTTCTTCTCAATGGTATTGTAACTAAGTTATTTACTCCTCCTGCTCCTCACCCTTGTAGGGAAACCTTGGAGTAGAGCCTTGGAGAGGAGAGTGGCAGGTGGGCTGCCTGCTGTGTTAAGAGGGCTTAGTTTGTGATGTTAAAGCACTGTCAGGAAATGGGGGGCGGGGGTGGGGGGAAGAGAAGAAATAGCAGAGCCTATTTTGGTGAGGTTGTTTTTAAGTCGAAGACTCAATATGCTTTCCCTGAGGAATGAAAAAGCGATTGAGGAGTTGCCTGCCTCCTGGGTGGGTGGAGTACAGGCAGTTGGGTGCTGAATGAAGCTGCCATCCTTATTGCAGCTTCTAACCGGTAAAAAAGATCCAGGGATGGAGATGGGAAGGTTAAAAAGGCAGCCCGCACCTCAGGACAGAGGCCGGGGTCCAGGCCCGTGGGCGCAAAGGTGCCTCATAGCATAGCCAGCATTCAGCACACACAAACCTACTGCCCACATTTGGGCTCAGGGTTGGCCATTTGCTAGTTCTGCTGCCCTCTTAAGATCTGACTGCCAAATAAATCATCCTCATGTCCTTTT + /:<8;.@=>:@75:;:?<@6?4;>@;=@>B@:5732:>8269;6:>;:?B;?;C@6>=:9@B:BA?=@5?:B>A;>593;@<5@BA;>C76@@1?=4;6@?@@CA3A8?:@>;6?BBB9>66@;;68:&8@>6AA7<<@7@59=/:<'@68@:>7C;416=C7BAAE<:;?DGD?>@?AC?DC?EDAD?=AA;B?@?AB@DD8<HFFJFGD@BHC0>D8GIE;H?AE@C9G@B>?AE=?>IBAB=GDGGBFEGC@FHCGIIGHDC6@FAE;45=D@EH?C;9GBCBFI>AHHFIHGGHEEGIHGEHAI=J2E?=CF=HE3FGIICEHCFF1CEEDHI?GA>:H@?BC?EG=B>?C&FDHE@EG9C:FD:B:6AI3CC68HGC@EE8DIBG@AE6@ED8?FDCD>@GBHG8GCD9EF;E@B8?/>G;4>FGIHI?BA=C>E8DEJH>DI?CDGH:IHHEFHCBFD:G;G?CG1;IEE=DIDD:EG8?EFHBJIAF;E.GAFFGEFCC/?FIEHB9F:A@;AC>BD@FF>EDIF@FHGB9=E8F@>FC@CHFI?4=FE>EFC9/;DGAE7=EGFE/?CF;'?BCA5FG2IIDGECJHEC>AIC>=CCC?E;EE:HE7FBFG*KJKJKIKBIFHID4KGEGJDDBGA@BH>EDI=2KICIJ=KIJFHKDFH>GKFDG5J>E@KHF@DEIAJKDB?>JHFKJIIIHIK?>DJEHACFABIKIIHIBBCJHHDGG>J6IKGJBIJEE9A<==+=AA;>>:>+=-<;3<8?D::FGGCDCEFCBD6GG@GAGHEIDDBH???$@FIA@@+6JHEF%=C:CC@2G7DDCH2HJIFG:ACF6EF@GIJHKEE5GI=F8DGFF=:IHD7CIF?IKIJKGHBF?G3=F:HAFGJE=GDECDA>@=EEG=F<>FE8AE?FGEDA:E?DJ>HIDIH:ICFFC>DCGDFHB;;G@FFG:?EGAFI@D?@?AFACC)=9>9@DCD;=EBB9CF=DAF.CA?@FG@;9C?96CB:5B7FHDFE8?BB6CDEEEGI:EIIDHJJCAJK@FKKIHJ?JCEKJKHICH::DKKIKIKKFBEJG;CC+GIKJFGIK;IE@KGAKKKKJKJJJJHKE=KKKHHHKBK=BFH5JJFJJKKGJJKFKHKKJJJKDKKKKKKKKKKKKKKFJJKKKJGGJJKKBKKKJGJJ@KJKKGKBKKKKKCKK?KJIJKK2KKDEEKJJGDEHKIEKKHKKKJJIHJIGJKKKHKHKJKHKKKGKKGEJKA/@EDICKGDD@GEIJJGDG=HKKKKKK?K=1A@C:AIA5EI?KEKKEKKK8IJIIGHJEIKH7JI4IGKKK@DFJJECJKKJKJHIJKKKKJ6KKJKCKKIKKHKDKHKJKKKKKKJKKKJAIJKKKKKKKIKKKKKKKKKK8IIKKKKAJKGJKKJKKKKKKIKKK?KKKKKEIKF7FG@KKKHKHJFCJ@KKKKIKAKKKKKGJKKJDJKKKJKKJKCJKEKKKJKKJKKCKKKJKKJJKKKKKKKJBKEKKKKJJKCKKKKKKKKKKKKKKJKKKKKKBKKKKKKIKKGKKKKCKKKKKKKKK=KJKKKKKHKKKJKCKKKKKJKJKBKG?>9A;IBDFCHBADJK>KKHKKKKKKJIAJ)IJKHKJJFKKKCKHKKKKKKBIKJJKKJKKDJKKHHKIIIKKFKJIHJKJJ/KKKIKHAKJJKJKKKKKJIJKKIAJJJKKJJKKBIAKJCJKKGKKKJE-KKJKKFHKF9KJFKJKKKKKKFKJKKKKIHAJKIKIJKIKKKKIAK9KFKKKKKKJIGJKDKKIKJCJIGJKKHKBKKIIKKKKJJKKIIG9DI9HJIIBGHJHEKIJJFHJHIA87.G;JKKKKGKDKKIBKKKKKKKJKKKIKIIGHKKGIJGEKKKKKKKKJDGKBKFEBIJJ:HJKJKI?HKBKKHJJKHEIAE;8G@7IHJJ=IFK2GJKGKIGKHFG?HKKIJEIIGKKKJGKIKKEEK?KKJJKKK@GKIEKEKKKK@H7)KJKJKKKG@KIJ=5JKKJKJDJKKKJJKKKDJJJ2FGKKKKKGKCKKJKKJJKKFKKK@KJ8KK4KHIH?KKJJJKEKIHJJGCFIKKKKJIIKFJJ%EK>IKKKKIKJJKDIK @rCer/1248/25_1863_CCS CATGGAGTTGGCCCGGGAGGAAAGATGGTGCTGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATTCGAGAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACAGCTGGTGAAGGCAGACAGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACGATCGGAGAGAAAATGAGAAAAAAGAGCCAGTGGAAGATGATGAGTCTGTCCCAGAGAACGTGTTGAATTTCGATGACCTTACTGCAGACGCTTTAGTTAACCTGAAAGTCTCACAAATCAAAAAGTCCGACTCCTCATTGACGAAGCCATCCTGAAGTGTGACGCAGAGCGGATAAAGCTGGAAGCAGAGCGATTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTGCCCATCAGTAACGATGAGGATGCGGACAACAAAGTAGAGAGGATTGGGGTGATTGTACTGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAGGCGAAAAGGGGCCGTGGTGGCTGGGAGTCGAGGTACTTCTTGAAGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCTTCGCACTTGGGAAGTCGGGGCTACACTCCCATTTATACCCCCTTTTTCATGAGAAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACCTCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCATCGCTGCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATGCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGTGGCTCCCACGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAGATTGAACAGTATTGTGTATCATCACCACATGACAACAAGTCGTGGGAGATGTTTGAAGAGATGATTACCACCGCGGAGGAATTCTACCAGTCCTGGGCATTCCTTACCACATCGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAGATGATGGACAAGAGAAGAATAATCTCCATTTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCTTTGTGAAGCCTGCGCCCATTGACCAGGAGCCATCCAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCGGCAGCAAGAGACGTCACCCTAGAAAGCAGGCTGCAGAACATGGAGGTCACCGATGCCTGAACACTTCCTGCGTCCCTGTTTGCTTTCATTTCTGTCCGCTGAGATCTCAGAGCCTGCCCAACAGCAGGAAGCCAAGCACCCATTCATCGCCCTGCCCCATCTGACTGTGGAGCTGAGAGGGGAGCAGTGCCGTGTACCACACAGATGTTCCTGTCTCCTTGCATGGGCATAGGAAACCCATCGCTGATGACTGATGAACCATGTAATAAAGCATACTCTG + &(&$+)(,.',(--*--$&+&)(&+)(-,&,)"%),'(--(-+)$++),.,%&+('%%&#$(#%'*,,,.,,'--,--&,,'+(,-*),,($&),,.+,(+),,,.,,)(--'-,+)+,*)'*%$+''+(+----)+---,(((--**&'++-,----+%+-*))),&,--+-(*,.,&+)&++)-,--*$,'+.)+---,----)-&&++--+,)')(+(,.-('%+(-),--(+%(.--,(*(*+,)+((#$$+---('+,+(+,()'(),&++),(,-,--,(((+%&,,,((%%)%&'',((-,-(-'()))..))**)(+)-,,+$*,+++)'+*-)&*+,((()+(,,(++(---,.)+%+**('#''++),,-,&)()')----$$%*)%))+,,(,$,*+,+(**$*-,(----,-$&*(((,%+'-'%"(*+*-)(,-)'()++%&(('),))+-,((*,&('+(+()'(,+()-,,),)-,$+$(,,()(+.,-,+,(+*-)))-,)+,**,,(%*)),%*-+%,,&**',,&+,'----+($,(%'*)$*.-,(-+'$))))',,(,(')*,(-*),,()$$+&(($'*),-*,#*+'&(.,'-%&$%%'*')',+,*),+-,),-*.-*,'-+$('(&&,)#&$*),,,),,%++,-(%,--+)-,,,-,-+'%,*'++*-,.,(&('('(,*-*&,*&(,(,*,)&(()%(*%*)*))('#$('+#%(,',--.*(,%''#+,+-(-,)-,-(-+*-',*(-,,+(--(%&*)'%,)+,(&%%$$()-+&&+(,$&(*,')*,)(+((+)'(($&(&(+)+$'&,-(,("#,)(,+-.)-,&,,'*+))+(+*,.(-+,+&&'%(*%&++,,#(&,'+)++#')-(,(*+(*(*---,)-%&'(,,(&&#&$+*&"(),,&-(---,(++''%('&(-(,($(%++,)'&()*,'(',-'%)%))%*&+),(+'#&('$%)$$,$+*)#())())(+)-'&*&'(()&(',('&'$%&(#+*),()&)*-*(,(()))&,*,.+,+-((),+)'&).)'--,'(-(+(-((-(*+))--,),)*)&&(+)'((-&+(&&#+,-)--,((),',('+'-,'+('"&(,,*$*.,%,,-(%))--,-(,-((+-,.,%&)).(-,),+*$)%'&&'&**,,%*+,(,10--/02+#&'-.2-,,.(+,.,$')+)*0-$*(0/+,,+&+,+&+(//&)'#*)&0/-*,/.*,10*#**-1+/2)*(,(/#))+,/'*/.-0/1--+#*-+.-0-&+1.2)0-1101)-*$(+/',+02)0.,0/(+01+,&-/'-,'&*++,*.0*.,-,+&*,,/01+/1.--+'(.-10.,#$&,*&'00+.(+)/1.-0/,,210,-**+'*0-22/(**-+0,+)021.1+)21-0,-,,1+('0010+/2/12102+/,00&0+10111)&#--*.1(+,1/11,+1&,)/20/4.4.53,..30641)544+065.3412/-000556464..43*(00101-/&+53.2,'./4/',*'-.)/0+2,21.(+'(*(.1)-()0.355+3/..,4.454'01.0+1./1++/'*%)+-02//3*'.-)+.0-0.'0.)-)15405006/)/4212220)20/-+11/,**351.(/1(//2/-60/(&'),+,'().0..0614+(4..022+265/010.//43.,34+-/*0/2)*$*%-%)/1+-4-4020+.1,*32155504)-/30/41(-4554/12'*-*(552243)-01*331021*#-+5-0+*211-/5/*-)%*02-& @rCer/1249/1294_58_CCS TAGAGAAGAGATGCTGTCTTGGTCTTGTTGGAGGAACTTGCTTTAGTTAGATGTCTCATTATTGAGTTACCTATTATTGTTGAAATAACTATTTGTATGGATTTAGATGGTAATGGCATTTTGATATTGGCTTCCTTTCTTACAGGCTTGATTTGCCTGGTGACGAATTACTAGTGACTAGTTTACTAACTAGGTCATTCAAGGAAGTCAAGTTAACTTAAACCTGTCACCTAATGTACTTGATAGTGTTGAAATGTCCACCTTCTTAAATTTTTAAGATGAATTAGTTCTAAAGAAGATAACAGGCCAGTCCTGAAGGTACTCCCAGTCCCAGTTTGCTGCAGATCTCGTATTTTGGATGTTGTATAAGAGTCCTATTTGCCCAGTTAATTCAACTTTTTTTTTTTTTTCTTTTTTTTTTTTTTTGAGAAGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCTCCGGGTTCACGCCATTCTCTGCCTCAGCCTCCCGAGTACTTGGGACTACAGGCGCCCACAACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGTTTCACCGTGGTCTCGATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATTCAACTTTTTTCTACCTATTTATGGACTGTCTGCTCTGTTAGAACTCTGTCCAAAAGTGCATGGAATATAATTTGTAAAGCTTCCACAGCTGACAATATATGTGCATGTGTTTAAACCAATCCAGAAAGCTTACAATAGAACTGCATAATAGTATTTATTAAAGAATCACAATTGTAAACATGAGAATAACTTAAGGATTCTAGTTTCGTTTTTGTAATTGCAAATTATATTTTGCTGCTGATAATAATTTTTAAATGTCATCTTGAAATAGAAATATGTATTTAAGCACTCATGCAAAGGTAAATGAACACTTTTTAAACGTGTGTGTTGCTTATTTTTCCATAAGAATTGTAAACATTGAACTGAACAATTACCTGTAATGGATTTGATTAATGACTTATGAGCAAGCTGGTTTGGCCAGACAGTATACCCAAACTTTTATGTATTACAGAAGGCTATTACACTTGTGAAATTCTCTTGTCTAATCTAAATTACATTCCATGGCGATAACATGGCATATGTATGTATAAAGTAAGTGACCC + 0'0.27,224-+02(1/-5+814,:145+33/;894&612589+4171+5/)1/0+039329+1".4+)8-4/8,9:1882.0.)//'&,026194.6;51::1-1+%0.4.*'0/41668+/*.)0'2329<79:<22:8<71?95:+;9?=17;22*(5/*$:4(9-.)5,38+969=69:'5138&?;4A>?;=;8==,B6CA>?;A5>?7:;AC8:=.>3;38:;=89:$-02:4>5;,909=@C=67;-975B.:?.=6A?6;:(78:8)=3><=A6#1616=4?<==484/>>A><9<;1?.81=<-9:6'<+)-4;7>235==A+60=:5<9@;9:9'5*51?<989?/=:<>:72<67/=)6:<7825=9;&667'4<@8<<=A=9;9$#1GIEHI'0GIHGHIFEGHHHEF$6)4<&B/5;8'';<>8?-46/778&/=047=-(..475,77'365555*:6726*-1&*535,5,)9,6'1;%251=57;556-8=+62(>8;205,23)6=A'>@7DCF>.KJ=F=>?IB@71=AC+3;?-C>EJ@GJ2H@KDI@JEDHJ(C7@>@:6$8FGFBEIGB>?((6'32:9@AB9855@I:B=DB85B;@??>D?F>&F4?DB5<8&??E8FEI9B8@)88745AK>@.=69%7:>=,9@$1D65E%CF(6ECDD(B3>3DF%D0?@=DIFDEEA6?6AFC*28D6@@D>><.)C?+B@825=04A9191*:@>=B$;<.DF;4A5<7B?:9'<:A9?G@C??9818$(,DDA=A6>2-:BE=>9:=9>=C8?4-.4/7=3().3(29%9<89';80603-43*34+:*704;(,;?9A0=50=<(1$1675*61%1857<>:*#?$(-,A1<8-/5=>9:/6/:6=<*45@;5663#/$)+'4&98:)*<470-% @rCer/1250/2161_72_CCS TGCTGACTGTGTCATATACTTCTTGCTCGTACTACTCGCGTTTTCCCATATCCATGTGGGTCCTGTCATTACTGTTGTGGTGGTTTGTTTTACTCCTCTTGATTCGCGGTTGCGGGAAGGTTGGTGAGTAGCCCGAGGTCCTTATGACGATCGGTGGACCTAACTAGTGATTATGTTCGGAGATGTGTCAGATACTTTCGCTTAAAAAGCTTTAAGGGCCTGTTTGCGCTATCGGCTTACTTGCGTGTGTTTGAGAGTATGTTTAATGTTGGTGATTCATCTTTCACAAAGCCTCAGCGATTCTCACGTACCTCCTATTGAATCAGTGGTTGCTATGATGTCGTGTCGCCAATTTTGGGATGCTGCTGAATTATGTCTCTTCATGTTATTTCCCAGCAGTGCCTGGTGCTCCTGTAGGTTCGCTTCCTTTAAAGGAATCCCAAATGTCTAGCCACTCTTGATTTAGTAGATGTGTCTGTTGCTTATGCTTCTGCTAAGTTGCGTTGGTGGTCCTTTCACATTATACCAGGAGGTGTTTGAATGTAGTAACTCCATGACTGTGCTGGTATCTGTATTGTGTTCAGTGAAGGGCTGGTAGAATGTGAAAGGTTAGTGTGAGGAGGGTGTTTGGGGAGAGGGAGTGGTTGGGAGAGGGAGAGGGAATCATTGACATTTTTAATGTTTGTATTAATGTAATTGGTGTAAACGAATATTGATCATGCTTGTGTTTATGATAGTTGTTTCCTAAGCCTGAATATGAATGACTGTGGATAGTGCATGTGTAGGGAGGAATACTTCGTTCCCTCTGTGTGTTCGGTATCTCGCTTTTCTCTTTTTTTTTTTTTGTGGCTAAGCTAGGCATAACGTGCTTTTGGTTGTTGTCCTTAAATGTGGCAAATGTGTATTTGTGACGTGGTATTGTAGACCTTGTGTGATTGTAATAAAAGGTTGGTGTTTTTTAGATAAATGAGGTTGTTGGATTTTTGAGTATTCGTTGCCGCTCTGGGGATTTCTCTTTGGTGGGTGGCTGCGTGCCAAGAATTCCTTAGTAATACTTGTAAAGTAGCAAACTAAGCGCGGCGTGGGACGTGTCCTGTCATTGATCGATCTCTCTGTCTTCGCACTTACCATCACCAACTGTTTGCTTTTCTCTGTAATCGAGATTAAAAGTTTGAGTCTCCAGTTTTTGATTTTGCTTAGTTTGTTGGTTGGTTTTAGACTCTTGATGGTCTTTGTGAGGTGTAGAGACCCACCTCAATATCGTGAATTGCTGTGTCAGCGCAAAGAAGTGGTAGCGGGTATTCAATGTCGGGTCTTCCTCTGCCCCCATGGGAGGATGTCGGTGATGGGTTGTGTGGTGACTATCAGTATTTATTGCGGGTAGTGAGATGTGAGAGTAAGTCTGTTGTTGTGTTGGCCAATCAGCGTGTGTGATGATGATCGATCGAAATGATGTGGGGACTGAGGACGTTGCATCTGTGCTCCGCCGAGCTGTGTGAGAGGTCGCATAGTAACTAAGGCTTGCATTGATTGTTTAGTGTGGCTCTGTGGGGAATATTACCGTTTCTGGCAGCTGTTTTTTTTGTGTTCTTAACCCGGTTCAGTGGTAAAGAGCTCCTCCGTGGGCAGAGGTCTCCGTAGATTAGAATAGTCCTTCTAGGTGCTGGATTGCGGCAGCTTCAAAAATTTCTTTCCTACTACCGTTTTGATAAAGTTTGAGGGGATTAGCTTGTTGGTGGACTCTACCTACTGGGTGGTGTTGTATTTTTTGTTCGTCGTTTTGTGTTGTTTTGTTCTGTTTTGACTTGTGTATTGTGAATACGCGCGGTGAATTCTCAGTAGTTTGCGTACGTGTATAAAGACGGCCTCTAGTGAGTGTGTATGGGAAAGGGCAGATTGTGGTTTTAGACGCCTGTCCGTGATGGCGAGAGAAAAGAAACTATAGATATTAAACTACTTTCTTTGCGCCGCCTGTTGCAGATTTTTTCTTGTGGGAGGGGGGCTAGGTTTTCCAGCGTTGCAGGGGGTGTGACGTGCGCATCTCTCGTGCATGTGAGAGGAAAATGACGGTAGAAGCGTCAATTAGACT + 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@rCer/1252/1814_51_CCS ATGGGGGCCAAGCGGCCGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCAAGCGGGGGTCCCGGAGCCAGAGGGCCAATTCCGTCCCCCCAGCGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCGCTGCCCGCCGGGTCCCACCACTCGAGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGTGGGAGGAAGAGGAGGAGGAAGGGAGGAGGAGGATGACCTGAGTGAGCTGCCACCACTGGAGGACATGGGACAACCCCCGTGGAGGAGGCTGAGCAGCTGGGGCCCTGGCCCGAGAGTTCCTCGCTGCCATGGAACCCGAGCCCGCCCAGCCCGGCCCGAAGAGTGGCTGGACATTCTGGGAACGGGCTGTTGAGGAAAGACGCTGGTCCCAGGGCCACCAGGTTCGAGCCGCCCAGTCAAGGCCAGGTGGCACCGACATCTACAGACGTCGCTGGAGAACGGCACACGGGTGCAGGAGAGCCGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCTTGGATCTCAGTGTCCACTCATGGACGTTGGGGAACGGCCATGGTCACTGCTGACTCCAGTACTGCTACGGCCCCAAGCAGCAGGAGCCCATACATCCCCCGCATGCGGCCCTGTGCCTGGAGGTGACCCTGAAGACGGCCGTGGACGGCCTGACCTGGAGATGCTCACGGGGCAGGAGCGCGTGGCCCTGGCCAACCGAAAGCGGGAGTGCGGCAACGCCCACTACAGCGGGCGGACTTCGTCCTGGCCGCCAACTCCTACGACCTCGCCATCAAGGCCATCACCTCCAGCGCCAAAGTGGACATGACGTTTCGAGGAGGAGGCACAGCTCCTGCAGTTGAAGGTAAGTGTCTGAACAACCTGGCGGCCTCGCAGCTGAAGCTCGACCACTACCGCGCGCCCTGCGCTCCTGCAGCCTTGTGCTGGAGCACCAGCCAGATAACATCAAGGCTCTCTTCCGCAAGGGCAAGGTGTGGCCAGCAGGGGGAGTACAGTGAGGCATCCCATCCTGAGGGCGGCCCTGAAGCTGGAACCTTCCAACAAGACGATCCACGCAGAACTCTCGAAGCTGGTGAAGAAGCATGCAGCACAGCGGAGCACAGAGACCGCCTTGTACCGGAAATGCTGGGCAACCCCAGCCGGCTGCCTGCCAAGTGCCCTGGCAAGGGTGCCTGGTCCATCCCATGGAAGTGGCTGTTTGGGCAACTGCTGTTGCCTTGGGGGGTTGTGGCACCACCCCCCCTCCCCACACCCGCTCTGCGGGCTAGCCTGCCACTCTCTGTGGTCATCGCTGCCAGGAACTGACCGCCCAGGTGGCCGCCACTCCTCTGCACACCATGGACCCTGCCCTGCGCTTCCAACTCCCCAGGCTCCTGTCCACTGCCCTCCCTGGTCTAGCCCCTCCTCCGGGTTAGGGGAGCAGGGATTGGGGGTCGTGCAGCCCAGCCAGCAGGAGGGACTAAGGCCCTCTAGGGAAAGCCCAGAGGGAGGGGCCCTCATTCCTTCAGACCAGTTTTCCCCACCCTCCTAGTCTGCTGGGCTAGGTCTCCGCCAGGGCCGGCCTCAGTTTCTCCTCAACAGGCCTGGGGGCAGCCCTTCCCCTGCCTAGTCCCCGCCTGAGTGCCAGCCCCCCTGCCCGCCTGCCGCCCCCTGTCCAGGCTCCTCCCCGCCACAGTGAAATAAAGCCTCCATCCT 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@rCer/1253/25_2139_CCS ATGGGGATGCTCCTTGCCGCGCGGGTGGAGAGCGCCGGGGCAGGGAGGCGAGCACCAGGCGCTGGTCCCTCCGGGCAGGGGAGGTAGGCCTGGGCCTGACGCCGGCCACGCAGCAGCGGGAGAGTGAGCACCCGGGCGGCGGCGTCCTGGAGACCCGCGAGAGATGGAAGCGGCGGCGACGCCGGCGACGGCCGGGGCGGCGGGGTGCGAGGAGCTAGAGATGGATGTAATGAGGCCTTTGATAAATGAGCAGAATTTTGATGGGACATCAGATGAAGAACATGAGCAAGAGCTTCTGCCTGTTCAGAAGCATTACCAACTTGATGATCAAGAGGGCATTTCATTTGTACAAACTCTTATACACCTTCTTAAAGGAAATATTGGAACTGGCCTTTTAGGACTTCCATTGGCAATAAAAAATGCAGGCATAGTGCTTGGACCAATCAGCCTTGTGTTTATAGGAATTATTTCTCTTCACTGTATGCACATATTGGTACGTTGCAGTCACTTTCTGTGTCTGAGGTTTAAAAAGTCAACATTAGGTTACGGGACACCGTGAGCTTTGCTATGGAAGTGAGTCCTTGGAGTTGTCTTCAGAAGCAAGCAGCGTGGGGACGGAGTGTGGTTGACTTTTTTCTGGTGATAACACAGCTGGATTCTGTAGTGTTTATATTGTCTTCTTAGCTGAAAATGTGAAACAAGTTCATGAAGGATTCCTGGAGAGTAAAGTGTTTATTTCGAATAGTACCAATTCATCAAATCCATGTGAGAGAAGAAGTGTTGACCTAAGGATATATATGCTTTGCTTTCTTCCATTTATAATTCTTTTGGTCTTCATTCGTGAACTAAAGAATCTATTTGTACTTTCATTCCTTGCCAACGTTTCCATGACTGTCAGTCTTGTGATAATTTACCAGTATGTTGTCAGGAACATGCCGGATCCCCACAACCTTCCAATAGTAGCTGGCTGGAAGAAATACCTACTCTTTTTTGGTACTGCTGTATTTGCTTTTGAAGGCATAGGAGTGGTCCTTCCACTGGAAAACCAAATGAAAGAATCAAAGCGTTTCCCTCAAGCGTTGAATATTGGCATGGGGATTGTTACGACTGTGTATGTAACATTAGCTACTTTAGGATATATGTGTTTCCGTGATGAAATCAAAGGCAGCATAACTTTAAATCTTCCCCAAGACGTATGGTTATATCAATCAGTGAAAATTCTGTATTCCTTTGGCATTTTTGTGACATATTCAATTCAGTTCTATGTTCCAGCAGAGATCATTATCCCTGGGATCACATCCAAATTTCATACTAAATGGAAGCAAATCTGTGAATTTGGGATAAGATCCTTCTTGGTTAGTATTACTTGTGCCGGAGCAATTCTTATTCCTCGTTTAGACATTGTGATTCCTTCGTTGGAGCTGTGAGCAGCAGCACATTGGCTCTAATCCTGCCACCTTTGGTTGAAATTCTTACATTTTCTAAGGAACATTATAATATATGGATGGTCCTGAAAAATATTTCTATAGCATTCATTGGAGTTGTTGGCTTCTTATTAGGTACATATATAACTGTTGAAGAAATTATTTATCCTACTCCCAAAGTTGTAGCTGGCACTCCACAAAGTCCTTTTCTAAATTTGAATTCAACATGCTTAACATCTGGTTTGAAATAGTAAAAGCAGAATCATGAGTCTTCTATTTTTGTCTCATTTCTGAAAATTATCAAGATAACTAGTAAAATACATTGCCATATACTTAAAAATGGTAACAAACTGTTTTCTTTTGGCATAGTATTATTATTTTGGAAGTAATCATAGCTCTTTACCAGTAGTGGTAAACCTATGACAAATCCTTGCTTTTAAGTATTAGCAATAGTTTCAACAAATTAAGTTCTGAAAATTGAAAAAATTAAAATGTAAAAAAATTAAAGAATAAGAATACTTCTATTATTCTTTTATCTCAGTAAGAAATACCTTAACCAAGATATCTCTTTTGCCTCTCACTTGAGAAGGGAATAGGATTTCAACAATAAGAGAATAAAATAGAATATATGTAACAAAAAGCTCTCTCCAGATCATCCTCGTGAATGCCAAAGTAAACTTTATGTATAAT 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@rCer/1254/2168_55_CCS TGGGCCGCAGCGAGGGAGATGCTGGCGAGCGGCAGCGCGATCCTCTCCAGGCCTTGCGGCGCGCAATCAGGAGCTGAAGCAACAGGTTGATAATTTGCTTTCTGAGAGCCAACTGAAAGAAGAAGCCTAGAACCCAATAAAAGACAAGATATTTATCAAAGATGTATCCAGTTAAAGCAGCAATAGATGAAAATAAAAATGCTCTTCAAAAATTAAGCAAAGCTGATGAATCTGCACCTGTTGCAAACTATAACCAGAGAAAAGAAGAGGAGCATACTCTTTTGGACAAGCTTACCCAACAACTGCAGGGCCTTGCTGTGACAATAAGTAGAAAAAATATAACTGAAGTTGGGGCACCTACTGAACAGAGGAAGAAGTGAAAGTGAAGAAAGTGAAGACAGTGTGAGGAGGAAGAAGTACAGAGGAGGAAGAGGAAGAGAAAGAGGAAAATGAATATCACAAACCATCAACCGGTGAAGAATACATCGCTGTTGGAGATTTCACTGCTCAGCAAGCTGGAGATCTACATTTAGAAAGGGAAATTCTCCTTGTAATGAAAAAAAACCTGATGGTTGGTGGATAGCTAAGGATGCCAAAGGAAATGAAGGTCTCGTTCCTAGAACCTACTAGAGCCTTATAGTGAAGAAGAAGAAGAAGGCCAAGAATCAATTGAAGAGGGCAGTGAAGAAGATGTAGAGGTGGTGGATGAAACAGCAGATGGAGCAGAAGTTAAGCAAAGAACTGATTCCACTGGAGTGCTGTTCAAAAAGCAATCTCAGAGCAGATAAACACTGTTGATGTGTTAACCACGATGGGAGCTATTCCTGCAGGGTTCAGGCTTCCACACTCTCGCAGCTTCTGGAGAAGGGAATCAATTTCGAGCAAGTTACTTCCTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCAAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAATCTAAAAAGCCCAAACATGGACTTTTCTCCCCAGGTTAGTCGCATCTTGCCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCCAATTCTGCATCTCCAGATGTTGGATATTATTTGAACTTGGATTTCTTATATTCGCAATTCAACTGGAGAAGAGGAGAGTTAAGTTGTGGCTGGGTGTTTCTTAAACTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTGTTGACGTGGACCTTCAGTATCAGAAGAGCACATGGCAGTGTTTTCTACAGATGATGCAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCGAGAAATGTACTAAGTCTACTGCCGGAACATTAATTGGAAGTATGTGTTCTGTTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCATGCTCTTGGAGCAGCCTGACGTGATGGATGCCCTCAGGAGTTCATGGGCTGAAAAAGAAAGTATGTTAAAAGATCAGAGAAGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCACTTCTCCACTCCACACGCTGCCCCCATTCAGGTGGGCAGAAGAGGATCTGAGACTGCACGATGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGTGCCCTCCAAGCTCTGCTGTCGCCAGACGGAATTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGATGGTGACAGCCTCTAGCCTCAGCTTCCACGGAATCAGATGGATCCTCCAGATTACGTGAATAAAATGATGGAACCAAAATTACTGTCACT 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ATGGGGGACTCAGCGTGCGCGGGGCCCGCGGGCCGGGCCGGGGTGACCTGGGCTGCAGCCATGGAAGAACAGAGGAGGCCCTGAGGAAGATCATCACAACACTGGCTATGAAGAATGAAGAAATTCAGAGCTTTATCTATTCCCTGAAACAGATGCTGCTGAATGTGGAGGCGAACTCGACGAAGGTGCAGGAGGACCTCAAAGCAGAGTTCCAGTCCCTCTTCTCCGTCCTGGAGGAGCTGAAAGAAGGCATGCTTATGAAGATAAAACAGGACCGTGCCAGCCGCACCTACGAGCTGCAGAACCAGCTGGCTGCCTGCACGCGGGCCCTGGAGAGCTCCGAGGAGCTTCTGGAGACAGCCAACCAGACTCTCCAGGCCATGGACCGCGAGGATTTTCCTCAGGCTGCCAAGCAAATCAAAGATGGAGTGACCATGGCCCCTGCCTTCCGGCTATCACTGAAAGCGAAGGTCAGTGACAACATGAGTCACCTCATGGTGGACTTCGCACAAGAGCGGCAGATGCTACAGGCACTCAAGTTTCTGCCTGTGCCCAGCGCGCCGGTGATCGACCTGGCCGAGTCCCTGGTGGCAGATAACTGTGTGACCCTGGTGTGGCGCATGCCGGATGAGGACAGCAAGATTGACCACTACGTGCTGGAGTACCGGCGGACCAACTTCGAGGGCCCGCCCGTCTCAAGGAGGACCAGCCCTGGATGGTCATCGAGGGAATCCGGCAGACAGAGTACACTCTGACAGGTCTCAAGTTTGACATGAAATACATGAATTTCCGCGTGAAGGCCTGTAACAAGGCAGTTGCAGGAGAGTTCTCTGAGCCGGTGACTCTGGAGACACCAGCGTTCATGTTCCGCCTGGATGCGTCCACATCCCACCAGAACCTGCGGGTGGATGATCTCTCCGTGGAGTGGGACGCTATGGGCGGGAAGGTGCAGGATATCAAGGCTCGCGAGAAAGATGGCAAGGGGCGGACGGCGTCTCCCATCAATTCCCCGGCCAGAGGTACTCCATCTCCCAAGAGGATGCCCTCAGGTCGTGGGGGTCGGGACCGGCTTCACCGCTGAGTCCTACACAGTGCTGGGGGACACGCTGATCGACGGCGGGGAGCATTACTGGGAGGTGCGCTACGAGCCGGACAGCAAGGCGTTCGGTGTGGGCGTGGCCTACCGCAGCCTGGGCCGCTTTCGAACAACTGGGCAAGACGGCCGCCTCCTGGTGCCTGCATGTCAACAATTGGCTGCAGGTCAGCTTCACGGCCAAGCATGCCAACAAGGTCAAGGTGCTGGACGCCCCCGTGCCCGACTGCCTGGGTGTGCACTGTGACTTCCACCAAGGCCTCCTGTCCTTTTACAACGCCCGCACCAAACAAGTGCTGCACACTTTCAAGACCAGGTTCACACAGCCCCTGCTGCCTGCTTTCACGGTATGGTGTGGCAGCTTCCAGGTGACGACAGGCCTGCAGGTCCCAGTTCTGTGCGCTGCCTGCAAAAGCGAGGCAGTGCTACCAGCAGCTCCAACACCAGCCTCACCTAGGCCCCAGGCACCCACCCAGCTGGGGTGTTCTTGGGGGAGCCGCTGCCAGGCCCAGGCTGCTGGAGCCAGGCATCCTACTCTGTCATTTGCTGCTTGGAGCCTTAACTCTGGATGGGGGGTCACCAAGAGGGAGCGGGCACCCTGGCGGCCCTCCTCCCCACCTCACCTCTTAATAAAGGTCAAACACTGGCCAGG 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@rCer/1261/2215_57_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCGGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT 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@rCer/1263/25_1945_CCS ATGGGGATACTGAGCTGCATTGCCTTTACTGTGGAGTTTTTTGTTGCCGGTTCTGCTCCCTAATCTTTCCTTTCTGACGTGCCTGAGCATGTCCACATTAGAATCTGTGACATACCTACCTGAAAAAGGTTTATATTGTCAGAGACTGCCAAGCAGCCGGACACACGGGGGCACAGAATCACTGAAGGGGAAAAATACAGAAAATATGGGTTTCTACGGCACATTAAAATGATTTTTTACAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTTGTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGATGGCTGAAAATGTTTCAGAGCTGGAGCGGACCAGAGAAATTGCTTGCTTTAGATGAACTCATTGATAGTTGTGAACCAACACAAGTAAAACATATGATGCAAGTGATAGAACCCCAGTTTCAACGAGACTTCATTTCATTGCTCCCTAAAGAGTTGGCACTCTATGTGCTTTCATTCCTGGAACCCAAAGACCTGCTACAAGCGGCTCAGACATGTCGCTATTGGAGAATTTTGGCTGAAGACAACCTTCTCTGGAGAGAGAAATGCAAAGAAGAGGGGATTGATGAACCGTTGCACATCAAGAGAAGAAAAGTAATAAAACCAGGTTTCATACACAGTCCATGGAAAAGTGCATACATCAGACAGCACAGAATGATACTAACTGGAGGCGAGAGAGAACTCAAATCTCCTAAGGTGCTGAAAGGACATGATGATCATGTGATCACATGCTTACAGTTTTGTGGTAACCGAATAGTTAGTGGTTCTGATGACAACACTCTAAAAGTTTGGTCAGCAGTCACGGGCAAATGTCTGAGAACATTAGTGGGACATACAGGTGGAGTATGGTCATCACAAATGAGAGACAACATCATCATTAGTGGATCTACCGATCGGACTCTCAAAGTGTGGAATGCAGAGACTGGAGAAATGTATACACACCTTATATGGGCATACTTCCACAGTGCGTTGTATGCATCTTCATGAAAAAAGAGTTGTTAGCGGTTCCGAGATGCCATCTTAGGGTTTGGGATATTGAGACAGGCCAGTGTTTACATGTTTTGATGGGTCATGTTGCAGCAGTCCGCTGTGTTCATATGATGGCAGGAGGTTGTTAGGGAGCATATGATTTTATGGTAAAGGTGTGGGATCCAGAGACTGAAACCTGTCTACACACGTTGCAGGGGCATACTAATAGAGTCTATTCATTACAGTTTGATGGTATCCATGTGGTGAGTGGATCTCTGATACATCAATTCGCGTTTGGGATGTGGCAGACAGGGAATTGCATTCCACACGTTAACAGGGCACCAGTCGTTAACAAGTGGAATGGAAACTCAAAGACAATATTCTTGTCTCTGGGAATGCAGATTCTACAGTTAAAATCTGGGATATCAAAACAGGACAGTGTTTACAAACATTGCAAGGTCCCAACAAGCATCAGAGTGCTGTGACCTGTTTTACAGTTCAACAAGAACTTTGTAATTACCACTCAGATGATGGAACTGTAAAAACTATGGGCATTGAAACGGTTGAATTTATTCGAACTGATCACTTTGGAGAGTGGGGGGAGTGGGGGAGTCGTGTGGCGGATCAGAGCCTCAACACAAAGCTGGTGTGTGCAGTTGGGAGTCGGAATGGGACTGAAGAAACCAAGCTGCTGGTGACTTTTTAGTGAGGCAAGAAGATAGCAGGAAAATGCTGATTTTTGTCTATTGTGTAGAGCACGATATACTCCCTGCCCTTCCCCCT 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@rCer/1264/25_2465_CCS ATGGGACACAGGCGGCGGCTGCGGGCGCAGAGCGGAGATGCAGCGGCTCGGGGCCACCCTGCTGTGCCTGCTGCTGGCGGCGGCAGTCCCCACGGCCCCGCGCCCGCTCCGACGGCGACCTCGGCTCCCGTCGAGCCCGGCCCGGCTTTCAGCTACCCACAGGAGGAGGCCACGCTCAACGAGATGTTCCGCGAGGTTGAGGAACTGATGGAGGACACGCAGCACAAATTGCGCAGCGCGGTGGAGGAGATGGAGGCAGAAGAAGCGGCTGCCAAAGCGTCATCAGAAGTGAACCTGGCAAACTTACCTCCCAGCTATCACAATGAGACCAACACAGACACCAAAGTTGGAAATAATACCATCCATGTGCACCGAGAAATTCACAAGATAACCAACAACCAGACTGGCCAAACGGTCTTTTCAGAGACAGTTATCACGTCTGTGGGAGATGAAGAAGGCAGAAGGAGCCACGAGTGCATCATCGATGAGGACTGCGGGCCCAGCAAGTACTGCCAGTTTGCCAGCTTCCAGTACACCTGCCAGCCGTGCCGGGACCAGCGGACACTCTGCACCCGGGACAGTGAGTGCTGTGGAGACCAGCTGTGTGTCTGGGGTCACTGCACCAAAATGGCCACCAGGGGCAGCAATGGGACCATCTGCGACAACCAGAGGGACTGCCGGCCTGGACTGTGTTGTGCCTTCCAGAGAGGCCTGCTGTTCCCTGTGTGCACACCCCTGCCTGTGGAGGGCGAGCTTTGCCATGACCCCGCCAGCCGGCTTCTGGACCTCATCACTTGGGAGCTGGAGCCTGATGGAGCCTTGGACCGATGCCCTTGTGCCAGTGGCCTCCTCTGCCAGCCCCACAGCCACAGCCTGGTGTACGTGTGCAAGCCGACCTTCGTGGGGAGCCGTGACCAAGATGGGGAGATCCTGCTGCCCAGAGAGGCTCCCGATGAGTATGAAGTTGGCAGCTTCATGGAGGAGGTGCGCCAGGAGCTGGAGGACCTGGAGAGGAGCCTGACTGAAGAGATGGCGCTGGGGGAGCCTGCGGCTGCCGCTGCCGCACTGCTGAGAGGGGAAGAGATTTAGATCTGGACCAGGCTGTGGGTAGATGTGCAATAGAAATAGCTAATTTATTTCCCCAGGTGTGTGCTTTAGGCGTGGGCTGACCAGGCTTCTTCCTACATCTTCTTCCCAGTAAATTTCCCCTCTGGCTTGACAGCATGAGGTGCTGTGCATTTATTCAGCTCCCCCAGGCTGTTCTCCGGACGTCACAGTCTGGTGCTTGGGAAAGTCAGGCAGGGTTAAAGACAGGACCAGGCTGCCACCCCTGTCCAGATTATTGACTGCTTTGCCTCTACCGGTTGGCAGACAGCAGTTTGTTCTACATGGCTTGATAATTGTTTGAGGGGAGGAGATGGAAAGAATGTAGAGTCTCCCTATGATGGGTTTTGGGGAAATGTGGAGAAGAGTGCCCTGCTTTGCAAACATCAACCTGGCAAAAATGCAACAAAGCAATTTTCCACGCAGTTCTTTCCATGGGCATAGGTAAGCTGTGCCTTCAGCTGTTGCAGATGAAATGTTCTGTTCACCCTGCGTTACATGTGTTTCTTCATCCAGCAGTGTTGCTCAGCTCCTGCCTCTGTGCCGGGGCAGCGTTTTCATATCCACGATCAATTCCCTCTCTCAGCACAGCCTGGGGAGGGGGTCATTGTTCTCATCCATCGGGGATCTCAGAGGCTCAGAGACTGCAAGCTGCTTGCCCAAGTCACACAGCTAGTGAAGACCAGGGCAGTTTCACCTGGTTGTGACTCCAAGCTCAGTATTCTCTCCACTACCCCATACCAGCTTTGGTGCCACCAAAAGCACTCCCCAAAAGGAAGGAGAATGGGACTTTTCTTTTGAGGCATGCACATCTGGAATTAAGGTCAAACGAATTCTCACATTCCTCTGAAATTAAACTTCTGTTAGGAACAGCAGTGTTCTCACAGTGTGGGGCAGCCATCCTTCTGATGGAAACAATGGTTTTGACACTGTCCCTCTTTGGTAGTTGCATTAGTAACTTTGAAAGGTACATGACTGAGCATAGCATATAGGTTAACTTGCAGAAACAGTACGTAGGTAATTGTAGGGTGAGGATTATAAATGAAATGTGCAAAATCACTTAGCAGCAACTGAAGACCATTATCAACCACGTGGAGAAAATCAAACTGAGCAGGGCTGTGTGAAATATCGTTGTAATATGCAGACTGCGAACACTGAACTCTACGCCACTCCACAAATGATGTTTTCAGGTGTCATGGACTGTTGCCACCATGTATTCATCCAGAGTTATTAAAGTTTAAAGTTGCACATGATTGTATAAGCATGCTTTCTTTGAGTTCTAAATTATGTATAAACACATGTTGCATTTAGAAATCAAGCATAAATCACTTCAACT 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FK-KKEIJHKIKJIKJCJDFIH:DKKKDJGIIKIKJFBAIIHIHAI?=J/KII3JBAHBCEFGDD@CGKGJGIJIGJHDIJBKGKFA;KKKGJBJ%IIIIIKFFKFH>?>,@GFHDKHDJIHCJFKAKKGJIIJDJDDGGIAFI=JIFDKCKEGJFI6EIGKFKCGKH(DGE=J?HKJCKKIICED@DJCEJJIJCCCH=HHFIEICAHDJ9FJFCKAKAKG?5;B?>IFFGJDDEEBFJGIKJH;?IJKJJJHK?FIFIGJABDEKIKC@8EIIK?K;KJJ>JFHBKKIDKJHJIHIGFIFAEBGIEKBGF=KDAJHBHEKG9GEEKI>&IFKCHCJIKGEEGH:B2HCEHGKEGHIJCCIB?+JH@KEJJKHHKIKGDHHKJFIKKJJJHHI?HHKGFKK@KJIDK>JJDEGGGI@?:KKKHDKHEI&5:@6A?I>AGCJFHKGBJGK@IDJJKDBKJFCJHFJKKJHIK>JHKIJFCJKDHHJ/JCKIIKKJJKJHDE9IF-F?HDHHJJIIBFGHBHEHKIJ:J5GKGGH8JHGJHI>JFIKKIKFEHJHH.IKKJKGK=KKGAIA0DJ-IIIG8JCI@HDJJJKKKIJDCHHJAIDGJIKIKFCJJHBCJGEFHKKHEGGJ>J@KHFD@KEIDD@GG:FCJH5HJIICHIEFBIB?@JGIG:7EGKJH?;BK=DC?>F4EHDIF@IIG3HD>EEGHJFBCEIJFJIBKKHKGGGJJJHGKBKH;G:HJGJFEFGIFIIJJ3K=DIIDICJHJ?FFKGHJJD@HEJEIJ3K>@BCGG@KJJIIJIEJHIKDFHJBIJGKAIJF@EF>EBGJKIHAJIHIDJGIDJKIIIFKFIGJHGKKJIH;JJJKGEEIKJJFJIIKCGGJJEAAJDHIIKKJIIIJAGJJDKGAAHGJJIA:?EGGKKFKKIKIEHHJCHHJHDCE>;=KIKEJG<2DCF@HJC>DG8IJHKHFKHKK@DJHHFCJGJIJACCB=>DGJJIDCFHACH>FFAHHKDKJJ?FHAFDKGHJD=FKJHIFAKJAJJKE6EEIKIDFKJHKIGGGKHCHGIFHKIGEI?HFDGCGIFJ9HGGJJKDFJHHHDKJFJHFBIE?GKE$CBCEHHEA?8GFDHKI3EE?D/<JJ?JFFEFDIJ@FJI:EJH6GIDEBFD:FEE>6FF9ICDBKIBG0EBCBFHFD-@FC:IGCEG7FEHBDCHC?HJI@5JKK?@KKJGJHKEE@IECHIJI;FHGKGKAKIKCD=HJHCIJKKFCKEIDKIKJCJIKKIGABBEGKHJKIKKJII@8EIIJ8JIIHJIFHKGJBGKKGGEKK>HIKDHGHKKKKKHFIIFIJ@GJIJC=HGAKIBBJJHCGGEFJF=IGHCCHCJJKKKJIJIKCIEFIAG?CBHIHC@=KHKJDDIGAJJICEIIGHJB>E?K@JKEHCDBBJFJHJKJGFGIKE@KBKHK;IICEKKKKGHHJIGIGIIJHFFHJJHHBDA3D@FFC7KIHG0KI@KAIFJGGGGJHJBFFJE>FFK @rCer/1266/0_493_CCS CGGGACAATGCTGCGCTGCCACTGAGGAGTTCATCAAGCGGCTGAGGTAAATGCTTGCAGCCCAGGCAAGTATGAAGGCAGTGGAGAAGATGGTGGAACAGCAGCACAGTCCCTCTACATTGCCAACATGCTACTGAGTATACTACCATACCAAGCCTTGGCCCACCATCTGCACCCACTTTGCTTGTATCATGGCCAGCCAAATACTATGCAGAGCAGATGACTTCACCTGCACCACCTGGCTTCCTTCTTCTTTCCCTCCCCATCTTCATTGCTGCACTGGACATAGATGGAGATAGGAGCCCCATGACTGAGGAAAGAATTGCTAGAGTCAGAGCAGATGGCTGGGTCTCCCCTACGTCTGACATCCCACAATTTCCCATGATGGGTAGCTTCTCTCTGGGCCTCCTTCTTGCTTGCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCTGATCATGCTTGAATACATACCATACAGCAAATAAATGG + S((**-,/,0'$&*'(&+*.*%)((+-'-1010'..010*0+&/0+/*&,%($,/01.,-+,.,$,&(+(+('-/2021-/')-**(0%(,'($&%%&'110*&%'#)')%'(+,*%&+(+,,-%*#$''#*,)+('%'##$')#$&,+-(#%"%#*%+&,,.-*#--+(('&,&*''*#'*('%**,(#''$$(##(#%)$('&($,*+&'',,,())(&%$%,,-+*(%#%%%&$&*(&+''*%&#&"$'*'($+,*+$)*''*1**1.-1/(+))*')%*-).0()(*/1*(*.*&*$('/)%'(#',,'*&'##*)$-+-&$$&')*$)-----*#$+%('((()))(',,-)*#!%),'"#$$+(-)($'#''%)&$((%+$'''),,+1'-&*%%#$%$%*#%)(,'--+-()(++/+(+133&-&(53$).000(.%)$**.240,1*'*'4../'2:5,.2,1042)00737876.336+:62'1 @rCer/1267/25_1955_CCS ATGGGGGAGAGGAAGGATGGCCGAGGTGGGAGAGACTAGAGTGAACCAGCAGGAGGAAGTCCTAGGGCGCGAAGCTACGGCGGAGATCTGTCCTGGAAAAGCCTTCTCCACCCTGGGCACTTTAAGCGGCGGTGGCGGCAAACAGCAGGAGGTTGCAGACCCGACAGCGAGCCTGCCTCATTCCAGTCTTGCTCTGCCTCCGGAGATGACAAGTGAGAAAGAAGTGTCCGGCCGGGCCATCCCTTCAGACAGAAAATCAAAGCTATTTAAAGTAAAGGATTTGTTTCAAATCAAGCTCTCACTGCAACTCTAAGTTATACAAGCCAAGAAAGGAACATTAATGGGAAATTAATGACAGTATCAAATAAAATGGAAAAGAAGATGAACCAATTACATAACGTCAACCAACCATTTTTTCAAACGGGTTTTACTGTTTGGGATTTGTCTACTCTGCTGGCATCCTTTACCAAGAATAACTGTAGAATGTGCTGGGAATGCAATGTCCTGAGATAAGGAGGAACTGCCTGAAACAGCCTGGACCTTATTCCTGTACTTCCTAGGGAATGTAACATCTCAGTTAAAGAGGACTGCCTGGGACAGCCCTGGATTGTTCCTCTCTCCTGGGAAGGAAGATCACCTCCAAAGCTTATCCATTGAGTCACACTACCCCTGTGTGGCAGGCTGCCTCTCCAGGTTCCTCAGCTGTGGTGCAACAGAAGCAAGCACAATCAAGACTCCATCTGTTCAAGGCAGCTTTCTCAAACCTTGGGGAACCTACTCACAATGGATCACAGGCTTCTTTTGTTTCTTGCTGCTTATCTTGGAAGCAAAAATCAGCTGAGTGAAGATGAGGAAGAAGGTGTTAAAGGTTTGAAGAGAAAAAATGAAAAGGATATACTAATCCAAGGGGATGCGTAAGTAGAACATAGATAATGAAAATGCTGGCCCTTAGGATTGTTGGGCGTAAATGCTCATATGATATTGGTGGTCACAAATTTTGAACTTTCTCTAAAGCCAATTTTTGCATGTGTGTGCAGGCCTGGAGTAGCTGGAGAGGTGGATTTAATAGGATTGAGGATCAAGCAACTACAACCAGAGAAGAGTGGGACAAGGGAGATAAAGGATATTGGCAGGGGAACAATTATAAACATGGACCATGATCAAAACTGAATTTGAAGGAAAATAGGGATAAGAGGGGTGGAAGGTAAAAAATAGTGGAAATGAGATAGAATTAATAGATTGTAGTCCCTGTAAAGTTGAAGAAGTATTATTATGCAGTACTCGTTATTGAAATGAGGTCACTATGCTTAAGGCACAGTGAATCCTAGAAAACAGTGGCTTTTGTTTCTCATTAGGCAATACATTCCTCTTTGCTCCAGAATGCAACATACATGCATCCTTTTCTGTACTATTATTTATTAAGAATTCATACTTAATTCTACTGACTGACACTCAATTTTAATGTACAGTAGGGAATTCCTGTACTATATAATTATGAATCCATTCCTTTGAATTTCATTTATAATACTTCATGACTGACACCTGGTTTTCCACCAAGACTCAATTTTCATAGCAAACTCATCATCATAAGCCCCAAATTAACAGGATGAGGAGGAAGAATTGGCAGGCTAAAGAAGATGATTATATCAATTAATGCAGAGAAAGCACTTGATAAAATCCAATATTCGTTTGTAATTAAAAACTCTCAACAAGTTAGGAATAGATAGGAAATTACTTCAACTTAATGAAGAGTATCTTTAAAAACCTTGAGTATTTTCATCAATTATAACAAATGTACCACTCTGGTGGTGAATGTTGATAAGGAGGGAAGCTATACATGTGTGGGGAAAGGAGATATGTGAGCAATTTCTGTACCTTCTACTCAATTTTCTGTGAGCCTAAACTTGCTGTAAAAAATAAAGTTCATTTT 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@rCer/1268/1602_52_CCS ATGGGGGACATCTCAAAGTGGGGCTGGCCCAGATTGCAGCCATGGACATCTCACGGGGCAACCACAGAGATAACAAAGCTGTGATCCGCTACCTGCCTTGGCTTTATCATCCCCCCTCTGCAATGCAGCAAGGACCTAAAAGAATTCATCGAGTGTGTCTCCCACATCCGACTGTTGTCCTGGCTTCTGCTGGGTTCCCTCACTCACAATGCAGTGTGCCCAAATGCCTCCTCTCCCTGCCTGCCCATTCCTCTGGATGCAGGCTCCCACATTGCAGACCATCTTATTGTTATCCTGATTGGATTTCCAGAGCAATCAAAGACCTCCGTGCTGCACATTGTGCTCCCTCTTCCACGCGTTCATCTTTGCTCAGCTCTGGACAGTGTATTGCGAGCAAAGTGCCGTCGCTACAAATCTCCAAAATCAGAATGAATTCAGCTTCACAGCGATACTGACAGCACTAGAAATTTTGGAGTAGGGTGACACCCAGCATCCTTCAGCTAATGGCCCATAACAAAGTGATGGTAGAAATGGTTGTGTCTCCATGTGATTAGTTTAATGGAGGCATTGCAGGAATGCAATTCGACCATTTTTGTCAAGCTGATACCTATGTGGTTGCCAATGATTCAGTCAAATATCAAGCACTTATCTGCGGGACTCCAGCTTCGCCTCCAGGCTATTCAGAACCACGTGAACCACCACAGCCTAAGGACGCTGCCGGGCTCGGGCCAGAGCAGTGCTGGCCTGGCAGCCCTCCGCAAGTGGCTGCAGTGCACTCAGTTCAAAAATGGCCCAGGTGGAGATCCAGTCCTCGGAAGCAGCCTCTCAATTTTATCCTCTATGAGTGGACTCCTCGGCGCTCAGTGTCAACACTCTGGTTTAGCAATAATGGGTTTAAAAACAAACAATTTGATCCAAGCAGGTTGGGGAACATATTGGTACTGTACATTCTCTTTCTAGTTTAGTAAAAGATGTGCAAAGGCCAGAGAGGGCCGAAAATGAAGCTTTCTTGCTACACATATTTCTGATGACTCCTTGGGCTATCTGATTAAGTGTTTCCTTACATTATTTTTTAAAAACCAAATCATTTTTCTTTTAACTAACTTCTATTTTTTTTAAGAAAAAAAAAAATATAGACTGGTGGGTACTCACAGAAAAGTTGTATAAAGTCCCCCTGTTGCTATTTTTGATGATAGAGAATAAATATGGTTTTTGAAACCTTTGTAGTGTTTTTTTCTTAAAAATCCACTCTTGGCAATGCAATAAAAAAAAAAACCGTCACCATAAGCCAGTGACACCTGACTGAAGCTTTTTGTCATTATCCTGGGAAAAGTGGCAGCTTGCAAGGAACATTACAAAGTGCACTTAGAAATTAGGTGGTTAAACTGTGCCAATTGTTTTCGTTGTTTTATAATATCATTTTCCAAAACTGTCCAGTAAGTTTTATTATTTTTAAAACTAGTTTTTCAACTCATTAGTTCTAGGCTGTACTCTCTTGTAAGCTTTATGATAACCACTTTAGTTTTGTGAATAATAAATTTTATTCTTTT 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@rCer/1269/25_1896_CCS ATGGGGGCCCTGGGCCTGCTGACCCACCAGCTTAGGAGCACCCGCCAAGCTCTGGGTCAACGTGGAGGTGCCAGGCCACCATGCTCAGTCTCAAGCTGCCCCAACTTCTTCAAGTCCACCAGGTCCCCCGGGTGTTCTGGGAAGATGGCATCATGTCTGGCTACCGCCGCCCACCAGCTCGGCTTTGGACTGTGTTCTCAGCTCCTTCCAGATGACCAACGAGACGGTCAACATCTGGACTCACTTCGTGCCCACCTGGTGAGGGGAGGCTCTGCCCCAGGCCGCGGCCTTGAGCTCAGAGGGGGTACCCAGGCGGGCAGGGACCGTCCAGGCCCACGGGCTGCAGCAGCAGTCGCGGGGGTCCACGGCGGCCTGAGCACGCGCCCGCCGCAGGTACTTCCTGTGGCGGCTCCTGGCGCTGGCGGGCGGCCCCGGCTTCCGCGCGGAGCCGTACCACTGGCCGCTGCTGGTCTTCCTGCTGCCCGCCTGCCTCTACCCCTTCGCGTCGTGCTGCGCGCACACCTTCAGCTCCATGTCGCCCCGCGCGCGCCACATCTGCTACTTCCTGGACTACGGCGCGCTCAGCCTCTACAGCCTCGTTCTTTGTGCCTGCCGCCGCACTCAACTCCTTCTTGTGCACCGGCCTCTCCTGCTACTCCCGTTTCCTGGAGCTGGAAAGCCCTGGGCTCAGTAAGGTTCTCCGCACAGCAGCCTTCGCCTATCCCTTCCTGTTCGACAACCTCCCACTCTTTTATCGGCTCGGGCTGTGCTGGGGCAGGGGCCACAGCTGTGGGCAGGAGGTCCTGAGCACCAGCCATGGCTACCACCTCTTCTGTGCGCTGCTCACTGGCTTCCTCTTCGCCTCCCACCTGCCTGAAAGGCTGGCACCAGGACGCTTTGACTACATCGGCCACAGCCACCAGCTATTCCACATCTGTGCAGTGCTGGGCACCCACTTCCAGCTGGAGGCAGTGCTGGCTGATATGGGATCGCGCAGAGCCTGGCTGGCCACACAGGAACCTGCCCTGGGCCTGGCAGGCACAGTGGCCACACTGGTCTTGGCTGTAGCCGGGAACCTACTCATCATTGCTGCTTTCACGGCCTCCCTGCTTCGGGCCCCCGGTACATGCCCTCTGCTGCAGGGTGGCTCACTGGAGGGGGGTACTCAGGCCAAACAACAGTGAAGCCCCATCCCTGACCCTGCCCTGGAGGGGCAGAGGCCAGGACCCCGTGCTGAGGAGGAGCCCAGAGTTGGGCCTAATCAGGTGGGGACACATCTCAGCTTGGAACCAACAGGGGCTGAGGAGAGAGGGCAGAGGAGAGGAGGGGTGTCTAGGGGAATGGCAGAGTGTGAGCGGGACTGTGAGGGGGCTCTTGATGGGAGTAGAGGAAGTGCTGAGGGTCTTGAGAGGGGAGATGCATGCGTGTCCAGGCTGAAGATGCCCCCACACTCTGTCAAGGCTGGGGCCAGGAGGTGTTGGGGTCCTTTCATCTGGCTCCATTTCTGGTGCTCCTGAAGTCTCTGCTCAGCACAGGGAAGAACTAACACGACTAACCTAGGCCTACCCCAAATGCTTCTTGCTAACCAGGCCGAGAGGCCACACACTTGCCCCCCATCCCCACAAACCAGGTAATGCCAGTTTGCCAGCAGCTATTTGCCTAGAGAGATGAGTCTGTCCTGGTCATAACTGTGTACTCAAGGTGTCCAGGCTTTTGGGGGTGGGCCTATCTGGGTGCATTGTGGATGGTTCAGTGGATTGAGGTGTGGGGAGGAGGGTCCTAGGCTAGAGGGGGGATCCCTAGTTAAGACTTTAGGAAGCCACCTTCAATGTTTTCTGGAACAAGGCAGGTACAAATAAAAAAATAAAACT + EI5JHIJJKKFJKKJIKIIKKK8KKKHKJKKKKKKKKKKKKKKKJKJKKIKJJ/KKKBGKKKKIKJ>KKKJKKEKKKKKKFJJKKJKKKKJKJKKKGK=KKJHKJGKJKKKKKK?EKJIJKJCIAHKBKKEKKEKKKKKKJGKJHKKJIKJ-KKJJKKKKDKKJKJKKKKKGKKDKKKKKKJJKKKKKKKIKKKFKKKKKKKJKKKKKKKGKKKIKKJKKKKKK8KKKKJKK-KKKKKIKKJ,KKKIKKCKKJKKKKKKKKKK;KKKKKKKKK?KKKKAKKKKKKK9KKJJKKKK?K>KKKJKKKI-KKKKJKKKKKKKKKKKHKKKKJKKKJKDJKKKKKKJIKKKKH;JKKKKKKKKKJJDKKKGKKK@KKKKKJHKKKKKKIKJKKKKKKJKKKKKKKIKKKKKKIKKKKEKKKKGDKKKKKKKJKKKKKKKKKKKKK%K@DKK?KKK+KJHKEIJHIJ5KKKGKFKKKHKKKHKKKKKFKKHKKKKKKKKJBK5KKKKKHK>KKKDHDKKKG7KKKKKJIKKKKKK@KKIKJBKEIKKK.KKKJKKGIKIKKKKKKKKKKKJKKKKKJKKGKKKKKKKKKJKKKKKKGJKKKKJJGKKKKK>KKKKIBJKK7KJ9KKK9JKKKK@KKJKKKKKKIKKKKKKKKKKEKIKKKKKKKKKKKKKKKKJKKKK:KKKKKKKKKKK:KKJKKKKKKK'KKKKKKKIKKKGKJKKKKKKHKKIKKKKKCKKHKKKK?KJKFKKKJKKKKKKJKKKKKIKKJK6KGD/IJKKKKK9KKKK2 @rCer/1270/25_2874_CCS ATGGGGGGCGGCGCGTTGGAGCCTCACCAGCAGCCGCCGCCCGCAGCCCGCGCCGGCTCAGCGCAGTCTCCTCGCTCCGTGCTCGCAGGTGCCTCCTCCTGGAAGGCGACAGCGGCGGTGCGAGGAGTCGGCGGGCAGCCGCGCGATGGGGCCCCTCCGCGAGAGCAAGAAGGAGCACAGAGTCCAGCATCATGACAAGGAGATTTCTCGAAGCCGAATTCCCCGGTTGATTCTTCGGCCCCATATGCCCCAACAACAGCACAAAGTGTCCCCAGCCTCTGAGTCTCCTTTCTCTGAGGAAGAGAGCAGAGAGTTCAACCCCAGCAGCTCTGGGCGCTCAGCGAGGACGGTTAGCAGCAACAGCTTCTGCTCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCAGATGCTGGAAACAGCCCATTGGCTTTTGCCCTGGAAGTGATGAAGACTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGAAGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGCAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACAGGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGGAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGTAATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCACGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGCCCTGTCAATATCCATCCCAGTTATGCACCCTCTTCCCCAAGCAGTAGCAATTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATGAGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCTCCAAATCCAGAGCAGTATTTGACTCCTCTGCAGCAGAAAGAGGTTACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCCCAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGCCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATTAAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATCCAAAACAAGAAGTTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGATTTTCCATGTGATTCCCCAGAGAAGAGTTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTTGCTGGGGAAGGGGTTGACAGGGAGCTACTGGTGGGAGATAGCATAGCCGATGGCACAGATTTGTTTGATGAGATGGTAACAGCCACCACCACAGAATCTGGTGACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAATGTCCTGCAGCTGCTGCCCATGGTCATGGGTCTGGAGGAGGGCAGTGTGGTGGTGGAGCGAGCCGTACAGACCGACGTGGTGCCCTACAGCCCCGCCATCTCGGAGCTCATTCAGAATGTGCTGCAGAAGCTCCAGGACCCCTGTCCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACTCCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCGTCCGCCAATGTGGATGCAGAAGTCCATGCAAACCGCCTCATGAGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGCAGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGATCCTGTCTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCATATCAAAACCTAAATAGAAGTTGTTGTTACTGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAGGTCGATCTGTGACGGTTTCTATTCTGTCGTTTTGCTCCTCGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCATGGAGACCTGGTTCTAGTAAATGTCCCACCAGTGCGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATCCTAGTGGTTCAGGAAGAGAAAATGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTGTGCCGTTTTAAAATGTGTAATCGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGGTTTGAAGAAGTCTTGAATAGCTCTTTAGTGTCTTACTTGGGGTTGATAAGATTTGAGTGTCTGCAATTTTTTACTAAATGTAGCTACAAAGTCTTAAATGGCTTGTTTGTTCTTAACCTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATATAGTGTTTTGTTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAAAGTTTTATCCTCC + 28$97658345306529592434,+4368355.038051,569963,7877179883786384766840455561+.4678:7545539693426;4045225;958.62*7:5:46968579(6/98-7:7-37:::6;88:9:28/431+634244582.9898558134:976289573449459.9:1/4&062.165939720/1.754:9./2.&,-411,613014481+1*1572403916873914:976944(794153.999-.+45+41132.&00%+4476524/96527922.4723.70//0809977:6467298/589:7:9:7:29158:96(6426479096658.83984299112283,.8.53363078598356637&+.1-'/--024466,,2266,431.,3963:535'31661$57563279+/08945552334544565.3.95,1114423&4/0,654.-0*.,051.11,(+*4.-.39;2-&1)'10359232:99:5956633.41549699.2320123/0/:033)/1,.254-..1,,-169759/-3443032-425/564236711/668:881:6+878:3986026349-/242678579362675/473739)./7393633751.46538-347,7224/--1246905453*65-2-421543479-/0)53+--(62,-/42.252.558/::577-:5/99:6:445555432-/0,)0/1031356/5573/,.5:2-811.929;8-336.1.44-264345%/,-005.2(0182//0-,65879.4;:95/35-568686648.21244869,(3+44502:51-,///./80202))'-230224-4.164-33*'.1/**-&-,48.-23925',523444:/869724-1$.777987;4758/45425/7430+43336)320/33623533/68959*63409277:/895495777.0,232/54381:7-:73687:8*34524246.698;6;62495847:8;19;:7:96:449904402:9:387:2:71:6674152-4$3.)/70592523/)7482-+)-.8360537;9:97:2879.+;79659-439%5+*28;989:289;9588'/+4201.08509897884419034579;467778:7(+74)-+363760856884;;6,7,9*5527073.13,818:79-14679./7:4177*83655/1.120'302442:13957::53;8+1.&/11-464:4-62-4423924462.0:/78877::59589(-/27+8845$3+28:9876-6459::5686;:408639419:711/22407458683737657.7525:.868.8876:3964:7238507>6?;/<9=>:=;483;25;/<;:8838;4)=>05)14065-<:5<:7>=?:69>3:95783=9<043;>>3<;8?9=;7:0&35816997*<30:.<;=99:==>6/:<>>:9728=7:,:4:79?>=;<7?=6,:9?232<279777<:727,6?:9<<:>77;=;95<9>>9<=3047/20263378:>62'89;83==>=;>3>:6289>;;<93:<=:886=4>:=1<;<=4;;2<85879:450:::=??=99?:;86;':678;69>;><>;>899=;=-554==379<>>=61?*:85777059898?;=<<9387;==-<9>;/9<8::9?<9<<6;4=>==8+99888957<=:<775:7==??<65?<.7-738;16(26228356<:==;080<>;:<2989=;9973=887;<<02<;89<3<5:9=<87193?:=<;83.9977/57:5,;=979<<979<;6:<:*947899:89=38==8=>-7<:>:>::96:9=917159525=5,:=:79=9=>82:5=?>;:>:888286:=<99=5==??:<<8=87<946<7:;9=;=>?>-:=;9?8=>8=>62<;=97:4;=<<97>46=6?99;=88>=892:=:=;;6):<==?8<9=:;8.6'8;<<=;2====>><8.:6*5=:<>>>89<>:>;=?:74<1+77:<<909993;8;9?:=+55;:3;68<;96<=8675=8<8==;:298<>6<969=/,169?=;?;8?=8=7=99;9=<8?;<>>=82(982=4-;:<<><>7<;8:5/9=7<3===66<.<<889=>=:>:;:9:<;/5.56>;?3:;;>75=9;<39985<3291;<=89:488<)84;88?;7:=9;<89<>:>9?><>7:?9724497>;=.=99>6>===>4;:-49>26<><;0;9:?9:>2:790*48/<977=6:>74:?<9>;:3853=:4>=8;>98597;+8>=<=8?=>>:09:;?;???1>9:;6;75*<9969;85139=:>*:==589:;/>9598.:=;<<3;;;536=6<<=:=86>5.89;:84672:9889==+=5=>=(8;=;;:;=9=?=<;>1>=7;8>9:17<95<<4:7%9;;;=;=43<79>7=<=:7<=?;=:;?5:*1=5>=8>79>==3=>=.4=<;:7>:><;.<95=:661'::55;6:8.8=78,11646 @rCer/1271/0_1990_CCS CGTGAAGGCCTACCTGCTGGGCAAGGAGGACGCGGCGCGCGAGATCCGCCGCTTCAGCTTCTGCTTCAGCCCGAGCCGGAGGCGGAAGCCGAGGACGCGGCAGGTCCGGGGCCCTGCGAGCGGCTGCTGAGCCGGGTGGCCCGCCCTGTTCCCCGCGCTGCGGCCCGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGTGATGCTGCAACGGGCCCGTGGTAGGAAACCCGCTACAAGTGCAGCGTCTGTCCAGACTACGACTTGTGTAGCGTCTGTGAGGGAAAGGGCTTGCACCAGGGACACACCAAGCTCGCGTTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGCTGAAACACGGGCACTTCGGGTGGCCAGGATGGGAAATGGCCCACCAGGAAACTGGAGCCCACGTCCACCTCGTGCAGGGATGCCCGCCCTGGTCCCACGGTGGAATCAGCTGCTGGTCCATCGGAGGATCCCAGTGTGAATTTCCTGAAGAACGTGGGGGAGAGCGTGGCAGCCGCCCTTAGCCCTCTGGGCATTGAAGTGGATATTGACGTGGAGCACGGCGGGAAAAGAAGCCGCCTGACCCCTGCCTCTCCAGAGAGTTCCAGCACAGAGAAGAACAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGCGCCACGCAGTCTCTGGCAGAGCAGATGAGAAAGATCGCCTTGGAGTCGAGGGGCGGCCTGAGGAGCAGATGGAGTCTGATAACTGCTCAGGAGGAGACGATGACTGGACCCATTTGTCTTCAAAAGAAGTGGACCGTCCACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCGCATCTCCCACCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAGATGCTGTCCATGGGCTTCTCTGACGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAATTACGACATCGGGCGGCTCTGGACACCATCCAGTATTCAAAGCACTCCCGCCATTGTGACCGCTTTTACCCACCTCTTCTGTGTCCCCCTCTTCTGTCTCGTAGCTGTTAAGCTAGTGTAGAATTGCAGGTCTCTGTACGGGCCAGTTTCTCTGCCGCCTTCCAGGATCAGGGGATCAGGGGTTAGGGTGGAAGAAGCATTAGGGCAGCAAAACAAGTGACATGAGGGGAGGGTCCCCGTGTGTGTGATGTCTGAGAAGCAAGACCGGTCTCCTGGGTGCTCTGGTTCCCTGCAGCAGGGCTGGGCCTGCGAGACCTGAGGCTCACCGCAGCGCTCCTGGCCCCTCCCTGCAGGGGCCACATTAGCAGCCCAGACATAGCTTGCCTAATGGCCTTCCACTTTCTCTTTTAAATGACTCGGAGGTCCCTGACATTTAGTTGATTTTCTGCTAGAGACCTGTACGCTCTGATTTTAGATAAAGGAAGCCTAGGTGTTGTTGGCGGGTAAGCAGGGGAGGCGGCTGTCCTGGCACAGGCAGTGGGAGGCCGGGGCAGCCAGTGTGGTGGGCTTCCTGCTGGGACTGAGAAGGCTCATGCAGGGCATCCGTAATGTTGGTTTCGCTGAGAGCTGCCTCCTGGTCTCTCCACCACTGTAGTTCTCATTGCCAAACCATCAGCTGCTTTTAAAATAAGATCTCTTTGTAGCCATCCTGTTACGTTTGTAAACGATCTAATTAAATGGCATCAGCACT + S0/536-2042100+46*-1/(/5231-5489:*49885:232'46477:5-77359345485742925'1*)/06304+40336,73.240)55-/4-74469557+66806250400-.*24)/+'0-/+1224512$-321414-59%('.1337,12/:,3+,3*,)*32-72:8:2*22)$'%$$'#,)0333-8.-025.0/.4;+5+/9:)6293:9;531)04548(28:833<>4@.9'?;)>>=.3.+01%/-,479=<:3678B56:3B>?&496<88;8:0455734035;7;4:70/57955/.5$,.:42:918>3?:5445;5.<);;5;0=A0661<=>=76==A2=A98:@98098>BC=?>=:7:7>?A;836?6>?'>@@CA7<;:+;;:@>>?5732579003388<773::=A08;8/9':8::=;-67?<7=>=437AA7>>2$=46::A::;476:95?:BB@C9@59:;:<5796695.8?@<%092==6(<>?:==>;8@?3>;0$=$1;?ABA=B5A=8@53==1085=9:88:99=:686;5%08.44*@5)*28758=2::<=2;629.06+639453=:366@>505762/584.3=;69@A8;6:;15884<<8;747%9.2.744212/%37/79::/86/<>;-3:704,5<<=/;@5@@B/6-'2'47;;?=A?5=B9>-?=/;)%;=89/>:1?;:<=6>(.356;.63:;34<4=3@>5;BCF@9@.A;DA5>5;?F@>:?@;2E7GEFA=68.A6:@.?6D<7<:;77;;=??B:FDE;CA9B?:5D?4%7;94;2=D:7?:D:@=B55A>?A8BD:97<9:<5A5B>::%=B-CFD;<=9:;A?4>A5;7=?7@C>C<;=D>CAGED@9?==.688C3??D>B=FA:ACAA6:C@=DAFBCEB8,@FE@;C=A2?2#?5689;81*-,7':8::B:7AAEE=3:399>(A2/8->9A%7,198;=A5CA877C>:47<>>@F:>5::7@=<5528<5>B<>C0D:82>80:,?@999-57-765@@<@<7>?A=+9242-31/6:56:<::?=:45.1.37/,@B:B>AC;8*<;<@:377962-8@:=2234-<504>FBGEA<;/0<6%968?>::56.)&8;9=;8:;<::69<>194=;:>?/@8?@?7:>96-72&9;.-6:49:<@4<7:>;9>>@4-9/5;<8A<5;?AB>;CDEFD@A4EG>GCD9CF@F?C9.>=@B<624E;ICFIB%?<;ACGF1CG?5AD(<444C$5%;6194@9@969F:25:=89A2E,@D?<*@<@FCB.=;B;7=D5,8@3;;<9>B=C8DDA7GGDCF>ECFJB=B;E8=>EB=;EBBC?(F@E8;FCDC@GB?F???C6GC>EIIH=3;3:;AE-4B<:;9B2<9259?;@6-@DAC:A7B@:AFGCB?EHAIFFJBI>0IF?8?=<>@=8@BEC5@?@>=<:C'9?AA@=A0FA><;@CF;E@C;>(:>(13%452777;2BC?@77.9=>,884A718@=3=5@:?@5,A=:<;<;;>B=BA====?>>1?<:77::;;4;BB4<-7,2?>9A@;A==ABB@:<=744+6246892<:-;77=<=<.093?>365=90@A9):88:=C=<6>A=1;;7>;34;A27<@>3@6440?C6:6B99-)9:;=C7=?HHKAKJKFIJJE,GHHIJB>1D,G5@A&68H-KK/HEJF&JJIHIIJKKDKG@C@?HEFKF:KHKECHKHI>BIGIJGGHKGKKK?KKFIJ9DKBKIIJKKKJJJJJKKGKJAKJJKIAKJKHJJKKG=K7KJJDIJ>IIJIJGKJJF71KKKKKIHJJJKFJJ8FGI?JJIJKKKKJFIKFI?IJE5IJJHDGBH<>@GIE7KKCAJJAJK>CDGKG:JGK@JIIEIGE%&C,IIEA=IJCEHJIHGIHKJJKJHIC-JGJJJEJEG2H?KCIIKFIHIB%H9F5A>KBJIH2JJI98JHE8GG?>GJJ'KKJCKH?EIGJFIKH5JJK4H%BJKIKJEK=G4KF@KJ@CHIGH8FH&HKJGIKHJJ@'KIFE?KKHJ5KFF*KKIKJ+KK-KKK7EBGCH+JIF+DIJJ>JG?2J/KFB'IKIE9KCJKGKJGGFI9F)D/=>B??KCKKHFJKJIKFKIIAJKC@::2>GEKHIJIIGKIJJ.IIBJKFIBIKIFA<2BB452=AHCCD@GEHI3G>EAGHJIKF@6BJKGJBIJ;IHIFDDAC?EK=KG53IFC5@EIFEBIG@?CBJK9@CHCEHFADDEEIJ@EJKDJ9K?FHIIFB9KHA@%FK=KF=>FBGAIIGG?G@IH2KGGED/GJ9:JI?KJCHA-AH2HEE@>KHECH=GA:AD@:B(JHGHF.?BG@GDJKJK5ICFHHHK1D=A?9CGH.:FIKHAHE>6<@'JGJJ>C@.J,G?,@/?HJH=HKC?&CHJE1EGJFEH3JIGB(E?%GGCE9DD>;BDEB?;IBCFCIBC>FBEGII;HD5JIIDEKID:JF=BBHBCE-BK1HEE1FJKBFGKJGAI?7E95?@8C?G@C(EB+CHDE>JJCGI685>IJIJEK1FDF6F;>7B2?5EEC<@FCHGDAIJDFAE?5I?ED6KK>KIJ9I?EHJG?<0HKBJ7KKHEH@=GK3ACD5CBIIIIKEA?D?HG*GC-2B$D@BFC79JKJAG:JKF?8:C<>;B9ADKHHECHB+JJ;DE=KI8+;59==JIIFEE'C9?ABIC9KJDH,KII=EEIG7HI8DE5HCGH*F:HEBFGI>HKKFH7FGG%FJCGH3IFFBIFJ><>.?C?F>I>FJJ3IJKAJ3IB;C%JIEEGIHI:+=G;K?JHK3KIH4@EHFA>GID?BJHKKJEHIBDIG%EDG;95EBDHGBIFE7AKKGI*54)GFJGJHKJI?17;7993617>6?E9418/;:/8@96?=BEAAGAAB6?===@=FCA=CE>EBD9E?AA@=<59>018@A>?3;@B6BCB2<0D@@2<,22?;695/:AEA@C:@4?ABA44:*8?8=D76A)C@05=0D<;6;:?D1DEA>A>=;<8B>F?7<2@,=;.0<=0@,BD@C/?;05468>=A<>?801=&918:A7AA6@5(8A3>;9=37&48>E3>:E2@8:<1>7%,+8171.1.2>2@284;2/6.%&')%-5660D?:<@=469?<7@3:4ECA8A2/@A@0<:2+3793-4A;>A<:0/0'13;6:5=95<.6-FA?@?<<8===G=C2::;;>:?>B6,1751424=?<>:;1-12=?:2:5;1-,63778<9>31858,6.377044;:=7@?;BAD??A9)=.3<<93CAF3;;9<4C<>6==<(+5<>994?>?=+:6-27945/:7194;534>89>7+96<87A9;7;<6=>:?EB0E6;3>GF+>>=@5;@=C8A:?=?AADA@A;E:@A=AG?A;>B<64&>/5-=<;5:5?5<;5<;<=@9*8&.7:/$55<=;>;>@8=9:)=5185:88.;.595<;:=;763--4<;9=*51-%.3:1:;9:=9><09=;5:@@>;=9>>;4?A6B66(1/149BA@::<.739<=45:4543666>?@12-::5<9-<'8452=3@A8::=<;CA:?72?AA75/75.89:=?<3=;87)85:<1:07>@+?;8><<6<<9/532$.85-?@?=<;9*5<5$=>=7&4958=87<;@9>?A;4<9;5=88:158245:=@445:9A1A><6(>:45:CB9@'694=>A=C@@6=77=:<&80<87<5;@>3>>8.;:.@79A9=>/?;?4>628<@9A)>>953686A'8<=?CB7><=5#48:71)'@76;?)0,.*.=;<$945<:<>:BA4;3<:+;8:4.:0=0:4@<==%<:79-;99=6?3>85:?5B<@8>>7@7=5666:A;<;773==9?9A@:7:>=4B;1718'877?<;:2595;34155+241053&043$76171/30/22,/+-'.'5-,+(/20021631.3.,/.91$817+0/34,/+241*,1358989:9/5159.:3/2.59/.)-81()14-0+783737)8972:0931549.6643)2*30/5-.4/19024+16.4/:446,68-71,-/-45372;://9,.''.&/5-4231469610.,356461.2&144,1-.44693).-1168+.006+1&%%+&,/+')4/.65..7*47,./7,4+2'5.+&4554078569890250.1./99399:1413-:&0.5.32333714+53/+6876/.5304330041+&0)233156)-.353134/4523*4,5357,#(*.-*0440323698::31247.-4225445)335094.-53474.,/2888 @rCer/1274/2423_51_CCS ATGGGCCAGGGGCCGCGTCGGAGCCTCGGCGGCCGGCGGCGCTTACACCTTGAGAGGAGCGTCTCGCCCGGGAGCAGCGGCGGCCATCGAGACCCACCCAAGGAGCGTCCCCCTCGGCCTCCCAGCGCTCCCAGGCCCGTTAGCGGCTGCGCCCATTTAGCTAGCTTGCTCGCTCGCTCTCCTTCCCTGCTGCCGGCTGCGCCATGGCGTTGGCGTTGGCGGCGCTGGCCGGAGCGGTCGAGCCGGCCCTGTGGCAGCCCGGTTACCAGCGTACAGAACAGGTACAGAATGAAGAAGAGTCTGGAGAACCTGAACAGGCTGCCGGTGATGCTCCTCCACCTTACAGCAGCATTTCTGCAGAAGAGCGCAGCATATTTTGACTACAAGGATGAGTCTGGGTTTCCAAAGCCCCCATCTTACAATGTAGCTACAACACTGCCCAGTTTATGATGAAGCGGAGCGGACCAAGGCCGAAGCTACTATCCCTTTGGTTCCTGGGAGAGATGAGGATTTTGTGGGTCGGGATGATTTTGATGATGCTGACCAGCTGAGGATAGGAAATGATGGGATTTTCATGTTAACTTTTTTCATGGCATTCCTCTTTACTGGATTGGGTTTTTTCCTGTCTTTTTGCCTGACCACTTCAGCTGCAGGAAGGTATGGGGCCATTTCAGGATTTGGTCTCTCTTCTAATTAAGTGGATCCTGATTGTCAGGTTTTCCACCTATTTCCCTGGATATTTTGATGGTCAGTACTGGCTCTGGTGGGTGTTCCTGGTTTTAGGCTTTCTCCTGTTTCTCAGAGGATTTATCAATTATGCAAAAGTTCGGAAGATGCCAGAAACTTTCTCAAAATCTCCCCAGGACCAGAGTTCTCTTTATTTTATTAAAGATGTTTTCTGGCAAAGGCCTTCCTGCATTTATGAATTCTCTCTCAAGAAGCAAGAGAACACCTGCAGGAAGTGAATCAAAGATGCAGAACACAGAGGAATAATCACCTGCTTTAAAAAAATAAAGTACTGTTGAAAAGATCATTTCTCTCTATTTGTTCCTAGGTGTAAAATTTAATAGTTAATGCAGAATTCTGTAATCATTGAATCATTAGTGGTTAATGTTTGAAAAAGCTCTTGCAATCAAGTCTGTGATGTATTAATAATGCCTTATATATTGTTTGTAGTCATTTTAAGTAGCATGAGCCATGTCCCTGTAGTCAGTAGGGGGCAGTCTTGCTTTATTCATCCTCCATCTCAAAAGTGAACTTGGAATTAAATATTTTATTGTAAGATATGTATAATGCTGGCCATTTTAAAGGGGTTTTCTCAAAAGTTTAAACTTTTGTTAGTATGTTTTTGCACATAATCCATATTTGCTGTTCAAATTAATCTAGAAATTTATTCAATTCTGTGTGAACACCTGGAAGCAAAATCATAGTGCAAAAATACATTTAAGGTGTGGTCAAAAAAATATGTCTTTAATTGGTAAATAATAAGCGTTAATTTTTTTATAGCCTGTATTCACAATTTTGCAATACTTTATTTACCTAAGGGATTCTAAAGGTGTTGTCACTGTAATAAAAATAGAAAGGACGAGGATACAAATGAAACTTAATTACTAAAATGTAATTCTTGACACTCTTTCTATAATTTAGAGTCCCTCACCCCCATCCCCACCCCCACCCCCCCCTTATTTTCCCTTTTATCTCCTGATGATTAGGCCAAAGGCTGGGAGTAAGGAGAGGATTAGGTACTTAGGAGCAAAGAAGTAGCTTGGAACTTTTGAGATGATCCCTAACATACTGTACTACTTGCTTTTACAATGTGTTAGCAGAAACCAGTGGGTTTATAATGTAGAATGATGTGCTTTCTGCCCAAGTGGTAATTCATCTTGGTTTGCTATGTTAAAACTGTAAATACAACAGAACATTAATAAATATCTCTTGTGTAGCACCTTTTACTGTAGATTAGTGCTTAATTTCTTGGCTTGCATTTGTTGATTGCTAAGGCAATTTTTTCTAATCTTAGGGAATAATTCAGTAGATGTGATTAAAAAGCTAATGTTGGATCAGGTTTTTTTTCTTCATTTTCAGCACAAGAAGTCCTCTTCTTTCATATCCTACTAAATACATTCCTAAAAAATGTATATGAACATTGGTTCTGTAAAAGATAATGGACTAAAAAAGTAGAGAAGAGTTGTAGAGATCTTAAATCATTCTGGAATTCCTAATTAGCTTCAATTTTTTAGACATAATTTTAGATGATTTATTTCCAGTGTTTTCTGCATGTTCTCATTTGTTCTTTTTCTCAGTTGAATGCACCAACTGGTTTGAGTCCTGTGAGCATTCAGTCAGTTGAAATTAAAGATTCCTCATTTCTC 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40.+%/,'/21+6+9812,58885222.0*3-%$3176768::/*--.)--3921:2469579,8377--+&3-5-,,,#.0/44./,((/-80426607/3,1446.8880,40:7;981++43898531,-*0+,&1-#0)79.9589/8;5:99+88873989351279347:5:87539690-22320402/345-1564365:5437524(21-55,42'.0+''-'%&)%'&,(3*00.&$"$',#)&'')%##%$$$/.')$"#$$$*)%%-/($%-)'.10112+7.)1129130110/&/+*03--31&3-,4/0*'..13/36'/5-,,$*1.-042.74&-6'1/63:3/%//01/(+2'1.4594,5)22.54.=633375*46=;8??5:549298884%/5:<.897$.,6-2-*260+789853/-8231)/426824.)82$(,42,::88/0-9/:43366,40,3662:<787845638:/307787>>;:8:86.0:460981,-.07(1-:+<6.254874/7114140;9?==:1;3::-4<96::+6;:;%84:<>3:36;?=25,767:6>:96:286:7,$377<>:578+.3441#84;4(/32:<&-4.5<::187844:89877868:59353)2641:7*5817178649-95:276.5(%67<54.;-42;0/07862580<369<3<;3//1*/25.20&>667045*3037*4,7816*78:<=;9-:74<94654-49=4826:/:961)4393;4588369:53/6599875456-+6<939:5,::;9:7;7,584;698;7>>:395<5.%/8,;,349=>9977756;3>9>76=6<8438<'>89:77;778=>?:>:9487+762576:0?798711.6<4+1:778=1<5:;7?579065)9602$9:(199)0668)583/4:88345/8585681,34,7+-%,8878::18/83287053'//-89899::+5689;54719:3/1'(895:57&86869681060597465/399046-+&6455(,-)'04257%98&:;29.6*55+-65620564624,)14352*,/$01445/044233,#20*55-020*2354/05/%'%)&55360*3'-3)(*4562655466221,/,20-%.2266362,+$26464.1505+56232&(.60--34&./(21/2651/3*(54*35203,1(452*40620/0*313*20*,4(+4)4)53.14355+4132220566.++541.$314242023/0/00/22-1+%)*500/5526666562+64652/2)305(5350/*--033%01*+4..41)14,/)-/1425200-1/40,0,526642-+1460.+0+1**))24563/)1313053*/31/1,+,135'+23*56226/5//+.0,3./%&4&43450156325636655655245*4(4+5343556561+52'-0260206,54554-265+00**)%$*.+544'555621/%,.2/533156.5544,5/3$0,-(1517815759598980698-+6%49454;97+.)54899)41;98:709::8566.8-6,9:34+3434(.5618.4:230:6452737815./:999277-37&96919(587:729203%*547:10.,(51'430&76::-79.51851&-54,432%6::8-63(32(4):3/1+,7368,7&416'9894405*42+.52-987,02+-+(/(6217.-56.574()2)&(45-09.555)89:.8;733330$344*260::6./85:::-28*447.-*7,/189*5+9:34$71390947;595754')73&36/%/)4/921(17377.,2-/1:665/9697'9983/41049189595225-0.2+719-9,6.7,1241,7:58,8-85&/056/29:138951-55946995/:586'4225,-2..0497...9601.52&359853&.34964:7/8)2543849;6371695597-1+3130,))$+%0/654-40088/3-0563949:35615:45500-39882942450964746748/90&536;896'4/+/6-16443-8%0/,2)21-8132,8:56353-4::97917.3.00-2202-,52-.153/0055/2574301.%2&.+*5),1-11/30*+*301414122613..19997:69-2;4')2&,%,.6:+6&;;5886+4-6614.2/79762677694'/58.4&;77.1.347226459196.5834/+9665*&)7.772,/':&694195741:6384:7622-39773681-54*./0+-0)&*11138964/512(001+715:3/827.7941882515667377*.(173251)/58;:22-%122,,959931423495,63&26,8756/2281,::35:993-964152'4166.5598775*2%%68)3-4+..,,4/-8:6651200.0%4466,06-3135535332241 @rCer/1278/0_653_CCS CCCTGCCATCCCTCCACCCCACTCCCTGCTCAGTACCTGGCGTTGGTACACAGGCAAGGACTGGCACAACCAAAATTGGCTTTTCTCTTCCTCTAATATTGAAGAAATTCCCACATTTCTCATTTGGTAATGGTTGTGCCTCAGATTTCTTCCAGTATTTTGCTTCTGATGAATAATTATGGTCTATACATAAAAAAGTAAGATTAAGTATTGCTGAATTTGCAGTTACGTTGTCGTGTAAAAGAGCTACTTCCAAGTGTGGTTACAAATGAACCCATGGAATGATGACTTCATGTTCTTCTCGTGGTTTGTGCCGTGCTGCTTTCCAAATATGTATTGAATTTATGCATTAGTCTGGTGATTTCAGTTCTGTGAAATATTTTGGGATCTATACCAATTAAACATTTATAGTTCTGCCTACTTGTCGTTCCCTGAGGCTCCATTGCTGCTTGGTGGCCATTCTCTGCCTTTATAGTCACCTGAACTACCACCCATCATCTCTTGCTTGCTTGAAATCTTGCTGAAATGTTCTCATTTCCTGTTTGCTGTATGGGCTCGGTGGGATGTTGTTGGCTCTGTTGTGTTTATTCACCAATTTGTACATTATTTGTTGTCCTTTACTACTGTAAACAGTAAATATAGTTTGGTATTCC + S&&+,,/(-%#)($0+'$#)+--,000+*/1+&)+%0)%**/$/+110-0/--2.-.&+--,+1+-.&)-,(11-&.,20+220.++.-+1.*#-1-0-1100(-+,%''00++(',,01/))+,,0*.0.),-(,+#'.),)+,*110-202+.-*$(%*-/)*(%*)**(,/*/))&,,0/,-'),,*+$+,&%%+,**,)+2/-.0)+/'*/+,,&').1.0**,-*)**('&)+/),0,)(*/)*/(0++)(0+11+.,,'-)/1,-/+'0,.112020+(/,&+/2-./,)/*''*.+.),0),0+)/*/)-+)&)*)..,0)/,*,,*-(%'$())--(-,($')+-))-,-(',(,))---,--,('$(())((+,*,+-,+*),((.,-)-'))+%#*&#+,%%-++)&)+,'##&'%(+)(--+,)*--,(,*()$(%%'$'$+(%)$''()-,*'+%'&**+)&*---'-)+$+&''&*)%(((&''&)*(*--+(*')&,()+-+),.-+#-),+(*(')&#$&*,(-,,$))()$)+*$*,+&)&#''%**+**#)+)'%$#()**()*&(&(+*',+%&,''*+*++*-,(*'&,*(*(&,+++.-'',,,+*+(*-,$'#%,+*'$&'+,-(('*($#( @rCer/1279/1774_62_CCS ATGGGGGTCCGGAGTGCGGGAGGCATGGTAGAGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGAGGGGGCGATGCTGGAAGCCATGGCGGAACCCAGTCCCGAAGATCCACCTCCGACCCTGAAGCCAGAGACTCAGCCACCAGAGAAACGGCGGAGAACAATTGAGGATTTCAACAAATCTGCAGTTTTGTTTTGGCATATGCTGGTTACATCCCTCCTAGCAAAGAGGAAAGTGACTGGCCCGCCTCTGGCTCCAGCTCTCCATTGCGAGGAGAGAGTGCGGCCGACAGTGATGGCTGGGACTCGGCCCCCTCAGATCTTCGAACCATCCAGACTTTTGTTAAGAAAGCAAAGTCATCCAAGAGAAGGCAGCCCAAGCAGGTCCCACCCAGCCAGGACCCCAAGGTCCACTTTCTCTCGTCTGCAGGCCCCCGACAGTGCTACCTTGCTTGAGAAGATGAAGCTCAAGGACTCTCTCTTTGATCTCGATGGGCCCAAGGTGGCATCTCCTTTGTCCCCCACATCCCTGACACATACCTCCCGGCCCCTGCTGCTCTTACCCCGTGCCCCTTTCCCAGGGGGACCTCTCCCATCCTCTCGAAAGAAGGACCGAAAGAACCGAAAGTTGGGGCCAGGAGCTGGGGCTGCTTTGGGGTGCTTCGGAGGCCTCGGCCAACTCCTGGGGATGGGGAAAAGAGATCTCGAATCAAGAAGAGCAAGAAGCGGAAGTTAAAAAAGGCAGAACGGGGGATAGACTCCCACCTCCTGGGCCTCCCCAGGCACCCCCAGTGATACAGACTCTGAAGAGGAGGAGGAGGAAGAGGAAGAGGAAGAAGAGGAAGAGATGGCAACAGTGGTAGGGGGTGAAGCCCCAGCCCCTGTGCTCCCAACACCCCCCGAGGCTCCTAGGCCCCTGCCACAGTGCACCCTGAAGGAGTCCTCCTACTGACAGTGAAAGCAAGGAGGTGGGCAGCACTGAAACAAGCCAAGATGGAGATGCCAGCTCCAGTGAAGGCGAGATGCGGGTCATGGATGAGGACATCATGGTAGAATCAGGTGATGACTCATGGGATCTGATCACGTGTTACTGTCGAAAGCCCTTTGCAGGCGGCCCATGATTGAGTGCAGCCTGTGTGGGACGTGGATCCACCTCTCCTGTGCTAAGATTAAGAAGACCAACGTCCCTGACTTCTTTTATTGCCAGAAATGCAAGGAACTGAGGCCAGAGGCCCGGCGGTTAGGGGGCCTCCCAAATCTGGAGAGCCTGACGGCACCAACTTTAGCCTGGAACTTCCAAATGATAACATGATTTGGGAACTGAGCCTCAGGGTCCTCAGCCTACCCCCTGGAGCTTGGATACTGTCCGCACTTCAAGGCAGGAATTCCCAAGGAGACTTGTTTGAAAATGAGTGTCTCACTTTCCTACCTATCCGTCCTCCCCACTCTGAACTTGAAATTGAACCCATTACGGTTGCGGGTGGGAGGCTGTCTGTGTCTCTAGACACATAATCTCTGTCTCTTGGACCTGCCACCATCACTTTCTGGGTCAGGATTGGAATTGGGATGGAATGGGACAGTTGTCTATAAAACTCTAGT + /15666-1*&5#(,-.164-03)/$)11-0'-8(07/-4'87%896370153/3135134978./35637(63-,4046352'25968,-3648/:6:89-4,04(66/5%3/36:5/69629386'783939-49-068-$+0520++-1'214,00'*/4.6322+4/%-023./(1::41.73488624/4/)6-3.1*9949499+849::,:;95628.87.65+2/571116,4<204=59:8<<9=89;56*%:-7-87/6/2;3=*?B>=6:6@9?CC;?>0:C<01;:;;206<>&6:BC-:/?<>3:658:/>85933=508A8?><@=<152>5CA.B>@A???8:B+6C4A<=C2;:9;@<:B;@@<>?:A@?2476,0=;<8BC?8;.C:?@A8:E6GC?CBA%><8AC4D8?A5AA@5@99@7>DB>;487:;:';7:==.;A=C48=>*39?=7A;7==8;835@>,$=%56&?C5A>:@<;(=7:6;=78:0@376&055;#01765B64-=1/8;7711/461:7;&:67;*;77647:.37<-<,47:(::4C?28;>?7B@56A28.=.(96/118A0?8=>7:;<769%>?4@1?7:@/<>;0889&A:8C?3=>;@A-@?9;76=<$;7@84#7>=A5?>8:<=:87-?:59:;<1;+'56;'5;8%66;13:<1;:/7198B6@*9231>06:E.F>DBAC478B8:EE;>E??<::C/EE3;BF<>=6:029>A@&?@>>-=<<:9>=+7;86;DBCC2B@0C>7:CC7@5@?FD,?A/D>A>5?'8@FDAA@A?FGGE>DC?9F5:?>AB9B6,BB,B7A?=AC;<*;7@:@DA>;9?>@;>02-01>:&7.B1?CB?%?0DCB*;AA>6+A>1B1<>:289;$?FG3D1;@C0E0@BAC+EF:EC?6<@=/9?E6>><8'286%=;<4-;=:8ABA?C.A2==FEC:D2A?@BDB;8@D::889B1AC:7=.=<86@C>7'?BA<>=?DA2ACBA@;3;B;<@C5C<9=FCEC:@CC8;(>B=?7BBFB:<;<.77'@77>%;>,4A,>CB;;?==7?EE:?C46,98+?A?=93?7,8=>B11A8:6A9CA9D;CB+:%@@<>::;$:3BC8A/?EBF3?@?9?(?;9BA:CF;=;7A?CAD79/CB2>-;>>C7C;AC@@=?3:+3?<;C@2A>;CC5EAC=>B4F:A$?DB@74<6?,BCB@8C@=4@?AE2CEE/:5?>4>A3CC:9BCBD-@,A==0?>08@B@<@A>7=B:8-46>EFGEG6@A>48<@ @rCer/1282/25_2803_CCS ATGGGGCAGAGTCGATGAGTGGGAGAAGAGCGAAAGCGTGTGAGCAGCACTACGGCCTCCTCTCCTTCCTAACCGTCGCTCTCGCGGCCTGCCTTTACCCCCCGCCTGCTTCGGCGCCCAGAACACCTTCCCCATGACACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTGGCCTCAGGGTGAGAAAGTCCAGGCCATGTAATATCCTGGATCGATGGTACTGGAGAAGGACTGGCGCTGCAAGAACCCGGACCCTGGACAGTGAGCCCAAGTTGTGTGGAAGAGTTGCCTGAGTGGAATTTTCGATGGCTCTAGTACTTTACAGTCTGAGGTTCCAACAGTGACATGTATCTCGTGCCTGCTGCCATGTTGTCGGGAACCCTTCCGTAAGGACCCGAACAAGCTGGTGTTGTGTGAAGTTTTCAAGTACAATATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATAATGGACATGGTGAGCAACCAGCACCCCTGGTTTTGGCATGGAGCAGGAATATACCCTCATGGGGACAGATGGGGCACCCCTTTGGTTGGCCTTCCAACGGCTCCCGGGCGCCCAGGGACCATATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTACCGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGACTAATGCCGAGGTCATGCCTGCCCAGTGGGAATTTCAAATTGGACCTTGTGAAGGAATCAGCCATGGGAGATCATCTCTGGGTGGCCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTGGAGTGATAGCAACCTTTGATCCTAAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTTGCCATACCAACTTCAGCACCAAGGCCATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGGCACCAGTACCACATCCGCGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGCCTAACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGACCGTCGCCCCTCTGCCAACTGTGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTTCTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCTGTCAAGCCCCTCCTAGTTCTTCATCCCACTCCAACTCTTCCCCCTCTCCCAGTTGTCCCAATTGTAACTCAAAGGGTGGAATATTAAGGTCGTTTTTCTCATTCCTTGTGCCCATTAATTCTTGCTTTCTTTGTTTGGGCTGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACCTACCCTCCTTTTTTTCCCTATCACTGAAGCTTTTTAGTGCATTAGTGGGGAAGAGGGTGGGGAAAACTAACCACTGCTTCCATTTAATGGGGTGCACCTGTCCAATAGCATAGCTATCCGGACAGAACACGTTTGCAGGAGGGGGGACTTTTCTTCGAGGTAGCTGAAAGGGGAAGACCTGACTTCCTCTGGTTAGGTTAGGACTTGCCCTTGTGGTGGAAACTTTTCTTAAGAAGTTATAACCAACTTTTCTATTAAAAGTGGGAATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTTGGTCTCTTGCTTGTGGGACTAGCCTGGCTTGGGACTAAATGCCCTGCTCTGAACACGAGAGCTCAGCATAAACTGATGGATATCCCTACCTTGAAAGAAGAAAAGGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTATATTTAAATGTAAAGACAAAAAATTATATGTATGGTTTTGTGGATTAATGTGTGTTTTGCTAAAGGAAAAAACCATCCAGGTCACGGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGAGTGAGGGAGGTGGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATGACCACTTCTGGTTTCTGCCCTGCCCACCCTCTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTAGCAGTCACTTGATCTCTGTGGCTTTGGTTTAAAAGACAGACACTTGTCCACATGGGTTTAGAGATAAGAGTTGGCTGGTCAACTTGAGCATGTTACTGACAGAGGGGGTAATTGGGGTTTATTTTCTGGTGGAACAGCATGTCACTAAAGCAGGCCTTTTGATATTAAATTTTTTAAAAAAGCAAAATTATAGAAGTTTAGATTTTAATCAAATTTATAGGGTTTCTAGGTAATTTTTACAGAATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGGACAGGGCTGGAGTCAAAACACTTGTAATTTTGTATCCTGATGTCTTTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTTATAATAAGAAATAAACCCACCTTTATTCCTTCATTTCATCTACGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGGTTTTTCTCTTGTCATTGACAACTTCTAATTGGCATGTACAGTATGTTCAAAGTCAAAATAACTCCTCATGTAAACAAACTGTGTAACTGCCCAAAGGAGCACTTATAAATCAACCTAAC + '(&$%%&()((%%&($&'%$%'''%')((')($&&'($%#&'$)('#$$''"$$$%)'())&'&'$'#%&#$%'#%#$$&(&(%$#$#%#'%&%))(%&##%')())(#%%)'&(%#&%&)()((()')#&"$'&((#%')())()()%''%&("%()())%%&&#&%'$%()%(&'&&()()(%('(&)%#'')%($$&(()))(%%'%')%$&')(%((%((((%&#%%#'$($#$#**$(,,,((+%+',+$#'+-*,&')*#$$,,*--)-))*-(,,(()(+(++*-,##)+++).()*(&)-,',(+--+$,+-#()*,),-,)),&*--,-)(,,*-+,(%)(#'',-()+,,,$()*,--+--*&'(**+)----)+,,$)($(#(-&+%##"$&&*)***,*+-(%)*+)-+,.,(&'((($&*+,,(+-)#(+*)(,)+)(##"""(%(*(,(-)+,*),*-))(,)-/++)1/&+0.+11/'.($(210-0,&+&-/0-20*-+.+.*,0*0,&0/**',$00.(+*/1-011-0-/,0-/,0*/,,+//)1/*,+,-01%/)+-+%,(-%+))0+//200+'(++./#--'%--',*$$)-+*'-1,.2,1/+1.1./&.1''/+11.,11-,..,,&&'-0,02&%$../0,-/-,(2./2*2/-))((,).-,,*-/*1*++**+*--,-+0+(,-01.)$0,&(#).0-%,.1.-./0)'-211-.-,.,+1-%'&+*)%*,(002//2+1,.+&&,.)*&-,-$'''#*&(.+$01/*(+.'+*((*%*-)0(.,1111.2+-,0/-1.,*-+)/,,/./$++2/0-+*,*(..10*-*+-01+*''(,.-00&+/2-%%(,1)-.-**&..1./0,+('&,&**.)"'+110-,-01.-.&-,1,+)&(((-//+(,,,*/'*,+)+((#(-1+))*')*'*-0-,&&*,+)+0/-02.1..,-$-..*.*0/1.+-11/+-)0/''+)-.,.(.0,.,.2/,0,/+-1/+%-+,+.-,011-/..,-)%*(%**'&*-.00+1.12.211,)%(0**-).0,,.++,+.(+,),&-(,)(/()+)'%-(+/+,)*,+.($(/01-.-*.0#*%'&)-*(00()++-)-+(-1-&+/-,0.()*,0//*)+)+$,-*1-2-*+'+'),1,&,.-+(+,++0*/+*.'/-*/*/*.)/*/,+)'$(+,(*&()'(('//+),/,/1-('/0)()*+,-+.%*-00)$*0-/&/+*,'0,-.1,()/&,,),*.-,111,*.,11-1.-0+00-221,+%*&,***02(0/&*()+,'21.0/1.%+-/21/1-(/..-*1-&0,+-20'-%)0/2-,-..&,.(&'0-*-'+,)1%+-&,(*$.,0#&&&'%$$%'#$%&'#$$$))'(%*)')$)()%%,+++*(,(/-(().-00-/00'+0.+%,*-'+)*-0/.-.-'./-01-'$&%)01.).//./-.00-,0,)+&,+%%(%-*'+*(/*)#)$&$%*&#&%%$)+(),00,10*-+&00/*,/-.,111)/*+.&$&+,.011.1)1,1.,+/,+1/.))00-.1,0&%*.+(+.,+111/'+/1++)((*+01/--&..001(---//,(-.%+*,.0-020/202-+.))'1/*--,0',%0,%+$'()$0/+)(-,1---00001-/-0'10,++.00-+,%()*11)02*1021-.*,'.,/%,&+(-.-*/.0.&,,111*+-,,-*,0.,21(/,+)/-2.0)0+-,20&/0--,/.-1//2).-),-'00-*'--,./,-00*&-/,-+$***)*%)+.0(0))--+/$1/)/*/.2,/*/*1/%,/00/0)/100210../,%*-,-0120$)+)'0/22.+'')&+'+1-,*+$/+*/.)&-..++.$(*-)0,.11/21(*+(),00.-')/(*00'&+,)./-/-)-(,,$').-/+,(-.00+0+1211&-/010).&++1*02101*&0/+*+*.011'0,/',-.,'/00-%02&*'+,*,$010/01&*-*).--/0.0&--,+%&,)+'(,,,00.1101,,)'//0&,/-1//0**%&$%(011/0+&.)0.0.01&+10..#+*'$*%,/%(,*/**.(/..++/.-,+00*&'101022521//1.)513)3/,-),(&0//3(,)0/.132///0021/4./'3./4//2/13$1.211410)1015-04.4230--6-&'0314053'142536*./5/664(31&34552*3(.13'///,1).(0.230%-./*32.#/'('*',/2/20#/*5514/1043+,(('33.4341,5-3244/-1*4/66&1++3-&/242354$33.),-'%$()-,--1232156/60-+0-'401-,%-./6541+0/1)'$+//135.0'.-411*35/010-00640/135+&-01/-534562,006145134.302662%.1156.%16153.-3630/--43).23353110-15.350122#'+)0./*0/*-,.-(*)''/0-/-$./.-,-.(&+&,,///./*'&$(*&$*-)-.+--#.*/451413/204.1++-)*$/)33-.--/..-,))24/1/2/)5/.652.21445444/26&/.1-0)++0-+)1'%$2511504355104)03,/1320//2514162&0/.14'4232.//'-0.0(%,*(./)&-,'')..--.*-/.20&*)*)(1-1)%//0)101/,0+1,'0) @rCer/1283/2220_60_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAATCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + DHJJBCJJDIDHGKDKEKKHKJHIHGEFFGIDJJHJKEG=>:DIAGFJGGGIJC?H;7CK1IJJKBKKKKKKIK@G;JJJKDKI=HIJDJDIE?IKBHEG;H.IKKKIJKGEKBEIKKIJJBKAJKK>KFJB7EKIFKKKKJKKKEJJGK@KGJCHKKBJKGKKGKKJJIKKKEKDKCKK0JIHACDHJDHJKIKJKKIJKJKKFF@KHKJGEGHGI5J8KJHII@KIGKGGDDI9HK=J:5CKIKEKHJEKKJIIEFJCKJKJDJKHKKJJEIK@KDKKIEKKKKAKKKDIKIHAKK9IKJ9GHIK@KJKDKKKBJHDKJHGEKK?DIKJIHKKK+?8HKHKK2KEJKJ*KIKKIJKKBHDJGGGK@@JCAHIIJKCHKKBGEGFIKK8?JK4DKIKGKIJK)FK0GK6KK@&"EJGHKJKK2JKK5HKIHJKIDKA?FIGGIKKGJB:BFJJGGHDJAKKJIKKKKKJJJKJGDIKKKKKAKKKFJGIJKKJKGIHKK-IKAKKHIJKK>KJKKKKIKJKJIKHHJJJHEFCJCJCKJICFJKKKCHAKIKDKKF@K;FKJ>IJC@GKKKJ1FKFFJHKKJJJJJFKKIKKEJGGK@GKKJKKKKIAI7CEKIKJKKGJKCJKK?HJKJIKHKIKK@KJKKJKKIFGKKJJHKKJKKKBKKKK-IKGGKJKKGKIJKCJKKJKKJKCKEJKKKKKKKHIEEJKKBKFGFKB@JKKKK.JIDGJGKJKHKKJGGK=KHKKJK=KJKKKKKKIKJKIJJKKKAIKEHKKKAEJJKKAIK>JKKGKEKAKKKKKIKKK=JIJ@JJCIIK@JIKGJKKCKJJKJIKKKJAKJIK-CIJIGKI?JKHJKJGKIJ=EFJKIAHJKKGKKCKKKKKK9KIJKFICKIGKKKGJKCKJKKGKDJIIK:JKD;JKKJGDHJKKBJFKKJK1IGKGKJIKIGIEJKKK;KKKK2JEKJKKKIJ8K8CGK>KEKIJKKK1KHJ<@A;GGJKKFKKK-JJAKKIGG5HKFKJKJKBJIKKKBI>EKJ=KJ-KIKJGGHKJK;KBFIKIEEEK?KFKGHI4KJCKKKIG7JKHJKKGJJFKKBJIAG>DH?HJDFIKJHHGJKGGCBJJEJKJ?JGDGIGHGGECGFKHJHIJHJDJK3HJJIJKFHGJD@8IHKEKIGEGAJIKH2@GKDKJHJAHHH?JFJJI?EEKIJICIII;JAFKHIGIAJBJDBG=IBKJJF;CKK=JGAIJI4IFIKIDKG@E?BEG.IGIHEJI:J@JJ:JDKJIGJ>IGF:IK>FICJIIBIKII8KEF:CC8GCHKJDHHGD6FIIGKK=BKJHEIFIK@ @rCer/1284/1950_56_CCS ATGGGAGACTGCTCGGGTCAGTCGGACGGAGCACAACGGGTCCCCGAATCCGCCAGGTCCCACTCACTCCCGCTGGTCGCCGGTCCTGTAAACTGCAAACCATAATCCTGTCTTCACACTGCAAACAAATCACAGTGGAACTAAGGGGAACTTAATTTACGGTTTCCAGGTTAACTAAGGTCTCAGCTTTAAACCAAAAGTTAAGAGGAGACATTAAGATTTTCATTCTTTCTGGGTTATCTCCTTCCTGAAGAGCAATGGAGCCACGTTTAAATGGAAAAGGATTAATCATATCTCTAATTTTCTTCCTGTTAAAATTCTCAACAGCAATTGAAATACCACCCTCAGTTCAACAGGTTCCAACAATCATAAAACAGTCAAAAGTCCAAGTTGCCTTTCCCTTCGATGAGTATTTTCAAATTGAATGTGAAGCTAAAGGAAATCCAGAACCAACATTTACGTGGACTAAGGATGGCAACCCTTTTCATTTCACTGACCATCGGATAATTACATCTAATAATTCAGGAACATTCAGGATCCCAAATGAGGGGCACATATCTCACTTTCAAGGGAAATACCGCTGCTTTGCTTCAAATAAACTGGGAATCGCTATGTCAGAAGAAATAGAATTTATAGTTCCAAGTGTTCCAAAATTCCCCAAAGAAAAAATTGACCCTCTTGAAGTGGAGGAGGGAGATCCAATTGTCCTCCCATGCAATCCTCCCAAAGGCCTCCCACCTTTACATATTTATTGGATGAATATTGAATTAGAACACATCGAACAAGATGAAAGAGTATACATGAGCCAAAAAGGAGATCTATACTTCGCAAACGTGGAAGAAAAGACAGTCGCAATGATTACTGTTGCTTTGCTGCATTTCCAAGATTAAGGACTATTGTACAGAAAATGCCAATGAAACTAACAGTTAACAGTTCAAATTCAATCAAGCAAAGAAAACCCAAACTGCTGTTGCCTCCCACTGAGAGTGGCAGTGAGTCTTCAATTACCATCCTCAAAGGGGAAACCTTGCTGCTTGAGTGTTTTGCTGAAGGCTTGCCAACTCCACAGGTTGATTGGAACAAAATTGGTGGTGACTTACCAAAAGGGGAGAGAAACAAAAGAAAATTATGGCAAGACTTTGAAGATAGAGAATGTCTCCTACCAGGACAAAGGAAATTATCGCTGCACAGCCAGCAATTTCTTGGGAACAGCCACTCATGATTTTCATGTTATAGTAGAAGAGCCTCCTCGCTGGACAAAGAAGCCTCAGAGTGCTGTGTATAGCACTGGGAGCAATGGCATCTTGTTATGTGAGGCTGAAGGAGAACCTCAACCCACAATCAAGTGGAGAGTCAATGGCTCCCCAATTGACAATCATCCATTTGCTGGTGATGTTGTCTTCCCCAGGGAAAATCAGTTTTACCAACCTTCAACCGAATCATACTGCTGTGTACCAGTGTGAAGCCTCCAATGTCCACGGAACTATCCTTGCCAGTGCCAATGTTGATGTTGTGGATGTCCGTCCATTGATACAAACCAAAGATGGAGAAAATTATGCTACAGTGGTTGGGTACAGTGCTTTCTTACATTGCGAGTTCTTTGCTTCACCTGAGGCAGTCGTGTCCTGGCAGAAGGTGGAAGAAGCGAAAACCCCTGGAGGGCAGGCGGTATCATGTCTATGACAATGGCACATTGCAGATCAACAGAACCACTGAAGAAGACGCTGGGTCATACTCATGTTGGGTAGAAAATGCTATAGGAAAAACTGCAGTCACAGCCAATTTGGATATTAGAAGTATTTTTATTTCACTGTTACTTTGCATGAATTGTCACGTGGGTTCAGTCTGTCTTCATTTGCCCAAATGGAATAATACAGTTTATGTTGGAGTGCCT + 9?9:'?=<4>B>>6A9)@.@B@*CA@AADBG7>>>01?BA=:>BC6@B8C;4>B78<58>;DA?B;8F32<6===@BD@E4BDE=@A?@>E?FEE@E9?09CA@BAA?A0EF9@:9<<%AFCG:?=B5?7?BEGB@?;B=>62-9;C?>AB;A>2BE:<@C4;>9=A5FC@@@@EGG7C@@C>DCB3>B;D@>CB?:FFD4:F8;*4>>*9><3A&6:?>;<>B?;7C0>C<289B::=;*??4E:;?B3C?A@C8>4C3>:';E;7=FD.B>CA>CDF5?@A6B68B6;C>CD2DC/DBE=9?>CA>>B=A7A<5>D=GB??;EA1DBC9?A8;A>?>+@>@A3?7@7G?>?0GG@CFD7@E?D8D<C4BED=9>>=:B@6=:BGAA(6@C>@7;@>0?3B2@7AA7<=88=BC=G/=:B;BB?A=9=CDA;CF<>?*=@%@CFDAA?E:FD?6DEBEGC;=CG8A9DE4?.?AC5>D=>AA@:A5@BF6:>?:)?A35>:BD4A55*;=?2@BAE<;6=>,@A=9@A4B>6?7=.=8=<9C4:6@@@@@?59?:?62;;;737:=<<:3993<6;@;04.8-,>9?<;>)6/15;<;8;79<<28;68>3<==@?B@8:=<%?<6@:<;)>?54<2@??@78@BBC;97,50B28/78?3?4@B;BCA@=;@;A?C@461B0<79=B@2=2A9A?AA:;38?>?;??>3>/@?16>@9?@:4(398<*-;/;726<;=98:;37/84:337235/,0886:8>987::9>9>24<+=?<89=6979<.5.=7>?&:490<7><:;3491585;9&76,10'734=8<;;=9848.819:6>0<=>::2776::8$:1<935)5298?:9;=<60'6<5)45<<7:29883(6722-45><8;9?=5,78<*9?:;=236::847;441/.-10359*=96915657--3+3=987><8143746:;;2;;1871>8/;3<41;7:6+78:75766(51923+74'803-2-25072.5+34;65:874//*41'-=>>=576178725/-3839<76>;::69/7:62;;;7=;76532:<9/330)5569/=923616939:;9>:;<1.475243,..,36:==870123386*8%=76/:8737798//:>59=7/''5+6<7/612=99<=3:?6=1:74622;96336?5=7=79.284;9<:2.319-7;690)2689?;10+7)086<829;5;89:3>:=>>97.2;50;9?:81/4571:::.447&8318;65873/0<8;6015-76)86;;;87(/049495:231768:0;7787659<6106.7//823799;817<<3072943.*373.051429*+:4992:393/44254157815528<9736<1:650&4//71<6:877%:681427.7:*//-0*1(245519>=7516/06?:/=994>;?>654,/,4,*57=6=;8252490790685549;:35:67672694-3,18'45599:.;:8%)210+9697,:87(-519::7:;6:68?5<0/,/:86;<324889=;+83=1:693:80..==395779<8>-3,49;:-).%62498379=:0;277:=/6971=2/18+85;115.7:98<(:;7:23,+*91738 @rCer/1285/3007_74_CCS ATGGGGAAGCACCTGCGCAAGCCCCGCCTCCGCCTGCAAGGATTCCCCGGTTGCAGGCTCCGTGCTGTTGTTGCGGTGAATCTGGGGGCTCAGCGCGCCGCGCCCCTTGCTCGATCACTGCGCTCGACCCCAGCGCACTATGCGCGCGGTGCCGCCGCCCGCTCAGGCTCCTGCCGCTGCATGCCTGCTCAGCGCTTCCTGGCAGCTCCTTGCCGCCCGCGCCAACAGTAGCCGAGTTCCATCTCCGCGCCGCGGCGGCGCGAACCCTGATGCGCGAGTCGCGGCCACCTCCCGGGCCCAGGGTGCCCGGGACACTACTACGACGGATTGGTTTGGGGCGGCGGCGCGCAAGTCGGCAAGCTCCAACAGGCAGGTGGCGACGCCTTTGGTTGACCGGCCATTTTCACACCCTCCTTCCGCGATCCTACCCACCCTCAAAGGCGGCCCGTCGCGCTGCGTTCACCTTCACCACCCTCTTCATCTCGGCCTGCCTGCATTGTCTTGGCGTCTTCAGGTCAGGAAGAGTGTTAAATTAAGACCCGCAAGTATGATTCGATCATCCACTCCAGCTGAGCGTGTGGAAAATGCGCCGTCTAAATGAGTAGGATTGTTATTCGAGGATGAGGGACTTCCAACAGATTCGAATTGCAAGATACAAGGTTTAAAACCTGTTTCCCAGCCCTTGTTTGGTCATCCTGTGGGAAGTTGGTCATGCTGGCACCTGGGTGGGGTGTGAAAGACCTGGAAGCCCTCTCACGTCAGACGGTGTTGAAACCAAAATGAAACGTTATGTTATAAAACCCCAGCTCCATTGTGCGGTGTCAGGCATGCTCAGAGTGTCACTTGGCAAGTCGTTTCCACTACCACCAAACGTGGATTGCTTCTGTCCACCCTTGGGCGCCCCGTTTAAAGTGTCCCCCACTTTTCTATCCCGTGTGTGAGAGGCTTTGTGCCTTTGCTTACGGAGCAACAGGTGGGCTTTGAAAATGGTTGATTTTAAAAATAGTTTTTTAAGACAATTCGTTTGACCAATAGTAAATAGAGACCTCAGGAGTGATCAAGATATCTATAAACAAGCCTTGTAGGTATGTGTCCATACTCGTGTCATTCTTAGAATTTCTGACATTCTTCTTATCTGATCTAAACATTGGACCCCTATCTTGATCCTTTGCTGTTTTTGCTTGGTTCAGGTCTGGCTCTCATTTGGCATTCTGTGTCAGATTCAAGGTGGATGTGCTTAGAAGCTTGGTCAGTCTCCTTCGGACCTGGACACATCTGTGGTTCCTTTCCCTTCCCTCTCCCTCCCCTTCCCTTCCCTCCTTCCCTCCCTTCCTCTTCCCTCCTGCCTTCCCTCCCTTTCTCTCTTTCTTTCCTTTCTTTCTTTTCTTTCTCTTTTCTCTTTTCTTTCTTTCTTTCTTCTTCTTGTTCTTCTTCTTTCTTTTCTTTTCTTTTCTTTCTTTTCTTTTCTTTCCTTTCTCTTCTTTGAAAAATAATGTTTCAGCAGGAAATCAGCTGTGGCTTACTTCCGCGATTTCTTAGTATCAGGGAAAATAAACTGTGTGCACTTTTCGTGCTCATGTTGCACATTGTGTGATAAAAAGTTTTTCTCCTTCTCTGAAGGAAGGAAATGCAGGCAGCGTTGTGATTTATACAGCATTCTTTTGTCTTTTTTGTTGTTCCTCTGCTCTGTCACAGTTACCTACGTTTGTTTGCCTTTTGAATGTAATTTTTTAAAAACCATTTTAAGATGAATGGTGATTCAGCTGGCTGGAATAAAAGCACAACTGTCATGGGGACTATATTTGGAAATGTCAGTTCTGACTGGGGTCTGGACTGATAAACCTCGCTGGCACCAGTGAGGCCCCCACCCAGGACCCAGGAAGGTCCTGCGGGAAGGGCCAGAGGTTTCAAGGTGAGAGTGTCTCACCTCTGAGCTGGTTTGAAGTGAAGACTCGCTGGTGATGTGCACCCAAAGATCTTGCTCTGGTTCCGAGACAGTGGCCTTGGGTGCTGACTTCTCAAGGTTGATCGAGGCCTCCCGACGAGCGGTGTTCCCAGTGCTAGAGGTGATTTTGGCTGCAACAAAGGACGCTTCTTAGTTTTAGTCTATTGCAGTTGCCTTTGGGACCCTGGGATTTTGCCTGTCTCTTAGACAATGTGTTTTTTATTTTTTTATTTTTATTTCCCCTTTTTTTGGCCTTGGCGTTGCTCCAGGGTTTTATGTATTTTGCTCTGTTTATTGTCCTTGCTCTCTTTTTTTGGTGAAATACTCCCAAGCCTTTCCTGACTCACCTCATCTTCAGGTTCTTTCTAGTTTTTCTGAGAAGAGGTGGGGATATGTGGGACAGTGGCCATGGGAGCTCGGCAGCTCCACCTGCCAGGAAGGCAGTCGTCGGCCGTCTGCAGGAAAGCAGCAGAGCCCGTTGGGATAGCCCTTGGGTGAGGATTGGCGCAGCTGGGCCCACCACGCAATGGCATTGCCAGCCACGGGGCCTGTGTAGTGTCTGGCTCCCTTGCATTTCACTCTTCTTTTGTGACTTTTCCTTTTCTTCTGTTTCCCCCATCTGTTTTGCCAGAGGGTTGGGAACTGGCAACCAGAACTAGCCGTGGCTGCTTTATTCGCTCCCTCTCCACGGCTGTACTCAGGCCTGATGGTGACTCACGGGAGCCCAGCACCTCAGCAGCTTGTTTCGCCCCCCTCAACCTTTGACACTGGAAAAACTGCTGGCTCATACAGGGTTTTCGACCATTGTCAGTCTGAATACCTCATTGAAAAGCTGTGATTCCTCTGCCTTACGCGGATAATACCACGGCTTCCATTCTGCCAGGTGCTCGCCAACTGGTCCTGGTAGAAGTGGCAGCTGCTGAGAGTGACCTTTCCAATCCTTGTGGCACTTCAGCACTACAGGCTCTCCTAATAAACCCTTTAGATC + &--''&*%.-.-(#'-.**'#&$"&-''-(%/(../(-,/+..(,'%#&#%&-&-(',+&-'..-)-($-)%.+.&#+&-//.+&*)'.-,)%*,$+$+-*,'$))+%',#,-$)'#%)(-.+%,.-&)&)-#(/-.-*.))-.,.&'*-.+.'*-.&-)-%+&..#.*,../,.////./.(".-.-+../'-.,$+.(.*,-/.&,'+)/+,/*,+.&/+-+,.//+..&.-.++$--..'.--/..',&)+$$(&*''.-)()$%&'#--.*&-,,'*&(&(,+(+)('*+''*&*-*)&#-(*&,($,,-&"....-)/./,&,%)*+'*((*)-/,+/(,/&+-'./"./*'$,.-.,-(-,..&).&%#+(()..*&*$$'.*($..',.()$.&$)+.+(..,,.,.-$'-/-/.(),.&-,+..,,-,,)*.(%('*+(,(,,)(*(&,(.(-.--.(*&-,-,+*%+'$,*-)&,-%*.(+*.-.)#.(.#.-$/++-..-%(..'./-/*/*..&!-.(.#,'%.&.,,,,/+)-.+/+//.)//.,//".-/..,&.&,*-(,..")'/)-',(.'(''./).'.,'/&.."-,$.,#."#/,#./.,&,./'-+&.&%*(*+&'..&/),/'+/%*.--(-/./--)+$%+.)*.-../+),',,./*%%+#,-%*.,#../'-..-,)#&$&&#$+,,.%..-.##,+,,-'$%"#""'(()*&*+,&+++$)))(##&#)*$&+'.....-(.&'''*+&-&-)%-...&).&)+(--"'...)*-.,*+....+%-)&,#$#,&+'+,+,&))&&$#)%,+-...-..($,+.-,.////&(',*(&.--.-),"-./#.%./)/./(/./#-,+-++($-+(,/)+)**/),.)$..).))''&'-.#$+-.'.-$&)--(,-.--'.*-')+.'.&+*(+/..#.,/+/.,,-),.$""%),,'(.)'')'-'.(/+.'#%+'&&&")),#%))+.".-&-*%)(,.$&.+)(','/-..()+/..,(#).,())&-$-//.,...#--...$-+-.-..+.,#'%&.*#/..$--)-'$-.*$'+.)...#.').-**.),/.//)..&&%'-',.#,*////..((./.(.).+&(&#--.#'..'--+&)..-.'#$''+(#&-)-$.(-)-*-.)-".-)-)##+',+*&(+....-./..('+%&*('-.,--%,-&-'($.)'(.+..,.&-#,,.(-#)-.#..$--.,//*'...,+($+&&(*#+-#*(&'&+('((((&%,&,(&$(+(*((*)'*)(,)%*(*'+,+&'&)++*&+"'(('%%&#((*&($-,,-,.)+-.)+--.)+--''+&%&$*,'),,+)&#*-,,,'(%')&*'-&*+,&*-%(#+&,,',-'#&'&#%*'&)-(&%(--($&.+#)(-%&#--&)%.-$&&..()+,-&),'(%&,*#(,-')*-#-&''#&#-,--.,',),*....$(+'*+*#--)('*,,#,.(+)#*..../-+,($)(#.'.$,///*///...-###',(.*(*/..#&,(...'%-*%#,-,-)*+(.#(#*)*(,#.%/..(./&.%.'.).#-//#//+..//#.$.,$.%,*/#--/./.-).-#*)+#%,')&-&,+)..%-+&..&..-//...*+//)-,,.-+.$+)+*$+.',-("'..*//..-.'%)*%-)&+-.---'(-.-////&(./+*.(%&../../).((,.,"-+,-.//,--.//.,%".&#(..+-.'*#'&'.)-%.-+(.(#,')-..-$('"-./).+///#-),.)('/)-.)$&-,-*$,--(%'$%((&%().((%$&(,'%$-(%"*,.*-'#$(#)$%$+.+(&&&%+')/'/./**,-'#),,--*.)'.-.)-/+-#&.+-,-/.,././....**..+,/./'/-,*-,.///'",,.....+/),-*/-/'//#-)+/.'.*$$&.-.///*/'.&+.*/)/-+///.*+-,',-//../-%#$%#*),'*%'",-,-('.#...+'%''--*.*&,.(*..'....&#.-$+.#,%)--.+./.'/-//+"/+.-$%&'%.-',.+'-/-(,+/+#..%--%$)&&.(*+*.*..$(+*,..'+++',.-'))%.-(*-+*&-&%*'&**((-.'.&-..&'-,(*)*&%#&$+...*/+#(*)-)+./+),'.)..-.%+....'..(++*,+.+--**-##-.+$"&(*,+.*+,//////.,(-&,/.//*///%-#--%'.#+--$()(/.//..*.*-&','()..,+.**%%-*,&"*&$'.)$-)/..-*/*'*-&',-..+//+.(-).,.$..+%.,-#.+,*&//,/.'-)(,(.#//,-/,.)-+.&#-+'.")/+',-$.,)*./.+/-$/,...///..("*,*/.-//-..(%-),.+)/,.*.+.,..%*#)&)+*%(*)',-.-"/--)%(#*(./')+//.$+,)&.()'..--.'()'--.#&',+$&...&+-&&#+.././.%%"/,.//.&*#$#-+'.)///,..././/*,'#./,.*+.(../.')*.#*##,+'''--(+'-+&$-,.&(..-.-)%-+'.)/,(-.././.-('/'--*.)-(+,-."/.///-$.')+.,),()(+.$+-+-)''(/(/...*'"$"-../)'/+.(./,'/*,''('++...((%.$-(//.",*/.)(/.*)&-,#+/%,...'-#--'*.-.'&-,/.)...,%,.$/../.-'&+'--%--..$///,-&-+-.+..**(-&+./,.,'()'%--(-///,./////'.-/&/.*/*..#&++)-$'-+-#-,'(-/&/*//////(.+//+....-.".-.'--,&'%(*.&."/ @rCer/1286/25_1766_CCS ATGGGGGTAGTATGGCATCGAGGAGAATGGAGACCAAACCTGTGATAACCTGTCTCAAAACCCTCCTCATCATCTACTCCTTCGTCTTCTGGATCACTGGGGTGATCCTGCTGGCTGTTGGAGTCTGGGGCAAACTTACTCTGGGCACCTATATCTCCCTTATTGCCGAGAACTCCACAAATGCTCCCTATGTACTCATCGGAACTGGCACCACTATTGTTGTCTTTGGCCTGTTTGGATGCTTTGCTACATGTCGTGGTAGCCCATGGATGCTGAAACTGTATGCCATGTTTCTGTCCCTGGTGTTCCTGGCTGAGCTCGTAGCTGGCATTTCAGGGTTTGTGTTTCGTCATGAGATCAAGGACACCTTCCTGAGGACTTACACGGACGCTATGCAGAATTACAATGGCAATGATGAGAGGAGCCGGGCAGTGGACCATGTGCAGCGCAGTCTGAGCTGCTGTGGCGTGCAGAACTACACCAACTGGAGCACCAGCCCCTACTTCCTGGATCATGGCATCCCCCCCAGTTGCTGCATGAACGAAACCGATTGTAATCCCCAGGATCTACACAATCTGACTGTGGCCGCCACTAAAGTTAACCAGAAGGGTTGTTATGATCTGGTAACTAGTTTCATGGAGACTAACATGGGAATCATCGCTGGAGTGGCGTTTGGAATCGCATTCTCCCAGTTAATTGGCATGCTGCTGGCCTGCTGTCTGTCCCGGTTCATCACGGCCAATCAGTATGAGATGGTGTAAAGAGAAGTCTTTCAAGAACGACGGAATAAGAGACCTGTTTTAAAAAGGAACTGCAGCAATCTTTGAAAGACTTCCAAAGAATGTTAGAGCACAGTACATAATACACCTGCCCTGCTCCCTCTATCCCTTACCCCCCACGTGCAACTGACACTCCCACCCAGTCTCTGCTCCACCTTTCAGCCCATGTCACTTGTAGTGTCCATTTTGTGAAGCCTTGTTGTGCCACAGAGTGTAGCCAGGTCCCCTTGCAGCTAGTCCTAGTGAACCTCACCCGAGGCCCTGCATGGGCCAGCCCCTCCATCTGTACTTGGTCCAACTGCAACTCATCATCGGTGACTGGTTATCACACCATCGCTGGCCCCTTTGGGCCCTGCATGTAGTGTGGGAGGCTCCTGTTAGCTCCTCACTGTGGTAAATGCCACACACCTTTAAGTAGATAAGCAGACGATAATTATCTGTTCTTTTGACTTAATCTCATTTGGTTTGATTTTCCCTCTACTAAGGCTTTCCTACCTTCTTCAGGCTGCCTAAGACATGTAAAGAAACACATCGATAATTGTCCATGAGGAGAAAAAAGCATGTGTCATGCATGAAGGAAACTGAGCTTTAGGTGGCCTCCTTGCTTGTTACATACCTGGGTATGTGTAGGCAGTTTAGTGCATCTTTGCCTCTCAGTTGAAACCTGTATAATCCTGTTACAAAGCTGTGTTGTTGCTTCTCGTGAAGGCCATGATATTTTGTTTTTCCCCAATTAATTGCTATTGTGTTACTTTACTACTTCTCTCCGTATTTTTTTTCTTGCATTGACATTATAGACATTGAGGACCTCATCAGAACAATTTAAAAATGAGTGTGAAGGGGGAACAAGTCAAAATATTTTTAAAAAGATCTTCAAAAATAATGCCTCTGTCTAGCATGCCAACAAGAATGCATTGATATTGTGAACATTTGTGATATATGTATTAATAAATAGAGCAATT + EJ5JKKKFHJI.@CBJBKKKJGKFJEHIJKGKJKK?KKKKFKFKJHIFJKJCAK;KBKKIDKHFHEKJIFKHJDKKKJGK=KKHFCKJJGIJKGGCFJKDJHH7ECK9KKKGKB.K4>AABD?IIKJJEJIEHEDIEBKJHHFDFKIDGKFKE5JKAIGHJJ=KJIKJEKDEJJKKJHKFKKKFKHHKICKJJIDHF=JJHGIJ>HIJHJJGIKKJJIKKKKK@BJGKIKGJGEJAKKJGKGKKEJKII@KJE95HEKGKAJKJIKGHDKKKI>@EKKKJGFDKK>EIJJKKEKKJ?KKGJJIIKKIJKF8KKKJBK>HKFJGBIHKDJJJKKKIJGKIKJKKJK?DKKKCKFJBHJHDK6KKDJJ9JBIKHHJIDKJ>JKGHJBKIDEDHEDCBDKFKJCH=IKGK>HDFGKKJFKIGHCJIJCGKJKJKKJKJEIKI?FDKKKKKKKJKJKKKDKKIIKGJKJKKKJKKJJKKJDKKKKAKKIBJKKKKJKBKCKJJ:;=KJKJHHKKKK=KKKJKIGIGJHJKAEKJEDFAEHIJ?KJFII:H@FKJK,JJK>IJKKHKBKHKJJKIHEKAH3IHC4KJGFKJHCHG(G?CFDEHEIIJCIHE9JJEHA9JKFBKHHJJJIJKJJEAKF@IBGJ?GB=AJFCJHJBADKHG5IAH=FJ>;HIIKKGJKJJK?GI?JHJJ=JG==HJJDKKKDFJG@KA:KKKCGIJGJJAIJIFKDGGGDCJIKG=A%?GHJHK9KKKKKGD=KJ?GH?4KJJHKKKJKEIDKKIK;HJGJ@KKIGKKJJJKJIJ6AJAJEJJEKJKJIIJKKEKJKJKKGKK1KJKKKEJKIJJJJK@KJ9>=JJHKJKGKEGIJAKAIJKKKHIJDCKJAKIKJJHCAIKHKKFKKJHKCBJIGKC>>IDEJJKFKKJKKKJJHBKKK@KKHJKIJJKKJJKIKKKJKK?JGGKJH&KKKJKJI?KKFJJDFIJJIBKFKHKGKKKDHFKKFKKJ=FIIKJFJKCKKJH>KJHKJJF>JFIHHKKJEFJJJJIHKKKKJKKGJDGHIHIBKKF6KJJJFJKDKK1KKGKIKDJHJKIHJJKHK@E@GIJKIKKIIKIHKKIIKKEEKEJFKDFIKIEHIKJ6JIK=(GKKF61;FAHGKJKIKGFJE6KBKHEKJI;KKIJKIIBIKJDGIJJJI3KKKKJKKKKKKKKJKIJJKJKKKIFIJKJKKIJKKIKFKKGJ?G;KKJK(KK6IKKKIKJJ@HH>7K3HKKKIKKFKI>H;KKK@E5KKKK%?KKKKKKJ+JG.KHIJJ?HEK;KIJKKJIKKKJIFHIKFKKKKGJKIHHIJKKHHJCKKKKDKJJ7GKJKKKJHJKKIIGAJGKKJKKKIKJKKHJGK @rCer/1288/0_2054_CCS GAGAGCAAGCTGAGCTGAGCTGAGCCGAGCCGAGCTGGGGGCGCAGAGCGCGGAGGCGGCGGCGGCGCGGAGCCCAGGTGGCTCCGCTGCCGGATGGGAGTGTCCCAGTGTGCTGGATGAAGCTGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCAGCAGCAACCGGGCCGCCCCCAGGATGAGCTGCGGGGCAGGGGCAGCAGCAGCAGCCAAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCTGGAGGCCGATGGCCAAGAGGTCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGAGCGGTCCCAGGGTGGACTGGCAGCCGGAGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCATCCCTGCCCTACTCGCCCGTCGGCTCCCTCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCCTGAAGGATGAAATTGGAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAAGAAGCTGATCCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAAACCGCTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTTCATGGCGCCCGAGTCGCTCTCCGAGACTCGCAAGATCTTCTCTGGGAAGGCCTTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCCGGGCCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGG + S-+05506./0.*/1531254654+1)28'8<>>;<(69;669893=9<><&;6139@BB6C<-@>6=<=:;?5;A3:,09?0C>?>=AA+>;6B=?;:9=8>24<9C9>7=C==B=48C:=@<7<==AA:><<3@88?;<:78'9;9A7;<563<(6;99<);99==/?9BA9A<(><78>3>96?65@6AB>>;849;?3@AC>=:D=D8GFBCCFBDFFCDC9GCCFB:EAA@0A4E?C=B563B?@A@F::5=BFCDD3;6DGFFFBFF4?A>@?'9AGD+;2B9$?C@:=EA:@8<;9F:ECC.>=C>G@B:>>BGBGAECE8FAA9AEEFAAB@=DF=EB1D>8FGA5FB@2A?CE;CEC>:GA@C@D?EB(>BCB@AE@@3/:C0EAB76FGAF@,CEB9IG@JBGDHFDKFHIFFGJJ9>8EAEE?4?2J@ICDGAJKKDJ;I>EKDIBJCFIIJKKKKH@IIKIH;/*/79=BB=GIKBFGEKJEKCI?KKGKKCFIGBGEDJE7AF?GK@HF9IFKEKJAJ=HFE0HF@;@HF>EJGGJDFKHFJIAGADDHG@KIJKHJ>@A4KKED@;JJJIJGJDK5JGJ8IGJ5%CBFK+EDB?IG;F;KGJGCJDIAJJKKIHKIIK@F>EDKKF0IIK+JGGD:FIJ?IK:D=0797@F>ICKKJBI-FFIFIFJBKHAK2II&GJ;CA&DC:AKKJ5BDHJEKGDFA@FHKI.HIJKJ?H=>II(HD97;EAA@B8+:5?C@DDCDCE.?F?FKHI6DJEFKCCB@HF3D(AG:IHH?;4C7E8JA7I?JHIBAJJH8KKGKAG>IDGFHH9JE9H.CDB9CI9@7@EB5?=:D:HHCHEHJ:FG4JAGGFCHGIJKGDHJIKGG.G@6?KDDHFGG9CJ8EKIDAGDJD=IF=DIHJK@HEJDAKJ;JDI9BGF8IGDI.KEBHDIHD2DDJAFIKGHBBGKGEJ7AEF5HI@KKKFI7CB9J1EIGDEFEIHF@5FH4HGE?99CHEJ3I=I:GKFCH96DADCHH;KJ=<75JEGH@;@A8AIFACFBBEHFHI3@G@:DHBFHKJIKKCAGHBAAHJHBFDEDGBED+ABDBCDIIIGHEHGA3KIJHC=FGDG7GAG@DGGJHKFIJHFF:ECD7@>BCFHGG=AIHCI0KKKGGJFI?EJ?HIEJKFG?H@>KHJHHF5FGGID@KJFFIKHIF3DB@BGGHH6GHG;JBFIKJIJJCIDE@HGEI9JE>BH?EF%B;GHKH:KHKHAKIIEAIGDJBKGF9HBI=KG>@@E9IKF;CCHKKJIKKKIJIJG3IIGKB=H>K?HIIKFJAJ>B(=EEE@;9&?BCE+AAK>IFKJFHKFK?I=JA;KIGJFKAIKFFI@HD<9C?AF6:@;1FKKJCA>,@?GDFDKHDJGGDHJDC@CJI@FHIA1F;KIHBKKJIHIGFGII/JG/CEFJEBIF@:3D<:.:866=5;:45A6A=BA?59:<>,E:88=@?D7>6BF@>;@@EC8AGB5E@1:BE@HE2FGGHGCAFGFH>FAABEBD=FED?E@EB8DC8B?@>HG5HG @rCer/1289/25_1813_CCS ATGGGGAGCCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGCCGTCTTCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGTGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + -+(+-+)",-++-,-+#&&%(&,)-)(+-----,,-*--,)*(,*--+.,..*-.----.-*--'---,-$,,#'+,,*-)+.-,(+---.--)-+)*,-*--+#)++.---,+--&-),,-+-(+--.*+,.,.-,&*'+-)-$$$)%+,-.-**))*+,)--*+,&-*-*$'(-,)(+,#++*+,-(-+)'--,,,$++,,+-('',()..+-,),--,-,.-),+#%#&,,(,,.+-.-,-*-,,(-++,+---,.(*-,,,,*(++-++(,'*),,---)--,*)+)('$+)+(&'(+---,-()+(*+,-*,%,+,)-++-&&+),--)+,-(,-+*',+),-&++-.-.-)--),,-----+-+'*),-+(#%)---.--,)*+,-----*-+')'$,+,+-%*+*++--,.(-,(%+%,$+,.)-,)+-*+,(+,+*&,,-,*----+-.,'+,)+(-,*-++-...--*--**,---+&)&,,--,+(-(--------,-*--+),-,.,--(,+.,(****,)*.-----()--*--,-,,*.+--,&,,+,+,)-,,),(()*+&-*(+(*'+-,),-++,,,,.-*+)-+-*,--,)-)-,)--)*,)---.-+.*,-.-,&-+))-)----,,+%*&+---+(%,,+,+.---,+---+*-+-),((%,--.,--.-*-+-*$).,---*..,,.,--((,+--,,(,,,.-.--,,#*,*-+-*((+--,(-,*,,-,),,----,'(-,('(.+,),*,"$-),),.+-),)*%'-,*)--+*.(-+,,(,--,)-(+-,),-)-,-((-,',---),)+,-.,,.-))*-+-',&*--,,&+)+--(-,--+*&)(-')-(,(,)(-.,&++*'''*),'$,,--,.-*)(-,-*+..-((*+-.-+,-,-.-)--*-+.-,----,*--.,,--+.-()-)$&+)(,-+(,+-%,,--,-----)((*-.+)-&)(($&,---()%*)),.-,-.,--))--+,',-,-,(0.0011+110'0-1,-/1).)/11110101+($.111.2/10/1)/0-*021(1-0,111.)0.-)+0/.000.-0+.,.2002110211.21,1/001/1-./)/11.///20/1110),102/01/+**.-01(/.0+&)-1111111,*1*1/12+0'11-,10,,1.0,/11/1+1/1102100*1.111-01211-.1-0--*.*+12,11/-1110&00/.21021/2111011,111,.21+.//-0,.'-(0012,%0,+(00/-2222220/*0/00/222-/'1/11/.1/12-,00,0.*+021,11&0/.//0--)/010-/*.-201-1111.,-+&,+,*.0,101,10/%-,)-/22+#/%+1,+0010-0-1-0-011-/211020-011).&+,*$.,--*+,*+..,.1,0/012-./1.01111111*02,/,011121211+01021+1.'/-0*11/0101+/0-/&0-/01//.002110.%*2+1.11102111*010-.*'00-*+00222102.10)+01,02/1-221010*/22.0/.11.21,/$//**555453'1001155-41526544(5555/*-6665.6664%554/55053514&3)/0&/0'10///($.,//00&.+,*-.-/.11110101-112+0,-210/1+/./020'.,100)..-1,.01(01'00-1/0.1+*0-1,,*,*.-/0,00,0-.-/)$++/0+%./0&+./,/-).& @rCer/1290/1732_61_CCS ATGGGGGCAGGTTCTCTTACATCGACCGCCTAAGAGTCGCGCTGTAAGAAGCAACAACCTTCTCCTCCTTGTCTCCGCCATCTGCTCTGCAGTCGCGAAGCAGCAACCATGCGTGAGTGCATCTCCATCCATGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACATGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCCGGGCCGTGTTTGTAGACTTGGAACCCACGGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGTAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTTGATATTGAGCGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCCCTGGCCACATACGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAAAGTTAAAATGTCACAAAGGTGCTGCTTTTACAGGGAAGCTTATTCTGTTTTAAACGTTGAAAAGTTGTGGTCTGCTCAGTTAATTTGTATGTAGCAGTGTATGCTCTTATATACAATTACTGACCTATGCTCTAAAACATGAATGCTTTGTTACAGACCCAAGCTGTCCATTTCTGTGATGGGTTTTGAATAAAGTATTCCCTGTCT + KKKKKKJKKKKK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKFKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKK7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKBKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJJKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKEKKKKKKKKKKKKKKKKKKKJKKKKKKKEKKKKKKKKKKKKIKKKKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKBKKKKKHKFKKKKKKGKJKKKK2KKDKKKJKKKKEKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKGKK7KKKKKKKKKKKKKKKKK @rCer/1292/25_1968_CCS ATGGGGGTGACGCATCCGTGCGCCGGTGGAGGGCCAAGTTTCCGGCTTGAGGAACCGTCGCGTTTCTGGGGAGACGCCTCAGCTGGCACTTACCACCGCATTAGAAAGCAGCCTCAGGACCTGCCACCTCCATCACTGGCGTCACCATGGGGGCTGTCCTGGGTGTCTTCTCCCTCGCCAGCTGGATTCCATGCCTCTGCAGCGGTGCCTCATGTTTGCTGTGTAGTTGCTGTCCTAACAGTAAGAATTCCACGTTGACTCGCCTCATTTATGCTTTCATTCTCCTACTGAGCACTGTTGTATCCTATATCATGCAGAGAAAAGAGATGGAAACGTACCTGAAGAAGATTCCTGGATTTTGTGAAGGGGATTTAAAATCCATGAGGCTGATATAAATGCAGATAAAGATTGTGATGTGCTGGTTGGTTATAAAGCTGTGTATCGGATCAGCTTTGCAATGGCCATCTTTTTCTTTGTCTTTTCTCTGCTCATGTTGAAAGTAAAAACAAGTAAAGATCCCCGAGCAGCAGTACACAATGGGTTTTGGTTCTTCAAAATTGCTGCCCTTATTGGAATCATGGTTGGATCTTTCTACATCCCTGGGGGCTATTTCAGCTCAGTCTGGTTTGTTGCTGGCATGATAGGGGCCGCCCTCTTCATCCTCATTCAGCTGGTGCTGTTGGTAGACTTTGCTCATTCTTGGAATGAATCATGGGTAAATCGAATGGAAGAAGGAAACCCAAGGTTGTGGTATGCCGCTTTACTGTCTTTCACAAGCGCCTTTTATATCCTGTCAATCATCTGTGTCGGGCTGCTCTATACATACTACACCAAACCGGATGGCTGCACAGAAAACAAGTTCTTCATCAGTATTAACCTGATCCTTTGCGTTGTGGCTTCTATTATATCGATCCACCCAAAATTCAGGAACACCAGCCTCGCTCCGGCCTCTTGCAGTCCTCCCTCATCACCCTCTACACTATGTACCTCACCTGGTCAGCCATGTCCAATGAACCTGATCGTTCCTGCAACCCCAGCCTGATGAGCTTTATTACACGCATAACTGCACCAACACTGGCTCCTGGAAATTCAACTGCTGTGGTCCCTACCCCTACTCCACTATCAAAGAGTGGGTCTTTACTGGATTCAGATAATTTTATTGGACTGTTTGTCTTTGTTCTCTGCCTTTTGTATTCTAGCATCCGCACTTCCACTAATAGCCAAGTAGACAAGCTGACCCTGTCAGGGAGTGACAGCGTCATCCTTGGTGATACAACTACCAATGGTGCCAGTGATGAAGAAGATGGACAGCCTCGACGGGCTGTGGACAACGAGAAAGAGGGAGTGCAGTATAGCTACTCCTTATTCCACCTCATGCTCTGCTTGGCTTCCTTGTACATCATGATGACCCTGACCAGCTGGTACAGCCCTGATGCAAAGTTTCAGAGCATGACCAGCAAGTGGCCAGCTGTGTGGGTCAAGATCAGCTCCAGCTGGGTCTGCCTCCTGCTTTACGTCTGGACCCTTGTGGCTCCACTTGTCCTCACCAGTCGGGACTTCAGCTGAACTTCTGAGTGCCAAGGACACCACTGAAACTCACAAAGGTCTCCTTCACCGAAAACTCATGTACCTTTTACGTTTGCTTCAACTAAAATATTAAGCGAATGCTTTGCAAGTTTGACTGTATCCAGGTTTATATCAGAAGGTGAGATTGAATAATGCTTGATGCAGAATCTAAACTTCTCATTTATCTGTATATTTTGTTTACTTTTAAGGATATAGCACAAAGGGAACATTTTTTGTTTAAAGTGAACTACAGCTGTGCTGTGAAGAGAGTTCTTTATAAAGCCTGTAGGTTCTTTCAACTTTGGTTTAAAATGTAAGATAGGAAAATGTTGGATATTTGAGGCCATGCTTAATATATTTATATTGCAGTATCCTTT + G>>JKGJGEEGC?JGJKJJGHK:EDGGCKJ@KKBICGI?JKHJ9IJFKIIFJHK>HGI8IKK>IJJF'HI?8>IJKFEFJ=IJ@;DC?H2HFIIJGGEEB=I;H>KKDHIJDI9EC=HHGIBEDKJJKEKKEKHCI;BKDCFEHFJ?D=IHKKHFI>EI=?BKCIDJDKG@9JJJJEAJJJDJEKABI@HCAEEHAIGIIF7A;C?=*@BD8=E*IJHJJJFGEBE6GJCGG?8GI(CKIIKHKDJIIIIKGHJDJI;IIJGBKJJAGK2IKIEDIFBIHJIJDEIIJJKGKBKKFHIDKGFEFGJJBJHCGHI)GFCDBFH?BJ8KKIGF@JJJJIKGDIIBJKIFG;JD6JKFEB?7E$IH<64IH+CEH@0GDHJJJJ?9I6FH?&%2FIIIJ@HJ?EI4KHKKI;H=KJCI=GFCJIKB5D7AJJKIBKCDCJAIKIJGJ>DGAJI=B1EIEKKKJJJGHKIFGEDGFF7IFHGK.KIHDI:HI7I=/KJG@KKJIH@GEFIFIH>H9IKIJJBKFKHKKID6JIEIGJJCADIH8KKKJGKK:KHJJIGJKJJHFEEKDKKJ?JEHC@JHHI?9HH:KKJAKJJKJJD?KFCGAJKJJ;FGKDC8GIGHKCDJKKKGGGCK@GIJG5IIIJFBH*G?HFHAJEJDK=IK94IKJKI3IH9FCGAFIFJ6JJEKK?KCK?JIF@I1EJEAHFEJHKGJFK=HHIIGJHFHI>IH<@H=HG@:4FF>/=GCFDJIKG9BHIHI@7DHC2JJHEAEB;JH>KJJEGDKKIBK;KGKFJJKGKFKGFJIGKJIIKKBJF:DJG2JI=JHAKHKBGHIIIBEJEIHKKKIHKCJJHHCBJIIKGJI4KKIKKJKKFKJKDCF>HBJIEHC7JJ?IKIJIGJ<9DJJ@>KGIGKKI9JJ@F7IH7GIFDJJHEEKKIJFCJBEKJHJIIFJ:IJB7?JDIIHD>&EEFAJDKKJ?KG@JIHAJDKFJGHFIJ4FCKFHJCIIJGH8I?GDIHEDB>IC2HE-FCDIIKJKJHDKIHGJJBKKGIIH3B@DAKHEJI>FJGI4HKFCKIJHJEIKKKKHGID?FBHGEIEHF=KBHHJGJADDKIH7IKCAICKH=IGIJKGJDB@IFJJFJGJI2GH>C=DF?EKA8JI?IG3AGDAIKKJJKJKFKHKGIHFIJJGJJAHDDJHKJIJBK=1IKHH@KJIJ3IKGIGKHFEHGJIJCKK9FKJJJJ4KKKJFBDKK5HGHGDFJJ=>GHIBCF@IKFIJF@G?DABJ.KIAEEBC4IJIGKKKHGGKFKKAKIGGKJEFKHI6KD-IJHHF:4@@:4>:D.GCHDBHJGDDBG0IJ9FAH;J?JHDFK>JHHFH?IG@EFDJJDIIJHFHKEGK @rCer/1293/411_55_CCS GGCTAGGCATCGTGGAACCAGCTCCAGCCCTGAAGAAATGGTAGACATGCAGGTTGTGCGGAGGAGGCTGAGTGGAAAATGGTGTGAGCCTCACCGCCATGGACTGAACGAGGGAAAGCGGCAGCAGAGGAGGCCAGAGCTTGCCCCCTCCCTGTCTCTTCACTGGACCCTTCACATGTGTTTCTCTTGCCCCTTGGGCCGTCTTCCTTCTCCTGAAATCCAGAGACTTTCTTGCTTATCCTTCTCCCTTTCACTTCTGTTCTCTGCTGCAGAAAGTAGCCTTGCGTATCCCTGATGAGCAGCTCAGCTACTTTGTAAACTTCAGATTTGGAGAGAAACATGGAAGTCAGTGAATC + 3'1-)/$+3)54.2--*8646163'4261+$1>313.,37.-%437<373/82-64%/80/7-,33012+3135-436)4$)722,87>862%34:90:.9523.5129:3640*($*00'7597)649(6529/52%2.0&53+,/$)4>-.73A>=A2<5604+353,:695;867/662%7690(<<5.$6#7=2>9=46>>;?A=>>9BA;AAA:963.2+)27635498@>:>:(07+-8>>8:56-18:64.961=16.<9>@07717.08>9857489800+9@=>:C:79;5199<144;8-A@9?9:+@@53;@12&-:0C=74>@4C?;:/8&><&=6830A+85?20?9:898&;<8873,:(/>2<80>>6=>51<-A5)'>8244#9-:=;:*;6><9<)5'8:=60@905232=5&81,A<6A87&=8'&$=59>?9&==.+=+.0;)>==;7=A4;2:1C=:<)7:1758-.1%$9:=<&>?*B,%/>@:,:)8:'@;.*&+*-1:32%<>;9.3=606+&2./><356'(465'83/-<;06+8<;/2/2<8->:8@:<>9C;#194/1%=@63;1'**>>,>9;(:0;.3?5:91A734:0+011%07<*;<2=2%39-0;-*>;<%=2:,/;=57%1&:7*7575;5891>0@:;148*1@8+6361/-*799083<':;7*88'<33$>2'79:7-*?=(?;:+><8>0A0%27=C7+=7-;7;+-6+1=>;9#;9+@=;@9:3<71:#:2=887;(42+B@1>A8)BA5:8,5<<9,A8>(<5>7>91(;92A:*85><456-@:73:(5:81?:/4,?8;1%=8($94(:<;)B'A:9%<97(=:/?C>/A@76%??98='><89404.*6(193A8:1<<@9B385;4''><9@/<1&<2.A4<7&<=<5<2(423/7@:A1C4*@:46&>+=68C?9@7>0-;89-.;:8(*';759>, @rCer/1298/0_627_CCS CCACATCAGTTTATTTCTGTTGTCTCTCTGTTGTGTCCACCCAACATTTCCCAGGGTGCTGCTGCCACCCGCCCCAGCCAGCCACCTGCTCCCGACAGCCAGCAGCTGTGTATTTGACAAAGTCATTGGTATATTTTTACTTACTGGATTCTCCTTGCACTTTACCTGTTCTTTTCCAGAGCTGACAGCACGGGCTCGGGGCAGTGTGCCTGGCTTGGCTTCCCTTCCCCATGGCTGGGGGCTGGGGCTGGACTCACCCATTCTAATTTATTTTGTCTTTTGGCTTCTCAGTAACTGAGGGGAAGGCTGATGTCAGGAGAGGGAGAGGGGGCTGAGGAGGTAGTGCCGTAGGCCCAGGGGGTCAGGGAGAGGGAGGGGGGCATGTGAGGGATGGAAATGACCTCCTGGCACCAGGCTCAACCCACCCAAGGCCCCCTGCCCCAGCACCGAAGCCCACTGCTGCCCTGAGGCCCCCAGCCACTCCCTCCAGCAGCCTGGTTCACCACACAGACTCTGCCTGGACCCCATTGTCTGTCTGCTTCCCACCCACCCTGCCCACCCCCTGCCCCTCAGGCACCAGCCTGCATATGTGTTCACTTTTATTTAAATAAACTTGTGCGGTAAAAG + S''#$'"#$#*&"&(+&$&%&)%$&*(+,-00+.'*$(+,-&$-,-(.($+*)&))((024.41.2*,0(3',10-3.320140/.0+/1(3/0',8-29654.5/0.3512309025-6/)0*.1-.--+*),/*/7/1-,4:668/4765.1.74262+7648755491322827380202:74353+4*1104*&/+'-'-*0,4071576(5.73183496;10736-+0..(0-+/34/*.(0/613+848+9844662)2$-2-*.554572675-374038493,-42-0.)653/**(0$/100.35(.113-0&-.4-15,42357024+/.-,2--0-'4155;5,'$43/'/5,4*/1//621,405416/-03+2247-3794115+'.42.-1'/.3%1(-0/46&-13:3)0)%0(2*8974.4/786031153664.'20235-31/.7*/8.2.11(344/,1.0/1+/,3395/12/8834.62534++/''151)))*,130-+(%+&121113.14094326-:4.1.04:89685752(55+4:435:5)34+**3&1295/433842354655021/9356357*41-69;311443/69:-67:2 @rCer/1299/30_3354_CCS GGGAGGTGAGGAGACGTCGCCGGGTGAGGAAGCGGGGGGCTAGCGGCCTGGCGCAGCGGCGACCGGCCGGGGCGTCAGGATCCCTGGCCCCCGGAGAGCGAAGGGCGGGCGGGTCCCGGAGCTTCACTAACCCGGTGCGGAGCACTTGGCGACGTCTCCCTGCCCATCTCATGTCTCTCGGCTCATCGCTGCTCTGGGCACCGGCTGCCTCTTGGCTGGCGCTGCTGTCACACGGTGGACTGTTCTGGCCTTACTGAGCTGCCGTTTGGGGACATCAAGATTCAAGCAAGAAGAATTGTATAAAATGAAAAAAACATTGATGTGTGCTTCAAATGTGGCATGAAAAAAAAAAGGACCTCTGATCAAAATTGACTTGAGTTCAGGATTTCATGCTGGAAGGAATGTTAGATGTAACTTCTAAATTTCTAGTTCCAGTAAACATCTCTTCTTGGAAAATTTCCAAAAGAGAGTCCTGCTCTGTTGCCCAGGCTGGAGTACATTGGTGTGATCATGGTTCACTGCAGCCTCGACCTCCCAGGCTCAAACAATTCTCCTACCTCAGCCTCCTGAGTAACTGAGACTATAGAAATATGTGCTTCTTGAATCAACTGCAGTCTCTCCTCTACATAAGAGCTCTTAAGGGTACTAGCAGGATAGAAGCAAATGAACCTGAAAGCTCATCTGCAGCTCAGGAAAAACAAAGACATGGAATTTTAAAGAGTGAAGGTAGCATGGTGTTGGCCATGGGTGAACAAGACACAGCCAGACAATGTGGACCAATTTCTTCAAACTACGGCTTTTTTGCTGTCTGCTTGCAGTGTTGATGGTGGTGGTGCTGGTCATCAATGTTACTCAGGTAGAGTACTTGGACCATGAGACTGTTTCAGCCACATTCATCGACAGCAGTGGACAGTTTATTTCCTCCAGGTGACAGGAATTAGCCGAAATCCTTACTGCGGGCTATGATCAGCAGATCCTGTCCAGCCAGGAGCGCATGGAGGAGGACTCCTTGCTGGCTGCCTTGCACCGACAGGTTCCTGATGTGGCCCCAGTTCCCTTTGTGAAAAGCACTGACCCTTCTTCCAGCTACTTTGTCATCTTGAACTCTGCTGCCTTCTTTCAGGTGGGAAGCCAGCTGGAGGTGCTGGTTCACGTACAGGATTTTCAAAGAAAGCCCAAGAAGTATGGTGGAGACTACCTGCAGGCCAGAATTCACTCCCCCAAGCTGCAGGCTGGGGCTGTGGCAGGGTGGTGGACTACCAGAATGGGTTTTACAAGGTTTTCTTTACTTTGTTATGGCCGGGCAAAGTTAAAGTGTCCATATTTTCTGGTCCACCCCAGTGAAGGGATCAGAGTTCTTCAGCGCTTACAGGAAGATAAACCAGACAGGGTCTATTTTAAGAGTCTCTTCCGTTCGGGAAGAATTTCTGAAACTTACTGAGTGCAACGTGTGTCTTCCTGGGAATCTGCCCCTGTGTAACTTTACAGACCTCTACACTGGGGAGCCCTGGTTCTGCTTCAAACCAAAGAAGCTCCCTTGCAGCAGCAGAATTACCCATTTCAAAGGTGGATACCTGAAGGGTCTCTTAACTGCTGCAGAGAGTGCTTTCTTCCAGAGTGGTGTCAATATCAAAATGCCAATCAACTCCAGTGGACCTGATTGGGTAACTGTGATTCCCAGAAGAATAAAAGAGACTAACAATCTAGAACTATCTCAAGGCTTAGCAACTTTTCCTTCTGGGTATTATTATAAAGACCAGTGGAGGCCAGAAAGTTTAAGATGCGTCAGTTTAATGACCCTGACAACATTACAGAGTGCTTACAAAGAAAAGTGGTGCATTTATTTGGTGACTCAACCATCAGGCAATGGTTTGAATACCTTACAACGTTTGTTCCAGATTTAGTGGAGTTTAACTTGGGTAGTCCCAAGAATGTGGGTCCCTTCCTTGCAGTGGACCAGAAGCACAACATCCTGCTCAAATACCGCTGCCATGGTCCACCCATCCGCTTCACAACCGTCTTTAGCAGTGAGCTCCATTATGTGGCGAATGAGCTGAATGGCATTGTGGGAGGGAAGAACACAGTGGTTGCCATAGCTGTATGGTCTCACTTCAGCACCTTCCCTTTGGAAGTGTACATCCGGCGGCTCAGGAACATCCGTCGAGCAGTGGTTCGGCTCCTCGATCGAAGCCCAAAGACCGTGGTGGTCATCCGGACGGCCAAATGCCCAGGAGCTGGGACCTGAGGTGAGCCTTTTCAACAGCGACTGGTACAACTTTCAGCTGGACACCATCCTTCGGAGGATGTTCTCAGGGGTTGGAGTATATCTCGTCGATGCCTGGGAGATGACCCTGGCCCATTATCTACCGCACAAGCTGCATCCAGATGAAGTTATTGTGAAGAACCAACTGGACATGTTCTTGTCCTTTGTGTGCCCCTTGGAGACCTAGCCTGGGAGACCTAGCCTGTCTTGGAAGGGACTGGAGGAATCATATTCAATGACCTTCTCAATTGACCTGAGTTACAGAAAGTGGCCCCAGTGAGAGCTGGACTGCCATTAATAGGCATAAAATTCAAAAAGATCTGGACTTTATATGATGACTTACAAGGAGCTTAGAAAATGCAGGTTACATTTATATCTACCTATAGGATTTATCTAATCTTGACTTAGCCATGGTAGAACTCTTAACAGCATCTACACACTGTATTGCTCTTATAACCAAAGATGCTAATGAGTGTATTTGAATTAGCTTCTCCTGGGAGGGTTGATTACTTTGCTAAAGAGTATGAAAAAATATTCTGATGGAAGGGACAAGTTTGGCTGGTAGTAGAGTGTTTGTAGCTTATCTGGTAAAGGAATTGGAGTGCATCTGCATGCATAGCACAAGTAGTCCATCTTCTGGCGGTTAACTAGAGAAAGCTTACAGTCAGAGGCTCTTGTGAATGCACTGAAGACTGCTGTGTCTCAGGAGTTTCTCTTGATGATCTACCTTTTCTGAATTACTTGAAAAAGGCCAGTGTGCTTGGTTCGAGTTTTTTAGTGAGAATATTTACAATTTCCTGCTTTTATCTAGAAAAGAGCAAAAGGGAACTATGAAAGCAGTATATTATAAAATCTGTGCTTTGGAATCGACATTTGCATTTGTGATTTTTATTTGATTCAGCTAAATTTTATGTGTTGAATACTTACTCTAAGAATAACTACTTTGGAACTGGAAGGGGGAAATCTGTAAATGGAAATTTATTTTTATGATCTGAAATTTGAGGTTAAGAAATTGACTTTTGTGTAAAGAATGCTATTGTAATTATATAAGCTGTGGAAGT + ,..-)-(++,-',-,(&+*,.,.,-+),-(,%,(-*(++(++),-.+.--.------,.+'()-,-*.'-++*(-,--.---..+#+)--).,-',+---)+&--+*..-),-*)--))-*,%+')*,')(-.-,*+,-.,*)*',.)-,)(+--,*'--,-)-,),()&'--++*,*,',,-),-,,&,--+,+#)'%'&,(,+---.,,(+&,--,.---+*,))&%*-,,--)-.,-*+(+*-,.+.)''%$*+*,(''%(,..+..-+-,'+#(++'-)$%',-.+),,--),++-'(',,+,$,,,,*+*)(,,-'*(,--+)-*(,+(+++,-+$)'----*---,-,--,----)-+,...),+,*$,+-+%*+-+,,&)-,-&+-),-(+&*+---,.-**-----'-,++%+++..-)))-.)---,(,,),*-+-,.,$))-(*,-,.-'+(,-+,---++&+&**-----+*,.,+(,,,)()((+*---),+-+),-,),,.,.--+--+'+(&%&&)+))(,+,-.,),,..+(,+-,,)*%)+.-++,,.),.-----,.---,$*-)-*$*,-.,---'))'()(,&,.,,*-*+(&*----+,'+&)&'+--(,,,,*$'&***)++*---+))+,)+('*+-(,(,11/-2020/'0///+,+--+-0*,-.1/&&#///.,)0.,/*/,+-+//222%-++'/.1.0,0*&*0/1).(%)1.0.2/1,0,*.)/+//11/1-/1021+*-/0/---00-1--+/1/*00022101/*1/-22222/1-00111*-/001010*0+-/00*(-&-1,.)$-*'0*0.-010,10.#,,).*001100012+1//2,,0.,0-1/121/,/02011(1..1/&/11111,1121010.22.'01/.,$/-/2*00-++.-.-111121,/0/-/+0+.+.+%./0*'&.*.111./1*+00111.21..210001110,-001,0-02/,/./02111121.1-/*1,-112+*/')-*0.1(//110(+&'//1/',(.0%//0/-'000.0111-/*11/,.,++0+++-10(+0-1/-00%/012100111-0,2020*,.+,12*)-10-.01-00-*,.-0,0,+,+.21101',-1101,111/+10,0221*10,/+&./'./)/0-0-(/,+1-010*-1212/*+/-1/&,,+010.,210/,/11011+-0-+)(+$/*,*-*(,1-.-01+1.111121102*/01,-.202*10.+-20(01220&/,0)/+/,0001120'.%,.1/00.2111&//.011211/1-021-/,/'0022101-11.-00-/0,/1.-*/010-/-2+*(-,00/1(+01-021,00$00-+0,0/10.1*/-01-2.)-.-20'--221*/$/-+#(*0101/*0/.000--0-$'.0.0/&-./21..1+111/.-,/-0-)-.-*011/,-*/,+/1,(///.+.22-02-00.1.+//-11.-(110-1011(00121111.00011,1020'00.$/./)/000+0./(1/.+,.21021111.-+1111,+.11/111--./),/+*1121000+,0*/-++-*+0,)110/0&/,/.0,00112111./-.111-&/*-0/+1011-/,020001/&,.-01)10),00.,.(//+21/111111110/*/-202,)0+01,0/+/1.&0+0.1-01.)'0)+/-1*-1---0'/,,/*,*&//1-210-/0.211)0.1-+*0,11/2.11122-/-0+101.21,/1/0,00*1/1*0.&./10/,---(.*,201.20-//.-0.11,00110.020%0/,,#./.121,/2.1.*.*,,')*/0/-/-1/'-10005454131.3225+41351('0-)1./624/3422+4005.1.43463312/1015.04002.1.'+/4140*/(3+%',3-1-2/3)$-01.2+/06420661/440100/025.'03350-.251133/23-431511043(005.013.+45463$*501,665466*555011/002--+434203./30411/442.35.1461.52.40+4+-3%22064401)/335213,.3+53-1204,.34-/4/-36226664245640622,5*)+444./1--,/1160/311'/4)/24041-51532)015&-+/5,553,5/24236.)-1/55.1/44/*004265*31.061.36436420044466350.46124054414*55555162,0&/.132)2//162445/502-2424/365+/+51-41,/625056664336002233015,1*-542-512202,3666165+34455.01*,-2424*5252543/5564+1...///246655114/563*4420/0063/545146634-040,302.//24356+6066235*/2063635646664.4222/146665.3336652663436.3.03464225+44421,3104511%,/46655406554123.2/+441%11(556406354450.,223512(03152*224++(4323.24506604$,1**&-)/1-11-32,310',)244162#42022*/001-,515/64116,3*+/-,*/445/5441316312-/410542145465341.3565204'1332.644*3/0521235*53.3256/00+3+/02.%.,+*11361)*400365105*330200.+2(3354.+.-0+(),&)2+0311)3-52-251*13.6//*0144445&032(0.5-.020'254,1434-5,1.45134/243643-1.0///..04*3-0,)+266433/10154.50255265335*43,3133414.-/+-05-0514450&1150334403045/65.3-.351.).1/4(4/-*1.50/.35+14/461656404,0'41*#*'$-./,/4564.01-11'4/2-345/2'4354/),131300*2.4342,5-5531235-665455513-/2245/1/255456*2544'2)115-..,*0,%,.-(.-+1443(,3+12(1*.-2.).4/1655/'31$+31$3201/0/41.+510/51/62(224.1124.2./535232301,%$'/+42.../)/%-.%'&2(1.1/2*153/*32./221+2../2$1.%--0+.364*(,+'.-1,62(.1,-'-$,-0.%.+%**/,+-0/*.0-*110/0-.,++,+/-%-/0.-)&)+-1+.*-.'/$% @rCer/1302/25_3043_CCS ATGGGGAGAGCCAGGGTAGATGGGAGGAGACGCATCACCTCCGCTGCTCGCCGCCCTACGTCTCTTCGGGGGAGATGATGGTGGGGGGCCTGGCTCTGGCCGCCGCTGGGTCTGGCACCCGCCTCTCCCTGGCTCGAATGCCCCTCCACTCCCGACCCGTGGACTCTCCCTGGCCGGAGCACTCAATGCTGGCTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCCGACGTCTACCAGGCTGAGCTGCGAGAGCTGCGACTGCGGCTCGAATCAACTCACCGCCAACAGTGCCCGGCTGGAGGTCGAGAGGGACAATCTGGCACAGGACCTGGGCACCGTGAGGCAGAAAGCTCCAGGATGAAAACAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGGAAGCAGATGAAGCCACCCTGGCCCGTCTGGATCTGGAGAGGAAGAATGAGTCACTGGAGGAGGAGATCCGGTTCTTGAGGAAGATCCACGAGGAGGAGGTTCGGAACTCCAGGAGCAGCTGGCCCGACAGCAGGTCCATGTGGAGCTGGACGTGGCCAAGCCAGACCTCACCGCAGCCCTGAAAGAGATCCGCACGCAGTATGAGGCAATGGCGTCCAGCAAACATGCATGAAGCTGAGGAGTGGTACCGTTCCAAGTTTGCAGACCTGACAGACGCTGCTGCCCGCAACGCGGAGCTGCTCCGCCAGGCCAAGCACGAGGCCAACGACTACCGCGCCAGTTGCAGTCCTTGACCTGCGACTCTGGAGTCTCTGCGAGGCACGAACGAGTCCCTGGAGAGGCAGATGCGCGAGCAGGAGGAGCGCCACGCGCGGGAGGCGGCCAGTTACCAAGAGGCGTTGGCGCGGCTGGAGGAAGAGGGGCAGAGCCTCAAGGACGAGATGGCCCGCCACTTGCAGGAGTACCAGGAGCTGCTCAACGTCAAGCTGGCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAACCGGATCACCATTCCTGTGCAGACCTTCTCCAAACCTGCAGATCCGAGAAACCAGCCTGGACACCAAGTCTGTGTCAGAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGATGGAGAGGTCATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGAGGCAGGACCCACCTGGTGGCCTCTGCCCCATCTCATGAGGAGCCCGAGCAGAAGCAGGATAGTTGCTCCGCCTCTGCTGGTGCATTTCCCCACACCTGAGCTCCCCCCGCCACCCCAGCTGCCTCCCCTCCCTCCTCTATCCCTAGGCCAGCTTGCTGCCCTAGGCTCCCGTCAGTATTAGGCCTGCCAGACGGCACCCACCCAGCACCCAGAAACTCCAACTAACAAGAAACTCACCCCCAAGGGGCAGTCTGGAGGGGCATAGCCAGCAGCTTGGGTTAGAATGAGGAGGAAGGAGAGAGGGGAGGAGGGTGGGGGGGGACCTACTACATCGCCCTCCACATCTGATACCTGTTGTTATGGAAACTGTTGCCAGAGCTGGAGGTTCTCTCAGGGTATCTGGGAACTGTGCCTTTGAGTTTCCTCAGGCTGCTGGAGGAAAACTGAGACTCAGACAGGAAAGGGAAGGCCCCACAGACAAGGTATCTTTGCCAGAGGCTTGTTTTGTTTTTTGGTTTTTATGAGGCGAGGTCTCCTATGCTGCCCAGGCTGACCTTGAACTCCTGGGCTCAAGCAGTCTTCCCACCTCAGCCTCCTGTGTAGCTGGATTACAGGCTCGAGCCACCATGCCCAGCTCAGAGGGTTACTCTTCTAGACTGACCCTGAATCAGTCTAAGATGGGTGGGGATGTCCTGCCACATGGGCAGTCACCTGCCCAGATCCCAGAGGGACCTCCTGAGTGATGACTCAAGTGTCTCAGTCCACCTGAGCTGCCATCCAGGGACCCTGTCTGTGGCGTGCTGTGGGCAGGTGGGAGCTTGATTCTCAGCACTTGGGGGATCTGTCGTGTACGTGGAGAGGGGATGGGGTGCTGGGAGGGATACAGGGGGCTGCCTGGTCCCCAGTGGTGGGTACAGAGAGGTCAAGCCCAGGAGGACTGCCCCGTGCAGACTGGAAGGGATGCTGGTAGAGATGGTGGAGGAGGCAATTGGGATGGCGCTAGGCATCCAAGTAGGGGTTGTGGGTGACCAGTTGCACTTGGCCTCTGGGTTGTGGGAATTAAGGAAGTGACTTATCCTCTTGAAGATGCTGAAAAAGGAGAGAAAGGGATGTATCCATGGGGGCAGGGCATGACTTTGTTCCAGTTCTAAAGGCCTCTTCCTTGCTGTGTCATCCAGGCCATCCCAGCCTCTGAGCCCCTGGGACTGCTGCTTCTTGACCCCAGTAAGCCACTGCCACACCGTCTGACCTCTCCACCCCATAGTGAGCGGCTGCTTTTCCCTAAGCCAAGGGCCTCTTGCGGTCCCTTCTTACTCACACACAAAATGTACCCAGTATTTTAGGTAGTGCCATATTTTACAATTGTAAAACAAGCACGAGCAAAATGAAGACACTGGCTCATATTCCTGCAGCCTGAGGCCGGGTGCTCAGGGCTGACATGTCCACCCCAGTGCACCCACTCTGCTTTTTAACTGGGCAGACTGGTAAGCAGACTGGTGGGATCTGTGCCAGAAATGGGACTGGGAGGGCCCACTTCAGGGTTCTCCTCTCCCCTCTAAGGCTGAAGAAGGGTCCTTCCCCCTCCCCAAGACTTGGTGTCCTTTCCCTCCACTCCTTCCTGCCACCTGCTGCTGCTGCTGCTGCTAATCTTCAGGGCACTGCTGCTGCCTTTAGTCGCTGAGGAAAAATAAAGACACATGCTGCGCCCC 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@rCer/1304/24_2527_CCS ATGGGAAAGCTGAGATCCTACAGGAGTCCAGGGCTAGAGAGAAAACTCTGCGAGGAAAGGCAAGGAGCAAGCCGCGAATTTAAGGGACGCTGTGAAGCAATCATGAATGCAATGAGAGAGGGCTCTGCTGTGTGCTGCTGTTGTGTGGAGCAGTCTTTGCTTCGCCCAGCCAGGAAATCCACGCCCGATTTAGAAGAGGAGCCAGATCTTACCAAGTGATCTGCAGAGATGAGAAAACGCAGATGATATACCAGCAACATCAGTCATGGCTGCGCCCCGTGCTCAGAAGCAACCGGGTGGAATACTGCTGGTGCAACAGTGGCAGGGCACAGTGCCACTCAGTGCCTGTCAAAAGTTGCAGCGAGCCAAGGTGTTTCAATGGCGGCACCTGCCAGCAGGCCCTGTATTCTCAGATTTCGTGTGCCAGTGCCTGAAGGATTTGCTGGAAGCACTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACCAGGGCATCAGCTACAGAGGCACATGGAGCACAGCAGAGAGCGGCGCCGAGTGCACCAACTGGAACAGCAGCGCGCTGGCCCAGAAGCCCTACAGCGGGCGCAGGCCTGACGCCATCAGGCTGGGCTTGGGGAACCACAACTACTGCAGAAACCCAGACGAGACTCAAAGCCCTGGTGCTACGTCTTTAAGGCGGGAAGTACAGTTCAGAGTTCTGCAGCACCCCGCCTGCTCTGAGGGAAACAGTGACTGCTACCTTGGGAATGGTTAGCCTACCGTGGCACCCACAGCCTTACCGCATCGGGTGCCTCCTGCCTCCCGTGGAATTCCATGATGCTGATAGGCAAGGTTTACACAGCACAGAACCCCAATGCCCAGGCACTGGGCCTGGGCAAACATAATTACTGCCGGAATCCTGATGGGGACGCCAAGCCCTGGTGCCACGTGCTGAAGAACCGCAGGCTGACATGGAGTACTGTGATGTGCCCTCCTGCTCACCTGCGGCCTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAAAAAGGAGGGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCATCTTTGCCAAGCACAGGAGGTTGCCGGAGAGCGGTTCCTGTGCGGGGGCATACTCATCAGCTCCTGCTGGATTCTCTCCGCCGCCCACTGCTTCCAGGAGAGGTTTCCACCCACCACCTGACGGTGATCTTGGGCAGAACATACCGGTGGTCCCTGGTGAGGAAGAGCAGAAGTTTGAAGTAGAAAAAATACATTGTCCATAAGGAATTCGATGATGACACTTACGACAATGACATTGCGCTACTGCAGCTGAAATCAGATTCGTCCCACTGTGCACAGGAGAGCAGCGTGGTCCGCACTGTGTGCCTCCCCGGCGGACCTGCAGCTGCCGGACTGGACTGAGTGTGAGCTCTCCGCTACGGCAAGCATGAGGCCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAGGCTCATGTCAGACTGTACCCATCCAGCCGCTGCACATCACAACACTTACTTAACAGAACGGTCACCGACAACATGCTGTGTGCTGGAGACACTCGGAGCGGCGGGCCCCAGGCGAACCTGCACGACGCCTGCCAGGGTGATTCGGAGCCCCCTGGTGTGTCTGAATGGTGGCCGCATGACTTTGGTGGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAGGATGTCCCGGGTGGTGTACACCAAGGTCACCAACTACCTAGACTGGATTCAAGACACATGCAACCGTGACCAGGAACAACGACTCCTCAAAAGCTAATGAGACCTGCTCTTCCTCTTTAGAAGACACTGCAAAGCAGAGTGCTTCTCTATACAGACATCTCCAGACCACCACACCGCAGGAGCGGGAGGACCCTATAGGAGAGGGAAGAGTGCATTTTCCCAGATACTTCCATTTTGGAAGTTTTCAGGAGTTGTCGATTGCAGGATGCTCTGTCAGATGGAGACATGAATGCATCCTAGCCTCTCCAGGATGCCTCCTCCCAGGGCAGAAAGTGGCCATGCACCCTGTTTTCAGCTAAAGCTCAACCTCCTGACCTGTCACCGTGAGCAGCTTTGGAAACAGGACCACAAAGATAAAAGTATGTCCAATAGTAAAACATAACAAGATCTTTCAGGAAGACGGATTGCATTAGAAACAGACAGTATATTTATAGTCACAAGAGCCCAGCAGGGCCTCAACGTTGGGCAGGCTGGCCAGCCCGTCATGTTCCTCAAAAGCACCCTTGACATCAAGTCTCCTTCCCTTTACCCACTCCCGGCTCTCGAAGGTATTCCTTTTGTGTACAGTGTAAAGTGTAAATCCTTTTTCTTTATAAACTTTAGAGTAGCATGAAAGAATTGTATCATTTGAACAACTAGGCTTAGCGTATTATAGCAATCCATGTTAGTTTTTACTGTTGCCACAACCCTGTTTTATACTTACTTAATAAATTCAGATATATTTTTTCACGGTTTT 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@rCer/1305/24_1840_CCS ATGGGGAGTCTGGGCGCTCCCAGCCGGTCCTGGTGCTGCGGTTGCGAGGAGACGCTGCAGCCTAGCTGGCCCTGGCAGATTCTTCTGGAACCCTAACGCCTTCGAGACGGATTCCGACCTGCCGGCTGGAATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCCAACAGGACCACCAGTGGGAACCCCCCGGCCGGGCCTCCCCCTCACAAGGAGCAGCCCCCAAGAGGAGTCCCAGCTCACCTGGACAGGTTTTGCTCACGGAGAAGGCTTTGAGGATGGAGAGTTTTGGAAGGATGAACCCAGTGATGAGGCCCAATGGAGCTGGGACTGAAGGAACCTGAGGAGGGGACATTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCATTGCCCCAAGAGGAGGAGAAGCTACCCCACGGAATACCAACCAGGGATAAAGTGTTTCGCCGTGCGATCCCTAGGCTGGGTAGAGATGACCGAGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTGCATCCGTCAGCTCTCTTACCACAAAAACAACCTGCATGACCCATGTCTGGGGGCTGGGGGAAGGAAAGGATCTGCTACTAACAGCTGGAGGACGAGACGCTAAAGCTAGTGGAGCACAGAGCCAGGCACTGCTGCACGCCCAACCCATCATCAAGCATCCGTGTGTGGGGCGTTGGCGGGACAGTGGAAGAGAGAGGGACTTTGCCTACGTAGCTCGTATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCCGCCAAGAACATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCGAACGGCGTAAATGCCCGCTGCTTGGTGAATGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCTTTCCAAGTGGAATTCCAGCGCCTAAGAATGAGTTGGTCCAGAAGTTCCAGTCTATTACCTGGGGAATGTACACTGTTGCTAAACCTGTTGGGTAATGTGATTAATGGGGCCTCGAGTCAGTCCTGTCTCCAGCAGCGTGAGCAGTGGACCCAAGTCATGTCAGTGTGGCTCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGTGCGTTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCACACATTTGCATTCATCATGGCTGCCGCCAGCCTCCTTCTGCTGCACATGTTTTGGTGCGAGCCAATGCTGCTAGACCTCTCAGAGGCTGTGCAGGCTGCGTGCAATGTCCGCTACAGAAGTGTCTGATCACGTTCCCAGCTCCATTCCTGCTCCACAACCTGCTGAGTCGTGGCACGGCGTGTAGGTGGACTGTCCCAGGGTGTTACAGTCGCTGTGGGCTCCTGAAGCCAAACGGCTGGGACCCATACCCATGAAGAAGCCTCTGCTTCCTCCACCTGCTTGTGTCGGCCCCAGGAACTACAGGGTGTGGTCAGGTAGGGTCTAGAGCTATTCCTAGCCTTAGGCTCCAAATATGCCCTCCCAGTAGCTAGGTTCCTGCCTAGAGCTGGGAGGAGAGGATCTATCCTTCAGGAAGTCATACACTGTTGTACAAAGGAGGCAGAAGCAAGGCCAGCCCTGCCTCTCATCCCATGTGTTCCAGGTGGAACAGGAGGAACTGGCCCAGGCCAGTCTCAATACTCCTGGGACCAGCAGGGCAGGAGAAGGGACTGGTCCAGGCATTGGTCCCTTCCTTTGCTCCGTGGCACCTCTACTGTATTTGATAGTCACATATAAAGTCGTCT 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@rCer/1307/0_751_CCS ACACAGGCTTGTCGTGCCGTTTAAGCTTTTGCTTGCAAGAGTGGATTGCCCCGCAATCGTTCCTGCTCTCCCGGGCCCCAGGCCTGGGGCATGCGTCGCACTGCCCGGCCCGGCGGGCTGCGCCTCCCTCCTCCGCCTGACCAATGCGACATTCCTCCCCTCACGCCCGGCCCGGTCCCTTCCAGGGCAACTCCCAGGGATGTGATGAACATGCAGGGTTCAAGTGTTCTTGGTTCCAGGCACCTCCCGGCTCATGGGGAGCCCAGAGGTCCATGCCGAGGAGACCAGGCAGGACCTCCCGAGGCTGCGCCCGGCCGGCCCATGCATTTTGTGATCCCAAGTGACTCTGTGGGGAGGGTGGGGCGGGGCGTCAGGAAGGGTAGACGGGGAGCCCCTCCCGTGCATGGCTGCCTCCCGTTCATTTTCTCCACCACAGCCGCTTGCACGTATAGATACTGTGGTCCCCTTTCTTTTAATATATAAATTATGTATGGTGAAGTGGAGTGTAATGTGTAGGTCCCGTAATTTAATGCCTCTGACTGCCTTTGAAGCGCAGCCCCCTGTGGCCCGCAGTCCCCTGAGCCTGGCTGTTGTGTGGTATTTATGCTCTCTTTGTCTGCCTGTTTCTAAGGAAATGCATGTGTGCCCTGAGCCGTGGACGATCCTCCTGTCCGTGTCGCGAGCACAGGCATTTGTGTCTGGTCTGTCCTCCCTGTTGATTGGTCTGGCATTTCCGGTATTAAAATGATAC + S,0*&+4410-$'.35051-53+455(41,0-*115161315/4.&.3%22,22/;/)9%52=/.1405*6+'71'8=<65:26038>=7952(06683'&*2577(7+.6*6"".73);=>5B4>16>49*=@?.:+=@7=19A44610)4@<3-5//75<1253/+4)3(<02:@5%050<8E->+3B:5@01*;><;/A@>7AF5CBD:3634:64.><9(0CB918957&'+1;;A6;(5%*5;<4206+(7567:&;>341:92+:?5/1='#8%62035?=EA61.<7A869A@1<<*25<1=;?723:/'C-)6<70=C)%6422>9-7:32AE7<19:;>43A1'374/0C=40,71@@>==><4?8.?980%%05=5D50-165=<:=@:7=3=5<%<@<<38<25'8=66+==-:<2:=;95B8?G56=/<144:8<1/0;>75C7(?E<(9=::7@97;B?0<=B?/>7?0E?8::>-9;?38'@D=:9(-@85&&'3:.95A6::876&;8.+30:A:7.<4;44B43-5/'//,'-48:335;+873=;8=->49.85<8889BA5,<>*?06..9=*><907/,$1 @rCer/1308/2878_55_CCS ATGGGGGCGCCTTGCTGCGGCCAAGATGGCGTCCGAGCATCCCGAGCCTCCAAAGCGGAATTGCAGCTGCCGCCGCCGCCACCTCCAGGCCACTATGGCGCCTGGGCTGCCAGGAGCTTCAGGCCAAGTTGCAGAGATCGGAGCTCCGATCCAGGTAATCGCGAGGAGCTGGTGGAGCGGCTGCAGACCTACACCGCCAGACTGGCATCGTGCTGAATCGGCCGGTTTTGAGAGGGAAGATGGGGACAAAGCCGCTCCACCTCCCATGTCAGCGCAGCTCCCTGGAATTCCCATGCCACCACCACCTTTGGACTCCCCCTTTGCAGCCTCCTCCACCTCCCCCACCACCTCCACCAGGCCTTGGCTTGGGCTTTCCTATGGCCCACCCACCAAATTTGGGGCCCCCGCTCCTCTCCGTGTGGGTGAGCCAGTGGCACTGTCAGAGGAGGAGCGGCTGAAGTTGGCTCAGCAGCAGGCGGCATTGCTGATGCAGCAGGAGGAACGTGCCAAGCAGCAGGGAGATCATTCGCTGAAGGAACATGAGCTCTTTGGAGCAGCAGAAGCGGGCAGCTGTGTTATTGGAGCAGGAACGACAGCAGGAGATTGCCAAGATGGGCACCCCAGTCCCTCGGCCCCCACAAGACATGGGCCAGATTGGTGTGCGCACTCCTCTGGGTCCTCGAGTAGCTGCTCCAGTGGGCCCAGTGGGCCCCACTCCTACAGTTTTGCCCATGGGAGCCCCTGTTCCCGGCCTCGTGGTCCCCCACCGCCCCCTGGAGATGAGAACAGAGAGATGGATGACCCCTCTGTGGGCCCAAGATCCACAGGCTTTGGAGAAGATCCTGCAGCTGAAGGAGAGCCGCCAGGAAGAGATGAACTCTCAGCAGGAGGAAGAGGAAATGGAAACAGATGCTCGCTCATCCCTGGGCCAGTCAGCGTCAGAGACTGAGGAGGACACAGTGTCCGTATCTAAAAAGGAGAAAAACCGTAAGCGCAGGAACCGAAAGAAGAAGAAAAAGCCCAGCGGTGCGAGGGGTGTCCTCTGAGAGCTCTGGGGACCGGGAGAAAGACTCAACCCGATCCCGTGGCTCTGACTCCCCAGCAGCTGATGTTGAGATTGAGTATGTGACTGAAGAACCTTGAAATTTACGAGCCCAACTTTATCTTCTTTAAGAGGATCTTTGAGGCTTTTAAGCTCACTGATGATGTGAAGAAGGAGAAGGAGAAGGAGCCAGAGAAACTTGACAAATTGGAGAACTCTGCAGCCCCCAGAAGAAGGGATTTGAAGAGGAGCACAAGGACAGTGATGACGACAGCAGTGATGATGAGCAGGAAAAGAAGCCAGAAGCCCCCAAGCTGTCCAAGAAGAAGTTGCGCCGAATGAACCGCTTCACTGTGGCTGAACTCAAGCAGCTGGTGGCACGGCCCGATGTTGTGGAGATGCACGATGTGACAGCGCAGGACCCTAAGCTCTTGTTCACCTCAAGGCCACTCGGAACTCCGTGCCTGTGCCACGCCACTGGTGTTTTAAGCGCAAGTACTGCAGGGCAAACGGGTATTGAAAGCCCCCCTTCGAGCTGCCAGACTTCATCAAACGCACAGGCATCCAGGAGATGCGAGAGGCCCTGCAGGAGAAGGAAGAACAGAAGACCATGAAGTCAAAAATGCGAGAGAAAGTTCGCCTAAGATGGGCAAAAATTGACATCGACTACCAGAAACTGCATGATGCCTTCTTCAAGTGGCAGACAAGCCAAAGCTGACCATCCATGGGGACCTGTACTATGAGGGGAAGGAGTTCGAGACACGACTGAAGGAGAAGAAGCCAGGAGATCTGTCTGATGAGCTAGGATTTCCTTGGGGATGCCAGTAGGACCAAATGCCCACAAGGTCCCTCCCCCATGGCTGATTGCCATGCAGCGATACGGACCACCCCATCGTATCCCAACCTGAAAATCCCTGGGCTGAACTCTCCCATCCTGAGAGCTGTTCCTTTGGGTACCATGCTGGTGGCTGGGGCAAACCTCCGGTGGATGAGACTGGGAAACCGCTCTATGGGGATGTGTTTGGAACCAATGCTGCTGAATTTCAGACCAAGACTGAGGAGGAAGAGATTGATCGGACCCCTTGGGGGGAACTGGAACCATCTGATGAAGAATCCTCAGAAGAAGAGGAAGAGGAAGAAAGTGATGAAGACAAACCAGATGAGAACAGGCTTTATTACCCCTGCAGACAGTGGCCTCATCACTCCTGGAGGCTTCTCATCAGTGCCTGCTGGAATGAACCCCTGAACTCATTGAGCTGAGGAAGAAGAAGATCGAGGAGGCGATGGATGGAAGTGAGACACCTCAGCTCTTCACCGTGTGCCAGAGAAGAGAACAGCCACTGTTGGGGGAGCCATGATGGATCAACCCACATTTATGATATGTCACGGTTATGAGCCGGAAGGGCCCAGCTCCTGAACTGCAAGGTGTGGAAGTGGCGCTGGCGCCTGAGGAGTTGGAGCTTGATCCTATGGCCATGACCCAGAAGTATGAGGAGCATGTGCGGGAGCAGCAGCTCAAGTAGAGAAGGAGGACTTCAGCGACATGGTGGCTGAGCATGCTGCCAAACAGAAGCAAAAGAACGGAAAGCTCAGCCCCAGGACAGCCGTGGGGGCAGCAAGAAATACAAAGAGTTCAAGTTTTAGGTCCCCTCATGCTGGCCCTTTTTTGGCCCTCCGTCTGGATGCCTGGGCTTCACAAAAGAGCCATCTCTCCCGCAGTTCCCAAGGACTTGTCATTTCATGTTCTTATTTTAGACCTGTTTTGTAAATAAAGCTGTTTC + ),,-+,&+)-+-)-+$)(*'+(-*--,-----*--,-,)(+-(--+,''*#*-&,-,*'%-(,-),-,(-(,.,--,*,),.+--,+,,.,--+)--**(-,),-',-++$(%)(+++)--.,-*-)(,%#+--*,----&+-,'*(--)+#&+#+-''+----,%,----)-.-,---*--*-'--.-*),'*',,+-+(*(+'*&('*----,-+$,-++&-,..-*((+*+,$+(*)+--,()*,,(+)$'&',(+-,(--((,)(,,),---,$&*-(,-*-'+$(+(),,.+)-,*--+*,--(,#'&*++*+$,.**,)))(',()-,,*)*(&)*#,,,,+,-.-*.---,.))(-+(,(,,&,,.,-,+*)('))%,-,)),),-(-*-.-.,.,.,+*#+.--,-.---+(+,'%)*%,(-,'+(**---,),---+(-*--,.,---.---*+%*$+)-,*)+-.,-.-*)-*'',-----+$&+*()'*,&$,+(-+-($+--+,-+'&%(---+*+-,-*,$().----*'+-----&*&*,,(,--,,*,+,,(+-)-+--'**)+(,)(,)())*',--*,(+-,----.+--(.,+,+-.,-+*-.*,--,-&--*',++($+),'(,*)&-.*.--,,,(,(('*%,,),*&-+---),),-'*,--*--,---,,.,+*+,*#,.*'',.-*++,&*(-,)*)*&',,'&),*(,-..),%)+,&,--(+*#,+-,+)''+%**)+,&&)(+-,-+()-,-----,).)),-+--+,*-+*,((+,,&,,)-,+(#*+$)(*,(($$))-,-+,))')+.--+-.+,+,,%*),+',(-)-+,(++(,.-.+(-,-,++),+(----*))),-)-,,-.,++)-,-..--),+-,-*--*---+*,%,-,(,(,--*,-*,*--+(,,--+(,(**&,*,)*)--+*-,&')++----(*)-*-...--*--.())(+--**$,,-,-*(,&*+'+&***%*++#'-*+#*-+-,++,&,-,--+&)((+'----(+++$-.,+-(,-+-)*(%,++&'-++)(..*%)-,,),+-+$++-)'*++'(*&,-*--)),-)-*,,----+---*--.,)-,,&()---)-.)*((,+-.,,)-..--)(,(+,,','*))),((-,(,,+%*-*-(,*++((,+),--),(,+,.-,.-.+-*+)-,((--.+(++)-*,(,+),.+--+,+&-)-,,,-*-----+(,---*$#','++*.,----)-.,+--+(),*(*)+)*)-,'()),-*-----------+'(+-**-,,)-.*,)(*)-*+).+)-,,-&+'-+-,%-,-**+$+.))+',-+,(-.---.,.,,,.----,-*-&()'*$*-,+&,,---'%$&(&-)-.,--'(-,-.--+&&+(*--+------*+**,+,--+.-+,*&)-*(&&''##&')-.--+*&.,.,-+--+(.,-*-,---.,---,+%,-,-(---.-,*..-+-',-,--(-,($,-,,..+*,,(*++$*,.+-#,,*----,(*',,-----.,--*,+%(($(,,%,--))-.,*,-.--.+(---,+*(+-,,..,)(--.-+&-,-*.--.*---.,(+-+,--.-,),..-,',++(,--+++$,.-,$#%-,,*$'..+++,()%.,-((,-,(%%---+,,+,&,,)),&'$*+,(-+)-+(-*,),+---*#+,,,++,$+))+(-+('-,)'---**-),*----*,*-,+-,.')),),(,+&+(,*--+,(,.-,,**)$$*$'.++))--,,((,-*--)(*),-+$,+(+)'('+())%$*---*,,))-,),&--(+)..,*-.,-)++,$*+---),*,''%,,-(&,&(,,-,'+--,*,-*++'(+),$,---(&+++(.,.--,,++&,..---($()+,-,(,-.,+*)*#*--+----,-(,),-)+-*--.,--,*+.--.+'(,,*(()-(+)),,.--+*--+)--+&)-',-,.,-+'+'%'-..))--,,--$().)-++((----+),)),+',-+-*++',*(,---*,-&-,-+),.,-+))&$,---',%&*'%'#,&--,-.--(((,---,+.-,-'-,-+),,,&)*(((,',)-).*.*)..*------.+-,,,,(+(-+--+('$$-*,*)--*(-((*+,(,----,*+(,-,,,+,)(),+,)()-,+)))--),--+---*-.*)-+)-,,)&##*-,*(+**#+----)+(*,,+++&,'),&,.+(,,--,-'&*(-,-*'&&)*+,-))-,(+--.--,+%()+-,,-.*)**$''&&+,++*+-)-,-,).,*,--+(----)---*--*)&(#+-,+&++&$),--)+--,,*'')#&(,+*&),,(,-).,.-,-'--),),+,--)+%,--,,(-*$+,,)-*-,-),)(-.--,.---+.-*&-(,$+(,.++)+.*'&+.,-'*),--.,((,&*+*-*),(+**),------((,-,(,+$+)-.,-,--*,,(+(,.+-*)*++),/-,0,/+/1%*./&..0.)-*10/01.,(-0,0-121-,/*1/01/+/10-1-/11+/1-10-.21./22.2-1.1.2/011,.1010*1101-12-1000&-200121,1/-+,+//+00)/1010+2-11+,001/.-.0-.000/1-*,21--+)(+&(,-.-,-,--,-.,),-,,,,,%+%.---.-,--,..--,-)-(-.+)-.,)$+-.--++--(,%-.,+-)''$+*+*#) @rCer/1310/25_1625_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATGTAACGGCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCTCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCTGGCAGGAAACTCTCCCACCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCTAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTT + 3;+>77=E@D:C4>67<8C=2><<>D0A@7CACDBFE7EECBEC*CB@C?EAA:E>B=:EAFF@?BD%??8;=D1F=>;?7@EC3?6>>.BCD?B?8D;DAB.@:A=7EA;@5?BAB:E8???>=3<;>A&:88#67:;B=@.B<@B?;-CF>:C=?/A-;=916B@>@;A==:D9A()=57?DGE:@;;@8=)>B@A:B;4HEEDFBC?/=C?=DD<412:066:F8>0?<1:=?54)5,<=;4?:DGDDDA@,:<@>9EB*AHD/FB;)?1=:>$5<66A6)@8.DFCE?B8B>3B@BF4D:8<:ED??JFB8HED6AB8AD=GGH/JAE/JH76FCAAFC4HF5GI;9@B>DABEDJJ?61>J4)DA=GGC9I4=B.>@7E;;175E;(GB2FFG>C@5DEEIKI??7.;?;BADIGIEK0HEKIKGJ8G9IFJKJEHKHF'DD<6-:(KAFAEIEEJD?KH?IF?DEH@>E9J;H4I?EEJKKFH=KJAHGIIBEJ*=JIHAKH?HEBDED791EI8IH*J7AH7J:FKKCKEHGJGIIJ,?KJIIGEJG?<@FIEI>5:=;6??D6;J5DEAIGEJFFIE)98E41C3>1BII9JC50HKKEGJCJ5I<C?H3IK?EAC.KKKE6I9G8JJAKJHIE3KHEC'BD:IKJIF5I1DAJ8IAAD79C>5/C%?>@?J1E@HJBJJJCHBI7EIFI+KDHJBCJJI?J>EF86IJG9I<>7:@>'@@A;A?CFIKGEJ@KA4EG77$@FIFIFHJAJKEHJJ=FJHGG9K;G;KK/HCKEJ>K@KIHJDII@?AG8K=DA>GC9E3?;GKK@JK>F8*A>?$&68?BB@IDCFJK;GFHBKJKFKI@KBHAJHG#HB@JHIIJEJB8=IK5ADG;KKHKJK4H=C?E>KF>DAI>IIEC8AG@FDDD?FHHGK582@2@>J.<9%;;?8=E?BB8D>AF97CAE=@F=C6CGA5>8A2B=E@HE>EE-JIEDHD>JHCC:7:DC=C<1::6G57H)FA=3EA469F:B@:0>=9B62HEA?D@2H)DEI:FDDHD;@4=E=D885HC%FGEC*DD&FG=C>EF>H5FCEA7HCA37D9F==0;3(D-CF:CHBF@4$;?>A<<4-=->ECD @rCer/1311/1782_47_CCS TGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGAGAGGACTGTCCTGAGCAGATTTAGTGGGGGCCGAGGCAGAAACAGATTTGGCTACGGAGCAGAGCGTCCGACTATAAATCGGTCAAGGGATTCAAGGAGTCGATGCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCATTACTAGTTAGAGCAGATGACTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGCAATTTCTGGCCAACAGTTAATGAAGCAAATGAAAACAGAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGTCTTCAGGGGGCCAGGTGCACAGACGTCCTCCACGTTCACCTCCCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACAGCTGCAGAGACAGAGGACTGGTGGCAGAGAGGACTGTTGACATCCAAGTTCCTTTGTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACTCCTAAGTAGACTTCATTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGAGCTTTTGGTATGTGAATGCGGGCTGGCAGCTGTTAAGAGTCCAACGTGGGGCAGACAGAGAGCGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCAATTAGCTGATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGCAATGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGCCTCTGGACGTCACTGTTGCCTGCATGGTGGCCCCAGAGCAGCTCTACGAACAACCTCGTTTCCAAACCAGAGCCACAGCCGAGAGTCAGAAGACTTACGCACTCAGAGCAGAAGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCAGTCACCCTTGACACTGGCTGTGACCGGGCGTGCAGCAGCGGCAGTGCACAGTGCCAGCACTACCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAACGCGTCGTAGCGAGTAGCACAGGCGTGCACTGCTCCGAATTACTCACGAGACACACGGGCTGAGCGGATGGCCCGTGGAGAAGAGAAGAGCTCTCTGACCACATCCTTCCTAACACTGCTGACATCTCCTTTTGCTCCTCCTCCCTAACCTACTGACCACTTTGATTTTAGCGCACCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCACTCTAATTCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTATATATAGCTCGAAGATGAGAGGGTTACAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGCTCTGCATCATACGTGGCCGCACCAAACAGCACGTGCTGTGACGATGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + $,054)'1#(),,-1,+,/+#3-3+32/012602&-'12.+%..232+2/*-.322.)(&''+/.$))2$41/+*,+&#*$-32+3,*.)10+/$3/*./*410*40/)/)%6.-30$$%%*'-%+.*19+7+612+/0-).+,11'51.-4)0,53,/2(6847,/.4455/'%3'5(57;9762<6$7>67*<42679(<14.0:<:8(;0/13;9124'5:.<39<-9+;3<368;76;,)68<20<'991<37>;8:4$54%:4:?@+4;:35+89<9?==-33/9)9>:7&8>:?:2363(6,6983$79,6;-8?716:;><@@420/+96;3.17670==<<9<;8?)-:+29=+2558(536'*7<3BE0?BD0A547>)=9@C<;@@1@FCBA8>=>-4>A<9->4B;BEGA@E1:'=@+?78@89;=9;07$77$9?7?25)='3)#*(7.+$<4@=39=;7,<=83>:9<3*09530+5%8-=<98395'67/14-400/8926;9-1,&*()*<8::=4//9/454/90/"3*08$-998134.%/2044/)26874(>0#./8.8:29:846874754657:7(8:/7+17/8:05.*+/.*)5$4.*3&*4/4.6:6#'35>03-6)390;811447,95--8966-*377+;7/,1;4>+(.2,09-2*724030$01;::6*027$2963671%4+5;<2<:0(/(),46%53%32.-;3362<<%9;46713(+3-702.:06;::1*5130.+3#.,=7=2:1/$3(<>8;6406+29894<-&:.<><.8-675152*234<.(703*;;+62830156;77<+66538=;'56683%>9:2>9642'3:9:+;55;&*07)6-*157(#5:,4<8<;5;4;9>>>?:00+07)=678232&24250%#6,761%0&(&%)454762..+1-54968463%3&242-6:96'6'5-,/77.9-8:3664652/,$0222932.'%./37-43+4992226,32*/41241#0*145/87/+2+)/294,65.02/'$$,*4+6'96+1733004025*)*-.//3)/4,581342,0'+(//03.*,/1'/1-)-3.$%..305333/.-&-5535&/634+4.0(.$0++.-',)-0/'...*544'536.22',/+$(+#&,%/2(201041$'*40642(/42)2)1'14'0-'&(*-10-3641.%50/&*/)0.44%28:-4>89:=863<79#1$8:$=69:;.86687;6)40:36.;/=/:=76=;//+1812'664143%2779253):86;/<84'6;<=2.73467,9.;97>8..53=251'B1B>@*6:15848+00&:.74/===779.=86:=>9.@BA;7:.<<9$>>76:<:A<9=2@;:@;5)2/423+%$&(;>9>@A;:28:3(7021<)7=;;;;=2%/:8;>7<9924+857(.<96;<<(:7685.6-,3;47::>9>>=5<7009=:9+/*46%-0486%77%-595*6:+6'9666+1>+6=86+87:61223+/2212(3:98,+,+5700/61/0,-241'2/.174-57899)1154'96&88:*.66226.0 @rCer/1313/1495_63_CCS GGAAACCTGGCTTCCAGTCTTGCAGTCTAATGACAGAATGGCTTCAGGTGTCTTCGCAAGTTGCATAGAGGTTCTGTGAACCCAGAATTCAATCAGTGAACTTGGATACGATTGGTGTGTGCTGTTGATTTGATTCTTCTGTTTCGTGAAACTGCGAGTGGAAACAGGAAGCTCTGTTTGACAGCTTTTCGCTGTGGCCTAGTTTTTAGGCAAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTACATGCTTTTCCAGAACGTTTTGTCTTGCTTAAATCATCCGGACAAAAAAAAATTGTTGCCTACTCTTCATGATTTGTTTACATCCTTAATCATGAAAGAATGAAAGAACTGGAAGAAAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGCCATTGTACAACTGTTTTAGACGAGACCCTTTTACCATGAGACCTATACGATACGAGTGATGAGCCACTCACCACGGATGACATCCCTGTGTTTTGCGGCATGCGAGTTGATTGCAAGCACCTTTGTGATCAGTGCAAGACAGGCTAAGTTGGCCTCTGAGAGCCTCCTGATGATGAGGAGGCACTGGCTACGATTAGGCTTCTCGATGTCCTGTGTGGAAATGACTGCGAATCTGAGCTGCTCGCTATCTGCAGGTTTTCCTGGCTTGCTGGAAAGAGTGATTGATCTTTTCGGTGATTCATGTACTGGAAAGGAACCACAAACATCTTCAATAATTGTGGTTGTGTGAGAGCAGAGGTGATATCTCAATGTGGCCGAGGGGTTTAAGTCTCATCTTATCGTCTGATTGGAAATCGTGTTACAAGATAAAGATAACCAAGACCAAGGAAATGAGCTGGATGGTATCCCGTTGATCTGGACAACTGCAACAATCAGTGACAGTAACCCTTCGACCCAGTGGGTGATATACGCATCCGAACCTTACTGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAAGATGGAGGAACAGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAGTGAAAAGAAGGGCGAAAAGCTGATCCGAATCTACTAGAGATACCCCTAAGCCATGAATGAACTGCATCCAAATACCTGAATATTTGGAATATGTTTCATGGATTTTTCATCTTCTCTGCAGTATGTGAAATCGCAAGTGTTTGAAGATTTATAAGTACAAATTCGGGAACTAGGAATTTTTTAGGTAGTGGAGTTTAAGTGTTAAGCTAGAAGTGGAAGTAACTGAGCGTTCTCTTGTTTCTTTGCATTATTGTAACTTTGTGGTTTGCCTTTGTCCCCTGGATAAACATGCATTTAAAGAATATTGTACTTACTGTGACAGCAGATAATAAACCGTCCTTTGGAGGGCACAACCTTATTTG + $"#%$#$%$"#%#%%$%$%%$#$$"""#$$"!#$$#%$"""%%$$$""##"#%$%$$%"!""#%%$$$$"#%""#$##$"#$"$#%#$#$'%'%%&"'('%"$&%'('%$#$$(%#"%""#&(&(%('&&''')('(%%'''%##%%$$$#'))(&(&((&$$"$')'##)''(%)*$$%)(*-),++$+**-*+,*%&"%,---,&+)%&,)&$)-*(''+*(,-(*,%*.(&')&-,(''(*&%&&&--&)'')',+(+)))-)-+-**("'*)*$(++.,-++&*+&,+-+-,(('%%&'((()'#+%'+)()(&***&)%'$*-,-+&%'#&,,++*',',(+((+,,.++'%&+-)'$)%',.+-&+--)(.*'(.,)))#*()+*#'(*,,)'%$&'#$%,),''&*)($)&(*&*'+'*&%$#$&''&"')'$&'($##&$)&%"##%##""&#""#$$#""""##&%$%""#""#&'$#*,)+--*,)+,*('#),')''+)((++))(*))%)(*(*((%(((',*,,$&(((#++*+'$((+,)&&-*++(#'(&*+(,+*'%%('$++$''*,&,&*%(&,+)%'%)'(),)()+)'(++***,''(&**,%'$)+&'')('&-**+(((&$%,$&'(%($#+*%,,+('))++$"'*+(#(**')&&')))),-,)*('&'$%%)('((',+),*)-)*)'),+*&))+,+*'"')&)+%)(+)%'&$)#,*++)**,$)'(,*-,),,,+))#"%,'+'''+%)$,+----),,),)#*)&++***+*#%#+,,,(*'*('+*%,-'-,,(+--)(*.+))%)%(',-)+-)+,(,#+*-*)%%)()#%','+)()$**,&+%$#,$*##,%+$'&%'+(*)+$$"%(&#+,%,,(#)+(*+-**))+*()+%+----,)+-+((%))$*$$((-,&,-,'),)+*'(&,*)$+(-'$+$+)**-++*,&)()+-,)-('%(*'+'+$%')+&,'))+*)*+$+,,.+(,(-)&*,($%(,+,*'*,)(%%)'$$+(,'*(*,*$,+*)),+,')#'$')'+$(*,((%,,,,,%+)*'))*#*+&+'+'*,+))+),--$,+'+$&('*&,,(,-**$+-+*)(&*(%*,-)()%'--*-,-,-&**,)**(,--)%&,),($('),+(&'&'()%#%'*&*(-+(&(+*+%$()*+&,+&++--(+*)('(,-+-+'%(((&-*(#'+).+*+*('%+-,--*),),(+*%$"%+,((+%+,(,)'*&,.,'%&*)$%,,'(((+)'#%*')--&(,-*,+*'$,-)+(-(+**''$,+++'(&$,-(+'()*%')&%*#()+)'&,),,)-.+((%#$$$'))'+%)*,,),++)*'%(',,)')-(-#'+(&$'%%#&++$*+,-(('%$%$+%& @rCer/1314/1476_62_CCS CCCCGCCGTGCGACCCGGCCTGGCCCCCGCGGGCATGGAGCCCGCCCGTAAGCGAGCAGCGCCCCCGCCCGGGCAGAGCCAGGCACAGAGCCAGGGCCAGCCGGTGCCCACCGCCCCGCGCGGAGCCGCAGTGCCAAGAGGAGGAAGATGGCTGACAAAATCCTCCTCAAAGGATTCGGGAGCTGGTCCCCGAGTCCCAGGCTTACATGGACCTCTTGGCATTTGAGAGGAAACTGGATCAAACCATCATGCGGAAGCGGGTGGACATCCAGGAGGCTCTGAAGAGGCCCATGAAGCAAAAGCGGAAGCTGCGTCTCTATATCTCCAACACTTTTAACCCTGCGAAGCCTGACGCTGAGGACTCCGATGGCAGCATTGCCTCCTGGGAGCTACGGGTGGAGGGGAAGCTCCTGGATGATCCCAGCAAACAGAAGCGGAAGTTCTCTTCTTTCTTCAAGAGTTTGGTCATCGAGCTGGACAAAGATCTTTATGGTCCTGACAACCACCTTGTTGAGTGGCATCGGACACCCACGACCCAGGAGACGGACGGCTTCCAGGTGAAACGGCCTGGGGATCTGAGTGTGCGCTGCACGCTGCTCCTCATGCTGGACTACCAGCCTCCCCAGTTCAAACTGGATCCCCGCCTAGCCCGGCTGCTGGGGTTGCACACACAGAGCCGCTCAGCCATCGTCCAGGCCCTGTGGCAGTATGTGAAGACCAACAGGCTGCAGGACTCCCATGACAAGGAATACATCAATGGGGACAAGTATTTCCAGCAGATTTTTGATTGTCCCCGGCTGAAGTTTTCTGAGATTCCCCAGCGCCTCACAGCCCTGCTATTGCCCCCTGACCCAATTGTCATCAACCATGTCATCAGCGTGGACCCTTCAGACCAGAAGAAGACGGCGTGCTATGACATTGACGTGGAAGTAGAGGAGCCATTAAAGGGACAGATGAGCAGCTTCCTCCTGTCCACGGCCAACCAGCAGGAGATCAGTGCTCTGGACAGTAAGATCCATGAGACGATTGAGTCCATAAACCAGCTCAAGATCCAGAGGGACTTCATGCTAAGCTTCTCCAGAGACCCCAAAGGCTATGTCCAAGACCTGCTCCGCTCCCAGAGCCGGGACCTCAAGGTGATGACAGATGTAGCCGGCAACCCTGAAGAGAGCGCCGGGCTGAGTTCTACACCAGCCCTGGTCCCAGGAGGCTGTCAGTCGCTACTTCTACTGCAAGATCCAGCAGCGCAGGCAGGAGCTGGAGCAGTCGCTGGTTGTGCGCAATACCTAGGAGCCCAGAAATAAGCAGCACGAGGGAACTTCCGGCCGTGCCCCGGGCCCCAGTGCTTTGCCCTGGCTCCAGCATCACTCCTCTGCCACCTTGGGGTGCGGGGCTAGATTAAAAGTCATTCATC + =B?,AC=<*AB>>2:424=7::::99;.??DDB?C;F?FAFBFGFEFE>A.>:FECB@BCB4BFBCD@@34B@AB;7>E1FEF>:DG=D?FEGDB;>@9C=EB8@FB2ACCB+==9=B$;CDE6G9AECDCE3=EEBC:AEE?->?<>AG=FGBECEAB:AAB@>;?B?6:DAAB8:?6>AB4?C2DAD0DF>DCBE4EEABB%AFC?E9?;.EGGFBCCEGFDFFA@9C@@E@EED?CBFE@DDD:E;CG?CFEFB?D@B?=DEBGBDBEF4>(8?8?6CEEFGFEGGEEGF@>CED6@DCBFFD3F9>9CD;FC:1931:CE9?DFDF1EDAE>BBD;E>BFBC4@G?@@B6FFEEE1@EDFE8CB>?AA>FFFGEE:CCCD9C@=ACFBA;?68@(?C=FE@FDFECGBEE3ECFBGCF?AFG>DFFGD5DF=EED;>A.C;8EEBFFE@;C=?5FEFA>EE8FC>F>DFFF>AFBABD@ECA@?ABBFE@;@A;?C9=A?E/ADEAEGG:@CG8BBDDB4EF?ED3CG.D:>EF@A=BG/DFFB=@<8:>>BDACA@8FE@@A-@?>FAFABE-EF=AE>D:FFF9)CFDCGFAAA?GBADC=@BFDBGDBC@:E0@FE?@E;C;F?ECB9EFGCE@?CFCGCA3938DDGEDBCC+C;DBB>?51?>%A@FE?DFDAGFFE<2AFBBAFFEE?GD@@DC;DCEC?E@BGEEGC4G3FBDFG=1:A-2E8C:FF:FCCAE@::B@?@A4@CABFGDC?BBFB6G?ECE:?BAEECBB/DEDD99B;>AC@CDBG>CGACA=GF@@A@A8B3=1@@BC>>795BA=?@C@@@AB9@>9BACB?=>A7>:@CB@;;BA;1<70@<6;@@4C@B@2B?=37>B?>BAABB7=7A7>B?A=BC>-A>5@==>><>BABA@BB?CC/B?A=A4?B1A>-?A9=BBAAC@:2<=;?=A@9?B6<88:B;$2@@5@=BC;C:A==@2A?<$9>=;A5@:6B>B@@6>==B8BA@4>B?B?C::>C?<=A>AB8=<;:ACAB>788(@@CA?@.>ABC?CC?9=B@8=@>BBA+@4@A6?7CBA9B<@B?C4;A)ACA:<2;9:5A==BC?<>>A6@@A5>=A>?A/<8=>B;6@AB4B?B7@-=:1= @rCer/1316/1923_58_CCS ATGGGCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAGGTAACGCCTGCGGAGAAACTGCAAAGATGCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCCTCGGCGGGCCGGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCCTCTAACACTCATCTTCAGAAGACTGGGACTGCTGAGATGTCCTCTATTCTTGAAGAGCGTATTCTTGGAGCTGATATCTCTGTTGACCTTGAAGAAACTGGGCGTGTCTTAAGTATTGGTGATGGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAGAAATGGTAGAGTTTTCTTCAGGCTTAAAGGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGAGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGGTCCAATTGGTTCCAAGACCCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCAGTGCGGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCTGCCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCTGTTGCTGCGCCGTCCCCCTGGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATTGTTGGAGAGAGCAGCCAAAAATGAACGATGCTTTTGGTGGTGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTTCCATCACTGACGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTGTCTGTGTCTCGTGTCGGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTTGGTTCTGACCTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGGCAGTATTCTCCCATGGCTATTGAAGAACAAGTGGCTGTTATCTATGCGGGTGTAAGGGGCTATCTTGATAAACTGGAGCCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACCAAGCCCTGTTGGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAAGTTCTTGGCTGGATTTGAAGCCTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAAATAAAGGTTCCATAATGT + ??AC$A?DCC6@>CA5@CDCBDEB?7@B@CEDCAD@9?5??E:BAE?@97=EBEAB@BC3B;CD??B=<6A8CDCC=E3=>7CC=@A4BFED@@1:5:?E::3E/=AD?<9=+D163;:8@?DC;@BD@EA>C?E?E?;FBD-<92C<2>BC=;A@A0CE@6?@?GA1BC;9D>D?FFB::@9CA*F;?@I>D4A=6FDED/DC?F;>I6A;CF7I?H@?FBAE8?3B,EGE=FGD>6F6DEHD.A>EDD6I@@CD2BFBC;8485;>DD9EHFHBIEBF@BJ@DD@8GFGEH=:HG5B:BECC?=?D<@F@EA7@FA@8G@BG=>;;?83296AA?DBDE@6<=49FAB@IF:HF:CB@D0HBG?A=H;G=B>GE8AE7CB:D6?FJCC4G>=?EAC>FFG>G:G=FD/FAA2B9B:?8A69AA>?@D?FAGED=BGD>A9,BED-@:7>?7E>?DEBE8>AEDBB=AD@CF8FG>BCCHC;@@FGCFIHIFDBCECHD>A=EFAD?>E-?=C:2<3AB/A??BEDGGIH@HE@=C3;?8DDGD9BCB7DDCA@E>7.83EAIH2IEBCEC@C=GHDD>CC6FC;>BAC;/9)FBI?A@6G;58AGDEC:8HCEBGB,C?A4DF;CAB=B?*@:BHHEC@F1I@A4AB@BGFGG8@B,GHCEE8>HEF+A4A>G=F@C>C?E>E>FABF;D;2?9@C*?D>5E@A565DBA,C?=6%8A<7D7?<;7B@@CF73>>BE>ED@?@>@D=ECBEF@596,E@=AG;<>$3>?7CBDH@HC?@BC?9>C8@>9=A;F?B:E>B0CGCBBBB;>CH;=F9A7DG6G@IB@-6/,+A2?HBACAFDGF.@:?A;EA@?-E>;H=FE;F4B9DBFH,?BGGG:D>A=@D@CH?CBC4>A2D8A@FCHB>BII02?>>9>?BGG2AAA>AA:<:AEEA<1>7<=<7B4DECBF@D=;E=DDB>BCAHDJ6HGGFDE?>FBHHFF?A8CHG=C8BE;CF7>AEFG?6:H;DF;EC<9EB*>4A;GHDI@BD?IE?F:IBE:@@JA)>C85<0B9;@61GCFE<@;AAC1GBC>?2GBDGH4@@8=69A:GEDCEBB9A>?=<8CDIIG/BB @rCer/1318/1502_55_CCS TTCTCATCATCACCAACGAATGGCTGCAGTCTGTCCAGGCCCGATGATCGTGTCGATCATCTTCAGCGTCTGTCTCTGTTCCTGTTCTTCTGCCAACTCTCACCCTCACCAGGGGGGCAGGTTTTTACATCACTGGAATCTTCAAATCCTTGCTGGTCTGTGTGTGATGAGTGCTGCGGCCATCTACACGGTGAGGCACCGGAATGGCACCTCAACTCGGATTACTCTACGGCTTTGCCTACATCCTGGCCTGGGTGGCCTTCCCCCTGGCCCTTCTCAGCGGTGTCATCTACGTGATCTTGCGGAAACGCGAATGAGGCGCCCAGACAGTCTGTCTGAGGCTCTGAGCGTACACAGGGAAGGGAGGAAGGGAAACTAGAAAACAGAAAAAAAAAAAAAAAAAAAAAAGAGCTAGCGGAAAATCCCAAACTCAAACCAAACCAAACAGAAGCAAGTGGACGGTGGGGGTTGCTGTTGATTGAGATGTATATAATATCTCCGGTTTATAAAACCTATTTATAACACTTTTACATATATGTACATAGTATTGTTTGCTTTTATGTTGACCATCAGCCTCGTGTTGAACCTTAAAGAAGTAGCTAAGGAACTTTACATCCTAAACGTATAATCCAGCTCAGTATTTTTGTTTTGTTTTTTGTTTGTTTTGTTTTACCCAGAAATAAAATAACTCCATCTTGCCCCTTCCTTTTCATCTGAAAGAGATACCTCCCTCCCAGTCCACCTCATTTAGAAAACCAAAGTGTGGGTAGAAACCCCAAATGTCCAAAAGCCCTTTTCTGGTGGGTGACCCAGTGCATCCAACAGAAACAGCGCTGCCTGAACCTCTGTGTGAAGCTTACGCGCACACGGACAAAATGCCCAAACTGGAGCCCTCGCAAAAACACGGCTTGTGGCTTTGGCATACTTGCCCTTACAGGTGGAGTATCTCGGTCACACATCTAAATGAGACATCAGTGACAACAAATCTTTGAAATGGTGCTATGGATTTACCATTCCTTATATCACTAATCATCTAAACGACTCACTGGAAATCCAATTAACAATTTTACAACATAAGATAGAATGGAGACCTGAATAATTATGTGTAATATAAATGGTTATAACTGCTTTTGTACCTAGCTAGGCTGCTATTATTACTATAATGAGTAAATCATAAAGCCTTCATCACTCCCACATTTTTTCTTAGGTCAGAGCATCAGAACAAGTGTCTAGACTCCTTGGGACCGTGAGTTCCCAGAGCTTGGCTGGGTCTAGGCTGTTCTGTGCCTCCAAGGACTGTCTGGCGATGACTTGTATGGCCACCAACTGTAGATGTATATACGGTGCCCTTCTGATGCTAGACTCCAGACCTTTTGATTTTGCTTTGCTTTTCTATTTTATACCAACTGTGTGGACTAAGATGCATTAAAATAAACATCAGAGTAAC + &$%%$%%$#$%%%$###$$$&)(&(%'%(('$#"-+((&*'(&$#%(&%"$'((((%((#')(('%('#'()((%'(()')%(''%#)('%$(#(##%&$''$'&'%(&##%'('(#'()'((('$((%()))()('$())'#')'$&&&$%(()%&('(%(&((&'#'(''(('(()')'('(#''(()())()''$($(()'()(((&$&#(&((()'%(%%$$$((()(())('(%((%(()((($%$(()(('$)')$''('&(($(%"&"#$$&#"""%'(%'%(()('(('(()())&()(()('&)')())'%&))&'+,(*+'$&,,&,,'(),,),--,),--,-+,-)(+&**%*-**+)-')))+'$'--.++)&,,++++**)(%%(++*,,,*&"%&&(+-+-.,..-*(&'&,-(+)+('''&)*&(*(((+-++%&,+%,+-%+$('**)*)&),--(&,)'&*$%',)+*)'(''*)**+-+)*+(*,(*&,--',-+()+((+,(,++-,,%,*+-*(&#*,'-+(*,----+,-(,)---#%$)+(-,-),+,-+.++-,(*+&,-).+*(+-),-(#(,*,(-,-++&+..,-+))&&,-))")&,**(*.+)'*)),+-+,$#$&'+--)+----)'%-.*(-,+%*)*(&',-)*',-),,,*%)-*))-),-,.,)-..+.,,%-,-)+*,-+*--*)$),-,-,,--')--()((+&,))),-..,---)&(.-**)---*+,$&$&,,&-+)&(&%%&$%%&++$)..,,-.,-*'))(+)(%$(-'(------.--*---..,-,'$',),-'-,').,(,---+'',(,+,#%,---,,*+(-+((,+,),,,+%-.+--.--**(&%(*+,,,,&(*+('++',-.,&)(%-)*%&,-,,-..*+&(),,(,*(,,++)*,(,',---(,---))-)*,---+(+,+)--))-+---),+,-&(,,--,)+--*-,*)((+'+,)*)'(&((%$*(+(+++%%#%+*),.,+',,--)--+(--+(-,&(--(,(-*-.-&)$,,&++,())+(*-+''&'*)%'--.*$+*.+*+----.+-'+,-&(&&(#('-)--($%)(%--*------,-,,+('+)(,'&-*---,,&'&),)---***(,--*,.,-),*--)(+**(,+)-,---$*+'#,*--(&'%&(&)()'$&+',--+'+(&*+-.))'+*(%-,,&,--.-.*--))+))$+''*'&&&('&'''),+(''++,-)),,-*-'(&)('))&#&''&'#)*'&)+$,*+())%'(*)*())+-))'+)(+++(*'-.,.),---+,,)#++'&-&++),)..,,-+-*-)--*,--#%,+&(##*-))*$(---(,*),,--)*---'*-,*''.')--)(*-)--+-,---,*)* @rCer/1320/0_145_CCS TGTCTTATCCAGCAGCCATTGGATGTAACGTTTTGCTTTGGGGTTTTTTTCTTTTGTTGTTAATTTTTGTAAAGCAGACGCTACTCTCAAGCAGTTGACAAAACTGTTTATTTTTGCAATTAAAATTATTGTGCTAAAAGCTTAC + S30*-255,5225,,&*32067..657766.7:7596;;.578-6:::672'763659434/6(4383522:83556456/126247909456627245)11.3:82802*14.8793565'188188:;49983(2679412$* @rCer/1321/0_617_CCS ATCCGGCTATTGTGGCGTTGGTGTACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGTCAGCGTGAGAAAAAGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTTAACAAAAACAATGACAACGACATTACTAACCTGTGGAGTCACACATTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTATTGTGCAACTTTACAGTAGATTTCACATTTGTTTCATTATTACAACAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAAATAAGGACTTCAATCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCTAACCCTCTTTTAAAAAAAAAAATCGGTCTTCAAAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCTTATTTATCACTAGCAGAGAGTATGATACAATTTTCAAATGTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGTTAAATGTATTT + KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8D./5HEJKHD)KD'K786H@FHKJBBDEFB9%CJB&KA@KGKKIGFKJBKKAH3I6KIJKEKCIAKJKJ4JF8KG9:KK,KKKGK6KKKJIECHHKIII%JIHKFGF:HJH:KJ=KC8A@KIJ*KKJDKJJ?KKKEKKK:KKAJEABE@D:K;I>K.KFFJA:HG>IC;KD7KK1C?HJ=KEKCJAJCK'CKH>FJIAHG0BD>9F3KA:KJJ7KK7HIIIKGIJI@=B+DGIGEDKG?@$2A>IB@EGAG@J1KJFIJFJHKJJI9KE'K=:KKGDJEJHDFK)K8KJKD?H4GHA.KKKJD=A7EKJ.KKKBKAKGKJKJCIB?@KK@H=K0:J6;JJ2JIJHJJEHA=7749)D.KKCC?CHC?H3B8=;/IJAH8ED:;:D@9KIA@9D;92=A:JKHF8H7@HFAGGHG@FJ?KKI=IEDJ6J9I:KK3KEGK?BE;#HGB=D:IF;KKC+D8IIC7GF7KHBIHIKJ-KJGGGJHDF>K6II9JKGJIFKHJKG2I=C:KJD?<(JKKJKGFIH=KKKIIJ2EKJIKGCIJJCK@KKK@I>JJI4E)K;=@AKK8KIE@F8?';BI.K)C@C8JI+GJ?0HJK>4K7EF?D28>*J5K*JJA-FKA?KKFA?K1K5K?2GIG?KKAJDJF$H:IB;CJG8H,KKK34%BEIEK0IFHJFKD;KCBJ8KKJD*JHKB*IB7FJ7GDJHKKJ=H>KKCDDIH=KE@7FKEKK5FGJFKJJFBKH5KAIKGKK7=GJGII<9B3>EGJD1KHAKHJJ?KKKKC3J?3EKKKK2KE@KGKKHJJIK0KIKIFKKKHKIIJHKKKJIGEKKJ@@DKJKKEKKFKKIF@KJGI/KKAIFKJKJJJIKIKAKKCKKKJGEKDKAGJJKKJKGKBKFIJKKKKKK=KKGKKKIIKKBK-JKIFKJKIKDI@JKJIBKEJ>KCKHD6KKKD0KKKJ=HJ9JCC7IIGKEJKKK?KKIIIKGF9KKJE8KKKJKCEKKGJK2KDJJJKKKICKG8IDKKHBKJIIIJH>HE@ADEDBIKIKJK=KK?KKE@8GKK=KA4JEE0EHIGIEEBGJEGGBIBGKICKJJKKDJJIKJHJ=2DJIF6IIG>D;?C8ACF9C@H:KIK6JBCH?IHDBK@KJJIKHA?;:AI7?IKKKJEJKKJ@KIH>KIJDJJDKJJ>K?EJ>IKJHFAGIKIGEKHAC$AGGE7EKHDHKGK:FFH>IEKDAK?BK5JGKKKEC?EFAB==GGF(IKHAKKCJGJKI*KKJFDKKKKGGFGFIEIAK;BH=FHJKJ;KJIHJJCJKKJFJD3CJKJCHFJJ1JAKFJ5IBGKEBKEEJKKKJJKJ:KJJCE@.KIKHKJKKHECJJKKJ;KJFKHJ8JKKGG>IJ9KFHHI:IIJII?KJBI.JJI6=FE-GBHDGCJCJ>DGDHJEDKKIKEIJH>IIK2IJDEKKGGHFDCJFKIJKKJJJKFKHH=%,H>HIJKJI@=HHGCBIKDFHKDJGKJJJJKJJKK9-9:>B>KJ?HAKGAFAKKGKK-IGJAE;FKFJJHGFA99CG7JIBGJJJ?KKJEIDGEGFEJ>EFJE=J,GFC;EHED:E?BB>8<>:9CEKJDKI9KEEECK@JF8HD9JJJCAHIIKHK*H@GDI>G4D759GHIGAB;F>9CFKII=AF3EEIHJH9IC8CH75KKIK@ECAJHHKEJBKJKKGHHKKJJKKHHCJHDDKDICAGKAI.H@B@GFBD.7:19@;?:&AEHBIKKJCDI@?HIFKK=KIJGJF6FCJJH1IIF=KKF>IE@>6>AG4JIIKE?FEGGJJIFJIH3HIIHEIIAK9KIHFIKKKKIJKJJKEK8IFGFKJ(FFGGJJKDKJKIKGG7F0JIIIKJAJ:FBKKKK@KFHFJEG>IJIK?JKKKKGKKKDJ=KJEKIKEJKKGJKKJHFFEKKKAE+B9DIGHKKCKIIEGKJEJDA8;EGJJE;CAE?@HKHJKIHGK6JKKKDGIG>CHKJKKJKII+FKKKHHFK>KI0KJKJKHKJ;HKAKGJIBI?GJJJ9KJG.KKKKKK?:?C;G>4;FDKJKK5HKGKIKJJ=GIGKG9KEDKJ6KII;KIGKJK7EJKE?I=KIE6JHKK'AHGKHDEAG>FK:G3GHI;KJ:<>JKKHKEHJFCKHJGKIJJKH3IKKKIJCKI=KJGJCJ?JGIIKIFK>JI8KG)JKKJFKKHH@GKHAI.IKKIK @rCer/1330/25_1689_CCS ATGGGACAGCACTTAGCACCTGAATCTTCGTTTCTCTCCCAGGGACCCTCCATTTTCCATATCCAGGAAAATGTGATGCGCCACAGGTATCAGCGTCTGGATTGCCACTTCACATCTTAGCCACAAGTGACTCAGTGGAAGATCCAGAGGCAGCAGAGGCTCGTCAGGAAGATGTCTACAGAAAAGGTAGACCAAAAGGAGGAAGCTGGGGAAAAAGAGGTGTGCGGAGACCAGATCAAAGGACCGGACAAAGAGGAGGAACCACCACCTCCTGCATCCCATGGCCAGGGGTGGCGTCCAGGTGGCAAAGCAGCTAGGAACGCAAGGCCTGAACCTGGGGCCAGACACCCTGCTCTCCCGGCCATGGTCAACGATCCTCCAGTACCTGCCTACTGTGGGCCCAGGAAGTGGGCCAAGTCTTGGCAGGCCGTGCCCGCAGGCTGCTGCTGCAGTTCGGGGTGCTCTTCTGCACCGTCCTCCTCTTGCTCTGGGTGTCTGTCTTCCTCTATGGCTCCTTCTACTATTCCTACATGCCGACGGTCAGCCACCTCAGCCCCGTGCATTTCTACTACAGGACCGACTGTGATTCCTCCACCACCTCACTCTGCTCCTTCCCTGTTGCCAATGTCTCACTGACTAAGGGTGGACGTGATCGGGTGCTGATGTATGGACAGCCGTATCGTGTTACCTTAGAGCTTGAGCTGCCGGAGTCCCCTGTGAATCAAGATTTGGGCATGTTCTTGGTCACCATTTCCTGCTACACCAGAGGTGGCCGAATCATCTCCACTTCTTCGCGTTCGGTGATGCTGCATTACCGCTCAGACCTGCTCCAGATGCTGGACACACTGGTCTTCTCTAGCCTCCTGCTGTTTGGCTTTGCAGAGCAGAAGCAGCTGCTGGAGGTGGAACTCTACGCAGACTATAGAGAGAACTCGTATGTGCCAACCACTGGAGCGATCATTGAGATCCACAGCAAGCGCATCCAGCTGTACGGAGCCTACCTCCGCATCCACGCGCACTTCACTGGGCTCAGATACCTGCTGTACAACTTCCCGATGACCTGTGCCTTCATAGGTGTCGCCAGCAACTTCACCTTCCTCAGCGTCATCGTGCTCTTCAGCTACATGCAGTGGGTGTGGGGGGCATCTGGCCCCGACACCGCTTCTCTTTGCAGGTTAACATCCGAAAAAGAGACAATTCCCGGAAGGAAGTCCAACGAAGGATCTCTGCTCATCAGCCAGGGCCTGAAGGCCAGGAGGAGTCAACTCCACAATCAGATGTTACAGAGGATGGTGAGAGCCCTGAAGATCCCTCGGGGACAGAGGGTCAGCTGTCTGAGGAGGAGAAACCAGATCAGCAGCCCCTGAGCGGAGAAGAGGAGCTAGAGCCTGAGGCCAGTGATGGTTCAGGCTCCTGGGAAGATGCAGCTCTGCTGACGGAGGCCAACCTGCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTTCTGCCCTGTCCCAGAAACTTTGGGCAGCTCCGAACCCGCTGAGGGTGCTCTCCGACAGCGCCCCACCTGCTCTAGTTCCTGAAGGGCAGACTCCTCACATTCCAGCACTTTCCCACCTGACCCCTCTCCCTCGTTTTTCCTTCAATAAACTATTTTGTGTCAGCT + I@8EGHIIADII:IBFE=CEF7?DC@IJGBIEHDII?JJG9GC>FFFGFCI+CDDE6:GE;CHI6GEHB;EE@HG@@:GHI;>GF7CC@H@@:FB>@<:C;HHGBIDE4F8C8>J0GACCJFEG7D>AF7IJD=IIIJCEBFAJFDJJ@HE=JKFA>#EIEJC8KK1IHC8K@KJH,IKGJDJJJ?=FDHHD=G:IIFE+IFGCJEGIGJHGIFIJKEC=GBFJHHHKDG5@>4KE@JGCJDEJHG8FD?GHIFDKAI7KIFDCJICKGJDCDGCIKHIGFICEHDHEDF@F1KHJF+GF@JJGGKECICIKHJEJKJI=J?F;DHEIKEF8EHF?6J0HE@HFG?CF-@JIJ=7GJHAHK8HDHHGDGB0CGJIKKFEJCJKKKJJDGIK4JFEJJKEGKIKI@GHBI8BHD@I>DHJKKJDKJKJFJK?>AEJKIFKJBGHIJG5K9IAJ=JKKKFKJEKIAKJJJJIIJJFIKJHIIHJKJKKKKEKJJKKDHAJJF?JGKAKJCJKKJFDHFIKK;KHIHJKKKKKGKKJKKJIJIGIKCJJJJJCFGKKKGJKIDFFJGKD:IHIHGKKFJJCKCJ@KHGEFFIFEEIGB@JFHKIGKJGKKKGJKKEKKKEKHK/KHEKH8KKC=JHKFJIKIKCHJKKHJKKEHKKGJKJJGAEGEJHJFK8KKKIBKKEKDKKJK9KEKKJJKJIKHD>KJIC=GEHIHKGGIII6KEIK>JIGKDKJJDHJJIJIBJKDJDGGKKEJKJ>BKJJK@JKKIFK;K8K;JAG;JDKKKEKFJAIFKKK??GCJJKHJKKKJBJJKKJIJKJJ?E02JJI7FIIJ%EA;DH6IKJKDDGFKKCGHBDHHFCKIK:CFJJ9KK>KKCCAICH0HK?GF=%AJAJK>KKKK5E=JKFKI-BKHHE(FGDFJIJIJJHE @rCer/1331/0_556_CCS CCTGGAGGCAACGGGACAATGCCTGCGGCTGCCACTGCAGGAGTTCATCGAAGCGCGTGCTGAGGTAAATGGGCTTCGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAAGGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGTAGCTTCTCCTTGGGCTCTCTTCTTGCTTGCCTGTCTCCTGGGATCAGAGGTAGTCAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGTAGC + S%%#""$%%#$$%&#&(()($##$&'%(%'((&%((&$$&&&$"'((%'"%'%%($($$%'$%%'$%&)('+-,)*#-,&.-*.+%,-,+/))'-0/2)/,,00-11002%.+.*//02(*0,)&'//,1,0)*21)+%(-,)-',/$0+0.,*-2-00/0'/10*0/-0-*0+,-/2,,00)10%.+1,110-.0,-011',-200/%0,-0/$.0/(%))**0%-*+.,'0',/00.,0,*0,/,./1*&-)*+,**%//01/.02/,(-%*.,0,0+)0/2-220,1,10+&0//022211,1,++012,,+000,1,&0/-',(,.,0)0(0*102(-0(/+/+)11210+%/-,*,+,.///,)..,20+-0.0-1002*-'1,*/*02.++-,/-210+.&.,000--0/-1102,-..(1/**+(*/.0$))'01-.&/,+,-1--/,,001(1.*+'$%,21*20,*,+%-(*+%%&*(*,0,/0*//.&++,*$'*')*(..'-1-1.10,$,)-)%*-,("%'$,&*()*)+&-..'--)(0,&)/ @rCer/1332/328_57_CCS ACATTTCAGAACATGAGTTAAAGTAGTGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCTTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGC + $'##%#**')','+11,-&2,+12-11*05-,/-/*36664/51.1602'/53/4-.3105.3./,0/-2646652..2-663/,+/214662'+(*//54//$./-11-46/4.5-/,./.551-.30135234464//.10+*$,5446-00./3).-14,2+-/*0)/5032001)150//01-/-*)+(,/5/14055002025*4-.+0(&'*$'+*'5361653134250/*42/.455,0.,3*02+(0$351462.50*0&/0 @rCer/1333/1441_65_CCS TCATACGTTAGTTTGCGCCCCCTGCCCCACTGCTGAATGAAAGCCATTTCAAAAGCGCGCTTCTCCCTCCCATCCTCTCAGCTTGTATGCTTCAGGGGCCAGGCCCTTTTTTAGTTGTGCTCGTCCAGCTCACCACCACAGCCCCTCTCAGCCCCTCAGTAGGTGGAGGGGCCAGCTGCCTCTTTAGGATCAGTTGCATCTTCCATTTATCCAAACCACTTGCCTCTCCTCCCAGTGGAGTGGGGTTCTGCCAGCACTGCCCTACCACATTCATCTGTTGTCAGCCGGGTTTTTATTCCCCAAAAAAAGCCCCCATCCAAGGCGAAAAGAAACTCATTAGAGGTTTCTTCTGCCCTTGTTAAGCCATCCCAGCTACCTTGTAAACCATCTTAAGGGCAATGGGCATTGCTGTCCCTAGCTCATTCAATCTGCATGAGCTACTCTTGGCATTCCTTAAAAAAAGTCAAGACAAGGCAATTTTTCTGCTTACTAATTCATTGAGATTCAATTTGTGTGAGCCCAACGTGGGACAAGGTGTCTCCTTCATCACTAAAAGTATTCATGAGGGTGGGTTCACTACAGATGTTGAGGGAGCAAGGGCTAGGATCACTTTTTTTAAAAAAATTCACCACTTGTGGCTGCCCAGATGTGCGGTTGTTACATCCTCCTCACCTCATAACGCAGCTTACCAAGGAAGAGTGGTTTTCCTAAGAATACATTGCTGGAGTTTGACGTTCTTCTTCAAACAAACAAACAAAAAAACTAAATACCACAAACCCCAGAAACCCATCAAACATACCATAGTAGGAAAAACTAAGTGTGTGTGCGCGCTCACGGCAATAAGAAGGATCTCTTCCCACCATAACCCTACCACTTACCTCCCAAGCCCTTCCATTAAACTATATGGAATTGGCCTGGCCACAGCCAGTCGGTCACTGGTGTGCTAATGGAAAATACACCAAGGTGAGGGCAAATGCCCCCAACATAGATGTGATGAATAGTTCTGCGAATGTGACTACTGCCACTGCCCCACACACTGTGTCTTATTTAGAACCCCTTTGCCCACCCTCCCTGATCCTCCACCTGGACACAACTTGCTCAAAGGGTGCTGGTGACTTGTGGGGCCATTCAATCTCTACAACCAAGTCCTGACTTGGCAGGCCAAGACGGCCCATAACCTAGGGTGGATGCAAGGAACGACCATTCTAAAATGTTACCCAGTCCCAGCCAATCTTATCACGGTGACCATTAACAGTTAAATTTCCCAATTGAAAAACAAGCACGAAAACAGACACTTCCAAACTGTCCTGAAGTTGCTAGCTTAGGTGTGTTGCACCAAGCAAACATGCTCCCTGTGTTGAACACTCAAGTTTTTG + &)&'&)'%$,,+"#*%&"''(+-((+(%/./.+.//-./**./(.//*+.(.+)/'///./+/.,,(-*(,'.,-..../..%%*.,'+.-%//.))',(/,++-,.'''+&)+%++..,../.....//-//'.--(-..#-$+-&(,//#*('/-/.//-,.-)/$+$)+..//.',/.-/+-./)/$////)/*./&*,..//*-//)--&,-,*./#%,-.+.,.'*,+...'*...-*)*/*,//,,)+.'/./&-,'//-///-$(-/.//*%/..)-(#)%#+"##$#$',(()%%&%%&)$)*$$"+#$++,(-..+))(-*).#///.#/./.''-,//'/&/+--))..%/.&-.-.+,,//.-)'--)../&-.-..-%'.--+'..../&-./.),.-#*--,-.'././.&/.+/.+/-//.//////(%-'-''(/*...*/*,+($'*((-+./.+./%-*..(%)'/..//*//.(.&+//,*//-//#/.,-$'--($*-.(,)-../+.+'//,-'&'-.).-/.)//)/./..*,.///++).(//(-(,.&),$./)*/../(-$$%-'*(&//.,..+*/../*//./.)$&$)(%*)*)+*/*%.-.-)//%/./,$//*,+.'-'//.-,,/$(-%..//..+-./)/../////-//)(./-&...,./*/-).--/+/),)&./,-//,#(./()///.+..)%).),)#&&'*..).*+*..+./-+..-)&('$....+.(.*#*,-$-+')*.&.)-.++.&(.*./-/*)(..**,..).(++...-.+,*%($)%*',),)#&$'''))*(,)..,.$..--..)&+*-.-*+.+)+'+,*'*-.&--'+&'(,,',-(+)*--%*+*#-,+,+,.)+)',.'+/*.(+-..+*'(-,,&.*,....),(*%,-.*,+.(.)%../...,+./+%./,+$.&*,&*$(&')&*,+'(),-(#)-)+-$'(++#%$&))+'#)$!('+'+,+('(+)*(*&(-+,,,&++#$)*("''"%%)*"%%&%')',%)()'#%,'&+&',,)$*(')')','(+,*'$++%*&&''+)*#"#%))$',+*$$&')&"'#&'&$%)'$*(&&%+**,*'*,,)*'*("$"#*&$,,$)%%&(##%)$$&%)(##)''*#(*-(-.-&*''&(&,,+*%'&#%$'#$$($'%'(%$)'&#$&'*))*&#%"(&#""%)$+*(!(&'$%$#*&'".(,&)$)*(,,.',-$(((+)"$$&##)##)+('+*#&(%&#$(&*%$)$(&$$#$&"&$$'&%#&'""'$#%#%'#*%&'$"%)$$$&#$#####&+'*)#(+&'*$####&(#&*#+ @rCer/1334/25_2524_CCS ATGGGGGCCCGCGCGAGCACACACACACACACACACACACACACTCACGCACATCTTCCAGACCCATCCCCTGCCCGCCAGCTCCACGAGCCAGAGAGAAGCAGAGCGCGAACGCCGCAGGAGGCAGTGCCTGGACCCCAGCTGCCCAGGAGAGACGGAGCCCGTGGCTGGTGAGGCCGCAGAGCAGGGCCAGGCCGGGCCCTGCCCGCAAGGACGCCCAAACCCCTCATCGGCCCCTGGGCCCCAGAGCCCACCAGGCTCTCCCGCCGGCCCCACCATGACTTCGGAGTCCACGTCACCCCAAGTTGTGCCCCCTCTCCACTCCCCGAAGTCCCCAGTCTGGCCCACCTTCCCCTTCCACAGGAGGGCAGCAGGGTCTGGGAGCGGGGTGGTGTCCCACCTCGGGACCTACCCAGCCCTCTGCCCACCAAGCGGACCAGGACCTATTCGGCGACAGCCCGGGCCTCAGCTGGCCCCGTGTTCAAGGGCGTCTGTAAGCAGTTCTCACGCTCACAGGGCCATGGCTTCATCACCCCCGAGAACGGGTCCGAGGACATCTTCGTACATGTGTCTGACATCGAGGGGGAGTACGTGCCAGTGGAGGGCGATGAGGTGACCTACAAGATGTGCCCTATCCCGCCCAAGAACCAGAAGTTCCAGGCCGTGGAGGTGGTGCTCACTCAGCTGGCCCCCCACACTCCCCACGAGACGTGGTCTGGCCAGGTCGTGGGCTCCTAGGCTGGGTGGCTCACAGGCCAGCTGGCCGGGGGGGTGGGGAGCCACACAGGGTGAACGGGCAGCAGCCAGCTCCATGCCCCACTGCCCTGGCTGATCAGTCCTTCGGTGGCCTCAGTGTGCACGTCTGTCTGTCTGTCCGTCTGTGCTTGTGGCTGTGAGCGTGTGCCTCCACCCACCCCATGACCCGTGACTACTGTGCGAGCTGGAAAGGAGGTGGGTGGAGGGCGAGGCCACCAGACCTGGCTTCTCGCTGTCCACTGCCTTTCTCCTCCCCTCCCTGCCGCAGACACGCAGGACCCGCTCGCCCTCCTACCCACCCATCCCCATGGTGACTGAGCCTCGAGAGCCTGTGCCGGGCTCACTCCCCGGCCTCCGCCCCTGAGCTGTCCCATGTCAGTCCACAGTTCTCTGTGCTACTTACATCTCCCTCCCTTGGCTGAGGTCCCCCGCCACCATCTAGACCCTTCCCTCAGAAGCCTGGCCGGTGGGTGCTTTTGGGGAGCTTCCCAGCCACTGGCAGGGGAGGAGGACAAATACAGAGGCACACAGGCCCCTCACTGCTGAGGCCAGCCTTCCTTCCTGCTCTGCTCTCAGTGCACTAGAGAGGCAGGAAGAGGGGCCTGAGGGCGGAAGGGGTTCGGGGCTCCCACTTCGCCGGCCAGTCCCTCCTCCTCAGCCTGGCAGTGGCTCTGGGCTCCTTCCCCTGGGCTGTACTGAGCCAAGCCCAGGGGTTTGCAGAGGGTGGGGGTCCATCTCTCCAGCTTGGCTGCAGCCCTCCTTTACCCTGACTCACAAGCACTACTGATGCTCTGCGCCACGCCCGGCTGACAGCTGCTGAGGATGCCGCGATGGATGGACACACGTCCATCAGGCAGGGCCGGGCCGGGGCACCCACAAGGAAGGCCCTCAGCCTGGGAGACTGGCCCTGCGGCCCCCGCGTCAAACCCTCTTCCCAAAGCCCTGACAGACCAGCGGCTGAGGTGTGGCTCTTGCTTTTTACCGTGTCCATCCCTGAAGATGTGTGACTGTCGCTGTCACCTGGAGTCCTTTTGGGGCCAAGATGTGTATGCACTTGGGGTCGTGGCCATTCACTCCCATACAGGGGTGAGAGTGGCCTGGCCCGGGAGGCCAGGAAGGAGGGCCCTGTCTGCCTCCACCTCTGGGCGCACCCCCTGCCTACCACCCTCCCTTCTAGACAGCACATCGCCTGACTGGGCAGAAGTGGGGCCATGGTTCAAGGGAGGGCCGGCCAGGGGTGGGACCCTTATGAAACCCAGTCTGTGAGTAAAACGGGGGCTCAAATGCCCAGGATGAGGGGATCAGTGACTGTCTAGGAGGATCCCTGGCCTTGTAGGTGCCCCAAGACCCCAGGGTAGAGATCAGCCGGGATGCCTGCATCCCAACCTTGCCCCCAGGGCCCATCACATAAAATCTGGGAGCCCAGAGCTGCTGAGGTATGCTGGTCAGCTCCCCTAAAATGGGCACGGCCCAGCCTGTCCCATGAGGAACAAAGGCCCCTGGCCCCTTGAGAGAGGGCTTGTTAGTGAGGGATGACTCCTCCTGTAGGGAGGCCACCTTTTAAGGTACCACTATCAGTCAGGATGTGGTGGCATCAGCCCTGGGGCTGCCTGGGTGGCAGGGGGGCAGCAGCTCTCCTCCCCACTCACAGGCCTTGCAGTGCCCATTTGGAATTCCTCCCAAGACCCCTGGCCACCCAAACCCCCCATTCTTCCTAACACTGGCAATAAACCCTCAACTGTG + DE1JKJJ2JBJBB:DJIHEJHC@CEDGCCGEEHFD@:E;HHI@AIKJKJKHEKHI:K>HJI>3CKDAEJKIGIAKKJEHIJJKEKFJIGKFKJJJJBKDGDGJJG:IHIJBHA>GDIJKGJJEKKJHJJJKKFKI7GDGBJIC;:IHEIDJHGJKJHHBI6HKICIK7HEJKCHAC8HIFJJ?CIGAFJHKE>J0JFHGEKKKJBKKCJEK:>@ECBGKBKG,IFKJ@KKAKKHFIGKBKK=DIHGJ>HIJACFEBHEH-99??0EGHGHJJKEEFBDCKKGJ:DEK9@;D9IG4KJF?HDCEGI;FFHCEII4JKJHKIJJGJ'JIBJKGKJKKFKJDKJEKKKKH+<8CJ6KIH@>JGHHD>9ADJAAGGJ:KJII4JJI>FJGKKKJHHK>JIEFHGC=H:JJJ?8KA>;I@JJJJEIII=IIKGJHKJJFKCGKK:CJ1=DFK?JKKKJGJKJJKKIFECJKKJ=IFJJKKJJDKJFIGBDKA8DCII@C%?<>=@FF7JIIIHJHEFJ?HDJ=IAH>DIFJFGGIH=F;=GEI9BJJFHJAKEFHJ:GG=?6HKIGG/9CBGHKFAFFJ7GHG8B=CGGI>FEIFHKJEDHID@ICGB>H?JAIHDGJJHKC@IIGIH7H?AAGIC<<@F?BHCEJJGKIBBIKIK2I9FHBFI:CD=9EFDJHEIKCK>JIJJEBJCHHEGI@@<=JI@BKFIA2JG=0DHCBKIBFJIHJI7HJHCJK=FHEI;FJ@IA;GEGE>9KEJKIHJKJKHFGEKJJ:GGK>IKEKH@JFJJGG;EEAI9IF?DFCCJB=FJFJIDIKFJKEKD>:BBACHAJIBEDGF5FABACFKKKGJGHKIIJKJ?JIIKKKFD=KJI@KF7KA:5=D@D=JKJFFCKKKKKEI?CHKKII4JII>KHKIEAK6KKKKKFHD1F:IHI;G@?JH-JHHIEJGDJJH?HJFGKKDKKH>?<:FBJKIFGFJIIJKHFIJ/>A@E<8?D9/7>974B?DFF=<>0?DEHGCJ?AF<9DBFJF?@7:2&DB@BEDDGECCC6DB=;46:BC<.=:AHH,7ACFEG1G4GJJG:HEB>GJHJA@FBJJKKHIIFFAG?E@BJDCFCJIJGF:GJFI8IDFIF@JFC?KEG;K9DG:EFEEGCHEKKKIFI2HJHJCDKH@G92DICGEJDJGHJHDKF:A?B1EBCIA88>FE/ADAF=CB;3A>JGCHKK9KH>/ABHAHH<4>?FFICFIIIEJ;JJHCHHHD=DG>9B;CHBC?H?<3@8*8>IE@JJI@GGFAIF>I4@9=GGIA@=;CC>CD1@D7?:0A>FJDIJII@J>ED8I&DE:9E>EJGBCK6EC=@>7DIEGI>DI:*D>@BFJJBH7AC72@6B-?@@8DBF?H2HH5GG>99G5EK5H:CGIBGGFIEHA:ECII>HFFFC6?EJJ=GG:CCEGD%;@53::29CEG>FF@;?B:FGKBH9JBC?:DIC@J7J;0GFEA(B;IKJB@,F,@8<7AB:1@98CF>D@E8FBDIIIIFIAJDCIDBI:@KI??===6>@EH2EG@GE+IDKE??>=ACIBBFJ7GC>F@1KICDD96CHDE?>=CG?I@:BFABEA+A@CA?G=KFF>?IJIIB/AFCKCJJJFJHDDEB99><>:D>@HH+@@DIJCH:G=C7KEJHC0CDICDF;A2@I;J>GIGJFGA+FKEA@CDHHGGCBAJH>::A>JH>I=K<;?)?7AF@:EG>JJ?EJGEED2BFD?JJ>DHFB32DGHIJGIFJ;CG@DF=JJGBGKI@AJIIHJKKJ?HJJDCHIGEG?IBHIJ?=HEKIFHKJEJEBG==C5IK>E=HGIHFJ=KEC1I=;FGDF5D?//C@GJHFFBJDGHEGFBEGA?@8ECF,?CI8AHE=DDEEE<>E9IBJHJ>JDD4@@ECC;GGG=EDA0HDD>@;;G>GHHEIHFH?8AIDIJJFBDH>DFK;I=37A5I?KJG8@DEH3E?A-C>/AEEKIJ5>HHDAIDHH0IC5DD7IKFHJFCEE4GD?IAIIFIA4FI9HEGKI9KJHF;@IDGB@ @rCer/1336/25_1817_CCS ATGGGGGTCTCAGTCGCCGCCGCCACTCGCGCATCTTGTTCTTCTGCGCTCAACTGTCTTAGTCTCCGCCGTCGCAATGGAAGAAGAGATCGCCGCCTCGTCATTGACAATGGCTCCGCATGTGCAAAGTGCTTTGCTGGGACGATGCACCCGAGCCGTGTTTCCCTCCATGCGGCGCCCCCGACACCAGGCGTGATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGGTGACGAGGCCAGAGCAAGCGCGGCATCTTGACCTGAGTACCCTATGGCATGCATTGTCACCACTGGACGACATGGAGAAATCTGGCACCATACTTCTACAATGAGCTGCGCGTGGCCCCAGAGGAGCACCCGGGCTGCTGACCGAGCCCTGAACCCTAGCAACAGAGAGAAGGACTCAGATATGTTTGAACCTTCACACCCGCCATGTACGTGCCATCAGCCGTGCTGTCCTTTACGCTCTGGGCGCACACTGGATTGTCATGGACTCTGGCGACGGGTCACCCACACTGTGCCCATCGAGGGCTACGCCCTCCCCAGCCATCCTGCTCTGCCTGGCTGCCGGGACTGACTGCTACTCATGAAGATCCACCGAGCTGCTACAGCTTACCACCACGGCCGAGCGGAAATGGTGCGCGACATCAAGAGAAGCGTGCTACGTCGCCTGGACTTCGAGCAGGAGATGGCCCGCCGCATCCTCCTCTTCCCTGGAGAAGAGCTACGAGCTGCTGATGGCCAGTCATCACCATCGGCAATGAGCGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCGTCTTCCTGGGCATGGAATTTGTGCATCCATGAGACCACCTTCATTCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTATGCCAACACGTGCTGTCTGGTGCACACCATGTACCAGGCATGCGACAGGATGAGAGGAGTCACCGCCTGCACCAGCACATGAAGATCAGATCATCGCACCCCAGAGCGCAAGTATCCGTGGGATCGGTGGCTCCATCTTGCTCACTGTCACTTCCAGCAATGTGGATTAGCAGCAGGAGTACGACGAGTCGGGCCCTCATCGTCCATCGCAAATGCTTCTAAATGGACTGAGCAGATGCGTAGCATTTGCTGCATGGTTAATTCAAGAAGTATAAATTTGCCCTTGGCAAATGCATACACCTCATGCTAGCCTCACGAAACTGAATAAGCCTTTGAAAAGAAATTGTCCTTGAAGCTTGTATCTGATATCAGCACTGGATTGTAGACTTGTTGCTGATTTTGACCGTGTATTCAAGTTAACTGTTCCCCTTGGTGTTTGTTTAATACCTGTAAATCTTTGAGTTCAACTTTGTACATGTGGCTTGGTCGTTTCGTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGGTGAGTCTGCATGCCAGCAGTCTCGATCTGTGCAGGTATTCATGTGTCAGGCTTGAGTGTTCTGGATTTCTCTAGAGGCTGGCAAGGGCTCCTGAACCAGTTTCTGCCCTGCCAGTCTGTCAGGGTTGGAAAGTCCAAGCATAGACCAGTTTTCTTAGCTGACGTTTTCTGCCAGAACACGTGGGCTGTTACTTGCCTTGAGTTGGAAGCGGTTTGCATTTACACTGTAATGTATTCATCCTTTTAATTTATGTAAGGTTTTTTTGTACGCAATTCTTTAAAGAATGACAACAAATTTTGGTTTTCTACTGTTATGTGAGAACATTAGGCCCAGCAACACGTCATTGTGTAAGGAAAATAAAAGTGCTGCC 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rCer/1338/25_3173_CCS ATGGGGTCATTGGCCCCGCGGTCAGGCCATACCGTGGTCTTGCTGGGGCCCGCGGTCGGGCCAGTTTCAGGAGGTTCCCGGGGCCGAGGCGGCGGGAGGAAGAGACCAGATGGCCCTTCGAGATGTGGCTGTGTACTTCTCCAGGAGGAGTGGGGCTCCTGGACACAGCCCAGAGGGCCCTGTACCGCGTGTGATGCTGGACAACTTTGCACTTGTGCCTCGCTGGGTAAGACTCTCACTCTCGACCTCGTGTGGTCATCCAACTTGAGCGTGGCGAGGAGCCCTGGTTCGTCCAGCGGAACGGACACGATCCTGTCCAGGAACACCTACAGGAGGCGCAACCCTGGTTCCTGGAGTGTGGCAGAGGATGGAGATGTTTCTGGAGAATGGCCACGAGCTTTCCCAGATACCCACTGGGATGACTACTAGCATCTTCCCGTTGCCGGTGCTACACAGTGTAAAAGCCTGCAGCGACAACGGGTGCCTCCCATCTCGGGAGAGAAACCACAGGGGTGTCCGGTGATCTACTGGGAGAGACTCCTGCTAGGCTCGGGCAGTGGGCAGCCAGCGTCAGCCTGCGATGACTCCCCACTTAGGCCTCCGAAGCGGCCAGCTTAGGAAAAGACCCTCACAGAGCACCCGGTGCCTGGGAGGCGGCCAGACCCCTGAGCGCAGAACCATGTGCACAGGAGTCCCTGGGAGAGCCTTCGGGAATGCCCCGGATCTGGAGCCACCAGCGGTCGAGGCATCATGGAATGGGTCCGACTTGGCAGGAGCCTCAGAGATCGCTTGGTGGCCAGGAACCTTCCACCTGGATGAGCTGGGCGGAGCTTCTCCCGCTGGGGAGAAGTCTTCGAATGCAGGGCGTGCAGTAAAGTGTTCGTGAAGAGCTCCGACCTCCTCAAGCACCTACGCACCCACACTGGGGAGCGGCCCTACGAGTGCGCCCAGTGCGGCAGGCCTTCAGCCAGACGTCGCACCTGACGCAGCACAGCGCATCCACAGCGGAGACGCCCTACGCCTGCCCCGTGTGCGGCAAGGCTTCCGGCACAGCTCTCACTGGTGCGCACCAGCGCATCCACACGGCGAGAAGTCCTTCAGCTTGCTCCGAGTGCGGCAAGGCCTTCAGCCACGGCTCAACCTCAGCCAGCACCGCAAGATCCACGCGGGCGGCGTCCCTATGCCTGCGCACAGTGTGGCCGCCGCTTCTGCCGCAACTCGCACCTGATCCAGCACGAGCGTACGCACACGGGCGAGAAGCCCTTCGTGTGCGCGCTCTGTGTGCGCCTTCAGCAGGGCTCTCGCTCTTTAAGCACCAGCGTGTGCACACAGGCGAGAAGCCCTTCGCCTGCCCACAGTGCGGCCGCGCCTTTAGCCACAGCTCCAACCTCACCAGCACCAGCTCTGCAACGGGCGAGCGGCCCTTCCGCTGTGGGGACTGTGCAAGGCTTTGCAAAGGGCTGTGCTGCTGAGCCAACCGGCGCATTCACACGGCGAGAAGCCCTTCGTGTGCACACAGTGTGGCCGCGCCTTCGTGAGCGCCCGGCCCTCTCCACCACAGAGGATCCATACCGCGAGAAGCCCGTCCGGCGATCCAGGGCCAGCTTGCACCCCAGGCCAGGTCTGTTCCGCGACATCATCAGAAGGTGCGCCAGGGAAGGAAACCGAGCCACTTCCGCCTCGGCCCAGCGCAGTCTCGAGCCAGGGGAGGTCTGAGGTCACAGGTTGCAGCCCTGGCCTTGTGTGAATCCGTCCACAGCTAAAGGCATATGTCCTCTGCAGATCCACAGCAGAGAAAAAGCCCCGTGTTTGCTAGTTCAGGCTTTGCTGTGATTTCATTTGCACTTGGGACAGGAGTTGCCAGTTCACCCACAGATCACACTCCATCCCCAAAGAGGTAGCACTACAGAAGCCTCATGGGGGGATGTGGTGGCTGAACTCGTAGTGGGGCCGACTATTCAGAGCCGTAGAGGTGGACAGTCACAGCACTGCACTGTGGTGCTGCTTCATGTGTTGACAGTGGGTGCTAAGGTGAGGGGATGCAGGCATGGGTTGGGGTGGCCTAGAGAAACTTACGAACAGCTGCACACAAACTGGCTGCTGATAGATGTCCACTGAGGGTATCTCAACCCACCACTGCCTCTGTTCATCCAAGGCTTCCTAGAGGCCAGCCTAGCAGACGAGACCACAAGGGGACTGGGGATCAGGGTGTGGGCTCTCAGTGTCAGCCACCTCCTCTGGGAAAAGAAAAGGTTTGGGTCCACTGAACATCATGTTTGCAGACGCTGACAGGTGGGTCCTAATGAGAGCCAACACGTGCTCACTGCCAGCTCCCGTCCTGAGTGCTGGGAAATTTCTCCTGAAGCCCTGTGAGATGGCTGCTGTGGCTGTATCCTGACTTGGAAGATGAGGAACTGACATAAAGGGGAGGTGAGTTTCCATGGCACACAGTGGAGTCGGCACCCAAGTCCGGGTGGACTGATCCGGCATCCAGATGCCTCATCTCCTGGCTGCACTCTAGTTGGTCAGGTATGAGGCCTGGCTGGCTTCACACACATAGCCGACTCAGGAGAGGGATGCCATGGGGGAACATGTGACTCTCAGCTTTGGAAGGACAGAGCTAGGATGATGGCTTTCCAGTGGCACTCGTTCAGGTGTTCGCCCAAGTCTCAGCTTGGCCAGGCCTGTCACTGACTCGCTTACCAAAAGTCGATGTGGAGAGAGCCTTTACACCTGAGGGGATGATGTTAACTTCAGACAAGATGGAGCTGCTCATTTTTGCTGGTGTGGTGCCACTTCCCCCCAGCCCTGTCTCACTTACCCCGTTATCCCTCCTCATTTGAGGCTGACAGAGAGTGAATAGGAAGGACTTGCTATTACTAAGGCCATGTGTGACACCCTCCTGAGGACCTCCCACCCAGTGTAATGGCCTGCTATGGCCGGGACTGGGGCCATTTGCTTCCTGTGCCTTCAGCAGACCAGGCTGTGTCCCTACTGGAGCCTCACCTCCAGCAAATTCATGTTCTCCTTAATGGAAAAAAAAAAAAACCCGACTAGCTTCTGCACTCGGAATAGGTGTTGCAGTTTCCTGTACAGCAGTTGGACCTCCAGAGCATGTTGTTTTCAATAACAGTTGAAAGAGCTCTCT 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@rCer/1340/25_2122_CCS ATAGGGCCCATACCCAGATTACGTAAAAACAACCGTAATATATGCTTTCATCATCAGCCTCCCTCCAACAACTTTATTCATCTTCTCAAACCAAGAAACAACCATTTGGAGCTGACATTGAATAATAACCCAAACACTAGACCTAACGCTGAGCTTCAAATTAGATTACTTCTCCATAATATTCATTCCAATCGCACTATTCATCACCTGGTCTATTATAGAATTCTCACTATGATACATAAACTCAGACCCAAATATCAACCAATTCTTCAAATACCTCCTTATTTTCCTCACTGCCATACTAATTCTAGTCACTGCCAACAACCTCTTCCAATTCCTTATCGGCTGAGAGGGCGTAGGAATCATATCTTTTCTCCTAATTAGCTGATGATACGCTCGAACAGACGCTAATACAGCAGCCATCCAAGCAATCTTATATAATCGCATTGGCGACATTGGTCTTATCCTAGCCATAGCATGATTTCTCCTACATTGTAACTCATGAGACCTCCAACAAATACTAGCCCTAAATCTCAACTCAAACCCCCTCCCACTAATAGGCCTCCTCCTAGCAGCAGCAGGAAAATCAGCTCAATTCGGCCTTCATCCCTGACTACCTTCTGCCATAGAAGGCCAACTCAGTCTCAGCCCTACTTCACTCCAGTACCATAGTCGTTGCCGGAAGTGTTCTTACTCATCCGCTTCCACACCTCTAATAGAAACAACACAATGATTCAAAATCTTACATTATGCCTGGGAGCTATTACTACCCTATTTACAGCCATCTGTGCCCTCACACAAAACGACATTTAAAAAAATTGTAGCCTTCTCTACCTCAAGCCAACTAGGCCTAATAATAATCACCATTGGCATCAATCAACCATACTTAGCATTCCTACACATCTGCACCCATGCTTTCTTTAAAGCCATACTTTTTATATGCTCCGGATCCATATCCATAACCTAAACAACGAACAAGACATTCGAAAATAGGAGGCCTATTCAAAACAATACCTCTCACCTCAACTTCCATAATCATTGGCAACCTAGCACTTACAGGAATGCCCTTCCTCACAGGCTTCTACTCCAAAGACCTTATTATCGAAGCCACAAACACGTCGTACACCAACGCCTGAGCCCTATTCATTACTCTCATCACTACCTCTCTAACAAGCGCCTACAGCACTCGAACCATCCTCCTCACCCTAACAGGACAACCCCGTTTTCCAGCCCTAACAAACATCAACGAAACAACCCACCCTACTAAACCCAATTAAACGCCTCACAATGGGCAGTATAATCACAGGATTTCTTATCACCAACAACATCCCCCCACCTCACTCCCCCAACCAGCAATACCCCTCTACCTAAAACTCTCAGCCCTATGCGCAACTGCCCTAGGCTTCCTAGCAGCCCTAGACCTCACCCTTATAACAAACAAACTGAAAATAAAAAACCCATCACAAGTATTTCAAATTCTCCAACATACTAGGATATTTCCCACCACAATTCACCGCACAATCCCCTATCAAAACCTACTCATAAGCCAAAATTTAGCCCTTCTCCTGTTAGACTCGACATGACTAGAAAAATCTATACCTAAAACAATCTCACAAACACACATCACTGCCTCCATAGCTGTAACCACCCAAAAAGGCATAATCAAACTCTATTCCCTTTCTTTCCTCATTCCCCTCACCCTAGCCCTAATTCTAATGATATAACCTATTACCCCGAACAATCTCAATCACAATATACACACCAACAAATAGTGTTCAACCGGCAACTACCCACAAATCAACGCCCATAATCATATAAGGCACCCGCAACCAATAGAATCACCCCGAATTCAACCCTGACCCTTCCCCCTCAAAAATTACCCAGTCACCAGTATCACTAAAACTAACCACCACTACTATCGTCTCATCTAAACTTAAAACCCATAAAACCAAATACTCACCTCCATATATCAACCCTACTAAAAGACCCCCTAAAACCTCAAACCCAGAACCCCATGTCTCAGGATACTCTTCAATAGCTAATGCAGTAGTATAACACAAAAACAACCATCATACCCCCAGATAAACTAAAAAACAT 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@rCer/1341/3282_56_CCS ATGGGGGAGCAGCAGCCTCCTCTTTCCCGGCTGTCACATTTCTTTTCCAGCTCTGCCCGGGAGTCAGCTCCTCGGGGAGACCATCCCCCAACCTCACCTTCCACCTGCCGCAGCCCGCTAGCCTTTCCGGGAGAAAAGGCATCCTTACCTCTGGTTGAAGGTCTCGGGGCCTCCCCCTCTGCATCCGGACCCTCTCCCCATCCCAGCCTCCCATGCCGAGGCCCGCCTTGTCAGTCACTTCCTTTTGTCATCGGCTTGGCAAACGGGAGAGGAAACAGAGCTTCATGGGAACAGCGGCAACAGTTGGTCCCACACACCTTTCCCCAAGTTGGAGCTGGGTCTGGGGCCCCGGCCCATGGCACCCCGGGAGCTCCCCACCTGCTCCATCTGCCTGGAGAGGTTGCGCGAGCCCATCTCGCTAGAATGTGGCCACGACTTCTGCATACGGTGCTTCAGCACGCACCGTGTCCCGGCTTGTGAGCCGCCCTGCTGCCCTGAGTGCCGGAAGATATGCAAGCAGAAGAGGGGCCTCCGGAGCCTGGGCGAGAAGATGAAGCTCCTGCGCAGCGGCCGCTGCCCCCTGCGCTGCAGGAGACCTGTCCTGTGAGGGCGGAGCCGCTGCTGCTGGTTCGCGTCAATGCGTCTGGGGGCCTCATCCTTAGGATGGGGGCCATCAACCGCTGCCTGAAGCACCCCCTGGCCAGGGACACCCCGGTCTGCCTCCTCGCTGTCCTGGGGAGCAGCACTCAGGGAAGTCCTTCCTCCTCAACCACTTGCTTCAGGGCTTGCCGGGCCTGGAGTCTGGTGAGGGCGGCTGGCCGAGAGGAGGAGAAGCGTCCTTGCAGGGGTGTAGGTGGGGTGCCAATGGCCTTGCCAGAGGCATATGGATGTGGAGCCACCCTTCTTGCTGGGGAAAGAAGGGAAGAAGGTGGCGGTGTTCCTGGTGGATACAGGGGATGCCATGAGCCCTGAGCTGAGCAGGGAAACAAGGATCAAGCTCTGTGCTCTCACCACGATGCTGAGCTCCTACCAGATCCTCAAACACCTGCCAGGAGCTGAAGGATACAGACCTGGACTATCTGGAGATGTTTGTCCACGTGGCCGAGGTGATGGGCAAGCATTATGGGATGGTGCCCATCCAGCATCTGGACCTCTTAGTTCGTGACTCGTCCCACCCCAACAAGGCAGGGCAGGGGCATGTAGGCAACATCTTCCAGAGATTGTCTGGCAGATACCCCAAAGTGCAGGAGCTGCTGCAAGGGAAGCGAGCCGCTGCTGCCTCTTGCCTGCCCAGGGAGGCGGTGGATGAACCAAGGCCATGCAAGCCCTGGTGACACAGATGATGACTTCTGCCACCTTCTGGGGGCCTACGTCTCAGATGTGCTGAGCGCGGCCCCTCAGCACGCTAAGAGCCGCTGCCAGGGGTACTGGAACGAGGGGCGCGCCGTGGCCAGAGGGGACAGACGCCTGCTCACGGGGGCAGCAGCTAGCTCAGGAAATCAAGAACCTCTCAGGATGGATGGGGAGGACAGGGCCCGGTTTCACCTCTCCGGATGAGATGGCTGCTCAGCTGCACGGACCTGAGGAAGGTGGAAAGCTGCCAAGAGGGAGTTCGAGGAGTACGTGAGGCAGCAGGACATAGCCACCAAGCGCATATTCTCTGCGCTGCGGGGTCCTGCCAGACACCATGCGGAACCTCCTCTCCACCCAGAAAGATGCCATTCTGGCCCGCCATGGTGTGGCCTTACTCTGCAAGGGAGGAGATCAGACCTTGGAGGCACTGGAAGCTGAGCTGCAGGCCACGGCCAAGGCCTCATGGACTCCTACACGATGCGCTTCTGTGGCCACCTGGCTGCTGTGGGGGGTGCTGTGGGGGCCGGGCTCATGGGTCTGGCAAGGGGGCCGTGGTGGGTGCTGGCATGGCAGCAGCTGCACTGGCTGCAGAGGCCGGGATGGTGGCTGCTGGAGCTGCCGTGGGCGCCACAGGGGCCGCCGTGGTTGGGGGTGGTGTGGGCGCTGGGTTGGCTGCCACAGTGGGCTGCATGGAGAAGGAGGAGGATGAGAGGGTGCTGGAAGGGGACCGAGAGCCCCTTCTCCAGGAAAGAGTAACAGCCCCAGGAGATGTTGAAGGACGGGAGAGATGTGAGGTGGGGACGAAAGAAGAGAGGGCAAGAGGGGTGAGGGTGATGCCAGGGATTCCAAGGCGCCCCCATGTACTGCACTGCCCTGGTTGAATGCTCAGTGTCTGGTAGCGGCTGAGCTGGGACTCAAGGTGGCTCTAGGAACCTGGGAGGCAGCATCTGGGGGCAGTGGATAGAATACCTGGCCTGTTTCTGGTTGCAGATGGTTGCCAATCTGCCCTTGTCACAGATAGGCTACATCCCAGGGTTTCTGGCTGCAAGTGAGGCTCTACCCTCCCCGCCTGGCTCATTTCCCTGATGACCCTGGATTGTAGGAAAGTTAAGCAGGCACCATCCTGGAAGTCTACACCTGGGTGATCAAGAGACCTTTTCTTTCACAGATGTGAGAAGCCCCAGGATGATTGACCATGGTGTTCAGGAGCAGGGAGCACTGATGAGGTGCTGGGGATAAAAGGAAGGAGGGAACACTGGGCAGAACCAGAGAGATGGGACATGGTAGGCTGTGGCCCAGACCCCAGAGCAGAGAAACTTGCTCCCATGACTCTTCCCAAATCTGCTCCAGCCCGAGTAAGGTAGCTTCCCCACCTCCTGGCCCACAGCCCCAGGGAGGCTGTCTGTGCATCCTGAACCACTCTGTGCTGGGCCTCCCCGAGGACCTCTCTTGGTGTATGCCCTTTTCAAGCCTGTTTAGATGGGGGAGTGCCCATGCCCTCTGTGAAATGCCCAGATGCCAAAGAATAACACCTTTCTTGCATTTTGAGCTAAGCCAGACAGCCTTTCTACTAGATTCTATCAAAATCTTGCAAAGGAGAACAAAATGAACAACTTCTATTCTTAAACACATCCTTTCTCCCTGGGCTTGTAAGATGATGCGGCTTGATGCAGCTCCTCAAACACCAGGTCCCCTGGGAACTGGGGGTGCAGGAGTTCTCCCTCTGGGGGACAGAAAATCTGACTACTAGGAAGACTTCTAGGCTGTGAAAACTGACTTCTAGGATATGAAACTGACTTCTAGGCTATGAAACTTACAGGGTATGGGTGGGCACATTATCCTTTATTTTATGAAAAATAAAATGTGTGTATGT 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@rCer/1342/25_1869_CCS ATGGGCTTTCCGGCGGTGCTTGTGAGCCGGTAGCCATGTCGTATCCTGCTGATGATTATGAGTCGGAGCGGCTTATGACCCCTACGCTTATCCGAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACTTGCTTATGAACGTCAGTATGAACAGCAAACCTATCAGGTGATCCTGAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAATGTCTCAGATTTGATTGACCAGAAAGTGTATGAGCTACAGGCCAGTCGTGTCTCCAGCGATGTCATTGACCAGAAGGTGTATGAGATCAGACATCTATGAGAACAGCTGGACCAAGCTGACTGAAAGATTCTTCAAGAATACACCTTGCCGAGCTGAAGCCATTGCTCCACAGTTGGCAATGATGCTGTCTTCTGATATTAAAAAGAATTATAACTACAGGCACATATATGCCAAAGTCAGTGGGGACCTTCCTTGGAGCAGAGTTTGAATCCTATTACAACTACTGCAATCTCTTCAACTACATTCTTAATGCCGATGGTCCTGCTCCTCTTGAACTACCCAACAGTGGCTCTGGATATCATCGATGAGTTCATCTACCAGTTTCAGTCATTCAGTCAGTACGCTGTAAGACTGCAAGAAGTCAGAGAGGAGATTGACTTTCTCGTTCCAATCCCAAAATCTGGAATGTTCACAGTGTCTCAATGTCCTTCATTCCTGGTAGACAAATCCAACATCACCGACAGTTGGAGGTATACACAAGCGAGGTGACCCGAGAGTGTGCTGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTGGGGCTCCTCCGCCTGCACTCCCTGTTAGGAGATTACTACCAGGCTATCAAGTGCTGGAGAACATCGAACTGAACAAGAAGAGTATGTATTCCCGCGTGCCAGAGTGCCAGGTCACCACATACTATTATGTTGGGTTTGCATATTGATGATGCGTCGCTACCAGGATGCCATCCGGTCTTCGCCAACATCCTCTCTACATCCAGAGGACCAAGAGCATGTTTCAGAGGACCACATATAAGTATGAGATGATTAACAAGCAGAATGAGCAGATGCATGCGCTGCTGCCATTGCCTCACTATGTACCCATCGTATTGATGAGAGCATTCACCTCCAGCTGCGGGAGAAATATGGGACAAGATGCTGCGCATGCAGAAAGGTGACCACAAGTCTATGAAGAACTTTTCAGTTACTCCTGCCCCAAGTTCCTATCGCCTGTAGTGCCCAACTATGATAATGTGCACCCAACTACCAACAAAGAGCCCTTCTGCAGCAGCTGAAGTGTTTTCTGATGAAGTGCAGCAGCAGGCCCAGCTTTCCACATCCGCAGCTCCTCAAGCTCTACACCACCATGCCTGTGGCCAAGCTGGCTGCTTCCTGGACCTCACAGAGCAGGAGTTCCGGATCAGCTTCTTGTCTTCAAACACAAGATGAAGAATCTGTGTGGACCAGCGGCATCTCAGCCTGATGTGAATTTCAGTCAGCCTCAGAGGTTGACTTCTACATTGATAAGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGGTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCTGAAGAAGATGGGACAGAGACCTTGACGACATATTCACACACATTATTCAGAACCTCTTTTGATATATTATAGCAGGAAGTGTTTTTGCTACCATGAAACCTTTACCTAGATCAGCATCACCTGTCAACTCAGTTACAAGTTAAGGACCGAAGTGTTTCACGTGGATCTCAGTAAAGGATCTTTGGAGC 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@rCer/1343/25_2035_CCS ATGGGGCCCTTTGCCCCGGGCGCCTCCGTGGGAACCCCGGCCGGCCTGCGCGCGCCTGCTCCAGGGTCTCCCGCCTTTTCCGCCACCATCCAATCAGATCGGCGAGGGGCGCGAAGCCCGGGAGACGCGTAGGCCGCGGTCCCCAGGCGGGTGCTTTGCATCTGCGGGTGCCCGAGTCGCGTTCCGTGCCGAGTAACGGTCTTCAAATTCAGAACCTTCGCCTTAGGGAAGTGGGACGGTCGCCAGTTTCTCCAGCACTTTCTTCGTCCAGGGACGTCAGCCTCCCTTGCCTGCTGTCCTCAGGGAGTGACAGCCGGACCTGCTCAGACGTTCACGTCGGGGCTTTCTACAGCCTTTGTGACTAAGTGCTAGGGGTGAGGAGCGACGTGGCTTATTTATGTGTTTTTCAGTTTGTTATGATTTTTTTATTATTATTATTTTACTTCTCTCTGCCTAGAATTGAGCTCCTTGAGTAAAACCCGCTGGATCGCCATCACCTAGCTTGGTGCAGGCCTGCCAGGCATTCGAAATTGTTTAAGAGGTGGGTGTTTAGTATTGATAGAGCGCAGATTGGCATTAGAAAGCTTGGCTTTGCGCCGCGTCCTTGCCACTTGCTGACAGGGCCTCCACGTGGTCTCGCGCGTCCAAAGGCACGGGGAGGCGCGTGGCGGCCCCGCCTGAGCTGAGCCCCTGGACGTGAGACATCTCGCTCTGAACTTCAAAGCGGGGTTGCAGGAGCTACTCAAGGTCGTTTTGAGGACGGGAAAAACTGCTCAAAGCCTGCTTACCTAGATCAATGGTATCGATTAACTTTTCTTTGACTCCCTTTCCACACCTATAAAATGAAGATAACGGGAAACTTGTCATACATTTGTTTGTGGTTGTGGAAAGGTCTTTATGAACTGTGAAGTCTTACGCAAATGTGAGATGTTTCCTTTCGCATCTGATTTAGCAACTCAAAACAATGAAGCAAAAACACCGAAGTCAAAAACATACACAGGAAGCAAAAAAAAAACCTCACAAAATGGTTTATCAACTGCAGAATATTCAGGATGGTGGAACTGAATGATAACTATTGACAACATAGCTCAGAAAGGACATGCTAAAGCATGCTGGATGAAGGTAACTTTGATCCAGGTCTTAAATGGAATGGACTATAGTTATAGCTTCAACCTAAATATTAACTTATGAAATCAGAGAATTAAGGCCACGTATGCCACTGTGCTCAGACTGTCAAGATATTTTAGTTTCTCAAAGCAGAAAGAAAATTAAATAATCTTGTCAACTCAACATATGGGTTGGATGATTAGCAGATCCATGGATTGTTCTGTTTATCCAGTATGTGAAGAAACGGATATCTTCTGTTTTCTTGTTATACAGAAACTTCTGTCCTTAATATGTGACTTTGAAGGTTGAACTCTAGGTAAAATTATGAAGTGCACAGTTACGTCTTGTTTATTCTTCTCTTTGTATGTCGTTTTACAAGAATCTTAATTTTATCAAAGTACAAATGACACAAGATTGTAGCCACTCCTGGAGATTTTGCTATTTTTACAGTTATTAAAAGCCATAACTCAAAGCAGCAGTTGAATCTGTTTCATAAACCAACTAAGATTTAAAAGAGCTTCTTTGGGAGGTGATGAGTTCACCAGAAACTTCTGAACTCCTCTAAGTTCTTGATTCCCATTTTGTGACCTCCCTTTCTTAGATTATTAAAATAAAATACAGGTGCTCACGCCTGTAATCCAGCACCTCGGAGGCTGAGTCAGGGAAGATCACTTGAGCCCAGGAGTTTAAGACCAGCAGGGCAACATGGGGAGATCACATCTCTTAAAACATTAGTAATTGAGCACGGTGGCACACTCCTGTAGTCCCAGCTATTGGGATACTGAAGCAGGAGGATTGCTAGAGCCTGGGAGGCAAAGCTGCAGTGAGCTGTGTACACCACTGCATTCCGCCTGGCAACAGAGTGAGACCCTGTTCAAGAAAAATAAAATGAACATTTATTTC 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12)024,3/'354%223%444+1650642**1+/'20/%*(1(/,+25102041425554-31*54111%30-'%$4,2265*22*0/2-616110,143+5/53&//14*15.65+13.205400///05360312+21%233023&,55,,+'11%2524112-5.44060#%05/2.1&3(435001,*-,-/3)/)1564+#*02/./%3+2*345,0.5/)13*'$(-0505.5-'*+,/12501/-6212532661#,.,,*11%323-04/+4361.45-53)5551.4226542%2.-,/310&*/6(02*555.0/0143,0655.514&401326651/25(+2*65.0550404462401.4354521611035215.64/3/,5642/+,&.4..,//3665.510),-/164-11+),0131/*(441-++-43450$>/5+/&-.-'/.0.-41-53$224-46/$2115//4.4-0-2'0/)$2-3%,,1/(*60443+44-3155642063)/-$/0.53..43%20*1,1631.%/4./0)2,4*22544-,%0.5162.)41/'+2+60266252)504/1(+/34&122465414,#&&(#+//003,('#--$044,/55514-13%)01/$/0/0/33.30)+1336'4102.455010230/$)-.-&$%/55111-(-/4.0251150.///6516253&1245635.$+05551$*246-5055/66650,225-64%//-02455520933297+60:6'1211137070,6830148&-.:8-/9652241431)22,:95915/..3.6$*/0/,%1,./092'491857(735&28-28/93,,08%/(113(,+6-:8+2715;9758-974694,61420;954./97-11'/2(0-.6:7;8;:060&73596%766343;554'2,2-%&,3/5/.&-/0.57+(4)538,(274543947352460771#732487542&/6671(261/+.199(/5)465774,*665.898-33535-/8088293:/028.84074363)-5691958676944221.57137.,88985,252380356:'51290-3:8658;5&6/9-7/::98;4:3/9333,545-9/7256%7/8:*464::99(-+3/.95+,/73493.44/949+1$17;59574.34;944916:803349557-,9/-0/-18.'6'5435.&0355'90446&)#1%2'/)-.,5,1741.-12530917+20,/,,2+.-772,84.63$/8/:65.44&53.63644/6/92:69695361454&464&78314856321(46534864:2&67*05;4344316715485584621,/%2;:81,26151&10283/).&08::4-.32.537553998-55723301228:54645721-04:826.3214345445%*-$,092919099985-&31513/'02.,)236/102-30+2/+52.-(40$7187'87442$4/7986495257.(4+687549945642-.8:95,/37)(735:8998/13..,)23+3,4,30952466'23-15541:5-:7*952/366136+&-0-66:3-/6/6/7341-92.-5204541216/:835608:4)-.34178,44/44)6874:366&46/9,673735538458-*1$*/,4410-00-00+'-*.11+.10-++)-+/1-+-/*&++*+*#%&((*,+.,%/--+.00(0*#+%*,.).&+)&00-211..22211../)(-,.,-$+,022.0.0)00'&$(0.,-,*'10*,+',/00&.)+-,,('+,)))++$+'+,&(,,+)+---+#+))-,+-(')),-+(+)$+)*++#&-+*+',+'&'(&&%,+'$)%&$%*,*(+-,,-(,$()&**"(*)+'&%),,+(',++,$,&',&#(**+,%+*,,+$,*((+,,*--+ @rCer/1345/2355_56_CCS ATGGGGACCGTGCTCCGCCGTCTCCGCCGCATCTTCCACCCGCGCCGCCGCCGCAGCTCCCCGCGCTCGCGCCACCGCCGCCGCGTCCACCCTCAGCGCCACCGCCATGCGGGAGATCGTGCACCTGCAGGCGGCCAGTGCGGCAACCAGATCGGGCCAAGTTTTGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGGACAGTGACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGGAATTATGTCCCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCCGGCCCCTTCGGTCAGATCTTTCGGCCCGACAACTTTGTGTTTGGCCAATCCGGAGCCGGCAACAACTGGGCAAAAGGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCCGTCCTGGATGTAGTCCGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGCTTCCAGCTGACCCACTCGCTGGAAGGTGGCACGGGGTCTGGGATGGGCACGCTGCTCATTAGTAAGATCCGCGAGGAGTTCCCGGACCGCATCAATGAACACCTTCAGCGTGGTGCCCTCGCCAAAGTGTCGGATACGGTGGTGGAGCCCTACAACGCCACGCTGTCCGTGCACCAGCTGGTGGAGAATACGGATGAGACCTACTGCATCGACAACGAGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGACCACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACACCTGCCTGCGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCAGTCAACATGGTCCCCTTTCCTCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCCCTGACCAGCCGGGCAGCCAGCAGTACCGGGCCCTGACGGTGCCTGAGCTCACCCAGCAGATGTTCGACGCCAAGAACATGATGGCCGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTACTTCGTGGAGTGGATCCCCACAACGTGAAGACGGCTGTGTGCGACATCCGCCCCGCGGCCTGAAGATGGCTGCAACCTTCATCGGCAACGGCACGGCCATCCAGTGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGATCTGGTATCTGAGTACCAGCAGTACCAGGATGCCACTGGCCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAGGAGGAGGTGGCCTAGGCTGCTCCCATCGCTTCCCATCTTTCCCCTTGAGGCTTCTGACCTTGTTGACCCCCTAGGCCCCCCATCTCTGACCCTGGAGCCCCACTTTCCCTCCAAGCCTGACTTCCCTGCAACCGTAAGACTTGGCCCTGACCCTAACAATACCTTTGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCAACCCTGGCTCCCCTTTGACCCTTGAGCCCCAATTTATCTTTGACCCTCTTGAGCTCTTCCAACCTTGACATTCCCAGGAGGAGCCCCGCTTCACCCTTCTGACTCTGGGAACGCGCCTTTAACTTTGCGGGTCCTCCTTCACCCCTGACCTCTGCTTCACCTTTGACCCCTGCCCCCATGAATCCCATTTTACCTCTAGACCTAGAAGTTCTGGTTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCTCTGACCTTGCCTCACCTTTAACCCCATCACCTGAGCCCCAGCTCCTACCTCTGACCTCAACTTCTCTTTGACCTCTGAATCCCCTCTGACCCCAACTTCTCTTTCACCCCCATGAGTCCCATTTTACCTCTACACCTGTAAGTCCTGGTTTTGCACTGGACCCCTCCCTCTGAGCTGCAGTTCACCTTTGAACTTGCCTCACCTTCCACTCCCCACAGCCCCAGCTCCCTACCTCTGACCCCTGCTTCTCCTGGCTCCCACAGGCCCCATATGCGTCCTCCCTGCCTCACTCCCCTCAGCCCCTGCCGACCTTAGCTTATCTGGGAGAGAAACAAGGCCCGGTTCCTGTGAGGAGGAGAGGTTGCCCCTGCCCTCCCTTCCCCGCATCCTGCCTTGCCCTCAATAAATAAAATTGATTGTTGTCCT 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TGGGGGCGGCGGCGGCGGCGGCGCGCGCGTGCGCGGGCAGTGAGTGTGGAGGCGCGGACGCGCGGCAGTGGAACTGCTGCAGCTGCTGCCGCCGCCGGAGGAACCTTGATCCCCGTGCTCCGGACACCCCGGGCCTCGCCATGGCTGACCAGCTGACTGAGGAGCAGATCGCAGAGTTCAAGGAGGCCTTCTCCCTCTTTGACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTGGGACAGAACCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGGAACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACAGACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAACGGCTACATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGAGAAGCTGACCGATGAGGAGGTGGATGAGATGATCAGAGAGGCTGACATCGACGGAGATGGCCAGGTCAATTATGAAGAGTTTGTACAGATGATGACTGCAAAGTGAAGGCCCCCCGGGCAGCTGGCGATGCCCGTTCTCTTGATCTCTCTCTTCTCGCGCGCGCACTCTCTCTTCAACACTCCCCTGCGTACCCCGGTTCTAGCAAACACCAATTGATTGACTGAGAATCTGATAAAGCAACAAAAGATTTGTCCCAAGCTGCATGATTGCTCTTTCTCCTTCTTCCCTGAGTCTCTCTCCATGCCCCTCATCTCTTCCTTTTGCCCTCGTCTCTTCCATCCATGTTTCCAAGGCCTGATGCATTCATAAGATGAAGCCCTCCCAGATCCCCTTGGGGAGCCTCTGCCCTCCTCCAGCCCGGGTGGCTCTCCTCCATTTGGTTTGTTTCCTCTTGTTTGTCATCTTATTTGGGTGCTGGGGTGGCTGCCAGCCCTGTCCCGGGACCTGCTGGGAGGGACAAGAGGCCCTCCCCAGGCAGAAGAGCATGCCCTTTGCCGTTGCATGCAACCAGCCCTGTGATTCCATGTGCAGATCCCAGCAGCCTGTTGGGGCAGGGGTGCCAAGAGAGGCATTCCAGAAGGACTGAGGGGCGTTGAGGAATTGCGGCGTTGACTGGATGTGGCCCAGGAGGGGGTCGAGGGGGCCGACTCACAGAAGGGACTGACAGTGGGCAACACTCGCATCCCACTGGCTGCTGTTCTGCAACCATCCGATTGGCTTTCTGAGGTTTGGCTGGGTGGGGACCGCTCATTTGGCCACTCTACAAATTGGACTTGCCCGCGTTCCTGAAGCGCTCTCGAGCTGTTCTGTAAATACCTGGTGCTAACATCCCATGCCGCTCCCTCCTCACAAAGCACCCACCGCCCTGAGGGCCCGTCCTAGGAATGGATGTGGGGATGGTCGCTTTGTAATGTGCTGGTTCTCTCTTTTTTTTTCTTTCCCTCTATGGCCCTTAAACTTTCATTTTGTTCAGAACCATGCTGGGCTAGCTAAAGGGTGGGGAGAGGGAAGATGGGCCCCACCACGCTCTCAAGAGAACGCACCTGCAATAAAACAGTCTTGTCGGCCACTGCCCAGGGGACAGCAGCTACGGCAGCCTCTGCGTCCTGGTCCGCCAGCACCTCCCGCTTCTCCGTGGTGACTTGGTGCCGCTTCCTCACATCTGTGCTCCGTGCCCTCTTCCCTGCCTCTCCCCTCGCCCACCTGCCTGCCCCCATACTCCCCAGCGGAGAGCATGATCCATGCCCTTGCTTCTGACTTTCGCCTCTGGGACAAGTAAGTCAATGTGGGCAGTTCAGTCGTCTGGGTTTTTTCCCCTTTCTGTTCATTTCATCTGGCTCCCCCCACCACCAACCCCACCCCTCCCCGCCCCCCTGCTTCCCCTCACTGCCCAGGTCGATCAAGTGGCTTTTCTGGGACCTGCCCAGCTTGAGAATCTCTTCTCATCCACCCTCTGGCACCAGCCTCTGAGGGAAGGAGGGACGGGGCATAGTGGGAGACCCAGCCAAGAGCTGAGGGTAAGGGCAGGTAGGCGTGAGGCTGTGGACATTTTCGGAATGTTTTGGTTTTGTTTTTTTTTTAAACCGGGCAATATTGTGTTCAGTTCAAGCTGTGAAGAAAAATATATATCAATGTTTTCCAATAAAATACAGTGACTACC 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@rCer/1349/783_57_CCS GGTAGCGTCAAGGACTGAGATGCCGCGACTTGTGCAGTGTGGTGTTGTTCATTACCAGTTGGGCTGCAGGGTCAACGTCAAGCTGGGCTCCTGACTATCGATAGTCCGGCCGACGGTGTTTTGCACTAGGTCTGTACCCTCCTTGCCTAGCCTCGGTTATGTGGGGCTGCTTTGTCGTTCCTGGAAGGCGCAAGGAGTTCTCTCGTTGCGCGGTCCCTTCTTACTCAACCAGGCGTAAAATTGGTTAGCCCAGTCGTGTTTGTAGGGTAGGGTGCCGATATGTTTGAGCATATTGTAAACAACACGGAGGCAATGATAGCACTGTGCTCGTATTCTCGTGCTTCCTGGATGGTGCGCGGTGCTTCAGTGGCTACTGGTGCCACGCCCAGGTGCATGGCACTCTGGCGTTTTTAAGCTGTTTCAGTACTGGGTTAGTAGTTGAGATGGTGGGGTCTTGCGAGGAATAGTGGACTGGAGGCCCACTTCAGGGTTCTCCTTCTGCCTCTGTGGAAGTCTGTAAGAGGGCATTCCCCTGGTGCTTCCCCAGAGAGTTTGGGGTGTCCTTTTGCCGGTGCACGTAGCTGCGCTGCGCAGCGGGCCGGATGTGCTGCTGCTTATGTAATCTTCAGCACTTGCGTGCTGCCTTTAGTCTCTGATGTATAAGAAGGGTGGGAATAGAGACAGCATGTCGTGCTGCTTCGTATATAAAATAAAAAAAAAATAATT + 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ATGGGGGGACGCCGGGGTGATCATGGACGCTTGACAACCTGCGGGCATTCGCCGGCAGGCCGAGCCAGCGACTAAGAGGACCGAGAGGTGGCTCGGACAGATTTCAAGGCCAGAGAATGGCAGGGGAACAGAAACCCTCAAGTAACCTCCTGGAGCAGTTTATTTTATTAGCCAAAGGTACCAGTGGCTCAGCCCTCACTGCTCTCATAAGCCAGGTCTTAGAGGCTCCTGGAGTGTATGTCTTTGGAGAACTTCTGGAGCTGGCCAACGTGCAGGAGCTTGCGGAAGGAGCTAATGCTGCTTATTTGCAGTTGTTGAACCTGTTTGCCTATGGGACATACCCAGATTACATAGCCAACAAGAAGAGCCTGCCAGAACTGAGCACAGCTCAGCAGAACAAGCTGAAGCATCTTACCATCGTGAGCTTGGCATCAGAATGAAGTGTATCCCCTACTCCGTGTTGCTGAAAGACCTGGAAATGCGGAATCTTCGGGAACTAGAAGACCTCATCATTGAGGCTGTCTACACTGACATCATCCAGGGCAAGCTGGACCAGCGAAACCAGCTGCTGGAAGTGGATTTCTGCATTGGCCGTGACATCCGAAAGAAGGATATCAATAATATTGTCAAGACCCTGCATGAATGGTGTGATGGCTGTGAAGCAGTTCTGCTGGGCATCGAGCAGCAAGTTCTGAGAGCCAACCAGTACAAAGAGAACCATAACCGAACTCAGCAGCAGGTAGAAGCAGAGATTGCTTGTTTTCAGAGGGAAAAACGTGAAGTCCCCCTCCTGAATCTTATAACAACAGCTTTCTTCTGGTTACCAACATCAAGAAGACACTCAAAGCCACCGCATCCTCCTCGGCTCAGGAGATGGAGCAGCAGCTGGCTGAAACGGGAGTGTCCGCCTCACGCTGAGCAGAGGCAGCCCACCAAGAAGATGTCCAAAGTGAAAGGTCTGGTCTCCAGCCGCCACTAGGGCCGGCTGGGGCAGCTGGCACTCACCAGGCCTGGTCAGGTGGGGAGGGGACACCAAGGGCCCATTTCCTCCCCTCTCTACCTACAGTGAGTTCCAGACCTGCCCGTCCCTCACCAGCGCCTCCCCACCCTGTTGGTACTGTTCCAGAAAAACTGTTAACTCCCCTCACCCACTCCCTCCTTCCCCAGTTGTTCCCTTCAGACTCAGGGGCTCCACCGATGCCATCCCAACAGGGTCAGACACTGCCCAGCTTCCCTCCAGGAGGTTCTTGTCTCTGTGTAAGGGCTTGTGTCCCTCCCAGTTTTTCTTTTGCTCCATGTCATTTTGTCAGGCTGGTTATAAGCTGGAGGCAGCTTTAACCAGCCCCCAGGGATGATTGTGAAGGAGGCCCCTCCCCTTGTGAGGAGGGGGCGCTCCTCTCCAGCCCCTCGTACCACAGTCCTCACGATGGTGCAGCGATCTCTAGCCAGGCGTCAATATGCGCTGCTTTCCGTCTCTTGCCTCATCCTTTTTTGGCAGCTCCAGTTCAGGCCGTGGAGGGACGTGATGCTGGGCTATGTTTACTAACCCACGGGTTTTCAGCCTCTTAAGCCCAGCTCCGATCTCCAATTAGTTGGGAGCGCTGGGTTGACTAACCTCTGGTATCTGAGCACAGACAGAGGGTGCTGTGGGTCTGCTGGGTGCAGAAATGGTTCCTTCCAGCGTGGCGTTCTCTTCTGGCCGCTCCTCCTGCTGCCTCTGACTACTCAGCCTTGTTTGGTGTGTAGGCCCAGCTGCCCACTGGAACTGCTGGCTAATGCTTGCTCTCCCGAGATCTTTAACTCCTCCTGGCTGCACCTGGGTAGGGATGGTGGCACCGATGCCCCTCTGTCTGCTGAAGGACCTGTTGCTGCTTCTGTCTTTTCACCCCTCCTTGGCTGATGACCCAGAGCCCTCTGATGATGGCATTCTCCTGGCAAGAGAAAAGGACTTAACTAGACTTCTGAACTTGAACAGTTTCAGGTTATATTTTAATTTTTTTTTGTACAGGTTCTGATTCTAATACATTTCAACATGGTTTTGTC + 9205;<;&=9>:7;36198=78:8=79;19:6;;9=2:734995770<74,.)6/>;;:<>>=614/1&2;9538923;3.04:/5:7::>>>;7<832<04)7808==?==?;<:9>?271=4=<<6:?59<4/;3=5?>944$.)553-7<51.6;3>::>229=<9>=::67=:?<:829:42886256;12)1-+:685743997;9=:9:609?8;7*79;<;<86:8;;;76.,=5:7>=5972669273:838/2>87=2,01.,*08+789;=654.7<5:4954<(34*017<7299827>833:6:*883739+5:0:=:;0.836=5:986>876;6754437523166<;93;,7:7717;99>6104*3414;798/;9<==8;99<43$733=6?<;59917>;<095619;;<:>6=87977)8-<3978:96=?=86?75>4;5776<689777(229667/98052:141591484975665.1,,12330/16+9929765+*67::95:149043697.7;55*3531990/:6:47;681959426.6:57898449376/2+..:489041864566.217153./388;898-9620'836835-77.61/460803837:1.4673157::58562143324/3641--.+4939962:::;58,46166195688763,40::51::9943374519:2&1-02/25&561476*5444+798:97769:72-4:5503%'00&-57,7547:8367,39-95.,/,15,5.6636909:1117250476'59958'8:8:;:955.163-035839511:-*030/2)-22'*26644&)05/649:19.881746:76159-+..+-'3448900:66053*225978766)68568.415625732/453461166550045.758273/23(-+::3943)-//67707*2.38'5-99859;54+224%377949/474:.6255+935586,84244,:258:7766.)7'664//02/03--1,0.)*/+-&#-0,./-220'1/-.1.)+/+*+*%'0,2*%*)(.6%48-80321'396+47434260,8:.:8894898-851/4688;/71:90965::894&.35225,15/2626/4/.2-644.-1838342/934%,.48746828:616-624020678/9:6:773175::1--&2/536525799352256+5848+373927+788126/',/4-4,.764*8457+.2,963:/2:815:-8495416853-6:82+/:736016799/982878)6527(614)47;7599:30.032:75)-4-,-486$45//55'-6.0766.*89652796023/497:865367;:793698-439853/.88.9682:549*3:345:+369-1.65989,7/:688165603422./9482463966/83--/4+/-25((.#+-,5(14-/**(+++113535.4:657974.1)285//3*13,06535418203233,.4.23-/549736645886)3640./+54.79.-'134039:696/)&25909/.8*424124+0-3)22406')2'0--.1133-+.0/)$**4140*64334+521.5/1.5699:7562797--5/0-*04+'.62357+63..7:8:7286+966:67./312//1).*,98:548;8889;56178/+1%668687:4(/,95473594:1/4-128+32218726-((60(400)3-5,76612,04/359-95;8;8831=>==>522094++3.70255323/159.3744-:4657.602356930:;9936168459.983542/-+358325-568741(9-5:79248032+16*797;8520/./94:64.38735.550667(:7:249792:272,+2:2:2436.95;3730+;:796=9.>=9;7=>71132 @rCer/1354/25_1588_CCS ATGGGGAGAAAGGAGAGAAAGGAAAGCGCGAGGAGACGCCGCCACCACCAGCGCAGCAGTGCAGGAGCTGTGAGGAGATTCGGGCAGTCACCCCGCCTCCCCTGCGTCCCGCCACCAGCCGCCTCCGTCCTCGGACCCATTCCAACAATCTCTTAAAACATGGTGGATTACTATGAAGTTCTAGGCGTGCAGAGACATGCCTCACCCGAGGATATTAAAAAGGCGTATCGGAAACTGGCACTGAAGTGGCATCCAGATAAAAAATCCTGAGAATAAAGAAGAAGCAGAGAGAAAATTCAAACAAGTAGCGGAGGCATATGAAGTGCTGTCGGATGCTAAGAAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGTGGAGGAGGAGGTGGAAGTCATTTTGACAAGTCCATTTGAATTTGGCTTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTTGGTGGAAGGGACCCAATTTCATTTGAATTCTTTTGAAGACCCTTTTGAGGACTTCTTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGAGGGACGGGGGTCGTTTTTCTCCGCGTTCAGTGGATTCCCGTCTTTTGGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGGTCACTGGTCATGGGGGCCTCACTTCATTCTCTTCCACGTCATTTGGTGGTGGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACTAAAATGGTTAATGGCAGAAAAATCACTACAAAGAGAATTGTCGAGAACGGTCAAGAAAGAGTAGAAGTTGAAGAAGACGGCCAGTTTAAAGTCCTTAACAATAAATGGTAAGGAGCAGCTGCTGCGCTTGGATAACAAGTAATTCAACGCACGCGCTTAACAGAAATGTTAAACTATAACAAGCACCATTTGAGGATTAACAGGAACATTTTTTTGAAGATTTCAAACGAACTCGACTTTCAGTATAATTGTACCTAAAGTATTTATAAACAGCTCATCGGAGCCTCTATTTGTCATAGACTTTTGAGTTTATTGTTGGGACCACATAATAGGACCATTTTTTTTTTGTCTTTAAAATTGTTGTAAATCTCTGTATGCACTTTGCTTTTTTATTAAACGTACTCCAAGGTGAGTCTTGACTCTTTAGTGTAGGACAAGATTGTACACTAACACCAGCATGGACCTGCTTTTCATTGTGTCTGAAATGTGAGCCACGTAGTGTCGGCCTGCTGTGAAGTTAACATTACCAGGACGATTCTTCTACAGAAATAATTTCAATTTTTTTCAGTATTTAGTAGTGAAAGATATTAATGCATTAATGGTAATACATTTCTGGTTTAATATAAATTAAGGATGTTTTCTAGTTGTGCATGAATGCTGGCAACTTAGTAAGTTTTGACAATTGTTTAAATATGTAATGTTAAGCTTAGGTTTAAAAAAGTAAAGCTTGGTAAACTGGGTCTTTGTCATTTGCTTTTAAAAAAAAAAAAGAAAATAAATGCGAATGTGTTGGTGCATTCTTCCTGAGTGGGAT + .*$1./.,+16/1-30515404366044642.31/*10-,/151/1&/2/3435051'243/42-&2224*-/431/-/54/234542+.)20343552644..051(-/..3-)1.-/020455262.501(3126///115235.2/1.*)0)35212/.3313.*01335.0244563+./653.03423.01/3.351,)-44411..-112)00/.*0..0/01.*%0/.'&./11.01.01&/,.))/.0.0&0.-,'')--+)-$,*(/0+&001/+/010&*+)+.0*.01/20,1+'+-1/2/-0//10-./210-.1.+,-0+/1.1+-%(01/-21000.0),-++))//.,+*/*+12.-21/,-,+,,.00/)1/-0+',**//,2.*/1.+$.+/+--$*,)*0-'--)'0,/1/0/,0//0+$0*.0/*1%)+**/,((.,+('0.,**1*/$*--+-00-+../.-+.+)-.$%'.*.-0/0-..)/+'.++,-1'**./)1.-..-0/1...(*,),02(/.-0(0-00//-0/0.*.--00/),$,))...-./),%,/..*.-%,---++),0/))//1)(**--/+0,&((*/12/0&0//,0/$00//+2/&1,...++,1../.000/-0/0*+/'-.,/0/(#**+./(11/1,2//,0121--.+0/&+,/&+'+/1(,.(.'.0*.0/+0/(,)/-'),+)0&+.0/1--)+/*%/.--..2/)(22//00.2.0&)/-.*-202.0.11/+-'&0/001++0./-,'*&*/.20,)-/'/0100.+''--)/-)/..0,,/02/010$+&'-...120.*/./0,).0.+,.00020010/101.,*.,-,/-+--.00+00-)+/.+%--+,,,(.0.-2+///*(0./,,/)+/--01-.///&,,+,-.00/--1,.,0000,0*.,,%///2445*400$42125624453.1*..)3335/-)30/*3344354.42.10*03/1-163461.,(/-*52556+31456300414//1.%012201//64054/6,222.3-03*05//-3.111%1/1.13444443%32&3221/2.4..-04155314302311404410/50-44035366.0(+3//403354544335+4,/1.+053335/3-60/-0-3455.24/03-42-00-.1/,1422414.'23/)2/622,-214/664240,,'/,2340413-+0645-0&254/*..0403/,,2311-.2031//3.-/.11(550651*2)2.--3%-33110//31*%43054.150&,11...4616221/362-('60+3-+00162215356634104/564306155/0'2320/./$40/.3.21'21$04/4-023.5155/60%544415/4245/36.40//641135253-4,0*1254%2-+135422513004$',0,(1002-4204.51216316621%22$#/02012/10./+(-050'212/30-42.11.4/610300631303-13/1.4131 @rCer/1355/25_1807_CCS ATGGTGCGAGAAGGGGTGTAACTGATTTAGGAAACCAGAGGAAAGGCGCAGTTTTCACCAAATTGGAATCGCGGGAAAATAGAGATGAGTTTGTCTCAAGGTCTCGCGAGATCGAGACCGAAAGTTCTTCATCTCAAGCATCAAATGCTGAAAGCGGCCTGACTTTCTCTACCGGAAGCCCTTTTCCAGAGGCTGGGAACACGGCCCACCTGGCAGGAAGTCCCACCTCCTTGAGCTCCGCCACCCTTCCCGAAGTTTTTTCTGTCACCTGTGTTAGGCTCCGTCCCCTTTCCCGGTTTTATCCCGTACCAGAAAAGGATACATTTAGTGCCTCTCACCCAGCTCCACTAAACGGGTTGGATATCTCATTCTTTGAGTCGGGGTTCCTTCCCCGGCGCCTCCATGTAGCTGGGAAGTGGGACCTGGGGGTGGTTGGACCCCTGGGATCCTAAAGGAGGGCAGGGAGGGCGCAGAACTCCGCTTCTGCTCCTTGCTACCAGGACGAGCGGCCTCCTCAGCCTCTTTCCTCCCGCTGCCATGCACCCTGCAGCCTTCCGCTTCCTGTGGTTGTGGCCGCTGTGCTGTGGGGAGCGGCCCCATCCGGGGCTCATTCGAGCGACCTCGGACCACAATGCCAGCATGGACTTTGCAGACCTCCCAGCTCTGTTTGGGGCTACCTTGAGCCAAGAGGGACTCCAGGGGTTCCTTGTGGAGGCTCACCCAGACAATGCCTGCAGCCCATTGCCCCACCACCCCCAGCCCCGGTCAATGGGTCAGTCTTTATTGCGCTGCTTCGAAGATTCGACTGCAACTTTGACCTCAAGGTCCTAAATGCCCAGAAGCTGGATATGGTGCCGCTGTAGTACACAATGTGAATTCCAATGAACTTCTGAACATGGTGTGGAACAGTGAGGAAATCCAGCAGCAGATCTGGATCCCATCTGTATTTATTGGGAGAGAAGCTCCGAGTACCTGCGTGCCCTCTTTGTCTACGAAAAGGGGCTCGGGTGCTTCTGGTTCCAGACAATACCTTCCCTTGGGCTATTACCTCATCCCTTTCACAGGGATTGTGGACTGCTGGTTTTGGCCATGGGAGCAGTAATGATAGTTCGTTGTATCCAGCACCGGAAACGGCTCCAGCGGAATCGACTTACCAAAGAGCAACTGAAACAGATTCCTACACATGACTATCAGAAGGGAGACCAGTATGATGTCTGTGCCATCTGCCTGGATGAATATGAAGATGGAGACAAGCTGCGGGTACTCCCTGTGCTCATGCCTACCACAGCCGCTGCGTGGACCCCTGGCTGACTCAGACCCGGAAGACCTGCCCCATTTGCAAGCAGCCTGTTCATCGTGGTCCTGGGGACGAAGAGCAAGAGGAAGAAGCTCAGGGGCAAGAGGAGGGTGAAGAAGGGGAGCCAAGGGACCACCCTGCTTCCGAAAGGACCCCACTTTTGGTTCTAGCCCCACTCTTCCCACTTCATTTGGTTCCCTAGCCCCAGCTCCCCTTGTTTTTTCCTGGGCCTTCAACAGACCCCCACCCTCTCCTCCCTCTTCCCCCATCATCCTGGTCTAATAACCCTCTACACGTACACTTCTGGTGACCTATTTGCACAGACCGTCTTCTTCCCTCCAGTCTTCTAAGTTGAGGGATAGGGGACATTCCATCCTAAGCTGCTCCCTTACCCACACCTATCCTTTTGAGGGCATTGGGTGGGGCTGGGCAAGCAAAGGACTGGGTCTTCACTTCTTGGGCTAATAAAATTGTTTTTTGTGGAC + FJ-KJJKKKJKK)KKKKKKJKGKKJKCKEKKKKKHKKKKKJK@K8KKKKKKKJKKKCKKKKFKKK*KGDJKJKKK6KKKKKJ9KKKKKKKKK5KKK9KKDKKKKJKKIHKK>KKDKKKK-KKKKKK(KKKKKKKKKKK,IHKJKIKK;KKK7KKK3KKKKKKDKK,@=KKK@J-IKJKKGKKKEKKKGKKKJKKJKKKKKK1KKKKKK5KKKKJKBK@DKBKKKHKKFKCKBKKJHKKKKKKKKKJKFKJ(KKDDK9IKK*KKK9KJK4KK9KKKKKHIKK7KKCKJK6KKIIKK(KKKKJ5KEK8KJ*KKKI9KK@KHKKDKKIKK'KKJJ?KKK8KKJKKKGBKIK?KKKGKKDKEKDKIKKKKKKKKFKKJKKKKJKAKK@KKKFK/KKJBKKIKK0KKKJCJ@KKKKKK@KJKKKKKFKJK9KKJ;K>KKKKDKDK=KJIKKKD+KKK8KGKJKKCKKKKKKKHJKJKJKKKKKKKKIKIKJKKJGKKKKKKKKHDKKKKKKKKBKKKKHK&JIJKJKKJ,KKKJKKKKIJJKKKKKK=KEC;KKJJDKCKKKKGGIKK,GBKKEKHKFIKKKGJKKKKJJKFKKKJJFIKADGGKKKKKJK@IG?BIKKHKIKJKKKKKJKKJI2HFKKHE6FG9KIKKJKKKKJKHJKFBKJIKJKGJ1KG/IKJ>?KBHKIJJJFKK+KJ3JAKFK3JHI3KFKICKJKJBKIJHKDGFI:C@D8KDGIKHHKH,KKJIJJGKJJIJGKJJFKJKJ=KEGEIJ1HKJIAKIHKKJAFKIE/K>HK.FIKJAHKCK4JKJEKG3ICJKKFKKKK;KKIKH/KKGIIAKKK)H3JIJKJ(KKKKEIKIK=IGGDGIKJ?KK:KHK0KKKKK*IKKIKKG&FKHEKI3KKKKKFJG+EKGKGJKDJJGJF)HIGGD+8-I(KA7GIFJJK(KKKKKKCJJFJKIJHFKIDIJKJJ0KGI6KKKJJBJJG1IJJG?KC7J/KKJGJGJCGKKKKJ&IIF9EI*JK6%JKKE@*JII8KIJBF@GJEJK@KKG@I=HJIJEEE&@G2CIGG@FCBHDHIHCCKEHDFJJJKI1IFGGJJIEJ:4?@BE6GIIJHJDKD?@JF?JH?F@IIIKJFHHFKKIJFHHKEBHIGE4=FFH@CEG@FEIGF=;EIAF=CFD:DC+HFEFCDEJ>?A@HJFICDIBD0GF@HHHEDFGGCC@HBE?HDI:A@I;@D@>9HGHHHFFBD&DCBDH/GE:D38;FGBIHGCGHIH@FH8B>GCFB7>AADFGHI'ACBCB<-D?F8@JIFHIFEFI7GGICC@FIE??EJIGCCEE3DFEJBBEE?3B2FGDEAE*DGBIJFECCG@IHIIIJEI9A(BGDCEG@EBDH6IGC9F?C(BDGGGGHE9HGFFI=;>HGIIG?FHAHF8CAFEAF@B@DADIHHG@HH?I?BCC@@HCDE?;EH@I>FF8FHDCD/FGDFFJIHIFHC5@F=HE>IHIIECE=6FGFH3DCD<I7CE6HEDIFFDHHDGH>C?=DED7CDAF5GHGCJHBG;?BEAI5FHE4G9GIEH=CFFHGB@JJHG?>GFGFGI;D@HHCFE7:?<:B>CA>IA=:FIBBG=F?@EBEHBFCID?DDBI4AD?EHFHGFD?&@FFF@EF?D@IIFCF5IIGGCAFIIHFE@;E=JI>AEGCD.?C@AGFDHGEAGDAGF4DCHF;IIJC5BEEGGH=DGHG>8?@?D9DEIDBHFFH@H>G9BIIHA9EFG:?6E?E=FAHFG.:=GEA@C=FDGIFIC>AGGH3?GEGDHJFHH@FE@CDED::EJJ@>@G:CE?HFGGC=EAGIH?AEAGBHGEIFFI>CFHAIIJE)>DJCIE@7IHHD:=DC:D?AGHFIFEICF5B=HFJB7=IGBIH7BCIE@H?=FBD9FG>EHIFHJIGD?BC9HCGHGIGEDDH>D?CGIDHFI:IHBG=IIH*FFIF6GDHJIC6CHHB1CDDH>F4<@BGC:BC?6FEEFA;>FIF@B3DBA:D@BEBEBC@C<>A?7:E:E>DA6DGCF9ED@B=EE>FGCE@F9EEDDDHB=H>G@@BD3AICEBC1EGDA@F10FIDFE>H-HHA<5I3EGBD8FDIFAIIG>>HJIIG1HHB7CGG?A<46;DH@HFF=CG@$EECFEFFE@FHJEG>C>HHDJ@HG?B9ECG1AGD38?GEA@CD7GBHH4F:GHICBAEB?GH99I@HCDD>:CAFFFCG@AGJIB:GGHF?GHCIE9=CE:E6>EHID6GDDGJEHJ9BB9/BE@=@FBIBHH>9FHCGEB3>=HIFIAFFDII5GFHAI7HE8F?FH5HIHFEHED>G6,ACBBE?GCDG<>C:?GEID&ADDBHCFFCEG>H;BGDH;HGHI&BEG<:JICGJE@FC;F@D>IICGB:?H7HHF?IHFCD8G7HGA=B=GHJB0F5B:GHJ?BA9IDI@9>BEDE>BG/DB>0FCE:@CHGCFI6GFC@>E>E@?CDADEF?HAEI,GHFHGHFFIFHGFAHG9GG9GF<:AG@BCIFH5JFCIDDIH6EA/DG=HEF7F>>CIEF?A?C6#7-253;:=26/6>99747<5:-37><6935664:53:<194%2<1:3403)4'97854-69;/:;2=;2;:;-<788=4@@@;:>@F@7>3;7>7;%=?:<<7BB=)7+D@@ABB+<:1+#=@A8AA>;=A?B+;8289:%6<=);:@;;9@5;9%=5?:BD;8+--,,7?>.3;9*5;47B;%/20-64<79347<@1B;B45??B9:59?<#:@A@99;A4:-8..0=;=8,7459;/92::C9@/9<3.975A;*320=BB<7B<<>?5DA><=46=15>?7<8@8D?;80$.667646>7:3533236*==<<@C?>/37;=C>9?582@&/86.6=99(A;@=043:?39;;A?+78>C95=5?3+20?>.348;=B)77<976.$.&07>76A?4190;85:AAB90;&9:.821<59<47/-836825-6$244&589?67;;867=@9./.1481%'21#-/*(29<=7E72>727<<@238C?389(8EG>5H:15==B/>A<97>A)7$44-A5B<5-:09:F;A74;<7;129142(16BC;6>;BAC<<3;8==C@GAD?@@0=-;C<646;.0?66@>@6=0&?DH5=@=<>JFIHC6HIA9A7A>@GC@DA*@??DGB?HJD@FEFD:H6E:A@DG>EBEJABFBDBIH)C>BHFD3>JIIG;;E;3?GD;HIIEH9=?=>GG4&@@>BDKHC@775F-E%GFC4>6AEDG@G88ECBB8DB:B=CJ;4KBII3K,ACAB9IJ1@*BDD@KGJIH??EJAFEGFJ7DEA;9:B@BE2CEKK@F;3,CA@CD@?FA2C?94B2<8GB>HFD?BHJE1JF@8I@7JHK>@6BC<>C>GIH7?9=B+JEI6D4:CGCI1?DB?G;E@FBG:A4@?92DG9?7=:-?;C?=E=9::59A;A5<@@AC;9HI'EBBG>>E9F>B=FJHGJCA/B7?@HJ=FFGA2D?7E8H?@C92@B59><;B;<@7.A55F<=:@GEAD88@:6/<<>7G:F@F>:DDF??6>?B>:D?A7?6F;4A>B8=$79;8;-;?=*4.4;C>>?BEDD.BECAA9D?9;*A=@9AD94-=A$D+.=E8;B488A:(=25-;536?94A1IC>>4/;?>3'7-9,<<<;>4::=55:>3?A6959>6=8>@9>1@8A>@>@A?;?0>B=76)7>797065;8==5191407<5(629=D9=79+2>>731-4262704;7:%35<<3/4+16.44)950/246:92+=@>/42$31<8?:>808;@;:66:45<=:3<>14=?A?@>3836?5=846=87?997A=3@B9D?D?B:?CA?8:AE@5@:*<:.56;5>5@?:?<@C>BBA?:9?-0:>+9@:C@5BFA@8B?<=0,<1(;<=:A:@29%8?= @rCer/1359/1179_57_CCS TTTCAGTTGAAAAGACAATATGAAAATTGGTTTTTGTATGACTTTGAATAGTTTGTATTATGTGAAGTTATAATCTTTTCTGAACAGATGCTATAGACTCTTTATAATGTTTAATTCACCTATCACACTCTGTTAAAAACACATATGAATCATCAATAAAAACTCAATTATACCTGCTAAAGCAGGAGAATCCAAAGTAAATCCTGGAACCTAAACACTACCATCTACTCATTACTTAGACTCTGTATTAGTCTGAGAGAAGATGGCACTGGTTGTATTTAGCAAGACAGTTAGCATGAGCTATTCCTGTATAGTCAGGATATGAAACAGGTACAGTCATTCTTGAGTACTTGGTATATTCTATAGGCAGCTGGAGAGATCTGTGTGACACAAGATGCTTTTGTATCAGGTTCCCATGAATCTTTTGCGTCTTGTTTGTGTAACATGGAACAAATAACTTCTTTGCCACCACTTTGCCTAGATAACTGTGTGTGTGTGCCAGTTGAACTCTGACACCACATTTTCTTCTATGCAATCATGCCTTGTCTGATAATCTTGCATTGCTTGCTCTAAGCTTTAGTGGTCCTGTTGCACACTGGCCTTTCTGTGCTGTTTTCAATTTGCCTAATAATAGCAGTTACCCTTATTGTAATTTATGTAACTTTAAACAGGATCACACGTACCCCCTGCCTGCCTTATTTGCTTACTGAGCACAGACAGAGGCAATATACAACTCTGGGTTCACACACAAGCTGAGATGAGAAGAGGAATGAGCCATATATGTGGAAAATCATAGTTTGTAGGTATAATATAATATAGTGCTTTTCTCCCTCAAAGTATTTTTTAGTCTTGAATCTATTTATCTTCATTATATATCCCTGTGAAGTAGGTGGGACAAGTATGAGGGAAGAGGGGTGCTGAATTTTTAGGCCAAAGACTGATATTAATACAAATCACTCACTAACTGTAGAGCCTTGGGCAATATCAGTGAACTGCTCTAAGATTTACTGTCTTCATCTGTTTAATGAGTAGAATATCCGTGATGCCTACCTCACAGGGTTGTGTGAGGGTCAAATGAGAATGTATGTGAAAGATTTGTAAATGGTAAAGCACTATATTCTT + &##$$#($%$#$%((('$##%#()(%&#%""''%#%$#"$#'%&$&(%('()##'$"$$"#$$"#"%$##$'%((((($%'))())(((((&%$""!#$%&($$#%'('('%%&%%('))'%%$()(((&#')'((('"'((%#%##'$$')'()()))))&&$(%%"!$##!#!"$$%%#''(%$($('&#$))&%((&#&'#"$##"$##&(%$%$"!#$%&%$"$(&%)&$#(#""""##%##%'$''&#&$&#$#&#&'()()((()'($$$#()$#"#"###"$$%$'&$%'%'(('%&$%##$&##$$#"()(%&%#$%""%&%%'##&%$&')(%'"#"!!!!!!!"%$%%($""%'$%%&%((()(&()')(%(%&%(((&%&%$())((('($()($(''#(%()&$((($&'&'($&#")+,'+,#$!$**$%%),.---,'(%+)+,,(,-.--.+-.+$&+,'+$$&++*,.+,+)%&'#(#$&(+,(&*+$+-)-,---+,(.)(*,**,'#)+),('%,.,*+)&(,$+&+,((,+(+'%),)---.+--.,--,--.,,&'+'('&(#*-)$&,),(----,,$(%''#++$$$'%*,,+$)(%*,%()'*-,&-((+)(),,&*++(-(*%#(',)),',*--.,)(,(-'%%$&&&'+)+(#**)),,(%'+*),'(('%(++$*(-,,,(*-*,-,)$*-(,(,)*)(,'+,)*),--)+'%-,-')*-+*-,+(&-*#$++--(($&)((,--,())&)%&&#$#*'$+-'&,+-(,'$$-,&1/(*.(**"(&$+&+*11001-+*/-*+'--+.-1,-*-0/%&&1-/-%12.0+%.,.%).-++00((,'''**12001111.1.10+*)0&.,+.1-,0--11(-*.0,)+&&.0,10,/0/,%121000-'-0-,/,-/2*2/.0121))0---00,/0,00.&--'.-),-1/-//%,111/100-*%-1110-/(.(*1*0.10$*/(+/2%30/-%0&20),,&*/2./3655-/5/162-/343.010,0+651$12-/3,')06042.4162162%1/,*,,+04660/046-,2*-/-)14/+*)()/'0/) @rCer/1360/25_1779_CCS ATGGGGGACCCGGACTCCGCCATGTTGGGTCTTGTGGGTCGTGTGGCCACTGCTTCGGCCTCCGGGGCCTTGCGGGGACTCACTCCTTCAGCGTCGCTACCCCCAGCTCAACTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCGGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACGGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTTATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTGCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTGGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCCGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCTGGTATATGGTCAAATGAATGAACCACCTGGTGCTCGTGCCCGGGTAGCTCTTACTGGACTGACTGTGGCTGAATACTTCAGAGACCAAGAAGGTCAAGATGTACTGCTATTTATTGATAATATCTTTCGCTTCACCCAGGCTGGTTCAGAGGTGTCTGCATTATTGGGCAGAATCCCTTCTGCCGTGGGCTATCAGCCTACCCTCGCCACTGACATGGGTACTATGCAGGAAAGAATTACCACTACCAAGAAGGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTTGACTGACCCTGCTCCTGCTACTACGTTTGCCCATTTGGATGCTACCACTGTACTGTCACGTGCCATTGCTGAGCTGGGCATCTATCCAGCTGTGGATCCTCTAGACTCCACCTCTCGCATCATGGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAAATCCTGCAGGACTACAAATCCCTCCAGGATATCATTGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACTGTGTCCCGTGCACGGAAAATACAGCGTTTTTTGTCTCAGCCATTCCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGACCATCAAAGGATTCCAGCAGATTTTGGCAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATGCGTCGTGAGGGGTCCTTGTCCTCTGTACTGTCCCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTATCTGTGTTGGCTGCACAAGAGCCTTGATTGAAGATATATTCTGTCTGAACGGTATTTAAGGTTTCCAATAAAATGTACACCCCT + KK6KKKKKKKKKKKKKKKKKKKKKKKIKK>KJKKBKJKKKKKKKKKKKKKKKKKKKIKJKKKK6KKKKKHKJKGKKKKKKKJKKKKHKKIKKK?KKKK=HKKKKHJKKKCKKKKIKKEFBKJKKCKKKIEKKKKKKKJKCKKKKKKKKIKK8KKGKKKKKKKKKKK>KKKJKKGKKKKKKKKEKKKJJKKKKKKKKAKIFKDKKKKKKKKKJKKKJKKKKFKKKKHKKKIKKJKKKKKJKKIK5KKKKKKF;KKJKKKKKKKKHKKKKKJKKKKBKKKKKHKKKKKJKKKKJHKJGK8JKKK@KAKK6KJKIKKKKKK5KKKFKJKJKKKKKJJKKKKKKKKKKIKKKFJ>KH:JFFKJICKKK0JJKKJ;KJKBJJKKKKJK?KKHKKKEJKKKJJKKKKKKKKKKKKKKKKKKKKKKKKKJKGKKKJDKJJKKKKK6KKKKK;KKKHK:KKKKCGKKK>KKKKKKKKKCJBKKKKKKKHKKKKJKHKKKKKKKKKKKIKKKKK:KKCKKKJKKKJKKKKK=KKHKKKKKKKKKKGKKKEGGKKKKKKKKJKKKKKIKKKKKK9KKKIKKKKK8KKKKKKKHKJKKKKKJKFKJKKKKKCKKKKKKKKKKBGKKKKJKKJKKKAKKJKKKIKKEK2KKKJKKKHJKIKKKKKKKKKKKJIKKKKKEKKK>KJKKKKKKKKGKKKKAKIKHKFIKKKKDKKKFKKK>JKGKKIKJJEJ=KKKJBKKJ8JKKKKIHJKKKKKKJKKHKKHKKFKKKHKGKKKJ?KKKKKKKKKKIKJKKKKKKKJKKKKJIKJKHKKFKHKFGJKKEIK;CKKKJKKJKKKKKKKJJKJIIK2KKKKKCKKKFKKJKKKKEK>KKIKKKKKKKKKKKKKKIKKAJJJKK=KKJKKJKKKKJKHKKKKJKJHKKKHKIKKKKKJIKKKKKKIKKIFHKKJKKKKJKKKK-KJKGFHKEFK;JJABEAKKKKJKKKJKKFJJFEKKKKKKIKKJKKKKKKGG9KFKKKHKKEKCHKKJIKIKKKKKJDKJK4KJIKKKHHJJFKFJJFKKKKJKKJKKIGHK.KKKKKKKKKJ6KKI9JKKJKKKJKKKKKJKKJKKKKKKJKKJKK@KKKKFJKIGKK?JGKG?HKKJKJGJKKFKKKJJJKKKKKJIJKKKHKKIKJKKKKKKKKKIKK?KKKKKIFKKKKKJKKKGKKHKKKFKKKJKKJKKKIHKKHJKHKJJKKKFKKKKKJKJKKJKK=KKKKKKKK:KIGKJKK?KKHKKKKKKKKKKKKKJFIKGKKKK9KGJKJ9KKKKKKKJEKKKKKKFKHKGJKJKKKKKKKKKKIKKJKKKKJKJKKJ?KKKHKJE?EJ>;=9;5:8;;44%02<47:7&=;89=7;(6*:6%5<-00%684>99695*94>;1<-7926=;;8==75=<<=)88?0<63/887;>76390/)826<49;4<:*;;40-3%%25+79137,*8:=:==?9;242(0=:=:;<:48?;988975+:5<29?578,712;>54=9:;999;9;5/8=37=96/25267&:72:79>9=>+?6<>=,7:99986036550>;0::48;:;9>6=8>7;;618.69<>>29:0;?5/;%:4::89:;:;(9=8996>>::/21/:;+385'779/69$287499)67:9:80,149399251997244(7/6:78.:55;6::::88;;5355,78+7-8205699-4480&-3&115/395(089-996308/84605:3939560+44620:/+266+4126(32469648,-56/.11-7,659655:1-95.;8570'4-99:4:907665445225011799(8262'04/3.6*5587398059233456278787::442015/,2/74-14746506657907195695/&566-271892982-8::6987;6./5-03:588/%/3/;7792%21441,'426013361.)+3,343596&:.39,05*7;568::57;;/&.1934+-9776#62.6.+:78767/6;6,14.47978(9615/59353)3/898,2.222'--'21/3)0:4-9.2/4*()54525052:47*634.+/46/439339$-.468--8965430*28936'0884:207632459(7864'76737954689:/6452,'3:4:1;;6#8566)488495640565/67+2912'/.98.98.9:94:72.14&/569:2927,9(98433949;;668349605245659,826037929853%2+.)7-:3:7:66287178+2'66,426&481667)759.%3965,52,55:658*8:38-894625:05679:-8759:71,1&16:75.3:88289,'-7377412'.::5-:58813*56::6357:+034+475)1542635776651*3/55:4/73858*827553&896/7307-8956-+5+3&08,77(/&17/54/&.*'40688//931.73%59:145&)45'687-8+42899/95'%4,6/4.-46:324(2/1)150)36.8512&28.36:511/(-86:4889355357736795.2(38946)98:698878918;960&9*/892769:38'167:79619./-1355%1678-,1/8)708967,85)29)503+(+$#/97'//8(8512-&+.08:218114%,74&,47:.403)644,,8'7677:-17563825:76:662836'/7/63:69*3,/'.-/68*/,&$/'85;;/5-.895*2,08(9276*145)48111%4436;66/%7;&11153*(/638.21%37-44,5;;855659:2.223(735(79.5/6(54-7/355'4)474663.432.5*8.08:45:917*9557/556577.838.:5865.140&0+798/269.;79263:658./379537322.56+4862/(612247*3-56/-112'3/11('.(.'2.560,4-,455,1,/.&)2-.--2%,/3,43.52/522*#-2342.*5/.)01*40241.,-$5/42-5524251414555*.13-0)411/+00).-6355003-4/4,*134 @rCer/1366/2393_56_CCS ATGGGCGGGGACAGTGTGCCTGTCCATCTTAGAGGAGGACAAGGACTGGAGGCCAGCCATCACAATCAAACAGATCTATTAGGAATACAGGAACTTCTAAATGAACCAAATATCCAAGATCCAGCTCAAGCAGAGGCCTACACGATTTACTGCCAAAACAGAGTGGAGTACGAGAAAAGTCCGAGCACAAGCCAAGAAGTTTGCGCCCTCATAAGCAGCGACCTTGTGGCATCGTCAAAAGGAAGGATTGGTTTGGCAAGAACTTGTTTACAACATTTTTGCGAATCTAAAGTTGCTCCGTACAATGGCGAGTCACCTGGGGGGTTGGGCGGGCGCCATCTTCCATTGCCGCCGCGGGTGCGCGGTCTCAATTCGCTGAATTGCCCGTTTCCATACAGGGTCTCTTCCTTCGGTCTTTTGTATTTTTGATTGTTATGTAAAACTCGCTTTTATTTTAATATTGATGTCAGTATTTCAACTGCTGTAAAATTATAAACTTTTATACTTGGGTAAGTCCCGCAGCAGCGAGTCTCGCTCCGGGATGCAGGCATGCTTCTCACCGTGCAGAGCTGCACTTGCCCCGGCTGGCTGTATGGAAACGCACCCTCCCTCTGCGCTCCTCTCTAGAACCTGGGCTGTGCTGCTTTTGAGCCTCAGACCCAGGTCAGCATCTCGGTTCTGCGCCACTTCCTTTGTGTTTATATGGCGTTTTGTCTGTGTTGCTGTTTAGAGTAAATAAACTGTTTATATAAAGGTTTTGGTTGCATTATTATTGAAAGTGTGAGGAGGCGGCCTCCGAGTGTCCCGCCCTCCCACCTGACTGCAGCCCCACCGCGGGCCAGGACCAGGCTCTCCCATCTGCTTCGGATGTGCCCAGGCCGTGTGGCTCCGTCTTGCCCTGGATCTTTGTCAACAGGGCTGTGTACAAAGTGCTGCTGAGATTTCTGTGCTCCCGGGATCTTCGGGCTATAGAGCGCTGGGCAGCTAAGATCTGCATAGGTCGGGATTGGCGTTGAGACCCTGGCAAGTGTGCACCGGTGCCAGCTGTCTAGAGGGCCACAGGGCCAGGTCCAGACCAGGGCTGAGGCTGTGTGAGGACTCCTATCCGGCAGCCTGCTGGCGGGGGTGCCCTCAGTGGCCGGGTCACAGGGATGGAGCCGTGCCGTGCACAGGGTGCCACTCGGGTGTCTGTGTCTCACGTCCTCCGGAGGCAGCCTTGCTACCACCCCTGGCAAACACGGGGTGCTTTCTCCAGGAGAGCCCACAGCCATGGCCCCTCCGGGGAGCGCCAGGTGAGGGCCCTGGGCGGCCTGTGTCTGGAATTCTTCGTCCTGAGGTTACCTGAGCATGGCCTCTCCGGGGAGGCTGTGCCACTCAGAAGCCGCCCTGATGCTGAGCCTCTGCAAAGGCTGGGCCGGCCAGGCCTCTTGGGCTGCCTGAGCTGTGGCTGAACCGCTGTTTAAGAGTGGCCTGGCTGGGAAGTTGGATGCCAGTCACTCCCAGCAGGAAGGTGCAGTGGACAGAGATGGGAAGCCCTGGGGGACACAGCCCGACGCTTCCAGCCCTCCAGCCTCCGACCCACCACCCAGTCTCCGCATCCTAGTGAGCTGGGCCCTCCTCAGTCTCGTTTCAAGCCCTGGGGCTGGAGCTGGCCCTGCTGCCCTGGTGCGCCCCGGCAGCTGGAGCTGGGTCCCGTGGCCCAAGTGCAGGGTTCCAAGGGGCGGGGCAGGTGCTCCCAAAGGAGCCAAGAATGCAGGGAGGGCGGCTGCTGTGGCTGGGAATCGAAGTTAGAGGTGACTTCCGAAGGCCCCCCGAGCCGGCAGTTGCCCCCCGCCCCACCGGCAGCTCTGCAGTGCCAGTGCCTTGTTCGCTTTCCTGGTTACGTGCCCTGCAGTCACTGAGCTCTCGGTCTGACGCGTGTGGTTTGTTTATAATGCAGGGGGCCTTACCTGGGGAATTCAGCTGGTTTGAATATTTGTAGCTCGCTCCCAGAATGTCTTATTTTGTAACGACTGAACTACATTTAGTAATAGTTACACATGTATATGGTTAATATATATGGAAATTCAGTATATTTTGTAGTTAACGTATTCTAAAGTAACGGATGTTCTAGCCAATCGTAGTGACTTCAGCTAATGAAATGTTCCTTTTGTGGTACCACAATCCTCGGCCTAACGAAGGACGTGAAACCTTGTAACAGGAGAGCTCTGAAACGCGGTCACCTTTGTTTAGCGGAAGGGAGAGCGGGTTCCCGGCATGTGGTGCCTCGGAATTAATAAAGAATTGTGGGCGATGGGTTTACCACTGTATCTAAGAATCCACCAATTAAAGCATTTG + 847604301%-*%&230--,5735'2/.9/6105),2/45616.+4/1,46061))60152356324641253)2'266434/5-50-22/5+21&,.//--,-%'+()$.,.003355+6/11241434/14*5,64/,1.*,-12#/-001'461.53202/63%.1+3-+///,(#&$%-01-)31,26553655022(/55/12344550+550643-$/,0%3-4.010316652644*4'22$1054+41265,5+063555+3462516646+1644+54656306351+644.03515615.*1--11,.534661513/205412064.550+6,/4044342,/0/*,--.*.+%''((3,31,1515632.566/46606252+1356.445364632*41(01654+5531050)353/45,0+.1143*203/101/**/24(+00(+&..114402-433'43.01,-1/.020%1-5553.5634+*02365664,,(2132*10,56001.401*215405163/4/32.0.,/14-1+410*4/302656434.31)*.(($&.'/.*/0*15140*3-650/503665/54/4003*4526120/./.23342426/0/1155120555%--*5332-0.14&.2010*364424662625341-30125.6246115/33$/5146552344&464353441//5554-*./5436.2662.)4661234566165563/4252./31&-2+13*264054625262.425600-+4023420163+.10&(1.(//.246263430013&34*4555*2('1/542.251*+%-*+.23-2+604505635153*44(3(1/,//(.34.2-.0-532%16205534.0555./,,-(0141/4/302-3)/.+2/*315354.//+540545(54)02164325.4+01.)225625665632306512643222205.+014+154226462654.3/3342160*3132526.-+555*56561-.+5216606055145.6416211,*//5*402'31#,514143.46664-.1455450-3$01550562+63+6163/1.42%465620$203313416565/0.55553001..()10132/23+4/1+1$4422%12/525364-5242000&,4+-)16/014504)56532'2155+34-454,.0/340*04001)12515245..521*/.*41.146.642-45/132)315.+,1.,,$./4'22&223*54/4+'334201654-4.15155++,120626146414.04-3.)5*31501524(01,242155)05562/1$340225*.1)1/154*(2$23*4415)*'4145.5/6/6/5202*456023(31142524.1551225545**&366564*63253/3,65665315601.,64616226510451#-32*/55./*3.624.--,4510322354564030.66..3504)/./10,-.-,10,//)1,-012-121.0.'02+)*.+&,.&+0-)*#$',.-1/,,0-/,+,10*-10-%-/*/2-,0.)0,-1000*/0'/0/,,010+),21.0,/0-2.*01000-((,/*011,+.0%2.0,'-+2000-/02.021.&(/+.1,20.,-111/(.&(&1-,*.%,01-&&),*,((..1+11+0**(0*1,01,*01022/.+/*.1/+)*,/101-1/1/*2.1211-,1),-12,1/-+1+21/21.+,+,,.#/0-./01/,+(#-1.-1.+,/-.%*+(-+(.1-01/00-/*01,-/.12,0-0.&01/.0'0++1-0),.*,01-(,-*-+0,-0-/.-,1101-%+..-,+-0.-/'2-12+,01*012.10/,*00/&202./-&//..'2.0++,12/.(/,)')+++/.*1.011110-12201,2,,/+,*'*010)/,211*&/.01,0011011-01120+(/0+00-,.,,,*1/,1,+,*',,/,+.-.&00*00..-0,00001(+/10606+00*+0+./01'146256405//$+015604/565-52134561--4640/.56354.5+/*412'515/202&464&08179/,6+09475979554653/4#;8;8:8:523//.667:862783-687:49792256*:;;9689728186-0/569993;559(80535501.,644316565/(,%,.2%11(6045432436566132&22--/2341/**00/5-56.11*2)606613613/)/ @rCer/1367/25_1541_CCS ATGGGGGGCTCCGTGGGCCGAAGGGGGGGTACGGAGGTGGCAGCGGTGGGAGGAGGCGGCGTAGAAGGCCGAGGAGCTCGAGCCCGGACCAATCCCCGCGTTCTGGGCCGCGACCCTGACCCTGCAGCGCACCGGGAAGCGAAACCGGCCGGATGGGCCGCTGAGCCCGAATCGGGCACTGTGTGGAGCCCCCTGGAGCTGAGATCAGGATGTTCCGCTTCATGAGGGATGTGGAGCCTGAGGATCCCATGTTCCTGATGGATCCATTTGCTATTCACCGTCAGCATATGAGCCGTATGTTGTCAGGTGGCTTTGGATATAGCCCCTTCCTCAGCATCACAGATGGCAACATGCCAGGGACCAGGCCTGCCAGCCGCAGGATGCAGCAGGCTGGAGCTGTCTCCCCCTTTGGGATGCTGGGAATGTCGGGTGGTTTCATGGACATGTTTGGGATGATGAATGACATGATTGGAAACATGGAACACATGACAGCTGGAGGCAATTGCCAGACCTTCTCATCTTCCACTGTCATCTCCTACTCCAATACGGGTGATGGTGCCCCAAGGTTTACCAAGAGACATCAGAGATGCGCTCGGCACCAGGCGGGATCCGGGAGACACGGAGGACTGTTCGGGATTCAGACAGTGGACTGGAGCAGATGTCCATCGGGCATCACATCCGGGACAGGGCCCACATCCTCCAGCGCTCCCGAAACCATCGCACGGGGGACCAGGAGGAGCGGCAGGACTATATCAACCTGGATGAGAGTGAGGCCGCAGCGTTTGACGACGAGTGGCGGCGGGAGACGTCCCGATTCCGGCAGCAGCGCCCCCTGGAGTTTCGGCGGCTTGAGTCCTCAGGGGCGGGGGGACGAAGGGCGGAGGGGCCTCCCCGCTTGGCCATCCAGGGACCTGAGGACTCCCCTTCCCGACAGTCCCGCCGCTATGACTGGTGAGGGCCCCGGGCCCTCAGCCTCTCTTGTACAAGCTGAGAGGCTGAGAAATCATCCCCTGAATAACTTTTTCCTCTCTGATTCCCATCCCCAATTTAATATTAAATTAACAGGCAAGCCGGCCCCCACCTCTCCCTGGGGGTCTCAGGGAGAACCTTTCCCTACTTTTTCCTTCTTTAATCCCCTTACCATGATGACTTCGCCTCTGCATCTACTAACTTGATTTTTCATTCTGCTGCTCCATCTTCAAACCCCCTCACCTTTCCCATTCTACTCCTGCCATGCATTGAAGGGTCTTTTGGGGTGAGCTCTGGGTTTAGGGGCCTCCTCCATCCCTCAGCTACCCTGGATCTTTGCCACCTCTTCCTCAGAGCCCCCACTGAGGGGCCGTAGCCCTGTCTAGGGCTGTGGAAGGAGCAGACTGGTTCCCAACTCTTTCTCCCTACTCCTGCCCACACACATCACCAGAATCTTCCCTAAACCCTTCCCTGCCTTTATTTTTTGATTTGTGCAACTTGTAACTAGGTGTTTATGGAATAAAGGAGAATAGAAAAAAGACCAAAT + JJ2KKKKKIDGJKK8KKGKKIK/KKKKKKJKKKKGEKG6KKKKHEKKIKKKJKEKKKHIEKKKJJKIKKKKKIKJKKJKKIKJKKGK@IKIKK6KKKKKKKKJK>KKKKKKK;BGKKHJKKKKKJKKKKKKKKIKKKKKKKAKK=K;JJKKKKK9KKIKJKKKJCKIHIEJCKKKKKJKKIKJKKJKKKKE2JKKKKKKKKKKIKKKJ=JKKDKKK:JF8KJJKKKKKJKKKKIKKKJJKKJHHKEKIKKKIKJIKJJKKIKKKIIKJKIKJGKIKKJGKKKJKKHKJJJKKKKKKKKEHKGKKKDKKJKKKKKKJKKKKKEKKIKKEKKKKKKKKKKKKKKIBKKIKAKBKKKK>HI>GKK2KKKKCKDKKKKKKHK/KKKKCKKKFK=HJJKKKIKKJHEIKGKFKKDHKKJKKEKFKKKK;JKKHKKKKKKJKKKJ.KFEKKI;KKKKKKKKKJKKIJKKKKHKKKJGKKKKKKKK@KKK'KKIIHKKKFKKKGJIG>KKKKJGKKK6KKKIKKIKKGKKKKKGJGGKKKKKHJKHKJKKJKKKKJJKKKKEKKIKKKKIKKKKKJKJJKIJKKKIKGJKKKKKKJKKKK=KKKCKJKBKKGHKK?KKJKHKKKK>KFKKCAKKKKKKJCKKKHIKJKKKJKKIKKKKFKJI3KKKKKKKKKIKKJKIJ1JKKK9806:;4>>=;09<4'$9<;%'.74:;3;<085:)<36%$3<=&+11-:9->0),#"*@07619<1-830@+7?*6A221164305'6-55920.='=.:5<@6=>A77?0=,@+>,54@.99(=><77>/$65045%9BA>A345:;(:3<*A?:%8)-@4338=+=<<9,/=77=@8=(?6>A?;4,6*?<%4+.*9678771.,43AB&(@)-<=5B,B?A:/45>-;)@82AA=(4;>8?<7A>C=:&A/>>:4=A@A-3.=<=<5--0/8=?657C:AA:69-3:;8>3<(?6@+9/297%-';99+<1@2<;7><9/<+0<=&A@07:?,3887@@@'=;@>7?64$-;962.%<49@7:A-74:'98:,2::6>>(*<)5A?/?:,0*;>,:%>A:'99'9(=?)@+5/:8@*44#2?6>@>86)=B,B28/>?=@>).,?@%+-@7094<(1>%*+1;>>&>::3;?.74/&"0463-,2;/B:33,@6-6?#)*;6601:29,>$12@C5.37:=$.2$2143/A62497:*4:,:BB0;>-3:8#368B?8%(+;B2<.?=78;?<39.7=B081:=(=?;>/+83%7=;*/9/7;>*&9,%(27:.2,<2&156*:>6:.61=;5*=-/5*;3&=036>C<.??=9&2:<<:==>.@>,+6<)<@;=B3AA830'426:@<>67:>75'676')18%957358>6@9:-;.+8<5%3=@)>28<2<2=6863:'=?@8@98A;<02;'+=,8:?/,>?6,/3>8A92>8@?*=4;@8<+:9B<>:8;->568><+;>&58976=B:<=849/?==75:A.?99.@;=5297?=04@09=419=::>4936<286*<$65<668)7=4=@4>B==;=<(71<$->A.3><.4:@>=C<><2/C=;60-73&>>8>>1>>06.<,,9>18=98.>2=.<>@A=;3@+>69887+*(;$:9676$/+5,5*5,,=3B37=:%3?=?'><=>4>%8<:.84?5,7>&@8@C4739767>?+;82AB-67;,19B2@8620:0?*9?2=$<+10>-6?,<%8(?135'5>/5755+=?/6139,><0A::3303+08+:$2569-9AC6@@365<72=B.4(;;92:3%9><*9<6@==<;*21586'/'4)3,26289639<>;???4:17<<-2(4.6.<7670;>,<<<:?0897.7&76235;(9*8.655<58=610566,189:)82:09:'36+::,0:88-<=075:029,010:27?1<3;,3/38.6*9;=7:7<;7&5/$5)&77738=3;7:1;>909=42;387<7?89>=;:)18:9&42:<=+=38>:;7::24=>6;8>:%/$7:-0280117:(/;*>227973/2/9)=:/-&<08/911=755<5166<'/7-<,01)'/:73<<9(6:64,)1-/2/7;(7;579>/88=1;68=853>848,6:<):;.7>2=;0505(997+96895389447885-+,=4&7*3<308047)34.*(%$.5,$6;745'8(=/<3,&2310),76>303929>==19<13.;87.18.46?7*'/96#07,'/035&/2(;+0:3)421496)246&7=5432172/81=>>.7>>-3%;:-;=<0<97-=>9347:7::'8;&4==71591>7=7096.(973:;67958-:65+79+:59.6:3:3841=:<=1'76945'7)7-5?;017<>5::09=-82-/6'+.7*9/7,9)(64:589;93:7,46=97;565:658?6)*)9&7;3$0264<<2;:>0:3$9;%4887<=292:;+$2=*.09.<78851=3/:(?=/+=40%(677$;>=68498%2362:2<2:6%%-667,7;8294-5852/%'2)514547&25692.(575;+70)(+693//%44.(%78=8793>/159878/,5:9.*,664)<;725& @rCer/1370/25_1562_CCS ATGGGGGGCATCGGATCCCCGGGCGTGGGAGGCGGCTGGGATGAGCTGGGAGGCGAAGAGGAGGATGGCGAGGACGCTGTCTCCGCGTTGGTGGTGGTTCATCCATGAGCTCGGATTTCCCACATTACAACTTCAGGATGCCTAATATTGGATTCCAGAATCTGCCTCTCAACATATATATTGTGGTTTTTGGTACTGCTATATTTGTCTTCATCCTTAGTTTACTCTTCTGTTGCTACTTGATTAGGCTAAGACATCAAGCACACAAAGAATTTTATGCCTACAAACAGGTTATATTAAAAGAGAAAGTAAAAGAATTGAATTTACATGAGCTCTGTGCAGTGTGCCTAGAAGACTTCAAGCCTCGAGATGAGTTGGGGATTTGCCCATGTAAGCACGCCTTCCACAGAAAGTGCCTTATTAAGTGGCTGGAGGTTCGTAAAGTATGTCCCTTGTGCAACATGCCAGTTCTACAGCTGGCCCAATTGCATAGTAAGCAGGACCGTGGACCCCCTCAGGGGCCCCTTCCTGGGGCAGAGAACATTGTATAGCTTACCACAAGGATCAGACTGTTGCTGGACACGACATCCGTGTGGAGCCAGGAGGAACACAAGCGGTGTCTGTATTGGCTGCTCTCTACCTAGGACACCAGCTGCCACTTCTTTTGCCTCATGAAGAACTCTTGGGCCAGCCAAGCTGGGAACCTGGGTGTCTGGGTCTTGTGACAACCAAAGCACTTTGACACTACCCCCTGCCGAGAGAAGAGGAGTGGATGAGCCTGCGGGTTTGCCTCAAGAAACTTCATGAGGGTCTCTTACTAACTCCATTACACTCTCTCTCCTGGAGTCTCATCTCCATGTCAAGCAGGAGGGTAAAGAAGGGAACTAAGAGCAGGTCTTTAAAGCCACACCCCACCTGCGGATGGATGGGTTTCTATATGGGCCATGCAGGCCTTTGTAGCAGCAAATCCTTCCAGCAGCCCTTGAGCCAAGTAAAACCAGCACAACCAGCCGCCAGTGGTCGGTGAGGCAGTGCCCACAAGGCTCATATTATATTCCTTTGATAAGGCCATCTTGGAACCCAAGGGCTTTGAGTAGCAGTGTCCCTCACCACCCATTTCCCCCTCAGGATTACAACACCTGCTATCAAATCATCTAAGCTGAAAACATTAGATGCACTTGGAAAGGCCTAGTCAGAAGCCATTTCCTCTTATCATTTCCCTCTCCTATGCACCAGTGAGGCCCATCCAGAGCCCCAGCAGGGGGTGGGCCCTGAGTCCACACTGTCCCTGAGTGATCCAGGAGGCTGCCCACATCCCCACATGTGCACTGTGGTTCCAGTGTAGCTGCTGTGGGCCCACTGCCACCGCCTCAGGAGGGAGCCACTGGGAACCCCTTGAGTGGCTCCAAAGAGCAGTGGCTTTTTTGAGAATGGCCCATACTACTGGCCAAGCTGGATGAAGGGGATGCCGACCCCTTGGCCTCTCCCACTCCTCCTTCCATCTCTTCCGTCTCTTGCCCTCTCTCTCTTTCTACTT + 9A.@ACCC@A>B4=4?6=<:559::94:;:9225@C=>>A?>>1:>>;?8:-@8?1=7BC=<=88@;AC>:;A3B>>A9;<=@@?A=>>@190853B7/88;6<5>62A>?6=AA3?8:><2;81>B>>?62;.=>@<9@@CB?>>+@?59:>2>)280A@:;==:<>98B8?0:;=<;CA@@AB2C?ACCA<@@?AC@49<455B7;18<8A=6A==?;B?CA>B;89?C>=>;3=<>?>;C9??AC?>A>?7B6>?@@ACC<-=<AA9=:2:+;:@@@:;BA=?C?;B7C;C6;=/;>34:?@769=B;B?=>6>5?A;A@29:B@?@>?<3:>BB2?B<@<;6@4937>?>?76;5>ACA8?78>BC4CCA9<:BA(=<;;>@=A:BAA:AA?;9=;?@C9:=<1<;B==A4=B>;>=>;6;@;?>A5;67A<@4<;189<$08=69>837;:9;8=61-37+1:<968>36=<2>:7@==A@A+>:8>@?:B:C>>A@?C3@9=B4?<>C8@@;4:>?+<57);6?5>?8>@==?7/626::82?9?8@?0>07@B;=;/=5<:=96<=@<3983BAB;4B:5%;1-(27+9<=<;:=>B@=3?>:7A59=9>=:7>?=<55<:@??40/:91+;6<37;0@=<=?A?:737:<=81B98>C@8A<;=>6=?B@9BA676;?6)21:=>ABA=8:3>B@@=?CC,A<7;2:0476>;C6:>;AAC>C:>3?>::<==A>?CB@6<<46+>;05;B::91-69<18?C:A2@>=CBCB/<68@->=2<=<0?4:86>2<7/87=22::A;4@7B7@B@592@436==@=<@>746;965?=@>?@?B>7<;800>;6;?335;<8C9?@0;77?<>=7@>?7ABC><<69>@6@:=BA?A<5==0BA;BBBA<9<>?A>@9B?93A<>=4ACC>@?9=>@8A;BB=9@6<=7>B6B;25<;;=?CAA@;>CC>?>AA8=5/B9?;A:9;:><>@2?C;A<.>A7>=BB7B:B;710:>;A:.>3,<=;:6<C>CAB?;=C<=AC6=:8=BB>=@=74;<@*8=>?1>5?86:?B>5=A?-879/@;79?=BB98A*=;8=3><=>67672;>::1>5; @rCer/1373/25_1733_CCS ATGGCTATCTCCCAGCGCCTGCCCCCAAGGTAAGAATCCTGGAGAGTCTCTACTTCACTCCATCCTGCTCGGAGTCAGGCCCCCCTGGAGAGCGCCTGGATCCCTGGGAATGTCTTCCTGGACTCAGGTCGTAAGACCCGCTCTGCTCATCGGCGCACCACACAGATCATCAACATCACCATGACAAGAAGCTAGATGTGGAAGAGCCAGACAGCGCCAACTCATCCTTCTATAGCACGCGGTCTGCTCCGGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTTTAGCTCGCTGAGTTCTCCGATTATGGCAACTCAGCCCTGCCAGCTTGCCCGGCTACCGCCCACCACTCGCAGTTCTGCTCGTCGCTCCCAGGCCGGGGTGTCCAGTGGCCCCCTCCAGAAGGAACAGCTTCTACATGGGCACTTGCCAGGATGAGCCTGAGCAGCTGGATGACTGGAACCGCATTGCAGAGCTGCAGCAGCGCAATCGAGTGTGCCCCCCACACCTGAAGACCTGCTATCCCTGGAGTCCAGGCCTTCCTGAGCCTGGCACCATCACAGATGAGGAGATGAAAACTGGAGATCCCCAGGAGACCCTGCGCCGAGCCAGCATGCAGCCAATCCAGATAGCCGAGGGCACTGGCATCACCACCCGCAGCAGCGCAAACGGGTCTCCTTAAGCCCCACCAGGGCCCTGGAACTCCTGAGTCTAAGAAGGCACCAGCTGTTTCCCACGCCCATGACTCCCCGAGACCGACATGAAGGCGCAAACAGAGCGCTTACTGAGCCCAGAAAAAGCGGCTCCAGCTTCAACTAAACAGGCTGACCGGCGCCAGTCGATGGCCTTCAGCATCCTCAACACACCCAAGAAGCTGGGGAACAGCCTTCTGCGGCGGGGAGCCTCAAAGAAGGCCTGTCCAAGGCTTCCCCAACACTCGCAGTGGAACCCGCCGTTCTCCACGCATCGCCACCACTACAGCCAGCGCCGCCACTGCTGCTGCCATTGCTGCCACCACTGCCACCCCTCGAGCCAAGGGCAAGGCAAGCACTAAAGGGCCAGTACCCGTGAGTGGCCCCACCTGTGTCGCTGATGCTGACCTCACCTGGTCCTCCTTCTACTGTCCCTCTCAGTGCCTTCTCTCAGCTCCCAGGCCAACAGTAGCCAAACCCTAGAGACAGTGATGCCTGCCCGCACCCTGACCTGGTCCCTGGACCTTCACTGGCAACTTCTCAGAGCTGGCCCAGAAGGCCTGGAGCATGGCAGTGTGGCGCTCTCCCTACCTTGCCTCCTTTTTTCTTAAAGCAAAGTCACTTCTCCATCACACCAGATTTGAGGCTGGTTTTGATGGCTGGGTCTTGGCCTGGCCAGTCTTCCTCTTAGCTCTGGATCTAAAGGGACATAAGAGGAGTAGGCCCTGTTCCTGCTCTCCTGGAGGCTGGGCCTAGCAGGGGCCCTCACTCTTGAAGTCCAGGACTGGGTCTGACCTGGTGGGAGCACCTGCCAGAGGATGCTCTTTCCAGGACGATGGGCCTGTGTCTCAGGAGTGGGGTTGGGGGACAGCCTTCAGCGGCAGCTCACACCTACCTTCCCAGACTTGCACTGGGGTGGGATTTGGAGTGATGGGAAGGTTTTTAAGGGCCGGGATGGATCTTTTCTAAATGTTATTACTTGTAAATAAAGTCTATTTTTCTCCCG + 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@rCer/1374/0_1286_CCS TTACTGTGAACACTAATGTTCCTGCTTTTTTCAGTCACCTGAAAAAATGGATGCTCAAGCATTTCTTAACAGATTCTTCTGAAGACACAATTGGGAAACATCGGGCCCCAAAATGAGTTCCTGATGCTAACTGAGGTGAAAGGAAAGCAAAAGTCAGCTTCCAGGGAATTCACTTAACAAGCCTGTTCAGTATGGAAGACATTATTTATCTGCCTTTAACTCCCCCCAAAGGACTGTTCCAACTGCATAAAGTGTCTTCTATCTACGTAACTAACTGGTAGATGGAGCATCTTGATCACTATATGACAACCCTGGCTGTCATTTTTAGTTGCCTATCTGCAGTGATTTGAGCAGCCCTATTTTTACCAAACATACCTGAATTTGTTCTTGGGCTCCCACTCTCTTCCTAGAAAAGGGCTAACTTCCTACTAAGGTCTGAAGAGTGTTCAAAGTAGACTAGAGCTTGGGAACTCCTAATCTAGAACTATCTGCCATCCCACAAAGTGATTATATGCCAAAGGGATACTAGTCATATGTAGTGTTTCTTTCTGAAAAGAGAACTTATCCTAAAATTAGCCCTGGGTCTGGGAAAAAGGAGCCCTCTCCACCCCCAAAATGATTATTAAATTGAGATAAGTCCAAGATAAAACTCAGGATACCAAGGATAAATGAAACTTATTTAGGATAAAAGTGATAGAATCAGAGAGTATTTCCTCTAACCAAACTGCCAAAGTTGGTTTTGGCTAAGAATTTGCCAATAGTATTTACGTTGCTTGTCATTTTTTTAGTTTTCTGAGACAGGGCCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCACAGATAACTTGCAGCCTCCTGGGCTCAAGTGATCCTCCCGCCTCAGCCTCCTAAGTAACTGGGACTACGTTATGTGCATCACCACATCCAGTTAATTGTTTAAGTAGAGATGGGGTCTTGCTATGTTGCCTATCTGGTCTTGAACTCCTGGCCTCAAGGGATCCTCCGGCATGCTTTGGCCTCCCAAAGTGCTGGGATCACAAGCATAAGCCACCGTGTGTTTATTTTTCCCATTCCCTTCCTTTATCTGCAATGCTTTTTTCTTCTTTAAGGCAGCCTAATTTACAAGCTTGGCCTTGAATTAAAAGAGAACCCAGAACCCACTCTTAGAGTTTACATTCTCAAACCAGTATCAGCAACTATCTATCCCCATATAAATAAAGTTATCTACCCCTGCTCCTTACTAACTGGGTACAAGTTATGATTACAACTCAGTGATTTT + S&366643164>>37<898=8>9;>3HFFHGBB+B796FHD%BEEE9<4<48><597:;7<-<:448986:;7:?::=>;;4;<>>>;:=6?58;/;:6=<6,73+=>83=<579784<8;>6=89/=:4<5;>5;/<=:;:=9>9:>8==/><:=8=4<>9?9=<37<8==>:?:;;>=><9:+2:96><;>;8:.7+==8?=>2?????89:9?69:<8?<8<=>:78<;0;;:55<;8===<>>;>=?><=243;>>3>;ACA:>><<>>@56B=;;=?76::36=?A?C4B@>;?A><=>=1BB@BAA;AB>?9@??:7.,9;9643:8?A:?@@:?>C=@6=@?9?98B3===<,>9677394-=7A@;<;C=;9A=>:7A>2:>C@A??:A;B@;;?>A9;6;A8B9.??>>>=3:6,64@:9>=@4BC4@75;7<<6;5AA9@29;?4@:>6@BA>B3AB:=;91A>/8?A=>82<;;<;<<.<@@85><4;:C;+A?<<9><6/C?B?A;=8->=?<6AB86@?9>:7B:>C9A@0@>@4??7A1@CA8A:;=A:@1>@<674=BB:,BB>>CB=B@=$<9=9BA?@9>>@@C8BBCCBBAABAC?C@7C@BB5A1@5?@=>@6A+=@=;B=A6AAA7A@<;C=6@ACA>:C=A@=??-;=AA@@=;.><<>AB@BB?>8AA>>ABCBCB4@B@B:?=@?@>A<><9>?=18?@A:<9=39=<6>@1:;=?B7>;@@@'??=B93@>=@=4:A=?A@=9?6@>=2??=@=8==>6=B:==B9/2C@;C?;A:.==:>>;=BBC=<;CAB<>AA>CA=B>B6<<@BA=>@;9B@67??:C:A>B:@;BC52:>?7??C<8<+>6A@4A+54/<<*:46;-?BB@3?@:7@;AC?=><:>>>>=?AA@CAAA*>>A:<00B?8>B6>5A>A@?@798$=4;>?>@<8>=A?B+:>0:9A7BBAA;A=B:@@A95>96<=:<<7=@;9@1B?86<,;;==/9=2A9>9<B>7?@@>=::@B68=C:1???>-82??@?;5:4<9A<>BAC?<=A4AB:1A>;AA<9;=@@@;>8;=7,3KKKKKKKJ?JDKJGJKKKKKKKKKKKJJCKKKHKK3KKKKKKKKKKKKKKKKKKGKKKKKKKKKJKIKHJGJJKKIKKKKKGKKKKKKKKKKJ0KKKKKKKKKKKKKKKKKKHKKKDKKKKKKHGKKKKKKHKKKKIKKKKKJJKKKJKKKKKKIKKKKKKJ>KJKKKKJKKKKKKKCKKKIKKJKGKKHKKKKKKKKK0FKKKJKKKKEKKJKKKBKKKKHKKKKJKKKKAKKJKKKKKKJK.KKKKJKIHKKJKKIJEKIKKKKK>KJ;=HKIKKKKKKKIKKKJKKGIFKKHEKKKKKKKKIKDKGKHJKK@KFKKKKJFJKIKIK6HKJJJKKKKJKKBJFKKIDKDKKKKKKGKCKKJDKKKIKJKKKKKJKKKIKJJJKKGKKJKKHKBKKKKKKKJKKJKKJIKHKKKJKKBKFKJKIKJKJHIJJHKK@KKJKCKKJKKKKKKKKKKKKKKKKKK@KGKKFKJKJKFKGKJKKKKKKJKBKKJKKKKJJHKKKKFKKJKJKKIHIKKKKJKKKKKKGKKKAKJKKJKKKKKKKK>KKAKDKKKJKKKKKKJKKKKKKKKKKKKKKKKGKKKDKKKKJKKFKKKKKHKJKIKKKKIKKDKKKGJKJKIKFKKKKKKKKIKKKKKKKFKKKKKKKKKHKKEJKKJJKKKKKKKKKKKKKKJKKKJKKKKKIKKIKJKGKKKKKKKKKKKJKHKKKJIKKJKJKKBKKKKHKKKKKHKJKJKJKKJJKJJKKKKIKKKIKKEKKKK3KCGJKDJJJKJKKIKKKKKKGKKKKKKKKKKKJAHJKJKJKFKKKDKKKKK?KIKKIKKKKJKJKKJKFEJKKJKKKKKKJKKKKKKJKKKKKKKHKKKKKJKJKKKKKKKKKKKDKJGKKJJKJEI=GKIJKDKFKKJKJKKJKKK7KKKKKDGJKKKKKFGKKJKKFFAKKKHKJKKKKKKKJK2IJJJGKDKKKKKKKKJKKHFKIJKKKJJKKKKKKFK=KKKJKKKKKKKKKKKK2KKKKKAKKIKKKJKKKKKKGKKJKAKKKJK=K>KKKKJKKKKKKIK.KKKK?JJKKKKKKKKKJKKKJKKKKGKKEKKKEJKJK;KKKKGHDJKHKKKKKJFHKGKJFKKFHKG @rCer/1377/24_1934_CCS ATGGATATTTGGCATAGTCGAAAAAGAAAATATATTAATATTAGTTCAAAATTGTGAAAAATACCTTTAGAGGTCTAGTCTATTCTTTGAAAACTCAATTTTTTTCACTTATATGGCGTTAAAATGGAGCTATTTTGTACAATATGATGTATTGTTATTTTTTAAGTTATTTAATGTTAATATACATAGCTAGACTTAAGGTTTTCAGAAAGATGTCTGTAATAAATATCGAAAACAATGGTATTTTTTAAAAAATTGCCTTAGGGTTTTAAAATCTTCCCTACAGTTATAACCACATGTAATTTTGTGGAAATGATATAATAGCTATTAATACTACTATAACATAGGCATAAATATTTTCATGTTTATATGCATATACAAGTTAAGATAATTAAAAACTATGACTGCACCTAGTAAAGTCATCTAAGTTTATAGTTCAGTAGCTTAGGCAGGACACACACTGCTCATCTCTGCTTTTTAGGGTCAGAGGAACACAACTCATGTTCTGAGTGAAGGGCGTACACTGTACCTGGTGGTGCTCGATCCCCCATTTCCTCCTTCCAGCCAGGTCTGGAAGTTCAACAGCTCAAGCTTAACTTCATGTAAAGTCTTCACTGCCAGTGGGAACATCTTTGACACAAGACACTCCAATTCTGATTTGAGTTGAGGATCTCTGCCTGCCTTCCTGCCATCCTTCCTTCTTCCCCAATCCATGCTACTGTTAGGGGCTGTAGAGAGCAGCAGTAGAGCTGGAGTAATGATACAGTATACCACGGAGAGAAAGTAGAACCATTTCACTCCTGGAAGAATGAGTATTTCCCACTTCCAGCAATCAAATAACAAATGAAAATTTGCATACTTATTGATGTATTGTATGAGCCAGTAGCATTTTATGTACAAAACAGAAGTCAGTGCAACAGTATGTATGTGTGCCTGTGTGTGTATAAAAATAACCATTGAAGCTAACTTGCTAATGTACTTAGGCAAGCCACTTATCATCTCTGGGCCTCGTCTTTCCTCCCTCTAAAATCAAAGAGCTGAATTATGTGATCCTTGAGGTCTCTTCCACCTGTAATACCAACTGTCTTGTCAGACTGGCAAATTATATTGGCCTCTTCTTATGTGGTGGTTTTTTGGTAGGTCGTAGTTCCTTATACACAGACACCTACATCATCGAAGGTTTTTTTTTTCCCTAAAAAAAATGGGATTTTAGTTCTTATTCTATGGTAACTACCCTCCTCATATATTGGAAGGAACCAATATTTGGACCTTATTTTGAGGTTGTCTGTCTCAAAGAAAAAGAAAATAAAATATATACACAGGGTTCCTTAAATTGACATTTTTCCCGAGAATTGTGAGCCAAAGCCTATAGTAATTACAGGCAACAAATGATTCCCGATCTCTAAAAGGCTCTCTCAGATGAAAAGGGAGTAAAGGAAAAAGAGGTCAACCACTGTTTCTGATAAAGCACTTGAGTTTCATTGTTCTTTTAGTGTTTATTCTTATAAAAAATGTTTACAGTCTGCAGATTGATTTTTTTTAGTACTGTGGCTTTGTTTTCCTATTTTATGAAAAAAATGATAATCTTTTTGTAAAATTGTCTGTGAAATATGAACATTAATATATAAAGAAAAACCTTGAAGTGCTGTATAGTGAAGTATAAATTAATGTTTTCTTGATTTGTGAAGAACTTAAGACTATTATATAATTATCTTGCTGTATCTATTTTATGCATGACCTTTTAACCTTTGACTTTGCTTATTTCCCACTATGAAGGGGAAGGTAGATTTTATGAATGATTTTAATAGCAAATATATTTTATAAAATGAAAATCCAGTGTGGAGGTAGCAAAGCATATATCTGTTCTGAATCATGTTTGGAAATAAAATCGCTCCATCTGGGAATGTGCT + )$$)*(*(,*)-*(*/0.11+10100(0.()*%(&/,011*..0+2/'10//1,&-,00,1,/12,../1112,/-+.0-*((/+##%-)010(0,&+$+./0-+1/-,.-(&')4.&$*&/.2)(**('.1(31('#).),),35141*+,00&*/%/.013-1/141113%43//4-/,//-2025351*/&'--1146%.,,0/-*/1+&-+,,.2101(*355514.%,-/.&-1%/32%331,$$4344412515+-1-41)555/4154-264451-422-,150302/1*/52*&*3554/13.3141*/-3*,1415.+(1.6-14(/3)-(',+*+//3+33(3520/642.%*/,31101030/21.1202-'3150+..1+2)35452041355*341465140+440//+)/5/3/&0/0.1,(/0+1,011)/.-65203)/03./*)'**+.0/+&*)&-',*).,,3453,--(.,/,23-1,*2,.136.446144(.+1/.00-.(41%0323+11-/,**%/-./+*5105/*30)120514/.-3644096708745'$83/32-2061/./7*2+1/*461535.742-2.4605/9.3++%#43#&,$54.677'1-1.31734424:-758:968+26434-68499089/858*989&727,977893816/93815599%21-/:528/74593*-..84&625956-.047/356:7871244545$$(/669556.-7//71252?7939698038:826:+2593,9::745044'727:/7130:52-890<=2.05.402=7=17*894*<9%;473+>=<6<;<2:751463/721*31*137-895859:0:8:561*96655+.6%'054564;=955313;:5<=4<43+3323641694:,,*0*00+,2)$135:+%3/9<77=18283-1/'99972:59596359;?=0399?>74=8574:<=8764,>7:87<=;:=:=5<243=6:570<9=<79<775=766<6=>9;565====8+8<>;=9-5100).-,55=2;426=68<3%1/0:147$::9::0;:25>57=;39;=5=335=7;8>8><68.755097:>=>5,;<:$;2;77988;-<=1)49=;8;:44::8'896/58=<3=1/6:5<44;5543651=>65=4875423/;6<:92:8>;=0:482*9:?;2=5>9/7=:895:,4940982457%634).+784163<55386775/227:8<3>:2=8=97*77%--/2.%551817:-50+36<:<>93.;08835;4:68155:'7*4425*-33+21-/0%25694469475$86/*284776+6175/5*554).-23-'0211%7785065-6:2669852:7664.8:/2:918-6/86/302-:6/75038*1775:1606,1244)243$665/435(6-010442482365.4,1'234./4300217877283/792-:8779.6$54,.86#45887/*35:9;2,/57:98-)8863198013345;:55.64597+638888364;:.*666633399.4987:6:9859:7:587,76.35(2+866)7964+88:+97367.987;:39198:96242633/1746652487:88-45641+87548::85599;-967476:69;88808:7849607958:96670415*651+726280204/838:4:83/.54421*,&.*81/3//)13110,::2*3/2::9384.41.39/3983-21;9:6%.4634422/9737+37/(76'386619:63:6;65843.54465+9767:::6:4 @rCer/1379/25_1699_CCS ATGGGGGCAGGTTCTCTTACATCGACCGCCTAAGAGTCGCGCTGTAAGAAGCAACAACCTTCTCCTCCTTGTCTCCGCCATCTGCTCTGCAGTCGCGAAGCAGCAACCATGCGTGAGTGCATCTCCATCCATGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACATGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCCGGGCCGTGTTTGTAGACTTGGAACCCACGGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGTAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTTGATATTGAGCGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCCCTGGCCACATACGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGGTGAGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAAAGTTAAAATGTCACAAAGGTGCTGCTTTTACAGGGAAGCTTATTCTGTTTTAAACGTTGAAAAGTTGTGGTCTGCTCAGTTAATTTGTATGTAGCAGTGTATGCTCTTATATACAATTACTGACCTATGCTCTAAAACATGAATGCTTTGTTACAGACCCAAGCTGTCCATTTCTGTGATGGGTTTTGAATAAAGTATTCCCTGTCTTAAAT + J<:KKHKFJJK9KDH?@J@JI;I>IGGGIHJ:IC@KHKEKI@GEAEJGKF>KJKHAG-DBIKBG,JJIBI;KKIJJEKFIFEJ?HHJEBKFBB7IF>6JGDG6>JGIJDE9BIJ>KFGKF7AGK<+H/JKKJJ@HC?:CEGAFGJ7IF>GGC=G8A>HI?+?HIFCDF>KKEHJBDKD>HI@DBDCJBHDK?JJEKKJJDJKIIJJIJIKEH1KBKIGE@IHID>7FKHJEKJ@HGJI69ECGCJHHKG@HDBF2C<@ECJHGIED2HHHF?HJJ;DAD=6=H>@IHKCBGFJ=EEDHC@DIHCF@HFDEIKDI?AFDJKKKCGHEK@9@6HJEF:H6GFJ:JI=;IHHJEKCI89@IHKB$K?KJIJJG=EIAFGFCH::>:ECF@<:9B@BE'E=AE4E-CC@GB@BHII?ECC=JIHB2GG@CA:F74AA:537B;89BFCEECEHGG?JJJB?BJGDJHIII4FHFC<(DIFDC9@=8FHFFCHFDCEEEIJFHGGG@??GHCF@HHFCG6HDE>GJGA?BK5C@G9EJ78HCGFGEK?EIJ>J>GFEFJ?J3EAGA;HJHFJI8)EIJIIHDDBHJJ9F&>DFGGDJ=GDI?GEFG7HKHKIFBJJIJJFCGDFGF=IHGFKIJ?DC>C8D7DHD=HGEFIFGIFIJJHIJJGHK@HI:C;GIC-IHGGB;E:EAJEJEJFD=CHIGC=DDIJHGG>JKC7DHEEEEII1HF@;FDD@>8I;DJHK?I?JHJH;?I@CGDJ@F@FD,D:B=B?8;KIJBIHFJ6BHFFEIIF8KHKE&EGDHJKBHEFHCJI?KDGIH>JDFFGJJHFGGH=IIEBG%GD8EFJ=AH5F@CIEJF0JHHEE7JKDIDKHFI8@2>FGGGAJHICI;G5EJID:IA@GFDJDGJ>H>??AF?CE?CI7FCGJFJ?KE2GFIFJJJH@2GHE'90BIJBGB>AG.IHCGAADICG0DGEGHDGHG@IFH:DA=GIHJ;GIF3IG>A@CJ&FCHI:F@FK5GI?DFEFIF@E=EDHFE/FHKJ&G@GF55FIKIKIIADAEIHGIJJGK>=DKKKHFE9JEH?@CFFCIHGICDDII=JJJKIHDK@FEDHIEIFAG%C68FJIFCJJ;GKJIJFJDKHIJHCGI?KKG @rCer/1382/1984_55_CCS ATGGGGTGACGTCACTTCCGGCTTCCTTCTGTCTGCTGTCCCTGAGCACGAGCTGTGAGGGGATTCACTTGTGTGCGGAATTCCTCGGAACTATGGCGTCCCTTTCCCTTGCACCTGTTAACATCTTCAAGGCAGGAGCTGATGAAGAGAGAGCAGAGACAGCTCGCCTGACTTCTTTTATTGGTGCCATCGCCATTGGAGACTTGGTAAAGAGCACCTTGGGACCCAAAGGCATGGACAAAATTCTTCTAAGCAGCGGACGAGATGCCTCTCTTATGGTAACCAATGATGGTGCCACTATTCTGAAAAACATTGGTGTTGACAATCCAGCAGCTAAAGTTTTAGTTGATATGTCAAGGGTTCAAGATGATGAAGTTGGTGATGGCACTACCTCTGTTACCGTTTTAGCAGCAGAATTATTAAGGGAAGCAGAATCTTTAATTGCAAAAAAGATTCATCCACAGACCATCATAGCGGGTTGGAGAGAAGCCACAAAGGCTGCAAGAGAGGCACTGTTGAGTTCTGCAGTCGATCATGGTTCCGATGAAGTAAAATTCCGTCAAGATTTAATGAATATTGCGGGCACAACATTATCCTCAAACTTCTTACTCATCACAAAGACCACTTTACAAAGTTAGCTGTAGAAGCAGTTCTCAGACTGAAAGGCTCTGGCAACCTCGAGGCAATTCATATTATCAAGAAGCTAGGAGAAGTTTGGCAGATTCTTATTTAGATGAAGGCTTTCTGTTGGATAAAAAAATTGGAGTAAATCAACCAAAACGAATTGAAAATGCTAAAATTCTTATTGCAAATACTGGTATGGATACAGACAAAATAAAGATATTTGGTTCCGGGTAAGAGTTGATTCTACAGCAAAGGTTGCAGAAATAGAACATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAGCATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATTATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCATGCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTGGTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGAAGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAACTCATTCACTTTTCTGGGGTTGCTCTTGGTGAGCTTGTACCATTGTTTTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGATCTTTGCATGACGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCTAGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTCATGCTGTGACACAGCTTGCCAATAGAACACAGGCAAAGAAGCTGTTGCAATGGAGTCTTACGCTAAAGCACTGAGAATGTTGCCAACCATCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCCCAGCTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGACTGGATATGAGGGAAGGCACCATTGGCGATATGGCTATCCTGGGTATAACAGAAAGCTTTCAAGTGAGCGACAGGTTCTTCTGAGTGCAGCTGAAGCAGCAGAGGTGATTCTGCGTGTGGACAACATCATCAAAGCAGCACCCAGGAACGTGTCCTGATCACCACCCCTGTTAAGCATTCCCACGTGCCGTTGATCTTTGGACAGTTTCTAGCAAAGTTGTGTTTGAAAGGTAGTCTCTTAAAGAAGACTGTGGAATCTGTTTATTGGTGCCCATTTTGTATCCTTAAGTTTGGCTATTTAGCTGACCTTCTCTTTAACATAGGTCTAATTTATTTGCCTTGTCATTTTCCATACAAATCAGTTGATTTAAAAGTTCATTCTCATACTGTGCATTAAAATAAACATTGAAC + ??:14%>CE<>E>=*<,C9G?@D?E5C:A@?BB?ABFBBEC8GGD=BA@?>7@@:3=929<=ED?DG=?BE@B:CD?<@-FGGDC>=86GE:@8AADCFDA9DD??,FCC8;@A?@AAC@.=60=96:@D9>?AE@?@@BE=8B9B=?=1CA6;979C9@?<494<=7A997?BCCG=@B=*;:<:?A9A:?B%=;6%B?7>--;C>:59DDB3?6FEECFF@ADEB?>;CAC;@=A*;7@?D;=-=>E=BDBD<@@7AB?>;DBC*9;,7@2;BE.8;?7=.=5?4CD3A@CE7EAD5@<77=<=EE=DG9@=@B@>98>;<@D?<;,A<.@<>>8@;B@6@DBB=A;:C:D=4?8>3D=79.?>=8?42<9<5;5>;@BCGDE>29;<;@>?@9@87?@@BC7C;@@AED<<5=:68.7:>:C:<9;'<@=;/>AA<.@A;<>:?;444<5=B:4?==9@:5A;;>A>>9?:4A.258=59?0=A=?C@C639<42$078=<49:3@@>:<@=49@?C;5AC6B@?C8A0100<65=:%:-A;?@A@B?;@A8?9>A@0@@=*<9;A:=(6>2:>9==?<<4733<=;7?5:9?<;@@9=;?;A;A=5:?@4//89>?3?@<:4%,./02-A=BC79?>7?=*;=:=;82>8@3@858<=4<@>@7@>>1927B<;58224128*7?:150;::;5:98?=7AA?B9*1=.@>>=<2>6A7;=;298?A=<57<*>2@9C7BCB@:<4>/%/3=;=<8;2.;?>4:9A@79<=(:8>@>5;7,794@@8<'A;>=?;B:6;>6;@ABB8=?==:95/<<@79AA8<:4<<;.9=AB9?9252;9<:<::=7<98?;@C0>A@3:>73.=C9;7>;?:A05:052;;.96529;>764;.)75)+831'8.40>7><:7;)<86==191,47:&69:;6)<678418+61*/0-467816:31:/;=;51638;;24::;;<:8:389?266:->;4*2885967:9+=:26<;38:9<92=92361455357.05+6>>;<;2=569:=5?97:>:8.143;=8:31938/38*8;07295&029484357/=9171896603=9:<8<72827;96;>2<0<68;-:6$4614<=+:=581.585;:<6=9153<65086345591:43.9947?69<6-590:+392)92;42984<;;46><6=713862*369<9759:8/7;46;587.87466;<:095>;:59<>94=>043==7874969:>;87;=3<1=;78=98:,99<972.6?97987;289=6;<67.97478)7:<>68;29;5$::229=<3:.(6*57:808597>=0458;99<4997939575.6785.4).5+57>5.065847860<8199468)42(7%36354<%<8=>8.915957&3<=9?7875:69<0:81.66697-78987/,73/(46:6+206)9;:1/:4+')66(9<:97-597<.95;4>:.3:(0)0-0/35=;=::68;;:762:.46:)?9;>2;9)+988<>69;49:>9:-?89>=<9977=<<297:><>9<+<;4<71<;:=:?=?89?9<17$-15;8787:6=3542745+9:516-,&.1,: @rCer/1385/2274_47_CCS GCCGGCGAAGCGGAGCCTCCGCGAGTGCGGGAGGCCGCCGAGGCAGGCGGGAAAACCGGACAGTAGGGGCGGGGCCTGGCCTGGCGGCGATGGGATGCGGAGCACTACGCGAGTTGCACCCGTGCCCGCCGGACACTGGGGATGCGGAGCAGCGGCAGCGGACAGCGTCATGCAGAGCAGGTGGCCTGAGCCGGACCCAGTGTGCGGGATCCTGCGGAAGAGCTGTTCCAGGGCGATGCCTTCCATCAGTCGGATCACACATATTCATCATCATGGGTGCATCGGGTGACCTGGCCAAGAAGAAGATCTACCCCACCGTCTGGTGGCTGTTCCGGATGGCCTTCTGCCCGAAAACACCTTCATCGTGGGCTACGCCCGCTCCGCCTCACAGTGGCTGACATCCGCAAACAGAGTGAGCCCTTCTTCAAGGCCACCCAGGAGAAGCTCAAGCTGGAGGACTTCTTTGCCCGCAACTCTATGTGGCTGGCCAGTACGATGAGGCAGCCTCCTACCAGCGCCTCACAGCCACATGAATGCCCTCCACCTGGGTCACAGGCCAACCGCCTCTCTACCTGGCGTGCCCCCACCGTCTACGAGGCTGTCACCAAGAACATTCACGAGTCCTGCATGAGTCAGATAGGCTGGAACCGCATCATTGTGGAGAAGCCCTTCGGGAGGACCTGCAGAGCTCGACAGGCTGTCCAACCACATCCCTCCCTGTCGCGAGGACCAGATCTACCGCATCGACCATACCTGGCAAGGAGATGGTGCAAACCTCATGGTGCTGAGATTTGCCAACAGGATCTCCGGCCCCATCTGGAACCGGACAACATCGCCTGCGTGATCCTCACCTCAAGGAGCCCTTTGGCACTGAGGTCGTGGGGCTATTTCGATGAATTTGGATCATCCGGGACGTGATGCAGAACCACCTCCTGCAGATGCTGGTCTGGTGCCCATGGAGAAGCCCGCCTCCACCAACTCGATACGTCCGGATGAGAAGGTCAAGGTGTTGAAGTATCTCAGAGGTGCAGGCCCAATGTGGTCCTGGGCCAGTACGTGGGGAACCCCGATGGAGAGGGCGAGGCCACCAAAGGGTACCTGAGACCCACGTGCCCCACGGGTCCACTACCGCCACTTTTGCAGCCGTCGTCCTCTATGTGGAGAATGAAAGGTGGGATGGAGTGCCCTCATCCTGCGCTGTGGCAAGGCCCTGAACGAGCGCAGGCTGAGGTGAGGCTGCAGTTCCATGATGTGGCCGGTGACATCTTCCACCAGCAGTGCAACGCAACGAGCTGGTGATCCGCGGCAGCCCAATGAGGCTGTGACACCAAGATGAGACCAAGAAGCCAGGCATGTTTTCAACCCGAGGAGTCGGAGCTGGACCGACCTACGGAACAATACAAGAACGTGAAGCTCCTGACGCCTACGAGCGCCTCATCCTGGACGTCTTCTGCGGGAGCCAGATGCACTTCGTGCGCAGCGACGAGCTCCGGGAGCCTGGCGTATTCACTCCACTGCTACACCAGATTGAGCTGAGAAGCCAGCCATCCCTACCTTTATGGCAGCCGAGGCCCCATGGAGGCAGATGAGCTGATGAAGAGAGTGGTTCCAGTAGAGGGCACCTACAAGTGGTGAACCCCCACAAGCTCTGAGGCCTGGGCACCCACCTCCACCCTCGCCATGGCCACCCTCCTTCCCGCCGCCCAACCCTGAGTCGGGAGGACTCTGGGACCATTGGCCTCAGCTGCACATTCCTGGCTCTGGGCTCCGGCCACCCTGGCCCGCCCCCGCTGCTGCCACTACCAAGCCCAGCTACATTCCTCAGCTGCCAAGCACTCGAGACCATCCTGGCCCCTCCAGACCCTGCTGAGCCCAGGAGCTGAGCCACCTCCTGCGCTCACTCCAGCCCAACAGAGGAAGGAGGAGGGTGCCCATTCGTCTGTCCAGAGCTTCTCGGTCACTGGGCTCACTCCTGAGTGGGGCCTGGGGCAGGAGGGAGGGACGAGGGGGAGGAAAGGGGCGAGCGCCCACGTGAGAGAACTGCCGCCTCAGTGCCACTTGACATTCCTCGTCACCGCAATCTGAGCCCCTGGATGTCCCTGTCCCACCAACTCTGCACTCCGTGGCACCCTGTGCCACCCATAGGCAGCCTCCCTGTTACAAGAAAAGCAGAAGCAGCAGCGGGACTCCTCCCAACCTCAACCCCTGCCATTAAATCCGCAAACAG + 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@rCer/1387/23_2413_CCS ATGGGGAAACAGGAGTCAGATGCTAAGGGATGCCCACCGGCCGAAGGCAACTGTGATTTCCCTACCCCACAGGCGATTTTGATCCCTGAGTGCCGCTCCTGAGGACTCGACCCGAAGCTGTCCAGGGAGGTCCCGTGCATCCCACAACCCAAGCTGTGCCTCATGGAGTCGATGTTTAGCAGCCCTGCCGAGGCGGCGCTGCAGCGAGAGGCGGGGTGCCAGGACTGCTCACTCCTCTCCCGGACCTGGACCGAGTGTACGAGCTGGAGCGGTCGCTGGATTTATCCGCGACCTGGGGTGTGAACGGTTGCTTGCAGTTCCCTGACAGCTATTGGGAGATGCTGTGGCTGTGGCTGCACGACTGGAGGAGACGACAGGGTCAAAGATGTTCATCTGGGGACACAGCCTCGCAGCTGCTGCATGGATGTGCTGGGTGCGAGCAAGCTGGAGCAGGCTCTCATACATTTTGGCCCTGCCTGCTTAGCCCCCAGCCGCCATGCCCGTCGCCTTCGTCCTTGGTCAACGTCTGTGGCCTTGGAGCTCTGCGTCAAGGCCTTTGAGGCCCAGAACCCAGACCCCAAAGCGCCTGTGGTGCTGCTGAGTTGAGCCGGCCTGTGCCATGCCCTGGAGGCTCTGGCTACTTCCTGCGCCCACGGTACCTGGACCTGCTGTCTCCAGCCCAGCTTTTCCCGCCATGGGTTCCCTGAGTCCAGAGCCTAAGCCCCTGGAGCGTTTGGGCGCTACTTCTCTCTTGCCCAGGGAGGCGTCTAGAAGAGTTATGGTGCCTTCTACGTGGGGGGCTCTGAGCCAGCCTGACCCAGACCTTGACCCAGACCTGAGTCGGCTGCTTTTGGGGTGGCACCAGGTCGACCCTTCTTCTCCTGCTGCCCAGATACAGGGAAGACTCAGATGAGGGTGCCCGGGCTGGACGGCTAAGGGCACGAGACGATATCTGTAGAGAGGGCCAAGATGCCCACGTTGTAGGGCTGCTGCAGGCACACTGGGTGTAGCTCAACACCGTGAGGCAATGGCCCACTTGCGGAACCTGACTCAGGCTGCCGGCAAGCGTAGCTAGTGTTGGCCTGGGCGGCCCACCCCCGCCAAGCTTGCCAACTTCCCTGAGGTGGATGTCTTTGTGTTATTGCCTGTCCTCTGGGGCCCTAGCCCCCCAGCTTTCTGGTAGCTTCTTCCGGCCTATACTGGCACCATGTGAGCTGGAAGCTGCCCTGCACCCTGCTGGCCACCTCCGGCCTGGCTCCCCAACCTCACAACATTATGCAGATTATGCCTGGCTCTCCTCCACGTGCCTCTCCACCACCTGAGTCAGAGCTGTGGGAAACCCAGATGTGTCACTCATTACTGGAGATCTCCGACCCCCACCTGCCTGAAGTCATCAAATATTCTGGAAGCTTGGCCCTGACCCCACGGCCCCAGCTGGAACTGGCTGAGAGCAGTCTGCAGCCTCATTCCTTAGTTCCCGGAGCTGGCAAGGGCTGGAGCCCCGCCTGGGTCAGACGCCAGTGACAGAAGCTGTGAGTGGAAGACGAGGGATTGCCATCGCCTATGAGGATGAGGAAGCGGCTGATACCGTGTGGGGCCGGAGACATGATGGACTTATGAATGGCTGCTAGGACCTTTAGTGTTCCTGCACCAACCTCCCCATCCCCTGCCAAATCCTTGAGGACCTGGAAGGAGGAGAGCAGGCAGCCTTCATGAGGATAGGATCCATCTCTGATCTGTCCTGGCACTGGGCACAAGCTAAGCATATGCCCAGTAAATGCTTGTTGTTGGCTGATGGAATAAAGGGCTTAGGGATTCCCTGAGGCCTCTGGACCCATCTGTCTTCCTGGGGCAGCCCAGGACTTTTGGCCAATCCCAGTTCCTGGTCCCAGTAGAGGGTCTGTCCTTGTCAAAAGGCAGGTGCTAGCAGTCTAGACCACGGTTTCTCAAACTCATACCTGACATTTGGGGCCAGATAATTCTGTGTTGTGGGGCCTGTCGGTGTATGGTAGGGTGCTTAGCAGCATCCCTGGCTTCTGCCCACTAGACATCAGAAGCACTCCCCAATTGTGACAACTAAAATATCTCCAGACATTGGCAAATGTTCCTGTGGGGCAAAATTGCCTCAGTTGAGAACCACTGGTCGAGCTGGACGTGCACTGTCCGTACAGTGCCACTAATACATATGGCTAAACTTAATTAAGTTATTAAGATTAAAAGCTCAGTTTCTCAGTCACATAGTCATTCAAGTGTTCAGACAGCCACATGAGGGGACAGTGCAGCTACAGAATAATGCCATCATGGCAGAAAGTTCTGTGTTGGACAGTGTTGGTCTATACTGACTCTTATTTCTCAGGGAGATCACAGCAACCTGATAAATCAGATACCTT + """"""""""""""""""""$%%#"$"'%$"$$(('$(()%''$($$%$'(%((()())$'''#$'&)$$%%)%'(%(((())())(%%(((%('%(()))(()(%(%$&()))()$&%%(%('())%'(##(('#$%&%'))(%&+%,+)--+"&$%%&),&'&-*),-,+))&+)(*'#&&(-)+'-,'&*((-+--)++'*)%&&'%&%#***'+,-(,.-)&*-)-,'#$'(*'&)((-&'--(,,*-(,)()&%,(,-,()*+--*#,&$*)&('&'&&(%)'(++&'%$$$#'%)(%('&$&&%"&(()'&(*'&#')($$"')*),&)&'')%%&$##'(()&('&*(()#$'+,*(+++++)$(&&(($)*&**,-+'('',)'$(*#+)+(,,(),()'##(-+)(,'$+((&$*%(*+*)&&(('#'$&%%%*(,,''($"##%'&'$(**+,,&)-,')(,++-+-,&&$%$$%')'&%"$*&%+$#('+)'(&(+.,.,((',(-+-'&(,%'$+)+)+-),(,)-,(,,-,+*(+,,,,.)))-.-,$(&*,'&'-,-,*-*#,,+''(%%'$#$"#&()+'(+,(-+&&(,((&+(*),)&%(#((''&+,(,,,'+)'&&&''%&$%$)()+-+$-,%'),,)),+,,%#%,)+##)+,,,,(%*,+(+$)(%$((%(($$%(+&*'+(()))'*,&',+),))-(&,+&)')*)(,$+)#**+,*('&$''+%+('-*&))$''''&&$(),-))'-,,,$')&%&&$%'%)),,(%'%%((()('%%)%#'.,)(-,)'&')+*,''%'''&(+,,+,-++%+)$&(((((&')*(+(%$$')*-.+&''&('%''#(''**('-),*&()+**)+-,,-(-+&)(+,(,*#*,'--..-,&+++-.,'(,,-)-,)*-,..-,,,$((,+%(+-(&#*,,)+-)-,(+'$),&)%+,*(*$+',)')+*&)))$)*%,,,+)+('$,*$%&)((+(*&#%-,&''(-($$$(*)---'&++-+-(('-,--,---+,-*'*.,-&&+)+%)&$#('#()&+'-(-*)-,-,.(-+,(-,**'&,+-,((*-)-,-&&((--,)))-,)-----)*,&,-*)+((*#)*+-+&+(*&%,&#),-,),&,+))*+'&',*')(-,,+,+-*,.(-(,,-),,,-++.,,&+)()))%+-*)*)-')()#&(+(&%*..*$#+)*).--.-)*#*&(%$)')%*+,&,&++,--',',)-,,&+,-("%*$*,.,',*#','+#'*,$,--)()(&$,*(-,--)+,(,*+,--)),+,.-&*&#'*'(,**),,,*#"$&&),-,-.--,&,*'++(,..-*-)---+-'#*---,,'(('()$'+,*,.*--,$*'-(*,)---*..-'%,$,,,()$'&)),+)(-,*,--,),',+$'))',)-),&#(+-'(-,'-,..)-,*,,&,+,.,..,+(-()&'))+&*',..+*()+(''*(,,('+--,-#&(&(*%+,)-(*+(+-,'--))-,,-',--*+)++-,+.-(**$+)*+,+,)(----(+,)(((-,-'-(*&*($)*#,*-.-,')(+-)+),.+)+('*$)')-()(*+*,*)$*&'-,)-,-)+&#'()$&$*+*'(&)(%#$',),)#)-+$*((*,,(,*#(#')(,--.,(,(-),,%#(-,---)+,''$'+*-(((*-,,&,*&,)(++,+&$+&%$'$',-&#++---,'*'+-,-+))*---,-,'+*$+)-,-,)+''')+*,)),-+(-($,(&")"%(%((','+*,,+-(%,+''(')')%$$,&#)%+((+%%*,-.*,%,*'*.,*',(,.-((%,*.,*-)*#-*,,+'%%*+(((*,&*)-)%($&+*&'$*%))+&+*(#,--,&***).)+)*#,*),,)---,,((,)--+(+,)--,.,.,.,-))&+,.-+(+*)-*),...,-)-(##&)%&'***-,(,**,,'++-*)*-+&(--*,-*-.-)+%*)+&(+'('&,+&,+-)-,(+&+,,'-(++,+%''(%)',*(+,)&(**,----,,&,+)+++,-)*$(++&-+)&&++,)-+#*'+()(,+)--*-.*+)'))-*-,'+,-,(--,*(&%(('+#,((,,'$#'&*+$-*)%&&$(,*-+$)(*)($'$,'),++#'+(-(%#+&,**-*--,+$,,&))')----+#&*'',*--,.*(*)--,()*'(&*)(,*,($(+)('&&%''))))*--**-'&)--,.,-,-)%+'+),-*-','(+$+,-))*'$+(+%+,.,-&&'*,--*,)*')*$*)&*)+%,,,(+'*','')(+)--)#)+-,$*+))-,*+&, @rCer/1388/2265_59_CCS ATGGGGGCTCCCTTGGCGGCGAGCGGGCAGGCCTCCCCACACGCCCCCGCCGCCCGCGCCCCGCGTCTGCCCGACCCGGGTCGGGGAGAACAGGACCGCAGCAGGAGTCGGGGGCCGCCGAAGATGGGGAACACTACCTTCGTGCTGCGTGTCGTCCAGCCCCAAGCTCCGGAGGAATGCCCATTCCCGGCTGGAGTCCTACCGGCCGGACACGGACCTGAGCCGCGAGGACACAGGCTGCAACCTGCAGCACATCAGCGACCGGGAGAACATAGACGATTTGAACATGGAATTCAATCCTTCAGATCATCCTCGGGCCAGCACAATATTCCTCAGTAAATCTCAGACAGACGTGAGAGAAAAACGCAAGAGTCTCTTCATTAACCATCATCCTCCAGGACAAATAGCAAGGAAATACAGTTCCTGCTCCACCATTTTCCTAGATGATAGCACAGTCAGTCAACCAAACCTCAAGTATACAATTAAATGTGTCGCTCTTGCAATATATTATCACATCAAAAACAGGGACCCAGATGGAAGGATGCTCTTAGATATTTTTTGATGAAAACCTTCACCCTCTTTCGAAATCCGAAGTGCCACCAGATTATGACAAACACAACCCAGAGCAGAAGCAGATTTACCGGTTCGTTCGGACACTGTTCAGTGCTGCTCAGCTGACGGCTGAATGTGCCATCGTCACCCTGGTGTACCTTGAAAGACTTTTAACATATGCAGAGATAGATATCTGTCCGGCCAACTGGAAGCGGATTGTTTTAGGGGCGATCCTGCTGGCCTCCAAGGTGTGGGATGACCAGGCTGTATGGAATGTGGATTACTGCCAAATCCTGAAAGACATCACGGTGGAGGACATGAACGAGCTAGAGCGACAGTTTCTTGAATTGCTGCAGTTCAACATCAATGTTCCTTCCAGTGTCTATGCCAAGTATTATTTTGATCTTCGTTCTCTGGCAGAAGCGAACAACCTGAGCTTTCCCTTGGAGCCCCTGAGCAGGGAGAGGGCTCACAAGCTTGAGGCCATCTCTCGCCTCTGCGAGGACAAGTACAAGGACCTGAGAAGATCTGCGAGGAAGCGCTCAGCCAGTGCAGACAACCTGACTCTGCCCCGGTGGTCCCCGGCCATCATTTCCTAACTGCGGAGGCCCGCCGGAGGCCACACCATCCCTTAGTTTTCTCCTTCAGTTTGAGAAAAGACAGACTTGGGGTGGGTTTGTTTTTGTTTTTTCTTTCCTTTTCTTTTTTAACGCATAGTTCCGTCAGGCTGCCTGGATGAGCGCCCACGCAGCAAGGCTTGGAGGAAGCGTCAGTACCCTGGAGGTCCCAGCTGGCTCTCACCACTGTCAGCAACAGCACTTCCTTTGTGGAGGAAGCAGACTCCAATCCTGCAGGAGGAAATAAAGGGAAAGGGAGGTCGTGGAGAGGCAGGGAAAAATGATTAAGCGGCCCGGCCCTCTGGAGTCCCCGTGGGGGCGGTAGCTGAAGTTGGTGAGCGCAGCGGTGGATGCAGAGCTGGCTGCACCCAGGGCTGGACCGGTGTGTCCTGTAAGACTTCTTGCATTCCTTCTGCTGCTTTTTTTGGGATGGGGGGATTTTTGTTCGTTTGTTTTTGCCCTGTTTTGATTTTGGTCCCACAGAGCAGGGGATGTAGTTTGTACCCACCATTGGCGCAGACTTCCAAATAAATAGTACTGGTCATTTCTCTCCGCACTATTTCTGCGCGCTGTCTTCTGAGCTTTCTTCCTCACCAGTGGGCTGTGCTCGTTCCATTTCTGTACACCCTCATTTTATTACCGTTTTTCTTCAACAATGGTGAAATTGACTGTAGTGCTGAACCAAAAGTATCCCTTTCCCTCCTTATTCCTCACCCCAAGAGCATTCTAGATCACATGGGTGCTTGTGCCTTCCGATTTTCTTGCATTTGTTTTTTTCCTGACCTGAAGTTTGTTGTTACAAAATCAGTCAGACTTCGTGGGCTGAAGGACACTGTGCAGCAGAGGGTGTCCCCCGTGAGAGTTCTGCAGAGTGCTGGGCGTGCACCCGAAGCTACCGAGTAGGAGCCATTTCTTTGTACCCCTGCCTAATCCATTCCTCTCCTTCCAAGTCCATTGTTGCAAGCAATATTCTTCTCAATTTTTATATGTTCACTTTAAATCAAAGTTAGTCTATTTGTATAAAATTTTTTAAAAAT 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@rCer/1389/25_1869_CCS ATGGGGCTTGCTTCCTCCGCTTTCTTCCGAGTGGTCGCGTGAACGGCTTCCTGCAGCCTGGCCATGGCGCTTCACGTTCCCAAGCTCCGGGCTTTGCCCAGATGCTCAAGGAGGAGCGAAACACTTTTCAGGATTAGAAGAGGCTGTGTATAGAAATATACAAGCTTGCAAGGAGCTTGCCCAACCACTCGTACAGCATATGGACCAAATGGAATGAACAAAATGGTTATCAACCACTTGGAGAAGTTGTTTGTGACAAATGATGCAGCGACTATTTTAAGAGAACTAGAAGTACAGCATCCTGCTGCAAAAATGATTGTAATGGCTTCTCATATGCAAGAGCAAGAAGTTGGAGATGGCACAAACTTTGTTCTGGTATTTGCTGGAGCTCTGCTGGAATTAGCTGAAGAACTTCTGAGGATGGCCTGTCAGTTTCAGAGGTCATAGAAGGTTATGAAATAGCCTGCAGAAAAGCTCATGAGATTCTTCCTAATTTGGTATGTTGTTCTGCAAAAACCTTCGAGATGTTGATGAAGTCTCATCTCTACTTCGTACCTCCATAATGAGTAAACAATATGGTAATGAAGTATTTCTGGCCAAGCTTATTGCTCAGGCATGCGTATCTATTTTTCCTGATTCCGGCCATTTCAATGTTGATAACATCAGAGTCTGTAAAATTCTGGGCTCTGGTATCAGTTCCTCTTCAGTATTGCATGGCATGGTTTTTAAGAAGGAAACCGAAGGTGATGTAACATCTGTCAAAGATGCAAAAATAGCAGTGTACTCTTGTCCTTTTGATGGCACGATAACAGAAACTAAGGGAACAGTGTTGATAAAGACTGCTGAAGAATTGATGAATTTTAGTAAGGGAGAAGAAAATCTCATGGATGCACAAGTCAAAGCTATTGCTGATACTGGTGCAAATGTCGTAGTAACAGGTGGCAAAGTGGCAGACATGGCTCTTCATTATGCAAACAAATATAACATCATGTTAGTGAGGCTAAACTCAAAATGGGATCTCCGAAGACTGTGTAAAACAGTTGGTGCTACGGCTCTTCCTAGATTGACACCTCCTGTCCTTGAAGAAATGGGACATTGTGACAGTGTTTGCCTCTCAGAAGTTGGAGATACTCAGTGGTGGTTTTTAAGCATGAAAGGAAGATGGCGCCATTTCTACCATAGTACTTCGAGGCTCTACAGACAATCTGATGGATGACATAGAAAGGGCAGTAGACGATGGTGTTAATACTTTCAAAGTTCTTACAAGGGATAAACGTCTTGTACCTGGAGGTGGAGCAACAGAAATTGAATTAGCCAAACAGATCACATCATACGGAGAGACATGTCCTGGACTTGAACAGTACGCTATTAAGAAGTTTGCTGAGGCATTTGAAGCTATTCCCGTGCACTGGCAGAAAACTCTGGAGTTAAGGCCAATGAAGTAATCTCTAAACTTATGCAGTACATCAAGAAGGAAATAAAAATGTTGGATTAGATATTGAGGCTGAAGTCCTGCTGTAAAGGACATGTTGGAAGCTGGTATTCTAGATACTTACCTGGGAAAATATTGGGCTATCAAACTCGCTACTAATGCTGCAGTCACTGTACTTAGAGTGGATCAGATCATCATGGCAAAACCAGCTGGTGGGCCCAAGCTCCAAGTGGGAAGAAAGACTGGGATGATGACCAAAATGATTGAAATTGGCTTAATTTTTACTGTAGGTGAAGGCTGTATTGTAGTAGTACTCTAAGAATCACCTGATGTTTTCTTATTCTCCTTAAATTAAGAGGTATTTTGTGTTTGTATTCTTGGCTGGATGTTATAATAAACATATTGTTACTGT + ;9&9<<9=?=8178:;53;>>:89?>:7.&1357:9;;2<=4=5285?799273:7,<2<4.1>;=4853399*3)6:34';<.8/:<5'4;76=:2;7<<4891=5>9$5=>8;:&98154<;86=;32:8:==<>=55813*104429:<;2>:8.;52397=;99:;;&;%$81:::79<667:714043>?9:=3==;/=*9333:;+856=9=586576=4>:78:7?7=3848<24??<9=>609=7;<8;>79=>::99);;;2<;3:;;;,892;;643:;>:52>=::>>>1:>?>:<04:79*:748159,29:9;::9/=71482?=7:9/=+99<>=':4897:79)=/54:743=65&8485:.::<;=><==:3=5?:=6*37:/>')9/5:2;>>:;<&4<2<3<8=;::=9;7636<8-238>;?5>:>;;:98=70=9=18:::7002.986>/19:>'8<5=78>41>9<=>977$47983=;?879953:75<0;<189:>>>989:=9==159;;879<=?7:6957308:->C==;B79=:?>@A7A71?:?B>??:>>3@AB=>:BA@?C>97@5@;$989-8676>;8=0:49:=898<<@;=<(6A;0:=?.<<0C@:0>=?>B8CA55AB>B@B>@AC@C?C@3A7:0@<@A1>788&5-;A(8?<@>A?:=A:;1A<<3:9A<>1;>6A@>?*=?@><:=6>8.:7;>B>BAAA/=8B=@0;@?=A;A>8C9B?1<>.A=C>CA@A>C4=@>A4C?'=<=?9ACAC9=:=96397C=CB9C=?A698<><;886=A?8A>=;):5?AB6B@=??,>>?=C;>=?9<>AA@8-@+3/CE=FCFEBA?(A?=?>5CDED@FFB:AB:EC=ADB@F0?65?>9?AC<8=;A:D@B;@?AAABE/DB:EC?@7@?@F=E==ECD/CD?C=@E>>>BDE4?C%-3???@-?C<:8CCECE?$>B?F:D;@>?E@94=+6@=;;=:45179@7<=@<><3@?A/=5C=.@A3?>59A??B@CEEGD;9:?(6:9=27E=B4E2;C?>5?;@?:>>DEFC/DEAE=+E@0B8@@?EADF4BA7EBDGEDBC;E:GECBCE?><9)BB24=B9BAC>EBDEC<>E;GEE?E7C=C==7<:DCA?BF8C=>%?6ACF<@?>A;<@09??FBEABB>3CEB<6;->2C>8?>EFF@CA<@==BA#>=BDAED@B>9D@B:A83E>E3?AB?CE966ABFCC>=A:8DBBCB7E@D@:?B??DEC99GCD<<@DFCFEEDB75:;@C?:B@<5?A<>=A4>EGEF@9AFC1BEE4E9<=FAG>0DF2CF>EC'8?C>EA@&@<:D?3>DC=@A,EE3BBBEDF7C.DC=9?>6:AE5=96B<9C=@C34:;0@AA?4B@4;@>653C@CC?G7DEA:A?@-@?>@>=1@A@@D=C@=B3ED?DGEA@:>; @rCer/1391/25_2155_CCS ATGGGCTCCTGACCTCAGGTGATCCGCCCGTCTCAAAGTGCTGAGATTACAGGCGTGAGCTACTGCACCCCACCAAGGTTAGCACTTTAATCACCAAAGACCCCGTGCCTCTCGTGGTCCGTTGAGGGATCCCGCCGCCACCACCCCATTTATCACCTGCTCTTCAGGTCATGTGGAATTAGTTGAGTTTGCTTTTAGAGCTAAGTTTCTTTCCCCGTGTGGGTCTTTGAGGAAAACTTGAGATCCCCTAATCTGTGGCCCCCACACCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCTGAGAGCTCCTGTGACTGAGAGCGCCACGAAGCCTAGGATGGCGTCAGGCGGCTTTATTTGCTTGGCTTTGTAACTTAGGTGGTCCCCTCAAGCATCCTCGGTTTCTCTTGCTGTTTACGAATGTGAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAGGGACAGAAAGGACAGGTCCCAAGGGATGGGGCCGTCTTTACTCGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAGGGTTGACCACACAGCACCCTTCCGGAGCAGCTCCGCCAGCCCTCCGGACGAGAAACCACAAGCATGGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTCGGGTTTTTAAAGTGGGTGAGCATGAGCCTCTCTGACTGTTTCTTCCCTGGGGGACTGCAAAACCGCCCACTGAAGGCTCAGGGCTGCGGCAAAGCCATGGGCTTCCGGTCCCTGCAACCCGTGACCTAAGCGTGGTGCACCCATTACATGCAGGAGGACCAACTTGACAGACAAAAGACAAGCTGGGATGACTCAGGGTGAGAAGAGTCAGGGCCGCGCCTCTGTCCCTGCAAAACCAACAGGTGCATGGAGAGTGCGGCAGCCTGCACAGCTCCGCAAGGGCTCCCCCACCAACAGGGCCGACAGGGATCTCCAGGAACTTCTGACCTCACCAACTCAAGTGGACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAATGGGATCTGCATGTGCATCACATCTTTCATATGATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGAAAAAGGTATAAGCTGCAGTAATTTGCTCTTTGAATGACCGTCACCCCCAGTATAGGATACGCTTATATCCCCGTCACTCCTCGCGTTTTTAAATTTTTCCACCACCCGTGTCCGAAAAGAATGTTACAGCGAGTGCTCTTAAATGCTGAACCTGGTGTTGCTTCCTGGCCCGTCCGCGTGGCTCCATGGAAAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATTGACTCTGGGAATCCTACTGTGAAATCATGTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAACGTGGAATTTCCCGTGAGCGTCTCCTTCCTGCCCCATATCTGCCGCCTGTCACTTCACCGCCGTGCTAGAATACTGTTGTGTTGTTAAGATGACTAATTGTAAAAGAGCCTGCCCTGAAAAGTACTTAGAAACAAAATGAAAGAGAGGAACTTGTCCTTTACCAGTTTTTCATTTGCAGGATGGGAAAGTATAAAAAGGCACGGAAGGTTGTCATGGGCTGTTCCGTGGGGGGTTTTATCCCGCTCACCTTGGAGATAAGCCTGCAGCCTGTCTAACCAGCACAGCACAAAGGTCTCGATGGCTTTTGGTAACATCTGTCATTACAGAAGAAAGTTTACACGACGTCAAAAAAAGTGACGTTAATACTAAGTGTTTTTCCAGAAATACTGGTTTCATGTTTCTTATTGGCTCTGCCTCCTGTGCTTATTATCATCCAAAAACTTTTTTAAAAGGTCCAGAATTCTATTTTAACCTGATATTGAGCACCTTTAAGACGTTCGTGTGTGTGTTGCACTAATTTTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCAGTCGCCACTGTAAAGGTCCTAGAGTTGCCTGTTTGTCTCTGGAGATGGAATTAAACCAAATAAAGAGCTTCCATTGGAAGGCTTATATTGACCTTGTAACTATATGTTAATCCTCTACGTGTTAAAATAAAGTATAACTTC + 200653.,,650.611/*.23.4453*2./0344.6300.4.13..-652/1/24.4044+52055.*035.'4.0-342-11./042'00-.0655402*./2204(231+1,./.002/'3/-.2455-465263160,40/+2413-5,2/0+,,3424/5546540*21999698;:12;:582;9586676566:6-584'157289866;365208:669;;:8.9.7:392:843.838546/51415603):6684:756.567466255.5/7-9:86+751766'4/17(055.37;7346429:926380:4675;::5442236116:::3156555678992(41250842%868/3822676:6297.693*16897;.:9494/03;:313-15-59,92225,75616.645.84::447'73378+898:69;:6:57977799;4828.5109666;:163;9/98341.778639+6:87964491*583737738'8883;::6+57374758982:97::/6.666;:8849//395:8:193:8*845::8.:694/56460587;4:,26/9832349945)0.8:868$=55;9/-6<7;;=2::8543;7/71=>=)=8:3>::9>=;776868694/7<)892>;>;75?87'479<>;<946691=<;<26<::;>5578669=:<76;?<>413<&;:66:7'<=9<=><:4:0=<85/?66;7:=2:=:>:<=58===4<.;<9:3>>78)&4-4<9>>87296<;:7717;::73<9882=98?<>;>=1931:>36:8::>=45/5543/4;8;;<=4:2:=3.45765657=<;49?3=::;,477:6&78;+46?>=7?9881>>?=<999>:>99;61;<>>:2:=::75$658::=<977:859;8+*236<59;9<=>=;>8<;:6781;=:<,<<88=7:69;7<9??;4>6=><98;:;8:=<><>;?;2;8:<9676:=9<(7.-8=::794556<=47>=89?<94;>897;+8-=8<>8:866$72::<<<:;:;'89;:>:6;=>>:358;?=>;=4:6899:95/8=;;95=>88?97;4'999:<;=><>?4(4>:29>>97>=/<<<8869:<74=;8;/99<817;:<3=5;<9>;15>>:=;=:=66<9?<:=>7:5:7:7)88:;=;46?<;=3<193<<;<;998-97=9=7>9<3378964=3?;<>==>7:>;5=<7<7;>;?941;:4>6=979;:3<;845:97?=1==9<0>5+8:9?8:<>74>8?==78>=>9637:)3<=885=?:9=889=;<279=496;=7.8:<;739?1<=7:9<19=<=<<59<=097?<:&:757<97:::7;79<:9==;>659;;:;;=:><=6<=9?<3;9;;::79.5+5::<>76+676/973<87;;;58;8:'7)9:89*9::=9993=894=<838<8:>6?=;><9'+4:>1=:89?9==3%93:8==??<6/=?>>4::7<6;66==93<;.6==9/83>;2?;?8>087;6><-<;4:8167?80+9:<>90?>:9+/2:<>;54028>:<>>=:>86:=<:=;5/9=<82;:1=<8;>:::8;9+=>>37=<=;;6;<:>;8:97<:;+;8;=?>66;2572799=>>*:>:;:>,8;8:=3<5=;<<78===;2??=?<<8:2<<67<>9;4?;<992,797093477;=>>>>4=;4=54.1:8<>8>=:;:83:+=;976';<:<56;>=;;90?>>0=7=>>=7:=?5;<4><<7<99=>:;<:>2?>3=(8<839;95::563:<;=:64;:37.;:65=;>3><6=99=>>*=;<<===:===8.=->;>>;:6>8<<9;1>>7:4*28>:<:9?;4<8>5=?>>9<;;=?:;>>=?>?9?9??<;2;<13672-<5568<=6?>?<9*3818694;;=2/939;=565685<:=5;2999?8:8;=<589IKCJIK?DDDJJ5JIEB>KGKKKFK8KJ?KKIKHJKGIIIKCJ8JBK2KGKCJKKIDE1KKACKFK;JKKKEKKKAK7KJIK&KKKKKJAKKIKIGHJ@G9DD;KJHAFKJ@%H:C>CIIKJCKKKEDHB?GHJCKI=HKFFKIKFBB=E5@KHHKAJCIKHK/KKDHG:KJBEKJFJEIJFKJ:KGHGKDCKH1JKIHJHH-KJ;JKKIIKHIKIKIE:4KIJKJCDKK@I8E1D?55CA>K;9G>K?+,HIJ5GAJGKGKKJF;JIK58KCDJC7KJ'0HIIJH=J4)K?EEKKKK=J1KHG@FAKIAIKKKKIJ=DKJ,GKJHKIFIK0KE;JJI8JE8KKKKKKKI5KKKBFIKEK>JJ<6J/E6CJIIGJKDDKG69.BAKKGGH'IKKFKDK6KKKKFKKK>KCKH>JDKKJJJAKKKKIJ@J@=KIIKADKHJJKJGGKJHKHJBKGKKCKKKIG9KKJDKKI?FC=J8KCKKJKK&KKKKK5K;KKKKFKIIIKEJKJJ*JJIJJKCKIIEIKDKKJ:KJDKKKKCKKGEKKHKC=HKJ:KK8EJKKK?:KJJJ5BKKKKHKJJHBDE2CI2GK=>I7JHFHK;EKKFKKJFIG7K7=KHJ)KKJKCJJKKJJK/IF(KKK=H=GJK;KE6KJH>JJKE7KJK7KEKF-IJJKKBKK@@KKJHIKKKK=FGEJ?JJJKK5KKJKKGK*KKJKGGIKGK;KF0D@KKDKEE?KKGKIEBKJKKBH?KBEJJKFD9KKKEKHBKK7KKKIC@5KIKKKC=/:KI8KIJHI:0GE2IKHIJKJJ?DJ7;3KGBKKJEHKCKKK8K=FJ4KKIK4GGHKD9H:KGIEH7KKKDI@KK?KK@(?JF=J@KJBJ0KK8B?E7JKII<ECJKJFK?KJC)KIEHEFBDIJ=E;9CKIKF?5JGBKKJ5K@CJDC4KJ@JKFDEJJKB9CA':3CFFFJ;JBIC:KKJIJJKJ=KJH/K4JCKCJG;I'KDEGKKH=;IFHH?>?FK;KDHDF.KKKDD*HC*IIH=KE9;6$;:;+KIJK?9&BHIDFJ@AHJ9;G@KJI@IKIJ=KKJJI=>KD%KKJKIG8HIFJ6?B2?KI5K6K?B7&D3+EABFAABGCH;=G>JHF%AD=)BDFJGHF+JH0D=D;K=C=C3KG=JIJ@J?>5AHKI=;BA0A&@JG@3-4GHFJ+A?JGCKKGEG.J=HJHJAKCK?KHKJCG*JC<)E:H<.JIA@;B;GKDJHBAH4DKIFA7GA%BFHKK@9=I)CHHIDHC:BFHDJDEGBECFEIC3A0>EIG?J=JE@I=CCAD6 @rCer/1395/2098_59_CCS ATGGGGTGGAGCTGCCAGAGTAAAGCAAAGAGCAAGGAAGCAGGCTCGTTGGAAGGGGTTGTGACAGCCCCAGCAATGTGGAGAAGTCTGGGGCTTGCCCTGGCTCTCTGTCTCCTTCCATCGGGAGGAACAGAGAGCCAGGACCAAAGCTCCTTCTGTAAGCAACCCCCAGCCTGGAGCATAAGAGATCAAGATCCAATGCTAGACTCCAATGGTTCAGTGACTGTGGTCGCTCTTCTTCAAGCCAGCTGATACCTGTGCATACTGCAGGCATCTAAATTGGAAGAACTGCGAGTAAAACTGGAGAAAGAAGGATATTCTAATATTTCTTATATTGTTGTTAATCATCAAGGAATCTCTTCTCGATTAAAATACACACATCTTAAGAATAAGGTTTCAGAGCATATTCCTGTATATCAACAAGAAGAAAACCAACAGATGTCTGGACTCTTTTAAATGGAAGCAAAGATGACTTCCTCATATATGACAGATGTGGCCTTCTTGTATATCATCTTGGTTTGCCTTTTTCCTTCCTAACTTTGCCGTATGTAGAAGAAGCCATTAAGATTGTTTACTGTGAAAAGAAATGTGGAAACTGCTCTCTCACGACTCTCAAAGATGAAGACTTTTGTAAAAGTGTATCTTTGGCTACTGTGGATGAAACAGTTGAAGCTCCACAGCCCCATTACCATCATGAGCATCATCACAATCAGGGACATCAGCACCTTGGCAGCAGTGAGCTTTCAGAGAATCAGCAACCAGGAGCACCAGATGCTCCTACTCATCCTGCTCCTCCAGGCCTTCATCACCACCATAAGCACAAGGGTCAACATAGGCAGGGTCACCCAGAGAGCTGAGATATGCCAGGAAGTGAAGGTTTACAACATCTACAAAAGAAGCTCTGACGAAAGAGATGTATAAATCAATTACTCTGTAAATTGCCCAAAGATTCAGAGCTGGCTCCTAGGAGCTGATGCTGCCATTGTCGACATCTGATATTTGAAAAAAACAGGGTCTGCAATCACCTGACAGTGTAAAGAAAACCTCCCATCTTTATGTAGCTGACAGGGACTTTTGGCAGAGGAGAACATAACTGAATCTTGTCAGTGACGTTTGCCTCCAGCTGCCTGACAAATAAGTCAGCAGCTTGTACCCACAGAAGTCAGTACCAATTGACGCTGAAAGAGTAAGGCAAAAAAGTGAGAATGATCTTCAACTAAATATTTGAAATAGGACATACTCCCCAAATCAGTCTAGACACAATTTCATTTCCAGCACTTTTAGAAACTACCAAATTAGTAAACCAGAAATCGAAATTAGATTTGTGCAAACATGAAGAAATCTACTGGATTGGCTTCCAGATTTTAAATTTTATGTCATAGAAATATTGACTCAAACCATATTTTTTATGATGGGGCAACTGAAAGGTGATTGCAGCTTTTGGTTAATATGTCTTTTTTTTCTTTTTCCAGTGTTCTATTTGCTTTAATGAGAATAGAAACGTAAACTATGACCTAGGGGTTTCTGTTGGATAGTTAGCAATTTAGAATGGAGGAAGAACAACAAAGACATGCTTTCCATTTTTTCTTTACTTATCTCTCAAAACAATATTATCCTTGTCTTTTCAATCTTACACTTTTAACTAATAAGTGGATTTTGTATTTTAAGATCCAGAAATACTTAGCACATGAATATTTTGCTATAAAAGCATATATAACTATGTTTTAAATATCCATTTATCTTCTGTATATCTAAGACTTATATCCTTATTTTTACTATCACACATGAATAAAGCTTTGTCTCTTTCTTTCTCTATGTTGTATCACACTCATCTAAAACTTGAGTGGCTGTCTTAAAAGATATAAGGGGAAAGATAAAGAATATTGTCTGTCTCTATATTGCTTAGTAAGTATTTCCATAGTCAATGATGGTTTAATAGGTAAACCAAACCCTATAAACCTGACCTCCTTTACGGTTAATACTATTAAGCAAGAATGCAGTACACAATTGGATACAGTATGGATTTGTCCAAATAAATT + 90.;8%;=??A@CAA?::-;@C==?A:;7;;7?@@A4A0=>@B@;<9@5465%<5A==A:<=9@=A@AA6:1=>7AAB<.3;683=899681==<@<;C?@@.<@?A:B>8>;09?B8>7@@BC>>>BA;@?;8+?>BF@AEEFCD>+D@=@GB?@C=B@?FEE=;BCFB9DD=DD==9C@ADAEB-<B4?=?:>@)>E=CFDB5:?2:C<==ADBCEC@C?D==D:=*GGD3@7@==AD>3>=)C>A?,CDAG6@C>EAAEAC@@=G?B<=68@;8B=A/;D;3?'?FFC,A6=$?BC??DDEBE;B=>6BE;2B=2>GFEDEB@D8A?>DC?GDCA6BB>?:>D>0A=>/DEDC7BCE7F?>?DB>@8A7E-AIC9G9FFAIFBCIB@?C:ECCGC?EEABA?=779D;:AB@;FA?FB6@FCCE@EFFDDF8?;B>=1@D?DAE=7?2E>@2A@>C?G:ADAFG1EAEB;AECDBBE;AFDEGGG:=CBCCD1?B?CBBGC;EB?CC=EA<,5,DC7;GCAE6EF?ECD:@7@A@<4DC;D9*8DEDCD@EC2=CA?AC*:C9A;EF8D>BA=3DBAFBD?@CAC;@?A?D9;B@C9B5CG>>7AD5>AD;BC8;?BCBCA2BA7:C9BDCC8=B>>B;G7>E@?7;6A@@FEG;9AE>>CD<=@BA>?==?1FG@DE?EE@B;FG=@AAAD=?>*@CCDFA>+;CAB*;>BAAD8B>@GC:<*DCED?8AB8??;@*;5;6B0?@?GC=5>A@=:DA:6?D91$=ACDE7E:FD@=>:B>B-;@AB>:3BFBAD<7B?AED?7CBCCG5@G?DE6<;?>CA;BBADFE97A=E;?>?>?B?B6A>CB:,=4<@C/>A?863*>9B6<5=4;4694;90)6713063/64323%/85;89368399;378):4?C>BCB?:9CA@;5>:6>477>:@A;+4A.=B;;949=<=46:<757)=?A@)?<;:@A77;9(5<@?'@;>1:<:-=;;@@1?4=?6?9/>2A?A@4>:3;C3;<;0255:34<1>A:A=>?:A<<@@?;1*=?+/6<>99A72>99/>>A77=:7:?A.A:=*:41<>=?@5BC;?:<<;7?8;<;C@CB:9$/4:=:%407;2@@B>=;A;9A15<=;?8;,?AA(BA?A@1.:;>57?658;?('9:)23>C@<>?C:>C8;::47A:6B/?=2:4?A74@C6A;?>7=>>?3B=3:87<9$6<>29>>5=7<3:=;6;>5><59<6'25>8?580=AA>5B>05:;3<874@<<5A44=B=?B;:=<:<;A=/A>8:<:&=:<+:A6:1=@5;9=B<=A1..1;73*206;=*:45'316709:6;:9=:<<:>;:;>=>1:<3:;70877;/567>/:>38<=0=<<;,>:==92..382?3(=;<;&0742.00/.-.==4*2:>-:+9>4>:8<27:)732/15),%(/:691,560*6(5,03/46;9%;>8:)89>8=8=:<8+077'93*6=;5<8:*:9%:<==909920398;6<<;3775844+7+*<87-99?;;:693'301,/:6:<.5518:0:9/=569?5;=9796888<84-09;:;;<7B7<;;6A;>8CA5+C@1B3 @rCer/1396/0_1599_CCS CACGCAGTACATGGGGGCGAAGGTTCAGATCCGTCGCGTGCGGGAGCGGGCTGCGATCTCGCGCAGGGTCGGTGTGCTCGCGGGCTGCCGCGCCGCGACTCGTGCGAGTGGGCGTCTGCGCTCGGTTTGAGGGCTCCGCGCGGCGTTTCCTGTTCTCTCCTCTGCGCGGCTGCAGCTCGGGCCTTCGGCCTGATCCAGCCCCCATGGCTTCAGAAGAGCTACAGAAAGATCTAGAAGAGGTAAAGGGTTGCTGGAAAAGGCTACTAGGAAAAGAGTACGTGATGCCCTTACAGCTGAAAAGTCCAAGATTGAGACAGAAATCAAGAACAAGATGCAACAGAAATCACAGAAGAAAGCAGAACTTCTTGATAATGAAAAACCAGCTGCTGTGGTTGCTCCATTACAACGGGCTATACAGTGAAAATCAGTAATTATGGATGGGATCAGTCAGATAAGTTTGTGAAAATCTACATTACCTTGAGTGGAGTGCATCAAGTTCCCACTGAGAATGTGCAGGTGCATTTCACAGAGAGGTCATTCGATCTTTTGGTAAAGAATCTAAATGGGAAGAGTTACTCCATGATTGTGAACAATCTCTTGAAACCATCTCTGTGGAAGGCAGTTCAAAAAAAGTCAAGACTGATACAGTTCTTATATGTGTAGAAAGAAAGTGGAAAACACAAGGTGGGATTACCTGACCCAGGTTGAAAAAGAGTGCAAAGAAAAAGAGAAGCCCTCCTATGACACTGAAACAGTCCTAGTGAGGGATTGATGAATGTTCTAAAGAAAATTTATGAAGATGGAGATGATGATATGAAGAGAACCATTAATAAAGCCTGGGTGGAATCAAGAGAGAAGCAAGCCAAAGGAGACACGGAATTTTGAGACTTTGAGGTCCTTTTGGAACTGTGATGTGATGTGGAATACTGATGTTTCCAGTAAGGGAATATTGGTGAGCTGCATATATAAATTTGACAGATAGCTATTTACATAGCCTTCTAAGTAAAGGCAGTGAATTCTCCATTTCCTACTGGAGGATTTATTTAAATAAAATATGCTTATTAAACACTCCTGCAAAGATGGTTTTATTAGTACCTTGGTCATTGTTCAAGGAAGGGTTATAATGCATTCTCATGTGAAATATAAAAGCAAGTCTTGCCCAATAAAACGCTACATTGTGTGTATTTTTTGTTCAGCTAAGAATTGGAAAAGTATTGCTTGCCTTTAAGTTACTGACATCAGCTTCCACCAGTGTGAAAATTGAGTAAAACCTGAAGTTTTGCATAAAATGCAGATCGGTACCTGTGCTTGAAGGTTGCTGTAGAGCATCTGACCCCTTATTACCACCTTAAGCAATGTGTATGCCATGCATTACCATGCACTAATTCAATCACAGGTGTTTCTATCTAGATTGAAATATGTTTGTCAATGAATATAGAATAGAAACTAAATCTAAACATGACAATAATAGACACACATCTTTGTATGGTACCAGTTAGTTTTGCCGTGGATCAGATGGTTTATGAAAGTAATAACCATAAAGCAAAAATAATCTGAAGCCCGTCTTCCTATGCTCAATAAAGTTAAGTTTTTCTTCAT + $1+9(''.09(0&0/-444-:/987$.34,;;<>9>>;66:29<-';6:B975<;>>=>=>?=B8?4:7:8099=4<>:@;:AB@9=?EED<;698:>=<>:7(=::A?B:?:<)*9<=(B?@=)A>:9,?@=4;9-:;,1,0-8;7=64'49:19DDA7C:,<3<4';(:&<;54?37%9::67:6>;.;:6A2@;/893,68>+<;==BBF9B+:<<+<2240;89/>:191052974=<:<2/;<79<0+16(1<37@*4;:79>422139-322<'468.%<=:E<4882'B;7>77;<6<@?'CCE?E??><>BA=7?B428AED;=:6?AAG@A2E=.DG?<>C?77>:8G*A:5A??C6>CAI@:@GD:=:C;=B=:/BD*:?BA@CCC5-=>=;>BB?CGGE=F=7@7:/$=;8;>?5>>659>;?(71B?@;<8+?,B6/DC<8D2>@A9?3=4;3?*88289?>A6:8B@9F@D%?@=9@9D8A>.FC2=IE@8<86:A:=4:AAHC$74EE=/9BE.68?6JE;@D?GEA<>F:.>DB9>B68-94(:5297FDJ93D5J3(FBC@D?'@CB=H3EBD)?DBC96=F>E3IE@F6FF2D>@BG4F:-:=(DGEB3CAB/D=AA97F@8D4B48?DEEDFIE?FC>;7:A>&3?BAB?C:@,E<<:<>%;;':<@6@>9/6<;,?>@A@A3B<7(95D>398?4CF=;5>BBA7E:2HH:>CE5C@7(62610;=:/FD>DHGDH>;FGA*>31?&>9C.@?9;4<$<673DF?C0BF:B@6=?=@<;7=GCA6=3E;DF;DAGABF?-C>;18?EF=&?A@?CDB8DC?IBBBC=9)BFC@C1>FHFACA><5E@?C@9>CC4C)5+2:FA?A6837>?45@=8->BA=A83C3,5%((5>4;589;8;,;=@1B:)<)4+@9>>4AB==:E=DB,??A<:9'9?A:88<;C5B?=A7A/9+:<072;+-22.:;39A>55546(0)(.-&597=:@55/;+6>>6907E>7,;8>,7,:'??973=CB79@;4/8-621#;.-&2-?<221315?AC4@):>C@%@=;584@A>?4(9;.<:=2;&-=@?@8A>45+;:9CA?=F7B9%<>9=8:;;A; @rCer/1397/2416_63_CCS ATGGGGCTGTCTCGCTGGGACCCGGGTCTTGCTGTCCCCCGCTGGCCTCCTGCCCGGGCGACTGCAGCCAGGATGGGCCGGAAGGTGACCGTGGCCACCTGCGCACTCAACCAGTGGGCCCTGGACTTCGAGGGCAATTTGCAAAGGATTTAAAGAGTATTGAAATTGCCAAAAACAGAGAGCAAGATACAGGCTTGGACCAGAGCTGGAAATATGCGGCTACGGATGCTGGGATCATTATTACGAGTCGGACACCCTCTTGCACTCGTTTCAAGTCCTGGCGGCCCTTCTGGAGTCTCCCGTCACTCAGGACATCATCTGCGACGTGGGCATGCCTGTAATGCACCGAAATGTCCGCTACAACTGCAGAGTGATATTCCTCAACAGGAAGATCCTGCTCATCAGACCCAAGATGGCCTTGGCCAACGAAGGCAACTACCGCGAGCTACGCTGGTTCACCCCGTGGTCGAGGAGTCGGCACACAGAGGAGTACCTTCTGCCTCGGATGATACAGGACCTGACAAAGCAGGAAACTGCGCCCTTCGGAGATGCGGTGCTGGCCACGTGGGACACCTGCATTGGAAGTGAGATCTGTGAGGAGCTCTGGACACCCCACAGCCCGCACATCGACATGGGCCTGGATGGAGTGGAGATCATCAACCAATGCCTCGGGCAGTCACCACGTGCTGCGCAAAGCCAACACCAGGGTGGATCTTGTGACTATGGCCACCAGCAAGAACGGTGGGATTTACTTGCTGGCCAACCAGAAGGGCTGTGACGGGGACCGCCTCTACTACGACGGCTGCGCCATGATCGCCATGAACGGAAGCGTCTTCGCTCAAGGATCCCAGTTCTCTCTGGATGACGTGGAAGTCCTGACGGCCACGCTGGATCTGGAGGACGTCCGGAGCTATAGGGCGGAGATTTCATCTCGAAACCTGGCGGCCAGCAGGGCGAGCCCCTACCCCCGAGTGAAGGTGGACTTTGCCCTCTCGTGCCATGAGGACCTCCTGGCACCCGTCTCTGAGCCCATCGAGTGGAAATACCACAGCCCTGAGGAGGAGATAAGCCTTGGACCTGCCTGCTGGCTCTGGGATTTTTTAAGACGAAGCCAACAGGGGGGTTTTTGCTGCCCCTGAGTGGCGGGTGGACAGCGCAGCCACCGCCTGCCTCGTCTACTCCATGTGCTGCCAGGTCTGCAAGTCTGTGAGGAGCGGAAATCAGGAAGTGCTGGCTGATGTCCGCACCATCGTGAACCAGATCAGCTACACCCCTCAGGATCCCCGAGACCTCTGTGGGCACATACTGACCACCTGCTACATGGCCAGCAAGAACTCCTCCCAGGAGACGTGCACCCGGGCCAGAGAGTTGGCCCAGCAGATTGGAAGCCACCACATCAGTCTCAACATTGATCCAGCCGTGAAGGCCGTCACGGGCATCTTCAGCCTGGTGACGGGGAAGAGCCCTCTGTTCGCAGCTCATGGAGGAAGCAGCAGGGAAAACCTGGCGCTGCAAAATGTGCAGGCTCGAATACGGATGGTCCTCGCCTATCTGTTTGCTCAGCTGAGCCTCTGGTCTCGGGGCATCCGTGGTGGGCTCCTCGTGCTGGGATCCGCCAACGTGGATGAGAGTCTCCTGGGCTACCTGACCAAGTATGACTGCTCCAGTGCAGACATCAACCCCATAGGCGGAATCAGCAAGACAGACCTGAGAGCCTTCGTCCAGTTCTGCATCGAGCGCTTCCAGCTTACTGCCCTGCAGAGCATCGTGTCGGCGCCGGCCACCGCAGAGCTGGAGCCCTTGGCTGATGGACAGGTGTCCCAGACCGACGAGGAAGATATGGGGATGACGTACGCAGAGCTCTCGGTCTATGGGAAACTCAGGAAGGTGGCCAAGATGGGGCCCTACAGTATGTTCTGCAAACTCCTCGGCATGTGGAGACACGTCTGCACCCCGAGACAGGTCGCTGACAAAGTGAAGTGGTTTTCACCAAGCACTCCATGAACAGACACAAGATGACCACGCTCACGCCTGCGTACCACGCCGAGAACTACAGCCCTGAGGACAACAGGTTTGATCTGCGACCGTTCCTGTACAACACGAGCTGGCTTGGCAGTTTCGGTGCATAGAAATCAGGTGCTACAGCTCGAGAGGGCAGCGCCACAGTCCTGGACGGCGTGGACTGAGGCCAGGTCCTTCCTGGAGGCCTCCTCTCCTCGGGGACCCCAGCGCCTCGTCACCAGCATTGCTGGAGCCAAGGGTAGGAGCCCAGAACGGCACGGCACATCAGCCGAGAAGGAAGGAACTTTTCAGTCAAATTCCTCAAAAAGAGGCTGGAATAAAGCCTGGGCTT 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6-:?@/84A9:56BC?C=4>;;3=;6B=?9?C>AA@;<<'38=966)8447506*7:,86><29@9>>6?@;:5><0B:@;=1@:@;=A=<;<<<>3@??7923)<:4;?7?>:46.7463>A;AB8=C??>?:4:<%@CA<7=7>:3?>6.>:??0AAA=0>8<4;9A=B:A?6>3===@97?>>><;>,;55:<=1;=>>@+;@<>;=;5A>@9=4-;9)>:9BB5;BC&@;7214(236>9A4<<::63:&<@<@?-8:=@=?A?->85C88;;;@5@::;:<>7>B:975=<<-/>B?>@7.=:8=:2:-;;=@;:=B:>86=?@A>;.<2;;=:7?8B=6-;+6+:?=9<'2><95<=4=>7?7BA>B<9=<1@99<>82-=?=;????@;>>A<2<;=:?@@=<5@?@9@>?>9377A7=B?>:?9,7>@7:A>/A@84668464*6,0996?9<69=:;37,.55=;5>779/:5>51%45/<;95059>6:,59:74;$#)61:5,;78<=<1=<8>:+:>9;:>>>=C=;C<245)-*<=+4:834767.%6-9:88;--7852475253786396960.:4:2:988<8)<642528505+433;1)74/2;4=<859=:>;97<>2=0855<7:.59;68<742):;<3655256>>:49359>=4>=4224<;+69;;<;=;58:7769=5&90863/;8?;<69<6:113/7/356;/9?<=3:=;88=;;:1845;:4=859=397728><8??=1;66;<8&027:182<79888758'9;/14:72<84;6;::574687-85,>7;:<851;:5=9B?<@6:7<>7;8=<;<9-:695@997?7,;;=<9?C<>AA8;6@>7=3?8<=3@;=99?4;>8@A??<;7=94;:=5>9=A>A>?A=5B;BA?749>-/8:<)AA;687+2444983,26,%311:<3::46332:987;:6;=94:><1*3/660'27>9<90;>99219<9968%8;2<;>>>?8577942>12716.7-581:680::96;>84974889;64=;9<6969:5:7788/896465%9>;7:4:71738<:=4-8755<9;699<:6<9<74><9217>:17889:13&28;>:<::4<<62-<(9>;;6:;:95.&5<.07(5+1<57<<8/6*5=2895=;?;9:39/46&9?8659:53:229877878667:9957<7674>9=:98<-5156503/07>8<@>=9-@=><=@:707=7689:::;:68.3;;=8A79BAAB?4<9>1>>ACA;BB<:4?:C5CA:5BBA98@>>=3;BAA3;;<18=9AB=:<6BAA?=6>9B=5<5443:85>6;;1=7;=@@><>6?5:=/=7?5?>>:;;=92:=>863;/1BA;<<0119=3AB;48+49@A>4>989>?56/74917::->:==:C><>A?A>489>3;@@<8BB>7?=93<==?>8?A@BA?@=;6B?A9C=<6480?@893;;6=4=2:=79=B;9?=:?<7:=;<7:@56:<>;A6B?56:;1<79(->5=8:15;A??9=6<>6A2=32<;=<998>@>76549=/?;:B9A;=>BC?C>935;<:=+%8<7:8?16;<748:B46689A=?758:AA4>>,9<<=@:<694645=5=496:<;:(57$<;A5=;<97A:9;>@AA7A<302)7@<.89@@?9=B<5;4@;BA354@9=>>$6<2,>18ACABA5<=?<)A>A>;==?758@>>>1;6.8<<;5:>;6148:=>-8<77-=97>08:?<>6?@>:;:,9;=?:ACC?=74>-=5<<615=3>=@>+:=;;97<2:0=:>=B;<=:3365146?6$;A>?7<855AA>=>B@8=%33(4A?6A<+2157:@:@4??@A+AC=<9A6?B@<<88??&A@>B/A@A>C5<=?<8:5A@AA83>B<:8=;'4*>=;<>=<+>@;35?7AC:?5>@:;(A;>3@2=A??7@=@>B>A7A==;>@;458*=>9-BC?;@8=>A:=?8==?*AA4 @rCer/1398/532_48_CCS TATCTAGTGGACATTTAGAGCATAGCAGCGTGATGACAACAAAGATGAGGTTCCTATTCCGGAAGGCATGACGGGAGCCCCAAGGACTCTATCTGGTTCTTACTTCGTTTCTCAGACAATGCTTAGTTCAGTACTCAAAATGTCTTCGGTCTGTCTTAAATTGGACAGTTGAACTTAAAGGTTTTTTGAATAAATGGATGAAAATTTTTAACGGAGACAGAGGATGGTATTAAAAATGTAGAACACAATGAATTGTATGCCTTGAGTTTTTTTTCATTTTTACACAAAGATTTATAAAGGTAAAGTTATATCTTACTTGACAAGGATTTAAGATACTCTATAAATGATTAAAATTTTTGAACTCCTAATCTTTTCAGAGTATATGTTTTTAATTGATAAGCAAATTGTACCTCAATTTTGTGATGCTAGGACCATGAGCAAACTGAAAATTCTATGCACTGTCAGAAACAATAATCCATTTTTG + *$$%'$'&("###&&%#%'##&(#('#$'(%'&(%$&&$('%#$%('$%&)')%'$%#%$#&%%%##'))%$))%#%%%('(((%$$%$&$%$#"#)'()%'%''%())%##$$((')%'%$)'$%)'&##&%%&$%$#$'((&)('&%'%%$&&&#$##&&)%(%&%&'('$$)$$/'+)*+.//$*,)+).%/0,/'%'+'##$*'#0(*1/0//+(+),&/-.(&',$,020('&,-1-/-.-0(,*(#.&/,.++/&1,0-+222022.-.,'-.+#'--.*)%*%02+.0..'.*,*+*-,##($))*),'0*.+/1(00*-/$,---/-,.-(%)+.+1/-'(102),01+$'*($$%&/-*($.)0+11/)))-()0.1/,+(-+-0.0/&%+//1&,+.#*,)*)"(,'*%,&)+),''+'$%"$&((*',+,),($$$$$)#%+--,,)&#+-*+'$(%,)&&'#**&&,+,'#& @rCer/1399/2143_54_CCS GTGCTATCCCGGCGCCCGCGCGCGGCCACGGCGCTCCGCCAGAACCGCCGCCGCGGACTCGCCGGGAGTGGGGTCTCCGCTGGTGCCAGGCCCGCTTCTGGAGACCCTCCGCCTCCTGCCGACTCCTGCTCTTCAGGTTGGGCCCCGGGGCTCTGCGGCCGTTAGGGACAGAGGCAAAGAAGGGCAGGACGGTCTGGTTTTCCGTGGATGTCCCGCCCGAGAAAGACAGCAAGTTGTGTGTGCGCCCGGGACGCGGGAGGGAAGGGAGCCGCCGCCCTCCAGCCATGGACCATCATCCTTAGTACAGAGGATGGAAAGCTGATGCCCAGTAAGATTGAAGATCCATTCTGCATTACAGAACTGTGGATTATCTGTGGGTCCCTGGTGATTTCACGTCTTCATTCGCTCCTGCAGTCCCTGGACACTTACTTGGGGCCTCATTGGCCCTATCTGGTGAAAGATGGCATCCAGCCTGACTTGTACTGGAGTAATCTGGGCTTTGCTCTCTTTTCTTTGTGCTGCCACCTCCTGCGTGGGGTTCTTTATGCCTTACTGGCTCTGGGATCACAGCTGGGCAAGCCTGTGTCCTTCGGTACCTTCCGGAGGTGCTCATATCCTGTGCATGATGAGAGTCGGCAGATGATGGTGATGGTGGAGGAATGTGGGCGCTATGCTTCCTTCCAAGCATCCCCAGCGCAGAATGGAGGAATCTGCACCATAGTGACCGGCCTGGGTTGTGCCTCCTCCTCCTGGTGGCACTCACTGCCCTCATGGTTGCTGTGTTTCCGACCTCATCTCCAGGACAGTGGTAAGAGTGGCTGGAGGAATTCAGTTTCTTGGGGCTTGTTGATTGGTGCTTGGCTGTGCTCTCTACCCCTTGGGCTGGGACAGTGAGGAAGTTCCGGCAGACTTGTGGCTACACTTCTGCCAGTTTGACCTGGGGAAGTGTGAAATCGGCTGGGCCTACTACTGCACGGGAGCAGGTGCCACTGCCGCCATGCTGCTGTGCACATGGCTGGCTTGCTTTTCAGGCAAGAAACAGAAGCACTACCCATACTGAGATGGAGCCACCAAGAGCAGACAGAGAGAAGACGGACTGAAGGGGCTTGGAGAGGTCAAAACATCCACCTACCTTCAAAAGGTGGAATAGTAGTTCTAATCCAATACAATGCTAATAAAATGAAACCCGATAAATCAGGAACATGAAATAGGAAGGATTGTAGGAGATTTGTGGGGAGAAAAAAAGGAGAGTGTAGAATGATGGAGAAAATGGACCAAAGCCTAAAAATATTTGCAGGGCATGGGTGGTTCTATTCCACAAAGTATTGTTAATATACAACACACACACACACAACACACACACACACACACACCCCAAATCTATATATGCAAACAAGGGTTTGGGTTTTAGTTTTTTGTTTTGTTTGTTTTGTTTTAGGTTGAAAGACTCAGAAAATCAAAAGGGCTAGTAGAAACAGTGTTTATGTTGGGAAGCAGGGTACCCCAAAAATGTTCCCTGTAGGTCACGGCACTCCCAAAAGCACACAAGCACATACAGACATACGCATCCCCACACACACCCATGCACAAACGTGGATCATCGCACAGACTTTACGGGAGGTTTAGTGGTGCATTTCTCCTCTGTTTTCTTTTTAATATACATTTAAAATACAGTATTATCACTTTATAAAGCATATATTAAACCCAATAAATGGACCAATAAGCCAAACTATCAGTATTTTGTATATCCTGCATAACTCTGATGTAGTTTCCTCAAACGTATTTTCAGTGTTTATGCAGACCTTTAGAGTTAAGCCTTTGTATTTCCATGTTATTCAACAATATGCATATTTCTGAAGTAGTTTCTGCTGTGATATTCGTATGAAGAAAAGGGCACCTTTCTGTCCACTAGGAGAGAATTCAGCTGAAGATATGAGAATAGAGAGACATTTTCCAGTCATTGGATCGTGTTTCTTTTGTCCATTATTGTACTGTGCTGTACCACATTTATTTCTATATTCATTTGTAAAAAATTTAAAAAGTGCTATTTGTTGTATTTGAAAAATCTCTGTGAATAAATTCTCTCTTT + #)+,(../-%+,.,-)+'+-.,$$&/''*.,&-/.0+4/.+,-&6+5500/+121/03256/+/0(11-)+)$0002.&,+5,/.2*)4,+/$*(#&.100-0'.4-,55011,33126431/1*/.1+('((2,3./0/3),,0+10/,0..00+/-0(3-0--+'2432.41141,22345./&2*003*..553411*4*',,)*,#''0*,)-%11102/01101+0*'0,'++,,'-/-20).'+.(+.-)*-0-&(',0-/02//'--)+.*2.*-.1.,2/,0/*).00--,-1/)%),(,1,0/1*//+0/*)&,*02,-//1-1-1-,-/01.+-0,.-)+0-/(+,*11,1/...002/+(%%)(+0%.-/))/.+,0.-,),+,,.-/,%.-'00.,'0.*1-0.1)-2/-)**,((+-'/0-%(*0.-,,+%*+&0+(,0/'-)1.*./+/(/'/0*($2$0-/,,+1-11,-'..021-&.+)%,,*&*1-(++,.'(10//0+/1,(10/).*/-+11-*/00+1*-/)&&()+)+,1.1,),(.-/*%&,0+,+/.-,0'020+0+/*.-,1+2.-0+01-11+1+-+',,.++**&)%&)(,.,,,(),0+0/,**)//'**)/,/.&++&(%+*&++)01(-001102/.0,000--,&+''%2/,)$-/0.0/)+,,//&+2/1.---,%"$/-0-.21./*01-(/).),*,.-,,+*&$+*1/-/0+%+'&0+).&0+1/)%+,,+*%+'.+,$')/.,10-01*.+(--,)/..+00+*.,,&+.*0%#0/$$%*+'*-1)))'.'+*10-.0,-1-...',0+)%(,-1,,*&')&#,*010/./,111,1-/2/1,/1+1,11,11'/.),*%/+,,$-*#%'+1.+,'1/1(0.0+).-&.,$1/-+00*1000/0/0'1.,/,*-11)110--../'/.0-10.10.1.,*').#/+,&,*21+*+/*,*,),,.//1/)+,0/11++-%/-)&1.)/0//.*.,0+/1-(00$///211010,)(+*++,10-11..1,1/0&0212+'.,/-/01/0-&.1,-0-1.++/-/1-.02/*1+.+,.,,%*,/+-*+))/,/21/.1.1-01.0(,-,)(,/.-0..)-&.1/0,0,/**,-0/-,1..%.-/*,,/04(20%53-%.(-+3315(&'+,(/+1--)/).(&**(&.++,*/2-$+),-,##$-0.-0.&+&+-,/1.&%-),-/-..--'.1.$02/**&02*00/--1-,'()*%$*,(.-))0-.2/.-).-,1,/(/+/,.+-+0.**,,'0)*&+)+*,1/10(-0+-,-,0%*,*)%*)*/-+*()(&*./*.2/10'0/**.0)&))*12+,1*02/0.)-.#+1.&,*()--,$&+&)%&'*$$-22+/314*.(''$-*.&./403-)-43(01331).+(/,..-5355+42+/.11(,-44,,.%33121-.'-(1*4&)-*($+11036050304054.+4-2223150252)22.33261.210,0*-103.21/.-40.433)23131554/.+))*30,,)2004.//2.3644-/+11.-4'4566040+6/*$/565.--.54.102021.4511(23/11'4.04532.25&.56,3/42)/(401-&*.0-&0-45.51%,+0-200,&44,4*.14*2./02*1(462--*31+5652-1424624150-+022/533.1/#/3-2-0-34144//+,(33/%,443545/1*01/2/1-36244.''35(4-545.62.4'3*'-).021/+10163,-(,++.0,.-(/(%,066,$,))%1,1-02%,,/',+.+.,/4/3/++%/5+*453(31&0*/&/0)332064+/-340..,4611..415/150.*110)*(-+&#'+213.0-643.51.40/11-4).//.&.-1$1342)+36*)/-/)(3/-03.,-&)130222256..5300.-32*-+-,.4&0-0-.-1'15*-/.-%-141/%22'+/$),0/:041366#2+1/3.,*90-77(4-14/2578& @rCer/1401/1736_56_CCS ATGGGCTCTCAGAACCTTCCTGCCGCCGCGTTCGCACCTCGCTGCTCCAGCGTCTGGGGCGCGTTCCAACCTTCCAGCCTGCGACCTGCAGAGAAAAAAAATTACTTATTTTCTTGCCCCATACATACCTTGAGGCGAGCAAAAAAAAATTAATTTTAACCATGAGGGAAATCGTGCACATCCAGGCCGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTCTGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGCGACCTGCAGCTGGACCGCATCTCCGTGTACTACAATGAAGCCACAGGTGGCAAATATGTTCCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCTTTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAACTGGGCCAAAGGCCACTACACAGAGGGGGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTACGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGTGGAGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAGTACCCTGATCGCATCATGAACACCTTCAGTGTGGTTCCTTCACCCAAAGTATCTGACACCGTGGTCGAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAACACTGATGAGACCTATTGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGTACTCTGAAGCTGACCACACCAAACCTACGGGGATCTGAACCACCTCGTCTCAGCCACCATGAGCGGTGTCACCACCTGCCTCCGCTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAATTGGCAGTCAACATGGTCCCCTTCCCACGCCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAATATCGAGCTCTTACAGTGCCAGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAAAACAGCAGCTACTTTGTGGAATGGATCCCCAACAACGTCAAGACAGCTGTCTGTGACATCCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGCGAGGGCATGGACGAGATGGAGTTCACTGAGGCTGAGAGCAACATGAACGACCTCGTCTCTGAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCCGAAGAGGAGGCCTAAGGCAGAGCCCCCATCACCTCAGGCTTCTCAGTTCCCTTAGCCGTCTTACTCAACTGCCCCTTTCCTCTCCCTCAGAATTTGTGTTTGCTGCCTCTATCTTGTTTTTTGTTTTTTCTTCTCGGGGGGGGGGGGGTCTAGAACAGTGCCTAGCACATAGTAGGCACTCAATAAATACTTGTTTGT + EGKI?HFFDJHHI@FDKFGEB9H>KABFDGH@EJJKIEJKJKIEIGJEDEIIGKKK2KDKGK=JJKEIE>HGHC?HKFHBHGJJKKJD)EDKJIEDHE:/:H0IJHG6FGGDAFGJGK@HIKHDICFIIBAJJGED&J;J=HKGE;/=3-DGDD==;CE?F;IGBKBH>HEBKJJIC=I5KEHHKJIJKKGJJKH5?EJJIHGKIGJGCIJJC8@EADB?6BE.EGDI?JKJAJHIJKFJHJBI1J<>GKJJKD?IJE?IGHKJFECF/HJKHHFIKKCJJJAIHEKHH;JHGBAIEIJ@JJDGFIJKKKKJHD6GJCEKJIIKGKGAAABJFHH>?KBC=BIFKAJC:9=BBABF:FIKKJJGKKJI9BGKJIJGHHHKGIHFHKJJKK:JJHK?KKIJGFIDJHKICJJDGHEIGFKKKJK7IJKJKKJHKHIIKJJAJDIIJJKKGKKGGIHJJKIGF1IAHDKFKAKJJKK>JFKKJHJKCJKJAKIJJGKJJJGDJJJKJIIJ@JJJKFJJIJHIKKJKDKA@IKEKJIIDHIJKJKKJKJKHHEJA=$G@HJEKKKAIJGJJKIHDKKJEFII;EIFKKIIJC@GJIKJH1FKKIIJFFIAJIK;IJJI@F9HKBGKIKEIGKKIKIHJKHFGGADCCAHKJ=K@KJJIIJ>IHKKJKGJKJHEH;GKHJ7K@JFIJJEDHKKGHAGH@AB?F'DD8IGHAKIKIJKKFJKKKEKEJ8GIJIIIIK8EHIJIIHGH;JHKJJFGFIJJJH6JK=HJJD8GGIIIGDHKJHK9J;JJJJJEIIF4@;@KCJFKDJEF;JJHAFJJ8IIJIG6C9HIKE@IIJH9F2GKFKKKJI9GKJGFHEF?IJFJJIJGJJGECII>B4FJK;JHJJHGKFFIKJE:>BB89?;HE8KKHG;8KGKKHJEIF@AIJKKCGIKIJKHIKIHHKAHJIJKKKIIEEKICKIJJKDJKGKHFKFI5HIJJJJKKK8HAJIC@JK;KDII<;FBFJKDKJIJF@EJIGJKEKIH,CGHKKKCHKHHFHHCEGHEFCCCIH)?BJICJ;JEKFBC9GGIJFG@FIJD?D6@IHICJIIFICGCDKGKKJ6H@ @rCer/1402/1870_53_CCS GTTCACGGAGTAATGGGACACTTTCTCTTCTCCCGACCGGAGGAGCCGCTCTTTCCGCGCGGTGATTCTGGGACCGAGTCGAGCCCGCCGCTGCCGCGTCGCCTGAGGGAAGCGAGAAGAGGCGCGACCGGGAGAAAACGCGGAGTCGCCACTGGAGAGAAGTCGACTCCCTAGCAGCAGCCACCGCAGAGAGGCCGCCACCCGTTCGCCCGTCCCCTGCCCCGTTCACAATGCAGCTGCTTCTGCAAGTGGTACGATCGAAGGGACTATGTCTTCATTGAATTTGTGTTGAAGACAGTAAGGATGTTAATGTAAATTTTTGAAAAATCCAAACTTACATTCAGTTGTCTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGATCAAATGATTCCAAGCATAAAGAACGGACAGATCAATTTTATGCTGTTTACGAAAAGGAGAATCTGGCCAGTCATGGCCAGTTAACAAAAGAAAGGCAAAGCTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTTTCTGAGATGATGAACAACATGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAGTATTGTCATCACTTGGATTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGCTTCACTAAGGTTGATATGTACCATTGTATGGGCAATTTTAAGTCAGCTAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAAGCAATTGATGCAGCTGTTGTGATAAATAGAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAGATAACTAAATTTTAGATTATAAGAACATGGATTCAAAAGTGGCTGGAACAAATTGGTGACACTTACTGTAACTGCTGTTCTCCTGGTGTTCCTTCAGGATTTTTCCACTAAAATTTATTTTTCAAAAAAATTACTTCATATGATTCTATGTAAGTGATCACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAACTAGAGAATGCCCTAACTTAGATGGTTTTGAAGCTATACATTTGGTATTGTTTGACCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGACCAGATTTGTATTTGCACTGTCAAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTATTTCTTTTTTTGATTCAGCTTATACCAGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTATGTATTTACCATTTACTGGAATGGAGTTATTTTTATTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCTGTAATAGAATATTGTAGATGCACTTTGCAGCAGTTGGAAAGAAGTGTTGTGATTTGATTGAAATAAAACTAAATGTGTTGTCCTCTCT + !""#"#!),***)494,---,-1"(114.7799-769/8+4;895:-5598::.4-8999544')0(1+06&02&4-25/50.1/*4:/55'84%2)9505313257:2;886/407**/5,*43/53&85&&**04&'/-+,'.1',/(1)1/.*/1.1))310''-./)0-++).&')3,//,-,+0&.-,+/)*,)*&.%24+201.20-21+#-*2.1*42.+%$,%,4560'68.6*4+445%*78,5(4/49-9;478*8:92955,:3:7,030,34+22)7*28-31754.9,71,&(2)4*148972//10#34533&88+89)4;875086678;8944665++;664&.3721+16.*+%43155231)36:905450,+'457'2)/-3-20/53/024-67.933&7)*#((54%75534034049:867863/&,44.7:9,644337(7/))2118/8):1561404:34-$)73:*/568/358,9%8:92+77/4,3&4-9;552,/4/,)5)+,1(.30.+/&-)%*-2./)%2*/2.24+-6..322:.14,7.3+.-0.343)3/5696442+305,2+776085214&-.011,32815/56559252%.466(,82&83418'-69*/37673/1758/934645+047:7+-395743305755(220%-6/)-10-2/44/-%.-81:313'3/523++023356%88884*,9970*78356..54234:/-4-**+324*:323,1.4,2+,&.4:9832.758598407(:+26857.531*186*36+10*-/,9165224644'18+424876(153:55+140*($4.,,19633&51+453515*6)980313.84$/5355:45//484.03%&(76/4006.:.:987215:329992712.711::39:2+4195539268:237-.4&05>47.367:/6338:702%/5*;71989431;.;:>574/36&3357=:::=+3?99955&475,7394-9230<93558805.463374.297.;;;2;,;4<<6:=>:17<8,17:?<:0+&7815877-7;+/99:+99=6+%()5,8=?;=96$(41.0(,2.20%3-&$73968;*-6204<98:;0?8?>:>=><::<:&?7267>>;-2,%3/7<<&51--/00#8%42>91=::5564/609;;7;0=6517350=31+64=<9==:9969,209243<:;)7683==880386320%/1&2+,9('9:.432861=75+8:.<6:3655/78125+(318:+4249/8<::4865866*3541772+1/482693):6,2=0::127<3&3.79*9857772,45':7:93154&520/-701773%28:760/4506/3;3031#'16347(8698:6827;85:<9958=<9*<7:0968,897,:56901+:35/7;77=+;5=797<0:84&><:<=>=><15=65>:7==1;87%9367;66)1>889=2:83609678898=28756($,7%962)0(3:/+<4<:177+;41807>;800(8=9528&13946:39=8<723)025689=276$347>7.;:8*87:/):=<=>7(:49::86455577.8:(23$%1/8..72596'1627699+4983.3.28(650/:186;5//*53 @rCer/1403/25_1680_CCS ATGGGGGAGCGGCCTGCGCGCGGATGGCGGCGGCGGCTATGGCTGTAGCTGGCGGCGGAGGGGCTGGCGCGGCCCGCTCTCTCTCACGCTTCCGAGGCTGCCTGGCTGGCGCGCTGCTCGGGGACTGCGTGGGCTCCTTCTACGAGGCCCACGACACCGTCGAGCTGACGTCAGTCCTGCGTCATGTCCAGAGCCTGGAGCCGGACCCCGGCACTCCCGGGAGTGAGCGGACAGAAGCCTTGTACTACACAGATGACACAGCCATGGCCAGGGCCCTGGTGCAGTCCCTGCTAGCCAAGGAGGCCTTTGACGAGGTGGACATGGCTCACAGATTTGCTCAGGAGTACAAGAAAGACCCTGACAGGGGCTATGGTGCTGGAGTAGTCACTGTCTTCAAGAAGCTCCTGAACCCCAAATGTCGTGATGTCTTTGAGCCTGCCCGGGCCCAGTTTAACGGGAAAGGCTCCTATGGCAATGGAGGTGCCATGCGGGTAGCTGGTATCTCCCTGGCCTATAGCAGTGTCCAGGATGTGCAGAAGTTTGCCCGGCTCTCGGCCCAGCTGACACACGCCTCCTCCCTGGGTTACAATGGCGCCATCCTGCAGGCCCTGGCTGTGCACCTGGCCTTGCAGGGCGAGTCTTCCAGCAAGCACTTTCTCAAGCAACTCCTGGGCCACATGGAGGAGCTGGAGGGTGATGCCCAGTCTGTCTTGGATGCCAGGGAGTTGGGCATGGAGGAGCATCCGTACTCTAGCCGCCTGAAGAAGATTGGGGAGCTTCTAGACCAGGCATCGGTGACCAGGGAGGAAGTGGTGTCTGAGCTAGGGAATGGCATTGCTGCTTTTGAGTCGGTGCCCACCGCCATCTACTGCTTCCTGCGCTGCATGGAGCCGGACCCTGAGATCCCCTCTGCCTTCAATAGCCTCCAAAGGACTCTCATCTATTCCATCTCACTTGGTGGGGACACAGACACCATTGCCACCATGGCTGGGGCCATTGCTGGTGCCTACTATGGGATGGATCAGGTGCCAGAGAGCTGGCAGCAAAGCTGTGAAGGCTATGAGGAGACAGACATCCTGGCCCAGAGCCTGCACCGTGTATTCCAGAAGAGTTTATGAGGGCCACAGCTGTTGGGGCTCTGCCAGGTCCCCTGGGACCAACTACAGCTCCAGTCGGAAACCCTGAGCTTCCTTGAGTGGGGCTCCCCACTCTCCCTGCATTGTGGAGCTGACTGACTACACCAGTGGGGCTGGGGTCTCTTCAGGGGATTTCACTGGAACAGTGAGCAAGGGACTGCTGCCTCGCTGGTGCTGGGTCTCTGGTTTGCTGCAGAGCCGTAGGGCACTCCCAGCTCCTCAGCAGGACGGAGGGACCCAGGCGGGTTTATTTTGGGGTACTTGTGGCATTTTCCTGTATTGTCTTGGACATGGGATGTGGGGAGGTGGAAATGATGAGCAGTAGCATCATTCCTCCCTGTTGGGTTTTAGCCAGTTTGCCAGCAAGCACATCCTAGCAGGGCCCCCGAGCAGCAGGTTGTGTGGATGAAGGGACAGGCACTTGCATCCAGCTGATCTAGGTCACACCTGGCTCTTGGCTGCCATGTGGCTTATTAACAGCTTCCAGTGGAAGTCGCAATAAACAGTTTCTGGTAAATC + KK-KKKKKKKJKKKKKKKKKKJKKKHKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKK=KKKKKJKKKKKKKKKKKFKKKKKKKKKKKKKJKKKJKKKKJKKKKKKKKKKKKKKKKKKDKKKKKKKKKKJKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKJKKKKKKKKKKKKKKKKKKKKK2KKKKKKJKH/IK;KKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKHKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKK5KKKKKKKKKKKKKKKKKKKKKHKKKAKKKKIKKKKFK6KKKKKJKKKKKKKKKKKKJKKKKKKKKHKKJKKJKKJKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKJKKKKKKKKKKK9KKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKIKKKKKKKKKKKKKHKKKK>KKKKKKKKKKKKKKKKKKKKJKKKKKKKK=KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKK1KKKKKKHKK?KKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKIKK(KKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKK@KKKK>,:3?7;194;>:-;=>?>=58:7:1<55>>>>>?583>>=9>>2;?9?=<*9>?=?::08<1;9>=:=69=;:>>?:>9>???179=9==;?=>;>=69::->=9==9=9<5<>:8;;5'9<=;83=871429=<>>:+:;9>55>?>325<;=7;?=99059>=9<>9??=;<8;:1>8:=99945,89>?85;=>->?=:>?=?<===9<>>.=:>>:9>6>?==;6463>9=6;>>;2>?===<<=2<:55%9828:+:2;=2;3=;<=.<8>:<82;68=::;+=?<=6;8<<:<*-/6/27=84=<3;?:>;7>=78===9*2>;6;9;58;;27599+5;56;;;586+98966878.70.769;899+8/;75796/774:;;48777,695-7338:78.8:883/.744:8987338959:6:97417998%5.:4:8/5.39:48983:6:::993;::989,433:652::288.96*868:9588.:;7486008(9694:::993.89:82:;9:657:::13996:;77936::::3592934:/6::16:8.89889:9+:8:977309:768-1:::;;8:97476736-.18:5221.3-978:73929/5:8/:92:9576362827:9;;8414.438-997886:::86-7+6::786.::15755&68-997299;2:977:6285:5:9::5799615*0:0::98;6/:3:::842/74:.9:;8849949379*795958::392.6:::98/;9::99::8:859:::65/99:/995;99::89:2::9:7798979;692:5:::::7:889574:699987:9325-754&9998/,033.9:3::52:::8685;7::9/9:7.79/36:::9327156795)34796/:86726-;8:2:855:967/3,18:9::16582595479995699+76:73)99875:55:92:::::679:9:..9773777&819729:88928:736:;::67/68/49.8889:,+3,/($14,78848863(949927996)9/9955986(;999:95695/5466$8::/445459.39;.56.8128882496929:841::9:::::05667757:82890647198:703747525537,29501588'27885837.31/2:13-6256662**&'778734819888660:57296497884416899797759987959336;7:957*668+5;846558-164657988)76895.769:9/68:899267;5653.;:/884;99.;73359:99;86792:56842,:4:::5869586,19.8::8-877:1215+39293809578'7320-5455):6:;:5:::5:992:;:742:;44635;756668-2673.777)6)2685*59:::3;8446&75735982989559:99:558:876.47959+775689688/9::7:9375::::694:6596;97992898:;586965849:26449)796-+2-.96285;7473851988986:7,65$1+186447877'106+45:7;94287(08566+9:9:.19:9679995868342986;653:188186184.28391157882,466+708,:9::862:::975996:/576&6&7740:5:734.:76:2:775:8235793::/38;99499826318623+67;46675755909949+566.9::612006891409::5+:::;429212866:8::/858:6576447:959;:8:;9648.4/5577788-45:5767649:9889,7909:378*15:7734.387799183,/450+4696.6488.99843(,/6458,45976747.8654.3076795:/5419/:889448386/74878(:65:647.954589/6966-74/150-$837::983:9,758:865-83.265242127::962559,896739779858484-76857938062,558676332/(454:9830:992.46:99354997'46,69/8699.98993'014,76462521899,/5)4/702-969:8;:68:59:292:;7;71:7::6449:,:78:5424749903939967:5+830674219782:57,1890489:42:9897.:82::4.2797*376-7905986596:9967786899;89:9855835148:74266.6779:9982:65372:2.8/6:896:949606'76.437)8297;9856674.784888-96,171:7:975585469,47609:2888::/4+9867304454-.3178;:;8477::::4:7960987616:77855;66:::/795;;399.1:8258+9862780005930+998.857-021/'649895:9/;9785:956,333-129632::166;66799;;921-5942-3:.59:9704:;8:;;;9683885896589466'68789952854-58:.7697;62648815467/586:::94928677078/6;8:8940951::677$6628588/140:999375:99:90+34::906998-17175963577&593251915;8953+557-99:6:98754*9;:/579::41/8:59:::17:7'465&3:93379883+245242+/5(5664142631#445-424)./50)451164,566466/-1.23&/555)64422-$5%3546.15+45.63642666525'044254632'466604*2133443&2260233531143%//36025-.0023123$54*0/2452/.0$&63/2444244$45555(6 @rCer/1409/1723_58_CCS ATGGGGAACTGAAGTGGCGACTGAAGTGGGTCAGAGCTTTAAGCAGCAGCCCCAGTGCCCCAGAGACCTCCTAGACCCCTGCCCAGAGCAGGCAGCAGGAAAAGCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCAGCATGTTCAACAGCTCGGAGCAGTCCCAAGACGGGGACTGTCGGTGGCGGTGCCTGGAGAGATCCGAGGCTTTGAGCTGGCGCACCAGCGGCATGGGCGCCTGCCCTGGGCTCGCCTCTTCCAGCCCAGCATCCAGCTGGCCCGCCAGGGCTTCCCCGTGGGCAAGAGCTTGGCAGCAGCCCTGAAAAACAAGCGGACCGTCATCGAGCAGCAGCCTGTCTTGTGTGAGGTGTTCTGCCGGGATGGAAAGGTGCTTCGGGAGGGGAGAGACTGACCCTGCCGCGGCTGGCTGACACCTACGAGACGCTGGCCATCGAGGGTGCTCAGGCCTTCTACAACGGCAGCCTCACGGCCCAGATTGTGAAGGACATCCAGGCAGCTGGGGCATTGTGACAGCCGAGGACCTGAACAACTACCGCGCTGAGCTGATTGAGCACCCGCTGAACATCAGCCTGGGAGATGCGGTGCTGTACATGCCCAGCGTGCCGCTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTTAAAGGGTACAACTTCTCCCGGGCGAGCGTGGAGACCCGGAGCAGAAGGCCTGACGTACCACCGCATCGTAGAGGCTTTCCGGTTTGCCTATGCCAAGAGGACCCTGCTTGGGGACCCCAAGTTTGTGGATGTGACTGAGGTGGTCCGCAACATGACCTCCGAGTTCTTCGCTGCCCAGCTCCGGGCCCAGATCTCTGATGATACCACTCACCCGATCTCCTACTACAAACCCGAGTTCTACATGCCAGATGATGGAGGCACTTCCCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGTCCGCCACCAGCACCATCAACCTCTACTTTGGCTCCAAGGTCCGCTCCCCAGTCAGCGGGATCCTGTTCAATGATGAAATGGATGACTTCAGCTCTCCCAGCATCACCAATCAGTTTGGGGTGCCCCCTCACCCGCCAATTTCATCCAGCCAGGGAAGCAGCCGCTCTCGTCCATGTGTCCAACGATCATGGTGGGCCAGGACGGCCAGGTCCGGATGGTGGTGGGAGCTTCTGGGGGCACGCAGATCACCACGGCCACTGCACTGGCAATCATCTACAACCTCTGGTTCGGCTATGACGTGAAGCGGGCCGTGGAGGAGCCCCGGCTGCACGACCAGCTTCTACCCAACGTCACAACAGTGGAGAGAAACATTGACCAGGCAGTGACTGCAGCCCTGGAAACCCGGCACCATCACACCCAGATCGCATCCACCTTCATCGCTGTGGTGCAAGCCATTGTCCACACACCTGGTGGCTGGGCAGCTGCCTCAGACTCCAGGAAAGGCGGGGAGCCTGCCGGCTACTGAGTGCTCGGGCAGACAAAGCTGACCAGCAATCCAGGGACAAGATACTCACAAGGACCGGGAAGGGGACTTTGGGGTCGTGCTTCCCTTGTGAGTGGCAGAGCAGCACAATAAATGAGGCCATTATGCCAGGCTCCAGGCAGCCTCCCTGGCCTGGCTCC + A=CDE,A9AGBC)EA?AEI>G@EIDIDFFF%GCED*D=B>IIF?D=FFCI9IHI?IBEGFF5BIGGAF8BII@ECAD=3FDB7H=C@CHE8AE,BB*DEEABE@ECA(9EII-?=;HBIAI@HCE?EB?DCDG?EGIIFGFGGIIKIBCEHHGDFIFCIJ?HFI:HEJI(IK,GJKEKK>KIKJCK=IKG6AKI=1?EC=HGKEJKJKKJJKHCHKKKCGJKEKKEKKEK?KKIJKCKI8JKKKIKJJKHKIFCGJKIJKKKKKIEJHK&KKKIKIBKKKKKIKIKIIIKKKIJJKGKFJI=JIKKDKJJJJGKJCDIEHDKKCJGKJKHJJKKIKKJJKKCJKKKJHKFHKKFKGHKJCIJJ/KIJKIJKCJKGKJGIJK6JK7JKJJKK:KK4IJKHHKHGK@JJKAKJI;KKGJK?KJGJK)H>KJKIKKIHIKKKEGKK.EKKKAKFFGK0JJKJKKHK@KKIKJIEIK6KKJKKK8KIJKGK:FKIKKJGIJK>KJIHIKK3KJJJI1KK;KKAJJJJKJH>JIGHBCHK?E?JJKAF8?IKGKK@KJCJKKKK:KKIKIJKFKIJKKKKKGJH2JAJJKKFK2FJJKIKJIJKHIJHIKKFHKJKJIKGJK6JJK8JGJGKJJKHIFIAJJD@GDHGIFKCHH8KKJGEGCEFE4J@IIECJFHEHKKIJIJ6FDII@4HI;GKK2KGJKDH;JKKK6IKKHIHKI?JEGIGHJDJ3EFHGGBEGDDIGEEHIIGIHKIG4BJKK9K3IGI?KJ>HHKKK7I:H@G?CFKGJ>IJHK?KDJJK.KBHIJIJHD9G?IIK;HEGGJJ@IBJ>ICK3II;IGJKKGHFGI@HGJ6KKJKK;DI1KJICKADJHIGBJG2JHJIGKHHGHEHKFJJFAHJFI>HHJ>IHIIHIJCGJ:>GDKIKDJJ3KI7KFKKIDI@KK9KKHB?;:<:8?1><97,0<0;861187887.,1686,5%,,14461'3-0522-(4/)'5,*1+)+$(010--/65$4496/34/43635/4:*4793/5*6794415'*/5.66..04/6/0542123382.60,$&,5124125856./75+36/86-77561365/+4:662..-.1.+1624401)04-.0895500789592,/,94.5:5;92'50..01:/4664.4&(/+2,#**. @rCer/1412/2361_51_CCS GTCCGTCCCCGCGCTCGCTCCGCACCCCCCCCACTTCCTGTGCTCGCCCGGGGGGCGTGTGCCGTGCGGCTGCCCGGATTCTGGGAAGTTGTGGCTGTCGAGGATGGGGGTCTGTGCGTACCTGTTCCTGCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTACCCCACAGGAGCTGCCCCGTGCGCGCAGCGGAGATGCCACCTTCCCTAAGCTATGGACAACGTGACGGTCCGGCAGGGGAGAGCGCCACCTCAGTGCACTATTGACAACCGGGTCACCCGGGTGGCCTGGCTGAACCGCAGCAACCATCCTCTATGCTGGGAATGACAAGTGGTGCCTGGATCCGCGCGTGGTCCTCCTGAGCAACACCCAAACGCAGTACAGCATCGAGATCCAGAACGTGGATGTGTATGACGAGGGCCCGTACACCTGCTCGGTGCAGACAGACAACCACCCAAAGACCTCTAGGGTCCACCTCATTGTGCAAGTAATCTCCCAAAATTGTAGAGATTTCTTCAGATATCTCCATTAATGAAGGAAACAATTATCAGCCTCACCTGCATAGCAACGGGTAGACCAGAGCCTACAGTTACTTGGAGACACATCTCCCCCAAAGCGGTTGGCTTTGTGAGTGAAGACGAATACCTGGAAATTCAGGGCATCACCCGGAGCAGTCAGGGGACTACGAGTGCAGCGCCTCCAATGACGTGGCCGCGCCCGTGGTACGGAGAGTAAAGGTCACGGTGAACTATCCACCATACATTTCAGAAGCCAAGGGTAGGGTGTCCCCGTGGGACAAAAGGGGGACACTGCAGTGTGAAGCCTCAGCAGTCCCCTCAGCCAGAATTCCAGTGGTACAAGGATGACAAAAGACTGATTGAAGGAAAGAAAGGAGTGAAAGTGGAAAACAGACCTTTCCTCTCAAAACTCATCTTCTTCAATGTCTCTGAACATGACTATGGGAATTACACTTGCGTGGCCTCCAACAAGCTGGGCCACACCAATGCCAGCATCATGCTATTTGGCCCGGGCGCTGTCAGCGAGGTGAGCAACGGCACGTCGAGGAGGGCAGGCTGCGTCTGGCTGCTGCCTCTTCTGGTCTTGCACCTGCTCCTCAAATTTTGATGTGAGTGCCACTTCCCCACCCGGAAAGGCTGCCGCCACCACCACCAACACAACAGCACTGGCAACACCGACAGCAACCAATCAGATAGTACAAATGAAATTAGAAGAAACACAGCCTCATGGACAGAAATTTGAGGGAGGGGAACAAAGAATACTTTGGGGGAAAAGTTTCAGAAAGAAATTGAAAATTGCCTTGCAGATATTTAGGTACAACGATTTTCTTTCTTTTCCCAACGGGAAGAACGCAGCACACCCGGCTTGGACCCACTGCAAGCTGCTCGTGTGACCTCTCTGGTGCCAGTGTGGGCGAGGGCTCAGTTTCGCTTTGCCCACAGAGTGCCCCACGTGGAACATTCTGGAGCTGGCCATCCCAATTCAATCTGTCCATAGAGACGAACAGAGTGAGACCTTCCGGCCCAAGCGTGGCGCTGGGGCACTTTGGTAGACTGTGCCACCACGGTGTGTGTTGTGAAACGTGAAATAAAAAGACAGAGAAAGAAAGAAAAAGGAACAAGACGTCCGACAGCAACAACAATCCCACAAACAACAGTCACAAAAGATACCGTTAAACTTTTTTTTTTTTTTTTAATCATTTTACTACATGGACATCATGGATAACAAGGAGATTCTGATCTCATTATTAATTTTATTAATTATATTTTCTGATATGAGTCTAGAACTTAGTGCAAAAAACAAGACAAAACTAAAAAAATACAACTGAAAAGGGTGAAGAGAAGTATGTTTGTTAAACAGTAAAAATGAATAGTATACTTCTAAACTAGGTTTACAACTGGTGGACCAGACACCAGGCACTAATCGCCTGGTGAGGATTTGGCATTTATCCACCAAAAAAATACATCCGATTTAACCAACATCTCCACCAGCGCTACAGATTCCTCCCGACTGTGGCATCTCATGCAGACAATACTATGCTCTCTACACACTGTTTAGAAATGGAAAGGTGATCTGCACTGTATCTTGCGTTTGTTGGCTATGCTTTCTTTTGATGACATATATTATACAGTATATATATACATATATTTTTTTGTTAGAGTTCTAGCCATTTTTATTTCTCCGCAGGGTCCTTTCTCAGACATTATGCATGCTGTATATGGCGTTAGCTGTGTGTTGATCTTCTAAAAGATGATAGAGTTTACTGGTAAATTGTG 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(+,+*,-'*')&)+++()%),)*))*(#$#($),.-+(%$#)-)'$&$((&%)/%&+,/-/.-.&/1-+/1.*+$**$*+.0/-).-)-,,*',-+$%',)1+*/0111*1-/0/*#%./20.)#*.)+*%#/*.()330622/0/,-.0.'&.22032/01/(#)0-+$/,-/0+&"###,)%$&')$*'%&&"*0*$&)(-*.-0,+()*.3-,1((%&'##'%+-'$05./01)21,-2/2-3,.5/22023((*,0-/*+-0%21.$).130./1/44.0(1.0,)1/021*/1&.51211*&1-0-+*(-(.-)+%-(%/3+1.025//-/-$0/52023-53(/*25*.3541335102.,4-3631*0/)-0-500+.-(33-14)43-,-.&,2.,32-)-455360-,12)-&%+)(&*+&/+0/...**.-+,',#(,%,)0.03+/.*54+0+-)22,.1(-.*+-(),,.554+12.++.14.4-52255(./-%.41/1.1-0.2.0/(3-.500.20--2305/43-2.0,)/-54511.%+*-**'%+./)&-),/,.*4%)253+46,15-*&,/32)4661.)/26300*/43+//2./.021441022+$,+)5/0/5-415+%$0+....5542113.(-'0(0221+-4103(/,301+434)0$./013563,0)*01/-5331055/1,.1*-3060255601.)0'3/.).)(/-$&+.1/-2-23661.+4051-50/63,(,4234202.042/3-4013,-//.*24-/&$1&2.400+'4331(.)*+.'10./%5225+.4//0-(2..02/2555252**&%&/*3-+#+./&-($$&'%()$.1+,5.2,.2211,,144.+++.4+()%000144(.1/0**/+2505/'44-03//3+6221'/551222)134/.-406654-&,52/00.+0()21*.)'.,.3&2/6254,&,-+1116/20/102/35/065/606.0342-0*0+/+*0,.4.(120/-.0+5/45.34-2325/5613/1164446561-12/-15442550*1/6-41635324113263546325++1+2+2465415236.20562440.-+0)436.021/000100/*).0,-00-11.'0+/1)-&1-('($((*2-&++11-**.)+)''*(,.,12/,-***)%('-*0121,-1(1.-11/+$#-..-*-122..,$,-,,)'&&%&$//&11...$-/+++*&)+&*%,-+()++(*-,++%%*)(*,+,)*%%*'((+$$%,()**/,&+-/,/&)-)-).00,%*')'*+,,',+(+./+)&)'(%#(*++**))())(%,(')#)))&+-01+0'.111/1.*(')'#++-+/0.+10/1/,(.-+,++).)+-1----*'+*+/,0+$*1/,++1-1,+*.&'+,)/++$,)+**&+++(+.++,)&'''(%'%&+)&0-*+2//+,01'000,/).(+'**%0'.,'(**/+*$).0/&(++00-.00+,11+(+,+*&.+-&11)/),11-1/,*+-+&*$++%11+'&--01111112*-/&,*+**('*'$#%))+,.+322250,(440/%,//.4341/.0.**/4/10-4..$,-,.'$)+1.+('35/1/+1,.1+,.0,00,,)-0*-1.0,$#+,-%(+/(.)*0-,+%),.-.+-*(*.**(&$$1/.,,,0/'01-/)0..*10(.,110-.12'02.)($))+%,0/.*%0.+*01(&0*-/2,11)0120-.11,-)0110-/1,--.1-)-20/1*,),/--///$$*((),1010-*+1-/.,/%/0.+')-.0,0)-+(/..,1101-'.,-+-.&+.$,1,11.+01.0).,1(110/(10121/,+1--+.0-.2+.1210/0&&,/020,,,/+0/02-..---'/,-01..$0112/++,-200.$%#+.20-2,,+,+*.%00,1-,*(''+&-..,00.,+-,101.++%*01100)'$&(%(,*/'**+,&*,*.-../-,.-.+*/*++/+(*,(*,+),0.01-++,-0/1))-,**--+,.&,++,,0)&*,.--111+,0+.--,/*)0.1*,.+,0'&$$,/.0('&%)&*&%&+()*&+)&*)+++)+&+,+)++.*(*+00111&%,-00-00-/1,-*/1221,)&0.&/0/-/-+,'',0,2000+*0.*--1-#(**,11..,,+.+$%&-(*--./+.*1.%**'+*+/*00...%/1110*+**-(,*,,(+))*-#*.2+. @rCer/1413/25_1819_CCS ATGGGGGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + JI6KKDHBHFGFJHHJJFHEKK:JKGJJDFJJDJHJEAEKJIKAD1IKIIFJG>9JEHKKGKJIFJICGG:CGEAGFEG@J>JJIJIEIJJIEHBGJIKKFHJHJHJI=>F=IFKJJJFKK=JJJCKIJHCH>JKJKIFKKHKHKDHI6KFIEHIHAAHKAHKKJI?KKJ@@ICIFKK:IFKEJKIKKIFKKKJKJKJHKAKK5IBIJIKIKJKKKJJIKKIHIEJI4GIKKID6IJKIIKDJKAKIEKKHEJJIFKKK>KJK?KKKKKEKJK2J>B;EJGHIKJKKIFKIKJIJA:BEGJ:K;KJKIKKKJKKK@KKJJHKFIJHKKKIJIJJKJHKKK@GJGKGKJK@KKKFHJEKKGJJKEIHEEKKJIJIJJKJ=JKKB5IJDKKJ3IKKGGAIKKDHBJIJFJGKJIKKFKJKKGH@KCJ>KKGKKFJ=KJKCJGJHKEJ=KIEKKIBKKKJJJJJCHABFHKJKBE=BDHHGJJIKKKIKJI@KK?JKJKEHJFIJGH=HK?EJAD@A>IJDFKEKBJIAIJGKJJKKJ;KF;K=HJJAJBFG>KJIKJKICKKIJKJIKKGJKFJ?KJDGJHKKKKDGAB8AIJJKB4JHKIJKKDJJIJKIK9KFJIJBKIJJJKKJFJJKIKKK@KIK=HDJGJ6KJDKKIIHFKHBHGFAIIKKKDKKKKJHAKKJJJKK@KFHKIH>KFGIBIKDKKJJCJJKEJDKJHDIJKKJDKKIBHKFJCDJJKKKGKKKKJKJEKFKI2KKKJ@KKHHKKJKKKGKKIKIKKGKKICGIJ+KKKKKKKIBJGKK=KKKKK,KKKKKKKKKKKIIKKKIFEJIKHHKK)KKKKKIJKJKKKK9KKKBKJIIKKKJKKKKJK9JIK?HKKKKKJJ.KKKKGKKKGKKHHEFKHGKJKFKKJJKKKHKKKKCKKKFKKKKK@JI+JKKKKKG3KDJKJKKCKHK1JGCGJKKKDHKFJ;KKHKIIKGKDKIIAKKIIKDKKFGKJ(IKKIJKK>KKJGJ6KIJIGJJKKJKIKKKKHK1KKKJHHKJEF=KJIKKA@KJGJJKHKKKKFKAIJIJJKKIKKK>KKHKKKIEKKKKJEIBHKGKKIKKK==:2<9;9=<1>6=995=<6?=;<=:21;6;>?>85975:;39%<4>;<=886:1:=>=97:=9==>=*8<2783879:=;;55*;8352*396773,=:7133788397><92147<3<678771;:09694;:+77>?9725;82.962:99:6381129<:89:6:>;>985664=<71/52;98655736;>9647+9:9<=884<=38:7978=5?8:;=654<7223.687.28550-7106464875432+4:,88:75:2+95-14)26)50*424,41-7:8;375421$+,-///44749822&944::6:2321817458857769/7175888.476574&58:80860:66928899)88::::914;9:;;4725/775.697/.8)36:407432./(442614.507679355590066;78:812760.344932357911/786/178;7:3302-6621/,*1(&$4(6040,&083826.2056:55+555567::89;69684,.2397368)2;:56643,5)756.1,97;5:6.649745655140-,',,-,1105&6'196076751:6433/-$74599:3;594875825813561038141.8206::,/,:/732552401555742889%6:36286798665:49274.615697025-,14)6989.3924-8/,33$8833--4,1138468152&1648148-52/66355103/::538:.347-/+301(1,(73549+:95+399496:328:9+:8245.8480.987017-904/5928484084(2,+035564620+241254-6-51012)&(--.,343415611.1,3,*''),-1.53333'32'650114-/.5+623-453,332,(&)0+/+.0-,-.*15403/33/.0.1356356(0*/*/13563,045640/4,0,.'.422-210)2,4/-/,0),3(/03'55134465042*./5/32'03.5-4654,03143+56/0314110-11*/10&,5%)/&.$-/)100/540265656/352.$2-0)-0*/-5./345603102256345/4+),$03.4((52.1255)5051+-5,/0---)+$,,+-*4+-/2//*1424*414,3)0)215622*)/650+.1*520-(1()413/151/*03.1+454/15-,2056510#(*53)22.)%,.-&4,..5043)22&0*11+451,233504310+0552214361341*.5'4626/0/3-54005.141(*.(2562520/3,025+11,).0.,4).2%36.33/546-36,422*62/05503142/142(66034556-01.455143+---2*&,#*,4-.204442/-(+/(*452+4//,3*5232*004454%462640-..1442.5353124.-1551-04.01626653031'2104../64240-%106.1*140-&-10254.054-0054)452.041.353-02%-,/*54.+.20&-35+-30.553/1.*11)350/+,20262224.41/53,///023*011336434-13.645150/1-46./*)2105.).).1/%&21621,0252152))4316165202+/03-/+.*,+*.$-3 @rCer/1415/25_2433_CCS ATGGGACCGGACTTGGTCGCGCCCGAAGTGTAACACTTCTCTTTGTCGGAGGAGCTCCTCTGTTTCCTGTGCAGTAGCTCCCGTTGCGGCTGCACCCGTGCAGCCTGGCGGACGCAGGAGCGATGGCAGCGACCGATATAGCTCGCCAGTGGGTGAAGGTTGCCGAACTGTCCCCCTGGCTGGACATGTGGGGTTTGACAGCTTGCTGACCAGCTGGTGAATAAGTCCGTCAGCCAGGGCTTCTGCTTCAACATCCTGTGCGTGGGAGAGACAGTTTGGGCAAGTCCACCCTCATGGACACCTGTTCAACACCAAGTTCGAAGGGAGCCAGCCACCCACACACAGCCGGCGTCCAGCTCCAGTCTAATACCTATGACCTCCAAGAGAGCAACGTGAGGCTAAAGCTCACGATCGTTAGCACAGTTGGCTTTGGGGACCAGATCAACAAAGAGGACAGCTACAAGCCCATCGTGGAATTCATTGACGCACAATTCGAGGCCTACCTGCAGGAAGAGCTGAAGATCCGAAGAGTGCTGCACACCTACCATGACTCCCGGATCCATGTCTGCTTGTATTTCATTGCCCCACGGGTCATTCCCTGAAGTCTCTGGACCTAGTGACTATGAAGAAGCTGGACAGTAAGGTGAACATCATCCCATCATTGCCAAAGCAGATGCCATTTCGAAGAGTGAGCTAACGAAGTTCAAAATCAAAATCACCAGCGAGCTTGTCAGCAACGGAGTCCAGATCTATCAGTTTCCTACAGATGATGAGTCAGTAGCAGAGATCAATGGAACCATGAATGCCCACCTGCCGTTTGCTGTCATCGGCAGCACAGAAGAACTGAAGATAGGCAACAAGATGATGAGGGCGCGGCAGTATCCTTGGGGCACTGTGCAGGTTGAAAACGAGGCCCACTGCGACTTTGTGAAGCTGCGGGAGATGCTGATTCGGGTCAACATGGAGGATCTGCGGGAGCAGACCCACACCCGGCACTATGAGCTGTATCGCCGCTGTAAGCTGGAGGAGATGGGCTTCAAGGACACCGACCTGACAGCAAACCCTTCAGTTTACAGGAGACGTATGAGGCCAAAAGAAATGAGTTCCTAGGGGAACTCCAGAAAAAAGAAGAGGAGATGAGACAGATGTTCGTCCAGAGAGTCAAAGAGAAAGAAGCAGAGCTCAAAGAGGCAGAGAAAGAGCTGCACGAGAAGTTTGACCGTCTGAAGAAACTGCACCAGGACGAGAAGAAGAAACTGGAGGATAAGAAGAATCCCTGGATGATGAAGTGATGCTTTCAAGCAAAGAAAGACAGCAGCCGAGCTGCTCCAGTCCCAGGGCTCCCAGGCTGGAGGCTCACAGACTCTGAAGAGAGACAAAGAAGAAAAACTTTTTTTAATCTTGTCTTCAGCAGCTGCACTAAGTCTAAAGGAGAAGACTGCCATTATAGAAGAGTTAGGGTTCCATATTGTCTCAAATCAGAAATCAACCAATTCCCTCTCCCTCAACTGCAAGCACACACACATACGCCACACACCCAACAAGTGTTCATGTGTCCCTGTGTCCAGGCAAGAAGCTCTCTTCCCGACTCACATGGTATTTTAAATGGAAGTGTCTTGTCCTAACTAACAAGGCAGGAAAAGAACCATCAGAGCTGGAAAATGGACCAAATGTAACCTCAGAGAAACAACTACAGACCACTCACCCAAGTGTAAGTGACTGGGGCAGGACACTTCAGCTGTGGGTGTGGAAGTACTGTTCTGTTCACAAGGTTTTGTTTGCGTTTTGTGTTTTTCTTTTAAACATTTCTCTGGTTCGATGGGTTGACTGTCTACGGCCACTGTTAAATATTTCTGAATATGGAAGAGAAAGTCAAGTGACATTTTATCTTCTTCAGCATTTACAGACCTTCTATAGATTCCAGCAAAGGGAAAAATGTGTCCACTATCTAACACTCAGGTGAGAAGGGAGAGAAGGGAGAGAAGGGAGGGGGTTTAAGCTTAGTGAGGGCAAAATTACTCCATTCCACCTTCTGAGACCAGTTGGGGTTTTGAGAGAGGTTTCTGCTCAACCTGGGATCTGGAGGGAGAGCTTTGATGTTGGTAATCTGCCTTGAATTCATTGGTTTAACTTGCATCAAAATACCATGTGAGTGTGCTCATTCTCATAGATCCCTACCATCATCACCACCATTCTGCTGTTCAGTGTCTCTTGAGAGAGCCTCTTTGCATGTTTTCCAGAATCTGTGTGTGCTTTTCCTTTCTTCTCCTTTGTTCTTTTTGCTCAAAGGTGTGACCAGTCACTGCCCTCTGGGCTTCATTCTCCAGAGAAACATCCAGAACCAGCACTGTTTAGCTTACTACCTTTCTAATGTCCATGTCAATTTTCAATAAAATTCAAAGAAATGC 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rCer/1417/2571_60_CCS ATGGGTGTCCCTGAGCCCTCTAGTCCTGGTTTCCACTTTCTCCCCCACAGCCCGTGTTCCCAGCCGAACCAGCACTCTCTGGGAAGCCTGGGGTCCCTTCACACCTTGGCTTTTATGACCCAGATGGCTTCTGAAACAGGAAAGGAGAGAAGGAAGACAGAGGCCTGTGCCCACTGCTGTCCCATGTGTACCAAGAGCAGCAGGGCAGAATGGCCCTACCTCCAGCCTAGGTCAGAGCGGAGGACAGAGAACTCCCCTACAGCCCAGAGATGTGGTAGGGCTCAGAGAAAGCAGCTAGAGAAGCAGCTAGAGCACCTGGAGGAAAGGCAGTCAGCATTGACACCCTCTCTTAAAACACATTCCCGCTCGCCCACAGGCCTGAGGTCTGGGACCTTTCCCTCCTAGGAGTTCCCTAGGTGGCTGGAGGAGGCAGACTCACTGGCCATTTCCCTAGAGTCCAGCACACTGCAGGAGGCGTTCGGAGGAGGAGTTCCATCCCACCCTCTGCAGCCTTCCTCAAGCGCCTGTCTCTGGTCCCCAGCCTCAGTGCCTCCCGGCCCAGAGCCAAGCAGTCGTCGTTGCCAAAGGAGCAGTTAGGCTGCCTGCCTATGGGCTGGGAGACAGGGACAATGGGGAAAAGTTCAGGAGCAAAGTGAGAGTTGGAAGCAAAAAATAGGACCCCGCCTATTTAGGACGAGAATGAAGACTGACCCTTGAGGCACACTTGCACTGGAGATGGGTTTATTTCACACTCTGCTTGTGTGCTTACAGAGGGGGAGCTCAGCCTGGCTTCATCCAGAGACCCTGCCATGGCCCTCCCCCAGCCATGGGAAAGCAAACTTCATCCTCAGGTGTGCAGCCCAGGCCCTGCCCCGTTACGGTCTAGGCCGCCTGCCATGGGGTGCAGCCTCTCCAGGGGCTGGGCCAGACTTGCACGCTGCCCACATCCAGATTCCAGCGAAGATGAATTGGCTGCATAGCACCCAACCACATACACGAGGAAGAAGATGCGGTCAGCAGTCTCAGGCCAGCTTCTCTGTGACCCCTTTACTCCTCTGGGGGACTCTGTGGGGAGACATACAGGGAAAGGAGCTGTTCTTCAAGGTCCCCCCTACATGAGCAGAAGAGTGAACCACAGGGGTCATCAGCTTGTATCTCTCCCTTTCTTAGATTCTCAGCTGATGAAAATTTGGGTCTGGCCCATTTCAGGCCATCTTCAGTTAAAGAAAACACCCTCTTAGGCTGTGCAAGGTGTGGGTTATCAGGGGATTGAGGTCACCTGGGACGTCAGGGAGGCTAAGCTTGCTCCCTGCCCCCCAGACCTGTTTCTTCTAAGGGAGGAGGACATGGTGGAGACCAGGGATAGGAGAGCCAACAGGGTAGATGCAAGGAGCTTCTATGCACGCCTGAACCCCCCGCGCCATCACCCCAGCCCTAGGTATGCACCTAGGCCTCATTCCTTTACCCCCCAGCCCCAGAAAGGGGCCCCAGCCCCTGCCCACCTTCAGGATGAGGCCCTGGGTTGCCATGCTCTTGCTGTTCCCCTCTTGGGCTGGGCTGGGGCTGCTTTTTGGCCCCAAGGCTGCTCCGGGCCAGCAGCCCAGCCAGCAGTACAGTCTCCATGGTGCTGAGGAAGAGCAGCAGCAGCAGGATGGTGAAGTAGTAAACTGGGGGAGGCAGGGCACGGGGAGATGCTCAGGGGCCAGTCCCTCAGCAAGCTGAGCAGCAGTGGGTGACGGGGGAGAAACGGCAGGCTGGGTGAGGTAGCAGGGCTTACTGAGCAGTGGGTTGCAGGAGGAGGAGCTGGGCAGGGCCTGCACCAGGGAGGAGTGGAAGACGAGGTAGCCCAGCAGCAATGTCACCTTGTAGCCTATGCGCTCAATGGCCCGAGGGGCAGCAGCCCCCCGCACACGTCAGCCAGCAGCAGCGCCTCTGCAGGCACCAAGAGAGCGATGATGGACTTGAGTGCCGTGTTCTTCAGGCTCATCTGGAAGGGGAAAAGCCAGGGCCTTCCAGTGGGAGGAAGGAGGTGGGCAGTGGGGGCATGGGGCTTGGCCTCTGGCCCTGCATCCTCACCCCCACCCACCTCCAGCAGGCCTCTGTTGGCCTCCTCCCGACTTGACTCACCTTCACCCGGAAGCAGGGCACCAGCTGCTGGGGTGGGACTTGGCCTTCAGATCATAAACTACGTATTCCCTCTTGACACTCACAATCTCGTTCACCGCGTGGGTCTGGAACTCTAACTCCATCGCTGAGGGGTGGGAATGAGAACTATGAACTAGGAAGGAGAGATCCCAGCTGCCAAGTCTGGGGGTAGCAGACTGGAGCCCAGGGGTGATGGAGACTGTTGATGGCTTTTGGCAGGGACAGACTTGGAGACAAAACCAGTCCGTAGATGGGCTTCCCAAACCTTGTTTTGCAACATCCCAAATCGTCTCCAGTTAAAGGAAGGCCTTTATCAGATTCATAGATGAGCTTTCATTGTAAAAATAAATGTACTTTGCACCACTT 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/=;24(0+6<.<==68:2<:4+64;<85,78*=389;=<:47734'475<;9-9806+47/9:?8796?;1<;:<==8252=5<87.2;<9<7<:84=:8929;783?>6;=<76/78993::=>?8<7974/753<<;394'6,36972(623'79:;9773?5=8=:?=639<6==;7=;5840./*5?6=4;65:<6;9:=.6=:?852-)/-5443/816692*<88687/0254-44,2965837-92/06/9;;5243'12(28>9;:1/9:81:8:72911:+=664302:>9=7:;,22*166(/3854?5871883=142228:====732;1<9-0;;69-813/:/:<=6:<89>=>;?=<;5*50?::77=87:968088614.7:0.95777.32637:./-6+326.)20894873891..846:2677.42723949655007689:39497:4399::.489186599418*3,/-3/65571862265567226-2221455131732425566482%229556923,3::10-1,,(52:712143627-56:32346,255.4/7715/652--3,*54068:8:95356,37*.5;974,366492:6567444)357664/6481*973643655558410+5%02.1221*.01216082/86820/39416:4509.7794354:9556.21+4954451552632,10/4657*4221--8623&-5,513-11//51.686*154825646%/5*486+5&77587:88445.77551:2(50(315,55./22/1&546..285164036555020553935437998745+567-546552.377835421/4667//4.7442%2955::701.165/69357816493:4090//3(726592959667.577%5572:4448706204835021454+12655*3,+.+-3)*2&0'3-265520538412831635,,224367757356553684856753.20430675652&735922542863332%1:885786233302-464749;596.134695343960-1+86+/40/0+1*/6:9578548.3&2852-.-1/***+(+*$'*3661%*1-,2+0,-/'/-%34123(,*45:77943/46978&87135+0989-:816//.2(2040.16947:72,962776.*9636'6522265(54587;8;7,653++8-1(0358:2995535-7720,355%+3154661(381244464747664861576626*05.7.24/3-18/635539/96973%/524;84-1..//'1465931:537/77,76689;:5888114946859:8954332654155232-3435.+2468134,1303/4355,36847.4/-,*+215)0+.2.-)6/+/$178632%.054825030+232$(66*76796)7466,6638687;6831-97:94:;959167*1576575/661161845%649314$2,29243699453786406%69885,8693849:24612'353656553-3630.1)042.:8818533656666:645;56+546)4370865682:7565534521835+32227::55/655598176-.4:6-/*/226/530+0*-&+//.%%)27530,-.(12.7)744790930337436.'1126/992:6:267450682618::7:;:55;86.96613681:+04,-55;56365;858/554+503:7;89660559:9166859796823.6858368588/00.+.510:7::6:47(423793625/60*5:;647141&#',47,8862-045675,57783.347287871,0251(2455/20357933/62;585414:689937772-7.2595944424/-121/3;35:8864899;7899/339)88/218.8.;49957578677/974979:98;89:8::79322-19:90492999,160;6;;645722:8//55566-589-3:649:99:8:2537958;88.6.26346;485:945:5477;:;895:96861+0448:/3576:::8533775-695343,-7'347.746::620-4)7898558;:983237--.4247544;9285238-518.97348;37939695.-69:/89946792::779,:5:::1;8535795901568.983:56*:738:84611,/63155232)4/15723.7969:6822;6:7984459;559956627396367:7991699026/-69;43:99839384.556989*::872:395:789992:;4995;9777969895.879+92189466)75845:3808948:0:153:4;8:73:86366602555::939:887/5.:5/478:7(075+9327976576099187+ @rCer/1418/25_1810_CCS ATGGGGGGCGCCGGGAGACTGGGACAGGAAAGACGGAGGGACAGGGAGAGATGGAGACGGAGACGGAGACAGAGAGAGGGGTATTGGAGACAGAGAGAGAGAAAGAAAAATAAAGAGAGTTAAGAGACTGAGCGCGATAGAGAAAGGGAAACTTGAGAGAGGCAGAAGGAGATGGAGAGAAGAGAGAGGGAGATGGGGGTGCCCGTGAACACCGGGAGAGAATCTGGCATGGAGTTTTAGAAGGGATAGACGTGGAAAGGTGGAAAGGGATTAGGAGAGGTCTCCTTCTGAGCCCAGAGAGTGGACACAAAGTGGAGGGACCTTCAGAGAGACCCCTGAGAGGGACAAAGATGGGAGGGACTGAGACAGAGGCCCTCAGGGAGTCTGAAAGGGACCGCAGCAGGGGCGGATGGATGAGAAGTCCTGAGGATCAGGAGACAAGGACAGCACAGGGCTGCAGCAGAAGAGACACCGCGTTAGCTACAGAGTGCTGGGAGGCAGGAAGGAGGTGCCAGTGTCCTCAGCCTGGGGGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCACCGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTGGAGGAGGACGAGCGCTTCGAGGGCCGCGTGGTGTGGAACGGCAGCCGGGGCACCAAGGACCTGCAGGATCTGTCTATCTTCATCACCAACGTCACCTACAACCACTCGGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTATGAGCACAACACCAGCGTTGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATCGTCGTGTTGACCATATGGCTCGTGGCAGAGATGGTTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAAGAGAACGCCTCGGAATACCTGGCCATCACCTCCGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCCAGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCCTAATGGGGACTCTCCAGGCACCGCCTGCGCCCAGTGTGGGGGTGGCCACTCCTGGGCCCCGGAAAGCCTGAGTCCTGCCGACGGAGCCGCTGGGGTGGGAGGGGCAGGGGGATTGGCTCGCACCCCGCCTTGGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGCAATACTGCCGCTGCCCCCACCCTGCTTCTGCTGCCTGTTTGGGGAGGGGGGCGGTGAGGTGGGGGCAGCGGCCCCGCACCCCTCCTCCTTGCTGATTTGCACACATTGGCCGCTTCAGACATGCACTTCTGGGGCCAGCCCCTCCCCGCCTCCTCCCTGCCCGGCGGCAGGGATCGCGATGATGGGCTGGAGCAGTCTGGGGCAGGGGGTTCTGGGACCCACTCCGACTCCCCTTCCCCGGCATCATTTCCTCTCCCGCTTCCTCCGGCTGGACCTGGGGTCCCCCCTCCCTGTAATGCACTCCTGCCCCGGCCCAACCTCGCCCTCTCTCACCAGCCTTGAACTGTGGCCACCTAGAAAGGGGCCCTTTCAGCCTCGTCTCTCTTTACAGAAGTAGTTTTGTTCATGAAATAAAGACTCTTGGACT 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@rCer/1419/1858_56_CCS ATGGGTGTTCATATGGAATGGTGAGGTGTCACCCAACCTCTTTGAAGAAATTGACAAGGATGGCAACGGAAGAAGTCCTCCTGGAAGAGTTCTCAGAGTACATTCACGCCCAGGTGGCATCTGGCAAAGGGAAACTCGCTCCTGGCTTTGATGCTGAGCTGGTTGTGAAGAATATGTTCACCAACCAGGACCGGAATGGAGATGGGAAGGTCACGGCCGAGGAATTTAAACTCAAAGACCAGGAAGCCAAACACGATGAACTCTAAACCTGGCACGAACCAGATGGTGTCAGGGAGTACGTGACACCAAGCCACTTGTCGTGGCAGAGCGTGTAGTGAGGGTGCAAGGGTCTTTCAGAAGGTGCATCATTAGCCAGTAGTAGGTGGGTCACATAGTACCTGGTGTACACATCGGGGTGGGTTGATACATGGGGTGAGAAGTTTAGGCCGATTGCCAGTGATAGTAAACAAAATCTTTGCAGAGAGCCTTAGCACGGGATGTGTCCAGTATTGAAAAGGCTGCACTGCCAACCATGATTTGTGAGCCTTCTGGGAAATTTTGTTATTAAAGGAATATAGTGTCAGATGGAAGTTATCATCTTGGAGGAACCATAAGAAAAGGTGTCCAGGGTATCTATATAAAGAGGGTTAAATTTTTTTTAACTTGCTGGTTAAGACATTTTAGAAATATTCTTGAGATGGGCAGGAGAGTCAAAGGGCTTGCTTGCCCCAGCAGGGTTCCCAGCAGACAGCCATGGCTCTTCCCAGCAGCCTGTGCAAACTCTGATCATGGCCCACCCCGGCACACGCACACGCACATCATGCTTTTCCAGCTCATCACACCCTGCCCCACTGTGGGCTTCCCGTTAATAGTGTATAACTTGGAGTTAAGTTAAAAGAGCCTTTTGGACAGAAAACTGGGCCAGGAAAAGGCATCTCGGACCACAAATAGAGAATTGATTCCGCGTTTGCCACATAAGGTCATCTGCTTAGCTTTTTCTTTCTTTCTTTTTTTTTTTTTGGAGACAGAGTCTCGCTTTGTCGCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTGACTGCAGAACCATCTTGGCTCACTGCAGCCTCCGCCTCCCGTATTCGAGTGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGCACTACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATTTGGCCAGGATGGTCTCGATCTCTTGACCTTGTGATCTGCCCACCTCAGCCTCTCAAAGTGCTGGGATTACAGGCGTGAACCACCGTGCCCAGCCACTTAGCTTTTTCTTATTCCCACCTTTCTATCCCATAGAACACCCTTTTTTATCCTCCCTGAACCATATTGATAAGATAAATAGGGCTGGGGGCGGGGCCCCGCTGGTCACTCAACAGAGTATTTCCCTTGGCCGAGATGGAAGTTTCGTCCCAATAGATGAGCTGCTGAGCATCAACAAGGTGACATTTTTCTGCTGCCCATTTGTGTCCTGGAGAGGGTGGTACCCTGAAGGCAGAGGCCAGCTGCTATAAGACAGCAATGACAGTCCACCTGCCGGCCTGATTCCTGCATCATGGAATAACCACGTGGCTACCTTCTATCCTCTGTTCCCAAATGGTGGTGGCACTTATCCTGAAGTCGTCAATGATTTCCCTTTGAAACTACTTTATTTTACTAATTTAAACTATTTTGTACTGATGTAGCCCTGAGGTAGTTCATGAAAATGCTGTGCACTCATTCAATGGAATAAATGTTGGAAAG 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6:=:6:<;:99968;8=*7;4=<5<8;8=77;:6=5=<8;<=7=;>9=91<05,37)/0:3<5<<6=7=4//:6>;==0<:6?:=9:85:6:3278;;956;=;><:<:;45744:444519719==49;6==7=8;:7890;?=<;=7;;53834868/68>79<9;3:<4:7<7;85587:(=89<4;0688=18<5<<69<807*966167::;758023%98-;:+-8/:=-<<8*9<6996=97:586;5347;4<::8:<8=9878<<=<)>6=<>:=7/*397<=>99:97:6826?99;9821<>==2::69>:748=68:38<=067<===<7;89:+=<=:7;67:<125=<:>;<6886<:45=965<1$5<>:<<<99836>7;69<6:8;8<:51-497.8,=<8:=3:<784612;808=9/<;:;99=8;:396;7><=?:<<;;99/1:>::9446=:-=:;9639=3572<6;4>3:.7<3==99:;=<8;=8?4894>;;/6850>95415-9(./5(999<9=987<620==7;:6:;93/76:<9:;949;<6=9;:5>9:<=;;4685<8;8?61<2=@-?=>?<=2??6=??@ABA&A?>=+=?8<:=>=96<=@A@<9><>@4A<@><@;@B<8@=?;===2=;@@A=9;@<<@=8@9=>2B@<48;@98>8BAC====@4>:&?@<@;B77::@-<<=;1<9?7?C5AA=@CCA0:-?8><6=<@A?B?:AB>3>@B;@@A>/@2A=:=@;=:>B?A?8AA@>=':8<@=@B49<19<,9@.@;>?;436/:>;BABB8@>@;?4=>.6??,@<5C><;?&C?CAA=@>@:@==<-B:=@:@?>/;8B>>=;=::A=>7@>A99<=:?<99':;A=A>9=;4;A?;=:<=6><89@8AB7@<79>?A)=>>:;;7.4=?=>=@@>;<@@*@;>>@6>796<<:5:;:>*AAAAC6>B:><;=7;A;:7A@C>>@A7>;79@B;@A@=B@:;9@B:C==7B?BB@:A><<<=BA;47<<@<>A:B@9>17>8@>@>;==@710&+37/6/5:A;?>A;=<.=@?=?8>B@=3>>8>ACC2>>?@<8.66=?,@A>,;=A2A?@5?:;?;=0<9>=9+<9A?<;=>CAC?@>6?@A>?/9C;B@@::;*5:2@;>@7@@7<<:7+<8=><<8AA?2:@?4;>5>=>96?=>-<952@:@@0@A;C?8;@A>CC:@>@C?>A@CAC=<:B@@89589;2?8?;>@/>A6@;;?<>;*=9;<.;@@A@A*?A<::C?B3;==@=7A=96@>97:81?;-6-B;A:1><7==876B:<<:AB>==293698A@B?:B=)<574;A=>.>64@;;==C?;><<>:=@:9>9=>:=6:?AB@8>7?;;6@@=>A?@A@==:2:=:9:=B669A=:<@<7?>?3=<>7?;<0<=A<879,6@8>=2<17=6:9=+?;;:5>:B=A>5<===8:<6:569:39628;77:7<>=?6;=:72<;?5;<=6759;14 @rCer/1423/25_3504_CCS ATGGGAGCCCGTCGGTTCCCGAGCGCCTTCCCGGTGACCCCGCAGTGGGTGTGTGAGGGGAGGACGGACAGACCCACCAGACGCCGCCGGACCAGGAGGACGCTGACGAGGCACCATGCGTTGAGATCGTGCACATCCAGGCGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTTTGGGAGAGGTCATCAGTGTATGAACATGGGATTGACCCCACTGGCAGTTACCATGGAGACAGTGATTTGCAGCTGGAGAGAATCAATGTTTACTACAACGAAGCCACTGGTAACAAATAGTTCCGCGGGCCATCCTTGTGGAATCTGGAGCAGGCACGATGGATTCGGTTAGGTCTGGACCATTCGGCCAGATCTTCAGACCAGACAATTTCGTGTTTGGCCAGAGCGGAGCTGGGGAATAACTGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGACGTGGTGAGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTCGGGGGCGGCACGGGTCCGGGATGGCACCCTGCTCACAGCAAGATCCGGGAAGAGTACCCAGACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTGGAGCCCTACAACGCCACCCTCTCTGTCCACCAGCTGGTGGAAAACACAGATGAAACCTACTGCATCGATAATGAAGCCCTGTACGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTGCGCTTCCCGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAAACATGGTGCCCTTCCCGCGCCTGCACTTCTTCATGCCCGCGCCCTCACCAGCCGGGGCAGCCAGCAGTACCGCGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATGGCCGCCTGCGACCCGCACCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTACTTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCGGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCTGAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAGGGGGAGTTCGAGGAGGAGGGCGAGGACGAGGCGTAGGTGCCCCGCGAGGCGGAGGCGGGTTAGGGGAAGCGGAGGAGGAAAGCGAGGGGGTGGGGGCTTCCCGGGACGGTACCCTGGCAGTCGAAGGAAAGAAGCATGGTCTACTTTAGGTGTGCGCTGGGTCTCTGGTGCTCTTCACTGTTGCCTGTCACTTTTTTTCCCTTTTTTGTAATATTGATGACATCAATGTAACATTTGAGATATTTCTGAATTACTGTTGTAATGGCTAAAATCACATAAACGTTTGTGTCGGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTACTCTGCGTTGATACCACTGCTTAAGCAGTGGTATCAACGCAGAGTACATGGGGGCAGAGCGCGGGAGGCGGCGGCGGCGCGGAGGCCCAGGTGGCTCCGCTGCCGGATGGGAGTGTCCCAGTGTGCTGGATGAAGCTGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCCAGCAGCAACCGGGCCGCCCCCAGGATGAGCTGCGGGGCAGGGGCAAGCAGCAGCAGCCAAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAGGTCCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGAGCGGTCCCAGGGTGGACTGGCAGCCGCGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCATCCCTGCCCTACTCGCCCGTCGGCTCCCCTCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCCTGAAGGATGAAATTGGAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAAGAAGCTGATCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAAACCGCTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTTCAAGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTTCATGGCGCCCGAGTCGCTCTCCGAGACCCGCAAGATCTTCTCTGGGAAGGCCTTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAACCAACCAGGAATGTGAGTCCCTGTCTGAGCTCAAGGGG 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@rCer/1424/1727_60_CCS ATGGGGGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACGCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACAGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAACGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTG + JKKKKKAKKKKKKKKKKKKHKKKFKKKKKKKKJKKKKKKKJKKKKKKKKKKKKKKKKKKKKJKJKKKKKKKKKKKKKJKIKKKKKKKKDKKKKKJKEKKJKKKKAKKKKK?KKKJJKKJJKKKKKKBJKKKKKKKKKKJKKKKKKKKJKKKKKKJJKKKKKKKKKKBKKKKKKKJKKKKKKKKKKKKKKKKKKKKIKJKKKKKK?HKKKKKKKKKKJKKKKKKIKKKKKKKKKKKKKAKJKKKKKKKKKKKKKKKKKKJKKIKKK3KJKKKKKKKDKKKKKKKEK>KKKKKKKKKKKKHKKKKKKKDKKKKKKJKKKKKKKKKKKKKKKJKKKKKKKGKKKKKKKKKKKKKKKKKKJKKKKKKKKKKJKKKKKAKKKKKKKKKKKKKKKGKKKKKJKKKKKKKKKKKKKKKKK8KKKKKKKKKKKJKKKKKKKK8KKKKKKKKKKKKKKKK:KKKKKKKKKJKHKKKKKKKJKKKKKDKKKIKJKKKKDKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKJKKKKK:KJKKKIKKGKKKKKJKKKKAKKKIKJJKKKKKKKKKKKBKKKKKJKEKKKKKKKKKKKKKKKGKKKKKKKIKKJKKJKKJKFKKKKKKKKKKKKKIKKFKKKKIKKKKKKKKK8KKIKKKKKKKIAKKKKKIKKKKKKKKKKKKKHHKJKKKKGKJKKKKKJKKKK@KKKKJHKEKKKKKKKKKK2KKKIKKFK5KKKKBKKKHKKKKIKGKJKKKKKKKKKJKKK2JKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKKKKKEKKKDKKKKKKKKKKKKKKDKKKKKKKKKKIKKKKKJKKKJKKKKKKKKKKKKKKKKKJJKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKHKKHKIKKJKKKKKKIKKKKJKKKGKKKKKIKCKKKKKKKKKKKKKKHKKKKKKKKKKBKKKKKKKKKKKKKKKKKKKKKHKKFKKKKKKKKKKKKKKKKJKKDKKAJKKKKEKKKIKKKKK;KKKEKKKKKKKKIKKKKKKIKKKKKKKJKKKKGKKCKKKHKGKKKKKKKKKKIKKKKKKKKKKKJKKKKKKHJKKKKKKKKKKKKKIKKKKKIKKKHKKCKKKKKHKKKKKKKKKKKKKKDKKKKGKKKKKKJKKKKAGKKKK@KKKKKKKCIKKKKKKKKKJJKKKGKKKKKKKKKFKKKKKKJKKKKK@KHKKKKKKKKKKKKKKKKK?KKKKIKKKKJKKKKKKKKKEKKKKKKKKKKKKJKJKKKCKKKKJKKIJKKKKIKKKIDKKKHKKKKKKKKK0KKKKJKKKKKKKKKKKKKKDKKKGKKKKKKKKKKHKKKKKKCKKFKKKKKKKKKKHJKKJ9IKK@KKKKKKKKKKKKKKKKKJKKKKKKKJCKKJKDKKHKKKKKKKKJKKKK @rCer/1426/0_56_CCS CTGTTCTCCTGTTGATTGGTCTGGCATTTCCGGTATTAAAATGATACAATAAATGG + S)+%)%%(.03/42,).)21-5+615-54'1.3,2-0$+32121232$)(,//518 @rCer/1428/2217_57_CCS ATGGGGAGTGCCGCCGCGCCCGGCCTCCCGCACGCGCCGCAGGTAGCGCCCCCGCCAGCGGCCCAGGGTGCGCTCGCGCCGGTGCCAGCTCCCGGAGAAACGGCGCGCCGCGCGGAGATGACAGCCGAGGAGATGAAGGCGGCCGAGAGCGGGGCGCAGTCGGCGCCGCTGCCCATTGAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGGACCGAGTCTTTGTCCACTATACTGGCTGGCTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCAACCATGAAGGTGGGGGAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCAAAGATTCCCCCCAGTGCCACGCTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACAGAAGAGGAAGATGGCGGAATCATTCGCAGAATACGGACTCGCGGTGAAGGCTATGCTAAGCCCAATGAGGGCGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGACCAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATTGTGTACCTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCCGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAGATGAATTCAGAGAGAAGTTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACGGTGTACTTCAAGGAAGGCAAATACAAGCAAGCTTTACTACAGTATAAGAAGATTGTGTCCTGGCTGGAGTATGAGTCTAGTTTTTCCAGTGAGGAAGCACAGAAGGCACAGGCCCTTCGACTGGCCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCCGCGGCCATCGAAAGCTGTAACAAGGCCCTAGAATTGGACAGCAACAATGAGAAGGGCCTCTTCCGCCGGGGAGAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGGCTGATTTCCAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCAGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGGCCAAGGCAGAGGCCTCCTCAGGAGACCACCCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCCTCTCCACCAGCCCTACTCCTGCGGCTGCCTGCCCCCAGTCTCCCCCTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTGAGTGAATTAGACCTTTATTTTCTATCTGGTTGGATGGTGGCTTTAGGGGGAAGGGGGAAAGGAGTAGGCTGGGGGATTGAGGTGGGGAATCATTTAGCTGGTGTCACCCCCTCTTCCCTTCCCCTTTGCACATGAACATATGTCCATCCATACATATTCATCAGAATGTTAATTTATTTGCTCCCTCTGTTAGGTCCATTTTCCAAGGGTAGAAGAGGCAAGTGGTAGGGATGGGGTCTGATATGAACCCAGGGTGGAGAGGGAGACTCCTGGGCAGCCGTTTTCCTCATCCTTTCCCTTCCCAGTCCATTTCCAAACGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCCATTTCTTCTCTGTTCCCTTCCTCACCCCAACGGTGTGGCTGATGTCTTCTGGTGTGATGGTGACCACCCCTTGCTCCCTGTTCTGGTATTTCCCCTGTCAGTTTCCCCTCTCAGCCAGGTTGTGTCCCGAAATCCCCTCAGCCTCTTTTCCGCACGTTGCTGAAGGTCCAGGCTTGCCTCAAGTTCCGTGCTTGAGCAATAAAGTGGAAAC + JJKKK3GHKKKKKKKKKJKK3KEIJKFKHKKKKHEEJ;KKKIGFKKKJGKKK+KKIIKKKIKK0CKK==JKJK8HKIJKKKF?KKJHKKKKI1KKKKKJ)KI7KJJKKKKKKKKDIJIJKJKJJKHKJKFHKKKJKAKFKKJKDKKJGJKKKKJKKKKKKHKHKKKKKKKKKK3KKKKJKK8KKKKFKKKGJGJKKK/=K0KJKJJJJK9KJKKGKKGKKIKKHKGJKK+KKHKJJKKBJEKKKKEHFDKJJKKKKKEKKJKK.KKKFKK@KBIKKKJFIDK0ICAB=JKKKJKKKJHEEKFAHKKKCKJKKK1KKKBKDKKKBDKKIHKGKDKKJK@KKKKKKAK5KJKIKKEKKKJHKK>KKK?KKJ7GKBIK@IKKJK7KK;KKJKIJKKKGK6KJEK:KKKKHK6JGJKJGKKJKKKE@HK8KHJJGIKKKKHIKK4KKKKJKKHKKKKJKKKHIFJKIKFKKKKFKHKEJKADEHGGKKDKCIKGJJJHKKKBKKKCJKKKKHJKKFK@KKKK@KKKGKJKJKKHKKHK7ACKIKJIKKJJJKKKHKGJKKKIKDKFKKGKK@KHKKJKEKKKKKKK>FIKKAKIDJKIKHK8KEIKGJJJIIKJKJKCKKKI?IKIDKJKKKJ-6#KJKKKKBKKFKJKJKKK7KKEKBJK@JKKAJKJKK?KKKJKKKKHJKKAK@KKK9KGDHIK>JJK4KIKKKJ,KKKK8JHK;K9KA.=FHKAKK4FJDJIKJKKKIJ1HHJH>JKEK9KIKKJKKKKKFFJKKFKKKKKKKKIKGKKKKKKJKJKIKKJKIKJIJJKJEJJJKKKKK,KKJKEKJKKKGEIKHJKKKKIKDKKKK=KKHKKKKKK2KJKH5DKJK2I3KGJKDKKK@KKFAFKKKBKK,K@HKKBKJKKGKKK@CJJKKKK=KKKKKGK=FKKJ8KKIKIK2JKJKKKJGDJKJFKKKKKK8K7IKKKKJHKHJKIIKKGKIEKKK9K?EJ>HKK>KKAFKHICJHKJ@JKFIJFKKG5IIKKHEJJJ=FK3FKJ9KK>KJKKBKKCJI7FJKKJK3KABI=>CJ-KJKJKHIGKJKIKJKKHHA66J>KK.KIK;K>KJJGKGK/K2KIK5F9>HCHEB>KFHDHEI4KJKKFFHKKJKFGEKKKIIIK1KKKK-HFJKEDKEAFKIEIKHIK;HHKKJKHHKFIKJKKKAIJJ>9KJJJ*EK>HKK6JKKJJGKKE)<;JJJK4EJJHJKI%K@GHHJK;KI/9JHKK*KEKKKK2KKKHJKDJKKJJG=:D@9JKK;JJDGKI@KKKK1KDDFKEKIHGHK?JJG??I>IKJJJKJKK2K?KKJKFIBK(A@CI@GIKK>I?J@IKHHJ=;9KFBE>KJAKECGJJ=BHKK)KHKI;KJ7HKJ>>9KIJJKJ,KKK:KJKKJIKK>KKK4GKJI@KKIIKIKFEGFEKKHCKK5IKKK1IKKKKE8JKKK0KFKKKKKKEHIEKK2KICKHIKBIKFJKGJKKIKKEKJIJKHK5KKKKJI9KKBICKFKJ9K @rCer/1432/1967_61_CCS ATGGGGAGTACCGGCCCGTTGGCGACGCTGTCCCCGCTGTTCCGCCTGAGGCGAGTGACGCTGGCCGCCAACGAGGTATACGTCCTGGGTCCCTCGCCCTCAGTCTCGTCTCCGGCGCGGCTGCTCGCCCCGTTTTCCCTCTGAGCTGACCTGCTCCGAGCCGTGGGCCGCCCATGGCGGGGGCCGCTCCGACCACGGCCTTCGGGCAGGCGGTGATCGGCCCTCCGGGCTCAGGGAAGACCACGTACTGTCTGGGCATGAGTGAGTTCCTGCGCGCGCTGGGCCGGCGCGTGGCCGTGGTGAACCTGGACCCGGCCAACGAGGGGCTGCCGTACGAGTGTGCCGTGGACGTAGGCGAACTGGTGGGGCTGGGCGACGTGATGGACGCGCTGCGCCTGGGTCCCAACGGCGGACTGCTCTACTGGCATGGAGTACCTGGAAGCCAACCTGGACTGGCTGCGTGCCAAGCTGGACCCCCTCCGCGGCCACTACTTCCTCTTCGACTGCCCGGGACAGGTGGAGCTCTGCACGCATCACGGCGCCCTGCGCAGCATCTTCTCCCAAATGGCGCAGTGGGACCTCAGGCTGACTGCCGTCCACCTGGTGGATTCTCACTACTGCACAGACCCTTGCCAAGTTCATTTCAGTACTGTGTACCTCCCTGGCCACCATGCTGCACGTGGAGCTGCCCCACATCAACCTCCTTTCCAAGATGGACCTCATTGAGCATTATGGGAAGCTGGCCTTCAACCTGGACTACTACACAGAGGTTCTGGACCTCTCCTACCTGCTTGACCACCTGGCTTCTGACCCTTTCTTCCGCCACTACCGCCAGCTCAATGAGAAGCTAGTGCAACTCAATCGAAGACTATAGCCTGGTGTCCTTTATCCCTCTGAACATCCAGGACAAGGAGAGCATCCAGCGAGTCCTGCAGGCTGTAGATAAAGCCAATGGATACTGTTTCGGAGCCCAAGAGCAGCGAAGCCTAGAGGCCATGATGTCTGCCGCAATGGGAGCCGACTTCCATTTCTCTTCCACACTGGGCATCCAGGAGAAGTACCTGGCACCCTCGAACCAGTCAGTGGAGCAGGAAGCCATGCAGCTATAGCAACAAGGTGGATCCTGGAGAGCAGGATGCATAACCCAGCACTGGGGAAAGTGGAGGCTCCTGAAGCAGGCTGCAGACCCAAGAGCAAGTCCTCCCAGCGAGAGCTGGTGGGCTGGCAAGGGGATATTGAGCTCTGCAAAGGACTTCTGGCCAAAAAAGCCAGACATGGCGCCAAGCAGAACACCTACCATACTGTCAGTGGTGTCTGTGAGCTCCGGGCCCTGCCACCAGAAAGTCGAGCACTGGTCCTACTCAGGCTGTGACGGAATGTGCTGCAATACAAGAGTTTATATTCTACTTTTTGTGACTTCCAAACTCTTCTTCAGTCTTTCCGGGCCCAGGGGTTTGGGGAAGAATGAGGGAGTGTCACCTTCCCTTGGAATAATCAGTATTTCCCCAAAGCATATAATTCACATTCAGTCACATAGGATTGACATTCAGTCTCTAGTCAGGTGTTTCTATTAATCTTCAGTTTTTGGTTCTCAGGTTTGTTTGTTATTTTAAAAAGATGAGGTCTCGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGATTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAGTTAGCCAGGTGTGTGGTAGGCGCCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCT + 75989-2==9=7908=6>?;7::>>=?=>=7?=?8>>>5<4?:6=;45:8567367;968>8<9?9=9671;64><62829:;687<;95:<0=>59857679:92483014-41.)*;48A=95:;;<>7<=A=6>88;99=05?9=:3'065181;A736;9=8)6173,.32<0=:?;7'70==9<'54>-24+78146:<588<7/%;4:A/5)4)5?28A78800976:64=9:;&;@A23<>?;=A805=<99@7::@-B;=2>306<88@7CAC?>>@5:=@8>65@+B?;73-/>67:9:899427445.-0-31421=87989:5842=:*53699<<>=09-1-+03746>11:8:3;8,8789245436;-784.8(<869;/2'342-/),=3,'8=;<)16:;>=?>972.6142;32<13<1=4873:09689>>99/370>>=5.6:1=9?-?>@::?<@>B:6=>.B@A>=A?A1>@:5>A58;@89A89>>>?;ACC@>?6==31>;:;=><7897>;>A>=A=>A2?>5=A>@A?@;@9966<26>6./?=55054766:B>68;68<6;7:=3>;;<;:;1=1:>-==6&185:56-,59/89<;?68=>:9:<9>@<>?3@A7>2<;<301:>?AB?:=>9=8597.:;3+<6>B>=:085?;>7A>7<877;<;5;;=45@7:5C?1A39B@5:>@>@;>AA?;=;;?:948?<086=894.;@>A8B<;78;97-=8@3+79869<>8B?<<+;<6:/.77=6<;:5)<895';5><<;>=A:3<8891@4B>@8=AB8<9=A@>A?@BA@A=3=A7>>C7>A>==7568>AB<=7:)@>2A5@CB?B@B7A><8@;7?;<=1C:@4A83<58=B?9:7B@A<>.5:;426>73C@=6<.::0<1C<=>:;;.9<>;<>9/4BC?=B8:1:,8=;;5>C@A>086=;:9=944B<99=>=9><;7?4==C:;CC@B=AA;?57B=;<<8A;><8@;?<5:=-5@7;<::;@>@87>;06;A=:3:468406-4505>>?<=8936346;34039:679;644:&=A=;?<9>:8(??;6:6;8::<6:59957=3-799;::=?9955<377=<@@9=8)3*==';9-==A4BB>93@>5@>A90A:137<;>@:7?>40;;:9172:4=<8>:??B3=:<86A=:6:92*11;86AA=<=?A@&<<<7A@6><<@.>:>@7?>'?:?497;(::=<99?0=CC@6;;/>=6.=38>6<<5<7/05=;49><1:6==3?=?:<14;635742::=9<>83970=7;565:96/9669>=7189>46?>,'<4::6;492855=:970325851((46;58/9<811>95>=<2<:;9:-:7=;:>2<;804=8(+73%;956)73,10;8=>;/:86<=90>91=15;8<:<>:==><<<9:<>;7:><9;7=8?989?4;852<75992>89=7567519;86996253>=>>9964,8958=760=66::::6;;;6:836683/3278-5464(34&1564$692>4-&46762(6<<<865,/1852====>=995<::;>>286*;>3><3387;75;>;=6:>7<6:><87<-3;6>?9>?57><<78<>9:;:=>9:;>8>9:=/;;;>7::=<5<5=<>79-7.;66<9;3>=9=993989=;5< @rCer/1433/25_2217_CCS ATGGGGGCCCGGTAATGTTTTGGCCGCTTCAAGATGGCGGTGCAGGAGTCGGCGGCTCAGTTGTCCATGACCCTGAAGGTCCAGGAGTACCCGACCCTCAAGGTGCCCTACGAGACACTGAACAAACGCTTTCGCGCCGCTCAGAAAAACATTGACCGGGAGACGAGCCACGTCACCATGGTGGTGGCCGAGCTGGAGAAGACACTAAGCGGCTGCCCCGCCGTGGACTCCGTGGTCAGCCTGCTGGACGGCGTGGTGGAGAAGCTCAGCGTCCTCAAGAGGAAGGCGGTGGAGTCCATCCAGGCCGAGGACGAGAGCGCCAAGCTGTGCAAGCGCCGGATCGAGCACCTCAAAGAGCACAGCAGCGACCAGCCCGCGGCGGCCAGCGTGTGGAAGAGGAAGCGCATGGACCGCATGATGGTGGAGCACCTGCTGCGCTGCGGCTACTACAACACGGCCGTCAAGCTGGCACGCCAGAGCGGCATCGAGGACCTAGTGAATATTGAGATGTTCCTGACGGCCAAAGAGGTGGAGGAGTCCCTGGAGAGGCGTGAGACGGCCACCTGCCTGGCCTGGTGCCATGACAACAAGTCCCGGCTGCGGAAGATGAAGAGCTGCCTGGAGTTCAGCCTCAGAATCCAGGAGTTCATTGAACTCATCCGGCAGAATAAGAGACTGGACGCCGTGAGACACGCGAGAAAGCACTTCAGCCAAGCAGAAGGGAGCCAGCTGGACGAGGTGCGCCAGGCCATGGGCATGCTGGCCTTCCCGCCCGACACGCACATCTCCCCGTACAAGGACCTCCTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACAACTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCACAGTGCTACAAAGAGGACGGCAGCTCCAAGAGCCCCGACTGCCCCGTGTGCAGCCGCTCCCTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCAACTCCCGCCTGGTCTGCAAGATCTCCGGCGACGTGATGAACGAGAACAACCCGCCCATGATGCTGCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTTTGCCCAAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTATACATCATGTAGGCCCCACGTCGCCAAGCGCACGCCTCGGGGACGGGCTGCAGCGGGCGGGGAGGCCGCGCCTTCCTCCTGCCTCGCGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGACCAAAGATGAGTGAGCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACAGCATTTTGATTGGTAGGATTTTGTAACACGTCAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTTCGAAGGAAACTTTTCTTTAAAGACTGACCTAAACACTGAGGGAAACTTTAGAACGTTTAAAATATAGGAGTCCATGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAACGGGCTGGTCCTTCACCACCTCCCGTTGGCCCTGGCCCGGCCGGGGAAGGTGGCAGTGGCACTGGACTGACCTGCAGTGACCCGCGATGCCGCGCCACAAGGGACACTCACGGCTTCATTCGAGAGCTGCTGCCAAAATGCCTGGCGCCGCCACCGTCAGGGGCTGGCTTCGAGGACGCCCGCCTGCCTCGCGGGCCGTGTCCGCGGGACTGTGTTCGTACGTGCGTAGTTTCGATACTACATCGCGGGGCTGTGTTCCTACGTGCGTAGTTTCGATATCACACCCTCCGTGTGCCGCCTTACTTCCTGCTTTGAGAATGTATAACGTGGAAATCCACGGGACCAAGTTTCTGCAGAGGCCTTGCCGGATGGTTCCATAACTGTAGAGTCTAAATACTATCCATTACAGAAATTAATCGTTCAGTTGAGAGAAGTACTGATGACTTTTCAAAAACAAATGAACCATCGTAGTTGACAGAGAACCATATTGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGACTAGCTAATAAACTGTAAATGTAAACCATGCGAATAAAATGGTTTTCTATTTCT + HF5FDBB1FIHKJFKCE$KJKCHJKKKJKK=KKJJKKJGKIIJKIKKKKGIKJGKKIJKH6JKKJKKHJKBKKHJ4KCJIHKKJIJKFF5KKJKJKKKKJKGKJI?KKH3JKKJ@KKKJIKKK:KKKKKBJKKKKKIIH?KKKF-KKKKKJ?KDJJKHJKFIIJJJEJKEIJKGIGJFIKK2IKKKKHKJ@CJKJKKHIKKKKHKJIKKIJKJHKHKIKKIKKJKKKJFHKJBIKIKJKIKKKKJHJHJBJKFHJKKKK>DEGKJKHKKKKKKKJK;KGIIKEIIKJIKKJKBKKIKKI>JKDKDFJEGKKKIJHIKKKKKBKKKKJK@KHKKKKJKJKGIKKIIHJGKJC>KGKKKJEJJKIKKKKKKKJD@KIKI9EKJIKKIKKKFJIEK;KIGHKKKJJKKIKKKJ:KKKJGI@JIKJJKDJJJAKJKBBJJKKDIJIKFGKK=HKFGIKAFFCKHDJIKJKIKKG7>E0GCKBKKIKJCKJKJHKEJKHBK?J=K>?;HKCJJKKKKJHKJHKHKKDKKIJKJHKHJHKJKJKJKIKCKJHKJJDKKCKKK??KDKJKI>JJJ9KK?KKK?KJJKKIKKIKEKF>DKIJKIKKKJHKJHJKHKKKHGGJKKKKBKJJKJJKJKIKKK9CDKKHKKK@EJKKJKKKKJJEKD@KKKKKKKG5KKKHIEKIKJKHKG)KKKKKIKKIKKJKIKKKI@IJKKKKJBKKKJ2KKKKKKKJKKCEKK8KKKJFKJI?KKJEKKKKEKK8KKKJJJHKIKJJKKKKKKKKDKG:KKJ:KKKIJKKKJKK:KKKKKGJJKKKKKKIGKKBKKKKKKKJJ=JKKGHK>KKKJKKKKKKKKKKKFKKKGKKJJKKGKKKKKKKJ;KKKIKKKJKIKJKKJDKKKIKKK@KIKFKKKGK@KKGKJKHKKK;KGKKGKKJKKGKHHJKKKKKKKHJKKKKKKKKICKKJGKK?J@KHKKA;KIKKKKK8KJKKKJKKKHBKKKCKKKIKGKKJKJJKJKAKKKKKKKKKJKKKJKKGJK9KKKKKK.KKKF'KKKKIJKKKKHKKK@KKKJKKIKEKKKKJIEKKK>KKKKKJKKEKBKB @rCer/1435/1701_51_CCS ATGGAGGTTCTCTTACATCGACCGCCTAAGAGTCGCGCTGTAAGAAGCAACAACCTTCTCCTCCTTGTCTCCGCCATCTGCTCTGCAGTCGCGAAGCAGCAACCATGCGTGAGTGCATCTCCATCCATGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGAGCTCTACTGCCTGGAACATGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGGAGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGCAAGCATGTGCCCGGGCCGTGTTTGTAGACTTGGAACCACGGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCGAGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACAGAATTCGTAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTTGATATTGAGCGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCCTGGCCACATACGCCCCTGTCATCTCTGCTGAGAAAGCCTACATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACCATCCAGTTTGTGGATTGGTGCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGTGTGGATTCTGTGAAGGAGAGGGTGAGGAAGAGGAGAGGAATACTAAAGTTAAAATGTCACAAAGTGCTGCTTTTACAGGGAAGCTTATTCTGTTTTAAACGTTGAAAAGTTGTGGTCTGCTCAGTTAATTTGTATGTAGCAGTGTATGCTCTTATATACAATTACTGACCTATGCTCTAAAACATGAATGCTTTGTTACAGACCCAAGCTGTCCATTTCTGTGATGGGTTTTGAATAAAGTATTTCCTGT + 61A$97.;(=*CE;AE=C:BA0;:F2DFH@?ED4A>AB9>7D66=ICA=>=3G3GDCC0BDFDD@EE5EC:?;G=DB3;?C@BABB@=;AB0?G=EC:AD?+?CBE;E>BC+<98C7,>;9@C8G8D:@7EB=B4@A?/(6%;1:<F:4;0@AB6:?C@B@%<;1=>;A<.5?=%3@1F9EDCAE75:=F?+?0B=B6?$6>C5@>;929:><:993-=FC;8:>21@C?A:@)-B=DBF4@BC4D?8FDBAAB9B1F19?=%><=%6;>:A@8:;@?.E=BB;@:=A?A9>@6E>G7>0>ABE:A:?><@?3=8BB8;((?:D:9=?;?+;B9C5?5;891A;<8+9=<75<;)>AC-A<@B69,>84@9@%<>B?E96%19EF:C->;=/@FG,D>D?@9;B:G=;:7;=C@FD6A31A;7@9D8B<:=GBBCC>E8:B;B-1BGBABB998A*>BB:3-84;;?*AA5CC/@9DA>;;A7158G5??=.B<@?>>@=8?;8-.@8B>=/A@?2BA91$70<-7@729<;77/5?<;7?99B=A>B?B9@<3;;1;;39=;:4<3>5<6579'5868=88'>,:86<8<9@B?B<<=A4::41?27)99A?<<=A:@<>@=66.;:*8>=A6-B7>;:>:86>?>>:;C>=97B9<;;'?7?;9:5'=;?8?<<7?9?7<;@4C08A9:=>2.@79;A@29637<5A88.=;<'@B1@'93>:;@:ADB4@@@7886<>=>BDC;=AC&AB,A0&3?@B:C@83=C4>;BC?E?;CCA>@E9@AC=C?=D1@@;=*==D693:@C=A9C>7:52.;98&6:@A.6BA>>7:27>7>5<,<>9<=;:<,==8-47<=/=<5*B?;6839%@,CB7AB.:07199@6>B:;=C25C;??8%:7/>.92A09+..0740389CA=784977.==;::>:76A9?C7<)*?1/:2AC?C<@*B4:4<<=B<:793678<11//:=;@96>C;6'C>?>9(<==>:.9A-:B6AAB;9?B.=A<:;?47?6>0>::@@@/<<-8@0>B9>A4=89:8362:;0/61';?>5=B6?9A;BAA;;::%=<>75%AB-;A@>&:=;=4<5A<=CC1;46:.@3:54<6;752?<55+4'$/87>9*5+5=3(7>9:1:<6<7/2/6)$=+&*850264*<1964+;;.6>48;<+;6<<:09*બ><=9914<<==1;';55-2<+229263*:?8:2=0=>;;2:70;4<1976=3=<:587;89<081307404143277><;>;8=3:8=<290*;33=9>=7,934,99648<=):8;8:357=993491:=*75/5%?9;828=9+53;==><:<>;:5,589%2:2>??&7?B?B2AIDIFKKJKEKJKKJ,K*<7&DIJJBF#KKJJK?KKI2KK<'JKKKKK1CH5JC&JI/KJ1IK9KJIEIJFKKKJKKKKIKHHIEI6KKJKDGH6>GKKHKIIKKHIHGJFGKKKEIJFJFKK@BDJEK0KK,JKIJHKJIKJKIHBJHKKEFCECIKKKK/JJFJHIJH8HIBIKJDGKKJKKIKKH7B;EI:KEGIJ#GD>@>CFHBCHGHI8HHKKK=KK1KKKGHJ)KKKJFFJ=K5KKKIH&JIHKI$JGKJHKJKKJJKK6JKKIJ%FJJJ9KKIJJ@HCFJ8I1KIKGHJJBFJGGKJJIKJIKKKFKKKKKJJIDA,K=HI?KJ7KBJJ1KKJDGH?DD.KKIKJA@KKKKKKIDJJFDHBICHKG1JKKK$IBIIKKKJH1KKC>'8?04/,.EKGDKJJJKIKJIKKGKJJKDKKKKJIGB1CECI7GFGACIIHEF@JIAJIFKH(BEGFKII7FJKKJJJJ6HKKKH5IAIK8KJKJJJ;JJBKI.KJIF@:;J?>KJFAKKKJJKBKKJKDEGKIKKHKHKKIKKKK7KJBJJJBGE0G=KKKKJKKJKKKKKJK-@CFGFJK5KJKKKKKJHJIKKIKKGFKKGBIKKKKKKFK4KKKKGKCKK@JJJE?KKKKKJKIIK&HJIJKFCKKKJKKKKKJCC7HJKJBGJKHJGEIKEKKKIKKKKKJKKJIKCKKKKJ2KKKKJKKIKFHGKKDBK>HF$CHFGDFJKIKHKK8HHCEEBGIIJF:HFDCJKJJ0KKIBKKJJKGH;8C.IJIJKKIJKKKEKIEKHJKEKJKIJKKBGAC7JAJJKJFDKK@IKJ#K7(>@;?GJH*KKKKKKKIFJHKJ=KKKK8>@3GKIHEIE9KKCIJKJJGGKJ-KHIB1KIIIKJCK>JK;KCKJJHEKKKG&FJGJHJ(K2(>IKCIIJKKKHHKKFFJKKIDI)JKHI?CKADIKKKKGJKKJKJHK4KKHJHFHGJ)KKDCGJAKKKH6B>@CA-7KJ @rCer/1441/1937_54_CCS GGTCTCAGTCGCCGCGCCAGCTCGCGCATCTTGTTCTTCTGCCGCTCAACTGTCCTAGTCCTCCGCCGGTCGCAATGGAAGAAGAGATCGCCGCCTCGTCATTGACAATGGCTCGGCATGTGCAAAGCTGGTTTGCTGGGACGATGCACCCCGAGCCGTGTTTCCCTCCATCGTCGGGCGCCCCGACACCAGGGCGTGATGGTGGCATGGGCCAGAAGGACTCCTACGTGGTGACGAGGCCAGAGCAAGCGCGGCATCTTGACCCTGAAGTACCCTATTGAGCATGGCATTGTCACCAACTGGGACGACATGGAGAAAATCTGGCACCATACTTTCTACAATGAGCTGCGCGTGGCCCCAGAGGAGCACCCGGTGCTGCTGACCGAGGCTCCTCTGAACCCTAAGGCCAACAGAGAAGATGACTCAGATTATGTTTGAGACCTTCACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGCGACGGGTCACCCACACGGTGCCCATCTACGAGGGCTACGCCTCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGTGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATTGTGCGCGACATCAAGGAGAAGCTGTGCTATGTCGCCCTGGACTTCGAGCAGGAGATGGCCACCGCGCATCCTCCTCTTCCCTGGAGAAGAGCTACGAGCTGCCTGATGGCCAGGTCATCACCATCGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCCTCTTTCCTGGGCATGGAATCTTGTGGCATCCATGAGACCACCTTCATTCCATCATGAAGTGTGACGTGGACATCCGCAAGACCTGTATGCCAACACGGTGCTGTCTGGTGGCACACCATGTACCAGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTGGCACCCAGCACCATGAAGATCAAGATCATCGCACCCCAGAGCGCAAGTACTCAGTGTGGATCGGTGGCTCCATCTTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCTCCATCGTCCATCGCAAATGCTTCTAAATGGACTGAGCAGATGCGTAGCATTGCTGCATGGGTTAATTCAGAAGTATAAATTTGCCCTTGGCAAATGCATACACCTCATGCTAGCCTCACGAAACTGGAATAAGCCTTTGAAAAGAAATTGTCCTTGAAGCTTGTATCTGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACCGTGTATTCAAGTTAACTGTTCCCTTGGTGTTTGTTTAATACCCTGTACATATCTTTGAGTTCAACTTTAGTACATGTGGCTTGGTCGTTTCGTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGGTGAGTCTGCATGGCCAGCAGTCTCCGATCTGTGCAGGGTATTCATGTGTCAGGCTTGAGTGTTCTGGGATTCTCTAGAGGCTGGCAAGGGCTCCTGAACCAGTTTCTGCCTGCCAGTCTGTCAGGGTTGGAAAGTCCAAGCATAGGACCCAGTTTTCTTAGCTGACGTTTTCTGCCAGAACACCGTGGGCTGTTACTGCCTTGAGTTGGAAGCGGTTTGCATTTACACCTGTAATGTATTCATCCTTTTAATTTATGTAAGGTTTTTTTGTACGCAATTCTCAATTCTTTAAAGAGATGACAACAATTTTGGTTTTCTACTGTTATGTGAGAACATTAGGCCCAGCACACGTCATTGTGTAAGGAAAATAAAAGTGCTGCCG + >(>57>>??@EB9:$<9(:9;16.(4,;D7E=BD9?<;::5A+???AC37@D+J;<>G;B,4<'AF*E1B?DGJ=7H9C:ED6;;=E@8>@(:??.8FG8C>?B0>98C@%A?79G>BHKIK1;HCKBH9$6F;>H3DHDIHE@BGHJ.D7AD:D;FEF*@G&GA29C9=?7<@.;7DHD.<1047'9FF4GDHAC>G@8?*AGK>FCIBGH%HKBK9B@*D$=JGIJK4JKIIH&:CH>H7H@KK>J?E+:?ABG5=JK:I2CD2GKFD=G8@@8:@.<29GKK)6HACIK3GIK?CK<@/=@=8HC3DE>1JJGBBHJEIKJKHGIK19I@J=K6I2A=I8<75:,DGFHHDEKKJDD+AKK/FHJJK4KKK*JKHKK9K0K5@CHJFCBGKEK>AAICKKIK7IKKKHIIJD)IBGJ;DK@KKHKJ)EIBHKAHI?K6?6KBK:?EAK-BJGJHK/KKGGJJ%EIIKJGIHAKK=K7JI&J?>=;HFGKK4FHFFJK&;HJG$8/1D3BJJ:@KKIIFEK;KK=JK>KBKJGK:FKJIJI'&9BI.7:GJCGC>KK;K>HKIH=GJJ1EEKA3E/?G@?GJHKIBJFIFGDGK'FKEGBK:GJBJJKJ6CE*05KDJDEK?FA.3>AH?2J2KBH&;DH.:=;EFHDA>:>2CKDGFG5CE;;IAKFK%>?KG?C>75BJDI9EG>@7>7EHD=CAI>GK4HA%*GAE>AC9<'<;'E5G,IE4ICJ7KFI02ICJKDJ?E<@JCIK?JKI=FKDCDI;5CE?@2:A41BFEK*;=IK@GK>IHK@IJJI=K8K5AG@I>8?KDHC8F7J=FA?0@@?A??9HJ>IJKK5BJAD&AGJJJC1IFA=FJK?)JF$>KAHEJHBJ=4GIHIFK;FH=G6IIKJ9EC8;HJKKJKHAIHJHDEF@HAA%EGHE@?:KJ4J7J=KEK@GK6IJEEDD$FG9HKJ@K=K9CGJ)DHIGFB5@K>JJB@DEFEEJ27EBHJKJ=ICK@KHI;>CK;GJ3JIFI$6KJ(?&JFJ?J6KJ8IFGE=IC@135,3=9>)2AD/GDG-FH'C,BJDGK1KIHJ6&8@AK1HIFIH:7ECB>I?CIE;HD:>I(?E4C=1;>B2B=B?)@5$4597DAFB9=03(843<@3CG:<(A?C<98,5.0:E&)I49B>+@=80*>D@B027,DA>E04&=./EF>@@3A<:D;417?D2IFDE%.69CA7=GD@%FCC&<%II@4:<<=(E/>?ADC;$=<;>A:?+H35.?G,D7@HD>GH==IGA:)<<:6:6D>78<<4'?E7C=?1BA)IH.3=;$9A@>>=,I+;053C5>1@ED$?@DE/EDA2<==4@ @rCer/1443/0_1624_CCS GTGCTGACTTCCTGGTGACGGAGTGGAAATGGTGCTCCTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGCGCTGTGGACTTGCCTGCTGTGTCGGAAAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTCGATATGGTGTTTGCGTCGTTCATCCGCAAGGCAGCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAAGGGAAAGAACATCAAGATAATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTTGATGAAATCCTGGAGGCAGTGATGGGATCATGGTGGCTCGTGGTGATCTAGGCATTGAGATTCCTGCGGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGGCGGTGCAACCGAGCTGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAAGCCCCGCCCACCCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTTCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGATAGCTCGTGAGGCTGAGCAGCCATGTTCCACCGCAAGCTGTTTGAAGAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCAGCTTTGATAGTTCTGACGGAGTCTGCAGGTCTGCTCATCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATGCTGTGACCCGGAATCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCTGTGCGTGCAAGACCCAGTCCAGGAGCCTGGGCTGAGGACGTGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGAACCTGAGAGCCCTTCCTCCAGCCCCTGTCCACCCCCTTCCCCAACCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAATGTGGCACTGGTGGGCTGGGACACCAGGAAGAAGATTAGTGCCTCGCTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGACAGCCCAGAGCCTGGCTGCCTATCATGTGGCCCCACCCAATCAAGGGAAGAAGAGGAATGCTGGACTGGAGGCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTTCTTCCTGTGTATACTCCGTCCAGTTCCTTGAGAAAAAATGGATGCCAGAGGACTCCAACCTGGCCTGGGGTCAGGAAACAGCTAGAGAGTTAGGGCCTTAGGCAAGGGGCTGTTGTCCCCTTGAAGCTGACTCTGGCCCTGGCCCTTACTTGCTTCCCAGCCCCTGGGCCTCCCAGTTCGCACTGTCCCCGCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCGACTACTGCAGCGCCTCCAGGCCTGTTGCTATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAG + S-.%-1.,,1/2--1/,().10*0'(*02()/+$),0*$-253355/53/5)6873.5-66:)63:2'44/(?40,;A@6&;:);<;B=*:,3B2>-CBB*63:<>$052?>$699<8A=CCD=BE@1ACF9:997C=='9;9DBFBC9B>199AFDA@C?@EC2;+)1+332;6B@7>@&=1439=148:?.>F;=FE:C)B:?BC@@*B@@9.>;;GD@E2BA=9=B4:DE1D2:B?)'$3166;60DDA9AE@+>>:E9?@C27C7AFA@;@'?DB2AB:6'&B>E;<@6E8?1C=F88?;87/@&?>@)>/:E??%D;<=9,&@,907=>:/87;=>2>:8<<23:@B*:;>.*A4>);<::@93=0),=(>@51$4A/2BG(E?26;7D:BC1B1=BEFCD/D8+4E98*@7@AF?>@@E41/=7;;A0?CA>0516'B@=BB.7.E(7%:D?<>@7:101>895<@9?B>3?;1C?@>C&;:A/@A=D>A)>==CA<);14B=*C<8+;;3>66@4>DA?@FCB>=<@A<=>>78-:54>5:@@;><7B(>>4:8A?G(A>B%>><=@9;15G=5DC*?>69/4':154/;:,?>FCB>>0%9>>>;;9/:94;<@:D0%0B5%6B7@>B.@6CB;E@:78@(A:F8(,13&A3-?E><.?>(8:A95670%:HD?=DB+BD2F+=7*FHBA>D@?FAEGF=:2:5FF?-?6>809D7;,E;<;232'C=?98=$<<@6?-7=HE:3+/@B2@8$'=C;JD+4C>7G@8<>)@C?CB;CF,C?83;3>B&@.A*A>@A1<*8*FIAC&<.'3@6BE8B?>G8BJFAGA5G4G7><1>837A>DB.J&<;A59@<$C:7C<97ICCA1JA=C>,G@B:B:863@@I*?9CA>3D=67<=C9J?G>=3+)@A:427HA2HD>A5IGAF=4B:+F>GD@JC@(9=@D=+DBCEC;H4IFF;C6H@?BBA-=CCHCB3IG;=09?9AI-DCBH?8GD;F942:<=JEFA;I:8;EC.724A&?9874G>BG>B2F,EF@FA1.%:0<3A+>A20:7DF;F8+1*FH?/F/??I>AB6-@;/J26.AE>@:?8?E%<6:)B8F8>*A0A:59=5I@>;DD0>H*I,8;C+,DIJDF<:C.HF=@E=-3,:,;+-?>+DI@@%A@?+=A@H?B99/BEA?E)A24;>=5B:@;@-@9;2&?ACB5FB:A84?=9A8AAE:<#7?34DG?:(B7/9=6362.4ADB8F;C=CC3)CA?A6A4EA0EB?*=7,=>=-=?2E2D>G9+DD?&;9801985=88715?E;/.@:6=2<.*<96KKGCKKJII;JFIKIJIKJK7I:J;5-*7:BKIFK@BKKKHJI,KJ1JA.BIFJ?FG8AIIG@GKIKKKKJJI?CBKCK.KJHHICKKKDKKCG4KKHKCEKJKKKKKKK?JGEGKKKJJJKHHKHKKKKG=>IACAKKJKIK9KKKKH3KKKHKHIKHKKKJJE?D:IG?FCKIBKK8JJDI0JJKKKCJ=KJ>BKI&KG@HJJ?:KFJFEFBKKHEEJFKHKKFJIJKKKGKJFKJDIIDG7KJHIKK3KI;GJDK'GJEHKFJKEKJKKJ,KKJ.KKJKKKKG=KKIKKKKJJKKKJKKKKKKK?KJKJKHKKKJK=K)KKKKKJJKJKJ;KKKGCKKIKHK=KCKKJKFJJKKD4KIKKKKK.KEJIKCK:K'KKKJJHKGKKKGKIKKKAKKKIKHJKGKKKK9KJI?AJ@K:KKKKJKJEJDAKK.KKJC2JKKJKK:K4F=AAKAKJD/KKKKIEJFKKKKE'KKKGKI?JKKC<=IJKJ:?KIFEA6@KKKHJJKKKG/KKKHKGKGKKKFJFIJKG>BKKKKKHKDKCJK?KIEKKEKKKK@KJIJGIG4>@KJKKKJKKKKJKJJKKKIKKJJKKKKGF,KGB)KKKK*JKKKHDC-IIF8KKF/KK=KK9KGBJCJKJKKKKK8KKCKKKKJCIKJJ9KCKK-K?CKKDIKK;KKG9KIK'KK?K4IHJBIKJKKJ<@KDAKDKCJKKKFIHGHKAKJKIKJKHKKJKKJKKKKKKCKJJJKJHBKJK;KKKKKKKKHHKGKKJJJGEKKKKHG8KCJ@KKJIIKJ3KI@FKKJA3IJ/KKJ@JAKKJJE@KKFKKK7KKJFFGJKCKIHJ?J,IJKHKJ7IIKJE5JK:0KKG'KKKJKK'JKKKKJKKAKIHJG9KKKJKKEJJBKGIKKK=KK9KHHBKBBKKHKKK)K(KE.KKKKK3KKKJBJGIKKIHIKBIJIKIEIKKKKDKHK2EHBKKIJKKKDKJKIJGKJKK?KK@GKKKEKJJG2KEHEHJJCGJKKKKKKK:J.IKFKG5KKJKDKK@K @rCer/1451/21_1616_CCS ATGGGGACCAGAGGGCGCCAGGGCTGCAGTTGCATTTGTTTGCCGATCAGAACCCGAGGTGTGCTTGTGGCTACGGCTGCTAACTGGCTGCGCACAGGGAGCTGTCACCATGCCTCACTTGTACCCAGCCCTTTCTGCTGAGCAGAAGAAGGAATTGTCTGACATTGCCCTCCGGATTGTAGCCCGGGCAAAGGCATTCTGGCTGCGGATGAGTCTGTAGGCAGCATGGCCAAGCGGCTGAGCCAAATTGGGGTGGAGAACACAGAGGAGAACCGCCGGCTGTACCGCCAGGTCCTGTTCAGTGCTGATGATCGTGTGAAAAAGTGCATTGGAGGTGTTATTTTCTTTCATGAGACCCTCTACCAGAAAGATGATAATGGTGTTCCCTTCGTCCGAACCATCCAGGATAAGGGCATCGTCGTGGGCATCAAGGTTGACAAGGTGTGGTGCCTCTAGCTGGGACTGATGGAGAAACCACCACTCAAGGACTGGATGGGCTCTCAGAACGCTGTGCCCAGTATAAGAAGGATGGTGCTGACTTTGCCAAGTGGCGCTGTGTGCTGAAAATCAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAATGCCAACGTGCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAACGTTGTCAGTATGTTACAGAGAAGGTCTTGGCTGCTGTGTACAAGCCCTGAGTGACCATCATGTATACCTGGAGGGGACCCTGCTCAAGCCCAACATGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCCAGAGGAGATTGCCATGGCAACTGTCACTGCCTGCGTCGCACTGTGCCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCGAAGAGGAGGCATCACTCAACCTCAATGCCATCAACCGCTGCCCCTTCCCCGGCCCTGGGCGCTTACCTTCTCCTATGGGCGTGCCCTGCAAGCCTCTGCACTCAATGCCTGGCGAGGGCAACGGGACAATGCTGCGGCTGCCACTGAGGAGTTCATCAAGCGGGCTGAGGTAAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAAGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGAGGATAGGGAGCCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGGTAGCTTCTCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGT + FK3JKKJHK?KK>IKFJ?KI6KKJ>KKKKGKKHGBJKF=IEEKKKKKKKFJKIJKJH(@E2GIJ?BEJ9KEFIJDKIJJJBKKJI3KJKAKKJKIH1KKJKIJHKHKIKJKKEKGKKKDKGJKCDFJH7KJ@JKJKKFKKKJJGKKKKJKFKIIHJJKJIBKKKCKG4KKGDIKKJIKGHH5$HFKJJIKKIKKC6GCHJBK.KIIIDBKJ8CKJJ79JAKFIJIBKKJJFKJKGKKKCK5KJJGKKFKFKJHJKKKKFKKIHIFFBGDKJG:IFIEKKKFKKIJKIKIIKFIGJJCKKHFKKK>G9GD6EHJKBI>JJB4DEAGGKJHKIJJ=KIKKJKHKFKKHKHJ>A@KKFKEGIBK>GKCGIKJKFKKKKFKHIKJJCICJJKK>IBEJHGKJHCKJJKIKJKJEJJ,JHCKJJIKKJ;K;KB94JCIIKKKCHHIJFJF=$:KKKJJ6JJKIFJHGHKFIKJKHKKKKK8KKKK+KDFKJKIKKKJKKDKFKH9BGKJ2KKKKFKAKHFE5HHK>>KKDKKIKKJHKKBKIKKKKKJHJJDKKCKKIKJJHKKIKJIJ957'EGKKJKKKG,KJJKK9KKKKFGJKKJHKKI+IKIJIH@KKKGKKKJIJKKDGKFGHJCHIGHKKIIIKKHJIJKBKIKKJJKKKKKKIKBGKKKHIKKKIFJKGJIKK7KKKKIGEJDKKKKHKJGJDI+KHIJFKKJJIFHDIJ>?ICHEEKFHI8CKK?H?H3KKJC5JFCJJEDKAEGFI2KKKII=HF@C;DHHFBHBKCDBE2KKK9JGGKKKKF%JHJJJKKDKKHCAKKKJKIJIJIJKI=KKKKHIGKGKJKJKJKIKKKKDKJKAAKJ@KEDIK,GJKKEKI*JKJKKHGGKKJK=KKKJH=KKJIIKEJIKFKKKJJJJBKKJIHJK:IJIJJGKIKK;JJKIKJKKHKIKEKJ4KIGHADICKJIKKH=B@=ICHBJKJAHKKKJKJ*IIFKCFHGBIK)=866*5.57255:8;26<96<<4%.71<:53../76*598/528311)*5&16674$766>677:)971;:=6:7546..2%5-/512;4=/82?8*-30- @rCer/1453/237_56_CCS ATAGTCCATGATGATGTCGTGGCAGAGTCTGATTTCTATATAGAGGTGACTTTTTTTTTTTTTAAGTACTGTGCAAGCTCCTGTGCTTCTAGAATGTGGGAAGTGGCTTGGGGAAGATGGCCCCCAGCCTAGGAAGACTGTGTGTTATTTGTTCAATTTCAATAAATGATTTGTAGATCCT + &#%$++%'(+--,*--,,%$&'&'))'%())(--))*('$&)&#'%+,)+*''((('))&(*",-----&*%$%&&)%$##)*(,)+)+$$,-(+*(&%"'#%#%#&&&+,-+('(&('((&&)%()-)$+.+.-+$+('$+(+,,,($''%*)('-'''#&$''#&*),,)+/)(%(*)$ @rCer/1454/2217_59_CCS ATGGGTGTCCTTGCCTCATCTCTGATCTTCCCTCTTCCATTCTCTTTATTTCCTTCCTCCCACTCTGACTCTAGCTATACTGAACACCTACAGTTCTTTGATATAATGTTCTCGTAACCTGGATCAGTGTTTGACTTTCTGTGTCCCCTATGTGTGCCTCATTGGCTTATAACTTTTTTTCCCCTCACCAAAAGCTGTAGGAAAAGATACTGTAGTATATATACCATTACCTCCTGTTTTACATGGCACTTTTCACATAGTGTAGTGTTTACTTTGTGAGCTGTTTAATGTCTTACTCATCTTTGTGTCTTTAGTTTAACATACACATTGTTGTACAACTGAGTTAAAATATTAGTCTTCTTGAGAAGCCTTGTGGATATAGTAGAGACTAGATCTGAAGTAAGATAGATTTGGTTCAGATCCCGGCAGCTCCACCACTTAAAGGGTATGTGGGTCTTGCAAGGATTACTTAGCCCTTCTTCTCTGGTCCTGTTTCTGTAATACAGAATCGTAGAGCTCATAAACTTGTTAGAAGGACTGATTGAGATGGGTGAGGTTTTTATTGTGCAGGGCCCATTATGGCGCTCCATAGATGTTAGTACTCTTTTCTTCTTCTGTATCGAATGAAAATTGAATTACTCCTCAGAGCCCCTCGTGCTATATGTCATTGAAATAACTAGATATGGAGTATTTTAATGAGAGGAATTATGAGTAGTTTGTTTTGTGATTCTTTCATTCATTCAACAAATATTTATTTAATATTTAGTATGTGTCAGACCTGGCTGAGAATATGGGGATAAACAGGGGCAAGGTGCTCGAGCTCTCGTGGGGAACAAAGACAAAAGACAAGTTAAAATATAGAATTTCAGGTAGTGAGAGCACTATAATGAAAGTTCAGGCACTAGGGAGCAGGGGGTGACTGATGGGTTTAAAGGGTGTTTGAGTGGTCAGGGGAGGCCTTTCTGACAGAGAGAGAGAAATGGATTGAAATGATGGGTGGTCCTCTCCTGCAAAGATTTCTACTTAAGGCCTATGTTGAGATGTATTTTGTGTTAAGATTTCCAAACTGAGTTTATTCCATACTTTCCTACTCATTTCACAAAGTGAGGCTAAATCAAGCTAACTAGTGTCAGGTATAAAGACTTTGCTGCACATAATTGAAGCAGGAAGTATCAACTCATCATTTACAGTGAATGTAGAAGTTTCCCCCATTACTTCAGGTCCATAATAAAAGCCTGTTGTAGGGACTCAAAAATTTGGGTAATATTTTTATTATTATTTTGCTCTGGCTGGAGTGCAATGGCATGATCATAGCTCGCTGCAATCTCAAACTCCTGGCCTCAAGTGATCCTCCCACCTCTACCTCCCAAAGCACTGAGATTATAGGCGTGAACCCCTGCACCTGGCTGAAAATTTGGATCTTATACCCAGTTATGATTTCAGTCCTTCCCAACTAGCTTGTAGATAAGAAAGCCAAACAGATCCCTTAAAGAGTTCAGCCTTGAGTCATAGGCCTACCACAACTCAAGCCTAAAAATTATGAAGAAGTAACTCGGCAGTTGGGAAACTATTGGCTTATAACTTCTTTTTTCCCTCACCAAAAACTGTATGAAAAGATGCTACAGGCCAGGCATGAGGAGAGGGAGGAGAGGGAGGAGGGAGTAGAGAAGGGCGGTGGTGGGGTGGGGGGTGCGGGAGGAGAAAGAGAGAGAGCAGAGGGGAGAAGAGGCAGGGGAGGGAGGAAGGAAGGAAAAAGATGGTATATATGCTATAGTTTTCAGATTATTTTGTTTGGAATTACTGTATTTCAGCTTTTTTATTACTGGTATTTGTACTGAGGTCGTGACTGTGCTGACAAGGAGAAACAGTAGGATGCTTCAGCTGGGTGGCGGTGGCTCACACCTTGTAATCCCACACTTTGGGAAGCCGAGGTGGGTGGATCACGAGGTCGGGAGAACGAGACCATCCTGGCCAACAGGGTAAAAACTCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGTGCGCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAGTTGCTTGTACCCGAGAGGCGAAGGTTGCAGTGAGCGAGATCATGCCACTGCACTTCCAGCCTAGGCGACAGAGTGAGACTCCGTC + &)&)&'+'-&-+-.**&%,,&+--)(+-&*+(+,,)-+,,)(,(((&'+-)-*-(-,*-.,---*-),,+----,(,),)--.-+%)%%&(,-.-,***+#('*($(,,),)-+--).,-.,+,+),*,-+)+)*+*#'(,-+---,((,-,----.,--,,)+'+.,--.,,-,-+,+$&*(#*--.----)),*-+(++(+,&)&%,'&),),+,*,)#&'-+,-((-*,.),+,,,&+*--.+*,-,--(),(,-),),+()++-*',+-.---,),,%%(,&,,*-,-*+(),---+++),(,+,--(+(-.,-*)+($,---.--.+-,')*+-,---*+--$+)-.-+(&)&'((#(--.-+)%-+,()##+*(*+),,($+*--(-,--**#,-.+(,,'--..,))-)&'+-),-)-+,)-,-.-,.---,)-,*(,&,+%*,,-+-,,*(,)).+'.,+-.+()--,+(*.,-+)-.,-,(%+.-*----)'(+**#,,*---+-+---,+(**&())-.---.,+')),*,-)-------(,-+.+**+)&,%(++)&'*-,..,+-,(+,--)))*'$%&$$%)''(,(,-+*%$#$&,&((%+&&&*(+)(&+-...+-,-*&+'(,*--,,-*(*-,-+(,*),)&++)(,+-*,(,,*&',(*(,(+*&%*$,++(,+*'*'(,+',--,*,&(())(%+*--)*+)%&)'(*-&)*-,((*-,()))-+&*-(,,+,(---*+)-,--*,-**+)''+(++&-,-.++(*-,.)$%%,,+&,++,*+(+(*$'+%-*+-,+-+-+*+*((,-,,,*-+)')&+,,-),(--+.++*%+,*'&#(--.,,-+&,*,*---(#(-*+(-,)-.+&&--'-.-,*+*+&&#),*)*,-*&*)-%'+&+(+,+%(%+,%)(&*,%#&'+$,,)-.,(%&+--',-+-$(-(),)$%$%+,),-+)(+(%+-,++'($'%)($,.1,).,/200110,*0.22/0,0/,-)1.01201*2-110.1+10,/-,-12.0*-/-2.0+-)01,/,01-011(1220,1,2-,/0100+.0-*&'-0.2/1.-*,#/-///+*/,+%*'/-.-.-&,.-1(011.211--)1*.1*.*+.-11,%*/01-01/0)/10210,1.1-121'1.,,11/2/10,/112111..1.*10/.+011'-1,*+..-12012,111-.--0)-2-,,001.001),0+0100-)(/-+.*+'(,*)//-%-0./2.1,/1)-11100*0.2-+.1,(,+*.)%.1112111.0,0...1100-)/0+0/&00//.2/1)100./+(/121120-%1/01.121/0,*,,&.-0110+*,'')-,2-,-1-.-...---)-.--.--+,,,)&-.,.-,(%*&,+(--*''.*+&(-,.,,---+(,--*((%(&#()*,*+*-(&,)-..-+*'+)$('+-(--&('-.,)&&)',***((#(-),(*'(-(-*'',(()*),(,*)'%&(*-,+(--+&()'%-,(+-),--.+,+(-,--'++$''$()-+,,')**(,.-)+,,,,#)*',--,)-*--*(,--))((,*%*,((('%,*(','+,(&)+((,((,-,-(-.--,-..,-*)+-.*)*),+*+.---)++(,.-*++,%',,,+-%)*(%)$+*(()$$$'),-))(%#+-,-..*+(+,()***,-+,-))--'))((+))+*'&*,--(-,+.,)*,*%)(+)+*,(,---%,,*))*,,+(&)--(,(*(-,--*--,,'&*'&(()**&#(-),,***-++,&,-))*--.,+#)*#&*-*-*)(,,',((**+,+'&$((-,-,,--.*----+-+)*$$('&*,'*)(******%&&-)-..,#+**+-%-.,-),-),,,)))'#+-*,---),*),-,-(&)*('+$(+-.---.---'-+,+&,&--)&+'($-,)---+-)&,(%),--(--**&*+#)*++,&)-+-*+.+),**(&((&$,-*(,-..)(('$%,-+&(%#,),&,-.+*+.--,-+*$,-.,---..-),+%-*-)-,.*-,,),--+''#+,---,,(+-,-)))),+)((&+(-,-+.)-,'(-,-,,-*---,.+,(( @rCer/1460/2366_57_CCS ATGGGCGAGCAGCCTGGAGAGGATCCGCGACCGCCGCCGCCGCCGGAGCCTTCAGGGCGGCTTCCCTCGCGCTAGCCCGCAGCGCGGGTGGAGAGGGGCGGGGAGGGGGGTCGGGGGCACGAGAAGAACTTGAAACTGTGTGAAGGAATCCGGAGCAGATGAGAAAGGAGGAAAATAAAACAAAGTGGAGACTGCAGAACAGACTCCACTGTGGCTGACTGTGCCGGCTGACGCTCCAGCAGAGGGGCTGGGTTGGAATTTTTCTCTCCATTCTCTCGCTCTCTCTTTTTAAAGCTACACCAGCTCTCTCTCTTTCTCTACTATCTCTGTATCACCAAATCCTTGCTGGCTCTTATGGGCATGAAACACTCCTCCCGCTGCCTGCTCCTAAGGAGGAAAATGGCGGAGAACGCGGCCGAGAACACCGAGGTGAACAGCCCCCCTCCCAGCCCCTCAGCCCGTCATCCCTGCTAAGCCAGTGCAATGCGTCCATCATGTGTCCACTCAACCAGTTGCCCGGGACGGGGCAAGATGTCCAAGCTGCTGAACCCGGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTACGCCCACTTTGGGATCCACGAGAAATGCTGAAGGATGAGGTGCGGACGCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGACGTGGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATCATTAAGGCCAACACCTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGACAAGTGGCTGAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCCTGTTTAATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTCTCGTTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCCCGATGCTCCTTACACCCACTGGAAGCAGACCGTCTTCTAACTTGGAAGATTACCTCACTGTCCGGAGGGGGAGGAGATCTACGGGACCATATCCATGAAGCCAAATGCCAAAAATTGCGAGACCTCGATTTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATCTAATGACTACAAAATGCGTTAGCACACGTGGAAGCTGCAGAGAGCAAGAGAAAAGGAAACTCTCGCCTCGATCTGCCGTGCGTCCCAAAGAATACCGTTTGCAGGACTACACACCTGAAAACCAGAGTTTTCAACTCTGCCTTGAAGACTGGTGAACTCCCCAGGGCTCCCCGCGGACTCCACCACTGGACAGAAGGCCTCCAGCCCTCCGCTCTGCCCTGGGAGCCCTTCACGAAGGCTTTTGTGTTGCCAACAAAGAGCGACCTCGCGTGCTGTGGCTGGGCCCCGAGGGTGGAAACGTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTGACTCTCCGGGTCTTCCGAGTTTTGCATGCTGCGGGTGTCTAGGACAGACTGCTTCTACTAGAACCTGGAGACATAGCATCTTTGATAGCATAAGCCAGACTATCTGTGTGTGCGGTGGCGTGTGTGTGCGTGCACGTGTGAATGCGAGCAGCAGAGCTGATATTTACCCACAGATACCTGTATATGCATGCATATACAACCAAGTGGGTAGACCTAGGTGTTCACTCAGAAGGGTGTGTGCGTGTGTGCGTGCGCGTGTGCCTAGAATATATATTACTCTCAGAGGAGATTCTGTTGCTTTGAATAGGAATTTGTTTTGTGATTAGTTCGCCCCTTCCCCACCCCTTACCAGATGTTAAAGCAGCTATGAAACATTCTCTGTACTAGCTCTGTCTCCTTTGACTGGACTGTGGCTCTGAACCCTGAGCATATACCACGGACTCCGTGGCGCTCAATAAATACACATG + -/.0*+031122355145556501*/310.*&5-33125/14%*+*14302/0311*.0(03,/4)56453/(2312*0.2456621/54333013/)-131'-332/1%*/3/11(16210/2)454260555,56/53000)3(401600)/(2.+1232./5+2+/,%31/'*1/3)455)2261412241315634-052.602341561656254/(20&1-51215213)'*..0-,.,1+45134/,5/632/22&%*')1+34*3,21530*21/-.232/&55/2115446013255121301.3+)),+250.-.,5243+0/.2566/10*6*3311-401632566.0-1-663315462066055*33)-505352-13/66056626215625242/.+((1*+-5115040011.536566253422$,.1&/*144'/202/2*303/.460*/201&,62./.556030)1465432.0///0500445+#2%2-1)255)62.15633.54.52-406/614.151*16*02,4042041+4516210-/-3415,,+(056551124653021/2--244050)06055451$+3)0002+215*/5601/1353/5462.3,164.62/34&-*1-,4641615560-6534124+*4,50241422.&56251222-+-450335&210/+11510/$346./2&1/.*05*564-10*0-4,03232,4/4-///1-0/34%00)5-/45+0112255254,4'1))&/102$356521/324441/2/((0.1,#-44461525/-+.000&+4)/043624*262135)246420156246/12043411-1-/.,0+4/56151,56521223151433065315(*'000215513)4540030.1.1/52213,2215121./102)1/%&4)/16.)/2.0/-/+)1+25.134'32%0.221-30*.*0-4200+1310).3/()+0,2.55624+-,&/003,(-/'.-*.//-+0/+.11/+/.1-10/&).)&+.-,+/++),).0/-/%,/1.01---11,+0//./&,0,01//'1,-)#2../1,10-/.+1,01+,00..-1-/0-0*1.2010-''012.211,,'////'010.21/11.-*-,+,&.+%0.+01+0*.*.$+-+21,),/*.1-+.),')%-./.'/0*,-(*,+)-10+)/.+/,,-/+/10111.1-1-*/+,,&,)&,+,'(+*)*+&**($%''*%'#),(,,*-,+(+*'$%#($"(,-+&)*$%)&,-,**,(('-,*--*-+,&,-*)+(()+('()('*'**+-*,-(,,+$-*,.)'$)(+&&-*++-,+))*+(&%$%(,$&)')(%'++-++-(+,(--+$''&(+&#&-,*-+)+,,--)+'$'',+(,-.,)*,,**)#,-(%+()-)&,,.),---)-+*&'**%++*,(-*,%##&&,---,))+,,&*&*(+*(-,,%()&(((+&,*-,**)(')))-))--,))*,--(#&))-*'*&((%,$,-(--)-*%(&,,'*'*-)#++'$#)*&,-*,'*,--,)+-,*'*)&%+-,*.,*(,-*(--)(&(++*$+($&()&,,+,(,&$$*(&*)+-.'+)-..,+.*+,,+)($+(*%,,)&(+-,*-,,(*)'&'%)(,)+-+)(--$+,------)+,(+*-+*)&)#**,****)*&(++*%+(+(&&*%,,(,+(,*),,*,(+((-)-,)&))))--,)(,,-&,,-,&++(-.+,*,(((-,$*+(,--,((('&'#++,*'--+-()+,,(,+.+(''(&&',+''+---&,,,)(,))*((&+,++),-)++**+)+-**(----,',-,))'('+(,*-,,-+)+),,(,,'+)((,.---+',*)-*$+,'+,&*$,,*,(+)+)''*(,--,-,--))),)**())*----,,+-----*((&)'&&%''$$")((*'(,.''$'*)#&*'+*--+('+('-*-,,))-.,*,,,+.-,+-+-)(',-,,*--.-'*(*'''$*,(,+,-*),--)%%'+)*,+,(+),,()()&,,-++,+),-,--,%-(,+%,---),&*+#+.+-+-+-*-+)&',,$,*-,,',*,&,,+++$-+**-(-,,)%-(,*+,)'$***(%"$*(,,*----,),*+)+**+(&)-+(,,),,(,'(+'*'#',---**--+,-),((,-.-*(,-))'&$#'')*&(,.+--,*&(++&)))(++)+*-*+&+,,,), @rCer/1461/1676_60_CCS ATGGGGATTTACCAGAGGGCGCCAGGGCTGCAGTTGCATTTGTTTGCCGATCAGAACCCGAGGTGTGCTTGTGGCTACGGCTGCTAACTGGCTGCGCACAGGGAGCTGTCACCATGCCTCACTTGTACCCAGCCCTTTCTGCTGAGCAGAAGAAGGAATTGTCTGACATTGCCCTCCGGATTGTAGCCCCGGGCAAAAGGCATTCTGGCTGCGGATGAGTCTGTAGGCAGCATGGCCAAAGCGGCTGAGCCAAATTGGGGTGGAGAACACAGAGGAGAACCGCCGGCTGTACCGCCAGGTCCTGTTCAGTGCTGATGATCGTGTGAAAAAGTGCATTGGAGGTGTTATTTTCTTTCATGAGACCCTCTACCAGAAAGATGATAATGGTGTTCCCTTCGTCCGAACCATCCAGGATAAGGGCATCGTCGTGGGCATCAAGGTTGACAAGGGTGTGGTGCCTCTAGCTGGGACTGATGGAGAAACCACCACTCAAGGACTGGATGGGCTCTCAGAACGCTGTGCCCAGTATAAGAAGGATGGTGCTGACTTTGCCAAGTGGCGCTGTGTGCTGAAAATCAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAATGCCAACGTGCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAAACGTTGTCAGTATGTTACAGAGAAGGTCTTGGCTGCTGTGTACAAGGCCCTGAGTGACCATCATGTATACCTGGAGGGGACCCTGCTCAAGCCCAACATGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCCAGAGGAGATTGCCATGGCAACTGTCACTGCCCTGCGTCGCACTGTGCCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCGAAGAGGAGGCATCACTCAACCTCAATGCCATCAACCGCTGCCCCTTCCCCGGCCCTGGGCGCTTACCTTCTCCTATGGGCGTGCCCTGCAAGCCTCTGCACTCAATGCCTGGCGAGGGCAACGGGACAATGCTGCGGCTGCCACTGAGGAGTTCATCAAGCGGGCTGAGGTAAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGTAGTGGAGAAGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGGTAGCTTTCCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGTAGCAAAACATG + 52466/441.565/0.01*366456612262-/4,-52.62451-3656463663.6654455264035+132/+++..*542043445424'5511346661/24644/15-3243.1-345243-12&4054.20&1/00214.43564154534.4-++2.566465530%.123/4566434666(5321220&4+31304464323464646464616653,2140115465//&353/40/004556551343*061204301315634135043564622'3.34(531456665.32*4342645.261.0.6)5412433$45150505..30(0/+3335.4656650-44045,11.064/,15-.//55,45165131(66.0.66663464644.2343032.04604--/41453,4-112/4(/-2)3133*/+%.)/6*.%30254563245)22220,-.,./0%/,/5*25406164426601066444264*03)53/0+,46301315.+,34/510&002412212503/2-146453100/-4114.+&.33)4116240/05*)0325/5401545213631/++'2.2(./253/643430555525.45.5621+.32../'32/&&)536424-)23+,0-4-002/)32/0*541/3/+442/363134432).&10//526/22.02$/53/13-00(-111//2-6665605554)5,543534-34665101441153,2.453.101/1.-*&3235.2363.14'+.40011#)4405140+55412140+5656463251.2462254440..,))-33*36--.-.)2-4615.1035245355..%)1//1.0.000-&-/'..)'&+)1-101112,,010-./++,--1%.1100-022,-0-100-00./.2.+.#*),/*01/211-/1/11-1-*012.1.0-1/-/1%0,'++&.,00/-10--,00-,2-0-./,*0/122-110-20/*/-2/1011-110+---2,'//'12.+,-01+,1,.2/0.121./+&,-.&.++/,,.00+00)/20010/-%.0-0*01.,//0./--+-%10/1/-..0+0..,,1,1.$+/.-0-.-0+0.-+2/00,0*02.010*0-100*0-11/2/).111-001/&,(./)-*.,,,100,,+),0111-1*&*/0-'/1-/1'101)20011,//+,++*/11&,-//0'1/1-1-./&/-/211+)-1)1122/,-.10-,.0-11001,.+.-01,2-,0,10-,10,/1+2/,---202122,/-0*(,.11-+,//+).-(*0-1/011)*-'/'020112.'101*$/00))0./00..10-.1#*)10,,.-'(,/(/.00%+00**+-..--02.*.111(,../,12/1.-+))('/++#&&''','.0,00+((+&)++(-,)&-.)+--*,*-*%((,*,#+'+(,(*,)*++()(,()-&,+-)*,)(''()(,(+..+),('),,),-+()',++*%*,.,,,+)*-+*+-)-+&*&+-,--).+'(%%&,+,,*(-,,-.*)(,++,+''+() @rCer/1464/25_3550_CCS ATGGGACGGATTTATGACGACGAGTTTGATGATGAGGAGCCCCTCCCTGCCATAGGGACATGCAAAGCTCTCTACACGTTTGAAGGTCAGAATGAAGGAACGATCTCCGTGGTTGAAGGAGAAAACACTGTATGTCATCGAGGAAGACAAAGGGCGATGCTGGACCCGCATTCGGAGAAATGAAGATGAAGAGGGTTATGTCCCCACTTCGTATGTCGAAGTCTGTTTGGACAAAATGCCAAAGATTCCTAGAGGGGAGTGCCTGCGAGCCTCAGGTGAACCTTCCTGGAGGAGCCTCCGTCTGCTTGTCCCCACAGGCCTCCAGCTGCCCTGCCCTGTGGACGGCCCATCCCTCCGCAGCCCCATCCCTGCGGGGCGTCTCTCTCTCTACAGCATGTTCCCTGCGGCCCTGCCCTCCCGCCCAGCCCGGGCCACCTCGTGGGGGACAAGCCTCGCCAGCGCCCACCCCCACGGCTCGGGTCAGTCCTCGTCGCCTCCCCAACCCACCCCGCGCAGGCCACTGAGACGGTGGGACACACACCCCGCCTGCTCCTTCCTGGGCCTCAGTCCACCGGGCCCGTCCTGGCGGCCCTTCCGCGCTTCACACAGTGCCTTTTAGTGAAAATGTCATCACGGTCCCCTGAGGAGACAAGCAGGTCCGGCGCACACCAGGCGGACTGAGCACTCGATGTCATCCCTGTGTCCCCGGCTGTCTGCTGTAGAAAACGCTTCCTCTTCTCCCGAGTCTGTGAGGTCCTCAGTGGTCCTTTTTGGATTCTAGGCTTGCACCTCATACTAAAACATTGACCCTTTCACTATCCCTCGAACTGAGAGCATCTGGTGGGCGGGGGGCAAGGTGCACACACACCACAGGCACCACCCACCAGTACACACGCGTGTGCACACATTTTTGGCTTGGCGCCCTGTTTTCAGTGGCTGGGAAGGTCCACGCTGGAGGTCGAATTCCAGCTCGCCTTGTTGGCTCACCTGTGTCCACCCGGCTGTGAGGAGCCCACGCCTGTCCTCTGCGTCACTTCCCTGTCCTGAGAACTGTAGACCATGTGCTTGTGAGCGAGGGCCCTCCTCCCCTTCTTGCACCGGCTCATTGGAAAGCGAACATCCTCTCCTTTCCAGGAGCCCCAGGATTAGCATCTGAAGAGGTTAGCACTTCTTGTTGTTTTTTTGTTTTGTTTGTTTTTGAGACGGAGTCTCGCTTTGTTGTGCAGTGGCATGATCTTGGCTCACTACAACCTCCGCCTCCTGGTTCCAGCAATTCTCCTGCCTCAGCCTCCCAGATAGCTGTGATTACAGCGTGTACCATCACACCTGGCTAATTTTTGCATTTTTAGTAGAGATGGGTTTCACCGTGTTGGTCAGGCTGGCCTTGAACTCCTGACCTCAGGTGATCCGCCCGTCTCAAAGTGCTGAGATTACAGGGCGTGAGCTACTGCACCCCACCAAGGTTAGCACTTTAATCACCAAAGACCCGTGCCTCTCGTGGTCCGTTGAGGGATCCCGCCGCCACCACCCCATTTATCACCTGCTCTTCAGGTCATGTGGAATTAGTTGAGTTTGCTTTTAGAGCTAAGTTTCTTTCCCCGTGTGGGTCTTTGAGGAAAACTTGAGATCCCCTAATCTGTGGCCCCCCACACCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCTGAGAGCTCCTGTGACTGAGAGCGCCACCGAAGCCTAGGGATGGCGTCAGGCGGCTTTATTTGCTTGGCTTTGTAACTTAGGTGGTCCCCTCAAGCATCCTCGGTTTCTCTTGCTGTTTACGACATGTGAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAAGGGACAGAAAGGACAGGTCCCAAGGGATGGGGCCGTCTTTACTCGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAGGGTTGACCACACAGCACCCTTCCGGAGCAGCTCCGCCAGCCCTCCGGGACGAGAAACCACAAGCATGGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTCGGGTTTTTAAAGTGGGTGAGCATGAGCCTCTCTGACTGTTTTCTTCCCTGGGGGACTGCAAAACCGCCCACTGAAGGCTCAGGCTGCGGCAAAGCCATGGGCTTCCGGTCCCTGCAACCCGTGACCTAAGCGTGGTGCACCCATTACATGCAGGAGGACCAACTTGACAGACAAAAGACAAGCTGGGATGACTCAGGGTGAGAAGAGTCAGGGCCGCGCCTCTGTCCCTGCAAACCAACAGGTGCATGGAGAGTGCGGCAGCCTGCACAGCTCCGCAAGGGCTCCCCCACCAACAGGCCGACAGGGATCTCCAGGAACTTCTGACCTCACCAACTCAAGTGGAACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAATGGGATCTGCATGTGCATCACATCTTTCATATGATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGAAAAAGGTATAAGCTGCAGTAATTTGCTCTTTGAATGACTGTCACCCCCAGTATAGGATACGCTTATATCCCCGTCACTCCTCCGCGTTTTTAAATTTTTCCACCACCCGTGTCCGAAAAGAATGTTACAGCGAGTGCTCTTAAATGCTGAACCTGGGTGTTGCTTCCTGGCCCGTCCGCGTGGGCTCCATGGAAAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATTGACTCTGGGAATCCTACTGTGAAAATCATGTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAACGTGGAATTTCCCGTGAGCGTCTCCTTCCTGCCCCATTATCTGCCGGCCTGTCACTTTCACCGCCGTGCTAGAATACTGTTGTGTTGTTAAGATGACTAATTGTAAAAGAGCCTGCCCTGAAAAGTACTTAGAAACAAAATGAAAGAGAGGAACTTGTCCTTTATCCAGTTTTTCATTTGCAGGATGGGAAAGTATAAAAAGGCACGGAAGGTTGTCATGGGCTGTTCCGTGGGGGGTTTTATCCCGCTCACCTTGGAGATAAGCCTGCAGCCTGTCTAACCAGCACAGCACAAAGGTCTCGATGGCTTTTTGGTAACATCTGTCATTACAGAAGAAAGTTTACACGACGTCAAAAAAGTGACGTTAATACTAAGTGTTTTTCCAGAAATACTGGTTTCATGTTTCTTATTGGCTCTGCCTCCTGTGCTTATTATCATCCAAAAACTTTTTTAAAAGGTCCAGAATTCTATTTTAACCTGATATTGAGCACCTTTAAGACGTTCGTGTGTGTGTTGCACTAATTTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCAGTCGCCACTGTAAAGGTCCTAGAGTTGCCTGTTTGTCTCTGGAGATGGAATTAAACCAAATAAAGAGCTTCCATTGGAAGGCTTATATTGACCTTGTAACTATATGTTAATCCTCTACGTGTTAAAATAAAGTATAACTT + *)$((((((&%')#&',-,(+*-''..-**--)+,'+'*&*''++)*),+.++'$+*)*((#*&*)&+'&),*&(&('##(&&'(+)+**'&(*(-,.)*,,&%+('''('-*.,,(&+'*#$*&')*(+(&,-+,(,('*(*$)$##&$'#')'%($$*,),*##$&*)-.-'+*&'*((-,,+')('%%###,()))'()+'%''(*+-+(+-+()(+((,(&*,,%*%'$('''+,-*..-+++(*(()*&)))%$$$'---+)+,+,-((*-+((,+.*-(,'),*$&%*$')(('(%%(+,*))#&)&)))(*),%',*)%&*')+')%'%(((,*)++,')+)(&+,+).*-+,'(')%&#%'#'*,..-)#&*+*(,+%'%&),-+&+-+-.,..+(++,(,+++(&()'#,+'-)&*,-,&$&&()'(),+&(,(,(*)(*)%+,+*,-&,+,+*,*')++)(-+-(')#*('*+)$$)$'&),*$(($+,+$*&,*%$++&&&(+%*)%('(',),)-,*,#+*),)*)'$#***''.))-,'*+,+-(%+%$,%)('%&-)%,%''%))++',*'.-,,$*+'-$%'),*),,,))---))*-$&'((+$'(--,**)*-,,(*#)%&++-+---,*'&+,,$%)*,,**(+,----+*-+&-)(')*,-,(('#$%*'&,)'$)),--,+,($*,,,.--,---+)-),&+#&(''&&'-)*%,(*+$&'--,--($-,**)('-,++-)''-+)+$('($#&$&$%#$$%%&&%#"$&&'()()*',+),(')'(&-*%''')($()%*,),-*---,&+*-)*)--),+((&(&(%#&&%"%#('(+$%('*&&$+*+*),*)%&&(,+*%)&)((&$#&)%*))(+(&)*)(*&-*-*$(%"'*-+)'-+&$%+)&&')(&$#&''(&,(),((*)((,(-+$()--(.(-+-)+),+)&)'+)((()('%$+(($'%%%&$"&##'&&$'**+,,%%&**()+,--)*,)-+,*+-)+$%,&+*+,*$*')-*(**-*+'*'',+-++*)&-*('(*,&&#$&'(,)$(%%(&'"%&#%'(%#()*,(,+&)()$**++,%)+)&'*)(**%((+,(-+-(%%&&%%#&$)-*&'(%(*,*----,,-+-+-,$&'%*)%,*$++++*+,(,--,'-,*(----)),---.-*---,&++-+*'+-+--*,+)+,&+,**&(-%,*$',+++-*-(+,%&),,$).+#+%*,-*)(%(+.-+(+,,(*++*,,-)*,-*-+(+++(,,-,-.+,,'))(,(+-.,*&,*,'-,,-'%%'&*,+,+-%&--,-',(,()')+$*(&+-)%%+(,-)+-.-*)+(&+,))-&('$%&((.,&%(+,+*',,--)'+*+,,'(&*+'&(++)&,--(')-+-*(*)-,*,+*+((*++*+%,*)'+)-.-+(+('(&$)-.,.*+),+%*'+*$,,*++)-++-*,(,-*-.-).)*,-,++&&(&$(,(-'121*101+'00+.1,02111.102-/,1-01011-0(1(,+.)0,/,(0/)/,0221.100-10.,/1*%,/+..1.110.20/-022/1/212001*/-/0/-'0.-/.1,/-01)0'-0011101../211.)+-0+01-0&00/-,+/-0/1,1/02-,110$.-,/0(+000.'-.00.1'1,/,)11.111112110*-/,.,,&.,.,/-)),-/0&-./%-,/0+#01-01,,,02-,1*%&01/1,0020+0110/.%*1,-..-0/%//-.-+/.++,-2-1++&0/-10)1/...+0.-/1(#(./111100..10.0))-../1,0*/002000./0//',-2/**,10-)),.10-**-)1/.,1,(/.0*./1,/.$,*,,/1.1-,+.10.1,0-00*,10*/20-)-.--2--001.1*/21/--)'))01/,()-*)'-*,((+/0-*,,'./1/++1/-00.001,,,)-//-(,120.-/*,+*).22/+*&,+,+*),)+*-./1-,,,+1.,1-(111.'(+&.(-0%#%'#"$&%.0/0101.011*+%&*)+,+'0.*&*('''),*,'.,#)0-)/+%)(0,-+1-.-%%**10.121.02/&)),021,)0(1,.()201/1.2(.*,(,.-/-,.(+')'+*++-,/0--21.+'+-$*&+(*..2120---,.1/01/,.0,01,0,)0/2,,01--1/,.2.-01.,.*(/,--*..*1',/.0/+'/1-//,***.+--+++***,000,-/.-100//*2/,0+0,0,,-0101*.-.%-.,,.*%,-)+))*+1-'#.(*'(-*%($%%&**1+.0%(+%**&*(.1)00-2.0**.),*(&&$&$'.1-1,,2.1+1201++1.1111,000/-2-1/,21,1.21122/11,01..,.0/1-/0,-0/*+,-,01--,,,00110-.,,..0-,+,*1-/00-/,.-*$.,-$)/./.'/)+*,..*.-0/10.-)++.,*/)/.+/2/....0010'.*1503,-2('(**4662-23534.45500/350/--$.2,3&1.33,21$2432/42)-/'2.../2-00///52*/*/,,,-*(.0/230(-),3)555340/352/(.)313*/-0425565612/0%-14530#/),%(.0,--+'.///13.*//..--.,*$)1-'+/&//%/,+(-.&+))),/+/.0-.)+),')./43604556203150/00,/1,13-#*#%+425523022/,10+1*-'.04145/25+/-+-)/),+*%./21...4,234664312,00,-2.0(-%)/1+3435%)*,0.(((##%*003,,&$+*-$'1*-2204/04005.,&$+(*./,-22*/,..,/1*0/,/0.0,/11'0140450-31/23012+'('1)-*(,)0)&*1*''+.230.),-0.064243-25514441&,1.33*.26534060-*5/*-/+)+1+0015400*312-3,/(./,-,.)*,-'-&-*.-$)+0//3&/01152--011.1/,(-(0-44.&*)+..&$,.)-,+/-./4.220+3113634261563.0330//53%222/.33)30/4-4465446441/+10*223(461121/.+$&),,0.31+10-42/2)0,-..'+-02-0425.516414*)'1.11052(232561.4004$-0-,0/)/*,4/1+../12'3044,111/303.(('/0-...662644612-1-/%-/%.,/-+(*.-,&+&*//,01/2(53365-./+4534045210(.004233&)&/3++55(41130.3(3)41222$*51.055616102..,045146166142,23432//15-445%35332.0456041,03-3&4,5534/5/,+5542546646606240234113/41+/-0.,'(***00+1/0-.4,'2,+32.4,213/0001...).-*(*-,/135 @rCer/1465/1847_54_CCS GACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGTTGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCG + %KKKKKJKKKKKKIKKKKJKKKKKKKHGKKJKKKKKKKKKKKKKKEKKKKKKKFKKKKKKKKKHKKKKKKKKKKKKKJKKKKKKKKKKKKKKKIKKKKKKKKAKKKKKKKKKKJKKKKKAKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKFKKKKKKJKKKKKK=KKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKIKKJKKK**8KKKKKKKKKKKKKKKKKIKKKKBKKKKKKKKKJKKKKKDKKKKKKKKKKKKKKKIKKKKKEKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKDKDKKKKKKKKAIKJKKKKKJ:JKKKKKKKKKKKKKKKKKKKKKKKKKKIKKJKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKK)KKKKKKKIKKKKKKKFKKKKKKKKGKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKJKKKJKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKGKKKKJKKHKKKKK@GKKHKKK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKIKKKKKKHKKKKKKIJKKKK3KKKKKKKKJKKKKKKKKJKKKKKJKKKIKKKKKKKKKKKKKKJKKJKKKKKIKKKKKKKKKJKKKKKKKKKKKKCKKKKKKHKKKJKKKKKKKKKKKKKKKJKKKJJKKKKKKKKKHKKKKKKKKKJKKKKKJKKKKKKKKKKJKKKKKKKKKKKKKKKIKJJKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKJKKIKKKKKKKKKKKKKKKKKKGKDKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKJKKKKHKKKKKKKKKIKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKJKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKFKKKKKJKKKHKKIKKKKKKKKKKKKJKKKKKKKEKKKKKKKKKKKKKJKKKKKKKGKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKJKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKFKKKKKKKK5KKKKKKKKIKKK9HGKKKKKKK*KKKKKKKKKKKKKKKKKBKKKKKKKKAKJKKKKKKKKKKKKJKKKKJKKKKKKKKKKKKKKKJKKKGKKKKKKKKKKKKKKKKKKKKKKKKCJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKKKKKKKKK?KKKGKKKKKKKKKKKKKHKKKKKKKIKJK@KKKKKKKKKKDKKKKKK)KKKKKJKKKKKKKKKKKKKKKK1KKKK/KKKKIKKKKEKKKKKKKKKKKKK8IKKKBJFKKJJKFIGIFJKJ7KJKKIJD??DJKFJJKKKK5KHKGK7J=IKKGFFDI'IGHCK@:GK@FHKKKJ?KH?HI=KKKKJ4KJIKKIGBK,KKKHIKJKHIK.KKJJB>KKJ>BKJIIJK7KJKKKKHKIKK=KKKDKKKKKKJKFG>KKJCEFJKJJGJ>IKJHIHHGICD?I8KFGEKKKKKKJK?F4HIKAKKIJJKK;JKKIKKKKJJHJHKFKKKJKKKKKEK9KKKIKGJ;IKK?KJJBKKIKJKCKKKKKKKEKFDKKKKKJFKKJKKJJKJKKIJIK0EKJJ=9GKKKKKHJKKFKKJFKDKHKKJHKKGKKDKGKHJKKCJE5IKJ7?8HBKKJJKJGJKJKKJJ@KGG30?KKKKKIIKBJKIEKIKKAKKHKKJIHKIK@KIKKKKK3KJKKJEKIIIDKCJJKFKEK=K?KJKIKK(JKKKKIHJIAIKKKKBKKKK4D>FDJKKJII>KIKKKKKKKKKKKKJJCKIJHJKHKKKEKKKJ=IKKF;KKKKKKJKGHJKGJKKKKKJJJKI?IFKIGKG;JFE:KJ:KKKGGG@HFIIKKHEJCEIJFKEFK>JJKKKGE<@>75)FEEHAFJIJGHAE#JKKKDFJIHJKKKKKKKKKHKJKIKKHE:KIJ7KKK@IKJJKKJJJ?IEKKHJKKJKICKDFKJKIKKKIKK3K;KFJKKJKHKIJKIKKJDKJIG?I8>KJFJJ&KKFKKEKKKKIJ2CIKI@KG9IIIJFGJGHHFJKKKKKIKKKKFK;KIHKKAKJKKHKKJKKKKKKIKJK(JKKK?KKKKKKJKKEKKK@KKKIJHICKKKKKCJIHKKID;JHH)KKKKKDBKKKDKJK7K9KJKKKK)JKKKJIKKKKGHKKKKK@KCJE8KKKAJKKKIKIK.IKKJ@KKFFJ>DJKKKFKKJHKJKKKKKIJJKKIIKJKKJKIGKKBKAJCGJJKKDKKKJKKKKKKEK?KKK @rCer/1470/1678_59_CCS ATGGGCTTATGCTCATAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCCGCAAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTTC + 03/2)43/-514541$213.02001132122&+615660/0242*155420*403'441213231,114666+24241031303'315/5645363-%3/442%34206406261560651/3366/4432-56/341)+-0(*+*)45325+5500/-50.3530.,-5.5261-1,236203+53.2-../.-),&.(/-104'352.41/44,/.100$32,,1313200344(5236606.-,/)+,40,.423'1/)*1-2552110312&24.4-00/,24/20,)./-362421-52454330&0/-)444.1/21-,'3(066,41/+/*,(1,)*..0144,11/,#)%+0.434500((.,01.013++(/344//4.,33233-)/10&160556142..,*0-14,06524454-062-)3-0//+3'354054164301524/*-/,0,0304/4544-41,-.,011)36/*26.1342,15450-).5045-5445-04/32'266,/-20/(343($/-30.&0(15222/*046053'04,./0,0,.-03/534+.*2/++,0+,).4.,-/3,3221054321554+0/)3+55/1+,1430*.632//-)01/03/.%,-5412112#-.301...335433.365242532100%4431001*.,(/1,-0.203401-263.05243366*5.5.,01/02.)/.-).4/20-,(01)40)&-0'+0-61/2334)01-.(15-$+*(-&.2,4/'144/402,--1-.*+)&-/.--0$20+.'-12(+-(.*')$,+'-)/01/*&&.-2(.46.42446,-/%3/56542))0/223(4603+344.562+160/2.414005505456.'(+/./5/34/,1*--05533-112/2%25/504'150.10,*3,45-0.-)1-+356455*50-54*')'03443*3(0/3.13.2/2)1/10.3502/25022/443-14,1/.,/12&04,1'/52012$1-14300/6256500153.40343301451114/26.1*,,03/6)510/-102)1&000'-445432*4//-42+4132/4245..54131146/'56521(4343-2/31'/04033230321322.202/,044/,.534361/40-'&+0/0)34-/12521322001)/+..%&.&//1//&/0/.,/11.,0/2.0.*..000.1+-1,020+/,2,++/0/.00.0/+,,(*1.-,/00'12-0,,0.*.01(////.*-,,0(*)*/2./++..0..,2.,--)$,-+*-/+&+2//.1-0+21.1-.0.-.'/,2../111,.*/+----/.1*&*.'/0,)(%(&0/.0)*(,-0+&&.0*(',-.(/00&%%-2/-/*.0,./,-/&0.+0-+0./#()+$./00)/0++0,0.+/-/-,)(.(,0-02*,0.'2,1/*0)0-0+./..'.-+//+,0--,)++*/-&*-)0./,(00+**1+))'(%0(1..,1-,00.0'/0&.0,,.(,.-,/&,)'0.&/0*$//&'//-$')-/.&/,2/0/+//)02.//00/,-010220/../+10100/'/ @rCer/1471/0_2742_CCS GAGGGGTGACAAGAGATATGGTAAGCACGATGAGCGCTAGAGAACTGACTAGATGTTATCTTTGGTGTTTTGGTGTGGTATGGTATTTGTTGATTGTATTGAGCCACTGCGAGACACGAGCGGTCTGCGCGGAGCTACAGTGTGAGTAGGTATCGGGTGAGGTGGAGGAGCGCGCGAGAGAGCCGAGTGAGCGGATCGGGAGGCGCCCCGCTGGCCCGGTCGTCGCGCACGACGTGGACGCCACATGGAGCTGCAACATCGGTGCTGCAGATGCCTGCTTACGCACCGTGGCCCCACTCACACAAGACAGACATGCGAGGGCACGTCACGCGAGTAAGATGAAGCATTTCGGCGAGTGGCGGACGTCAGGGGACGCATGGGTATTCATGCACGTCGCCTCAGTCCGGCTTCACTCGACGTACTGCAAGACTCAGCGCCTGTTGTCACATATCTCAAGAAGGAAATCAGGCCCCTTTTCGCGTACAGGCAATGCAGACGCACTGATACTGGGGTGGGGTTATTAAAATGAGATGAGGGGGGGAAGCGGCCCTGAGCGGCCCTCGTGCAGGCGCGGCGCATGAATACCTCAAGATATGCCATCGCCCCTCTGCGCACCTTCCTCCCGCCATGAGAATAGTCATCGAGGGCATCCCCACGAGCATAGTCTGCGTGCGTCGCTAACCACCCACGGGGATATGCCAGAGTGACGAGGAGTCATACGAGTCTCGCTCTGCACATTCACTAGGAGCATCCTGAATGGGGACCTGCCAGAACGGCTGATAATGTTGGCTGAAAACACTGAGGAGCCAGACGCATACTGAACGCGAAGTGGCAGACACACACAGTCTAGCAGTGCGGTAGAATATGAACTTGCCTGGCCACCTCATGAGCCCCCAGAGGTCCTAAGTGGGACAGATTGCTGCGGGGAGTCCGTCGAGAAGTACGACGGCACCTTGGCCTGCCTGAGACTAAATCTGGGAGGCCTTCCCACACCAAAGCGAGAGAGGTGGGGTCCTAGAAGGCCCCACCTATACGCACTTGCTCACCTCAACACCACTCGTGGCTCGTACCGGGCCTGGTCCATTATGGGTCGGATGGTTCCGGGAGTACCTGGCTCCGGGTGACATTGCCGATTTCTAACTAGTGAGCATGACCATCCACCAGGCGGGGAGAGGGGCAGGCCAGGTAGGCAGGTCAGGCCTTCCAAGGGTGAGGGATGTTTGCTGGTTAGGGGGCCTTCTAGCGCCCCAAGGTCTGTGAAGCGGTGCTGCTCTCCTGGAGGACTTTCCTGAGGAGTTGAATGGCTGGCTTATCAGCGGTCTCGGCTGACCGCTTCCTTATGGATAGGTCGATCGGCGCGCGGCACGCGCCCCTAGCAGATCCAATGTCTCGCTTGCGAGAGAAGGCTCTGAACAGGGAGCTGGGCTATACTCCGGAACCGATCACTGAGCATCTGAGGTCTGTGGTGCAGGGTCATAGTGCATTGCTCTTGCATCAAGGGTATGCGTCTCTGGTAGAAGCCCACGCGGCTTCCTCATTCCTTCCCACCTGTCGAATAACGCGCATCTTACTGGAATATTCAGAGGCGGAAACTCACACATTCAGGTGCATACAACTATGGGCCTCCGGTCGCAAGCAGGTCTCAAGCGAGGGCATGGAATCCTGAAGGGAGATGTCATCTAGAACTTAGTGGGGAAAGGAAGCTGGCCCAAGCCAAACTTCACACTGTAGGAGAGCTGAAGAGTAAAGTTGAGAACTACCTTACAGTCTCTTGCACTTGCGCAAGACACAAGGGGTGGCTTGGGCCAAGCTATTTCCCCCAGTCAAGGACTCCAAGCCCTTGACAGGCTGCTGGAGCACGGGATATGTTAACCTTTAACCCCAATCAAACGGATCATCAGTGGAGGAAGCGGCTGGCTCCACCCCTACCTGGGAGCAGTACTATGACACCGACGGATGAGCCAGTGGCTCGAGGAGCCCTTCACTCGCCAAGGAGCGGAGATGACCTACCTAAGGAGCGCTGAAGGAGCTCATCTTCCAGGAGAGCAGCACTGCTTTCCAGGCCTGGGGCGCTAATGAGCCCCCTAACCATCAAGACAAACATCCACTTGCAACCCTGGGGCCTGGACTGCTTGCCTCCTGCCTGCTCCCTCTCGCCGCCGACTGTTAGAAAATGATCATGTGACGAGCCGCAGACATTGGCAAGCTCCAGCCAGGTGGAGCATGGGCTGGCCAACCTCTCTTCCTTTGCTGAGGCCTCCAGCTTTAGAGCAGGCCAAGGGCCTCCTCCCCAGCCGGCCCTGTTCCCACAGGACCTCGGGGCTTCAGTGGCCCCAGTTCAATCTCCCACTGCTGCTGCATGCACCATTACCTTCCCCCAGTGTCCAGTCTCTGGGCAGTTCTAGAATGGGGCTCTGGCTGCCCTGACCTGCTGAGGGGCAGGGGTGGAGGGTGGGGGCGCTGAGATAGGGGACTCCAGGGCCAGCCTGCCCCCCTCATCTCATTTAACCCCACCCTATCTCCCTGAAGGAACATTCCTTAAGTCCTCAGGGCTAGCATCCCTCGAGGAGCCGGACTGGGCTGAATCCACTCCTCCGTCTAAGCTGTCCACTTATCGAGTAGCCCTCAGCTGCTTCTGTGTGTGGTGAGCATGAAGTGGAGCTGGGGGGCGTGAAATCCCCAGCGCCCTGCCACCTCCTGACCCATACCTAATATATATAAATATAGAGATGTGTCTATTGG + !#####$!$#""####(+,(+-''(*&)$$'$##)'$'%%&%")##$(')',+++)**&)(')#(+(*''+%"'%(#'(')'%*)((((((%&%())'(*&%(%'#(+)%&&)+&(+&)(,(&))#'(&(%#'&)()*,+"+()),,**,+&#+$$&$&'''*'%*#'#)('(&)%#'&''+(,*+++#(%-&&,--)**(,),+#&)+*(%'#'&)&(***+#$($()*%(-,-+%++,)-&+,%*+#+,-,,*'(-#,++-%,-*---#-,(*++,*+*(,)&'-(,(%##%#(')*(&-,%-.+)-+-.*#-.,('*%,(-,--..+,,---$.+-..(.-.),((),(.)-(*+''++,--..,+(*'*),))'%)+,'+..//.../.-.+'-$+%,*'*-*-+-+''---,.-**,*--'.,.,--,+-%$,)$'%'#%$$%"#$&!%##'$#)),%*.-)**'#',,)'-,*)))&'+,)-",-,-,*,,'+),-.-')-.*(),-()$,)++(.'*#,-,'*-,&,%$###&&'($,+)%'++)%(+,)%))++,)*+*&*%''*$*)))++#+-)),--#++-,','(-#,++&''$'-+--&-,).$*$,.'*,-+..-,+)(,.%,-.--.')%%%,+,$&&+*+),'&'*)+,+*+)*))-*,,,,,#,)-(%),&"*&(+),,"((,)-,,.*+,,+*+--++.+--,--)(-+.-.--)*"/+(.-...--(-&-).*.+,&',%%')-$-,*$)'+%+%#),+')*"#$'*++*+-,&##-..&*...,..+/.+..'-.-,..-(+-,--'-)(($----.(--+')$)##$*,-,,--.-+.'.(./'..$...-'(.--&$,+(+(&,-*&,$)$*'#(((,-&,,#+,,&#)*%*-*",//../,&$*(,*(..,.-)'#,-),-+'-(''((--+,'(-*,'++)&($+(%%,+*()(%*')$,',*#&%$')#)'*,,,(,(+)+,($&(,-&,+)-%,-)%'&,+%*(%+(&+))*+$+++$(%&"+#**+)'*(--**+)----#-*-$'#'&,#++&(++*++)')%*(((,*,#*'+$##('&&'--)',.%-,*,+*--/,+,&.,-.+..-%..+--.,.*///+.+."'%+(%)-.+/%&*+.+(*'+(.&/,+/...$..,/+...,),+).+$*.*#+*,(,&%%((-+-(+-''*')'-"'&*)&-)#+.../.))*.#-+*#...$/*.+/,-/../.-.+.'..(')**%-,#+(--)-+(--'),",,+%++)&,$'&+,'+(*)",..-(-**+*-$%&$'-,-.%',#--,,)-'---#',*+*,+*'&)&'(%%&+'(*,+-,(&*$%+)*$()$,#)+,+*()+'-,(,-,--+"-,+*$(+-,*(&,,-.-(-*&%*%-*.--.-(-+,&++'***$((*+++--+--+.#''+---,..*+-&*)+()%"&&(#%$#*$(+,'--..+,-.-*+)*(',-&+-+**#$()&+'((--),',$*$#'$'-,,,,(&+-'"-++(+#,,)---,+,#,&,+--#''+)-*+$%+('&#$)(+*,,,'*(*,,,&&%($)(((")&+,#+''$)#-%,+*,,+$$+&%'%-%)(++',,(,#%-'---(,**')++$&%$,*-,,-#-.-...-*%,-+).)))+..+)*+'.(..*.#,$&$)'$$%*$"#"#"&%##$,$+##%##%#"%##$#"#++*&*.++--..*,--#)-'$+'#%'*-(-$),")(.($*)-+(/,&(+().%**-,++)-#%%)'&,$'#,+'%)-*-(.-)))))(,*$"&++).-*+%-,#.*(&..',.,+(.*+,*-+%'&$+&-,'%'..-,.*..#//-,*)--(+#+.*(/'-,..*/-())-..+,.'*&(-+*-+.(.&/,-+"%-*./-.&/...+/.,&,+.%*-.--.+)+.&,#-*&)-*/#-.,..*%&&,....*+-.+).%..-.*//.,.)..-..,.-+--)-'*..,.&.(.&.../#.-,,#(.-'"&..''+*/'(-#,#-'()%$(-.(.,&%"&#,.&+*%'-&-)'$&*+(.,$*+./,*-()/..,(,"#/.#.)./&/..',..,#)%,/-/+#,/.,/)%..-%*#(#'&&.'."/..-,."(,-'*.&-)/'-$)-.+.#)+,"'.--,/*+-.*(...//,-*/.-(*.'%+.,...+**/.+...//+.),%/+/../-*,.,&,/.+++/)/-)')/*'./(%,../,/-)(&.*,'('-'../,,*,+*.%)*+.-"/.)-,+&)*'&.,(+&/.-+'*++&///.*/+//"+).&(*#-)-%)+-'#*&.&..-..)//.-...(((-)/,+/...%..'%,+.,/.-,/.-$)./.*.&././..**-+,.-*,+.,(.+(++*)(,**.*(,..%..,*')../&/-,,+(/./+//.()()'-..,-%./.,)-).*($**%*,.....(+/./)/.-*/.%*.-%-.%,'.(.'/*,-+++../+/,')#...,-..('..--/,*)///)..*-"-/(,"*...(")..-/..$.*.).$.+..).#-,',,.).---.#--..*..//,..-)*'-".',-.*'....+**$*)+-*-*%&$(&#+(,,,&),,-)-+)&&%&&..('-)+"*)+(./+.+/'%$'--*&-+..//+,..'.*)*,+ @rCer/1474/25_2129_CCS ATGGGGCGTGTGAGCGATAAAGTCATGATTCCCCAAGATGAGTACCCAGAAATCAACTTTGTGGGGCTGCTAATCGGGCCCAGAGGGAACACCCTGAAGAACATAGAGAAGGAGTGCAATGCCAAGATTATGATCCGGGGGAAAGGGTCTGTGAAAGAAGGGAAGGTTGGGCGCAAAGATGGCCAGATGTTGCCGGGAGAAGATGAACCACTTCATGCCCTGGTCACCGCCAACACAATGGAGAACGTCAAAAAGGCAGTGGAACAGATAAGAAACATCCTGAAGCAGGGTATCGAGACCCCAGAGGACCAGAATGATCTACGGAAGATGCAGCTTCGGGAGTTGGCTCGCTTGAATGGGACCCTTCGGGAAGATGACAACAGGATCTTAAGACCCTGGCAGAGCTCAGAGACCCGCAGCATTACCAACACCACAGTGTGTACCAAGTGTGGAGGGGCTGGCCACATTGCTTCAGACTGCAAATTCCAAAGGCCTGGTGATCCCCAGTCAGCTCAGGATAAAGCACGAATGGATAAAGAATATTTGTCCCTCATGGCTGAACTGGGTGAAGCACCTGTCCCAGCATCTGTGGGCTCTACCTCTGGGCCTGCCACCACACCCTTGGCCAGTGCACCTCGTCCTGCTGCTCCCGCCAACAACCCACCTCCACCGTCTCTCATGTCTACCACCCAGAGTCGCCCACCCTGGATGAATTCTGGCCCTTCAGAGAGTCGGCCCTACCATGGCATGCATGGAGGTGGTCCTGGTGGGCCCGGAGGTGGCCCCCACAGCTTCCCACACCCATTACCCAGCCTGACAGGTGGGCATGGTGGACATCCCATGCAGCACAACCCCAATGGACCCCCACCCCTTGGATGCAGCCACCACCACCACCGATGAACCAGGGCCCCCACCCTCCTGGGCACCATGGCCCTCCTCCAATGGATCAGTACCTGGGAAGTACGCCTGTGGGCTCTGGGGTCTATCGCCTGCATCAAGGAAAAGGTATGATGCCGCCGCCACCTATGGGCATGATGCCGCCACCGCCGCCGCCTCCCAGTGGGCAGCCCCCACCCCCTCCCTCTGGTCCTCTTCCCCCATGGCAACAGCAGCAGCAGCAGCCTCCGCCACCCCCTCCGCCCAGCAGCAGTATGGCTTCCAGTACCCCCTTGCCATGGCAGCAAAGATCCCTCCCCGCGGCGGCGATGGCCCGAGCCATGAGAGTGAGGACTTTCCGCGCCCATTGGTGACCCTTCCAGGCAGACAGCCTCAGCAACGCCCCTGGTGGACAGGATGGTTCGGCAAAGCAGCCTGAGTTATTTTTGTGGACGGAATCGGAACACGCTGGCTCCATATCGTGAAATTTTTATTAATTTTTTTTTCTTTTTCCTTTGTTATTTCCTTATCTCTTCCTTTCTTCAGACTCCGTCCAAGGAGATGCTCTCCCCGGTCTTCTGCTGCAATTAGATTCCTTTCCCTTCTCTCCAGTTCTCCTTCCCTTACCAAGGAGAGGGGAGCAAATGGTTTTGGGCATGGGCTGCAGCCATTCATGTCAAGCTGGTTGTGGCGTTCTTTGGTTCTAAGTTTTTCAAGGCGCCATAGCCACCCCCGAAGATATTTAAAGTGTGAGGTTTTTTAGTCTCTGCCACCCTTGTCAAGGGAGTCTTGTACGGTTGCCGAGGGTAGGTTCATTTCCAGGTTCCAGGATTCCCATCCGCCCTGGCGCTCCTGCCAGCAGTGGGTGGGCAGCCTGAGCTCCCTTGGGCTCGCCTGCCAGCCTGGAGTTCTTCCCGTGCTCCTTGACCACCTGAGCTGCCTCAGATTCCATTTGGTCCTCTCCTTCCTGGAAGGCTTTCTTTTGTGTTTTATTTTAATCCCAAATGTCTGAATGTTTTGCAGTGTCTAGGGGTTTGAGCCCCTCGTTTATTCTCCTTCCTTTTTCCTCCCGCTTCCCTTTCCATGGAGTGATTATGTTGATGATAATGTATACTGCGCGTTCTCTTCACTGGTTTATCTGCAGAAATTTCTCTGGGCTTTTTTTGGTGTTAGATTCAACACTGCGCTAAAGCGGGGATGTTCCATTGAATAAAAGAGCAGTGTGGTT + CC?JKKAI;HGIEFJJIH=IIHDKKJJJ8I8KKHBKBBJKDHHGBJI8J@JKBJ@KB'?@CI;>JKG?JIFHJJEIBH;KJHCH6>HEA;G5EHID7HKJJK?FIIIH=JKKIK-KDFKDKHHHHHKJAKKFKH4IIKKH=HIGK:HIKIDIIKCHJJJHJGG+KIDJ<>HCF?KCCFI9IDHKJJIKJF*FA@DDJAFIKHKCKKGFK>I>JCE@CEBGKKJKKJJI@E.EJ@BII;FFGK>I@?JGHG@>GKJFJ;GAGDCK6IG;GFKJJEDHIJKK4KGJAIJJ9AGG?KIID@IDCBHICJIIKDKIG8JG?JFJJJ>E<KK>IFHJKI>GBBE7B<B7;EIJJI7FDK'JKCHJKKKG?FJII>$EGJGKKKJIIIKKBI;A?>>H@8HCJHIIKKKKIEJGII+JKKIJ6IGDHIIGKAIKAKKIJDEIKBBIHFHEKJJK@=?@IGGDDKJKJIJJJHIJJKJHK6HGDIJ?AKBJACGHBGJ:E?HHFJG:D,@2AD?AFB7FHIJ6CB5GCBKBBIDBHKFIHFJKBKI;EC<@48G;FKIAA?:IFJI9>KJIKJ(K@@FJ=H;EJKBHJKKH@KFBIBJGD9IJIF@7GIJGIK=KK4J;IGKIHHEKHI@FG&:8:2?DAH.?FDGCGJIJDDEJEID@GHB;JIH4HCJ?FKJAIKGEAIKKHBKHEKJJFIGJJJJBK;JCHGHJFGJKJJEKJDKHKKKDIKKKHK8GJK6G2KIHKKKKKKHGKK4JHBIKCI?KF*IJHI?DJJH2HJKJKKJIF2GKJDCJKHGIKGDFJ,FDGIJBKJGIIEJGBJJDGKJHKIJ4KKKKKIG=A9EB8CH?3I9?KAJIGK=IK??DAEIGB>JJEGKK:IGH;FKHKJJIKKKAKKJJK@JFKKKK3KEJK:KKJHGJJBJKEFKKJKKJKEJJKCKKKKK:IHIIKKJJKIKIKIKKKIKKAK;KKFKKJKKJJJKKKJKKKK@JHKJ?K;KKKHKGKEKJKKKKKEKKKKKKJKFKKKIKKHIKKKKJJKEIJ1K @rCer/1479/1825_65_CCS ATGGGGTAGTATGGCATCGAGGAGAATGGAGACCAAACCTGTGATAACCTGTCTCAAAACCCTCCTCATCATCTACTCCTTCGTCTTCTGGATCACTGGGGTGATCCTGCTGGCTGTTGGAGTCTGGGGCAAACTTACTCTGGGCACCTATATCTCCCTTATTGCCGAGAACTCCACAAATGCTCCCTATGTACTCATCGGAACTGGCACCACTATTGTTGTCTTTGGCCTGTTTGGATGCTTTGCTACATGTCGTGGTAGCCCATGGATGCTGAAACTGTAATGCCATGTTTCTGTCCCTGGTGTTCCTGGCTGAGCTCGTAGCTGGCATTTCAGGGTTTTGTGTTTCGTCATGAGATCAAGGACACCTTCCTGAGGACTTACACGGACGCTATGCAGAATTACAATGGCAATGATGAGAGGAGCCGGGCAGTGGACCATGTGCCAGCGCAGTCTGAGCTGCTGTGGCGTGCAGAACTACACCAACTGGAGCACCAGCCCCTACTTCCTGGATCATGGCATCCCCCCCAGTTGCTGCAATGAACGAAACCGATTGTAATCCCCAGGATCTACACAATCTGACTGTGGCCGCCACTAAAGTTAACCAGAAGGGTTGTTATGATCTGGTAACTAGTTTCATTGAGACTAACATGGGAATCATCGCTGGAGTGGCGTTTGGAATCGCATTCTCCCAGTTAATTGGCATGCTGCTGGCCTGCTGTCTGTCCCGGTTCATCACGGCCAATCAGTATGAGATGGTGTAAAGAGAAGTCTTTCAAGAACGACGGAATAAGAGACCTGTTTTTAAAAAGGAACTGCAGCAATCTTTGAAAGACTTCCAAAGAATGTTAGAGCACAGTACATAATACACCTGCCCTGCTCCCTCTATCCCTTACCCCCCACGTGCAACTGACACTCCCACCCAGTCTCTGCTCCACCTTTCAGCCCATGTCACTTGTAGTGTCCATTTTGTGAAGCCTTGTTGTGCCACAGAGTGTAGCCAGGTCCCCTTGCAGCTAGTCCTAGTGAACCTCACCCCGAGGGCCCTGCATGGGCCAGCCCCTCCATCTGTACTTGGTCCAACTGCAAACTCATCATCGGTGACTGGTTATCACACCATCGCTGGCCCCTTTGGGCCCTGCATGTAGTGTGGGAGGCTCCTGTTAGCTCCTCACTGTGGTAAATGCCACACACCTTTTAAGTAGATAAGCAGACGATAATTATCTGTTCTTTTTGACTTAATCTCATTTGGTTTGATTTTCCTCTACTAAGGCTTTCCTACCTTCTTCAGGCTGCCTAAGACATGTAAAGAAACACATCGATAATTGTCCATGAGGAGAAAAAAAGCATGTGTCATGCATGAAGGAAACTGAGCTTTAGGTGGCCTCCTTGCTTGTTACATACCTGGGTATGTGTAGGCAGTTTAGTGCATCTTTGCCTCTCAGTTGAAACCTGTATAATCCTGTTACAAAGCTGTGTTGTTGCTTCTCGTGAAGGCCATGATATTTTGTTTTTCCCCAATTAATTGCTATTGTGTTACTTTACTACTTCTCTCTGTATTTTTTTTTCTTGCATTGACATTATAGACATTGAGGACCTCATCAGAACAATTTAAAAAATGAGTGTGAAGGGGGAACAAGTCAAAATATTTTTTTAAAAAAGATCTTCAAAAATAATGCCTCTGTCTAGCATGCCAACAAGAATGCATTGATATTGTGAACATTTGTGATATATGTATTAATAAATAGAGCAATTACAAG 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4352,00220445*55/0/*'(0/..4.121/4,1/&32,.*3425*2/12/$,,235'33)15031*364.552/46350/1(/612644./61403521310'2(2666552111/1*205205564-22'25.2534410*551*140$25155-6355001230*50224-3243/34456501464632--1,0**0,41632-1/54354*54230044+4+.%)-/0)4,163536*/04.0420,30(4'-,/32*35614414146322+2./'131,/.(33'41506.026225314256/41345646155450646255,*.535552*3/.45/52/054-10130402/551600*33-3610153/2114354/4,1.)41111(...560/0(5266-+0130/0.-.3433./5345323+--.+*($0/30$.1312-*2113.50-,0+1-1+3621.1,+*13311*03,113402666541.42+3,0034461$1-0-).521664423$14.1.)%1263.-55,515653//1,365/13**-2414.'431511,,,5465465460,05650.1$3,+321536552-25141541//434035/3133./-3/5610501)55165.1*24/.141*6123+1*42201111066202.+32/1(-*-)3-6)62).3/',436115544634+354455.25632-/0,23,3.//.153031534444/)-$46*563443)36/3)2'10,///12.2.35*0*3453132200$2321$1.5431340/0656425'023.4.&6/5536554-.-0*.2*34122,,1/244)531155646554625664365/534-1)'3414/01/31,+62+4531',)32-01212*44,666645,(6344*54152+0)44110246--54422)/220$--25/423/'4531,5453.0324,33142//6432661.)3,/*452/1312646362643//./2'21+1%44-264303506443654,464131413.22)/.32260342/-+%/2541*.-+/263122/.5.4664652/%4164662666056335065324+3).42366465214121612.2'302*14./4/14/5056544665364-,/,*2.&4+6543.561.20441564655*232331(22112)3/3515-$/*-222$3266,214/0(5%2221522/4+056-5110543120*20.-3/22*02)-/561115,'-22'423.10-21401-./215-40./.(025665%51245121.531.-*4441166051/$4666-.//310016340+'45.16/641.3004420561466425/,1445.56452/-45301401/24511$245(634*%0644654534//,+*$/566655124.415.6502315165621///444230.4646,4661..-+1/1.0)(.-+/)+2,,1/*(,.'+01)//,)-//+-0/10-00.+,/*/+(1)$,0-/,.1-%+,.0'*01+0*0-.)-++'0*&0*12,)-**(#'-,)..'02,)(*((/,*.)*%+11/&'.*,,011()+%##$,+112000101,.-&&+20011001//(..*((,*('-./,%/-+)/-10(*0(110/'.*,,&00.-/*/*111120.*)+0+01/--)*'/-**0'- @rCer/1480/0_392_CCS CGAGAAGGAGATTGAAACTTCAGGAAAGAGCTGGAGAAAGTTTGCAACCATCTCACCAAGCTGTACCAGAGTGCAGGGCATGCCAGGAGGATGCCTGGGGATCCCTGGTGTGGAGCTCCTCCTCTGGTGGTGCTTCCTCAGGCCCACTATTGAAGAGTTGTTAAGCACCAAGTATAAGGTGTAGCATTGTCCACATTTAAAACTTTGAAGGACCTTAATTTGTAGCAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAACTATTTAAAATTGGCAC + S&'$$$#$$%""#&##%'####$"'%)()('%')&'%'''#'&'($#%&%(##)&&)&*'+',,(#'','+)+,(('$&,-,,.,)-,'(%$%#%*(,,(%#'*-+(,(&&##('&%',+$**($*-+%+*,(+((-,,(%*$%&*()(((%')+##%)*")%**##%+&+(+,-$+))%%(+/0*%+*%%*&*"%-.'2,%+(640/3(/-(/&%"'&,**-452&1,1%,.,,0,.+&24-)),.%0.415+(.(%,.41+2/31.1-,1-3**,)1&*(')+%,*-112/1*)+*2,1)(.*,2'32,/$1)30,,,())-.00-&+**%#'-350,.,-"")3/..0-0+3/51/1,.-),*.0062*#'+)+-),)%+&(*0)+-)3 @rCer/1481/25_1891_CCS ATGGGGCCGCTGCGCGTGGCCGTAGACCTGTGGAGCCGTCGTGAAATGAGCGCGCAGGGACCCGTGGCCTGGTTCCACGCGCAGCGGCGCCAGAACCTGCAGGAGGGCGGCGTGGGGTCCTGCTCTTCTCGCCCGGGCGGTGGCGCTGTGCAGTCCCCAGCCTGGGTAAAGATGGCCCTATGGCTCCCGAAGGGCCTGGTCCCAGCTGTGCTCTGGGGCCTGAGCCTCTTCCTCAGCCTCCCAGACCCCATCTGGCTCCAGCCCTCTCCACCTCCCCAGTCTTCTCCCCGCCTCAGCCCCATCCGTGTCATACCTGCCGGGACTGGTTGACAGCTTCAACAAGGGCCTGGAGAGAACCATCCGGGACAACTTTGGAGGTGGAAACACTGCCTGGAGGAAGAGAAGTTGTCCAATACAAAGCAGTGAGACCCGCTGGTAGAGGTGCTGGAGGTGTGTGCAGCAAGTCGGACTTCGAGTGCCACCGCCTGCTGGAGCTGAGTGAGGAGCTGGTGGAGAGCTGGTGGTTCCACAAGCAGCAGAGGCCCCGGACCTGTTCCAGTGGCTGTGCTCAGATTCCCTGAAGCTCTGCTGCCCCGCAGGCACCTTTGGGCCCTCCTGCCTTCCCTGTCCTGGGGCACAGAGAGGCCCTGTGGTGGCTACGGGCAGTGTGAAGGGGAAGGGACACGAGGGGCAGCGGGCAGTGTGACTGCCAAGCCGGCTACGGGGTGAGGCCTGTGGCCAGTGTGGCCTTGGCTACTTCGAGGCAGAACGCAACGCCAGCCATCTGGTATGTTCGGCTTGTTTTGGCCCCTGTGCCCGATGCTCAGGACCTGAGGAATCAAACTGTTTGCAATGCAAGAAGGGCTGGCCCTGCACCACCTCAGTGTGTAGACATTGATGAGTGTGGCACAGAGGGAGCCAACTGTGGAGCCGACCAATTCTGCGTGAATACTGAGGGCTCCTATGAGTGCCGAGACTGTGCCAAGGCCTGCCTAGGCTGCATGGGGCAGGGCCAGGTCGCTGTAAGAAGTGTAGCCCTGGCTACCAGCAGGTGGGCTCCAAGTGTCTCGACGTGGATGAGTGTGAGACAGAGGTGTGTCCGGGAGAGAATGAGCAGTGTGAAAACACCGAGGGCGGTTATCGCTGCATCTGTGCCGAGGGCTACAAGCAGATGGAAGGCATCTGTGTGAAGGAGCAGATCCAGAGTCGGCGGCTTCTTCTCAGAGATGACAGAGGACGAGTTGGTGGTGCTGCAGCAGATGTTCTTTGGCGTCATCATCTGTGCACTGGCCACGCTGGCTGCTAAGGGCGACTTGGTGTTCACTGCCATTTTCATCGGGCTGTGGCAGCCATGACTGGCTACTGGTTGTCAGAGCGCAGTGACCGTGTGCTGAGGGCTTCATCAAGGGCAGATATCTTGGCCACCACTTGTAGGATCTCCTCCCACCTACGCTGCCCCAGAGCTTGGGCTGCCCTCCTGCTGGACACTCAGGACAGCTTGGTTTATTTTTGAGAGTGGGGTAAGCAACCCTACCTGCCTTACAGAGCAGCCAGGTACCCAGGTCTGGCAGACAAGGCCCTAGGGTAAAAAGTAGCCCTGAAGGTGGATACCATGAGTTCTTCACCTGGCGGGGACTGGCAGGCTTCACAATGTGTGAATTTCAGAAGTTTTTCCTTAATGGTGGCTGCTAGTGAGCTTTGGCCCTGCTCAGGATGAGGGGTCCTCACAGTGGTGGGCCGTCACAGCCCCTCCTGCCAGCTGCATGCCAGCCCCCTCCTGCCAGCTCGTTCTGTGTTCACCACATCCCCACCCCTCATTGCCATTTATTTATTCATCTCAGGAAATAAAGAAAGGTCTTGGAAAGT + K@&IHG1KKIJJHHHCK:DFKKB6BH:HG:4@IJKJJCKKKJGH=:DFF,JJJHII-KCHDH)EIGGF:KHK=EJEKH9KH5GF9G.GIDKF=JC@HC=KHKJ@=KAKKHH:KIAJJJKHCHG/J1FKDGD;H'A;1E90>7@=BA6H=8?@<>=%B?@@07=8%IIFC>G;)H65%5:BCAGFIKHKJ7J@IBE>FJCEHJK;JA5JJCHEA3.4IBJKIJHKKKH0H?HEA3EA8FBDE@>GJKIIJKKCIJE<3)BAGH?K5G@GEIJFF=;IHJ4/KJ3DCKJKE?KIH5JGA7BB?6?8JGC<@;IH?KGGHG5D?F*GA>CDKH2JKGIEKKHCFBFI=9IC;@?=@IBEDK?JBKFKJF5JJE4JGAFJ9A'FGHHA%JI7IC3KJBDIJHB>AHBEIEJDHG'KKHFGJI;:I@9=@:KA>JK3:*H8ID>G9C9BJD>;@DJD.ECGGF=>AG7A=C=/DFH6@E'KJAJ@DCIGBEKJ%HG:I?BJEFCF=@GGI@B;@I@FIGGCFGBJ;J@.KFHJHBGDEGHIGFE7IA>KJ8EFGDCG;FH6DKGBKHJIFAK=J=EJE?@IE>IF@?FAKKKIJB6G;G@B'DE@GDJJJH=GHII>K>#HJA;AE?HIG=5E5?AIGHAHEEJ>98H)G34KGIJIJ@IEDDGCEJJEF:GKH').AKJAEKBJ,JHC;F?>)HJDI@KD=?K=IK2=H6KFGFJI@IF7DHHI;FHH0EEGJ1KHE;IGKH0FKJFFE@KJB8II7H995$B;DDBHC-GG@KCIKBJABDEDI6KIIH0F9G@H9JKKK?2@CDKEH/IJJIB6JE=FKCFDIICBKJIJJD0BEA;B@=-5*CEF<+HHJFI),JJCHA8GDF*HGE4IGFD=:BH0K(IID&JIH0KK:EEJHKCK7JDD0 @rCer/1482/0_1541_CCS TCTCTATCTGAGAGCGTATTCTGGAGCGATATCTCTGTTGACCTTGAGAAACGGCGTGTCTTAAGTATGGTGATGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAGAAATGTAGAGTTTTCTTAGGTTTAAAGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATGATGGAAAGGGTCAATTGGTTCCAGACCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCATGCGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTCAATTGTCGTGGTCAGCGTGGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGAGACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAAGCTGTACTGTATCTATGTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTCAGATCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCGCCCACTTCAGTACCTGGCTCCTTACTCTGGCGTTCCATGGGAGAGTATTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCGTGCTGCGCCGTCCCCTGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATGTTGGAGAGAGCAGCCAAAATGAACGATGCTTTTGGTGGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCGGTGATGTGTCTGCTTACATCCAACGAATGTCATTTCCATCACTGATGACAGATCTTCTTGGAAACAAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTATCGTGTCTCGTGTCGGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTGGTTCTGACCTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTGCTGAAGCAAGGACAGTATTCTCCCATGGCTATTGAAGAACAAGTGGCGTTATCTACGGTGTAAGGGCTATCTGATAAACTGGAGCCCACAAATTACAAAGTTGAAAGCTTCTCCATGTCAGCCACACCAGCCCTGTTGTACTATCAGGGCGATGAAAATCTCAGAAGAATCAATGCAAAGCTGAAAGAGATGAACAAGTCTTGCTGGATGAAGCTTAAACCCTGTGGATCACATCAAATACCATTCAATTTGCCATGTTCTAGTAAATTATTCCATTGTAAAAGGTTACTCTGATACCCTTATGTACAAAATCACATAAAAAATAAAGGTCC + S#''+('$%*%%,(),&"&)*#)-,(&$',))))),-),+(&)&,*#(%)&%#'&(),,(%+&,(*''',$()$$(*$&),..-,-'(+,)%+-,)/*%.+1-//21,)*&+-)0))1-%$&.110$))(($$%&*$,+(+($/*,-+0,'*2,&/)(,%(%+,0,*.%)0/+(-*1/0*/+'00/0*,100&.+*-+&&.,*+1.)4)3)2.-001372'3855-(0($.1&3*1-523769:36954949,622)72:79518,1%%7,8)265,1'30.4-620)1+1'.5/8*-4-62+-*266(2/791851%)0-757-734'/+*4/07/6695..9/1463/,463)734305,.*1..61968:2;&-77'$;/%514,8-3067+/178147/)729&45/7-0:815894*.5&#-4$#$,76.2:84-03624%,$2*)54-6/68/227/3898+&/+07&60,(3+51635*483(65/520,78550409+94+'6576-265562525'6484*24-&)5177+5'-3/3*.0646*4./3&'$,7-5&/3807/999.)423695707*41#33-/2:'66-3:94678$#(.+++.402249622/730,4426'/7540400152./)0+-.(0-73732,6$$0.-((12/.01-645621-0+1.2(2-&0,)03360/)/0,%*+-&$+/.0+49789&*52(8894544)888.-6336/+&)/310+'34,5.5835-4564'0,--59166+21*21&-342%&0210253497$624,&,7411+*329&53.6/2:101$.2))4,.2-3779277)0631'209+3)$#133:933:*33//12:568.33(557684-'(2-34/,+2.-)2-4.+.33&,034693:83674+42(3856-133/8-78&59:3%,4/962*75041616958163545684&5819743(+-+2)2,59&'7,(7*56(43113.67&+3/$.56*8.(*5;82938/,+6*3$302.8,2860/71')'5594/*+76841:0-323:1&2115853.7313(74-:85&764*/'13'6-6%%20:#/)45943623651&894:+54689:.5671-3-&%'618.80(/(-/+19.455'.15/649588836'2-/9:97745(3,*/,5)*7.393&..))38.557547;9:453-$+%)+%+99/2366362992845;:33)/-61#,-$(,)'#)0),-,.'0+*&,,+#(-*&/*&''.()+.,)#$-'"#&&(+-'*,'*$,""!"!!!!"#"""$(&)$$&$+##%+,(%$((%(,&''(+%'('#$$$%*($%),,(,*-,&,',,.+%*'(,((%'%-,)+()#)(,*$*$$+),%,'(+*#%*-,-(&%-)$$)%+''('#)(+(&%'**%%''&(*)%$$#'(-.*&*,-&%),(*--(&%#%%#&#%'%&)'((+&))+&&&+*)-*#-)+)*(((+%$-,'*,+'$!"&(+,&%(+)+'', @rCer/1484/25_1742_CCS ATGGGCCTGGGTCCGCTGCGGCGTGGCCAAAGAGACACCAGACAAGGTAGAGCTGAGTAAAGAAGAAGTAAAACGTCTCATTGCTGAGGCAAAGGAGAAATTGCAAGAAGGTGGTGGTGGCAGTGATGAAGAGGAGATAGGCAGTCCTTCAGAAGATGGCATGCAGAGTGCACGCACCCAGGCACGCCCAAGAGAGCCCTGGAGGATGGTGACCCAGAGGATGACAGGACGCTCGATGAGGATGAGCTGCTGAGTACGACTTAGATAAATATGATGAGGAAGATGACCCAGATGCTGAGACTCTTGGTGAATCTCTCTTGGGTCTTACGGTCTACGGGAGTAATGATCAAGATCCTTACGTTACTCTGAAAGATACAGAACAATATGAACGTGAAGATTTCTTGATTAAGCCCAGTGATAATCTCATAGTTTGTGGCCGAGCTGAACAGGACCAGTGCAATTTAGAGGTGCATGTTTATAATCAAGAAGAAGACTCTTTTTTATGTACACCATGATATACTCTTGTCTGCATATCCTCTGAGTGTGGAATGGCTGAATTTTGATCCTAGCCCAGATGATTCTACCGGAAATTACATTGCTGTAGGAAACATGACCCTGTTATTGAAGTGTGGGACCTTGATATAGTGGACTCTTTAGAGCCAGTCTTCACACTCGGAAGTAAACTTTCAAAAAGAAGAAAAGAAAGGAAAGAAGAGTTCCTCAGCAGAAGGGCATACCGATGCTGTCCTTGACCTTTCATGGAATAAGCTAATCAGAAATGTTTTAGCAAGTGCATCAGCGGACAACACTGTAATTCTGTGGGATATGTCTTGGGGAAACCAGCAGCTAGCCTCGCTGTACACACAGACAAGGTCCAGACGCTGCAGTTTCATCCATTTGAAGCACAGACTCTGATTTCTGGCTCATATGATAAGTCAGTGGCTTTGTATGACTGCCGAAGTCCAGATGAAAGCCATCGAATGTGGCGATTCAGTGGGCAGATAGAGAGAGTGACTTGGAATCACTTTTCACCTTGTCATTTTTTGGCCAGTACAGATGACGGCTTTGTGTATAATTTGGATGCACGTTCAGATAAGCCAATTTTTACACTTAATGCACACAATGATGAAATCTCTGGTCTTGATCTTAGCAGTCAAATCAAGGGCTGTCTCGTGACTGCTTCAGCTGACAAATACGTGAAGATCTGGGACATCTTAGGAGATAGGCCAAGTCTAGTTCATTCTAGGGACATGAAAATGGGAGTTCTCTTCTGTTCTTCATGTTGCCCTGATTTGCCATTTATTTATGCCTTTGGAGGTCAAAAAGAAGGGCTTCGGGTCTGGGATATAAGCACAGTCTCTTCAGTAAATGAAGCATTTGGAAGACGAGAGAGGCTTGTTCTTGGAGTGCAAGAAATTCATCTATTAGTGGCCCTTTTGGCAGCAGGAGCTCAGACACACCCATGGAGTCTTAATGAAGATCATCTAATTTCCTCTTTACCTTAACTGGAAATTTTGAAAAGTTGGCCTAAAAATGTTCCATGTGTGGCAGCAACCATGCAGAGTGACTGAGACACAATTCATTTCTGATTGCCTGACATTCCTTTCTGCAACTGTGGTGGCACCACAAACAGAGCGGTCTTTGTGCTTGCTCTTCAAATGGATGGTTTGTAAGGCTCTTGTTGCATTTCTTAAAAAAGAGTAATAAAAAGGATTTT + 2C0JI9KH.GKFAHEEGJC5HA9B6@;G>KHG@CFIHFIGGHJIH3F@JCHGGJJK*I7@I=;J?.FF9GJDFIK;JCFKEGG;IKK>EE=HFHIK?$IG/?CGCGHIBHBBG*CJCAG>KBHBJIB4IGGE?8=H=HG@CK??9:7BC*EEIFH;HKHKA@HJJJ:EEIHA=>4>FI4>=H@GCBD3GE=HDIJHAKHHAGHG;C2AHK;H8CBI>BBC7EJGGAI@G>EH6JIJ6JGDJD>DDJI9AFKE=IBIEJEFFAGEEBGHK:IJ;EIFFIE@E;8HICFHGJHH@JGJGH?JJCEDII:HEK@?EICIJCEICHHIE=DF.FED?5>9@AJF4GHED8IIHCIGG;C9JKGB@AB)JD@EAJ@;KH4JIGHA2CHH>J=KIDCJK@@B5>>2@59KKGHJJCJFGGIFI;AIHCHI@J7@DB/FG;JJAJCHKG;KHCC>J+>AIA?EIDAD.GH@FEDGGE4HAH9A;K8JA?IJGK:I47A@@DGKHDDDBKKJD9FIKG>F;H<:DFFGHEAF99IHHKD;KKJDFGKD2GIH*FIHEJ>H@JKH>JKKJ?IDIJJIHKHGJAKDA@IJJ0K@*KKKKKJJDJJI:GH5J=I;KJFJIJ3HKIJKJIJJ:AFFGJIGAH@G4H?I7KJB@HCD@CH:H>DCGFKJ>KGKJKKFEI>KKJJIGF@BD??:*EIGIDBHFIIDHDHBFADCEJDKICKIEDCAE@7DGAGDB7HJDJ=)JGDCGA9@B5GJKHGCH;.E@CD;H6E:;?=3/:EEFC98AE?4GD=H@EDID9EF:A@>D=?8A@AFDDF,FFCD6G9>93?E>94B?3F7:;89C7%228><1EIE:A*3B/@?E5;I:F<@=B659@@:>D?DB=;E?E@H@CD:C&=:+>CC8G>:DA;6<18:?EGEFCBCB+HF@A7B:BAC8GA?CEHIBEBH1FG/?=D4FF8>D>@=IFG=C-AF6@AD@2?@GE8GEJ?G?8DEEC=C1F:I9@=;5C;EABDDEA?@EFDCDC>?ECC:5B9FD?)J><:A?2F?.FDAHG?-F2C5GFD=?C;DI:A5.@=0EBCBCDB7B9$.>?=2?=699E8EE53B5>7*<3-.:5<@<.B<7<6E=EE;<7BA9C>>=-8=;6D'?HG>>><<86?50AA??/61.?A? @rCer/1489/1682_66_CCS ATGGGGAGGTCTCTGCGCAGCTAAGCCCGCCTGTCCACGCCGCGCACCGCTCCGAGGGCCAGCGCCACCCGCTCAGCAGCCGGCACCATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTTTGGGAGGTCATCAGTGATGAGCATGGGATCGACCCCACAGGCAGTTACCATGGAGACAGTGACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAATAAATACGTACCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCCGTCAGGTCTGGACCCTTCGGCCAGATCTTCAGGCCAGACAACTTCGTGTTTGGCCAGAGCGGAGCTGGGAATAACTGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGACGTGGTGAGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGGGGTGGCACCGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCCAGACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTGGAGCCCTACAACGCCACCCTCTCTGTCCACCAGCTGGTGGAAAACACAGATGAAACCTACTCCATTGATAACGAGGCCCTGTACGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTGCGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTCCCGCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCCTCACCAGCCGGGGCAGCCAGCAGTACCGCGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATGGCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTACTTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCGGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGCCGAGAGCAACATGAACGACCTGGTGTCTGAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAGGGGAGTTCGAGGAGGAGGAGGGCGAGGACGAGGCTTAAGAACTTCTGAAATCAATTGTGCATCCTTAGTGAACTTCTATTGTCCTCAAGCATGGTCTTTCTACTTGTAAACTATGGTGCTCAGTTTTGCCTCTGTTAGAAAAATTCACACTGTTGATGTAATGATGTGGAACTCCTCTAAAAATTACAGTATTGTCTGTGAAGGTATCTATACTAATAAAAAAGCATGTGT + KKKKKGKKKKKKKKKKKKJKKKKJKKKJKKJKKKKKKKKKKKKKKKKKKKKKIKKKKEKKKKKKKDKKKKKKKKKKKKKKKK9KKKKGGKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKFKKKKDIKKKKKGKKKKKKKJKKKKKJKIKKKKKKKIJKKKIKKKKFHKKKKKKJKKKKKKKKJKKGKIKKKJKKGKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKHKKIKKKKKJJKKKKKKKKKKKKKKKKHKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKIKKKKKKKKKKKKJKKKK?KKKKKKKKKKKKKKKKJKBKKJKKKKKKKIKKKKKKKKKKKKKKKKKJKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKGKHKKKAKKKJKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKK@KKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKK;KKK:K?KKKKKKKKKKKKKKKKKKGKKJIK;KKAKKKKKKKKKIKKKKKKHKKKKKK@KKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKJIKKKKKKKKKKKJKKKKKKKKGKIKKKKKK$KKKKKKKKKKKKKKKFKKKKKJKKKKKKKKKKKKKKKKGKKK>KHKKKKKKKKDKKJKJKHKKKKKKKKK&KJKKKKKKKKKKKKKKKKGKKKKKKKKKKHKKKKKKKKKKKKKKKK9KKKKKKKKKKKKKKKKKKJKKEKKJKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKGKKKJKKKKKKKKKKKK;KKCBKKKKCKKKKKK>KKKKKKKKKKBKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKIKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKJKDKKKKKKKKKKKKKKKKKKKKIKK@KKKKKKKGKKKKKKKKKKIJKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KKKKKJKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFBKKKKKKKKKKKEKKJKKKKCKKKKKKKKJKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKFKKKKK@KKKKKJKKKKKJKKKKKKKKKKKKEKKKKEKKKKKKKKKKKJKKKKKKKKKKKKIKKKAKKKKKKKKKKKKKKJKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKJKKKGKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK?KBKKKKFKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKGKKJKJKKGKKKKKKKIKKKJEKKKKKKKHKKKK>KKKKKIKKKJKKKKJIKKKKKKKKKKIKKKKKKKCKKKKKKKKKKK5KKKKKKKKKIKKKKKKKKKK5KKKKKKKKKKKKIJKKKKKKBKKKKKKHKKKKJKKKKKKKKKJKKKKKKKKKKKKKKKKKJKKGKKFKKKKKKKKKKKK@KKKKKKKKKKKK3FKKKIKKKKKKKKHKKKKKKKKKIKKKKKKKKKKKKKHKKKKKKKIKKKKKKKJJEKKEKKKKKAKKKKKKKKKKIKKKKKKKKKKKKKKKK%KKKKKJJKKHKKK/KKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKJKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKIKKKKKJKKKJKKKKKKKKKKKKKKJKKKKKKKJKKKKKKKKKAKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKJKKKJKKKKKKKKKKKKKKKKKKKKHIKJKKKKKKKKKKKKKKIKKJKKKKKKJKKKKKKKKKKDKKIKKKKKKHKKKKKKKKKKKKKKKKIKIKKKKKKKKKKKHKJKKFKKKKKKKKKKGKKKFKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKHKKKKKKKKKKK-CB#")5<;:<>496;>>?A9(:<88A=8AAB;B?A?9?=7<<<=BCA6?>==7A;5>>.<:68=>;=B;?=FAD@<=B@?BFEEGADCBE3C>=CF:8>@C:BBAACBED?EAEBE;<D;?B@?<@=E4B/@<@=<==AE6@@@A9BCAD?0C<@::B=@B9@?49);37026,<>:*?C/674@D?;7@<=2<:2>3<:A;>?:<;9DF6?>@D;=4?@@??>:76;6<;-@=?<;?=<&8,==:@ACF.7@>A2%?::G5>=54A??E<;96@.;?C?>B?4ABDCAEE@?GF>@BFGEGF@AGDFGB1CF89<<(:DC=AA>8B=F@C5A=8C2=<7A4@G:4>BA=?B<62@BDA=B?3@DF=<@FF=%5?BE=/@*@@>AAB>3==AFCAC=@:C9?>>7A>>==?B@?-6>4A@?ACBA;?9BBA>?<3D?CEA<9DBBF>CB@FGF?/9DC;<@9:%:826@@AA*;8C@@E=@=D?AA;DEEDBB@=4@:=CDC@7BC;8;@EEG?ADBAA?<,D@;;3<7>9:$25,920&<7224>72,4263545677===:A@C7@>8>>;25@=CAD0GFGE5DCEA?BEFBDCF>C>;>C<2<9EA@;;:@AA>A;FEFGE7;=A><=:4BCC78AF?>A=>F2+9=7=:B@E5ED>D>7A;@B@?@/@9%2876646:=205647<823.5827;::83:4=4:9.103(-1,3/0013(527743.,&1%07355-7388>58;?=:902266727.73<7<9A:+??;A;6<8=<:=25-'54):BC?A?/:>)4<=B4;=;A=;9<7>A5:6<<9@AB@;9<>;8?B7>-759:5A@:@3>:85:;8B=:78<:4?8<@?B>@>.:@?1.20<;=;A>AB=7>=5@;B7>38;5?6:<8-=3717><:9=97:;?=?=;87;/:8%9<:@BC<>0/??C6:CA::=6?>;B=?:??5CA8C??838==?;>;59BC??;:;7>(;9;>;:5684084;,/7=29595-:0447@27?>;?===8=.6;;;886<@C@3?60:<=/>;:2;5=B<64>>::?>:=AB?ABCA=:AB/B@98A7>CC;@?A789>&<9=:,<@6:6;75758<90:;A=+@AB?B>@)?>>BB@03'178;3@>@?<&<90>;:ABA-8>9>A@B<9:;=8)A:@15A;79:69:0/;<>9@8A;9*9986@>;:46:.:>8?=?/:9(72377991;>?@5.:689=:9:C=??>@AAB4;8><5=7.=8=<;<47?C?>5(?20788/=?@@3BA'89=@?@C?=AA2=3@B8==???;9;:;>@=(@?=B=D??BA3?<7AA7A4ED?@EDF<@A;?5@><.B::8'775*<>>>846>A@9A@>?<@D>FBEA&?=;99>0<:<8(=>>?,;A@D/BCBE@A7D0E?CA?DA&EAE?F0F@?=E@$B9=,A>#@F:FA9BB3CAE>AB+AAA;42AF?AC<*E?B>@BB)978<==:9BG@BEE8E@7B=D>B;AF=>BB=@DEEEA;EE6;9;EEA;@>B@B @rCer/1497/25_2445_CCS ATGGAGCGCGGCCATGGCGGGGCCCTGAGTGCCAGAGTGGTGGTGTTGCTTATCTTCTGGAACCCATGCAGCCAGATCCCAAGCCTAGCAGGGCTGGGGCCTGCAGCCGATTCTGCCCTGCGGTCACAGTGCCCTGAGGGGTCAGGGACGCTGTATGTATGCTCCACTGAGTGCAAGGCGGAGGTGACGCCTCCAGCATGGCAACCGCACCTCAGCTATACCTGGAGGATCATACCAAACAGGCGTTCGGCATCATGAACGAGTTGCGGCTCAGCCAGCAGCTGTGTGACGTCACACTGCAGTCAAGTACCAGGACGCGCCTGCCGCCAGTTCATGGCCCACAAGGTGTGCTAGCCTCATCCAGCCCGTCTCAAGGCCATGTTCACCAATGGGCTGCGGGAGCAGGGCATGGAGGTGGTGTCCATGAGGGTATCCACCCAAGGTCATGGAACGCCTCATCGAATTTCGCCTACACGGCCTCCATCTCCATGGGCGAGAAGTGTGTCCTTCACGTCATGAACGGCGCTGTCATTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTCCTAGTGCAGCAGCTGGACCCAGCAATGCCATCGGCATCGCCAACTTCGCCGAGCAGATTGGCTGTGTGGAGTTGCACCAGCGTGCCCGGAGTATATCTTACATGCATTTCGGGGAGGTGGCCAAGCAAGAGGAGTTCTTCAACCTATCCCACTGCCAACTGGTGACCTCATCAGCCGTGACGACTTGAACGTGCGCTGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGACGGTTCTATGTCCAGCGCTGCTGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTTCTGCAGATGCAGCTGCAGAAGTGTGAATCTGCAGTCCGACTCCCTGCAAGGACTACCTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGGGCGCCCAAGTGGGCGCCTGATCTACACGCGGCGCGGCTACTTCCGACAGTCGCTCAGCTACCTGGAGGCTACAACCCCAGTGACGGCACCTGCTCCGGTTGGCGACCTGCAGGTGCCACGGAGCGGCCTGGCTGGCTGCGTGGTGGGCGGGCTGTTGTACGCTGTGGGCGGCAGGAACAACTCCCCGACGGAAACACCGACTCCAGCGCCCTGGACTGTTACAATCCTATGACCAATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCGCGCAAACCGCATCGGGTGGGGTCATCGATGGGCACATCTATGCAGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTGGAGAGGTATGAGCCAGAGCGGGATGATGCACTTGGTGGCCCCAATGCTGACACGAAGGATCGGGTGGGCGTGGCCGTCCTCAATCGTCTGCTTTATGCCGTGGGGGGCTTTGACGGACAAACCGCCTTAATTCAGCTGAGCGTTACTACCCAGAGAGGAACGAGTGGCGAATGATCACAGCAATGAACACCATCCGAAGCGGGGCAGGCGTCTGTGTCCTGCACAACTGCATCTATGCTGCCGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGTTATGACGTGGAAACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACTGTCCACCAGGGGAGAATCTACGTCCTTGGAGGCTATGATGGTCACACGTTCCTGGACAGTGTGGAGTGTTACGACCCAGATACAGACACCTGGAGCGAGGTGACCGAATGACATCGGCCGGAGCGGAGTGGGCGTGGCTGTCACCATGGAGCCTGCCGGAAGCAGATCGACCAGCAGAACTGTACCTGTTGAGGCACTTTTGTTTCTTGGGCGAAAATACAGTCCAATGGGGAGTATCATTGTTTTTGTACAAAAACCAGGATTAAAAGAAAAAAGACAGCACTGCAAATAACCCATCTTCCGGGAAGGGAGGCCGCGATGCCTCAGTGTTAAAATGACATCTCAAAAAAGAAGTCCAAAGCGGGAATCATGTGCCTCTCAGCGGAGCCCCAGGAGTGTCCAAGACAGCCTGGCTGGGAAAGGGGTGTGGAAAGAGCAGGCTTCCAGGAGAGAGGCCCCCAAACCCTCTGGCCCTGGGTCCCACCCACCCAGCCAGCCACGCCGGCAGCCCTCACCTTGTGATTTGTTCTTGATACCTGGGAGGGGGCCAATGGGGCCTCAGGCGGAGGCCCCCTCTGGAAATGTGGTTCCAGGGATGGGCCTGTACATAGAAGCACCGGATGGCACTTCCCCACGATGGACAGTTATTTTGTTGATAAGTAACCCTGTAATTTTCCAAGGAAAATAAAGAACAGACTAACTAGTGTCTT + -,$+),-)(%%&++),.-%,,%$,,++-+$(,.--+#%'&(%),*,--,&,,-,&*',+.))$%&(++-'($)'")*'**,.-+.--),*(,--+%,,+,,(,-,((---)(#*+'*++,-*+,&'+'+-*,..---$+**-,'&++)-,-)))$*+,),+%+(*+(---,-++),+.,+.-,**+*')$,)$++----,.+#-&)*)-*(#),+-((,)#)*)+,-.-,,)++(),*.-(+,(,-,+(+,),-,+'-.+*-,'.,+)-&),(,)-*+--),-,&+)*++--&(-+,(,+,(+,+-',,,-,)---+(++.)+)*)$+)-+,''+,.*-,+&$',-+##)-*)+,.---,'%,)%'%%$)&%&+(-,.-+)).)),,',,%+,(+--&*)-+'(')'++,-.+(+,(',()((%#)+(,-,)+)()#**&+)++---+.,,,)(')+---+*,$,,,((+*--,'(,*-)',+--*,-+-,.-))---,,,*'&*),-.----)'%+-(,,+*+')-+(*('#')-,,&--+,,&-)*$+*(&-%(((//(/'*/+,+#&+,-&%(%%&$)*+,,.)',/.-('0(/011/1-1*$/,-+.%0+*01.-211--/1102-/011111,/.1/0-,-00-/01).'01&,-)$'*,)(%'(+0-/+-(0/-&,/01.1/(1-10,/,-0-.,1/0121,20&,$()-0,..+,,/*.*.&&%*)+(#)%*'**+.&($%+*-110'-'+(1*,-1/111,01-1%///+0).0,-2-1,%+-00.,-,,-,&,+-0'-*%,..++.*,)$*%(--,//&,-2011,,,,2-&,-+*-.-0/'*,,.+,+--.+++-0&$'))-,./,*+,-*++*,,.,-)*/,01'01'-./-+-*-+*-*$%$*.0.-.+0-1+,'-&&0.+.%(,%%%*+*-0'//2./0.12/11*-00,0.--1.0111/-00...(+-/+'(-,1-.*,+*)$)&****%***.$**-,*))**(*1./100,))%,$,(,-*,--+2*100(/./--'),++*0,),/,.*$)(%-+).'-),-1.,)0&&&)/.)#*('*+*./'((%*-21100*+())--1*/-//&/*1-12-112/*..-/$**&/.-+0./10+.*,+,1+)+/./,))..+*.+-/((+0,1-.-.//.(20*-&.,.1,.2.-,/).-10/-,'+%+01+**)/*(,/10.,+),.)-)-.1102210/1'1-*.0111110$-*'/,00(1112011-0%0.'$-.-'*++,*)/$**+,.),'+/,.,,111100'.0)%,011)111,0/0'+,*.-/-1-/*&*.(../002/-/)'+/./-4.,-5//*.*#('.%'+,-.).*14303*23365202,.45611-*222/4641402'232-2310/0032)203.44155)1-/%0/.024.53454)3-2%02,4,.25601+520/3253122263601.23-),-*%..543452&2135611251564/4,546424516242650335*4103,16646460,1/021131026/512265513313346%32235452-01031/1*40.311-3213265642-43441,0441266616*553*/442252+55522552226/22443424632-/4)1/5454354622206142/.5504'/1011,-043,)255032..12.,-/0++/0/4204)2)/2&322/5021/31250.10464666663/2,0242/23524252),0124442431655.#+123034/644%514)-45/%/002)21./1+222044501,.+10/*10-36.4)10443425//034-04,,44,0/1)2150640.1+/0*/440+.1335-5000%0/0,.455-.3162/566440.3301.0)02215/5513360361(//&2,6412+3/1/210136145,14044616564+/01+/4+6624,112,634-0.411-6422665-52643650456644%22/22536660216661%-/,53652.1*.3/244665)3.44566456624/244540',50.5435-.(.2-21&34.-/.(+1634./4546515452/+.0/00,4$0/1-+01)21*./560.32*)04)51%-2/1-./4/-64223523+1*+/01-/.002260*/041/25+'2,('$0/3)224624+525234161%306,456004134.+5+45320/.(/$-,//0.1/1$1,(041.10614--/1.04*102'$,-2/4/5+2.*-/+(33-,&#-0+/2335363&1000+44./.13&1504014403-342*3.0'+.6261-10013226344(4/-3/'.22-- @rCer/1498/2818_53_CCS ATGGGAGAGCCAGGGTAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACAGCTGCGGCCAAGGAGCCCACCAAGCTGGCCGACGTCTACCAGGCTGAGCTGCGAGAGCTGCGACTGCGGCTCGATAACTCACGCCAACAGTGCCCGGCTGGAGGTCGAGAGGGACAATCTGGCAACAGGACCTGGCACCGTGAGGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCGAGAACAACCTGGCTGCCTATAGACAGGAGCAGATGAAGCCACCCTGGCCGTCTGGATCTGGAGAGGAAGATTGAGTCACTGGAGGAGGAGATCCGGTTCTTGAGGAAGATCCACGAGGAGGAGGTTCGGGAACTCCAGGAGCAGCTGGCCCGACAGCAGGTCCATGTGGAGCTGGACGTGGCCAAGCCAGACCTCACCGCAGCCTAAAGAGATCCGAACGCAGTATGAGGCAATGGCGTCCAGCAACATGCATGAAGCTGAGAGTGGTACGTTCAAGTTTGCAGACCTGACAGACGCTGCTGCCCGCAACGCGGAGCTGCTCCGCCAGGCCAAGCACGAGGCCAACGACTACCGGCGCCAGTTGCAAGTCCTTGACTGCGACCTGGAGTCTCTGCGAGGCACGAACGAGTCCTGGAGAGGCAGATGCGCGAGCAGGAGGAGCGCCACGCGCGGGAGGCGGCCAGTTACCAAGAGGCGCTGGCGCGGCTGAGAAGAGGGGCAGAGCCTCAAGGACGAGATGGCCCGCCACTTGCAGGAGTACCAGGAGCTGCTCAACGTCAAGCTGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGCGAGGAGAACCGGATCACCATTCCTGTGCAGACCTTCTCCAACCTGCAGATCCGAGAAACCAGCCTGGACACCAAGTCTGTGTCAGAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGATGGAGAGGTCATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGAGGCAGGACCCACCTGGTGGCCTCTGCCCATCTCATGAGGAGCCGAGCAGAAGCAGGATAGTTGCTCCGCTCTGCTGGTGCATTTCCCCACACCTGAGCTCCCGCCACCCAGCTGCTCCCTCCCTCCTCTATCCCTAGCCACTTGCTGCCCTAGGCTCGTCAGTATTAGGCCTGCCAGACGGCACCCACCCAGCACCCAGAAACTCCAACTAACAAGAAACTCACCCCAAGGGGCAGTCTGGAGGGCATAGCCAGCAGCTTGGGTTAGAATGAGGAGAAGGAGAGAAGGAGGAGGGTGGGGGGGGACCTACTACATCGCCCTCCACATCCTGATACCTTTGTTATGGAAACTGTTGCCAGAGCTGGAGTTCTCTCAGGGTATCTGGAACTGTGCCTTTGAGTTTCCTCAGGCTGCTGGAGGAAAACTGAGACTCAGACAGGAAAGGGAAGGCCCACAGACAAGGTATCTTGGCCAGAGGCTTGTTTTGTTTTTTGGTTTTTATGAGGCGAGGTCTCCTATGCTGCCCAGGCTGACCTTGAACTCCTGGGCTCAAGCAGTCTTCCCACCTCAGCCTCCTGTGTAGCTGGATTACAGGCTCGAGTCACCATGCCCAGCTCAGAGGTTGCTCTTCTAGACTGACCCTGATCAGTCTAAGATGGGTGGGGATGTCCTGCCACATGGGGCAGTCACCTGCCCAGATCCAGAGGACCTCCTGAGTGATGACTCAAGTGTCTCAGTCCACCTGAGCTGCCATCCAGGGACCCTGTCTGTGGGCGTGCTGTGGGCAGTGGGAGCTTGATTCTCAGCACTTGGGGGATCTGTCGTGTACGTGGAGAGGGATGGGGTGCTGGGAGGGATACAGGGGGCTGCCTGGTCCCCAGTGGTGGTACAGAGAGGTCAAGCCCAGGAGGACTGCCCCGTGCAGACTGGAAGGATGTGGTAGAGATGGTGGAGAGCAATTGGGATGCGCTAGGCATCCAAGTAGGGGTTGTGGGTGACCAGTTGACTTGCCTCTGGTTGTGGAATTAAGGAAGTGACTTATCCTCTTGAAGATGCTGAAAAAAGGAGAGAAAGGGATGTATCCATGGGGGCAGGGCATGACTTTGTTCCAGTTCTAAAGGCCTCTTCCTTGCTGTGTCATCCCAGGCCATCCCAGCCTCTGAGCCCTGGACTGCTGCTTCTTGACCCAGTAAGCCACTGCACACGTCTGACCCTCTCCACCCATAGTGAGCGGCTGCTTTTTCCCTAAGCCAAGGGCCTCTTGCGGTCCCTTCTTACTCACACACAAAATGTACCCAGTATTTTAGTAGTGCATATTTTACAATTTGTAAAACAAGCACGAGCAAAATGAAGACACTGGCTCATATTCTGCAGCCTGGAGGCGGGTGCTCAGGGCTGACATGTCCACCCAGTGCACCCACTCTGCTTTTTAACTGGCAGACTGGTAAGCAGACTGGTGGGATCTGTGCCCAGAAATGGAACTGGGAGGCCCACTTCAGGGTTCTCCTCTCCCTCTAAGCTGAAGAAGGTCCTTCCCCTCCCAAGACTTGGTGTCTTTCCCTCCACTCCTTCTGCACCTGCTGCTGCTGCTGCTGCTAATCTTCAGGCACTGCTGCTGCTTTAGTCGCTGAGGAAAAATAAAGACACATGCTGCGCCCTTCC + .,02,,10/.&..-,'$'&/1011010--11110,0111*--%(+/,.,,+$/1..--00/,,.&1..*0*,,,,0,/&/*0.1-*-$%&.,+--1-+11,-(*2+1-)0)00+)*+*,--*/(-+)&../.**.%0,/,*+,(*.&/212001.2-)%*%,(''(,2.0*%+11.,11/11./1001-.0-.0,02+,.11-$((.)--&-,+1,1.1011.+,%-*))0(&-*1./..0,,,1-1-/.'/.&+*.**/-.1&,-/+-//--,-010)+)1.110'100..'1)1*..+00-%.*2-0*)&*--0'',&-+1/&00-+%-1-1-1.-(##%',0-.,-&+-%',0*(0*,&/0-000/11-.+*-,1/0***0..//,-.(.-'/-&,..111,.%/+2/12.0.201,.(01*.-(+/&-.%+0..),,*$*&0,0/11,000**101,22+.1.10,-2.10&01,,210/-121-1.11,1+0*.*#0--20+-/(++.1.0'.0.&0)$/)-,%$&,,,...1.-*1,0/.1/&,**.'/.-2-'01/1,102,/-,1/&*(*)$0/,,2.&+,,22/..11,1-.%%-++*'01..0*,(x/)*+&10.111-,'./)..*.%-*111/,*-,.,)+*.+,,-.,.,+//-0/2+)+##-,+'1+)#%//-/+0*+,+,(%+1..,11101011,2-11-,,+$-,,0-02,,,($%-011..1/*,&00&0/.1/%',-0-111+01-)/)0,+&,*-1+.*+++&/1101+&1,.,,($'$.&'+))-%0-1.+0'1-.%1,.-.,.01/.1945:/65:2:425,+(802//:5+/9:8:66:0-0.99.367-1.)4;577:::777:995624-.54796275974:859/66%-77439339705-38017169.:1488.06/850;739;893/(99299668./5.50*0+/,1-10-1,30'2(34-38515:93;84%723933878985/819653012..43014114.2'51522/2$/22/+320+-0/143.3,2/140645541'2254(2140433205330,33'5/2+166166166323*4+'/.-,1$4+*0,553461/-3$3555,*3))566544435&)/10/*%35512431-51111,445*2*/2.2525633/,54.434,3314/3/66(105+52,,5421/2)43'%&"/4,/55023*0*4-/-$,0//*015541+5/.04(/.'3620034&543'315565/11662124+60506/21'-10/.130334)3-/10&)53%/11,*02%150*01)0434314).-%4&1.61140/.,$**1*.%.,-(.$,/)'*.'#12-),'-%4401'(/42,40034(41/331,43/-)*+,/%2/)61524155,5124/00*52420542.$/'242.0*,-)254///$0%041221.46+*.455.62440601126540563355)/4+.,*4500151162650/2(2.2+40#/325514,1/20/06(344'35,.214+'031,,./323#,25555+00453&34+.+,3160+1201-053-5346504511/122.46454/%)(061520'3/5,5614/)-/224.4342/*$10...0(-5/2652(5652-44*110162.,%*354344.1$3-.///50241/0.115621534/0,5/124111-,4/5666/,0132+1,(&/-..*,+$++,,'&,,4/05*3)12/$'++*#'*&-0)///+++000/0/565010545)/214)52555/*)//5//424546,320&)45500.-*(/*,1502/12&0.*120-2155-+22023/-*.3*236646+1+0,122103+1/*2//-.,0/'-0)&,#1.3022&/3.'(/,1*1054*3(.2510+3034*2/0.+-.$34-+/-+,130540-02*./(1414515042/52.11.,141.3/.(0/$,/*+-///+)$$)*&'%(%.30/-./%.+#+0./03(+0-2.5/).42/,%1-.,.-'+.*/,-261'-,1,%'*.2,-#&$&*2&1/-'3*,&,'#,$.3312,+(0162,334.51505322-.%2))*+22.'.,#,--,2+*,2*1152+24-.)34-0'3.1)//-.+-+3(/441'.,5.405+4,1).122502101.*(,-(*).)+-&(/0-,0*.+%.*&()%),*'*,-)))0431/54'/124,26/22-+$0--332.,0430-.*//()30'-0'-/10,.**(,,.**-.%,,'-/$%.%.*06*2+-.((,/(),,0)4.20/..-0522/-2053%-12311(34.)265/2)'.-3,$./+330%+05.00((.030)2/0-+0-34.+,11'241.212/+25*4.//5/--&%30,-*0/.00/$%$+$0/*0))23.-52./*14*31-33$30-..30.(10402--,/33)4-//+()')()*((*62,,'-./)(*0/6/1+3123/2,&,..4('2$$%3.46.32$,-,022(-20**23220*3110+&45/./$-133+$3-+#+0*60441'*22**$&'-4+2.30,$+2)+0&..&245).61))+#)5+3152/3//-+%011,0.0251-/3-541'3+*1/050/14&$,%0/1)*0*&$#'6666350)&(/.-4+0/1353.1/'2*-, @rCer/1500/1853_58_CCS ATGGGGAGGTGTGGGGAGCCGGAGCGCATAGACCTTGCAGACCTCGCCGGCTTCACACTCACCTCGGTGTCTGCTGCACCCGCCGCTTCTTCTCCTAGGCCACGAGACCCAGCGGCTAGAAATTCACCATGTCTATTCTCAAGGTCCATGCCAGGGAAATCTTTGACTCTCGTGGGAATCCCACTGTTGAGGTTGATCTCTTCACCTCAAAAGGTCTCTTCAGAGCTGCTGTGCCCAGTGGTGCTTCAACTGGTATCTATGAGGCCCTAGAACTCCGGGACAATGATAAGACTCGCTATATGGGGAAGGGTGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGCGCCTGCCCTGGTTAGCAAGAAACTGAACGTCACAGAACAAGAGAAGATTGACAAACTGATGATCGAGATGGACGGAACAGAAAATAAATCTAAGTTTGGTGCGAACGCCATTCTGGGGGTGTCCCTCGCCGTCTGCAAAGCTGGTGCTGTTGAGAAGGGGGTCCCCCTGTACCGCCACATCGCTGACTTGGCTGGCAACTCTGAAGTCATCCTGCCAGTCCCGGCTTTCAATGTCATCAATGGCGGTTCTCATGCCGGCAACAAGCTGGCCATGCAGGAGTTCATGATCCTCCCAGTCGGTGCAGCAAACTTCAGGGAAGCCATGCGCATTGGAGCGGAGGTTTACCACAACCTGAAGAATGTCATCAAGGAGAAATACGGGAAAGATGCCACCAATGTGGGGGATGAAGGCGGGTTTGCTCCCAATATCCTGGAGAATAAAGAAGGCCTGGAGCTGCTGAAGACTGCCATTGGGAAAGCTGGCTACACTGATAAGGTGGTCATTGGCATGGACGTAGCAGCCTCCGAGTTCTTCAGGTCTGGGAAGTATGACCTGGACTTCAAGTCTCCCGATGACCCCAGCAGGTACATCTCACCTGATCAGCTGGCTGACCTGTACAAGTCCTTCATCAAGGACTACCCAGTGGTGTCTATCGAAGATCCCTTTGACCAGGATGACTGGGGAGCTTGGCAGAAGTTCACGGCCAGTGCAGGAATCCAGGTAGTCGGGGATGATCTCAACAGTGACCAACCCAAAAGAGGATTGCCAAGGCCGTGAACGAGAAGTCCTGCAACTGCCTCCTGCTCAAAGTCAACCAGATTGGCTCCGTGACCGAGTCGCTTCAGGCGTGCAAGTTGGCCCAGGCCAATGGTTGGGGCGTCATGGTGTCTCATCGTTCTGGGGAGACTGAAGATACCTTCATTGCTGACCTGGTTGTGGGGCTGTGCACTGGGCAGATCAAGACTGGTGCCCCTTGCCGATCTGAGCGCTTGGCCAAGTACAACCAGCTCCTCAGAATTGAAGAGGAGCTGGGCAGCAAGGCTAAGTTTGCCGGCAGGAACTTCAGAAACCCCCTGGCCAAGTAAGCTGTGGGCAGGCAAGCCCTTCGGTCACCTGTTGGCTAAATAGACCCCTCCCCTTGTGTCAGCTCGGGCAGCTTGAGGCCCCGACCAACGCTTGCAGGGGTCCCTGCTAGTTAGCGCCCCTCACCCGCCGCCGTGGAGTCCGTGCCGCTTCCTTAGAACTTCTACAGAACCGAGCTCCCCGGAGCCCTGTTTGGCAGCTCTAGCTTTGCCGTCGTGTAATTGGCCCAAATCACTGTTTTTCTCGCCTTACTTTCCACCAAGTGTCTGGAGTCATGTGAGCCTCGTGTCATCTCCGGGGTGGCCACAGGCAAGATGCCTGGTGGTTTTGTGCTTAAAATAAAAAGCCTTCAGTGACCCATG + 7@EA<4A=5CB<>@A63=<93,9=<=A6;DAAB?D8@D@@3@@AF@9::6;EC@:<:AB>C;ED6=9,>9=ADBC?99?C77F=AAB;DD?B8F334B;E=7C@@A;CE;3BE1B7B:@@@DADC6?;=?B*9E53A0B?C>A2DDAE8C>C@CF?D>@>A'D=ADFBF=BDC6?B1C4=FB>EA4@?CA;%9=AA=A:@1A7>>;A@BEFA?9DE<@AEFDDDE@B9%6CAA8A:>E:@?CC>B:7:=967;<.?;@0&650?7=?A9G=CDEA786?8@EEE@>2?7DG7D=@B+DF>D>8;8<%9B2?.AD/;9)A?9D:77*@;F9AEA=>+;A>?FEB>DB=66@C:=CF?B:@BAA?>'9BGA;A:@;:<<5?:5/@<=3:=@9/;4;/.650$64/AB>=45>?GA3>DA>B,=;?@=@EB?-@>>@B(?CB;;9B<;797=<=>>=>?D9:=?39*AB8?8>>;;5@>F>D>.:=+EB<@B.DB:>:EDEB8=,@BBB@A?3>=689>?6797B/;C2C?C:?;?BB8@>9=9387:?C6B=/@@8;5@97E3?=21?:@E8D<<198;<=50:9?=267.<:?)A<98A7>E@C?>AEA=FBE@;ECD;:?:0BC=A/9=51=?A(0BAA6EC;?92@C4>=8?@4?.=?>5056;A@C6:DC4AE<6:>71ED=@C?CD*AD68EC:@;A@4879?2*7977:DEED?>E=>@FAB@D4>@B>DC>EGCC>9:BA?3C=69;EDE7DDADCAD@B5CD:=BAGE:A=A>D;?EB<8;;AE=G>,=?9E@@=A3C>C83)*>><9:77=;DB4BF3A9?<=43>A/EBDED>2BCDE=EBDD8B=E>EE>EFCABC=6?=:9A7;;:6<@;'=5?CA?CA@<<=2?85#>7?;9<.EEDD:A:A1<8=C;>2=@C4??F?CCDF59>?GCBA@8DD=@??-D@EC=@=:A8C@1>=B9C7B?EC9@A=E@8<6?17>7B0@BD1:B=80@>;@;<<.<9&8@=CCF@?A?=7BC7.50.156665947<<61446==8:21;;/;8;79:<.::(76/,(/9=:6>38986/757-75;967'=?;;:;88:1:<<4>;?876:3:*/8<<3-28:35,,3;-57279:=89>:7>;=/;77;<:=88:61<5:8710:7+16=6;:=/7:8021:)=<;4721.=;7=;07;588??<;897=<5387=3<876<858=999;438>9=6;=74(2,/073+75;7::6334699882325:;8;9(353,40.889.,531/5.03472-41607298/69593666/8:730/.+716/,1/9./2%89/,:8372.978961405673867133651)2:3/%13208488/757 @rCer/1504/25_1873_CCS ATGGGGAGAGCCCTCCCCAACAGAGCTGAGGCCAAGGCCGACTCCCCTCTCAAATGGGGTGGTCTGGGCCTATGACAGCCCCTGCAGTGGAGTCTGTACTGGCTGCGGGGGACCCTGCTCATTTTGAAAATCTGACATCAGCTGGGCAGTCGCCCCCCTCCTTCCTTCCTCCTCTACCCTGACACAGCACTTAGCACCTGAATCTTCGTTTCTCTCCCAGGGACCCTCCATTTTTCCATATCCAGGAAAATGTGATGCGCCACAGGTATCAGCGTCTGGATTGCCACTTTCACATCTTAGCCACAAGTGACTCAGTGGAAGATCCAGAGGCAGCAGAGGCTCGTCAGGAAGATGTCTACAGAAAAGGTAGACCAAAAGGAGGAAGCTGGGGAAAAAGAGGTGTGCGGAGACCAGATCAAAGGACCGGACAAAGAGGAGGAACCACCACCTCCTGCATCCCATGGCCAGGGGTGGCGTCCAGGTGGCAAAAGCAGCTAGGAACGCAAGGCCTGAACCTGGGGCCAGACACCCTGCTCTCCCGGCCATGGTCAACGATCCTCCAGTACCTGCCTTACTGTGGGCCCAGGAAGTGGGCCAAGTCTTGGCAGGCCGTGCCCGCAGGCTGCTGCTGCAGTTCGGGGTGCTCTTCTGCACCGTCCTCCTCTTTGCTCTGGGTGTCTGTCTTCCTCTATGGCTCCTTCTACTATTCCTACATGCCGACGGTCAGCCACCTCAGCCCCGTGCATTTTCTACTACAGGACCGACTGTGATTCCTCCACCACCTCACTCTGCTCCTTCCCTGTTGCCAATGTCTCACTGACTAAGGGTGGAACGTGATCGGGTGCTGATGTATGGACAGCCGTATCGTGTTACCTTAGAGCTTGAGCTGCCGGAGTCCCCTGTGAATCAAGATATTGGGCATGTTCTTGGTCACCATTTCCTGCTACACCAGAGGTGGCCGAATCATCTCCACTTCTTCGCGTTCGGTGATGCTGCATTACCGCTCAGACCTGCTCCAGATGCTGGACACACTGGTCTTCTCTAGCCTCCTGCTGTTTGGCTTTGCAGAGCAGAAGCAGCTGCTGGAGGTGGAACTCTACGCAGACTATAGAGAGAACTCGTATGTGCCAACCACTGGAGCGATCATTGAGATCCACAGCAAGCGCATCCAGCTGTACGGAGCCTACCTCCGCATCCACGCGCACTTCACTGGCTCAGATACCTGCTGTACAACTTCCCGATGACCTGTGCCTTCATAGGTGTCGCCAGCAACTTCACCTTCCTCAGCGTCATCGTGCTCTTCAGCTACATGCAGTGGGTGTGGGGGGGCATCTGGCCCCGACACCGCTTCTCTTTGCAGGTTAACATCCGAAAAAGAGACAATTCCCGGAAGGAAGTCCAACGAAGGATCTCTGCTCATCAGCCAGGGCCTGAAGGCCAGGAGGAGTCAACTCCACAATCAGATGTTAGAGAGGATGGTGAGAGCCCTGAAGATCCCTCGGGGACAGAGGGTCAGCTGTCTGAGGAGGAGAAACCAGATCAGCAGCCCCTGAGCGGAGAAGAGGAGCTAGAGCCTGAGGCCAGTGATGGTTCAGGCTCCTGGGAAGATGCAGCTCTGCTGACGGAGGCCAACCTGCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTCCTGCTTCTGCCCCTGTCCCAGAAACTTTGGGCAGCTCCGAACCCGCTGAGGGTGCTCTCCGACAGCGCCCCACCTGCTCTAGTTCCTGAAGGGGCAGACTCCTCACATTCCAGCACTTTCCCACCTGACCCCTCTCCCCTCGTTTTTCCTTCAAATAAACTATTTTGTGTCAGCT + -,%2133+22*351)134.130111104335363401,1/31*$35321'-)/10(301203./0-10,50/.43312.324'21-14022-13-1044,352335%30224-+/0/0*02%,,/3+41514/....1-%.+3266.23245+6662551244/625-0/%0.0/(%0+1133.0.50530,2/3442240300(235-54*130.34/(432)0-/*10'1/,,0.,.11,1.)/'020)*')+,/)).0-/-,,('--/-0*),-*/.+00-0-+%**+*01.1..*-10/0/2,0/1..0/0/',(-...+2%-,+1-,0/%*',1-,*0/1+)+*2/*+01/,.1/+)(//+/,/.')/'/)'020-2/0)..&-,-%.-,./..0//0/(+1,11+'../+,'1.*,/)2/0..%*+/./2+,.-/.20*0((*),/-.-*%&01-*)0/2/(0.1/.2,.+.21-/1,..%*.,-0+-/1.//'0,-*0+.1*1+,-/,/.-20-*/..(-*)-,///*..,+1++-/,/.-/,-1-0*..,+/0+/*&'+-/,-'+'++.-'.,(.1100(1/--..%)(/+0)+102.1+1-2-,(-1,-+0.00-110010..00*00,0+/(.-,+00.*.**(21/*-+'*&*$).0//-/&+***-/-+&'.000,..-0-/*/+0./1.'0.+*--0.0,/--(--+/--0100.10&+./)-'.+..,0/*$*+)*-/.*.+.$)*).%)/-.*+-+/,0//1+0+/(--/+-)--1$)*/.2.221./0-,/(.,./-'*,)00-0''0*/(.-.$',11.),.,00,1,,+0-)-*%,01,0.-.1+-..--+,10--$.-1010.01*&-.,/.,2...+000/00-,2-*)00/*#%)&-0///,*0/.2/2/*/**/,//,0010-**$+/'0.,21-0,--+////-*'-20.&*,'//01100.)0+/-/,*...-,0+,/,(/,00/////1/10.,11.33130,-,/..-125.4,030/*0612314220*33342'242402.-004)1140)(1334551061*02222*,3-4/34311241521,.260+5000+,'0-2*3/344*220253+4/./4614.0.4.3(343324432232/0004/514240255.401035262--/00,-.0316444/%10164224(-3,2101,/2152150443*12214453/-4.22032454354,05.00012233/-5,20/.25425,65111432)*.533/0351/(43446252323%33233-,4+10&4'0201+10(*-324334,430230/+1031'3/53+1/.4,231502-1+211106-4,3/-03'10..1544,434111043*.(//23/06,2/2.3)13/301/+132--341(0/0,*333'//32*//)*20,1%(,1113/3133)*/*0+/%+//22+-.,-,/510-0/23305411)0(,..*/1)*3/+22/-3.0/+.1*212.4454152.05.+/0.+-)/*/'%-211/424,/12/-451/1/(501,03.34040/361../+,./14141/*4,0,1-4345/,.0352/112/1'-111./32./+,3+4/222144/,4134343.0.230143,1/1,+3).&-4.3610(+)/03-5+1.,3340104+24321/+-/2/.3410/-00//44012')&103/3(2'23021-11032).23))335//423*33,324.0203)42/+0.*03/12,$,+-1-1+32$,1/%322-,+.43.00)065/0 @rCer/1505/1740_62_CCS ATGGGGGGCATTTTGCTGCGTCACCAGCCGCCGCCCGGCCTCACCACCCCTCGTTTGCACGCACGCACGTTCATTCTCCGTCCTCGCGCCCGTTTTCCTACACTTTCCTCTTCTCCCCGACCGGAGGAGCCGCTCTTTCCGCGCGGTGCATTCTGGGGACCGAGGTCGAGCCCGCCGCTGCCGCCGTCGCCTGAGGGAAGCGAGAAGAGGCCGCGACCGGGGAGAAAACGCGGAGTCGCCACTGGAGAGAAGTCGACTCCCTAGCAGCAGCCACCGCCAGAGAGGCCCGCCCACCCGTTCGCCCGTCCCCCTGCCCCGTTCACAATGCAGCCTGCTTCTGCAAAGTGGTACGATCGAAGGGACTATGTCTTCATTGAATTTTGTGTTGAAGACAGTAAGGATGTTAATGTAAATTTTGAAAAAATCCAAACTTACATTCAGTTGTCTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGATCCAAATGATTCCAAGCATAAAAGAACGGACAGATCAATTTTATGCTGTTTACGAAAAGGAGAATCTGGCCAGTCATGGCCAAGGTTAACAAAAGAAAGGGCAAAGCTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTTTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAGTATTGTCATCACTTGGATTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAAGCAATTGATGCAGCTGTTGTGATAAATAGAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGATAACTAAATTTTAGATTATAGAACATGGATTCAAAAGTGGCTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTGTTCTCCTGGTGTTCCTTCAGGATTTTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCATATGATTCTATGTAAGTGATCACTTGTCAGTGCTCCAGGTGTATCTTAGCTAAACTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTATACATTTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGACCAGATTTGTATTTGCACTGTCAAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTATTTCTTTTTTTGATTCAGCTTATACCAGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGG + B=:;8BA>=E@BGE;F3<8D>=;??ECG>BC>?E+@=>?BB?DB==BCB>G=CDCC7FBC<AF;B?GA==FG:BEGBCA@A@7-6?>8B>>=CCGCE?B:=8:8<>>5;?=?>:?>.;703509=:6?>9A:B<@=<:>B;==<6C>8:B9>08?72?9?<;%>>;@42;<<>A:9:>A>@@:=B7>?:?>859:.;2<=?B?98><;A>?A:585:==9C998A>:;;<9?@/A;9A=?>??BA/77ACC=@?;BAA=0::@5:<:=<;>>:897;;724>/@=B=@:;:?A6@>>A?9?+A>@=7?8=5/>7BC:9:=&::=;<=$9A@;A743>,949:7@>>?;,;.6?<;>9;=,=<>=4><7:8:6=;7)6:;>?@5CAB>:AA>85=>==3;0@1AB?=C?<==>:ABB><><46@=6=A@.:BAB5;ACA=86>=>??32,AC@B=6651A?C?>93:=C4>?&>=6-77A8C??=;6;C7>@?=@AA=@@4@??97@6A=;35@<@C9@><;==2=6A>?>=BB>A==<9?AB%@;AC@:A??+AA?<=.?<-:>>/@<6?:?@?8=A=4;1<;:>:8=8;<59=;@7>47>A>==@2>:>?,;>@>>?:26;:6=>@AAA/?>@;8B@BCBC@B=6C<>=@>?48/A@@BA>49@1;649<8+77:@@8><>??(?A;?A3@;>>AAB>3A>;*9A@>3A5?>>49A:A8B;=?69<2@6B>=BCC@?>8C7A:>:A@<>:;;=@7>C><8;<<,=7<:;68BCA63<(A:<>?<5?:=??;&:?=%;?;=)2>-A8@7<<8B25>9=<=3639:791;:=>=5::8;6462?:><8973845*;374:96<>=>>;:9(969<=16;68;05:42-69<87=8;'3:<4=?:38<*6/33$7487117212/4989:639?<<6<9:1==9;:<098?498+88<7431-,&8;8-:7$<4190;;3740<892.-159)=684<==9>=;98>?:?=6<58,;<8=:,<74:83=8<48860:99?87+<:?===;;>2?<5305=<-=915<=<=17=<<<;.58,99=>>=8;::9=:>9(:<3:3<-<:47885146453-8;;?46?<=:<==;9896'62<17=;=;:?;=789(898>86689*968=;;/=>4;=69336>7=?6=:9.6488:9=:??9<69::*5??3=83;74;=26>:79:02>;:92=8>=9;84;9+8<:>8;=73<;==;:6:.9:077<7<;-6;=:98=;<;6;.>==6<=9>38>>;598>6=::=;59599;78:::$9<==/;1:6=9788?:>71>???<9::75::;:7;8%=9:0:2>>80;:;?9<:=6:7;8;;&8:<7<6;:2:<7?67468386=9<<;.238=;88+?=27>=<:=>7<8:<;.:<;/:><38<>;/97 @rCer/1509/2109_61_CCS ATGGGCTGCTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACACTGCCCAGTATATCCTGCGTGAGTTCAGGTCACGGATGCCCGGATGGGCAGTCAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCAAGACAGGCGAGGGCTCATTGACTTCATCGGACAGGTGCACAAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGGTGCACTGCAGTGCTGGTGTGGGCCGCACCGGGGTGTTCATCACTCTGAGCATTGTCCTGGAGCGCATGCGCTATGAGGGCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTACCAGCTGTGCTACCGTGCGGCCCTGGAGTACTCGGCAGCTTTGACCACTATGCAACGTAATACCGCTCCCTCTCCTCCGCCACCCCGCCGTGGGCTCCGGAGGGACCAGCTCCTCTGAGCCATACCGACCATCGTCCAGCCCTCCTACACAGATGCTGTCACTGGCAGAGCGCAGCCACGGGATCACAGCGTTCAGAATGCTGCCACACCAGTCAGAGAGCCTAGAACATCCCTGGGCAAGTGGGTGGCCTGCAGGCAGGCACTGTGGCCTTCTGTCCACCAGGCCCACCTGGAGCCCGCTTCAAGCTCTCTGTTGCGCTGCTGCGTTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAATACATTAAGTGGGGTAGACTGAGGGAATTCTAGCCTCTTCCCTCTGATTTTTCCTTTGCGAATCCATATCTGCAAAGTGGGCCCTGTAGGGGTTGGGGTTTATTTGTTATTTTGAGTTCACTTTGGATCCTCATTTGTATGACTTCGCTAAAGGACAGAACATTGCCTTCCCCATGCAGAGCTGGGCCGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCTGGGAGGCAGCGCTGATCCGGCTGCTCCTCCAGCCCTTCAGACGAAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATTTTTTTTTAAGTTTTGTTTTCCCTTAAAAGCCTTTTTTTAGGCCACATCGACAGTGGTGGGCGGGGAGAGATAGGAACACTCATCCCTGGTCGTCTGTCCAGTGTGTGTTTAACATTCACAGCCCAGAACCACAGACGTGTCTGGAGAGCCTGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAAACAAAAACCACAAATAAAAAACAAAAAAAAACAAAAAACCCAAGAAAAAATGAAGAGATCAGCCCTTGGCTTCTGCTTCAACCCTCAAGAGGGAAGCAACTCCATGTGCCTGGGGTTCCCAAGGGAGCTGCTGGCTGACCTGGGCCCGCAGAGCCTGGCGTTGGTCCCAGCATGCAGTATGGCGTGGTGTTTGTAGGCGTGGGGTCCGGCTGTGTGGCCAAGGTGATAGCACAGGTCAGGGTGTGTGTCACACCCATGCACCTCAGGGCCAAGCGGGGCATGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAAGAGCAGGGGCCAGATGATTTTCCTCCCTGGTTGCAGCTGTTTCAAAGCCCCGAGTATCGCTCTTTTCCACTCAAGATGCCTCATAAACCAATGTGGCAAGACTACGGACTTCTATCATGGTCCTCCAATCAGTCCTTATTATCCTAGCTTGCTGAGGGCAGGAGAGGCCCTCTTCCTCGGGCAGCGCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGGACGTCCCCAAACCTAGCTAGGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTCTATTGTTAAGAAAACTACAGCATCATTGCATAATTCTGATGGTAATAAATTTGAATATCAGATTTCT + 9598*7.17048)82945717478'38,895:966.5386&')*&3.-/&$+245%.045,407&:/2:(43<723$;<;><>91%249.,5#49??73.(74%/4:>67383?;66:?=?83596=;9+>47<>8=40:6<=07=/;?<9:$&'7/;99:484:2*1%7<8*70;=1674>?;97;:7884:=7$8:?>?<9-34>58<=38&7::=18849.>3;7;>8:;39><29/<66287388472/<=*4177-=3355%663*1-23207868(.91?:86>02889,285)6=>92.*03188,8<8:,15<>833978'9+2<9,<293%2096)8;>;:70.2&:>=;9289=561=6*9>9=39;2==80;87;<5=419>-;1.479>2:9<;?5<=+2=6126/$6:86974;=<07-=8874996:6,7::8#3720412:9%-27;++6.6820;:9%891;677$67))<:<=>1/;&4353808459:6=1>9823:9:<4238;*6*<8;=<9:2=:4;:>>65#.4:;%;<5441385:%26$.3656*;>28<9<29;899720/45)4=;=9989>:7:7606619:==08<697.$469,:,:,9-;/35)$6&,+:7>>?;697/2%<<3<<22:17>==+:9;317049<6;<50:0>>;84<<49>>>:824515842,51.0.+*+//1&+475&5-;:;+751&785<;;;==?091;=91>47--/967';38754=727$1#:'5-)???;.5*97)8>2;66?28922<<<8;:(9:?6.3"#-:.39>>/<7=?=078'466&28(27;:%:06;8><109&987193;9592.-5<:637;2$37868/75434<;)/04(<>-9+8<;&3:<2;=:<=892#02=?48:?<7878>;>=:198>?:?::=??:;*;<(;<+15:7;7/88+:<:-8<>>7?25:299>>+;5:;>>=8<&7:76,19<9*8:9:88;.2>;6??4:6%;886,6<:758:;'=77974&::;>.==3=;439)<=7;;:9<8&<>+8'<9=<<:3;3=9;61=;-2780,++,..,,=)-3966565062&-:273<;>::39)*0;48==<:818%+(;/0/4*.==68:7/>5,6,9=;;9=102;.0;290+,%.4)7)6/36<282.'5/5,47>?=>?;6;<<:+?6=*679)50;=;+,<<7/'7,.0<<$#7;<<=*5;;;;28;7'7><:;8-3:&?<;77679'+57(1$0%'88695(<.>4+8,:;>::=86#1?1474*3725'0,36726<:3/:=5<>1257844.<=)5-89'107/92,7+<;<9>4<>;-=<08-97/55-173=87)-,/6/(0/94#:;5-*8*6373/1(-%26'0+00-%,388:62;5778;<9:58&>19152,5/57-88::?8962;9084727<7;59*87'48:<<97567=:1:67*345/2&451088,?7?8=?978;+7<,89.7-1)464&/'22&)-3),3/$+3:/+'0,-01)4;5966:91:-;238::140&8463:0<:36$6<584849:$5>;77:67$73/102=7;78<98*=7:<9$.0::55;%*31;9:):0;&495:481'19:67$00&/818;878$0;>;?92:5<229>:<;:96=:7.,215+7=?5<<8<486*0-8%4657264/55734(2&09%80,33/+,.90(13428748-1+::67,4793*2,68,-02.4.89,4631$21154(,,$894.6-307&&$3:6-489+30%7/4(9:11912'3%503925579;8649*:1389-6(7(*0&279.:40:85744:4946.1+9:8$3:5;986650&21346/-735428-2516.4-58.13.464-,/03086$,.0-&.5++)1/-1#2(///10/4130&54004**'(&0./1+),(/0-+./&0,&$(&.-//0,(/0 @rCer/1510/1916_57_CCS ATGGGGACTTGCAACCTGCAGAGGCCCGGAGAACACAACCCTCCCGAGAAGCCCAGGTCCAGAGCCAAACCCTCACTGACCCCCCAGCCCAGGCGCCCAGCCACTCCCACCGCTACCATGGCCGAAGACGCAGACATGCGCAATGAGCTGGAGGAGATGCAGCGAAGGGCTGACCAGTTGGCTGATGAGTCGCTGAAAGCACCCGTCGTATGCTGCAACTGGTTGAAGAGAGTAAAGATGCTGGTACGGACTTTGGTTATGTTGGATGAACAGGAGAAACAACTGGAACGCATTGAGAAGGGATGGACCAAATCAATAAGGACATGAAAGAGCAGAAAGATTTGACGGACCTAGGAAATTCTGCGGGCTTTGTGTGTGTCCCTGTAACAAGCTTAAATCAAGTGATGCTTACAAAAAAGCCTGGGGCAGATAATCAGGATGGAGTGGTGGCCAGCCAGCCTGCTCGTGTAGTGGACGAACGGGAGCAGATGGCCATCAGTGGCGGCTTCATCCGCAGGGTAACAAATGATGCCCGAGAAAAATGAATGGATGAAAACCTGGAGCAGGTGAGCGGCATCATCGGGAACCTCCGTCACATGGCCTGGATATGGGCAATGAGATCGATACACAGAATCGCCAGATCGACAGGATCATGGAGAAGGCTGATTCCAACAAACCAGAATTGATGAGCCAACCAACGTGCAACAAAGATGCTGGGAGTGGTTAAAGTGCCCACCCGTGTTCTCCTCTGAATGCTATCGGGCAAGATAGCTCCTTCATGCTTTTCTCATGGTATTATCTAGTGGTCTGCACACATAACACACATCAGTCCACCCCCATTGTGAATTTGTCCTGTGTCATCTGTCAGCTTCCCAACAATACTTGTGTCTTTGTTCTCTCTGGGTCTCTTTCTTTTCCAAAGGTTGTATATAGTGTCATTTGGTGGCTCTAACTCCTTGATGTCTTGAGTTTCATTTTTCCTTTTCTCTCCTCGGTGGCATTTGCTGAATAACAACAATTTAGGAATGCTCAATGTGCTGTTGATTCTTTCAATCCACAGTATTGTTCTTGTAAAACTGTGACATTCCACAGAGCTACTGCCACAGTCCTTTGAGTGTCAGGCTCTGAATCTCTCAAAATGTGCCGTCTTCGGTTCCTCATGGCTGTTATCTGTCTTTATGATTTCATGATTAGACAATGTGGATTACATAACAGGCATTGCACTAAAAGTGATGTGATTTATGCATTTATGCATGAGAACTAAATAGATTTTAGATTCCTACTTAAACAAAAACTTTCCATGACAGTAGCTACTGATGAAACAACACACACACACATAAAACAACAGCAACAACAACAGAACAACAACAAAGCATGCTCAGTATGAGACACTGTCAAGATAAGTTATACCAGCAAAAGTGCAGTAGTGTCACTTTTTCCTGTCAATATATAGAGACTCTAAATATAATCTCCTTTTTTTAAAAAAAAGAATTTTTAAAAAGATGGATTTGACACACTCACCATTTAATCATTTCCAGCAAAATATATGTTGGCTGAAATTATGTTAAATGGATGTAATATAGGGTTTGTTTGCTGCTTTTGATGGCTACGTTTTGGAGAAAGCAATCTTGCTGTGAAACAGTGTGGATGTAAATTTTATAAGGCTGACTCTTACTAACCACCATTTCCCCTGTGGTTGTTATCAGTACAATCTTTGTGCTTAATCTAGAGCTATGCACACCAAATTGCTGAGATGTTTAGTAGCTGATAAAGAAACCTTTTAAAAAATAATATAAATGAATGAAATTAAACTGTGAGATAAATATCATTATAGCATGTAATATTAAATTCTCCTGTCT + 14555*2113655164604.//6466-63)04'.10+%56/+23&2()6.)45)46314%-2614(66.0+#/3.04000.010%0(04)06/0.23(%/63//,23%+/&..043/043,+.)2(&'1512-05-)42521*.1,-+565560430(3216622.02011/.3*213/2&44-/642/05313$&-$-3*-0%,*0.-,1.--102-.*202.1.,-+.--0.,,0-+,*101)"$*+-0./*1.2/0-.1+2-%+01+,'.$'(&/&11+/00,0**('*2--,',)11,0...1,'.**-'+++0-.+.10-0/0+)$))-*-.$.&(,'+-00,-+(1///.*$++'(01--,,10,0-+,.1./0,)(.*/',.%/01,//&10+%.*(*),,0).,,-...%/2.12000.,'+,,+.10+01/0'.(#,*,2,++,.,'----+/.1/,+1(,011*)&..&+11---1,*/12.210(0+.00*12.,1-0-1/-1*.*0-+0,122.1+,*-,,%01-)),,#0*($020,,,)).&1-/,*)+-/-.-,,-120/$.,)*110,2/2-1210+--.---(*%,)&()0/10*11*(,,(,1..0-0*'(&01.11*1+00'0/1)(*/,,&&//+/1*-(+%*1,,)&-++(%+)&+(,),(-,--&,+'((-,.--)-*,---)+-,(,)($+&)'#%#--'*(-(#()(-+'+&*(,,*)&''+++,)--+%#,-((+-.,--+*--*',*-(-(-,*-+,('$&$#++-),),&+,*+',$)*',,*,+'(%%*---,(+*(()--,-(&+--*()''+,)%##+(,+,))--)/.-.-&/*-*.-+(-0(/))0+11.-',1/-+(.%*-,-+&,*'-.)&,'(11)/.//&1+00).'/.11/,,(-/'$./++.$20-201-0+*-112//&.,++/-0,,*,.0).10/-/%0-/--&-+11.*--1+-.(--0.*/%,11-12002/0-)+0&-2235100110+02*.-262-0*,$/)5.43'562052410*)*-,,1,52443)316/2/116/2(2,*30..4+2141%04,4361+1.51+024402)/2..+(%/0/55511,#-,2//,.-/6151,.'-+'+)*)(155-.,/*032/4,(((-+-2$,/451531*+&,),.31-$(-121*1'5324/-*+10,/,.,+)*,-)$,*.-11-/42/111,,..**+/,11++**)(/,0/1//+0110.-.,&-0,/0../...&0-+,2-0)(&011+,0%*0/+)++(2.01/---11.'*0*//1.00.)*)'-,,120.0-0-'-.*/)/2-00*-22+,,)11+&/-+0)&*',,+)-++.+/,,/(-+&0()+*,,01/222+))0/--,*1,,'1/1-,..(/.+1.12*.,/+*+(,,,*#+-..+$%,.-,%'-****++)"(,(*,,,%**&*,,*%+--''+)).,--*',*+&(+)$)-.,'(-*-)---..-.---)%&*')&$%&#,$$$,((,-'))+),+*..,--)-,((-,*$)*(&,.-,,,-(&#&-,+**$(,)&&*-(()(),&,%+,-(*-,.,((&#%,----,-))(--*-)*-+)(,+'-+,'*+-),,*+)-+,++(,,),))(,+'(++(),)(),'+(,'$(&+(,,--+)($$&,,(($+(-,-)-,-,(,(,))&'()*'--..,())*)(,+)+(-,%%,+',+()'',.+-.(++),+)%(+++)$$*#$&)(+%,*.,(,-()$)*-(&,,(,-,'),*%,--*(+'(,-)(,,-*--,,-(,-%*&%)**))),' @rCer/1512/1681_56_CCS ATGGGCTTCCTCACTGGGTTGCTGTTTGGCTCGGTGGTCATCTTCCTCCTGTGCTACCGAGAGCGGGTGCTAGAGACGCAGCTGAGTGCTGGGGCGAGCGCGGGCATCGCGCTGGGCATCGGGCTGCTCTGCGGGCTGGTGGCCATGCTCGTGCGCAGCGTGGGCCTCTTCCTGGTGGGGCTGCTGCTTGGCCTGCTGCTCGCAGCTGCTGCCCTGCTGGGCTCCGCACCCTACTACCAGCCAGGCTCCGTGTGGGGTCCACTGGGGCTGCTGCTGGGGGGCGGCCTGCTCTGTGCCCTGCTCACTCTGCGCTGGCCCCGCCCACTCACCACCCTGGCCACCGCCGTGACTGGTGCTGCGCTCATCGCCACTGCCGCTGACTACTTCGCCGAGCTGCTACTGCTGGGGCGCTACGTGGTGGAGCGACTCCGGGCCGCTCCTGTGCCCCCCTCTGCTGGCGAAGCTGGGCCTTGCTGGCACTCTGGCCCCTGCTCAGCCTCATGGGCATTCTGGTGCAGTGGCGGGTGACAGCTGAGGGGGACTCCCACACGGAAGTGGTCATCAGCCGGCAGCGCCGACGTGTGCAACTGATGCGGATTCGGCAGCAGGAAGATCGCAAGGAGAAAAGGCGGAAAAAGAGACCTCCTCGCTCCCCCCAGAGGTCCCCGGGCTCCTCCCAGGCCTGGGCCCCCAGACCCTGCTTATCGGCGCAGGCCAGTGCCCATCAAACGCTTCAATGGAGACGTCCTCTCCCCGAGCTATATCCAGAGCTTCCGAGACCGGCAGACCGGGAGCTCCCTGAGCTCCTTCATGGCCTCACCCACAGATGCGGACTATGAGTATGGGTCCCGGGGGCCTCTGACAGCCTGCTCAGGCCCCCCGGTGCGGGTATAGCCATATCTGCCTGTCTAGACTCTGCCGTCACCAGCTCTGCCAGCTCGGGGAGGCCTGCTAGGCTGCCACTTAGCCCCCTGGCTTTGGCTGTCCCTCTCCCCAGCCTGGAGAGGGCTGGCCTGGTCACTAGAAGGGAGGATTGTCTCAGGCGAGTCTTGGCCTGAGAGGAAAGCCCCCTCCCAAGCTCCCAAGAGGCTCCTGAGGAACTCGGGGTGTGAACCCCATTGGGGTGTGCTCAGGGTTGTGAGTGTGTTGCCCGTGTGTCTGTGTGTATGTGTGCAGGGGTGGGCGGGCTTGGAGGGGACGCTGGGACCCTTGCCTTAGATTTCTGACTGGTAGGGTTTCTCCAGGCTCAACCCCACCTCCTCACCCCCGCCGGGGTCCCATGGGCCACCTCCTGCATGTCTCCGCGGAGGGGCTACCTTCCTTCCCATCGCCCTGCCTCCAGCCAGACTCATCTAAGGGTTCTTGTCCTAGTCTATGGGGCAAACTGTAGCACCCCTCACCGTGGTCCCCTGGCCTCTGCAAAGCCACCAGCCTGAGGCAGTGGCAGGAGATGGGGGTGGGGGGTGCTGCTCTGGGCTGGGTTGGGAAGGGAGTTGGGGAGGGGCTGAAATGCACGGTGCATGTCTGGTGTCTGTCATGCCAACCTGGACACCTCATGCTTCTGTCTCCCCCACCCCACTCTGTTTTACATCTTTTATAAATGTGCCAAACTGCGTGGCCTCTGC + IJJKHKKCKIKKKKHHK:KFKKJKKK@KJIKKKGKKHKKJJJKJKKJKJKIDJKIKK7KKJJBJJK@KJKKJKKJGKKKGKKJKKKKKKKKKK6JKKKKKKKK?EKJJKKKKJKJ2JIKKKKKKKKKKKKKKK?KKKKKIKKKKKKKKKKKKKK?KKK3IKKJKKBFKK3KKJKJKKJKKDKKHJKJKKJKKKKKKKKKKKKKKKKKKKK@KJKKKKHKKKKKKKKKKKKKKKKKKKIKKKKK3KKKKKKKKKKIK:KKKKJKKKKKKJKKKKKKIKKKKKKKKK%KKKKKKKKKKKKKKKKK@KIKJKKKKKKKKKKJKKKKK(IKKKKKKKJKKKKKKJKKKKKKKGKKKKKKKGKKKHKKIKKKKKKKKKKK=KKKKKKKKKKKKKKIKKKKKAKKKKK7K;KKKKKKKKKKKKKFKKKIKKKKKKKKKKKKIKIKGKKKKKKKEHIKKKKJKKKKKKKFK;KKKKKKKKKKKKKKKDKJKKKKKKKJKKJKKKKKKKKKKHKKKKK;KKKKKKHKKBKKKJKKKKKKHJK7KKKBKKKK/KEKKKKJKKKFIKKKIJKKKKKKKK,KKKKKKKIJJKGKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKK@GKJKGJKKJIKIKKKKKKJKHJKKKKK.KKKJKKBKIKKKDKKFKKKKKKJKHKHGKKKKKKK*KKKJKJKKKKKKKHKKKJKK7JK.KKHHKKKKKKFKKKKKKKJKHKFKKKGJK=KKGFHKKK(EKK2KAKKKKK>KJIKKKKKKHKKJKKKJDJKKKJ:9KKKKCKKK&KKJKKK;KKKJKKKJJJ?H=IKKKKKHHKK4JJKFIC@KKKKJHJJKJFKKIDG:IJHKJK7IJJ4FKK.KKIGGGKJJBIKKJKKJGJKKJKKIK>KKJKKKKDJKKIJIKJKIKKHKKDIHKDIKIIKJKGHKK2HKKKKHJKKKJHK#>84A>8;JJJ?JIIJ>E/=E2JF8KGKHEJJIAFHKKKHKKKK)JFJKDKJKCKIKKFHKKKKK4KJKJKK%FIKAJIKKKKKJKJKJKKEKJHK?J=K@KBJJBKJJKKI-FKKAJKKKKJKIKKK)KJKKGJJKGIJKK8JKEK8KKKKKKK>GJ8IKKJJKH@JJJ%HJJKKHKKKKKKKJKJHK:KKKKJK8KJJKKJKJJKK8IHIH/KHKKEKFKKDJHKIKKK?KKKK>KGKKKJJJICIKFJJKJKKKKKK@KKJKJKHJKHKKFKBKBKKEKKJJIJJHKKJKEKIJJIJJKKK7HKKK1JJKKKGKKK8KKKKKKKK?KJKKHKKGJKCKKEJJKKKKKHKJKKJJK @rCer/1513/1807_60_CCS AGTCTCCACCCGGACTCCGCCATGTTGGGTCTTGTGGGTCGTGTGGCCACTGCTTCGGCCTCCGGGGCCTTGCGGGGACTCACTCCTTCAGCGTCGCTACCCCCAGCTCAACTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACGGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTTATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAACAATTTGCTGCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTGGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCCGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCTGGTATATGGTCAAATGAATGAACCACCTGGTGCTCGTGCCGGGTAGCTCTTACTGGACTGACTGTGGCTGAATACTTCAGAGACCAAGAAGGTCAAGATGTACTGCTATTTATTGATAATATCTTTCGCTTCACCCAGGCTGGTTCAGAGGTGTCTGCATTATTGGGCAGAATCCCTTCTGCCGTGGGCTATCAGCCTACCCTCGCCACTGACATGGGTACTATGCAGGAAAGAATTACCACTACCAAGAAGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTTGACTGACCCTGCTCCTGCTACTACGTTGCCCATTTGGATGCTACCACTGTACTGTCACGTGCCATTGCTGAGCTGGGCATCTATCCAGCTGTGGATCCTCTAGACTCCACCTCTCGCATCATGGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAAATCCTGCAGGACTACAAATCCCTCCAGGATATCATTGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACTGTGTCCCGTGCACGGAAAATACAGCGTTTTTTGTCTCAGCCATTCCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGACCATCAAAGGATTCCAGCAGATTTTGGCAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATGCGTCGTGAGGGGTCCTTGTCCTCTGTACTGTCCCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTATCTGTGTTGGCTGCACAAGAGCCTTGATTGAAGATATATTCTGTCTGAACGGTATTTAAGGTTTCCAATAAAATGTACACCC + 9786894:?<6;1:72:5;72;>:=7:8&0776;;:=988;=>865:49;6798649/?17979;;-=6<28>?=<2>=3<421:9;->;68957>==:9569(9;;9;=,>>>95:5:>==:-9;=<>?9+;>=<>=81>98596<:<>:9:1<8:=95<:;8>;<8,9;>>*:86599;:=;85;78(5<=6=?7>?9;832<;:7>>9?:=<<=99;==979;=>=?7<:;65>=?<>9?=./3:77;>/3(6;=64:793=3:5778.787.4/&9+/4/5228419::-6.452898803*9;;67/384843770015652%+--)-0/)-3575::;8:5650395:958:;425249459.747399.6776977;99::875-7404297392.44+40638%9542:;75:/.%767*:3/:539856497137%87194687026066;74227,89:/9255;:953::5/599227755:9768(71:$695996963771571498::1533355;886337+994:5;;25529965&953:9;:988;879:1)27904/464131:384..74814885909249;36777207789658196:93;69:/7:998#/147683:292/9746/8;86(3558:6360:7-31&5.:8917661898:9289;337'045(73;98984'4/66214699*7,6:79934:05389993/29*565928389559873../-0/6768668:2996858719995;69402-62+455*71188+76414985;9::8815572'33/5867467.8:;888844+//*4974,5++6,38+6:28762/8329:5:61784594879635:;68799.696559:/:15966759544216355+193879992574471*26555-4968136:7559876;5;7:6539579359:7551-:369)71/53567+;9:596+::;;45659898;:::;6322,466444768866*27959:7:6:355.5356544252-01*5*11,5%45654664224144552560235564434056454432-31531+*05461.2)42555(44//30+2-(3$-33-3660634150153444133113152561006552.2446553556505264334,1314335.514,562.22.36156551.5444464563416604*366555150213(352+05-45-22/1(.2/,+4466054424655(4633120.0,*-2350.455*34-0403./46665660,564021'34+6155463550+5/4141603265444)424640-2565410/4622322,/16466466466-664145/64122615526126566230565645564.112..115(624153-)3414+33-%3.54.20.132/14.16122563332666065402*442-1230450*04112-*%4%44636451331542603651362166530.10+12-34615666165251464-256/535655*425-3456653006441/505155513.15251(.456045340404543'.61-2+0566,666154440015534/3-2+5223*560020646.566544*2*51556405545143416/456625-634606163656651632/2454 @rCer/1514/25_2958_CCS ATGGGGGAACTGCGGTTGCTTCTGCAGCTGAGGTACAGCGGCGGTTTCTGAGGCTCCTGACCGGCGACCACGGAGCTGCCGTGGCGTCTTCACACGCAACCATGAAGTTGAAGGACACAAAATCAAGGCCAAAGGCATCAAACTATGGCAAATTTCAGACAAAGGGAATCAAAGTTGTGGGAAAATGGAAGGAAGTGAAGATTGAACCCAAATATGTTGCAGATGGACAGATGGATGATTTGGTATGCTTTGAGGAATTGACAGATTACCAGTTGGTCTCTCCTGCCAAGAATCCCTCCAGTCTCTTCTCAAAGGAGGCACCCAAGAGAAAGGCACAGCTGTTTCAGAAGAAGAGGAGGAGGGAGAGTCTAGCTCACCAAAGAAAAAGATGAAGTTGAAGAAAAGTAAAAAATGTAGCAACTGAAGGAACTAGTACCCAGAAAGAGGTTGAAGTCAAAGATTCTGAGCTGGAGGCCCAGGGAGATGGCATGGTTGTGATGATCCGGAGGCTGGAGAGAAGACATCAGAAACCTGGTCCAAACTGCTCCAAAAAAGAAGAAAAATAAAGGGAAAAAAGGTTTGGAGCCTTCTCAGAGCACTCCTGTTAAGGTGCCCAAAAAAGTGAAGACATGGATTCCTGAAGTTCATGATCAGAAGGCAGATGTGTCAGCTTGGAAGGACCTGTTTGTTCCCAGGCCGGTTCTCCGAGCACTCAGCTTTCTAGGCTTCTCTGCACCCACACCGATCCAAGCCCTGACCTTGGCACCTGCCATCGTGACAGACTGGACATCCTTGGGGCTGCTGAGACAGGAAGTGGGAAAACTCTTGCCTTTGCCATCCCAGTGATTCATGCAGTATTGCAGTGGCAGAAGAGGAATGCTGCCCCTCCTCCAAGTAACACTGACGCATCACCTGGAGAGACCAGAACTGAGGCCGGAGCTGAGACTGGATCACCAGGCAAGGCTGAAGCTGAGTCTGGAGCATTGCCTGATGATACTATAATTGAGAGTGAAGCACTGCCCAGTGATACTGCAGCTGAGGCCAGAGCCAAGACTGGAGGCACTGGCTCAGACCAGGCATTGCTCTTTGGTGACGATGATGCTGGTGAAGGGCCTTCTTCCCTGATCAGGGAGAAGCCTGTTCCCAACAGAATGAGAATGAGGAGGAAAATCTTGATAAAGAGCAGATGGAAAATCTAAAACAAGAGTTGGATGACAAAAGCGCACCTGTAAGGCATATCCAAGCGTCCTCTGCTTGGACTGGTTCTGACTCCCACTCGAGAGCTGGCTGTCCAGGTCAAACAGCACATTGATGCTGTGGCCAGGTTTACAGGAATTAAAACTGCTATTTTGGTTGGTGGAATGTCCACGCCAGAAACAGCAGAGGATGCTGAGCGTGTCCTGAGATTGTGGTTGCCACTCCAGGCCGGCTGTGGAATTAATTAAAGAAAAGCATTATCATTTGAGAAACCTTCGGCAGCTCAGGTGCCTGGTGGTGGATGAGGCTGACGGATGGTTGAGAAAGGTTCATTTTGCTGAGCTCTCACAGCTGCTAGAGATGCTCAATGACTCCCAATACAACCCAAAGAGACAAACGCTTGTTTTTTCTGCCACGCTCACCCTGGTGCATCAGGCGCCTGCTCGAATCCTTCATAAGAAGCACACCAAGAAAATGGACAAAACAGCCAAACTTGACCTTCTTATGCAGAAAATTGGCATGAGGGGCAAGCCCAAGGTCATTGACCTCACAAGAATGAGGCCACGGTGGAGACGCTAACAGAGACCAAGATCCATTGTGAGACTGATGAGAAAGACTTCTACTTGTACTACTTCCTGATGCAGTATCCAGGCCGCAGCTTAGTGTTTGCCAACAGCATCTCCTGCATCAAACGCCTCTCTGGGCTCCTTAAAGTCCTTGATATCATGCCCTTGACCCTACATGCCTGTATGCACCAGAAGCAGAGGCTCAGAACCTGGAGCAGTTTGCCCGTCTGGAAGACTGTGTTCTCTTTGGCAACAGATGTGGCAGCTCGGGGTCTGGATATTCCTAAAGTCCAGCATGTCATCCATTACAGGTCCCACGTACCTCGGAGATTTATGTCCACCGAAGTGGTCGAACTGCTCGAGCTGCCAATGAAGGTCTCAGCCTGATGCTCATTGGGCCTGAGGATGTGATCAACTTTAAGAAGATTTACAAAAACCCTCAAGAAAGATGAGGACATCCCGCTATTCCCTGTGCAGACAAAATACATGGACGTGGTCAAGGAGCGAATCCGTTTAGCTCGACAGATTGAGAAATCTGAGTATCGGAACTTCCAGGCTTGCCTGCACAACTCTTGGATTGAGCAGGCAGCAGCTGCCCTGGAGAATTGAGCTGGAAGAAGACATGTATAAGGGAGGAAAAGCTGACCAGCAAGAAGAGCGTCGGAGACAAAAGCAGATGAAGGTTCTGAAGAAGGAGCTGCGCCACCTGCTCTCCCAGCCGCTGTTTACGGAGAGCCAGAAAACCAAGTATCCCACTCAGTCTGGCAAGCCGCCCCTGCTTGTGTCTGCCCCAAGTAAGAGCGAGTCTGCTTTAAGCTGTCTCTCCAAGCAGCAGAAGAAGACAAAGAAGCCAAAGGAGCCGCAGCCGGAACAGCCACAGCCAAGTACAAGTGCAAATTAACTGCCCTGGTCAAGTGTGTTAGTGACTGCACATTGCTCTCTGTTCTCTGGCTATTTGCAAAACCTCTCCCACCCTTGTGTTTCACTCCACCATCAACCCCAGGTAAAAATGTCTCCCTCTCTTCTACTCACACCATAGGCGGGAGAGACCTCATGCAGATTTGCATTGTTTTGGAGTAAGAATTCTATGCAGCAGCTTAATTTTTCTGTATTGCAGTGTTTATAGGCTTCTTGTGTGTTCAACTTGATTTCATAAATTAAAAACAATGG + +(#%%*(),,-&$&)&,+)(--,,---+('&+-,-+(*--.-),*.-)+---.,-+.----.-.--+,+%').,+--+#**+#'',))$)*)'',,*,.,-),--.,(,*(,+.--,%+-..-(',+-+*(--(+(,-,(,,,--)+.,(,,,..--,')))-,,.,.,(*..-+-)*%)($(()),-(-,.)*,,,',')(,,&+(+,,..---,$,+-,)(,+.,-,---+-&,-+)--)-,,--+&,-))((#&&'+----*-.,%%)(&)&%(,-,-,)--*.,.()---..-,-''*)&)-.-*+-..,.-+-#((),+-),--..,.-*+#*--))--,),))(#'+,)'(+.+(-,(,(,--,-,--+,,-&(,+*----(,--),,&,*(,*(+,,,+$*)*)&),)($)&+,--,.)--.----,)+.-)($-,+*+.,.--.,&(%,,,**---,),---,-(*+,.-*---*,-,,--+'&#,*)+*',-,*-,.-,-+$*-&*-)*-)-,---)+',-,.-),&+.)-----*,-*'---,,-*.-*--+))',++,.%,,,,+*)%),+-&,-.,.,-,+,),-*,*,-),,.-.-.,(+.-&,,,,,,-+(-,),-,+---.-.----',-+))')----),,,---+)**--*---+.,,,-'/.'-/+-0/+./)1/.*/,-00*//,...01-/./-*000121+'(-/(0/.0101102.00/-+*-.(*+-.%--00/,0+-%//11000',(%#+/0+-.0/-/*/+,//'+,0%-+(*+-,--/..').0/1./,2-+1001/0/21*0)0//.01.&..0/110$/./1+-01-0.-+*+0,).'/0/10*+0.2-/-/.+.(..,.,'&$/.+-0-/0/0-1/)0'+-010,111.*,/2-.&/0110(2*/,0,11.110010+1-0&(*+*%--+--/.,0*00,011(.0110011--0+(-)/-1110..,/1.1,*-.1.11112.010/1/22./1/-0-11.-,-(.-.',,.-.-%)-''($',,1,*,1,0112'.-//.+/*+/-000,+,,*00+,,(+,--./,*+*-,(.,'0&.++.&,)).&++,./0'1-.../+-,'('+-.(+(%)+,+&),--,**&%*)**%)%),,)((+)--+..-+*,,,'$*-&+,,,,)'+-*&),,(,)-()'**&((---,))#'*-'))(,&*&(+(*''#+)-,)%)*)++(**+-*%*)&$)(-+,(,,.,----,*------.,--))-+,-(+,..-,--,),)-++),**++()'*))*&*,*+)'*'*+,#,,,(++&#'#)*(&%'+),*$'(+(+%'(())$****-.*++%'+*(*+,)%%)&$#))#+%)*((,***+))*(('&++,-+.-+-(,((),,)#*$,+-'*'+)--,&,+,+--*.---)&,,,*$#%+(+(-,)($**(*(''*+)',,*'-,,+**)))&'+)+*)#'*()+,'))*,(,,,.%+-,',+&&')**,'&')()()*+,-,*))'%%()++)*,+-,*$'--,.--,&'(,,(---,--,&+*(,*,-)$*+++))*,)-----,---*.-,)$+-,-,)(--,(*(+,(+'#*'+.-.-)$*,-+.------.,.-+..-((,,+$*+,*-(+.+-,,$-+().-.--.-----,)--*()*.----)'--,,',+),().,-)+*,.---.----)'#)----,.+.-,,-(,.-*---,---,&'*'(&),.-,--.-+.,)*----)+*)(,,+..*+*-.--,),,-,''%',-.***)*()-------,+',).--,(+-.*-,+%-++-.,,-----+('*-(,--)*#++)+,-'($*-)--+-*.,.+-,&,+.-,--,-,--)*$++*.-,$))(',-+-)-,),+()+--.+,+.-,--)+-,+*,+#+)-')-,+,-,),,,,..,--(&,+.,),*(&'-.,')%(++.,-.-----,)'+),----,*.,-,-*----).,*--.-,-+.---+),+,((+.,--(#*),)&)**,-,*,,+--,+--+.,---+-,--.-,-(++,(,*,.,&,,,,(,---*,.+*--'-(++-,),+(,*&*)+(+,),.,,-'.-))))*-,)+,*-,-($-&#+)(,,--..,($++++)--*+$,+-..-*---&+*,-)$((---,),*..-------,'%,++,--*+(----+)-,''-+.*(,--.))--+.-(,,,,-----))----)--,,)*--+,)+$$%)').-.-,.-+.,'),)----.--+)+%*(**+,--,%----)(+*'+&,)*$%('#&+.,-+--)($+((+)-((,-,),,,(+-,)+(--,('%+-+-($'+-(,.---,+)+)++--+#*)()*(++*-+.--*.---'*--.,,----+(*)+*(-)-,-,+(++,-)-,,-,&,+,-*-,---,.--+,..*-,)-)+,*..----,-*+-)--,-&#()'%(+,,(,-(+-,,,-)-,()-+,%++-------,$$'&)-,.----*--+--.-,*,,()---.--.-)+$++((,((-(--(,(+-.,-,,+-(+)+,--,,&+),-.-.-,---,-,&))*()('--,-,..)-.+(%,,-,)(+,,-,--,,,%&,,(,,-,,()-,*+--+)+.,--,.,,--...-,+,,'--(&,,,.,,*,..---,)++)+(,---&,*-,'+,(-,*-,'((,+%--,-,,-*+-,()(++&+(+(%*,-..-()--,-,-,-+---)+..)*+),+(--,+.,-)(,,,.,-()+----+(--*--),'-,-+)*#)-*.----,---*-+(,-+&*+)-,+-+-*.,','',(')+--+(*.-',&+,--,+.--. @rCer/1515/2303_57_CCS ATGGGGGAGGAAGCGGAGTAGGAAGCGGCCGCGATGTCCTTTTGTGTCCTACAAGCAGCCGGCGGCGCCGCCGAGTGAGGGGACGCGGCGCGGGGGGCGGCACGGCCCGAGGAGGCGGCGGAGGAGGGGCCGCCCGCGGCCCCCGGCTCACCCCGGCACTCCGGGCCGCTCGGCCCCATGCCTGCCCGAACGCCCTGTCGGAGCCCCAGGTGACCAGCACCATGTCCAGCCAGGTGGTGGGCATTGAGCCTCTCTACATCAAGGCAGAGCCGGCCAGCCCTGACAGTCCAAAGGGTTCTTCAGAGACGGAGACCGAGCCTCCTGTGGCACTGGCCCTGGTCCAGCTCCCACCCGCTGCCTCCCAGGCCATAAGGAAGAGGAGGATGGGGAGGGGGCTGGGCCTGGTGAGCAGGGCGGTGGGAAGCTGGTGCTCAGCTCCCTGCCCAAGCGCCTCTGCCTGGTCTGTGGGGACGTGGCCTCTGGCTATCACTATGGTGTGGCATCCTGTGAGGCCTGCAAAGCCTTCTTCAAGAGGACCATCCAGGGGAGCATCGAGTACAGCTGTCCGGCCTCCAACGAGTGTGAGATCACCAAGCGGAGACGCAAGGCCTGCCAGGCCTGCCGCTTCACCAAGTGCCTGCGGGTGGCATGCTCAAGGAGGGAGTGCGCCTGGACCGCGTCCGGGGTGGGCGGCAGAAGTACAAGCGGCGACCAGAGGTGGACCCACTGCCCTTCCCGGGCCCCTTCCCTGCTGGGCCCCTGGCAGTCTCTGGCGGCCCCCGGAAGACAGCCCCAGTGAATGCACTGGTGTCTCATCTGCTGGTGGTTGAGCCTGAGAAGCTCTATGCCATGCCCGACCCCGCGGGCCCTGATGGGCACCTCCCAGCCGTGGCTACCCTCTGTGACCTCTTGACCGAGAGATTGTGGTCACCATCAGCTGGGCCAAGAGCATCCCAGGTTTCTCATCGCTGTCGCTGTCTGACCAGATGTCAGTACTGCAGAGCGTGTGGATGGAGGTGCTGGTGCTGGGTGTGGCCCAGCGCTCACTGCCACTGCAGGATGAGCTGGCCTTGCTGAGGACTTAGTCCTGGATGAAGAGGGGGCACGGGCAGCTGGCCTGGGGGAACTGGGGGCTGCCTGCTGCAACTGGTGCGGCGGCTGCAGGCCCTGCGGCTGGAGCGAGAGGAGTACGTTCTACTGAAGGCCCTGGCCCTTGCCAATTCAGACTCTGTGCACATCGAAGATGCTGAGGCTGTGGAGCAGCTGCGAGAAGCTCTGCATGAGGCCCTGCTGGAGTACGAAGCCGGCCGGGCTGGCCCCGGAGGGGTGCTGAGCGGCGGAGGGCGGCAGGCTGCTGCTCACGCTACCGCTCCTCCGCCAGACAGCGGGCAAAGTGCTGGCCCATTTCTATGGGTGAAGCTGGAAGGCAAGGTGCCCATGCACAAGCTCTTCTTGGAAATGCTCGAGGCCATGATGGACTGAGGCAAGGGGTGGTCCTGGTGGGGGTTCTGGCAGGACCTGCCTAGCATGGGGTCAGCCCCAAGGGCTGGGGCGGAGCTGGGGTCTGGGCAGTGCCACAGCCTGCTGGCAAGGCCAGGGCAATGCCATCAGCCCTGGGAACAGGCCCCACGCCCTCCCCTCCCCCCTCCTAGGGGTGTCAGAAGCTGGGAACGTGTGTCCAGACTCTGGGCACAGTGCTGCCCCTTGCAAGCCATAACGTGCCCCCAGAGTGTAGGGGGCCTTGCGGAAGCCATAGGGGGCTGCAGGGGATGTGTGGGAGGCAGAAGCCTATCTCAGGGAGGGAAGGGATGGAGGCCACAGTCTCCCAGTGGGTGATGCTTTTGCTGCTGCTTAATCCTACCCCTCTTCAGAGCAGAGTGGGACTTGGAGAGCAAAGGCCCATACCCCTTCGCTCCTCCTCTCATCATTTGCATTGGGCATTAGTGCCCCCCCTTGAAGCAATAACTCCAAGCAGGCTCCAGCCCCTGGACCCCTGGGGTGGCCAGAGCTTCCCCATCAGCTCCCATCCAGCCTCCTCAGGGGGTAGGAGAGCACTGCCTCTAAGCCCTGCAGAGCAATAACACTATATTTATTTTGGGTTTGGCCAGGGAGGCGCAGGGACATGGGGCAAGCCAGGGCCCAGAGCCCTTGGCTGTACAGAGACTCTATTTTAATGTATATTTGCTGCAAAGAGAAACCGCTTTTGGTTTTGAACCTTAATGAGAAAAAAATATATAATGTCGAGC + 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@rCer/1517/25_1569_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTAATCCGGCGCTATAGACGCAGTACGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCATCTATTGGCAAATAGTGGGAAGATTCTGGGTAGAGGTGACAAGCCTATCGAGCCTTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGTAAAACCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAGCCCATGCTACCTTCACTGTTAACCCACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGTCGGTTTCTATCATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTGT 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@rCer/1521/0_1795_CCS AGACCGGCGTCCGCCCGCGAGCACAGAGCCTCGCCTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCAATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGTGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACAATTAAGGAGAAGCTGTTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCTCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCTT 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S,,*,"',,+*+,%++')*.,+)*++*,$///.))#-()+-*'+-0/3-/65-)452.+34/3/1.--47375679%5789725',26.2/,0$*122236+)4484*48-9:3164/3.1-48/-50->576;1=),701=153949:6>97%768738<678/837535815:0166$.17701.65.'431))13+99428-23,101382:<898(7;;8>-321:8840,971396/6495)9.8275223.7=7:70987431)5'/6125(22,41244332&2<4;9'25+017245586==717/879888?<;BCA=<4-=A=?@?2=49<9<5:8>6=<=:=??A9:@2:7>:C=;<7?*9784>?@>8<>B>4:;898924:&15:;8682>3B9:/48=6:'9050-)0258=5:?816:499A9;..+77-582:9,86%711%*&-:<:@;>&6;=6*50409?+7;=.7-755442765;A8@<(?D:28A=5??=8-'*05=479:817-59@<6C2B8:;<$)+,19-6;<:73<>:5.-;4499:3;:<2A<)0466/>:2,5:=;=>64<:36C-2;>=8-8?@;8=5591=@>=7A6/5,&47891*5(%452%5>:7?=27:2A@-54/'93<:50;07=><85=:=::39<<<5='::9;<7?95;;:55/.,,9531'')93<73/4,24756#)1*15.1+-&,($*/.>?:96*;9+2,36>6;5?24=3($+).,991;9:A@;9<9=59>74<;5::397>:59;9/::>DC0:9D>>CD3<;@8ACA9;=@99;/5/25214;0)88,7/>8;6(6253::@,1::B;,.5/,,0:58<535/<;9;8;C>1?B791>.@<<91;658<9;745A:8>=A@??>>=;,1==:@;2.:8>=:1,0+0/-<;BA8)90859=9<@6&3;=8-/:7-56,/>78*267$3?:9=A<>>84:;<<-->7:37;=2B4+==3'.5<;:<8=:9@:??=<1><8,<735859;331<34:3/96;>95>>5<-A;/7?.>A@8<9<'7&1/@:?6?:/=856@937+,+)81+1+8*<20$5:?3<69AB==.76:><=45==77;766==,98:;:28?=>==86C<<=?=;7;@=>?,;>:9:A:@A<@@2;<96=AA<2<9>:4.8:-04>>@>?>1B<56;C??035/17826>?89=6/:=.+<=7+(7<=<=7<3;?A9*?4765(:;788<9<=784-7;47,.94>96:?$1(0003/-63?=<>37'64B>=CB:@726113:0/9=4:@603-:?1A:77*:>@=20=74>59;8396:CB66:>71>@?;;@;;4<><:C8>:&89697@9<7@1098%-4'6<3E;6;+?:@>?85;+72395<;*630<<6?:49989>73=<3698<3?9.:998<)9(*''(((/8785<55<99=7?=;83:7+3588;3;667867778(973+72:9;;7727'55=/3280(.*+31+4)4<77/364&988$38983,-4;=3348<2,)4-<523/6338;/16151%562,-/057.7:1/-/*3561<76<;(2,+,&1%-121020).:8126;:7756677:-42-6;>60<>>=?9687;=8*0/.56688984>-4/02-48580-(30-63;3;>98:9;93:8*4*,6990>9518;=?7<>93/891134 @rCer/1523/24_2833_CCS ATGGGGGAGCCCAGCGCAATCGGCGGCAGTGCGGCGGCGGCGCGTTGAGCCTCACCAGCACCGCCGCCCGCAGCCCGCGCCGGCTCAGCGCAGTTCCTCGCTCCGTGCCGCAGGTGCCTCCTCCTGGAAGGCGCAGCGGCGCGCGAGAGTCGCGGGCAGCCGCGCGATGGGGCCCCTCCGCGAGAGCAAGAAGAGCACAGAGTCCAGCATCATGACAAGGAGATTTCTCGAAGCCGAATTCCCCGGTGATTCTTCGGCCCATATGCCCCAACAACAGCACAAAGTGTCCCCAGCCTCTGAGTCTCCTTTCTCTGAGGAAGAGAGCAGAGAGTTCAACCCAGCAGCTCTGGGCGCTCAGCGAGGACGGTTAGCAGCAACAGCTTCTGCTCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCAGATGCTGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGACTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGAAGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGCAGTGAAGCGATTTTAGCTCCTCGAGCAGCACAGGCAGCATTTCCGCTCCTGAGGTCCAATGTCGACTGCGGGGAGCAAGCGGTCTTCTTCTCACGCAATCGAGGTCCTCATGGGCGGAGTAATGGAGCTCGTCACACAAGCCTGCAGCAGCCCATCATCCCACGGAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGCCCTGTCATATCCATCCCAGTTATGCACCTTCTTCCCAAAGCAGTAGCAATCAGGCTCCTACAAAGGAAGCGACTGTAGCCCATCATGAGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAATCCAGAGCAGTATTTTGACTCCTCTGCAGCAGAAAGAGGTTACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAGTGAAATCGTGGAGCTTAAGTCCCAGCTGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGCCACCGGGTAGAGGCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATTAAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAACATCCAAAACAAGAAGTTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGATTTTCCATGTGATTCCCAGAGAAGAGTTTAACCCTCAACCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTTGCTGGGGAAGGGGTTGACAGGGAGCTACTGGTGGGAGATAGCATAGCCGATGGCACAGATTTGTTTGATGAGATGGTAACAGCCACCACCACAGAATCTGGTGACCTGGAGCTTGTGCATTCCACCCCTGGGCTAATGTCCTGCAGCTGCTGCCCATGGTCATGGGTCTGGAGGAGGGCAGTGTGGTGGTGGAGCGAGCCGTACAGACCGACGTGGTGCCCTACAGCCCCGCCATCTCGGAGCTCATTCAGAATGTGCTGCAGAAGCTCCAGGACCCTGTCCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCTCTCTGCCTTAGTGGTTGATTTAACTCCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCGTCGCCAATGTGGATGCAGAAGTCCATGCAAACCGCCTCATGAGAGAGCTGGATTTGCAGCCTGCGTGGAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGCAGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGATCCTGTCTATAACATCGGGGCCTTGCTCAGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCATATCAAACCTAAATAGAAGTTGTTGTTACTGTGTGCCAATGTGTCCCATGTGGGTTGTGCAGGTAGAGAAACAGGAGGTCGATCTGTGACGGTTTCTATTCTGTCGTTTTGCTCCTCGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCATGGAGACCTGGTTCTAGTAAATGTCCCACCAGTGCGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTATCCTAGTGGTTCAGGAAGAGAAAATGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCTTGCTTTGCTTTGTGCCGTTTTAAAATGTGTAATCGTTCCAGCATTCCAATGGTCTTGTGTATAGCAGGGGACTGTAACCAAAATAAACATGTATTTGTGTAATTGGTTTGAGAAGTCTTGAATAGCTCTTTAGTGTCTTACTTGGGGTTGATAAGATTTGAGTGTCTGCAATTTTTTACTAAATGTAGCTACAAAGTCTTAAATGGCTTGTTTGTTCTTAACCTGTTAATTGATGAAACTGTGCATAAGTGTACAATGTACTAACTTATTTTGCTTATTATATATAGTGTTTTTGTTGGAAATTGTAACCACACACTTCAGCATGATGAAATAAAGATTAGTGTTT 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@rCer/1530/0_843_CCS CCATCTTTCCCCTTGAGGCTTCTGACCTTTGACCCCCTAGGCCCCCCATCTCTGACCCCTGGAGCCCCACTTTCCCTCCAAGCCTGACTTCCCTGCAACCGTAAGACTTGGCCCTGACCCTAACAATACCTTTGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCAACCCTGGCTCCCCTTTGACCCTTGAGCCCCAATTTATCTTTGACCCTCTTGAGCTCTTCCAACCTTGACATTCCCAGGAGGAGCCCCGCTTCACCCTTTCTGACTCTGGGAACGCGCCTTTAACTTTGCGGGTCCTCCTTCACCCCTGACCTCTGCTTCACCTTTGACCCCTGCCCCCCATGAATCCCATTTTACCTCTAGACCTAGAAGTTCTGGTTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCTCTGACCTTGCCTCACCTTTAACCCCATCACCTGAGCCCCAGCTCCTACCTCTGACCTCAACTTCTCTTTGACCTCTGAATCCCCTCTGACCCCAACTTCTCTTTCACCCCCATGAGTCCCATTTTACCTCTACACCTGTAAGTCCTGGTTTGCACTGGACCCCTCCCTCTGAGCTGCAGTTCACCTTTGAAACTTGCCTCACCTTCCACTCCCCACAGCCCCAGCTCCTACCTCTGACCCCTGCTTCTCCTGGCTCCCACAGGCCCCATATGCGTCCTCCCTGCCTCACTCCCCTCAGCCCCTGCCGACCTTAGCTTATCTGGGAGAGAAACAAGGCCCGGTTCCTGTGAGGAGGAGAGGTTGCCCCTGCCTCCCTTCCCGCATCCCTGCCTTGCCCTCAATAAATAAATTGATTGTTGTCC + 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CTCCTACTATTCATTGACGGCGCCTGTTTTGGCCTGTGATGTTTTATCCTTAAATGCGGTGTGAAGATTAATGGCACTGAACCGGTGCTTTTATTGTACAAGTCCTATAGTCGTGGGTGGTTCTGTGTGGTGCTCGTGTTGTGTGTTCTGTCCCCATCTAGGTCCTGGCTGGCCCGCATGACCACCCCCTCGCCTCCATTAACTGCGCAGGCACGTCTGGGCCCATCCTGGTCAACCCGCCCCAAACTGTCGACCTCGGGGCAGATAAAATGCCAAGTTCTCATTGTCTACCTCTGTTTGAATCCCTCCTTGTCAGGGGTCTCCTTCCTTTCCACGAATTGTTTACTGACTCAGTCGCTCTCCTGGTTTCCCTTTTTACTCTCTTCTACCCTTTTCCTTTTTTGGGCGGAGTACCTGTCCAAGACAGGGCTCATGTTTTGCACTTTATCTCAAATTTGAAGAGATTGCTGACGCCCGAGAGCCCGCGTTTCTTCATGCCTTCTTTCCTTGTCTCAGCAGGCTAGACACAGACAAACATGGTCTTGACTGTTTGTTGTCCACAAAGTCTTCAGGGTATTTCTTCCGCTTCCATTTTAGAAAGGAGCAACAGATAGATGTGTTGCTCTGTTCACCTGGGTGTCTGGGCTTCATGCTTCCTGCCAGCCTCACTTCCTTGCCCTTTCCTCCTGCCTTTCTCACACGTGTTCCATAGGAGGGGCCTCATTGTTGTCTTCGCCGCATGCTTCCTGCGAGCATTGAAGTATGGTTGTGATTCACCGTAGTTCTAGGTCCCCAGTCTGAGTGCTAGTGGCGAGAGTACCTGTGTGTTCATAACCCATGATTCCCCTTGATTAGCATGTTTGGATATTTTTTTTGGTGTGCCCTTCGTGCAGTGTGTGTGTGTACAATATACAGTGTATATTCCTTTTAAAGAATCTTTATCAACATGTTCTGGATTTGAGGCTTTAGCAGAGTAGCTGCAGCCTATATTATTGGTAGGTGCCGCTTACATGTTTTGTTAGTTTTAGCACTGGGGATTCAGTAGTGACAGCCACACTGGACCTCCGAGTGATTTCAGACAAGATCAGTGGAGCAGTGCCATCATCCTCCCCGCCACTTCTCCCGTTCGTGCCAATAACTTACAGTAGTAAGAATACCCAGGAAACGTGTGTACTGTCACTTGGCTGCTTTTTCTGCGCTTCGAGTAAACAAGTGTTGGCAACGAGACTTTCTCTGGCCCCTAGTGCCTACTGGAGATCAAGCGGATGGGCCTGTCCTTTCAATCTGATCCATCCATCTTCGTCTTTGCCTGAGGAGAATAGAGATCGGGCAGGCACGAGACAGAACTGGAGGCAGGTTCATCTAGGGAGAGTGGACGTGGAGGCCATACCTTGTGAAACCGTTCTGGACTGCAGGATTCAGGAGCCTTGTTAGATTTGGTGTGTATCGTTCTTGCGACAGGCTGGTTTGCAAATGTTTTGAATAAAGGCTGTATAAACTTTAAAAAAC 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@rCer/1536/1615_55_CCS ATGGGCAGTCAGCTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCTTCTTATGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAACTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGACCAGCAGCTATGGGCAGCCCCCGAGTGGGGGCTACGGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGCAGTGGTAGTGGAGGTGGAGGTAGCTATGGCCAAGATCAATCCTCCATGAGTGGTGGTGGTGGTGGCGGCGGCGGCGGTGGCGGCGGCAGCAGTGGTGGTGGTGGTGGTTATGGCAATCAAGACCAGAGTGGTGGAGGCGGCAGTGGCTACGGACAGCAGGACCGTGGAGGCCGTGGCAGGGGCGGCAGCAGTGGTGGCGGCGGCGGTGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGCGGAAGTGACCGTGGTGGCTTCAATAAATTTGGTGGCCCTCGGGACCAAGGATCACGTCATGACTCCGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAGACTGGCAAGCTGAAGGGAGAGGCAACGGTCTCTTTTGATGACCCACCTTCCGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGGGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGACCAGGTGGCTCTCACATGGGGGAAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGAGGGGACCGTGGAGGCTTCCGAGGGGCCGGGGTGGTGGGGACAGAGGCGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTTCCCAGATTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAAATGACCATTTTAG + IKKK8KKKIKKKKAKKKJKKKKKKKBKKKKKKHKKKKKKHKJIKKKKKKKKKKKGKDJKKKKKKKKKKGJKKCHKJKK,KKKKKKKKAKJKKKKKBKKJKJKKJKKKKKHKKIKKGKKKKIKKKKJKKKJKKKKKKKKKKKKKJKKKDJKKJKKKKAKKJKKEJ;HKKKKKKKKKKKDKJKKKKKKDKKIKFJKJKKKK:KJJJKJKKKKKKKKBCHIJJKGKIKHKJKBKHKKKCKKKKKFJKKIKJKKIKADKEHDKKKKKKJBKKEKKKJEKJKKKBAKHKKHHKFKKKHKGKKKKKDKKKKJ6KIJKKKKKHKKIKKIHKJKJKKK?KKKJIKJGKHKKKKHKKKKKJKK?AKJ=KKKKHKJKKKKKKKKBKKKKHKJKKKKKIHKKJKKJKKKKKKKJKKKKKJKKJKKKHKJKK@KKKKKHKKKK;KKK-KKJKEIKKKKFKKKKKKJKKKKKIKKKHKKCKJKJEKKAIJKK:IKEKIKKKKKKKJJK9KAGKDKGKKKKHKIKKKIKKK:KKJIJKAKKKCKKFBKKKKBK?KKKEKKKKKKKJIKJKKKKKKKKKKKKIKJKKKKKKKJCKKKKKJGKJKKKJJK5KKKKKIJFKKIKKGKKJKKIKIK2KKJKKKKKKKJKKKKJKKKKKKKKCKKK?KKKBKKIKKJKKKKKKKJKKKKKDKKIKKDKKKKDJJKJKJJKKKK$KKAKKJKKKKGKKKKKKKKKKHKKKK+KKKKKKKKJKKKCKKKKKJKIKKKJIJKKKKKHKKKKKKKKKKJKKGKKKJKKKKKIKKKKKKK.JIKKKKKKKKKKKJKKKKKKEKKJKKKKKCKD>CKJKKKKKKKKKKJKKKKKKCKKKKKDKIKKKIKKGKKKKKKKKKKKKJKKKKKKIKKKKKKKGKKKKKKKKDKKKKKKKKKIJKKKKKKKKKKJKKKKKKCGK @rCer/1537/25_1926_CCS ATGGGGCTCGCCGCCGCCAGCTCGCGCATCTTGTTCTTCTGCCGCTCAACTGTCTAGTCCTCCGCCGGTCGCAATGGAAGAAGAGATCGCCGCCCTCGTCATTGACAATGGCTCCGGCATGTGCAAAGCTGGCTTTGCTGGGGACGATGCACCCGAGCCGTGTTTCCCTCCATCGTCGGGCGCCCCCGACACCAGGGCGTGATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGTGACGAGGCCAGAGCAAGCGCGGCATCTTGACCCTGAGTACCCTATTGAGCATGGCATTGTCACCACTGGGACGACATGGAGAAAATCTGGCACCATACTTCTACAATGAGCTGCGCGTGGCCCCAGAGGAGCACCCGGTGCTGCTGACCGAGGCTCCTCTGAACCCTAAGGCCAACAGAGAGAAGATGACTCAGATTATGTTTGAGACCTTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGCGACGGGGTCACCCACACGGTGCCCATCTACGAGGGCTACGCCCTCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGTGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATTGTGCGCGACATCAAGGAGAAGCTGTGCTATGTCGCCCTGGACTTCGAGCAGGAGATGGCCACCGCCGCATCCTCCTCTTCCCTGGAGAAGAGCTACGAGCTGCCTGATGGCCAGGTCATCACCATCGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCTCTTTCCTGGGCATGGAATCTTGTGGCATCCATGAGACCACCTTCATTCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTATGCCAACACGGTGCTGTCTGGTGGCACCACCATGTACCCAGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTGGCACCCAGCACCATGAAGATCAAGATCATCGCACCCCCAGAGCGCAAGTACTCAGTGTGGATCGGTGGCTCCATCTTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGCCCCTCCATCGTCCATCGCAAATGCTTCTAAATGGACTGAGCAGATGCGTAGCATTTGCTGCATGGGTTAATTCAGAAGTATAAATTTGCCCTTGGCAAATGCATACACCTCATGCTAGCCTCACGAAACTGGAATAAGCCTTTGAAAAGAAATTGTCCTTGAAGCTTGTATCTGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACCGTGTATTCAAGTTAACTGTTCCCCTTGGTGTTTGTTTATACCCTGTACATATCTTTGAGTTCAACCTTTAGTACATGTGGCTTGGTCGTTTCGTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGGTGAGTCTGCATGGCCAGCAGTCTCCGATCTGTGCAGGGTATTCATGTGTCAGGGCTTGAGTGTTCTGGGATTTCTCTAGAGGCTGGCAAGGGCTCCTGAACCAGTTTCTGCCCTGCCAGTCTGTCAGGGTTGGAAAGTCCAAGCCATAGGACCCAGTTTTCTTAGCTGACGTTTTCTGCCAGAACACCGTGGGCTGTTACTTGCCTTGAGTTGGAAGCGGTTTGCATTTACACCTGTAAATGTATTCATCCTTTTAATTTATGTAAGGTTTTTTTGTACGCACCAATTCTTTAAAGAGATGACAACAAATTTTGGTTTTCTACTGTTATGTGAGAACATTAGGCCCCAGCAACACGTCATTGTGTAAGGAAAAATAAAAGTGCTGCCG + ?C0KHH%'0)'(HDBG8.@CD/IICB=@CHJKKCIG;GHII9JFJCIBKHDI@%%?AB1I'=IB7HFIEDIKAGIJKJFC,GGHJFJCHJKK-KK)H?CJJK;KJKHJEKGFJK8KKHAIKEJ'@7D:JKH?DKJGKI:=+))46JJC932.%7D:KH7KIDIGJ>GJE2JJIFJFIKJCBF7HHK'JDA(73KKE@@HGHKJKKG@G2EKK@HF?J47DA5KKBKCKF>JKJEKBKEG7@1,/KJKHK0K7JKC9IIKJK@JI>=CKJE2KIJIJHDJJKKBBJ>II7JJI7E2G>?@HJH*GJ?KI>9KE8J9CGK0IHF;H=KJ2KJ>FHKKJKKJJKEJE:JIKIK@KJHGKEIK@?#+GJJ7JKJAJG9JKKJAJKKAKJKJK?K1I?8IIEJIK>GFI=&GJKKKIIKKBJKHK>KJJKJ6K8K=GKJKI5JJKJCKEKGKJ8JJJHII8G.IAJ@E&E)JJ>HJ.KKJDD>JIJDJ4J)KKJK>KJJ;G5JG=KKHAKI9K7KKIKKKJK=JHKJHKJKKKAKH@KKKJFCJJBKKIKFKDKKJKKFKAKKJHKKKFJKAKJK?KKCKCKAKJGK;GHCKJIKIIH+KKKJGKIKKGI;KK(KKHE4IIIJI;C@KE:KK9JKKJK7KKKKJKKKKFKFFHJKKG0JEGKKJJK6KKKIH;BHJHGKJBK=IEHHHBKKK;KKKJG5KKKKCKJGK(K( @rCer/1541/25_2180_CCS ATGGGGAGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + KF'+%#,$##%)034?JFFKKKKGKJKJKKKJ?KKJKKKKKKIKKKKKKKKKKFJKKHKHKKKKIJKJKKKKKIKKK>KKHKIKKJKKKKKKKK@KKKKKKKKKFKCJGKKJKKJGGKJKKKJJKKKJKKKJKKKKKKK:KKKKIKKJKJK?KKKKKGKKKG;KKKIKKKKKKIKKJKJKKJKKJKKJKKDKKJKIDKKKFKIKKKKKKKJKKKKKKKDKKKKJKKJKKKKIKKKKJKHKJKDKKIIKKKKKKKKKKHIKKIKKKKKKKKKKKKCKKKJKKKKKKIKCHBKEKKKKJKJ?KKKIH3KGKHKJKKKKJJJKIKDKKGKKGKFJKKKIKKKKKKFKKKKKKKKJGKJEKKKKIKKKKGKKKGKKIKKKKKKIKIJIJKDKKKKKJJJKKKKKKKKK*KKKKKJKKGKKKKJKKBKKIK8KKKDKJKKKHJKKKKKKJKKKJKKJHKFIKKIJAKKKKKKKJJKKEKKKKKKKKJKIKKKKKJIKJKFKKKJKKGFKKKGKKIKIKBKBKKKKBKGKKBKKKKKGKKIJ@CJKJJKKKJKJKKKK8JKKKKEKKJKKKKKKHK@KKKKKKIKKJKKIKJKKKKKKJKJJHIKIJDKGFKKJKJKKJKKKKJKKKIK2KKKKBKK@KCKKKI=KKK;KKKKKGKHIKJKKKKKKIJJIKHFCEKKKKHBKKKKGKJKKKKKKKKKKKKKKKKDKJKKKKIKKKKKKHJKKKKKJKKKJHKFIKKKKK?KIKKKKJKKKJKKKKBKDKKKKHKKJJKKKK6KKKKGK?KKKKKKIKKJKKKKJKKKKHKKHJKKKJKKKKKKKKKKKKKKJKKFKKKEKKKJJKJ6KKKKIKC5KKKJKJGKKKKKKE>EKKKKKKJKKKKKKKKKKKKKJKKKJKFIKJKI;EDKKKIKIJKKKKKKJKKKKKJKKKKKKKKJKKKKKKKCKIHKKFKEJJI+KKKIKKKKKJ?J1IKJKKKKKKKKKGKKKJKKKKKKKKKKKKDJKIJKKKKKFBKKJKIKJFKIKKKJKKIKKGDKBKKKKKKKKKKK-KKKKKKKKKKKKJKKJKKKKKKKKIIIIJKKI;KKKKIKJKDKKK9KKKKFKKFKKKKKFHKKKJKKKKJFKJKCKGDKKAKKKJIJKKKKKKKKKKAKKKKKKGKKKIGKAJJKGKKJK7KKKKKKCK3KKKK?KKKKJKKKJKKIKKKIJJKKJKKKKKKKKKKDK:;KKKKKIKDDKKBKCJKGKAGBGBE2.AJIKJKGKKKIKK4KJKKKKK>IKKJKJ@KKD=K1KKKKKKKKKIKKKKKKKKKJKKKKKKKKKJKKKKJBKKKKKCKKKBKKKKJKKKKKKKKKGKKIKKKKKHKKJJKKKKKCKKKJKKKKKKK=KKKJKKH6KKKKJKJHKKKKKKKKJKKKKKJFKKKKJKHKHKJKKKJKKIKKKHKIKIKKJKGKKKKHKKKKHKKJKKKKKJJKIKKKIKKIKKKKIJKJKKIKKKK9KKJKKKKHHKKKIKKKKKFKKIKG;KJIEKKKGIKFJKKKKKK @rCer/1542/26_1663_CCS ATGGGAGTTGCGTTACTTACCTCGACTCTTAGCTTGTCGGGGGACGGTAACCGGGACCCGGTGTTTTGCTCCTTCCGCCTTCGCTCTAATCCCTAACCACTATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTTGGTGTCCAGATTGGCATGCCTGCTGGGAGGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAAGACCATTGGGGAGGAGTGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCCGGGCCGTGTTTGTAGACTTGGAAAACCCACGGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGTACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAAGTTGGATTATGGCAAGAAGTCCAAGCTGGGAGTTCTCCATTTACCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACTCGTATTGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATACGCCCCTGTCATCTCTGCTGAGAAAAAGCCTACCATGAACAGCTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCCTCGCCATGGTAAAATAACATGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTTCAGAGAGCTGTGTGCATGCTGAAGCAACACCACAGCCATTGCGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACTTGATGTATGCCAAGCGTGCCTTGTTCACTGGTATGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTTGCCCTTGAGAAGGATTATGAGGAGGTTTGGTGTGGATTCTGTTGAAGGAGAGGTGAGGAAGAAGGAGAGGAATACTAAATTATCCATTCCTTTTGGCACTGCAGCATGTCATTGCTCCCAGGATTTCAGCTTTCAGCTTAGCTGAACAGACATTAAAAGCTTTCTGGTTAGATTGTTTTCACTTGGTGATCATGTCTTTTTCCATGTGTACCTATAATATTTTTCCATCGTGTCTCAAAGTAAAGTCATTAAC + '+&,)&))+,0,&&%#$*+$(-)++*+(*)%*-#&%('%,/-'&.,/.(.%&$-,-,22/2.)&$#)/*)*-+.),+),*-(-%+$,,2-#00)--),.)/(%&%(($&&)-)(,*/-/+#%-,,.-202-2,+2*$($&'%%+1-+*/0&-+$(**+-,/*$-+)(/**,+/,&*%),,2$))+,*0*&-,,+%%,,(#,32.00*'*1'.+1,-+01'.-$&'21-0&2--,,-))$0'&*+1(00%-'&).*2&$1100*//.,-(45.0*'/22)'(,-00/+&.(+1664111&(.20.)+,*/1,4%*,.+,(&.$-'#,(54.1+.53'5011.*.&2+/,4+1263+.*.,*+'1./+-,&$,),'%&%))$0.++/*23.-.)-.'&*(-13-+((')/,0*%.'3,(*).3/(,(,(')/-%,,2.)4-5--+/30244+04,42./*006.(0-(1*12*.-,()*(/(&'+(2.**--1/2.5-.,330+/4/*230356*410-221*25/6414.$.0.*'/,0'//4-''2.(0.0111%-)'$,/113+42.))($,)13$-015%)&$/0//3206.,303+1'2/.*$,'+//522.23(540$-'(-/-2442(2+00)1.0304+0155&1)1..24+./134015-&--...(/,**%+'/+./*.-%-11%1(,(-/-')0$0-,/-1.+-'11+*))&0*+(%4-410/*1+0*)(($$-0,/-.0(3+%-/1&7.63-15.366)5,/10-/22-76407.4282)2/6,.653+363.,5/'*/'/,%)+//2100-22-5533.,.%20/.1#5./(1$(0-4','.1501/+1454.5)02303/)21.,2)&/+2(221+#-120-)(.*41)&.&0+(//23'52.012./,54.,1&',/0200/--/.,$,0223&0,026/(1-112-/%0-.3.1(1+1/304.+#,-)),2,30.%342/4(*'324-3+3312'-4/''53,4)$,$/+,/10*14.,5.'2---$-130$+&32,(/3622(4-)*,.++),+'1)),)1+2+24'213432$044*11$0-2,+5.,1$,3.-306.'.3/3,(+0.4142153'&,///-.046.42,-130)+3260&)302+123%-%/11634+,101*4'%1234023,/%&,3.03.26+)-14/*0.41604%22.02*/,,%+(1.&*00%0),/&-*2*23.*,/%()(41(0/&2('/*-+&)./1)-)-,&0)+2-0*2')..-/'.201+0/(+(*.$2***'()0%2-.-342(22((--.)10+,0,365,+/4,+3+.*+'-()+50413.5.5*03/0/)0-241/04('.(*32/62(+&126.120'*4$,3&.$.,)3/'.)-.(234-,42/0,0/)+%4,/0-3%4%(0$,*'*,-'2*+40+4-.1*-,4-.1-.%02-,000-+./#&(*+),.0&130/(331-32(1//541'0.1/).2653(,/&+-/./0)$,$/2123,21,0+614513-51%)00%)0010425-+.-$002'3032.2$10*2.0&--'*/22+(542*$1-0-1/0.*15(12'.2563,,1&6).. @rCer/1546/1621_57_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTGT + FGFHF&I?@?CEHABF?F=B@F:E>FA?0:A6:<<=A54ABAH@EHB@F>HFGCDIEE>>3BFFA98;2?DC:@JD;CH?BJ/FJ6CHDH)ECHE@7D7JGDDGEI9HAGJHAGA?C>IHKJF4DA;BE?KKCFBICGHI>HKHGJ?FCH>I-CBKCDJIH@?2:I=FI=JBB>I-FIJ7ECDC.-C2?9:>FDGKKJH+CBGEHEDH3?BIKJBFGI7FJE6>DKJKCIHIH0HGIFII9EBCHIF2BE=JAFF<=A5JD3JFB-FBCFBFGJHH<<87K=JGJGEH7E?IJKIHGJ=JKEEJJG9JIKJHI7BF8EIICC>IHHJJAFH=GEH8JJH2<4<;1EGFG-EDD;FH>B@?9;I7E;EH>D;=@?:0?>?B:;=69378=.?C;,?@CD@DE6=D;;>A6GA<36?B;EAA=CD:9=?CH4DE@AA9A:<5,2CA9FDF?BF7EEGA?BADCG9952>;CEBICBC?AB<@@<8@6D<:<@;>:CA46418=C>G@GE:G;@=>@A?A?,@@CCB&:7>/G?FH94FF?EKEHH?GG*>KF=;;E:IIJIFCI/IHHGDF2DFDGEI?HGKJJBIDBFDIKGJDFAI@4GF@>HH4ICIFG@BACBGGD;JCDHE=GGADC>DH+JG@II?KIEHKG:FE2CA=.FCCIH>JHKJFF>>KFDFAKKEDK@CJ7KHEHH@?A0E9FKG3FKJHKDGFHKIEJBDGKIAFJJJIBIJJIFI2AJ?FC9JD/JIGKGIEJHHDEBCHIEGFE$6GI;KBIEJHJ9HDFD>DHIF>3AIGKDCGHI1HA?E5IJBID;3>FADJEIJHE0HBEFCKIFIFIHIHIEJGFGJK1FFEGBBIKI;;FDJKDIIHI>DC09>GIHIGC=G5HKFGJ=JHI@@GIB;GEJ9HIIGEAD9F?HHGC3GJCFJ@HIDICA6GJGGICHIIHHEIFBFICC4=DIIABI@BDJGJHK2FDGGI:HKJ?KDCFCFFD@DIIEKIJEJD@KDIIHHGEIGGF;C=BKCJE=IKJEH?=DDFIKACDDCJHB@ACAGFIHFCDC-BFJD>BIHKFB7D7DH9JEKKIF4DFJAC@ECDKBG=CCI3JJFF+EIKKBICHHA @rCer/1547/670_69_CCS CTGTGGACCAGCCTGGCCATCGGTCTGGAAGGAAGGCACACAGCACCATTTCGCTAAGTCCGTGCTGGTCACGCTGTTCACCAGCTGGCACTACCTGCTTGATTCCTGCAGCCTACCTAATGTGCCTCCCAGAGGTTTTCCAAGGTGTCTTATTATGGGAGCTCATGCACTCTTGGCCAACGCTGTCTGGTGACTGATCAGGGTGAGGGACTTCACTGTGTAGCCCTTGTGGTCCGAGCGCACTAACTGGTACCAGTGCTGTTTGCTGGTGAAACTTGACAAGTTCTGTTGAGCTGTGTGAACAGACTGATGCCTTTGTCTCTAATGAGCTAGATTGACCTGATGATCTGCAGTGTTAAAACGGGCGAGAAACCATTGCGCATGGTAACTGGCAGAACCACGCGTCCCTACGCGGTTGTTTTGAATCTCAGTCTATGACTGTGACTCCCCCAGGCTTGTGGATTCTAGGCTGCATCACAGAGCTGGGGCTTGATCCCTCTGCCAGTTCTTGTACCTGCTGTTCTGACGAGTCAAGACGCAGTGACCATGTTGAGGGGTGAAAACACAGGGTTAATTAAATTGCCATCAGTCCCTACCATTC + #",,'+$-#..*,'.+*-,#..*&-&/*.,.*/-/&././."/.,"-).'$)$-&."*.+,,//.+/+""%#"#)..).##-..%-""&%....../.#*,,/*,///../,.."+,..-/--.'#.+)+,.&.*&'(,+)*-*)..#)#,,.$",,$'+.&,.-...&)/-/*/+*+(,+.#$+,,''"..+"..#/&).*)-#.-*&.-&#-.##.-#*+&(+*+"*%+%+,"+&%%"#-#&(%#%"*-+,)+//...,&$$-,.."..*(+)",#..-./.*--.&*.&..".)...""..//////$',..&+/.-.-.)+(..&-'-+%#,..,.-/.-.#/..'-(.*.",')#+&'$##',--(-,$%#*...-./.+./--/++.&/*'.)...,..-*+-.+.##*)$",'#&..,)..#.--.&#**+$...'/,-,*))+-.)-&',..+-&).&-.*$..#$.-,./,///-.**)'($/./+,+*#-/*#&..'#(#&&)-*--"%%&*&##-,&)..,-#."#-...*..(+/#&-#-/,(($#..),--,(-.+),%*-/#,*)/()($(.#...+,,.+-)".*( @rCer/1548/26_1629_CCS ATGTAGTGCTCATTAAATCGCTGACTCTTTTCAACAAAATCACAAAGACATTGGAACCCTGTATTTTACTGTTGGTGGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCGGCAGCCTACTAGGCAACGACACACTATAACGTTATTGTAACGGCCCATGCATTTGTTTATAATTTCTTTACAGTTATACCCATCATAATTGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCGTCTAAATTAATATGAGCTTCTGACTCCTCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCGTTGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCGAAGTCTACATCCTGATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCGACGGCTACTCCGATTATCCCGATGCCTACACCACATGAAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAACGTAAGTACTACTAGTTGAACAACCCCTTACTAACCTTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACCATTAAACTAATGGAAAAAGAGGAGTCGAACCCCCTAAAACTGTTTCAAGCCAGTCTCATAGCCCTATAACTTT + ""#""!"!"#"#%%"$"#$%%%%%$#$#$$!"$"#"#""#"*+''-,-,((,'*,-**-''',''&+---*#(%-*#&(&(,-,()+*,-',*)',-+)---%*)('-,('(,-'%#&),'+))-,()()-,-+(%(#+*.--*$$*)-*)&,)(*-++$((*#+)(('++*-)))*(+.,*+$+,+*,,-(-+(%+)(,,*#)&%)--'*-)#(&%$%*)+)),%%,&-%+(')&%),-.00,..,'')+',&,-.-),,(*//%./.-0.01-,+/.,0000/1'//-*)-'+-$++0*//,/+&--+00,0-/.(%*)&%$*(((&++0.01-.,'/(100-01.1,0,)"',/+--+1*,%$,*1.2,,1112101101*1/1..-&+,)/)(,+0,/+2&*-,.20&+2.*+.0/&'+(**/'//)(,0-.0.1..111120*00,,0*+12-00&&%*,+'+/$)'*.%.,--+((+01200..2*+0-.(.)*,/-0/1-'/,$,/,1)11.),-*//,0-..10000*00'-2*,*,1/./220%.'&)',011100*0021.)+--*/-22.222+.2.--&4)//-%.*'/2+0+)./*0+2',,()-(*,0,01(---,0+(+.0%*+/+-,2/0,*/,-/-/*.021/'++*&$0/.-0&000+.,,)*-/21+/,.-*,,00-.*+*0-0).0,,10+,0/11-*$+&-0/(.+*/1/0*-*-'#(/1+)*'-+)1/,2/(*)2.,.+0..0)0100.../1,)0'.*-+*,-*2.2).2220',+-+(*.%.)(+,-1+00,0,.0&-'&))/2.+%-.111/0(,+0-)//.-,)(,.1*&%,11,-1--#(')*-+*--/+/+100(-112.&.11.*0*.)*/+(--,0'&+./1+.--1-21.0'0+.+++/./+0+0/.%+(#.-(+-*-(1.1122,',+-/.11-1211011+*,/.12+--02/&+).,,%#+,1.00)0%+/.01/,-.0+%-/.*--..00*0/%/++.,.2121-.-0-010,1)/&-21./-//2+0*/1--/-)./21.21,&*,))1,-11/(+1+,%*/1111/,-,.10+00*(%-')/-0/,)2/)#,.//*0010(./0.',+011-.-0+-+.1/210--.+21./&,-0.+//,-/+,-11,0,02.2).+(-/,/.-,.-00//*..00'1(-&11*(/0).*0)+-'+-1-1/2,/.-0,11+**//1+++0111122/-./0/(0---01/.--0101')1+-'(%+,))(&))*+*/)+$)''&%#()*)'(%.%)%,+))-*'*&+',%**..20/*++$*,(0-..-/-110,0,1.11.-,/1+0,)''$&*(&$%*-+/,,/+0),-++,&',+&)+-)+--**-,(+)&(#*&)-,(+.-&++))*#)$)'+,)+(,)+.,+-%(*'-())-+---.,.%*+-,&()*)+(,+,))'('%%'*++*$)'('''',+),$'()(,,)+$&*,()&)"#&$%%,,&$$!"%%$%))&"#"%#$#$%%%#$$%%$"%%%%#"#%%%%%$$%%%%$#$$"#$"%%$%$$$$"$% @rCer/1552/22_2333_CCS ATGGGAGACGCGGAGGGCTGCGTGCAGTGGGAGCCGGCTCAGGAGCCCGAGCCTCCAGCCGTCCCCAGAGGAAGGCAGCACCGGGCCTGGCCACAGCAATATCATCTGAGGCTCTTCCCTTCACTCCCAACCTGAGGTTGCCTAACTCTTTATAAAATTCAGAAGGGGAATGCCAGCCCTAGCATGGACTGTGATGTTTCACCTGGTGCCTGTGTGGTGTCGAGGTCTTACCAATCAGGAGGTAAGGAAAATTTGAGGGACTGTTCCGGACTTATGACGACTGTGTGACGTTCCAGCTATTTAAGAGTTTCAGACGTGTCCGATAACTTCAGCAATCCTAAATCTGCAGCCCGAGCAGGATAGAGCTTCATGAAACCCATTCAGAGGGAAAAAATTAAAGCTCTACTTTGCACAGGTTCAGATCCAGAGACAGATGGAGACAACTGCACTTGGCTCCACCAGCCTGCCAAACAGTTCTCATCTCGCCCCTTCCTCCCCACCTGTTGGCTGGCAGCCCATCAACGATGCCACACCAGTCCTCAACTACGACCTCCTCTATGCTGTGGCCAAACTAGGACCAGGAGAGAGTATGAGCTCCATGCAGGGATGAGTCACCCCAAGTGTCGTCGTCCACGTGGTGCGACAGTGACATAGAGGAAGAAGAGGACCAAAGACTTCCCAAAGCCAAAATCATCCAAACTCGGCGCCCTGGCTGCCGCCCTCCGTGTCCAACTGAGCGCCTGCTCCGCCTCGACGATAATAGCCGTCTCCTCTTTATCATGCTTTTCCCCGTTGTTTTCAAAAAAAAAATGCCTTTAAATTCCTGGTGTTTGGTGTTTGAGATTCCTTCCTTGTATCAAGCCTCTCGGACAAAGGCTAGAAAAGGTGATAGTCTCCTGATCATATCATACCCATTAAGTAAACCCATTATTTAGAAGTTCTAGGGAAAAAGTAGTATTTTCTTATTAAACAATCAGCACAGCCTATATCTTGTTCTCTCATGTTGATCCAAGCCAGAGACATCAGTAACAAATAGCACCTGTGTTGTTTGTGAGCTGTTCATCCCAGTCCTGACGTGTGTGCATTGTTCTTCCTGGCCACTTAAATAGGACCATATGTAAACTGACTTTGACTGCATGAGATATCCCTGTCTGGTCTCACTCAGTCCTCTGCATCCCGACATTCCAGACATGCATGATCACCAGCATTTATTTTCATGATTTGAGGAATCCTAAACCACAGATTGTCGCATCCAGCCATGTCTATCTAGATTAGGAAAATGATCAGCATATTCCAGCTCACAAGTCTGGGTATATTCACTATGTGAGTCGATACACCATAGCTCTGTTGAAATTCCTGGAGGCAAAATTGAGCTTGGCCCCAAAGATATCCTCAATAGATTTCAAACACCACTCCCCTGTGAACTTTCCAGCCTCGTTTGGGGAGGCTTGTCCAGGGTGATAGGATCGATTCAGACAAACCTATTATTACAAAGTTCATGGTGTCTGAATGATGTTTTCTCTCTTGTATATTGTACAAATGTTCAGCTGTCTTTTAAATCTGGATGTTTTTATTAGTGATTGTTCAACCATAGCTGCTTCAAAACATAATGTGCATTGCTAGAATGCCTTCATATACTATACAGATACCTGATATTACGCTCTAGTAAGGATCATGCTGATTTTGAAAGGACACAAACATCTAATGCCAATATTACATGATTAGCTAACATCTTTGCTATCAAGACACTGTTTTTAAATAAAGATGCAGTGTCGTTGTAGATTATGGGATGAAGCTAAATCTCCAGAATGCAGCAGCAGCTGAGCAGTTAAAATGGGGAAGGATATAGATACATGTATGCTGGTCCTACTCACGCAATGCCCATGTGCTCAAAAAGTTATTTGTTTTTGTTATGTGTGATTTTCTATTTCTCTAGCCAAAGTGCATTACAGAAGATACACCTATAGAACATTACCTTCTGCTTATGTGCCAGGCCTCATCTACTCCTGTACATTAATGAATTACTTAGATGCAAATGCAGATTACAATGAGTGGGGAAGTACTTTCATTACCCAAGCCTCAGAAAAACAGAACACACACAGCAAACAGCTTGAGGATGTGTGGTTTGACTAAGGTGTATGTTAGTTCCATCAGAACTTAAAACTAAGACTGATCACTCAGAAATAAAGTCCGTTTACTGTGAATATAGCAATATAGACGGACACAGTACAGATGAAACGAGGAGAGCATTGCTTGAAAATCCTGAGTTCCATAAGAAAATGAAAACTCCTTTAAAAATAAAATCGAGGAG + $(&))(&((((%((())(%()))(-(+),.-&+&#%+'+#($'(#&,-,(,)--),),,*,(',,*$)&)-,*)-+'(,,')#**%,(*.',+,,&#$''(%#*)*&#*,-),*()&,+&++,'+%+,(,*#&)'')+-+,.,+**'$&#&&"#&),',,),),%),,()(--.,)'-,(+(-+(+.+$"###('(#*&&+%#+*'$)%)(),+)&%%#$*,*)*&&#,&+.,-$,'%',)(#)-()',.-&+,(+%,**---+-'+,-)(++&,(+),-*,+*+-,%&),-+.),)&,%&%('&''#)*'*))$%)(),.*#%$'()+&',&'+,,-'))+)%'',))$)+,),)#&)))#/-*)&,),,*',*&+(&%&*#)%&,-&+,*,00/,10.0+/11-)/-0-*1012-//+,*&))-./1/-010*'''&$($,.,/,-1/2%,&*+/,%/())--/)0)+01,3&.+"-1.2)(1,+/402&*/,465253/4,1112,0+340*,4664+2153**+/*#&/1/50)-23-42*065*030524//.-'-)/0/226./0/15*4/364(+,03.*..+)3/24,/5.(+4/+/4,#&%%,$')0/214401.112/2)12012',0554(.,'-)0..'#$-/('%2/1544+*,$1&2.0'./6.05$-.,'+(1,3/24.-4*11/+31214*54021$.1*53-0/405413)$.26)///3&#/00510/650-2-54022/)5/*5120*')',()#--4231011'10-$343,*-/'*&#-&/320+--,&$0'2&0/).30,-1.$.-1'++)(#$'&3-&%'(,161134$)$$'-3/500650152/2.$1.#/***$$*01-2,-**%%'03,3-01+1(.+-,-,2162-&1*11)$01/552*42043.10+*(12*,)*.)+''/2,.&..)0-,.+01'1(221(,0441-410/,4.0+0.2(2(.31649:6-.&.6,+*2/2(3440)0044.7356239)324443737++./)1,+8851283.$*$150#,581518;43./244,4(35/133(-)'4)11.5021*$,.1555.01*/-&*3*2(15,$-10065010-11+.'+.*'*)&(,.%.0+.2-/'.-0+/%+*),'&,11..(.,(#$*%%%/,&.1.+0--12*25//2)/0/%(-,$//,.0,35*1110,3%$$$""%#)2$520..0335+#..+102),/110/%$)//4311.64//+352,(.-/1*0.*114.114/3$#**2.)-*.61/.00(.//2.1$/22&02,554-+($-'--54/0.0)13'0//6*+./41040%22,,652-,/3+(#*0)#--+,-+$+2'+*030/2)340/3/+,'+13/#*+.-+%#*3$%-(&1//'4/1.(+1$-),*&*.*123(4.)/43./.,*$/0562$-15*2/(2*/61.$01,413$43,)0/23%2)*(/24&0')0$,&((*.('&%(.0.-%((0.113'3302-40-+0,-&#$.-'+424)(-501&$133/-%4//..1'3./63+0)2-$,).,0*022%21/0,103,1/*,.'05*$%$)3)4/6+2.0,-*,31$),)&.*0(-$-,+/%,(10+301104302-.,-,+).-)2$%,240'11.3+++.#(1001//*040+*#)%)#")1/,/3%,/*/0'0/').$&$)010/5*.'%#22$.+5651'3/)'/.-1302#+0.+$*)0&'21.)(($.36504+5+02*222455311-4'.3*-4+232220/+///$*()../.&34103(/.+*,-.15520.0+0..-0**146(,0/-/+/.)3/)(/10/+//2/4-/0300-20'121%+0012+55((-1)2,&.+,)-+#)&&$+,+/%1+,1/$'*)&*)+(--10+'*/(,2,,%(,%*$-'.0.,&+)().)%+'-,+-2,&/.2,&-1/-.),()*,0.11,/(+---+).')#.,&+%(1)+*'',)&&')*)((($%),%)''&((*')%$$(,()*+-+&*)(-,-+&$,+)*'#&%*)$##)(,'++)--*(-,&'$&$)$#&$'''(#+-&()+(,,-*,))&&"#*'$)$*+&++((+)&')-++(##&),*))-,',(&(+&#&"$"$*,-,-*#&&'*'&++)-&&''(,')%$&(#$%"(*),-**'-,+)($#(-,'$+&+&%)')-+(,''*%$(**)),&(+%%&)+,+%#"$&+,*'$(**&$#%&-)#(()''&)'(*($(%((' @rCer/1553/2133_58_CCS ATGGGGGCTGAGGGGTGGTGGAGCGGTTGGGAAAGTGTCGGTTTATTTTCGCGCTCCTTGCGTTCTCGCCACAGCTTGCCTGGGCAGGTAAAGCGCGATTGCGAGAACTCGGCAACGCTGCTGACTCGGCTAGAACCGGCTCCCGGCCCGAGTCCGAGGGGCGTGGTATCCCGGTGCTCCGATTCCCTTCCGCAGGCTCCTTGGGACCCGCGGTTCTGGGAGTCCCTTGCACAGGGTCCCTTTCCTGCAGTGAGGCTCCGTCCGGCTTCCCAGTGTCCCCGCAGACCCTCATCATGGGCAACACGAGCAGTGAGCGCGCCGCGCTGGAGCGGCATGGTGGCCATAAGACGCCCCGGAGGGACAGCTCGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGCCCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCGGAGAAGGAGGAATTCCTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCCCCCGCCCAGGCTCGGCCAACTGTGTTTCGGTGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCTTTCAACAACTGGAGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAAGGAGAGCATCAGTACAAGTTCTTTGTGGATGGCCAGTGGACCCACGACCCTTCCGAGTGCTACAGACTGCAGCTTGTGGTGGCCAGTTAGTCGGCAAGTCGTCAGAGGGTCTCGATTCGGCAGGAGCTATGGGATGGTGTTAATACATTGGCAGAGCAACCCAAGGGGGCAGCACATGCAGTAAACCGCCATGCAGAACTCCCGACGGGCCTCTTCCCCATCCCACAGTGGGGAACAACACACTGTCACAGACAGGAGATCGAGATGAGGAGTTGGCTTTTCTGGCTGAGATTTATACTGAAGACTGGTCCCAGACCTAGGAATGAAATAAGGAGGAGGAGTGTTAGCCATCCGAGGCCAGAAGTTGCTGTGCTCACCTTGCACAATGCAAATGGGAATCTGCAGCCCCTTCAGCAGTTAGCAGTGAGTACTCAGCAGGGTACTCAGCAGGGCAGCACCCGCTCCAGAGCCTGGGAAGCCAGGGAGTGAAACTCACTGGAAAATCCGAAAGCCGTGTGTGTACCTGTGTTGCTGTAAGCATGTTAACGCACACACACGCACATACACAGTTTCACCGGTCAACTGGGAGGGATAAGAAGCCACATGGATGGTGTTTCCTTCTTTCTTTACCAGCAGGTGAACTGCACGTGGCATCAGAAGGAGAATGCCACCCAGAAAATCAGCCCCAAATGGCAGAAAGGTGGCTCCTTGGCCTGCTTAGCCTGCTGAGGAGGCACCAAGCACTTGAGCCATCCCCTGCCTGGGGGAGCCCCTGGTCTTCAACACCTATCCCTCTCCTCGATCGCGAACCTAAAAATTACACAGATCATTCATGCCCATGATTTAAACATTTATAAAAGTTCAAAGTTCTTCTGGAAGGCAACCACTGTGAACACTTTTCTGTGTAGCCTTCCAGAAAAACAATTTATATATACACATGAGTGGGCCGAGCGTGGTGACTCATGCCTGTGGTCCAGCATTTTGGGAGGCCGAGGTGCGAGGACTGCTTGAGCTTAGGAGTTCGAGACCAGCCTGGGCACACGGCGACATTCTGTCTCTAAAAAAAATAAAAAGGGGGGTGGGGGTGGGAATTAGACAGATGGTGGCTTAAGCCTGTGGTCCCAGCTATTCGAGAGGCTGAGGCTGGAGGATCGCTTGAGCCCAGGAGTTCAACGCCATGGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGGGCAACACAGTAAGACCGTGTCTCTAAAACAACCAAAACAAAACAAACAAAAAGTGGGGGAAAAAGCCAGACATGGTAGCTACAGCCCATATTCCCAACTACTCGGGAGGCTGAGGTGAGAGGATCGCTTGAGCCCGGGAGTTCGAGGCTGCCGTGAGCTATAGTCGCGCCACTGCGCTCCAGCCTGGGTAGCAGAGCGGGATGCTCTC + BHHFFF.4=GFD><&:I4BDCCBHE:IFCI@FD;,A=ECIGF:FEBBIG@@IEG8E?7GEH@FC@@FGEEJGFEEIF9GDIGHBJGFJEJI;HCIIJDKEGJK7IJ@HB@?4FJ=DC=JJIKDJJKJKKGKIKCKFKKFHHJHKGIK:BFK+KKHCKAKGGI)KKHKK,KCKJKKIKKIKKKBGJ1;&EKJIKIFHH6JGKJKKKGKGKKDKKGIIJJJKKK6KDKJKFK4KKKEI>IEK=HJG=BKJKKKJBIKIIKJJJHHIIFHJHDCKKK?J:EKBKKEKIFJKHJKKDFHA1KEJJJ.KBDKICIKKJK0IKKHKHKDFIHJI5FK?I@KK6CAI;FKEJI>IKEJKKIIEA,H-I@C9KJGKEIHJF8IJHF,I9JF+KKKJKJKHII8JKAGIHJKIDKFFB>BKIAKJJKIFFKDK7HKIFEJKIKHJJFKKEIGGHJ1IJKHJIKIGKIFKIJGKIKKJJC>JDIJ@FIIBKJJJIDJII@KIE6IFE:KD@JJJEEJJKI8J8JDJIHJK:HKKKFCIFGIJJ:CEHI3BK;8JJBKIKJAGK;JG@JIGK8KKIKJHJIJK?GJK=G&EKGEKK>JKIJKKCJJKCIJJ*AIJ;GJH=IK8GC=GJEGGGII:KICKHJKH7JJKIKFKJIHIK@KBIKCF=D>:IIJIJKGHFJJKKKKKK=KJJAI7JKKB9JKJ6GKKEKGKC>JAKKCJGJJKKKCK@EJKK@JCKDJKK1FJK2IKCHKJDKIJKKHKIKJBKKCKGJIDIFJIKK2KJGK9KJG8K>IAI:GIHBCIJGBIGEAFCKJJKGHKKHKGFHGIKGKHKHAHJKGK6FIJAJIH>D%D@IHI2GKHIIJCJI3CJKGKJKKJ23AHBBJGIFKJIIKJ2JCHIKJK0KGKK@DBIFKJIKFIKIJJF&EJKGKJ5JD?I=CH5H9BKK:JI?KJJ2HJG>K?BJJFGCJFKKGKDJKHKJKK8IHCIKK@HFG3DDFHKDKIFI9FJHHJ:JJ9JC:GFEH?EHKGGE=JHCIJK=J5EKHKK6IIIAJJJJIJFJDEKIKIJK%@GIGKKK?<9%GFAJJH@KIKJKKJKIKKGHKCICKEGI54JKKJK?KJJKK0HKG;EKCK<3CDF6GFFIE,DIH:FG*KKKK5EKHKJJFKJKIJCKIJJKKIKI9FI>I,KH7KIJKKD:KJF-JJIJGID*KK2JKKCJKJK=KIKKAKHKGE5@HKHGJKJKIE.HFCKKHEEKHKIK>IHJ1DJHGJJKJJKG/@IJEIGIC @rCer/1554/1351_57_CCS GGGTGGACAAAGCCCAGCGCTATGCCGACTTCACTCTTCTCTCCATCCCGTATCCAGGCTGTGAATTTTTCAAGAATATAAAGATCGGGATTACATGGCAGAAGGCTCATATTTAACTGGAAGCAGGACTACGTTGATGCCCCACTGACATCCTGACTTCCTGACTCACTCTCTGAACATTGACTGGAGCCAGTATCAGTGTTGGGACCTGGTGCAACAAACACAAACTACCTGAAGCTGCTGCTTTCCTTAGTTAACAGCGATGATGAGCGGGCTGCTGGTACACTGTATCTCAGGCTGGGATCGGACCCCCCTTTCATCTCCCTCCTGCCCTTTCCTATGGGCTGATGGGCTCATCCACACGTCCCTGAAGCCGCTGAGATCCTCTACTCACTGTGGCCTATGACTGGTTTTCTTTGGGCACATGTTGGTAGATCGGCTTAGCAAAGGGGAGGAGATTTTCTTCTTCTGCTTCAATTTTTTGAAGCATATTACTCCGAGGAGTTCTCTGCTCTGAAGCCCAGAGAGGAAGAGTTTGCCAGCCCGGATGGAGGCTTCACCCTGGAAGACATCTGCATGCTGAGACGAAAGGACCGTGGCAGCACCACCAGCCTTGGCAGTGACTTCTCCTGGTCATGGAGAATTCCCCAGGAGCCACTGGGAGCTTCACCTATGAGGCCGTGGAGTTGGTCCCAGCAGGAGCGCGACTCAGGCGCTTGGCTTGCAGCCCTGAGTGATCGAGAGACCGGCTGCAGGAGGTGCGCTCAGCCTTCTTGGCTGCGTACAGCAGCACGGTGGGGCTTCGGGCAGTAGCCCCCAGTCCCTCTGGTGCCATCGGGGCCTGCTGGAGCAGTTTGCCCGTGGTGTCGGACTCCGGGCATCAGCAGCAATGCCTTGTGAAGAAGCCAGCCCTGACAGTTTCCTGCTCCTCTCTCAGCTGAGCCTTAGCAGAATCAAGCCATGCTGGCCAAGAGGTTATCAGGTCAGGGGAAATTTCACTCCCATCTCCATCATGTACATGGCAGCCCCAAGCTGAGCAAGGCCAAAGACAGGGTTTTCCATCCCAGCCTCTTGACTGGTGACCACCACCCTTCTGTCACTGTCTCCCACCCACCCCGTCTTTGCTGGGATCCCATCACTCTCAGAACTGTGTGGGGTTCCCTGGGGCCTTGTGGAAGCCATGACTTCACAAAGACCTACCTCTCAATTCTTGTTTCCTGGGGAGGAGGGATCACCTGCACTGAGATGAGGCAGTTTGACACAGATCACAAAATAAATCAAAGTCTTTTTAAAC + ,($,*$(&')%(.-*+111/,$,0.*(%*50+,*)/--23.)1-533/',(.302/5(451,0420223&5/)$0.+('04.5241/+%,0+.300642,+1-.#(..++'00&,(1122620.364*.)-000)3011/20&),.("$$&-$1.-.3&').22)11,(++-*2/6&358,995376406,3853141/89;562'46-'6+/261&252)+.,54%%/22*766,/,22203477'8.8306:35,4*&515-742'$2/2=,4,424?76(('(/:/(*)./.;4,7>>6153<43;>>;5/&0,387077=-7;114#*,::1;3(+%57/'305,54+&31824,3042/.26$603(,9)6431-.375&12.-#+/063445%:,855.1)5:114##+(4,8:,34-2/33&9459:3599/08-4:988-298(47677/*./%.64%7,6578:982(99984'34,51*/+92*%-308773-'6-46/68.+.385.(2:.271#/3%87:76::-58,/.76+7''44201059850-.%674:-9882/*43,)16,5--363489180&6.207,4)./08.67244:.6$./2+/9:8:030'.*6930,.,42237(7-262&37+2'41968:6+'0/7.19:,1.3847.8157:2-23252*27+2646-(.,2/&70110941%+5;952'2)24/458)9743-2.3.,7:44-,*40589.09656/./9229420647.65/4++5660402073+240/1397954+/%514*033(67512/%1.68:)-/61'388'444869))'279)7'*24,1994825,..5/4..-545/52+42&/41.)1+*0/,&25.'70-5152764+0%5/5."44763&3506-79.32&-64,72-3.-821/$88/8-*7:24$.$7:5-62'74/1'8(#!0#%)&$%02&11*287*73(7:.499773%2620/&3876:9:2*37+&5):895),#.)-3656<390>/<86/5846:4987,3'%7:;(,-/'598/66-0.+)258/46*285(1*2$59857--3.2690152*'104)56773-55)9;/,%,2-3/.-56-10&5961&+7*4356%2&.4/1664)7)3.36,&3%55(5:92)8-1%358)105+*3:414988+:443&-9915-6:741285356%(405:3108545942&5842(50,48*7055068430.3564'063&56::/:53899:%$4$7 @rCer/1555/25_1647_CCS ATGGGTATCAGCACTCTCTGCTGCTCAGGTCTAAGACAGGCCTTCTCCAGCCCCAGCCCACAAGGTCTGAAGTACTGCTCTGAAGGGAGTGTGACGGTGACAGTCTGGGCTTATTAGCTGCTAGAAACACCGAAGAGCCTCTCCTCCAAGGCATCTCTATTTCATTCCCCAGCAGTTCTCCCAGACCAGCAGAGACTGGGGAGAGGCCGCAATCACAGGCCAGGCCTGACCATTTCATAGCTCACGCTAACATTTCAATTCCATGAGAGTGGAGACTTTTCCATGCTACCCTGAGTGCCCAGGGTAGTGCCTGGCAAGTCATCAGCATTCACCAGATAACTGACACTGTATGACCACAAGCTCTGGGGAGTGAGGATGATTTCCAGAGCGCCCGCACACAGAAACCGCTGAGAAGGAAAGACGAGGCAGGCACTGATGCCCAAACAGAAAGACCTTTTGCTTCTTGGAGGCCAGCAGTCCTGGATGGAGCGCTGCGTTCAGGGGATGCGATGGGGCACAGACACCTGTCCCTCTTCTGGACCACATCAGAGAAAGCTAGTCTCAAAGCATCCAGTGGCTCTAGCACTGCCCCAGTATGGACCACCTGTCCCAGCCATCTGGCCTTGGTCACTCTGGACCAGATCCAGCCCCCTTCCCCAGGAAACCTGGCCAGGGGCAGAACTAGGCAGTGGGGTGCAGCCACCTTCTCTTCTTCCCCTCCTCCTCCTTTTTGGGTTGCAGTGATAATGAAGCTCATTCACTGCTCTTTTTCCAAAGAAATGAGAAAGAGGACCTTTTGTACCAGGGCTTGGATGCTCTTTCCTCTAAGTGCAAGTAAGGAGCCTGGGTCAGACAATCGGAAAAACAATTCTCTAGCCAGCCGGCTGGCAGACAAAGCCGTGCATCTGACACCCAGCAGAAGAGCAGAGAGCAAGCACCACCTCTCCTCGGGCAGCTGGGGGTTCGGGAAGGTATCTTCCTCCAGCCACAGAAGTGACTGCTGGCTCAGGCTGTCACCTGACCGTTGTTAACCAGACTGCAAGCTCCTTCCCCGAGCACAGCAAGGCAGAGGGAAACAAATCTGACCCCAGGAGCAAACTGAGGCTGCGTCTCTAAGCACTGGAACCAGCAGCCCAGAAGCACGGGAAGGACAGTGGCAGAGCAGGTTGGCTCTGCCCCTTGAAGAAAACGCCTCCCTCCACCCCCATCACTTTCTTTGGCCCTGTTTCAAGTGCTGCCTCCTTCAGCAGGGGCAGCATGATACAAGGGAAACTCCCCAGACCTCCCAAAGCGTCCATTTATTGTTATTTTTATTATTCATTTTTTTTAATAGAGAAGAGGTCGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAACTAGCCGGGCGAGGTGGCGGGCGCTTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGGTCCGGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTC + 7E;>D=BBCBDBBEFCED5DB>CC>ABEGCGAGA>6F::9BFGD>2BBDD4D8CA?=@1@B?DD;B>0BBE8D617=CE6-@6CE>;7@@?A?D'B=B<=@:;EDC/1A>CD8ACEG?D:DA=><<4EC@DCDBAD:ECA;FD6C7DB>6DC@:9>BBAC;A??>DB?EGG1><7B4EAC=C8EDAA?F@E?8@1?6B?BCD5CDC=:9A=4B@BD?D/AED9CGB?6<&>5>@E<)<=/2;A?=>4>>A:E?A?CED8BCC>CA:F@EBE@9:?15@D<9DBC=*9?EF@EB@EDDFC98=>B>9:C.>6D>C4A=:CBE=DCC?4>2>EB+?C<8:9;DB=8<8=>88DB>B@:4>E?>C6@0?BCD;ADABEA>EBBFBF?;D?DE3EC=A<&<8F'ACCABBGG7D>@;>C5@D:3DAA??8DA9A9@@7;FB894BB?A5EE?.?AACAC=F>>B-BAC7>@7ECFEFG@2B8BAE:DBG;GFHEC?CI5:HCE$8:?DHI?IH=FFCG?FCHHFHFD1HAC3CGCHEG'EC(:94>@B&FD9>>AEIH;HI==ECJG;GAHB5EDA=@>GAHF@BGFJH6DG=G7;3?;?CE9@>C@CBBDC9;BD@=?A7>@0>A=4.>2A??9@;AB?:BD>?@/@A=?D54@C==55?BB>8:9DC>AD8;CAE7:=C79?D:>=BJF1GHBG7E>B54CFCIG=GBG7CG9E1@?@=GA@;F?>A8E>JCGEC4@AD>HFD;?DCDB2*9@E@;>DDAF=EDC>3@:@EE:DB@A9FG@@3B?>FGAEA5B6F;;@F<6BEC>?AEF@DAD;D55=790CGG>@ADBD;EE=EAFAB>B>B?AG97BF7F>EDD@6DDAACBBCC?@@B6>@5@;76AD0C8@@?E=>GIDE?@B@6FH?DDF6EBDHC*GCCEC=E6>A?G)?DDGJIFBE:BEEC55D@@EEEH8CCJGBBG;FFFJ=5A?HEGIGHH7G6?HDGGIFB0DBGKJ=:C7J:HFE@/FFDEFE@H>AJ@9H6EJCAEC4EGEECBBD;B?K>FKHF6GICECCGG8JJ9IJIIJ5GF>$C@#HGFEBDDG(DDCBGEI>E9I>KJCH5@KDEFICGFADDDHD>?BE4CI7FIAJICIKDIIJDKHI@KIG?FEJGCIKIHKJGJ-@GHD?FH3EFHF@79=AIGJHGJ@ABIJKD3I:>EGJ;ECH:KHBIG44EBD9?HJKHIDIGHJ.;(J>EEGJKJHI;IFKHEGJGJJJJEJE6EAKIEAKF@4+BG?H:GG;GEA@D@@GH@09@CBD@E>A<9CBGADHEAGKDA>HEK/D;IBBHJDADKKIIHEB<@JGD+@7CDDCCGEG6GGIC??HEJIIGEGID:GGD5HGICIGA;@>CFDHFHGHF@IG?FJECF@KEBJF;C=BA.EFIJBHIG?EHAA:IIKIKCHCKJKKDHCH:@;HIIHI:A:KIIFCIGI@A@)G<@@JGGCG?I7JJEF0J9FGCFEFHJJEKJEJBKAJKIJJKJEKHJDK;FIKIIHDHACHGIJJJIH=H9DIE=$<>>5IIJFJJ8DDIGJIKKAJKG:EFEGKBGH@BIHGGHKDCGCGAE@AGD@IIJ6HIJDJ4JIFHHB,CCIBKGGJKEIGHIJJKIAIAG8DHIJIKGHKKJJKGBEJHHHK8BCIGFCCHKJ;G?KAF7A2IJJE@FFDGE-FEE@FCEHDGIGD3:ICHG*IHGKEI=BDEIJHJDEB?AH0GHDHHIJH::*FDKHJFHEK@IJFIKKJJFKGE3JGDJJKFKKDJKKGKAKIHBEKFKKKBIHKKKKJ9AJFKE@JJKIKIKJHII@JHGIFDDJ=KKBAJKKI6CH?IIKJ@JDHJKEGHJ8JHFKKAEK2KKKJJDEHF@JJG.GKJK:KJEIKFKIKHDJ6KHIJIKKHJKKIKIK@JKFKK?KKKKGI;IKAIFEJKHKEFJBJJIHEKJ4JKKK=IKKKDJKHDJJEIKJJJBJG@GJHJF>IIDFHJIJ.KJJIDKHKJKJKJIBK=ICFKK<@K*FEGAJJ@>JED?JKKKDK2HIJEHKJ,KJEJJK;GH7KKK/HDKFKJKGJFDDJ7K-;JKJJJCKHDFKK1KJJJKJKK9FH/JKIFJHKK?IKK?HEKKEKGFFCK?KJICIHJKKK-JKJ9>GJGG.>EIKKFHGK&HKDKGKJKJKKKKJJIJJKJIJKCKIJJJJKKK4KKJIBIJ'KKHCGH6IKHJJHKKKKIJHJGJH@K@IHIJJJJJKKIJ%KBFE>J=CIJKK3JCKKJHGKJDJFCAEFKKKK9JKJIHKFIKDKKKJKIAIK:KIJK2GKJIKIJDJ;GHGCJ2C*IK=JJKKJIJKJD'FDD2D=J3FKK=JGIJJHCK7HKJICHJIHEJD%HKGKJJGJKIHJ8KIIK@KKJEGK@E5J:GFE8KEKK2KIKKI8FI?HJKHJFHJK8JJJGJKJJHEAHHDKFKJCCH4IFJK9JIDJFG:KJFIDECB5JHJGIKGKDJKHH@E9(DGGD>E5GFFBIIDF:DF9GBHIIE,BC==IHD>@%DDEFJFJG6E4IA@(EBCCIGE13BG=2EB)&CD?1ADH=IDGFGF7EBB4G7FHCFEF:JHEE4A:3E3>@GAE6J9AE>FG?GICJIEEDICH6HFC:CHB;ADG:H8E@3H;GAA9A?C8IE9CDFDA@?>=CFGG=AB%??@>>D3@8&A>>GI:C??F<2C9=BB:CAE;;97<=CG?74;8?<8/:??8@=C?;>/&269<<.49F@>@>D:?G>;:;$E>AHAICG=@DEH?FDHBICEE7AB@A==AEE=;@CCI9?&@DG>D:F7GIDECDB@/JEC>C;?F6+BEA=2>6::8?7*H-IAIG:CIFCD9FD?DB?:GCAACGD@D2FFEEGD>BDCF4DBE>@AEAEGEFF?IIJ?E@HA=IED>2@DHIE?1CAFIGHIA.IFGFF0GE4HJAB7H98B:8FAGFDHCE6IG@IJFBBIIFCFHHGFG>C$CC=2E6G=6A>HA;GHIFG=IHCGIHAJHFC;IGG=BGEIBJID>GFICID?86:DIICEHHG=GBJIFII3>EC@D=@1FGIIFJE>BBGIE>=CBDHFDEFGH==@C=:6DF@JC2:>DBFGE9EDFFHAE>/@BCHH=;DEC@IHEEHDF8C8<8CEBHI?II8D:>,FHCIFJAD>JGCB5GFGEEEB-G=;@EC?DH?E>FECJBIGJHIIB9=E4H6/HH6H:KJ6@:JJGFFDF>>EH0JEKF:BF8>FEI3HIJJEJII6JIBH?HJKHKG9A7HB5DFCJBHICF:JIBGK<:KKFHKK:KKIBHJGKAHBDKKIKDCJ>HJ=JKFEIA)F>GJEKJJ?HHBEHK@?IIFD<<.E7G=JBJ0KKJ;HA?IGJGG6IHEGF=FHJHD%F?JGJ??BFJD3HH@HFC$GD=HKJ3F1JJJGKKJJ9I6FAJ=,IJIJ-KCBBBIJIGG@CH-JIH<-JKKJJHKIEDEIHIDD:K9)@;FF>JIDHJJ@=B=K%HEH@C3FGKJ>1FFH>JIIJKAJJ?EEEE+DJH4HJKH7KG1KKKKBJ@DGADI=B8?JJIFJAJ4KIJFKHCKJHHGBEG3HKK3GFKJ;KGKHDCKFBCH6FIKIDBIJIGFGH:GGKJFEKEKDH;9<-HIKE7KCFJ;KK<=G9G?HEKIKHHJIIFI5KKCJHKIG=KK:IKKKGBKGGI*KHIKI5HEGDIAAHC/KKIJEJEKICKIKKKJ@K>KIJKKFKJJKJKCJJ@KI0C79CB8JHFI/HECFJFKKKJJBJJ+DDD>KKDKGIJD<@(BH@<>8H9GH+IJDD:3KKD4F6AFHIFFCEJG4IFH0KC=7GED7IGH?CFDJII0KJ;KH@CCC9DE0FKKF=?IIIIEC;ICD7BFDEIJKBDH6GHH?>>AF=8@B9AD@@A$?=>C;1,=G?B;IFF5@(;;>>EEB='EGE<5C:?>I?%:?@CHB8FD@H>C9BC@A4D2FHIDIB;FHJGEGG;G?'B;=BAG/54EI1D7EBEHB?D>AF?EFIECD1D;;5DGCA?GE8HHD0FFGFGEEDCEEI6FE@6IICCIG3AD(AG@AF1FCGFF@4A@7197.63:.;E93980'D:886'4::;0=:B>=E; @rCer/1559/25_2082_CCS ATGGGGACGGCCAGTTTTCCGCAGCTCGCCCTCACTATGGCGTCGCTCACCGTGAAGGCCTACCTGCTGGGCAAGGAGGACGCGGCGCGCGAGATCCGCCGCTTCAGCTTCTGCTTCAGCCCCGAGCCGGAGGCGGAAGCCGAGGACGCGGCAGGTCCGGGGCCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTTCCCCGCGCTGCGGCCCGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGTGATGGCTGCAACGGGCCCGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGTCCAGACTACGACTTGTGTAGCGTCTGTGAGGGAAAGGGCTTGCACCAGGGACACACCAAGCTCGCGTTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGCTGAAACACGGGCACTTCGGGTGGCCAGGATGGGAAATGGGCCCACCAGGAAACTGGAGCCCACGTCCACCTCGTGCAGGGGATGCCCGCCCTGGTCCCACGGTGGAATCAGCTGCTGGTCCATCGGAGGATCCCAGTGTGAATTTCCTGAAGAACGTGGGGGAGAGCGTGGCAGCCGCCCTTAGCCCTCTGGGCATTGAAGTGGATATTGACGTGGAGCACGGCGGGAAAAAGAAGCCGCCTGACCCCTGCCTCTCCAGAGAGTTCCAGCACAGAGAAGAACAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACGCAGTCTCTGGCAGAGCAGATGAGAAAGATCGCCTTGGAGTCCGAGGGGCGGCCTGAGGAGCAGATGGAGTCTGATAACTGCTCAGGAGGAGACGATGACTGGACCCATTTGTCTTCAAAAGAAGTGGACCCGTCCACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCGCATCTCCCACCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTTCCCAGATGCTGTCCATGGGCTTCTCTGACGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAATTACGACATCGGGGCGGCTCTGGACACCATCCAGTATTCAAAGCACTCCCCGCCATTGTGACCGCTTTTACCCACCTCTTCTGTGTCCCCCTCTTCTGTCTCGTAGCTGTTAAGCTAGTGTAGAATTGCAAGTCTCTGTACGGGCCAGTTTCTCTGCCGCCTTCCAGGATCAGGGGATCAGGGGTTAGGGTGGAAGAAGCCATTTAGGGCAGCAAAACAAGTGACATGAGGGGAGGGTCCCCGTGTGTGTGATGTCTGAGAAGCAAGACCGGTCTCCTGGGTGCTCTGGTTCCCTGCAGCAGGGCTGGGCCTGCGAGACCTGAGGCTCACCGCAGTGCTCCTGGCCCCTCCCTGCAGGGGCCACATTAGCAGCCCAGACATAGCTTGCCTAATGGCCTTCCACTTTCTCTTTTTAAATGACTCGGAGGTCCCTGACATTTAGTTGATTTTCTGCTAGAGACCTGGTACGCTCTGATTTTAGATAAAGGAAGCCTAGGTGTTGTTGGCGGGTAAGCAGGGGAGGCGGCTGTCCTGGCACAGGCAGTGGGGAGGCCGGGGCAGCCAGTGTGGTGGGCTTCCTGCTGGGACTGAGAAGGCTCATGCAGGGCACCCGTAATGTTGGTTTCGCTGAGAGCTGCCTCCTGGTCTCTCCACCACTGTAGTTCTCTCATTGCCAAACCATCAGCTGCTTTTAAAATAAGATCTCTTTGTAGCCATCCTGTTACGTTTGTAAACGATCTAATTAAATGGCATCAGCACT + FF>IIG7C>JABAF6III=EEFD==B==8:?FH?G<@;CGE6GFHCDGFGGFHIII=FAIFCCI9@BD-DDFEIHGCBIDDEH?HE8B@FGAF?AAGG?BE99DDFBB7B>=A4@>A>B<@C?@;==FDIE?DFGH08>9;@3.C33:EDGHIFE;->5ACC'<@=@ADA>?>E8+:93C=??E8;=;5?;7<9BGD<82-BA97:55>A9202=?DFIEHAC:>D:@:<<C<:>BB>;D>GA8A9A=>&EGHDB=@>AIGGDDE0GEG5?6=BDE;D)902338::48:15:,0;=>@?D>BGFB;D;:C,=C/=E8ID0@DB?II4HKHEGFEFFDHFIEI;?ACAD=A>DHHDEIIJIGHK&EHDIEI8GCJBKK@FHD%AJKKCIECEAGHGGKJKJFKDHCKKHKJKKJEKHCFCJHEGJJIIKDKKAEGIDIIDKKII(KKIIKEJFKKJKKFKJIKKHKIFK:DHKKJIKFKKKJHIIJKIKBKIJHKKKKJKDKKKKHDG=KKIKK'HJKJBFKHFJKAKIJKHKIKHKIKKJIKKKDJJFKJKHKCJG;HFHJHJKJDKKJJKKJKKIJ0KHHKKHJFIGKKD+9>IKKBJKKKKJIKKIKIKKK>KGFKKHKKKIKKKKJIJKJKKHIKJ>FGKBIJKJK5IIDJKFJJGI,DCG=:EGHJGKIIJJKGICCG:KKFDJCKKHKJIKKKIKKJJ@KJDKAKKKJKKKJKJ1KHJIIJHHKKGEJICHKKJKJKK9GKCKJHHDJ:IKGKKH5IKKJFHKJIKBKKKK:KKKJCJJA,IHJKGJ@GIAIJJFJKIJKJKKKJB4GGJ?GAI<@FJKK6KIIA5FIIAJ@K@HG>JFFJHJBFKJC@KJIKJKJKJGJJKIDFDKKIJJJKJ@JKJJHK@KIFK5KKJJ9JKDJKK?JDKEKHJ@DKDJJGGDKKJKKKJJKIJHJKHKJAKG@HDH?JFH@FIACG0DKKGKGHG4DADC:<:CABFGIDIKDKJ?KKEJKCJHJJKAKKIIEJIGEK6IEHH>ECBE2IGIB5IJJEGKJJAJ?H=EFJKIGJIIIIBJJ@IKIJ@HHECHFDJJJJKKJAKJIH?;GFA5II9G=:A/HFCKI:HKHKIKB:HKK:IIKHHIKKHJHKFKKHEHJJGGFHFGCAC@JG7EBJG*JGDJFAFH;E?C9GDEGF@>CHEIGHH7 @rCer/1560/1598_60_CCS CCACGACCTCCGTGCAGCAGCGAGGGCTGGAGCTCACCAACACATCTGCCTACCTCACCATTGCTGGGTGGAGAGCATCACTGTGTATGAAGAGATCCTGAGGCAGGCTCGTTATCGGCTGCGACACGGAGCTGCCCTCTACGCCAGGAAATTCCGGCTTTCCTGCTCGGAAATGAATGGCCGTTACTCCAGCAATGAATTCATCGTGGAGGTCAATGTCCTGCACAGCATGAATCGGGTTGCCCACCCCAGCCACGTGCTCAGCTCCCAGCAGTTCCTGCACCGTGGGCACCAGCCCCGCCTGAGATGGCTGGACACAGCCTGGCCAGCTCCCACCGAAACTCCATGATTCCCAGCGCCGCGACCCTCATCATTGTGGTGTGCGTGGGCTTCCTGGTGCTCATGGTCGTCCTGGGCCTGGTGCGCATCCATTCCCTTCACCGCCGCGTCTCAGGGCTGGCGGGCCTCCAGGGGCCTCCGGTGACCCCAAGGACCCCGACCTCTTCTGGGATGACTCAGCTCTCACCATCATTGTGAACCCCATGGAGTCCTACCAGAATCGGCAAGCCTGTGTGGCAGGGGCTGCGGGGGGCCAGCAGGAGGACGAGGACAGTAGTGACTCGGAGGTGGCCGACTCCCCCAGCAGCGACGAGAGACGCATCATCGAGACTCCCCCACACCGCTACTGAGGTCGACACCTCTCCCCACGCAGAGGGAGAATTCTGCCCTGGTGAAACAGACACTCCAGACGTGGGAGAAGGACCTTCTGGGAGAACAGAGACCAAGAGGGAGAGAGGCGTCAGAACCAGTCCTCCTTTCATCTCAAAACCCCAGCGGGCCCTCTGGAGTCTGCCCTGCCCTCCCCTAGCCCCCATCCCTCGCCTCTGGGCTGTCATGCTCCTGGTGTGCCCCTTGCACTGGGGCTGGCTGGGTTGGAAAGTGGGCTGGACTTCAGTTGCCTTTCTACCCCCCAATGGCATCTGCCCCCTTAGCAGTCACTGTGTTGGGGAGAGGGTGATGATTGCAATGGCTGGGGCTGGAGCTGGGAGTGGGATTGAAGGAAACCCTCTCCTCTCCCCTTCCCTTCTCTCTCCTGTCCATGGGAAGCTTCTCTCCCTCTGCAGGACTCCCTCAGCTGGGCTGTCGTCCCTGCTTCTCTTATGATCGCCCCACCTCGTTTCCATTTCAGTCTGGGGACCCCGCTTCTCCCTCCTTTCCAACTTCCTTCCTTTCTTGTCCTGTTTCCCTTCCTGCCCTTGCAGTCCTGAGGTCCTGCAGCCCCGGCCCCTCCTCTGTGACCTGGTGTGGCCAAGTTGCGGGGACGGGAGGGGATGTGGGGGCCCCAGGTGTATATATATAATGTATATTTTTCAATGTTGTCGTGAGTGCAGCCCTGTGTTCCCGTGTGCAGCTCACGGCCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGCATCGTCATGTCCTGGGGCAGGGGCGGGGGGATGGTGTGGTGAGGGAAGGGACATATCCTAGGGTTTTCAAATAAAACAATC + :,6;2':<;@??;C;.=9@C:?AA=+2.:5?9=B?>4>@8/2/0.>3B<9;?B5B>A;E<:0EB<;7(796ACBB:B?55=>,45JJCGEC>E?A6E=8BHHGEHB8JDEHAA?@AH:ID1I>BB=6FEH9GHFJI?G=01-%?8.?A=2EE=?1?E@C>>>CF@+.-)'>JH=@66D=?DG=JIIIGEHA3=?8?>:=E<>C=CJFB0A0GCBFIHK5?J/GDFHA0EAG>FB@IF@=E6;2AD>BGE?KKJCGD3D=9A<>D?;BE:D4JKK=D>DKB?EIFFH.G:IGJ<@@>7IGCICI=CJ3IJJHIKH6KIIDFII:EGB:;?C,BDJC9@@CG@=@5B@EBD=IDA?FIBCA=>=?@CFJJEKK;KIKEGKK=EFHJ>A@ADFDKIIFCG=G?ID?FF=G9DI@IF=@F?GA9?FCD<887AF@CG@7?AC3BE?EEJI3=@67GD7'DC;>8?DAJIG=FE?5IHDJFB:CKGE98<@HGDBJKK*,=E)=9B8?&;?=?%FHED5CDGF?6GC;4@GCG8C?9EKJBKIJGJJ'IEJHE:9JII(C7B4?GHGBFEFAIJJGACJIGEKHKHKKJ9E?CAH@HFI><;KH4BAKJ>JJBE><@>EIE::F>6@E:B9=JIE@>;D0<*BA?>F@KBH>IFH2KJIGIIJI=FKJGHKKKK;09DB,5C5?&AADIK6GAK:CA6J8IBK@KIC>F4@HKA=IECDKB9C*H>A@>CBB>:=840@:;AIG:CE>B3=/5:=&GGF@ABF>EDH=@GCA?9H:==BAIK;GFA3>CB@0A86?>>A:,1>D':>A<7.10)6&26&70>AA*99978624254=<3A9@=*.87>:@?? @rCer/1561/25_1845_CCS AGGGGAGCCGCCACTTCCGAGAGCGCCTGCAGCCCGTGCGCCGCCGAGCCAGCTGCCAGAATGCCGAACTGGGGAGGAGGCAAGAAATGTGGGGTGTGTCAGAAGACGGTTTACTTTGCCGAAGAGGTTCAGTGCGAAGGCAACAGCTTCCATAAATCCTGCTTCCTGTGCATGGTCTGCAAGAAGAAATCTGGACAGCACCACTGTGGCCGTGCATGGTGAGGAGATCTACTGCAAGTCCTGCTATGGCAAGAAGTATGGGCCCAAAGGCTATGGGCTATGGGCAGGGCGCAGGCACCCTCAGCACTGACAAGGGGGAGTCTCTGGGCATCAAGCACGAGGAAGCCCCTGGCCACAGGCCCACCACAACCCCAATGCATCCAAATTTGCCCAGAAGATTGGTGGCTCTGAGCGCTGCCCCCGATGCAGCCAGGCAGTCTATGCTGCGGAGAAGGTGATTGGTGCTGGGAAGTCCTGGCATAAGTCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGGATGCTATGCTAAAAACTTCGGGGCCCAAGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCTTGGTCCACTCTGAGTGAGGCCACCATCACCCACCACGCCCTGCCCACTTCCTGCGCTTGTCATCGCCATTCCCTTCCCAGCAGCTTTGGAGACCTCCGGGTTCATTTCTCTCATGCCTGCCACAGATCACTAATGACTTGAACTTGGGCATCTGGCTCCCTTTGGTTTTGGGGGTCTGCCTGAGGTCCCACCCCACTAAAGGACTCCCCAGGCCTGGGATCTGACACCATCACCAGTAGGAGACCTCAGTGTTTTGAGTCTAGGTGAGAGCAGGCCCCTCTCCCCACACTTCACCCCACAGAGCTCTGTTCTTAGCCTCTTGCGCTGCACGTCCACCAATCAGCTGGCCAAGACACCTGGGGACACATCTTGGCGCCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAAGACAAAGATGAGGAGGGGGGAAGGCTGGGTTTCTTGGATCCCAGAGATTCTCCTCTGTGGGAAAGAAGATGGGTTTCCTGGTGTCCCTCAGAGTAAAGCCTGAGGAGTCCCAGCTTAGGGAGTCACTACCACAGGCAGAGAGGCAGGCAGCGGGGGTCCTAGGAGCCGCTGCTTCTCCAGGCCTCTTGCTTTAGAGACTTTGTGGAACGGATAGCCTCCCACTAGGAGTGGGAGAATAACCCAGGTCTAAGGACCCCAAAGTCAGGATGTTATTTGATCTTCTCAGACATCTAGTTCCCTGCTTGATGGAGGGATCCTAATGAAATACCTGAAACATACATTGGCATTTATCAATGGCCCAAATCTTCATTTATCTCTGGCTTAACCCTGGGTCCTAAGGCTGTGGCCAGCAGAGCCCAGGCCAGGGTTCTGTTCTTGCCACACCTGCTTGATCCTCAGATGTGGAGGAAGGTAGGCATAGCCTCAGTCTTCATCCAAACACCCCTTTCCTTTGCCCTGCGACCTCAGAATCTTCCCTTTAACCCAAGACCCTGCCTCTTCCACTCCACCCTTTCTCCAGAGACTCTTAGATCACATCATTCCACCCCTTCCAGGCCCCAGGTTTAGGAGTAGTGGTGGGAGGAAGGGAAAGGGCTGGGCCTCACTGCTCCCCAGCGACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGCTGCAGGCATGGGCTGTACCCAAGCTGATTTCTCATCTGGTCAATAAAGCTGTTTAG 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rCer/1563/2393_51_CCS ATGGGGGCTCCGCGGCGGAAGAGGCGGCGGCGGCAGAAGCGGCGGCGGCGGCGGGAGCCGAGGAGGAGGTTCCGGACGCTGCTCAGGAACCGGGGACTCAGGAGTGCCCGCGCCTGAGCGCTCAGCTCCAGAGGCGTCATGGCTGAGTACGGGACCTCCTGCAAGACCTGACCAATAACATCACCCTTGAAGATCTAGAACAGCTCAAGTCGGCCTGCAAGGAAGACATCCCCAGCGAAAAGAGTGAGGAGATCACTACTGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATCTCCCGCCGTCCTGACCTCCTCACTATGGTGGTTGACTATAGAACCCGTGTGCTGAAGATCTCTGAGGAGGATGAGCTGGACACCAAGCTAACCCGTATCCCAGTGCAAGAAGTACAAAGACATTATCCGGCAGCCCTCTGAGAAGAGATCATCAAATTGGCTCCCACCGAGAAGGCCTGAGCAAGGGGAGGAAGAGGAGGAAGTTGGACTTCATCAGACCACTCCCTTCCCCATCCTCCAGGGAGGGGCAAGGGCAACCCACCATCTACCACTTACTAACCTGGTCTAAACCCCTTACTGTGCGCGTGTGTGTGCGTGTGCGCACGCTCTGGCTGTCTGTCTATATGTCTAGCTCATCTAGTTCCTCTTCTTAAGGGATGGGGTCAGGGGCTAGGGAGGGGCTGAGTTTCCCACTTTAGGAGGAGGTGGGGGCTATTTCTATGCAAATAGAAATCAGCACATTCCTCCTACTTCCTTTCTCCACTCTCCCCCATATCTTTAAAGTGTGAAGCAGAAAGGACCTGCATTTTCCTACATTGAGGAGCTGACATGGGGTAAGGTATGGGAGAGGTAGGTGGATCAGGAAAAGCAGTGGGGAGGAAGCAAAGAGGCCACTCAACCCCACCTGGAAGGGCAAAGAAAAGCCAGAGTTCCCTGTTTGTACTCCTGTGCTGGACTAGCTGTTTCCTGAGTACCAGCAGGTCCTTTTTTGCCTCTCATGGGCCAGCATAGTATGAGCCAGGGATCCTTTCCTGGCCCCTAAGATCAAACCCATGGAGCAGCCAGCATTAGATGCCCACCACTGTACTCTGGACTGTGCTGGGAACATGTACCACTGAGCTGAGATGGGGATGAGGCAGAGAGAGGGGAGCCCTTTTCCACTCAGTTGTTCTACTCAGACTGTTGTACTCTAAACCTAGGGAGGTTGAGGAATGAGATCCTTAGGTTTAACCTGCATCCTGACCCACATCTATAGGGTCCCAACTTGGTTATTACAGGCAACCTTCCTCTCTCCTTGGTGAAGAACATCCAAGCCAGAAAGAAGAGAAGTTAACTACAGTGTTTCCTTTGCACTGATCCCACCCAATTCAATCCAGGAAGGGACTTAGGAAACCTTCTTTACTAGATATCCTGGCCCTTGGGCTTGTGAACACCTCCTAGCACATCATACAGTACAGTGAGTGACCCAGCTCCTGCCTACCCCAAGATGCCCCTCCCCACCTGACCGTGCTAACTGTGTGTACATATATATTCTACATATATGTATATTAAAACTGCACTGCCATGTCTGCCCTTTTTTGTGGTGTCTAGCATTAACTTATTGTCTAGGCCAGAGCGGGGCGGAGGGGAATGCCACAGTGAAGGGAGTGGCAGAATCAAATTGCTACATAGTCCAAACAAAAAAGAAAGCTTTTTCAAAAAACATTTAATTCACATGCAGTCTCAGAGACTATTTAGACAAAGTTGAAGTTAGGAGCTTTCAGATGTGAGAGTAAAACTTTAATGGAGGGAGGCTGGCTGCTGGAAGAAGGAAGAAGCCAGACTGGTTAGACAGTATTCTTAACTCCTAGCCCAGCTAGCGTGTCCTGCCCTCTGGCCACTGCTGCAGACACTGCCTTAACACACACACCTCTAGGACTCCACAGTTTTGCCTTAAAGGACCTTCCCAAGTCTCCCTTTCCCTGTCTGGCTTCTCTTAAGAAGAGAGAGATACTTGTAGAATTGGTGGGAGGAATGAGCATAAACTGTCCTTCCATTTGGGATATGTTACATTAGAAAGAGAGAGAATAAGGAGCCTTTCTTATGGAAGAAATGGGAGAAGAGAGACAGGGTTATTTTCAGCAGAGTCTAGTAGTTTCTCTGTAAGGCAAAATAATCTAAAAAGACTAACCTGCCACCCACTCCTTATATTGCTGTGAGATTGCCCCTATCTTGTGCTCTTCTGTCTGCAGTGTGCACGGCCTTGTTCTAACCTGGAATAAAGGTGATTGATTGTATT 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rCer/1564/2151_56_CCS AATGGTGCTCTCCAACAGCGTGGCGGGAGCGCTGGTGCCGAGTGAAGGATAACAAGCTCATTTTCCACAAGGACAGGACCGACCTGAAGACCCACATTGTGTCTATTCCCCTCCGTGGCTGCGAGGTTGATCCCGGGTTTTGGATTCTAAACATCCCTGACGTTCGGCTGCTGCGCAACGGCCAGGAGGTTGCAGTATTGGAGGCATCTTCCTCTGAGGACATGGCAGGTGGATTGGGATTTTACTCGCAGAGACGGGGTCGTCCAACAGACCCGGGGGCCCTGCACTATGACTACATCGATGTGGAGATGTCTGCCAGTGTCATTCAGGACAGCCAAACAAACCTTCTGTTTCATGAAACAGGCGTGTTATATCTGCTAACCCATATCTGGGGGCACCTCCAACGGCTATGCCCACCCCAGCGGGACGGCGCTTCATTACGACGACGTCCTGCATCAACGGCTCGCTCAAGGGTAAAAAGCCCCCGTGGCATCTAATGGGGGTCACAGGAAAAGGGAAGACTCTGAGCAGTCAGCCAAAAAAAGCGGATCCTGCGGCTGGTTTGAAAAGGACAGCTTCGAATGCTGCCCAGTACAAGTACGGCAAGAACCGGTAGAAGCAGACGCCAAGCGGCTACAGACCAAAGAAGAGGAGCTGCTGAGAGGAAAGAGGTCCTGCGGAATAGGCTGCCCCAGCTCCGCAAGGAAAGAAAGACCTTCGAGCGGCCATCGAAGTGAACGCAGGCAGGAAGCCACAGGCGATTCTGGAGGAGAAGCTGAAGCAGCTGGAGGAGGAGTGCCGGCAGAAGGAGGCGGAGCGCGTCAGCCTGGAGCTGGAGCTGACGGAGGTCAAGGAGAGCCTGAAGAAAGCACTGGCGGGCGGAGTCACCCTGGGGCTGGCCATCGAGCCAAGTCAGGAACATCGAATCCACAGTCTCCAGTGTTCAGGCACCGGACCCTGGAGAATCGCCTATCTCCAGCTGTGACACCAGTGACACCGAGGGCCCCGTGCGGTGAACAGCGCGGCTGTCCTGAAGAAGAGCCAGGTGGCCCCGGGCAGCTCCCCTGCCGAGGACAGTGCTCTCACCAGGCCACTTGCATTCCTTCTACTGTATACGGCGCCTTTAGAAAGATGTACTTGTAAGACTTTGGTCCCAACTTTGTTAAAAAACAAAAAAAAAGTGATGAAAGGTGTTTGAAAAGGATGCTTCAGGCAAAGTGACATCTTTCTAACAGTTAAGCCATTGCTTTCACCGATTCCAGCCAGCCCTGGACTGAGGATGGAATGGTTCTGTGAGCCCCCAAGTGAAAACCTTTCGACGGGAAGAGCTTGGATCCCCGCGGCATGAGTGTGGCTGGCGCGTGGGCACTGGGCTCGCCTCGCACACCCACCAGGAGGGCCAGGGGCTTACACAGCCCTGACGTGGACTCTGTGTCTCGGGCGTACCCCCAGTGCCCGTCCCCCTCATCATCAGAGGTAAAGCATGAGAAAATCACGCTGTGAAACATTTTTTACTTTTATTATTTTTTGGACAGATGCTTTGTCACCAAGACATGAAAGCTGCCATTCTTCTAACCGTTTTTTTAAGAATTTTTTTGTTGTGTGTCACACTTAGATCTAAGGATTTTTCAGAGGTTCCTTATTTATTATTGTGCTACTTTGACAGGTAGCAGAGGTTTTAATACTTCACTAACAGTGTGCCCTCCTCCCCCTTGGGCTGGCATCCCCAGCCCTTAATCCACATCGGAGCCGGCAGGTGCTCCTCCACCAGGAGCCTCTGGGGGCAGGTCTGGCTGCTCGCCACTGACAGACGTTTACTGCTGCGTGGCCAGGGCAGTCCTTGGAAAGGGAAGCAAGTTCTGGAACTTGTTCCCTCATGGAATTATAACATCTTTAGAGCACGAGGCAGGAATTCCAGGAGCCTCCTGCCCTCCCTCTCCCTTCCTCCAGCTTGTCAAGTTAAACCACTAATGCATGGGTGGGCCTGGCCGTTGCTGCCTCTCCTGAGTGGGGTGGGTGCGGGTAGGGCCCCTTTCCCAGCTTTCTTACTTGCCTTCTGTGCAATATCGCTTGGAGAATCAGATGCCTAAGGCAT 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@rCer/1565/25_2349_CCS ATGGGGGGGAGCAGCGGCTCTGGCGGTCGTGGCGGTCGGAGGTCCGAGAGCTCTGCTTCTCTGAAAAGCGTGTGGCTTTCTGACTTGTTTCAGGCCACCCACGAGCCAGCGGGAAAGGATTGCCAGCCAGAGAAAGACGAACTCCAAAGTCCCAATGCACAGATCAGCCTCCAGTCAAACCACCAAGAGGAGCCGATCGCCATTTTCCACTACTCGTCGTAGTTGGACGACAGCGAGAGTTCGGGAACCAAACCTAAATATGATAATGAGGACTATTCCAGGTATCCGCCAAGAGAGTACAGAGCTTCGGGTAGCAGAAGAGGAATGACCTATGGACATATTGACTCTTATGGGGCAGATGATAGTGAGGAGGAGGGGCTGGGCCTGTTGAGCGACCGCCAGCGAGAGGAAAAACTGGCAAGTTTAAAGATGATAAGCTGTATGACCCAGAGAAAGGGCAAGGTCTTTGGCTGGGCCACCTTCACAGTTCTCTAGTTTTAGCCGTGATGTGAGAGAGGAGCGAGACAAGTTAGACCCAGTCCCTGCAGCAAGATGCTCAGCTAGCAGAGCTGACTTTCCTGCCACAAAGAGTGTGGCCTCACAGTCGTCTTCTGCTGAAGGCAAGGTGGCTACAAAAGGTGACAGCTTGGAGAGGGAGAAAAGGGAGCAAAATTTACCTGCACGTCCCAGCAGGGCTCCCTGTGAGTATTTGTGGTGGTGGGAAAACACCTCAAAGGTGCAGAGGAACCTGTGGTCAGGCCCAAAATCAGAAACCTGGCAAGTCCAACTGCGTGAAACCCAAAATTTTTTTTGATACTGATGATGTGATGAATATGCCACACAGTACTTCCAGGTGGAGGGATACTGCCAATGACAATGAAGGCCACTCAGATGGCCCAGCAAGAAGAGGCAGAGGCGAGAGTTTCAAGTGGCTATTCTGAGCCAAAGTACCCTGAGACAAACGGGAAGTGAGGATGACCAAGTGAAACCAGAAAAGGTGCCGAGACGACGACACACCATGGCGACCCTGACTCTGGACGCACAGTGATGATTACTACAAATACTGTGAGGAAAGACCTGACAGTGACAAAGAGTGGATTGCTGCTCTGCGTCGGAAATATCGAAGCCGAGAGCAAGCCCGTCCCCAGTGGCGAAAGCTGGGACTCTGCCGGGAAGAAGAGGCGGAACCTCCACAGGCTAAGGTAGTGCCAGCACTGGCACCAAGCCCCGGCCCCGGTGCTAGTGCCAGTGCCGGGGGCTGGCGCCGGGGCCGTGCTGGCAGCAATGGCAACAATACCTGAAGAAGTTCGAGAACCATCTCTTCAGGAAGAGCAGGCATCCCTGGAAGGAGAAATTCCTTGGTCCAGTACAATGAGAATGAGAGTAGCAGTGAGGGGATAATGATTCTGGTCATGAGTTGATGCAGCCTGGGGTATTCATGTGCTGGATGGGAACAACAACCTTGAAGATGACTCCAGGTGAGCGAAGACCTAGAATGGATTGGAGCCTCTTTGATGGATTGCAGATGGGTTAGGAGTGGCTGAAGCATTTCCTATGTGGATCCTCAGTTCCTCACCTACATGGCACTTGAAGAACGCCTGGCCCAGGCAATGGAAACTGCCCTTGCACACTTGGGTTCTTGCAGTGGATGTGGAGTGGCCAATCCACAGCAAGCAGGAGAGCATTGACGCTCTTCCCGAGATCCTGGTCCACTGAAGATCATTGGCGCAGTTGGTCAGGAGATGTGCTGCCCCATCTGCTGTAAGCGAATATGTGAAGGGAGGTGGCAACTGAGCTGCCATGCCACCACTATTCCCACAAGCCGTGTGTGTCCATCTGCTCAGAAGTCAGGCACCTGCCCTGTGTGCCGCGCATGTTCCTCCCCACTCTAAGACCAAGGCTGTTTACTCCTGGTCTGATTATTTTCCCATCTGAAATCCACAATACTGCAGGACCCTCTTGAAATTACAATGGAAACAAAACCAGTCAGTCAGTTAGCCTAAACCTATTGATTCCTCGTGATTATTCCAATGTGAAAACAGTTGTGTATGATTGCATTAAAAATCATATCATCTTTTAGAGGTTAGAAAAAGGGAAAACTAAACTTATAAAATGCTACTTGAGATTGCAGTAAGAACATACGTTTTCTAACCTGAAAGTTAAATCGCATTTGTTTTCTTCAGTAGAATGTGTTGCTGTTACTTGTAATGTCAAGTGTATCTGTTAAATATGTCCAAAAGGCAAAATCATTTTTGTTGCTGTTATGGGTCGATGTTCCTGTAATTGCAGTGCTGTAAAAGCTTATTAAAGTTTTTCTTTTGGTT 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@rCer/1566/2728_60_CCS ATGGGGGCCACTGCCGCGCTGAGGCGGAGTAGGATGAGGCCCGCGGCCGTGGCTCCGGCGTCGGCGGGGGCAGCAGCAGCTGAGGCAGCAGCTGAGGCAGCCGCGACGGCCGCGCCCCCCCCTGCTGACCTGGATTAGGCCCAGCAGCTCCGTGGCCGCCGCCGCCCCGCGGGGGGGCGGGGTGGGGAAGTGCTTCGTCTCCCCGCCCCCCCCCCCATCGCTGCCTCGCAGGAGGCAAACGCCGCGACCCCAGCGGAGCCCGCGGCCCAGCCTTGAGCCCCCACCCCCGGGGGCTGGCATGAGCGGCCCTTGGCGGCACCGTGGGGCGGTGGAGTCGCCTCCGCCTGATCCCCGGCCTGCCGCCCGACCCCACCTTGCCAACCGAGGCGGACCGCTGAGCGTGCGAACGACCCATCGCTGCTTTCTCCTCCCCCAGATCAGGAGCCGCCGCCGCCATATCAGGAACAAGTTCCAGTTCCAGTCTACCACCCAACACCTAGCCAGACTCGGCTAGCAACTCAGCTGACTGAAGAGGAACAAATTAGGATAGCTCAAAGAATAGGCCTTATACAACATCTGCCTAAAGGAGTTTATGACCCTGGAAGAGATGGATCAGAAAAAAAAGATCCGGGAGTGTGTGATCTGTATGATGGACTTTGTTTATGGGACCCAATTCGATTTCTGCCGTGCATGCACATCTATCACCTGGACTGTATAGATGACTGGTTGATGAGATCCTCTCACGTGCCCCTCCTGCATGGAGCCAGTTGATGCAGCACTGCTTTCATCCTATGAGACTAATTGAGCCAGGGTCTCTCATCTGACTTCAAGTGAACCACCATTTTGGTGGTTTTGATCTTTTGTCACTGAGCCCAAAGAGCCAGGGATTAGGAATTAAGATCATGCACAAAAGTTTCCTTAAAATTCCTGGATGGCTTGCAGATGTTGGGGGAAAAGTACGTGATATTTTAGAAACTTAGTGGGAAAAGTAGGATGGTATTTTTATGTAAAGCCTTGACCCAATGTTTAAAAAATAATAATTGTATTTAGATCTTGTTATTGCTCCAGTACATAGGAATTGTGTAAAGTGTTACAGCAGCTGTATTTGTTTAAATTGTGTGTATTGAAGATTAGGAAAAAGATAGTAGTTTATTTTTCCTAAATGAAATAACTTTCTTCTCTTCCCCTTCCCCACCCAAATTCTTTTCTGAAGTTGCTGACATTTGGGTCAAGGTTTTATTAAAAGCTACATTTTATAACACTGGCACACACAAAAAAGTAGTTTTAAGCTTGTTTGCACAGTTTCTTTTTTTCCATTGGAAATGGAATTCATTGCCTTAGGTCTTTTTAAATAGTGTATTATTATCGTTGGGGCTGGCTCTATGCTTGAAAACCAGTTTATTTATAAACCTGTTATAAGTGCTATATTCTGTTTGCAGTTAGGAAATGCAGAATTCAAAGTGATCTCCTAGCTTGTAAGCAAACTGAGATGCACTATCCCTTTTCTATAAAAAATAAGTTAATGTGTCAAGAAACCAACTCTATTAAAGTGGGGTTTAATATTGCCCTTTCCTATGTGTTTTATCTAATTATTTTGGTTGTTAATATGGTGATAATGGAAAGTCAAGTTAAATTTTAAATATTAAGAATTCTGATTTATTGAGATTGAATTATGCCACCACGTTTATGTAAAATGAAGGTGGCACCTTGGTGAGACCTAATGAGAAATAATTACTCAGTTGTAACAATTTTGATTTATTTTTCTTTCTTCTGACCTCCTTCCCTCTTGTCTTGAACCATAGCAAAAGGATACTGCATCTCTCATTACTGTAGTGCTGAGGTTATTGAAGTTATATAAAACACATCTCAGTCTCTGTTTCTTGGAAAGGTATCTATTACATCCTGCTAGCTGACTGACAAAACTAAGCAGGGAGAATAAAGATAATTGTATTTTATGTTTTGCACACAAACACAGAATTTGTATAACCATATGACTTCATAGTTGTGATCTCAAAAAAGAAGGAATTTCTCCTTTGTTTCTTGCAGTTAATGTAAGAATACTTTAAATCTCTAAGCTTCTGAAGTGTTAGAGGTAGAGATGGTCTAGTAAAGATGTAGTAGTAATGTTTTATCCATTTAGCATGTGTTTATTTTTTCATATGTACTCAAAGGTGACTTATTGGTTCACCTCAGTGATATTACATACAGCTAAAAAAAATCATTCATTAGCAAAAGGAAAAGTGGTCTCAACCTAACATCAGAAGTGTTTCTTATTATTATTTATATTGGGTTGAATATTGAACTCTAACACTTTTCTACATACAAAACACTGTCATGAAGGTTATGCATAATTGCATTATAGAGGAATGTAGTATTCATAAGTACTTTGTAAAGATTTGACATTCAACTGTAGTATCCATATGTTGCTTAAATTTCTTTATGAGCCCCATGATGGAAAGACTTAAAGATGAATTTGAGAAAAATTGAAGAAATTAGATGATCAGGTTCTGTTAAATTGTTACATGTATCTTGCTTAAATTTCTGTTTATTAATTTATATCCACCCAATTACATAAAGCAGATTTGGAGGAAACAACTGAGGTTGTGCAATATTTTCTGTGATAATTGCTTTTTTATTCTTGTGTTTTCTACTTAAACATGATGTCTGT 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@rCer/1568/1688_56_CCS ATGGGCAAGGTATTGCTTAACATAAAGCACCTGGCTTACACCCAGAAAATCTCAATACCACTTGATTGCCTTGAGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAGCGTTCAAGCTCAACACTAACCACCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTG 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G>BB=7B?GDE?D-;FA?8>??=B=.558?A3;;D8DAB>>@*<96??<4=AB;A;?AA>A<2;9;?>6:=>?BAC=A4<9>C?BC@;@>;?*@B959&<=@A@?>=;99;3:30;9<;:998>?7:=-=9/9538<<:';51;=5?:=<>><>;388669/<29<:;,9=;(*8495-<818;;8:=68<=6>5;<699=<<->?;<8'4=8?=9=4208>;<>?:>?9>=9>68<:*9=;/;5<=><><6897?75==<8463>;)=??7;2:;6<5>=26;7;*=>:;<49::+:><<;=:?=69077>==<877485<>=28>>:?;;698;==5:<==7869:<678;3;;:==:6<:=:;,<7=7<727;:6&6=79>96?;=:937><9:88)7/8=:8;>64;6:6/8:;=>==75=?;;?*>:;6>>856919;:7=<;4;8-1><:?<><;;>>9<8;+?==???7>=:8849879&;5?<:=9<=>?:7?>==9:<9>;=/946+.14$29:8>?8:>?=9799;86<=<>5<6<;<5/286<7899279;99=<3==?9;?<6;=97=9<736<=?3>=98?5;6:::)53=9<;3<9/3:48<=*;?3>>?>;2=>:>82:4:>>;:9>;<:1==6>:;;=9;44762;>4<::9=>796=>119695>9=8>=6;7,<2;-7<:/>9=<=<=8>;:2;7?:;=;?<<<<;7:):;;==2>97*(>>:=>>=7<;:<<379:&=?8=;==,<:4>>>>8:7;>;;56>=>>==>68=>=9:=:81999:>=>9;=9=<;;(9;=9>?>=>=8=?;969;7=9>:>;0(:689<<>=>976:8//<:::6888.9>-<8=678:4=>==<>670<.3<:<=;1;=3918:>8566:$=>;<7;<9<9>;<>??6;506>828:;279:?<=6>:=;=985;>?:*0>1;:3289888>59;=<179>;<9889=+7.8<98?<<787296>9==:72769>>=>;0/<&5:=99=39>6?=:;:=>4<;=6>5<>>:<3>=><-<<=085='>=:889>?7>><>=:8:;:::??;1>=8;1=?*(=&53>88974<4898106/=867<>>=8>???<>;<55<9<8>88)=:>>95.815=4==4:*79=6<=:<4782<3<>?7<;>62=;=>>8.6;=8::081;>:65==:?<>=><4=:;>>?=>=6;9>=9><<=7><>4>?53?;>=<=8;4<=99)3>=7==4;1=7679?=;;3><>?>>9=::=7:4===9;6+9>6;9=;>?=>;513=.:<3>>76>6295>=79.:19=;9722:::=;;69>>1=;8?:/1>3>8;<(9;?:=:>??5=:;716;?:>=<<4<67=:><96?:4:79<;8,/6=14/7;;;9:3:?=;<<:6%86:=6>;,4 @rCer/1569/2364_57_CCS ATGGGGCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCGCCAAGGCGGCAGGAGGAGGGTGAGCGTCAAGAGACCTCCAGGAAGAGCGGCCCCCGGCTGTTTGTATCGCCGATAGAGGTGCGGTCCGCGGGACGGTACGGAAGCCAGCGGGAGTTACGGCGTGGGGGTTTTGGGGGGGATGAAAGTACGCCTTTGGCCGGCTGAGAAGAGTAGTGAGGAAGCCGTGGCGTTCTTCTGGCTTTCCAAGCCCGAGGCGAACTTTGCGTCCAATGAGCACTTTGCCTTAGAGGGGGGCGGTCCCAGATCCAAGTTGGGCGAAAACCTTACTGGGGGGCGAAAAAGTGAACCCCAACGCCCGAAATGCATTCTGTTCTTAAACAGGCTCACAAACCCTTTGTTCTCTACCCATTCATCCTCCCCCCTCCTTCGTCGGGCCGCCAGCCTGCCTTTGGGTACGGTATGAAGGGAGCCAGTTTCCAGGAGCCAGTTTCCATGGTTACCCACCACTTGGCCTTCTGGGATATCAGTCACTCTGAACAGGGACCTAACTTGAACCATGAATCAGAAGCAAACACAGGTGGCTTCTAATCCAGCTGAGAATTTTCTGCTGTGTTCCAGTTTTTGGTCTATTGTTAAATAAAATTGGGTTTTGTGCTTCTGTGTAAGTATACATGTGTATACGTTGCCTTGAGCTATACTTGCTTTGTAAAGTACTTTGAGTTACGCGTGAACAAATGCTCAAGTTGCTGAATTTCACCAAAAAGTTGTTCTGGGCTCATTAACCCTCACTTACAAATTGTACATGAGCGATTTAACTGAGAAGTCATGGATGATCCCTTCCAGCCCTAAAATTCAATATTGCCTTTCTGGTTTCAGTCCTGAGAAGTTGAGTCAGAGATATCTTTACAAGTCTTTTAATTGACTTGTTTTTCTGTTATTACAGAAGAGAAAGGATGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTCCTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTTCCAAAATATCTGTATGAAGCAGGTGATTTTTTTCTGTTCTAACATTGGAAATATTTTTAAAATATCCTCTTTTTAAAGGCCAGTAGGACTTCTGTACTCCATGGTTGCCTACTATTTGCTTTATAGTCCCCCTTCTCTTGGCACACCCCCTTCCCCTGTGTCTCCCTCGCTTCTTTATGGTCTATTTCAGGTTCAGGAATTAGTTGGGATGGCAGATTTTCCCATTTTTAATTACCATAATAATCTCAAATAGAATTACATCTAGATATTAATTCCATTTTATAGAATAAGGTTGTCTAGCAGTAAACTATTAACCATTGGATACTGAAATAATTTTGAGAGGGAAGAGATATGTGATATCTGTTGCTGCCATTAGTACTTCTTGGTTCTTTCTCTAGAGCATTATCAAGTAAATATTTATCTCCTGACTTTGCCAGCACAAGCCAACTAACAATTACCTTTAAAATATGTTAAGTAAAATTAATAGGAGGCCTTTGGTTTGGATTGATCCCCCGCACTAGACCCAACAGACCAAACCAAAATGGAGTTACTCATACTGAAGTTCCACGCCACCAAGTCTAGAAACTAAATTTTTCATCTAATCTCCTGAGAAATCAGGAGAAAGAGATAATAGCCAAATCCCCAAACAGACCAGTTTAAGCCAGCATCAAGAAGTTTCCTCTGCTTTAACTTTTACAAAAAAAGTAACTTTGAAATTAGCAATCTGCCTTTTATTTTCTGTTTCTACTTTCCCTTAGCCCTTTTCTGTCTATACAATCAGCCTCCTCTGCTCAGCTCATTGGGACACTCATTCTATTTTATGAGACGATGGGTTGATGTGATTCCAGAGTTGGAATCACAAAAGCCAATTAAAAATTTTTGGTCGGGCACGGTGGTTCACCCCTGTAATCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGACAGGAGATGGAGACCATCCTGGCTAACACAGTGAAACCCATCTCTACTAAAAATACAAAAAGAAAAATTAGCCGGGCGTGGTGGCTGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCAGAGCTTGCAATGAGCGGAGATCGTGCCACTGCCCTCCAGCCTGGGAGACAGAGCGAGACTCCGTC + FCFDE-?D/@CE6ABE?@9C:=>=BE>=EEC>AA?FEFFEF@AF,FDCCCDF;F9;GCEFBA;BC@@=D9B=CE??CB@88ACB>B@?06><:E>D<;?F@E:D>@EB5EDBC6E6C=AGEBD;A;@FG9BE5@DBB:;CE>;@AC=<;D5@BGD?@ED@?6AFFGG@=?B>>EDBC>CAADE3?EF2FGGEGG3B7C>89A@@EC<:AC/@?B?F4C:AEEC1C@FA>@=?DF@EADGADBGDA:BBEEDD?C;FCF4B@G=A?A*CBGDB@GFBBC??=?DGAIBIHCGDHBII?EIEJG>ACCFFID.AJGIJG=HGEFIDI@GH8?H2GGGIH;GGJFHDBJF@HG6G;EFDGIEEFG8IIIHGH@CBAB8HIFDG@D>II=JH4C?@FIID=CH;HI8GHIFHGHE5IBHI?GIGFI?HD9FDEFF3FA?FE3CJDGID;HECBD;HIIG@HDGFEBB=H>HIAIFGH,IHEDF0?H;HG;IFFEI8;FGF5DAIJ?HGJFIEF?H?HIED?EH:E@D;?EICFD@5BAEDDE,HI@IDHIFIII@FHDE>DJGEIIIH=GBAB@D7DAGHEDG?GH?CD7=CG.IEH3DFHGIBEBABHDGC7C?HAFCCF.AJIGIEDFDFF3HBI>IIIG=>EAA1C;=IIGBIH1HEIFIIA@FDJ;GJ?EHIHHHIHC?HC?HII:CGJCIHEIIG@HDC5IGFC7FIHFA18BEFHGF>@G=IHDFEIFIAIEGFHIHDDHF@-;A6=GD->F=IDB@GF>GEG?HJGIBICDIJIEHHJIEEHC4>IIIHG0ADHAHIFIGEIIHIHC=EG;CADFFDBIIEJGEFEGEIIG>FGAHCIHBIHG4H@HG@DHEGHHFCH%FEDF7G7C3AFI>D-JB5F?DGC@*>HBIFHHEDBGAHIGEH?@G3FBHCGFG6CGFH<:@<@6AJF@/D>D@?B5G>C6<8:BB>.?,CBB<@BFICCBGF5FEHDJ9CCC*D/HAG>GFE6D@;BDEGI3GFJCFI@?EIHIJDHIHDHE3DEFF:HEBFC@DDEIIE=G>@EG+GGIIJIDI9HEC=>CFH8EDEGIGIFE@EBABF9IDGEIJJDBBDD?DAAEBG-CGHHGHFGD:HFBC6GCGIH@HBDGII@FF?8EF?BCECDC+EDIGHB?JFFFI?BAG?F?HIAHIACIEJFBCIIG>G2I>GIBC9>FDAHGII>@E<928@B9AAFDIFCFIDH?FFHJFFEBDF?=:1?H@EIBFIFE=II;HDGIFHHIIIEHEHJFICBG:FG9HIBEC:.ICIIECCGI.IBAHGI6AAHGGGCE%GGHCGHF;BHI:JIIGF;';FEBF@EIJ:FDHC,FIHIJAFF;DIJA=C=F2CGDE3FGI9DFIHCCCGCBFFH1GB@>GIGD?D;6IBC75DCDC=IE?GIIDF0FC@@EDEH=JIIG=IIHJEIEIIIIGJJ3GJCI9EBHDFH@IJJJ3BBCCEC1DCCJ@DG=IBHDAFH9BFEF5AC+AGD;CDH5BC6EH?G@GHI9=AC>IGHFHF?CC=IACHHIC581CF4A??IDC:H@DIE7GG>BDHEB?FJB:>D$CBAHEFFDIIDDHGDCFIFH<<7IFJGHEFFCC0CE<;?)>=GHGEIIDG@FIEGGHFI9BFJIDCJEBJ>FG:GH?HJA8=&BFHBCIIE>KFEIH@JIC@)G=*'E*4IKCD;6IB8&63GGB#K'5C0BF8H;KI)EDE.?ED>(KKFH;GIF&H@F%H=)C;KBKH9=C97I8JDIC+GG;%I4H0D3FA45.;J3G?KIE2/D=DD9?'BDGB?EB7F3@&%&EGF?JG>.DB;9D;H4KKJKK>JIBJ5KHACHCAKJIIJHKJJ9KJH4K?GJ9GC>6I38*IAFJ,KKIEBHH0KJ;K:JH/GE-CEGFDEHGIJAEB.HGK6'G7I@G)<:J>GKJKGJ?JAHKA@6*J?HK>KIFBJ(D<:J%KK9JJG*JJH3D5FEC4GH@4F>=AH?)KKJIJJFJJC&I2DBGE.@:;C?6?4:HKAGFKJGJCHIIE;2KFG.K1J;5093<8BD<+334&;DI/KJJKHGJJJ%HGHHJI6DGEDJ8KEHIJJJK8JJI7IKKI3JJKJH*G;?0JHJFKI:K3J@?9'=661>IKK6JEKKKKDFI3?IKKKGHIKK:KH&KE?)G5H9FFH/G>9DH5K%CEI6@C.C>>(E5EII0KKJ5JJH/J@=(HJF?J=2K?IK9KJ8KG:I?E)=FKH@3KIEJBKH3>6@FFH@EIKJB.FBHEHJEI=>G.7EGIIH8#DC@52CB6F%I3$FI*KC/1,8J;2JK?-EDJG6?BHJ.IKIJJKEJEH8J069H?DJ@I,KIA7(JEDGJ+GHHAKA5JJGCK@EC7HD8BE?C?IE>KKDKI.HG>80EIIF+I9%F=%=2F-EC8H7==@B=5K9IG=FFJAK4E?DIHH@=9I&=CD5JJIEJEH9/7EJB)JD0F-G:B6JKIHH.K<D=K7KKKK=6@:K(HKJBJJIH>I>2=CDEJIK;K86$JJ:D0KK73FGGEAFFJJKA(IC3DGCF?.EJ>@<<1G5K>IHCDEE-JIGGC)@FEG8F=DI8AGIHEIJ8?EFJJJH=GBJ6IKJ2K=67AFDH7F5;J%HGJ@?JIIC5E<+E/KD7J8@AF?%:6H?KIBG/I(HK=8ICKHKK1KIB?KHJGKJGDGE:GEEIKI2K>KIGHK7IKIGG=D/'JG-3GKK>KK<-KJ7IJ9KJ?KJJ@KFH/K:JE.KK<.FGKJ'KK?&(CBE.1IKJF3J5,JJG&JK=K5KG*JJK,K3KKGKK8AJJ=HJJHGJJ/KKD1EJIGIJJJ?K5GHEJF4K;FI4D>F5?$GGIHHKKKIJ;J8JKJKKJKJK @rCer/1571/25_1949_CCS ATGGGGGAAGCTGGGGCCCCGCGGAGGTAGCAGCAGACGCCTGAGAGCGAGACCGAGGCCCCTCAGGGTTTTGGAGACCCTGACACACCCACCTTCTCACCTGGGCTCTGCATATCCCCCAGCCTTGAGGGAAGATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCAGAGGAGCCCGCCAACGAGCTGCCCATGAATGAGATTGAGGCGTGGAAGGCTGCGGAAAAGAAAGCCCGCTGGGTCCTGCTGGTCCTCATTCTGGCGGTTGTGGGCTTCGGAGCCCTGATGACTCAGCTGTTTCTATGGGAATACGGCGACTTGCATCTCTTTGGACCCAACCAGCGCCCAGCCCCCTGCTATGACCCCTTGCGAAGCAGTGCTGGTGGAAAGCATTCCTGAGGGCCTGGACTTCCCCAATGCCTCCACGGGGAACCCTTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCCGGTGCGCACAGCAGCCTGGACATTCGCCTCCTTCTACTGGACCCTCACCAACAATGACACCCACACGCAGGAGCCCTCTGCCCAGCAGGGTGAGGAGGTCCTCCGGCAGCTGCAGACCCTGGCACCCAAGGGCGTGAATGTCCGCATCGCTGTGAGCAAGCCCAACGGGCCCCAGCCACAGACGGACCTGCAGGCCCTGCTGCAGAGTGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTGCATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTGGGCAGTGCCAACATGGACTTGGCGTTCACTGACCCAGGTCAAGGAGCTGGGCGTGGTCATGTACAACTTGCAGCTGCCTGGCTTCGAGACCTGACCAAGATCTTTGAGGCCTACTGGTTTCCTGGGCCAGGCAGGCAGCTCCATCGCCATCAACTTGGCCCCGGTTCTATGACACCCGCTATAACCAAGAGACACCAATGGGAGATCTGCCTCAATGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCGCCCCACCCCTGTGTCCAAGTGGCCGCACTCCAGACCTGACAAGGCTCTACTCAACGTGGTGGACAACGCGCGGAGTTTCATCTACGTCGCAGTCATGAACTACCTGCCCACTCTGGAGTTCTCCCACCCTCACAGGTTCTGGCCTGCCATTGACGATGGGCTGCGACGGGCCGCCTATGAGCGTGGCGTCAAGGTGCGCCTGCTCGTTCAGCTGCTGGGGACACTCGGAGCCATCCATGCGGGCCTTCCTGCTCTCCCTGGCTGCCCTGCGTGACACCCATACCCACTCCGACATCCAGGTGAAACTCTTTTGTGGTCCCCGCGGATGAGGCCCAGGCTCGAATCCGTATGCCCGTGTCAACCACAACAAGTACATGGTGACTGAACGCGCCACCTACATCGGAACCTCCAACTGGTCGGGCAACTACTTCACGGAGACGGCGGGCACCTCGCTGCTGGTGATGCAGAACGGGAGGGGCAGTCTACGGAGCCAGCTGGAGGCCATTTTCCTGAGGGACTGGGGACTCCCCTTACAGCCATGACCTTGATGCCTCAGCCGACAGCGTGGGCAATGCCTGCCGCCTGCTCTGAGGCCCGGTCCAGCGGACAGGCCGAGGCCTGCTAGGCCCCCACAGACCCAGATGCTCTGGGTCACGGTCCCTGTCCCCGTGCCCCCGCTTCTGTCTGCCCCAATTGTGGCTCCTCAGGCTCTCTCCCCTGCTCTCCCACCTCTACCCTCTGCCCCCACCGGTCTGACGCTGTGGCCCCAGGACCCAGCAGAGCTGGGGGAGGGATCAGCCCCAAAGAAGTGGGGGTGCATGCTGGGCCCGGCCCCCTGGCCCACCCCCACTTTCCAGGGCAAAAAGGGCCCAGGGTGATAAGTAAATAACTTGTCTG 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14*53541001-(//0'.252+613498133564/58020+/04*/323411190)*6/792+14.46%1.+,31092358---4+413796745+/+5523)35*.55+34/10$3763+)*8-3/0(11)1*029/8003--401.54+...,4,-/+135:8;23)636/562694635(680*4.832/.22.-44+4,,05384946-+*.,'/&1*046251/3217546.//,%.(1,00684-54.54223084/51767995.5+54:1678-86%.35)4731349,*.1/10.+./90473(1.1492-27-76347676(654%7212/(+2)1(:8941-6442+67.0',3.3%36&614'*.44/30,.0.4%7+00(.1/324(4-//4.()2888/8576,0,4030245-00/.25&3*-',-2-+,)/43737133+/0628;62133,54'(0.22.,+.+-*/0/'(('/(3046+53&%**('%%*,&)+...0/-)/,--).322/',/-,+'(*+(*11/51(-//0/./*.-'40.242'03024/40260/+))+(141:40/2)./,'.1.741')((0).1(.3&(/271224,1(/,,000-244(4727:197441383336-9.56847--/56689,,,/5:2-1)76/,68052$238595776;::62--513(%1(524,73:967'0/622-1.()#*/..*41/0/42&1**/.66'51-82+//02'1004.3./65.1,20.063220,4428/652%./6/9090.+0/2,.36,52434+.*113(2.),4,8-/0/)0+3,20&.02'$+,0+./.53&/133.,'+3.112).*&&)')+..%-''*)3.'+$&).1-*/.)4--/#(%)+0,',**&%%#&,(+0+.,/5/5&*-/+-122,..14*025614+'+*+.0)''+0*430.$.,#+.250,.15/11.+3154&0(-)1,/-0--../41/&3/+20/*/1411&2./.*,+-+-14.*1(+00/2*/*&+&%(+'0.344,"!#&*10411053*.605243425-()/2322)),*-3423*.#,,*3250-231440,)0,,+/65-154.00//),+3*+**#$*+,.*.5-22,3%/.1,/*/1-+0.14,-//23+41-*///.-.+-+31/3.)-'2+12/&/.1,/#3)42/1,)*./-532%).-.+%'-.),02..00--*4,00102/84&+,'-427.8.535230/$$+.,.032&21,3525332'$'2371$21.-359582..095-&-0-./&/1%12114547$12+1-5:/63.1:*0*58;206,..+(920(32+011./.4)*'5371434513.))(/743&)7315,641-+2+2+(%332(0,3$-/.719850:43674906,/12.5404,0..'&252369(3(5*440-1/153421/&'1110-'4-*-45013,-/0,*1533015451*3.24-4/*8633,444-57)-0&-3002++2+/',+.175;8711,7(-03404:4820003864345436365762.33,'1)11487471&10565;24,6263.16+%1460727**'0051-.-8,5:::7223,-223/(+86:443378163/:3/88073(554259-6755315999415:4-888%469679;3168:685:263932$)*-/33.+1,430(((0-+(.&231425/065720:5983726821/49.6:8542,)682/638.53()477/-)4986402%64203300.151520-3-,/.495.572;5780:8:5319.544'288615(76.9526:4155:52280864.1656:83970'1121,1.438132 @rCer/1572/33_2435_CCS ATGGGGATTCAACGGGGAAGGTGAGGCGAGTGAGGCTGGTGCGGAACTTGCCGCCCGCCCCCAGCAGCTCCGGCCGGCTAAGAGTCCGGCAGTACAAAAAGAGGCCCGCCGCGCAAAGTAGGAAGGCACGGCCGCGCGGCGGAGCGCAGTGATGGCTAGGGCGAAGGGGCCAGCGCGCATGCTGCTCAGTGCGGGGCAACCATGGCTGCTCCTGCCGGGTGCTACTGGGCGCCGAAAGCACCAGAGGCCCCGGGGCTCCCCGCCGGCCGGCATGAGGCGGCCGCCGGCGGCTGCAGCAGGATAAGGATCGGCATCTCCTTCGAGATACCAACCGCTACCCCGAGCTGGCGCGAGGCGCTCGTGTCCGTGTGGCTGCAGTCACCGCCCATCCAGCAGGATTTAGCACAGGTGGGGCGCAGCTTCGAGGGCCGGGAGCTCCTTGGTCAATCGATGCTATCCCGACAACCCTGGCGTCCATGAGCCTGGAGTGAGCCTGAATTTAAAACATTGGGAATTATGCATGGGAATAGAAGGACTGATTGGAAACGGGAACTGGCTCAATTTCTGACATAAACCTATGCAATGAACCAGAAAGGGGAACGAGACAACTTGTAACCTGATACCAGCAACATCCCGCATTCATACAAGCCTTCCCACTGAACCCAGATGCTTTGAGAAAGGCAAGCGTCTCAAAAGCCTGGTGAACTCAAAAGACTGGTTTTGTGGGTCGAAGGCAAGCCCAAGGGAATACGATCTGAAACCGGAACTTTCCAGACCTGGATAGGATAGTGTATGTGAATGAGAAAGAAAGGATGGTCCAAATAACATGCTGTTGAAAAAATAGAAAGAAAATTGTGATCCAAAACACAAACTTGCTCCGTGAAGACTCAAGGCTGTCATTCATTGGATTATGGATATTCCTCTTTGTGCTCTCCTGCCAATCTCCTGGAGGAGACCTTGTGGACAATTATTCCCATATGATGAGACACGCGGAGGTGGTAGTGCTCATGAATACAGCTCCACTCCCAGATGACGCCATTTCAAAGCTGGCCCCGGGCACTATCTTGCTTTCAAAAACCATCAGCCATGTCTAAACACCCAATCGCCACCAATGCGCCAAGAATGATTGATGACAGCAGCTTTGTAGATGGAACCCACCAATGTGGTGCTTGGTACAGTTACCTGGAGGAGATGCAAGACTTCAATTACCATTAGCAGCAACTGTTTTGAGATCAGCCAGTGGAGCTATAGCGTGGTGAGAAGTTCCCAACCTGAAGAAGACTCTGAAGACCTAACTGGGAGATAACAAAAACTCCCTCATTAGCTACCTTGAAGCAGATACACCGAGGAGTCAAAGGATTTGGTCCGAGAAATCTTCAAGGTAAACACAATTGCCAATGCCACCAATCTCCGTGGAAGGAATAGACCACGAGTTACATACACCGCAAAAGGAAATGGATGATTACTGGGAGATTGGCTTATACCTGAAACTATAAACTTACAGCCTCAAGCTCCAGCTATCTGGCAAATAACAAAGAAGTGATCAGTATTACTTACAGCCTGCTGTTGGGGAGTTGATATTGAACTGGAGTCCATTTTGTTCTGAAAGGAAAGAAGAGGAGAAAGGAAGAATTAATGAGAATAGGTGGAAAATTGATGTCAAGAAACTTAAATTTTTAAAAGGCTTCTAGCTAGCGCTTTAAAATCTATCTATATAAAGTAGTATGAATGTATATGTTGGTCTTTATTTTTAGATTTGTGCAGTTAATACTTAACATGATTTATTTTTAATCATTTAATATTATCACAATCCATTACTTAAAATAAATAGCCTCTTGAGGTAAAAATCAATAAGAAACTTGATAATTTCTCTCTTATATAGTATCCATATTTTTCCTACCTATATTACATCAAAAAATATAGAAAAGATATAAGTAATTTGCCACCCTAGGCTTACAAATGTCAATAGTCATGGTATTATTTACATGCCAGCAACTTTTTTGGGTAAATTCTACGCTTTTAAAAATTAGTGAAAAGTTCTTTTACTGTAACTGGTGACAATGTCACATAAATGGATGCTATTGAAAAAGGTTAACAGATACAGCTCGGAGTTGTAGCACATCTACTGCAAGGCTTAAACAATTCAGTATAAATTGTCAGTTTTTTCTTGTGCTGAGACTAACTATAGAGCGATGATCTTGTTAATGCATTTTTGATGGAAGAAAAGGTAAATGCTTACAAAAGACGGATTTTATGAAAGGAATAAAAATTGACTTCTTGCTTGTACATATAGCGAGCAAACTATTATATTTTTAGTTCCGTTACAACCACTTAAAAGTTTAGGTAGTTTTCTCTTGGTTTGTGGCAGTGGCCCAAAATAGCATTCTGAATGACAATAAAGT 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@rCer/1573/925_52_CCS CCAGGAGCTCAGTTTTTTCACTTGGGTCTCTGGATTCCTGTCATAGGGAAGGTGTATCAGGAGGGAAGATCTTTCTAGAATTTTCTTTGAGTAGGTTTACATTTAGCTTATATTTTTGACTCTGAACGTGAACAGGCTTTTTGCTTTTTCTTTCAGACCCATAGTAGAGCACTTTTCACTTACTTGGGGAGGTTTCAGGGATCTGTTCTCACGTTAACTCAGCCAGAAAGATGCCCTAGTTGTGATAAAAGGTAACTCGAGGTGGAGAGTAGCCCGGGCCCTCGACATGGTCGTCACTGAGGGAGGCTGAGACGTGCGCTCCTTGCTAATACTGTTGTTTTCACTTCCTGGAAGAGGCTGGAAAAGGGCTCAGAGCTGCTGAGCAGGAACTGGAGGTGACCCATTTCAGGAGCTGCTGGTACCAGTCTGACTAGTGCAGGCAAGCTTGTGTGGCCAACAGGTCCCTGATAGAGCTGGTGCAGGTGTGGCTCAGACCCTGGGCATGATGGCCGAGCCACTCGGATCCACTGATTGGCCAGCCGAGCGAGAAGCAGGCTGCCGCATGCACTGCCTGCCGCTTCGAGCTTCCTCTGAGCCGCAGGCCTGCTACGCGGGCAAGCGTGCTGCTCTCTTCTGTGTCGTTTTGTTGCCAAGCAGAATGAAAAGTCCTTAACCGTGGACTCTTCCTTTATCCCCTTTTATCCTTCCTTTACCCACATATGCAATGACTTAATTTTCACTTTTGTAGTTTAATCCTTTGTATTACACATGAAATATAGTTGCATATATGGACACCGACTTGGGAGGACAGGTCCTGAATGTCCTTTCTCCAGTGTAACATGTTTTACTCACAAATAAAATTCTTTCAGCAAT + ;(84164,25'279963'.0.459;85-5624-49/8,,48.86367&:49*774,8453.084'845$5%/705668;7:7:5898)44.8:;990&-,$(3(36571-1124.0'99-7649:243*47+761)&7695+),3443%./-*&,'-21%451475/885.0889-43,322251463&/.(14%9499+4584-7*687.'8;64'254-/4.3&65/562.5.*<24==9>76479=,9.9?91=95.8+76-@=C>B;*=B&6A(/B(C>;C;?<>.9:3B?=5648.;&B;4:=@:8386@9BADAA2B?%<=E;;<>@6D9.<>=(=999+8':?6A5H;BCHC=C#F?FDF*AHI,GGD38GHCE&BC2C=G@FC:HCB@GC;&36BAH5IH5<:@=3;:7@+>#--27B/9CG':<<>9,5,12@)7+'?;&4'%G28JGD;B$..F5<6)4)FGG59EI$;EFGJEBB*A;FAF?@IC.BJ:JD=IEF><+;9>DE;H-94;2<=GKI-8KCHF8D6&FBAGDGJKKF=3>A'K>H8G2?>E=E9=>A/K+JK0G><=<&FAF,E?<%A=H9D?&BCC*@DGDEAE3K8CAH9HK@IJCJI7A>HD960$??5IGH@EIIGCI@EH=@9?9BG@FDC5+CB7F1@I(BG(EHD@(AG4A8?A@C=H7HH32?H)EE?=?JJH;FJIKJJJG?E@KDKDKKGCFBJIF@IBIF?DI5JKDHED>D?JBIJGA=DDGI>9AKAJKBCF(HICKK9GIKICHGHKIGDFIJJ8KJEHG7GKKIKHAKIGIKHKKHDA3J@KHKIJHJ9KKKJKGKIJHKJIJHJKKHIKJJJ8KKFGFCIGJICIJ8K>?BKFGIKJJIJGFKIKKJ;E>JHHJK0HKHG9C?KAH@HHFJJEHJJJHCE9@FH?G-FF9DG?=IHJAKKKKGIHKKKJDKCKHKKDIADHKKKHFKBKJIJFKGGJ7=,FIJIFAJKKKJKKIFKJDJKKGJJIHCKJFFAJKKKKKKKKJIHHJEKKKJ?@DKKJHKHJKCKJAKD@KKJ@KJKGHFHHJ?J=HJFDKIKKKHJKKJKKHJ@KKKKKGKKKKK@KAHCIIKAJKJKIJKKJKKJJKKKKKKKH8KIBBJIGGKJAK?KKKKK?KKJHIJ;A?@DJJ>KJFKFIK1IBHJJJKKIJKHKHJKK8KKKJKJ&IHAKEKHJDDIKKIKFKHKJJKHJKKKKGKJKKKKKCKDKHKIIKKKKKKKKKKIDIJKKBGJKJKJJ=JHKKKK:KKFKKKJKKKKK?KFKIKKHK,KKKKJKKKKKKKJJDKJJKKKKJIKHKKKKKKKKHKKKDIJHKIJIKGDKKIJKKGKIJHJJG&HKKJHIHGICJK9KKKKKKKK;KKJJJKKFJDKKKGKHHK=IIKKKKIJJDEKKKKKKKKKKKBKJKKKKIBKKKKKIKHKKCKKKJKKKJK?KKJKKJFKGKKIJID;KKJKKEKKJJKKKHFKHIKBKK:J=KKK>K5K?KKJKKKJKKJ7KKGKIKJGKH>KGEKKDKGKKFJKKDKJKKC0KKIKKK3KKKJBKKKDKIKKIKJKIICJKKKH9DGKG=DK5KKKJKIKCKJKJFKKKJ5KKKGJKKKKCKKJKJHJKK&KKKKKJGKK>JGKKJIKEK3KKKF@KEKJKJHKKFKKHKD&=EKKJ>E-JKJKJDI?K%KK@I7KKKIHGKIFKKJKK1K @rCer/1577/0_2315_CCS GCTGGTTGGAGGCAGACACCCATCGAGGCCCATCGCATCCTGCAGCTGCATTCCTGGATTACTTCAGAGGAATGTTTGCCTGGGGGATTGAAAGAGATGGAACAGGAAGAGGTCCTGATCCACGGCGTGTCCTACCAATGCTATGTGCCAAATCCTACCATTTCATATCAACCTCCGAGCTGGAGCTCAGCCTGAGCAATGTGCAAGAGACACTGGTGGCTGCCTGCCAGCTTCAGATCCCAGAAATTATCCATTTCTGCTGTGATTTCCTCATGTCCTGGGTGGACGAAGAGAACATTCTGATGTCTACCGGCTGGCAGAGCTGTTTGATTTGAGCCGCCTGACTGAGCAACTGGACACCTACATCCTCAAAAAACTTTGTGGCCTTCTCTCGGACTGACAAGTACCGCCAGCTTCCACTGGAGAAGGTCTACTCCCTCCTCAGCAGCAATCGCCTGGAGGTCTCCTGCGAGACCGAGGTATACGAAGGGAGCCCTTCTCTACCATTACAGCCTGGAGCAGGTGCAGGCTGACCAGATCTCGCTGCAACGAGCCCCCAAAGCTCCTTGAGACAGTGCGGTTTCCGCTGATGGAAGCTGAAGGTCCTGCAGCGGCTGCATGACAAGCTGGACCCCAGCCCATTGAGGGACACAGTGGCCAGTGCCCTCATGTACCACCGGAACGAGAGCCTACAGCCCAGCCTGCAGAGCCCGCAAACGGAGCTGCGGTCGGACTTCCAGTGCGTTGTGGGCTTCGGGGGCATTCACTCCACGCCGTCCACTGTTCCTCAGCGACCAGGCCCAAGTATCTAAACCCTTTACTGGGAGAGTGGAAGCACCTTCACTGCCTCCTTGGCACCCCGCATGTCCAACCAGGGCATCGCGGTGCTCACAACTTCGTATACTTGATTGGAGGGGACAACAATGTCCAAGGAATTTCGAGCAGAAGTCCCGATGCTGGAGGTATGACCCACGGCACAAACCGCTGGTTCCAGATCCAGTCCCCTGCAGCAGGAGCACGCCGAACCTGTCCGTGTGTGTTGTAGGCAGGTACATCTACGCTGTGGCGGGCCGTGACTACCACAACGACCTGAATGCTGTGGAGCGCTACGACCTGCACCAACTGCTGGGCATATGTGGCTCCACTCAAGAGGGAGGTGTATGCCCACGCAGGCGCGACGCTGGAGGGGAAGATGTATATCACCTGCGGCCGCAGAGGGGAGGATTACCTGAAAGAAGACACACTGCTACGACCCAGGCAGCAACACTTGGCACACACTGGCTGATGGGGCCTGTGCGGCGCGCCTGGCACGGCATGGCGACCCTCCTCAACAAGCTGTATGTGAATCGGGGCAGCAACAACGATGCCGGATACAGGAGGGATGTGCACCAGGTGGCCTGCTACAGCTGCACGTCTGGACAGTGGTCTTCCGTCTGCCCACTCCCTGCTGGGCACGGTGAGCCTGGCATTGCCGTGCTGGACAACAGGATCTATGTGCTAGGTGGCCGCTCACACAACGTGGCAGCCGCACGGGCTATGTGCACATTTACGATGTGGAGAAGGACTGCTGGGAGGAGGGGCCCCAGCTGGACAACTCCATCTCAGGCCCTGGCGGCCTGTGTGCTCACCTTGCCTCGCTCCCTGCTCCTCGAGCCGCCCCGCGGTACCCCTGACCGCAGCCAGGCCGACCCGGACTTTGCCTCTGAGGTGATGAGTGTGTCTGACTGGGAGGAGTTTGAACAACTCCAGTGAGGACTAGCTTCCCGTGCCTGGTGTCAGAGGGAAGGGCGGCTGGGCTGCAGGGCAGTGAAACCCACGCAGCCTAGGCCACAGCACTTTACTCCAGGGCAGGCCCCCCTGCCCCTGTTGGCCACAGCTTGGGGGGCCCTGCCCTCTTTCTTCACATCAGCCCCTTTGGCCAGCCTGCCGCAGGCATCTCAGGGCCGTGCAGATCCCGGCCTGTGGATTACATCACAGCAGGAAATGCTTCTGAAAGGCTTTGGTCTTCCTCAGTGAGCCCTGGAGGGGTTGGCCTTCTCTTTCCTCCCTGCCTAGATCAGTCCTTATCCAAAGGGACCTGGGAGCTGACAGCCTGGGCAGGGGGGCTGAGGTACGTGGCAGCCCTCTTTCTGTGAATGGGGTGGGCCTGTGGGAGTAGCTGGGGTTGGAAGATGAGAGCTCCTGAGGGGCAGAGGAGCAGAGATGCATCAGCTCTCCTGGGACTGGCTCTGTGATAAAAAGACCCCTCCCGCTGGGTTTTCAGACCCCATGTTGTTGATCAATGAAATAAAGCATCTTACAGAAGGTGTTAACTG + S$$$""!####%$%%%%%"$""#%$##"""##%%%$##"!""""$$%$#$"!"%$#"$$$"#&&)(%(#'&(((#(%&#&'')$()(()(%&(($%%'')$%&"$(&-'&#(*'+'(%)+-+(())(++,(-,+$+**'++'$)(+*+,%*(,(-+-&(&$$"(),+'#%#+((++,)(*($(+,,'$(,(+*'%)*).,-,+((-%$+*,(*+(*++-''+++%').--,(,'*&)**..+,'++)()*(-(',+#&&,-,--,)..+.*)+)*'#&*+-*-*.,,'*-(',(&)+%&&#(+)(*'$'*)'*&*+.-,+$))('$,,,)(-,),%%*&&(()),*((+,'(%,)-&%&)*--,--'++*'11111.1210-+./2020+,-.&.-110--&')&$+//)1,11.102/.,-'10,20..,-),*,-/.+.-0&,1,1+/2+-0-21(/'(/+/+,0-1-/11+),0,)0+')++.$,0201,*1+',)+)*...,121.*)*,./+0)/-,0///,0-/))(-,*-,+,,,-/,1-%$'/,1,0002,.0/11,.'1+0-0001./,-1(..120/*0-,-1/1*,,*$)121'/0011,-0/010,-,$&)).*,,,(*'0..,0)0-.%,00-2210))0/,)0(0++.,'/)+0-))*(,1'-2))'&,11,./'/(#,0002./0-0'-11-.,+1+.,'/.(-/,01.1/)0+*+/*1*((-+*/101..11+11/,00&1-)00-*,)11112010)--..2011,$&)+&.-1..1021-.&)(),*,,*,,'(.$)*,/2.*0#*%,++/1-0*0-/1',**%(**+%#)&,%,-,).*/&)+&,-.,%./+,./&,((*0..,*+11/,*%&(/.,21*,*.)+*-+%(/*,*%')&&.,),*%&%)%-,)#%"&(.),+&/-0*#,0*%/,+)100--/-1-00-/0,.1')-')%&#$$&,..1&'(/.000(/++*//&.'')*.//+,(*,,+'-)-21&*0+,..-01111+).-10/1,-10--/-0-0/1*,0,+0'#)1&...0(/1*0,)(&%*+,0&,-0-110*.1+-,%0)/001,*/+$'*%($(,2+&+11-.*%.))0--,0/0,)+/10&'%+,/,0//,.,-/&+-/,2--$*+,*.01,0.*-*&,)&).,-,/.*+((((%%#+),+--1/0*1/./'/+*,+.0,,/-/*0%-,,',.+//(,0.0+*-/0.12/-%).-0+'-0,+*,&-/%,1+,+-)&.,)'+%),)*.111-/,-,+-*12.',/-0-.,-/*,+.,-,-*)+&*++/.211/+.1-.0-%++.$-*))*,-$+.+0(-*)%(1,/*1110+-,/21),-1),/').%/+(*)1/11.100+/01+101-*,1/1-01.&/'..1)2+*/(.*1--1,%*)/-01&0010102111-+/$'01.,00*.**,*-/.,)01-*+0,+-+*0/,*/+/&(&.-.21110(/,/**%+(/2.0*+211,10-...*)(-(+1/'&//)--),*++'//&/02/',*%%&+)%)/-&*()&+,&&..',++--/,*,0.,,,/1+/$-+*)/0*246103/04.41623/63*-),005.-210,1,/16663'31+,/3342031&/++36202)232066/3',.4,5213065605*5/52000--1-5/1*144,0123)40,643151/'.0.)/.0404-523-2+%-14..#+2/315621+,--66500040.0.-6.1-4.2/1$320+432*3156621,56*5)*)3350565.-4/150/1//*56114*064&32+(+1%'2/1465)23-01+/.416155400-%.*/3,+0501)143.&/.+.2-4//+,-$*4*2%-..235.*)30./64562661511+.,26)45.4/0565/05/625211252(-1,514000-3-'0110010(4025.63.5%0663404*3,.,3/1-10.)33.21''11*(3-4,202.(/(540500)11+461+0.622-'.6112&'.-2.&///3///34.,4.4-.0//12*.113%144.+202012541/1*434/5524..61201/-065(541,,41$/-13,22203*356+52654&/+031550.135.0.20.)-542**,232),/11512062,/3.1/.0.)%(0-/1+,/*,/4-.143+41/-*31365536611.-54(-./2/0*,0263/0,53-54(0+4252&01)$(0.3451,653322521-302/2266 @rCer/1583/1685_58_CCS ATGGGGCTGAGCCCAGGGAGGTGTGCTGAGGAGTGGAGGTGTATTTGGCCTGTAGAAGCAGTGGCCTTTGAGAACCATACTCTGCACCTTATATGGCTTGGGTGATCAAATAACTTATGGTCCAAATGCAAACACCTTGGAAAAAGGGAGCTTTAATGTAATTATGCCAAGGTGATAGGCATAAACTAAGACTATCCTGGACATAGGGCCACCTCTGTCTATAGCCATCTAAGATTTTCAACCTGCTGACTAAACAAACAAAACCCTCTTTCCTTTTAGAATATCCTGTATATGCTATTTCCCACCAGGGGCAGAGGCAGAGGCCACAGGAGATAGGCCGTGGTTCAGGTAGGAAATGCCCTTGGTCACCTCAGAACTCTAGATCTGGGGGAATAAACAAACCTTATTTATTACCCTACTCTCAAAGTTCTCTTCAATCTGGACTATTTGTGTTCCAAAGAAACATTTAATACTTTAGCTATTCAGCAATACTGAGAAAAAAAACATGAATACATTTATGACTTTGCCTTGACCATTGACTTTTCTAAAATGTGCTTCCTGTTCATTTCCCTTTTTTTATACAAAGAAAATAGGCCAAATTTCTCCTCTTAGGTCATTCCTTAACCTCTCAGAGAACCAGTTTCCCCATGAATTGGGAAATGCTCTCTTTACAGGCTGTTTGGATTGAATAAGATGCTGTTTATAAAATGTCTGTGCCAGGGCAAAGCATATGGTAGGTGCTTGGTGACAGCATGATCACCGTCACCACCAAGTCCAGTGTTGCTGAGATGTCACACTTGACACCTCTAAGGCTACCCTGACTGCCTGGAGTGGCACAGGGCCCTTCTGCAGTCTCTGGGTGCCTTTAGTTATAACCTCCTCTCTGGGTCAGACCATTAGCTTTCATGTCTGCTTCTAGCTACCACTATAGCCTCCCTTCCTTTTTTGGTTTCAAATCTGTCAAATCTGCCACAGCTGCCCTGCAACAAAAAAGATTCCTAAGCATGTCTAAGTCCTGTTTAAATGGGTTAGGGGTCCAAGCAAGCCCAGAGAAATCAAGTGCTTGGGTCTTTTGTACCTTTTTCATCTCTACGGCCCTGTTCTCTTCTAAAGGCCAGGCCCACAGGGGATACTGAGGAACCACCAGCCCCTTCAGGTGGCACAGCAGACCCTGAAGAGAACTGCTCTAACTTAAGAACCTTCTGACTTCACCATTTTTTCCAGTCTCTGGGTGTGGTTCTGATGAACCTTAAACTTGAAAGGGACAGCCAGAGGGAGGACAGTGTTGACCTGCATGTCATTGTGAGGTTATGACCTCTTTGCTATTACCACCTACTTACCCACCTGAGGCTCCTAGGAAACAATGAATGAAAGGTACAGAAAAAAGGAAGTAAACAGGGCTTTTTTCCCCCTTTTATGAAAAAAGTACACGAAAATGTTGAAACAATTCAAGTTTAATTTGTTGATATATGTCTGTACTTAGACAAACACTAAATTCTACAACATACGTAATGTCAACATGGGAAAAATACCAAGTTTGTCATTGCACATACCAATAAATAAATACATTTGCTCCAGAATACCAAAGAAGTTTATTCAAAAAGTCACTTAATAAAAGCACAGTTTT + *49::46778054/-47+7;9::::9:965.505:449164436917495:::239-5::9.:89-59-:788.:4659689'9759870203:63:;648059:755:/696:;::75801(46166598+,52(950(0574,::3,95:;.<25331';4038?:?;958=3;8=986:::,>::6988>;-5(624:8;69497;4782*57>76.5:85:1246<7134879&53)<84.-49=9660)26-11583$06.4469%=66:8&5;?9;69?:>8>7:4647659:3>?;8=;<=>>/>>;:<9>98/:8=7<98862817937;97>?59159<5-6<099.5>?<3=/>838==;8749=6544617>><=726:-5219:048;4;:;:>?<7;;233476877<:738&<=;933=6:98;8:=3;67=971;5:3)?8411=??505??>?<<:=:;6;;:>==16-09986<8>=6.388:854&37)20*55::>:0488965426;24.:4;4=74=854<:$94785(9=48.67<;:5;;?=::)95'688332(217;?:;><::6:<=>=9=96><6;953)8/5;=;:=<=7;4974*=<>:58/44.84?:;59<552=3;9079:7?844928396295351<365%48235+:;3<06626;465.8><090,10076*-26%%9<<96:?:<966/=;;:>>?;/78-;><=/;3679<>:;:8;>:=:7-18=<947?2:86+9683=;;,9?;9:124>=9655<<238<,,&/,33.53(/993062/4/204*/22+16+254159(67,58:5115638455/1,32/-0/+.8242576223/22257,6:0405420.11,1557:/4-711,3552+98168835167774::52328)447444457'7,72,+35.'2394415+7:7547521879601$)493532453)%455061123895:8:45439/331861)-+'4.+/3%2-//%0600,3-0(6;345:64:6/555.2-.45/6:.5-0-.$-04843554(81984323643996,1755,5701-97,212(+5,82+059;;:641559/26772:57;6.8:::4912.7-862)'.467(/-44&634,6547347656-8.+364+/)4%976283::1502,23)(2874%:569:75:46803679671955.,27(347189145/46432++-5.6;78727;78:6:73-/3:4554:::757:::6/,#////,-&)/*%015.38,352%964611430956*855(/76934.01421656.1-$/1163.'1345/402.52554455)406/2-04++363,11-/1/)5,13*.43')2045545(0$05.43564/322)-05,56/4)56434-)((+20231-65.2*555.233,1/*1+,$$-)+6556624102,,3-1364326666602+*,)**+-/210&112/3+563551544+54/52254,/*03222654000//1%.1*.++15/306556.05426/5540/+./1$.220,115-345-/30,554442( @rCer/1586/23_1745_CCS GGGACCCGCGCATCTGCAGCGCCCGCTGCTCGGCCCTGCATCCCACCTGGGCATCCTGCGCCCGGCCATGACGGCGCACTCATTCGCCCTCCCGGTCATCATCTTCACCACGTTCTGGGGCCTCATCGGCATCGCCGGGCCCTGGTTCGTGCCGAAGGGACCCAACCGCGGAGTGATCATCACCATGCTGGTCGCCACCGCCGTCTGCTGTTACCTCTTCTGGCTCATCGCCATCCTGGCACAGCTAAACCCCCTGTTCGGGCCCCAGCTGAAGAATGAGACCATCTGGTACGTGCGCTTCCTGTGGGAGTGACCTGCCTGCCTGACCCAGGTGCCCAGCTCTCAGAATGCCTGTGGCTCCACTGTCCCTGACAACCCCTTCGTCCGGACCTCCCCCACACAGCTGTGTCTGGTCTCCAGCTCCCTCCCGCTGGCACCCAGAGACCCGGACCTGCAGGGCCTGCCTGGTCCCTGGAAGTCTTCCCAGTCCTCCCAGCCAGCCTGGGCCCTGGGGAGCCCGGGGCACAGCAGTGGCCGAGGGGATGTCCTGCTCCAGTACCCGCACTGCTCTGGAGTTCGCCGTCTTTCCCAAGGAGATGCTGCTGGGAGCTGGTATGGGCGGGGTCCTTCCCTTTACGGATGGGGCAGATGCCAGGACTCAGCCCATCCTGAGGAGGACCCGTGTCCGCGTGGAGGGTGCTCCGGCCCAGGCCTGGGAGTCAGTGCCCCGTCAGCAGCTCTGCCACCATCCTGCTGGGAACTGGTGGGCCTCTATTGGGTTATAGGCAAGGCCTTTTTCTCTGGCATGGAATTGTTACTTTTCTGACACATCTAGATGTGAAATTTCTGAAAATGTTAAAGTAGAGAAACATTCACACACAAAAAGCAACATAGTCATGTGGGTCCAGATGGCCTCAGTCCTAGATATTGGCACCCTTTGCTGTGTCTCCTCAGAATATCCTGTTCCCCCTCCTCCACCCAGACCTCCCCTCAGCAGATGTCTTCCCTCCCGACCCCAGCCTGTCAGTGCAGGTTTGACACTGCCGCACTGCGCTGAGCACAGGGCAGGTTTGGGCCCTGACTTGGGCCTCAGGCTGCAGTGGGGGTGGATTTCAGAGCCTCTCATGGCAGCATCTAAGTGACCAGAGCTGGGATGAGAGAGGGGAAGGGGCAGTGGGAGTGGCGCTATGGGGCGGGCCAGCCCTGCTCCTGCACCAGCCCTGCCCTCTGCCCCCGGGCCCTGGGCTCTGTGCTAGGGATGGTGAAGAATGGGGGCGTGCCGGCCTGGCAGGAGTGGGAAGCAACACGCAGGGGTCCCGGGCCTCTCCAGCCTTGCCCTCATGCTTACCCAAGCTCCCGTGTGGTTAGTGGTTAGCACAGAGCTCACCCGCCTTGCCTGGCTCCCAGCTGAGGGTCTGTCCCCACCGGTGCTCCGGGGAGAAACGCCAGCCTTGCTTCTGTATGGACTGCTGATCTGGCCTGCTGTCCTGTTCAGTGGGCATTGTCTTTCGAGCAGCAGGAGAATAGGATGCCTCTCACATGCCAGTTCCCAGCTGGCCAGCTGCTCAGGGCTCAGGCTGGGGCCTCCCATTGACATCCTCCCCCAACACTCCCTCTCCGGGCCTCTGTTGCCCCTCCTGTTGGGTGAGGGTGTGAGTGTGACTTGTGTTGAAAACCTGGTTCATATCTAATAAATAATGGTGATGAAAAGATTACTGTTGG + /-.:<:5CB>7AA;>DCJIHI2GHF:?FBAB%;$=)0?C9B2GIE6;>6GA@F>0C<5B9+HH:A;EDI4FHG/7HCJ81AE@ICFIH0C4H-?5C@C>.CCDA>B4>6HE?A@=3>1@CJGG=KF5F+HF@,DA8A6EEC6H9;:D9BCGAGEHF:<-D:GH;H?4E>??G>DBIAJ;FD7H+ECGAH@4I:EGFGFE/KI'JG>DCIBCG2?E&CCAH@J>AFDI?E@:E329HCHCB=C5FFFA?FAI<@E%>==@GI>AFF=4=9HIE@@EGFGGJI>D/@F;(DHIB94?AIHECGEDHG;@9<'97?ADIB:GAHJ<7EB:4EFBIEBI?B5I@@E@7DHKKGIFHIJFGF0JH7HEG@I:>KI=GHIEK5ECE@+C%BIGKF7CD7H7HK:J4AGB7HG@>@??(@H808>,8=1?0D?D>@BJKJK@J>HI1IKIJGHAG4GGGBAGGEH?GC>FGFC:??7CKF5CIFEBFI9@??+D*)FCGAE>KIIFKGKJ=KIFD8FKCAB)C88<3?;FHD>IIFEBBKIBF@@7>FHJJHKJ@DEC@JD>AJ;GAAIK+I)KI5JHDG6CIAJ?CDK&EDAHB=D<=KIJIDK>JAKJAJIH8CE?6ID=GDI>?HJIJKIGD9?FG2EEDEI2IFE/=*J0DIG=A4C;6DBDJDKFIJJIFI.FC:9AA5EH=9C4I=E@D>-GHD>CHH<9@IEGHH;@CEHBDKKJKKKFKGG7D84JEJKCKIGG8@HKBJJG;JC@F=FBG8F'JHAJ96H4(C>08<:4:3I@4GKKCCFHJIE@JFH=:H=JHG(HD;B7JFB5G/K8DF>KIK?IG:C-E=?36GA%1(<.2B>@F:CC@GGEJDCC0KKKDIG;KC4EDBJFAFJ;>G)@A2J?GE:J?DHIGJI*?0AH?3HG5JFBFJHHCG?DHBDJAK?4H@@DEI@B4DHF?CBE?FJJ:IBGIG=6E)=#/,-6?2==G??IJ?KF:?>;DBIEE=D:GFJFBKJKKJDKIJGDGJDKGI8KIJJBEI)JIKHDFK(J?F9>99I6E=13AFAHAF9:HHGHJKGAG5CJIHKGKF=JJ@EIE9DBF=5E'@=KKEC@CC-GGDC@@:D8;>IB:'KKA$.B;HAIBD:@?E8HHCBBD/G<53:8@C?H69IC?2GHCHIF?;4=G3FEFCD3EGC<=DIAD;IHJE@@H?BD@CGD;<=<=>@FBD=ID@ABI@4@;;C?@8:4BJ/5CCBHCH5=6=GBGIE7@=HFHF5DH;(EH:5@9*BE?GJKIGEJ@CC=>B7=,1<7HKGK@/18:C9/EB5746=<4>%<758B3BA;;*7;=@F>?=<>B?AFBA:2=CD@G?/<=D?D?F??=@GE9IB?8<50>.4 @rCer/1589/1575_54_CCS ATGGGGCGCGACAGCCGATGGCCGCAGCCCGCGCAGTTCTCGCCTTTCTCGTTGGGTTCACCGTTGGGGAAGGATCGCGCGCAGAGCACAGCGCGAGCCCGGGAGGAAAGGACTCGGCTTCTCCAGATGCTTGGCGACAAAGGCAGGAGCGGAGGTGGCGGAGGAAGACCTCGCTGCACGCTGGGGCCACATGCGGCGACCCGCAGGCTACGCGGCACCCCGGCGGCGCCCCTGATCCTCGCCGCCAGCTGAGAGGGGCCGCGTCTCCGCCCACAGCTCTGCAGCTGGAGAGGCGCGCTGGGGTCCGACTCCACGCGAGCAACCTGACGCGCGCCGAGCCTGACACGTCCCGACCGAAGACGCCCGGATGCCTGGCGACCACCGCCTTGCCACCCGCTCCTCAACTGGTCCGCCCGCAGCCCTGCTGGCCTCCCAGGAAGCGGATCCCGCCGCCCACTCCCCGCTCCCCGCCCCGCCCCCGCCGCGTACCTGAGGCTCCAGCCGAGACGAGCTCCTGGGCACTCGCGGCGCTCGGTGACATCAGAGCCCCGGGCTCCGACTTCGACCCCACCTCCAGGCTCCGGCTGCGGCCGGAGGGAGGCGCCACGTCCGGCTGAGGGGTGGAGCCACCGCCTCTCGGTAGCGTCCGCGGGCCGGCCCAGTTCCAGGCCTGAGAAGTGGACAGTGCGTTCCCGCGCGGGTGGCCTCTTGCCCTAGGCCGGAGAAACCTGAGCGAGGGTTGGGAGGGCGACTACCGCGACCGCCCACCGGCCTCCAGCGCATCCTCAGCACCGTGATGCTGAGGGGCCGGGTCCCTGGGGGCCTGACACCTCCCTCGGTAGGGAGGTCCGGGGCGGGCCCTCAGTTGCCTGACTGCTACCCGCTTTCCTCTCCGAGCCAGCCAAGAAACAGAGCTGCCAGGGCCTCGTGCCTCCCACCTGCTGAGTAACTCGCCCTTGATCAACTCTTCCCCAGACCCCCATTTCCAAAACGCTTCCAGCTCTTTGACTCCCACCATGGACTCTTGTGTCCTGTTCCTGTCCCATTTCTTTCCATTTCTCCCACTACCCCGCATGGTCGGGCCTCCAGCCTGCTACAGGGTTGGGGTGGGGCGGAGCACGGGAAGGCCCTGTACTTGTGTGCACCTTAGCTGTCTGAGTGGGTCCTTAGGAGCTGGACATATGCATACCCACTAAGGCTGGACGCTGGCGCTCGAGGCCTCACCTTCCAGGATCTCCATTTTCCAAAGAACTCTCTGCCTGCACCTGCCACTGAGCTCTCCTTGCTGTGTCCTCAGGCTCCCCGCTGCTCCTACTTTCCAAACTCTGTCCTATGAATACCACTCTGCCAAGAAATGCTCCGTTCCTGAGAGGGGCTGGGGGCCCTTTGCTGAGCCTCTCCGGCTCTCAGGTCTCTGCCTTTGTCCTCCGCTGCCCTCCCCCTTCCACAGGATCAGCAGGGCTGGGCTCAGAGGCTGTGTCCTCCCATGGTAGTATCCTTGGCAAATAAAGGTTTATTGGT + 6B==B(ADEJ9J7KJGDFF/=HJICEI,188%(*EJ:ADDFIA9F,J;FIJ7FH6FDC'@9IDHGHJ>HIJGGIHAGIHJJIKIKFDGG6IE3:A(IG*B8IFAFE;;C>??I9C;IHD=F1I<>A=HDDFE6GGG6G9B?9@A*ECFK;IA8AF&H=5E>CBDFF5FFHFH0JG>KIKK?JGB9??B;EJA+@><9CHIHD:=D'BJHJABEEB>ABE5IKFH5AEHBGCD/>J5GG>6IKFFAJIJB3J+BCIJJGF+CFGFCAG?CJ>I7KJEEHB6?GAICIJK;KIJ?AC+=;?+957;EI4HF7DF6<&6DH/:B%*0EJJ-EDGJ2?@*E?B,>>><IJKKKKKIJBH>E@1EI(CFKFJKKJJJKFGHK:HC2@FHIB-KKKDI5KDJCK.KG11ACH&@1&F>J:JJ@DG.JBJJHEJHJ%II8KJKFFJCJE:F;GAI-H<=A@=='8HCK)KAK9KK>GDE5KDFK7I9FKJEKH@>K:EHF7@JJ?K7F=2HHF>D@(DD'J>JKK@IKI5JFK?A%F<8@GK6EJJ-:5JE8GJK-GHGFFGE;BJDJG->GJ-KK>H:?)&B1JCEKCGEKDHD?@;@C&CIKHEHG9JII@C/=,GK0JKK:GG>FE%J3JJFA@I/?DE*IFF*FIKG>GJ7HD6HKK-JKK3KK0KKCIJ@JK@CI8CJJ@J;FE?C>IH;BAKIK>B?H7K*DIH8K=KJK&B8FDGGGCE-IIJ5KFJIJKKK0JKK/HG1JKGIKKGGJ;BJC>DF&@AKGH;H2JHIJ;@HJ1KDGJJIG0JKK/K/KCG,KJIF4@5JD@HFKK:JJKJHE+AK;?GJBGAD2HCHF>DK?GIKAK?GIGID&CFI?FKKEKCKKKIHFEI.D@CED3=/IH@BJ5;9F8'I$>C6HFH8JG?EE&IKJ?IC?H;AF+IEJJH9KKKHJGFIJIDBK'JHGK@KEIGKEHJIG>JFKKJEJKJE>?$9B7H;JHKIFK*JJJII@IKKKCG*FJ,I>IK8KD:KK8IGKJKJJKFDAHEGI@BIK+GJKKKJ%GK$GK=IJIKGC?8@<@6:A:A@AA:CC9@A?=582<=BBA>AC7<4>0:<66@;4?@C@>@?;4AAAA>A;BAAC@:A@A@>9@A<06.7::7=6===>=6.=<;<86=:<=9==?78?:=99=.394.6<94?36==02;:969;3<4==:8?=6=<19;>8=<=>9<66;/)<><;<;4:=;:=?9=:?>>;;>69?<=8=9945>;<:=7<<9:?4/;6/8:>9:;;>>:;:55;:;99:::;/:47;773=8??;7=>:6;8==:;>:53=;2<=<:98=5;<9=3<8=:62>>;8-;:7:>>;.<=:0:9=0<:/<;:=1;9?:;1==8470>7847?3?9;:;&3:889?67=<>=;71:8>259,8439>>7<826-49:;<88<=?=:<=784:=9><9><69<6:=66379-079;4:8$-41<=>>6<>;=96:<8567=?===<<:<637=;==>?><=5?=.36;=??>8<=<77=.:99<<>>=?<<;59:>=9>97=89<1(8;;3>8:>==>50==?=<=2=?9>5=:=9:===8<=6;>97==<>=>:6:-:9==>=?=4<<>5>4(<8=8=/<853;99;997;3=:=<9=98677<=>?<3=:;927:7=;<8?97?><>7>9<:6/::=99738=:::<=>68=8>9:=;>?==7=496::=?>?6>;;>;4<5-56.9736<=:>>36>;:5-930359;?;?>=>.;8:=7:>;<9>67==6<=>:7;88=<8;45=;:=>=6=<>><,8<99=>2?2<0<><+63;>?9=9><><:89>13)0415>=>7;687<=><>::3=>4:=';7227::?:=>==::6;6:;<88>.><<==:7;9797::4:?/;6=9:46=;7=7*79?==8=:8:':9517<=>:9?=9<6>>28=<:>3;;6*8<62698;3><=6===<<<==>=7907285>2=<7;>299:>3;=?9;;<>:94:>:7>=:&:8=;<737.=746;=>8;<=:>8;/065059>;5>;?5;=<>=;9;?=7<=:<8:?8>:=>:>;9<:;9=/:99?9896:=72>;:=>778?=>;=>=;887=:9=?6:;>;987:.537:49=98688>37:97=8=794767=4;=88<+:<;>:9>6=4999;:7==9:?=8-:697>;68:;<2219;>3:<4==;:>>:?9=<;8<8724+;5=2>/3=4=:8;:8>=;:/==;295,87;7=8;?:?=>7<2<<>9;0968>7=,69>9<<<.=>?>:>;=<:8::;89;=>3::79=:<<;<72;850<+>>:?==>==9<;:8.:>-7=<<4>=8>:=:=>79=1*=<99:?=89>9=+648=3=>06714875.8:>:?>==9:9>>6;:77;>==?9>>79===39<;;;9>>06:;99>3;<?==>8>=56>8'<::<>;6=:99<579=?;=>>588:=;><5=4:9>;9<>5;49=>2<<<6:82-131330/)4:99;>::(3/=8===>6:<58:=?89<<3:?::(79;?=79:9??=:8=?><=493+6<:;><;>;>;:8;=<8<9<59=:=<7=<9;:258*9<86;7;<3=8=><=:4;;84:94=59<;9733:2=9:>>4:;9?9?>0:<;<<63???;>;;9=9?8?:=7=6??=?:=<637?<0=6(8:<73=??<;:?7<<=?9<3:;<;=2;?<99=8:>:;>;4#=<96:;<96?;=<9;79==8087+994?>>;6<::<4=>>:<98<<=?86====;<8<8:6>>9=?:>=7:7=927>:=<<<6=<8><469>>>>=<=;9?;::<8><4;9=>>3;;=3=99560;3;6<===4;;;:2==?;96=:=9.2;1;9<2;:9:7:<>8;:<<4?=<567:<><:<<==<<=8>=?:-<58=8;7<9>9?9+58::9(976?>>97==>9:::9?96=>4719<9>=7>==??9=><;9<88<:68<=8:>>9=<:?=>:><><6:98>7=7=:>?;2<:28;>6=>><99:=68<699=6#:98:>>2=>:3><658;:,95:6768/457:>8*8;<9425><8=;:><:6<8:9:=9631(/,7>==:=29=<6>;>9+3<>><=;5=89:<=82<>97>;887-:6598.5728:?5::><5;487<;666:?;<9?>:708::=<:67?6<.;5:=<7<<===69?9=82=79?=2:8=<;756079<:4:68312:>+::;:=><)<;=::+<:;;<:9=>:.979:;;?=;;4=:18==>6<<<=>?:<>?9=9=:=8977=8>=9?<:998?318;==?>?9=?><>7?;?>:<;72.55/812;9*:<>:<::<>=,99;=7<979;5;:>79;<2;;9=>:2;==7=??>9<95<>4<0<<7,:8<9:9>?=1:72=99=;>:=>>9=323<85:>;?9;;:===7<<9=>1<>=69=<276075:6<;<87=:9<6838/9:2><<2<9<9??>=-===;3819210473*773.279:977855;87:76269402299819:89559180876848:887;8:78:19:8/51,888373589499995535869;997;68,9808:28::;6464159345990,:88:948438;;43,:55.6:8:63:73+95-93/3498:2;:295618524096:98:27.78:7579:80::75957%45145/6990;226489;58855*551:8926+10697;:;6/5926/672868607318/45971:4947:95744913681956:1-4;.98:6897,965-2-8::977:9:8:446:4:95-53;;38289: @rCer/1593/0_1944_CCS ATCTTTCCACGAACTGCTCACCCCTCCCACCCCCGGGACAAAGGGCGGGGGCGGCGCATCCCCCACGGCGTGACCTTTCCCCGTACTGCGCACGCGCCCAGCCCCCACCACCGGGGGAGGTCCGCAAACGCCCACAGCGAGTGCGGGGGAAGGAGGTGTGGGGGCCCCGGAGGTAGGGACGGCAGCGCGCACGGGGCTGGAACCTCCTCCTACCCTGGGAAGTTGGGGGCAGTTTCCCTCTGCACCTTGCCTCTACCTTAGGCTCGGACGGTGGCCCGCGATGAGAGTCCTTCCCCTTCAGGCCAGGTGTCACCTGTCAGGCGACCCTTGGGGCACCCAGCAATTTAAGGCTTCAGCTTCCTTTTCTTCGATACCCAGGAGGCCCAACGTCCCCAGCTCACTTCTCCCCTAGGACCTCGGTGGCTGGGCCCCCTGTCCCTGACTCTGGGAACCCAGGAGTTTGAAGCCCAGGCGTTGTTTGCCTCAGTCCTGGGGTCTGGGCTTCCTCCTCCCTCAGACCAAGTGTCCAGCCAGAAGGTCCTTCCTGTCTCACTTCACCTCCCCAGGATGGACCCTCGAGGTCCATCCGGGCGTCCCATCCATTTGTGGCTGCTGTTTCTGATCCCAGATTGCCCCTGAGGCCCTCGGCTGCTGGGAGTCCGCAGGAAGCCACGCCATGAATGACCGGAGCAGCGGAGGCGAAACAATGAAGGACGAATGAGAACCTTCGAGATCTCCATCCCCTTCGGACAGGCGCCCACCTAGAACTCACAGATCTTTTACAGTCTGAGCCCCTCTCGGGAAACTTCGAGGAAGCCTCCGGAGGCTGCGTCCCCGCCCTGGCTTGATGAACAGCGTCAAAGGCCCAGCTGCACATGGCTCTGGAGAGGAACTCCTGGCTGCAGAAGCGCATCGAGGACCTGGAGGAAGAGAGGGACTTCCTGCGGTGCCAGCTGGACAAATTCATCTCTTCTGCTCGGATGGAGGCAGAGGACCACTGCCGGATGAAGCCTGGGCCCAGGCGGATGGAGGGGGACAGCCGGGGTGGGGCTGGGGGCGAGGCCTCGGACCCTGAGTCAGCAGCCTCCTCCCTCAGTGGAGCCTCCGAAGAAGGCAGCGCCAGCGAGAGGAGGCGGCAGAAGCAGAGGGGAGGTGCTAGTCGGAGGCGCTTTGGGAAGCCCAAGGCCCGGGAGAGGCAGGCGAGTGAAGGACGCCGACGGGGTCCTCTGCCGGTACAAGAAGATCCTGGGCACCTTCCAGAAGCTCAAGAGCATGTCGCGGGCCTTCGAGCACCACCGCGTGGACAGGAACACCGTGGCGCTGACCACGCCCATCGCCGAGCTGCTCATTGTGGCCCCCGAGAAGCTGGCCGAGGTGGGCGAGTTCGACCCCTCCAAGGAGCGCCTGCTCGAGTACTCCCGTCGCTGCTTTCTGGCCCTGGACGACGAGACGCTCAAGAAGGTGCAGGCGCTCAAGAAGAGCAAGCTGCTGCTGCCCATCACTACCGCTTCAAGCGGTGATCGCACACGCCTCCGCGCCTCCGCCGGGCCTTCCTCCCCCGCCGACCCCGGCCTCCCCAGGCCCCCGGTGGATGACCTGCGCCTCTCCCTGCCGCGCCCCTGCCCTCCTCCTCACTCCCTGGGTTGGGGCTCCCTTAGCCCGGCCCCCAAGAGCGACGGCCCAGGGCCGGCCGCAGCCCTTCCCGAACGCCGGCATCCCCTTCCGCTTGGGCTGCCCAGCCCTGTCCTCGCCGGACCCCTTCCTCCTGGAAATCAACCAGGCAGGAGGGTGCCGCCCCCCTCTCGGGGTGGGACTGTATAGACCCCGTCTCCGCCCCAGCCCCGCGGAGGAGCTGCCCACCTGATTCCCGGACAGACCTCCCCAACTCCGCGCGAGACAGAGAATTATTCAGAGAATTTAAATTAAAAAACGACGTGAAAATTT 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@rCer/1594/1786_60_CCS ATGGGGAAGCGCAGACCTGGCCCTCGCAGCCTTTTGCATTTTATGCCGGAACAGCGGCCAGCGCTGAGCAGGTTTTAAGATTTGTTTCACGAGGAGCCCTGGCGGTAGCGAGCTGAGCCGTGTGGCCCGGGAGATGGTGGCGGGAGGAGGATGCAGGCGGGTGCGGCGGTCGGGCCGGGCATGAGGGGAAGGTGTCAGGGAGGGGTGACCACCGTGCTTCTGGCATGAGGAACTGAGAGGCCGGAGATGCCATTTGTCAGACTGGACGACGGAGGAGGAGCGAGTGGAGATTCTTTCCACCATGGCCAGACGCCCCCGGAGCAGCAGGGCCTGGCACTTCGTCCTGAGTGCAGCCCGCCGAGACGCAGATGCCCGGGCTGTGGCTCTAGCAGGCTCCACTAACTGGGGCTACGACTCTGATGGGCAGCACAGCGACTCGGACTCCGACCCCGAGTACTCTGCGCTGCCGCCATCCATCCCCAGTGCGGTGCCTGTGACCGGCGAGTCCTTCTGTGACTGTGCCGGGCAGAGCGAGGCCTCCTTCTGTAGCAACCTGCACTCGGCCCACCGGGGCAAGGACTGTCGATGCGGAGAGGAAGACGAGTATTTCGACTGGGTCTGGGATGACTTGAATAAGTCGTCAGCCACCCTGCTGAGCTGTGACAACCGCAAGGTCAGCTTCCACATGGAGTACAGCTGTGGCACAGCGGCCATCCGGGGCACCAAGGAGCTGGGGGAGGGCCAGCACTTCTGGGAGATCAAGATGACCTCGCCCGTCTACGGCACCGACATGATGGTAGGCATCGGGACATCGGATGTCGACCTGGACAAATACCGCCACACGTTCTGCAGCCTGCTGGGCAGGGATGAGGACAGCTGGGGCCTCTCCTACACGGGCCTCCTCCACCACAAGGGAGACAAGACCAGCTTCTCGTCGCGGTTCGGCCAGGGCTCCATCATCGGTGTGCACCTGGACACCTGGCACGGCACGCTCACCTTCTTCAAGAACAGGAAGTGCATAGGCGTGGCAGCCACCAAGCTGCAGAACAAGAGGTTCTACCCGATGGTGTGCTCCACGGCAGCCCGAAGCAGCATGAAGGTTACCCGTTCCTGCGCCAGCGCCACGTCCCTCCAGTACCTCTGCTGCCACCGCCTGCGCCAGCTGCGGCCAGACTCGGGGGACACGCTGGAGGGCCTGCCCCTGCCGCCAGGCCTCAAGCAGGTGCTACACAACAAGCTGGGCTGGGTCCTGAGCATGAGTTGCAGCCGACGCAAGGCCCAGTGTCTGATCCCCAGGCAGCGACCTCGGCCCACCCCAGCAGTCGCGAGCCCCGGCCCTGCCAGAGGAAGCGCTGCCGCAGGACCTAACTTCCCAGTGGAAACTGTCTTCTGGGCTGGGACGGCCGTTTCCTGTCCCTTTCCTCCAGCTACACTCCAGGGCGGAGTTGGATGAGCCCGTCCGGAGGGAGCTATCTCTTGCCTCCTGAGGCTGGGACAGTCCTTTCTGTGGAGGCTCTAGGGACCCTCTGCTGCTGTCCTGGGTGGGGAAGCGGCTGCCCCGAGCCCCAGGTCTTGTGGGAGGCTGTGAGGAGGGCCTGGCTGGAGCCCGCCGTTGCTCTTCCCACAGGGACTTGGATTTTCCTAACTTGCTCTGCATGCTGTCGGCGGCTGCCCCGCCGTCGTAGACTTAAGTGACTGCAATAAATGTAGAGTTGATGTCTAACAC 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@rCer/1595/25_1782_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCTCCATCGTGGGGCGCCCAGGCACCAGGGCGTGATGGTGGCATGGGTCAGAGGATTCATATGTGGGCGACGAGGCCAGAGCAAGAGAGGCATTCTCACCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGCGACATGGAGAAGATCTGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCTGAGGAGCACCCGTGCTGCTGACCGAGGCCCCCCTGAACCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGTCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAATGCTTCTAGGCGGACTGTGACTTGTTGCGTTACACCCTTTCTTGACAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTGTTTTTTTTGTTTGTTTTGGTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTAATAGTCATTCCAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCACTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGTGATAGCATTGCTTCGTGTAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAGTGCACACC 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@rCer/1599/2428_59_CCS ATGGGGGGGGCGACAAGATGGCGGCTGCGGGGTCGGCTACGCGGCGCGTGGGCTTCGTGGGCGCGGGCCGCATGGCGGGGGCCATCGCGCAGGGCCTCATCAGAGCAGGGAAAGTGGAAGCTCAGCACATAGTGGCCAGTGCACCAACAGACAGGAACTTATGTCACTTTCAAGCTCTGGGTTGCCAGACCACCCACTCCAACCAGGAGGTGCTGCAGAGCTGCCTGCTCGTCATCTTTGCCACCAAGCCCCACATCCTGCCAGCTGTCGTGGCAGAGGTGGCTCCTGTGGTCACTGCTGAACACATCTTGGTGTCCGTGGCTGCTGGGGTGTCTCTGAGCACCCTGGAGGAGCTGCTGCCCCCAAACACACGGGTGCTGCGGGTCTTGCCCAACCTGCCCTGTGTGGTCCAGGAAGGGGCCATAGTGATGGCGCGGGGCCGCCACGTGGGGAGCAGCGAGACCAAGCTCCTGCAGCATCTGCTGGAGGCCTGTGGGCGGTGTGAGGAGGTGCCTGAAGCCTACGTCGACATCCACACTGGCCTCAGTGGCAGTGGCGTGGCCTTCGTGTGTGCATTCTCTGAGGCCCTGGCCGAAGGCGCCGTCAAGATGGGCATGCCCAGCAGCCTGGCCCACCGCATCGCTGCCCAGACCCTGCTGGGGACAGCCAAGATGCTGCTGCACGAGGGCCAACACCCAGCCCAGCTGCGCTCAGATGTGTGCACCCCGGGTGGCACCACCATCTACGGGCTCCATGCCCTGGAGCAGGGCGGGCTGCGAGCAGCCACCATGAGCGCTGTGGAGGCCGCCACCTGCCGGGCCAGGGAGCTCAGCAGAAAGTAGGCTGGGTTCTGGCCATCCTTGCCTGCCTTCGTGCCCCCACCTCTCCCTGTGCCCCTTCCCCTGAGGACTGTGGCTCCCTCCCTCCTGCACGAGGGTCTCCTATCACTCCTTCTGCCCCCGCACAGGGAAATGCAGGGGGCAGGACTTGAGAGGTTCCAGCAGGCAGGGGAGTCCTGACTAGTGGGGACACTCCTCCTTCCCTGGTAAGCAGAGGGCACCGTGGTGGTTGCCCTGCCCCTTGCTGCAGTGAGCCCTCCTCGCTGCAACATACATTCTGAGGGGCCCAAGAGATGGCATCTTGGTCAGTTGCCCACATGGTTGGGCTGTTGGTCGAGGCCATGAACAGAACTTATTGGTAACAGGCACGGCTGGCCCAGTGCCTGATCTGGAACCGGGGCTTGCCTTTGGCTTTCCAGGTGGCTCCATGCAGCTACAGCCAGGCCAGCTGCCTCATCTCAGCTCTAGGGGGCACGAGCCATATGGGGTCTACACAAGAGACCCTCTCCCCTACAGTAAAGCCAGGGGCCCTGGCCTGCTGTGGGTGGGGCCCCCACGGGGAGCTGGAGCCTGCCCTGCAGCCCAGAGAAGCGGGTGCCTGTGGTGGGTGTGCTCGTCCTCTGCTAAAGAGGAGGAACTGCTGGGCCAGGTCTTCAGCAGTGCTGGGGTGGCACCAGGCGGGCAGTGGTAGGTGGGGCAGCTTGAGGTCTGAGAGGGTGGCCCTGGCCAGCCAGGACAAATGCAGACCCCTGGCTTTAGTTGGGATACAGTCTCCCTCTTTCCTCCTGATCCTAAGCTCCTGACAAGTGGCCAGGTGCCTCTGGGCCCTCCTGCCCCTCACCTAGGTCAGGGGTCCTGGAATGCCCCGTGGCTCTGGCACCACCACACTGGCCTCTGACGGTAGGACTTGTCCCCTTCACATGTCCCTAAAAGGCAGCAAGTCAGGAAAGCCAGGACTTGGGGGAGAAGCAAAGCTCCAGGATTGAAGGCTAGGGTTCTAGGGCCTTTGGGTGGGGAGGGCCCAGGCCAGGCAGTCTTAGCTCCATCCCCTGCCCCACAAGATTCACCTGGGCCTCCAGTCCCATGCTGGCCCCAACTGCTGCAGCGCTCAGCTTCCACCCAGCAGCCTCTGGAGGAAGGCGGGGAGCATGCCCTCAGCGAGGCTGGGCAGCGGGTTCTGCTGTGCCATCTCCCTGTGTGCCTGGGCAGATCAATCCCCCAGTGCAAAACAGGTCTAAGGGCACCTGCAGGACAGCAGCACGCTCCATCCTTCATGCTCAGCTGCCTCTGTGGCCACAGACTTCTGCCCGCCACCTGCTCTCTCTTACTCCTCCTAGCCTAGCCCATCCGTAAGCTCCCTCCCCCGCCTGGTTCCCGGGGCAGGCTGACTCAGTCGACTGCTTGGTCCAAGCCTGGCCCTGGCACTTGTCAGGGTCAGCCTAAGGAGATGGGAATAAAGATGCCGGAGAGCACCAGGTGAGCTTATGTTTCACCAGAGGTGAATAAAACCAAGTTCCGGGCCAGGCCCAG 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@rCer/1602/1666_52_CCS CCTCGCTTGATACCACTGCTTCGGCCTCCGGGCCTTGCGGGACTCACTCCTTCAGCGTCGCTACCCCCAGCTCAGCTCTTACTGCGGCCGCTCCGACGGCGGTCCACCTGTCAGGACTATGCGGCGCAAATCTCCTTCGCCAAAAGCGGGCGCGCCACCGGGCGCATCGTGGCGGTCATTGCGCAGTGTGGACGTCCAGTTTGATGAGGACTACCACCAATTCTAATGCCCTGGAAGTGCAAGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAAGCACAGTAAGGACTATGCTATGGATGGTACGGAAGGCTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTGGTCCTGAGACTTGGGCAGAATCATGATGTATGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTGCCATTCATGCTGAGGCTCAAGTTCATGGAAATGATGTTGGCAGGAATTCTGGTGACTGGATCAAGGTTGTGGATCTGCTACTCCCTATGCCAAGGTGGCAAAATTGGCTTTTGTGGTGCCGGAGTTGGCAAGACTGTACTGATCATGGTAATCAACAATGTCGCCAAAGCCATGGTGTTACCTTGGTTGCGGTGTTGGTGAGACCCGTGAGGCAATGATTTATACCATGAAATGATGAATCTGGTGTTATCAACTTAAAGATGCACTCTAAGTAGCGCTGGTATATGTCAATGAATGACCACCTGGTGCTCGTGCCCGGGTAGCTCTTACTGGACTGACTGTGGCTGAATACTTCAGGACCAAGAGGTCAATGTACTGCTATTTATTGATAATATCTTTCGCTCACCCAGGCTGGTTCAGAGGTTCTGTATATGGGCAGAATCCTTCTGCGTGGCTATCAGCTACCCTCGCCACTGACATGGTACTATGCAGAAAGAATTACCACTACCAAGAAGGATCTATCACCTCTGTACAGCTATCTATGTGCTGCTGATGACTGACTGACCCTGCTCCTGCTACTACGTTGCCCATTTTGGATGCTACCACTGTACTGTCACGTGCCATTGCTGACTGGGCATCTACCAGCTGTGGATCTCTAGACTCCACTCTCGCATCATGGATCCCAACATTGGTTGGCAGTGAGCATTACGATGTTGCCGGGGTGCAAAAAATCCTGCAGGACTACAAATCCTCCAGGATATCTTCCATCCGGTATGGATGAACTTCTGAGAGACAAGTTGACTGTGTCCCGTGCACGGAAATACAGCGTTTTTGTCTCAGCCATTCCAGGTTGCTGAGGTTCACAGTCATATGGGAAGCTGGTACCCTGAAGGAGACCATCAAAGGATTCCAGCAGATTTGGCAGGTGAATATGACATCTCCCAGAACAGGCCTTCTATATGGTGGACCCATTGAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATGCTCGTGAGGGGTCCTTGTCCTCTGTACTGTCCCTCTCCTTGCCTAACCCAAAAAGCTTCATTTATCGTGTTGGCTGCACAAGAGCTTGATTGAGATATATTCTGTCTGAACGTATTAAGGTTTCCAATAAATGTACACCC 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@rCer/1603/30_2506_CCS GAGCCCGCGGGAGGGAGGAGAGAAGCGCAGCGTTTCCGCGGTTGGCTACTCAGTGTCTTGGTCTCAAGTTGCCTCATTGCGGCTGGCGTTCCCAATACAGACGCATCTTTTCTTTTTTAATACTTCCTAAGAAACAGAATAACCTTCAAGCTGGCGGGAGCAATGGTTCACATAAAGAAAGGCGAGCTGACCCAGGAGGAGAAGGAGCTGCTGGAAGTCATCGGGAAAGGTACTGTCCAAGAAGCTGGAACATTATTATCCAGCAAGAATGTTCGTGTCAACTGTTTGGATGAGAATGGAATGACTCCTCTAATGCATGCAGCATATAAAGGAAAACTTGATATGTGCAAATTACTACTGCGACATGGAGCCGATGTAAATTGCCATCAGCATGAACATGGATACACAGCCCTAATGTTTGCTGCACTTTCTGGTAATAAAGACATCACGTGGGTAATGTTGGAAGCTGGTGCTGAGACAGATGTTGTCAACTCTGTGGGAAGAACAGCAGCTCAGATGGCAGCCTTTGTGGGTCAACATGATTGTGTGACCATAATCAACAATTTCTTTCCTCGAGAGAGACTGGATTATTACACTAAGCCCCAGGGACTGGATAAAGAGCCAAAACTGCCCCCAAAGTTGGCAGGCCCACTGCACAAAAATCATCACCACAACGAATCTTCATCCTGTCAAGATCGTGATGCTTGTAAATGAGAATCCTCTGCTGACAGAAGCAGCAGCCCTGAATAAATGCTACAGAGTGATGGATTTGATTTGTGAGAAATGTATGAAGCAAAGAGACATGAATGAAGTATTGGCTATGAAAATGCATTACATAAGCTGTATCTTTCAGAAATGCATTAACTTCTTGAAAGATGGAGAGAATAAACTGGACACCTTGATCAAAAGCTTGTTAAAAGGCCGAGCTTCTGATGGCTTTCCAGTGTATCAAGAAAAGATCATCAGAGAAAGTATCAGAAAATTTCCTTACTGCGAAGCTACACTCCTCCAGCAGCTGGTTCGAAGCATTGCTCCTGTTGAAATTGGTTCTGATCCCACTGCATTCTCCGTCCTTACCCAAGCCATCACTGGCCAGGTGGGTTTTGTGGATGTGGAGTTTTGCACTACCTGTGGAGAAAAGGGAGCAAGTAAAAGATGTTCAGTTTGCAAAATGGTGATATATTGTGATCAAGCCTGCCAGAAGACACACTGGTTTACTCATAAGAAAATCTGTAAGAATCTGAAGGACATTTACGAAAAGCAACAATTGGAGGCTGCCAAAGAAAAGAGACAAGAGGAAAACCACGGCAAACTTGATGTCAATTCTAACTGTGTTAATGAAGAGCAACCAGAGGCTGAAGTGGGTATCTCCCAAAAAGATTCCAATCCTGAAGATTCCAGGGAAGGAAAGAAAGAATCTCTTGAAAGTGAAGCTGAGTTGGAAGGCTTACAGGATGCTCCTGCAGGGCCACAGGTGTCAGAGGAGTAAAAGCCAGAGCAAGTGCCAGTGGGGATGGTCCTCACCCTGCAAAAAAGCTGGAAAACTCATGGGAATGCATTGTCCTCGCCTCGTTTATACCTGCATGGCACCATGGCAGGATTCCACATTTCATAGAATAGAGGTTTTCAAGGAAACCCCTGTTGACCATGCCCTAATTTCCTATTGATTTCTGTTCTATAATTGAACAGATAATCCTATGGAAAATGTTTTGTTTCAAAATACAGGAAAAACATTCCTATTCCCTTTCTGAGGCTGGCTTTCCAGCAGTTGTTTCAAAGGAAAAATAGATCCCCTTAAAGAAAAAGTATAGGCTTTAGGGAACAAAGGGACAAGCAGAACAGATGTGGAAGAGAGATTTTCAGGAGAGAAAAAATTGATAGCTACAGAGATGGGTAGTTAGAAAAATCGTAACTTATATGTGAATAAAATACATATAAACAGCATTTACTGTAGTGGCGTTCTACTTATTAAGATGCAATGAAATGAAGAAAAGCTTCATGTCCAAGGACCTTTGCCACAGTTCAGCTAGTTGTAGTTTTATACAGAAATGATCCTGAACACTCTGAACTTGACATAGTCCTGCGGTGATATTCTATCTGCAGTATTTGTACCTCCAGAATGGCAGATCCCTCAGCAGGAACAAAGGCGTATTGACGGTTCTCTCAGCATGTGCAAAAAAAGGTACTTCCTGAAACTTTTGATTCAATAATGGCTAAACATACTATGTACACAATTATTGTAAGGCTAATTCACGTGCCATACTCCACCTGAAAGCCTGAGTTATCTTGCTATAAGCTTTTCATGGAGCACTTCCTTTCCAGAAACTGATTTGTAACTCTATTAGAGAATGTCCTGGTGTCAGTTTTTAGCATATGTAGTATTTAAACAGAGCTAGAATGTGATGTCTGAAGATAGTGCTGCATTTCTAAGTTTCTTGTGTGGATTTTAAAATAAATTGTGCCTACAAATATAAAC 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@rCer/1607/25_1656_CCS ATGGGGGCACTTTCGGCTCCTTCCCTTTCCCCGGCCTTCCAGCTTGGTCTTTCCGGGCCTCACTTCCCCCAGCCCCTGCGCCGGGCCCGAACAAGAGGTTCCGGAGCCCCGGTGCGGGCGGATTCTGGGGTGTAGACGCTGCTGACCAGCCCGCCCCAGCCGAGGTTCTCGGCACCGCCTTGAGAGCTTCAGCTGCCCAGGATTAGAATCCCAAGAAAATCAATGGCATCCGGGGATTTCTGCTCACCTGGAGAAGGGATGGAAATACTTCAACAAGTGTGCAGCAAACAACTCCTCCTTGTAACCTGAGTAAGAGAGACTTGTTACAGAACCCATACTTCAGCAAGCTTCTCCTGAATCTCTCACAGCATGTAGATGAGAGTGGCTTTAAGCCCAACCCTGGCAAAGGAGCAGGCTCAGGCATGGAAGGAGGTTCGACTGCATAAGACAACATGGCTGAGGTCTGAGATTTTACATAGAGTCATTCAGAGTTGCTTGTGGACTACTATGTGAAGATGCAAGACACAAATGTAACTTCTGAGGACAAAAAAGTTTCATGAGACCCTTGAACAGCGGCTACTTGTAACTGAACTGATGCGGCTCTTAGGTCCTAGCCAGGAGAGGGAGAATACCTCCACTGCTGGGGATGGAGAAAGCGGACCTTCTGGAACTCATGCCACTCTCAGAGGATTTTTGTGTGGATGAGGGCTCGGCTACAGCAAGAAGTAGAGGAGCAGCTCAAAAAGAAATGTTTCACTTCTGCTTCTGCTACTATGATCCCAATTCAGTCCTCTGCCCCCTTTGCCCAGATGCTGACAGTGAAACCGTGAAGGCAGCAAAGGTGTGGAAACTCGCAGAGGTCTGGTGGTGAGCAGCAGCAGTGCCAGGATGCCAAGAGCCAACAGAAGGAACAGATGTTGCTGCTGGAGAAGAAGAGTGCTACTTACTCCCAGGTGCTTCTCCGCTGCCTCACTTTGCTGCAGAGGCTTCTTCAGGAACACCGGCTGAAGACTCAATCCGAGCTAGACCGCATCAATGCCCAGTACTGGAAGTCAAATGCAGTGCTATGATCCTTAAGCTGAGGATGGAGGAGCTAAAGATTTTGTCCGACACTTACACTGTTGAGAAAGTGGAAGTTCATCGTCTGATTAGGGCCGTTTGGAGGGAGCCATTCACCTACAGGAGCAGGACATGGAGAAGTCAAGACAGGTCCTGAACTCCTATGAGGTCCTTGGGAAGAGTTTGACAGGCTGGTGAAAGAGTACACCGTACTCAAGCAGCAACGGAGAACAAGCGGTGGGCTCTCCTGGAGTTCAACAAGGCCTATCGTTGAGCTCTGGCAGGGCCAGGAAACATGGCTTCTGCACAGCTGCTGCCTCCTAATCTTCCTGCTAGTAGGCCACCTTCACCTGGGGCTGCCTTCACTACAAGGGAGTGTGGAAATGCTTACGCTTACTGAAACACTGCAGTCATTTAGGCACCCTCGTGGTTTCCCTTTATTTTTTATAATGACTGGGCCTCTTCTGGAAAATCTAGCAAAGCAGATTTATATAATTTTTATGCATAGCTGTGTGTCAGTGTCAGCCCTGTATTATATTTGATTATCTCCTGAATAAAGTATGATATTATAT 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@rCer/1608/25_2182_CCS ATGGACCGCGGCTCCCTTGTTCCGCTGGGGCCTCCGGACGCGCTCCCCGCGCAGGTCTCTGGAACACTCGGGCCGAACGTAAGCCCGCTTGCACTCACACTGCAGTTCACACCCGCAGGCGCGCTCGCACCCACATTGCCGCTCACGCGCGCTCACACTCCCCCACGCGCGCTCCACTCCCGCTCCAGCCCGAGCCCCGCGAAGGCGCAGGCACCGCCGCCGAGAGCGCCAAGGGGCCCCACGGCCTTCCCATGGCGGACCTAAGCTTCATCGAAGATACGGTCGCCTTCCCCGAGAAGGAAGAGGATGAGGAGGAAGAGGAGGAGGGTGTGGAGTGGGGCTACGAGGAAGGTGTTGAGTGGGGTCTGGTGTTTCCTGATGCTAATGGGGAATACCAGTCTCCTATTAACCTAAACTCAAGAGAGGCTAGGTATGACCCCTCACTGCTGGATGTCCGCCTCTCCCCAAATTATGTGGTCTGCCGAGACTGTGAAGTCACCAATGATGGACATACCATTCAGGTTATCCTGAAGTCAAAATCAGTTCTTTCGGGAGGATCATTGCTCAAGGGCATGAATTTGAACTGTATGAAGTGAGATTTCACTGGGGAAGAGAAAACCAGCGTGGTTCTGAGCACACGGTTAATTTCAAAGCTTTTCCCATGGAGCTCCATCTGATCCACTGGAACTCCACTCTGTTTGGCAGCATTGATGAGGCTGTGGGGAAGCCGCACGGGATCGCCATCATTGCTCTGTTTGTTCAGATAGGAAAGGAACATGTTGGCTTGAAGGCTGTGACTGAAATCCTCCAGGTATATTCAGTATAAGGGGAAAGTCCAAAACAATACCTTGCTTTAATCCTAACACTTTATTACCAGACCCTCTGCTGCGGGATTACTGGGTGTATGAAGGCTCTCTCACCATCCCACCTTGCAGTGAAGGTGTCACCTGGATATTATTCCGATACCCTTTAACTATATCCCAGCTACAGATAGAAGAATTTCGAAGGCTGAGGACGCATGTTAAGGGGGCAGAACTTGTGGAAGGCTGTGATGGGATTTTGGGAGACAACTTTCGGCCCACTCAGCCTCTTAGTGACAGAGTCATTAGAGCTGCATTTCAGTAGCCAAAGAGGACAGGAACCCTATCTTCATGAGGGAGGAAGACAATGGTCCTATAGAGCCCTTGGATGAGAAAGGAAACTTTTGAGCTGCACCTTCAGTTTATCCTCAAAGCCTGCGTTGTCTTCATCTAATCCAGCTTTGATGGATGTCTGTGATGGTTGCCTGTACACTTGCTGAATGAAATATTAGAAATGGCTGTATATTCCAAAGAAACCTATATTATATATCCACGTTACTGCTGCTAGGATTCATATTTGCACGTACTGTTTATTGCTTATGTGTAGAGGGAATGAAAACTAGTTTCCAGAGTTGTTATTAATCTGAATATATATCATGTGTTAATATTGAGAAAGGAAAAATACATTCCAGTGTTAGTAGTTCTTCATTTCCTGTCTCCAACAGAAAATTAACTCATTTTAAAACTAGTGTAATTCTTGATAATAAATTAAGAGTTTTGATTAAGAACAGCAAAGAGCTTCAAAATGTAAAGTGAATGATTAGTAAAATTATGTCTCATTTTATTTTTTCAGCACCCATACCACAATTAACATTAGGCTTGGATTGCCATGGGAAACATTTTTTTTTTGTGTTAATGCAGCAACATAATACTCACTTTATGTATTACTACATAGTTAAAGATTTAACTGAATGTATGAATCAAATATATTTATTTGACCTATTCAAGCTGTGGTTTATAGGAATTTTGAGAAGGTATAAGAAATTAGGATAAAAGAAGGTCACCACCATGTACCAGAATAGCTTTACTTTCCATAAATAGAAAATATAAATTTAATGGTATCCTATATTACTTAGTGTTGTATTACTTCGTAAGACTTAAAAATATTTTATTCTATGATTCCACTTCTTTAGTATGTTAAGACATTTCTTTTAAAGATGACCAACAATATCCTTTATTTTAGGTGCTACTAGCAAATGTAAGCATATATTTAGTTGCAGTTAGATGTGACAGAATGAGATAATTTATGTAAAGTAGTAGAGTGCCTGGCACAAAGCAAACAATAAATGTTATTGTT 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2634425115041/50*11,3423220344-52*216665/564-0200/43446.32434646414.4+65-.-05463.1226/61..3212644.6644513,042+.022)+/+-.15142/344)43/02&22*0/+34...31511/333554%1/.++,--+...00//350+32133535'5524),354/3445245.0/3615240555,..,,.5042655/545-46312-5/.,0-2345-5/36455,/1433324661.33./34,00262653$.,,00511//45*/35114126523/54534(.4103313..6330'431.,244**01656/.060/30/234/4121)+).44650+23.-,220522*1.0164-/12+45413-01631/11/2/646665302614+1..2,4640/+0.4/232./-0361)4413)14.*32),*1466525/3.01)-4412-6/3*2-416141&12*42,16404/.44312121-10)01,/,-+100*1.1121*,/0,2-+,100*(-.*%/0*1/221)++,1+0+++./00*,.11.0--1-0*/./,0.0122&-/00*.11001/00-12/.)*--,.11-110$0*+*/10*111102/./22*1/01)/010-1.),+-0211*+0///)+0010.11.0/,0.0100-//0100*0-/1+/002.0-1/011112,1011.00/++,.01/-1-#-(%(-/'*)01'.*01-0(..10100'//$//,2101)++0111/+/0(*0/',.&)#-/),1--0++*++*(-,#&$*-/,$,-/**+/+)-,2.11/2,.*00.12.,/'.-+-1).0+0.,21/,,0+-/.$**'$*+,+(**''*',.*21211,/.-0..011).10//+,..,011-/+0.1-010/102*/,+-,,0)21--0-20),*'/1-/),1-1211.*,--01.-0,.112/221.-2.2111010).1.11012-,$0//0/..121-0-.)+.2+1./*.11/',++,2/2&-//11'//-$/*/-1)111111/,021-021/1111-*,*00112+.-..10001-20.+010.2.2210-/1/001)/*-21,11*.,/*./,/2112121..$0*-0-/.+-0+(,+0201.,0,+0-0&10-,/2.-&-.,/+1011-*0012,.-.02)/12,*,+0'*.0111+1-/1-.,/.0/12-.2.0/*01.-0-20,,*01.01,()-'1/)1/1%/.*0,+/0-0$,).1/2.0.1+$$-0/-200.+*1101(,-21.(0,$/-*10(*011111/21,/,///,+011.-0-1.(0.,-/-221,+,)*//1112..,2/1)/+**(++*%+.22-00/).10000*.22-2/001,//-10,0,0110.,21,.101.10,+.1/0-211,211,/12//-/(/.,01-)+*/),,/*,11101-*,.//1+10.2*-.-)*1,00/1*/(.).020,+,&)*('/0,),/*%/0*-&.*./*,/(+,--0*002,'/)1-1+&.2,-*,100,+&+.1101)/-&..))+'('-(()'+%+,+-.1,+00-*--.-,,,--*/.,+&.-.--.+.-**21+($'&+--(+*-.*+-/*-.)%(&+&.00&,00++*.0-+)$++*'%%$&$$$')++-)**)*(,-025./.01-+0/'00)+21.-4/21,24(,/35-50$$&/4)2.42+40+()'/+650)/'$+-(%+-+(*---'(#('((#&)(,++$,#)*)*'*-((%,)&*%'$&###$"#%'())#''%*%(#+'&'(''''&&%*&%)#"'++),(%(-++)*$)+()+-()+,++*.-,,'(-('))+,-(+*+.-+.-+)(++,*,+.+*#+',%&)-)(&&),',.-('(++),(*#****(,%(,,,-,,''#)+'*(-,+(**-..,---,($-'),')-+..,),,*(-,*%(+)&(&*+%,$')+,#)**(-*--).,+(,+,)(,--..-,--,,-,,,+(#'**(,,)*),(++--,,,(+(,*+-(*,,*()(&,)--*--..-*--*,%'--+((,-.*#)+-.-,)-))(-,(+-(,)-+()($' @rCer/1611/1806_57_CCS ATGGGGAGTGCCTGCCTAGGTTGCGCCTCTGAAGCGGGCCTTTCTCTTTCTCAGGTGAGCCTCATGCTAAACGGGTGGCCGGTGATTTCAGCCTTCGCTGGTGACCAGGACGTGACCCGGGAGGCCGCCAGCAACGGAGTCCTAATCCAAATGGAGAAAGGCGACCGAGCATACCTCAAGCTGGAAGCGGGGAAACTTGATGGGGGGCTGGAAGTACTCGACCTTCTCCGGATTCCTCGTGTTTCCTCTCTGACTGGCTCATAGCCTGAAGGGAGGCGGGGAGAGGGCGAAGCAGAAAGGGGAGTGAAAAAGAGGCTGAAATTAAGAGGGAGAGAAAGCAGCACGACTTGAAACTTCCTACATGTTCTCTAACTGTATCTGGGTAAAAAGGTGCGCGCCAGCGGTGGGACAACTTTGTCCATTTCCTTATTAGGAGACATAAATTTCGCTTAGCTCTGCGCACTCCCGTTTTCCAAAAATAAACTCGCCTCCCCATTCCAGTTGCAGTAATCAAGAAAGAGACGGCCTTGTCGTTGTTTCTTATCCCCCAACTTCATGTTCCCTGCAATTTATTTAAAGAAACTTTGTATTTCACTACATAATCTCAAATATTTCTCCCTAGCCCCTCTGAATCCTTCTGCCTACTGAAATCTAATATATTCCCCGCCCCAAACCTTTTTTTTCAGTTTGGAGAGGGGTAAGTTTTGTTGTTGTTGTTGTTTTGTTTTGTTTTGTTTTGGAATGGGGAAGGTACTTTTAATTTGGCAAGTGTTGCTCTTCTTAAAACACTGCTCAAGTTAATTAGCTGAAGATACTTAGTGTCCTCGGCTGCTTGTTAGCAGAGAAAGGACTCACCTTAGTGGTGACTGGTTTAAAAAAAAATATAAATATATATCATTTGTACACGAAGAACTCTTGCCAGTGGAAACTGGCTGTGTTTCCGTATTTCTATGTCCTACTCGGAGTGATCGTGAAATCTAAGGCTGCTTGATGTTCTGATGCTTGTCAATGCCGTCGTGCTCTGCGGCTCAACGAAACGCCAAGGAGCTTCTTCGGGACGCTTTCCTCTTCCTCTGTAACATACGTGTGAATAGCCAAGATTTAATTTTGCTTTTAATCTAAATAAAGTCGAAGCGGGACTTTTATTTTTCTGAAACAGCTTTCTAAACTCCTCATCTTCCCCAGCTGGGAGGTTGGGGGTCGGGGGTGCCAAAGGGCGAGGTTCTGAAGGGCAGGAGACTTGGGGGAACGCAACCATAGAAAGGCCTGGCGCGAGGGCTTCCTGCAAAGCCAGCCTTGCGCTCCTTCCTGTGCCAGGCCAGGGGCCAGCACTGCATTCGCCTGTGTTTACAGCTTTGATGCAAACGTAAGAAACGTGGCCGAAATCTTCCTTGGCCAGGCGCGGCCGCCGACCCAGGAGCGAAGTTTGATTTTTTTTTCTTTGCGTTCCAAATGCATCAGGAATAGTTCCAGTTTGAGGACCCAAACCACTCTACCTGGGGCGGCAGACTCCTCACGCCTTCTGTCCCCGGATGTCTCCACCGCGTCCGCCCTGCAGTTCCCGAAGCAGCGTATGTTTTATAACACCGCCCTCTGAATCCGGAGTCCACCCGCCGCATACTCGGGCGCCCAGGACCTATGATTCCGCTCATTCACAGGACTTTATTCAAGAGGTTCGTCCAGGAGTTTTAATTTGTATCGGAACATAATGTGAAAGCAAAATTGAAATAAACGACTTCGTTTTAAGTC 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00,-.)010*/+111///+,-%-11-+1,)+--0-.1(1-*'$,)+11*0++.))-.,.210,0*.%,),',1/+-2,-//0/10//,/',1,0%0//'/.1.-+#).),./,/-0+(0*%.2/2++1-+--1),+(00..101-12/0/)/.+&00...,.,.0./,)*++0/-%$000.,2.-%111//,11+12//,1.*'-/%,120/0.--.*.,1./1+./-'1.,/(0,,1010-1).0.+1-&/111.--..-//.00,..*/1*-1),120+01.,.*,-0(&-/-22,,,1(111,2020).,2.1110,*0011/-+-$/////+,..,-001-0/,(+.1,0/*0)-'/-+01)*-/(/&-0-/)1010./(0..1',*0101/*/,00*1,/2.*00**0./,-(.,//0(.)+&,..02.,-*//./+('()*0,0-0,/-+,-/,(-+*(((+*))$,)0-+/$*.0,.1.1,,+//,$-.-2.*.0,-//0121...%(1/(/1.&0000*2,00012*0-.%'&*0/-/,,(.'+'+($(%'%'(''.-*,20-0/1&,-',**()..(10102-/.10.1000//*-+-/$--,+-1.221/-.111$.1100'-1-1./--2,).-0.-%%*+%*,'+.-.'*0-)-101%#.#,/1..0101%.0///&101-(00.(,00-.-.$+1*0--0,,,)'-,.,),/1/*+-+.&.*+,(.))%11.-/2./*.10.0/,-/*0,20(10,-1(-./*-/-12.--($'',,//.,0./,,2,21010--0*-/*-100111110.-0--+)+02-1.,11*0*0,,+$*)-111-/.0'*++0).-,/+1/+1'(,./,*,-%1./2-+*$./-0101,.)+',**.+&'+.-10/0,12.0.-0(01(/+0(+0**0/2,210110/,10,,+-.&**..020..-1.&/))*00-/./-1+*010.0//00.0(0-000,,0-./.010/2)111.+11-0-/./'(*+.-/-2+,-,1*1,-+-*%0)1'//-(%(0,***$/*-+,)/+'+0112/-,&011-*.00),0*/&)(,,*+#///+,%010/'$-(&&*+-$-01-**/0/(010-*-),1,&-/-,-$01010-0/*+11*,0-%'))('(*,0+,%))*&+0-*(,#-./0)*'.,*.-1/++*.,-'-1),/*-0,2-/&-(&*#(/%)+.*.+&/0,-/-+&-*)/10*-&//,/20-.&,'-.')0.'&00.,/+-&%'-,,)-0.01210**1.*',(*%//)(11,-1200/,200-2+0/'+,10/&+).+)'-0110)(*)*)+.0$.1-,/2,(/,10/.+)(-100(1,02+0*02*/,1./.0)/1,0*-.(*)/1-10//)/2..-0/.*//1)01.+-,/./0&1/.&1101+20-/*110010),'2/-//0)./1-000,,0,+0)+/0$&%+--0+&-*-101,.-+*0/)*-2//.(''0%10-../220,0.1.1110.)++*1,))0-112,),'/./%(,'01-/$'),*+.-.01/&*+'#0.211/+%&/001-)-+2/10-/&*-'*'*)*$&$,-.+*+%-,.2..-.,./11./12-201+,100.0/.02.1/--'.2++,&0/000,11-)+/211-00.$0*(($-+*110,2,,11/-,-()0-*&.12--++0-2/)0/+,0(/-.-0+.-,0+,)+ @rCer/1612/25_2073_CCS ATGGGGGCCACACTGCTTTGCTGCTCTTCTGCTCATGGAGCCTGAGGACAGCCCCAGCAATGTGGAGAAGTCTGGGGCTTGCCCTGGCTCTCTGTCTCCTTCCATCGGGAGGAACAGAGAGCCAGGACCAAAGCTCCTTCTGTAAGCAACCCCAGCCTGGAGCATAAGAGATCAAGATCCAATGCTAGACTCCAATGGTTCAGTGACTGTGGTCGCTCTTCTTCAAGCCAGCTGATACCTGTGCATACTGTAGGCATCTAAATTGGAAGAACTGCGAGTAAAACTGGAGAAAGAAGGATATTCTAATATTTCTTATATTGTTGTTAATCATCAAGGAATCTCTTCTCGATTAAAATACACACATCTTAAGAATAAGGTTTCAGAGCATATTCCTGTATATCAACAAGAAGAAAACCAAACAGATGTCTGGACTCTTTTAAATGGAAGCAAAGATGACTTCCTCATATATGACAGATGTGGCCTTCTTGTATATCATCTTGGTTTGCCTTTTTCCTTCCTAACTTTGCCGTATGTAGAAGAAGCCATTAAGATTGTTTACTGTGAAAAGAAATGTGGAAAACTGCTCTCTCACGACTCTCAAAGATGAAGACTTTTGTAAAAGTGTATCTTTGGCTACTGTGGATGAAACAGTTGAAGCTCCACAGCCCCATTACCATCATGAGCATCATCACAATCAGGGACATCAGCACCTTGGCAGCAGTGAGCTTTCAGAGAATCAGCAACCAGGAGCACCAGATGCTCCTACTCATCCTGCTCCTCCAGGCCTTCATCACCACCATAAGCACAAGGGTCAACATAGGCAGGGTCACCCAGAGAGCTGAGATATGCCAGGAAGTGAAGGTTTACAACATCTACAAAAGAAGCTCTGACGAAAGAGATGTATAAATCAATTACTCTGTAAATTGCCCAAAGATTCAGAGCTGGCTCCTAGGAGCTGATGCCTGCCATTGTCGACATCTGATATTTGAAAAAACAGGGTCTGCAATCACCTGACAGGTTGTAAAGAAAACCTCCCATCTTTATGTAGCTGACAGGGACTTTTGGCAGAGGAGAACATAACTGAATCTTGTCAGTGACGTTTGCCTCCAGCTGCCTGACAAATAAGTCAGCAGCTTGTACCCACAGAAGTCAGTACCAATTGACGCTGAAAGAGTAAGGCAAAAAAGTGAGAATGATCTTCAAACTAAATATTTGAAATAGGACATACTCCCCAAATCAGTCTAGACACAATTTCATTTCCAGCACTTTTAGAAACTACCAAATTAGTAAACCAGAAATCGAAATTAGATTTGTGCAAACATGAAGAAATCTACTGGATTGGCTTCCAGATTTTAAATTTTATGTCATAGAAATATTGACTCAAACCATATTTTTTTATGATGGGGCAACTGAAAGGTGATTGCAGCTTTTGGTTAATATGTCTTTTTTTTTTCTTTTCCAGTGTTCTATTTGCTTTAATGAGAATAGAAACGTAAACTATGACCTAGGGGTTTCTGTTGGATAGTTAGCAATTTAGAAATGGAGGAAGAACAACAAAGACATGCTTTCCATTTTTTTCTTTACTTATCTCTCAAAACAATATTATCCTTGTCTTTTCAATCTTACACTTTTAACTAATAAGTGGATTTTGTATTTTAAGATCCAGAAATACTTAGCACATGAATATTTTGCTATAAAAGCATATATAACTATGTTTTAAATATCCATTTATCTTCTGTATATCTAAGACTTATATCCTTATTTTTACTATCACACATGAATAAAAGCCTTTGTCTCTTTCTTTCTCTAATGTTGTATCACACTCATCTAAAACTTGAGTGGCTGTCTTAAAAGAATATAAGGGGAAAGATAAAGAATATTGTCTGTCTCTATATTGCTTAGTAAGTATTTCCATAGTCAATGATGGTTTAATAGGTAAACCAAACCCTATAAACCTGACCTCCTTTACGGTTAATACTATTAAGCAAGAATGCAGTACACAATTGGATACAGTATGGATTTGTCCAAATAAATTCAATAAAAACCTT 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4126524/554(2545105,&/2).-()+./24135-421%0434/44610'03105.1.110.423666421)-543153366415,'/.21.51546.5.6234164026655.,/55.26505226/45561366543614264-2$/.10644*.565/,3354212*4565242606525/1210524-223233665+&25151244,45,/,32)13/32'/.53$)/313626641-02154**-25465*/3624'2335465266665*(454234624/4353634,02$2+,,0*/)144/2/44/65164/3&21,022'0/6)10./1/335244-/)3453/-010,*+1,3(+/-+44246.454/135*422)3165.,00001263465.1,%/.026126642435155*505.0,15102531536-415043422611466542/.51/,01//66303*5234.31(13-+3/201644)5443625533+116*41360$0/023/4124632*/0,/,-3.14251135/*11/534141663106650315&04321032521.454304655.,5423/,#0('-*00,--,02.3.303.1-03,2)0//))-'1,*./.1103*22/65.235-322*51/*064322./31.*2/2-,(30,2231322/40.**221/1.,22-353341625.34)430,532-542420+-).+110150044..3630110043/.$.34.1/.64/442604+4211000.&,2*.+,.1+0,2*2302-141,0*//)+/.*,,)0/030/64004',515*316036,54,2.454.245)$/,/045*2..255032612661032541*04244(,&.046-3(1-()$&))$&+.//.4.,2+/+.4..1/--0060123&0052302/+,1&),..520211352-4-012/*4.444'/23441,)443154/-21+012/2414%/&010+03,,202-6/026551'4456550.365.4105251&140262625+4/304134%40/4.343+1.1/.1(1304026520/1211.1-*02.15.34004620456411(2535061516501334111525/41015-30+/.34242152,60*43453316245566644665-410104613)45-,5314.51/425505653466643/5414/434143-5514165-2561-0146655/5206403(1,20004)434434-43245-54.4144-51.11.23504+1*620354553646522635252*42655655033*22211264631.*00402433.1.-65.42/2#.0-/1,-35.504/44,4/44060(5.,3166353405341/-1/444,10*$--/12110..%543.44234/5651*5541)20/040.124566466-/+(450/-/53)/.0(431-230003615152215324/4,4003%143.43/5061/2514326241-01.('4-)0-+3236643&101)03/210/22.655105)*(),24623365-5-4-3660-/*1.1'423.123-03)204353.3253//-562-54114643.0/.05/1%*)2./.3032624311..0320621-++/,1115*/002*43--5121..51'+411436013513/*2633513.1-05035.20-54444/5314.33*//0/40'1144.536563502-654165-04.0-550120.30+003346245,5144.1404400-.).3*1.355-&-.)0/4.435366/44)/40*+,5-655*2+0124340.-354-6520/24-3*212660.543135505/3-04-2.2463/4603/5.')/.3134236530)/204.465/*/24.4(.0004605,4/631342/4503463560221-1530/45206/-6302(3,440&0**4.*0+*136656,3 @rCer/1614/0_710_CCS GCAGCGTGAGGACGGGACTGGTCTTCCGCCACGCCCAGGACTCATCCTGAGACCATCTACACCGAGCTGTCGACCTGTCCCTGGGCACCTGGGGAGATCAGCGGTCACCAGCTCATGAGCCTGTCTACTGCCGATGCCAAGAAGGACCCCAGCTGCAAGACCTGTAACATCAGCGTGGGCGCTAGGACTCCTGGGAGCTGGGGGGCGAGGGAGAGAGAGCAAAAGGTGAGGTCACCAGGTGGACTCCCTACAATCAGCAAAGCAAACAGAGAGCCTGTGGAGGGGCTGACAGCAGCCGCCGGCTGTTTAGGGATGACGGAGGTGACATCAGGCGGAGAAGAGTGCAGCCTCACAGTGACTTTCTCAGAGGTGACGGAGATGATGGATGAGCAGCTGGATTTCCATGACGAAGGACAGAAGCGGCGGCAGGCCGGCAAGACATACCTCGGTGAGGGCAGGTGACAACCGTCGCCTCTCTGTAGCCAGGGGAATTGTGTGGCCAGCTGTCTCTCTGGATGGTCAGGAGGCCTGGAGGCTTCCCGGGAAAGAGGTGTGGAGAAGGAGAGAACATGCCCAGGCCCTTTCCTTCCCTGTCTGACAGCATTGCTGTAGGGGTGGCTGCTGCCTCCCCTGGCCCTCATGTTCCCCGGGGCTGGGGTCCGCCTGCCTGTGCTGTGCTTGCGACGTGCATCAATAAACCACCATGGCCT + S3678(3744824$63,#-17,5.95:42:7/70611434%/366593+-)1(-163566157,0*&66:67705:65(356*7/-.'.0%4868/7-2(*,*,20.+(.,1/327::7*88;;<:403:/:1474,2)826?,76%23683326<3956.47<83216639-388041&4.47&636=692$5-)36=,@;=>>A4:&035%-.$%267%#*9'3&%489>;443*&,0+468>2=67:=4B:?:6-2=1:7;===67<>'<0'3;;7:;,0::?28/1>&5.<69=.886,:84=B>?9=9(0046<;9588;84?7.4928<9@0>23>?@67;;?75=5==62496925723*05/,075335;/.03(:;85<5==3>A*75;@?=;=A6?A?9??C;@4@4*>A@9C,@,@AA>39&:<4.=;A9C:78&;<:507.0:9@AA=;?=>:?:718>@>>'*52$4136<12??8=2:.8898;6>?>;><2%;4/%3=8A:<:%8,;<6:?.:-%8%9.%42/7<:97;94;3@=;992=13:37<;5<$$26.9;&07)96,:(/):7).*%;:795:51:7>10/79%;545(%$*667;&86'1<=@/;)<9>96;:68&5)(&/8758.=?====9/=6=1><<;;A464>=+;>B<,9>3:<9>5.;73=:/5.;@>95?*9/ @rCer/1615/25_2125_CCS ATGGGAGGCGGGCCGGAGGCGGTGGCTGCGGCTGCGGGACCGGTGGCCGTCTGCCCGGCCCAGCGCCATGCACACGCTTGTGTTCTTGAGCACGCGGCAGGTGCTGCAGTGCCAGCCAGCTGCCTGCCAGGCCCTGCCCCTGCTGCCACGCGAACTCTTCCCCCTGCTGTTCAAGGTGGCCTTCATGGACAAGAAGACAGTGGTACTGCGCGAGTTGGTACACACATGGCCCTTCCCGCTGCTCAGTTTCCAGCAGCTGCTACAGGAGTGTGCCCACTGCAGCCGTGCCCTCCTGCAGGAGCGGCCTAGCACTGAGAGCATGCAGGCCGTTATCCTGGGGCTGACTGCCCGGCTCCACACCCCAGAGTCTGGGGCCAGCACACAGCCCCTCTGCAGGAAGCATGCGCTGCGGGTGCTGGACATGACAGGCCTCTTGGATGATGGTGTGGAACAGGATCCTGGCACCATGAGCATGTGGGACTGTACTGCTGCCGTGCTCGCACATGCATCGCCCAGCAGCAGGGGGCGCCACAGAGCCTGGGCAGCCCCCATCCCGTGAGGTGCGTGTGGACCTGCGGTGAACCGGGCCTCCTATGCCTTCCTGCGGAGGCACTCCGAAGCAGCGTGGGCAGCCACTGCGGCTCTGCTGCCGGGACCTGCGAGCTGAGGACCTGCCCATGCGCAACACTGTGGCCCTGCTGCAGCTTCTGGATGCAGGCTGCCTGCGCCGCGTGGACCTGCGCTTCAACAACCTGGGCCTGCGTGGCCTGTCTGTAATCATCCCACACGTGGCTCGCTTCCAGCACCTGGCCAGCCTGCGGCTCCACTATGTGCATGGGGATTCAAGGCAGCCCTCCGTGGATGGCGAGGACAACTTCCGCTACTTCCTTGCCCAGATGGCCGCTTCACCTGTCTGCGCGAGCTCAGCATGGGCTCCTCTCTCCTTTCAGGGAGGCTGGACCAGCTGCTCAGCACCCTGCAGAGCCCCCTGGAGAGCCTGGAGTTGGCCTTCTGTGCTCTGTTGCCTGAGGACCTGCGCTTCCTGCACAGAGCCCCCATGCTGCCCACCTCAAGAAGTTGGACCTGAGTGGTAACGACCTGTCTGGCAGCAGCTGGCACCATTCCAGGGTCTGCTGCAGGCATCAGCAGCCACACTGCTGCATCTGGAGCTGACTGAGTGCCAGCTTGCAGACACCCAGCTGTTGGCCACACTACCCATCCTGACTCGGTGCACCAGTCTCCGGTACCTTGGCTCTATGGCAACCCACTGTCCATGGCGGGCCTCAAGGAGCTGTTGCGGACTCAGTGGCGCAGGCTGAGCTGCGTACTGTGGTGCACCCCTTCCCTGTGGACTGCTATGAGGGCTTGCCCTGGCCGCCGCCTGCCTCTGTCCTGCTGGAGGCCTCCATCAATGAGGAGAAGTTTGCCCGCGTAGAAGCAGAGTTGCATCAGCTGCTTTTAGCCTCAGGCCGTGCCCATGTGCTCTGGACCACGGACATCTATGGGCGACTGGCTGCAGACTACTTCAGCCTATGATGAAGTAGCTCTGGGTGAGACACAGGGCTGTCCTGCAGTCTCTTTAGGTAGGCAGGGCCTTTGCTGGGACCCTGGTGGAGGCCTGTCACAAAAGCACTGGTTTCTGGTTTCCTGCTGGGTCCGCCTTGCTTCTGGGCACACCTCGAGCCTCCCCTGCTTCTGCAGTGCCCCACGCGGTTTTCCCTGCACTTGCTCCATGATTGGTGACCATTCTGTGGCCCCCAGGGCTGGATGTCAGGCTTCCATTGCCCTGCTCAGTTTGGCTGCATTTGGCTGCCCTCTGGGGTCCTGGTCCTTTGTGCAAATGCTTTGGGATCCCACTTGTGAGTTGAGAGAGATGATGGCCTCTCTGAGCCTTTCCCATCCCTTTACTGAGAGCTCAGTGCTCTGGGGTTGAAGTTGGACAGAGGCTGCTTCAGGAGGCTGGGGTCCCCAGGCACTCGTGCCTCTTAAACGTGTTCCCTGCCCTGCCACCCAGCCACCCCACTGGGCTGGGCTCGGGCTGGAGGGGGTCATCAAGGTACAAATGTGCCTGGAAATTGAATTTATGGCTCTCTTTTTTCT + 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@rCer/1618/2189_58_CCS ATGGGGTGCTCCCGGCGAGCGGGCGGAGAGCGGGGGCCACACTGGGGAGTGTGGGCTGGGCCGCAAGATGTCATGTGGCCTGTGTTTTGGACCGTGGTTCGTACCTATGCTCCTTATGTCACATTCCCTGTTGCCTTCGTGGTCGGGGCTGTGGGCTACCACCTGGAATGGTTCATCAGGGGAAAGGACCCCCAGCCCGTGGAGGAGGAAAAGAGCATCTCAGAGCGCCGAGAGGATCGCAAGCTGGATGAGCTTCTAGGCAAGGACCACACGCAGGTGGTGAGCCTTAAGGACAAGCTAGAATTTGCCCCGAAAGCTGTGCTGAACAGAAACCGCCCAGAGAAGAATTGATGGAGGACACAGGGCCTACGGTCCTACTGTGGGCGGTGACTTGTCCTGCTACCATGTTGACAGAGCCCCAGAACCCACATCTAATTGGCTTTGTTGCTTATTCTGGCCCCTCCCACACCACACAGCCACACAAATACTGGCTGCTCCTTCATGTCCAGGCAGACCCAGCGGCAGCCAAAGGGCCAGTGAAGAGGAAGGCCGCATCTGTTGTGTGGTGGCCACAAGCACTCAGGCATCTGAGTTTACTGGTGCACTGCTGGGAGGAGTGTTATGAGATGAACGTTGGCTGTCAATCTCTGTGGGCAGGCGGTTTGGCCTCGAGTGGGAATGGCTGGGATTTGGGTGTTGCCTTTAGGAGGGATACCTGCATGTCTAGTTCCAGTCTGCACTGGGAAGAATTCAAATATGCACCTGGCTCCCTTCACTGTTTTGCCCTATCCTTTGTGCTCATTCTTACTGAAATCTGTCTTGTCAGCTCAGGAATGGGATTCCCCCGGGAAGGAAAGCATTTTTCTGTTCTGGGAAGCCCAGACTGTTCACTTTGGGGCAGGACGAACATGTGCCTCGTGAATTTGCTTTGAAAACAGTCCCATCATCTACCCCCATCACTGTAGAGTACAAAACTTGATTAAAGTGGTATCTGAGAACCATAATGATCGAATCTTATCATCTAGATGGTATTTGGAGTCTTCTTAGGAGTTAGGCAAGTACAGGTGTTTTAGAGCAGGATAACATTGGTATTAAAGGGTGCCAAGGAGCCCTGGAAACTGCTTTACTAGTGCGGTTGCATTGAACCCTGGAGGCACAGATTCCTAGGAACCTTTTTTACCATCATTACAATTGGCCTTAGCAGCTTCAAGTCTAAATGGAAGTAGACCACACACACACACACACGCACACGCCTTTCCCTATAAAAGTATATACGGCACATTCAAGAAGATTTGGTAGGGATTTTAAAAAGGGCACCCATGTTCCCAGCTCGTTAATAACAACCATTAACATTTTGTTGTCTTTTTACTAATTGTCTGCATAGGTTTTAAAGATAGTTATTACTGTACATTTAATTTTATATACTTTTCTTACATTATCATTTTTCCATTTTGTGTGGTCATCATTCACGGCTCAGTGCAACCTTGACCTCCTGGGCTCAAGTGATCCTCCCACTTCAGCCCCCCAAATAGCTGGGACTACAGGAGTATGCCACCACGCCCAACTAATTTTTTTATTTTTTGTAGAACCAGGTCTCACTATGTTTCCCAGGCTGGTCTCAAACGATCCTCCGGCCTTGGCCTGTAGTTTTTTTTTTTTTTTTTTTTTAATATGGAGTCTCGCTGTATTGCCCAGTCTGGAGTGCAGTGACGTGATCTCGGCTCACTGCAAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGTGCGCGCCACCACGCCTGGCTGATCTTTGTATTTTCAGTAGAGACAGGGTTTCACCATGTTGGTCGGGCTGGTCTCGAACTTCTGACGTTGTGATCCGCCTGTCTTGGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCGGCTGTAGTTGTTTTTTAATAGCAACATAATTGTCTATCAAGTGGGAGTATGGCATAAGTTTATTCTGGACAGTTTCCATACTGCCGGACATTTCAATTGTTTCTGGTGGTTCACTTGTTTAGATACTGCAATGAATATCTTATATGAAGCTTTTCCTGCATTTTTGGAATAAACAGTAAAAATAG 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@rCer/1619/25_1682_CCS ATGGACCCTGAACTTCTGACTAGCACTCGAGTGTTGCAGATGCCAAGCTGACCTCGGCCGCTCTGCGTTGGGCCAGCCCTCCCGGTGGTTTCTCACCACGCATCGCGCAAGCGGAATTTATGCTATTACCGACACTCCTGCGCCCCCGCACCCGCTCCTGTGCGCAAGTCGGAATCAAACCTCAGAGAGTGAGCGTTCCGGGCGTCCAGTTGGTTGTCGCGGCAGTCTCTGCGAGCAGCGCATTTGTCTTCTAGGCTGCGTGGTTCGTACCTCGAGAAAGGAGTCAGTCTCCTGCTGCCAGCTAAGTGTGGGAGAATTGTGCACGTATCTCCCTCCGAATCCAACGATGGGTAACGTCAGTTTCGCCCAAGGAACAGCAGCTGCTGCAGCGGTTGCGGCTTCTGCCTGCCCTGCTTGTCCTCCGCGCTTCAAGTCCCACAGGAGGATCAGAGATTACCGCGTCGTGTAGTCGCACCGCTGTGTGGGGAAAAGCACGCTGCTGCACAAGTGGGCGAGCGGCAACTTCCGTCATGAGTACTGCCGACCATTGAAAATACTACTGCAGTTGCTGGCTGCAGCCACGGTGTGCTTTCCCTGCACATCACCGACAGCAAGAGTGGCGACAGCAACCGCGCTCTGCAGCGCCACGTTATAGCCGGGCCACGCCTTCGTCCTGGTCTACTCAGTCACCAAGAAGGAAACCCTGGAAGAGCTGAAGGCTTCTATGAGCTGATCCGCAAGATCAAAGGTAACACCTGCATAAGTTCCCCATCGTGCTGGTAGGCAATAAAAGTGATGACATCCACCGGGAGGTGACCTGCATGATGGTGCCACCTGTGCGATGGAGTGGAATTGCGCCTTCATGGAGATCTCGGCCAAGACAGATATGAATGTGCATGAGCTGTTCCACATGCTGCTGAATTACAAGCAGCAGCCACCGACCTCCAGGAGCCGAGAAGGAATCCAGATGCCAACACCACTGAGAAGCTGCTTGACAAGTGCATAATCATGTGAGCCCTGGCCTTAAGAGCCAGCTCTTCCTATCCTGTAGTGTGTAGAAAACGTGGACTCATTTCACCGTGTTACATGTACATGGTTGATTTTGTGCTGTTTGGACTGTAACATCCATATTGTCAATAAATATACCTTGTAGGTGATAACTTCTTTTTCCCAGGCCAGAGAATTCAAATTGTTAAAAGATCGGCATTTGAAGAGGAGAACAAAAGTAGCATGATGTATTTAAAGTAAGCCTTTAGTAATAAATGTAATAAGAGAAAATGTTTTGAAAAGAACAAAACATCAAAATGAATAGAAAGAAAAATTGGAAGGTGTCTTTGGTAACCCTATTATTGTGTATTACCTTTAAACATTTCACATCGTGTAAGTGTTTAATCATATCTTTTAATTGTGTATTTAATTAAGAAAAGTGTTTTCACAACAAAAGCTTTTGACAAATTGCTGCGTGACATATACTATATTAAAAAATGAATATGCTATAGCTGATCATTAGGGTTTGGGAGCAGAGAAAATTGTGAAAGTGGAACTCTCTCACTAAAGATGTTAGTAGTTTCCTATGTCCTTTAAAAATGTTTGAGTATTCTGCATAGCAGTTTAAAAAGTGTAACCGCTTCTTGACTTAATAAAGCTTTTCCTGCAT 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@rCer/1620/1872_50_CCS ATGGGACACGGTTCTCCAACAGGCGGCGGCGGCGCTGCGGAGTGGCTGGTGCCGCTGTCCACGGAGATGCCTCGGCAGTGGAATCCAATTCCTTTCCAGCCACACCTACTCCACGGGTCGACCTATCAGATGCGCCGGCCGGGGCGGAGAGCTGCCACTGTCCAAATCATATTCTTCTGGAAACAGAAAGGCTTCTGTCGGCTTGCTAGATATGTCAAACAAGAATTAGCCAAAAACAAAGAAATGAAAGAAAGTATTAAAAAATTCCGTGACGAGGCCAGAAGGCTAGAAGAATCAGACGTGCTCCAGGAGGCCAGAAGGAAATACAAACCATCGAGTCAGAAACCATGCGGACGAGCGAGGTGCTGCGGAAGAAGCTTGGGGAGCTGACGGGCACCGTGAAGGAGAGCCTTCATGAAGTCAGTAAAAGTGATCTGGGCCGGAAAATCAAGGAGGGTGTGGAAGAAGCAGCCAAGACAGCCAAGCAGTCAGCCGAGTCGGTATCCAAAGGTGGGGAGAAGCTGGGCAGGACGGCGGCCTTCAGAGCCCTCTCCCAGGGGGTGGAGTCGGTGAAGAAGGAAATGACGACGCGTCCTGGGGCAGACCGGGCCCTACCGGAGGCCGCAGCGACTCCGGAAGAGGACGGAGTTTTCGGGAGAGAAGTTCAGGAGGAGAAAGTGTTTGAGCCAAATGAGGAGGCCCGGGGGTCGTGCTGCACAAGGACTCCAAGTGGTACCAGCATGGAAGGACTTCAAGGAGAACAACGTGGTGTTTAACCGGTTCTTCGAGATGAAGATGAAGTATGATGAAAGCGACAACGCGTTCATCCGGGCATCCCGGGCCCTTACGGACAAGGTCACCGACTTGCTGGGGGCCTGTTCTCCAAGACAGAGAGTCGGAGGTGCTCACAGAGATCCTCCGGGTGGACCCAGCCTTTGACAAGGACCGGTTTCTGAAGCAGTGCGAGAACGACATCATCCCCAATGTCCTGGAGGCCATGATTTCTGGAGAGCTTGACATTCTCAAAAGACTGGTGCTATGAAGCTACTTACAGCCAGCTGGCCTACCCCATCCAGCAGGCCAAGGCGCTGGGTCTCCAGTTCCATTCTCGCATCCTAGACATTGACAACATTGACCTGGCCATGGGCAAGATGATGGAGCCGGGGCCGGTGCTCATCATCACTTTCCAGGCACAGCTGGTGGTGGTGGTCCGGAACCCTAAAGGCGAGGTGGTGGAGGGCGACCCGGACAAGGTGCTGCGGATGCTGTACGTGTGGGCGCTCTGCCGAGACCAGGACGAGCTCAACCCCTACGCCGCCTGGCGGCTCCTGGACATCTCAGCCTCCAGCACCGAGCAGATCCTCTGAGTGCGGTGCCACAGCCAGGGAGCCCCGGGCTGGGTCATCAGGCACAGAGGCACCACGACACCCCCTGCAGCAACTCCAGACCTCTGGGAACAAGACTGCGGGCTCTGCCCCCAGCTCTGCCAGAAGAGCTGCAAGACCAGCTGGCCGGGGATGGGACAACGGGCTGCTGCAGGTGCCTGGCAGCTGGAGACACTCCCCCCAGGGCCGGCCCCTGCCCTGTTGCCTGCCCTGCAGGGGTCCCGGTGCCTGGTCACCTGGGGTGCACACAGGCCACCCAGTGCCAAGAGCCCCAGGGCCCAGGGACTCCTCCACAGCAGGGTGGGACCCGGGACCTACTGCTCAGTGGCCCGCTGGCCACGTCAGCTAAGCCACTTTAGGTCCATTTTATTTTAACAGTGCTCTTCCATTCTGTGCGTAAGCCCGAGATTTGGAAAGAATAAACCGAATTGCAGAAG 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@rCer/1623/1925_57_CCS ATGGGGGCTCCCCGGAGCTGGCGGCGGAAGAGATGGAGCCGCGTCACGGGCGCCCAGCCCCTTAAAACGCTGCTGGCTGGAGCCACCTCCCTCCCTGCAGCCCGCAGCGGGGATGGAGTAAAGGGAGACCCGTCGACCTGGCCTCGGGGATCAGCGATGGAGTTAAAGCAATCTTTGTCCACCCATCTGGAAGCCGAGAAGCCTCTGAGGCGCTATGGGGCGGTGGAGGAGACGGCATGGAAAACGGAAGGACTAGGGAGAAATCAGCTGGACATCATCTCCATGGCGGAGACAACCATGATGCCGGAGGAGATTGAGCTGGAGATGGCAAAAATTCAGCGTCTCCGGGAAGTCTTGGTCCGCCGGGAGTCTGAGCTCAGGTTCATGATGGATGACATCCAGCTCTGCAAGGACATCATGGACTTGAAGCAGGAGCTGCAGAACTTGGTCGCCATCCCAGAAAAAGAAAAAACCAAACTGCAGAAGCAGAGAGAGGATGAGCTAATCCAGAAGATTCACAAACTGGTGCAGAAGAGAGACTTCCTGGTGGATGATGCGGAGGTCGAGCGGTTAAGGGAGCAAGAAGAAGACAAGGAAATGGCTGATTTCCTGAGAATCAAGTTAAAACCTCTAGACAAAGTAACCAAATCTCCAGCCAGCTCCCGGGCAGAGAAGAAAGCAGAGCCCCCACCTAGCAAGCCCACGGTGGCCAAGACGGGGCTGGCACTCATCAAGGATTGTTGCGGGGCCACCCAGTGCAACATAATGTAGCCCCCATGTGGGGTGCCCTGGGGCCATGGGCCCCCCCCCACCCTCTTGTCTTTATAGCCCCCATTTCACCGGGGCCCAAGAGCTCTCCAAGGCAGAAGGGGTTGAAGGCAAGCCCGTGACTGTCGCCAGAGGCCATGGGCGCGGCAGGCGGGCCCGGCCACCCTGTACAGAGTGTAGCAGTAGGGAGTCCCTCACCGTCGCATGGCCCTCCCCAGAGCATGCCGAACCCAGGAGTCTGTCTCACTGTTTATCCAACCACCAGGAAAGGTCCTCCCTCAAAAAAGCGTATCTCCACTTTAGCTGTATCTAACCCACCGTGTGAATGAACTGGGAGAGGGGCATGCTCCCCAGCTGTGTGTAGTTGTGACTTCTCAACAATCTAGCACCATGTCGGACACATCCCCCATCCACCCTCCTAGCTCTGCTCTCAGGCCTGCCCCACATGGGCACAGGTCCCTCCCCTGTCTGTCCTCTCCCAACAACTGCGCCCTAGAGGGCTCCGCACGGCCCCTGTGTCTGGGCACGGTTCACAGCAGGACAGTGTCCACTGTGCTCTCAGTCTGCCCCAGGTGTGTGACTGAAGGGGGCCTGGACTGGCACGGATCCAGCTTGCAGAAGAGCCAGCAGGGAACTGGAAGCTCTGAGGTCAAGGCCAGGGCAGTTGAGAATGGGACCCAGAGTAGATGCTGACCTGGGCACCCCACCACTCCGGGGCCATCACAGAGATGCCAGCAGGACACCACTTCACCAGCCCGACACACAGACCTCTGTAAAGAACGGCGACGGGCGGGAGAGGCAGCGTGTGACCAGATTGTGTCCCGTCTTTGGGTGGCGTATATTAACTAGCTGCCAAACACTTCGACCTGTGTAACTCCATGTACATTTGCGACAGCCAGCCCGGTACAGCCTGTGTGACTTCTCTGTGTGTGTGTGTGTCGTGACCGGCCTAAGTAGTTAGCATAACTCAAGATTCGCTGATGTGCAGTCACCCATCAGAGAAAATAAAAATGGAAACCACGTTCACGGCATTTTAAAAGTTTTTACTTTTTTTCTTGATTATGGAAGTAATCCATGTACATAGTAAATCATTTTAAAAG + DEAKKK(JIKKKKK?KKKEKKKK/KKKJFIK.KKHJKJKIKKIJKIKIKKIIJIJKKIJKJIKGKKKBJKJJKKKKHJKJJKAICKKFKKKCKDHJ:GIJKBJKKJKJIHKIIJHJKKKK+KCJJIJGKKHJ8KK2I>CIKK?F?AKDIJHKK>@JIIIFIJKGKHK?K?JEIJGK=BHKEJHKKCIIBKKK@JIGGKKKGKJKJKKJKKCKK@KIJKKKJIKIJBD@KKKJ/FKKKKK'JJII6KDKKHJH=JKDJIGHG;F@BIEKJEIKIJKFJJK@@FGCJIJKK?HGKIHFIFI>2.-IJJJJD1KKKIIKKJHIGGJJIKGCJFFGKBEIJJKAKDKJEH8IKGIKEJBGKKCKJAJKK3H@JKFJIJKKK7JGKAKIKE:JKHB@;JJJEKCEKKCJJ*HJKJKKKEDIKKHEEFBHFJKIKJGJFKKHKJKJJBHGJKK4IHFKIKBKJJKCBJJEBKIKK8JGJIJKK/GGKK:IKJG4H<KHKCJK@KHK=JJKJ=JJJKKKGKIKJJHKKK(IJKIJFHHKKKFKDJJJDKJ?JKKKBKK5JKJJKJEKFIIHJKKFFABA@HKKKK3HJKJKKKKKKKKJKIIKJKKJKAKDKFIIJJKJG7?J;GKKAIKKKK;@KK%GJKKJHKKKIK=IJKJKJ>EJKDKJEKKEKKK-JKJKGKHKK/KJFKJKEKKKGKHIKFIKJIDJKKJKKJKKKJKIIIGIKKJKKKKBJKKKJKJIKGKKKKDKKKK:KJGKH?HKKIJEKKKDDKKKJKKDKKJKKJJJKKHIHFKJK=KHKJKDKJJJKKKKKKKKKK?KJKHKKKGJHJKJJJJICKKH4EKIIKKIKGKKKJJKJFKKKHKJKKHKKIKKHKHKIFKIKKJDIGKJJKKCKJJKJKJIJGIJHJHKDF?KIHKJJKKJKK3HKJFKKJKJKJIK9KHJEJJKKHKKKKIKIJKBHCIFG968KKJGBKIKDKEKKGJICJK?IJKJJK=KKKKKKKKGJJJKKKIKJJKGKHKKKKKKKJG?KJIKG+EHJKK:IKGKK3KECKJKIGKKK4GKK8IIKII'FIKKKKKK-HK4GAK>KJKKKKKKKGKKIKJJJIJDGJJFKK9JKKIKK9KKK0K @rCer/1624/1741_56_CCS ATGGGACTCCCAGGTTCCTCGGGACTCGGCGGGTCCTCCTGGGAGTCTCAGAGGGGACCGGCTGTGCAGACGCCATGGAGTTGGTGCTGGTCTTCCTCTGCAGCCTGCTGGCCCCCATGGTCCTGGCCAGTGCAGCTGAGAAGGAGAAGGAAATGGACCCTTTTCATTATGATTACCAGACCCTGAGGATTGGGGGACTGGTGTTCGCTGTGGTCCTTTTCTCGGTTGGGATCCTCCTTATCCTAAGTCGCAGGTGCAAGTGCAGTTTCAATCAGAAGCCCCGGGCCCCAGGAGACGAGGAAGCCCAGGTGGAGAACCTCATCACCGCCAATGCAACAGAGCCCCAGAAAGCAGAGAACTGAAGTGCAGCCATCAGGTGGAAGCCTCCGGAACCTGAAGGTGGCTGCTTGAACCTTTGGATGCAAATGTCGATGCTTGAGAAAACCGGCCACTTCAGCAACAGCCCTTTCCCCAGGAGAAGCCAAGAACTTGTGTGTCCCCCGCCCTCCTATCCCCTCTAACACCATTCCTCCACCTGATGATGCAACTAACACTTGCCTCCCCTCTGCAGCCTGCGGTCCTGCCCACCTCCTGTGATGTGTCTGTGTGTATGTGTGTGAGTGTGTGTGTTTGCTGACTGGTCTTCGTGGCTACTTGTTCGTGGACGGTATTGTGTTTGTTAGTGAACTGTGGACTTGCTTTCCCGGGCAGGGGCTGAGCCACATGGCCATCTGCTCCTCCCTGCCCCCGTAGCCCTCCATCACCTCCTGCTTCTAGGAGGCTGCTTGTTCCCTGAGACCAGCCCCCTCCTCTGATTTAGGGATGCATAGGGTAAGAGCACGGGCAGTGGTCTTCAGTTGTCTTGGGACCTGGGAAGGTTTGCAGCACTTTGTCATCATTCTTCATGGACTCCTTTCACTCATTTAACAAAAACCTTGCTTCCTTATCCCACCTGACCCCAGTCTGAAGGTCTCTTAGCAATTGGAGATACAAAGCAAGGAGCTGGTGAGCCCAGCGTTGACTTCAGGCAGGCTATGTCCTTCCATGGTCAATTTCTTCCCTGGGGCTTCCATTAGGAGTCCCCATCTGCCCCGCCCCTTCACAGAGCCCCCAGAGATTCCAGGCCCAGGGCTTCTACTCTGCCCCTGGGGAATGTGTCCCCTGCATATCTTCTCAGCAATAACCCCAAGGGCTCTGGGACCCTACCCCTTCCAACCTTCCCTGCTTCTGAGACTTCAGTCTACAGCTCAGCTCAGCTCAGTTCATCCAGACGCAGACTCCAGTCCCTGCCGTTGGGTCTCTGGCAGGCAATAGCTGAAGGACTCCTGTTCCGTTGGGGCCAGCACATTGGGATGGGTGGAGGGAGAGTAGAGGCCTTTGCTTCTCTGCCCACGTCCCCTTAGATGGGCAGCAGAGGCAACTCGCGCATCCTTCGCTCTGCCTGTCGGCAGTCAGAGCGGCGAGCGAGGTGGGTTGGATACTCGGCAGGCTCCGTGCAGCCCTTGGGAACAGTGAGAGGTTGAAGATCATAACAAGAGTGGGAACTCAACCCAGATCTCGCCCCTCCTGTCCTCTGTGTTCCCGTGGAAACCAACCAAACTGTGCGCTGTGACCCATTGCTGTTCTCTGTATCGTGATCTATCCGCTCAACAACAACAGAAAAAAGGAATAAAATATCCTTTATT + KGGK>HKKKKJKKGKJKKJKJKAIGKKKEKKHCBK=IGGFKKJHKKJKJIGIKKK9KKKKAJJIJKKKKJKKKIJKKKKJKFKHIIKKKJBJKIKIKJJIJHKKHKKKKKKKKKK6KKKHIKCKKKKKIKKKJKJKGJJFKCKKKIKGKIKKEKKJKKKJKKK:JHKHK=JIKKKK>KGKKKKKKJKIKKIKKKK=?KKKDKHKKKKKKKIKKKIFKKK=KAKKIK@KK?BEKIKKJJIIKKCKKJHKKKJIKKJKJKIKJIDKJKKJKKF?KHKKJJKKJ>JKFKKK?KKKKKKGKIKHKJKKKIJKKIJKJJKAIKJKKIJCKKKKJKAKKGKCJFKIGKKK@KIKKGKKJJJHKKKKKKFKKKK>GK@KIKKKEHKJKEJKIKKKKKKKKKGJKFKJHKFFKKJKAKKKKDJK2IIKEJHKK(EDKIKKKKJKJKKKKKKIKJKJKKEKKEKIJKKAJ8KKK1KKGKKKHJKKKJIIJKJKIIKCKKJKIKKKJKKKKCKKKEIJDHAKKKK?JJDECJCIIJKKK>CKGBKIIJKGKIIG@K:KKKKKKKKIDKAKKJKAJKJHKIEKDKKKKGGKJIKKK>IKHDKKJKKKKKKKFIGD>DCEHIIJJKJKKKKKKKKKIIKKKKKFKJKFGKKKBJKKGKJJK?JKKKKGKKJJKJKKFHKKJJKGKJKKKIKKJCHIDK7HKKIKHGKKKKJKKDKK:KKIKJKKK?JKIJJKKKJFKKGKHGHKKKFJJKJKK@GIKKKB5IJCHKK4JJK@EJHKIJKKH>FJ:KIEB:JH@DGFGK@KKIKKGJKKJJKGGKKKJK(JKKHKGKEHH:CKJGJ@DA<@KHI;FJBIHK>DKKKJKHKIKKFJKEKGKKIGGKKCKK>KKGIKK?KJKFKK2H@FHIGJKKFJH?KHKKKKKKKJJKK=JBEKEKJ?FJKJKJKKCKDJKKJK,KJKJIGKJKKHKJFJKHJKIKJHKKK>KJJGKJKIK@KJEHKHGKGK=JCKJJKJKKFGJ?IJHBKHGKJHKKCKF8JK?JKKKKJIEJKJJJK=KKKIKEAIKHKIKGJG>JJIKJKJKKAKKJKKJKKKK=JD9F5JIFGKJJKKKKKJJHK;BKKKBKKKKJKJKIKEKJHKKHJ:KIJKJKHJ@KKHKKAJKKJIKHKIJKIIDJKKEKGKKIKIJCJKD4IJIIIHCB6K6KIK;JJKJKI.KKDF4KJKJIKKKHIIJ58AFK8C@JIKJKEK=JKIKJJGKIJFJK9KKKII=KKJ?G:KGID<3HKKJJKFJKK?JKIHDKIKKJKCKKFCKKJJIGHIKKBKIIKKKKDKKIEKHKK>KKKKFIKKKEH;JFJKKJJH9KJKJHKKKJJKKFKKIJKKJJKJKJKKKKK@JHJFHJIKCH@K>J3KAJDKKK=C4>IIEKDHIKKCGK3HJJCIKJGKJKKKKKKKKKKJKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKBKKKKKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKHKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKJKKKKEKKKKKHKKKKKKFKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKJKKKKKKKKKKIKKKKKKKHKKKKKKKK;KKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKJKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKHKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKK$KKKKKKKIKKKKKKDKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKK9KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKJKKKKKKJKKKKKKKKKKKKKKKK @rCer/1631/25_2867_CCS ATGGGGCCGCCGCCTGGATGGGACGCGGGCTGCCAGGCACCCAGCTGTGCCAGATGGATGGGACAGAGACCCGGCAGCGGAGGCTGGACAGTTGTGGCAAGCCAGGGGAGCTGGGGCTTCCTCACTCCCTCAGCGCAGGAGGACTCCCTGGAGCCTCAGAAGATGGAGCTCTCAGGGCCCCTGAGAGCCAAAGTGTGACCCCCAAGCCACTGGAGACTGAGCCTAGCAGGGAGACCGCCTGGTCCATAGGCCTTCAGGTGACCGTGCCCTTCATGTTTGCGGGCCTGGGGCTGTCCTGGGCCGGCATGCTTCTGGACTATTTCCAGCACTGGCCTGTGTTTGTGGAGGTGAAAGACCTTTTGACGTTGGTGCCGCCCCTGGTGGCTTGAAGGGGAACCTGGAGATGACACTGGCATCCAGACTCTCACAGCTGCCAACACTGGACAAATTGATGACCCCCAGGAGCAGCACAGAGTCATCAGCAGCAACCTGGCCCTCATCCAGGTGCAGGCCACTGTCGTGGGGCTCTTGGCTGCTGTGGCTGCACTGCTGTTGGGCGTGGTGTCTCGAGAGGAAGTGGATGTTGCCAAGGTGGAGTTGCTGTGTGCCAGCAGTGTCCTCACTGCCTTCCTTGCAGCCTTTGCCCTGGGGTGCTGATGATCTGTATAGTGATTGGTGCTCGAAAGCTTGGGGTCAACCCAGACAACATTGCCACGCCCATTGCAGCCAGCCTGGGAGACCTCATCACACTGTCCATTCTGGCTTTGGTTAGCAGCTTCTTTTACAGACACAAAGATAATCGGTATCTGACGCCGCTGGTCTGCCTCAGCTTTGCGGCTCTGACCCCAGTGTGGGTCCTCATTGCCAAGCAGAGCCCACCCATCATGAAGATCCTGAAGTTTGGCTGGTTCCCAATCATCCTGGCCATGGTCATCAGCAGTTTTGGAGGACTCATCTTGAGCAAAACCGTTTTCTAAACAGCAGTACAAAGGCATGGCGGTATTTACCCCGTCATATGTGGTGTTGGTGGCAATCTGGTGGCCATTCAGACCAGCCGAATCTCAACCTACTTGCACATGTGGAGCGCACCTGGCGTCCTGCCTCTCCAGATGAAGAAATTTTGGCCCAACCCATGTTCTACTTTCTGCACATCAGAAATCAATTCCATGTCAGCTCGAGTCCTGCTCAATGCTGGTGGTCCAGGCCATCTGATTTTCTTCTACATCATCTACCTGGTGCAGGGTCAGTCAGTCATAAACAGCCAGACCTTTGTGGTGCTCTACCTGCTGGCAGGCCTGATCCAGGTAACAATCCTGCTGTACCTGGCAGAAGTGATGGTTCGGCTGACTTGGCACCAGGCCATGGATCCTGACAACCACTGCATCCCCTACCTTACAGGGCTGGGGGACCTGCTCGGTACTAGCCTCCTGGCACTCTGCTTTTTCACTGACTGGCTACTGAAGAGCAAAGCAGAGCTGGGTGACATCTCAGAACTGGCATCTGGACCTCCCTAACTGGGCCCTGCTGGTCCCATTTGCTCATTAGAATTTCCTCTCACATCAGTGAGGTACAGAATTCAGTTTCTCCCTTCCCAGGTCCTTGGGATGGTTGACCCCTGCCTCTGCAGTAGCCTTTTGTGAGTCTGCTAAGGTAGCTCTCACACACCTCGGCTCTGGGGTTGATACCTGAGCCCGCAATAGAGCCCTGAAATCGAGAGCACAGCTCGAGTGTGTGAATATGATGTGTGCACATGCTTAATGAACGTGTTTGAGTGTGCACGCGTTTGTGGAAAGGAGGATAGTCTGGCCTGAGAAGCTAAAGAAGAGGCATGTCCAGTGTGCTTTGCAGGATGTGTTTGCTCCTTTCCATTCCCATGCAACCCAGATTGGGGTGGAGCAGGAAGGAGCTCCTTTCTGTTCCCAAGCCTCAGGACTCTTGAGCTGTGGCTTACTTGCTGGTTCAAGCTCCGTGGGCCACGCTGCTGCTGTGCCAAGAAGGTGTACAGCCTCCTCAGGATGGGGCCTTGTACAACCCTTCATCTGTGCTAAACATTTGTGTCCTAGCTGTCTTTTTATTTTCCTTTTTGTTTGTTAGCAAAAACCTCTATTTAGATTTCAGTAATCACAGAAGTGTAAAATAAAACATTATATTGTACTTGACTTTTTATGTCTTTAAAGATAGTTAATGCAACCCTGAGGCTTGGGGTCTATAAATAACAAAAGCATCTGGCACTTCTCTAGTTCAGTTTTTCTCAAAGTGGTCTTCAGCCTAGAAACATCATTGTCACCGCAAAACTTGTTAGAAGTGCAAATTATTATCCCTCAGCCCCAGGCCTGATCAGCCAAATCAGCATCTCTTGGGGGTAGAGCCAGCTATATGGGTTCCACAAGCCCTCCAGGTTTCTCATGCACACCCATGTTTGAGAACTACTACTCGAGAACATCATCTTTAAAAAATGTATGATCGTTTCCTGTCTCTTACTCGCTCATCAGTACAATTGTAGCCGTGCTTGGGCCTGAGGATTATTATCTTCATGTGGTAAAACAGACATCTCTTCATTTATTCAACAAATGTTGACTTGTTATCAATGTTCTAGAAGGAAAGACATGGTGTATTAACTGGAATAATTGAGGAGAGTTTAAGGAAGGCACAGTTTATAGGTGCATGGGGACTAGAAGAAGGGGTGAAGCATCCTGGGGCCAAGCACTACCAGATATTCACCTGTCCTGGAGAATAGTTGGAATTGTGGTTGCCTGAGATGCATGGGGATCTGTAATAAAGAGACACAGCTACATCAGCTTGTGGCCTGGCAGAGAAAGCCAGGGAAATAAATATCCCAATC + 6+1=<8587+7=98597493=>3;=='9&+273<;<=091998=;:=<6$;7:;;5:7:4?;699<=6<-<=69=9<>>;8;?493;8:6>9?974=23<;14+.8=;;55=);9==><:=>>=8:,><;:<<>>??>:<1>182/:?>9>8<=77?;<186,;8?9988==>;)9=)67:=>:6<<9?8?>88>=>3'98776>8:=>>>66:79>;7:967;<==8.:<9504;=;?>:?>2>27<8:.<9?><1:4=:4?9=<3;>3:86689;>8=<76=9:8<0=;::7>;2:>>?:<6531+5;<2)<<<=/;:??;22=5?=>;>:86?7;3=<;5)7<>>1928<<7<;3;?9:7=?>?<*793#-4:78:;6?1?383/9?<;8=>):98:2:,>>><=/=30;>=69=;;:=8=7<>7;>9==5;5:85=4>>99<<;;99915986/,8089>86:;+6;99>;5>;9<2;37>=;?>6=::<6>/7:6>%9547/0:39478>509,288>::-795<4:968+<7:;3:7<49;<;69?8;;1<>5/,:<>=;:74<6;9?9<95>:-5.8;90>=8&5359<:29.67>=>2;:0<8>;;=366?>7<7762<7673>)88;386=:9=8>=;=?<3886176;75;:,699=727?9835:*=5-,//:<8;?><>9>=;<2=<4:;7:9=1;:8>=>=88;>=29;>95=6;6<:=,986=<?775886>9?<;?;=6:7=879>6:.;87366B:BBA@@BAC9?@;:=8==7@6?18:1B>>>A==;:6<;;<=7?CA@@=>=A@B2>AB6;<<(=@;<>6>A<=AB;5<;A5BB4?:3,0:<9>05(1(*%-3:<<:@88829.,98*?:A@7CA7B66?B@A@C?AB=<4;AB:AA:A>B?CAC)@BB>=@@=;BC?B<>C?=AB<=:;;6B;AB7B;93B824>BA?=6>3@A=BA>?@B?C=CB6@AAA>739=A<5;9CB@>=@@=;7?7:;CCB9ABACAB?>>@B===6>:=9;0>ACAA9$489?B>B5;B;*;<6B:BB:7;:@6BCB@:=<92=?<;)=BA?;@=>A?BA>1=:>B@449A>A89=;AB=?@':A=;>B0=:7>3=:??9=;;9C9><9=C>:8?-==?6?BC?7B@8AA6>99@<>:@C65;>C>@:B=65><>16,??A=:=B?A@%?<7:<5@7A>CB3@>97'=>;@B@A;?4259@B=A<7=>A>@:;@C;?;<9:<9.=>CB?@<@?69C>B>8;8@C9A;;@B;AA=A=@8A=?A>>ABBA@?A;;7:A<:=A>8;;3;BB>CB28>B:BA?B:?7=A0??A;>>=ACBBA@B;5>&??1<7>;87?8BA?:A(>B>B5?>:<3;<8;6=B@9@6*/4B1B@??7957=C@:;@@@A>$6:7;BB@@?@>@@;A>;9;;@C@0@7;9<3;;>;BBAC=9@=A>>4<>>AAC=>@73:A98>)8:;@99*86;?A?CBCB=;<==C>;:@<>A@>;635=?>:?==6>AAB>=CCC??BA<=4@.@><@A4<.6:;;;@A@8BBB>A4BB?82@A:1<;<9B?<;@@;C>;>:<>=.AA<==1>;9<=;@AC?;;?C=C=89;4=8=.:@@BB/=2<@@>8<4@<6;@@C<9;9.7788>=:@@*;8>:5@B7BBC@4?56>@6=<):CB59?C6=BB@=C7@B9=2??>786:;BB8=@=*B-5>98=*<>>?>B:?A@9=05;=9?0;6>A:AB?>AA?::<86;B>A5<=;9867@>5B5>73.0><945/;=>=A2B@@A9/=<<:B<8<.?AA??CACAA:BB9A@0>;<:<80<@ABB9CBC427:8BB;A.@@=7;>@;878;;A==6:;<=9BAAA98A6=.?@;90>>AA@C@=C?@A(=<:<=:994A=8<>9.;>?=@?AAB>C>@B:><%38B=;?4A=;><>:0>?A=B8335%8@;6>A?/=2A6;?7@=.<=7@@4@6@*88<:83+9@><;A9<@@:A=A<:A:AA4>:>=C(?>=73.8A<@?@70?><=>5?@7A;?@@5?;=@CA4??=B-@?5=A>@::?><6ABA9<3CA9@99>>C?AA>>?;>@A?@A==>;1;0>;.=@?A>>A;7;>BA?<:CC?AAC?BBA7;6:6262;<=><99?<>AC>B@?>=+>=>AA0@&;;,=?BB7;?49;0-0A>>@@A:C?:;?@3=C?9@?4@?=@8C8>?8@A6A=?8;:88*@;=A;1@=97@>C@B@==CAB?87<>;>>?>>3&=;;;<:(@>==;8><1:/6=5>;764;>=<8,667(082,2+2763;<>5==<:<84<=:26:>=6<9*47;197;;967>/.4<;67=299:=89=<966;/5)65468679/:::18:58871*71=99<>=9=8=:7:=5+/5?:9?<0:289><:6>87>7+<>8,:4045(983:99 @rCer/1632/285_56_CCS CCCCAGTCCCCAGCCAGACCTCCTCATACTCCCTGCATGCTGCCACCAGCCCTTCGGTGAATGGCGAGTTATGATACCTACACCCCCCCACATATGCAGACACACATGAACAGTCAGCCAATGGGCACCTCGGGCACCACTTCAACAGGACTCATTTCCCCTGGTGTGTCAGTTCCAGTTCAAGTTCCCGGAAGTGAACCTGATATGTCTCAATACTGGCCAAGATTAC + 2/-&.(..,/&(11')*+)$/,+.-'*---,.%.,0.&/2'&.&1()2*/'+4*.*&39.&/3')$0040&775306*.121169770'31281:6637==9/22529=5897,74*)&9297>0;5:08=;;959?2//7(;=:@?>976.99<869747@??69<=A274=AB9A;*>;<18,5,208@5.%/&36(0-7;9.9<=2259;=6=5-&1.+**4 @rCer/1633/26_2131_CCS ATGGGATGGCCAGAATCCAAATTGTAACATAATGATATTTCATCCAACCAAAGAAGAGTTTAATGATTTTGATAAATATATTGCTTACATGGAATCCCAAGGTGCACACAGAGCTGGCTTGGCTAAGATAGTTCCACCCAAAGAATGGAAAGCCAGAGAGACCTATGATAACATCAGTGAAATCTTAATAGCCACTCCCCTCCAACAGGTGGCCTCTGGGCGGGCAGGGGTGTTTACTCAATACCATAAAAAAAAGAAAGCCATGACCGTGGGGGAGTATCGCCACTTGGCAAACAGTAAAAAATATCAAACTCCACCACACCAGAATTTCGAAGATTTGGAGCGAAAATACTGGAAGAACCGCATCTATAATTCACCAATTATGGTGCTGACATCAGTGGCTCCTTGTTTGATGAAAACACTAAACAGTGGAATCTTGGGCACCTGGGAACAATTCAGGACCTGTTGGAAAAGGAATGTGGGTTGTCATAGAAGGCGTTAACACCCCTACTTGTACTTTGGCATGTGGAAGACCACATTTGCTTGGCACACGGAGGACATGGACCTTTACAGCATCAACTACCTGCACCATGGGGAGCCCAAAACTTGGTATGTTGGTGCCCCCAGAGCATGGCCAGCGCCTGGAACGCCTGGCCAGGGAGCTCTTCCCAGGCAGTTCCCGGGGCTGTGGGGCCTTCCTGCGGCACAAGGTGGCCCTCATCTCGCCTACAGTTCTCAAGGAAAATGGGATCCCCTTCAATCGCATAACTCAGGAGGCTGGAGAGTTCATGGTGACCTTTCCCTATGGCTACCATGCTGGCTTCAACCATGGTTTCAACTGTGCGGAGGCCATCAATTTTGCCACTCCACGATGGATTGATTATGGCAAAATGGCCTCCCAGTGTAGCTGTGGGAGGCCAGGGTGACCTTTTCCATGGACGCCTTCGTGCGCATCCTGCAACCTGAGCGCTATGAGCTGTGGAAACGTGGGCAAGACCGGGCAGTTGTGGACCACATGGAGCCCAGGGTACCAGCCAGCCAAGAGCTGAGCACCCAGAAGGAGGTCCAGTTGCCCAGGAGAGCAGCGCTGGGCCTGAGACAACTCCCTCCTCACTGGGCCCGGCATTCCCCTTGGCCTCTGGCTGCCCGCAGTGGGACGCGCTGCCACACCCTTGTGTGCTCTTCACTCCCACGCCGATCTGCAGTTAGTGGCACTGGCCCGCAGCCCCGGCTGCTGCCGTCCACAGCTCTAGGAAGCCCAGCTCAACTCCATCATCCACCCCTGGTCCATCTGCACAGATTATCCACCCATCAAATGGCAGACGTGGACGTGGTCGCCGTCCTCAGAAACTGAGAGCTCAGGAGCTGACCCTCCAGACTCCAGCAAAGAGGCTCCTCTTAGCGGGCACAACATGCACAGTTTCAGGCCCAGAACCTGAGCCCCTACCTGAGGGTGGGGCTTGATGGACAAGCCTGTACCACTGAATCCAGGGCTCCAGCATCCTGTAAAGGCTTCTAGGTGCAGCTGGGCCCCTGTGCCCTAAGCCCACGGGCTGCCTTTATATCCCACTGCCCTGCTGTGTGGCAGTTTGATGAAACTGGTTACATTTACATCCCAAAACTTTGAGTTTGCAGGACTCTGGTCATGCATGAAAGAGCCCCTCTGGTTGATGCCCTTGGATGCTGCCAAGTCCATGATAGTTTTCAATTTTGCAATACTTTGTTCTTCCTACTGGACCCTGGAATGTGTTTGGATATTGCTAAAATCTATTTCTGCAGCTGAGGTTTTATCCACTGGACACATTTGTGTCTGAGAACTAGATCTTGTTGAGGTTAGCATAACCTGGTATATGCAACTACCATCCTCTGGGCCAACAGTGGAAGCTGCTGCACTTGTGAAGAATCCTGAGCTTTGATTCCTTTTCAGTCTACCCATTTGTCTCTTCCCCTCCCCTACCCCCTTTTTCTTATAAAACTAGGTTCTTTTTACAGATAAGGTCAGTAGAGTTCCAGAATAAAAGATATGACTTTTCTGAGTTATTTATGTACTTAAAATATGTTGTCACCAGTATTTGTTCCCAAATATATTAAAGGTAATCAAAATG + ,)(-(((-.-.,*-.)(-(,-+.+++*)*(%)*(),*$,(%*-)-,.(+(*'((,(,--..,.-),&-,+++0&--011/-11--0/00/-1*.0,11/2/2+,/.)'++/11,(-01.0*,1112,010,02/2,0-2-21112.(&'/1,*/.,,.00.*00,-./0()/,,000)0-221.-01/11/121,1+1110-1%+../2,1212111,200.2211+1-/,/,12111110,..0.1&,-//0--.,.11,21/11.1,,%.//&$%,1101.2.,-2-21*01111,(.1100-*0,(.-0,-10,001(.211.-%,-0-.110'00..0-/1,,010,0000+,//212(01110,#',+01,02./'10112/+01-+-+'-111,..1-1$,*).00,,01222001-)1//11+,'+.-102'10..*,*,.210112-20.00-.211&+*-(.11-2-0--+#,.'/,+0111.%+,-+/,0*,-,%$,0-11-,***-*/0(,*)*.1,0*1,-00-./-021-.0,1.%)01*21/2*,,.+..12-2-.1-1/11*-20,**0&/0).111,0101-,21*121/'.-1,/--&')-.-(0/0./,(,-10-0/21+,102-/)'.01*1&,2/2/+101111,-1022112-01-2-22%/.-,/0.-2.2-2+.-..110,.10--),+*+#)(*-1111,0&.-.111000.-%*,2'-011+2+/$(*/.-.0'--,,00102,'/1.00,0//,01-10+0011.211-02122..0&,*,-**-02&+1(&)0012102,0.+*-(/-..211-*0+-0..0-10,012)1001*0,10-.-1.1+&0/0011.0.)/21*22210/.2/%/.,..111/1-//$0--'+,2-1./11010%)0//2--*00-**,'./0-.110,,(,/-0-11011.0.1//-0/-0001..1'01011,/10.1--100200-,&-/0020--111.0,1*-1.*#&*,012,112-0-2%-/-1.1-.-.10,011(0001).,-201,10&//+/*11,&010,/0+./212--,/11.2/0.21)-/+..1'&,,+-1/20-12)11/.0-0,1)0..01,/,220/-01'0-./-&*,,)&'+-,+1/,2.1.,0'/0020'0-,-21/+-211-*+-11/-10111.+**1..$+).+$%*,,()-../,0/,0/,+101,0.0-)0-0+0,-00011.0'-/10/1,0',-21)1--+1/1.0101.1/,0251)0.3'/&&(.02/3561455-14513-4-3/1%040346623602+2',12123/./6365/1&-&).-*-..+--,-++-/'/-()'3111,*%3.00.5340225,2024,0444610&43,///&112602*212.406463.34+00++10'0000$2,').31//.++111./-54344055160+1-**)4244)226/2'&-/-054640/),,,,/)./024/45615543625-14-4655030)$105//1/22--/231204022644150/-4202&0,.0.42556655*./04.231315166*4545,321.2-6612/$303.0--3131/4521.22451*+56521225&25334436-5-53.2/01/3+510-2*131,32.6510-3-2646656.151562-0546-4/45.,/0/45656/1.12-*64,0+/41/566455644./1453623644)2156)04244.156516436/2*43)/420/265)32146.50-45263655.53450)2456115-.2,'/40225..5223704/-::88((,98.1=:=1:42-25951.5889;?=:==;=<>>;85==<;:<93/:=:9;8>=5%7:8.,6;9:869273=>70398;79/5346*26172&7247:6980549195(378787598545.5,5820$430092:9637-%265446479432693563798;137:57::53.7'15+--0(-03-44534962-019+./946:9667729/::79.6;46&6722/ @rCer/1635/21_1815_CCS TGGGGGTCTCATCGCCGCGCAGCTCGCATCTTGTCGTTCTGCCGCTCACTGTCCTAGTCCTCCGCCGTCGCATGGAAGAAGAGATCGCGCCCTCGTCATGACATGGTCCCGGCATGTGCAAAGCTGGCTTTGCTGGGACGATGCCACCCGAGCCGTGTTCCTCCATGTCGGCGCCCCCGACACCAGGCGTGAGGTGGCATGGGCCAGAAGGACTCCAGTGGTGACGATGGCCAGAGCAAGCGCGCATCTGACCTGAAGTACCTATTGAGCATGCATGTCACACTGGACGACATGGAGAAATCTGGCACATACTTTCTACAATGAGCTGCGCGTGGCCAGAGGAGCACCCGGTGCTGCTGACCGAGGCCCTCTGAACCCTAAGGCAACAGAGAGAAGATGACTCGATTATGTTTGAGACCTTCAACACCCGGCCATGAGTGGCATCCAGGCCGTGCTGTCCTCTACGCTCTGGGCGCACCACTGCATTGTCATGGACTCTGGCGACGGGTCACCACACGGTGCCCATCTACGAGGCTACGCCCTCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGCTACCTCATGAAGATCCTCACGAGCGTGCTACAGCTTCACACCGGCGAGCGGAAATTGGCGCGACATCAAGGAAGCTGTGCTATGTCGCCCTGGATTCGAGCAGGAGATGCCACCGCCGCATCCTCCTTCCTGGAGAAGAGCTACGAGCTGCTGATGCCAGTCATCACATCGCAATGAGCGGTTCCGGTGTCCGGAGCGCTGTTCAGCCTCTTTCCTGGCATGGAATCTTGTGGCATCCATGAGACCACCTTCAATTCCATCATGAAGTGTGACGTGGACATCGCAAAGACCTGTATGCCAACACGTGCTGTCTGGTGGCACCACCATGTACCCAGGCATGCGACAGGATGCAGAGGAGATCACCGCCTGCACCCAGCACATGAAGATCAAGATCATCGCACCCCAGAGCGCAAGTACTCAGTGTGATCGGTGGCTCCATCTTGGCTCACTGTCCACTTCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGCCCTCCATCGTCCATCGCAAATGCTCTAAATGGACTGAGCAGATGCGAGCATTTGCTGCATGGGTTAATTCAGAAGTAAAATTGCCCTTGGCAAATGCATAACCTCATGCTAGCTCACGAAACTGGAATAAGCCTTTGAAAAGAATTGTCCTTGAAGCTGTATCTGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACGTGTATTCAAGTTAACTGTTCCCCTTGTGTTGTTTAATACCCTGTACATATCTTTGAGTTCAACCTTTGTACATGTGGCTTGGTCGTTCTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGGTGAGTCGCATGCCAGCAGTCTCCGATCTGTGCAGGTATATGTGTCAGGGCTTGAGTTCTGGGATTTCTCTAGAGGCTGCAAGGCTCCTGAACCATTCTGCCCTGCAGCTGTCAGGGTTGGAAAGTCCAAGCCAAGACCCAGTTTTCTTAGCTGACGTTTTCTGCCAGAACACCGTGGCTGTTACTTGCCTTGAGTTGAAGCGGTTTGCATTTACACCTGTAAATGTATTCATCCTTTTAATTTATGTAAGGTTTTTTGTACGCAATTCTCAATTCTTTAAAGAGATACAACAAATTTTGGTTTCTACTGTTATGTGAGACATTAGCCCCAGCAACACGTCATTGTGTAAGGAAAAATAAAGTGCTGC + "#%%%%$$#$$#%%$%$###$$$!"'$(($%)$&'##'($''(&$'"$&((($''&(%$(($($#%"#&''%'()%($%((($&(##''$$'(((%'('%#%$&$&#$'%#&###$'#$$%(((%()(())('##&&&%#$&'$(%$''$(&#''%##$%)&#'$&#('$('(%)())'#%#')'#%&'((&"((&)&%&$&(')(($%#%&%%%$#"$#'''(&$(#$%&-&*)+,+-&(+(&+**%"&((-(+&'((%(-,,*-+++&$#$#&$%(*+($++$/.,+/)01-..(&.00.,(/-+'&0,.*21&+0+/2,**%+.)(%*$&''$--0/+1,,/,'/1'-10-/$)**/)100(,""+)(.-/2&0.-(+#'($-*,&+',($.&*+&)'+,#)$--+.,20,+%/.2.20+//+%00(/%,(-*#$*-.%.-,.),.,3.200)+1$2,/.)0**,%/%0++0.,)/44425/+234354-6/.),1(100,/$.,,(&-6211/%./*&)00.+403.'%13450-#0+#%-00/2',55.*115403/0)402/*-5&3(3)0)52.*01/('32)///24412-)2'.3-6+10&-31.(,)$&,/.4/'/+)&&#$&,+.,1.'2,.2/4)#,-4.03),+$*$$&+$,/#'+053-/0*4/22005)#04.))251/4313#%24462&24025462*''-#,215*.'.&,(/053/0)%(,#003,('0+#.0,(-+%)/.$-(2.2201(4-4(4)11,+'4+*((444)0).+1)&1-,,3/050(2/35-4/62405+0'2-14(0.4*)%2(1+.5/4+)5(2-610251/)3/1-3)2243-6-(+*$((&20*,)1.2/*-,%+*5/-*$.02/5151,32(51/'1)%0,0&/,(.10(440++--*1)032&32.2&)1*#(201*0*(4+%-/'34-3*,+*/21323/0/6/4154+/3.-%434,-21.20.4/14-114333(%(0,+*,*12.%.'*-'0(&$.0/*,./-3*$'%%2401.3%/0,3*/6323*5/(1&21.423).44%2*3,2$+.*''&/50./6)*(24/621-'&,()32/131/)/32(..255/)%(.1.44.0(3,)3%30*3)5'40)/*/.*(*+.)+-*35&3)24(401553*-*(34223*'*02'13.)&%41(+,5064(2-(1'240/6654*1.155%'+51044-*(-01,/,4552232+15.+00(1034-(54%30/4)-)15-00-(.%.1310*22,6)34364,406'//)&+$'-#($#0/+11)*01-111+..+-*(/11./$+-+0&0000$.'%-10.-2,02----/'/(#'./*%(%-,011-1-')&*(*+'%.*0.,-*-'$+,'/0'0(1//+,/)"(10')+&00-.,-/%/+*%1.*,-/+&0)$'()'*(/-/&0/0'00.'*&$'$().&/,(*.+,0-021.(,$+(.+--0-+%.-2/$0$,(/221.''.#('*+',20'/%.*.1,0*1,.0(.-&')#+.+/)100/*1.%$-&-,)&/+*,)%+-./*0.*)+)0&.',/*.+--.0(//1+/)*/,(///&,*2.+--(.,001020--(.0/0.1-21/)--)0/1/1,0//-10+0$'$,///-%,//0.*/*1/-1.-121-0/&),00,*+*/*/+&-/&,.-/0&-1)''+,('0.%0*.+##(.+&$&$*++.(0%,,.+)+**(0,/,0,1%)%/0/,*)00,1.010, @rCer/1636/665_60_CCS ACTTCGGCCAATAAGATCCACACTTGGTGTCCAGCGGCAGTGGGACCATGGGGGCAGCCAAAGTGGACTGGGGGAAGTATGGACATTTCTAACCCCCGCCTGCCAAGAGTGTGGAAAGACTCACAGGCGTCAGCATCTCCCAGGTGAATCACAAGCCTTTGCGAACAGCTTGAGCCTTCAAGCCCCTCACAGATGCCCAGCCTCATAGCTGAAGTTGCCTGAATGATCCTCCTGTTGATGTAAATCCACTGGCCTCCCTGAGCATGGTCCATTGGACAGTGAGGTTCCCACCCCTCATCTCTCTCCTTGCCAAATAGTTTGTGCCTTGTCTTGAAGGGGGTTGCTCCCCTTGCCAACCTCACACTGCTATGATTGCCAAACTCCAGCGGTCCCCATGTCAGCCTTCTCTGATGATCCCACTCCCACCCCATCTCAACTTATTTAATTTCCTAATTAAATCAGACTGTTGGAGCCTGTTGTCTAGAATACTTTCCTGACCAAGACTGAAGGATGTGCTGGAGGTTTTCAACTTTTGCTACCCAAATAAATTGCTATAAGTAAGTACTGATACTTATTCAAACAATTAATAAAACAGAAGCAACTGG + $)+*),#*$(#*)$((%&$((&)%#'%)&&))+'%(%$$&%'($%-+--.+--'&%*+$++##%(&&+'(*+(#+#$$"(,('(&%"#(&&*)'#&#&+*)%,$#&$))''',&+,&()('+#'$*%**($(&%(+&&,-(+,'(*'$+,'+-)$+'-,$(*(+&*)&',+'()*,($''#*+,($&&'&''%))+&$)&,((%,+-(&$(,&$**')$)$&'&,)',&&+(,+-&#(&(*((#$*#,.-2-2.)+,$''($($--$).++-$&%-/(0+.'(%%%./*$+.0+/0-+&(+&##*(+*$,,/'$'*((.$2./3-0(*1+3$11*265-$-'*)*431+/$%.*3+0)%),,)*'40'.1)./(/4).4+413(0410.-.11&52--,,)4&).&$$,*.)*,)/4&/-+,&")/-0%421+21&10+0,.(++-0&4.+3-321-%$/-'/.,,/#+'($.)++.*-%.-/)-)),.1/%*%&(+/+/%)*,'&,(1,+)-%-%+2.$/.0/1),,$./0/'-)+&--(.1+//,&1-,.()(-&.00)%(++.(($&-0,'''*+.$.2,0)0,'-10&./+0+))/,-(0* @rCer/1637/25_1576_CCS ATGGGGGCGGCTCCGAGGTCGCGGCGGTCGCAGGATGTACACGCTGCTGTCGGGCTTGTACAAGTACATGTTTCAGAAGGACGAGTACTGCATCCTGATCCTGGGCCTGGACAATGCTGGGAAGACGACCTTCCTGGAACAGTCAAAAACCCGGTTTAACAAGAACTACAAGGGAATGAGTCTATCCAAATCACCACCACCGTGGGTCTAAACATTGGCACTGTGGATGTGGGAAAGGCTCGGCTCATGTTCTGGGACTTAGGAGGGCAGGAAGAGCTGCAGTCTTTGTGGGACAAGTATTATGCAGAGTGTCACGGCGTCATCTACGTCATTGACTCCACCGACGAGGAGAGGCTGGCCGAGTCCAAGCAGGCGTTCGAGAAGGTGGTGACCAGCGAGGCGCTGTGCGGTGTCCCTGTCTTGGTGCTGGCCAACAAGCAGGATGTGGAGACGTGCCTCTCAATCCCTGACATCAAGACGGCCTTCAGCGACTGCACCGGCAAGATCGGCAGGCGGATTGCCTGACCCAGGCCTGCTCGGCCCTCACGGGCAAAGGGTGCGCGAGGCATCGAGTGGATGGTGAAGTGTGTCGTGCGGAACGTGCACCGGCCGCCGCGGCAGAGGGACATCACGTAGGCGCGGCCGCGCTGCCGTCGGGACGGCTGGTGCCCGGTGCTGGAGGAGTGGCCTGTTGGCTGCTCGTCTGGGGGTGGGTTTGCTTTGCTTTGGGTTCTTCCATTTCCTTTGTTTCTCGAAGACAAACTTTCCTCTACGTCTGGAAAAGTGTAGGCCTCGGAGGTTTTGGAGGGGAGTCTGGCCGCCCGGCTAGCGCCCTCTGGCGGCAGCCTTTCCATGGGCGCTGCGGTGGCCTTTCTGGCCCTTTCGGGGGGTCTGAGGGAGACCTGGTTGGGAATTGGGGCTCCAGTGCTCAGGCTGGCTTGGACTGCCTGGGGACAGCCCTGTGGGCCTTTGGGAGATTCCGTGGCTGCATGTCCACCCATCGAGAAGGAGGCCAGTCAGCTATGGCTGCCCTCTGGCTTGTGCCCCGTGACCCTGGAGGTGGTCTGGGGCTGATCTTGCCTTAAGGAAGACCCAGGCCATGTCCCCAAAGGCCAGCGGGGGCCCTGGATTCTGATGCAGCCTCGGGACAGAGCCGAGGAGGCCTGTGAGGGAAGACATACACTCCGCACCTGAGCCTGGCTTTGCCTCATCTTAATCCCTGGGAGGGAGCTGATGCAAAAAAGCTGAGGGGCCTCTGCTGGGAGTGGCTGTTTTTGTGCCCCAGTCCTGCAAGTGGGGAGTGTGTGGGGGGTCCAGAGCCCTCTCCCAGCCAGGAGAGAACCTCCTGGAGGGTTCTCTGGGGGCCCTGTGTCAGTGCTGTGCGGGGCCTGCGTCCCCTGCTTGGGAGTGAGGCTGATCCTGGGGCCCTCCCTGCACAGCCGCCACTGGGCCTGCTGAGCGCTGTTCTTCCTCAGTCTGGCTGTGGGCAGGAGCCGCCTGCCCAGTGCTGCCCAGAGTGAGTGCAAAATAAAGACGGCAAGTGTGGGTCTG + KK+KKKKKIKKKGKKKHKKKKK@JKAKKKKKJHKKKKKJBCKKJKKKKKKK9KKKJKKKKKIKKKJKHJKCKKKKKJK2KEJKFKKKKKKK?KJKKKKBJKK.KK;KKGKIKFKKHK>,KG>KHJKKK9KAKGKJ9KJKKKKKIJKKKKIKKJK5KKHKKKKKEKKKKKJK,KKIKKKKKKKJKK@8%KKKKD8II4KA5GIKKKKKKK=KKKKBK8KKKKKKCJKK=KJKKAKKKKKK;IKEJJKKKKKKAGK,KKKKJKIKGKKKKKJK6KKKKEKIKJKKKKJK=KKJKKKKKCKJIGKIKJ>KKKKKKKKK?KKIK=KIKKKKKKKKKKKKKJIK@KKKKKKKK=KKKDKK$KKIKK@KKKG/KKKBKIKKKKHKCK>KKKKKK4KKKJKK0KKKKKKKJJ=KKKKKKKKKIKKKKKKKHKKKKKKKKKKKK;KKKKKKKKKKKKK?KKKKKK2KKJKDHKKKKJKKKKKKK>KKKIKK@KKKKKKKKKKKK1KJJKKKKJKKKK=KKAKKDKBAKJJKKKK8K;KKKKKCKJKKKKKKKKK+KKKK=7KK)KKKK1KKKK1K1+KK@KHKKK=KK>K?KKKHKK8KKK:2KKJKK8KK&KKKKJDKKKK&KKHIBJKKDKEKKKKFKKDKKK(KKKKKIKJKKKIKGKIKKFK,K&IKAKKK+KKKKKKKJKK0KKKFF?KKAKHI&FKKKKK>K*KJKK7K4K@KKKJ:KKJKJKKKKFKKKJKJKKHKKKK3KKKKKKKBKKJ6KI:KK9KKKK.KKKBDKKK@IKKJKJKJKDK2KFKGKKKKKJKKKKK1KKK;KK:KFKKAK'KKKKBKKKBKK?KDKKKJEKKKGKKKIKKKKKKKKGKKJBKKIK4KKKKIK=KKHKKKK;JHKKIKJKKJJEKKKKI3KKKKKGKKK>KEKKKKKK1CI(KKH9KKJKKJ?KKFKKK9KK>GFKKJI7KKJJGKKKF;KKK%JKKK(KKKIKKKJGKKIKKJKKJJJK @rCer/1643/25_1590_CCS ATGGGGAGGATCGCAGTGCGCGTGGCGTGGCGGCTGGTGTGGGGTTGAGTCAGTTGTGAGACCCGGAGCTGGTGACCCAGCGGTGGCCACCGAACCGGCGACACAGCGACAGGCGTCAGGGCTCGGGACTGCGAGCCTGGCCTCGTCTTAGAGCTCTGCCGAGCCGCCGTCGACCCCGCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCGCTCTGCGCTGTCTCTCCGATGGCGTCCGCTCAGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGACCCGCCACAGACCTCAAATTCAAAGGCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAATCCGTCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCACAGTGGAATCATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGTGTATTTGAAATGCCTAATGAAAATGACAAATTGAATGACATGGAACCTAGCAAAACCGTTCCACTGAATGCATCTAAACAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACTGAAACAAGGAAACTAATGGAAGAGAGTAAAAGACTTCAGGGAGAAATGATGAAGCTGTCAGAAGAAAATCGACACCTGAGAGATGAAGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTATTTCTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCACTGGTAGTACGGCCCGCGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCTTTAATGATCTCTCATGGTTAGAAACCCAATAAAACAAACTGTTCGGCTCCTGGACAAATTGTATAGTACCAGATCATCACTAGCAGATGTCAGTTGCACATTCAGTCCTTTATGAAATTCATAAATAAAGAATGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGAAATGGTGCCTCTTACAGTGTAAATTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCTTGTGAGGCAGTGTTGACTGAGTTTTCATCCTTACAATCCTGTCCATGTATTTAACATAAAAAAAATAAAACTGTTAACAGATTCTTGC + <>,GGDB7A77=D07?602@4@:1/&=@2DFAFAC.;<4<'9??>CFF9=97:4E@@=E@=DC?>7*D@@+9DFEAE=DE2B.@2:A=:?C:A@@:B,#@DB@-:/EB;7@;:89/>$<>F9?C@B=196(7560AE9FEC4D><>G9B;FB2B:>?BD:AC9D51E@DC@7GC97$?D/@C+>ABE9<4=*@C=;@FF8AGFC*>*E9*:@A.%@;?F@;C@E=EBE&DDD5:93:,CDD&75=E@;:>;C64CAB42)B7AGBIFJ?E9/ADB(;>7*@D@B=C>=;9BB@E?4B@@C;=)HAIFH@HB=>C;93GC*B@?,D;>ABB:.C;.9;4;3-A=?;08<9?;6>@=8&B<>;;@*BGG2FFFH'DEDH?A'DGACDFF;ED8BEFE=;=E9A,G?I4GFCIB,8@G0FH@G6G=6BDABAA=5=?B7HHGCGFE@'FH>JF?CH4E(H@@%;78;,%2<9'<=?EF7J9B18.2?D>B0AB?*?AJ(EB@A6?88H-F5-A;CH=ECICE:'?E=(=;>--?<487/)0E?=CE?A>E=IE3IHHDII@A?3AC=EA>F@E;/1**?DDGEE?=EFB7FF&E@E6CFBCHF=/>DI1II.@<%<>4C(=??;A;DC8HFAEGG5G:AIGIGA@ABCDF@?3>9E?7D@=GCD7<.?>;JF7?94><5JGBCI9>G?DEEA?D@D>?BCBE769.??;)CA@ADBBB'?>*1?E2@7@3EHHHFC5FCE2FC?;>=?;?:4:;B=E=597<43+45>.>@C@+=6@=1B;0=AEEF;3>@>78>::8?69/9:==63<93B>@)88@<8@?E::?060BA:A;?32&<9$;:>@<%<9960?@>9=+:9)9;A>EA?D<;,?B6FC<>EA7=:6G771C:71>B8>AAC6=:>+@AB>CA,@E?C:BC5B>BF:G?8GF@D??7<.>@?2;C;2;G=8A;C9?E444%50+>8$+#&969>;7;)47=2:(@:11+=@FC;B<:>>D@CD?8;=7<>7C1C9EF@BDC51F>C:D*D?).=@@B@@&>@B>9:BA8*44;?;6?<>3#:559;@.>*;A@5=5);5=;+=:<3=B9EC.C?><$:=59<:>=(4<@:?C:A1>4:C1/E@9BAE @rCer/1644/0_1059_CCS TCGGTCGGCTGAGCTTTGCCAAGTGGCGCTGTGTGCTGAAACATAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAATGCAAACGTGCTGGCCCGCTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAACGTTGTCAGTATGTTACAGAGAGGTCTTGCTGCTGTGTACAGGCCCTGAGTGACATCATGTATACCTGGAGGGGACCCTGCTCAGCCCAACATGGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCCAGAGGAGATTGCCATGGCAACTGTCACTGCCCTGCGTCGCACTGTGCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCGAAGAGGAGGCATCACTCAACCTCAATGCCATCAACCGCTGCCCCTTCCCCGGCCCTGGGCGCTTACCTTCTCCTATGGGCGTGCCCTGCAGCCTCTGCACTCAATGCCTGGGCGAGGGCAACGGGACAATGCGGGCTGCCACTGAGGAGTTCTCAAGCGGGCTGAGGTAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAGATGGTGGAGGCAGGCACAGTCCTCTACATTGCCAACCATGCCTCTGAGTATCTACTCCTCCACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCTCATGACTGAGGGCAGAAGAAATTGCTAGGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATTGGGGTAGCTTCTCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGTAG + S"##%#"#&$#'#(%&%)))&',)&+*(%$(())*(((%,)"###(''*+(,+&%'++*,+%)+),)-+,,'%+&(',&()'%#""')++-*$()-'(&("&''+&)&'%%)(&'+.,*'#(','$)+')(&*+*,)%&*+,*-$(#,*+')&'%&*(&$'))*(/012-0,+0/%011,20.&-1/142413&'*4/+0*(.$,+,*(($.'102,234.-%&''1542.3//%$,0-(,0/-11'02,2-+4521%00233/.*2'43)/)22%/+.2&(,--&&,+4)+0,533444&,32)./*-*-(241*35363.(&52+52416)*0&,*552///+0+/150,164.4+35/%100+*1023(/0()5)2.1-,40412523)1)30*1/+,5500/).(/&+')2.*(/+0.105(,/2(01.-0-',-3,4-&#)&/0324$.-*).-4/416512/)2(,2243..3/*-,00.-/1*,,/%*''#()+/.-'--/*/11++($,+(+&+*+-%)*+1*)++,()$"#&(),'.,)*)++,$,$,($,%,.,/2/*/0-*-(#&)%+.-*.'/)/()1/$..+.0-++)-&./00&00(*)&#(-..2//.($()2%%.%-031%5)(*'-'+/-(%(,-043)+2,&0(&*,-)%+-&$#$$#)('+--.-02.2*0..1+1.-/,.42$)).((12-.*145.-54%.+/34;,7:2)6)768/45.5.20(414/3.+.272+2390462(+03.-1/4,0-0401669/223/-,7/6,372%,.1-1594234-/040,25537+9:324.,(*44/&.-),124519810%43'1,*1234'3/74/,2$+)'-),341650%3/2&1-34)/616,420//53*.&./121,*,(.3618.+//%12.,)0,663$.11583'1-3(53176384:38.41::97776959718584:6(430+'-/-27-24.75*578554297680658*3994/8815499.9321-0-5131106))&(/250244*442+,,+0 @rCer/1651/25_1628_CCS ATGGGGCAGTTGGCAAGATGGCGCCGGTGGGGTGGAGAAGAAGCTGCTGCTGGGTCCCAACGGGCCCGCGGTGGCGGCCGCCGGCGACCTGACCAGTGAGGAGGAGGAAGGCCAGAGCCTATGGTCCTCCATTCTGAGCGAAGTGTCCACCCGTGCCAGGTCGAAGCTGCCGTCCGGCAAGAACATCCTGGTCTTCGGTGAAGATGGTTCTGGTAAAACAACCCTCATGACTAAACTACAAGGAGCTGAGCATGGCAAAAAGGAAGAGGCCTAGAATATCTCTACCTCAGCGTCCATGATGAGGACCGAGATGATCACACGCGCTGCAATGTGTGGATTCTGGATGGAGACTTGTACCACAAAGGCCTGCTGAAATTTGCAGTTCTGCTGAATCCTTGCCAGAGACCCTCGTCATTTTTGTTGCAGACATGTCTAGACCTTGGACTGTGATGGAATCTCTGCAGAAATGGGCTAGTGTTTTACGTGAGCACATTGATAAAATGAAAATTCCACCAGAAAAATGAGGGAGCTGGAACGGAAGTTTGTGAAAGATTTTCAAGACTATATGGAACCTGAAGAAGGTTGTCAAGGTTCACCACAGAGGAGAGGACCTCTGACCTCAGGCTCCGATGAAGAAAATGTTGCCCTGCCTCTGGGTGACAATGTGCTGACTCATAACCTGGGATCCCGGTGTTGGTGGTATGCACAAAGTGTGATGCGGTGAGTGTCTTGGAAAAGGAGCACGATTACAGGGATGAGCATTTGGACTTTATCCAGTCACACCTGCGGAGGTTCTGCCTTCAGTATGGAGCTGCCTTGATTTACACATCAGTGAAAGAAGAGAAAAACCTCGACTTGTTGTATAAGTATATTGTTCATAAAACATACGGTTTCCACTTCACCACACCTGCCTTAGTTGTGGAAAAGGATGCCGTTTTTATACCTGCAGGCTGGGACAATGAAAAGAAAATAGCTATTTTACATGAAAATTTTACAACCGTGAAGCCAGAAGATGCATATGAAGACTTTATTGTGAAACCTCCCGTGAGAAAGCTGGTCCACGACAAAGAGTTGGCAGCAGAAGATGAGCAGGTGTTCCTAATGAAGCAACAGTCACTCCTTGCCAAGCAGCCAGCCACGCCCACGAGAGCTTCTGAATCTCCTGCAAGAGGACCCTCTGGCTCTCCAAGGACTCAGGGTCGGGAGGGCCAGCCAGTGTGCCTAGCTCCTCCCCAGGCACGTCAGTAAAAAAGCCGGACCCAAACATCAAAAATAATGCTGCAAGTGAAGGGTGTTGGCCAGCTTCTTCAACAGTCTGTTAAGTAAAAAGACAGGCTCTCCTGGAAGTCCTGGTGCTGGTGGGGTGCAGAGCACAGCCAAGAAGTCAGGACAAAAGACTGTGTTGTCAAATGTTCAGGAAGAACTGGATAGAATGACTCGAAAGCCAGACTCTATGGTAACAAACTCTTCAACAGAAAATGAAGCCTGAACCTCCTTAAAAAGTGCATATGTCAAATGACCAAATAACTATGTATATTGATCTGCTAAGACCAGGATTTTTCTGATATGGCACATGCTATCAGTTTTTTGGGGCAGGGGAGAT + KK-KKKKKKHKBKKHKHDCKKKK8KBGK4KKKE2;JKHKI?KJKKKKKKKJBIKK*KKKKK3KI*KIKKKKKKKKHKEKKJKDKKKKKKKKKKKKGKKHKKJKDKKKKK:KJICFJKKFKKIKJHK>KK?KHHCKKJKKKGKICK8KEKJJGI=9KKKJFK/JKKJKKDJIKBKKJKHKJKCKKIKHKKKKKHIKK%IKKKIKGKKH;IHKKKKKJKKKKJKKKKKJKKKKKKIKEKFFDKKKKIIKKJKGJJJKKKKCIJJK>KKKJKKKKKKKKHEKKJEKKKKKKEGKIKKKJKKKKKKKKKGKKKKDK;KKHKKIJJH'KIKIKKJEKJDKKKKIKIKJKKKKKIKKJKJ2KKKKKKKKHKJKKKKJJKKKK9@KIKHKKKKKKKKKFKHKIKJEGKJKKHKKKAKKKKKJKK?KKKJKKKKJK@FKIKHJJI0KKKKIK=KK-KKKJFKKJEJKKKKG1KKKKKKKKDKK=KK1KKHKKK;JKJFKD@KKKJDK;JKJKJG$IKEKGK2KKKKKG9KKJKKIKKKKKJKKJKJKKJ9JJKKKKKK.KJKKKDKKKKHKJHKKGJKKKKKHKJ*KKIJJKEKKKKKKJKKKJKJCKJJKKKKJKGKKKKKKEKKKKKKKKJKKJKIKKI2JKKKAKKKIKKIKJGKIKKKKKKIKKF6KFHJKKK;H?EKHCKKGKKKJEIJKGKIKK/KKKKKDFK@KHKKKKKHK:KKFKIKKKEKIKKGKIJ.KFAKKKKKGKIKKEFJJKKKKIHKKKKKKKCKKKKKKGKIKKKCKKKJ*KJJKJKKK,KKKFKKHJJKKJKHKKIKDKKBKKKKIIFKKKKKKEIKKKKKJIKKKIKGKIKKGKKKJKBKJKIKKKKJ,JKKIKJKKKKKFJK1KDKKJK?KHKFIKKHKKKKKGKKKIIKJKKKJKKKKAKC3KKKCKKEKKKKKKJKKG>IKKICIKIKKKIKKKJKKIKKKJKKIKJKKKCKKGKGKKKHJIJKJIIKCKI=IIFKFKKKKKHHKFKKKKKJKKHHKKJIKIKFKKKKJ=IKKKHKKKKDKKKKKIKKKJKCKKIJGKKKIKJ=KKGIJJHEIBJKKIKJKK?KEKKKKKKKKKKKKKKKJK?JBJKKJIJKJJKHKKBJKFKIIKKFKKKAJ5KKKKKKKKJKKKKKKHIKJKKGJGIKKBIKHKJKKKKKKKKJKKKJKIKJKHKKJIKGKKGKKJKKKJKJKIKJJKKJKKKFKKKKKKKHEKKKKKJK?KKJCKKKKKKKJEKGKKKKKKKKDKKKKKKJKKKKJKKKJKKFKJ>KBKKKKKKKKAKKKIKKKKJKKHJKK?KKKKHHKKKKKKKDJKKKKJKKKKJJAK7KKJKKFKKKJKJKJKKKKKKKKJHJKIKKKKIKKKKKKKKKKKIKKKKJKKIKKKKKKKKJKHKJJKKKKJKKKKKKJIJJKJ>KKKKKIKKHKKJKKK@KKKKKKKKKKKIKKBKKKKJJAKJKKKK?B9KEHKBJKKJKKKJKK1KKKJKKKKKFKEJKKKKKJJ2KKJJJK=KGKK7KKKJKJKKKKGKJKIJBIGGIDGJJJKDJJKEIHIJKIKKKKKJKHKKKKJKKKKDKKIK9KKKKKJJJKKF3KK:KJKKKKKKKEKHKKHKKIKKKKKKIKKKKKKKKKJKKKKKKKKBKKKKKKKKKKKKJKKKKJIKEKJKKKBKKKKKKJKJKKKKGKKKKJJGIJKKKKKCKKJGGJKKEKKIKKJKGJKKKJKKKKKJKKKIKKKJKHKIJKKKKGKKKJK@KKKEJKGKKKKGIKKKKKKKKKJKKKKKKKGKKAIKKKGKJKIKKKKKKKKKFKKKHIKJHKKJKKKKJHKFKKKKKKKIKKKKKKKJJKCKKKGKKHKKKJKKKK7KKKJKG@KKKKFJKKKKKKKK%JGKKKGKJDKKKKDKGKKKKKDKKJKKKKIGKKKKKKKKHKKKKKKKKJKKKK@KKJKKJKKKKKKKKBBIKKKKKAKKKKKKKKKKCKKKKIKKKK=KKIKKJKDKKKKHJKKKKKJK0KHBKJKHKKKKKKKKGKKKKJKKKKK?KKKIKKHHIKKKKKHKKKKGKKCFJKHHHKJK?KKGKKKJKKKKKKKK=KKKJKKK:KKKKCKKKKKJJKJKHKKHKKKKKCKIDKKKKIKKKKKKKJKJKKKKKFKKKEKJKJJBCKKKHKJKK @rCer/1654/1325_50_CCS CGGGCCATCTCCTACACCTGGTGCAGAAGCCGTTCTCTCTGACGAAAAGTGTGCTCTTGGACCTGGCCTACGCCTATGGCAAACTTGGCTTCACCAGACCCAGGTGTCCAGCGCCTGGCTGCCGGACCTGCTGTCCCTCATTGCCCAGCCTGACTTCTGGTGAGGTGGCCCGCTGTGCCAAGTCCTTCGCCTTACTCAAGTGGCTCAACCTGCCACTGTATATGAGGCCTTTGCCCAGCACGTCCTGAACAGAGCGCAGGACTCACCGTGCCTCACCTATGCAGCGTACTTCTGGCTTTTGCGCGTCTGAACTTCCATCCAGACCAAGAGGATGAGTTTTTCAGCCTGGTACATTGAGAAGCTGGGGTCAGAGCTGCCAGGCCTGGAGCCAGCCCTGCAGGTAGACCTGGTGTGGGCCTTGTGTGTGCTGCAGCAGGCACGGGAAGCAGAGCTGCAAGCCGTCCTCCACCCTGAATTTCACATCCAATTTCTAGGGGGCAAGTCTCAGAAGGATCAGAACACCTTCCAGAAGCTGCTCCACATCACGCCACTGCCATGCTAGAGCACCCCGAGTACTCAGGTCCCCTTCTGCCAGCCTCGGCTGTGGCCCTAGGCCCTCAGCCCTTGACAGGAAGGTGACCCCCTGCAAAGGAGCTGCAGGAGACACTGAAGGGGCTGCTGGGGAGCGCCGACAGGGCAGCCTCGAGTGGCCACGCAGTACGGCTGGGTGCTGGAATGCTGAGGTGCTGCTGGACAGTGACGGCCAGTTTCTGCCGTAAGGGACTTTGTGGCACCTCATCTTGCCCAGCCAACTGGGAGCCAGCCACCACCTGCAGGGGCTAAGAGGCTAGCTTTCCTGCGGTGGGAGTTCCCCAACTTCAGCACCGAAGTAAGGACTTGTTGGTCGCTTTGTTCTGGCCCGCGAACATACTGGCTGCAGGCTTCCTGATAGTGGAGTCCCATTCTATGAGTGGCTGGAACTCAAGTCTGAATGGCAGAAAGGCGCCTACCTCAAGGACAAGATGCGCAAAGCAGTGCTGAGGAGCTGGCAAGTGACTTGTGCAGCAGCATGGGCCGCCTGCCTCTCTGCTGGAAGTCTAGCCGTGGGTGGGCAAGAAGGGTCACCCTTGAGGACAAACCTCCGTGCAGGACCTTGGCCAGAGTGGGGAGGGTGGCCAGCTGCTCTGAGGGACAGAGCATCCTCTTGTGTGTAATAAATCTTTTAATTTTGGTGTTAGACCCCTGGGGCCTCCCAGGCCTGTCACCCTCTGCACT + #$*&+(()*))*%%$&)$(*(,*/,-1(*0,,()))&#*,--)*-,*(,%*.-'-,,'00+%$',).-,)001(,+.+,).1()001+*-)+*0.00%*-),-&'.).%**)-+*02-)+02/%%*-(./',)$/1(%$$%%$0.)%),',.(&+-,(,,,,1(-*.,-**,*+$(+/'*%-,/*10,,.&'+,+/02.,..)++++'-,*/0+..+/'$&%*.&-&0%+/$,./,,&+.,,+-)*00%-,$*,'+,-1.+$.,'+,10+*#*,00-1-+(,,'-+)+-0*,1//0-./'*+,*-*0)-2.1-,-)')+)*,*.+)'*+),/.,++/.+.%...01/-*.0-&&%-..0-1*1)%)$,(0/13/,.1(/0040,2-012/.363+4/24012-0+./).,-3436/115.-/2+)24.,%),.211.230*1)0022.*0664642*.640)1..-.///0*/+$-3'3-1/,,&.-//',3.4436/441//,))145)/&1.10+23523./1620/,(+4'/-.2,1..//$,161/-*10*21640+/.13/-.0((&.5/00,16,/1/0'30,214/425040-*0423,(12&0.1,/+%'%*33.'2$/.0*2-3020..22+)*#%',35'1232+554*/,//242.*21*++-&,&314-(($14231,,5.//1*4,*,'./3.#15/1)1/)(5..*/3.1410))*5./)($02003-+)012'-)/*1(/3.36426.30520/(/)/0%1+5466/1/12,242).-0&*0/.0,+463*3--(-'+)13)..43/.0&04,261121422/)4.-*/+4&+113.0/&1*-/)-*103&,'5)-1/'0(140++-.)+#/+%./1/6251,/03.2%/03101.+/**/3(50&$.0$*.''+/55,1033//,+3+.*22(/30131#1203)15234,.13.13)/11+6.025625.51,2/4602,066/2(05611/42544*5.1/-)0/0263035+55.,0'.$35520/4261#(+-),541152+$2-4102,/+/%3(31*203,1203//0-411134.5/.2*25.('/22,3442-%(,))/)4+)-+22/)'1-%&.-,1.0011244065356061,.+..-/)$('&$10(3),/,51032*2.45-4-*/,+*+-4/34602,00442*564/22145*10/12'1+111,20566113433&5*##4,52.1'$1.00+1,.1314./2 @rCer/1655/1659_62_CCS ATGGGGCGTTCGCAGCCGCCGTCGTCCCGTGGAGGAGCGCGCAGCCCAGGGGAGGTCGGAGGACGCGCCCATAGAATGCCCAGGAGTGACGAGCTGTCCTGAGCCCCTCTGGTGTACTCACCTGCCTGTCCCATACGCCCCGCCCACCATGGAGTCCAGAGGGAAGTCGGCCAGCAGCCCTAAGCCTGACACCAAGGCGCCCCAGGCCACCACCGAGGCCAAGGTACCCCCGGCAGCCGATGGGAAGGCCCCCTCGACCAAGCCCTCGAAGAAGGAGGCCCCGGCCGAGAAGCAGCAGCCGCCAGCGGCCCCCACCACGGTACCTGCCAAGAAGACCCCGGCCAAGGCCGACCCTGCCCTTCTCAACAACCACAGTAACCTGAAGCCGGCCCCCACGGCCCCCGCGGTCCCCAGCAGTCCTGATGCAACCCAGAGGCCAAGGGTCCTGGGGATGGGGCGGAGGAGGACGAAGCTGCCGGTGGGGGGTCTGGGGGCCAAGGTCCCTGGTCCTGCGAGAACTTGAACCCCCTGCTGGTGGCTGGAGGTGTGGCCGTGGCAGCCATAGCCCTGATTCTCGGTGTGGCCTTCCTGGCCCGGAAAAATAATACCTGGGGGCCGGGCGGGGGCACGGAGTCACTTCCTGTACAGACCTGAGGAAGCCAGTGCATGCAGAGTTCACCCTTATCTACGTGTACACACGCACATTCATTACACACCTACATATGCCCCCAATACACACGCAAAGTGGAGAGGATGCCCGAGCCCACCCCTGCTGACCCAGGACTTCCCCAACCTCCAGGGCAGAAAGAGTCCAGGCTCCGGGTCCACAGCACAGGATGCGGGGAGAAGGCACAGCTGGGGAACCTCAAGAAAGGAACAACGGACCCATGTGTGGGCCCCCCACCCCCGGCAGCTGGGTGATCCCGGGCCCCAGGGCTGGTCTCTGAGTGGGGGTGCTGGGATGGGTTCTGCCTGGGCCCGGCCCTCGTGGGGACATTAAAGGGCACGGTTGCTCCACTTGCCCCAGTTCTGCTCTTTGTGTACCCCTGGGGGTCTGCCTGGGCCGATGCAGTGGGACAGACCTGGGGTGGGCAGTCACCTCAGCAGAGCCTCAGTGCCACCTCCCCACACCACCCAAGCCTAGCTGGGTGGGAAGACGGAGCCTGAAGCCTGCTTGTGGAGGGGGTGCTGCCCAAGGGTTGCCTTCCCCAGCTTGTGCTCCAGGGAGCTCCGATGCTGGTGGGGAGGCAGGATGTCGAGGGCCCCTCATAGTTGTGCCACCCTGCCCCGCTAGACTGCCCCTCCAGCTTGCACCTGGCACCATCTGAGTCTAACCAGCGTATAAATGCAATAACAGGTAGAGTAGAACTGCTTGGCGGCGACCGTCACACACTGTCCTCAGCCCACCGTACCTGGGGAGGCCCCTTGTGCAGCCCCTCCTTAGCACATCCAGTCCCAGCGTGGTCTTTGGCGTGCAGCAGCAGGCCAGCTCCGGAAGGTGGTGGTGGCACTGTGAGAACGCAGCCTGCCCACACTGGCCAGCGGCCACAGGAACCCTGGGCCTGAGTGGAGGCTGAGTCTGAAATAAACTCTGTTG 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@rCer/1656/3090_57_CCS ATGGGGAGAGCCAGGGTAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCTTCGGGGGAGATGATGGTGGGGGCCTGGCTCCTGGCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCCTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGACTTCTCCCTGGCCGGAGCACTCAATGCTGGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGCCAAGGAGCCCACCAAGCTGGCCGACGTCTACCAGGCTGAGCTGCGAGAGCTGCGACTGCGGCTCGATCAACTCACCGCCAACAGTGCCCGGCTGGAGGTCGAGAGGGACAATCTGGCACAGGACCTGGGCACCGTGAGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGGAAGCAGATGAAGCCACCCTGGCCCGTCTGGATCTGGAGAGGAAGATTGAGTCACTGGAGGAGGAGATCCGGTTCTTGAGGAAGATCCACGAGGAGGAGGTTCGGGAACTCCAGGAGCAGCTGGCCCGACAGCAGGTCCATGTGGAGCTGGACGTGGCCAAGCCAGACCTCACCGCAGCCCTGAAAGAGATCCGCACGCAGTATGAGGCAATGGCGTCCAGCAACATGCATGAAGCTGAGGAGTGGTACCGTTCCAAGTTTGCAGACCTGACAGACGCTGCTGCCCGCAACGCGGAGCTGCTCCGCCAGGCCAAGCACGAGGCCAACGCACTACCGGCGCCAGTTGCAGTCCTTGACCTGCGACCTGGAGTCTCTGCGAGGCACGAACGAGTCCCTGGAGAGGCAGATGCGCGAGCAGGAGGAGCGCCACGCGCGGGAGGCGGCCAGTTACCAAGAGGCGCTGGCGCGGCTGGAGGAAGAGGGGCAGAGCCTCAAGGACGAGATGGCCCGCCACTTGCAGGAGTACCAGGAGCTGCTCAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAACCGGATCACCATTCCTGTGCAGACCTTCTCCAACCTGCAGATCCGAGAAACCAGCCTGGACACCAAGTCTGTGTCAGAAGGCCACCTCAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGATGGAGAGGTCATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGAGGCAGGACCCACCTGGTGGCCTCTGCCCCATCTCATGAGGAGCCCGAGCAGAAGCAGGATAGTTGCTCCGCCTCTGCTGGTGCATTTCCCCACACCTGAGCTCCCCGCCACCCCAGCTGCTCCCCTCCCTCCTCTATCCTAGGCCAGCTTGCTGCCCTAGGCTCCGTCAGTATTAGGCCTGCCAGACGGCACCCACCCAGCACCCAGAAACTCCAACTAACAAGAAACTCACCCCCAAGGGGCAGTCTGGAGGGGCATAGCCAGCAGCTTGGGTTTAGAATGAGGAGGAAGGAGAGAAGGGGAGGAGGGTGGGGGGGACCTACTACATCGCCCTCCACATCCTGATACCTGTTGTTATGGAAAACTGTTGCCAGAGCTGGAGGTTCTCTCAGGGGTATCTGGGAACTGTGCCTTTGAGTTTCCTCAGGCTGCTGGAGGAAAACTGAGACTCAGACAGGAAGGGAAGGCCCCACAGACAAGGTATCTTTGGCCAGAGGCTTGTTTTGTTTTTTTGGTTTTTATGAGGCGAGGTCTCCTATGCTGCCCAGGCTGACCTTGAACTCCTGGGCTCAAGCAGTCTTCCCACCTCAGCCTCCTGTGTAGCTGGGATTACAGGCTCGAGCCACCATGCCCAGCTCAGAGGGTTGCTCTTCTAGACTGACCCTGATCAGTCTAAGATGGGTGGGGATGTCCTGCCACATGGGGCAGTCACCTGCCAGATCCCAGAGGGACCTCCTGAGTGATGACTCAAGTGTCTCAGTCCACCTGAGCTGCCATCCAGGGACCCTGTCTGTGGGCGTGCTGTGGGCAGGTGGGAGCTTGATTCTCAGCACTTGGGGGATCTGTCGTGTACGTGGAGAGGGATGGGGTGCTGGGAGGGATACAGGGGGGCTGCCTGGTCCCCAGTGGTGGGTACAGAGAGGTCAAGCCCAGGAGGACTGCCCCGTGCAGACTGGAAGGGATTGCTGGTAGAGATGGTGGAGGAGGCAATTGGGATGGCGCTAGGCATCCAAGTAGGGGTTGTGGGTGACCAGTTGCACTTGGCCTCTGGGTTGTGGGAATTAAGGAAAGTGACTTATCCTCTTGAAGATGCTGAAAAAGGAGAGAAAGGGGATGTATCCATGGGGGCAGGGCATGACTTTGTTCCAGTTCTAAAGGCCTCTTCCTTGCTGTGTCATCCCAGGCCATCCCAGCCTCTGAGCCCCTGGGACTGCTGCTTCTTGACCCCAGTAAGCCACTGCCACACGTCTGACCCTCTCCACCCCATAGTGAGCGGCTGCTTTTCCCTAAGCCAAGGGCCTCTTGCGGTCCCTTTCTTACTCACACACAAAATGTACCCAGTATTTTAGGTAGTGCCATATTTTACAATTTGTAAAACAAGCCGAGCAAAATGAAGACACTGGCTCATATTCCTGCAGCCTGGAGGCCGGGTGTCAGGGCTGACATGTCCACCCCAGTGCACCCACTCTGCTTTTTAACTGGGCAGACTGGTAAGCAGACTGGTGGGATCTGTGCCCAGAAATGGGACTGGGAGGGCCCACTTCAGGGTTCTCCTCTCCCCTCTAAGGCTGAAGAAGGGTCCTTTCCCCCTCCCCAAGACTTGGTGTCCTTTCCCTCCACTCCTTCCTGCCACCTGCTGCTGCTGCTGCTGCTAATCTTCAGGGCACTGCTGCTGCCTTTAGTCGCTGAGGAAAAATAAAGACACATGCTGCGCCC 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@rCer/1657/25_2165_CCS ATGGGGGGACTCAGGCGCGGCGCTCGTAGTGTGCGGGAAGCGGGGGAGAGCGGAGCCTGTGGACTGGCAGACCGTCGCTCGCTCGCTCGCTCGCTGGAGACTATGCGCAGGCGCGGTGCACTGCGCGCCGGCACTAGGGTGTTTTTTGCCGTTGGCTGTGGAGAAACAGCAGGCGGCGTGGACTGCAGTTGCTGAGCTGGTGTGGAATGTCTGTGGTCAGGATTACCCTCTCCAGATGTTGGTGCCTGGCTCTTGGACTTCCCAGCCTCCTAGAACTGTGAAAAAAAAAAATTAAAGAAAGTAACAGGAGGTGGCCAAGATGGTCAGCTAGAAGCAGCTAGTGTTTGTGGCTCTCACAGAAACGAATGGAAGGAGAAAGTAAATACAGCACCTTCAACTGAAACATGCAGGTACTTGCTTTGGGAATAATCAAGGAAACAACTCAACCACAGAGAACAGAGAAAATCAAGGCAGGAAAATGGCCCATCTGGGAGCAACACAGAGCCAAGGGAACCTCCCCTGCCCAGGAAGTGGTGAATGAGTGTGTCACCCCAGGAAGCCACACTTGTCTCATGGATCTTTGCAACCCTTGGGTTGGGAGATGCTGTCGTGAACCCGTTTCACCAGGGCCTTCAGTCTGACTGACACACAGAGCTACAGGGAGTCTGAGCAGAGCCCCCACAAGGGGATACATGGAGACTTGAGAGCGTTAGATACTAGATGGCTTTCTGGGCATCCCAGCAAAAGCAAATGCAACTCCAGCAAACTGGGAGGTGAGACACCCCAACCCATATATACTCCTGGGAAAAAGGCTGAATCCAGGGGGCTGAGCAGCAACAATCTACAGGCCCCACTTCCACGGCACCTCACGGGACAAGACCCACTGGCTTGGAATTCCAGCCAGCCACCGGTAGCCAAATTGGAGCTCCTGGGGGAGGGGGAAGGGCACCATCTTTGCTGTTTGGGCAACTTAACCATAGCAACCTTTGGGCTTTGGAAAGTCCAAGCCACCAGGGGCGGAAGGGATTCCCCAGCGTAGCACAGCTGCTCTACAAAAACACGGCCAGACTTCTTTTTAAGTGAGTCCCCGATCCTGTTTCTCCTTTCTGGGTGAGGCTCCCAGCTGGAGTCTCCAGCCACCCTGCCAGTGTTCTTGGGCCAACAGAGTTTTGAAACCTCCCTGGGACTAAGCTTCCAGAAGGAAGGGCGAGCTGCCATCTTTGCTGTTTGGGTGACTTAGCCATTCCAGCCTTCATGCCAACCAGAGGGTAGAAGTGGTACCTAAGTGCAGCACAGCTGCTCTATGAAAATGTGGCCAGACGGCTTCTTTAAGTAGGTCTCTGATTCTGTTCTTCCTCATTGGGCAGGACCACCCAACTGGAGCCTCCAGCCACCCCTGCTGGCATTCTCTGGCCATTAGCACCTGCAGGGAGACAGGAACCCCTGTATCCACCAGCACTCTGCTGCAGCTGCCACACCATAGCACTCGCCAGCACAGTGGACCCTAAACCATGAGGAGCCACAGGACAATGGCAGGGCTTGATGCAAGTCCCCCAGAGTTAGAGAACGCAGTCCAGGAGTTGGAATCTGAGCTTTGGCCCCCTAAAATCTCTCAAAAAAATGAAGCCAGTTGACAGAATTCATTTTATACCACAATCAAACCCTCAAGGTCATCAAATAGGATAAAACAAACAAAAAACCCAAAGGTCAGCAGCCTCAAAGATTGAAGGTAGAAGCCCACAAAGATGAGAAAGAATCAGCACAAGAATGACAAAAACTCAAAAAGCCAGAGTGCCTTCTTTCCCCAAAGGACTGCATCACCTCCAGCAAAGGTTCAGAACTGGGCTGAGGCTGAGATGGCTGAAATGACAGAAGTAGAATTCAGAGTATGGATAGGTACAAAGTTCATTGAACTACAGGTGTATGTTGTAACCCAATACAAGGAAGCTAAAAATCATAAAACATAGCAGGAGCTGACAGACAAAATAGCCAATATAAAGAAGAACATGACTTAGCTGATAGAGCTGAAAAATACATTACAAGAATTTCATAATGCAGTCACAAATATTAATAGTAGAAGAAACCAAGCAGAGGAAAGAATCTCAGAGCTTGGAGACTAGCTTTCTGACATAAGGCAGAC 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@rCer/1658/25_1941_CCS ATGGGGGCCGCGGCCTGGGCTGGGATGTGAGGAGCTGCGGGTTTCGGGGCTCCGGGCTCCGGGCTCCGGGTGGCGGCGGCTGTGAGCGGCGGCGGCTGTGAGCGGCGGCATTGCGTCGCCTTGGAGCATGAGCGCTGCGCCGCCGCGGGCTCGTCCTCCTCCGGCTCGGCTGCCGCGGCGCTGGACGCCGACTGCCGCCTGAAGCAGAACCTGCGCCTGACGGGCACGGGGGCGGCCGAGCCGCGCTGCGCAGCCGACGGCGGAATGAAACGGGCGCTGGGCAGGCGAAAGGGCCTATGGTTGCGCCTGAGGAAGATACTCTTCTGTGTTTTTGGGGTTGTACATTGCCATTCCATTTCTCATCAAACTATGTCCTGGAATACAGGCCAAACTGATTTTCTGAATTTCGTAAGGGTTCCTATTTCATTGATTTGAAAAAACCACAGATCAAGGTTTGAATCACACATGTAACTACTACCTGCAGCCAGAGGAAGACGTGACCATTGGAGTCTGGCATACCGTCCCCGCAGTCTGGTGGAAGAACGCCCAAGGCAAAGACCAGATGTGGTATGAGGATGCCTTGGCTTCCAGCCACGCTATCATTCTGTACCTGCATGGGAACGCAGGTACCAGAGGAGGTGACCACCGCGTGGAGCTTTACAAGTGCTGAGTTCCCTTGGTTACCATGTGGTCACCTTTGACTACAGAGGTTGGGGTGACTCGGTGGGAACGCCATCTGAGCGGGCATGACCTATGACGCACTCCACGTTTTTGACTGGATCAAAGCAAGAAGTGGTGACAACCCTGTGTACATCTGGGGCCACTCTCTGGGCACTGGTGTGGCAACAAATCTGGTGCGGCGTCTCTGTGAGCGAGAGACGCCTCCAGATGCCCTTATATTGGAATCTCCGTTCACTAATATCCGTGAAGAAGCTAAGAGCCATCCATTTTCAGTGATATATCGATACTTCCCTGGGTTTGACTGGTTCTTCCTTGATCCCTATTACAAGCAGTGGAATTAAATTTGCAAATGACGAAAATGTGAAGCACATCTCCTGTCCCCTACTCATCCTGCACGCTGAGGACGACCCGGTGGTGCCCTTCCAGCTTGGCAGAAAGCTCTATAGCATCGCCGCACCAGCTCGAAGCTTCCGAGACTTCAAAGTTCAGTTTGTGCCCTTTCATTCAGACCTTGGCTACAGGCACAAATACATTTACAAGAGCCCTGAGCTGCACGGATACTGAGGGAATCCTGGGAAGTCGGAGCCTGAGCACCAGCACTGAGCCTGGCTGGGGGAAGGAAGCATGAAGACCTCTGCCCTCCTCCCATTTTCCTCCAGTCAGCAGCCCAGCATCCTGGAGCCCCGGGGGGCCAGCACCTGCAATGCTCAGGGAGCCCAACTTGCACCAGGAGAGGACTCAGATGCCAGGTGGGGAGGACCCTGCAGGCCTGCAGTGCCCAGAGGCCTGAGGCGTGGCTGGTGTTAGAAAGCGTGGGTGGCAGGCACGTGGCTCTCCTTGCCGCTACGCAAACCTGAGATCTTGTTGGGAGATTTATGACAGCAGGCAGCCATCACTGCCTGGTTGATGCTGCACTGAGCTGGGCAGGGGGAGGCCGGGCAGGGACTCTTAGGGCTCAGGACCATGCTGAGCTTTCCGACACCACCCACAAAGAACGTGGGGTCCAGGTTCTTTCTGCCCTTCCCAGCACACGCAGAATGACTCCAGTGGTTCCATCGTCCCCTCTTGCCCTGTGTACCTGCTTGCCTTCGTCGCTGCCCTGCCTCCTCTGGGCTGGCCCACTCACCACAGTGGAGGTGCCCAGGATCTGCACTTCCTCCCCTTTCACCCACCTGTACGCCTAAACCTGGCCTTAGACTGAGCTTTTTATTTTAAGAATAAAATTGTGGTGGTGG 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@rCer/1659/44_2116_CCS GGGGTAACGGAGCTGCAGACACCGTGAGGAACGAAGGCGAAGTTCTCCACTTGAAGAGTTCCAGACCTGCGTAAATGCTGTAACAGAGGATGGAAAATGATTTTGATATAGCCTCTCTCTTGTGTTATCACGATAATAAGCACTACATCCTGGCCCAATGGTATCGGGTAGGAGACTCTCTCCAATTGAGGCTGACTGGCCTTGGATTATGGAGCGACATTGTTTACTGTGAAGGAGCTGATCGAACCTCAAGATAGATTCAGTAGCAAGAGAGTTGTCAATGAGGTCTCAGCACATGGGAACTTTGATCGCCCATGAATGATCGAGTTGTCTTCCGCACACTGCGAAAAGGAGCAAGCAGAACAGGGTGGCTACTTACCAGATGGGAACTTCAGAACGCAGGCGAGCCCATTCGCTGTGGCCCAGGACTGAAGAAAATCGATGTGGCTATGCGCATGACGTCCAAACATGGGCTGTCCAATAAGAATAATCCCACAAGGGAGGAATGGAGCTCTGCTCTGCTGTCAGACCCTGACAAAATTGAGAAGATCCTCAGCAAACGTCTTGTTAAAGCGGATACGCACACCTGTACCATGCAAAGATGTCGCATACCCTGCACCGGATCGCTAGAAATACTCCTGAGGACCTTGTGAAGCGGATAGAGTAGGACTGACATGCGTGCCAATTGCAGTTCAGGGAGGAAGAGCGGGAGGAGCGACCTCAGCATCCTTGTCGAGCTGTGAAGATCCAATCAAAAACGCATTGAGCTAGATACCATCTCACATTCATGTCAACTATAGCCAAACGGAGAGATCTCATGACCACGACGTCCAACGGTATTCGGCACATAGAGGGACCTTCTCGACAGAGCCACGGCAGCCCTTCTTGTGCTGGTGGCCCGAGCAAGCCATACGTGCGAACCTCATCTATATATCCTCAATGGAGGGTCTGCCGGCCCGTGGAGGACAGTCATAGCAAGAAAATACAATCAGATATGACGGTCGCAGTATGACCACAAAACTACACCAACACCAAGTAGCTCGCTTGTGCAGTGTACCGAGAACACGACTGGAGTCGCCCAGGGAGGTTGCTTCCATGCTGCCCATTCTTCCCGGGAAAATTGTGTGAGCGCGTATTGGCCTTGGTGCCTCTACTGAGGAGACCAAACACAGGAGCTGGATTCCACCAGCGGGCCAAGCTGTCAGCCAGGACTTCAGAGACAGGGGGCCAATGCTGAAGATACCTTCTGGTGTACATTAAGATGGCTGTCAAGCTTTGACGCCGGAGAGCATAACCCAGCCACAGATCACCAGACCCAAGATGTGTCCTACTTCACAGTGGTGCCTTGGAAGGAGGAAGTTGGCAACAGCCTGTGTATGAAATTCGGTTCAACGCCCTCAATTAGATCGCCTGTTCTCACTCTTATGTCACCACTTGTTGCCTGAATCACAAAGCTATCAAAATCCTACCTTGCTGGACAAGTCAACAGAAACTGCGGAGCCAGCGCTGCAGCCATCGTCTGTCTCGCGGAGCCAGGGCCTCCGCTGAGGGTCGGACTGGGTAGAAGGAGAGCCCTGCCTTGCCCAAGCCGACAAGAAGGGAGGCTCTGAATCAGGACCCTGGGGGCCCAGAGCTCCAGGAGCTAGCACAACCGTGGGGAGCTGTGGCAAGAGCCTCTTTCTTGTCGGCCTTCAGGAAGTGGTGTAAGAGAGCCCATCTTGGAAGGCTGGTGACTACCTTCCTGCCCCTAAGTCACGCCCCCTCCATGAGGCTCTGGTGCTAAGAGTGGCTGTGTGATGCCACAGGCATGAACCAGATGCTGGTCTTGCATCGGCAGGAGTTAGATGTCCTTGGCATAGGGGCCATGCACCTAGAGCGATCGGACCAGAGGGCCAACCGCATGGGTGGATACCTGGCCTCTTTGGTGGAGTCTGACAGGCGTCAGATTCTCCTTGAAACAGGAGCTTTTCAGGTGGTAGACCATCCCCAAACCTGCATTGGTACTCCGTGCATATAAAGACACCCCATAACCCTCAGACCCATGGACTGGCTGACTTCAGCCTTGGCATCCT 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@rCer/1661/18_1692_CCS ATTGGGACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACTCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGGATAAAGACTCTCATAGAAAAGAACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAATGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGAGCTCAGTGAGTCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAAGCAAAGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGCATCTGAGTCCAGCTCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCCAGCACTCCCCGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAACTGTCTTGTGAGCTGAG 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%##&13*21.-62+42214521/,65+11323172.',3)54'433*+0423:614854.97514803//529482428--143798.6,44-1.,+20314,/&-*(0,278634(352-0,031-010,0,8096*.)1(33,,.268548.336130.20.597*6157//4069/2,03502234534143709-**002&&((.-763:.1$32057-615+44417436+%+,055%/2'1''.+.773,2.368-23439797$25)357815444774/784410/..12+/-&,/01-1/07693,70.2/98316)4747467903433*5.72156,43859)2.3/85462'41&129.93:4/1.7885,6368:17436567,$,/'*(/2-8)20445+:70:9/467)&93-872,7:31*56++0+54659)/9)3*1;;%&0)0*12)47./3<+1'27496634.;<715680=/12<>795279;534=663==5-86>3;36>>977%151046/.0+:6%-4/35==9375927;98593790+14?3;:95,33.35<3+916,317-1-8/790844.7-8=4;08506510996=98-8.,409:9468//>49:834+42:60::847<.49:9983434;:?<282<'4)(8648,77;<:=7722<64/614/839:803,,569<(65:*8>=2,=17,3<2854>;6:.052'5)*7%14<7:66=628578?>824;*/3.17*:5(88086,842.-988,<95682><7667<8=681110<7=46/;95?+9+3500+40&/25.5453651767872759.8*;97;;6676.;<>8>:6.314:/<16(59=>424894:;17(41;-,8<>:7779'80:37578;=>:6<';66=74/3183:)6-+.14*:-(346+:;1)0,<(785.5.94<9581)1+6.78262669<;>;>29:;9=33;:898:0;<<<9;92:68711999:(44<=(9-8<:9099504-,;;;6:=<2;7)626:;>/26*444$5,(576;0,3436668:?5<543<75629975:6=;3.;=9;:=;<526099758+.+5839;8?7?9:&;3.6<31B11<6=>?63<96:<55959<:;27::0)2<=B;83;C;4=1?:8@33/>98CC9>AA@A??398:?B4B86=?8;96ABA@75.576987EB/9<;=B7C59;=51=9>?D4?FE>;@8B?C57@C@9@:@A>;<;=2:?2:C@A>96666@@D;81D6-A;?C=CD@BE:>8=@@0>=<-CEF@;09CC;6E7=A=5:/>(9:1558B8C2#4/+'*:6@<25(86@<2<:7>BB8>@6=A;$@9=988<89;=58;=5?D?B5=A.>59059>D7<87B2B?;;2?6C:9=38:77$2796CBDEC2=@:B@8?@D??;:;;74:647;@B;E698@?>?>09<6/?8.;.2>;:B*=D=@9)5AC8475<::?=:6B3?=2A>&C@/7;20);;:;9<@:<86 @rCer/1662/25_1734_CCS ATGGGGATCTGCCGCTCCCTTTGCCGCCGCCTTAGCCCGGGACCCGAACCCAGCCTCTCCCCTATCCGAACACCGGCCCCGGCTCCTCCGAGGCAACGGTCCCCAGCCCCGTCTCGCCGCCGCCATGGCGGACCCTAAATACGCCGACCTTCCCGGCATTGCCAGGAATGAGCCAGATGTTTATGAAACCAGCGACCTGCCTGAGGATGATCAAGCGGAGTTTGATGCGGAGCTGGAGGAGCTGACAAGCACAAGTGTGGAACACATCATTGTCAATCCTAATGCTGCCTATGACAAGTTCAAGGACAAGAGAGTGGGGCACAAAGGGACTTGATTTCTCAGATCGTATTGGAAAAACCAAGAGGACAGGATATTGAATCTGGAGAGAATATGAGATGCTTGGAGAGGGTCTGGGAGTGAAGGAGACACCCCAGCAAAAGTACCAGCGCCTACTGCATGAGGTCCAAGAGCTGACAACTGAAGTTGAAAAAATCAAGACGACAGTGAAGGAGTCAGCCACAGAGGAGAAGCTGACCCCTGTGGTGCTGGCTAAACAGCTGGCAGCCCTGAAGCAGCAGCTGGTTGCTTCCCACCTGGAGAAGCTGCTGGGACCAGATGCTGCAATCAACCTTACCGACCCTGATGGCGCCCTGGGCTAAGCGCCTACTGCTGCAGCTGGAAGCAACGAAGAACAGCAAAGGTGGCTCAGGGGGAAAAACCACTGGAGATCCCCCAGATAGCAGCCTTGTCACTTATGAACTACACTCTCGGCCTGAGCAGGACAAGTTCTCTCAAGCTGCCAAAGTCGCAGAACTTGAAAAGCGCCTGACAGAGCTGGAGGCAGCTGTACGTTTGTGATCAGGATGCTCAGAATCCCCTTTCTGCAGGTCTACAGGGAGCCTGTCTCATGGAGACTGTAGAGCTGTTGCAAGCAAAGGTGAGCGCCCTGGACCTTGCAGTTTTGGATCAAGTAGAGGCTCGGCTACAGAGTGTCCTGGGAAAGGTGAACGAGGATTGCCAAGCATAAAGCCTCTGTGGAAGATGCAGATACACAAAGCAAGGTGCACCAGCTATATGAAACTATACAGCGCTGGAGCCCCATTGCCTCTACCCTCCCTGAGCTGGTGCAGAGACTTGTCACCATCAAGCAGCTGCACGAGCAAGCCATGCAGTTTGGTCAGCTCCTGACACATTTGGATACCACCCAGCAGATGATTGCTAATTCCCTGAAGGACAATACCACCCTCTTGACCCAGGTGCAGACAACCATGCGTGAAAACCTGGCCACAGTTTGAGGGGAACTTTGCCAGCATTGATGAACGGATGAAGAAGCTGGGAAAGTGAGCACATTTGGGAGCTGGAGAACAGGGGTAATCCCTACCCTGTGAACTGTTAACAGCTTACATAGGGTTTCCCCTTTACTGTAACTCTAGCATCCCCATCCCATTTGACACTGGGGGCAAGGGTTCTTCTTGCATGTGGGGTTTACACCCCTCCCCTGATGAACTAGAGTGGTAGCTAGGGTTTATTAGAAGGTGGTCTCCCCTCAGGCCTGGGGGATAAGGACGTGGGCCCAGTCACATGCCAGCTCATGTCCAATATTGCTTTGCCTGGTGTGGGGAAGGATTGGGTCTTGTCCTCCAACACAGCTTCTGTGGCTGACTCTAATACTGTACAACTCTTTCTGACCATTAAATGCTGTTGTACTC + 3/4?:?;1.86,072)*1,.77;;?9*8<94;,9:/;93?982707$6+6:A?;?:=;6CAA75;8914A<<6/*6/5;<;249:9?1<8**2;-3203($2;<7*(1838/0(/6<9=/<>,57=/?=7@>7?=2(=;?C@45;4@:<9=4:;?@75:<=1:954086667059/177-332+0&.7$/42.7628<97>>;3569;9:;>2A782/150<4-6/>69<6?@DAC547??@<:376>/87@9=D@;;7E6F;;;6;@/<@@=754.)8<7:6=;C8:@=9>=?>:<96:9C<9B96'003%+:9-577$4:6??@>0=-1(%,4.;==;?@3<;9*.59598-;92;04>D;+>,2<>8D;(896?8A>1?3264;8;<=5=;AFB8>4589164409@;7:)4>?5-8&;/;9DD@?@@7=:54=;2336@=<93?<:49/<@<=?81890)=:>15;3<:9;;@?E,A;5518FE=:659>12>97?B81;655;219AA2<@=>:>5A@D,41=?;;:?<@=0@9?%6B@4<)0595%28&64.*.+2+/)21;7:;2+2;88*;?=7.@;BD05'+97'&078539>174/27-46/2+679>384;=55-1.31:7318413<:4>:;=?>;B07?6;7;85=@:7@<>872@D67:CCBGB7CA<<<<<@@:BB378635.9>0:<=015B9:A8$>87482=08781/0<@2>>BE@8/>>52D@;153D4;;9C>?>C::14B=08=<89?DBAB3:?78>5C@7885779048C=3>7=;=26<49:7-3100=:>;88.5$>6<=%-05<>69':5@788?7==>7>/7>=CB<7<51556&3.<<50;;=?;C??2A<09<505)4887>159876708:.6>>=9A==0=/(29=:/>6<9;<9<9<).8946=A>;68335=B87?.095@6?8*50<;@=6=B=2=7=3?7;739*7949=@8>9,-37:=<;87&=:75==<0<2*6847?>785=@5:@=@99:?/850>790<:896789?7)22:158<=7=>29;0=89<4=6B5A<088?23+97;397-=36.-46&5707017=6@;2<94474:7,,()(76/796>7,;,02'8:=8,77&1)/*0566=>8183'985,00-,/474:.)+13075<94:91$3299:669:98/9.<667534,897.)14454+7989?877522'90:7:9:>/:5;?;001893.86:.1262*+041.1105*&31/35,2784266,;993;>7<81>=<697)7;55-.6;7;2$12./0//6186765-852;<977>=/1;8'7:6-277;:9295=163=65(26,6589;7:;+0696<8=;78;??;96;205:3,8/73::8772;933'34235,%%)$&..7-4.3.2*-,*-06848/,./0,712026563.45:93++ @rCer/1663/25_1625_CCS ATGGGGCCTGAAGGGGGCTGGATGGGCAAGTCGGACGCGATGGCTCGAGCTCGGGCGGTGGCGGCTGTGGCCGGAGGCGGCGGTGCCTCCTCCTCCTCGCCCCGGCGCCGGCGGTGATCGGAGCGAGCTGCCGCGGCCCCCGATGAGACTGCTGGTGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCAGAGGATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCTGTACGTGAACATGACAAGCGGCCCGGGCGGGCCGGCGACGGCCGCGGGCGGCAGGAAGGAGAACGACCAGTGGTATGTGTGCAACAGAGAGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAATTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAGAAAAAGAAATACAGAGTGCTTGGTATAAATGAATGGCAGAATACAGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTGGCCCTGGTCCTCCCCTTTCATCCCTATGTGGAAAACGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAGGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCCGGTTTTGTTATCGAAGCTTTCACCAGACTGCCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCTTCAGAGTCCACATCCTCTGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTATGTGAAGGGAGGACCCTTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAAACCCAACTCTTTGTGAATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAACGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATTACAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTTGAAGACTGGCAATAAAGCTGTCCATCCAATTCCAAATACTGGTTTTAAGGTATAGCCGCTGATATTCTTTCATGTTTAGAATTCTTTCTGTTATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAG + E4'EBCCHG>>H;JHIHBC9F,E>KC>AJJJKAK3BD.6?FFJGHJ@CGCC=8EE7<8H<5DBAI.IH@7>DIHF7@8E>@9E>J5E496>>B;CDEGBDEJBDAEBIDG@1J@?G<@HFIHAI?5@A8G<@GGCA>;FFA5@EIHKKIGIKKKF$BDKC=@CI@>KKHK;8?DJFD4G?JE8KIA=DKCJ7JJFIJ6F-H@FDAKGAKJC5GC@CG@B:IKKKKCFIEJEEDF7@C=K@EGKJE>IKEC=BGJE@KEIE2BI?ABD<=9IJEF5FKKJEK>JIIDEDDIA?ADHK;JJKJJJJJKJKJ2GJBKFH?D5J=I>?IKGJIJJDK&IKJKJKKKKKJJJJKKKKKKCKKKKKKJJKKKKKKFJKHK@KKKFJ<4FHJKBKKKKKH?JGHKK5KJHJIJK@KGIAHIKJ,KKKKKFHC:JKKIIDKJK@JJIJJJKJKIFJE4FEKK;KKKHC0?HJ?EEJKKKIIJK7B6GJCFFGIKHJKKKKKKJHGKKKFJKJKGKEJ3KHKKKJJKJ;IKKKJBKKHKGEFKK>JGJKK:KKKKIJG8K0CKE:JK>CKI:KKIKKJBKCHGAGK:KKFKJE7KGBIKKCK>KKGJA36CCJKDK@KEIKKJJKKIGKHI@KIJKKGKKJJKJEK@JKKIDJK?HKKJKJKK=KKGKJKE?JCCKHJJGHJJBHJKIKKKKKJCKJGGH@HGKAFFKCK>KG=FK>/DCE5JKIJ>K=KGIEKK@DKIGCHJKJH?GGJJJBHKCF/DJ@=GD.HJDH?HKKKJKJ2KDJKJJ?>JKJHJFIHJGEA2F.HE;=KKKK=K-KHHB;DIK7KJKFCKJKKKI-IHEKKKCK=KKAKCKKKCCK&KKIKD-7DKKKJK3KHJKJFK;KJKKHKKCKDCHC@KIKKIKKKJJKKIKGJKKGKJKJKIKJJJKKKKKK@KIKKDFIKJKFKKEKK,GCED>IJ/HKKKKHFCH;JIDCFKKFKKJ?K/KKKKJJIKKKJFKIJGFCGEFKKHIJEHKKGKJKDJKJKKKGKBHGH&IKKKKKKEK@KKKDKKGEI>KKKKKKKGKFJCKKK>HDJ>KKKKKKKK5KKKKKFJ5B>AEHKFHKF5HKG6967?>7BA;;:;@>==A>B=;=3>::==A-@9796<:4>;67:7<>;A>?;8>B?A7:A6?;;;;A<7@0944<8$69=7??9=@0BAC@>?<4;A7==>59?BCA(2653;==C;<4>@?A@8?::B??C??CA=.>@>4@@;?=>A=?A??>==9=5>9=BC<=BB9.>::@<>B6@>=9>=-=/47?@?&757?<:>=?==86:935A??@=-5<:7A@B<<9:;69=>9>?6<7;<>?>=7@=<:1>3<;<6=?=9<:95>:&77;8:AB1=A?.A@BA?A?>59<7<<:>CC8A?0=7ABB<8C.=BAC<;=?;C@@=BA>37=98990>=8?=?39?A,9=?>=>B6??6;=:@8??>BC>@4<6>7>9>@,93::7>90:?>6;?AA??;@>9A?@<;@=9>:8;;==+??<94=<8<=A<.>@A2?59*=?AB@:@6B>C5=;2<,4?AB<:=0:6<=:B?BA>B=B,570;=;C6A<>>C8?16;@A;@>=@0B?=7>9?6;:?4<<<>>A?@A6@@;AA@@C2CCB;=C=5=;8A@B;366@9;56%8;>88;B9<<7@:<;?A8<>@@:>?.@94>88;<59:?>=;461,9,(64A;BB13>AA;>@5>=B<789>=2:<??:84;=:=>?B>3@6>5684=>19=6>3@A9AA5@B@5A;@5A,:07,=@>/<=?:9BA987>;?;<6=94369?9A;8575;?A:>-9C@>>=89?C>28941;;2.==?:6=A@B?5<0<9?8<=78;7?@-=?>9B893)/72*2<>;ACCCB:6&>91155673.,&15(,3578/,;=6>>78,76:9=>@=5?994=77588:79;B;A099:=8<49@=@;??6;;A=@;>;;62?1B:7:;:5A@A=>@?AA;:A:?<,?84;<>?5<<05@<:B?8?29@9>4:;;=:AB4?<>?C?79)@@?C@@A@?88696<:=?A;:(,4@B??A?@;6/:$9978<*4:@BAA?A:6<:A=9;<3@>AA@&66:8A/4;5?>B<@8514/88.::8>?6=8>A3306817599>/=>0@>?:B0==:3<@@.;14;5@=@=;<985255=/?>835:>=A2/947=38;:9=+;.@@9;;4A8860;15;+>974+0<:<09>=?A'5@@7:?A=>7@9>8:95668:7=:<=?=?7<=?94:846=8-/25;:?@A7<<@;<>1:?6;794/4&9820831'45==A2=9:A>;;;;?;>2>@==:95,8>:>95>3@:;96?75B?BB=;8/<<??0<=67?E>@;@39=3>C>$0:?<=%5@C?AF<4:DD-5<-098913>B?@8?AACBA=CBF:B;8F8:ABC1ADE7A6BA<>>>,9A?;E>@>BBE)C@<@7FFEAB?<853=69.?<9D@=@?D@E3=EC8FB25589?>>41=@>DCG:DA:?:?>4@9>DC6BE;F?=@A98>,ED>A1A>A@B:7:4=9A?C=<;>;:=@A,<@9ECD8;1?:+:34;.8;8A>E=>>AA;88@@AEEE?=C::=CB@7B?.?8:=@>9:EA?66@@>E@EBDF><90=E=ABCD@BBDA>A?EBDBDC@:DEC:?@9:BA>CBFEB>BAF6C@A?A>;?CBE;>DA;E=@GB;?BADBCFCED9D?AGEBB4>=D=B?6;@;<@==*6>@DEFE?@5=BA@B=@2E?@EC@?5=5?=ACAE:=AA8?>CEG=>>>3;>@=>67@=>60C67?89>>;8:/>B:?A39)9:7AA?,<:7>??A7-6061721<;A7D;1@;5D<@=A;>==:89AD9:B3<=7;<8,(4?CD8=FB9>2A:9879A>9639:>;<:0BDA:=:6;-A9;;?:@5B.29.7+5=9474?8?098:>7;CCCA>>?AF<-@B09;<4B?=C:G:>@?589=9>46=<;A92<=9@=87215<=<6793@9BB9=@1;3>645@@:=B@>;#:9=>>>;::759;<74*,1470=61.0:<9@=>6;=4<52)5:32;@,=5:;442<;;9>9=:=#257477<59=A:%32:88?>@=:?CABBC;A99<:;6)BA?C9A+<=7/63.B@?5>?CAC72>==CA758 @rCer/1668/25_1743_CCS ATGGGGGACAGAGTGGTCCGCCTGAGTACCGCCAACACCTACTCCTACCAGAAAGTAGACTTGCCGTTCCAGGAGTATGTGGAGCAGCTGCTGCACCCCAGACCCCACCTCCCTGGCAATGGTGAGTCAGCCTAGGTGGCGGTAGGGGTGGGGACGCTGGAGTTTCCAGGTGCCAGGATCCCTGCCCCCACCGTCTCTACTGGCAGACACCCTGTACTTCTTCGGGACAACAACTTCACCGAGTGGGCCTCTCTCTTTCGGCACTACTCCCCACCCCGTTTGGCCTGCTGGGAACCGCTCCAGCTTACAGCTTTGGAATCGCAGGAGCTGGCTCGGGGTGCCCTTCCACTGGCATGGGCCGGGTACTCGGAGGTGATCTACGGCCGTAAGCGCTGGTTCCTCTACCCACCTGAGAAGACACCAGAGTTCCACCCAACAAGACCACGCTGGCCTGGCTCCGGGACACATATCCAGCCCTGCCACCGTCTGCACGGCCCTGGAGTGTACCATCCGGGCTGGTGAGGTACTGTACTTCCTGACGCTGGTGGCATGCACACTCAACCTTGACACCAGCGTCTTCATCTCCACCTTCCTCGGCTAGCCAAAGCAGCTGGCAGGCATGCTGCCACACACCAGCACGTCCCATCTCGTGCTCATGGATTTTATTACAGACAGTGGCGGCAGTGGCTTCAGCCAGCCACCCTCACCTGCTTTTCAGCCCACAAAGGGGACAATCACGGCCCAGCAAGAGCTATGCTGAGAGGGGGAATAGTCCAGAGCCAACAGCAGAACTTGAACTTGGAAGGGGCCAGGGTGGCCAGCAACACAAACTATGTACAGGGGTGGAGGGCTTCCGCCCAGGGCTCTCCTGGACCAGGATGCTGGGCAGGGCAAGGTATCTCAGTAGTCCTCCACCCAGCCATTCTCAGAGATGAATGCGTCAATGACTTCCTTCATGGCCAGGTTGGGGATGAGCTGTTCCTGGGTCAGGGGCTCCGGGTCACGGGGTCAAAATGACCCACGCGCTGCAGTGACAAGAAGGGCAGAGGCAGTCAGTGGGCCAGGACCATGCTGCTGGCCCTGCCCCCCAGCCGCAGCCTCACCTGCAGGTGCTCCTCGATGTCCTTGCGGTCGTAGGTGATGCCACTGGGCGTGATGCACGGCTCCGCATCAGCTCAAAGCTGATCTTACCACACAGGTAGTCGGGGATGTCACGCTTCTGTGGCACAGGGGCACACGATCAGAGGCTGGGAAGGGGCACTGCTCCAGCACCTGCCACCACCGCAGCAAGTGACAGACACTCACCTTCCTCTTCTCGTCCACCTGAGAGAAGAGCTCGTCCATGTCTGCCATGTACTTGTCCTGTGAAGAGTTGAGCACTGCACTTGTGCGGGACACCCCACCTCCCTCCTCCATGGGCACAGACCCAACACAAGGCGGGATGCTCCCACGCCAGGTGCACACACACAGACCCACATGTGGGAGGGGGCACCCTCACATGCTTAGCCTCAATGCAGGCCTGCTGGGCCCGGACGTGGCTGTCGTCCTCATCACCTCGTGGTTCCGCTGGCACTCTTCCAGCTCCCTGGGGGTTGACCAGGAGCCAGTAAGAGATGGACCTGGCCAGATGTCTGACCACACCCCAACCTCAGGGCTAACATTCATGCTTCTTCCCACGTTTTCTGCTCGCCAATGAAACCTTCAATAAACGCTCATGT + <@-?@B=<@@B@@9:FD3B:8=;DA@8;2??.?*B0-/<78486D?;.<8<&;/DE.6@5>IHCJG@E%?@7FF9BED9C8IIFE5=;>DE@H>3&AF;*$C&BBHB@.I2)D>@2GJEH*JIEB=AKHGHG6:2IG:FD3FD:GECG?2><;H+@BFE@6HJ@D7II3?&E)E@HIF=;7C?:CG3IC?/AE>IHDAJ@C@J7693%?D@5H?@=;.A?H@?9HFB9A0E4CE+AC5CA7>/79D(6<F@A;E>ABF)ED9-D63:>9@&D:D1F+IB@A.E@87;==A8DH??<97)ACB>%DF88A>6EB769-4F4@AHIEC75E;EEEC<>CBAB:B8JE&CDI/GCF7G/9@E(C/GFCH7FAH?JA23DBG@:*=@2D957=>4H;@HA=9>3EEBG?DGB7IH7JC=6'G;=%B+&=D>1;,6:FD6II6$/A-@A>84C3%FFHAC>G@B;9-G*DE>?D?J@28>CAAGC0@=AGF3AAC=@5GDCED&A2C=ACD>HGAE=D@1=?:@3>@>CD6C:@>A9G43:B:3E%;=.@F;&ABD>65A@A.C*2=.5@?1>=D?GE<>9@C;*A'@ABA?A;E=B7>?<CCADGGCD9;ACB9>>AE<=9G+GEABBDH*9AA;>/A'CDAB,;3EBB8=,F>?E>60<@==CA>CADD6A9?;C>:7-0%8BF:4:%=:??CF<>>?E9'J<;G-4DBCC@?G3;6I:IIH>*GCDC@>?2FFD?B8B:BB6FFGFF(C@>>6:FCGIA7EE5:1A?EC?B7B?D>HAA:-EA.E4.9;3DIHFIBD)GFGGDH>BC@,@+CDD9EFDF0E<@FC9??54'F;DEH7@@2?I?$@;+BD83==5=DEDFFGBAHGD?F<@E5D>GAE9H=?CG=.EA;>CBI@CDGJDIE?D9EF(GHE@C8CG0D<@GG?>+?:B7A9>CG;GC8::D;<;>=6F598E8JAAG99GFG=.D;*EB/.A<3H>;&>9;0=,CH7FI4G4==1H(A90JI1>;34(ECEF98B>)C>;5=9724;1>3,31JGC;=ACD8G-8&ADBGD<8HI;5@B=>HF?J?I2F=E/G>IIB0E4E>FD<$@A1GF5EADD5.CF2:47=B6FC99C0,$A@2:;J@JD?;@1KKD%GJJG-J<=>KA8HC9>C5JIIDKE=BDC:IJ54$GFDE;0KJI=AIGBHG*IBKFC,DB8B-CF2=>9CIGFJJJJJE, @rCer/1669/1986_62_CCS ATGGGATACTGAGCTGCATTTGCCTTTACTGTGGAGTTTTGTTGCCGGTTCTGCTCCCTAATCTTCCTTTTCTGACGTGCCTGAGCATGTCCACATTAGAATCTGTGACATACCTACCTGAAAAAGGTTTATATTGTCAGAGACTGCCAAGCAGCCGGACACACGGGGGCACAGAATCACTGAAGGGGAAAAATACAGAAAATATGGGTTTCTACGGCACATTAAAAATGATTTTTTACAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTGAAAATGTTTCAGAGCTGGAGCGGACCAGAGAAATTGCTTGCTTTAGATGAACTCATTGATAGTTGTGAACCAACACAAGTAAAACATATGATGCAAGTGATAGAACCCCAGTTTCAACGAGACTTCATTTCATTGCTCCCTAAAGAGTTGGCACTCTATGTGCTTTCATTCCTGGAACCCAAAGACCTGCTACAAGCGGCTCAGACATGTCGCTATTGGAGAATTTTGGCTGAAGACAACCTTCTCTGGAGAGAGAAATGCAAAGAAGAGGGGATTGATGAACCGTTGCACATCAAGAGAAGAAAAGTAATAAAACCAGGTTTCATACACAGTCCATGGAAAAGTGCATACATCAGACAGCACAGAATTGATACTAACTGGAGGCGAGGAGAACTCAAATCTCCTAAGGTGCTGAAAGGACATGATGATCATGTGATCACATGCTTACAGTTTTGTGGTAACCGAATAGTTAGTGGTTCTGATGACAACACTCTAAAAGTTTGGTCAGCAGTCACGGGCAAATGTCTGAGAACATTAGTGGGACATACAGGTGGAGTATGGTCATCACAAATGAGAGACAACATCATCATTAGTGGATCTACCGATCGGACTCTCAAAGTGTGGAATGCAGAGACTGGAGAATGTATACACACCTTATATGGGCATACTTCCACAGTGCGTTGTATGCATCTTCATGAAAAAAGAGTTGTTAGCGGTTCCCGAGATGCCACTCTTAGGGTTTGGGATATTGAGACAGGCCAGTGTTTACATGTTTTGATGGGTCATGTTGCAGCAGTCCGCTGTGTTCAATATGATGGCAGGAGGGTTGTTAGTGGAGCATATGATTTTATGGTAAAGGTGTGGGATCCAGAGACTGAAACCTGTCTACACACGTTGCAGGGGCATACTAATAGAGTCTATTCATTACAGTTTGATGGTATCCATGTGGTGAGTGGATCTCTTGATACATCAATTCGCGTTTGGGATGTGGAGACAGGGAATTGCATTCACACGTTAACAGGGCACCAGTCGTTAACAAGTGGAATGGAACTCAAAGACAATATTCTTGTCTCTGGGAATGCAGATTCTACAGTTAAAATCTGGGATATCAAAACAGGACAGTGTTTACAAACATTGCAAGGTCCCAACAAGCATCAGAGTGCTGTGACCTGTTTACAGTTCAACAAGAACTTTGTAATTACCAGCTCAGATGATGGAACTGTAAAACTATGGGACTTGAAAACGGGTGAATTTATTCGAAACCTAGTCACATTGGAGAGTGGGGGGAGTGGGGGAGTCGTGTGGCGGATCAGAGCCTCAAACACAAAGCTGGTGTGTGCAGTTGGGAGTCGGAATGGGACTGAAGAAACCAAGCTGCTGGTGCTGGACTTTGATGTGGACATGAAGTGAAGAGCAGAAAAGATGAATTTGTCCAATTGTGTAGACGATATACTCCCTGCCCTTCCCCT + CE@='B8ECBCB;BCCE>FFEEEEE@BGFCBB>C6CGE>AE4?DCCA>@CA7FGC5E?GFADBD>@?D=ABDA7GEECF>C@CCCG-GEGCE>@;H9AC>FGCG@DHJJGH@HIIFJE@IHJFKJKGEIH?E2FEE/IJAJJB@FF+EDE=EHGF=B=A;A;EE1CCE;ICB=FEG:BIEEEFFFGDFCJB5HGH?=@CDH;?AJEH8IJGHIHG8JJGBFDB?HGGGHE;FDBB9GIGG5F7FJBHGCHG?BCFCEIBJEEC@CCDEDIC?CEAHJEHGF?FBIFHFFFGFF>EJDIEAEGI1HGFG2G?HHHIFFEC;JJKGEC>HHAGGJEKJ@CKIJ:KIKGHGGI@JJJJD4G4?9FH:GFEJCH.GCEKJEAJIHIH@AI7JKHCKJFECI;D?IK;KHK@HFBHKHKAJKIJA>FGC;>9JHKGCJGHKGJGKIBHEHIIFJFCIDIJJI;IJEGFAIIGCADFJH3@HF5AHDGF%GFI5G@JIKFHGJIDHBDB@8CHGGDIHJHHJJIJJJJCHIEKBJGIIFFKKIIHHII@EGKBCI?KJDFJ9BIAFHHKJAIGF?BJKKJKFKCGHGIC>?C?KIEJJIICIKFEKKKKK;JKKJJHKA:HGHFG6JJ;HJHJKJKDIKIBK:DJKCHJ;CJ,GECKGICGGKJKBHBHJIJKG>;IGFFHDI6HGEGK99CHHHD;8GJIFCKFKBJDEG@IKIKKFHHIFDDKGJJIJGJB::8F@AJJDHECFJIGCDIDJKJCJJJGJI6KFIJGJFCEIJIIIJ5JJHKJK5JIKKIIK?FBJGJJIDJJFFHKIE@EKIKIHJDEJII@GKJKGJJKJJKDHJKHEGCJIJIKGDHJJKJKJHKKH>GK>DHJDFGIGIIIKJDJHKIH@JJFJGKDKIJAKHJHEJFG5IJGIG<-@>KGGJ>GAI;H=GJIKIHFJKH?AIEIDGDB9CF;GJJJKGJKI+IJB>FB==;9IEHHIIHJ2FKBB4DKIIIA;KEIIEJ7IJFFJDFIIIKEJCHIJIKKKJKK:IHFJIKJ?BFKCIDIDKDJKJJ=JI?HIHFIJKI8JJIEHEIEDE??IE>E3:?3>?58:==@3;<>;693=679;?88;;>;:AA=.;37?><>C8=:??7=9<::<46B<9><9?-D;2>77FBA<;::B8AA5A:EE:@8=@3:?><>EB?A=E:4(7:=6CD=FC@;F?;C=:@::2:>*6E:4CC507;4886;<9:>:?61@7AA3>BG=?B@?=C5>@459?AE*E@?;=??:.CE?BHJCB7E;C?D:.B=9?>=+C4BAA9A::@9:@&::876>A.@=8D>@=AC@=@B94@?<:A-:?8=>?>A-B::=:8>B6=:DF-C=<:2B;;A?B9AFCB:?@<8?@::@=8/4<@EAB=6?@1:/>;AC<<&?:?BCDC6@BD;E<:@:DA>A>AE(C@:??4AD+BEC7G??C:8;@=C@A74:CB?A=4@DCC>ADA5;=99/<=8@<>A?D18654<1=E@@AE>CD4=;28>A=9?9279A@CF=BC=CC:A6?CAD?EBD1=:5=.C95FD=G>9A-:9?=:>3;6>4;@;59/38<:@=C6=C@5?C:@4@6@:D?==?<@C9>B?9(::<<<1@?>8AED?CFDAA<=C4FB>F@F7=AB&HHB>A?A@/5;=4AC8DEA)@F>GAB;;,8A6?GC?4FAC8=?3?6@F>@C8?<9>GHCAF/C@F>5@HHDACB.;2CA:A=D9BAHBBJ3>DAHD@BDH?HE:HGF@@FHDFEGAEACEHBFIB@<5@;@@45@6;@=CBB1AF0;FF-C:H9BCHH3CHFG?CEFFDCD>HDGFBGHD4HJ@7B2EBFG6F9F?=6G;961.2C?@GC9;FEC@B8EGBB25.>7E8F@>G>>>E+GC8EA=B=DA<E==A4C@6C?F,IECFEA6E=F9@?FDF=?@C::>A<2ID>@;BCEDBEC3C/A7JD@HF>BIII??CE?BC*<>C>88@@<;57>GFE6DACF*668CDDEFFC';>=DGEHHFF9BCFGBC;HBDHBFAE@FG>E<@CGFCGEEEGHDFIE6:@>(:9?24D=:4EB@E>D6GIAFAA99ADABA/?8?DCB?;;D=9:?0?B;5?*=>CB>:8:>B>C?@A;6E>6E9<=>AF9DF8AACAB=-8<;8>1BC@C=:;CB3>A;CA69BFCEBF<;5A>?@A@+;=/7;DC@A>@DE@?018:<7A><:C79:>,.>>?=BCD8CCCBE@9C7B?<>CC6@@>=;/C@?@@<:6<=8@;;<:748;:77)@/=:??>78=:A<;;@?>?BB@:@2868:;=23=(:@;=-82A@;;@A>@:7=;7<1=858@=@/8=>47>@>A=>>9=&;@B3@<@A=@<9<5,4;-23>@+9458>37>8<>?=<#=;>?:;9@?4<;??==:@BAA;>AC2?@@?=6?@:?@ @rCer/1673/2831_58_CCS ATGGGAAGAAAAATCAAGGCATTGGGAGGTACATGGGCGTAATCAAGTAGTTTTGCTAAAATTCCTCTTCCTTGGTCTACATAAAGAAGACATGGGTCTGTCATAGAATGGGGACATTAGACTGAAAACTGGGACAACCCCCTTCCTTATTTTATAGAGACTAGGAGTTAAGGGGCCTGCCTAAGATTGCAGTGATAAAGAACTGAACCCTAAATCAGCTCCCACTAATGAAACCCTACTTCCCTTGTATCTTTTAAACTCAGTTCTGCATCCAACTTGAGAAGAAAAAAACGTTTCTTTCCATATCAAGTCCAATATGAGTTCATTTGAACTACACCTTGCAGAAATGCATTGCCAGAAAGCACCAGTAGCCTCCTGTCTGCAAGCAGAATAATGCTGTGCTCTGGGGAGGGGTCATTGGAAACCATAATGCAGAGTGGGCCCCCTACTCCATTTCCCAGCAGAAGGCTCCAGCTGGAGGGATGGGTCATGGGGCAACCTGGTTCTTGCTAACTGCCAGATCGAATGTGTGGGCTAGAATGCCTGTCCATTTGGTTAAACCAGGCTCAGCATGTTTGCCCTCAAAATGTCCATCCAGGTCACAGCACACAAGATGGGTATTTGGTCTGCTTTCACCCCACCCTGTACTACACATGAAAATTTCAATTATTAACACACTCAAACTAATGGAGCTTGTTCACCCTAGGAAGGGGATTATATATTGGCAGGCTGCCCTGGTGCCTATGTAAAGGGCTACATTTTGGAACATATGACTTCCTTGGGACTCTTAAGTGCATACTGATGGCATGAAGTAAAAGGGGCCTCTATGATGATAGGAAAATCAGTTCTTTTTAAATTTCTTCAAGAAAGTCCAGGCTATCATCATAGTCTTTCTGTGTGACTTATTAGGAGATAGGAAGAGCATTGGGAAACTTGCACAGCTAGCTATGCATCTACATTTTGGTTTGGGGTTAGTTATGAAATGTTCTTAATATGACGTCTCCAATAACTTCACATAAACTGCCTGTTCTCTGAAACCTCAAAGAGATAAACTAGAGTTAATGAGTTGTTTTTTTTTTTTTTTTTTTTTTTTTTAATGGGGGTAGTTTTCTATCTATCATGGACTCTAGTATCTACTCCACTACCCAATTCTGTCATCTCCAAGCTGAGTTTCCTCTTCTGAGGCAAGAGGCTGGAGCAGTTCTTTTTCAGTTCTCATCCTCTCCATCCCAGTCCAGTATATCAATCAACTCTAACTCGGAGATGTCTAGCTGGTAATGTTTCTAAAACTTTCACTGGATTTCTTTAGGCATTGAAGCAAACATTTTTTTCTAAGAATTGCTTCTCAGATGATGATATCAAATGTATATGCTTTTGCAAGTTTGAAAAATTCAAATTAACCCCTTTTGACTAGGTAGGTCTTTCTAAAAACCATTTAAAGCTAACTGGGTCTTAGCATCCTCCTATGTATGGAAGGGTCAGGTGGCCACTCCAGGTTGGGTGCTCACAGAACCTTTTCCTGACTGTCATGGAAGATGGTAGAAGGAAAATGGACTGTCTCATCAATACTCCTGTGTCCTCTGAAGCAATCTCAGTTTTTATTAAACCACCTCTTCTGTGTTTCGGGTAGCTATTTAATCTGTATTTAATCTGTACTTCTTATGCCAGCCTCGATTTTATTTGATTTTTAAAATTAGTCTCTTCTAACCAATGAAGTGTTTGTCAGTATGCCCCAAAGCTTGCTCTTTTGTGCCCCCTTTTGAATAACTTTCTATCCAGAAAAAGAGATTATTTGGGACTTGAGATCTGCAGTGATACCAACTTATAGCAATGATGTACTTTAAGGGAACTACCCACTATGTTGTGATAGGAGAAAGAGAAACCTTCACTTTGGTATTTTTTTAAATCGCTGTTTATTTTTCCGTTTGCTGCCCAGGAAGCAGTGGGAGGTGGTGACAGATACGCTTTGCATATGGATTGTTATGTTTTTTATTTGGGCAAGTTTAATCATGGAAAACTCAAAAAGAAAGGGGGAAATGGTCAGTTTAAGCCAAAAGAAACTTTCTAAACAATGTATATGTACACGGCAAAATTAAACAAATCCAACAATTTCTGAAGCTTAGTGTAATTGAGTGGTGGTTGTTACTCAATAAAATTATCCCAGAAGTGTTTCTCCTAAGAGTGAAGTTCCCATGAGTCACTTCCTGAACCCATTGACCAAAGGTGGACAGAGACAATCCTGTAGACCTTGACATTCAGAAAGATGTGAGCTGCTTACTGATCATATATGTATATGTTTCTTTACAGCAGAGGAAACCATTGTCCACAAACTGATGTTCTTTTGGGGTTTTATGTACAGACTTGTCCAATGATGTGTGTGGTTACTGTGAGTTGCTGATGACTTTGCATTGAAGCTCTCTGAGTTCCTTCATTTTACGTTGGGTTTTATGGAATTATTTCAATTGTTGGAAGGCGTATGGTTCTTCCTGCCCTCCCTCCCTTTTGGAAATAGGAAAGCAAATGTTTAGAAGAATTCCTTTTGAGAAGCTGTGTCGTGTTCCCCGTGAAACTGAGCAGGTGTGTGTCGGTGCGCTAAGTGCCACGTGCTTGTGTGCAGAGGAGGAGGTGGCCCTGCCGGCTCCGCGCTGCTGTGCCTGTGATCCCGACCTGCTCCCCGCTCCTGTTGCCAGCAGCACTCACTGCACTCCTTTGTCATATACTCTGCATCACTGTCATACTCACAACTTCATGAATAAAGTTGTGTGCTTTATTC + 3+12*6-56656444325-5-1/41033.1..0366.568776695564898;762894:1;4:9379280999:798965377-89828617655:8:6::80+79,5898)873749586.99;;27598,17778468%5-94988788+5333745666;:7:99;249:283::;982+5-4265+8882474+,2.1164&44(063177253236.888826596426/898:026)93:5788798&1:26.5563899)64779436;620*6/975673.%5688119537963323739:;4789:38488556;93:4777::795638:8::4529689298/58;87422943/4,/:829384:8:65258::986387298+8397,89:78148;956896571990911/4,398466419:-2765(9:8196399.:;487759;9;64-:8:752859:86/5784888697;56:3749:16/9:7499;59:8:69::9:88766935:;36877948:;8686;469;3933%4:2;74978989803.648'307.48776*9999/6482699:9::983:874:65:88967987&;87239:6;7:88885771226/85867457/0899/85382.:92849.2(025489;:89;69:16265456597299+1339+342+..,/'//5$$2-1344369992%4185;18::959929;698985688+4,92446598569464:3984378:;48/4748716099545045::;5507:4*/38&:779405:93.8578.:98,7869:00230+"79%,2+-87663474)57:52949:8981185592//2.$042879:96925;78838+7834150148466.83+27&69212*4177857::6:4973/888899;5;69;3685);46,:6758;;8265(07.83737789:6:96/44,8577-80-5317*6:94421;627439;;:673997.::9438717552744'9182477236676755556677877565566766$,3-02/0(-34546/4.*59468882:724763/1708555955,87:9:46917573914869266:49:56557:,529955939:;852&45;578969:3:98,68877'857;::76/-53:9:49999606838+310997(8656:;457::986:8:/474174696977477;8::;86479;2118972:8:445761&78%8:368;778579692697788::(33;5797:.548460:::9583.1:89979925892796959;66::6:765'087890:5561&:7748:90958,444436+&6725794+8,)653$767;48977532:/.-474676787452257:76562556748.44%163877:/9745:955:6949941+7:73-7:946$&23';869848:967:678743.5.69:957:::9116/237:6/587668*97:9:5::66462413776::9342:9747665&46264&;739765677995755$8;9398837:;7284898:7.:9774,1561281/41182656894677:9887'59:5688:78444852147.&-(&#/373612-60/213367---024321200/&521&,845753454(8765588,:68-9728916;92:3:779679:6;3865887899,5:229;67018015:514-10/3716'24/15576655:4729555949379/9378498/51+1579+6356542961571/&67:2:49/9710/*:267657595%46*9:567:66475875*72196/1.76:8195520499569918:533132)96/74/476:55::538:;714'29/778::::60968/88-86,77806-96302)256045.4888,365'7;8:440'-73117678/8527/769/7;71,52+/69:047+56338630+586891899;0;9783437+5848506):;778762995751207:42,2-3443)9893/75403..44486)6/25644786594197.6767:15993)13%77.64,-/28512575)54486/-0+.7+4464:;/80+8189/94:88972906948889324166:;/5389804.46438356/69869436-370854154)66/98446+7)9961:6968552-63.2345128144$.4/,44:43738.40.1::9+205544646968655380175673324314:7058,7698988594689357:5765;5/58787197//0+6/4222378:5)-868/-1$653&27:02591.35,35.4.42222858227285515&1:580486828840/87'335-()55.240213*,498-78;;98/;823-3'0*/32'6668842118818767116720,/-01)4,&7/4/,()*4502045/0520/0-*13-6-0),.-0-'/.1.,(13-2463579503..2'2/6451.6725313533046585/2/5.2084:7832011877,2/25229920912846632398:66910,31,11.6-0,14/2651998198766+96253141.57*65.76968,7;;-96/54-37:45616$5 @rCer/1676/1531_58_CCS TTTAGCATCGCCGCCGCCGCCTCCGCGCCGTCCGCCCGCGATCCCTTCGCCCCCCAGCTCGGGGACACGCAGAACTGCCAGCTGCGGTGCCGCGACCGCGACCTCGGCCCGCGGCCCTCGCAGGCGGGGCTGGAGGGCGCCTCCGAGTCTCCCTATGACAGAGCTGTTCTGATCAGCGCTTGCGAGCGTGGCTGCCGCCTCTTCTCCATCTGCCGATTCGTGGCCAGGAGCTCCAAGCCTAATGCCACCCAAACTGAGTGTGAAGCAGCCTGCGTGGAAGCCTATGTGAAGGAGGCAGAGCAGCAGGCCTGTAGCCATGGCTGCTGGAGCCAGCCTGCGGAGCCTGAGCCGGAGCAGAAGAGAACGGTCCTGGAGGCTCCAAGTGGGGCCCTCTCCCTCTTGGACTTGTTTTCCACCCTCTGCAATGACCTCGTCAACTCAGCCCAGGGATTTTGTCTCCTCCACCTGGACATACTACTTGCAGACTGACAATGGGAAGGTGGTGGTGTTTCAGACCCAGCCCGTAGTGGAGAGCCTCGGCTTCCAGGGGGGCCGTCTGCAGCGCGTGGAGGTGACCTGGCGAGGCTCCCACCCTGAAGCCCTGGAGGTGCACGTGGACCCTGTAGGCCCCCTGGACAAGGTGAGGAAGGCCAAGATCCGAGTCAAGACCAGCAGCAAGGCCAAGGTGGAGTCTGAAGAGCCGCAGGACAATGACTTCCTCAGTTGCATGTCCCGGCGCTCGGGTCTGCCTCGCTGGATCCTGGCCTGCTGCCTCTTCCTCTCCGTGCTGGTTATGCTGTGGCTGAGCTGCTCCACCCTGGTGACCGCGCCTGGCCAGCACCTCAAGTTCCAGCCTCTGACCCTGGAGCAGCACAAGGGCTTCATGATTGAGCCTGATTGGCCCCTGTACCCTCCGCCGTCGCACGCTTATGAGGACAGCCCGCCACCCTACAAGCTGAAGCTGGACCTGACCAAGCTGTAGGCCTCCGCTGGCCCCATCATTGCCAACTGCAGGGGCCCTTGGGCCTCACTTGCCCTGAGCCCAGGAGTCCAAGGGTAGGGTGGGTCCAGCCTTGAGCCCCTCCACCCCCAAATCTTTCCTCTCTTCCCAGTCCCACCCCTTGCCCCACAGAGTCCTGGGGACGCAGTGTCCCAGCTGGGAGGAGGGAGGATTGGGCGCTGGTTCTTCCTTGTCCCCGCTTTCTCCGGGGCTTGCTACTTTTTGTCTTCTATTGTGTGGCTTTCTCAGTATTTGAACCCCAGTCTGTGTCGCCATCCTTTTTCCTTCTCTGTCCCCTCTCTGGGGGGGCTGAGGCCAAGGGGGAGCTGCATCTTGCTAAGGTTTCTCCCTTCTCCCTATCCCGATCTCCAGAGACCCAGCTTCCGAGAGATGGGGTGTGGCATCTCCATGCCTGACAGTGTGTGCCTGGGGCTTGTCTGGGGCTGGGAAGGAATAAACCATGTATATAAAAG + 5/,.00)+,,*&)0&-0-642392+>:6;146.=99.;88:1@>>E3B@>C9>?>(;:7=>;1153;9ACCB5>8,,::1>B;;?88>@8?:9?926<10:6961.:76;=>;7<5@CA::@=4;;3>A8813?>+5>618:;?@=22981>876>90305847<=:958:7348<98296-<9:1?;F6E>C?FA7=A:7:;AC;D:9FE9BF@GH:D;77B?8A57;=B4>89;4>3A32@738@:0??6;>144987?=;E8;AE<@?=;+=:C&D>JCI>HB4?BBFC4=EGHH>=GJAIHFCFD@BE@A*>9@5@8GGFCF<5=G??DAE=BF>,G==CDG8BDIJFCF5HHIJE:;HCKHAFA4ACD3HEA@I@0IJDII?E@BABEID/F?ICJCDB@EBB<K9ADEDG?G:FAF?D7C9C@BC@ACB>=F;BFBF8DB=A<49:>;A5?94>=CD=>=47B>.B?<=0B7D@=>@==):D?D@;HIHG@@18AB?DD@EC9??A0;>DB=8@BEDA14;6??CCAHDHDEGJBCEEHC0FA?AFA<>,D@@9D@>=9A:GFB==5A<;=:?;A?=BC:DD376>9=B;D@54?1GFG@F;@EC'>@;9?GECEDC>97?E>>FIHEFAB>6?F4DE=GH6IFIIEDH@B4<@;E1=?,@<9&?IB=<>DJ?J6F>FF@HJE?<FGI1JI+=BH=?5BFFGE;-GH9FEIFI0GB7@C>D?F2:C0=@CEBB:=B<:C)F?HJJF.CC@@BAEH>?>@DGEIAF@>;CD):A;D3=+BE$GG?HF>IJHGK5E7>G;D-I0JADII%EDKK9@BI6JJH&@K9FJ0EFKIAH2EBIGDIHD=6CGIIFACHJ;CIFFB=?KHBIIFKHHCHK?%2F=FIIKKEEBG8JKKI6KGKDKIKJHBGI@%A@FEJICEEGH(KF@JC;G5KBKJIKBGGHEE=BIBCGKDAD>DDIJDJDFHFIGHDHF9(>>8D.@@FABG?IG@D$@GB@CHIGGFHHIHHJFE@H<DH)A @rCer/1678/2262_59_CCS AATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGCAAGAGGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACCAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCTACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGGTTCCGGAATCCTGTCCTCAGCTTCTTAAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTTACCTAGTTAGAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCACTAACCGGCCAAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAAACAGAAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGGCATGTGGGAGGCTTTTGGGTATGTGACATGCGGGCTGGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCCAATTAGCTGAATTCGCGTGTGGCAGGAGGAGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGGAGATTTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGTACCGTCCCCTGCTTGGCCCCTGCATGGTGGGCCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCTCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGACATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCCTAACTACTGACCCACACCTTTTGATTTTAGCGCACCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGGAGTAGTTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAAACCCCCACATTTTTTCTAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACTACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + $%),'&%)+2/)++),&)/(*,1011,*-'.--/)$-'+''%/-*.****/11.,1.-,&&',+**21+**%*,-01+.++),0-&.,/..-,,,/1/()&(.+(,,,0%%,$-/')*,,0-1/0../0+%.-0-++%+,',*,*0***-&*&#%412.240/33,15/0,,(&')'-*%/+54420351323%.'*)*033/,++&&+)',25(+4%44/*)$//(/5342/61450.1324(+1.4/1&.6440,(((,)/3+*11,.,011,,-/,,%/33+523.(*(2)2-.++464511441/.0+$33**&)''$+-0,///1*,2&353(&'*$*%21*1+4103$&-/))'-,//&*524/./6-30*,.()+'+5+'28)*+&%*.6'322874.7274-*)&'")+,*.2./4./,*/%5//31384*4*-4656.-1/7--163151340-7:9450304%/0,2.1/45+,1)/2(,'&)(2,23343,*'-0)2956076143)57.98-1*83.,31344725'///4/*97+780053.332303,811+1-72-1'./1/(+$+.,1'0**-%4,.0**4.00/05698::6.16*2+21-&560.*37+//3+341&281)&,+2')*3%/4.3-)-/0%(/1/7/-1*+'&&150-/,+.(.66,640'-.&.*.*,101(+.42701:97432,+218232+/.*1-*3422+#&''-($*&+%*%$##,-)'2)(-.849474.2.&121&-8;3220)),.#.-,,/.1%12254733'4365658&0-5/217.47+0,*.*.8618%,)0*#)*$-'3/',-.52/)%$+0/5))&-+52424/42342.,3-$(04343412(*&'0-/+011120-.*&(,%%.&3971,&1*,(.814.34+9452:844,201-/),/+$0%-0/7,)-/-//*2(223+-,-.5012:14-/63%899:79456528/,-,3--/*($"*#&-(.012/56574248,4.7736198;4;124:65)++,,),*%+.1&--/.41,)0)-.41+2/-$)1+'0,0367-,045:860536980'2#*1/2117668:53:3.423/54.//+'%+,30..*)32%20,4,(%%($-0*-,00/+*+&)/+$',&**'1/,5053.*7-843%001)&&&',,-/0(//4../(.2%(430/.-+)(('-'.*/+,0103*0-*.*&,25&:5503'&%/4-:6:959:3433.0&(*8-#)#.%461052/3'.223441./)&++23+.-1212*&0/(-2,11+/++%+/*%.0+.,'&+%--++,'%)(&%&*.+/50-4,%0,.,0%+&,'('$..&%$+'%%'""#&'%#&*'$#$"#%&%'.,$(#&'%'&)%.))&%)/'&'*(+($,%()(+).*0.1,2120,.,/10/..,&0+')*0.*/'),1,,+))&*%)+$(+**(+(-+&'/-0,*')$'-02011,)'*,/+%+,(&-'-'//(+,*0.//'**&*,//+00,-11*/,.)+,11.1*'&+$,+&,,,+)-,-'+(1--//'.*,&)),/).1,'+,0)+/($%#('))*+-*,/-2.-*/')(*+%-+*/,*2+0+-)+*+'-*.%.+*)(./11.1))&+)&-+*(&(++,&*0-112+-)),&$(10*'%'+,&,(+-+1.(122*&+)(,..%*',/-,-'+*.,.++/,-*,001.-))*,)(&**)*(&#(++'&++&)++&00(,,-.(),*&+*%+*)'&*'/./),$+/2-($!)/$&(#%%$&)')-,*'+*($0,-)*++&&&+)--+*,&../01121112/*&.-*//+/0%(&/0'.),&01100-.,+1'01...-/.',/001..%/+*+0)#,,.,0+.*+02+*-'%'0,/++0*)++,'+,,,-1)1*)*1*.10,(*.)1*1.-,-10**()%..*11.-11-,,,-%./%-,,.+110+*)/,/11.1-,/0+/--+.0%(-(0222+/.-)*0,-,-0*)&.((+)%**%"'')#&"&$.++)%,,/+%)*+)%.0-*+.,(110)0-1.%/11,/0,1120++,*+(-&,%.,/1/)./)1/10-00*.011,-,00,*2.,,12+1..1/*-0-'.,&,++-002/)02-1,,,*2.*)-('00++10)1222 @rCer/1679/2021_58_CCS GAGGACAGCAGGAGTAAGGTGGGAGGCAGGACGGAGCCGGGACACAGTATGGAGAGGGGTGTAGCGAGCCTACAGAGGGCAGACGATCAGGGTGCTGGCGGTGAGAGTCCAGGGAGAGGAGCGGAAACAGAAGAGGAGCAGAAGACAGGGGCACTTGTGGATTGCAGAGCCCCTCAGCCATGTTGGGAGCCAAGCCACACTGGCTACCAGGTCCCCTACACAGTCCCGGGCTTCCCTTGGCTCTGGTGCTTCTGGCCTGGGGCCGGGTGGGCCAGGAGGGGTCAAGAGCCGGTCCTGCTGGAGGGGGAGTGCCTTGTGGTCTGTGAGCCTGGGCGAGCTGCCGCAGGGGGGCCCCGGAGGAGCAGCCTGGGAGAGGCGCCCCCTGGCGAGTGGCATTTGCTGCAGTCCGAAGCCACCACCATGAGCCAGCAGGGGAAACCGGCAATAGGCACCAGTGGGGCCATCTACTTCGACCAGGTCCTGGTTGAATGAGGGCCGGTGGCTTTGACCGGGCTCCGGCTCCTTCGTAGCCCTGTCCGGGGTGTCTACAGCTTCCGGTTCCATGTGGTGAAAGTGTACAACCGCCAAAACTGTCCAGGTGAGCCTGATGCTGAACACGTGGCCTGTCATCTCAGCCTTTTGCCAATGACCCTGATGTGACCCGGGAGGCAGCCACCAGCTCTGTGGCTACTGCCTTGGGACCCCGGAACCGAGTGTCTCTGCGCCTGCGTCGGGGAAATCTACTGGGTGGCTGGAATACTCAAGTTTTCTCTGGCTTCTCATCTATCCCTCTTCTGAGGACCCAAGCCTTTCAAGCACAAGAATCCAGCCCCTGAACGACTTTCTTCTGCCCTCCTTGCCCCAGAAACAGCAGAGGCAGGAGAGAGACCCCCCTCTGGCTGCCCATATCCCACCTCCTTGCATGGGACCCTGTGTGCCAAACACCCAAGTTTTTAAGAAAAGAGTAGAGCTGTGGCATCTCCAGACCTGGTTCTTTCCACCCACCCACCACCAGTTCCCCTCCAGGCCACCTGCTTGCATCTGTTCCTGCCTGCAGCCCTAGAATCAGGGCAAGGTTTGGCAAGAAGGAAGATCTGCACTACTTTGCAGCCTCTGCTCCTCCTGTTCCCACCCCAGCTTCCTGCTCAAATGCTGTTCAGGAACAGGTGGCACAGGTGAGCCTCACAGGCCCCACAGGAGCCCAGATTGGACAAGCCTCAGCAACCCTGCAGGCTCTTTCCTGTGAGGAATGCCAGCATCACAGATCTCAGCCAGCCACCGTCAGAAGCTGAACCAGCACCGTATGGGCTAGGGTGGAAAGCTCAGCCACAGGCAGAAGTGTGGGAAGGCCTGGAGTCTGTAGCTGGTGAGGAAGGAAGGAGGGTGTATTGTCTAGTCTGAACATGGTACACATTCTGCATGTATGGGCAGAGCAGCCAGCAGACAGCAATCCTGGCTGTCCTTCTATGCCAGATCCCAGATAGACTCTGGCCCTTACCTCCCACCTGAGACTAGGTGAGTGTGTTTTGCTCTGGCTGAGAGCAGAGCTGAGAGCAGGTATACAGAGCTGGAGGTGGACCATGGAAACAATCGATAACCATACATCCTCTTGTTTGGCCACCTCCTGAAACTGCTCCACCTTTGAAGTTTGAACGTCGGTCCCTCCACATTCTGACTGCTGCCTCCCTCCTCCCAGCTCTCTCACTGAGTTTATCTTCACTGTACCTGTTCCAGCCTATCTACACCATCTCTCTTTCTCCTGATCTGTGCTGTCTTAATTCTCCTCCTTAGGCCTCCTATTACCTGGGATTCCATGATTCATTCCTTCAGACCCTCTCCTGCCAGTATGCTAAACCCTCCCTCTCTCTTTCTTATCCTGCTGTCCCATTGGCCCAGCCTGGATGAATCTATCAATAAAAACAACTAGAGGAATGGTGGTCAGTGAGACACTATAGAATTCACT + %*%')&'*,)++(&.,-#''*+(),&,+,)*-.,-,'&+)&((%('#++*'(((&&)+$(**)--)(+-&,+--+),,(*)(*(-**-))*&(*'(-()-,*')+),--)---*-*)*&&,(%,.,)-*&&$',$%#((,+-*+)+-*-.*,&(*(,*-+,,(*,-+((-..+)++(%'**,,(+('%'%),),,)+%(*+,(),),+++'),*')*'+&''+)-,*,('*+#,)%(%)+**)+,-*+*+%*-,),$'&()#))-.)-,)()'+,%&)))&,+*%**,*+.,-,+-+),++,-++,&),')(&+')-.(*-&+*---**#,,*--*(,(,*,(+'),)),$'+(%+').+%'+%(+$+,)(,&(,),'(**)#(,$+)),)*%'%,(*%'&('%,+*(,,&*,((,-,,))()-*,),)&&$)(&-*+*),*'*'&"+'&(,(&'&,,*&,)(+(,*(,$*%(()''),*$*$+)#(&()('),&&#.)(('+),'&)-+'))%(*((&+%&()$,**,**,$++*)&,,,$*(++&(''),,)-'-,)'&$,'''+(+&++'+(,)%)(**'*&,,**%+')*-)-(,+*'&$$#++*(''+(&(&$(&-)+%*,-&-(,*,--.+**'#,&#-%',&**+(,*$+','(+(.(*(-++&&((%#&&')-+()(&$'$%&'%'%)#$+$'*)%#%"#%&"%)&)(')&$&'''$#$#**%&)',&%#$,'(&+-(-+-.+(+-)%%$%++','&%&$"%$(&+(&%&#()-)*(%()+'*('$(((+(,&*&%($)(&+'(*-&+-*&%%()&&*$*)((+'&*$$&)'&'(('*$'('+*&'$++%''*)$&&)'$**%(,*)-%'+,,--)+*,,+()(*&%'&*()&*,)&&%($'('),#*$'%%'%$&$)&*+*$%%###&)%*'&*(&(&)),)),,%+'&(*)%'#$%&*('&&)&)$$$*)+((**()('+(&%$('#(('&'&((''+'))--+*($(,%&$$%-.(,--2/.).*&1,)/0+/1,0-,*($*----.(*/.1-0(-.-/-/0++*//%.+'-+,-*20/,)).(+*.-,$,*.2/-,%/)*)*&.,(0,/00++0&&&#*-&.)'.0-'('),,+--+'+-+*(-+-**),&(+,+#(&*%,&)--,)%+()()((''),-(+--(++&)-&,*,&#-)*+&,,+)),)*(#',,)()*(+$%'$%&#,,-*--,)(,*(&-*+,'('))()*,)+-+)'&',-)%*,&+%)$)-,*+*)%*,+)%#%**$#''+(()%,(-+-,-'())+)+(,.++++*&+,),*+),,,,&(%*$++'(#(*-,*,,)+$''&))()+,(*(---)-,.*)$%%((+'''(,)(()-,*-*')(*&+*%((++)%&(,%*((,''$&'(%&'%%%()(,',++**((()(**((*),)'%$*&(,.+*-)**'','#%'(+,--,-(-+'.)-*))#%$'&%$$(%%$&)%$#'*)*)(#$&(#+-('&-&#'-**-)&(*)+,'-,+(,,+($+(,))+-,(*)()*-)()+%,((&((,)&$'#%+*))-))%&,-,+),---)++..-.&+)+)%$*%''-(*(*&(*(,+(***',*)+',$#((,*,++(%&%"#()(&(-%,+(&,-)*(+,+)-,(*)%&((%&++&%((,---*+,(''$&,*,#(%*+*&,'+$'&'&&(()'&&+'--*(+(+(++(--,,)(***&,+))(++*)&,((+%$$-),-(*,,+)(+.+-*%&'(''$''$,,-&,.(+#(&&&)%)+((-))+,-)-.,+*(''(*-,(','&#%,,-)(+,,*)&#$&))&+&'&,-*)+))*$*&))--&+%'*,,.(,)*#'(()')-'--+)*+*())+'#$',*-+-(,*).,,-((-+*,+*')+(--,(*+7$(+'*$&"$% @rCer/1682/25_1759_CCS ATGGGGGGCCGCCGGGATGTGTAGTCCGCAGGAGTCCGGCATGAACTCCTTGAGCGCCAGGATGCTGACGCGGAACCGGAGCCTGGGACCCAGGGCTGGACCGCGGGGTGTGGGGAGGAGCCCGCGCCTCCCGGAGGGGAGAAGCTGCAGCAGAAGCAAGGGAAAAGCCACAGCCCCGTGAAGCGTCGGCGGAAAGCACAGAGACTGTGTGTGGCCTATGAGGGCTCGGACAGTGAGAAAGGTGAGAAGGCTGAGCCCCTCAAAGTGCCAGTCTGGGAGCCCCAGGACTGGCAGCAACAGCTGGTCAACATCCGTGCCATGAGAAGCGAAAAGGACGCACCTGTGGACCATCTGGGGTCGAGCACTGCTATGACTCCAGTGCCCCCCCAAAGGTAGGCAGGGGCCCCATCTGCCCAGGTAACCCCCGCTCTTAGCAAGATACTTGTTTTCTCTCTACCCGGTGGCTCTTGGCTGGCACCTTCCCCTGCAGACAGCACCTTGGGAGGATGTACACCCGGTGCCCCAGAGCACTGGGCAGTGTCGCCTGCATCACTGTAGCCACTCAGCAGGTCAGGATGCTGGTGGCTTAGGGCCTCGTGCTAGAACTTCTGCCCAGTGCAGGCGTGACCTGGGCTTTGCGTGATATCGGGGAGGAAGAGTTCCTTTTGCTTCACGGTCCCAGGGCCTGGAACCCTAGACCAAGCTGAGTTCTAATCCCTATTCTACTATCAGGTGACTTGGATACAGGCCTCTCTGAGCCTCAGTTTGCTTGGCCTCCCGAAGTGCTGGGATGACGGGCGCAAGCTACCGCGCCCGGCCACATACGGTTCTAAGCGCTGAGACAATTCATTTAAGCTTCACATTGCTCCAGTGAGTCGAGTACTATTTTTGTCGTGGTGTTGTAGGTGACCAAACACACCCAAACCAGACCTCCCTACCCCATAGGGGAGGCCGATGCCCCATATGTGGCCCAGGGTAACAAACGAGGGTACGTAGAGGGCGTGAGGGAGCCTGGCCCAGGGAATCACCCAGGACCCGCCACCACCCTGGTCCCTGTCACGGCACAAGCAGGTGCGCAGGTACCAGGTGCTGCTGTCACTGATGCTCTCCAGCCAGACCAAAGACCAGGTGACGGCGGGCGCCATGCAGCGACTGCGGGCGCAGGGCCTGACGGTGGACAGCATCCTGCAGACAGATGATGCCACGCTGGGCAAGCTCATCTACCCCGTCGGTTTCTGGAGGAGCAAGGTGAAATACATCAAGCAGACCAGCACCATCCTGCAGCAGCGCTATGGCGGGGACATCCCAGCCTCCGTGGCCGAGCTGGTGGCGCTGCCGGGCGTTGGGCCCAAGATGGCACACCTGGCTATGGCTGTGGCCTGGGGCACTGTGTCAGGCATTGCAGTGGACACGCACGTGCACAGAATCGCCAACCGGCTGAGGTGGACCAAGAAGGCAACCAAGTCCCCAGAGGAGACCCGCGCCGCCCTGGAGGAGTGGCTGCCCAGGGAGCTGTGGCACGAGATCAAACGGACTCCTGGTGGCTTCGGCCAGCAGACCTGTCTGCCTGTGCGCCCTCGCTGCCAGGCCTGCCTCAACCAAGCCCTGTGCCCGGCTGCCCAGGGTCTCTGATGGCCGAGCAGCTCCCGCGCTCGGTGCTGCTGTCGCCACAGTCTGTGAAGTGGCTTTACGCTTCAGGAAGCCACGCCTGTTGAATAAAGCTTGGACTGTTTG + ;928=:>=3>>57*=60656>;7=7>>@;=6A<'?;??>AC>C>?>>;?@<@B4?=;04;6;689<5?<5>@9;?A<+456=A><58>7&1234<:5=CC8,4?<&>@B:B/32%=;5<2+9<88<08?A-<06<==>=AA:28%12693?>?DD>A:>1E><=@;8CA<8>=FEHCDADC:.EIFI@A><:@7D;;@9C3CBC@D8D>DEGDE:@BEB3CB7<:EHJECC>6D8BEDBDHCEG>@A?><<0BACJ<@HH#DDFBEG;AA6-'?26@IBB==>@=>>G)DC>>EC6C=BFA6/AEGIFBD<6@;>2BB;H+EIHDB>29.97?FFJH@AF>:EG.CB>?ABEHA>8CC;FC7D9>8/2BHF?EGEB;DBD;DFG6@C@D:=16B=7?.F7FE=AAC?>AA??2F@8>.-A@ACBAH?,?;9:ADCBDB9EECF::HCBEEABDH.>DA<;D424AA8J>%CF=IF;CGFKEDAAHE>CE4EACE=7E6@=?CEE=IC@CHBFE+D>;FB>7>5A?CBEEB69D;C=<99@DHI=85:,D1;CBGHCD:B?A@B7FGD;C>6CA9F9C@FE;A=E;C=CCDIBFIDBK;DEHHJKHGACKJ@JG4?H5?4HIBEGHDKKHKJJHJFFAJ8E;EKIHIJ?KKJGJCBD==FIHDCHIHKFIFKKJCDD3BEED9IKIHI@HJG@JIKIH??JJD7HEF$FC88?IHJK;KKJ+KH2@DJH@KHI>KD;DGDCHJB7BCDG2/:9AB>=2=256??AFC>::AC=9=AFCD?EBB>4DD?B4DJGEGDBH:<>B?7B2;DBE@@<=5-B=BEB4@GCA@EF3.FGE@C>8DEGI?AGADCFBI;HFE@DI/JH?HEEBEAB;B4FGA>HDAE9?:A3;A?:=6;?4BEC82:EF.;@@@@FB)?=@3A@>9*<;(59569:<6;83;?E>@E9B=C@D/:38657.9+::5=8<09;418452&0508562552&1,3%..(/)87:9/)50+48893=;537297>865174379916-;7694:=:99.9/3824*/-42)$35<;87%97173011932743-26607763456:66+48787'68165189'3(55.*0-+4.8.577,8292472/3',-51703*78/753798579,-2.1149046/352145,-,2;783&4'0/510519: @rCer/1683/26_1624_CCS ATGGGGGCATTTGTTTGCGATCAGAACCCGAGGTGTGCTTGTGGCTACGGCTGCTAACTGGCTGCGCACAGGGAGCTGTCACCATGCCTCACTTGTACCCAGCCCTTTCTGCTGAGCAGAAGAAGGAATTGTCTGACATTGCCCTCCGGATTGTAGCCCCGGGCAAAGGCATTCTGGCTGCGGATGAGTCTGTAGGCAGCATGGCCAAGCGGCTGAGCCAAATTGGGGTGGAGAACACAGAGGAGAACCGCCGGCTGTACCGCCAGGTCCTGTTCAGTGCTGATGATCGTGTGAAAAAGTGCATTGGAGGTGTTATTTTCTTTCATGAGACCCTCTACCAGAAAGATGATAATGGTGTTCCCTTCGTCCGAACCATCCAGGATAAGGGCATCGTCGTGGGCATCAAGGTTGACAAGGGTGTGGTGCCTCTAGCTGGGACTGATGGAGAAACCACCACTCAAGGACTGGATGGGCCTCTCAGAACGCTGTGCCCAGTATAAGAAGGATGGTGCTGACTTTGCCAAGTGGCGCTGTGTGCTGAAAATCAGTGAGCGCACGCCCTCTGCACTTGCCATTCTGGAGAAATGCCAACGTGCTGGCCCGTTATGCCCAGTATCTGCCAGCAGAATGGCATTGTGCCTATTGTGGAACCTGAAATATTGCCTGATGGAGACCATGACCTCAAACGTTGTCAGTATGTTACAGAGAAGGTCTTGGCTGCTGTGTACAAGGCCCTGAGTGACCATCATGTATACCTGGAGGGGACCCTGCTCAAGCCCAACATGGTGACCCCTGGCCATGCCTGTCCTATCAAGTATACCCCAGAGGAGATTGCCATGGCAACTGTCACTGCCCTGCGTCGCACTGTGCCCCCAGCTGTCCCAGGAGTGACCTTCCTGTCTGGGGGTCAGAGCCGAAGAGGAGGCATCACTCAACCCTCAATGCCATCAACCGCTGCCCCCTTCCCCGGCCCTGGGCGCTTACCTTCTCCTATGGGCGTGCCCTGCAAGCCTCTGCACTCAATGCCTGGCGAGGGCAACGGGACAATGCTGCGGCTGCCACTGAGGAGTTCATCAAGCGGGCTGAGGTAAATGGGCTTGCAGCCCAGGGCAAGTATGAAGGCAGTGGAGAGAAGATGGTGGAGCAGCAGCACAGTCCCTCTACATTGCCAACCATGCCTACTGAGTATCTACTCCATACCAACAGCCCTTGGCCCAGCCATCTGCACCCACTTTTGCTTGTAGTCATGGCCAGGGCCAAATAGCTATGCAGAGCAGAGATGCCTTCACCTGGCACCAACCTGGCTTCCTTTCTCTTCTCCCTCCCCCTCTCTCATTGCTGCACCTGGGACCATAGGATGGGAGGATAGGGAGCCCTCATGACTGAGGGCAGAAGAAATTGCTAGAGGTCAGAGCAGGATGGCTGGGTCTCCCCCTACCTCTGCCAGCTCCCACAATTTTCCCATGATGGGGATAGCTTCTCCTTGGGCTCTCCTTCTTGCTTGCCCTGTCTCCTGGGATCAGAGAGTAGTACAGAAAGCCCTGACTCATGCCTTGAATACATACCATACAGCAAATAAATGGTAGCAAAACATGCTG 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'.2/25655.521*12(#*.-210$265768,/'23750541,1(&%+-7176:90953.5::3-22-,1)38=<3:99/0:3*756:11335?96338+863:90;<<93/;/7038777533;6@.7,1198<5.83<:97:9:-@A:6?8066436<8>C?;>5BA39;$5/2:B7<394608*/46;?*0.+4<@99/3%8'+.555<=>@@4<<);45736;98=6)849/73086,:8/0:#,56649===?)69?9;=>B:;;<:93-4*8;%4<>;;28@C6A8>:9?=097?(41%250<<7B:7&79A975856?;@9ABD9B5,<4=-8=8;*@3128BD;96<1)178;8210>=$6&?3?<33:CBA<47@7:>@EA?>B85@C;8*599?>:9=>5<;B@=;@5E@2=179237<7866031/:8=>1@BD/A@=>D?6B9:3EB'8AAC=9?,A629'.(*%31/,(+14/**3-5)0'.,))/,$0&2:52?1>@=9@86(15C<;A;=@+6;?9+588$;,1344.=7=B8<7;;5;,6=BB>+=;@9;08$4).49?8@18=>6<5:22>A6>>;:&449@269/7B>B?;:6=3BC9?4=3B>5?2A?=EF;>88':=>04?;;??A>@A88B.A<0>8?7E:+:1>B9@A6@1@=;D12676>.68?>D5EFD;@7;6AFF@B?D>5CEE=FB89EFIH67?;EAH8@BDC:6AD3=>9;?EB:7*4846B9=@9;C4?<9@.63>39;69AB@7=/5/37695859?:/>7=/3).-(*)*60;0(18689:70633/,3<::3+2'3203;75;=@>(/<0<6>6AEBCBC@E8>B9:@72838)-/172.+(00*13444,7-36#903:8=?4B97/6,32/28FBB?DAE6956:0?;3+<>:B39:3?>9+@9)1*963366=010-/(+*2:46;-9:,9<'7=<9475-6*8;:?91'44-9.%'&13;=88@?9;>73:6/202/??534-)9+2+%4*'*'$17365=>;651403022+46-25824640)3546777;2;<97>5=890<57'(+.7;9-5*53.3289697<297209;79944:/+201953214859;9:41=9*<797:;:88/0-'/4957385+--2780+0052:589<9<:3:;4><:318==::1/324347665<<706+;6-06/4..3&663'21-0/:1+95,#&+.2).-3*/19.8682.406-00-0,712=9:397410;>8123'<51433,81.0'1701%*',%1824:767/1+,++1407-..)-&-*((-+.31*6341552)3-$.0%2-),***$*- @rCer/1685/1034_86_CCS GGGCATGCCCCCAGGTCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACAGAGCCCACAGCCGGAGAGTCCAGAAGACTACGCACTCAGAGCAAGGGTAGGAGTCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTACCCTCCCTGAGAAATAACCGGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCCCCGAATTACCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGGCTCTTTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCTCCCTAACCTACTGACCCCCTTTTGATTTTAGCGACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTTGGCATCACACCTCCCGAGGACGAGATGAGGAGTAGTCACGTGATGCCAAAAACGCGTCTCTTTTAATCCCACTCTATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGAGGCTGAACGGAAAGTGTACACTGTTCCTGAAATGAAATAAAACAATAAACTTTTAAT + -,+-(%)*//-).2/.($//.*,+//1(/,/-.-01'')-,.1,--*0,0.11,(.-/&1.1/1.)*,'-%0-).(*&*%**&-0,,((*&*)'1.+-,0./,-*,(+,0-1*)-&%&1-+*)&'++#*.)./.0--++&,0.)+'2.11,-*02,-*/&02/11101,,/-,%-20/,.*&$)&+,$(*-$-0+,,+0/+0/'',),&,,+)&--+)&%(&,,$#&+)),+),+&+-(-,,,)'*)'%$)'+*%'($*'&&&()%%%%($#($&'+*'('$*+-.,+-+%(%))+*')*(+,&)&*+*&$&(%,'(&$'&$"$)',+,--))*#**'+)++()(')-',-*$,-*),+(-*-),***$*')+(+--&'--*-$'+-*,)%"+++('-,-+),)+(+$&',()''+('''*(),-+,*(%,)),))'&))()-+*&,+&()%%)$((*$*+,(,*%),,,&(*'#$%*++,-),),(---(,--+)))--+()(('$$**,$&%(*%,+)',)+&*'',')&*%',-*+(,,'&+*+-+'(+,,&'$*$),-)((%+%%#+-*)$""%"%'*#('(+,&(+,#()*$&&(*&++(,',*,--.+)',-+(%&&&$$#%$&&&%$##)&'++%,,-()''&$$&+)&))',,))-%*+(,+'&''##'$#'()'&&$&*&&$'%*+,&+(*+($%%$',2.0/-,*,-')&/.&%.)/%'-,,)/-/(++,)++&0-*-$#$$)-*&)1.31..250+#-41/,26-/62541/1+05/-1.20'..0+(,1++-'*$',4,00*',4+0,-##+.004333/.+0-)/%%/130*1022)0/240'+4205-.-554)3/.*%123-',302+-5310/.$3,0425/.-.21*0//.%(/0*,.)0*0021.#06631--/%10-+3613)/6,1)) @rCer/1686/1935_59_CCS ATGGGCATGGTGCAGCCTCCAGGTACAAAGATCTGAGGCAATGGCGATCCCAGGCCTTGCTGCACCCTGAACACAGCTCAGACCGGTGAGGGGTGATTCAGAGGTGGGATGGGCAGAGAGGGCTGGCCACTCTGCCTCAAGACTTGACCTCAAGTCTTCTGTCTCCTGACCTGGTGTGTCCAGAAGACCATCCTCTTTCTTGCCAGAAGCAAATGCTAAGATGGACTGCACAGGGCCCTGGTACTCCCTAGGACCCATTCAGGATCTCAGCTGGGCAGGGTGCCACCCAACAGGAAGATGTGATCTGAGCAATAGTGTGGCCTTGTTTCTCCACTTCTGGTTGTGGCTGTGTTTACAGGGCTACCTGACTATTTTCACCTCTGACAGGTGTCACTGATTTTCTTTCCCCCATTTAAAAAAGGTCATTTAGTCAAAGACACAGTGCTAGAAGGTTTAAAGGGTGTGATGTGTTGGTCACATCACAACCAGTAAGAAACGCTTTGTAGGTTATCCACATCTTTTGCTGACTGTTTCCATATACAATTCTGGTAACCATATTTTCCAAAGCTAAAATCCAAGGCGTGGGCTGATGGTTTTTGAAATCAGGATTACCCCAGGAGAACCAGGTCCTATTACTAATTTTCCTAATTCTGAGGCTCTGAAGACTTGTCTGAGACACATTCCAGAGACCTTTGTACCAGAACTTGGATGCACAGTCCAGCTTACTACTGACACACACCTGAGTACCCTTTAGGGCGAGGTGCCGCCGCCTGCCTGCCATCGTGTCCCTCAGCATCAGAAGAGTTGAATTCGGCCGGAGACGGGAGCCGGTGTCCATGAGGGAAGAGGGGCCGCGCTTGGTTTCTACGGATTTCGGACTTGCAGTGCGGCTACCTGGCCCTGCCCTGCCTCTCTCTTTCTCATACAGCTTTAAAACTTTACTACTTTTATTTAAAACCGAACTGGATGGGAGAGAAGTAGCTTCCCCTACCCTACAAGTCACACATTCCCGAGAGGGGTGGGGGTGGAGGCAGGAAGTCCGGGGTGGGGTGGGGGGCGAACAGCTTGCTTAAGGCCTCAGGGTCCTGCTTTCTCCAGCCTCTTCTGAAGGGCCTGTGGACAGGCCACAGCGCCTGCTTATTTGGAAACCAGGTGTGTGAGCCGAATGCCTGCGAGGCCACACACTCAGCACAGGAGCCCCCCTGTATCTGGCTGCCCTGAGAGGAGCAAGGGCCACCTCCCATGTGGCTCTAGACACCCCGCGGGCCCATCAGCCCCAGTGTCTGAGCGGGCTCCACCCCGGTGCCGAGTGCTGGGGCCTCTGGGGCTGGTCGGCCTCAGCAGGAAGGAGGCACTACTGAGCAACTATGCATTGTCATTGTCGGGTTTGGGGCTTGCGGTGGTTCCTTGGTGACTGGGAATTGCTTGTGTGCATGTGTTGGGTGCATGCTTCCGGGCCTCAGCTGCCTCAGGCCCGCACAGGCAACCCTTTCCCATCCAAAGCCATTGGTGGAGCTTCTCTGGAATCGTTTGCCAAAAGCCCAAGGCAGAATCCAAGGGTCCAAGACCATTTCCATGGAGCTCATGTTTTTCTTTTCTGTAGGAACTTTTTTTTAACCAGCACCCACCATAATTCTGAAGGCCATGTTTCATCTTCCTGGATCACTACAGTGAAGTATTACAGTTGTACAGTTCCCAGTCTGGCCTTGGCTTGCTCGGATAAAACTTTGTATGTATTTGTATGGCATAGATTCTATATTGTAATGATGTCCTATGCAAAAAGAAAAATTAACGAAATTGTAAATTTTATTGTTTTAACGTGTATGCATGTTTAGTGACGTTTACATTTTGAAATAAAATTTATGATTCATTATTT + KKKK,KKJH>KKKKKK=KKFKKJIKKKKIKJKKKKKK.KKJKK>JKKJKK6KKCK9KAKKKKKHKK9KKKKKKKKKKKK@JJK4K5IFJKKK(KJKKKKKKJKFJKK-KKKK+KKFKKJKK2KHKKJHJKKICKK2DKKKKJIKEKKK@JKK?KI;K4KJKKGKKEKKKKKKKCIIJEKK:KJKIKKK@JKKKKKKKCKKEIK4JKKIKKKKHKKKKKJKKKKAKKKKKKKJKKKKKDDKK@CFKKKJKKKFJKFDKKKCKKKKFKKKKKKFKKHKKKBKKKKK3K@KKKI7KKKK?KKKGKKKKJKKKJKKK(KK$KKK5:8GKBKKJHKKHKKKKKKKK.KKJKIKJKJKJK9KKJJKKIKKJK@FKKJKKHKIKKIKGKKKKKKKK@KKGIKIKIKKKKHKKBGKKHKKKG=KKK=JK*KKKKKK=KJK.KKKKKKKKK(KJKKKHKKKKKKKKKKCKKJKJKKHKKKKKKKKKK9KJK%IJKJIK4JKKKKKCKKKKKKK1KGKKIKK@K;KKJKKKKKIKKKJKKBKKKJKKKKIJKKKKHKKJJK2KK-HKKKDKKK9KKKKJHKKBKJKKFKKJKJKKCKKK=JKK@JKKK5KKKCHKK;KKK&KFBKKKKKKJKKJKKK4DDKK8BKKKJKKKKJGKKKIKJ6KJFKKKK%@KKKK.IJ/FK7KKKKKKKKKHKKK3>AGK,EKKKKK6KKKKKKKIKKKGKKKKK;@HK?KKK+KJKGKKKKDKK;KCKKJKEKKKKEKGKKJKKKKIKKKKKKKKGK/KKJ:KKDKKIKKAKHHK>CHKKKKKKKKBKCKKKKKKKK/KKK8KKKCKJKGKKKKJKKJKJKKJKKJKBKKKJKKKAKEKKKKKKKKKKIKKKKK8KKFKBKKKKJKJKIKKKKKKKKGK<,=)02>.)#4-4$::86.$#$=9176.=*;787&7.+0<0759>9):4-3.12$3<9%)02&-229;269*09456/*$&16&6>278299)85;13/4+.5>?8>91@B;5:?:==?3@3E;<74EEGB@?+?@>?A>1:*?=;7:2B7&52+6;//B,2>D=';@:D'9;:90+)8%#5+92<<9$2:7'11&8:<>=A@=;%3::/)65B:0?A@:>;,#73%.:4%*)7/93)6=7566424;257993&%,':14.030..3.32-/0*1-+2,0,/97202$7110*15,'46;,*88;*==3-*+/354.&$3($'*-&..3+45623-4/1$-,'%'0+5--+.$+$ @rCer/1688/1857_53_CCS ATGGGGAGGTGCGAGTGTGGAGCAGGGACAGGTCTGGGCAGCTCTCGGTGGTTGGCACCGGTTCGCACACCCATTCGAGCGGCAGGACGCACTTGTCTTAGCAGTTCTCGCTGGCCGCGCTAGCTGGTGAGCGTCCCTTCTGTGTGTGGGTCCTAGAGCTCGCGGTCTGGTCTGGTCCCCAGACTGACGCCTGGTCGGTGACCCTCTTGTCTTACAGCGGCTTCTGCGCTCCGGCACTCTGTGCTCATCAGCAAACGCCCTGGCGTCTGTCCTCACCATGCCTAGCCTTTGGGACCGCTTCTCGTCGTCGTCGTCCACCTCGTCTTCGCCCTCGTCCTTGTCCGGAACTCCCACCCCAGATCGGCCGCCGCGCTCAGCCTGGGGGTCGGCGGCCCGAGAGGAGGGGTTTGACCGCTCCACGAGCCTGGAGAGCTCGGACTGCGAGTCCCTGGACAGCAGCAACAGTGGCTTCGGGCCGGAGGAAGACTCGGCTTACCTAGATGGAGTGTCGTTGCCCGACTTCGAGCTGCTCAGTGACCCTGAGGATGAACACCTGTGTGCCAACCTGATGCAGCTGCTGCAGGAGAGCCTGGCCCAGGCGCGTCTGGGCTCGCGGCGCCCTGCGCGCCTGCTGATGCCTGGCCAGCTGGTGAGCCAGGTGGGCAAAGAACTACTACGCCTGGCCTACAGCGAGCCGTGCGGCCTGCGGGGGGCGCTGCTGGACGTCTGCGTGGAGCAGGGCAAGAGCTGCCACAGCGTGGGCCAGCTGGCACTCGACCCCAGCCTGGTGCCCACCTTCCAGCTGACCCTCGTGCTGCGCCTGGACTCACGACTCTGGCCTAAGATCCAGGGGCTGTTTAGCTCCGCCAACTCTCCCTTCCTCCCTGGCTTCAGCCAGTCCCTGACTCTGAGCACTGGCTTTCGAGTCATCAAGAAGAAGCTGTACAGCTCGGAACAGCTGCTCATTGAGGAGTGTTGAACTTCAACCTGCGGGGGCTGACAGTGCCCCCAAGGCAGAGACAGCTGAACTTTTGGGGTGGAGACTAGAGGCAGGAGCTGAGGGACTGATTCCTGTGGTTGGAAAACTGAGGCAGCCACCTAAGGTGGAGGTGGGGGAACAGTGTTTCCCAGGAAGTTCATTGAGTTGTGTGCAGGTGGCTGTGCACTGGGGACACATACCCTCAGTACTGTAGCATGAAACAAAGGCTTAGGGGCCAACAAGGCTTCCAGCTGGATGTGTGTGTAGCATGTACCTTATTATTTTTGTTACTGACAGTTAACAGTGGTGTGACAGCCAGAGAGCAGCTGGGCTGCTCAGGCCTCGGCCTGGCCCAGGGTGAAAGGGCACGTGCTCCTCAGAGCAGCCAGAGGGAGGGGGAGGTCGTGGAGGTGGTTTGTGTATCTTACTGGTCTGAAGGGACCAAGTGTGTTGTTTGTTTTGTATCTTTTGTCTTTCTGATCGGAGCATCACTACTGACCTGTTGTAGGCAGCTATCTTACAGACGCATGAATGTAAGAGTAGGAAGGGGTGGGTGTCAGGGATCACTTGGGATCTTTGACACTTGAAAAAATACACCTGGGAGCTGCATTCAACCCTTCCCCCACCGTGTGCTGTGGAGTTGAGCTGGGAGGGAGGGGCCGAGAGGGTGGGGGCTGGAACCCCTCCCTGGGAGGAATGCCATCCGGGTCTTCCATCTAGAACTGTTTACATGAAGATAAGATACTCACTGTTCATGAATACACTTGATGTTCAAGTATTAAGACCTATGCAATATTTTTTACTTTTCTAATAAACATGTTTGTT + KKKKK3JKEKKKIIKKKKKJKKKKKKGKKKKEKKKKKFKKKKJJKJKHKKKKAKHJDK=KKKKKKJKKKKKKJKGJI?KKKGKKJCKKKKJKH@K9KKCJKKFJKHKKIKKKK0KIKKKKKJKKKGIJJKKKKKKKAKDKKKKIHJKHKGKKGKJKKKKJKKKKJIKKKKKK?KKKKKKJKKKKKJKKKKKKKKJKKKKJKKKFK@KKKJKKKJKKKJKHKKIKKKKKKKKJKKIIKKJKKKKIHKKKKKKKKK3KKKKHKKJKEIKJKKKJKKGKKKGDKKKKKKAJKKJIJIJDJK2KFKIKIKKKJ;JKDJKKKKKKJIKKKKKKKKKKKKKKKKKKIKKJKKKKKKKKDKKKKKKJKGKKKKKKKKKKKKKJKK>KHKGKKGKCKKKHKKKIKEKKJKKJKKKKIKKKKKKKFJKKIKKKKKKKKKKKKKKKKKKJJKKHKKJKKKKKKJKKKKKJHKJJKKKKKJKKKKKK5KKKKKKKKKKIKKJKKKJKJKK=KKHKKKKKKKKKIKKKKKKKKKKK6KKKKKKKKKKKJKKJKKKJKKKJKJJJDKJJJKIKKKKKKKJKKKIKKFKKKKKHKKKJJKHKHKKKKKKKKKKKKKKKKGKDIKJKKKKK*KKJJJIKKKKJKIKKKKKKKGAKKKKK.KKKKKKKKKKKJKKKKKKKK@K;KKKKKKKKKKKGKKKKHJKKKKKJIHKK9KKKKGKKKKIGKKKKBKKKJKKKKKKKGKKKJJKKKKKKKKKKKIKKKKKKJGKEJKKK5JHKKK9KKKKKKKKIKCKKKJKKJKKKIKKK7KKJKKJKKKKJKKKKK@KJKKKKKKHKKKKKKKKKKKKKKKJKKJKKDKKIKKHIKKKKKKKKJDKK;K:KKKKKKKKKJKKKKKKKKKKKCJKJKKJKK>KKKKKKKKH&KKKJKJKKKKKKK'K@K>KKKKKKKKKJJKKDKKKK:DKK.IKJKKKJKIKKKGKKKEKKKJKKKK=DBAD5DKKKK(KKKKKKKKIKKIKKFKKGKKKKKKKKKKIKKKKKKKKHKK8KKKKEJKKKKKKKKKDKKKKHKKKJKKKK9KKKKK@KKKKKKKJCKKKKKKKIKKKKKK>JJKIKJJKJKKKKKKJKKIIKJKKKKJIKKKDHKKKKKKKKJKAK;KKK@KKKHIKKKGKKIKKKKKKIKKKKKCKKK>KKKKKKEKKI @rCer/1689/0_1668_CCS CGTAATCTTAGCAAGATGGCGGCTCCCTGGGTGTCCCTGCGCCTGGTGGCCCCCATGTGGAATGGGACCAGGGCATCCATCGCCTGGGTGGGGCAGTGGTCCAGAGGGCAATCAGAAGAAGGAAAGGAAGATGCTCCAGTTCCTCAACAAACATTTCTACGATGTGGAGGCTCTGAGGGTTACTTGCTCCAAAGGGAGATGTCCAAGGTGCATCTGAAAAATCGATCCTTCACCTGGCTGGAGGAGCAACATGGTCCATACAGTGCAGGTGCCTTTTTCATCCTGAAGCAAGGAGGCGCAGTCAAGTTTCGAGACAAGGAGTGGATCAGGCCAGATAAGTATGGCCATTTCTCTCCAGAGTTCTGGAATTTCCGGGAAGTGCCTGTCGAAGCTGTGGATGCCAGTGACTGTGAAATCAACTACGAGGGCCTGGACAACCTCCTCCTCCTGAAGGAGCTCCAGTCCTTGTCGCTGCAGCGCTGCCCCACGTGGACGACTGGTGTCTCAGCCGCCTCTACCCACTGGCCGACTCGTTGCAGGAGCTCTCGCTGGCCGGTTGTCCCGCGTCTCCGAACGGGCCTTGCCTGCCTCCACCACCTCCAGAACCTCCGCAGGCTGGACATCTCGGACCTCCCTGCCGTGTCCAACCCAGGCCTCACTCAGATCTTAGTGGAGGAGATGCTGCCCAATTGCCAGGTTGTGGGGTCGACTGGGCGAGGGCCTGAAGTTGGGGCTGGAGGAGCAGCCTCAGGACACAGCCAGCCCTGTCCCTGCCTAGCCTTCAGCCCTGTCCCCACTCGAGTGGCTTCTCAGCGGGCTGCATGGAATGTCTGGTAGCTCGCCACACTTCTGGCTTCCATTTGTCTTCACTCAACATGGGGGTGGGGAATGGTGCTGGCCAATCACAGGGAGAGAGCATGAAGTCCCAGTATTTATTCCTGGCTGCCCTTGGCTAAAGGTCACAGCTCCTGTCACCCTCAGACAGCCCTTTCCATGCCCCTCTTCAGGCCTGGGAGGTAAAGTCTCAGGCTGTCAGTAGCTGCAGAGAGCCACACTCACCTTGTCAAGAGACTCTTCTCAAACTGTCCTTATGTGAGTGCACTGCCATTTCTTGCAGGGCCCTGACTGACACAGGAGCTGCTACTGACACTTTACAGGATGGTTCTCCCCGTACAGGGCCTCTCTGCTCACTACAGGACGTGCAGCATCCTTTGCCCCACTCACTAAAGGCCAGCACACCCAGGCCCATGGTATTGCTGGTTATGGATTTATTGACTTTATATTCCAAATTCAGCTTTTTTGGTCTGCGTTTCTGTAGAAAGGGATAAGCTTTGTCAGTAGAGGGCACCAAACAGGCATTACAGGAGGAAAGGCGCCTCCTTCCTGGTTCCTGTTGGTTGTGCTTCCGCCTCTGGACCCGCGGTGCGTGTGGCTTCCCCAGCACCCAGCTCCTGAAGCACCAGGCGGTCAGCAGCTGCCTTGGCACCCTCCAGCCCCAGAAGTTGCGTAGGAGACACAGCACCTCCACTGAGGCACCTCTCTGGGAATAACATTCCCCAGCACCCAGATGGATTTCCAGTCAATTCAGCAGCATTTCACCAGTGAAGCCCTCATTCCAGTTCACTGTTAAAGCCAGTAATTCTCTATATTAAACTTTCCCTGTTCAAG + KKKKKKKJKKKKDKKKK,KG.KEKKKDKKJHKKBFHFK*KKKKJKCKBK?KK;KKI?KG$KKBGJ2JKKKKIKK*KKJ4JFKFJKIDKK:KIKK7KKKHKKKKIGKKGK.@EKKFKHKJKKJJJIKKHKK3JKK0KH4KKICEKKJGKKKHDIJ7JJKKJKKKKK7KK>KKKFKIKK=KCKK%KKKKKKIJIKJKHKJKHFKKKK@KKKKKKKKKIKKKKKHKKBKKK8KKHKJKJJKJHK?KKHKKKIKIK.KK2KKKKKKJK6KK?KKGKKKKKKJK9KKJI?KKJFKKKFKIJKKKJKIHKKKKJK%KKKIKKKEKK:JKKKIKKKKGKIKKBKK;KKKFDKKJDKKKKK,KK@KKKKEKIKKCKKJ-KJIIKKIKK5K7(JK@KK?KKKJKKJK1KKKGKKKKFKKKKKKHKKKKJK>JKKJKFKKI%KKEKG+KKKJ(KKKKIKKKJKJHKKKGJ0KKKGDKKKKKKHKKFKJKKKKK7KKKJJKKKBKIKIKKKK@KKKKHKKKIKJKKKIKKKJKJJKCKK;KKJKKDKKKKKJJKKJK&KKKKJ2KKKJKFHKJKKK>KEKHKKKKKJ)KKI*FKKKJEGKIKKJAKKIKKKHKKKJKBKKJKKJJ5KKKKKKKKGKK)IIEKKKKKK;KJKGKJ)KKEKKJKJFC7KK;KKKKKKK+KKHIHJKKK;K@KI(KJ5/7JDKKJK>IKJ,KIJJJ:FKJKKKKKKJKKJKGDKI@KKKKJ=KEKKKD;KIKDHBF1DKKHJ*KIKKHKHKKKKKJKKKKKKJGIJI,KKKKKKHJKKKBKH,KKJKKKKKDJJHJ,FFKKKKHEIJKKGHGKFKKGI>%KKK;KHKCF1KKK1FKBKKK>KKKKJJKI9KKIKGK@KKAD;KKKHKJKIGKKBKGK7KKJKKKKKKFKKIH+KIK5K?K6KJKEKKE%KKKKKKKBAKKKKKK>KKEKKKJKKJK-KK+KKKKKK;KKK/HJKJKKAKKIKIEKJ>HK6KKKKJKI/HI?KJH9DJJIFJHKHIKGGKKK;JKHK0KKKJKKGEFKJJ?KKFBKBDH*KKKI4KJKJKKIJCHA4A8D9CHBAJHK)?4KEG*EAJ=JAAKGCGKI?HJ1GHJEIKGKG2HH7KJHKJKIJB@KK5J@KK@IJIE.IEIKJKF@C:C=KJIEIHDKFAIE@@CJEF.@JKDDKIK:KH1KKI9>B2GJHJGCJFCKIKI?HGHJAKJB9DK9JAJIEJHKKKJKCKIKKKJDI5-C1?GG@K>IIB>EAEKGKJKK=IKFH'8=GHKBK5KJGIHGIJICKFJKHDJCG>IHH=D>8KBJKDJIIIH@I@CFD;EG?HGD@JIDJKDIJKEGEHGEIAHCIJH>7I,KG5JHJJH4CJAJ7I>JEF8F>E@EI=IE?0JGG9HIFDCJ.GEJDIGJG?HFGIIHBJ8KKKKJHHH-?2KDGD>*AJECD2EJ??8@IFFKJJKAKKKC6KIJI@HEIIEHG5E9EJKI0IFKJHK>JIJ@D@GF4FKIHCE0GJDIFCGIIK0KJAKIBKKFF)KI1K?GKECHJ;9@KJFJI9JGIG?JBHEJDI/@HEIJ@JJEIJHDGKKKI7KJJJHAHI6KKDAK=K4E7FIKD)JKK;KKEK+JC6K>KJHBBFIFCGGHFJIJIKKHKK=KKF-FDIJKEK4KKIIKJJKEJGK6KJAKH=J7JFKI@EJKGK,KI;AJHEKKIKJHGKJKIAAEFK6K)IKDEJJ8GJKKKKFA9JEKKKKJJKJI=KKIHKKJKJKCIIKGJ0<@BK:KHHHKJ7IJKK=BJGKCJBIH4<<=02273:;;B39A1%780;D2;8>>:B?E@D>>A=B?@7:;3*:A>8E?7@@<>8=4;;95@<8B>66=?9EA;@0>=>1137'>B@6-BA797(9'>>8;>?1=;1$'2:=9=&5=EA@3;?;5352/>8A8<9>9?852=B>:(?3>:+9:4=)(*969@596(621?76:>779=37<5:5:C=@9:809?3@4254885/*3;6:5?<2:35'9=5;<9&37>;A>;<=0:;3>289,8&><887?8<.893A7:.7=96+40778;==.<97)9$8>;?9<87;5:;5:?7?6CA@:?68;>;=<:<57:<8+9/;0106439-A<98@898%2>:.9?;;7?8695:,:91@C@BA4;?>B3@<:=?=7:;9'826;@6A67:&5/9>7B<33245/;994986:4&94/1>6/9?;><2A;=>;=9:<<50::;?0,=:2<+89>108<.8:?5=.5:>;?0:>6B;9:8/?<:?8449:*:,27@>;;=5@:<6>?>A;:,><1<57C??:451,:7:7A7%>0=>:>C:=?;9<<4;-2.81>2@;0@<>5A975%=9<9-5?<--39&?<:<305&49<<:8:22=8<8.90<;;+=8@88940$9(60879>6.<:,4->CB9,4<:7A3.?A6:78.8;;=,?7398:*?<13+13.0,+9;$9A49:(B=@;E5:-89;2,+7:=?C?5;,;7@CE>:>C?<*B93;C@?C4B=9:DF=>99257/33?77@A297?@?;>;=89=A<4>@E>4?17E???=6C=@=<=56C)CEE6?2;?2E8B@BA1@>?:,<>>&?7@B@=A;6546=?7A>2>=<6BE?8=F>195=6:8+<<.?>688>/G>>0==;D:<+/1?/=57:<:?0=880389;06371-(5/?:@:=/:2?6;81;;>20=179.,50739<539:@><78/=:?<=:73$44448.//00B@A?B4<388'B4>6<=;>9B;9><59:7:6@:)1=1(+<:>;846>0/><6>946772,6-299C;D=/>9E;C??:<=C@C>;;;<*<=A5C?<:+/24A61,7A7:8>;8=<:.4,,6:=25<2:68?;6333430*641183=9B366876$=;;;8@;64&75?5::/92<,45:446694+56236)7=(<9:8&6971;5:(5*;582-&5238999@:;.9;<5>723>028558@6;3*56:+=58478?850(05-(-:(43:34<:88.;2018&)5/96?<5>@<=44<;1<09=;:<47776868:<25+90,;46,/31-,41:31<422' @rCer/1693/1983_57_CCS ATGGGGCTTCGGGCCCCGCCTGGGCCTCCGCTTCTTGTCAGCCGCCGCACCCAGGCCGTGCCCGCCCCAACCAGCAGCCCGAGGTCTTCTGCAACAAGATCTTCATAAACAATGAATGGCACAATGCCGTCAGCAGGAAAACATTCCCCACAGTCAATCCGTCCACTGGAGAGGTCATCTGCCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCAGTGAAGGCGCCCGGCCGCCTTCCAGCTGGGCTCACCTTGGCGTCGCATGGACGCGTCACACAGGGCCGGCTGCTGAACCGGCTGGCTGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCCTTGGAGACTCTGGACAATGGCAAACCCTATGTCACCTCCTACCTGGTGGATTTGGACATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATTCCCATTGACGGAGACTTCTTCAGCTACACCCGCCATGAACCTGTGGGGGTGTGCGGCAGATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCGACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACTGCCCTCTATGTGGCCAACCTGATCAAGGAGGCCGGCTTTCCCCTGGTGTGGTCAACATTGTTCCTGGATTTGGCCCCACAGCCGGGGCTGCCATCGCCTCCATGAGGATGTGGACAAAGTGGCATTCACAGGCTCCACCGAGACTGGCCGCCTCATCCAGGTTGCTGCCGGGAGCAGCAATCTCAAGAGAGTGACCTTGGAGCTGGGGGAAAGAGCCCCAACATCATCATGTCAGATGCCGACATGGACTGGGCCGTGGAGCAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAATGCTGCTGTGCTGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGACGAGTTTGTGGAGCGGAGCGTTGCCCGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGACAGCAAGACGAGCAGGGCCGCAGGTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACTGGGAAACAAGAGGGGCGAAGCTGCTGTGTGGTGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACCGTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTGATGCAGATCCTGAAGTTCAAGACCATAGAGGAAGTTGTTGGGAGAGCCAACAATTCCACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAGGCCCTCCAGGCGGGCACCGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCCTTTGGCGGCTACAAGATGTCGGGCAGTGGCCGGGAGCTGGGCGAGTACGGCCTGCAGGCATACACTGAAGTGAAAACTATCACAGTCAAAGTGCCTCAGAAGAACTCATAAGAACCATGTGGGCTTTCTCCTCAGCCATTGATGGAAAGTTCAGCAAGATCAGCGACAAAACCAAGAAAAATGATCCTTGCGTGCTGAATATCTGAAAAGAGAAATTCTTCCTACAAAATCTCTTGGGTCAAGAAAGTTCTAGAATTTGAATTGATAAACATGGTGGTTGGCTGAGGTAAGAGTCTATGAGAAACCTTTAAATGACAACAATACTGCTAGCTTTCAGGGTGCATTTTTAAAAAATAGATTCAAATGTCTTATCCTCTCTCTGAAACGCCTCCTGTAACTTGAGTTTATAGGGGAAGAAAAAGCCATTGTTTACAATTATATCAGCATCAAGGCAACTGCTACACCCTGCTTTGTATTCTGGGCTAAGATTCATTAAAAACAAGCTGCTCT + JCKKK&DK>KKK2JKK+DH4JKK*J*HKIKHK@5KGJJKJKKKJKKE&9BK@AK?KDGHGK?,@KKK/A:F9JEHJGGK(KFK8DEIEKKJIKIKK9JJJBJBJJ=KJ>JI5JKKJKKGEDIKHJKIAKKKKGJKK;KHK*KJKGIKI7JKKJKKK=KKHIHKEIBJJ,KEK7DK6JKFJKK9KCHB:GKGIKCJDKKAKI7-AK=K.F2F?:FFK.KIJJJK3@CJKJK>KKIK0I:KJ6EEK)KHJJ4JK*JKIKKKKEIJKGJAIC@KKGKJJKJKKBHKC?JKKHK5IKJKKKK>HHKHHK%JHIJKJEHCK=JBK9KFDK8HK-KGEK3GJKKJKH>IJIGKIKKIEJKK:KK-9JKGKHK@KKKKKKKKKIIJDK.I9JJII:JK4K>JJFJCJKJJH1IHIK@E,II?J>KKI@JJIJG;FK.K8I4D.CFJKHK8KJKKKBHIFK/JHKEGJHE=JDK@HKIJKKBKEJKK2FHCIK9KKK(@KIKFKGFK?2:K$IKIJIAAECHI9JEKK:JHK?IKJ=HJJCJIKKKF?KDKEIDJIK?D/AH'IDJHKEJKJKGJJDHK8KK8BJEHJHHDK=FKJ,JICFJGIKKDKCK>41E>KKKI&HJAIIBDKK6K<2@FFC@KKJHAIDHIAJK>HGEIIKDHIJKJ.I>KGK>IKH>KDGK%JKJEFHKK&JKK+DKCJK=E8EKK5K8KCFJKJKKDKJIAKKICFKK/K7JK;KIGKKJGHI3@K>DJIHKIDCGKKK@JKKDKKKHDHJKI?IKIK@JKK?KK;K>IJIKKJ>KJGFKEKKKKHK?EJH%KK:KKIKKJK=IG*JJKKKKK.IHIGIJ=GKIKKIIK>DCJJHKJ3G?KKKFIKK=JHK7IJJIGKJKBJGJKKKIKKIKK$HIKGHIFFFAD:9;G'5GHK*G:K?JGFEKDCIKJJHIAFAKFI@IGDKJKIGE69K@GGCFKJK=GIJ:HFHEFK6K?JJ:IK>KI7DHIJK:A;?52I:G;HEHFHJJD(JCKEJGAGJKIIJG7KHJAIHK9KGJKK6KKGKK5K3K@HFKJJKIJKEKK-EKHKK4GK5GKBIJK+BCKHHCG8D@6HIKKJJJJEIIGAFKJIEAFJGK-J3KK3HFBKII7JIKHBIHKHK?IJJJH@IGFHFH=GJKBF:DGCKKGJ>GE7>EKK-IJ@DI-GH@??JFJK>CKBC:CJEDKK1BF=0A4I#@HK:KEHKJHIDE5KKBDHFKKK:IFA;K>KCFBC==GD6I=FGFJJKKKIDHD=DI2F>DK7I7ECHCJJ,:EDDG8HH(HJG2=IK=JJ=ED@JI-DI0GKDH+EJKKK;A;0K3>K(82?44E97I)7IG40B?JII?HH:KK*A7EG%DKCIAAJJ=;K)HJ?8CFA>JJJK+KGKK-AGE:EKJG*6HFJC+FDCGI7IIKD=FHFKCGDF3GHEC:7>GKKFHHK7GF6BBAKHBK?BI9B='GGCHKH*E7F==E?GHKJJDFDKJJCIKJGDGDEIHIKI,DCJHI7;IEKB;DJJAKEK9D??1HJIJ @rCer/1694/25_2175_CCS ATGGGGGAGACCATCCAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + HF'KJ@19JJJKDC?F)EDA=CGGA@A>?:ACCFKJGFEG>KF1HFKJJ?KKJHGCII-JG;KKHDGDBFHJACFIKJ>>KIB>=KIHHCKFKIKJ@H@IJAJG9E?7FJJFHGE:HJJEK>GKI@ECBHE,JJKH7CJHHFBIJ'GF6KKFIHJDHHHJJHAKIJHDGKJJD@EBA'-'&&&&%47H9HJFAHAJKI5IDK*FGIGDF2HADEJD:JKB/JGKK9BGJJKBDIDJBFEHGHH;HEDFKIDA&:JDD0GHI6KJKDCKHF8@D>IKKJIC9KC6=JJDJJBK=?HDC=HIIH@H:DFG@KJ2IBEKIHAK8K4IFED,IAKKADGBIJ=IJHFJKJID>ICJF*KJHH>HBECIBHKEHJKIH7DC:$JFJDHHAK@IKGJBGCHAD,IIJCKEIJ>KHDD+IJCAK1;KKFKGKGJHKKICKKKHHHIKGIKDHJHA;AF6BJ9EKJJI9KKKEKJ,JCCAHCJIGE:FJHICFEIKI@EHHJJJIJBGKJHF3IKKB<5DJ:BKKEHDG=FJGK@G?CJI7HFHJHDBDF;5KIDIH?KJF@KDGEIGEGJKEGBCHJFJBIJIJJJKI9F:AE>GGJKBICG?(KGJK>JIDJFIFGFII,JJKG@5G%JJJICKGIKJHK>=F>GIHH=>B?AII8KCBEGJKG@KGKHHJFEJDHJKI?I*KIA=K1FKJIKJGKHGKIIJ=:JKHD4GIF@JHIIGKIIDIGIIHKH8DC=2EIDDCHDKH3GHKC1JJDKJIKHFDEJIHJHFGKJJD4EJAG?HAIGBJEKJJGDKG8@CG>K@@JIIJIJHJFHF7B?ADI6CGHCB8I;AFH?@DDGC;CJH?J@E>GE:CFFHIH<H=@F@;GDB@F==AIIG=H9HFF+BBJHD?CCB=BEFFEFHIB1BEF?G<:EEJFEDI7JGIHF;I67;GHB?F=HECEDDIGGIGEB>FDG:A?E5IDJB>EDGADHEGHIEEIHHICI'?@?B=5/?:@DFC)DDC-C:EEGFIEI@IIEGJ0FEFFI6HEEEIGFA=BAIIFHEC>FJ+E0F;E:FEEGFBAIIFIDDH5JEI@EA'DD;&AECD9ABBKH*HGGGJFCJIEHFIIJJAIGE:F;I,D/IJJIIIGJFHKKHJGEI:KJDJJIK@K>KIDKBIGIAKHHFGGD8KFH;HAJCCCDB@ABFB?9B*/><:>@CIJHIJBIKHKIJHF?JKKBJGI@JKK>GI3IJJJJFKBHIJHD5JECKKKKIIB'DGFGHI?@EKBIHHDJHC>EIJCJJJGJKJKGEA>KHGAKGKIDH:KBFEKKFIJJ?;EFKG=8AJK2IKKGJJFDFKKKKK/KKKFKB3KJK&HKKBKKKI?EKIKKKJHKHKKIKKJKKKBKGJKBKKGKJJIKJKJBKKJKKKKKKKKKKJKKEIGHEIHIJ@JKKJJJJKKJKKKJAFKK3FKEJDKHIFIKIKFJAEGJJJKAJIFHIKJKKFKFJKHHGIIJHKDKEKKCKKKKAKKIKKKKDKKKKKKKKKKGKJKKHKCKJKGKKKKJIJKKIKGKFKKKI:JIK>KKGJKJICJKJKKBKKKKKKKIKJFIKJJHKIAGKKKHKK:KKKKGKFKKKKGKKIKJJJCIKH=IAGKKKKKIJBF>KEKKFJFKFHIKKKHK@JIKKKJIJKGIIFKKHIBKKFJKKAGJKKKKJIKJCEIKKKKIBBKKKKJFKJK>KIHKJK@EKK=KIKCKKKKKIKKKFKKGKKKKIKGEFKKJKKJEKFKKKJIKKJKGIKJKGKKKKEK9KFKKGKJKKK/KKHKK6KKJJKGKKKJHJ/EHJJIJKJK;KFKJKJKKK2IKKHHKHKFFJE?JHDFHGJKJBF:KKHJJKGIKDKHDIBGGKKKJKJKKBKBKIKHKDKKKIIJKGIKIIJHEKJKKHKKKGJKJADEJJKJJKJKBKJKKKKKIHJKHKEKKKIFHKJKKJJJJKGKKKKKDCGKK.GJJKJKJKEKKKKCJKBKK@JKHKKIKKK@CK(KKKKKKJKKJJAK@KKIKK2JKKBJKKJKKJHJJK->JEKKAKKHKHJKKJKKJKKKKAJK5KKJKKKK%GKKHKF@KEKKKKJKKKKKKGKKIKKKFKKKKKIJHKKKKKHHKKKKKKKKKKJ4GKKKK@KKKKKKFJKKKJ)JHJJICKKJKKHKIKJKKKAKKJKKKKKKKKKK$KKGKKKKKKJF@K'KKK.KKK@KK@GKCKK>KKKKKKKCJJKKKJKKJKIKJIK:KK2KBJFKKKKKK$KKKJKJKHKEKKJKK1KKKKDKKKK;KKKK5KHKKKEKKKKKJKKKKHKJJKJKK>KKKKHIGKDHK@FEJKGG?KKKIJKKKKKHK6IIKKKKKK4KKCJIDKK=KK?KKKKKKK8KKKFKKJJKKGJKIKKGKHKJKKKKKEDB<.4HEKKFKGKKKKKJKKKKK @rCer/1698/25_1900_CCS ATGGGGGGCGCTCCGGTGACAGTCTGCGGAAAGCCACGTTTGTGATTTCGGAGAGCGCAGAGCGGGACGGCGGCGCTCTTGCTTGGTCATCTGGGCCAGGTGACGAAGAAACAGTTTCCCGGTGAAGCAGCCCTCACTCATAGTCAGCGCACACCCCTAGGGCCTAAAGATGCTGAGGTCCGTATGGAATTTTCTGAAACGCCACAAAAGAAATGCATCTTCCTGGGCACGGTCCTTGGAGGAGTATATATTCTGGGGAAATATGGGCAGAGAAAATCAGAGAAATACAGGAAAGGGAGGCTGCAGAATACATTGCCCAAGCGCGACGACAATATCATTTTGAAAGTAACCAGAGGACTTGCAATATGACAGTGCTGTCCATGCTTCCAACACTGAGAGAGGCCTTAATGCAGCAACTGAATTCCGAGAGTCTCACAGCTCTGCTAAAAAACAGGCCTTCAACAAGCTAGAAATATGGGAGGATCTGAAGATAATAAGTTTCACAAGAAGTATCGTGGCTGTATACAGTACTTGTATGCTGGTTGTTCTTTTGCGGGTCCAGTTAAACATAATTGGTGGATATATTTACCTGGATAATGCAGCAGTTGGCAAAAATGGCACTACAATTCTTGCTCCCCCAGATGTCCAACAGCAATATTTATCAAGTATTCAACACCTCCTTGGAGATGGCCTGACAGAATTGATCACTGTCATTAAACAAGCTGTGCAGAAGATTTTAGGAAGTGTTTCTCTTAAACATTCTTTGTCCCTTTTGGACTGGAGCAAAAACTAAAAGAAATCAGAAATCTCGTTGAGCAGCATAAGTCTTCTTCTTGGATTAATAAAGATGGATCCAAATCTTTATTATGCATTATATGATGCCAGATGAAGAAACTCCATTAGCAGTGCAGGCCTGTGGACTTTCTCCTCGAGACATTACCACTATTAAACTTCTCAATGAAACTAGAGACATGTTGGAAAGATTTCCACCACATCATTTCATGAAGCTCTGGAGAAGGTCATCGGTGATCTTTTGCCATATCATTGTATAAATGAATGAATTACAATGCATCTGTAATGTTCATCTTGCTTGACCTTTCTCTGATACTTGACACTGCCTTTCTTGAAATTCTTTGCTCACATGACTTTCATGACAGTATAATCTGTATTTTTCTCCTACCTCTCAGATCATTTCTTAGATTCTTCTATCTCTGTCTTTCCTTTAAATATCAGTGTTTCCAACCTGGTGCAGTGACTCATGCCTGTAATCCCAGCACTTTGGGTGGCCAAGGTGGGTAGATTGCTTGGGCCTGGGAGTTCAAGACCAGCCTGGGTAACATGGCAGAAACCCATCTTAGACAAAAGAAAAAAAATTAGCCAGGCACGGTGGTGCACACGTGTGGTTCCAGTTAACTCGGGAGGCTGAGGTAGAAGGATCACCTGAGCTCTGGCAGGTTGAGGCTATGGTGAGCCGTAATTGTGCCACTGTACTCCAGCCTGGGCAACAGAGTAAGATCCTGTCTCAAACAAACAAAACAAAAAAAGCCATCAGTGTTTCCCAGGTATTTGTTCTTACTTCATTGGCAACTGCCTCCCAGGCAATGATTTATACTCCCATTACTTTACTATGCTAGCAGTTATAGGCAAATGTATTGCCCTAGTCCTCCACCCTCAGGAGCTTGTTTGGATTGAAATTTCTACATTTCATAGATAGAAATAATTTGTTCATTCAGTTAATTCATTTATTTCATTGAATTATTCATTAACTATGTATTGGCTGTCTGTGGTATATTAGGTACTATTCTAAATGCTAGGTCTTCATCCCTATTGGAATTTGTATGTTAGTGGGAGAGAAAAATAATAAACTAATAAATC + 33*353235:95+5267/7:5::997:6:796717776-332575(50.&+,5/758:48675'7766-:96:585461:643;.478403539;4;6069218:394&45579*77(-757786:63.5(8313567476972.3746335*+15527,4739./53463346675963879:8.6-9+150185-3/-30/1/(281-.3986221.*9463066647.:4381717659894.3635.257234807144&$04353%1019:79310-&160//7)4+81'84*,1063/16,22023794&6/.768875087::/957::6.765417667*83755//7125842,366886544:69685/62&-85789.9976589:4::797953296:8288697:52609.763636537854776/61878577;9;78-8)22:)#0224/379:428595+6321812.3833+.0*/304.*331.113*1:6/563:715.17-/0*3.).3.,312'00+557174795&0-.-.$.20150/'/*235868;16.24/7/9456358.297-:64/5758584571653+%,3334-71./33982488/4333/53495639555:/268280935.1599:8:/65774093:27*29,86;:46+6;2:99.50/-4-6399:27562253817711666247689.+448-885-2843(3.)56056-6.8846159.4495,64.87549/5*674/2)767566.:::5,148657'62*54+8185.16./%+)(7537292083.517545(2..35.0/3455,737658368/08478&&'.1/0291646963/38898+94.0,36*5238.55,395;'4664126689978.4278840+#/124:3835/5&2,/155951022.-6.98/9774,4/,3+2&20313+4+//.//0,3.6,/725/7/54-885368/395878135-68:764'2588/713358:641/*(334965,,()0/33616853-0.759:77559332$,455.611*6131.+'675230.8738649(,1.2*0'-0157588+7547958214738+76573.-54/14*/3/4::/1/8492$0/581/69999:763/,096679643.711989:88-73635*5408-95/367620981606454895600401:56685952455-89763:,&4797296.26899:6:492:09819:03883;9:297:66:6)986906688:33;585779699/3/4.+7598/63'75167197834.4/14$98679684525988/558.244233657352857.,088936:1;03227.94/694238164155968559:376945667786982559:848275.5945230;66:956:79&3,52645699;9768814:79;7442672106:308336572995.672+9897&/378821085384010(163627426.%125/686:<=:581+<9?;7956.186*;;46:64=8<4/<52;9810>?376==9==<65<9456<:;4;6<8=83:90:;5==4;:<.846:908:::98%649:=8?<9;697,9:<=5083(8:2:83170.2>9:66=<<)697;=<897;?;9==>=5=9:3;4<9:838??<7;=<97=<:8773+639/:4=897499/-56:;=<8:<<;;<25796;84>?1;;@5=8:7<8&?@?:=;A18065/92=A?<316+4969.;3@==@>><;=(?A<>>*:;@0*596'=;:=9<=@)@?@A?A-63&@?9A;C?5;:7AB;<1:7>AA=-A?9A@9:@:@@=;@78<;7'AA<7*==0>A@B?C@1B==<><=3C@?:2>;.5>@7>?<=3/?;CAC<<<>&>6;;=*BA99?8<;9>=4B=AA>=>8>;2<8-7#168==88'=@;??=:1'.7'3>=76497-B=500>6081:;;8<:6;2?858<;<7:*8:<77804-634/>48645:6>?3(:83>:6<8;<8=805:=8=,1697<56205329*;8>;=:98<7:>=99*669<8675615.92<83*43::;456=27>55+5),))2?>44937843>:7588098;=2<(:;1==9:&77:;;8778784138:9:;>;5572:/23,3<745<::=98?5=>=259>=<<:>?;:?898=>;>;8.;/<7+/>8?<=>.86=<>:7+2-8863$082:7739:<:>8:;&98225*71/9;2927&83:9??:03;;57688(<<>79+4?9979=8:>>;373=:?8;=/?6/<.?2;:6=;7=:17:96:9>;:;9<69:427.8;99=:;53,7;=<>:9+5;27529>86-687<;9978?5=><111:77><=68661<5>>=:2974<8;84=1;7;9;4<7<;466,?:9:8+8;<:+:7$79;;9==?7>84+7%8;><<898>>8;=:>>:?2;2<=49<479386:72?7<:<:595:8+:?;>?9>>76*=:775'-558>=8<;;8<8/;:7393<=>93;67);1>;>;9?;8=382;/;-3471<8=<>,4995:59:;==6>7=7::74:===*=:9>;9>>:9;9?==>>;;;83617:)6628878;<4<87;8=>>>=:>:6:8+::6:6:69-919:58<=39;<=>+6=;253;:7;=;=>5>89::=?;83=3<193$+757<569;8507;18:>:?:9:>>;?793=5:1/*%.29847<'/==;;<)<79>>;89>75<76:=88;0:/='9)7><1=?><::;:8<7:4;;=9??49>>;<<=;:;::+5377=<:4;:;5.=38<>:<:9:98+06:;:069><89:+2=08<<669*=??;==2;76<:;>>>;99?2:,=8;<>6:>><-798;88501965<8*38)039'=<70?;9:*>,>;?90;818890%23:-9:82<3?9=4<<+99=93;:>=8:53<=?8:97=48?:=5=%=67>>74%387:69;>:>?6?>;6;=:+=<<>8=;>>+=;-6<=(;6>?:;9:*;(=*<>06>71<>;98;<9<-=99802<<9-=8;7=<9:8<+:3>9%-9;;7077=<8<660<:3+0:?0;;:;:>849;50<<=-;579<+5;;==3=99><,7;>565;==>>>,=;6:;%=;:;9>>>==;8(:>:<9:9=*:==.:9;42+8>;99(87+<77:;;9):>>;8::>94=:><:*:>=9>69?9?9<==/8;.;3<8>2<<8;,;??=389&<281;<3>:=3 @rCer/1709/1907_60_CCS ATGGGGGGGAGGACCTTGCGTGGCCAGACCGTGCTGGTGACTTGTCCACACTGCTCGCTGCAGATACTCCAGGCGTCTCCCGTTGCGGCTGCTCCCTGCCTTAGAGGCCAGCCTTGGACACTTGCTGCCCCTTTCCAGCCCGGATTCTGGGGTCCTTCCCTCTGAGCCAACATCTGGGTCCTGCCTTCGACACCACCCCTAGGCTTCCTACCTTGTGCGCCTGGAGTCTGCCCCAGGGGCCCTTGTCCTGGGCCATGGTCCAGAATGGGGTCCTGGGGCCTGGGCAGCTGGGGGCTGTGGCCATTCTGCTCTATCTTGGATTATTCCGGTCGGGGACAGGAGCGGAAGGGGCAGAAGCCCCCTGCGGTGTGGCCCCCCAAGCACGTATCACAGGTGGCAGTAATGCAGTCCCCGGTCAGTGGCCCTGGCAGGTCAGCATCACCTATGAAGGCGTCCATGTGTGTGGTGGTTCTCTCGTGTCTGAGAAGTGGGTGCTGTCAGCTGCTCACTGCTTCCCCAGCGAGCACAGCAAGGAATCCTATGAGGTCAGGCTGGGAGCCCACCAGCTGGACTCCTACTCTGAGGACGCCAAGGTCAGCACCGTGGAGTACATCATCACCCACCCCAGCTACCTCCAGGAGGGCTCCCAGGGTGACATCGCACTCCTCCAACTCAGCAGCCCTGTCACCTTCTCCCGCTACATCCGACCCATCTGCCTCCCTGCAGCCAACGCCTCCTTCCCTAACGGCCTCCACTGCACTGTCACTGGCTGGGGCCATGTGGCCCCCTCAGTGAGCCTCCCGGCACCCAAGCCACTGCAGCAACTTGAGGTGCCTCTGATCAGTCGTGAGACGTGTAACTGCCTGTACAACATCGACGCCAAGCCTGAGGAGCCACACTTTGTCCAGGAGGACATGGTGTGTGCCGGCTACGTGGAGGGGGGCAAGGACGCCTGCCAGGGTGACTCTGGGGGCCCACTCTCCTGCCCTGTGGAGGGTCTCTGGTACCTGACGGGCATTGTGAGCTGGGGCGATGCCTGTGGGGCCCGCAACAGGCCTGGTGTGTACACTCTGGCCTCCAGCTATGCCTCCTGGATCCAAAGCAAGGCGACAGAACTCCAGCCTCGTGTGGTGCCCCAAACCCAGGAGTCCCAGCCCGACAGCAACCTCTGTAGCAGCCACCTGGCCTTCAACTCTGCCCCAGCCCAGGGCTTGCTGAGGCCCATCCTTTCCCTGCCTCTGGGCCTGGCTCTGGGTCTCCTCTCCCCATGGCTCAGCGAGCACTGAGCTGGTCCTGCTTCCAGGATGGATGCATCACACTCAAGGACAGGAGCCTGGTGTTTCCCTGATGGCTTTTGGACCCAGGGCCTGGCTTGAGCCACTCCTTCCTCCAGGACTCTGCGGGAGGCTGGGGCCCCATCTTGATCTTTGAGCCCATTCTTCTGGGTGTGCTCTTTGAGATCATAACTGAGAGTCAGGAGTTTCACTGCCTGTAGCGATGGCCAGAGCCTCTGGCCCCTCCTCCACTGTGGACCAGCCCATTGGCCAAGCTCCTGGGACCCTTGGCTATGAAAATGAGCCCTGGCTGCCACCTGTTTCTGGAAGACTGCTCCCAGCCTGCCTACCCAGCCTGATGGGCACATCCCTCTGCCCTCTCTCTGTGTTCCGGGCTGGGGCTGCCTTTGTGCAGCTTCGAGGACAGGAAAGGCCCCAATCTTGCCCACTAGCCGCTGAGTGCCCCCGAGCCCTGACTCCTGGACTCCGGAGGACTGAGCCCCCACCGGAACTGGGCTGAGGCTTGGATCTGGGGTGGGGGTAACAGGGCAGAAAGGATTAAAATGTTTGAGC + HJJKKKKK)IKIKKIKKKKKKKKKKKKJKDGJKKGKKKKKKKKIHKKKJKKKKDKKKKKKKJKKKKKJGKKKKKKKKKKKKKKKKKKKKKJFIIKIKKJKKKKKKKIKEFKKKKKCKKEKKKKKKJKKKKKKKHKKKKKKKKKKK0KKKKKKKKKJKKKKIKGJKKJKKKHJKIKKGDKKJJJKKKK@KJKIKKKJJKKKKKDKKKKKKAKK?KKKEKK@JKKKKKKJKKHKKKKKKJHKKKJKKKJKIKKKKKKKKKJJIKKCKKKJKKKKKKKGKKK9KIKKKKKFKKKKKKKKJKJKKJK>JIKFK?KKDKKGKKGKKKJKAKJKKJKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKJKKKK3KKKKEKKKFKKKKKKKKKJKKIKKKKKKFKKKKKKKKDIKKGKKJKKKKKKKKGKKKKKKKJKKK@KKKKKKHKKKKKKKKKKKJKJGKKKKFJKKKKKKKKKJKKEKKKKKJKKKJKKKKKKKJKKKKKKKIKKCKKKKJKKHHKKKKJKKKKAI%KKK:KKKJKFKKKKKJKKKKKKKIKIKKK;JKKKKKKKKKKKKKKJKKKKKKHK;KKKEIKKK?KKKKKK;KKKKKKKKKKKJKKKK7HJKKKKKKKKKKKKKKJJKKKKKKKJHKKHKJKKKKIKJKKKKJKKKKJKKKKKKKKKKKKKHEKKKKKKK*KKKHKKKKKKKKDKKKKKKK:KKKKJKJKKJHKKKKKKKKKKHKKKKKKKIIKKKIJKKKKKIKKKKKKKKKKKJKKKJKKKKKCKKKKKKKKK9KKKIKKKKKIKKAIKKKKKKKKKJAKKKIKKKKKKKKKKKKKKIJKKKJKJKHKKKKKKKKHKKGKKKKGKKJKGKKKKKKKKKJKKKKKKIKHKKKCKCJKKIKKKEKKKKKKKKKKKJKKKKKKK/KKKKKGKKKKKKJKKKKKKKKKKKKJKHKKKKKKKK?KKIKKKIKKKKIKKKKKJHKKKKK;KKKKKIKKKKKAKKKKKKKHKKKKKIKKKKJKKKFKKKKKKKKKIKHIKAKKKIKKKJKKJKKKGKKKKKJKEJKKKIKKKEKKDKKKKJKKKKKEKKKKKKIKKKJFIJJKKJKKKKKIIJKKKKJKKKKKHKKKKKKKKIKKK=KK=KKIJKKJKKJKKKJ>KKKGKKKKKFKEKJKKCKKCKKHJKKKHKK9KKGKKKKHKKKKKJKCKKKKJDEK(JKKKKK(KKKIHKKKKKKKKKKKK#KKKDKKKKKKKK#HJAIKJKKK,KKKKKJJBKKJKKK$GKKKJKKIKK?KKKJKKKJJKFKKK@KKGKKKJKKKAKK(KKDKKKIJKKKKKKKKKKKKKK?KKKCKKDKGKJJKKEGKHKKKK@KJKKKJKHKKJKKHKK:KKKKKKKHKFKKK'KKKK,JKKKKGKKKKKBKKKKKKKKKK:KKKBJKKBKKKKKIHKKK9KKKJKIKKKIK>KKKKKKKK=KKJKJKKK:KKKKHKKJKKJKKKKIHJHKJJJKKKKKKJKKKKKCKKBEKKKK@IKKKKKKKKKKKKHK>JKKKKKJIKKKKKKKKKEKKKKKGKKKKKJKKKHKKKK&KHKKGJKKK3KKKJKKKHKJKKEKKKJFKKKKKEJKEKKHJKKGKKKKKKKKKKIKKKJKEKIKK@KGJKJKJ2KBKKKFKKK5KKFKKKKDIKHKJJIDKKIJK>KKJKDKKKJJKJKK44IKK9KDKKIK$JKKKKKKIKKKKFKK@HIAIHKK8JKKKJHKKKGKFKKIKKKKK?KGKKJKJJKKKKJ7KIKJKJKKKFJKJKKKKKK6KKKKKKK<GKAKCKHKKKKKKGHKJKKKJKBKKKKKKIKGKKJKKKKKJKK7JJKJKKJKDKIKKKKKKJK?JKJKKFKKKKJJKJKKK6IIKKJKKJKKKIJKIKKKHKKKKKKK%GJJHJKKKKK2KHKKJKKKKJHKK8KK8KJKKFKKBKKKKJKKKKAKKKKJKJKKK=KKKGKJJK2KJEKFEF>KJKHKKKKIKJJJ>K(IKKIKKJKJKJKK2DBHKEFDAK$JK)DKKKKKEKKKDKHKK8CEKK8KKKJJKEJKDHKKAKJJKJKKKKJKGKGK8KKKIK @rCer/1711/30_1895_CCS CGGGGTACAGTTCGGTCCTGCTCCAAGGACTGCACTGTGAAGATCTGGAGCAACGACCTGACCATCTCGCTGCTGCACAGCGCGGACATGCGGCCTACAACTGGAGCTACACCCAGTTCTCCCAGTTCAACAAGGACGACTCGCTGCTGCTGGCCTCGGGGTGTTCTGGGCCGCACAACTCTCATCTGGCGAGATCGCTGTCATCAGCCTAGACTCCTTCGCGCTGCTGTCCCGCGTGCGGAACAAGCCCTACGACGTGTTTGGCTGTTGGCTCACCGAGACCAGCCTCATCTCGGGGAACCTGCACCGCATCGGAGACTCACCTCCTGCTCAGTGCTGTGGCTCAACAACGCCTTCCAGGACGTGGAGTCAGAGAATGTCAATGTGGTGAAGCGGTTGTTCAAGATCCAGAACCTCAACGCCAGCACCATCCGCACAGTGATGGTGGCCGACTGCAGCCGCTTCGACAGCCCTGACCTCCTGCTGGAAGCCGGCGACCCGGCCACATCCCCCTGCCGCATCTTTGACCTGGGCGGCGACAACGAGGAGGAGGTGGCTGGCCGGCCCCGCCCATGCCAAGGAGGGCTTGCGGCACTTCTGGACCGCGTGCTGGAGGGCGGCGCAGCCACAGCCATCGGAGCGCGTGCTAGAGACCAAGGTGGCCGAGCTGCTGGCCAGGGCCACACCAGCCCCCTGAGCGCAGTGCCACAGGCGCCAGGAGCAAGTACCTCATCTTCACCACTGGCTGCCTCACCTACTCCCCACACCAGATCGGCATCAAGCAGATCCTGCCACACCAGATGACAACGGCGGGGCCCGTGCTGGGCGAGGGCCGGGGCTCTGATGCTTCTTCGACGCGCTGGACACGTCATAGACGTGCACGGGCACATCATTGGCATGGGCCTGTCGCCCGACAACAGGTACCTGTATGTGAACAGCCGCGCCTGGCCCAGTGGTGCGGTGGTGGCCGACCCATGCAGCCGCCACCCATCGCAGAGGAGATTGACCTGCTGGTGTTCGACTCAAGACCATGCGGGAGGTGAGGCGGGCTCTGCGTGCGCACCGCGCCTACACGCCAACGACGAGTGCTTTTTCATCTTCCTGGACGTCAGCAGGGACTTCGTGGCCAGTGGGGCGAGGACCGGCACGGCTACATCTGGGACCGCCACTACAACATCTGCTTGGCCAAGCTGCGGCACGAGGATGTGGTCAACTCAGTGGCCTTCAGTCCCAGGGCAGGAGCTGCTGCTCACGGCCAGCGACGATGCCACCATCAAAGCCTGGCGCTCCCCACGCACCGTGCGCGTCTTCCAGGCACGTCGTCCGCGGCCTCGCGCCTTCTTCTCCTGGCTTGCCAGCCAGAGGCGCTGAGGGTGCTGCAGGGTGCACTGGAGCCGCTGGGATCCCTCGACGCCACCCAGGCTCTGTGGTTCTTTCCCGAGCGGGAGAGGTGGAGACGCTTGTAGCAGTTACGCCTTAGGAAGGGGACAGCCAGGCCCGCCACGCTCTCACACGCAAACCTGCTCACGCAGCTGTGATGCTTGGCACAGGGTGGCCAGTGAGGTTGAAACCCAAGGTCCCTTGGCCTCCTGGCCAGCTTGGGTGCACAGGATACTGGGGGTGCCGCTCCTCGCTCATCCCTAGGCTAGGGTTCACCCGCCCAGCTGGCCTCAGCCTGGGGCACCCTCGGCTGGTCCTGCGGGGCCCTGGACAGTGGCCCAGCAGTGGCAGAGGCTGCTGGCTCTGGCAGCCTGGCTGTGGTTGTGCGCCCGGGGCTTGGGAGCGGCCAGTCACACTGCTGTGGGCCCGAGTGTGTTGCATGTCCACGCACCACCCGTTCAGGGCCTGAATAAACAGTTGGCAAC + &$(&(*,&++&,,,#&&/01))%,,1-000/010).00-(11.1,/*/-..(-,/0+-0(+)./*+.--(-4+11113+/22216221/121-%7.46*5%66;344.412+6505*244'5526186.8/199;:9/.'3770+3614-..2(7-3)8581534(1'2/$-633/*.&"$//*1870798236827:97:789046,:42531+%4*61888/15;-,.)25)41-6;8969;)913>>496:345-*-2/)/,47688;1899+13+386==>136=<83>;';;9(21:6457/?><49:+<951,$65/79471862=9;377:6/-7175:?<.70:(8,138648962.,*763494720=37:<2<6;:.4*76=<;:>,663880<4/%*:<<,;4>==/<899=:961)7184?>:5..8155/5;52:44.745=>9+/A@7689=)A<5A?';+0;75.54:8C4?359:&:<<;4>6>=:4<78CB@?1>?2=@B>C@96;09<;;=@86B3,>;=A?005'@42#???=8@B'615>7?)<156=84?96===8=774&653%;57=6:=@<<>B6=94=1=<=9@75>9188-+2==?.?9C9);,==9?8894<33$62+:97A8;?39*8(3524725/86568;<2325;0:5*1;46?;;6.;88;*5:78=<6A60484528:975.84+:02&489+A>;-54':-60AA(?591/2:=A=B,=91.*<69/;=%>==287<+>;?;;'C/A:B?/28B048(4=>.::=;9BB?>=:=6(::BB?:;>;:B?<(37=/?>-64(=:=8C+:==?9AA4?>;*;3*AAA>:6?45&839+<5>458>8:/>?3<3<.6=&/:6C7B?<<:.C>=<4=32<7:>.;?>@?.?@8C><69@.5:>:CB>A7<@8%:1A8;7A@=.A>@7$49*9978B8B@;1?=:0BBB=39<+>=18.,6.7>90?0:3=19<59;3?3=CB=8==@,BB?<8+;;2?-847??>B@?=>AB0=@?9>B8:=3B9=4?<#=8&'33:@@:C>C<79@C@B714@@4+>@<6>?7C>;7;>8>8;<57=:4C@;>A.BA?@>>BC9-?6>47AA'?*=38;4:9)5<4(0&96'8:9;,?0?A<98>@;@9A=@A6><=>93)<;4<79<>>C?>?29?>C?3?=90<7;8B?A?A<=?9>/-?<:4>33;<;<:6075;3<7;8:@0A>9>654242A=8C;/:;4;>;?A6@<>22;=$>=>A>=;A?1<:35=>?>:C>CBBC?92>=8219?7=<9C>2C8,<;:8GBE=AFE8D5DC0BA<>E?E?C-AE57-7@80A=/4.5=.6<47>@;;3D<<<3@>?@0=:D8@BA>=-;>?@:8#?8<8B?A597<6:94:=6B*BA<0;?@DA4?,;5=A?A5?1:/)<<.:98D=A1*?;.;,;:B:4<=7?@AA<;6:8B<8;1:==31/22-4-CA@;13=EAC?8FE>C=?@@50DF@52B57<%;<1??8;CA=$<70@@C?D?C>DB(CEA*?;=9C:5A9:;.?@B0=8>?;EDB@>'>;=B?4B94>6FD@D@7D;8?CBDGDBCC6665:==A>B349C=@1;G*?:;9BEG>GBBCA:B?5?A&;74@>>AA9>A?6A=@A>:>,AB:,>@3(:'%=6<8:<+88=8:;;>8 @rCer/1713/0_742_CCS ACATTGATGCCGAATGGTATCCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAAGAGAATAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGAAATGCCTGGGGGATTCCCTGGGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACTATTGAAGAGGTTGATTAAGCCAACCCAAGTATAGGTGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATTGGC + S$&##$&#&'+%+,,**(%)#$'&'&++'),(++--,*+--*--.-,,'((%)+$,++),-*-+,,'()-(*%'+,*('$&$'$'+,*.-&()((*,'%+)))-(+&')(&--+-%&'*-)''()+,-**-+,,&),,+*+,*-,++*--.-**,+,$*(**)'&'+-,),-(,+(+,*,')%(%(-(*(++',))&)#&'$)+'&+,-%()010)/0/1)//0101+-,,&-*.)+**('+,*+(*(%),(,1+.0(,,+'%-./%()+.-$**.**-'#)0,0///,*)'$+///2-1+%*,-*+&&.,-.12.+/)*',-10)/001+*1*-*--')%,+)*++*))++--0)0&*%))+++,+&((,('$.++/&)+,,'+*++'*+%+*%&*-'--01+-/+,+00-,0/01,.2,'0-'$-,-1.2,%--.'(&-+01($*'%++11,..01''/0,0--2'-201/*1,.,++/.2*21.-,+&..,0+)*-)11-/10,)/1)/(0.-2*0-.**+$-.-+$*)./.-+,+-1-*.02*1021-*010'0+0*/.0)4-*120*'15.64&1++04+%.455+23503666216.41/44241(%*/-01.030**16-,3514115432461/.1,5163351-/6352$1//05&)%*,10+.-01/-,.02+,%***,,+-/-/011+,,0..+2220.1/00111.0,11/*010//.*/,#--,.0/20 @rCer/1717/1539_53_CCS ATGGGGCCTTTCTTTGCGGAATCACCATGGCGGCTGGGACCCTGTATACGTATCCTGAAAACTGGAGGGCCTTCAAGGCTCTCATCGCTGCACAATACAGCGGGGCTCAGGTCCGCGTGCTCTCCGCACCACCCCACTTCCATTTTGGCCAAACCAACCGCACCCCTGAATTTCTCCGCAAATTTCCTGCCGGCAAGGTTCCAGCATTTGAGGGTGACGATGGATTCTGTGTGTTTGAGAGCAACGCCATTGCCTACTATGTGAGCAATGAGGAGCTGCGGGGAAGTACTCCAGAGGCAGCAGCCCAGGTGGTGCAGTGGGTGAGCTTTGCTGATTCCGACATAGTGCCCCCAGCCAGTACCTGGGTATTCCCCACCTTGGGCATCATGCACCACAACAAACAGGCCACTGAGAATGCAAAGGAGGAAGTGAGGCGAATTCTGGGGCTGCTGGATGCTCACTTGAAGACGAGGACTTTTCTGGTGGGCGAACGAGTGACATTGGCTGACATCACAGTTGTCTGCACCCTGTTGTGGCTCTATAAGCAGGTCCTAGAGCCTTCTTTCCGCCAGGCCTTTCCCAATACCAACCGCTGGTTCCTCACCTGCATTAATCAGCCCCAGTTCCGGGCTGTCTTGGGGGAAGTGAAGCTGTGTGAGAAGATGGCCCAGTTTGATGCTAAAAAGTTTGCAGAGACCCAGCCTAAAAAAGATACACCACGGAAAGAGAAGGGTTCACGGGAAGAGAAGCAGAAGCCCCAGGCTGAGCGGAAGGAGGAGAAAAAGGCGGCTGCCCCTGCTCCTGAGGAGGAGATGGATGAATGTGAGCAGGCGCTGGCTGCTGAGCCCAAGGCCAAGGACCCCTTCGCTCACTTGCCCAAGAGTACCTTTGTGTTGGATGAATTTAAGCGCAAGTACTCCAATGAGGACACACTCTCTGTGGCACTGCCATATTTCTGGGAACACTTTGATAAGGACGGCTGGTCCCTGTGGTACTCAGAGTATCGCTTCCCTGAAGAACTCACTCAGACCTTCATGAGCTGCAATCTCATCACTGGAATGTTCCAGCGACTGGACAAGCTGAGGAAGAATGCCTTCGCCAGTGTCATCCTCTTTGGAACCAACAACAGCAGCTCCATTTCTGGAGTCTGGGTCTTCCGAGGCCAGGAGCTTGCCTTTCCGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACGCTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTTGCCATCGCCTAGCTGCCTGCACCTGCCCTTCAGGGAGATGGGGGTCATTAAAGGAAACTGAACATTGAACCCTTTCCTGTCCTGCCTCCTTTGTGAGTGGTGGCGTCTCCAAGGGGAGTAAACATGTTGAAGCAGGG + 8=AAC=@=?C?3=<9;9=<@=AA;B>:8$*=67<7+4;2@A?<8;7;>><:,<<:?7>?5=:<7362E<<::?E>@CC:DE?BCBB?FEFDFAF=DDG@@CAB?BA5?=9AE@ECDB?BB=E;FFC;@ACBBB7B;D@CECAA?4G@B@@ECF8GCAABC3<>@;DGG=9@C8EEE6@@IEIFHIFDFHFDA:GID7F?GEFBCGH:>GBFBHEIEHGFFE2@:&BA?ABEFH>A3GCBDHFFF8F>GHIIBIB>HBIGJJGHIKBH@HHHD@CGHGF>EFI=>92CICC@IFBEIKGKICKJIG3GIIDIHGFKI>JJK>KJF7GJ7=J>JIKIIKKKKKBGJ@IFGD5:KHDKKDKKKICKJ=J7JAKKECKJHHKKFJKIIKDJKKKJIKHIHEKFIK:E>KHJJIDBIKJJ9JIHKHIHKGFG=JIK9IAIJFKBGIHKJKJEBKKKIKIKEJKJGHJ6I?HJJIFCIKBHKKDH>CJIGIK@HI5IJGE7JEHBIH2KJ9K7EDKKKGJF>IDKEJH@HFGGCIJKKKJJFKDH;JAIFIHHJ@IJJKKHIIDG.F;IG/@D4FIKGJHADIC7EDHGIKJ4EHGKGGDC?=GG?EGGIJI;KKKJIJKKFJJHHFEKIJCGFHKKCIJJFJEI;JIHKKGJGKKKIGKFKKKJJKKIGJKGHHI=0HHH5IHKKI)EKJJH>K>J-J:DBIKFE@CF5IKKHJKCJ>DIFKGIHJFEDKK>II8KJJJJKIFHK8?FBJG@CGFHHFKJ@KIIKK=KKDKHKKK/FF@JI4CGFBJ,HI;KKJKJJ @rCer/1722/25_1877_CCS ATGGGGAGTCAGTCCGGAGGCTGCGGCTGCAGAGGTAACGCCTGCGGAGAAACTGCAAAGATGCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCCTCGGCGGGCCGGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCCTCTAACACTCATTCTTCAGAAGACTGGGACTGCTGAGATGTCCTCTATTCTTGAAGAGCGTATTCTTGGAGCTGATATCTCTGTTGACCTTGAAGAAACTGGGCGTGTCTTAAGTATTGGTGATGGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAGAAATGGTAGAGTTTTCTTCAGGTTTAAAGGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGAGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGGTCCAATTGGTTCCAAGACCCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCAGTGCGGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCTGCCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCTGTTGCTGCGCCGTCCCCCTGGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATTGTTGGAGAGAGCAGCCAAAATGAACGATGCTTTTGGTGGTGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTTCCATCACTGATGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTATCTGTGTCTCGTGTCGGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTTGGTTCTGACCTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGACAGTATTCTCCCATGGCTATTGAAGAACAAGTGGCTGTTATCTATGCGGGTGTAAGGGGCTATCTTGATAAACTGGAGCCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACCAAGCCCTGTTGGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAAGTTCTTGGCTGGATTTGAAGCTTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAAATAAAGGTTCCATAAT + ?>-BA:4496&:<;87=:4<<<>=:>@>1884--7;=/>?;?C=0;2545<==-639;67598:48:48=:7=>?<?99'84>=<@=B>>C;?<>B=@===<9>;9B==5:?=53=ABA58B=>@;8>@DAF9AD@0E<>@I@GI=II4IH@C=CFBEB=HEB=6:FE>=FC=;BIC?A;CED@5DFE?%A@HHA9DA>IH>>7;@=B,6>>GGCEA?D,FCIFAEID:CBA=3CBEBD8@>?;>>;1;BA=;8E>EEB<>DE7<:5=>BCE2GCE::>;C>C;=D;?B=:@;37?@8@>DBDCEF8EC/CFI8E.=.?EC:CFEC*E?9AH<60->@CE>F7DIGA;C@DF?>BEG?HH9>E,CCHCEFGFEGJ=9?GAF:A;C:9EH<5ACE>BGBI7BDEEB;=@=BG:B@B>H8D?EF6AEBA17?BBICIGCEFGB>?8@:)C6@>88BFJCGF8;>FEC94><7B=FF7=2>B>1@<;D==@?:=E?EB:F>7F8A@@8FG@9@DDHGJBAIFJFICBA=D:FIHHBDA:EIHCIH>F>AAGEBGAFFFCJ@CEBG:GCDD;HGJ>H*@3ADDED=-CF=@E;EGEH>JCFBB?>FECGEHIGIIHIH59.G?FECFG=9?A1GHD@EHIEFEGFC@4CHDEGIE;I@FAGACDGEBI=C=<:FIHEGIE+CCGCIGBABFD@IDDCJFHI?AE;D6CDCCDA3E?AFHH@@;E>=;-<8+19CG@CH?ABFF4?B9HHID:A>:E>DCACHB0:BGB>>EF>?7D?8=?D7H>>DAFIDE:9BCIH/>BIEJID7=DAC?G<@;993@D>CDG?18;;@@@/33828B?=?B@EBBB=@?.@>?<>CD29;9=CE>@D?/C9<;=B8CCB>(AC@C8D?@?>=@6:;FEE<5=:C?B=<;@=9@B1CDDD;C7DEGFC@F:DCDBBFAABCBC@AEC>GDBC>;7DCE=C?C=;8@?79?C:A=CEF??C@?=8A5F@9;/>@;9AA:EDAE3A>;DGA@>:A@@;FC96EFCBB?@AAE33:?;95@=E7>:0@C@F3B6><;A>/><;=@F>=;8DF>BBA?C?B;>6@GBB?BCAFB<=AC?CA4F?B=6@?EGBE@F@A@=BD?@EAECDDDEEA=@;9D9A:@A@CBF?@%C??1A>>BC6@:?@C?BECEEAA?DBEA9FB;@0B@CFA377.3AA?AEC;A6BFD?E:A?DGAAEFAF4>5<5;)>>2C59,'@F;A=7..?D==15,4)=9;4'63'0+4?@2.'?59>@:9B>C>>E=DB>;+?A=D=DAFF;9?/;,>0AFG-?ABC=F;;%>BEKBC>IC0>GIE:=7>:;&KH7>1BHBJI1GJI20B?7)A9E9J7%&;HFJ1I>2:BAIC6H@9JH-A;K5FBG=?)4E4/C93K6<7EK-JF9)@B;?E@9>85.;F<%7;6@GA1&%7:?<8G57==BFF80:B2B?16.@C?HK>GHJGKBEF=1GIEB?4;'6=HK9>95(?B5=;AG>F:IID=?,.8+A<%?(?@?AD,AAFE>C&DCH>=;=H?A>A;-4C'<:72:I;9:D:;0.;7=E0>*?E@J6@>C>CDDGFA0?@:A?;?5B45@DD#:0@8BDB;58A=@A:D8CG95>D7F$3BH5B@<*?=<<<)>C=CAC@0B-38EA=E>C?=;FDGI*=>8B(A?5=;H4E=FE3F:IGJ7JDCKG0=@FDDF;2GHI/HFDHAC>7BAI+(>=8%*)AJB'44I-?@::@EJE?3&G;9K&=%=@JBI4(?FJFI=G3GJE?F8HEKH?KB@)1H@72%DBD=<4=8>CJ:58(=G84(C=0J@K<1?@G<2>;5HKIB%H9H8C;CCDG==>=5DGJFJK:IC&<08;D$/=KD--C@4E7A5;7KI=A>87@A53@G7F7CDIFJCJGA(EK6KI76JJC0C6AAFFJJBKHIG%8?5J+GJ>;FK8A=AC@D:C'D.1?H<1EC;AHH?BG@-ED:HDHJGD;HD7J:B9<+>8EI+HH)B%C1GG@@=&;;?DBIHG>==6$8;-HE<@GFCC'&B:=$/E=9G?IF.F8?KI)>@5AB40%FJ<<=C:9656=::761726=><60;2=3=97>>:<7;79;=727=48><;?=8=;:69><7-:=>===97<6;873:692573==;9==8=;:948;99<669<9=>99:;>>=;967;4:.<1;36>:9;6,7068499;6=3:;;27/76;6;:389>=3><7:;11==<::/>;89479::?8<=35108>>04*>;39:84<7=1879;15;9:6><>2=:9=6:8::><227.34<=/46)+*<=5=145<>76=>7:3.9;9<65-/759:;>;941<;>=>39?9=74;>::5<73:<=9=859;97;89113/1/73<:;7<4;<>7=537:>=9=29;=1886+79:=;96<69%9:6<,;==99>>===>>5456:<<1577=3=866?:<:;<8.(559:8-95=<;<:48+86/762:;:98:257,54?;69<998.95<0*58';91<1>:;=39?8<;+7448686+1826'=6=<98=2>;:9=<>7;96,):$;074?<86>4:6<#01=<9>=7<4<:4:7?<:8=:>==?>8;7>8>>2+:9;:=:>>;9??5>3<>450=:6$;3><989<<=96>9726/++;67876<655<9821/2*8;<:7377::1=;6=8/988<2<9<;9*861170.12,<99=899<;<<:<22?;>=999==9:<8.182,:7;93:4=:;5-618<7*/288*;73*=<:69383<:14=41774:;79085=7><=763<:9:67:1;?>>=;:8/>>>;3(66%445,+&$*/432//731449:/5-68691=>;8<05:09757(.157-);97:7;;55:3895673;:>;=18666:>7=?<589::<7;8550735=6780601/1052,+2/23=:/42799>:3513?74;5475=3<>531=;78525787027-0<28=58;501.6/27398:14789;/27<949>5>945:5;37;755:305.>=83<<=88932::+:7869;:85085,5889134.;758<:4<7<=8:95.2+1:7:17/990;3;881:,;375/)55&3::72<:4;5,(073;7*/67,319647137:=8699721%8,)073562996,1//-61;8<69998>41;095;<>57:3/75/108;=66<8625>;:=&(7699%=>:4===79::1379:81/773*.+8165835:85966928:4.60'96:4.36)'71241973541;675883;79642;:956668.7:8;6:;8:7:975/4006+564/77757-5543,73977595699/8282655078/$7357959125785$5:86;97993995::363:812327+1&26686478:96635498+799714,4'-+498,89.5:2278736596697:98739582951110147764:43.5.1&73.74283355133:75(,63553987--395)5765916890;889::2:577-65896621(-4:75985:69:8-.2.96.8578:6585:7840:)39299=9>9>6<:5972796:<;*:3?4?:;<66<5:+<5>;68<3805=6749'<;6=:>35=??3=<==?:;<=8<8;?7;:;6117106:;788+6=;2:9>:9;7/71;?<==.6-$>=;9;=889-6;4>=<9:9+><8-26-39;8>?====941;7387=167;6=1>?:>=>;98>6/27>68>7=:5>=>:956=;.3>><7=989?84:<=;.<>=7;8=48 @rCer/1727/25_1710_CCS ATGGGGGGGTGGAGCGTGCTCGCGGATGGGCGGTGGCGGCGGCGGCCTCGCGAAGGTTCCAGATCCGTCGCGTGCGGGAGGCGGGCTGCGATCTCGCGCAGGTGGTCGGTGGTGCTCGCGGGCTGCGGCGCCGCGACTCGTGCGAGTGCGGCGTCTGCGCTCGGTTTGAGGGCTCCGCGCGGCGTTTCCTGTTCTCTCCTCTCCGCGGCTGCAGCTCGGGCCTTCGGCCTGATCCAGCCCCCATGGCTTCAGAAGAGCTACAGAAAGATCTAGAAGAGGTAAAGGTGTTGCTGGAAAAGGCTACTAGGAGAAAGAGCTAGTGATGCCCTTACAGGCTGAAAAGTCCAAGATTGAGACAGAAATCAAGAACAAGATTGCAACAGAAATCACAGAAGAAAGCAAGAACTTCTTGATAATGAAAAACCAGCTGCTGTGGTTGCTCCCATTACAACCGGCTATACAGTGAAAATCAGTAAGTTTATGGATGGGATCAGTCAGATAAGTTTGTGAAAAATCCTTACATTACCTTGAGTGGAGTGCATCAAGTTCCCACTGAGAATGTGCAGGTGCATTTCACAGAGAGGTCATTCGATCTTTTGGTAAAGAATCTAAATGGGAAGAGTTACTCCCATGATTGTGAACATCTCTTGAAACCCATCTCTGTGGAAGGCAGTTTCAAAAAAAGTCAAGACTGAATACAGTTCTTATATTGTGTTAGAAAGAAAGTGGAAAACACATGGTGGGATTACCTGACCCCAGGTTGAAAAAAGAGTGCAAAGAAAAAGAGAAGCCCTCCTATGACACTGAAACAGATCCTAGTGAGGGATTTGATGAAATGTTCTAAAGAAAAATTTATGAAGAATGGAGATGATGATATGAAGAGAACCATTAATAAAGCCTGGGTGGAATCAAGAGAGAAGCAAGCCAAAGGAGACACGGAATTTTTGAGACTTTGAGGTCCTTTTGGGAACTGTGATGTGATGTGGGAAATACTGATTTTCCAGTAAGGGAATATTGGTGAGCTGCATATATAAATTCGACAGATAGCTATTTACATAGCCTTCTAAGTAAAGGCAGTGAATTCTCCCATTTCCTACTGGAGGATTTATTTAAATAAAATATGCTTATTAAACACTCCCTCGCAAAAGATGGTTTTATTAGTACCTTGGTCATTTTGTTCAAGGAAGGGTATAATTGCATTTCTCATGTGAAATATAAAAAGCAAGTCTTGACCCAATAAAAACGCTACATTGTGTGTATTTTTTGTTCAGCTAAGAATTGGAAAAGTATTTGCTTGGCCTTTAAGTTACTGACATCAGCTTCCACCAGTGTAAAAATTGAGGTAAAACCTGAAGTTTTGCATAAAATGCAGATCGGTACCTGTGCTTGGAAGGTTGCTGGTAGAAGCATCTGACCCCTTATTACCACCTTAAGCAATGTGTATGCCATGCAATTACCATGCACTAATTCAATCACAGGTGTTTCTATCTAGATTGAAATATGTTTGTTCAATGAATATAGAATAGAAACTAAATCTAAACATGACAATAATAGACACACATCTTTGTATGGTACCAGTTAGTTTTGCCGTGGATCAGATGGTTTATGAAAGTAATAACCATAAAGCAAAAAATAAATCTGAAAGCCCGTCTATTCCTATGCTCAATAAAGTTAAGTTTTTCTTC + *'")(''$"%'-*,,*)*&%&'$&'%&$&%"$&$$$'&($"%$#%%*&+&*'$%$,$'*+%+&%%%&&"###"#%"#$#"#&&)**&)*(*''))*'(*'%)$"''#%)'###%%(&()#'&$*))$&#%%&''$','*')*)''%&$!#$&)#%'++()*+$'%,%#$(-,+*%+',*)&-())*)#'')),'+'(),++(%$+'$'&)+++-*,,),+%($*'%&$&(%(&%($($'*'++)'-*$+(+$&,'++-,()*,+(-())&&($()*($($#(&&-)'%(*%($)%',)#$'%')'&$&##$'$%(($$$#$)*)(#%$#"#'##%&(,'%%+++&&&(&)')-+(+($"#&'('&-'%%((%$$$$'(%+,-,')+),((,)+,'#%''+%(,-.*%&%'%&%'*)+(#)(''+-*,%))%'&*+-(*'$#&+'%$**("#""$&%')))$$'('$(++'&&%""#"$$+)%'*%+*,)%($(,++'&$%%,,'')')+"%&((&$#%))&&')#&('+(++&*+)""'*(()%)+%+$(*+**&*&*,*'()''&+))&&'+(%(%'',)'&*$&(**(*&('$-,,%(%#(((*+%+*(*()$&((+*')'(+)($&'()$)&'&&))-%#(*(''$((+*)'*)*(()&')(,%+(-+,,#$$)#)'%%%#&$'%'**)+($('*)()*+))-('+&'(')%))((+*%&+-)&#(#+)'')'((%+()+,+&+$$#$('#($$'),)-)$''+'$&')&()(,,++..-,+(($(($',)''%*'%)+,++)'+*''*),$)&)),,*%%()#)(((,,#)&)+(*'+*),&#)+*&%)+&+$'%$"%%'&%%*'*(*)(&'&)$)((()-),*%("$&#$&)+))'(,**)$*'%(*'**%#$)((%,+')*,.,,*)+++**$'.$))**+-)--(+($)$)#),#'&)%,($+(()&')))--+*+'#&'(+-'(**(&#$+(*-)&,(.*-+()&(,-(&*()&,*,+'('&$#&'*$+'(,++*+*+)++*$%))+++,,()),&(+(--(,*$&(,)++%').+)%(*)(**'(#&&$&),(,'+.--,.,&*)'$)($%&'')%'(&%$'((&'$$'($"'%$&'''((%($#)&"#%$%'##'%)$%'#%#&%&%$((&'$$'(&(%#$((((&('&"$&'&'''$('&&%$((&()))'($&''%#'&#$$&%%$#(&$(*)+,+&*&&('))+%#%--*&(').*-+)+',$'+)+(&%+..+&%&+,',(*$')-(),,-+&*++(*-,-*()*+(,(-,%-'+&+,%',,,+-'+%(,(,*--*+*)',*-,),+-))*,.+)),+$)*&*,)*-*---**,$(,-'$',')($%'**$'+&())-*()-+)(++%*+%(%).'($,+)**&(*)%(+*,,))--$%&)&,*+*+',)'*-'-,,,(-*-,&,'((+****-+-+)+*-,&,'%'(%#$&'$$'(((*+,''%+(),*$(&*,))(,-*-,),,$(+--,)-+(*(**,&++*'*)+(+***,++),%'*&*(++,)+--++-+*+*-('$***--'+*('(,-*)'()+)+,*(()-,(*),----*"(&(,+)(')*%#'(+('-)-(+*,,($)+*)(%++,+-','#)--,,+.- @rCer/1731/1614_58_CCS ATGGGGAGCGGGAGGAGGAGGCAGAGAGCACAGCATCGTCTGAGACCGGACTCCTGTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGGCCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTCCTTTTGCCTCTTAGGCATCGCCTATGCCCTGCCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGTTAAAGCCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCTTCCGAAGAAACCAATGACTTTAAACAAGAGACCCTTCCAAGTAAGTCTAACGAAAGCCATGACCACATGGATGATGTGGATGATGAAGATGATGATGACCATGTGGACAGCCAGGACTCCATCGACTCGAATGACTCTGATGAAGTAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTCTGATGAATCCGATGAACTGGTTACTGATTTTCCCACAGACCTGCCAGCAACTGAAGTTTTCACTCCAGTTGTCCCCACAGTAGACATATATGATGGCCGAGGTGATAGTGTGGCTTATGGACTGAGGTCAAAATCTAAGAAGTTCCGCAGACCTGACATCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACATGTGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCAGTTGTCCAGGGCCTGAACGTGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTCATGAAACGAGTCAGCTGGATGACCACAGTGCTGAAACCCACAGCCACAAGCACTCCAGATTATATAAGCGGAAAGCCAGTGATGACAGCAATGAGCATTCCGATGTGATTGACAGTCAGGAACGTTCCAAAATCAGCCATGAATTCCACAGCCATGAAGATATGCTGGTTGTAGACCCTAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGCATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAAATATAATTTCTCACTTTGCTTTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTACCTATGTGAATCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTCGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTACGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTTTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTCTGTTTTTTAAGTTAGTGTATATTTTGTTGTGACTATCTTTCTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAGTAAGAATCTGGTGGTGTCAATTGCTTACTTGTTTTCCCACAGTTGTCCAGCAATTAATAAAACATGATCTTTTTTACTGC + KKKKKJKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKKKK9KKKKKKKKKKKKKKKKKKKKKKKKJKKKKJKKKKKKKKKKKKKKKKKKKKK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKJKK8KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKK9KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKK @rCer/1732/25_1600_CCS ATGGGGGGACAGCCCCGGGCCCCGCGGGCCGTCCGTTCGGCTCCGGGGTGTGTTACCCAAAGAATGATAAAGTTGGTTTTATTTCAAGAAGTCGATCGAAAAGAAAGCCTCAGCGTCTAGAGTTCAGCTGACGGGAAAGGGGGTGCGCAGCCTCGAGTTTGAGAGCTATCCGGAGCCCCAAAACAGGGGTGGGCGCCAGCTCCCTGCACGCCCTGAGCTTCTATCGTAGGCCGGACCATGGGAACCCCAAAGCCACGGATCCTGCCCTGGCTGGTGTCGCAGCTGGACCTGGGGCAACTGGAGGGCGTGGCCTGGGTGAACGAGAGCCGCACGCGCTTCCGCATCCCTTGGAAGCACGGCCTACGGCAGGATGCACAGGAGGAGGATTTCAGAATCTTCCAGGCCTGGGCCGAGGCCACTGGTGCGCACGTTCCCGGGAGGGATAAGCCAGACCTGCCAACCTGGAAGAGGAATTTCCGTTCTGCCCTCAACCGCAAAGATGGGTTGTGTTTAGCAGAGGACCGGAGCAAGGACCCTCACGACCCACATAAGATCTACGAGTTTGTGAACTCAGGAGTTGGGGACTTTTCCCAGCCAGACTCCTCTCCGGACACCAATGGCGGAGGCAGTACTTCTGATACCCAGGAAAACATTCTGGATGAGTTACTGGGTAACATGGTGTTGGCCCACTGCCAGATCCAGGACCCCAAGCCTGGCTGTAGCCCCTCAGCACTTGCAGAGCCCCAGCTTGGACAGTCCCACTCCCTTCCCAAACCTGGAGCCCTCTGAGAACCCACTGAAGCGGCTGTTGGTGCCGGGGGAAGAGTGGGAGTTCGAGGTGACAGCCTTCTACCGGGGCCGCCAAGTCTTCCAGCAGACCATCTCCTGCCCGGAGGGCCTGCGGCTGGTGGGGTCCGAAGTGGGCGACAGGACGCTGCCTGGATGGCCAATCACACTGCCAGACCCTGGCATGTCCCTGACAGACAGGGGAGTGATGAGCTACGTGAGGCACGTGCTGAGCTCCCTGGGTGGGGGACTGGCTCTGCGGCGGGCCGGGCAGCGGCTCTGGGCCCAGCGGCTGGGGCACTGCCACACATACTGGGCAGTGAGCGAGGAGCTGCTCAACAGCGGGCATGGGCCTGATGGCGAGGTCCCCAAGGACAAGGAAGGAGGCGTGTTCGACCTGGGGCCCTTCATTGTAGATCTGATCACCTTCACAGAAGGAAGTGGACGCTCACCACGCTATGCCCTCTGGTTCTGTGTGGGGGAATCATGGCCCCAGGACCAGCCATGGACCAAGAGGCTCGTGATGGTCAAGGTTGTGCCCACGTGCCTCAGGGCCTTGGTAGAAATCGCCCGGGTAGGGGGTGCCTCCTCCCTGGAGAACACTGTGGACCTGCACATTTCCAACAGCCACCCACTGTCCCTCACCTCTGACCAGTACAAGGCCTACCTGCAGGACCTGGTGGAGGATATGGATTTCCAGGGCCCTGGGAGACCTGAGCCCTCGCTCCTCATGGTGTGGCCTCTAACCTCCCCACCCCCCACCACCTCAACCAATAAACTGGTTCCTGC + EE-B@@HHHFIICIAK9JH&IG>FD6FC@FHE9HFCKJ:IEFFI2IH;EB=6:GJDIKDEIKFHHG:IJKKI?JEKFKKKK?FHKCII8?>IKKGBHJ=DGCFCHEGBIGJJ@IJGHEGCFJGJJGDCHHDE0JF;JK@KKJIGIIFH?HHKGJKGI;HICFIJJIG?FJKBICDHJJI7GFJHJ=GIGI?HHGJHFIIJIGBJ@EKAJCJDIKHJEJF8D0IIB7IJHJJK@KKFCIK7FCKIJIJKIGK?JJJJABEHGHKFHJK8EAEFEHEHEJF3IIJIJHK8IICJAAJ=HEGEIIICKFGEICAGJ=HGGDHG9-HKBKDKHJDGEIHJEJBHIBFFICF?JJK=HGIKGCKIBJIEIKFFGAJHHIKAHGEJGFF?JH3??F;GFKHIIIKFGJBIGIFEI4DA;JEDBIKKCJIIBKJE>=8=GJJGJGJIGK@ICEIGBJAFHFIHGDFH>4B:?HKBJ0IHGCGHCD4BF@DIFAG;G?B;F@I(@CFFG?FB=B?$EDAF?9?5>><9=AFDF>CD:DDB=GA@5@DA@BFGF6G5EF@A@D;97A;BDHGCAF>AADD=>CGFF=AH??=A:=99@<;6CABFBDCE@?>B8?DABD;DB@CD@9AF@DBCF3FH?9BC<@:BBH=E>GE?DBA,=;BB@<>FEFCF;C@E4>A>GFFGFDDE/BF>GFAEJ>IFHCEIIHFI5AA+:CE@F;IGI@GAC8C@EA;A=@>CEIH@GBFE7CEIBJF:GEIABGBHDGFIFHFGHF>FEJ;@FDGHF?HCIGF6E=EHFEDBA>;=A=DIDCIACBACJC?;;E;C@EG:%=A<:9>88E:>=7>AFED>C?FEF9B3B>??;@>E?=>@5=?==;>8.><9A=5B;6>DEA>9?/:65C7?:B=;;CBC?BCD:/@@@@C?AAEG<:@;4DD8E>3@@9FEBG<=9=0?A6?@A17BA@@ACDFD?F;C7)?;9<(@;A<<;8FBD?CE.<9<.C<(7?>==D>E?@:;> @rCer/1733/3077_59_CCS ATGGGGCTTTTCATTGCGGGAGGAGAGGACAAAGATACTCAGAGAGAAAAAAGTAAAAAGACCGAAGAAGGAGGCTGGAGAGACCAGGATCCTTCTTCCAGCTGAACAAAGTCAGCCACAAAGCAGACTAGCCAGCCGGCTACAATTGGAGTCAGAGTCCCAAAGACATGGGCTTGTTAGAGTGCTGTGCAAGATGTCTGGTAGGGGCCCCCTTTGCTTCCCTGGTGGCCACTGGATTGTGTTTCTTTGGGGTGGCACTATTCTGTGGCTGTGGACATGAAGCCCTCACTGGCACAGAAAAGCTAATTGAGACCTATTTCTCCAAAAACTACCAGGACTATGAGTATCTCATCAATGTGATCCATGCCTTCCAGTATGTCATCTATGGAACTGCCTCTTTCTTCTTCCTTTATGGGGCCCTCCTGCTGGCTGAGGGCTTCTACACCACCGGCGCAGTCAGGCAGATCTTTGGCGACTACAAGACCACCATCTGCGGCAAGGGCCTGAGCGCAACGGTAACAGGGGCCAGAAGGGGAGGGGTTCCAGAGGCCAACATCAAGCTCATTCTTTGGAGCGGGTGTGTCATTGTTTGGGAAAATGGCTAGGACATCCCGACAAGTTTGTGGGCATCACCTATGCCCTGACCGTTGTGTGGCTCCTGGTGTTTGCCTGCTCTGCTGTGCCTGTGTACATTTACTTCAACACCTGGACCACCTGCCAGTCTATTGCCTTCCCCAGCAAGACCTCTGCCAGTATAGGCAGTCTCTGTGCTGATGCCAGAATGTATGGTGTTCTCCCATGGAATGCTTTCCCTGGCAAGGTTTGTGGCTCCAACCTTCTGTCCATCTGCAAAACAGCTGAGTTCCAAATGACCTTCCACCTGTTTATTGCTGCATTTGTGGGGGCTGCAGCTACACTGATTTCCCTGCTCACCTTCATGATTGCTGCCACTTACAACTTTGCCGTCCTTAAACTCATGGGCCGAGGCACCAAGTTCTGATCCCCCATAGAAATCCCCCTTTCTCTAATAGCGAGGCTCTAACCACACAGCCTACAATGCTGCGTCTCCCATCTTAACTCTTTGCCTTTGCCACCGACTGGCCCTCTTCTTACTTGACGAGTGTAACAAGAAAGGAGAGTCTTGCAGTGATTAAGGTCTCTCTTTGGACTCTCCCCTGTTATGTACCTCTTTCAGTCATTTTGCTTCACAGCTGGTTCCTGCTAGAAATGGGAAATGCCTAAGAAGATGACTCCCCAACTGCAAGTCACAAAGGAATGGAGGCTCTAATTGAATTTTCAAGCATCTCCTGAGGATCAGAAAGTAATTTCTTCTCAAAGAGTACTTCCACTGATGGAAACAAAGTGGAAGGAAAGATGCTCAGGTACAGAGAAGGAATGTCTTTGGTCCCCTTGCCATTTATAGGGGCCAAATATATTCTCTTTGGTGTACAAAACAGAATTCACTCTGGTCTCCCTATTACCACTGAAGACAGAAGAAAAAAGAATGTCAGAAAAACAATAAGAGTGTTTGCCCAAATCTGCCTATTGCAGCTGGGAGAAGGGGGTCAAAGCAAGGATCTTTCACCCACAGAAAGAGAGCACTGACCCCGATGGTGATGGACTACTGAAGCCCTAACTCAGCCAACCTTACTTACAGCATAAGGGAGCATAGAATCTGTGTAGACGAAGGGGGCATCTGGCCTTACACCTCATTAGGGAAGAGAAACAGGGTGTTGTCAGCATCTTCTCACTCCCTTCTCCTTGATAACAGCTACCATGACAACCCTGTGGTTTCCAAGGAGCTGAGAATAGAAGGAAACTAGCTTACATGAAAACAGACTGGCCTAAGGAGCAGCAGTTGCTGGTGGCTAACGGTGTAACCTGAGATGGCCCTCTGGTAGACACAGGATAGATAACTCTTTGGATAGCATGTCTTTTTTTCTTTAATTAGTTGTGTACTCTGGCCTCTGTCATATCTTCACAATGGTGCTCTTTTCATGGGGTATTATCCATTCAGTCATCGTAGGGGATTTGAAGATCTTGATTTGTTTTAGAATGATGCACATTTCGTGTATTCCAGTTTGTTTATTACTTATTTGGGATTGCATCAGAAGTGTCTGGAGAATAATTATTTGATTATGACTCTTTTTTAAAATAGGAAAATTGGACATTAAGCATCACAAATCATACTAAAAATTGGCTAGTTAAATGAATCTATTGGGATTTTCTATAAGTATTCTGCCTTTGCAGAAACAGATTTGGTGAATTTGAATCTCAATTTGAGTAATCTAATCGTTCTTTCTAGCTAATGGAAAAATGATTTTACTTAGCAGTGTTATCTTGGTGTGTTAAGAGTTAGGTTTAACATAAAGGTTATTTTCTCCTGATATAGATCACATAACAGAATGCACCAGTCATCAGCTATTCAGTTTGGTAAGCTTCCAGGAAAAAGTACAGGCAGAAAGAGTTTGAAACTTGAATAGCTCCCAGATTTCAGTCTTTTCCTGTTTTTGTTAACTTTGGGTTTAAAAAAAAAAGTCTGATTGGTTTTAATTGAAGGAAAGATTTGTACTACAGCTCTTTTGTTGTAAAGAGTTGTATTGTTCTTTTCCCCCAAAGTGGTTTCAGAAATATTTAAGGAGATGTAAGATCTTTACAAAAAGACACTTGATACTTGTTTTTCAAACCAGTATACAAGATAAGCTTCCAGGCTGCATAGAGGGAGGAGAGGGAAAATGTTTTGTAAGAAACCAATCAAGATAAAGGACAGTGAAGTAATCCGTACCTTGCGTTTTGTTTTGATTTAATAACATAACAAATAACCAACCCTTCCCTGAAAACCTCACATGCATACATACACATATATACACACACAAAAGAGAGTTAATCAACTGAAAGTGTTTCCTTCATTTCTGATATAGAATTGCAATTTTAACACACATAAAGGATAAACTTTTAGAAACTTATCTTACAAAGTGTATTTTATAAAATTAAAGAAAATAAAATTAAGAATGTTCT + >9<>:+069=,<:?98<<:(:<75299850<=8>;6<:919>>;3/49<63-777;<;'>>?>=?=8<9:=4<783<1=>:=?=??8?>9:;<9?6>>?1:<:>>>6<=<<)=>2/6>:17=4:8:1?>?;52?5;2=2669>::::=:>8=<36:>=8./.5?<9:7969;/6;>==4>:561;=>:=;7:6;=;2>?=>4??:==?>=?;=;::?=>>=:>?;9=:??=9>;4:9;.;<:=<>;9<86>>:=9=><;?>;6047<,8>?<98>>8;8:972:;=<+;=/<:<4:88:;98-;:*88>6===>+>>8:::?===;26749;6788<==>;>=9<>65:17;:?=;5:38:;6=>>=>3=<<:3+<0=974/-6:?49<(<<:=<:39>>;>5/=?8;9;;<>574=;<:;?7;<7;=;>9;;9?;>4=9:9:862@4:;9;A?>?,@;BCC@<9AC:;8<77@69;>>=>B1=?4>C2==3B@CBA:<,:C===6?=>;>,B@9AC<>@>+5@9C8A6>=,;7?6C?A5A=:@><@>?CA@4;A:;A9:4<<:18<;88CBA8@@@3BB6>?A.?;B1A=8@@C>?A699;<=BAB?5;><=AC>AA@?ABC@CCA?>>>?@6A6AA?A6?@<>A=8@C>?293;7>6:@9A=AC@:>6?>/91@>7AAAA;>;:6=A?@=?9=A7BAA+>>5@=88:2@?A=?=:@;B>:BC@4/>A>A;A=C;>?BBB:A?5;B>>A+;5=?+@;B@AC9A>CC?>A=>@:2=A?/A>8<>9CB8=AAC?:;?A=88B<>A7B=4BB;>:8BB9<@=>?@+>B=>5>==7AAB;>>AA;B=?BAA=A:A??.@?7?3@;?=@0=A?7>;BACA:;=@CC>C>=CA>@?<;=@A@AA86;:8>4A@>>>>>=B917=9:6BA85<6368>A-<,AB7-=?;@BAC@>@3:7??:A=>=3/@B?AA-5AB<=7>C@B@B?B7B=AC@;7>?A':A?5>@.20@7=>@6@7?:B??A:<<94>8BC?<>3?AA;/:B1;3>:=B;8;/?,=<=B>BCA0:>4>=9=:707@B*A5A8?>399->>6A=8<@@9>7CB:A=>8CB<=6?>@>/A<7?@A0C9?B;>A6>@CAA@=?A@:@;:6>8CA>A?2C=5:>44?:><;ABBB@>B8:0;?AA@@+=;4?=6;=@@A?,ABB8AA@9BA9;4;BA?>=@>B=<8189'7@<BA;BCA=@B@>@B;3B4@B;A@7>BA>@95BCB??B9C;3AA;?AAB>@:A:<>6>9=AABB>0A==BAAB>B@@B:=?>=CB?68;=A@<8<>?;A47<3B:<.C@B=@A;A5A=>B7?@;89@@<<8>;8:A>@=C?3?@@8@?=>A?;=:AB=B;B?A@<:=@69@CA0<:A4A?A=?6<:4@59A;BA6BCA>=<=6BABA>B@=?>CAAAB>B?7:CA??;=B7A<7BA?A9?>AA:>==B@A8<@B>?ABBB=:):=@5A>C@??C?C66;8>;59;4=A>BA>C@:B<@><==BA@,7)8:9?1@AB9B@@:==4>6=0@;2<@:=ACC:@CB1@==@72<<&>6AC>@>AB,AA?4:>?BCCA<;>A/=<;;=?BA@==B@C4;C@==@=ABA>;8C9B?>@>::?-><==B>?BA:@0BACCBC:B<<4C>>AAAB@AA>AAA0?>?%2?C5<:@-5A=>.=2=BA?@;BAB55A><>?@@AAA/@8<=>:@AB8AC;=:=1@B;CCC;C@2BABAA@+>?:@<>0?7A9A9?A6BAC;@66B8>@=+;8BAACC?;?>>?<8)96<==A0>A@/>98@<9==3<<;>=??>+@@>:6?81;=>9@;=B?==3?B:6>61B=@8?;;799?A:B=;=@+;4?@?<>@*56;4?<>>A=::>3B@@=-8>38A=??;:387=>=3=9665%7;<:99<<;$=989856/8/442'73;4==:?;=9998:<489;:<853*;:<>?;3<=4>;=:9;=:>:>=;<6=645:=>*+;91';?907:99=,;4<>>7=67;588;7897;85:5=;:8?=;482786((3>76?<<63;:66:9>:/)3<<5;89:9:>8>=>7<942.7;2=81:,1:3:82786:431800=;;<3>=>.9;9;5/73<6:6<8;7>38;::9>:;:.<1=>79,58373<5/<8;=9>8=5==3;88/7<=4-/.??9;66849=;;59;?=::*758*<>8<>;;89<;<74?;:99>;<99::><8==><;676=97=<=<:=><8;<&=>:7><.><96>>>9>??->=9=>9?>?9=79=,>;04>?;6<>:<.8<=49:91:2;92:240:>/91:;;=39=??794<9+9=8?;<>86>?==583<=:691=>1;;<<.;:==2>88658+8=<689 @rCer/1734/1687_42_CCS CTTTACAGAGCATGAGATCCAGGAATGGTAAAAGGCTTCTTGAGAGACTGCCCAGTGGACATTGTCAATGGAAGAGTTTAAGAAATATTGGGAACTTTTTCCTTATGGGGATGCTTCCAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGAACAATAGACTTAGGAATTCATCATCGCCCTGAGTGTAACTCCAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGATGGAATGGCTATATCAGCAAGGCAGAGATGCTAGAGATCGGCAGGCAATCTATAAGATGGTTTCTCCGTAATGAAATGCCTGAGATGAGTCAACCCAGAGAAGAACAGAAAAGATCTTCCGCCACGATGGACACCAATAGAGATGGAAACTCTCCCTGGAGGAGTTCATCGAGGGGCCAAAAAGCGACCGTCCATAGTGCGCCTCCTGCAGTGCGACCCGAGCAGGCCGGCCAGTTCTGAGCCCTGCACCCACCCATTGAATTGTAGCGCTTGTGTTCCCTTTTGATTCTTCTTTAACAATTTTTTTTTTTTTTGCCAACAATATCAATGGTGATGCGTCCCTGTGCGGTCTGATGCGCCTTCCTCCGTGACGCCTTCAGCTTCTTTTGTCGTGGATGCTTCGTGGAATGCCAGAGCCCAGTGTGCTTGTGGAGAGCATGGACAGACTTTGTGGTGTTCATTGTTTGACGGTTTAAGCGTTACTATATTTTTTTCTTTTGATTCTAGTCTCTGTTCTAAAACCTAAGACTCGGGGTGGGGAAAAGAAGGGAAACCCACCCAGTCCCGTGATTCTATGCAAGCTTCAAGGGCTTATTGTTTGAAAGACAAAACTCCCCGCCTGGGTCTGTTGTCATCGCGCTGTAAGGGTGATGGATGCAGCGGATGCTGATTCCCAAGAACAAGTTACCTCTGGGGTGAGGCTATCCAGGAGCTGGGACATTTCCCCATGGGGGCCCACTCCCCCTCTTCCCAGCAGGTTGTAGTTCTAAGCTGTGAACATTTCAGGTAAATTAATAGAGGAGAGGAAAAAGATGGCTCAGCTATTCTTTCACAGGTTTACACTAGTTGAGCTAATATGCGTGTCTTTGGAAATTAAACACAATGGTAACCTAGTTTCAAAACCAGACCCATCTGTTGCCTATTGTGATAAATAAAAAGACTGCTGTATATAACATATTGGGTATTGCAGACCAAATTAAGTGTTTTGCCTTGTTTAAATGAATGCAGTTTAGTGACACTAATACAATCTATTCCAGAAGACTGTTTTTGTAGCTATTGTGAAGTAAGACAACTATAATGAATGTCTATGTCTTGTTTTGAGTCATATCTGTCTTTGCACAAATGTACCAATCGACAAGTATATTTTATATATTCCATAAAAATACAAATAACCCTGACTAGGCCCACCTAATTTTGAATGCGTTTCCGAGTGCCGTGCCTAGAGGGCAGATGCAGACAGGTGTATGGGACAGGACAGTTGGAGCACAGCAATGTAACATGTATTACGGGAGCCAGGAGTGTGGTTGCCTCCCAGGCCCAGCAGCCCATTGACAGCATAGACGGCGGCATGGTGCTTTTCTGAGCAAGATCAATACCTGCAGACT + #%#"#&$$&%###$#*))-++,-.-**'&#&+(-),,&),(+++&*(,-*,,$*))---,&+#*-+.000*.++*000)/*.33&(%"+0500,04235*3$+/-*4--*()%((#+%-('($+-,.+)0/01,121.,-/./+0+,//'///+%(0*/+++1%''-,'+-%$%/$)'+,*0'/*',(*,-0/-,--+'++/+*%(&,/,01*,(*%(-'((+)+,%+-++,&$()+)+$'(,((&)%()))*+-,(*&''-)*#','(&%%&%),*-.,-))',-,+#$&),),-*+%(+--,,++$*--,,+&)+-,,+-&$-21/.0-+,++$,..-1)(/11111/1,'0+#&)&&,$,-',(+.'(&1/*'*-1,1-00&*(-/+0/-00-*)/**)*,.%),%+1---.-.21-1++'))+,(#'(-00&-%000/'++///**')$'(&$).101--20*++-*-*-+'*/%)++++$&*%2*1(&%-*,+**'&&'%++)(,&*,,(.($*,*,$*$'#!%('&'$),)12)*,0**#+'-,(((,$%%,/*(+-./000-)&&*#'(&&$/''+%*/,*)-&//*(-&+.)*%/.+//1(*,.0)*-010%1)-$,-%0--,,/2,0,/),,1,+/*+%(')(+)%*/11+(*/&+%&&.).)-,++1/'',/+$++.,+*'&)'(%%$*--/+%)0-*,(-+)*,,/-.-1,,/1',.0,(+-#!#+++0&),(&%'%&'*+*#*,)-*)&&'*$#(*00-++*+*%$)-$00/0)0.(+*)''##'(+%$,-((&%-,+,-),-'(,,('#$$(&)+%*)(*%)$+,-),,-*+,('#$&%"%%&$&&$%+-+*(((++''('+%#,,'&-.*%,--('%#')#"$%+,'+'%"'##$(%(-))*(+$&()+((+&&$'('*-$)(,-*-+))($$+$$('((*$'*))(%(&$,*(%#&%(((-*,*/,,)/+**,,+,,0%//*,-+/*/0',1(&11',,*/,&/'-),,+&'((%00+-+)001.-'',%%+.*-&.*.,-0&&0%+-&1.1111(.112/'-(,1/&+0',//'+-++.*1-$#*+/*/121,',,((&0-,+,.1.)+12*,',,*&&,+%''&($#/+.1*---),11)*+1-+,*-)-,'&*+(%./,)/,/)+)+&(,(-)"#,//*'.+*(-/'*'%()('%0-&&1/220-0/$+/'&+,%/0),*/)-,..++'--,1,+,.'#&&''*$),-$+--&*,-,#**,,-)+),$#)*$*-+-***--,-*,-,)+)"+'()'%,-(-(-.-,--&&'&-*+*+*'&+,-())'-,(,),,+%+,++%)#'$+(+*',--,+++&,,(,--(()&(-))%#(#'&(%(+(*++(%$&')($+%-*('--*-)(*,*+"(-+.,+'))+&+-&))$$+*#++*'&#$*$*+%+-*&'%%**&#)),(*+&,,)-*,),'))),-*)$)++)*#&#((+(+)'.(+)(,.,.+*-(,,(*-.,)%$%'$('-,(*'(,.-'#'-,-.,+%,,(.+(&,.)+,-&((*..,,*(,-..+,)$+$,--*'%%,,#,,-.+-,--)'+(+,,'%%%''+*$"%(,,'+)#'#))&(,*) @rCer/1735/25_1855_CCS ATGGGGCCCAGCCGAGCGGCCGCCGAGCGGGAGCGGGTGCGGGTGCGGGTGCGGGCGCACCGGCCATCACCGCGCGGCCGCGCAGCGGACACCGTGCTCACCGGCCTGCGGCGCCCCGCCACCGGGGCGGACCGCCGAACCCGAGGCCATGTCCCATGAAAAGAGTTTTTTTGGTGTCTGGGGACAACTATCCTCCCCCCAACCCTGGATATCCGGGGGGGCCCCAGCCACCCATGCCCCCCTATGCTCAGCCTCCCTACCCTGGGGCCCCTTACCCGCAGCCCCCTTTCCAGCCCTCACCCTACGGTCAGCCAGGGTACCCCCATGGCCCCAGCCCCTACCCCCAAGGGGGCTACCCACAGGGCCCCTACCCCCAAGGGGCCTACCCACAGGGCCCCTACCCACAAGAGGGCTACCCACAGGGCCCCTACCCCCAAGGGGGCTACCCCCAGGGGCCATATCCCCAGAGCCCCTTTCCCCCCAACCCCTATGGACAGCCACAGGCCTTCCCAGGACAAGACCCTGACTCACCCCAGCATGGAAACTACCAGGAGGAGGGTCCCCCATCCTACTATGACAACCAGGACTTCCCTGCCACCGACTGGGATGACAAGAGCATCCGACAGGCCTTCATCCGCAAGGTGTTCCTGGTGCTGACCCTGCAGCTGTCGGTGACCCTGTCCACGGTGTCTGTGTTCACTTTTGTTGGGGAGGTGAAGGGCTTTGTCCGGGAGAACGTCTGGACCTACTATGTCTCCTATGCTGTCTTCTTCATCTCCCTCATCGTCCTCAGCTGTTGTGGGGACTTCCGGCGAAAGCACCCCTGGAACCTTGTTGCACTGTCGGTCCTGACCGCCAGCCTGTCGTACATGGTGGGGGATGATCGCCAGCTTCTACAACACCGAGGCAGTCATCATGGCCGTGGGCATCACCACAGCCGTCTGCTTCACGGTCGTCATCTTCTCCATGCAGACCCGCTACGACTTCACCTCGTGCATGGGTGTGCTCCTGGTGAGCATGGTGGTGCTCTTCATCTTCGCCATCCTCTGCATCTTCATCCGGAACCGCATCCTGGAGATTGTGTACGCCTCGCTGGGCGCTCTGCTCTTCACCTGCTTCCTGGCAGTGGACACCCAGCTGCTGTTGGGGAACAAGCAGCTGTCCCTGAGCCCGGAAGAGTACGTGTTTGCCGCGCTGAACCTGTACACAGACATCATCAACATCTTCCTGTACATCCTCACCATCATTGGCCGCGCCAAGGAGTAGCCCAGCTCCAGCTCTCTGTGCCCGCTCAGGTGGCATGGCTGGCCTGGACCCTGCCCCTGGCACGGCAGTGCCAGCTGTCCTTCCCCTCTCTCTTGTCCCCAGGCACAGCCTGGGGCAGAGGACGCCCCTCTCCAACCCTCCCATATGTACACTGCAGATACTTCTGTTTGGACCCCCTGTGGCCACAGCATGGCCCCTTTAGTCCTCCCGCCCCGCCAAGGGGCAACAAGGCCACGTTTCTGTGCCACCTCCTGTCTACTCATTGTTGCATGAGCCCTGTCTGCCAGCCCACCCCAGGGACTGGGGGCAGCACCAGGTCCCGGGGAGAGGGATTGAGCCAAGAGGTGAGGGTGCACGTCTTCCCTCCTGTCCCAGCTCCCCAGCCTGGCGTAGAGCACCCCTCCCCCCCACCCTGGAGTGCTGCCCTCTGGGGACATGCGGAGTGGGGTCTTATCCCTGTGCTGAGCCCTGAGGGCAGAGAGGACGGCATGTTTCAGGGGAGGGGGCAGCCTTCCTCTCAATCTGCTGTCAGTGAAATTCCAATAAATGGGATTTGCTCTCTGC + I?9;CE9IICG:A8@BF:G8@BDIEDEG:E@@HF&A17DDCGGEKI=C=IHHDJA?EFHIJKH@HJEIFJGGG@BCJ54B?A+A88E>HIGGIJH=KBHKH?I=KCBEFB>>38B8BGD5:E;FEIIIK+IKKIIDFCKKHBG1C?>>C@AF;@.?FD)BECFD7=>GE5CF;BIFFI.GHF<9BB:II@@GKI?IDGEH6FFGHCG3ADFJIKJGKD=GFC/8H@HBKCJ-GCCGI1GKHEGFF(=AD@8BG>H?HEGJ=GB5CFE6HIDFHHC@CE@GIIJ9G=>AC??G7GFJJI3JCHHI:GIKIG@0AGGHJCCIK5HEB>.1G>A;7B1@CFCAAHI5JKD66-;26<J=E0@?A6E93FHFGE:H5BBB<;E=F9ID@7?HDG;<888@>KGA7E2A>HHK@C@G?;FG?E5>ICFJFHFDH>IHI5=EKF?HD9>C;CI65?;=4CH?HE>D@9GJHJGGDFDJBHIGK@HD?A@HG:?AA6:48A@?F?@;FEGD,E?@8AB3CH@=EGC=;E?IF7BBKJE@H/>3=BBGHB4E@GKIBEH:C;9FFE1CEHHIEECB@GBA@:7IFJE>JAHC8GJI>GJGKHEHHH?GEDGD4BKEIE:GFFCJGJDKKJKD6KFI>EH@C:KGKC?FGGAB2@EDDIG9CGIG?HH0AIE>KIGEE@@CHFG8A?%CB:3=DDCJGJHIKKH4F@8E>:IEJHKDHEH>CKGACKIIJBICHHDCEKKJKHD:D7ED<7AJGGG<57@8DEJFJBAHCCH>8G3GCI:K6=IEDJ@E@E?G>IHGC;JBKFJ4FCKG?>KBFJHEIDKGFJ@6EG:BDHF>>EAIGI9FBDGDIH@FGH5?GIGBAHH3=D;@FBE2HKFHCHCBGJJ,G0?GKIGFFJHJ95)EJ5G>=BHKIF?JHJDKIJJGF8FJIBFI=IIEAC>5(6AHJD=BKJIIHHIKIHFEGKIBKIJJ2HKKICKIFI>KKDIDKBKGKKJKGGKKK0KKKJIHIKJCIKH0JJIHKKJHGIIB>@7BAIFFIGGJ;KJKKJKJJKHKGJIJ?7HFKHKKK?KKJGKJIG;@JJ8KEDHDKEJ9A;KKDKKGKGJDGIIG2D=@CJGKGJIKKIF=KKHJEKIJJKGJ=KHJ7@B@B>JJGEJ*HIKJ>?EIJIKFDKEFAGJKJKKHJJG;C7HJ;HI86F;FIE>>K@JFE>FEKBECKKC9>2H@EIGIJJHHIF<9FIIAK8;JIC:GAJKJDKBHD@EKDJJKKCH9IAFGI3KKA9EA9>86<;?B/FBDIE;??CD7;CKI8HGBJFKGEAAG>KK)EACA/CKFEEFBI7H;76A5:9=?=GGDHIDJHD8JJIJBC9FG>:E<35=9:45';:79=:>?:<<22:>>7497858;3,;:9355<8,<5881689579792-99743566..2*4'--1*4/6,3.+)0200-,/32*0./,22,2241.)00//036456*0,+2*)/5465/0341*66)//(&.$01-/)--.131643/031332063+,5,00.*112*//0..)(3$%&*)+00/.(0.*01*..///5/55*$%&)0.*404%0420(/.)-+.5.3+/,)+(.124/*.,//)-)(*1.230.%-.'##&*.)+,,1.06525000645./4/10*255432*44402133001-40+$-)11.'-%,(-+-/.*)'),,-00+1520),&3*'.,,+,(&./-,.#(*'&$*+*)-)+/(-'-*-..$/0/.'//0)/*/2/(10*/*',*+(2+(&)-4)34,//-4-335).0*1,*#4)2.11134/5/2,3%.,)%/1032*+,10'..(/1-*0+)%0-&/*/14-,-2500144-%'.(+...5,1.2./41(.-1-//*(#),4510,6/)-426)3)2-)),/&'(,(/-/,+012&3-(1/'551,/)/,)/3.-15-3+4125/-+*-*,1+,4,)--10(.0-+%.45.2,+-+-00)2/4%0-../0&$2101222-*.(,536)#.,(*%')*,-110/*/.-46/20'1,&.2,/-/41510 @rCer/1738/0_1608_CCS AAGCATCACGCAGAGACATGAGGAGTCCCAGGCTCCCACAAGGAAAATTAGGGACCTATTTGGATGGATCCGAAGAACACTGTCTGGTCATCTGATTTGAACGAGGCCGCCGCAGCTGGGCCTTTTCGCAAAGTAGGCCCACTGCAGACCTTGGAACCTCCGGGATGCCTGGACCCGCATCTGCCGCTACCGCATTTCCTATCCCGACCTCCTGCAGTTGTCGACCCCAGCCTGACTTTGAGGTGGGTCCCGCAAACCCTGGCACCGAGGGGCCGAAGCCGAGCGATCTTGGGTAGAAGAGTGGTCCTATAGAGCTGCCGCTTCGGGAAGCCACCAGTCGACGCTGATGGGGAATGGGGGATTTTACTGTTTAGTGCAGCCCGCCCCCGGAAAGGCGGGCTCGGACGTTTCTTGACTTTAGGATAGACTGGGAGGGGCGCGAGGAGCATTCCTCCTTTACGTCTCGCGTCGCAGACTGTATTTGCCGGTGCCCTGCTCACTGGGAAATGGCAGGACCTTGGGACTTACGGAGACGACAGGGCCTATTTGAGTTTCTCTGATCCTTAGGGAAATGAGTGTCTAGAGCGAAAATAGTGCAGAGTGCCGGCACTGGATTCTTTAAACCTGGATTCAAATTCGACTCCACCACTCTCAGTGAGGACTTAGGCAATTTATTTTTTAACTTCTTCAAGCCTCTGTTTACTCGTTTATGTAAGTCAGGCTAATAACGTAGTGCCTATTTCATAGGGTGCATTGACTATTAAGTGTGAGAGTGCATGTAAGAACAGTCTAAGGGCATTTCCCTGCCTTTCCCCTTGTCTGCTGTCAACCTCATCCAAGTCAGACAAATGGAATTAATTAACCAACTTCCGCTTTTCTGAAGCACGGGTGAAGAAGAGTGAAGTACAGGACTTGGGTAAAGGAAAGACCAAGAAGGATACAAAGATGGATGGATGACAGAGGTGCTCATCCCAGCACTTTCCCTCACTTGTCGCTGTCACATGGTGGGTGCTTGATAAGTACTTGGGTGAATGAGGACCTACCTAAGGAGAAGGAATTATGAATAAGACTAGAATTGAAGGAAGAGGATGAATCAGATTGATTAGCTACTTGACAAAAAAAGGCAAACACTTTCCTGTCAGAAATGTTATGGCACATCTGCATATTTCAAGGCTACCACTTACTAGAACTGGGAGGGAGATCTCAGAACCGACACCTCACTATGGAAGCTTTAATCTATTGACAGCAAATGTAACAATAGCAAGTAATATAAGACAGAATGTGATCAGTGCAAATCGAATAATAAAGTCTGAGAGGGGGTTATTAGAATAATAGACGAGTGTTTAGATTGAGTAGTGAGCAATGAGATAAGTCCTTTGACTTGGGTACAGGGGAATGTGACCAGGGTATGGGATAGGGAGAAGTTATTCTGGAAGGCAATAAAAGGCAGACTGATGCTAGTGGTATAAAAAAAGGAAAACACTGTTATCAATGTCTATCAACGGGGAAGAATTACATATGACATATGCTATTGAGGAATACCTTCAACCGTTAAAATGATAAAGATCAGTGACAAAGGAGTGCAGAACAATATATATTCCATTTTGT + """!""""$$$#$%!#%%$#""$#"!"$%$"$"#$%%$$!"""#%%%&(&%(((%%$%$'&')####%$#((')'%(''($%'(%')#((((%()())(')'%##%%$%%%&((((%')'#(#'%%('%$$('$$#%"'((($$'#'(%&&$%(%%%$#&)&))%##"&&"$%())'%'#"$$%''$$%##('#')(()$#$&())'##&&$%'$'$$(((%%(%((&%'%$"$*%#$++*$$&"##$)-.+-,-.)+'(*.,'$&),&(+)*-#),,,.*-,*-,+$*,&')(&)(++*+&%*(*,,&+,--+..1121'*/*+00)&0'/0-1,&,1./&*0(-*+#++-+.0*./0,,%,+,.&,,%-/*,1.,,.-221)110*%*'%/*1.*201.0%.-0/$(,.(./+*&*)+021,)0/%*'*0&(/--0)&-,/./*,-.1&+,&/.22**0--/-.-+0/10$&/1++,&#),-%,).),%)(01/&+&,+.22%,'%$++,./)-100(%++/)/--(/,..111,""'((--.'10.'0',&(+-+/.0))&(%,02.221,%,*1)%*(+,&+-'+%'+&%&-.10(11,*,'&')+--,&'//%--#+0$.'$,+%,1+),&'&",-0*/2/2/(&&$#'*,1%,2/)).+$,//2-12'*03542.1**1+-5/)1204,-.)(,214034+.*,120%0023*)--,,0'(221'/'$&(0**&/-,*(0'/(&%-#&./.1(1-.12101--.--*,0+*(+,/21121--*'+*++.10'%'+&/.))*.((,%,,0,11-+$)'...1&+$$,/--,1'0*.1/$+,(.10-/)/%-'/,00212,1+&+,0,0)000/%%*00..0%-(*$)-+*,)/11..10'.0*+-*0,1',0.&0-$+,0--1-1'1-,2-+.(-+$10,,-.1.,%./--.-111-10'/('(&$,',,/-/)0/)$,*/'++0+,.*#,--01-10(0/'0+&)*,00*+'0%*+.).&/0+/(,,'+,0&.2,0*0102&,)(-2+200*1-+/*/%%./+/&----)..)0&,*1/+&+,/)&0.1'01&+*)*/+-10,.+-+//&/.++//&,,,2/&/0%.,+2--0*0.1221.&$&,&/,.10.10--)*/'*,..0&*()+&--1*1)),--0.1-'-*-'/)(0,,111,-*,-.&,,0-0-+'),0&020201&/-,..0'1-10+0.1.,,0,/./0+'****0.1/)*1,.,','*-.1,1++//,&)*+)*/$/-')-*(1-10&/.//.$((./&)*//02/+/,+&.*$-/0/,.+'-&)+,0-0.*.-1/-1./')(,&//,+(,,'0+,*-(,-/'+%))/+'(/-&/-+)*$*//)'1+'--((%"&)$*+**/1--,%+10,-1,(/02&*0021(0/.)00.1**)%)+&+)/.,)-%&+%$--+&'%(#,..01/*,$)*'+12,+*,/.%,+--%+,-,10-1-1.-)--0-,1/&+++/'./2+%(.+1),'&&..+.',-$)'0-,'--,%-##*)/'-1111+.-&#",0)&+)(,-+1(*+,.0,**20$-+/(& @rCer/1743/25_2027_CCS ATGGGGCGGCCCGGAAGCGGCAGCAGCGGCGCGGAGACTGCGGGCGGGCCATGGCGGCGAACCTGAGCCGGAACGGGCCAGCGCTGCAGGAGGCCTACGTGCGGGTGGTCACCGAGAAGTCCCCGACCGACTGGGCTCTCTTTACCTATGAAGCAACAGCAACGACATCCGTGTGGCTGGCACAGGGGAGGGTGGCCTGGAGGAGATGGTGGAGGAGCTCAACAGCGGAAGGTGATGTATGCCTTCTGCAGAGTGAAGGACCCCAACTCCGGACTGCCCAAATTTGTCCTCAATCAACTGGACAGGCGAGGGTGTGAACGATGTGCGGAAGGGAGCCTGCGCCAGCCACGTCAGCACCATGGCCAACTTCCTGAAGGGGGCCCACGTGACCATCAATGCACGGGCCGAGGAGGATGTGGAGCCTGAGTGCATCATGGAGAAGGTGGCCAAGGCTTCAGGTGCCAACTACAGCTTTCACAAGGAGAGTGGCCGCTTCCAGGACGCGGGGCCCCAGGCCCCAGTGGGCTCTGTGTACCAGAAGACCAATGCTGTGTCTGAGATTAAAAGGGTTGGTAAAGACAGCTTCTGGGCCAAAGCAGAGAAGGAGGAGGAGAACCGTCGGCTGGAGGAAAAAGCGGCGGGCTGAGGAGGCGCAGCGGCAGCTGGAGCAGGAGCGCCGGGAGCGTGAGCTGCGTGAGGCTGCGCGCCGGGAGCAGCGCTATCAGGAGCAGCGTGGCGAGGCCAGCCCCCAGAGCAGGACGTGGGAGGAGCAGCAGCAAAGAAGTGGTTTCAAGGAACCGAGATGAGCAGGAGTCTGCCATGCACCCGAGGGAGATTTCAGCAGAAGGAGAGGGCCATGTCCACCACCTCCGTCTCCAGTCCTCAGCCGGGCAAGCTGAGGAGCCCCTTCCTGCAGAAGCAGCTCACCCAACCAGAGACCCACTTTGGCAGAGAGCCAGCTGCCACTGTCTCAAGGCCTAGGACAGATCTCCCTGGTGAGGAGCCGGCGCCCAGCACTCCTCCATGTCTGCTGCAGGCAGAAGAGGAGGCTGTGTATGAGGGACCCCCGGAGCAGGAGACCTTCTACGAGGAGCCCCCACTGGTGCAGCAGCAAGGTGCCGGCTCTGAGCACATTGATTACCACATTCAGGGCCAGGGGCTCAGTGGGCAAGGGCTCTGTGCCCGTGCCCTGTACGACTACCAGGCAGCCGACGACACAGAGATCTCCTTTGACCCCGAGAACCTCATCACAGGCATCGAGGTGATCGACGAAGGCTGGTGGCGTGGCTATGGGCCGGATGGCCATTTTGGCATGTTCCCTGCCAACTACGTGGAGCTCATTGAGTGAGGCTGAGGGCACATCTTGCCCTTCCCTGCTCAGACGTGGCTTTCTTCTTGCTGGAAGAGGAGGCCTGGGAGTTGAACATTCGGCACTCTTCCAGGAATGGGACCCCCAGTGAGGATGAGGCCTTAGGGCTCCCTCTGACTTGGCAGACTCAGCCTGTCACCCCAAATGCAGCAATGGCCTGGTGATTCCCAAACATCCTTCCTGCATCCCCCTGACCCTCCCACACAGCTTGGCTCTTGCCCCTGACAGGATACTGAGCCAAGCCCTGCCTGTGGCCAAGCCCTGAGTGGCCACTGCCAAGCTGTGGGGAAGGGTCCTGAGCAGGGGCATCTGGGAGGCTCCGGCTGCCTTCTGCATTTATTTGCCTTTTTTCTTTTTCTCTTGCTTCTAAGGGGTGGTGGCCACCACTGTTTAGAATGACCCTTGGGAACAGTGAACGTAGAGAATTGTTTTTAGCGGAGTTTGTGACCAAAGTCAGAGTGGATCATGGTGGTTTGGCAGCAGGGAAGTTGTCTTGTCGGAGCCTGCTCTGTGCTCCCACTCCATTTCTCTGTCCCTCTGCCTGGGCTATGGGAAGTGGGGATGCGGATGGTCAAGCTTCCACCCTGGGTATTCGAAAACAGCAGACACAACATGTTCCTCCACATGGCTCAC 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99+:7975:-72783978082-.234-,6596.87175337*292.699;763885.73.2292633/546277(89865358103:-17-+/1672227)0*122$32)57512/.158)3756//78385.:427925/493546693$.$4038-881815495236037/4779689785'(05595771:03:3:9:;74-73186;4396127:1868:<-878<><=705467<59/;9.4.6;33=9;=18-7<;?/:2++426561:3;98660:>831353&322)46.(7252,+-/6(823,760;9>6.<8973:8=-683=<529729:6<70<77;8-<9>2=+303470:90=5;887=(;;:1+69:1/617781+23>:><:5.6-&>68.33=:<79;,<8/-6=<<<07:9:825(;32)/+87:?891888=79<46:66=&03(03.*75-9>=56?6:=<:<62?849:28796';;9=0>6=-82>9:6;4,447*7:92,7176;'220;-71/;8.29=:8:>://992=3>;73'/78597?949:(14<9<<<3-72:2:<895=&:9979;573+43,)0=<=6367<404:6;;8<:1356=>96?758493)5367:>8845:8737:-75=8;9:897=98=;1<:;679,:.-:,2/10441-+,046+/0568&70;;;><:98878<1266%8;414.3314;=@@$2,27@::-<+7785;:C1>;?<>85>7:5?>=5;//51;7:3,6.3'7:5;.=64/9%9=9%8;@@=C@C=8)6;<;;'&347B<=A5/;=?8:7=9>A>?B<5?5;>417<775<39:;2@<8697=:?A6,4537?<<>@=47>:>:;?:7/87@?>:,B>-<@<=2=><=:@?7CA4?9:?89C<9>@=>A>?@BB=A>=A@5>3;:939<>?66>>B9=>;A@@;B>?A7:?99.682@>6;:=A2A@A2C=AA=>>=A;>B>:B9:B@B:B=28>9BA@=;A9;=A@>5<==>C==B-?::A@6@=C?C>*<<;:@A@BB2<;6:=6@A@@6=A=><8::@A36<306;85<=?A:CAB@?:==B982699;:2:6:?;5(56545;,:'5?8119:8>+308:;:7677:4386;<437<@6<6<8386598:3254%857=/9/=7=1:7517:===38;=<3<9<72=4<;<=7<;119357=?<;6?;;@62<850:6:;45:8978C?@CABA68,)877@B/<=8;??;9797:?<7>85B<4@A>8.=::?:6;6GC:AA>.GBCE@BAFFB@:3>97C@E@=84BDDE-BAFAA@5@1>8DCCFD3<>;?4=CEA==(<56,9CEF>A>B3E<;@FC@)@CEG?B;B>DD?@.DEDA4@A6EBC5@EFAD9AD?-<1@?CE;?;57;B;=E4>>@C9D7;95A(C7G@/D?;E:=C@G6E@C?C5B>G5B>D@5A@;<>9>A9.1?FC@DF=G@B@BED=(CECEEB;:B4?A;@9@.?;@FBGGGG=?D4=DDDF4?@A4>==79E=:B:?A@EDFFF9EE:D3@5@D>@B5A+=<=A<58CBEGEB>@>CD>C>F@(CACEADC;E=B:BBAA?;9?5=DA>E>CA?>?=BDD?:7@:9E4AA?E=ECGF?:E@CAC?78297EA>?D+B>8:?D:B4A987A;B;,=?>0668A@D><'BDCBEADEA?9@A2?<:BECC<6<=8:=9;<37.72>5;=<55>><89<:<;8<;;9/86;25769;?8:=:=;89<<7;-=?8267;979=59664=9;>>;;7>18.?9?6=5.7;>:9<705.98-199;7796$,679:;=296:6=?<6885>5577:62<5;9/9714<6:497(2577'48:89383=<;86:%<6:?<:=:=7=:><<3:===;:7528;54268>;4;:868?=9><5=6:7;<+7?08;718=9=82<:8=4;;<92.5=5:51/8;=5=8927;:;=75<.9;4:1617;5<:;:;<.>88:38.37<:;=796::84:3/217,=<:8;);:=7/67889.=>;89>416=<98>:998<9661=7947:%70451?8=:<:;9;::96(;5:;9<4;02;;.551&6-60984=:7=73;9%:<>;6991<702858.8??9;=<9;;>?;9;:4+8<<1<69<>;9;0>7;24$,;==):$4=;4;>;=3=;4<959=99450><99;;47.<<(687&:9=<08?;8;;;::?:8?<9;=935=8=;;:5=8=;=>1><:=58:-2=;876:18:<>;>3;80<=91<2=?7=6=88456,18033<34>2<;>0=98=:=6>>?<<;9:><9=?<29:9='2;<0;=96>5+===397=:';7;;->=33:;;7?8:481896<79:92-469::45413;:6:754+4623(51556695:996319:95860/34878/99:;9:8565:454;55;9507&1884/258699753879;7:8.753;7/::9;6:8:6438659:6::994/98:858::;6:::9:965665;44/4:83::1::;763489:;7298439768;65:85:686+67346:8856:9:78947::/6949;6858.775496/6/946799;54685.8::12-.5'9:147897+).4928*6487)28+9::2:344..3#133+2669910:89114956825/89.68.:955449995999;59898884:3-69:944947878;85:5;:77':9040,8866:3:2.358795769122*2.4,43/5547:69::4.756982743617'99689653.6978266945.82987:6:6:9044012,6:999+99:;:447::99;;695:667059:8187+83/72;37585/168:56&7,6967579:.88:97;;;8661+566298905.(84:489799,79:070:8845479)8401-::::6/92*57;:,976621972647021863114%65-76224739088297226:049436.:23:3663652 @rCer/1751/25_2290_CCS ATGGGAGTGCCGGGCCTCCCAAGATGGCGGTGTGCATCGCGGTGATCGCCAAGGAGAATTACCCCCTCTACATTCGCAGCACCCCCACGGAGAACGAGCTGAAGTTCCACTACATGGTGCACACATCTCTGGACGTGGGTGGATGAGAAGATCTCCGCAATGGGAAGGCCCTGGTTGACCAGAGGGAGCTGTACCTGGGCCTGCTCTACCCCACGGAGGACTACAAGGTGTACGGCTACGTCACCCAATTCCAAGGTGAAGTTTGTCATGGTGGTGGATTCCTCCAACACGGCCCTTCGAGACAACGAAATTCGCAGCATGTTCCGGAAGCTACACAACTCCTACACAGACGTGATGTGCAACCCTTCTACAACCCGGGGGACCGCATCCAGTCCAGGGCCTTTGATAACATGGTGACGTCCATGATGATACAGGTGTGCTGAATGAGCTGTGCTGCCGGCCATCGCAGAGGATCCCACGCGTAACCGTGGTGGCCGTCAGTCTGTTCTCGTCACCTCTTCCTGAGTGGGACGCCCGGGGCTTTCAGGGCAGGCAGCTGTGCATGTTCTCTCAACTAAAGGTCTTGTGAGATGAGATTTGGCTTTTTCCTTCTGTGTCAGCCAAGGATTTAACTAAGAAGAATTCAACTAAGGACTTTCAGTGGTGTGGGCAGAGGTTTGGGATTAGATGGTGCAGGAAAGCCTGTCCCCAGTTGTCCCAAGGGGCAGAGGCAGGGGCGCCTGGAGCCAAGAGTTCCTGAGCCTGCAGGACCTGTGACCATGTGGGTCACCCATTGGCTGAACAGGTGGACTGGTCTGGAGGGGGCGGCTTCCTGAGCCCAGAGCCAGCCTAGGATCTAGGGGCAAAAGGGGAGCCAGCGTGCCTTCCCACAGGGGAGGGCCCTCCTCTTTCTGGACTTGGCCTCCATTCTTTGCATCTGGCCCAACGTCTAGACTCAGCCTGGCCTGAAAAGAACGCTTGTGAAACCTGGGAAGCCTCGTGGCCCCGTGGCGTTGGCTCAGCTGCAGCCCTCATCCTAAGCCCTGGAGCGCAGACTTGAGGCGCCCCTTCCTGCCTGTTTGTGCTGAGGGGGTTCGGTGCCGTGTCGCTTGATGACATGACTGACTACCACCCAGGGCAGCCGCCGAGCCCTTAGTGGTGTCAGTGCCGCTGGCAACCTTGGGGTCCAGCAGTCGAGGCTCAGCCAGCTGAGGAGACCCCCCCGCAGAGCTGGTTCCAGCACTGGTCCAGGACTGGAGAGTTTCTCAAGGACCTTGAAGACCCCAGGAGCCCCTGCAGCAGGAAAGGCTGTAAGGGGGTCAGCCTGGGGCAGACACAGGGAGGGGAACTTTCTTGATACATATTTGCCTTTTCATCCCATCCAGCAAGCACAGTGTTAATTTTATAAATTATAGAAGAAGAAATGAGCAAGGAGTGTGTGTGAAAACCGCAGGCTTCCCTCGCCCAGGGTGAATTGGAAGTCCTGGCGTGGGCCGAGGCACACCGGGCAGCTGGTCTGAGTGCGTTTGGGCCACAGGCCACCCTCACAGGGTTAAATCTTTAACAAGAGCCTCATGTTTGTTAGAAAGTGGGACCCCAGCCCAAGCACCTAGCACCCTCCCCACTGCAGCCCAGTGTGAAATCTTTGCCTTTTAGTGGGGATCGCTCCTGCCTGAGTCCTGGCTGTGGTGGGGACTCGGGAAGTTGCTAACCCAGCATCCATTCTCCTTCCTCCCTACTAACAGAACTCTAGTGCCTCTGCACAGCTCTGACAGTGGGCAGATGAGAACCATGTCCTGGCCTCCCTCGCAGCCTGGGGTGTGCAGCCGTTGGCATGGAGGTGGTGGTGCTAGGACAGACTTGCAGGGAAGCTCCTGTGGAAGGGGGCTCAGCTGCCACGTGCAGGGCCCTTCCCTTTGCCTTCTTCCTGCCTGGAACATGGATGTGATGGCTGGTGCTGGCACAGCTGTCCTGAGAGAGCATGAGGAAAGAGTCACACCCTGAGGACAGTGGAGCTGATGCACAACGCAGGAAGGAGGACCCTGTGCCTTTGCTGACACAGAATGCGGGAAGGACCTGTGACCTTGCTGAGGCAGAATGTGGGAAGGACCCTGTGCCTTTGCTGACACAGAACGTGGGAAGGACCTGGGCCTTTGCTAACATAGAACGCGGGAAGGGACCCTAGGCCTTTGCTGACGTACCAGCCCCGGACTACTTAATTTCAGCTTTTTTTAAATGTGAGAAAATAAACGCACCCTCTCTGGT + -32,-3./1-0(/0/,/'11/-.4+&-+//-.01+/-2.1'..0-0-,-+'..,2(08+68'811214021)/035169+0%.001013.60083463-8820.-6195+337**)-00/,/133+-,,(085141&++,+3.),120)3,/30,-43.7/'65.1,2398576,80-0*0+1.01+'//80*014%40&08601/*$,,+119.6,2;0,2//1951034,..814963778%3,*3*-/515/023435266520+3453++034.468798939853415743433/966(637146*103769,*110),+30+42251222(..3*16412/1436202+1()1625$-).4951.'2'44((/,-/2453/03504%+56*2)(5&011.2-==9+2:77;;-0,/,1.413684302=8=130:..1;54-327:566-88534785/873.23883-8>6:94;+*628;1/766=53;11/,)/03)7(13386207763158=78545=5*42*01&15893;1150:;25'./022/)1673.2.051*-22;/4'9:(4,55;86;825;527:.83566/::6:292669821.238596=3723286=132;18=53;-;=5/6;;<8>34+)2%+6822139*;:81.144.09/;81-6<:9-3<935;:;&6-+64;9/+7;5;8,:2(.95+;(:7*/992414408:=<>8<915$07:3:+59.><8;9<:.694148=3/9239:83<8:24/125630-7:16.2449,9=>:39:41,3/6148.;17:855>+18181><8:4-9563:8.:<<,4/./987;,.*046274:=.<77959;<2/4771=8914:57;,79:1.69/:;6:76721/16297937-6087.73.:5+256.86+(%2(264:9>4;;140:47412:75<6939+989;267;911+.5(8874:+4.'//'1,+4/0.%5465,053622472/67<79767034833,4577442&5815;34670598<5?:>;7=2)023,3.::4,386,89-3/86./*/1.,),/6?7901/767'3+).5++/.63-/0)')0+*002'*0'*()'15*/6307946)832?::)0=5;76:;-/''.40/.3116513$;4808=<;::54<7235856:899/26-8:-1843'587242.598=>92/6'+/34/:651585-;-.426,'1/.23034)343631$%.+.;7<59/757-1911(63258;1356/;%555;94-338&/096-6:24>6%/1*-/44414-+361.1+2173*;56-54.23..6-,8688?+::65*2-0316'-/,-(-,5/68'4644-6%5<7/4+6639/758:963<;27652:57/2,1-(.1172433*2592=<577;/+0$39(11%./93446901(3+662..320)589/)54/56434/27788(04100,)21,2-.49/432/37271-2'*576+0+*)2.+**+(/0(40+025*43.5+'1112(1/+..3.--0'(*$'-.2+-2,,-1201.+43/568-&254732$,01,01)420/871283862/20/124:819634&/32/23049:347,,,63*32062198618340-6)00618434146437+3,.57/,%1&0-,5692*14032.001:79-*0-..26345569756502448/10,++'14045-1302044,,646597356421+0,)28'/26;240(,.124227.8448.536.,45,%"+)(,.'+'*+2/4237/.7/.0&,+0-0211',51+4(5526-2),02/1%/31%55533(+*2+'.13671,*-1130&2*'(#(/-545/747401/26/36.27,71,//55292234*54/-/0,2039220316-4)'34,'$10)/.3.136;,353.3,+*2+((1325302436:39)34052523/1+-*$/5/13702-.87&/4685149*555+/,3314503:::-26988&/)1776561058:771)%/2141)3+03.10,503316453),-.'2.1/6136664/55501-21..*.++,1(+)'0-010.1.62*0*))2.01+12+4%,+1051'/(114.%2131,20*,0--+11./2/242+03./25.135,/0(4.1.,'$41*((11*/41*,)54(/23'/41-(2+14' @rCer/1753/25_1818_CCS ATGGGGGTGTTCGGCATTCTTCTCGTCTCTCGAGCGCACGTCTGCGGTAGGCTCCCTGGTTGTCCGAATCACCGACCTCTCTTCCCAGCTGTATTTCCAAAATGTCGCTTTCTAATAAGCTGACGCTGGACAAGCTGGATGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACTTAGGCCGGCCTGATGGTGTCCCTATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAGTCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTAGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGGATGTCTACGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGAGGATTTTTGATGAAGAAGGAGCTGAACTACTTTGCCAAGGCCTTGGAGAGCCCAGAGCGACCTTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGTTGATCAATAATATGCTGGACAAAGTCAACTAGATGATTATTGGTGGCGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGTTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCAGGGAACCAAAGCCCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGAGCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCTTTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCAACTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGGTTCAGCTAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTTACTGCACCCTGGATTTGCCTACATTCTTCAAGATCCCATTTGAATTTCTTAGTGACTAAACATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAACCAAGTGAGCTGTGTTAGCTTAGTTCTCTTTTGATATAGGCTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTCCATTTGTAGGTAGGGAGACAAAATTGATAATCCATTAAATAAACAATAAAAGTGTCCACTGAAACCGT + .76B=@?.B@7C@>ABD@FDCE5,,AAC1?>91=;46DDF8E;D2A)@;AEBAFE>:@@>FCDB>HCADH>BCCIHGHHHGGDFGGAHG7FAGI3BB8IEE8E@@BA==EHBHHCCFFHHHFII6C@A=I>CB?DEEIIDHDDC:FF4@BB7DCABC4@JEDGAB=BI@>DAF<:A@9>AE?CCE7A@<5@BBDFE.E8AEGD@?2<.09?DDH8H:G@CBHA/AF1CA7CFCEJDGADB;FCED>>8E=>B?BFAGF>GGEHA:8@8)CEF>@?>=B8=1G3CFAGE@HG?@GFGFADH5FGEB>?@E5BDBBD.A2ADDB@F@?E<>>A?D7F@FGEE:JHDI/GH@JAHE=G;+?9DD.BC7FE9D+<);54>69=<>;8F;@1>4:E@EFHAI>B9JD6A?AEE??D45CA;9BHFHDGEAFFFHE=@A=B25AA=ADF>>DBCCG=GDCF5FAEFFIAEGJECBJ>E:GCC@B.>6C4C8CB<>@9.@@4AEDCB7@D0B>EF?<:C:HF:FDAHG:HI?ED)E55FJ8<6C1=@;/@ACC?ADGF4DBBD>=EF?A=:1-:CF??B?ACEBHCIGC6H>??@:C?8>;;;6D@,@<@A:BD5CGGE@GFG@G=H>GBECADCECIG;CHD>AA@EEDBBIGA9?>@C=5=,;;B?@A<>??4:A>=6G-4=C1EH>E>CEDADGE?HE+>=2GFCDGG.=:5EC@5>7:00=CBBB;DBB?2@8?CEDHFCE<>=?==8A9=DDDE@C7@DA:EDIH>ADBE>BD57*75A63@A>3EBFFH=?C%;?=BBF:;A->@>E=?C?E9=CCB@C>;A=6@/<@DC28@II6J3DEGGJ-?EEB@CHDCBB??BDB<<<>B3EBAFE.HC<8.A?BA?;-8AAE@>>HFCHGDC@/CI@AAFFAGH=J/DC;?@?E@A5JD>EG;G7FEFG?FEIDICJG?D@D9>DEG-IB=BCABIDC4CA958=/BF@C>GHED84B=FBC@C@?@;B>9BGEE8CD=ECC@DA;;-;=B1:EH?<@EB5@@?DDFC?>G<->DC:<+AE5,>8CCEC9@,EG?@EIBE?CDEEC@AG:GDDA=2304;@7;;6@AB@HFHD6?=C?3C:A>;5D???F5FIFAD=@:B>GC=?@EFBG;F;<588<0A;>=;>=5B>AEB;C>=>;8:68B<;5=A3EGD2AA;><733362@?DDE:GAB;6=5<@951:>=@==;@?CC6B?? @rCer/1756/144_49_CCS TGAGAAAGGAGAATCGCTGACCCAGGAAGCAGAGTTGCAGTGAGCTGAGATTGCGAGATGCGCCCCAGCCTGAGCAACAAGAGCAAAACTCCATC + #$(&$&$'$'#)&($%'%$$&(%()((%(((%&#(&%())())))()))))()-*%**$+----,)--,)-)'+,)'$)%)((,'&((),.+',) @rCer/1757/25_2202_CCS ATGGGATGATCCCCTGGGGAGGTAGCAGGGACCTCTGCAACTATGCACGATCTCTCAAACTTCAAGATTCATGTCTGGATGTGTTATGCTGTGGACATAAGTTTAGTAGGGCAGTCACTTCCTACTCTGAGTTACTGGTTACCTAGCCACTCCATGGGTATGACTTGGTCATTAAGCCAGTTCACTACCTGCCTCCCACCCTGGGGTCAGGACTGAACTATAGAAGAGCATCATGGCTGTGCAGGAGGCTATGGTTTTGAAAACTGAGCCCAGAGGGCACTTTCAGCTGCCCCAATAATGTGAATGGATTAGTGCTAGGAGCCAAGGAGCAGGACTGGATTATCTCATCTGACTGTGTGCAGAGTCCTGTTGAATGTCCCTGTTTCTTTGGTTGGGTAGTCAGAGCTCTGCTATGGTGAACATCCAGACTGTCACCACCTTCTCTCTGCCCCTCGAAAGGGGCAGTCCTTTCCACTTGGTCCCCTTTGGATCTTGACAAGAGGAGCAGTCCTTTTATTGTTAGATGTCAGAGAAAGACCTCCAGAATCTCCTGACTTTAGGGAATGGTATAGGGGAAGATGGGAAGTAAGAGCCACATATCAAACTACCCTCCACTTTATTCCCTGAGCGAGGGTTTATGAAGTATAAAGGGGTGGGAGCCCCGAGGTGAGCAGAAGGTGCTGCTTCCACTCCAGCTCTCACATTGACCAGTTTCAATTCAGCTCAATGCTCCTGCTTCTGAAGCCTGCCCAATTTCTTTTTTCTTGGCCTCTGTTTTTGTTTTTGTTTCTTTTTTCTTTCTTTCTTTTGTCTCTTGTTTTTGTAGAAGATTCAGAAAAGAATCTTTCTTATGGCTCCCTCTGTTGGGATTGGAATTGGAAGAGAACTTAATTTTTTGTATTTAAAATGCAGTATCATGCCTAAGCATTTCTCCTGTATAGGACTGCCTTGCTAGTGTGCCCTCTTGCTGTGTCTTACTTCATAAGGAGTTGTATCTTCCCACCTCCATTTCAATACTGGTTGTTAGGACCTAAGCAGAAGAGCAGTAAAGGCTGATTGACACACAGGGGGATGGAGTTGGTCCTTACCCGTTCTCTAACCCTTGCTGTGCATGTATCGGTCCTTATCCCAGAAGGTACTATTTAGACTGTGTAGACTGATGTAGATTGCATACTGTAGAGGATTAAGGAAACCATAGAGATTGGGCCTTGGAACTATTACTGCCTTCTCTTAGAGTTGTCCTGATCAGGCTTGGGGCCTAGTTACAGATTAGTCTTAAAGAGTCACAGTAACTTTAAAAAAAATCAAACCTTGCAAAAGCTAAAATAATTTGGAGATATCTTTGCCCTTGACTTGTAGATATCTAAGAGGATGAAGAAAGGAGAGTCTAAGTGAGACTCTGGCCTACTTCCTAACAATGTCTTGGAAGTGGGATGATAGTAAAGGAGAAAGGCCACGGTCCAATCCCTCTACCTTCAGATAGGGAACTCAAATCCTGAAATTACTATTTTCTTTCTGGCCTTTTCTCCTGGTTAGAGGAGGAAGTGGGAAGTAGTTTTGAGTAATACTTGGTTCATATTACTCTCTTTTTTTGTTTTTGTTTTTGTTTTTTTGTTTGTTTCTGGCCCCTCTACCAATAGGGCAATAGCCCCCTACCCTGGATGGGTATAAGGTGGGCTTGGTCCAACAGGTGCCCAGAGGGTACAGACTCCTTTCTGGGGAGAGAATGCTCCCTACCATATAGTTGACAGTGGTTAGGAACTCTCCCTTTCCCTACCTATCTTCCTTTTAACAACAGAATTCCTGTTTTTCCCTTCTTGATTAAGTGTATTGATCACCCTGCAATCCTATTATGTATCTGAGTGTGTGTGTGTGTGTATGTATGTGTTATGGGGGAAGGGGGGGTTCTTTAAAATTTCTGTGGTTTGTGGCTTTTTCTTCCATACATTAGTTCCCACCATCGCATGCCCAGGGACCACTGCCTGGCATTATCGCATGCTGGGATCATCGGGGGAGGGTAGTGAAGCTCACCACTGTCCTTTGTTTTGGAGATTCTTATTTTTGCATAAGTAGTACATCCTATGCAGATAGCTGACTAACTGTATTCCCCTTTCCCCTATGGCTGCTGATGTAAATAAACTGCATCTCCCCATTGGTAAACAGTAATAAACAAAATT + IKFJKDJIHC:IIKAGKHKI:KIEEJAEJJEEKHHIJD?JJJDG?IGFHHAGIJIK8KKICJGAJIGDI8FKKGHCJKHIFHI>IGIJJFCC@HDHGECJI8GGGDHCAFIJKKKFGJEK:J=BJHJGKJF9IDJJIH@JJIJJGIEJGGFFIHJHJKGD<47IHKHHJIJFJHKJHKHKAKJKJ;I:IIHDKH@IGG>IJ??EJHHFG5I:CIJ?KHHKEJJ?GJJJKFFJBKHKI=JCJJCFKDIJH?<FI>GAHDKKKJJEKJIEKKFJCIEKHIFIKDGIEIK?IJIAI?KD9JJI>JKIKCKJGKKHI@KICCJHCHIKIHJ=HKKKGKKGKKHGKKJBAHFJHIJJKJHJKJBKKH+KE?JCFKD@JJAIIK>JJJHHKKAFFAGKCHJHJDHJEKJDIFKKJKCJIKDCHHIIKHBDAKI;IIK@KKGK=KGI5JKJKKIDKJKBKHFEC1IKJIF8JKKKJCKKH7JJKJJJDKHHEJIIJKKIJKIJKDJBIHIJKJAKDKKEBHHK4KIKEICKJGJIJJIKHK+JHEFGGGKCKK,KJGFFIIIKFGHKGKFJJJIKEB'DGCCGIKKFHF6?IGJCI@KDKIJCJHJJJIFKKIJHKJHHGJIHHJIKJKKIDJEKIKKJIKKKGKJHJHKJKJKJ@KJ@KKIDIJJJIKK=KKHKIKKKJKKFDJFHFK?FKKJHH@HHIGJ8GJEK7JHHKKIIKJGDJKIIAH?IGAGKKIFKDIJCHBJ>KKDKHJHGFJJHK@KKGKAJHIGKJGI0JFIJJGK/HGJC>GJJ@J>IGFDHKJFCHIIKJAK>JKK?GJKJHKGKJIJIKJKKFGK;KKJAIJ@HFIJICJI3GH1HJJKJIJFJ2II5A@JGC4JIHICFDKIIJEK?JKIJGFGIJGB;HKIGKJHKJCJIKIKJJJGHJJIKHKJKKJJKGKKCJJHIHKJIBHD4IGIKKIGKIHH;KHKKGJDJCHJDKJEJGIFIAGEKCFIF+HEBIC?HKJG;HKJKFJCKKCK2JHJ?EACIJKF?HIJKAEEKJKKKKKJKIKHCJJJJ9KKEAKGIGJEGK?GFF+HIGI=IJJC:HJK:JHHJECFAGKJKFGIIKAGJAJDD@CHGJJI@H4JIJIDGHHIHJIJKJKKKKKFIHFKIJKJI=FJ@@B3IGK?IJKK-FDICJKGIJJHKJK'GHIJHH.FFDGIIEKKDKJ0KKJ=JJJJKGDH7IHE=KKKKKKKKKCKKKAHKKBK @rCer/1758/25_2241_CCS ATGGGGGGAGGCGGCCGCGGAGGAGGAAGAAGGGGAGGAGGGCGAGGCGGGAGGCGCAGGAGGGACCCTCGCCATGGGTCCACGGGCCTAGAGTGGCGGAAGATACCAGCCTGGTGCCAAACTGGCTACTGCTGCTTTCTGTGGCCTCCATGGCTGAGGACTGGCTGGACTGCCCGGCCCTGGGCCCTGGCTGGAAGCGCCGTGAAGTCTTTCGCAAGTCAGGGGCCACCTGTGGACGCTCAGACACCTATTACCAGAGCCCCACAGGAGACAGGATCCGAAGCAAAGTTGAGCTGACTCGATACCTGGGCCCTGTGTGTGATCTCACCCTCTTCGACTTCAAACAAGGCATCTTGTGCTATCCAGCCCCCAAGGCCCATCCTGTGGCTGTTGCCAGCAAGAAGCGAAAGAAGCCTTCAAAGCCAGCCAAGACTCGGAAACGTCAGGTTGGACCCCAGAGTGGTGAGGTCAGGAAGGAGGCCCCAAGGGACGAGACCAAGGCTGACACTGACACAGCCCCAGCTTCATTCCCTGCTCCTGGATGCTGTGAGAACTGTGGAATCAGCTTCTCAGGGGATGGCACCCAAAGGCAGCGGCTCAAAACATTGTGCAAAGACTGTCGAGCACAGAGAATTGCCTTCAACCGAGAACAGAGAATGTTTAAGCGTGTGGGCTGTGGGGAGTGTGCAGCCTGCCAGGTAACAGAAGACTGTGGGGCCTGCTCCACGTGCCTCCTGCAGCTGCCCCATGATGTGGCATCGGGGCTGTTCTGCAAGTGTGAACGGAGACGCTGCCTCCGGATTGTGGAAAGGAGCCGAGGGTGTGGAGTATGCCGGGGCTGTCAGACCCAAGAGGACTGTGGCCGTTGTCCCATCTGCCTTCGCCCTCCCCGCCCTGGTCTCAGGCGCCAGTGGAAATGTGTCCAGCGACGTTGCCTACGGGGTAAAACATGCCCGCCGCAAGGGAGGCTGTGACTCCAAGATGGCTGCCAGGAGGCGCCCCGGAGCCCAGCCACTGCCTCCACCTTCCCCATCACAGTCCCCAGAGCCCACAGAGCCGCAGCCCTACACGAACCGCCGGCAGAACCGCAAGTGCGGGGCCTGTGCAGCCTGCCTACGGCGGATGGACTGTGGCCGCTGCGACTTCTGCTGCGACAAGCCCAAATTCGGGGGCAGCAACCAGAAGCGCCAGAAGTGTCGTTGGCGCCAATGCCTGCAGTTTGCCATGAAGCGGCTGCTGCCCAGTGTCTGGTCAGAGTCTGAGGATGGGGCAGGATCGCCCCCACCTTACCATCGTCGAAAGAGGCCCAGCTCTGCCCGACGTCACCATCTTGGGCCTACCTTGAAGCCCACCTTGGCTACACGCACAGCCCAACCAGACCATACCCAGGCTCCAACGAAGCAGGAAGCAGGTGGTGGCTTTGTGCTGCCTCCGCCTGGCACTGACCTTGTGTTTTTACGGGAGGGCGCAAGCAGTCCTGTGCAGGTGCCAGGCCCTGTTGCAGCTTCCACAGAAGCCCTGTTGCAGGCAGTAGACCCAGGCCTGCCATCTGTGAAGCAAGAGCCACCTGACCCTGAGGAGGACAAGGAGGAGAACAAGGATGACTCTGCCTCCAAATTGGCCCCAGAAGAAGAGGCAGGAGGGGCTGGCACACCCGTGATCACGGAGATTTTCAGCCTGGGTGGAACCCGCTTCCGAGATACAGCGGTCTGGTTGCCAAGGTCCAAAGACCTTAAAAAACCTGGAGCTAGAAAGCAGTAGACTGGAGGCTTCTACAGACTGTAGGATTCAAGGTGATATTTGCAGACTGGCTTTATGAGAGACAACACTGATCTACTAGGGGCTGGACCCTAGATTGGTTGCCAGGGCTTGTGTGTGAATCAACCCTAGGAGGAAAAACCTACCACGAAACCAGAGGAGCAGGCCTAACAGTACTTTGAGCTTCTAGAAGAAGTAAGCGGGAAAGGAAGAGAAAGAGTAGAAAGTTGGTGCATCTTCTCCTCCCCAAGAGCCTGAGTATAAGAAGTTGGATTTTAAGGGTGGGGGAGCTGGGATGGGGAAAGGTAATATAATTAAAACCACCACAAAACAACCTAAACAAGCCATGTTCATGAATAATTGTAAGTGGCTTCTGGATGAGACCTGGCAGTGTCTCTACATACTTCCTCAGGGAGACAGCAATTGAAAATGTAATTGAATAAATAAGGAAAGGAACT + GG>IIIKKIEKACKHKJKKKIDJCHBDIGCJ0IJHEGJHEJKKHHHKH>JJGBGGJG:CC@B@J=8FGIIJJKJJJKGIBG8HHJKCJEDFHBHGKIFHIK;HGFIKFCGJ,>EIJH;KJHJK2JJEGC.ECKCKJFKCEKHKIIJFEBJ?EIJGKFIIKGHJAFGI2JGEIHGGIC8HKJHKJGKKJJKKBEKJKGKKIJJJJ=KEJHCIIJKDEFK;JJ?HIEIBFJIJHG9H@CF@C.BBDHF?HG8KHB?IFKK@>GCHIDGHEGBDKJJ(KKKJDJ;KDGGHIK6GIKHKJJKAGKCJKGKDKKIKCJHKIKFCJJBBGKGKKKHGJCJJK8IGIKEIHJIIGIKEIKKIKDDJI%GFGHIHK@JIJJJIIGKC@?IICID5IDJH=J>GIHIE:KKJBHJIHGHJJKIHEJKH?JJHGEBKJK7KIFA>IIDJGFKEHFG>GKKGJHJJJEIEJKF75GKJIIKKJJFKIIJJJKKHHKDG@=K;IKKIEJJJKJJHKHFHAKHCIIJJFJKKJ)KIGFJIJ9KKHEKKJ8JHKKJEKIJIH?JKJJKFKJJJEKKKKHKKJKGBKAJ+JKJEHEJ>KKEIBIHIJIHKJEKGJK5H7KKKKDG@KIIJFEKIJFKKKJJKJKHK=KKJKJJHDK?KFKKJIIJHIJK5HF8<8DDKBKK;KJ.KJ=IF8KJHJIKJFDKJJGJIKKKJJKJJGKJKJDJH8KIKIJJK9@KJ;KIKHJKDKKJJKDJJKH=JIKKJEJKFJFCKKKKKJIJK.KJK=KJFKKKFKKKHKKKKKJKKJ0KKGKJKKIEKIJKKIKKKKKJKKGJKK2JJJ>)KKKK8K6KKJGKDKIKGKJKGIKJKJKKIKDIKJJAKJ?KIKKK@GKKIGKKIKJKHKJJJKIFKKKJKKKKK0KJJKJJIKKKKJICJKKKKJKKIKKKKKK>KKICKKKKFKKHK=K?CIKKKKJKIKG@KI>JK?K7KKKKAGIKKCKKKKK@KEIJKJKIKKJKKIKFJHGK4JKJJKKIHGKKKBKHIIJKJJKFKKJKKKEKKK2KEKHHKJKBHIKEKKKBJIIKKKJFKKKJK;KKJ/IKKJJJKJHKKJKHKKK0KKKKK:KHDIKKIK:KKKGKKGIEI8JKKKIKJKKEKKKIKKIKGJKJKKKDI:KEKKKKKKIKKKKKKAKJKKKKKKIJJJKKKKKJKKJIKGJKIKGKKKCKKKJIJ;IKKKIAJIKKKJKH=KKKKKJJKKKKKKKIKKGKKIK,KKFKIKKK @rCer/1759/1273_59_CCS CTACAGCCAAGAAGAGATACGAGGAAATTGTTCAAGGAAGTCAGCACTTACATTAAGAAAAATTGGCTACAACCCGGACACAAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGATGAGAAGTTCACCCGTAAGGCATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGGTACTGTTTCCTGTTGGCCGAGTGGAGACTGGTGTTTCTCAAACCCGGTATGGTGGTCACCTTTTGCTCCAGTCAACGTTACAACTGAAGTAAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATTCCTGAACCATCCAGGCCAAATAAGTGCTGGCTATGCCCCTGTGTTGTGGATTGCCACACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAACGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTTATCCACCTTTGGGTCGCTTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAAGTTT + #"$%%(%(%$%)$&,++(+,(,.*)($-(-,&$.+0..,++,%,11//1.11+.0(+,+*.$1,.*'..(,,+**,%-/,+$"*/..*+-&)0++&.0')%'0/,+.'*)%)$%)----(*('(*(),+(),',,(,,+,,())(&(*,(-+-,-+*,'(%&%(+)$$&0++**(*+//($&)*)..*004..111-,&3/-2221-.3.+,1)315630212+.-43-)*.+14//''&(,*,),,-+1.12,.-'$1,/-,,'1)/,+&++*.1'0,,-&,-+,//$.-2110))&('$'$(+.,&&)%(',&/,/$0+++',*',,111,0.&*)%,*,,,'/0),+/(/2+-0-%&,-'&)+%000,'.,+,-*0+*+-1-0/,,,$(+,/,+%+'*(++-/,&-/,.1*/1-1-.-)((--1&))((*10,.++'-,)&,*-+,0,).(***,)%.+%,.,/-(++**0((*).,/0).)*.*...1,)1++/,*.2-/.&,).*)+-+/-1..-,,&-,//.+.0//,-)()+(),/*,.,0*-1*/,0+,+10./-,+'+*+/2.0,/&0,.+.211(&--).,/1.0'%%*-,-.0&,('(,)&)'%-0&02/,$%%&+)+),*&/,))&(*+..-'+,-&(,*0/$&)0--2/+-.*'&&%,11,12*$**.'0)0.22.-*''+(0)$*),,--/*.11*1--1,1,'/+**+&-1.***./.**)))('**+,&-,-*.,)1-.-,*++**&('/1,-'-.+-./1(-+100+.'$)&.,++-/-(,&*.+&(&,*$0-,'.)+*$)2.*250/-,2**.-31-222+,-0*/0/0.0/44'20+/-/)110+23-).+-402*/414.,++4.0/$/,0%/-/5.032133/0+-.+4/*,1*-#(,633.$1,,.-+'*)'%%,)0.4+41/.+'&(%/.4..,.0/3420411..$0/1-56.'-*+40-*-0-,0&202104.6504-/021(1+...%12.),,3/+')/)220,-#10/0232..///-('(165.))&1,2++*-241.63+0)+)4+.*443+1/0)5201323'5030-*0+34,.1(1(%-00./4,+++*'-&*.-(1.0../0/&0/0)4-50.1415-3/6/521'&(+.+,2053.--*01&(-%/),0/.411453)-)31.2)2)-+-)-(%&,)-+ @rCer/1760/551_63_CCS CCCATAGGCTACAGAAAAAGGTCATAAGCGCATGGTTTGCAACCGTATGTGTTTTGTGCAGTTACTTCTCTTGTTCTTGGCCAAACTACCCTAAAATCCTTACCATTCCACAAAGTTGGGCCATCACTTGTGCTCCCAGTTTGAGTACACCACCACATTGCATTTCTGTTTCTATCATGTCTTCCAGGAAACTAGACTGTATTCCCAGGGTGGATTTGAGTATAAAGAAAAAGGTAGACAAGGAATTGCCCAATTCTAAAATTCTGACTTTTACTGACTTAAATCTAAATGCTTCGTTTCTCTGAACCAATTTTCTCTGATCTTCTCTAGGGGTTTCAAAAGGCTCAGTTAATTGAATTCCAGGAAGTACTCAGCAAGTTCATAGAACTTCTTGAGACCTAAATTTCTTCACACACACAAAAAAAGATCTTAAGTCATACATTTTTAATTGTGTAGAAGTTGTTCAACTAAAGGAATAAATGTCTATT + ('$&'%'$%('))'('&&$,+'*&+,)+)+(,-.)-,('+)))#'$'&)&)&&&#'&..-+%"-./+0/,.-01,/1+,&0+-/).)/2-.,///$/20/+-0/0,.+(*,--).*)00.0-.-111+---//,22,'020'10+-0+(+(*,+(+,,'()--))++(**#),-'--/.*-.+*)),//,(,&),-/-,/#/*,1(00',,,'.-&,,./+'$-1,0.*')$(&0(-.02-)&,'*-0/*&/&/*,*%),#+,-011.)()#.-11../.0+/00(.+,1/..%.122-,.0000).(-,-,1*1,/./&*,)-./1111%,0.1+%//0%*,.++).0')(2-110..2-0-'.-.,1//11-/-(,.&,*()*2)+.'$$&)--*1)+'*%11(1..**.+.-,.'*-/.*($.-*.-*,)/0,-*)-0,*-'%'$1-/1/),//-++,0200/).01.*/11+1--0./*-+0-) @rCer/1761/1558_62_CCS ATGGGGCGAGGTGTTCTCTGCCTGTGCAGCAGCCCCTCCGCGTTCTGCAATCATGGCTGTGCTGGCGGCACTTCTGCGCGGCGGCGCCGGCAGCCGCAGCCCCCTGCTCCGGAGGCTGGTGCAGGAAATAAGATATGTGGAACGGAGTTATGTCTCAAAACCCACTTTGAAGGAAGTGGTCATAGTAAGTGCTACAAGAACACCCATTGGATCTTTTTTAGGCAGCCTTTCCTTGCTGCCAGCCACTAAGCTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAGGGATTCCAAAAGAAGAAGTGAAAGAAGCATACATGGGTAATGTTCTACAAGGAGGTGAAGGACAAGCTCCTGCAAGGCAGGCAGTATTGGGTGCAGGCTTACCTATTTCTACTCCATGTACCACCATAAACAAAGTTTGTGCTTCAGGAATGAAAGCCATCATGATGGCCTCTCAAAGTCTTATGTGTGGACATCAGGATGTGATGGTGGCAGGTGGGATGGAGAGCATGTCCAATGTTCCATATGTAATGAACAGAGGATCAACACCATACGGCGGGGTAAAGCTTGAAGATTTGATCGTTAAAGACGGGCTAACTGATGTCTACAATAAAATTCATATGGGCAGCTGTGCTGAGAATACAGCAAAGAAGCTGAATATTGCACGAGATGAACAGGACGCTTATGCTATTAATTCTTATACCAGAAGTAAAGCAGCATGGGAAGCTGGGAAATTGGAAATGAAGTTATTCCTGTCACAGTTACAGTAAAAGGTCAACCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGATTTTAGCAAAGTTCCAAAGCTGAAGACAGTTTTCCAGAAAGAAAATGGTACAATAACAGCTGCCAATGCCAGTACACTGAATGATGGAGCAGCTGCTCTGGTTCTGATGACGGCAGGTGCAGCCAAGAGGCTCAATGTTACACCACTGGCAAGAATAGTAGCATTTGCTGACGCTGCTGTAGAACCTATTGATTTTCCAATTGCTCCTGTACATGCTGTATCTATGGTTCTTAAAGATGTGGGATTAAAAAAAGAAGATATTGCAATGTGGGAAGTAAATGAAGCCTTTAGTCTGGTTTGTACTAGCAAACATTAAAATGTTGGAGATTGATCCCCAAAAAGTGAATATCAATGGAGGAGCTGTTTCTCTGGGGCATCCAATTGGAATGTCTGGAGCCAGGATTGTTGGTCATTTGACTCATGCCTTGAAGCAAGGAGAATACGGTCTTGCCAGTATTTGCAATGGAGGAGGAGGTGCTTCTGCCATGCTAATTCAGAAGCTGTAGACAACCTGCTATTTAAGGAGACAACCCTATGTGACCAGAAGGCCTGCTGTAATCAGTGTGACTACTGTGGGTTAGCTTATATTCAGATAAGCTGTTTCATTTATATTATTTTCTATGTTAACTTTTAAAAATCAAAATAAAATCCCAAACCTTTTGAAAT + 467;<(>90584392;598B?3?=1?C?.6:<9AECC:CFE=CAB=AC8=;=AEBAECFDD5@A8EAD>CEBBDBBA&B>FEAD>A@9;?D?:>?A>?8GG@DD8?:4CGBDE>B1@C@AFE?BEBB=?C@ED.>C69CGDEB@8>;8>7:B5EB=;=FD;AA>@E<>?>7D:9B=@;?=AA8?B4DE?DCGAB?@<,FEEC:DDF@DB:B<:D7ECBACCABB4<2BGB3DB>FDFEGEE@BF>78=988,9B8@1AD;9??+C:;EEB?B?=/A=B4D:5BDAECADEB>@B8C?E????@?7;<9EA=<;=?D4=A36>A<;26;'B@D=:C=5CADF92=?B8@BBDA9:9E<;>@5FB>EC@B@?96?984>;B=@C=ECD5@6;A=;7A9F@D3:1@8BCBA;FDG@>B;FDF<=?>-3@E085;9=B=>45D/A9@@AA9?B6?C?=:4@AA6>.>B;B<<8@FC:99:AA?<>?;9B@<3@<@DA308)9@?>8??@-@@==@>6;=<78>DA/DF?B??5:?=B>@E9@3<<9<:;?=ADD?>9B@=D@?BDE?DA.EA?<@BB6>?3;$88EGAD<<9?:18<8A:B?3CDED=BD?/AC3=7CA>7?D9;:.=<@DE8BA?BC5ED?A@>><@EB>B9B@8?>ADD4??8BC>@?=3:>CGF@B7C?><:5C@@AA=CEAC8DGC@979636:>:B?->4EA5C;=:@8;>?BCDA?>=<@8;=A;9>>C3:B:A@C>?E?>G??8379BB@:7=;A8B>59?=@=EFB667AA74<83>A;9>@DEBGCA:GAB9<=:ABDC6==;>>?A:?@?A7A7A4BC69@5A9;@BAD5<=.BEB3@BBE>@7;@8<:==FCB>8>AAD>=B7==,47>>9<E@D7ABB19@>9A;>5AE?=B=@>=&GGD>1284<0/A?DDCEE=>@2<=<@C??2C@@A@EEDCGFF;AE9@?1B><72=9??=6:=A@?B:??1F2AA*E3B2,'6:>6:@<@CCBD9AA>3A2AA<(3=@4:==;@;9C@6=0B??=@DFBAC>7DDECEAEEEAC>>=68=34?A4EDB9A;A:CE@:??93A8?:>6=7;8<2@@6506(=5<=<8==@A8=C?=;<;?<<93><:@??CA?7:@@<>?6?4736=,*58:#@A>?>6@A9@;?@3=CCA,<:=7A6?>@%@57=5--27@;9?>=A@6/?9>A3998+=<>?($@9597AC7A?;)>A2$<=>A?<>?=<==>>7397)'8.8/4>@@)<77:6-$4:;8-89<80::5;>5;;@AAA2A?<68@5-(::???%;<;875'718-;=+#*:6=6)4'%;?;@0<:>B@B2888@%=:9;1$;<*(9;B75.@5095?4:<.8.;5AA:9>=8;9;$:-;498::@/6=@>@=880:@&;45?@63;?<>;8/>B?>9=:#:'7=B<@<56788;:=-?5>=043-4<&=;==9?=?<3:<%=<4@5/79<,5;::>:@AC@:80:@;@=,@;+=)%>;<:C?97-249;79;>BA6B=76<>BA9A%>@B=<=:A=996C*A=:;0;>2:BBB?>AAB@2987=9?/)>@AA=:?B1<9>6:B;,?=B8>AAA-?<&2,98?2><<(??%;?,?-(4?56;CA886BA(<9A;?>C0@BB<=;-89=>A=B3>8:@94==:A?>9A;C:?@=?:B:C>=+:)9=C;;?<6=>?<<9A+BA+5=C=B/:>768:886=4>@>4CAA@95:/;9A:>*50@<>8;-B.>A,@6A?C<6A9A5AA:$7<:0CA6;;@??B?@7:@>:B>?A8=0)=?@BC5>/>==?6;=1>6?>=4>?<=46=@8*62?>=<>@?C>B28@;;>6;:>8@7AA>?/.(9;6:84@<@>AA43A:B<=A?<,@??-=5;=@;<@>8A;C0;1=93::7<@CA=C2884<988?;<9:CC:BB>67>813?79<99<:B;3>C5>>@8?>>CB)<9<816;9==-?B?(4?C=@74@;8@2A(<-/1+08@96>B=6,;337';8;>$9&=;4-0<;=78B:C,=;@BA;B;8/A@;7?=4A?76AA5>>8C@7<.@@A86=>6A==2A2(>?<9.A=>+85603?@>@7@.>:=B3@%79=9/8AB??7?7>>@B?:@=?6A7BA<4@?5<756A+?>:?3BAB9CC6=B=97&64>7@.994;:76;>AAA1?4B9/@/58:9=BB27B?<;9@B?A??>=(=78>09*=@?:>@0B;:>2>@6?:@;=;):?>&@@?@?8>66365)662(6<01*688>=<=4AAA>A@:$;3+8;88::%8<'@'>;@?A>8@>A5@4A;?7<*@=@=96A=6A6@AA?;808;?B?>==3?<331BB?=):2>CA@448>;<=19/616<=B;8C50A7B>=>@<;%=<=>B?<7C@B==1A99>B=B7C4=7><4?82*9>?)&0:96=7595AA;8?=?9<>>B?:73:?C=>>(8750*+268731/6==??6;BCCA<99@;2;:@3:&>;@A=;=;->*=?@3C??/?=78>CC;@>?>>4<3A?<@A==-?3A<=A@7?1,:<1<6>6>?EFCD<@>>B@4CE@BD?@@6@:6ADD>A>E;DB7?)<>3;:@>C8A7@'8=>FE?.>?2>AB?DC< @rCer/1763/0_1627_CCS GTTGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAACTTGTTTACCCCTTTCTCAACCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTATTTGCTACAAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAAGGCACACCCACACCTCTCATTCCCATGTTATAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGTCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCATCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAATCCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTTCTTCCTAACCACAGGCTTCCACGGACTCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATGCCGCCAACTACTACACCCACTTCACATCGAACCACCACTTCGGCTTCGGAGTGCTGCCGCTGATATTGACATCTTCGTAGATGTTATCTGACTACTCCTCTAATATTTCTGTCTATTGATGAGGATCCT + S&'&)111),0--,*//2*/01--*-2456254665134622+5325.522/3/*+,.-1//4,140.+4/43.////6403-*&.25)155.402-31+/3,(,*-%03420.4033$'&+,041..0***40210.14/0)+/5//*260(0*-,/%2,)25.-164.-*5111+,)''(0+)4,-)%++-,4530//(240565503,(./0-)(.*+61.'-#)(,1/632,)/--)043.22650121511.,154-4-34012*4/+(--/((-01,22164&2..((.45464.')-)-024.%1-%*(000*+--5+-./300*.44640225254,(63/15/5/.626),.+/*..2/2+56156*13.*-/)%(%+)&(+$%-&,00*,))10**.1,*-/'0,11--+-1.*&,-.++1,1(,.-0-/,..-2)0-/./1'-.1,%%'%),+-.+('+,+*&/----/1)*-0+*0+2+-01+%()').-,.,,+$'++++*--,1/,.20*$(*.0,)--.2.0*((+*-.+-*-0),/0/+,46231)3-0.4550146*'(2**1,+('(),.*.+*1-1',0-/---3*.-2./,).(404*/4,1/+,./'/50,$),2'35215)*3/2-504)050*332111/()&.41*0'*$'('-020,.204*256635/0446,253325.62216622/51+35515526624*51+./6651155&*)405-634+.3-12..30)4000636/0530/4%.(1/(00*./.0)2303&411.0/3514/-/'0.+.12-0.)#&&&*//2**/*010...)3,0-1(-2,10,015-/(,+))-13.''#"(3#+,-)1/.44$/,)*/21*/402,2*-..,-)1-(-&&&0444620+13&+0-10,'-*)//2/040./1+300'0,($).1/%+&.0.0).--++*,.#$,+0,145,4%31100010621-*//(+10304.1.&(231425152/041*/%/02/113/*+/&,,112001*45.+,,2-+.//.2,3112311-45646.1)))+*34/+5/-,3,33-/0/'%&),345165-*)/342--3.)/2.55+0515.1.0.-+(+444.3)$--./+0)3.$(%%*1(1'+$&//%,*#+**%'1)0/0+-.--))/24*'120,1-($*-,)&0-#'.51+2.+%(,/)&+$+310,,4+-1/04655%$%/+.+2105011060*./42&1/24*45010$+.*.250055,423$.*014462/3645)2544-1103/*/042&$(,,/-&+-*/0.--*-).*.54(,-5+*'++)1+,'+0451*+/'0**,**(((,,,/(0.*(,,..&/)'/11020)-)+)1+-*,')()0)+--)2*%+(+%//0)/%../2**+0).11).,.10+,-('#%/112.,1*).$#(%,)---')*+*+))(*.0,,.*.1//$-.+),,,,+,'+*-+#%"%'%+-$&,1/(&**./,/+.$/),++-,($($'$$%&*',+/%+-.0+-,*+'"%%&)(('*)-,(.-/(++-),)+&&(+-(#&++$//.,1,1)11/1+&),**1.),( @rCer/1764/1728_58_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + KKKK5KKKKKKJKKKKJKKGKKKKFIJDEKAIKKGKKKKKKJKKKHKJKKDKGKKKKKKKC=JKJAKBG>KHKKKKKKJKKKKKKKKKJKKKKJKKEKJGKKFCKKKKJIKKJAGKKIAKHKKJKKCIKKKKJDIKHKKKHJKHKDKKHKKKK6KIJKHGKKJKKK-KKH@KK6KKKEDBKKK>K?JJ;HKAKKKJKKKKKFFKFKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKJKJKKKKKKKKKKKKKJKKJJ=KKKJKKKJKKEKKKKKJKKKIKKKKKKKKKKKKJKKKKKKKKKKK:JKFKKKKAKK;KKKJKKKIKKKKKHKKGKKKKKKKKKH@EKK3KKKKKKKKGKEKEKKJKKKKKKJJKKKKKKBKKKKKKKKKKKKKKKKKK@IKHKKIHKKKK.KKKHKKGKKKKKKKKKKKK=KKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKK4KKKKKKJKKKKKKKKKKKKKKHKGKKJKKKKKKKHKKKIKKKKKKKHKKKKGKKKKKKKKJKKKKKKKKKHKKJIKJKKKKKKJGKKKKKKKKKKKKJKHJGGIKJKKKKIKEKIJKKKKKJKKHKKKKKKKCKKK5KEKKKKKKKKKKKKKKKKKKKKJKKKJKJKGKKKIJKKKKJKIKKK6IKKKKKKKJK9KKJIKKJKKKKKKKIKKKKKJKK=KKKJKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKJFKKKKKKKKKJKAJDKKKKKJGKKJHFKFKK=@ICJK;KKKIE7KKKKKKKK3KKKDKFKKHKKB=KKKJJJKKKHJKBGKKKKJDJKJKJKKKKKAFGCJKJKHKJKK:IKKKJKKKKKKK9KGKJKK5KKHJKKKEHF-H>JHK?BKJKKKJKKKKIIKKKJKKKKIJK=JHJJ@IIAIIKKJKKKJKKKKKKKJKAKK=JKK.JIJJ>KKKKFFBECKIKIKDKFKJKKK:KDEKJKKBKKKKGJEKKJ?KKIKKKJKJ7>KKKK.KJKKKKKIKKKKKGKKKKKKKFJKKJKKKKKKKHJKKKKKFKFKKJFKKKFKKKKKJKKKK5IKJEKJJGIKFKKJIKIGJJH?IKKCK @rCer/1765/1226_57_CCS TTGTCCCTCCCGTCATCCATTCCTGAGAGGGTCTCAAACCAAAGTTAACAGGGAGAGGATGGGGAGGGAAAAATTAGAATAAGATAGCATCTGATGCCTGAGAACCTCTCCTAGCACTGTCAAATGCTGGTATTGAATGGGACTGAGGATGGGTCTCAGAGAGCAACCTCCTCGTAGAGAATATCCCAACTCCAGGGACCTCTTTATCTCAATCTATTTATTTGCATCCGGAAGGATTCCAATAGTAATTTATGTGACCTGGGGCAGGATACTGTCAGTGAGGTGCCCAGAGCTGCATCCTTTTCTCCATTCCTCCCCATCTCCTCACCCACCAGGTCTGAATTCTAGCAGGCCTGGGGTATCCCACTGCTACACTGTTCTGTTGCTTCCTCAGTATCTGAATGTCTCAATTAAAACTTGAAGCTCTTTAGACCAACAGACTGGTGAGAGAGAAAGGAGCTTATCCCCAGCCCTGCTTTATACCATTCACATCCAGGGCTGTGTCCAGACAGCACAAAAGGGCAAGGAGAGCCCAAGCCCCAATGCCAGAATTCTTTCAAACTCCCTGACTCTTTGAAGTTTTTACTCACCCGTTTCAATTATCCTGATCCTTCTCATCCCTGCTTGGCTTCTGTGCATGTGGTCATCTGCTGTGGCCTGGTGTGTAATGGGTTAAAATAAGCCACTGCCTGACATCCAACATTTGACACCCAGCAATGTGTGACTCCCCAACATTCACTATGCATCCTGCAGCTGAAATGGGAACACTGGCTGCCTCTCCAAACCTGCTCTTGACAGAGATCTGGAGTGGAGCCAGGCCAGAGGACTTAGGGAAAATGAGAGGGAGGAAGGAAAAAGGGAGAAGAAGCTGAGCCATAGCTTAACTCCTACAGAGTGAAATGAAAACGGCTGAAATACCACCCAGGAGAGGACCTCACCCCAAGCAAGCCAGTGAGCAGTCCTGCCAGACTACTGCAGACTGAGAACCCAGAAGCTGGTAGTCATGTGGGCTTACCTTCTCTGCCAAGCGACTGGAAACCAAAATGAGTCACCTGTGTTCTTAACTCACCCTCCCGCGCTGCTGTGCTCTGCCCTCCCACACTTCCCTGCTATAGTTCCAGCTGCTGTAACGGAGCCACTCCAACTCTAACAATAAACCCAGTTCATTG + M243BJ97A'0>HJ4DGF5J=C$A@DH@C65C?GAC,>AH?D:>1E9>>E@G@<@E?1=9>E(A=DB976=9ID?/!).!#9/:'+"$!!),+25B&0-6>:'))&=?FB(@>4=+>@?;;8;=BGE86C?:0;<1ACIAF>?CEHB5?A?<&7>;@;?>::":1?:E6@EC7==%8!":=@)::/2>,>=<33$<:62@2:<1<8;9$%&?9:AE:.2=@833/!-8AH1=7@8;C;ABFED,52/@$98=A>-5=9<(4GA:D0GCC':BA*=B8564;769>?3:>=?@'=F:G;C-AIFHBD<1GGD;<(D0/?HF1CACD@CFF&;F1CGDEC&CAH;DE,8:B9JI(85>D+G3EH2C3C;CEI=FII<8;HHJ;GH?GCA5I.FI.963+6JEDIB/D?CH;&7?46F3AKHII1;DFHF?F1=698DE'D?9@FG'CIEJ/2>:=&GIGF06'E>I1H8CIHHIHKAEFEF(KCJIDFK5HCFK0ACDJ5JK>H+:EB<>F<-<8F=='=5<;H&@(AD;@&93CG2J.?>EI/GGG6FCE)FGD+6KF:=DG7>J7KFD)IIKJ'EI+G:K?GKA2/HJD9J9JHFGFK@G65FKCCJJFJEI@EJ<85>;BC/HI*FCG=?#@AA25FG/7I/?5EFD;H//,7;CE&K8<;I6HEDH+;G86@8D=FEH78I2J@AFHC8?@+2K.K8KKK/AD;9C+9>9(DAGD8?H)>)=A+EHG0=JJ%&5DI@IE79EDJBB@6#2+3:A*46:@I1BG)F>=4GKG9JKAD6?GI@EA-FKJ?AIB @rCer/1766/25_2192_CCS ATGGAGGTGCCAAATATGGCGTGGCTTCTGGAAGCCTGGATCTGGAATCATTCACCAGATTATTCTGGAAAACTATGCATACCCTGGGGTTCTTCTGATTGGCACTGACTCCACACCCCAATGGTGGCGGCTGGGGGCATCTGCATTGGAGTTGGGGTGCCGATGCTGTGGATGTCATGGCTGGATCCCCTGGAGCTGAAGTGTCCCAAGGTGATTGGCGTGAAGCTGACAGGCTCCTCTCTGGTTGGACCTCACCCAAGATGTGATCCTGAAGGTGGCAGCATCCTCACGGTGAAAGGTGGCACAGGTGCAATCGTGAATACACGGCTGGTGTAGACTCCATCTCCTGCACTGGCATGGCGACAATCTGCAACATGGGCGCAGAAATTGGGCCACCACTTCGTGTTCCTTACAACCACCGGATGAAGAAGTACCTGAGCAAGACTGGCCGGCAGACATTGCCATCTAGCTGATGAATTCAAGGATCACCTGGTGCCTGACCTGGCTGCCATTATGACCAACTAATTGAAGTTAACCTCAGTGAGCTGAAGCACACATCAATGGCCTTCACCCTGACCTGGCTCACCCTGTGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCAGTTCACCATCACTCCAGGCTCCGAGCAGATCCGCGCCACATTGACGGGACGGCTATGCACAGATCTTGAGGGATCTGGGCGGCATTGTCCTGGCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGATAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGTCGCAATGACGCAAACCCGAGACCCATGCCTTCGTCACATCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCTCAAGTTCAACCCGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAAGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCCCAAGGACAGCAGCGGGCAGCACGTGGACGTGAGCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGACCTGCAGATCCTCATCAAGGTCAAAGGAAGTGTACCACTGACCACATCTCGGCTGCTGGCCCTGGCTCAAGTTCCGTGGGCACTTGGACAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAATGGCAAGGCCAACTCCGTGCGCAATGCGTCACTCAGGAGTTTGGCCCGTCCCTGACACTGCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGACCGGGAGCATGCAGCTCTGGAGCTCGCACCTTGGGGCCCGGCCATCATCACCAAGAGCTTTGCCAGGATCACGAGACCAACCTGAAGAAACAGGGCTGCTGCCCTGACCTTCGCGGACCCAGCCGACTACAACAAGATTCACCCTGTGGACAAGCTGACATTCAAGGCTAAAGGACTTCACCCTGGCAAGCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACATCCTCCTGAACCACACTTCAACGAGACGCAGATCGAGTGGTTCCGCGCCGGCAGTGCCCTCAACAGAATGAAGGAGCTGCAGCAGTGAGGCAATGCCGCCCTGCCCCATCGCTGGCGTCAAGTTCAGCCCACGTGCGCCATCAGCGGATCCGATGCATCCAGTCATGGCTTCTTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCTGCTCAGCCACGGAGTGACTGTGGTTGTGGTGGGGGGGGTTCTTAAAATAACTTTTTCGCCCCTGTCTTCCTATTTTTAGTTGGTTCAGATCTTAAGCAGATCATGCAACTGTATTTATTTTTGATGACAACACTCCATCTAAAGTTTTCTCCTGCTGATCATTTCGTTGGCTGAAGATTCTAGAGAACTTTTGTTCTTGCAAGGAAAACAAGAATCCAAAACC + A?6<9/=/,*:1?><<=%8:;A(@@:?=B6?1?5.?1&9>:)7=C7C>::7337972.1);0-?A75@%999?>;AB@@7<(9;:*<>=;A>-A42>;(A9A?@BAC<-<1A6.*'6=66>13A43A?&(&3&=??;$3;9:@A=9?=>138C&;<=:65>:;-B@0@,=;<:+?*?81779;>>AA/==(;;:%A?(;<<6A@68=)>:;(<<:C>'5)796%<=78)=<=A7&/=:7%6-49*;(;4:8<;?A5.C<=5A-?589?=<.?>:>(<>./67@>>3;?3C=7?,;?47:/3.??99#=;")=8C@@==';=A9<$89C>?3@&>@&:4C@AB2A53:=<<1BB??B>1@>:<<$>)01@<91:<';C<68&07=ABA7?=7@4>4<51;/9=@:>$3:1@=9,??>:*>;2A.@>7A==?9>>?%8???@4?>;$>B=.8$+292461/1>?.+?3?=;>CC?;7$6=5<@BB-BA@8B6C:2>2;>6<-<999A7;9:8>9?/A>188:>?>2@>A7C?>A;=A<>@5@?51;62CCC>@A>B5;;77BAB;:?1=/;>6467>>>63@&>46>)B4AA?5@=:<=*><=(=5:%;345BC>A4@?;?@?;<<$<;?42:;'34>44&&/4297?>8;?@6:>=8<9:7CA<%=74:+<-B?;$>@59B@@4@A6880;=B8;B<=(8,@@@<>>5(;&72B=;>&;<===8C;A7>=?1>:0?03='>@>=7:2A8092<84;::8?.*%24.=4?A(9=219AB:B/?>>BB>8???@B>6+<94>>8<;9';>@;&('9<<>?=AAB68==>@9??A3A4(>=;A::A=;?=>:8?;+@7=:A0=7A==;>8@:?:;4B7@?+A3$:8-+)?@@B=CC:&;;>B<=61A,:<8-@=??<&;:44/>*;919;<<5=&<=3=?8@??<7C?8;@?6(*B@;9B;7/A7>7<1?@CB8@B@(=>$>4%$5&:;58=>+67=.BA<;':;,9,?3)A@9B6&5=CB>;?7=9&<3==:47B-??@2B5'@9?>:<8>0==2=:57>:><>=BA0?>8A:<0.&=>82?>;;<>:'>4C><)>@2@:86CA/??@=)><5@*@'8*;?@5AB??;A=7AB?(7:.9;=AA=B?A6C?67,CCAB*B>4<<@9@9:'68=5>0;;=/A71>82;=;@3>?5=06:@9<2>A;7474>>?5>/68':<49;;5#=.9=28/4:.>0@2;:9.<6=)2.8/)0?8A&AA?)B*%=:A77,=?8+7>69999,-AA2+:>7C<+$4=9>:.2>6;?BB9/@42AC@>,@3,@B;:=0>@@?4.;3A5:<4<;6:?@A6AA=;992.?8*?*8;?=<2=?@@>3@=3%;645;9&<45<-=14)>5?A,@;B2?;2-<<8;C72@:8@B4=7BBAB3?A?=:>/A?B::>AB5A<&@><):;A8@?:6$488>?<>;=-@48<;0)>B?9A?<@?CB>>88ACB=9'@=?9?/:8<63@8A8;A<<&@@CBADBB>CGDB6A8DCB=9CD@EFAAB8@0>=:B?@,E24D;>E'DDF8FF;8D,@2B9'AC7/59:A>>EBCFAAA%ADF9E@CF?EEBDD@-B:@C(C8BG2/GB9G)D@E;@=*A0+,9B/A<;BE>F@C=D'??99=&D<@A0;BC$ECC3FE?C<9>/BE@BB6?2D3FDGF>FA*==?A??4@ECB/G(@7AC>C0>B9?#'9@:76E9*EFC6C/B,EFD&/EA@G5/C;FGE/? @rCer/1767/2072_57_CCS ATGGGGAAGTATCCTGTCATGACCAAGGGTTATGCAGGGTCGGGTGGTCTACCATGCAGGCCTCTTTGGACCTAGGTACTGACAAGTTTGGATTTGGCTTTGGTGGAACAGGAAAGAAATCCCATAATAAACAGTTTGATAATTATGGAGAGGAATTCACTATGCATGATACCATTGGATGTTACCTAGATATAGATAAAGGACATGTCAAGTTCTCCAAAAATGGAAAAGATCTTGGTCTGGCATTTGAAATACCACCACATATGAAAAACCAAGCCCTCTTTCCTGCCTGTGTTTTGAAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCGCAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCCGAACAAACTTTGAATAACATCAAGCAGTTTAAGAAATATATTCATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCGGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTACTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCGGAGAAGATAATGCATTTTCCTACCTGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTCGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAACCACATTAGAACTGACGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAGGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATGCAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAACCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCATGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCACGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAATGAGATGCAATTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAAAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAGGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAATTTGATGACT + AEHGE6D8?DC@JEIDDFE@IECCGIFHAI@?IHA9FHCAE<=;<8>A=BEE@BAD@CD<ACB@D9CE3AB69@A>DCD@+BGCEEE5A;DAC7EC?@DECECBD30ED9@>;)EE=EF3BDEADF;?FDCABCE1D<6FABF7?AC?BACAC=BA1@6ACCBAAI/H7ICGC<@F6?9??>;C4BDGGIII?BHFGGGD>BHGEDC?0AA7F?.C/:FICIFIHIIHEGGIIDB?>IBDA?;?C;CCC@DIBEAHEHICGHGAHHIA9E8FG>5>8GFIJ.IIEFABEG?DFEIBD=CB8E@E+;GI07?3BJ1GHFFHCHHIGEIHGF>D?GJJ7?FBEHIC?:HHHEDD>HBBH?;@:EJACD4I6GD@ECGIFIFGD7IAEIFHIDHDA?EHJBGAEDI;IFIBDC@;DDF6BBBD4BC?CBEF@7IE9FECFH9DGGCD9GBFJEHBF8GEEH@FFEAAHD,H;BIJIIIHCID=BHE87?@==:<=>F7?>DHFDGEH?HF@EBHJIAIH??HHI;HGHEAHH.CH7HB6@FIEIGH58BH@HG>GGFA:FDGEHIHBG>HB@FG@G>GEEGH9DDD/CIIGGCFDF=F;AGIJ.GHA1CGG>DBGHE:B?>GIHICHDH@7>FEEC?E@JHIGE=H?HIF?HE?F?FIHH:E<@I@HHHG@GGFI?GDIHFIFEEHICHBDGGHH'=A)A?HH7EAFI3GDFGH=JCGIF?C=FAHBGHEHBCIEF8D?BBFEHJ:IG@?HIB?HHFI:E1:HHII;DEGHH)@E=IH=@FFIIIHDF@G4GGDHE@CGBIBFFC5CBIH9D@FEGI@FEEJ>HI>GF2HC:EGHIKIFJHG=@GHFEKEHKJA<=FBJHGHAIGIJHHIF9G?GEK?IHGGFFFHKHJK5JIGGI9KK:HK=:KHEFIFEJJFJKJJ3FF:DGE?FJFGK8>KJJHIHH:4HK@KIKCEBHIH=BJHIJI4J=BDEAGJJKJKGJKAFGGKFJAFGKKI>KGGKFI=I@D>C>JIGGGGCJCJIKK4FGIGIEKGE6EDFJH'IJC>IKK8IJICDJ9EFIIEJ?K?A9GCHG=DGHFCG0CG?I:DJKIJJ=HHHH9HHG3/3+6:A>>?13>4+6:=8=67;@5(.=98<5:9/4A>8=;37<@87>B3B@7B?4G-8-CD;E8EDA*;=?A@=9%706D,FIF430.8/C'73GI'7A70;>>6@@A>@:3)'9A-?:.A1=A:=#=*%9>9A0C>@H.EJCAE??2B5A?BDA%<1$DD?>FEB0EE6-I;=H>C=-BFI38@5=33)EI5>D0E?@FD>=F(DE;<7IIFD2@@@B=9@0?E99.BB=GIAF6C54.6:C61/:*7@CAFDDH;'?D'A?37:HD,EIH@5GC>=EEHBDG0;*>GAG?AADC1@CC-@(C1=EF@CH;=>C<6:@A@7>;8E?;DB0EG9@HC@=;6D9DD,64BF-C/GC9ICH1C><G@%CHIGGFH><2J=EGJKEKC;AGEGIIIFGHHBE>JHFJJB4K>GF>?AB;IG<*D,KD=FFK,J2A?%8BFH>K7'HICI)BG)EABDJI-J?C)B?9B8=@B89A4<:?@=':?DF<10:-?@<>:J/?CD4=E=FC9F@FB/=(D48B*=A@/$?/=>2A9)?>=;%DA?.84'?:*DD>>99/EG>H?G=;E(5B,G9F<(7CE)D+F:<'G@=&9+A=0HDCA@*/A8+AACCCDE=G6DD;;1&GB<8@BC(G4&CB>.8>>B/FB.<4;G:.,DIGFFC=F?;F>*EHBF%88>7?F<275>;1?50@E9B;BDA:9:;7F5<:+9+#3(64@7--1=9B8@5E>(D?/C;9>:EEA>>7&#=CCB:9=BCCBB@;;63+9.E2@D>8<2><*B@:D.AE9A8>;=8<;?5;>;?6E>3BCC:D';<;13:*9=<@@8<8AAE*D?C?#:>=:9A7BA.>4==A?/AA=4A?A;=>7;9C?2@<6/%$+(?4'2798,1.)::6637:696>,1*447+2.&67&;:48/026,5*(/9871:-332/%80,32,9026572776361+9:4/508(00/884/325388+'8<;968862/62961/-:29790:10364079>::<,$51326.4-2129:2/+*.497 @rCer/1770/0_1691_CCS TCCGCGCCGCCATGGCACCACGGTGACCTGCACCCGCTCACCGACGAGTACCAAGCTCTCGAGGGATATGGCAAGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACGGCCATGAGTAGCAGCCAAGATCACAACACAAGAGCTGTCAGCCAGAGTCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGCTTCCACTACCTGGTCTCGATCTGGTCACTGGTGGGAGCTCTTTGAAGACATGTGGCGAGGAATACTACAGCGAGCGATGCCAGTCACTGCATCCAGCAATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGTCGTCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGCTGCAGTGAAGCGGCAGACTCGGCCTGCTATCGAGTGCAGGGGACCACAGGCGTGTTTGGGTTCGCTGGCACACAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCGTGGACATCTGGCATGTGGGTGATCCTGTACATCCTGCTCGTGGCTACCCACCCTCTGGACGAGACAGCACAAGCTGTACCCAGCGATCAAGCCGCGCCTACGACTTCCCGTCCCCCGAATGGACACTGTCACTCCTGAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGTCTGCAACGTTCCACGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGCTGAAAAAGTTCAATGCCAGGAAAGCTCAAGGAGCCATCCTCACCACCATGCTGGCCACACGAATTCTCAGCCAAGATTTACTCACAAGAAAGCAGATGGAGTCAAGCCCCAGACGAATAGCACCAAAACATGCAGCCGCCACCAGCCCCAAAGGACGCTTCCCTGCCGCCCTGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGATAAGGAGTCTCTGACAGTGCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAATCGTGACCTAGGGCTGACCTCATTTGAGCCTGAAGCACTGGGCAACCTGGTTGAAGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGCCAAGAACAGCAGCCGATCCACACGACCATCCTGAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTACATCCGGCTCACGCAGTACATTGACGGGCAGGCCGCGCCCCAGCAGCCAGTCGAGGAGACCCGGTGTGGCACCGCCGCGACGGCAAGTGGCAACGTGCACTTCCACTGCCGGGCGCGCCTGTGGCCCGCTGCAGTGAAGAGCTGCGCCTGGTTCGCCGGACAGAGTTGGTGTTTGGAGCCCGACTGCCTCGGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCTGGTGCCTGTGTCTGCAGAAAAACAAGACCAGATTGATTTGTTTAAAAACAAACAAAACAAAAAAACAAGATGACGACGACAACCACAAAAAATTGACAT + S''((,),,(,'')&$*'+&',.+-,)-,,),&,*'(#)$+----+'+($&+$+++)*&#+%%+**%%$(+('($,+,((*--,,+()-.,'()+')'%+**))(-))-+(')))+,'++(*('#$#'%*#&''##&(&&&*&"#'*&$))$++)'),-*)+%'$+)-()(,,%*'('((())+&)---%'*')$&)--(-'+,)+),-**$((-)-+('')''(+&&+,-(+%%)(*--+)((&%#$#$$,*)+*-,*))')+)),(#*,(---+1,.-00'0/*-,)*+(&(00-,0)./-%+-+..01.$%++,0+,.0*010+)%)+%&//1--1-+*,11-0.*+'#1+/$*.+%&'((*+(+&++)0000/+3,35'%323(.0'$144(//,,554+50432610+1.2----((,%346/+056..0)$3(',34535.024'2('#4510-*#/(1*4%%111014-$,0/0$)10%*1+$)*,*0)$#-203/'.02--'.&+-,%+$/,%.14+,(-0014*+0652645%%$%-1,/',4++.')34*3'),&0(,'-.%0'%4/*.52)4/,.20133/-,4+026+03-.)(#)*.-)0/.(&&%('%-./(&%'#')/+/+2150/*1#,''')#,,/-*+45$15261010*)'.)3431&400/3,6**5.+20098<84507-/%42<,;=9;1=169::/8)8+953+<295092.0'7193*9*$/&8:429<:59.>>.:9668&3024>=7<:6,674(921.8#*87:2<1<0/%.6:63:6>77673168651636%1/25863//4/19)$,269;?>3/7:2=9849-*$',46942--%7,-69/6(;6=::59<&8/900$++-(5+-9205=72?87,>3:2?>8>34:8$.591827&8';954=/6/2$61*57):5<74$5:4:852-*$$053.;2,867,2739:73,80'-/,),9:+,:6*0'.46*-0.,*.,)-,+40,.41--4)0453152152654660//0/6,-3-1224/0(1155&3/1,3,.,-&1130#2-,(01/-.415315661+/2256553145636664)555.4133*5&2,44$/&))1./'-(1042+,(34250*225.404'2(13-$+1163(02.)0$256630)602*563043+/6,203,55+++420/255441//1-4.1114,30465,11+5623/0#165046)22146502*+-(/5*1565$-+&))-,1)""$''%&"'*)-1/,)&#)%/&%+&11##)0,%-)/-/*,-%*/,0&.%%/,.%%$#+-+-/0())2/23025.%*.+,4122400()+%23,,*-2.*./*234300.51%0'-1)114)3(/,./004.31601+53.6.1034-/002&2.2(.//+/(336(2+,/43.4565(''#,)*%$)2521650.%)&1-,%44.+,1/'3(,)%*5.22.1'23044)220&-+*(%$.00564-10*45540#/1-(44.-%-/000/0-5/0$+35+/*./.)20320#-/+,/&+/2%32 @rCer/1772/2273_60_CCS ATGGGGAGGGCGGCAGGCTCTCCTCTCGTTAGTGCCCCGTGTGTTTGGGCCCTGTGATCTCAGCGGTCCTGCCCTCGGCCTCCCTCTTCTCCCGCCCCGCCCCGGGCCAGGTGTTCGAATCCCTACTCCAGAACTGGCGGCGTCCCAGTCCGCGGGCGTGGGGCGCCGGAGGACCCGCCCTCGGGTTCATGGCTGCCCCGGTCCGCCTGGGCCGGAAGCGCCCGCTGCCTGCCTGTCCCAATCCGCTCTTCGTTCGCTGGCTGACCGAGTGGCGGACGAGGCGACCGCAGCGGGCGCCGCACACGCTTCGTGTTTCAGAAGGCGCTGCGGTCCCTCCGACGGTACCCACTGCCGCTGCGCAGCGGGAAGGAAGCTAAGATCCTACAGCACTTCGGAGACGGGCTCTGCCGGATGCTGGACGAGCGGCTGCAGCGGCACCGAACATCGGGCGGTGACCATGCCCCGGGCTCGCCATCTGGAGAGAACAGTCCAGCCCCTCAGGGGCGACCTGCGGAAGTCCAGGACTCTTCCATGCCAGTTCCTGCCCAGTCCAAAGGAGGAGGCTCTGGCAACTACTGGCCAGCTCGGCACTCAGGAGCCCGAGTGATACTGCTGATGCTCTACCGAGAGCACCTGAATCCTAATGGCTACCACTTCTTAACCAAGGAGGAGCTGCTGCAGAGGTGTGCTCAGAAGGCCCCCAGGGTAGCCCCTGGAGTGCTCGACCCTGGCCAGCCCTCCGCTCCCTCCTCCACAGGAACCTGGTCCTCAGGACACACCAGCCAGCCAGGTACTCATTGACCCCAGAGGGCCTGGAGCTGGCCCAGAAGTTAGCCGAGTCAGAAGGCCTGAGCTTGCTGAATGTGGGCATCGGGCCTAAGGAGCCCCCTGGGGAGGAGGCAGCAGTGCCAGGAGCAGCTTCAGCAGAGCTTGCCAGTGAAGCAGGGGTCCAGCAGCCACCACTGGAGCTGAGGCCTGGAGAGTACAGGGTGCTGTTGTGTGTGGACATTGGCGAGACCCGGGGGCGGGCACAGGCCGGAGCTGCTCCGAGGCTACAGCGGCTGCACGTGACCCACACAGTGCGCAGCTGCACGTTGGGATTTTGTATGGGTGGCGCAGGAAACCAATCCTAGAGACCCAGCGAGCCCTGGGGAGTTGGTACTGGACCACATTGTAGAGCGCAAGCGGCTGGATGACCTTTGCAGCAGCATCATTGACGGCCGCTTCCGGGAGCAGAAGTTCCGCCTGAAGCGCTGTGGCCTGGAGCGCCGGGTATACCTGGTGGAAGAGCATGGCTCGGTCCACAATCTCAGCCTTCCTGAGAGTACGCTGCTGCAGGCTGTCACTAACACTCAGGTCATTGATGGCTTTTTTGTGAAGCGCACAGCAGACATTAAGGAGTCAGCTGCCTATCTGGCCCTCTTGACGCGGGGCTTGCAGAGACTCTACCAGGGCCACACCCTACGCAGCCGCCCCTGGGGAACCCCTGGGAACCCTGAATCAGGGGCCATGCCCTCTCCAAACCCTCTCTGCTCACTCCTCACCTTCAGTGACTTCAACGCAGGAGCCATCAAAAATAAGGCCCAGTCAGTGCGAGAAGTGTTTGCCTGGCAGCTGATGCAGGTGCGCGGAGTGAGTGGGGAGAAAGCAGCAGCCCTGGTGGATCGATACAGCACCCCTGCCAGCCTCCTGGCCGCCTATGATGCCTGTGCCACCCCAAGGAACAAGAGACACTGCTAAGCACCATCAAGTGTGGGCGTCTACAGAGGAATCTGGGGCCTGCTCTGAGCAGGACCTTATCCCAGCTCTACTGCAGCTACAGCCCCCTGACCTGAGCTTATGCTGTGAAACAGCCCCCAGCCCCCATCTGTACCCCCACGCAGGCTAGCCAGCCTTTTTAACAACATCTTTTGTGGTAAAATTAGAATCTAAGTGTTTGCAGCCATATGTGTTATGTAGAAGATGCCTGGCCCTGGGGACCTTGTGAAATACGCAGGAACCAGGGATACCGTCTGGACCAGTGGTTTTTAAACAAAGCTGCTTAGGACCTGGGATTGCCTAGTCAGGGAGATGGAGTCAGTGGGGCACTGCAGCTTTGAATCGATTTTATGTCATCAGTTGGTCCTCATCAAATAAAACTTCCTTAGGAGTGCAGAGGGCTCATTGGGAAAATAAAATAATAAAAATAAATAAACTTCCTAAAAGAAAGCTTG + +97>55>;@4DC:?>C?;<9>C:527A@>:=5C+6>1;>C?)CB'BA%=;2?===6D;B=E@8+;9?3C7=?;+DCD;CA<<3<;@=2@ACF1=C(@*CG@DB7-D@>.BBA5B:77A>;?@@B4=A;3>A;FF1C84>3ECAEG?=9C1=;;<<==6C:><0>D??BC<6>=?7B>9D7B=<=7CA<<=A+6<>??07CA:ED87:/<;;C@=D@A8<1?78?4==A7>CCC<::A?;A659>@>4><:;A2<9(884C;8C;D;>3@>)=28;B?;B@CC<<8B?D<>9:?51;A5A?=?;=@A9F;AF::;6:<8375AC6=57;:B4@:C<@A=E:B@??>+:CB@??>A@A@B;44;=2BC7D2G>FDD56AFDB>4E7FBFE2;6DE>C79B?F@@:14;@=>:>::92;;3.7;?=A.:6-=@*A7???<;7=C<<9+6@A37A5?=?/?5C?9<67AC=>=1=?2<;A583?>?:;?2>18>:?6>5@<>A/:<>7/12/2509:==778;;@?@:7>8AAA?7:@1==89<8963656479';C=?A@=8@<=@9?C=C7>B=;?<=<894*15;=975:99169A3A8=A;<6<9<7&+**.232#479(82=/9&:8A=<>=409260=5&/9@AB?@CB3.0<@<=;:57?=4<5*:A>838<5.=?@:?B@=?3:<%588=,;=B=5<4;9?7>>15-<@;B@=7:?=?15/A/92;:,4?456.;9@A9B;:;A==B>@0<7;4:8344788?=C=5=6>=@9<@B<22;:4788782B8>7A=CB@C?>6?==;=9C3/C1==@.::9:::5>><6=A::<>8>3=B62365?:7C9=92=3;:9?<>B4393<8?AA47>5;817;@A6?;@87>;;>=?@?8::08:;>@@8AC??=@=6@6@A9?B<>>;=>@8B<BA=;4>9A-=:9:>A)A>;6B>CC4?;;?2?85?:A?:755=981@;;B<;6=>B@1A3?CC5:9=2C;>==8A<=><438?%<3A:ABB697<@:?@/BB?;69985:39;:=@A>B?:/:566<43;85.5317:86:788=+*.:9:84*8;4=9>:76;4::/9::5:64%030;?69?9=92<7030762;;=624012<<749294=8999'9<7<2923.8.,9968867:.1::>6$77996.45;2<:7=16983,*+789&/3:3=1:9896+8=5:5788+)&/431550678/34=<084>>5/36>:>89(:7<9:<-;.9;<2<41-6378.7:60&38:;63;88>:3698<:06/05*9;=:7*<6:?88886=9558>412:769,=9:7<>=+0:>>>;-69;=93/9594(8<686?;447<:74=?=;76:&;7><4<329732&23947::1-;9798'9<>?29<<9>6>;<>=613998<93.<;865=<9<4=9?<4>6=<9<<>;+5?4=/87;31)9<;958=892>;<97*1.6<267=:;+7<325192648;,?;7787,6:958>51:1593416'6?99:;8.76:77:82;162.5/=:85>:/8=3:5:863/.51,6777350256-::8<=:68>65:15-+::15575;>9772288;983%116;9,=:79>6-2838$:797577927;62343#4?KJH=HJ:KIKJ;J=JKAABBK=GK;FIJJHFI@F2F$??FJK%JIJ;;CGKK?JGKIKF@CGCHKHGK:I9HFHBKG>GHH:JJKJH;KKIKKJK:JK3@KK3K=KKBKK/CK:JHBKKK5;CJGCIHJKKKHK$EFIIGJHIIIH4FK-JDJJ;F>J1EHAHICCH5IIIIK4-JDE0G>IH9BJ>B>DIFKE;@@GH4KAGJCIEEHIIGHEEHGGHK&KD?;E>DFGK6FFC6@FIGCDEGIGGKHII=KK<9CKK-EKK2E2(EK=JGKI9J6GIGKIKJIJJKKFJJKAII>GJI:H@D<3E%BFJKKD>IKDGCC1D3H:DK9H?EJ=KFFEJAK?JKKCD>J9?BEK@KKI/IK%HK-JF?KKKJH-EHGG@DKJK;J;KHJCHKHDIEJK?IH.BKIH32K5G7JIEA8>:@?==GKI@IG?J8B<:BF'7BAG9GFBJIG7B>;@&:GFFF7FJACGHHJH7HCF9E@J,JIDHCAKKJHJKI=9E7HHBFK>HKJK;KKD:;>I8KKKK1H>KKKJGIKH;B%C;GFGJK=KJ3GK?II0G@HKKIKEIJ>JI@,3I>:HHJIEI:KCHKHCKGJKKB4J=EKIK>KJKGDBJ?0EJIKFJFFII2EHJGGKHJ,>J3E8EFDF@FFF*JEDGHC;DIGDIH1E=BB=GCAEIJ+@BF:5@IHKF(K0KJHEKKK7EJK4BGJKKKKCI?K?J1F?HHDGKKKKIKHCIFFIHJ6HKFJK?4@HKJ.H8KJJK?IIKKJ90:>K1@JK52:0H)GIKK@FB>D @rCer/1776/2140_77_CCS GCGCCCACCTCGCCGGCTAGTTTTTTAATGTATTTTTAGTACAGAACGGGGTTTCATCCCTGTTAAGCCAGGGTGGTCGCGACCTCCTGACCTCCTGAACTCCACCTGCACTCGCCATCCAAAGTGACATGGGATTACAAGTCGTGAGCCCACCACGCCCGGCCCTAGTTCTGGATATTTCTTAAAAATGGCGAGTTGGCCTTTGAGGAGCGCATGACAGTGCAGAAAATGGATGTAGGTGGGCGTCGGGTTCTCTTCTTCTCAACCTAAAGCCCTTACTTTAGGGCTTATAATAAGCGTCTGAGGACAGGCATGCTGGGTGACTGTTAGCAAATACGTAATCTGGAGGCCTCCATGAATCAGAATCTTCATTGGATAAACACGTCCCTTAGTGATATGTGCGCGTTAACGTTTCACAGAAATGGCTGCCATACGCTTCCCAAGATTTTAGTGTGTTACGCAGACAGTGTTTGACATTGCATATTTGGCATGTGCAGAACGGTCGGCCTATACTCTGCAAACTAATGAAGACAATTAAGACTCTGAGACTTGTGCAGTCTAACACATCTGGACTATTTAATGACCTCTATAGAACATCCACTGGCATCACCATAATCACAGAGATGTGTGATAAAACGAACAGTTGTGATGTGGGGTGCTATAAGGTTAGGAAAACCTACGGTGAAACATGGGTGCATTGAGGAGTGCAGAAGCACCCAGTTGAAAGGTGTAAAAAGAGTGTGTGTCGGTAAACCTGCAGTGATGGTGGCACCCAAGAAAAAGGACGGGGGAATGGTGGTGATTTTCAACGCCGGAGATGGGCCATACGGGCTAACATCATAAACTCTCAACCTTGGCATCCCAACAGACACCTCATGCAATCTAACAATGAGAACACCATAATCTAAAAATAAAATAAGCTCAGTACAAAGCTGACCGTTGGTAGTCAGTTCCCAAGAATAAGACTCTCCAATTCTCGATGCCCTAAGCCATATGACGTGTAAATCCCTATCTAACATATGAATCTTCGTTCATATAGCACTGCACAGCAACTAGTGGCATATAAGAAATGATGGTTATGAATCTGAGCTGTGCGGTCAGGATACAAGATTACTGTAATTCAAGCCATCTTTGCTACTCTCCCTGAAAAGCACTTAGCTTGGGGAAAAACCAAAACTATGTGCTGAGAGCATGTCTCCAATAATCAGCTCTAATTGGATGAGCGTCCAATAGATGAAGAAACGGAGCTTCCCTGCTGGACAACATAACATAAAAAATCAAAAAGAATCGAAAGAGAAAGCCAAATCACAATGGAACTTCCCATACCATTCCAGCAAATCATGGTCAGGCGCTTCAAGCCATGCACTGCAGCTGCCTGCCTTAAGAATGAAAACTTAACAATAAGCAATATTCATCGAGAAAACTGTGTTCCAGAACCATTCAGCTACAACAACGGCAGTTAATTCAGGGACTTCACATATCTGGACACGTGAGATAAACATAGTAATACTAGTTTTAGAAAATTAAAGCTTAAAATATTTAGAAACGAACTACTTTGTTATGCAACATATAACAAGTAAATAACAGCAAGGGGTCCGACTGCGTGTGCGCGGAGATTATAAAGGTAAATCTGTACCGACCATAACACAAAGCATAGCTTGACCGTAAATATTGGCATTTAGAGCAGATGGTTTTTTATAAACACTCAGTTTTTGGCAATCATCTTGAAGGCCATACCATAATAAGTGTTTAGCGGTGCGCCTGTTAATAATACAGCGTTAATTGTAAAGAATTCAATAACCAGTGGACAAATATAGAAGCCGGAACTTTTTACTCAGCCAGAAGGAAATATAATAAATAGAGAAAAAGGGAAACAGAAGGAGGTACAAAAAGTGGCACATGTCTTCTTTGTAAATACCTAGTGATTTACCTTGCCCAAGAATTTTGTTTCTTATCCTGAACAACTAAGGAACTTATCTCACCGAGAAATCTCTCTAAAGAACTGCAGCCAATCCTTGCGGCTCCATTTGCTTAACTGAAAACTAAAACCACCAAAAGGGAGC + 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@rCer/1777/25_2090_CCS ATGGGGTTGCGCAGTAGTGCTAGCGGCTTCGCGTTTGGTCCTCCGACGGAGCAGCCGCCACTGGTGCTGAGCTGCTCGGAGGCCCGTGTCGGCGAGCTCGTTGGAGCTTGAACCCATTGTCACCCCTCCGACTCACCGGCAAAAAAAAAAAAATGGTTGAAGCAGATCGCCCAGGAAAGCTCTTCATTGGTGGGCTTAATACGGAAACAAATGAGAAAGCTCTTGAAGCAGTATTTGGCAAATATGGACGAATAGTGGAAGTACTCTTGATGAAAGACCGGGAAACAACAAATCAAGAGGATTTGCTTTTGTCACCTTTGAAAGCCCAGCAGACGCTAAGGATGCAGCCAGAGACATGAATGGAAAGTCATTAGATGGAAAAGCCATCAAAGTGGAACAAGCCACCAAACCATCATTTGAAAGTGGTAGACGTGGACCGCCTCCACCTCCAAGAAGTAGAGGCCTCCAAGAGGTCTTAGAGGTGGAAGAGGAGGAAGTGGAGGAACCAGGGGACCTCCCTCACGGGGAGGACACATGGATGACGGTGGATATTCCATGAATTTTAACATGAGTTCTTCCAGGGGACCACTCCCAGTAAAAAGAGGACCACCACCAAGAAGTGGGGTCCTCCTCCCAAGAGATCTGCACCTTCAGGACCAGTTCGCAGTAGCAGTGGAATGGGAGGGAGAGCTCCTGTATCACGTGGAAGAGATAGTTACGGAGGTCCACCTCGAAGGGAGCCACTGCCCTCTCGTAGAGATGTTTATTTGTCCCCAAGAGATGATGGGTATTCTACTAAAGACAGCTATTCAAGCAGAGATTACCCAAGTTCTCGTGATACTAGAGATTATGCACACCACCACGAGATTATACTTACCGTGATTATGGTCATTCCAGTTCACGTGATGACTATCCATCAAGAGGCTATAGCGATAGAGATGGATATGGTCGTGATCGTGACTATTCAGATCATCCAAGTGGAGGTTCCTACAGAGATTCATATGAGAGTTATGGTAACTCACGTAGTGCTCCACCTACACGAGGGCCCCCGCCATCTTATGGTGGAAGCAGTCGCTATGATGATTACAGCAGCTCACGTGACGGATATGGTGGAAGTCGAGACAGTTACTCAAGCAGCCGAAGTGATCTCTACTCAAGTGTCGTGATCGGGTTGGCAGACAAGACAGAGGGCTTCCCCCTTCTATGGAAAGGGGTACCCTCCTCCACGTGATTCCTACAGCAGTTCAAGCCGCGGAGCACCAAGAGGTGGTGGCCGTGGAGGAAGCCGATCTGATAGAGGGGGAGGCAGAAGCAGATACTAGAAACAAACAAACTTTGGACCAAAATCCCAGTTCAAAGAAACAAAAAGTGGAAACTATTCTGTCATAACTACCCAAGGACTACTAAAAGGAAAAATTGTGTTACATTTTTTAAATGCCCTGTTAAGTTTCCCTCCATAATTTTTATGTTCTTGTGAGGCAAAAAGTAAAACATGTTTAATTTTATTTGACTTTATGACATTGCTTTTCAACAAGCAAATGTTCTTGTGAGGCAAAAAGTAAAACATGTTTAATTTTATTTGACTTTATGACATTGCTTTTCAACAAGCAAATGTTAAATGTGTTAAGACTTGTACTAGTGTTGCAACTTTCCAAGTAAAAGTATCCCTAAAGGCCACTTCCTATCTTGATTTTTCCCAGTAAATGAGGCAAGCAATTCTAAGATCTTCCACAGAACATCTAGCCATCTAAAATGGAGAGATGAATCATTCTACCTATACAAACAAGCTAGCTACTAGAGGGTGGTTGGGTATGCTACTTATAAGATTTCAGGGTGTCTTCCAACTGAAATCTCAATGTTCTCAGTATGAAAACCTGAAATCACATGCCTGTGTAAGGAAAGTGCTATTCACCCAGTAAACCCAAAAAAGCAAATGGATAATGCTGGCCATTTTGCCTTTCTCACATTTCCTTGGGAATCTGCAAGAACCTCCCCTTTCCCTCCCCCAATAAGACCATTTAAGTGTGTGTTAAACAACTACAGAATACTAAATAAAAAGTTTGGC 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@rCer/1778/2079_57_CCS GGTTCGGTGAAGGGAAAAAAAAATCCAAACATGCAAAATACCCCCCAAAACACATGACCTTCTTTTTCATTTTATAATCTAGACTTGTAAAATTTTTATAAAATACATGATCATTCTACACAATACAGATCTTCTAGAGCATTTCTAAAGGATATTACAGTTTTTGGTCTTAAGGAATAAAGACTAAGATGGAAAAGGAGATGAAAACAGTGAAATCTGAGAAAGCAATACTCTCTCTACACACAAGCTGTAGTTCATCCAGTCAAGTTAGCGGTTACAGTTCAGTACATGATTTTCAAGGCAACTAAGAAATCAAGACAGATATTTCCCTTTCCTAGAGTTAACAATTCTTTTAAAAGTTCCGATGTATCCATAAAGGAGTGCTGATTTTTGTGGGGTTTTTTCCAAAAGGAAACAAAGAATAAATAGGGGAAAACAAGTTTCCATCCCTAAAGTCACATACACAAGTTAAGTTAAACTATAAGCTAGTTTTAGACTACCCAGTGAAACAGAATTGTTGGTACCATCTGAGGCAGATGCTACCCTCCCTAGTCAGTTCAAAACATGATCCAGTAAAACAAATACACATTGTTATGCCTCAAACAACTATAAAGCATTTCATTATTCTTCAAATATCATGTTTAATTAACTCCTAAGGTAACAGACTTCTAGAATGTTGTATCTTAATGGTGTACCTGAATCAATACTAGCAACAGAATGCAAAATTCAAAACTACAATAAAGGTAAAATCATCATAAAAAGAAATTCAATCCTTATGTAAAAAAAGGGAGAACTGAGGGTGAAATACTAACACCAAATGTCTCCCATGTACTCTGCGTTGATACCACTGCTTAAGCAGTGGTATCAACGCAGAGTACATGGGATGACTCCAATACGCAAATCCAACCCAATCATAAAAATAATTAATCGCTCCTTCATTGATTTACCCACCCCACCCAACCTCTCCATATGATGAAACTTTGGCTCACTTCTTGCAGCCTGCCTAATTTTACAAATCATCACAGGCCTACTCCTAGCAATACACTACTCACCAGACACCTCCTCCGCCTTCTCCTCAATTGCACATATCACCCGAGATGTAAAGTACGGCTGAGTCACTCGCTACCTCCACGCCAATGGTGCCTCTATACTCTTTATCTGCCTTTTCCTACACATCGGTCGAGGCCTTTACTACGGCTCATATCTCCTCCTAGAAACCTGAAACATTGGCATTATACTCCTTCTTATAACCATAACAACAGCTTTTATGGGTTATGTTCTTCCATGGGGCCAAATATCATTCTGGGGAGCAACAGTAATCACAAACCTACTATCAGCAATCCCATATATTGGAACCAACCTAGTCCAATGAATCTGAGGAGGATACGCCATTGACAGCCCCACCCTCACACGATTCTTCACCTTACACTTTATCCTACCCTTCATTATCATCGCCCTCACAACCGTACACCTACTATTCCTACACGAAACAGGATCAAACAACCCTTGCGGAATCTCCTCCGACTCGGACAAAATCGTCTTCCACCCCTACTACACAATCAAAGACATCCTAGGCCTAATCCTCCTTCTCTTTATCCTAGCAACACTAACACTACTCTCACCCAACCTCCTAAACGACCCAGACAACTACATCCCAGCCGACCCACTAAATACGCCCCCACATATCAAGCCAGAATGGTACTTCCTATTTGCATACACAATCCTACGATCCATCCCCAACAAACTGGGAGGCGTACTAGCACTCTTCTTATCAATCTTCATCCTAGCAGCCATCCCCATACTTCACAAATCCAAGCAACAAAGCATGATATTCCGCCCACTTAGCCAATTCCTGTTCTGATTCCTAATAACAATCCTATTAACCCTTACCTGAATTGGAAGCGAACCAGTAACTCAACCCCTTACCACTATCGGCCAAGTAGCATCCATAATATACTTCATTACAATTCTAATCCTAATACCACTAGCCTCCCTGATCGAAAACAACCTACTCAAATGAAC 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@rCer/1780/24_1729_CCS TGGGAGCCAGGCTGCGCAGTCCGACACTGACTGGGCACAACGGCGACGCTGCTGCAGCGGCAGAAGCAGAACAGCAGAGTCCTCCTGCTGCTGTGTGAGACACGTGGCACGGGCAGACGTGGTCTGTGACACTGCACTGGTTTCGTGAAGGAAGCTCCAGGACTGCAGATGGCTCAGCTGTATCAAAGTCACGAAATACTTCTCTTCCTTCAACTTGATCTTCTTTATCCTGGCGCAGTGATTCTGGCTTCGGGTGTGATCCTGGCGACAAGAGCAGTTCATCTCTGTCCTGCAAACCTCTCCAGCTGCTCAGGATGGGGCTACGTCTTCATCGCGTGGGCAGTCACCATGCTCATGGGCTTCTGGGCTGCATTGGTGCGTCAATGAGGTCGCTGTCTGCTGGGCTGTACTTGCCTTCCTGCTCCTGATCCTCATTGCCAGGTGACGGCGGGCCCTCTTCTACTTCACATGGGCAAGCTGAAGCAGGAGATGGCGGCATCGTGATGGAGCTCATTCGAGACTACAACAGCAGTCGCGAGGACAGCTGCAGAGCCTGGATACGTGCAGCTCAGGTGAAGTGCTGCGCTGGCAGCTTCTACAACTGACGGACCACTGAGCTCATGAGTCGCTCTGAGGTCACTACCCTGTTCTGCGAAAAAGGGAAGAGGACAACACCTTTCCATGAGAAGGCTTCTGCGAGACTGCCGGCAACAGGACCGAGTGGCAACAAACCTGAGACTGCCTGTGTACAGAAGGCTGCATGGAGAAGGGCAGGCGTGCTGCAGGAGAACCTGGCATCATCCTCGCGTGGCGGGCGTGGCTGTCATTGAGTCTGGGATGGTCCTGTCATCTGCTTGTGCCGGCACGTCATTCCGAAGACTACAGCAAGTCCCAAGTACTGAGCAGCTGCTGTCACACCTCCTGCCGCCCTGACCTCAGGGCTCCCAGGGTCTCCTGGCTCCTCCTCAGGCCGCTCCACCTCACTGCAAGAACCCTTGCCACCTGACTGAAATAGGGGCTTTCTGGGCCTGGCGATCTTCCTGCCTATCGCTGTCAGCTTGAGCCTGCTGTTCTATGGTTCCTCCGCTCACGCTCATCAGGGTCTCTTGCAATCAGAGAAAACGCTCCCGCAGCGTCCTGGCGCAGGTGGCTGGACTCTACTGCCTCAAGGGTGTGTGTATTGTATAGGGGCAACTGTATTAAAATTGGAGGGGGGCGTTAGATAAGCACCCTGGCTGTCAGGAGACTGCTACTGGCGGTCAACTTATTTCCACTATCATTTATATCTTTGTTTTTTCACAATTATATTGAAGGCAGTGGAAGGGTGGGTTTTACTGATATTAAGGGTAGCACCCTTCCCAGCTGATGCAGTCATCTAGACAGCTCAGATTAGCCTGGGCATGCCTGGGACAGGCTTAGGGGAGCTGGTCGGAGGGTCTGCTGGGTAACGAATCTGGCTTGGCCTGAGCTGCTTAGGAGGTGAGTCTTGGGGATGCACAGAGCTGGCCTGTGTTTTCAGGGTCCTGAGCTGTCCAGGGACAGGAGAGAGATGGCTTCTCTGGAGAAGGTGGCTGGCCTTTCTGGCAGCTGTCTCTGCCCTGGGAGTGGGTGTGAGGCTGTGCTTGTAGGGGGAGACGGGAGGGCTCTGTGTGCACATTCTGTAAAACACACTCAAGATTCTAAGACTATTAAGAAGATTTATAAC 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rCer/1781/0_1278_CCS TGCTTGAATCCGGGAGCCGGAGGTTGCATTGAGCTGAGATCATGCCACTGCACTTCAGCCTGCCAATCAGAGCGAGACTCCGCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACAGCACTGTAAGAAAATACCACACAGCAAAGGAAAACTTATTTTTCTGCAAGGTGTCTTTCAAAGATAGAATGTTTGAAGCATGTTTCCTGGAGATTGTGTGGATTGAGGGTGAGCTGGCTGAGGCGTCGTTCAAGCTGGGGGGTGTAAGAAGCACGTGCAGCCACAAAGAGGCACCTCCTATAGTCAGCTAAGGGCTTCCCTTTCTGCACCCAGCTTTTGGTGAAGGGTGATTTCTGTTAGACAAATCTGTGCTTCAGTCATAGATGTTAATAGAGGAAGCAATTTTCCTGCTGCAGATCCCTGAAAGAGAGTTGCTGAAACAGTCTAGTTCCAGACTCAGGGGAGGTCGAAGGCCAGTCTGTAGAAAGGCTGAGGCAATGGGGAAAGACTTGACAGCTAGTTACATATGCTCTGACATGGTACCCCCATGATGGCTTCCAGTGACACATGTGCTGATAGAATTTCTAAACCTCTGGAATTTCCCTGCTGGTTAATTTCTGTGACCCTTGACTGTACAGGGTGACCTGATGCCAGATGCTGTGGTCGGTGATGAGAACTAGAGAACTTGCAGTGTGGAGGAAAGCTGTTGTGAGGGCACCCAAGACCCCTGTGCTTCTGCAGGCCAATTTCCTGAAAACCCCCTGTTAGAAAGGTTGGGTTTTAGTGTGACTTGCTTGAGCAAGAGTCCTTGGGAGAGAGATTTTGAGGTATTAAATTTAACAGTAATCTCCAGAGCTAACAGTGACTCCATTCACGGCTTAGTTCCGCAAGTTCAGATGTAAACTTAGAGTCTCCTTTGTGAAGGGTTTGGGTCTGAGCTGTATAGTACGGTTCAGTGGGTAAAGCCAGCCCTTCATCCTCATTGATAAGATAACCCTCTTTTAAATTCACCAGACTCATGTTCGATACATTATTAATAGTTGAAATTGTTTCTCTTCTTTTGTATTTTCCCAGTTAATAGATTGGCTACTGTTTCCCACAATGTTTATAATTTTTCAGCTTTTTGTAAACTTAATTACTTAATTTTTATTTTTTTAAAGCTTGTTGCGGTCTAAATGAGAAGTTATTTTTCAGTGCAATAATGTTTTTCCGAGCTTCTGTTTAATGCCATCCCAATGTAGTTGTTGTTGAACAGAAACCAAAATAAATTTCAAAATGT + S'##'(%+)*,(,+$'&*('.&..-,*$&(--,.))10/(/*//%+,,++1+.,1'*-'*00'''.+$+0,.1+-1.(%(,,0-,$.//0.../--)'))),+++.-/--,/0/-01.&-0(/0'#'*$$/1,)--,%+'*'(,*,-*)#'-,+)*+#,--%',.-$/)-(*''$20,'-0))/+*,20*(-*.'//--*,++//.*./+)/(*)**'+((%,0.,',%-,()+(/-&.1./0/$*0*1112,%/),01/,*,.))+%/-3.2+003../4/.&+(($'.,-*11+0&.+%*+.2+20,3(0353/*-)(01/102*(,%+2/&--.'+)')0)+,01/.33312.2/1*)*/143,/1-2.51/30302)---2'.,4(,20150204.3&11++/+4.400+2'$+14/0&,*4230/.33,+045563/'335*(413.$2*+3,'+.20-33521212.2153*,,*-,$,2)01')&&0/$/&%.-0.131.2&+*',.*(1-*)43321.*246420300(.1/,*./10(0.0/--1',/411.1.//.)$.03.0.%'30./%.++*#.0263+301'0%53*--+2*1,*&+.2%((..'(-,')('+10.10$.,/*',(,&(-+,-','+$)()*)'&,%0#)$#+,'/0(0,2,(,++110,'--0-,)'+-,)'+&++/.,+$%*)&$"&%'%"$&''*&"$%(,/.*%$%),+++/*/0$%%)0).0+#),("++-,.,*,/,&),-/$$)(.#+,,#)--0(.*,/11+*'*-*%$,(.-,0'+$&&$(*(&%$$(',*()))$(+#%)+0.'(*)((%)-,$)0+-,*+.(+)*,*$''/0,-,0+&##$-&)'#&+*-)+,*,$&)+'((*%$&)%%(%'%'%*,(+(-+*+,()&-(',,(')')&(%&'(($%'##&'%"$%%$%###$#"#&&$#&"%$$##"###$%$%#%(&$$$""$$#%$$%"""""#$#%%&%&#%$""##""$%#')+,-,,()+(''%*'&%('(+&$%$+,*.---*)+**(),'$%()(%(+++$&%&&#(&$%%(*)'%##$'%$$&#&')'%"%'&*'$$$*)$&##"$'''(&%$'('')&#$)(%#&',%)'('&"'$&'&&'+)&'%)%(*'*&%%%(%&$(*'$%+&'((*,,.+$($#*,##(*-('$(((*++%(*)((,('#&##))*'%'''*(&&%&%%(%&#%+*),,(-+-,&)++.&(''*)++&)**&)'%+(& @rCer/1782/25_2177_CCS ATGGGCAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCACACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + :7';A>:;?4?@F@G9>?5A:?:@1/?FD84C7<=A>GABB:9=A=;EE>7A>@==E@HF:AIAIBA7E?<@GF@9FB>A.(CFAC7@F9C@B@GICID/IDHAAB>GF>FJFIH?CJEKIEKEKKGHHDED4FG8KJAFDFKJD7FCJIIAJ@HI@FF;>DCC=E9DAI1A5@;:BGC?9<=GB;DJAGAH=IK=D=KHIJH<@FGJ?F(BG:6BB:C9<@DAK9JEKJ>EE=HB8EAD>GC:FIHH4JCH@FEIHJII/GJIJCIEJH?9AE7JK2HDIFDD@JIAFCC*FACHF6A@;>ADDDDGJ&E?BGDKI4.$B?>H3IF:CDAI?2IHCJIIKKDKGBG>9;DDFBD:HADI@?IJHAJHHG@H3GEB1EFJIC?FIEF>89GKH-GFJD:CA?4JIIE8IG5ACIAHFIBJD4FJ?5BA>IGGIHFJHJ/JDAB6DGC6JEIF?KGIKGKEGIJ@KII@FH?DCJD:GFJCIEHF0KJJJEB0HFIIJKAKJEKKJBA9@HE?HKHIHCGEH4JCH?=AJH:EBK=FF9GAJHCD@FGFIJBII.EB@2EEHDDHF:,GGH?HJI>JJ>J%?GD6ABF%EF=EADC@IGBDIEDJEF9JH0HHJFJJJGKFFHJKIEKFFH9@?HHAHGHAK:KIG1:I82H<:B>C=*:EJDBDCDF5>E@<5E@HHK8H6CF0$HGHHIIHIFDEGKIIHIIHHCGK:IHHFF@I?GDDKD9FIHCEKFJ>HFB+FEI;.EAEGJJJFFFFIG?HJAD;9@JK@KKD=GJ@EGJ<>>4JDAA+KKJIHH@?ADG/KBKKK:KKBKG?EH@CH@FGDF9GIHECB+E;HAA@;AFE2G>6HA@*JJHDD:DFJJ?K@JFB@E8,DJFGHGJFKKEJKGK?DHJDGDJHDKJIHI?JHFIEJFDJGIJJKJKJDFIKGCJ?KJI;HJHDJ9-KD:DGJIFFFBJJKKKHKI/KKA>AK2GBFC?IKJJE1HAFJKJAGFKIIDJKJ@GIJBFKK:H7C?CIHAKGEHJJHAI9HBEGJJF2KKJKFDGJFKEG3F1KJKGGBKH/CJDKHKIJDEGDGG?KGC?A?ABBJHI4BKIH>FEHKJIF6H>=IC=(JKJDFIEJI1KKC@KKK@==D?A?D:D,HG98CHKKJKI2CGDEHKJJK8KK>FBJHF179H=@CD;JHFFI=KKEGHJID@JIEGJF/JJI7DB@G1FJJBIKD@DFJ7KCEE=GA>@-9BEIDFH(HDKKDHJJJJI?HH-GCKHIBJJKKHKCE%AEHG8FJCJIG6I:A:ABHBJIJKJGKJFE>=:A1E;HA@@D?=:GK2ED1AG?4)BCGA?9F:4EB8JKKHKKKKKD>F9?KJG6KJJ7H=@G8@*FEJGJ6GJIHJ8GBKDBI5KI1JIHJIKJKKJJKKHKJEIIHF9B?KJEKGFIGKKJFKJKGGCEG9GHKJ@DECFGD1FHHCDJH4IKH6KJF>HF @rCer/1795/1735_55_CCS ATGGGAGTAGCAGCAGCGCCGGTCCCGTGCGGAGGTACTCCTAGCGGTGTTGTTTCTCCAGCAGCGCAGTCTCACTACAGCGCCAGGACGAGTCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGAGAAAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAACCACAGAAGAAAGTTTGAGGACTATTACGAACAATGGGAAAGCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAGATCAAGAGGATTTGGTTTTGTAACTTTCTCATCCATGGCTGAGGTTGATGCTGCCATGGCTGCAAGACCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAAACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAGGGGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGACATCACCTTAGAGATTACTTTGAGGAATATGGAAAAATTGATACCATTGAGATAATTACTGATAGACAGTCTGGAAAGAAAGAGGCTTTGGCTTTGTTACTTTTGATGACCATGATCCTGTGGATAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAGTAAGAAGGCTTTGTCTAGACAAGAAATGCAAGAAGTTCAGAGTTCTAGGAGTGGAAGAGGAGGCACTTCGGCTTCGGGGATTCGCGGTGGCGGTGGAAATTTCGGACCAGGACCAGGAAGTAACTTCAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTATAATGGGTATGGAGGAGGGCCTGGAGGTGGCATTTTGGAGGTAGCCCGGTTATGGAGGAGGAAGAGGAGGATATGGTGGTGGAGGACCTGGATATGGCAACCAGGGTGGGGGCTACGGAGGTGGTTATGACAACTATGGAGGAGGAAATTATGGAAGTGGAAATTACAATGATTTTGGAAATTATAACCAGCAACCTTCTAACTATGGTCCAATGAAGAGTGGAAACTTTGGTGGTAGCAGGAACATGGGGGACCATATGGTGGAGGAAACTATGGTCCAGGAGGCAGTGGAGGAAGTGGGGGTTATGGTGGGAGGAGCCGATACTGAGCTTCTTCCTATTTGCCATGGGCTTCACTGTATAAATAGGAGAGGATGAAGCCCAGAGGTAACAGAACAGCTTCAGGTTATCGAAATAACAATGTTAAGGAAACTCTTATCTCAGTCATGCATAAATATGCAGTGATATGGCAGAAGACACCAGAGCAGATGCAGAGAGCCATTTGTGAATGGATTGGATTATTTAATAACATTACCTTACTGTGGAGGAAGGATTGTAAAAAAAAAATGCCTTTGAGACAGTTCTTAGCTTTTAATTGTTGTTTCTTTCTAGTGGTCTTTGTAAGAGTGTAGAAGCATTCCTTCTTTGATAATGTTAAATTTGTAAGTTCAGGTGACATGTGAAACCTTTTTTAAGATTTTTCTCAAAGTTTGAAAAGCTATTAGCCAGGATCATGGTGTAATAAGACATAACGTTTTTCCTTTAAAAAATTTAAGTGCGTGTGTAGAGTAAGAAGCTGTTGTACATTATGATAATAAAATAATTCT 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@rCer/1801/24_1912_CCS ATGGGGCTTTCAGTCGGCGCTGAGTGGTTTTTCGGATCATGTCTGTGGCTCCGCGGATTATAACAGAGAACATGGCGGCCCAGAGGGAATGGACCCCGATGGTGTCATCGAGAGCAACTGGAATGAGATTGTTGATAACTTTGATGATATGAATTTAAAGGAGTCTCTTCTTCGTGGCATCTATGCTTACGGTTTTGAGAAGCCTTCCGCTATTCAGCAGAGAGCTATTATTCCCTGTATTAAAGGGTATGATGTGATTGCTCAAGCTCAGTCAGGTACTGGCAAGACAGCCACATTTGCTATTTCCATCCTGCAACAGTTGGAGATTGAGTTCAAGGAGACCCAAGCACTAGTATTGGCCCCCACCAGAGAACTGGCTCAACAGATCCAAAAGGTAATTCTGGCACTTGGAGACTATATGGGAGCAACTTGTCATGCCTGCATTGGTGGAACAAATGTTCGAAATGAAATGCAAAAACTGCAGGCCGAAGCACCACATATTGTTGTTGGTACACCTGGGAGAGTTTTTGATATGTTAAACAGAAGATATCTTTCTCCAAAATGGATCAAAATGTTTGTTTTGGATGAAGCAGATGAAATGTTGAGCCGTGGGTTTAAGGATCAAATCTATGAGATTTTCCAAAAACTAAACACAAGTATTCAGGTTGTGTTGCTTTCTGCCACAATGCCAACTGATGTGTTGGAAGTGACCAAAAAATTCATGAGAGATCCAATTCGAATTCTGGTGAAAAAGGAAGAATTGACCCTTGAAGGAATCAAACAGTTTTATATTAATGTTGAGAGAGAGGAATGGAAGTTGGATACACTTTGTGACTTGTACGAGACACTGACCATTACGCAAGCTGTTATTTTTCTCAATACAAGGCGCAAGGTGGACTGGCTGACTGAGAAAATGCATGCCAGAGACTTCACAGTTTCTGCTCTGCATGGTGACATGGACCAGAAGGAGAGAGATGTTATCATGAGGGAATTCCGGTCAGGGTCAAGTCGTGTTCTGATCACTACTGACTTGTTGGCTCGCGGGATTGATGTGCAACAAGTGTCTTTGGTTATAAATTATGATCTACCTACCAATCGTGAAAACTATATTCACAGAATTGGCAGAGGGGTCGATTTGGGAGGAAAGGTGTGGCTATAAACTTTGTTACTGAAGAAGACAAGAGGATTCTTCGTGACATTGAGACTTTCTACAATACTACAGTGGAGGAGATGCCCATGAATGTGGCTGACCTTATTTAATTCCTGGGATGAGAGTTTTGGATGCAGTGCTCGCTGTTGCTGAATAGGCGATCACAACGTGCATTGTGCTTCTTTCTTTGGGAATATTTGAATCTTGTCTCAATGCTCATAACGGATCAGAAATACAGATTTTGATAGCAAAGCGACATTAGTCGTGAGCTCTTGTGAGGAAAGTCATTGGCTTTATCCTCTTTAGAGTTAGACTGTTGGGGTGGGTATAAAAGATGGGGTCTGTAAAATCTTTCTTTCTTAGAAATTTATTTCCTAGTTCTGTAGAAATGGTTGTATTAGATGTTCTCTATCATTTAATAATATACTTGTGGACTAAAAGATATAAGTGCTGTATAAAATCAGCCAATTATGTTAAAACTAGCATATCTGCCTTTATTGTGTTTGTCATTAGCCTGAGTAGAAAGGCCTTTAAAATTTTTTTAGAAAGCATTTGAATGCATTTTGTTTGGTATTGTATTTATTCAATAAAGTATTTAATTAGTGCTAAGTGTGAACTGGACCCTGTTGCTAAGCCCCAGCAAGCAATCATCCTAGGTAGGGTTTAATCCCCAGTAAAATTGCCATATTGCACATGTCTTAATGAAGTTTGAATGTTAAATAAATTGTATATTCACCT 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@rCer/1803/3806_66_CCS TGAGTGTATGGAAGCTGTCTATCTGTCCTGCAGTGTATCAACTGACTCTGCTATCCCACCCAAAGTTCAGCCTGAGGTATATTTCGAGTCGAGGAGGTGGCTGTGCTTTCAGAGTAGAGAAGCAGTTATGAGCAGAATGGTAGAGGAAATCTAGAAAGAACCGTCTTGATCAGATTATCTCCATGGTGTGAAGGGGAGGGGCATAGGAACCAGTGGCACTTTCGTTTCGCATTTCTGTCCTGTGGTGACACTTCTGCCATTCCAGAGGGTCGTTGAATACTGGCAGGCTGGGAATTCAGTTATCGTCACGCTTTGTGGATGGGACTTCATCTCGGAGTATGTTTTGGACAGCTGAACTATTTTCACATTCGGGATTTCTTTGCTAGGTAAGTCTGGCAGCTTGTTTTGTTGATGTATGGTTGGCATCTTTACCTTACTCGCACTTTGGACATCCTTCTTTGTGTTTGATTTATCTTCCACAATGCACCTGGTCATGATACGAAAGTTTCTTACAGTTATCTACTGTATTGGAGTTTATTTTTGCTTTTGATTTGCATGTCGTGTTGCACACTTGTTATATGGTAAGCCATCTGTGTTCAGTCTGTGTCATCAATCACAGGTTGGAAACATTTTCCTGATTTTTTCACGTCTCTAGTTTTTTGCCCTCCAGTTCAAGTTAGCTGGCTTCTTTTTGTGGCTGGTTTGGGGGAGGGGGGTTTGGGGTAGGTGGGATGGTTGGGGGCACTGCGTTCCGCGCCCATTCTGAGTTCAGGAGGGTTTCTTGTGAAGTCTTTATGTCATCATTACGTGCTTTCAGGCATTGTGTGATCTGCTCTCCCTCCATGATTAATTGCGTGCAAACAGTCTGAGCGGTGGGCATAGGGGACTATCTGAGCCTGACCTGGTAGGACTGGGGAGGAGGGGCGCGCCTTGGCGGAGGGGGAGGGGACCTGATCCAGCAAGAGGGTCCGATGGCTGTACTCAGATTTTTTGCATGGCCCCGTTTTGCTCACGCCGTTCGGTGGTTATTGGAATCCTTAATGTATGCCTGCAGCTCTGTTCCATGATACTATATAGCTTTGACCCAGTCTAACATGCTTTTATTCCACTCTTTTGTCTCTTTGGGGAACTTCGCGTTTGTTACTAAAACATGGCAGCATCCATTTCATTTCTTTTTCAATAAGGCAGGGCTTGGGAGACCATGCCACCATGCTCCAGGGCCTGGTACTCTCAGCTGGACAGCTGAATGGTTGATTAAACAACTTTGTGCCTTCGCGCTTTTTCTCTCCGAAAGGGTTTCACTTCTTTGATCTGCTCTGACGAGTGTTATGGTGTGCCAACAATTCGGAAGCTTTTATCTGGCTGGCTTGTTGCTGTAGAGCTTTAACTCAACAGATGTCGCTCCAACTTCAAACCTGTGTTGGATCCATCTCCGCTAGTTCTAGCTCGTCTTCCCCAATCTCTTATGATCTTCAAGTACTACTGCCACAGGACGCAGCTAAGCAGGGTCATCAACGCAGGTACTTGGGGATTGTGGGCGGTCTTGCGGAAGCGTGGAGAGCGGCTGATCGTAGTCGGGCAGGGTGTCTGGTTGACACGCAAACAGCTTATTTTAGGGTAAAGCATTGGAGAGTGGCGCTGGGGCCGCCTGGAGGCCAGTGTCCCGTTACCTCTGACCATCGCATCTCCGGTGTGGTATATTTGAGTGAGACGGTCCTTCAATAGACGGGCTAGCCCTGTAGGCAGGATCTTGTGACTCACCTGACTTTTGCTGGTCCCTTCCTTGTGGGCAGAGTTGAAGATCAGGTAAAGAGGATTGGGGAGGGGACGTTGCAGAAACATGCGGGTGGTCCCACCCAGGTTTTTGAGTTGGCGCGTAGCTCTGTTAGGTTACAGTTCTCAGTGTCAACAGCGCAATATAGCTTTCTGATTTGTTGGCCCACATCTCGTAGCAGATCACAAGATAGTGATAAACTTTTTTCGATCCGAGATAGAACCGAGGGGCAAGCAAGTTGTTTATCACCTTCGCTGTCAGCCAAGAAAGTATCCAGGCCTGGGCTGGGTTGGGCTATGGCTCCCAGCCTGGCTCCTTTTGTGAAGGAATATAGAATGATGCTGACCATGTTTTATACAAACCGAGTCCTCAGGTTACAAAGATGTGTGATAGAAGATGTGACTGGTGTCAAATGCTTATTATGTTTTATTGGACAGGCTGCAGGTCTTACTTAAGGGTTCATACCACCGGCTGGCCTGGGAGCAAACGGGGCCTGTGTCAAAGAACTGAGTGGATGCCATCTGGACCTCTGTGGATCAGGTCCTTCGCTCCCCCTCCGCCAGGCCCCCCTCCTCCCCAGTCTCTACCAGGTTCAGGCTCAGATTGAGGTCCGCTTCCGCTCAGCATCTTGTTTTGCTCGCAATTGATAGGGGAGAGCATCAACCATGCTCTGAAGCACGTATTGATGCATGAAAGACTCACAAAACCCCTGCTCCTGAAGGCTCAGAGCTGGGTTTCCAGTTACGCAAAGTGGCCCAAGCCTATTCTCTGCACTAACCCAAACCAGCCGTCCCCAACCATGCACAAGATAGGAGCAGCTGTACTTTGAACTGGAGGCAAGAATGGAGAGTGGAACATCAGGATACATGTTCCAACCTTTGTTGTGATTGTTATGACACAGAGTTGACAGGTGGTTACATTACAGTCTGTGTCAACACGACATTGCAATCAAGGGCAATATTAATCCATTTACAGTGATACTGTTAGAAACTTGGTTTGGTATTCGATGACGTTGTGGGGCATTGTGGAGATAATCAACAGTAGGGATGGTCAAAGTTCAGTGTAATATGGTGTAAGATGTGCCACCTTAGTCCATCAACAAACGATTGGCTGCCTGCTTACCTGAGCAAGAATTCCCTGGTATTGTGAAATATGTCAGCTGCATCTTCGAGATGAATGTACCTCTATTCCTACAGCAGGCTGGTGACTTTAATGATTTCCCAGTTTCTTGAGCAGTTCAGACTTGGAATGGGTAGGAGTTGTCACAAATGTTGCGAAATTGTGGATAGCGATTGCATGGGTTCTTTTTGCCTTTCCTTATCACATGGGTATTCTGTATCAAGCGGGTTCTTTTTAGATTTCCTTACTCTTTCTGTCTTAAAACTTGCTTCTCTGCCTGGAATGCACAGTACTTGCTTCTGATACCTCAGCGCTGCATTTGGGTGGGTAGTCAGGTCAGTTGATCTTTGCAGGAGGTGCAGGCTTTTCCATATTCAGTCTCAACCACGCCGCAGTCCTTTCTTAAGGAACTGTGCTGGACTGATGATTGCTTTTGCTTGGCTTTTGGGGGTTTTTCTCAACAAACTTAACGGTCCTGGAAAACAGTCCAGGAATTAACGTATCGAATTGTTTCACTGGTATATCTTTTTCTACTGTGAGCATGAACGTATGCAGAGCTGGTTTGTGTTTTTCTCAGAGGTTCTTCTAACCTAACTAATTTTTTTCACTGTTGACAAGGATGGCTAAGGTTGCATCTGTGACGTACGGCTGGGCTTGGCCATCTAGATTCATGGCGAATGGTTTCCCATAGCATTCCTTTTATTTCTCTGTTCTATCCTTGGGTCTGCCTAATCCATGACGATAGTGGAGTTCCTGGGGTACTAGCTGTTATTCAGGGCAGTTAATGATGTCTTGAACCCTTTCTTTTCTCTGATCCCATCTGACTAGCACTTCCTATAGAGATGAC 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@rCer/1805/1783_63_CCS ATGGGGGGCCGGGCCTGCGTTCTCTCCTCCTTCCTCCCCGCCTCCGGCTGCCGGCAGGACCTTTCTCTAGCTGCCGCTGGGACCCCGTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGATGGAATTAAACCACCCCAATCATTGGAAGATTTGGAACCTCACTGAAAATTGGTATTGTTGGATTGCCAATGTTGGGAAATCTACTTTCTTCAATGTATTAACCAATAGTCAGGCTTCAGCAGAAAACTTCCCATTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGATGAAAGGTTTGACTTTCTTTGCCAATACCACAAACCAGCAAGCAAAATTCCTGCCTTTCTAAATGTAGTGGATATTGCTGGCCTTGTGAAAGGAGCTCACAATGGGCAGGGCCTGGGAAATGCTTTTTTATCTCATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGTGCTTTTGAAGATGATGATATCACACATGTTGAAGGAAGTGTAGATCCTATTCGAGATATAGAAATAATACATGAAGAGCTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAAGGTGGCTGTGAGAGGAGGAGATAAAAAACTAAAACCTGAATATGATATAATGTGCAAAGTAAAATTCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGATTGGAATGACAAAGAGATTGAAGTGTTGAATAAACACTTATTTTTTGACTTCAAAACCAATGGTCTACTTGGTTATCTTTCTGAAAAAGACTATACATTAGAAGAAAAACAAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCCTTGGTCAATTCCTTTTAGTGGGGCCTTGGAACTCAAAGTTGCAAGATATTGAGTGCTGAGGAGAGACAAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATCATTAAGGGCTGGGTTTGCAGCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACTAAGGCTCCTCAGGCTGCAGGAAAGATTCACACAGATTTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAGGAAGGTTCTTGAAAATGCAGTCAAGGCTGCTGGAAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAACACACCTCAACAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAAACATACAACTTCCAAAGGCCATCTGAGTTTTTTTTTAAAATTAAAGTTTCTGAAAAACCATGGGACAAATAAAGTTGGGGAGATGGGAATCTTCAACAAATAAATTATTTTTATTTTGTTTTAAATTTAAAATACTGTGTGCCCCCCCCCAATGAAATGCAAGTTCACAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTT 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@rCer/1807/4709_86_CCS CCTGGCTACGATGGCGCCTCGGGTCCCCGCACCCACCTCCTTGCTGGCCTTCCCGTCGCCGCTACCGAAGCGTTTTCCAGATGTTCCTGCGTTAGTATTTGGGAAAGTAAGCTAGAAGCGCCACGCGAGCAGGTCAAAGAATGATGATGTTTCGTATTTTGATGGCAATATTGGAGCTCCTTCTTTACTACTAGACTGTGTTGGCGAACTTCTCCACTCTACATCTAGCAGCACAGTCAATGGATTCACTTATTCCACCACAGAAGTACCTGCTCCGATGATGCGGTGTACAGCAGATATGCTCACGAACCAACAGTGGACACGATAAACATTAACATACTAGGCAGCTTCTGAGTGGCTCATGCCTAGCATAGCTAGAGCAGTTTCTTACTTAAGGCATGGTCGCTGCATGTCAATGCCAAGGACAGTTGTTAAAGAGATCAAGCTCTCCGATTGTTGCCATCGAACACAATCATCTAAGAGGTGTAGTGGAACTTTTAATCCAATATATGGTGCTGATACTGTACACACCGCAAAGTAAATTTTGTTTAAACACTGCATTTGATATTTCATATAGGACAATGGAATTGAAGATTTTAGCAGAGATATTACAGATTGCTATATGACAGAACAAATCAACACAAACCCACAGCATGAGTCCTGACACTGTGACAATACATGCATGCCAATCACCACTAGTATTGATTGTTGAATACAGTAAAAGTGAGATACAAGCTGGAGATAGGGGTATTCCGCATAGGCGGTTGACATGGCTAAGCAGGAGGCCGGACTGGAGGCAAGGACGACGTAGCGTGTTGCTGGTGGCGTCGCATAGTGCGCCATGGGCTTGTCTTCGCGCGAGTGTGGTGGGGGGTATGTAGTTGCCGAGGTCTTCGTACGTTTGTTAGATGCTGTGTCGGGGTGGAGTATTTGTACTCTTTATCCATGTACTGCCTTACTAGCCTGGAAAGTAGCGTGCCGGCGTCAGAGTGGGTTGAGCCGTCACTCGAAGATGTTGTCTTCCTTTGCGAGTGATGCCACGACTTCCGCGTCTCTTGGCAACAGTCAGTTATTGTCGGACAACGGATGGGATACGTGTATAGTAGTGGACAGTGGGCACGAATCTCCTTGTGCCTAGATAAAGGGATGGAGATCGGGGGGCTCGGTTTTCACGTCGCACACGAGTTACAATGGGGTAAAAGTCCTTTGTAGCTGGTTCCAGCGCGAGGGCGGGCGACTCTCAGTGAGTTACTGTTCCTGTGGTCCTTGTGCTGTCATGACCAGTCGAGATTTTCCCTGGGGTGTGGGACAATATAGCATAATAACATGGAATGCGCACTCTTCAGTGGACCGCAGAGATATGTTAGCTTTGCTCCACGGAGAGAGGACGCTTACCGATGACATGGGTGAAGTTCCTGTCAGGTTGGGAGGGCGAGGGCTGCGATACATTCGTGCTGTGGTGGACTGCGACAAAGGAGGGGGAGAAATCGTGTTTGAAGGTTTTTTTGTGCATGTTCTATTGCATGCTATTATGACACGGCACTTGTGGTGGTTAGGAGATTAGTCGGTGTTCGGTGGGCACAGGTTTAATAGCTCCATCACAGCACAGCATCACCTCTAGTCATAACTGGCCATTGGCTGTGTGAGGCGAGCCCTGCAATCTTGCCCCACGCGAATGGGGAGCTCTCACAGATGACGAATGCTCGCAGGCTAGGGTACTGCGATCGGCTTGTTTAGCTTCACCATATAGGCTTCTAAGCTAATTTTACCCAAGGAGAGACTATAACTTGGCTGGGTGATTTGAACAGCGTACTAATAATTCGTTTTGGGCTGGTGTCTGACACATTACTACTGGGATGTTCTGGAAGGAACCACCAGCTTAATTGTGGGGCGACAATGATAAGAGAATCCAGCTCCTCAAACCTCAGGGTATCTCGCTGAAGGTAGTCTGAAGTGTGCCAGGTTAACACTAGACAAGACCCGAGATCTCTCTTTGGACTGGGAACCGAGTAACAGAGTGTTTAGAATGGGATATTGCACAGGCATGTGTATTATAAACAATGAGACAGACAAGACTGAGAGAGAGGCCAATCTGGAGGTTTCGCAGCACAGGAAAACAAGAAGGAGCAGGGGCTCTGGCGATGAATGACACACAGTGTTGCGATGCATGGGATGATGGCAGACGCAGCTATTCTCATGGGAGGACAATGGTTGGCCGACTCAGCATCGCCTGGAGACGCAGCGCTTCCTAAAGACGAGCGGCATCTAACACAGCAAGGATAGCATCAGCTGACCAGGCGGCAATGACGACCATCAACAATGCCACTGAGGAATATTGAGCTTGTAGAAGAAATCCTCTGCGGCAGCAGGCAAAATCGGCACTTCGTGGTGCCGACTACTGGTGATGTGCCACGTGTTGATTGCAATGGAAAAGAGTCTAGTTAATCTACGCCTGTGAGAAATAAGGCCAACCGAACGGGAACATTGGTCTAGGGTGAAATCTCTCCGTCTTTTACTTTTGAAGGTCAAGAAGAATACAGTCTTGAACTGTTACATCAACAAAGAGCTTACGCCCAAATGCGCGGATATACAGAATGACAGGAAGGGACCTACCAGTTCATTGAATAATTGGACTTAAAGCCATTTGCAGCTTCTGGGAATTTACCCTATCGAAGTTCTTGCACGTAGGCCGATCCATTAGGGGGTACGGTGGCTCGGCTTATGAGTATCACCAGACCCATTCATGCACGGTAGCCCAATGATGCAAGTTTACTGAGAGCCTTTCCTTTCGGGATCGGCCTCGGCTCTTACCTGCTTGGCAGGACATGTTCCTTCAGGCTTCCCGGGTTCATGCTGCGGCGTGCTGGGGAGAGCTGCACTTGGCCAGCGGCCGGTGACTTCCTGTGGCGGAGGTGAAGATGCTGGAGAGCAGACGAGCGCGACTACGCTGACAGGCTAGTATCACGCTCATGGAGCCGCATGGGATTCCGGCACCGAGCCGCATCCCTGTTGCTCATCATACAATCTGCCCAGCGCAATACGTTTGTGCTGGGCGGGCGCGGTCAGCCACAACATCGGCTTCGTCCTGGTGCACGGCTAGACTACATGATTTGGATGCAGAGCTGGTGCTCCCACATCGCAGTTGCAGTGGGGAAGCAGCCTGAACCTGGACTCGCCAGTGGCGTAGGCGCTGCCAGGTTCCTGAGCCACATGGATGTGTTCAAGAGAGTTCATCACATTTGCTCGACTCCATTGCTGGTGGATGACGTTAAATGGGGTGTCTTGTCTCGCCGCGTGCGTGCCACAGGCAAGCCTCTCACGCTGCGGAGTGGGAAGTGCCGCTTCTGATACATCCGGCCGGCAAGCCGCTGCACTGACTCATGCACTGCGATTGAGACGTTATGCACACCTGATCCCCCAGACAACTGGCACCGATCAGCCGCTCTACAAGTGGCTCCGCCTGCCTCTCGGATGACTCGAAGCTGGTTCCTGTTGGTACTTCAGGCTCTCGGGGCAGAAGCTACCACTGTGTCCCATATGCTACAACCACTGCTAACACTCCTTTCCAGAAGACATAGAAACGCATCTCTACTATAGAGAAAGTGGTTGGACATTGGTGATTGTGATAGAATAGACCGCCCTGTACATTCCAGACTTGCTGAAATGTTTCTATTTAAATGGGTTGTTTTGTTTGGTTTTCATATCGCGGGGGCTGTGTCTCCGAAATGAAGTTTTGGACTAAACGATTGTCTGGAAGAGAGTCGCACGCTCGAGAAGACCACAATTATAGGCCTACTGGTTGTCTTTTGGTGGAAAGTCTCTTTTCCTTCTGAGGGTTGTTCAGGCATAGCTAAGCGGCTAAATAGGTATGCGTCTCTGCTCGTCAGAACCAAAACAGTAAGACAACGCGTATTTTAAGGGGTAGGTGCGCGCATGTCTCGTTGTGAACTGCCCCAGCCCGTGTCGAGGGCGGATGATCATTGTGTGGATCGTCTGCACTTAAGATTGTCTGTATCGGGAGGGGATGGGGTCTGGGACGGCCGGTTGGATTACGTCCTATAAGCGTGGCCGCCTTTTTGGCTTGACAGACTCGGATCTACTATATCTCACGAGACCAAGAGAGCCGGAAGGTACCTATTCTCGGCCAGGAACGATCGCCGTCTGCAAATGGGCCTTTGTGTCATTCTGTTGGAATAACACGCTGTCTTTCAGGAGATTTGGTTGGGTTTTCAGCTGTCTCTAGTTGCTAACCTTGCACACCCTTTTTGTCAACTAGGCACCGAGAGGGGCCCAGGGAAGAAAATGGCATTTATATGTTCTGTTTCATATTCCAGCTCGGGCGGGGACATAGAGCCGCCCACAGTGGAAGAGTGGCCCACCACCAGTATCTTGCGATGGTACCTCATGAAGAGAATAAATACATTGTCCTCAGATGTCAAGCACTTTTGCTTCTGTGTGTACCTACTTCGTGACTGTATGGCGCCCATATGTCTCTCTCTCTATCCCACAGGCTGAACACCTATGCATATCAGTGCTATGCGTCTCTTTATGGCAATATCCTAAAAGTTAATCTCTTAATGGTCTCGCACACTAGAATATGATGAATACAGTTGATCTTCTCAG 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@rCer/1809/25_2493_CCS ATGGGTCCTCCCGCCTTTAGTCTCCCAAGTAGCTGGGACTGCAGGCGCGTGCCATCACGACTGGCTGATTTTTTTTTTTTTTTTTTAGAAAAGACAGGGTATTGCCGTGTGGTTCAGGCTGGTCTCGAACTCCTGGTACTTGAGCAATCCTGCCGTGTCCGCCTCCCAGAGTGCTGCGATTACAGGTGTGAGCTACCACAACCGGAGGAAATTTGATATTTTAAATTGTGAATAGGATGGGCCAGGTGTGGTGGTTTACGCCTATAATCCCAGCACTTTGGGAGACCAAGGTGGGTGGATTGCTTGAGTCCTGGAGTTTGAGGGCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAACATTAAAAAAAAAAAAAAAAAAATTAGCCGCTCTGTGGTGGTGCACAACTGTAATCCCAGCTACTGGGGAGGCTGAGGCGGGAGAATCGCCGGAACTTGGGAGGCAGAGGTTGCAAATGAGCCATCATCATGCCACTGCACTGCATCCAGCCTGGACAACAGAGGGAGACACTCTCTCAAAACAAAAAAACCTAAAGTAAATAATTGGATGATGTAAAATACAGTCAAAACAATGTATTTTAGGCCAAAAGGAACTTAAAGGTCAAGATAAGTGAAGCTATTGTAAGAAATTACCCGGAGATGGCCAGTGCAGTGGCTCACACCTATAATCCTAAACACTTTGGGGAGGCCAGGGAGGGCATATCACTTGAGTCAAGGAATTCGAGACCAAACCTGAGCAATGGGGAGACCTCATCTCTACAAAAAAATAACAAAATCAGCCAGACATGGCGTTGCACAACTGTAGTCCCAGCTACTTAAGATGCTGAGGCAGGAGGATTGCTTGAGCTCAGGAGTTTGAGACTAACCTGGCAATATGCCGAAACTCCATCTCTTACAAAAAAATTTAGCCAGTGTTTGTAGTCCCAGCTACTGGAGTAGGGGGTGAGGTGGGAAGATCGCTTGAGCCCAGGAGGTCCAGGCTGCTGTTAGCTGTCATTGCAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAATTTGAGTTCTGTTCAGGCATTCTGCCCTCAAATGTTTTTACATGCTGAAGAAAAAATCTTGCATGTGAGATTTCTTAATCATCTTTGAGGTGGGAAGAGTGGAAAGAGGTAAATGTTCCAATTTTAAAGGGAAGGTAGCGTACTTGGTGTGCAGCAACTTTAATTGCATCAGTTATTGGAAGAGTTAGATTTGTAAAGACTTAGGAAAGGAAGGCTTGAGAAGCTGCATCAACATGGCATGTGTGGATTATAGGTTTGGAAGGACTTGAGTTGGAAAAATTGCTTTTACCACTTAATGGCTTGCAGTAAAGTTACTTGGCCTTTTGAGCATTAGTTTCCTCAGTTTAATTAGCTCCTCTTGTGACATTAGGGTGAGAATTAAATGAGAATTTAGACAAAGTAACTAGTATATTTCAAATATCTGAAGTAACTGCTGTTATAATTACTACTAAAAGTCACTGTGGATTTACACACAAAAAGAATATCTTATAGATCAGTAGTCTTCATAATGTTTGCTTTTGGAGGTAACTTAAACATTTGATTCAAATTTTATGTAGTTGTTTATTTGAGACAGGTTCCCCCTCTGTCACCCAGGCCAGATGCAGTGTGGTGATCTCGGCTCACACGGCAACCTCCAGCCTCCCGGGCTCAAGCTATTCTCCCACCTCAGCCCCTGGAAGGCTGGGACTTCACAGGTGCGTGCCACCACACCCAGCTAATTTATTTGTATTTATTTTTGTGGAGATGAAGTTTCTTCATGATACCTAGGCTGATCTCTGATCTCGAATTTATGGGCTGAAGCAATCCGCCCACCTCGGCCTCCCACAGTGCTGGGATTACAGGTATGGGCTGTGGACCACCACACCTGGCTCAAATTTTAGTATATGTGCTACTGAAGTGAGCACGCCTGGTTCAAATTTTAAGTATAATTTTGGGCCAGGCGTGGTGGTTTCCCGCCTGTAATCTCAGCATGGTGGGAGGATTGCATAAGCCCAGGAGTTGGAGACCAGCCTGGGTAACCTGTCTCTACAAAAAAAAAAAAAAAAAAAAAATTAGCTGGCATGGTGGTGTCCACCTGTAGTCCTAGGTACTCTGGAGGCTACAGTGAGCCACAACAGTCCAGCCTGGGTGACAGTAAAAGCCTGTCTTTTAAAAAATAAATAGGCTGGGCATGGTGGCTTATGCTTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTCAGGTCTGGAGTTTGAAACCAGCCTGGCCAACATGAGGAACCCTGTCTCTACTAAAAATACAAAAAAGTTAGCCGGGCATGATGGCGGGCGCCAGTAATCTCAGCTACTGGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACTCCATC 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'-*-+-*++*,--+.'--,-,,-+.-',))**++&,,+(&*,(+*),-,-,)-++--+-,+)(**+,,$,+,,+,,,,,++*()))*,*-.-,---)*+'',.,&,,,,''&'-,--,*()-(*),,(,+-)*(-.-,+$+(#*-*-(&,(,,,,,*-,,,(-,(+--,*---++-),-,.--*,-)+,)+--(&*,(,+-,.,,*',(-+*--)),((-+,,,,&*'+--.--,,+,&)),.--.-,)+,*%'%),&(,(,*--+-,&)%#+--,*--()')(*-.*.+.-*-**-.+-,-,(,()-+,*-,.*,(-,))*'-+),,.,,(')*.-),%-%(+--&&''(+,'($*-,%++,-,-#,,+,,+)**++,,,,,+*++--+.,$,)*-,)+,')*-,,*),,&++-.+%+,-,%(*,''++--(--+,(*,(+-.---,-,-')(-(+-,.)--++-(),,*+)-+)%),-+(,--)*-)++),-(---+-++*$*,&&*,&(&,--.-,&+,-+-,.-*,(,-***,+--)---,$*++++*)-*'*+)+%+(&)-*-(++)+-+()$*+,++,--,(+-*-(',$+-+)+-,++.,.%,,,',)-,)-()-)+,),.-,(+.+(*(+&*--),++)-+-.-(--,-((++---(.,,-,-++',,%*)))(*+)++,+*,--.,%)(++&(-+#'*$$*-+.--*.,'**&,-,,&,,-.,)--+'++)')(+,++&#*-%++(**+++-*-*'-,))))),-,(*&,,-,($-,---+(%,'(,,,+--+(,*,),,)+,-,(,+*(*-.-+-,++-+..--,--,*.,.(+(&,,,-)-,))),(,+),),()*--+--*(),,(,,+((*-,'-)*,$)+*-'+--,.+(,+*,'--,-,,&**'&-,--**+-.++,.-,))&,,+**()&,,*+,(+--+,---+-..,.-)+(,('*--.-*+--,-.-+,+.-()+*--))*--.,,,-)+$)'+,-+)+-)*,'%(+()*(+,+,.,-,(+,$**+,,+**))***,,+'((-,,-),',-),+-,.,,(,()-'+)+((,++,&(+,&'(()+,+*#&%$++++)''*.-,-,+--+*,',)*,.),(,+--)-+((()%%+(%)(*+,*.,-.,-+*-*.-)(&,+,$+$),+%,+$*,-.*,)*)+#,,),.-.--)+-+*&'-*%-(&,,,-,(,--,()%$*',',,,-)-,-*,.-(&&**,,($+,)+(..+.-.-.-)--+)(,,()-,+,,+.-&#*-+&)+++,+.++)()-+.+.,&+(-&,*+)-*,+',+,#+))*+-,'%,+,*+.+,&,)---.-)+++,,+*..,),,+'-(,),$,**)$++#$,(*()-(*(*-+%+*(,(++%++,*-,-.--+)+-+,+(+++,),-.--)++),,-+.*--+))-+,,-,%,,-)-,--+&++,+-*,--,(+',&(+.,+,(,-)-($')+-)--),,%--,(),+-+(+,.,+..,+---+(,,,,)),+--,))$'+*-,))(-,(',-.*&+-.--'-,+%'+--+-*(+)$+*(+*,.+*$++*-,.-'-++,,,,---,)*,+),,,*,.,''+''')'((+%(*)''')')&,+)'(((+-)#((+-,(,-.,-,,**+)-+(+*,--*.,(,,.-+,-+&-*(+)'+*,'+(,'(**-.,-,,,-),(*)+(,-,)*-**#,*-)++-,&)%()'(-(*/1-.,0++0/10..1(-%/,+$/-*(+-.0)(,,+$.00/.,').01*/*0.-00/-/0%,..10-/'/-..+/0011/&.011,00*0(..,,)-1.&)-/,,/01*/+&'-.),)(,1/0/+0201/1/*/0'..-.0(1.-1.1*'+0111-000100121/..,%*0010-//,/+0-,,,*0&.11/11.000211110,.0102.',,01.00-220+0$-1)*1'.,-,2,-1100,.,*1'*,#(*-01-'./1*,//011-0/,0,.0///$-00.2111/12,*.20,.+-02-/,.*/2,1.0,-,0,+0'0/1--*+,,+#,+///034320121220.14526/46/%2.*1/652624+0254520+11.04+015(0236655516-/4655445136.1*3034446.415113655..055-6611366504/556$110/+)(2234130-(3320-,-426426.544+545/250624+425363431305.2/-)21/+54152&,12/6634/1-0,2.0-.62-301/*,)-145/2+31'2,()3.2,4414/1../-53(1233,2+)352102$2-430041641213555146511631336.130436/221)462-+31466/3523321-3163*064-3-450644(1/262464621055413/4545.44/261665/ @rCer/1812/25_2071_CCS ATGGGGAGCCACAGCCGGGCCTGGCGGGGGGACCATGGGCGCCTGGGCCTCTAGGGGCCGGGCCGCCCGGGTCCCCGCGCCGGAGCCGGAGTCGGAACCCGAAGAGGCGCTGGACCTGAGCCAACTGCCCCCGGAGCTGCTGCTGGTGGTGCTGAGCCACGTCCCCCGCGCACGCTTCTCGGGCGCTGCCGCCAAGTGTGCCGGGGCTGGCGAGCCCTGGTGGACGGCCAGGCCCTGTGGCTGCTGATCCTGGCCCGCGATCACAGCGCCACCGGCCGCGCGCTACTGCACCTCGCCCGCAGCTGCCAGTCTCCCGCTCGTAACGCCAGGCCTTGCCCCCTTGGCCGCTTCTGCGCGCGCAGACCCATCGGACGCAACCTTATTCGCAACCCCTGCGGCCAAGAAGGCCTCCGAAAGTGGATGGTGCAGCACGGTGGGGACGGCTGGGTGGTGGAGGAAAACAGGACAACCGTGCCTGGGGCCCCTTCTCAGACGTGCTTCGTGACCTCATTCAGCTGGTGTCGCAAGAAGCAGGTCTTGGACCTAGAGGAGGAGGGTCTGTGGCCAGAACTGCTGGATAGTGGCAGGATTGAGATTTGTGTCTCTGACTGGTGGGGAGCCCGACACGACAGTGGCTGTATGTATAGACTACTTGTCCAACTTCTAGACGCCAACCAGACTGTTCTAGATAAATTCTCTGCTGTGCCTGATCCCATCCCACAGTGGAACAACAATGCCTGCCTTCACAGTTTTGTTCTGTTGCCCAAGCTGGAGTGCAATGGTGCGATGTCAGCACACTGCGAACTCCGTCTTCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGACTCCGGCTGCTAGAGATGGGCGCCCGGCTCTCGCGGCGACGGCTGCCGGCGGACCCGTCCCTGGCCCTGGACGCGCTGCCCCCGGAGCTGCTGGTGCAGGTTCTGAGCCACGTGCCTCCACGCGCCTTGGTCACGCGATGCCGTCCAGTGTGCCGCGCCTGGCGCGACATAGTGGACGGGCCCACCGTGTGGCTGCTGCAGCTGGCCCGCGACCGCAGCGCTGAGGGCCGCGCACTCTATGCAGTGGCCCAACGCTGCCTGCCCAGCAACGAAGACAAGGAGGAGTTTCCGCTGTGTGCCCTGGCGCGCTACTGTCTGCGCGCGCCCTTCCGCCGCAACCTCATCTTCAACTCCTGCGGAGAGCAGGGCTTCAGAGGCTGGGAGGTGGAGCACGGCGGGAACGGCTGGGCCATAGAAAAGAACCTAACACCGGTACCCGGAGCGCCTTCACAGACCTGCTTCGTGACCTCTTTCGAATGGTGCTCCAAGAGGCAGCTTGTGGACCTGGTGATGGAAGGTGTGTGGCAGGAGCTACTGGACAGCGCCCAGATTGAGATCTGTGTGGCTGACTGGTGGGGTGCTCGAGAGAACTGCGGCTGCGTCTACCAGCTCCGGGTCCGCCTTCTGGACGTGTATGAAAAGGAAGTGGTCAAGTTCTCAGCCTCACCTGACCCGGTCCTTCAGTGGACTGAGAGGGGCTGCCGACAGGTCTCCCACGTCTTCACCAACTTTGGCAAGGGCATCCGCTACGTATCTTTTGAGCAGTATGGGAGAGACGTGAGTTCCTGGGTGGGGCACTACGGTGCCCTTGTGACCCACTCCAGCGTGAGGGTCAGGATCCGTCTGTCCTAGCGACTGGACTACCACCTGACGTCGTCAGTCAAGACCAGCCTTGAAGCCGGGTGCGGTGGCTCATACCTGTGGAATCCCAGCACTTCAAGAGGCCAAGGTGGGAGGATCACTGGAGCTCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGGCCCTGTCTCCACAAATAATTTTTACAAAATTCGCCAAGCATGGTGGTGCCGCCTGTAGTCCCAGCTACTCGGGAGGCTTGGGTGGGAGGATTGCCTGAGTCCAGGAGGTTGAGGCTGCAGTGAGCCGTGATTTCACCACTGCACTCCAGCCTGGGCGAAAAAGCAAGACCCTAT + II3KKKKJIKGKIKKK9KKEKBIKJCKKKKKGBKGD=KHKKGKKJKKKKKKKK>KKKGK9KKEKKIKKKKKF7KKKKKJKKKKKKKKKKJKJKKK>KHKKKIKKKIKKKKKJKKIKKJKKGKKKKKK?KKKKIKKKKKKKKKKKKKIFKBJKHCKJKKKKKK1KKJKKKKJKHEK>KJJJHKKJKJHKKKJKKKKKKKKKEKBJKKJKKKKKKKIKKKHKKJKIJKKHKGJIAKKKKKIKJ=JKKKKKHKKKKIKKJKKFH>DIABKIIKKJKJKKKIHKKKAJHKJGGIKKIKKBKKIKIJIKFKKEKHJJ8@JKJ(JKJHKKKJKKFKJK4KK?KKKKJKIKJKHKIKJKJIKKKKEAIKKEKKJJJKKKJJI?KKKJKI@KFKKFKBKKKJKKJKGF:KJHKKKJKKHKKKKKKKKKKKKKJGJJJKKKKKIFKKKJKKKKHAJJIKKKHKK>K4IKKJKKKJCKKKKKKFJKK8KKKAKKKKK>KKKKKKKIKKIKKKKKKFKKKJKKKKJKIKKFKHKKKKGKKKJKJKKKKKH@KKKKCKJJKGKKFKKAKKIKKKKKKIKJKDJKGJKKGKJKKJJHJKIKKKKKJKKKKKKJKKKJKKBK?KKKKIIKHKKKKKKKKJK@KKKKKKJKKKKKKIJKJ?KKFKKFKKIKKKIKKKKKKIKKKK;JKK?KKKK7HGKKGKKJKIKKKJHKKIKJKKDKJKKHKKKKKIKEKKKIKKKKKDKKKKKIKJA6JKKKJKKKKKKKK?HJKKKKKKKKKK8KIKJKKKKKKKKKKKKKKIKIKJKKGKKKKKKKK2HKKGKKKJKKHJKKKHAKK?KKKKGJKJKDKJHKKJKKKCKKKHKKKKHKKKIJKKKKKJKKGK9KKKJCKCKHKAKKGGJJKDKK5KKKKKIKKKKKHKKIJKIKIKKKKJKKDK.IKK8KKKKH9KIKDKJKBIKHKKKKKIDKKJKKKKKJKHJIJKJDKKKHKJF4IKKEKJJJKIIKK8KKAJ8EHGFJJIKIKJKKKKIKIGKKJKKBJKKKKKKKKKJKKKIKKIKKJKIK:KKGKKIJKKKKKKKKK=KKFKKKKKIGKK;KJKKKHKKKJJKGKJIKKKAIFIIG6KKAKGCKKIJKKJKJKIKJKJKK,KIFFHJIKCK8KKKKEFJGKKKKJKKKKKKJKKJKKKKKKKKKKKKIKKKKIKKJKJKKKKKKKKKJKKKKCJKKKKKKKKIKKHKKKKKKKKKKKKKKKKKKKKKKJKKKKKK:KKIKJKKJKKKKKKKKKKKKKBIJKKKKKKKKJKKKJKKKKKJKK7KGKJKKKKKKKKKKKK;KKKKKKKKKKKHKKKK7KKKKKKKKKKKKKKKD;IJGKKIK?KKKKJKKKIKKKKK;KKKKIJKKJKKKKKKKKEKFKKKIKJKKKCK>KK3KKGKJKK;KKEGKIKIDKIKKKKKJKKKKKKKKKKKKKKKKKKKK9KKJKKKKJKKKKKKFKIKKKHKKIKKKDKKIKFKKKKKKJ7IJFKKK:KKKKKKKKKKKKKKKKKIKKKKHHJKKJKJKKKKKIJKKKKIKKKHKDKKKKKK4KKKJKJKGK6KKK8JHKKJKFJDKKIKKKJKKKJKKIKKKKKCJ@KKJKKHKKGKKJGKKKHKKKKJKKKKKKKKKKKKKKKHKKKKKHJKKKKKJKKKKKKKF>KKKJJKKKKKKKHKKKJKKKKKKKKK:KKKKKKKKKKKKKH:J @rCer/1814/25_2097_CCS ATGGGGAGAGAGAAAAGACTGCGAGGTGGCCGCAGCTGTGGCCGGAGAGGTGGGAGTCGGAGCGAGGCCCTCTCGGGGGAGCAGGGTGAACGCCGGCCACTCCAGGATCCTCACTCGGGGAGAGGAGGCATACCTCGCGGTGTCACCTCCAGCCGCAACGTACTCCGGGTCGGCCTTGCGCTCGGGGCCTGAGAGGGGCGGCGGCGGGGTCAGGGGCCGCATAAAGAATGAACCAGCAGTGGAAGAGAAAATACTGCAAGCTGGCTGACTGCTGATGAAGAAAATGCTTTATTTTTATGGCAGGCATCTGTGGGATCTGTAATAGTAATGATGGCTGGCTGTGGTGAAATTGATCATTCAATAAACATGCTTCCTACAAACAGGAAAGCAAACGAGTCCTGTTCTAATACTGCACCTTCTTTAACCGTCCCTGAATGTGCCATTTGTCTGCAAACATGTGTTCATCCAGTCAGTCTGCCCTGTAAGCACGTTTTCTGCTATCTATGTGTAAAAGGAGCTTCATGGCTTGGAAAGCGGTGTGCTCTTTGTCGACAAGAAATTCCCGAGGATTTCCTTGACAAGCCAACCTTGTTGTCACCAGAAGAACTCAAGGCAGCAAGTAGAGGAAATGGTGAATATGCATGGTATTATGAAGGAAGAAATGGGTGGTGGCAGTACGATGAGCGCACTAGTAGAGAGCTGGAAGATGCTTTTTCCAAAGGTAAAAAGAACACTGAAATGTTAATTGCTGGCTTTCTGTATGTCGCTGATCTTGAAAACATGGTTCAATATAGGAGAAATGAACATGGACGTCGCAGGAAGATTAAGCGAGATATAATAGATATACCAAAGAAGGGAGTAGCTGGACTTAGGCTAGACTGTGATGCTAATACCGTAAACCTAGCAAGAGAGAGCTCTGCTGATGGAGCGGACAGTGTATCAGCACAGAGTGGAGCTTCTGTTCAGCCCCTAGTGTCTTCTGTAAGGCCCCTAACGTCAGTAGATGGTCAGTTAACAAGCCCTGCAACACCATCCCCTGATGCAAGCACTTCTCTGGAAGACTCTTTTGCTCATTTACAACTCAGTGGAGACAGCATAGCTGAAAGGAGTCATAGGGGAGAAGGAGAAGAAGATCATGAATCACCATCTTCAGGCAGGGTACCAGCACCAGACACCTCCATTGAAGAAACTGAATCAGATGCCAGTAGTGATAGTGAGAATGTATCATCTGCAGTTGTTGCACAGCACTCCTTGACCCAACAGAGACTTTTGGTTTCTAATGCAAACCAGACAGTATCCGATCGATCAGATCAATCGGGAACTGATCGATCAGTAGCAGGGGGTGGAACAGTGAGTGTCAGTGTCAGATCTAGAAGGCCTGATGGACAGTGCACAGTAACTGAAGTTTAAATAAAAATGTCTTCAGCTCCATGCTCAAGGTTGAAAAGGTTACCTGTAAATTTCTGCCCACATAACATTATACTCATCCCTAGTAGTGCATTTTGGGAGTTGGGGTGGGAAGGGGTATGGGAAGGATAGACCCGTAATCAAAAATGTCTAACATGTCTCTGTTGAGAAATTTATTTAATGTAAGGAACTTGGGTGTTAATAGTTGAGAGCTGTTTAGTAATAACCCAGTTTTCTCGAGGTCTGTTTACTTTATAGTTTTTAAAAACTTCTGTAGTTCTTTTGGCCAGTGTGTTTGTATTATCTGTGCATTAATGGTCCTCATCTGACTCCTGCATTGTGTCTTATTTTTCTGCATGGATTGGCATAAGACCATTACTAAAATTTGGCACCTGTGAGATGTTTGATATTATGAGCAGGAAGCATAATTTAATGTAAGAATAGATGTGAATTTGGGATTTCAAAATAGATGAATAACTACTATTTTATAGTAAAGTTATTGATACGGAAATGAAAACAGCCAGTAACTTATGTTTCAGAATGTTTGTAACACACTTCATGGCGTTCCCATAGGCTTTGCTGTCTAGTCTTATAGTTTGAGGTTTTTCTGGTCAGCATTTTTCTTTTTGATTACAAAATTTATAATTTAATAAATACTAGAGTTT + KK>KKKKKKKKK@KKKKKKKKKKKKKCJKJKKKKKKKKKKKKKFKKKJHKK@KKKKKKKKKKKKJKKGKKKKKK'KKKKHJKKKKKKKDKKKKKKK=KKKJJKKKKKKKKKKJKKKGKKKKKKKKKKKKKKKKKKKKKHKJHKKKKKKKKKK>KHKFKKJKJKKKKJKKKKJKKKKKKKKKKKCKKKBKKKKKKKKKKKKKKKKKJKKKKKK>KKKKKKKFKGKKJKKKKCKKKKKKJJKDKKKKKK@KKKKKKKKKKKKKJKKKKKKKKKKJKKKKJKIDKKKKKKKKKK>KKKKIKKKKKIKIKKKKKKIKKKJKJKKKKKKKK:KKKKJKKKKKKKJKJKKKKGKKKKKKKKKKKKKKKFKKKK?AKKKKKKKKJKKKKIK:KKKKKKKKKKKKJKKK:KJKKKKKKIKKJJKJKKJKKKKJKKKJKKKKHKKKKKGKKKKKKKKKKKIKKKKKKKKIKKHJKKKKKKKKKKKKHKKKKKKKKKJKKKKKKKKKKJJKJKKIKKJKGKKKKKIKIFKKIKKKKIKJKJKKKKKKKKKKKIKKKKKKKIKKIKKDKKKKEKKKKKKKIKKJKJKKKKKKKKKEKKK>KKHKKKKKIKEKAKKEKKKJFKKKKGKKKKKKKKKKKGKKKKKKKFKKIHKKKKKKK?KKKKKKKJKCKJ@KKKKKKKKKKJKKKKKKKKKKKFJKKKKKKKKKKKKKKKKKKKIKKKKKJ4KKKKJKIKKKKK4KKKKKEKKKKKJJKKKKKKKKIKKKKJKKEKKKKKKKKKKKKKEIKKKJKKAKKKKKKKKJKKKKIKKKJKFJJKKKKKKKHKKKKKKIKKKKKKJKKKKKJKKKKKKKJKJFKIKKK@KKKKKIKKKKKKKKJJKJKKKKKKKKJKKKKKKKKKKKKKKKKKCKKJKKKKKKKKFKKKKKKKKKKKKKKJKKKKKKKKKKKK=KKKKKKJKKIIKKKKKKKKKFKKKKJKKKKKKKKJKKKKKGKKJKKJKKAKKAKKKKKEKKKKKKKAKKKKKKKKKKKKKKJKKKKKKHKHKKKKKKGKKKKKKKKCKKKKKKKKKKJKKKEAKFHJKKKKKKKKKKKKKKKKKKKK,KKKKKJKKKKKKKKKKKKKKKK.IKKKKJKCKKKKKJKKKK@JKGJKKIKKKKKKKKKKJKKKKKGKKKKKKKKKKKKKKJJKKKKGKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKJKKIKKKHKKKKKKKKKGKKKKKKHKKKKKKKK?KKKAK=KKKKFKFKJIKKKK>KKKKKFIJHKKKKKKKEKKKKKKKKKKKKKBKKKKJKKKKKKKKKKKKKDKKKKJIKKKKKKKIKKKKKJKKKKKKIKKKKKKKKKFKIKKKKKKKKKKKKKKKKKKKKKKKKKKK?KKHKKKIKKKKKKKKIKKHKKKKKKKKKKK@KKKKKK6KKKKKIKKKKKKJKKKDKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKJKKKKIJKKHKKKIKKKKKKIKKKK7KKKKHKKKKKKAKKKKKKHKKFKFKKKKIKKK&KKKKKKKKKBKKKKKKKKKKKHKKKKKKKEKKKIKKKKKKJKKJKKKKJKKKKKKKKKKKKKKKKKKKHKKJIKKKKKKKKIKGKKKKJKKKIKKKKKKKJKKIKKKKJKKKKKK&KKKK&KKKKKKKKKKKKKIKKEKKKGKKKKKKKKKGKKKKKKKKKKIKIKKEIGKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKH:KK6KKKKKKJKKKKKKKKKKKHKCKF0HKJIKKKKGKKK8KKKKKKKKKKKJKKKKKIKKKKKKHKIKH@KKKKKJKKKKKJKKKKKKJKKKKJKKKKIGHKCKKKKKKGKKHKDKKJJBKKKKKKHKJKKKKKFKJKKKKKKKKIKKKKKKKK=KJKJKKJKKKJDKKKEK,KKJKKKKK(KKKBKKJKKKKFJFKGKKKKKKKKKK=KKKKKKKKKKKKKK2KKKKKEKKKKKKKKKK5KKKKKKKKKKIKKGKKKKKKKKKKKKJHKK @rCer/1816/25_1898_CCS ATGGGGAGAAAGCGCAGGCGCAGCGGGTTGGGTGGCAGCAGCATCGAGTAGCGGCCGGTTTGGCAGCAACATCCGCAACAGGTGTAGACAAGATCCCGCCTGACTCCGCCCTGGAAAGTCCTTTTGAAGAAATGGCCCTGGTGAGGGCGGCTGGCTGTGGAGACAGAGCTCCATCCTCCGCCGCTGGAAGCGGAACTGGTTTGCCCTGTGGCTGGACGGGACCCTGGGATACTACCACGATGAGACAGCTCAGGACGAGGAGGACCGTGTGCTCATCCACTTCAATGTCCGTGACATAAAGATCGGCCAAGAGTGCCATGATGTGCAGCCCCAGAGGGCCGGAGCCGAGATGGCCTGCTAACTGTGAACCTACGGGAAGGCGGCCGCCTGCACCTCTGTGCGGAGACCAGGGATGATGCCCTAGCATGGAAGACAGCGCTGCTGGAGGCAAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCCTCTGGCCATGGGCATGCTTGCGGGAGCCGCCACTGGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCCTGCTGGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTTCTTCCTCCTGGACCCCGCTCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTCCCCCCACTCCCTACCCTCACTCCCCACATGGGAAGAAGCTGTCATCCCAGGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCCAGACACCCCCAAATCTGTTATAGGCATTTATGGATACATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGGCTTCGAGTTCCGTAGACACGACATGAATCGGGCTCTCTGCTCTCTCGTCAGGGAGCTGGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGCAGAGAGCAAGGCAGGTAGGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGGAATTAAATGGGAGTTCATCTGGCCTGGGGTGGAGGCCAGGATCAGACCATGGTGGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGGAGATGTGAACGTTCCCTGGAGGGAAGTTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATACGTCCATACCCAAAACACCCCTGCCCACAACCAGCTTCCTGGCTGGTACCCATGATAATAATTGAGCTGAACCTTGGGGCCCCTCGTTGGGGAACAGGTGAGTTCTATTTGAGACTTCTAGCCCCAGAAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCCTTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACCTTTACACCAGCCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCCTTTCTATCCCAATCACCAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTTGGCT + GH8IJHG?BIGCFHIIBIJKHIIJ4IFGKJJJICIGFKJCJGBGKJGHDAKKEKEEHK>KIDKKHKKAIHA@BEID@JIJGKIKJ9ADG9A>KIGGGFF?>JJK=KKJJKAIGGJEK@JKKJ=JIGIKI@JFKJICJGAE%FKGHKEGDKG,B>BFIIIJI@DHCIJH>BKJHIDEGGDKJ6JKKK?HBHKHACKJJIKHHKJIIJKKKGFBJJIJHIAJJGJ8KHKJGIJIGKCGKJIJBCJGJ6GFG>EF7HHBKGIDD;JHHIJGKDKKJFKIFJJK>KAKIKK=KHEK?JHHJJKKKKGJJK@KKJJJJJK.JKGFCK>8GKCFHDIDCKKK;IHIKJK0KIJJJKKKJIC;EJKB?KIGKJIJBKH-JJH>IIKJKKKIIBIJKKBKKKCFKJ9KF>GKJKJJJHH9GG>KIJ0IFGHF:JHJIKKKKJKJKGKKJKK@FJJIKJJDKHJEK@HKJJCAJIBGDFIFGIIHJ0KKK4JKKJHBJIJ.IDIFEEIKEGJ?KKBBBJKHKKFKIKKJHHIJ?J:EA@/IJIJIJBKCK@E3HKH;HKJIKKK:KKJJJKJFKKIAGKKJJDKKKJAIJIIJJJEHCEJEKKK=HFDIKKJJK0KIKGIIGB;KKD3KJJ0KJIIICBJJJBK,KKJIIIJJ@?3FEE?IHHEDHJFKKKKKKGKKCKJGJJ4KKJHKHJGJDJ=KBJJKKKKHGHKGHHK@KHKBI?KK;KKFKEJKG>K1KKHIKJH>JIKGKKJEIHJKJ=CHH;,DHIGJ>H?IFEGGKGFKIJ?IIJAKKCCIJJIK@IKKJ9KJIFBJHKKFKJKI7HFB@:HEIKJFCIGGGIIACG?DKKJJH1BEFIIIKJ=HJDJFJGDFGHEIBKJ>=HKI@IBEDK;EIIKKIJ5KGGHHJIBKKG=GJ;JKKJ?KHIDFKJGHIICCIIHGH;?H3KGKF'EE@IJKJ?HEJHFJCGAEBEEJGICKJBKK3G@IHI:JDFFJHJJGBDKFEI:KGAJBKJAHJICFFBICGEJJKDK6FJHIKKAGDAIKJGIDD:HFIII@HBH7FHIHIJJ@FJFGFGH>F=IIID9HJJGICFHKFHDHFEAF>=B@EEF4:GECKKCKIJ?FBC:JEID@DFFFKCIKJHK3JKJIKKG?JIHIHKFKF7HHCJHIGJJHIJEKK:KHH@FECHGGHJGF/KFHKJHIFIKGEHIKHGKJHA(JIIKHKKKKC?JJGFDAIHKKIGJHICKJKJ?FFBBDK.HFFCJHHCF=JGKH?KKHIFIJKFGH8GJA>@HKKKD@EEFEFIJI.B-KFKH;HKJFC:KJIJJFKKJ,JJKGHHCKIKKIJFKHIIHHFCJJJBJKJHKI>@9@C9-7>;7:838(085=14;.7<99@6:8<8.%8:>A2;?(<>,?.?=A=C9==8>7>C2AB<>97?;/==.@AB<.8>=:CFGCCA>?FG@>'DB@@><>@B2>>AA;5>ABCBAGE1?@DJD>C?I&<>:DHB)AHE5BC@?C:.D==E;CFDG?@C/GB=@D0DC>*=C?=@E?:5%B@FDDF?FE9>1>2=6ADDBD.A58<445==8=?=AA@;$8;8<1E=922=271A/=@?9?8;D@=B?EA@=846,EGE3AD;>4A;4/1<&6*?>D=9C<;B@2@??.&=&E>EAD5BD66?::3=2?-@B;=CE;@:>==<62EBABB=63>=9;73AFE?+<1?@:?;>7*75?2A?E==:@8?0?4<8GDA>2$37C???BA<885B=>>@9FCBAC>@A:<@4@3:9'<@9,EBAFC>677;@;EEFFDA?46%=09;?/@A?962<9FE<@>B=@E;=>=/757@?<$7<=9<*?>?73:A=DC?86;ACD@A6D?A?<@-39;G=AE;?;?AC>C@@:9>0?:@:9.::>+=D43=;7:778::58*@B5A5A>5779:4;>BAA7;;68=9BBB?>-7CC:BC@6>?>:;8=8A99689=;49/072;A>?)@6;0?A688@5:*665@@:7?B87170@A@BB?A>??BA:7?7>?0:>:8<555A7>9=@=;;8,7C1=>BB8;-;85?B%'/78734:569/:9.<<768;32:;516327:860:79@:7<@>BC?>=8:/=;74<=5+<<91>:/9B@==7<=2<>;46=?9?>=:7*=..95@=84;;8A=:A/765;8+AC=.-<::%@;4475557=>:.1406A=BC?A?>9/9<;A718=>B?8?;5-5567A<:?@;:7<8>:845.75<5=974>;58982:<::3;<==6:<;=9=:::917;%05*289=97.=6719<51=:891728;+8=381:;;:8989492)045327$7628=8;?5197?4<7;:073:7<5>=3??89?82=290=?>6<4:<9=5778>>4>8;;8397;3/856>0;8>0<9=<5;<);?<3===.7:5,9-:7;892=;873:29<=209<>:99:69>82:?82?9:7:;98<6>>;=9>:?4<8:28+6>?;;:?=::9:=<<6>277&30;:=>=932<;+:2>=2<16>7-67<93)8:74471+59121;;54-73*3652$+9375378;;977424::68.3/1615349/323:6:6127:4571484:5:;::8:52,3.05587;481869333665-7-134.038424/484*034:629659;858585347:30'96.05:7932423.:1:86..9465%5936::;57144:71.8:75/59525:::7596*88%9+2/45)29948-74&06.3431/(15547,:;:792,8849693.898422.:001+,)0+.,302:46:98:;69.33/8/6-9//3:5523:6:;78.425&3,4::,859361562369:7/858667359:2/)50144%/3/+%$**%'*+))45,8348::76315652%999-85::810-99:.;2:522313:/7:;455-369)225:+16:67::6341/5779268:8+448/*4145.2-+%2 @rCer/1819/1604_66_CCS ATGGGACGCCCACTCTGCGCCTACCGGCCAGGCCGGGCACCAGCGGGCGGCCAGAGCCTCAGTCTCCAGCGACCTTCGCCTCCTGCTGCCGCCCCCAGGCCGAGCTGCGATCCCACCGCCGGGGGTGCAAGGAGAGGGAAGATCTGGCCTCTTTGGTCCCTTTGCGTGGGCTCTTCAGAGCGTGAGCGCCGGGGAGGGACTCAGGAGAAAAGCTTGGGGGGCTGCGTATTGCTGCTCCCCAAGCTGGGCGTCAGGACCACCCCTGCCGCCCCCACCGGCCTGACGGGAGAGGAGGGAGGGCTCGGTATGGTCGGCTCGCCTAGCCAACTAGGTGGCGCCTGAAGAGCTGTTCCATGGTGTCGACAGCCCAGCAAATGGCACCGAGTTCCTAGTCTGAGTGTCGGGGTAGGTAGCAGAAGAAAAACTAATGCCTGCTCTGGGACAGTTCTGTTCGGTGCCTTTTCTTGTGTGTTCTGGAGCTCACAGGGTGCTATCGAAGAGTGTTCAGGTGTATACGATGGAGAGTGGGAAGTCACAAACCAGGATCTCAAGGCTGAGTCCAACAAAACATGGCTGTAGGGAGGCCACTACAGCTGTGGTTGTCACTGATGGATGAATAGCTTTTGCCAACTGTGGAATTTAGTGACTAAAGGCACCTGACCCTTTTATCGCATCCTCATTTTTCAACAAATCGTGCTTCCTGGCTAATATCAGCGTGTCCCATAGATTTATTTCTGCTTCCATTGAATAGACCTAATAAGTATGAGAATGAAGTCAAAGCCAACAGGCAGAAAGGATTGAAAACCTGAAGAACCCAGCACTCAACTGTCTCCACTTGCCTTTGCTCTTTGTTTACCTCTTCTCCTTCTGGTTTTTAACAGCCAAAGCAGAATTTAAATTTGGTTATGTTGCAAAAATCATTTCCCTCTTCAGGCCCTGTCATGTGACTTGATTTTTTCATCCATTTTAGAGAAGCTGCACCACCCTGGTTTCAGGACACGGAACTAAATTTATTAGAAAGAAGCCACTTCAAGTCATGAAGGAGAAATACAAAGATTCTTGGATTTCGTTGTAAGAACTAGAGGGGGTTTCTATCTCAGTACTGTCTCAGAAAAAAACTGTCGATATCACATGCGTTGCTTGAGAGGTACCTTTTATGACAACTGAATCACTCAGTTTCAAGAGGAGTTGGGACTGGAACCAAACTACTTACTCCAAAGCCCAAAATCTTTTCCACCATGCCTGTGTGTCTGTAAGGCTACACAGAACGCATCCTTTCTTACAGTGTGAAGCATGGGTACTAAGCTCTTTAGGAACAGGTGTTCTGCGTATTCCTGGTTCCTTTTTATTTGGAACTAAGGAGATTTAGGTCAAATTTCTGGGTTGTGGGTTGGAATTCCTGCTTCTTTCTTCAATTAAACTGGGGGGTAGCAAGACTCTATTCCTAGATTGTTAGACAGCCACAGCTTTCCACATCTCTTTTTAGTCATGAAAAGACATGCCCAGAGTTTGAAAAACATAAAGGCAATTTGACTAGT + 0133145+55032(45401251*3-6-5.3323-02.4.53-.564+56/61/0-06343-13424,/102-3062441'21*153'26134242-02.4345/51'2/4354.54344+312311036340/03664311*,4/5,41520.$5-+12/0+&--1262,*(02/2/05421-&452/*',10,.4501/41542)./24*103/52665*23/054564351,1/245,3/42-21'--.1250-3)-/00$045352034*+5.446253,44/'12,450/.'112+/,-/&0%-402160304,3,-/32%322133246401-*/5632*.0/30%5/0-41/0.44520366-.)/24,)30/(1%0*4626554/320,++034164533).%20100+4*23442,243+/0/.445-).55,15036051510/5001.+566223-444430.1&354//.025114-541$/1522+20-.-1.422254-.1+203'244213.3/+3+2-),44613124//32325.605300346321/,/+)))-20.&*'/.2,.2.0-0.)'110100...0)-+-*,+-,*,$)%.2-0,+..01'+0-1)*0-*1,.-01,.1,100.2/1,1./00,+.-,%00()-+0.,/-10-.10010'01(,//&,1.00,,'1+,00-.1+0.+.//101/**,,+'()..+&%.0)+/00211-0/*--.0/--.)*,%)2-0,)-+),0,&.-&+&*/2.1/%2.0,*#'-+(&&-+%$&-,+-'1,002,/0,-/,*//,++.-&0.0*,.,'/-*&.((11(1.000.*%)-&*('..2+.10*.)),/,0/-/(1,-*&2-20,-/1).+--)./,//,-,1),.0/.000/01,01/01+.-%)-1+1/1*-.+)-101-+-,,,/&.,---01%-'/-)+01.*.0/*1.11/(++-$.020/0,12*+00.*,,,.+0/1.-(#//(-/%&(*,%*($)-)1//&.0-,-+,11//2.-,**&--101-.+/-)1/..-1-,0-2-1./'/10.))*+/1.-),/('%**,1/1..,/&,-,,,'',)+-.-$++/*1.,)#/,+./,*/02--/010,,)10/)-,01,++,,.%/&-1/.$///0//,//0&(1,1.2/1-1)-1$./&0/.*0+..$(&%+2+/0*1,-,'/12,0//%,/0--%++11)),/.((*),.+.-+102021+$'+)$*&0$/,,/+-)-,&,,-0+,.+111010-++-2010,00'.,,,**$*.'+%.*/%/./%+--)(,.1+-,,-*.*1)-/.+%+,,#1-.%,(.+0-*+,0/)02.1,1/#%/',/02.0,-,//)2*2001202.1.-/110/&+-*./'1-00,/-+,..-(+,///),%%*'%%/(0,*,*+0('-(*01-)-2-,.-+(..$,-./.+..&&-/0&,0100,0..-$//-.*+))$)1-011'+)-/-$&%+11+-&--,.0(+.**,0- @rCer/1820/1248_87_CCS GCACGACGACGCTCACCACTCCCCAGAACCAAGTGGATATGCTGCTCCAGGAAATGGCAGACGAGGCGGGCCTCGACCTCAACATGGAGCTGCCGCAGGGGCAGACCGGCTCCGTGGGCACGAGCGTGGCTTCGGCGGAGCAGGATGAACTGTCTCAGAGACTGGCCCGCCTTCGGGATCAAGTGTGACGGCAGAACCCGCTCTGAGGTTTCCTGGCCATAGCCACCCTTCGAAATGCTCTCTGTGTGTCAGAGAGATACTATACCCTAGAAACTCTGAACACGCCAGAATGCTGAAATGCTCTTCTACCTTTGGGTTTACAGTCGTCCCCTCCAGATAAATTAAGAAATTCAGTATTTCTCCACTCTTAGCTGGATTCTGAAGTTCTGTATAGCTCGTAATGATGGTATTTTTATAGCAGCCTTTTAACAGAACTAGTTAATTTGGTGTATATGAATCTTTCTCGAAGATCTGGTCAAAACTGTATTCAGTTTTCTGACTAGAATGATCAGATTGAAGGTGGTTGGTTTTTATTATTGATATTATTTAGTGTGATTGGTAATATCTAGAATGGCAGGCGGTGCATACAAGTTAAAGAGGGGGGAAAGATAAACACCATTCAGTGTATTAGGAAGACTGTGCTATTTCTGTTTATCCTTTGGGTTTTGGTTTTTGTTTTTGCCTTCACAGTGAGACTGCAATTGATCTCATAACGTATGTTATTAATAAATCTCGTCCCATAATTTATACTGAAATTACCTTAGGATATTTTTGCATAATGCTCTCTTACTGCTTACATTCTATACATTTTTCATGTGATAATTGTCTTTGCGTAACTGGGAAAAATGCCGTATGACTTCCTTTATTATCTGGAAAAATTAAATTTGTTCGTTTATATTTTCTACTTACTAAATTGAGTTTTTAAAAAGACTTAGAAAGTGTGACATTATACAGTGTCTTTCAGACGAACAAGTTTATAGTTATTTTCCTGTTTCGACACTATTAGACGTCTTATAAATTATGCTAATTAGCACGGCAGTCTTGTTACACACTCTTAACATTGCCAAAGAACTGTTGATTGTTTGAGAAAACCCTGGGACTGTGTGTGTGTAGGTTTTGTTTTGATTTTAACAACCAAAAATAGAAATAAAATTAGAACTG + KKKKKKKKIKKKKKGKKKEKKKK5KKKDK1KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKIKKKKKKKKKKKKKKKKKKKKFKKKKKKKKK3KKKJKKKKKKKKKKKKIKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKK@KKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKBKKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKEKKKKKKKKKKKKHKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKJKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKBHKKKK5KKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKFKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKK @rCer/1821/2084_116_CCS CGCGGATCTTTCCCGCCCCCCGTTCCTCCGACCCCTCCACCCGCCTTCCCTCCCACACTTGCAACCTGCAGAGGCCCGGAGAACACAACCTCCCGAGAAGCCCAGGTCCAGAGCCAAACCCATCACTGACCCCCCAGCCAGGCGCACAGCCACTCCCCACGCTACCATGGCCGAAGACGCAGACATGCGCAATGAGCTGGAGGAGATGCAGCGAAGGGCTGACCAGTTGGCTGATGAGTCGCTGGAAAGCACCGTCGTATGCTGCAACTGTTGAAGAGAGTAAAGATGCTGGTATCAGGACTTTGGTTATGTTGGATGAACAAGGAGAACAACTGGAACGCATTGAGAAGGGATGGACCAAATCAATAAGGACATGAAAGAAGCAGAAAAGAATTTGACGACCTAGGAAAATTCTGCGGCTTTGTGTGTGTCCCTGTAACAAGCTTAAATCAAGTGATGCTTACAAAAAAGCCTGGGGCAATAATCAGGATGGAGTGGTGGCCAGCCAGCCTGCTCGTGTAGTGGACGAACGGAGCAGATGCCATCAGTGGCGCTTCATCCGCAGGGTAACAAATGATGCCGAGAAAATGAAATGGATGAAAACTGGAGCAGGTGAGCGCATCATCGGGAACCTCCGTCACATGGCCTGGATATGGGCAATGAGATCGATACACAGAATCGCCAGATCGACAGGATCATGAGAAGGCTGATTCAACAAAACCAGAATTGATGAGGCCAACCAACGTGCAACAAAGATGCTGGGAAGTGGTTAAATTGCCCACCCGTGTTCTCCTCTGAATGCTATCGGCAAGATAGCTCTTCATGCTTTTCTCATGGTATTATCTAGTAGTCTGCACACATAACACACATCAGTCCACCCCATTGTGAATGTTGTCCTGTGTCATCTGTCAGCTTCCCAACATACTTTGTGTCTTTTGTTCTCTCTGGTCTCTTTTTCCAAAGTTGTATATAGTGGTCATTTGGTGGCTCTAACTCCTTGATGTCTTGAGTTTCATTTTTCCTTTCTCTCCTCGGTGGCATTTGCTGAATAACAACAATTTAGGAATGCTCAATGTGCTGTTGATTCTTTCAATCACAGTATTGTTCTTGTAAAACTGTGACATCCACAGAGCTACTGCCACAGTCCTTTGAGTGTCAGGCTCTGAATCTCTCAAAATGTGCCGTCTTCGGTTCCTCATGCTGTTATCTGTCTTTATGATTTCATGATTAGACAATGTGGAATTACATAACAGGCATTGCACTAAAAGTGATGTGATTTATGCATTTATGCATGAGAACTAAATAGATTTTTAGATTCCTACTTAAACAAAACTTTCCATGACAGTAGCATACTGATGAAACAACACACACACACATAAAAAACAGCAACAACAACAGAACAACAACAAGCATGCTCAGTATTGAGACACTGTCAAGATTAAGTTATACCAGCAAAAGTGCAGTAGTGTCACTTTTTTTTCCTGTCAATATATAGAGACTTCTAAATCATAATCATCCTTTTTTTAAAAAAAAGAATTTTAAAAAAGATGGATTTGACACACTCACCATTTAATCATTTCAGCAAAATATATGTTTGGCTGAAATTATGTTAAATGATGTAATATAGGGTTTGTTTGCTGCTTTTGATGGCTACGTTTTGGAGAAAGCAATCTTGCTGTGAAACAGTGTGGATGTAATTTTATAAGGCTGACTCTTACTAACCATTTCCCTGTGGTTTGTTATCAGTACAATTCTTTGTTGCTTAATCTAGAGCTATGCACACCAAATTGCTGAGATGTTTAGTAGCTGATAAAGAAACTTTTAAAAATAATATAAATGAATGAAATATAAACTGTGAGATAAATATCATTATAGCATGTAATATTAAATTCCTCCTGTCTCATCTGTCAGTTGTGAAGTGATTGACATTTTGTAGCTAGTTTAAAATTATTAAAAATTATAGACTCC + '*(1-9>>;?9>;48837:8(/629778%-7<>>-47&4370-4%817?.8;8%77:8B47>><>3A@>6@8;%:6<)59*;:/??/57/=?7=>:;:6;>+?<18>:94830/6628$76=$39):178<:;?:>>=;;7%4+222=;;>09%;1=842=>>>><>>:2><>;:48::82*7295+<1;=;=;1<<8375%10/47*6:?4?6,16><;>>:935:6%;:1<399*5<><97;<;6;9:&4/(--7:9<991(2+4**77+589:77.981)427:49093815'5+&,-7?5<=9-698930:0341):4459;;456&8688395?<633:>4;:<6>=1?::>=-23;12:;8<88=?900=487*6>9$9?6897-975+>4;:5(2(<<:03975356753*227:8>2??:84:248693019://=>>==*66088..%89%8=/7:=9*8+2'7'68'7=/<9;1?8:9;6:7(6473;20;:4/1923114&+*2/,3.%109;>>9=?38$:;74:;;*;,72525:.+84+5*42)6$::82::%=;;;593,2=<==?7*4;/3):1-'6-611$2;;,88387+=2:7;93560562>;)=$8;1177:85-:=?@4?7:@0@>C@3BCCA7A>>=-?7,:3,8;B<8==<75A>'077;60<84=6=9-#@5>C4%/366.:<7,7<=>5<78149/34&/(86:-'/%/6-31/8A;,&AAB<0A==<8*><=A8?3;@A96>2=?=5,.=;69+1==93=>>4+/706/:1885.57;9'3C:<63<,305-))5'507+4892799890$32%:3+:<65+::;%*8*9?6426=5>:=6<%&9.=4<;)$:.::3536:*87&87=<>-6.7>14@B=;7>B?:C?@<5><:B9??27=8;<7=9417;,2)(286:2*65*13:,76-7*;6<>>>=52;18?8;777;&2*7<7615)&$1+4+/'-+1207;0=65577+:>/4:97/4&74,56076;'7651==>>=.87;9?:><8?;::3<08/893.#/6272;9767<:<1678<46;7>>;>>>=9<:,5;-+55/4+1315399;66%3'9:48?5:=88;7+9;996=28;3-4$.4::99389<857/191:66<6;:>:879<67,.5+:2+12=7<714,-37830/45:);57<:;=877=,967061:8<)468+4216789=>??14>;<;93-77:4:?;<=9089<<<89*16)<=?.>????2/61.%76<-9,.274+=:8;2:::->36;;?:3*=>:=<=55;98-5;<->071*7:4:3687=,?:94'<89:9605825;*??0=?8797//8=>*41:3:8*7:<2;;?768<>>::<-;4--*6:)99675$*>6;46+(&',1-.77+1%12%33+*,.1+&0;39/71;3:=?1,-24,407(88219969=9:854168,;9;<(;9>6315788:4/444(%)70(.6;9(387+2507+;3115.;>.9:4:=-78137735:7:-77543,%252762,355/:7:;>;2?:<+;4):;/01::;==<=:726'*6333<<;;?8<6,;;>?13153;>>=<=.8;:0:73;06898';;;;823,14+ @rCer/1822/25_1357_CCS ATGGGGGCGCCTGCGCCTCTGCGGCTGTAATTTGGTCTTGCTGTCCCAGGCGGGATGGTGCCGCTGTGCCAGGTTGTAGTATTATATTTTTGCAAAAAGTGCTGAAATAACAGGAGTTCGTTCAGAGACCATTTCTGTGCCGCAAGAAATAAAAGCGTTGCAGCTGTGGAAGGAGATAGAAACTCGACATCCTGGATTGGCTGCTGTTAGAAATCAGATAATATTTGCTGTTCGTCAAGAATATGTCGAGCTTGGAGATCAGCTCCTCCTGCTTCAACCGGGAGACGAAATTGCCGTTATCCCCCCCATTAGTGGAGGATAGTGCTTTTGAGCCGTCTAGGAAAGATATAGATGAAGTTGAAGAGAAATCTAAAGACGTTATAAACTTTACTGCTGAGAAACTTTCAGTAGATGAAGTCTCACAGTTGGTGATTTCTCCGCTCTGTGGTGCAGTATCTCTATTTGTAGGGACTACAAGAAATAACTTTGAAGGGAAGAAAGTCATTAGCTTAGAATATGAAGCGTATCTACCCATGGCGAAAAACGAAGTCAAAAAGATTTGTAGTGACATTAGGCAGAAATGGCCAGTCAAACACATAGCAGTGTTCCATAGACTTGGCTTGGTTCCAGTGTCAGAAGCAAGCATAATCATTGCTGTGTCCTCAGCCCACAGAGCTGCATCTCTTGAAGCTGTGAGCTATGCCATTGATACTTTAAAAGCCAAGGTGCCCATATGGAAAAAGGAAATTTATGAAGAGTCGTCATCTTGGAAAGGAAACAAAGAGTGCTTTTGGGTATCCAACAATTAATCACTTAGCTTTTAGAGCCTGCAATCTTAACTTTGCTAAACTATGATCATTGATCACATTTTGATTTTTTTCTCTCCACATTAGGATAGTTTACTGAAGCACAGTCTCTTATGTTATACTAGTGGGACAAAAGGAGGAAAAAGGAAGCAAGATAAATGGATATGTAGGATGGGGGTTATTTAAAATGGAACTAAAGATAGAAGGAGGACTGTAGGAAAGAAATGGAATAATTTAAAAGTGAGGAAAGATGTCTGTGGTAGACATGTCCTTCCATGACTAATTTCTAATTGTAACTCAAACTCACATTGAGGTATGGGCCCTCCTCAGTGACTTTAACTGACTCAGAAAGATACTCCTCCACCAGCCCCACTTCACCACCGCCGTCCGGGTTCAGGGAGAGTGTTATTATCAAGGATGCATGACAGGAATGTTGGCAGAACTGGAAAGTATTAAAAAATCATTATCAGACAGTCTTGATACATATTTTCAGAAATATATTAAAAATAATAAACTAAAACCGATT + FD=KKKKKKJKEJIJJKKJKKKFKHGKFAK@KKAKKKIKKKCJG=KJBFKKJKKJE?KIHFKHFFFJJJKJKKHKKKDKH@?K:3J'JKJKKJHEKJ0KKJKKKKKKKKDKJHKKK,KKKKJKHKJKFJIIJJGKIK;KJEKKBKGKKKKJKKGK9K?KKJK@JHKJ=JHIJFKJKFFHGKKKEHKIIKKFKJIJKHKIKIKKJKFGJFKKDGKHKKKKKF1KKKKKKK>KIJKHKIEKH9JHJKK9KKKHIGAKKJKIIKK5KHKJKKJEJJKJ;KJ?KK?IEJJDHKIHJ8JIJKIG:IHJDGJK3JIJIJIJHGJK@KKJ4KJFEJHDJBHKKKJDIJHHKKIKHIKFIJ@HBJDJJKGKJ@KGEICK=7GJKHGF>KKFDJHKK?KEJJ?JFAKKJDKK3KKK3KFKKGKI7HGJKJGGKIKJ1KIJ;FJEAIGKIGKKIHKKGDJK?CFKJK:JKKKJJCKHJJ9KKKKKE:JJDA>KAKGKHHKJBKGEEAKKHHKJKIEH?BIJHJ>HIBEIHIIJJKGKIH6CJHIK0HFGKJKAKJHKDHHIGGKIKJJJIFJJKDKCCJ8KJJEKHKJBKJEKK6KJEHJGHJHCGFIBIKH?JJ@KKJKIHAH@CIJBDJKGBKJIKJKGKK?KKKJCIHKKB;KJKFKAKKIHFJJFJIKJKJJHGKJKDKHKKJBDKIAK8JIJKCKK/KKKEJKJGKFKKKJIHFKIIKGKEC9EJJHKEGKCKBJJJKKKKCI2KKKHIKIKJEJKIKJAKKJKIKKGDKKG@KKJJ?KK=KKKKKKJKKCHGJEKKIKJKKKJKKKKCKKJHKKJJIKKDKJJKJK;KKKJKJKJIGKH9KKGKJE;DIKKCKKI7KKJJKIJH9IDAKHHH3I?JJJHGKKKIJKHJHJIJCJ@KICJJKKKHIDKKKJK>K1KKIJHJKJHKKIKKBGHHKHJFKKKKKJIKKBKKKICH;KKCKKC:I77071.2)677777-3661558:9;1:/97936752970+/47==7;4-48=6383816+::09;=66027+864329<:595985;;>>=?5<<=2=>2727)218>?37<;8?;<:>:<2;297<;4565$4===5:;9;1;:89>845861;:9>?=?4;:650897175>::658?=9<:0595951:9=9;?<>?=888>;<+9:6,=<8<=73(<<8,?<8?6:<9;;1=:;:7;;3>>;=<:),##%$%$'&#'#&%##%"$$&"&##%$#%&($$#%"%"$&%"636276*12733832435.66264302775/647--1'9:97770540;<944::53615725=46518369<9872385<<:3<>7884=399=>977777.5625<2<>>476;69:@=;:>=;5?A86;>7:,;C@=><6=6=><;;B?8;/@@89;???9A:>;A6:?<;/B?=?8><9<*:=>>5<==9>:>>;@:67<29;6<;>AC=9?;A=@A61:<:<;@8=68>=3>B65-?@<6>92-/=@=?CC>9B@>@6@5A2=?B<<?;>83.9;;/;96;9>=>7??>16=98>:<=;<,63=>>>A@=@??><<7<=@==.>?<<<8@CBC:@<8(688=A7::;@A=BA?A=1A?BC>A96BC8?B8;@<=6>B>.45>9B=B>=C8>?;;A?@@@>+6=?C?>B>5:C9>??A4BB9A;@>>>4C6/02<:7==9:29889<.<>=9>?;>;98>=6<5969><?>663<:7:>>4>::75488>3=33>52=29=):97<8<77678886+6:.2;48858:33*36/842=36926;8:===66385=:8:;-:8<:35204.4.6.5953-38345,6484;9724;70428=47788>7=;<<7;8=:8,,03'9830158=:3=8=8:=;>9=<087786:92+*0355+:::79<=8/9;:;9+958<=575%;95956/*67>=6655.<3*.0+268398958,614787676,89,1+4;079;:93;:65920:4433%572/56-5=<55+47095;98991/1.4,3>=:58=9;:86*:;-6990;:3;89<<<.=99;37:::&14>?>>>5.6:;<;;';>=723:'==<954/1%:86-;6;=:8-:6721363:;9>:;;8)8787,<28=5669==;==99<9<46:::=2;6<4=9>9?888:29<8817:3=.76<17>91<=?;92:><>3<<+8#5?9=;:?==71=?>>:>;79:=?:;5>9??<<;<7:88:519:1>==:6>>=;=96(8:=749;7=79;;4;=;?=5>2::<=1::;:=9518:/8:;:66=<>=/99=:6>>6;*641:16>988=?1?:=<=:;2<2;7<7?>>9:>??<0:9%4 @rCer/1826/25_1729_CCS ATGGGGGGGTTTGCTGTTGCAGCAGGAGCTGGGAGGAGCGGCAGCGGCGGCGGCTGGAGCAGCAGCGGCGGCGGCGGCGGCAGCTGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTGGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCTCTACATAGACGACACCCTGACGATGGTGATGGAATTTCCTGACAATGTGTTAAATCTCGATGGACATCAGAATAATGGTGCACAGCTAAAGCAGTTCATTCAGCGACATGGTATGCTTAAGCAACAGGATCTAAGTATTGCCATGGTGGTGACATCACGCGAAGTCCTGAGTGCACTTTCTCAGCTTGTCCCATGTGTTGGTTGTCGTCGCAGTGTGGAACGCCTCTTTTCCCAGCTTGTAGAGTCTGGAAATCCTGCTCTTGAACCCCTAACAGTAGGGCCCAAGGGAGTCCTGTCTGTAACTAGAAGCTGCATGACTGATGCAAAGAAGCTTTATACATTATTTTATGTACATGGGTCCAAACTAAATGATATGATAGATGCTATTCCAAAAAGTAAGAAGAATAAGAGATGTCAATTGCACTCCTTAGATACGCACAAGCCAAAACCTTTGGGAGGTTGTTGGATGGATGTATGGGAACTAATGTCCCAGGAATGCAGGGATGAAGTAGTTTTAATTGACTCAAGTTGTCTTTTAGAAACGCTAGAAACATATCTACGAAAACACAGGTTTTGCACTGATTGCAAAAATAAAGTCCTCCGAGCATACAATATCCTTATTGGTGAACTCGACTGCAGCAAAGAAAAGGGCTACTGTGCTGCACTTTATGAAGGCTTGCGGTGCTGTCCACATGAGCGACACATTCATGTTTGCTGTGAAACAGACTTCATTGCACATCTTTTGGGTCGTGCTGAGCCAGAGTTCGCAGGAGGGCGAAGAGAAAGGCATGCAAAGACAATAGATATAGCTCAAGAAGAAGTTCTGACCTGCTTGGGAATTCATCTTTATGAAAGACTGCATCGAATCTGGCAAAAACTACGGGCAGAAGAGCAGACGTGGCAGATGCTTTTCTATCTTGGTGTTGATGCTTTACGCAAGAGTTTTGAGATGACCGTGGAAAAAAGTACAGGGTATTAGCAGATTGGAACAACTTTGTGAGGAATTTTCAGAAGAGGAACGAGTAAGAGAACTCAAGCAAGAAAAGAAACGCCAAAAACGGAAGAATAGACGAAAAAATAAGTGTGTGTGTGATATTCCTACTCCCTTACAAACAGCAGATGAAAAGGAAGTAAGCCAAGAGAAGGAAACAGACTTCATAGAAAATAGCAGCTGCAAAGCCTGTGGCAGTACTGAAGATGGTAATACTTGTGTAGAAGTAATTGTTACCAATGAAAATACATCATGTACCTGTCCTAGCAGTGGCAATCTTTTGGGGTCCCCTAAAATAAAGAAAGGCTTATCTCCACACTGTAATGGTAGTGATTGTGGATATTCATCTAGCATGGAAGGGAGTGAAACAGGTTCTCGGGAGGGTTCAGATGTTGCCTGCACTGAAGGCATTTTGTAATCATGATGAACACGGTGATGACTCCTGTGTTCATCACTGTGAAGACAAAGAGGATGATGGTGATAGTTGTGTTGAATGTTGGGCAAATTCCGAAGAGAAC + AA0ACCCD?)=($>;):7A::@6$7C:D>@D6>=4<5.A3#8=).58CB>@C?$;:)4>9A@;=59B7@>0:68@>?<@.8AD@@@163A;?AA56<6B=+:<0@<;;99@;C=3D(DDA>E@:>AB8>D?A?:FF?9(EFD?GDGAE?H:IJBGAGEDEGEF@G9>?H@FDFBE:<=;HF>D;?I>EC@DF@@=:JIHIHG8EAI9D>B<I=C>D*F@H5:E;<3E;6F8AAF:FIEDHIHBAAB>FHC/FD=/:7<8;,@@GGG;IIIH@?C??(DD?:EGAEG9IH@FE@JAH8GAIBGIGE;DA;IJG?F*>D@EECCFAA9:EICDBBCIBG@C4HC=HBG@9H6<:D>DB9GCDE0D?.>D=7A/AHDCAGDH@=EC@=9IGJF>7EG?:@;DF2DE@ABGA;4CA@@BGHGIFGD>&EHHBCFDI:89E=D2FDEE?5EBC@AAFBGD@FB:88GE@EEDBIJGEAE?F=GGFBD@GFHG8:FIIIBBCE&IIG(@CDGEFBBB?I?8B7BG%::D><::BJCGIHIBB>FCBEED9AIAA?AIF8FHAH?ECAAFIG:>G5EDBI?IAE>@DHFEEF;DA5;@@A@@>B:9E>G4;BC4DCAB?CF?=>EAA?4A;5=?=8?@?=@EEGFGD?D+=GEHHI@?@J6EB,BCF>=JJDIKEBFG@KD=BHJC>>E>H?DEDICD?FH@KF@KKHGKI>F;D:IHD<=EDIG19?:=@BFG?:BAB>:FHHIDHHCAGH-FDB@(EGFJ/=4JKKKB6<9DD1EBFEGDG'IHIH<.2<57-'0.<9?>>.A5/;IK?5DC'K=:IBF;HI>AA@AGKFH7IIBFJ;D;<3EE@JBJ;E>?J5DIHG?84CFA8A8B<4E;E6HFGCHAKDEE5>B9@FGG:GB?GCDBDDEFBJIKJBDI;J5H?C3KIFDHJH=FCECJJBKG9IBCHDGGFC@FJG;KJG:GFD-JJII%JJAA;BGHGCJK?BKKDIICHHJHFHKKIJKB27@G@$BHGFHJC>IFI=GA?EGEI>IIHEEB1FFFF4D7BEDC/DC=9DGCCFHE@4?/BA5<;E:EECF)@0:;;$;7>9?5@BB>@;=AA/>BCE6>8>>ECD?>6A3:8@@D>BE>;C>8?79:7;;-477<=@318482;??;798679422:<<;;:)60@A?2BA;G>E;=KKKKDKKKKIKJKKKDKKGKKKKKKKKEKK5KKKKKJKKKKKKKKKKJKJKKKKKKKJKKKKKJKJKJEHGIJKKKKKKKKKKKKKBKKKKKIKKKK6KKDIKJHKJKKKJJKKKKFKKJGKKKJKKKKEKKKIKKKK6KJKKKKKKKKK>HHJKKKKKKKKKKKK=EKKKDKGKJHKKKKKKKKJKKKKFKKKKKKKK?JKKKKKKKKJK1KKJKKKDKKEKKJKKKK:KJKHDKHKFKKKJKKJKKKKKKK23KKKKKKJKKKKKK:JHKKKK?KKK?KEKKKKKKKKKKKKKK7KKKKAK4K646=46896495<4<<7:>=1/601-58;615.:==577556>=892964;8,+65%5>5>=<;-609:;7+520.344&614=6=99:54.51*34/5598/;83:1556866<;:8(635=<9168400/0=86?==<<=6=>:8;201::;?:8;4994%;:=-196431':,>5:.8/3-4154942<91%./23098+3717032,62/5.8;>84591.151855):87:43)5;59:04844;9527359//33$6559<:9607<28805534-72989512/6/9:=7,6.#9/299764/6.&6;+::<4<98668604580:25<2067(-<5;:6912:375+96=;5::7883)49;:68%;<5==4/4;7<182127:3/:6:45*684?;8:56=7;'.746;;:5889710999:56-8/<60/2:;=32;99<8:475=43%/:<92(>697+5;<6:62641?3:6:8<=69;86%64::8585:88/5:7==>=:<1748::7475=37<442-14.86:;<9:090051::,6425.435;,3:6658).466:--67:170.+5:+=2<84:47:3;0:5960846717:,6365353*0:5/'05657,<79<8:7.38.+')),77*2(37:89:1&:6;70238,1+93791308<0'16;89:4514,7622+1+.56572/124*.05621692&99:621434085,43.4304/.4444*%/256-29:;,;858:8)1)%52-07812&72-.-/+6,4679-5$77.:<=;'56=5254.16:4172589=71*2)8371/*'&)2651.8771=3;7:7-8:55822;-6<16.4+6544'30740)4764)5.42//(,*,)9:74666,12.78249066/555&32424.14228613?9,8:>4:=67101,0889975(73863/31//61.66-6425-+--,%22-,1/-+/,/.2346(//23/112-*'.//-6&73588665032954220168/3011%268891475*213314247252656*(2//3752%0592-110*/.47564(6;97568956,35913.3371795:93588774(4270280*(59%95141/4)/4%.3/372/%(-40,0-0,00,052-85748*3492774499)22(5$54579-40367-2//./99:4179-77163+(,27,.20744633,,20*.+)')&&/1155,7:32.7,245,)2/22..200(-.2/3)/0456;796409768;554685-21$7.-0-2,2-6./60-73931220367/450&,'.)+4:6.664**269/9567352.5/1640*/.,0-1)0413.42445/'+03+:58-+-8,99:7/+:7:9865568390183662)'107*825 @rCer/1835/25_1974_CCS ATGGGGTTCCGTCTGGTTCTCTCTCTCCAGAAGATTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGCATCGCGCCGCCATGATGGGCCATCGTCCCGTACTCGTGCTCAGCCAGAACACAAAGCGTGAATCTGGAAGAAAAGTTCAATCTGGAAACATCAATGCTGCCAAGACTATTGCAGATATCATCCGCACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAACGATGGCAATGCTATTCTTCGAGAGATTCAAGTCCAGCATCCAGCAGCCAAGTCCATGATTGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATGCTATCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATCAGTATCCCAGTCGACATCAATGACAGTGATATGATGCTGAACATCATCAACAGCTCCATTACTACCAAAGCCATCAGTCGATGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGACGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATACGCAAAAGTGGAAAAGATACCTGGGGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACAAGGATGTGACCCATCCACGCATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTTTTGGATTCTTCTCTGGAATACAAGAAAGGAGAAAGCCAGACTGACATTGAGATTACACGAGAGGAAGACTTCACCCGAATTCTCCAAATGGAAGAAGAGTACATCCAGCAGCTCTGTGAGGACATTATCCAACTGAAACCCGATGTGGTCATCACCGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTCATGCGGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATCGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATGATGTTGGAACAGGAGCAGGCCTCTTGGAAATCAAGAAAATTGGAGATGAATACTTTACATTCATCACTGAGTGCAAAGACCCCAAGGCCTGCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTCTCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTGTGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATCCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTCTACTTACCTCTCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACAGGTACTTTGGTAGACATGAAGGAACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTACAAGACAGCAGTGGAGACGGCAGTTCTGCTACTGCGAATTGATGACATCGTCTCAGGCCACAAAAAGAAAGGCGATGACCAGAGCCGGCAAGGCGGGGCTCCTGATGCTGGCCAGGAGTGAGCGCTAGGCAAGGCTACTTCAGTGCACAGAACCAGCAGAGTCTCCCCTTTTCCTGAGCCAGAGTGCCAGGAACACTGTGGACGTCTTTGTTCAGAAGGGATCAGGTTGGGGGGCAGCCCCCAGTCCCTTTCTGTCCCAGCTCAGTTTTCCAAAAGACACTGACATGTAATTCTTCTCTATTGTAAGGTTTCCATTTAGTTTGCTTCCGATGATTAAATCTAAGTCATT + KJCKKKJKHKKKKKKKJKKKKCJKIIJKKKGKKKKKKKKFKJKIK*KKKKKKKKKKDKKKJKKKJKJKIKKKKKKKKHKKKIKKKIJJ?KKKKKKKKJ6KKKKKKKJKKKKKKKJIKKKKKKKKKKKKKKKKKKGKKGKAKKGKKKJHKKJKKKKJKGKKKKKKFKJKKGKCKJKKKKJKKKJKKKKKKKKKKKKKIKKKIK;KKJKKKJKKKKKKIKHKKKKKKKKKJJJ=KKKGKH>KKGKKIKKKKKKKKKKKHJKDJDKHKJKEJKKKHKIKKFJKKKCKKKGKKKKIKJFKKKJKIKKKKKKJCJKKIKEKKKJKKKKKIKKKKKKKKKJKAKK;KKK@KGKKKKKKKKKKHKKKKKKKKKKKKKCJKKKKHKJKIFKKHKKJKKKKKKKKKKKKEKKKKKKKKKKKKKKKFKKKK;KKKKKKKKKKJKKIIKKIKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKBKCJKKKKKKKKKKKKKKKKKKDKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKHKJKKKKKKKKKKKKKKKJKKJKKKKKKIKKKKKEFKKKKKKJKKKKKKKKKKKJKKKKKKKKKKKKKBKKKKKKKKKKKKKKKKKHKKKIKKIGIKKKKKKKKKIKHKKIKKKKKKJKKKKKKKKKKKKKJKGKKKKKJJKKKKKKKKKJKKKKKKKKKKKJKKKJKKKJKKKKKJKKKKDKKKKKKKKKKKKKGK,KKKKKKKKKKJ8K @rCer/1836/25_2089_CCS ATGGGGAGTGCCAAGATGGCGAGGCCCAAAGAGGTGAGAGCCGGCAGCGGGGGCGGCTGTAACTGAGAGGAAGGCTGCAGAGTGGCGACGTCTACGCCGTAGGTTGGAGGCTGTGGGGGGTGGCGGGCGCCAGCTCCCAGGCCGCAGAGAGTGACCTGCGGTGGAGTTCCCTCCTCGCTGTTGGAGAACGGAGGGAGAAGGTTGCTGGCCGGGTGAAAGTGCCTCCTCTGCTTGGCGGGGCTGAGGGCCCGAAGTCTAGGACGTCCGTAGTCACCCCGGCCTCTGTGAAGCCCCAGTCTAGAGACATGACCGAGAGTGCCCATCGCCGGCCCGGGTCCTGGGGCTCCGCTGAGTGGATCGGTGCTGGCAGAGGCGGCAGTAGTGTTTGCAGTGGTGCTGAGCATCCATGCAACTGTATGGGACCGATACTCGTGGTGCGCCGTGGCCCTCGCAGTGCAGGCCTTCTACGTCCAATACAAGTGGACCGGCTGCTACAGCAGGAAGCGCCGTCTTCCAGTTCCGAATGTCCGCAAACAGTGGCCTACTGCCCGCCTCCATGGTCATGCCTTTACTTGGACTAGTCATGAAGGAACGGTGCCAGGCTGCTGGGAACCCGTTCTTTGAGCGTTTTGGCATTGTGGTGGCAGCCACTGGCATGGCAGTGGCCCTCTTCTCATCAGTGTTGGCGCTCGGTATCACTCGCCCAGTTGCCAACCAACACTTGTGTCATCTTGGGCTTGGCTGGAGGTGTTATCATTTATATCATGAAGCACTCGCTGAGCGTGGGGGAGGTGATCGAAGTCCTGGAAGTCCTGCTGATCTTCGTTTATCTCAACATGATCCTGCTGTACCTGCTGCCCCGCTGCTTCACCCCTGGTGAGGCACTGCTGGTATTGGGTGGCATTAGCTTTGTCCTCAACCAGCTCATCAAGCGCTCTCTGACACTGGTGGAAAGTCAGGGGGACCAGTGGACTTCTTCCTGCTGGTGGTGGTAGTAGGGATGGTACTCATGGGCATCTTCTTCAGCACTCTCTTTGTTTTCATGGACTCAGGCACTGGCCTCCTCCATCTTCTTCCACCTCATGACCTGTGTGCTGAGCCTTGGTGTGGTCCTACCCTGGCTGCACCGGCTCATCCGCAGGAACCCCCTGCTCTGGCTTCTGCAGTTCCTTTTCCAGACAGACACCCGTATCTACCTCCTAGCCTATTGGTCTCTGCTAGCCACCTTGGCCTGCCTGGTGGTGCTGTACCAGAATGCCAAGCGGTCATCTTCCGAGTCCAAGAAGCACCAGGCCCCACCATCGCCCGAAAGTATTTCCACCTCATTGTGGTAGCCACCTACATCCAGGTATCATCTTTGACCGGCCACTGCTCTATGTAGCTGCCACTGTATGTCTGGCGGTCTTCATCTTCCTGGAGTATGTGCGCTACTTCCGCATCAAGCCCTTGGGTCACACTCTACGGAGCCTCCTGTCCTTTTTTCTGGATGAACGAGACAGTGGACCACTCATTCTGACACACATCTATCTGCTCCTGGGCATGTCTCTTCCCATCTGGCTGATCCCCAGACCCTGCACACAGAAGGGTAGCCTGGGGGAGCCAGGGCCCTCGTCCCTATGCTGGTGTCCTGGCTGTGGGTGTGGGTGATACTGTGGCCTCCATCTTTGGTAGCACCATGGGGGAGATCCGCTGGCCTGGAACCAAAAAGACTTTTGAGGGGACCATGACATCTATATTTGCGCAGATCATTTCTGTAGCTCTGATCTTAATCTTTGACAGTGGAGTGGACCTAAACTACAGTTACGCTTGGATTTTGGGGTCCATCAGCACTGTGTCCCTCCTGGAAGCATACACTACACAGATAGACAATCTCCTTCTGCCTCTCTACCTCCTGATATTGCTGATGGCCTAGCTGTTACAGTGCAGCAGCAGTGACAGAGGAAACAGACATGGGGAGGGCGAACAGTCCCACAGCAGACAGCTACTTGGGCATGAAGAGCCACGGTGTGAAAAGCAGATTTGATTTTTCAGTTGATTCAGATTTAAAATAAAATCAAAGCTCTC + 79'8620/5/17.210547555,5.582:938-4596)05)0076529%577/57;;>178;:4131*135335:9:>;9668<9/8<=>01250324642.8.6/=<1>=;<5/7:=60:64&7=8:39;3<>7/?;47>,23*-545639<3289.6'6-)0-3.6)118+<;66763/45:55472'40&//422-5;0>8;:==89+58-056/884462&;247487:'-5-8678;<3%62),021877<788355516<6<=2957-6:5)-13;:88998;9-6;3%%5734,97293061#.18154:52;71.1169-)#.55>=:+64(541321934*1757<=8>>092774'8:568+77:=>==61/:<:49>;-4519*3:9996:4/08=;>8::;;;2/)4<:=3;11>9569>:334<950<::15-<=83;0(4/42==567)35599==8<67;*60859+30(4(9;=:;8>=(8:4'>3?=@?/?@6@;A;A;8<:7:;432679BB=2A>B77C@,>5=B6A:4898A1:3-/*6=;;><.==>:==;3=><7=A766==3C=?CA;597876189238>=9;>37)<44/64723.6-913?1:1?;:9<447=<29.<2<;&8688&/01?:8;85<3=?:?69;2A9=9<=/?5:7:98?>,6?:78<=368:<;@>849B?A@9<9:?)/4:>>;9>?>84>:;=><;2>;::;609AB7@:7:>9?>A4>B<<,;2=C?<:>>?<8?5'7<@9-2496;8$3/:>A9=@@=AA1;7A>:=&76>;<@=>8<:>:;/74626BB:<>::925=>87:=?:5=?@?6<7962?8:?84=9+:75?4:2:56@8?8<6;736/67:=9=7:;(;=5=4<=<:::911>C?.'.-;8-A?57;1=265@CCA>?>CA:>CC=?97*5&A,8;:@?<==6421;;6=6:<85:7=A9?58?98=@=7<;62=<=::;9A;B>?94=2A6=?29/2>=<;A=;/@04*<@3:6756A780-787496;/6,;<<=9?@6;73?7:/>7=6338=2A6)7853446?9;=8A=857=@?<>;-67=8::@6-7:244A@:>>;3:;$?;3B?1::;;=6?%86@:?@0<<;;;A<=:>5=>BA5A>@>?B/5>/965@?BC:7-8*4>6:A,?;4B:<8:8<682:;<6<+823@:?=2>7@3@>19-;?8@6<:=;:47.;4?16=A;;$7#7;=?>;<=A4B<683<8;=<9;::@<5<7A;=?:=@8>?6;@BA8=<7=>A63BA=1;<>===1=76>=2396;B;=;BA8>21=2';<<<99:@=/::87;7?<0%-/5918;:595=;6830@,1>A,?=>?;/3<3658599.8249=;70;6*-346;<:687;<8==<:0:38=5>:<6@/B;:>;93.???<1*27;82<62+7<=0<2/40.<:?:??>71>=?=6>2;<@BB6=ABA=@C<8>80589>.54(3;<99;<==??=C;'@4D<28@@::@D)B=3909;9?8DA>D>A7AE@=A9>=>A=4>;9;@;76A::B<6>3;??5/073@A>==9886?;<4<;=>5>24:4..<<8@+==;6,742:+<5::?$896674A>8897=99><9?1=??3>2$=8;;1=7<99@<6A8B7=?6;6<-6661*9=<=A8@9?89-?8'/699(@>74>6:9<::<:8 @rCer/1837/25_594_CCS ATGGGGCCTTCCTTTCGGCCGGAACCGCCATCTTCCAGTAATTTGCCAAAATGACGAACACAAAGGGAAAGAGGAGAGGCACCCGATATATGTTCTCTAGGCCTTTTAGAAACATGGAGTTGTTCCTTTGGCCACGTATATGCGAATCTATAAGAAAGGTGATATCGTAGACATCAAGGGAATGGGTACCGTTCAAAAAGGAATGCCCCACAAGTGTTACCATGGCAAAACTGGGAGAGTCTACAACGTTACCCAGCATGCTGTTGGCATTGTTGTAAACAAACAAGTTAAGGGCAAGATTCTTGCCAAGAGAATTAATGTACGTATTGAGCACATTAAGCATTCTAAGAGCAGAGATAGCTTCCTGAAACGCGTGAAGGAAAATGATCAGAAAAAGAAAGAAGCCAAAGAGAAAGGTACCTGGGTTCAACTGAAGCGCCAGCCTGCTCCACCCAGAGAAGCACACTTTGTGAGAACCAATGGGAAGGAGCCTGAGCTGCTGGAACCTATTCCCTATGAATTCATGGCATAATAGGTGTTAAAAAAAAAAAAATAAAAGACCTCTGGGC + JK9JKK:KFKFKIGEKKKKGIKHKKFKIJKAFJJ?EKEIJJHKEDGF?JEGJCJIAFAHFIEKKKJI$KJ?FIHKIJHJJ6HJK2KKHKEKKHICGFIEIKI+=@IHCKIKJDKKFKEJHIFGKDJGFIGIIKKK>KKKHK7JJ=DJJH0JI%KKKKJICKJKHGKKJK>KIGA@IGCFCHHGI;KKKKJ;IC?EDKFEIJK2KHHEGE6KGGFD?AJ?>E=JHGHIDJIAAIIKKKHKHGAEB=AK3K,AB:E2D=D?KFFDEHKBK?JJJKKKKJIKHK9IF7KHCAKJIJIHIFJKJIIGFKIKIK;KKJKKHIJ3KFKAKKIHIKHIK>)KKFGF@KKK@KIJJDKKFEKHHKBKGCGK;DKG7EH=KJGG8HKKKJKJIDKKIJFHKJ2K9E5AD1JFEFHBCIKKKJIJGCIGIHKKAGGGKIKKE5FEKJKJEJKKKKGKDKDI;J8KJCKCC1KGKKKK899967?:;95=793<7='7--74223/36078<<3+;057/><:7;66654758564;=969:;0::::::<33+<95/216254564586:46<57=4:<6.6;86=459008;8>8<>8-765/:7405738+:47=7:9;<;6799+4#6=9:6293<<+6=<*2+;6-8:6999:47;955<24>::2;9<=><<7<087756=8047548.5(-841*0244.1-1+3523.30/04:==;2297;0772798:970.35:508;2324123-7.:0'4319;2?=299;8:537899>2=;<92:<82=<<7=::*9539;-/9035<<=+7.8:299=7:78=1587;.<:<:4;;89=9972=(=6;<8:479.43587(=.67::60:83=:18=37>9:675+71/:48666473262678%8=.=<8:<251:;9:69945064<<;<96==7=79:75=998;78=:<1=:<=44/5:.9.4;::9487=1)85<<9=;:6>;9636.9:;4+=<<<<<6<<<8;<96<=:898<)9;782;+50226=4:;<47:2-/$3631/1/.054866::8?=89:6;(5-,6.,33*705%699:97<<==;97;;;;88::5886=5;94==63<:=9??91;>:9=7/-591?:79:97?/.1923=967;0=<;88*3<<<216&7$/4/6;7<173240336390+/+0)88416/322241,)233.,4.4413.225%.,143&.0/5031324162$054533313444*0331)0422554551245.44140141620+40.264061313.11-3/6613'/)1416335/414+2363'+123.33130,+04430+0)1/4-2.(05143+521353.*4(/2*--/.4654213/212-566422.222&$+/-)53230315*025-230514610/301051/1410+032/)-(016614500'2330531202*1/014&40*2.+336621411652 @rCer/1840/1729_59_CCS ATGGGGACCCTTACCTACATAAATATTATACTACATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCAACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAATATTACATTACTAACACTCACAGACAAAAAAACTAACAACTACCTGATCTCACAACTTTACCTGAACTAGCATGCATAATAGCCTTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATTCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTTATGAACGCACCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGAACTTAACATACTAATTACGGCCCTCTACTCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + .-110+/22.0,1200,01/20+1.0'%+.)0#.0.--'01,,-102-0,1001,.1/.,(-,0.0.20011,-.-2...0/1/210.111211-100/))./220/.10001+-/0/111.,*+/,-,00/1-(./)11/.*1210-1/*0--+$./200/.-&+0,/./%+/-)*).00/0+1/,/2//0+/1-1.2.1201001.,-,+%))+/.++02.,,//.,(+%,,,.*-0+/1-11,.-1+.00-0100--+00..0*-1/-20*0/*00.0'*2)111,-120*0/*.//-$*2001--+-$&,'/$1/1/10)+00+0/-//1,/0/10110,./010-('/,0.,.000*)22,100)+0.-(.0+-.110-*-0,210+)100,/,--,./01*1-/1/+1,.20)2/2-//*.+/'.,2/0'/0,011120.1..-(0)20001-+,-200,.0/++%.+*)%)++(%&)*$+(&-,+/-,+-%*(*(*,(+),.,-,+*)$)##%%),'(,)---()---,(++++%+(--,*-.((*,#',,,-'+,+-...-*+,(,--,+(&($*(+--.++-+.,,-,++*,++%+,($%*%,*'**'*+(,+.,+*',+,)$(,**$**+'*%)((+,-'+)*-)(*(+,&,,,)-**+,**&%)(+('&(#)*)'#((,+-'++++,'&'%)$,-)+)-(,-,-)+*-.,)+.+--(*('++++((,+,''',-',+*--++-'--.($*++,),*,*,'('----+*-,((()%'+%(*(-&&'+-+,-),,+,.)'(+*+'*$(+,),**+#(,)-++*,-+--,,*&$')+**$,,,(,,,+&)(%+,,+,,,--.+-++*&*&&,*%,+),+-+*,+'-)(*+.,,,+$,--*+--,*%,)&+',&,,*)(*-(++,(*'*(*-,,-*.,&-,*-,+&+--+--,+))**$',*),--.*,--,'),+,*(.)-.,+*&*#&+),%$,.+++-+.+-,++--*$+((,(++,*,'+$++$+,++++*,'-,,-,)**-+)&,,+--+),*'&)(,.*,+,,+)))*)+--+,,*,),*)&)#))(,+(*)-.++-)+.--.--+--.+-+)+++..,*#+-)--,++'(,,-.-+-+--*+,*+)-,)*)(-,--*%+-)-,+,%-++(,('(),,''(),-)+-+'#,(+)$(---'-,.+,*,+-),**)+,(++.---,,)&)(+)-),+-++'*,',))-,+,-+(+&)*%(+.-)-+-+)+*)-,,%-+,--)'$#*),,*-+*)#'++-,.+)++)(*&%$$&*,*))+(),**+),+*..*+(+*',-*-++*(()*(+,-,(--,-(&#,,-)-+)(*)+*)-)+---+*),+,,+%())((('$+''%#)-(+&,),+',+-,,(,,-,-*+-,((,)'()*++,')',*,*-)++,-))'(+)),+)-'()&*+*)+-.+*%(+'*'&'%*--*(,&,,*(,.,+-,--+-',-*-,,'&,$'((',*,-+),.+,,+.),,,+(,*,+,,,,++(''('&-,--+'*+,$,(---++(,+----+,,+,',*++.,.+-)#+-+%+-.+(,-+(-)--,-+-.,-%,--++-,*&-+,*-+-+*(()&**-,-.,-.,)'+,', @rCer/1841/27_1791_CCS GAGTATGGCATCGAGGAGAATGGAGACCAAACCTGTGATAACCTGTCTCAAAAACCCTCCTCATCATCTACTCCTTCGTCTTCTGGATCACTGGGGTGATCCTGCTGGCTGTTGGAGTCTGGGGCAAACTTACTCTGGGCACCTATATCTCCCTTATTGCCGAGAACTCCACAAATGCTTCCCCATATGTACTCATCGGAAACTGGCACCACTATTGTTTGTCTTTGGCCTGTTTGGATGCTTTGCTACATGTCGTGGTAGCCCATGGATGCTGAAACTGTATGCCATGTTTCTGTCCCTGTGTTCCTGGCTGAGCTGTAGCTGGCATTTCAGGGGTTTGTGTTTCGTCATGAGATCAAGGACAACCTTCCTGAGGACTTACACGGACGCTATGCAGAATTACATATGGCAATGATGAGGAGAGCCGGGCAGTTGGACCATGTGCAGCGCAGTCTGAGCTGCTGTGGGCGTGCAGAACTACACCAACTGGAGCACCAGCCCCCTACTTCCTGGATCATGGCATCCCCCCCAGTTGCTGCATGAACGAAAACCGATTGTAATCCCCAGGATCTACACAATCTGACTGTGGCCGCCACTAAAGTTAACCAGAAGGGGGTTGTTATGATCTGGTAACTAGTTTCATGGAGACTAACAGGGAATCATCGCTGGAGTGGCGTTTGGAATCGCATTCTCCCAGTTAATTGGCATGCTGCTGGCCATGCTGTCTGTCCCGGTTCATCACGGCCAATTCAGTATGAGATGGTGTAAAGAGAAGTCTTTCAAGAACGACGGAATAAGAGACCTGTTTTAAAAAGGAACTGCAGCAATCTTTGAAAGACTTCCAAAGAATGTTAGAGCACAGTACATAATACACCTGCCCTGCTCCCTCTATCCCTTACCCCCCACGTGCAACTGACACTCCACCCAGTCTCTGCTCCACCTTTCAGCCCATGTCAACTTGTAGTGTCCATTTTGTGAAGCCTTGTTGTGCCACAGGAGTGTAGCCAGGTCCCCTTGCAGCTAGTCCTAGTGAACCTCACCCCGAGGCCCTGCATGGGCCAGCCCCTCCATCTGTACTTGGTCCAACTGCAACTCATCATCGGTGACTGGTTATCACACCATCGCTGGCCCCTTTGGGCCCTGCATGTAGTGTGGGAGGCTCCTGTTAGCTCCTCACTGTGGTAAATGCCACACACCTTTAAGTAGATAAGCAGACGATAATTATCTGTTCTTTTGACTTAATCTCATTTGGTTTGATTTCCCTCTACTAAGGCTTTTCCTACCTTCTTCAGGCTGCCTAAGACATGTAAAGAAACACATCGATAATTGTCCATGAGAGAAAAAGCATGTGTCATGCATGAAGGAAACTGAGCTTTAGGTGGCCTCCTTGCTTGTTTACATACCTGGGTAATGCTCGTCAGGCAGTTTAGTGCATCTTTGCCTCTCAGTTGAAACCTGTATAATCCTGTTACAAAGCTGTGATTGTTGCTTCTTCTCTGTGAAGGCCATGATATTTTGTTTTCCCCCAATTAATTGTATTGTGTTACTTTACTACTTCTCTCTGTATTTTTTTTTCTTGCATTGACATTATAGACATTGAGGACCTCATCAGAAACAATTTAAAAATGAGTGTGAAGGGGGAACAAGTTCAAAATATTTTTAAAAGATCTTCAAAAAATAATGCCTCTGTCTAGCATGCCAACAAGAATGCATTGATATTATGTGAACATTTGTGATATATGTATTAATAAATAGAGCAATTAC + (*,,*&&)(%&'(%$(*)$*+(+)&+('$+%$&,,('))*-%+(+))*($(,++'%+++(&())-)-,+,()*+%,*+(%%,))'+*+&%'%&'&$))(,))++&*&('),*-%'&%)&&(+***)--,',,,*(-(,-($'*'%%&#*+)*,)+(%#)+'$%(+-(+(+*'$()*&("""$%$#(()(#%','+$&)'#**#'+,,-)*(('*%',',,+&%(+-).,)(,(-,&((*)+*+&%)*-,,(+(+-+*-',)()-*+$$$)&(%,)-(+(%&&*,'++(()+*%'*+&$&%#'*$#(*&$&,,),''%"(+&**&)('%&'))$%%%'*(+()(&,+--,(,-,,(,,&+$+&)'($''*(+(''%)((+.(*(-+20.1)(*-0**.02*,($%"'&'0.((&),),%$$)%'-,,&*,')($('')''+'-+-,*((),)('%,--,),(*,,&&()),)(+)&(+*&(&$$*&(++*,)*'$%''%$($%'%'*'((+,,,%,+,*'-,))$%((')+&#(*,,*,&&()'*'#$))+*,&(&-*,+*'$*)))*,-+*'"$%%$%*,&$*-+-*).+.,,.+-,&$+,,.,-*.,+#("###$(*&#*(-**(*&%((%(+*-*&+,)*#())')('"(&%"(*(,&'*,$(*((,))*%,(+(&((-)(),-)*,,(&(%((,*,$'()$()'))**+%&%&'+$&(----*',,$)*+.(-)#(*+(&/++&&%"'/&+'0,++/-,1++$%&'*/*-(0++.00-),+*-/+''(&$%'',.1/*,0*'$(+*'(+-.,/00/,/-&)**/101/0/10,/01+0&*(0/0&-0/,/,1&0+)*'/-*/((((-/*,.(''.1,$%'-'''*-&)(%*&#%(#%#'$(*,,/.+&*+,+(%'))%1*)%'1/10110+**/.+&,'+,/+(&'.,,/+.#+-,*-/)01-**(+*-+/+***/+....-,+*/+)++)##'+-1-/1//-''+,(,.+(/*+*,11,,(&($*(&)&-(--'-)*+)+..-.22)*'&&$*)**,++0-1,',.'+-1/(.(-(,+**&+)&&*.(-,-++,)')%&%&(*#&')''*%(*()+((&'-.$.(-0-+/0/,1,,,.1*,/.111,-$$*,&(,+((--)+.,&&&%**)()&(%+-('--),'''**'$#)#&#%,',++()(*-*+'&&$%&'&&+++&*##'%%&%(+,(*,,,$&,)&%&)','+)%""''#(&&$%&(&#((*(%+*)((&,+-*.*&((+*-+'+(,''*)(&*)&'%($""%'&'''%'%($$+##%&&-,+%%$)(#+)++%&+(%'$**&'*($&(+*',&)'(,(+($,.-($&'$(&(),,%(),*)*$%%)%$$#$(,(-)'"%(##$#$#%##$#$('((#'((*(+)''''&-,((,,(()*$*,,,**(&%"#&(++)*+&)+*'##%(%&&'#'$(&+(+&')(&&"'**$-(&+(%&%&*'&(+,($()&#$#&'%'&,**(+$#''&+*&'%&$$()#)'(&(+'&&$#&+++)-)*,,+,,+)-(+$*,)+'%'('%%(*(&,.+&)*)),,*'++(*$)$####%&$(%*%*'+)&')&#$%$%((&+*%)&#$+'/',.*(-1-*%,**),11+1/$,+*,-.)/),*/.0-1-1.,,,1/)+,&.-+-++2.,.,(/-*+,$'$$&+,,,0'+,)%%##$%'%"(+)(&)(*&**'+('+$()&'&$ @rCer/1843/1721_58_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + =KKKBIJKJKKGK?KKKJIKJKKKHJKHDKKKIIEKGJKIKKKIJKKKKK6KGKIKK4KBKIKJKDC:IJKHKKKJJKKI?JKIJAKK;KKDI=J;FHJKKKJKKKKKI&@.JE@GJHAIJKKEJKGJKIKKKIBK4JKK6KJKE>JK;IDKK3:JIKKKKKIKKKK*IKGKKK6KKB@@E@K(HAKKKKKKKJEIKKIKKKKKJJJKKK4JGKGKKJKFKKKK8JKKJKKKKKKJJEHKKJHKIKBKKJKKKKIKKKKKKKKK?KHCKDGKDKKKKKKKHKKKFKKKK;JKIKBIKFKK@HKKK=KKKHKGKK:JKDKKKKFKIKKJKKIJGKH&7KJJKJKKKJK:KKKKIKKKKKKKKKKKK,H?.KKKIKKDHKKKJHKEBAJKKKKKJJKKJKKFKKKBHKKK+JGJKJKKD=JKJ9KKFKCJK,IKIHKKKJJKIKKKKKKIKKBKKI(GK9GIKJKJKKK>KKKFKKKJKKKKEKKDJKKKKKK9HGGKIKKIFKKKJKKEJ0KIIKKKI7JKKK:EJ?@KKHGHKJKKKKKIKJKHKKKK3KKKGKKKKIKKBKKKKKKKKKKHHKK=KK=JKKKKKJJK?JF@HKJKKKKHKJFKGJKKKKKKKKIIKKHKDK&KKKKKJKIKKK9KKKKKKKKBJGJIJAJJKJFJK1IKK8IDIKJIKKKKKJKJHKKK/KJKKKKIDEKCKKJJKJJKJKKKKK&KKJKJIIKFJ?KKJKKKJK6KJKKFIIHKKFIFIJIHKCJIKKKKKKFIJKKKDKK9KIKJKHKKKJKKKKIKK@KJKJKIKK@KKK(JKKDKKKKK8KCKFKKKKEKKKKKKKKKIKKKKKKKKKGKK5KKKKKJDJKHKKKKIKKKK;KIKKJKHKKBK?KDJKKKKKKKKKGKKKJKKKKKK>KAKGKKKKKJKJ?KKKKKKIKKKGKKK?KKK>KHKJKKKJKKEJJKHJKJKKKFKJJJJGJKDK@KKKKKKKKGKIKKKKJKJKIKKK=JIIKKKK)KJKKKKKBKKKHKKKIHBIKDKKKKKBKKKKKKKKKKKKKKHH8IKKJKKKKKKBJKJ@JKKKGF@KKKKKKEKKKFJKKIKAJJKJKKKGKJHKKJKK@KKJCKKKK6@K>KKCHKKJKKKJKJK1BA?CBIGGIH.CC9DFECIFHJ7FFBCGIHBJCHKJIFBGIHIJ?FBFHGHHCEB>?EHCKFAKAGDH==?D<@CIEH9G@@:6;ICB>EIEDI@??=E<77A=>E@FBIJKKIB<6FCBCHEBJGBH:IHGIHHHHEIDJE7C?ICGJCDHAG:ADD=AJH:D@GHEIHFFCC9I;?:8AAHJI@ICB7GAIIIIGHFE>GBKGC?IJHIGI>DHCJDD?AF?IHBH;9K=?FDJKJFFCIIHFGK2IHKIF??GKJFFJIJCG>HB=GDD@G4IB@I>CDHHHI>JHFFGJGAKGJFKJKKFGIFIDBEB@CIJIK@JJIJGIJKFKHDDDH@KH8IACGKGKHBDBB3G8GFIEI>I6KHIHBEHHJGHI>HHAAD;?F9GI/BB5<;8H;JDDICGJJI8KK>GJEJHFG;8IFFB8-;&9AIKDKJJ5JHGDFGG@AC3@HDEDJAGAJGHKGH:GHIG@II;F=?9CDIFJH5GIFAKHJJ@BDIIDCII5JCHCA@C?2GEFG??EJF?D:HDK@F9#CCFG>HEFKJCIGEGECH;@IFJFHJIJ;KKKJ;IE?IJFKKGKG=HDHD?>D=HHIBFKJJFHJDC=G?H@BKCHDHJKJKCJJJJCB<@BB5H7GHH7AD;F@EDJ>HJ;>@KFDFCIJ@G;DFC5EDFGEIGCH;KJKFKI;IJEKG@H=31894@?:;GIHJH@DFKCBH;JG@@F@II:=CEABDD@D>>=BG>J>@D9IJHH:CFD0@FAFBA>?EAGBHID9(EEEH;DEFKCF=I@>E:I@?EBCJGFI=;2E4>DCBDGI@H?JE>CA;*=C@F@HHHA?A@FAG?GFIBH?B/,1GE979DAEF=<:>BC<85=BA:9*-123@BD5@6BDC?C@/@?ADA7C@:>98147CB@>0972120<03/484-.$656;3:<;.35/37866@A;@=:<<9A?9@;>4=::;4=<99%66<<57:;7=9:B:G=>D7B?EEHIH@IBIHI;=EBJ;<8F7GBFI?GEHB>AA<;*C0;IIEAC>?=BDAB&ACFIHF8IE8B>? @rCer/1856/1633_67_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAATTGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTTGT + KKKKJKKKKKKKKKKKKKKKKKKKKKCKKKJKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKJKKKKKKKKKIKKKKEKKKKKKKKKKKIKKKKKKKKKKKKKKKKJKKKKKKKKKIKKKKKKKIKKKIKKKKKKKEKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKHKKKKJJKKJKJKKJKKKKKKKKKKKKKKK?KKKKKKKKKJKKKKKKKKKJKKKKKKKFKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKJKKJKKKKKKKJKIKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KIJJKKKKKKKKKKKKKKAKKKKKKIKKKKKKKKKKKKKKJKKKK3KKKKKKKKKKIKKKKKKKKKKKKIKKKKKKKKHKKKKKJKKKKKKFKKKKGKKKKKKFKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKIKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKGKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKK@KKKKKJKKKJKKKKKKKKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK)KIKKK?KKKKKKKKKKKKIKKKKK>KKKDKKKKKKKKKKKKKKK/KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKFKKKKAKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKK?KK6KKKKKKKJKKKKKKKKJKKKKKKKKKKJKKKKKKKKKK;KKKKHKKKKKKKKKKKKKKIKKFKKKKKKKKKKKKKKKKKJKKKKKKKK4KKKKKKKKKKKKKKKKKKKKKFKKKKKKKKIKKKKKKKKKKKKJKKIKEKKKKKKKKKKKKKKDKKKK3KKKHKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKJKKKKKKKKKKKKKKKKJKKKKKKKKKK@KKKKKKKKKKKKKKKKKJKKKKKKKKKGKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKJKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKJJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKJKHKKGKKKKKKKKEKKKKKKKKKKKJKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKIKKKKKIKKKKKKKKKKGKKKKKKJKKKJHKEKKKKKKKKKKKKKKJKKKKKKKKKK @rCer/1858/0_2963_CCS AAGAGAGACAATGTAGATCAGTAGAGCGCACAGAGCGCAGCAAGTACAGGGAGACGCATGACCCAAAACCACAGAGCACGCGACACAACCGCCATCCGCAGAAAGAGCGCTTGATCCAAGAGCGGCATGCATACGCAAGAGTACCTTGCAGACCAGCACCATCGCGAGAATTGAGCTCTATATCTAACTGAGAGCTCCTCACACCGCTGACAACGTGCACCGACACACATCAGGACCCATCCTGTCCAGGCTCAATGCGTGTTATTCTACGCTACTGCGCAGAAAAGACACACCAGAGCGTGCGGAGCACCTCTTCGGGACATTACCAGTCTTGGATCGTGCCACATGTCCCCTTCGCGCTGGTCGCTTGCTTCTCATTGGCCGAGTGCGACCTATGCGGGTTGGCTTTGTCACTCATTATACGCGGTGAGTGCGTATCTGAGCCAGAGAACTACGAGCAACACGAAGAGCAATTGGAGAGGCCCGGCATAAGGAAGACATGCTACAGAACTGACAAGACGCCACCCTGCCCTCCGATGGAAAGAATATTCATCAGAAAATTGAATGACGAGGCGAGATCCGCGCGGAGACAGACATGGATTGAGTCGACACTAACACGGAGACTCCACACGCGCATCAATCGTGAGAGAATACCACTTCGCACTTTGCAGAGGAACACCTAGGATGGAGGAACGCCCAGCATCTAATACCTCGCGATCGAAAGAACTGTAGCAGGAAGCGAGGAAACCTGTGCATCGACCCTATTTACCCCGACTCTCCCAAGTCTCGTCTAAGGCGAACATAGTGGAGAAAAATGGAGGGAACTAAAGTACCGCGTAAGGGGATTTCGAGAGTTTGGTGCTTAGATGTGCCGGAGACGTGGAGCACCCGGCAATTAGAGGTGCACAGAGAGCATCAGTCTAAGGAGGCATTACCTGGGCAGCCTGCTACGGAAGGGCAGAGCGGAAAACACGGAGCGTAAATAAAACCCTACGGGTGGTCTTACACATAGTAGACTATCTAGGATGAGGAGAGATGGGCGCAGTGAATACCCCAGGTGCGCACTGTCTCTTACTCCAGATTTTTAAGGCTGCAAGATTATGGTCAATGTAGATACTCGCAGATCCGCGGAGAAATCTTACCTCGAGGGGGCTGCGAGAGGCATCTTTTAATCTACTATTTCCCACCATAAGGGGTACCGATTGCGCACCAATTATCATGCCTGCATGACTTACTCTTTAATAATATAACTACTCGCCTTAAAACTTTAATCCATTGCCCCCATTACTCTAGTTATCCGAGCAGAGACTCTTCCCCTAACTGCCTTGAGTTGATTGACACAGTCCTAAGGTCCAGGCAAACCACGGCAGCCCTAACCGGCAATTTCTTGTGCCAACAGTCTAAATGAAAGCAAATAAAACAGCAAAACATTCAAACTGTCACTTTCGTCGGAAGTACATCCTTACCCCAACAGTGGCAGCCATCATTCAGTGGATGTCTTCAAGGGGCAGGTGCACAGAACACCACTACTACGCGGCCCTCCACCCTTTTGACTTCCTTATTTTCGCTCGCTGACGGTACACCGTCGCGCTTTTAGCAAATGGGCAATGACATGGTATAGGCAAGCAACAGCTCAGGAGATCCACGAGGACGTTGGGTGGCAGAGAAAGACATGTTGACATCTAAAGCTCTCTTTGTTATTTTTTATTTCTGTCCCCTTCGTTCGATCACCCATCATCCCTCCTAAAAAGTGACTTCATTCCTAAAGATAGACAGTCAAAGGAGTGGCCTTACTGCATTGGAGAGTTTGAGTAATGTGAGCATGCTGAGCTGGGCAGCTTTACAGAGCCCACGTGGGCAGCACAAGAGAGCGGGAGCATACGCTGACCACACCGCGAGGTCGTGGCTGCCCACAACACCAGCTACACGAATCATGTTTAAGCTATGAATTCAGCGCGCAGCTAGGAGACAGAGGACGGGATGCAGAAATGAAGAAGCGCAATAACATTATGGATGCTGAGGGAGCATAGATGCAGGAGTGGAGCGAGTCTAGACAGGCACCGAGACAAACAGGTCCTCTGAAGAATATTGTGATGAGATAGATTCAAGCAGCGGTCCTGCGTGGACGTCACTAGTTTATGCCTTGGATGTCGTAGCATGAATGGAGCTGACATGCGTGCCCGAAAGCGACCTCTAAGACAACACACCTCGTTCCAACCAGAGCCCACAACGCCCGGAAAGAGTCCAGGTAAACTTATACGACACTCAGAGCAGAAGGAGAGCCTCTAGGACACCAATCGCAGCCTCCAGTACACCCATTAGACACTGCTTGACCACTGGCTGCAGGCAGCGAGACAGTGCAACATGCAGCACAACCTCCCTGAGAAAGATAACCGGACTCATACCACCTCCATCACCAGAAGACCGCCGCGTAGCGAGTAAGCACAGGACGTGCACCTGTCTCCGAATCACCACCGAAGACACAACGGCTGAGCGATGCCACCAGGAGACCGAGAGAGACGCTCTTCTGAACCACAATCCTTCCAACAAACACCTCTGACAAATACTCCATTTCTCCCCCTCTCCTAACCACTGACCTCACCTTTTATTAACGCACGACCGTGATAGCCTTCCAAAGAGCCCACACTGCACACCCCTTCCCCGAAGACGAAGAGAAGGATATCATCTGCATCCAAACGCTCTCTAAATCCCAACTCCTAAATTCCGAATGTTTCGTGCGGACTTAAATATCAATTCTAATTAATAAGCCATCGAAGATGAAGGTTACGAAAGAACAAAAACTCCAGACACAAACCCCCAACATTTTTCAGACAGAAACACTCTGCGTCGCGACTGAGGTCGCTCTGCCATCCAATACGTGGCCGCACCCACAACAGCACGTGCTGTGACGAGGCGAACGGAAAGGTGTACAACTGTCCTAAATGAAATAAAAACAATAAACT + !)#'**'*,&,$+(*%#$)&*%('$%('(*#$$&&$#(()+%%++%*+((''()*)&*+**&+%#$$%$##(&((*,,,*,%(#&(#%&&()-*,)+)*#'%###'$))%$%$)'%)#)''&+'$**+%,&('')$#')'(,&((#-(.)-'(-&)'%%,&-*+,)%("'*()-.*.,.+..---$)-/..(-..*,&-%*%'(.,-.,,*$,,%+,$(*-,*$*($))*-,,+'%&+#&'+,&,)(,++-..#..)--)-,*.,.++),#-+,,,'+),%++%&*+'%#)&'**%))()**),(+,-(*(-*##,')''+-,'-+.#,+*))'(---,,)%,)*,+%+$$'+)-,-.--**+,--.,',-&+*+++(''%$)&'')&*++(,%*)*-)))+*,+.-%+,+,,,...,,+,--#-)*-,",-+,,++-'*##(#)$*(,&,(,*+)(*,")#(,-(+...,#-..--*-..+(*)+*.('$'**(''&(,,-,,',(-#+,-,'+"(-'*$(,%(*-,+$'*')-*..'&&&&$$#&'-...,-,-'%%*,,-+#.-,,)((#$$&')+#&#'%($#&)$+*,**")')-+***+%+)+('+-'-''--,-----#)$#,-',,*+*-(.*.,,*,'&$'-.-(#..(..-(),**+,--)$((#&(&%,(+**+--')*.$*/.),-'#,,"##$).-+**.*,---.-#%--#-..,.(-.(%*#--&,-'-&&.+,../'//*+..)&..",(*,$'*-$$,,$"').%.--&--*)*)&-$(."'--.-+),)'))#%##&+)&(&$'$,$$(&+)($&*))+##*'%%*,+&*,)('&)&$'(*-)*(',)$*-,,).,&,-%+),+%+++#$(-,)#(-*"-,-#--(,*,---(*+,+---..-#(--+%+%+&)++(-,'(&&+,%.-(.-)-+*%-*'%.**,+,,(&(#,)-.+)-,,')'()%()#&'),,)**++,*#,-('()).-)-+,'*++#,,-,+,-%&,-,++&---.*'$,((%&$'&,$&'&',(",'*($-(--))(*+%+**-&-,*-))('+')+%,&'+&-,-+-,$)$++&,,,,*,-,-+*.*+)--,%+)((%),)&,$-,,-*---,+(#%)%,++,*&(*+).-*,'('&&&$++&$''+(,&*,-*+),'-*((,%*%-'-#,+)++*),#)))'(-%+,(.%,-)+,++,+,%''(%*#*#(&(',$()-)%)(&%,*-&&%-,$+'%$*&-.+&+&("#*%-(--&*'..),)"($--)...*&'$'%$(%%(%-(.&-$'+'$,..$+."(&+#',.#--(--#%,,-+%--'(%#+',)&-&-&,%(,+%-&+&**'.%&+,,,-'-%-%'&-+,"-*&*(,'&+*.)&.-*,(.,.,$%%$'&+%-.($..,'--,%$&**+,"'&"&#$")+*#"%#%$#&+(%+-&))""!$$"!$!#!"%+***+'.,.-+-*%+#$"%%%*$'+'$)(*#"$!%()'#!#!!&#!!"#&'+'-,'),#%$()--(%#+*,%"-&--),,,*#)&++'%#---(-*#+*(,,*%&'*)-##(-(-%(#&,)(-&#)'*&&))%.#--.)'...../."+$&$-*'..).,,.)#*+*+&.-,/-...,$-..)-+---/.//)-',""-+-*.&#',.+$$,&()&)#-&.)-+-'()*-.*$+--+""%"%)&#,%"#"$&,'.-(-#).,-+'.#---'(%),-'&)/-.)&.*)-,")/.-.*--*#*'*-).*.'--)&&+-&%&+*#*+('--*(%%'*,+-,(&-/+*)$&%#%+&+&*+"(+$*#&&'+$#'.)-...$---+%&)*)-#%-&,%$%%+-&+*$)#++'&)"'&,*,+&+.$,(&%,+#**+&&#"$$%%#(&%#')''#%#&#---,'(*(,,..#$.,-)#"%%$$%%$%"$(*##(*,$$(%*)+&'+$%"$#'%$%"#(,"$%#($%(&$-)'(--+.**%(#(#*''#'##)#$$$#($%%&()$#)&,'"*#+#)'#%($"(*$+%*#,,(*)$%#,-*(..),*#,%#**.$+--.-",#,,.).*-$$'&)-',#*,,-&+-,**,--(&($%%##'&$"%"#*#(%#&$$##$'"""$#"##$'&#-),'$((%#$*"#""%'##%**-*#)'&(('--&()&*/,+((+"'+..(..',...".-.$+%+(+""$.-+)..)''(#+--"#..-"%(-(#.-,.,/.**-*'.+&-&-*/.#&+-..&.""-.)/'-&*")...."..),.),'.,'.*.*&-,$*+#+#).((/.,/.*+/+.-.#."..*+..+$.+$$%"&&,,%)**''*/../,('*-.(,&+/--"(.//-#,-.(.-)/"-*#+.,(*.).(/-&.-/*('*-*('.$)'-.../-#,($-./,.,+#-,"%'(.)#.*++'&+#*",--&#.'.)/..---,-.-)-"'+%((*..*'-.---.-."..'/-..-.$.,/..-#/*.,,#(#%)%"!"$##)*&,'-&#$,$-&).$+),-$%&#'+,*").,+&,/,&.)-('"++&.)(&-.-.#&&&,(/(%,.(+#/*.().(,+.,*/&.()+..-#/"-...(()#)))%&($%#-+./*&/*./&.,+/+.+//%/.+#+,)'%&..+/++.+-)(-+)+.$$%%$)+'*"(#()((.$#+%$,&-'#-&#.),%(../'/$-,'.(*,'-&+.#.+*/#./$&,"&--)$*%+-+-"(&-.+&$**$&-.**/.(/./.,).)($(-%&..,%*(.-.,)/..)$-/*.-/.,.*//-/#//+///,"/././.-,/..$*#+-)/,/,&*.%*$&)-,&(*,%..-//.-//.,...,'%*#&(.,*-,(.--...*-+$*...)..,).**)%(,((%#,&#+-*(-,+ @rCer/1859/25_1544_CCS ATGGGGTGGGCTGAGCCAAGATTGGCTGAGGAGAGAGTTGCGATGGCCGGACACAGTGGCTTATGCTTGTAATCCCAGCAGTTCGGAGGCTGAGGCAGGCAGATTGCTTTGAGCTCACGAGTTCGAGACCGGCCTGGGCAAACACAGCGAAACCCCGTCTGTACAAGGTCCTCCTCCAACTCCTCCTCTCTGCATGCGCCTCAGAGCTGGTACCAAGAACTGGAAGTAGCCCTGGACTCAAGCTCCGCAACAATCAATCAACTCAATGAAAACGTAGAATCATTGTACAGGAGAATCCAAGGATCTGACCAGCCACTTGCAATATTCCTTGCAGCGTATTGGAGAGTTGGAGCAGGCTCCCTCTGCTGTCTCCATGCAGCAGCAGGAAGAGGACAGGAACAGTGAGAACAAGAGCGCACCGCAGTTGGAGCAGCAAGTAAAGGAGCTGCAGGAGAAGAAGCTGAGCGAGGAGATGAAGGAGGACATCTGGACACTGAGGAGGAGGAGGTGCCTCAGCCCATGTCAAGCATCCTGGAGGACCTGGAGAGCCGGGAGGCCATGTGTGAAAAGATCCTGAAGCTCACGGCTGATGCCAAGTTTGAGCATGTGGCCAGCCTGTGCGCCTGTTATGAGAAGAAACAAAGCACCTTGTAGAAGCACTTGGGGTCTGCAACCTACACAGCGAGTATGAGGCCAGCCAGGGTCCAGGCTCATTCTAGAAGTTTCACGCAGCATGCAAAAGTGCATGGAGAGTCCAGGGAGATGACTTAACCACAGTCACATACTGAGCAGCTGCAGAGCTGGGACCTGGCCCTGGGTCTCCTGAATCCACGGACTCTGTGGTGCATCGGAGGCTGAACCCCTCTCCCATCCAGCTTGGTGGCCATCTGGCTGATCCACTCTTTCCAGGTGGACCCTCTCTCCTCACGTGGTTCAGGTCCTATTGCAACACCTCCAGACAGGCCATGCTAGCCCAGGGCCTCCCTTTCCCTACTACTCATCCCCCAACCCCAGAAGTGCAAAGGAACCTGGTGCCAGCCACAGTCAACCCCGATGTGATGATCTTTCTGCCCACCCTCTTTGATGTCTTGGAGCTGGCCGCTGTCTTTGGCCAGACCTGCAAGTCCGGTCCTTGGGGGTGTAGGAGGAAAGAAGCCCTGGCTGTGAGTCCTCGAGATGGACCCTGGCCCTCTCTGGCTCTGAGTAACCTGGAAAGTCGGTGGTGTTGGAACTTCCGGATTCATTCCTCAGCGTTGAGGCACTGTCTGTGGAAGCCGTGGGACAAGCTAAAAGAATATCAGCAGAGGAGCAGCCCTGGTGTTCCGGCAAGAGCGAGACGAAAAAGAAAACTACTGGCCGTAGCCCTGAGACAACCACTTCTGGTGGTTGCCACTCACCTGGGGATAGCCGGTACCAAGAACTGGAAGTAGCCCTGGACTCAAGCTCCGCAACAATCAATCAACTCAATGAAACATAGAATCATTGAAAACAACAGAAGAAACAAGTGGAACATCAGCTG + --',,-,.22/1110,/000/&./2,(0/,,/,1/&*+2110/-,1-,-01,01-0-,/.$-(-010/11*/,,/00/+,,%.)*),,-1.0,&101,2451+'1/3133-04314/54,04364256691:3.5.784&5350/2689.8837+/64744/,-)25;8-:847321/32547730,.1.',25)14.,866054/15150103,0548456:+67//.66914:76553756776:99;77;575:788;5890944&53286176/96::526/-669/37+572:54697:631.,6,4078849762897.82727655,%/1489.25528463835:79;8:+:3.3+637579:3:.315686:48:78(1.724,761926727.5978;9.9-61381/044515260/,.+12./550/21,153643212544,2/&0.00+240,3/545055.4/2522,3521*251134551)4/.343550.20366643.432632246011356124004314016525*3646213606505541621062-(('),*1015344/62+.1.446'31.65-.+4425236464/.6.2)/44.-3511/./,3345.340266.5552365+14023523,.(4445511416.425222*22/42-1130/2-235163043*165441.2004.5.12421364)/31051-0.4)420-)1)45130.+0414/16022/0,-/35-4.*-3+.3--/120++100120)--535400,.01+051/6/203*3,.32'-.435/)240,1.0/224412$--&1501332325*0,15203.*444./514312035)0*.-.14550561416.144(/3355-+/*0/-3112.00-1353545,/+340+5143/2-134/05.024563.4151656/321.+1'20/(+()13-0.%3)'0+&+*'*/2.-/%*,..,+'/.312*/0-03-2403/1234)34-*+$.,//23630)34455031565452512&0341.'2442,541+45124024+/33/-,036363.54--+/40451.65)-/1*.2./56.4246/1+32/1/3*/33102+54/06/$-1225210403+/1255435360)-,/2-/63565.42456413111/.%0-33+236654416/021-5656/24%2031/2,534'436/45.4626652/32515./33106541453/&1/.4160*3)55435535.462/626/5)3065+46503.415-30561110263$00.5.66664363244633*4.54-142664423551601461642.6404.55.504*32324/5544%,246322/.100446104611.*1(.2+,.4.555/63+1)/12$11652-06,3-/0-5.4/2&0311555(/..4240&0130)00.3333*30),3)/+2(1.-32(52-4 @rCer/1860/24_1526_CCS ATGGGGGGAGAGAGGCAGAGAGCACAGCATCGTCTGAGACCGGACCCTGTCAGGCCATTGCAGCCTTCTCACCAAACGCCGGCCAAGGAAAACTCACTACCATGAGAATGCAGTGATTTCTTTTGCCTCTTAGCATCGCCTATGCCCTGCCAGTTAAACAGGCTGATTCTGGAAGTCTGAGGAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGTTAAAGCCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCTTCCGAAGAAACCAATGACTTTAACAAGAGACCCTTCCAAGTAAGTCTAACGAAAGCCATGACCACATGGATATGTGGATGATGAAGATGATGATGACCATGTGGACAGCCAGGACTCCATCGACTCGAATGACTCTGATGAAGTAGATGACACTGATGATCTCACCAGTCTGATGAGTCCACCATTCTGATGAATCCGATGAACTGGTTACTGATTTTCCCACAGACCTGCCAGCAACTGAAGTTTTCACTCCAGTTCCCCACAGTAGACATATATGATGGCCGAGGTGATAGTGTGGCTTATGGACTGAGGTCAAATCTAAGAAGTTCCGCAGACCTGACATCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACATGTGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCTCCCAGTTGTCCAGGCCTGAACGTGCCTTCTGATTGGGACAGCGTGGAAGGACAGTCATGAAACGAGTCAGCTGGATGACCAAGTGCTGAAACCCACAGCCACAAGCACTCCAGATTATAAGCGGAAAGCCAGTGATGACAGCAATGAGCATTCCGATGTGATTGACAGTCAGGAACGTTCCAAATCAGCCATGAATTCCACAGCCATGAAGATATGCTGGTTGTAGACCCTAAAAGTAAGGAAGAAGATAACACCTGAAATTTCGCATTTCTCATGAATTAGATAGTGCATCTTCTGAGTCAATTAAAGGAGAAAAAAATATAATTTCTCACTTGCTTTTAGTCAAAAGAAAAATGCTTATAGCAAAATGAAGAGAACATGAAATGCTCTTTCTCATATTGGTTGAATGTGTACCTATGTGAATCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTCGTGGCTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTACGTTCATTCTATGAAGAAATGCAACTATCACTGTATTTTATATTTGTTATTCTTTCATGAATAGAAATTATGTAGAAGCAACAAAATACTTTTACCCACTTAAAAAGAGATATAACATTTATGTCACTATAATCTCTGTTTTTTAAGTTAGTGTATATTTTGTTGTGACTATCTTTCTTTTGTGGTGTGAATAAATCTTTATCTTGAATGTAGTAAGAATCTGGTGGTGTCAATTGCTTACTGTTTTCCACAGTTGTCCAGCATTAATAAACATGATCTTTTTTACTGC + 5-)975/33.'$6&662/45302465567466.3346/2&2-0--&565/53,31:-"*3318,6&4)0.0%-,588276&326)8-:'87116:7/055935250/2%4+25332+5(%&55846/42-3*'72-551;,13/'41'-8:-%*-(68.+&0.385,98'&0272&142,.-%:441.'1'2426.64&321639523)'10251)8,403,.-546+93.-5.6:6:973432+)'.-).-&67521952)-7:897/6-61-5-+5513+8'59.8:.::4:1:)751&1%$07/63552&86-6272:.44535623757(61224337*&1/-)/))(#$23/&368433/.552)-013143-+3+1/3)+)-%++64.:86467,374,%&37&40-14(03714*03313/(.31-4.&1(,-,(,01*+4+.,-1650&4-,(%83:..96/32'0&63'20/1**66616)687-78)43*(797949:544.,964,-40,3291-240((..250,-%'19:0227041/883414',,&(5%636.=6&1,*0160/8*.:681=:1/680<45$87/267;738*+229005/1:?>>02.9:>6319/9647;776+5>1+6:13054082-3'0-46*4/14*=0;;3<>8.>271>8$3.6=4:<:>9:5=0;1.#(-5(*7;93.;4,902545?5922+80<8*7)/60684544$,/,9472===588/868*;;6:=52;3;:93;4:<6<:)*1594)91;=7??24)/3>2.0;;;979:;45-52065&25.2,99=0;0,56135)61:5+;:960852;)5;5(89:53=:25=;795++):<<:>1<&59568-0958/*7+546::94%7;7;0:782;14=38=0;2.7;04=91$756.-54493=:38062$85979<9(89,;=>:6((25-(55:;:=-;/908;96:69483=91)3$+;>;45(;5&35))3:><9;3:4,7*474*7;8$9-7':9:1;99(;<6&$.39:3(5%:+(267*896*-$7.653:31*'1==49:$6*6;878-#2%.->&34/=+'-'.2,<=*4,6/6>)925A,A>/-9)56@;089%;<=7@$<+>42*;?/-'?:<:9A+$+46+@5CC3,*B>8?.0B@?4&<96:<-<57'<;:@<7;645;88);8(7BB79/$%,)/BD17.$<37919.*32+&(8='&2:*4<:8?55;65BB::69)<67:&3&%>9898*2)887-<8+A@;63@9==C9.744/(6%;<;;93-(+5-,<7*$>=95?<7372355>;8+(3<(@AA==86;6?4360;,:9,ABB<.=<3;<@.*61-B>8)<:6=>97<9>>4>31A>62'=?0(13>>7=929591'3/+8<<7.;77<7<2:%39?=3:?90&/*745.9148<9C<8+>0>;#+-/<+$89//9<6780@@=?;86=@JIHFFJAKHEG;AA7?B9DGJDDHDIKGHIHC9FBDBJ<2KEHHIBBIJ:JFKAFGHA.JKICBIF@C5@IJIJFE4>GFKD@AE-05JJJKJKJDCGACJKK:J@DI@IFAGKDJFECK5FJI?KFIKDAIIJJAFAC>4F@2J@HJJKKIIJDHDF@@I;GKJJFKIJIKHH7GFIJIFJAI4GJKKCC2GJ2GKGEJHCGKIKKKJEIAKKI;I7C9BB>IKKJ5KJKIEFJ@AKHDGKI?CJK:@GAFJ?EKKJJKHKJ=C@EDJKIB2HJJJKGJJ=:;GCIB@I@D?)HEBKKIAIJ:J@IIFJIDJHJJJKHA;>KJKJ@IDDIIEIAIBCD@FD+7=6A?HF3ACIF6?F@D>@KDAHEHJ8JJICIKAJ8I@@KKKJDKKKAEF:IKHKBI;HIDK7JHIJAEDCGCKFDBIJJGKKJGDIKKEJKKF?@@DGKKFIJD;GJFC9:@(FHGJKJKFIF@K>KKCJEDD6IJGJIDFDJHGFKCJJII>JJG;I;E6KDG6F=CIDJ-HIH5@FGKKJ4KGFKI4D=B>3B.6=DC<2?FHHAJBJBIBHJGHGK7DDCIJ2>@H8=C>985AGI@KJI@I;K6C%@DI2FKHE:KKKEC7KKFGKKKJJHKE,IHCEKKHKIIA7IHGKKJJKDKJCJI?>?F5EJKKKKCBKIJCEGJFKK?GKG9JD<0=>B7IEEIHB?(>EBBAEHHG,EKKBJKGJIKFKDKJIAKI7D7@DF;HHFKDFI6ICB@H7D@FCFIAH@6KJKFHGHGHFKJGBG?E?CH=F=FE,;HDDJEBCCKHDD@C;DJCHICE@=8:?@;;B@G>KC2D:JK3IFIHI;FGJHDKKHI:HGEJ9DH;9C9IB6J>D4=%>DC@FGD=ICJCJFJ7JIJHIABA8@=HF3JH@I5=(3>72BB?CBEHB=DJ?F:@J;JFF9:@F?AI5?:JK2KKHKHKIKKKKKIKKKKKCJIDJKKKBK9KKJKIGEKKA=H @rCer/1869/25_2178_CCS ATGGGAAGTTGGTAACAATCAGCTCAGGGGTTGCTCTGGTTGCAAGGTCACTGCAAGAATGAACATTGAACTTTGGACTATACTGACGGTGAGGTAAACAACAGGACTATAAATATCAGAGTATGCGGCTGTGGCTTTGTGGAGCTGCCAGAGTAAGCAAAGAGCAAGGAAGCAGGCTCGTTGGAAGGGTTGTGACAGCCCCAGCAATGTGGAGAAGTCTGGGGCTTGCCCTGGCTCTCTGTCTCCTTCCATCGGAGGAACAGAGAGCCAGGACCAAAGCTCCTTCTGTAAGCAACCCCAGCCTGGAGCATAGAGATCAAGATCCATGCTAGACTCCAATGGTTCAGTGACTGTGGTCGCTCTTCTTCAAGCCAGCTGATACCTGTGCATACTGCAGGCATCTAAATTGGAAGAACTGCGAGTAAAACTGGAGAAAGAAGGATATTCTAATATTTCTTATATTGTTGTTATCATCAAGGAATCTCTTCTCGATTAAATACACACATCTTAAGAATAAGGTTTCAGAGCATATTCCTGTATATCAACAAGAAGAAACCAAACAGATGTCTGGACTCTTTTAAATGGAAGCAAAGATGACTTCCTCATATATGACAGATGTGGCCTTCTTGTATATCATCTTGGTTTGCCTTTTTCCTTCCTAACTTGCCGTATGTAGAAGAAGCCATTAAGATTGTTTACTGTGAAAAGAAATGTGGAAACTGCTCTCTCACGACTCTCAAGATGAAGACTTTTGTAAAAGTGTATCTTTGGCTACTGTGGATGAAACAGTTGAAGCTCCACAGCCCATTACCATCATGAGCATCATCACAATCAGGGACATCAGCACTTGGCAGCAGTGAGCTTTCAGAGATCAGCAACCAGGAGCACCAGATGCTCCTACTCATCCTGCTCCTCCAGGCCTTCATCACCACCATAAGCACAAGGGTCAACATAGGCAGGGTCACCCAGAGAGCTGAGATATGCCAGGAAGTGAAGGTTTACAACATCTACAAAGAAGCTCTGACGAAAGAGATGTATAAATCATTACTCTGTAAATTGCCCAAGATTCAGAGCTGGCTCCTAGGAGCTGATGCTGCCATTGTCGACATCTGATATTTGAAAAAACAGGGTCTGCAATCACCTGACAGTGTAAAGAAACCTCCCATCTTATGTAGCTGACAGGGACTTTTGGCAGAGGAGACATAACTGAATCTTGTCAGTGACGTTTGCCTCCAGCTGCCTGACAAATAAGTCAGCAGCTTGTACCCACAGAAGTCAGTACCAATTGACGCTGAAAGAGTAAGGCAAAAAAGTGAGAATGATCTTCAAACTAAATATTTGAAATAGGACATACTCCCCAAATCAGTCTAGACACAATTTCATTTCCAGCACTTTAGAAACTACCAAATTAGTAAACCAGAAATCGAAATTAGATTTGTGCAAACATGAAGAAATCTACTGGATTGGCTTCCAGATTTAAATTTTATGTCATAGAAATATTGACTCAAACCATATTTTTTATGATGGGGCAACTGAAAGGTGATTGCAGCTTTTGGTTAATATGTCTTTTTTTTTTCTTTTCCAGTGTTCTATTTGCTTAATGAGAACAGAAACGTAAACTATGACCTAGGGGTTCTGTTGGATAGTTAGCAATTTAGAATGGAGGAGAACAACAAAGACATGCTTTCCATTTTTTCTTTACTTATCTCTCAAAACAATTTATCCTTGTCTTTTCAATCTTACACTTTAACTAATAAGTGGATTTGTATTTTAAGATCCAGAAATACTTAGCACATGAATATTTGCTATAAAAGCATATATAACTATGTTTTAAATATCATTTATCTTCTGTATATCTAAGACTTATATCCTTATTTTTACTATCACACATGAATAAAGCCTTTGTCTCTTTCTTTCTCTAATGTTGTATCACACTCATCTAAAACTTGAGTGGCTGTCTTAAAAGATATAAGGGAAGATAAAGAATATTGTCTGTCTCTATATTGCTTAGTAAGTATTTCCATAGTCAATGATGGTTTAATAGGTAAACCAACCCTATAAACCTGACCTCCTTTACGGTTAATACTATTAGCAAGAATGCAGTACACAATTGGATACAGTATGGATTTGTCCAATAAATTCAATAAAAAACC + 85(557?<0<799&-107=4;37;:62=<+$7:<:9246<49+53:>:498+08,30)5==:8;8398/??9?>6,5::*17<8)66727<+'479+304/9170/2,7;::<5-68><<4-:4>:87:8=:)988639<82888::85<2*965+8492891;2>2>=>;=?70;92=+944%7:-53,/835:&9;:9>9):787,7(/,;57%9&<;;=8?;2<597:342,7940795;+<(9(5;%9-%0/=:87183)3=74;6(6.<31*1$65;=9>;3==7:8:8/8920;<-$34/474877507&5:;<8<:56+9))(,1)975=<>2:0:.8>;>27:::?=6<=3;:6?>;77>683-08<;=7)0=<977:8?/34764>:285>9?9383:4<6822)53:;314*9/<8:+62;8-+5<74+33677;&=;,04-6;87723:0995>42>7<6>98::=>;:461;);=>1'2/49/36-99,0-#55'52;57;:0=>>;87716655???.57802);1;+>4440<>8>?3;63:8:3824.8719=82::187>>*678:73.58.76>3<3<>=7=07>;76=8=2=-9?8$;5.6739532;;.;;4=<&:<1;/=:4046*,449>>>:.:><=+3::793=0?>1897<<29<<::73014.7-3-768*:82(,=64<8(:3765950795<=1<8>8>7;689:60'::405(::*;53;7;>>77$481-86,<9;6658-5:671389273636=(;:;90..&.40%+2)/3454))9:7)059<9'3.)%*,03619+9;3>7852;;;:-7:<87;8<6-09=088<>98?90=8/9/=<;<15<;-@4/<:;;=:;58+3+?=<70@2-98->A9+498<=+>;83.,3316<<3<7@<8:><1>3B@;42>9;+@;=:(;.6;:=68%??BC?A>&<=:3=;44:62*8<25)2>/:>?<=:=CC-@?2B.$67=.<>7<8A><2A27;>:9*8:698?0-=4.532.,:2,653-<1)345*4'166%>:???=?5??:@*:89><,1587%/47+99%02':;125*7/4284;>=55<8+:<49&56;4=>:A>28;3)370/7@<>27<>6=7;6:9;;;;?1?AB,>8=C@C?:548B@7>78>78;><>;;819;6;>86179A<;A=@A9A;<5<:7=A<@.3-A<8<6;>7<>%85,,087610,:A<5E@99=:E>789749==8A;@,8D@7GBA@.<4849;).3;=7>7?1?DB?-6;9=4A80DAEB=@/C9<0@A+CDA@8&=,;5=F@@FC@;+E?<=;EB4B;>;:@A;?B)<;5?C?@<<7:$:?>?A=;=/($6-*1?CBDC69?@>+>;=C$?0?D>@CA@=DE?CG@;@(?>/*?@D@@=B>4??=>*C5B@7/597%7..<@DC:AC@>C<1=>4>>->BDBB4->1975@/57.1$$36>)A9GBAB3B@AB=CCC2E?*?8<@;&=E<=C>$@;:>;)49<2<98;5>9A,BC47A3ACB?7<=2=%*3+%>C?7?7D<;CA?:C4==?3ABC=31;$,5=;52?C<=;>8?C;1?6@278/3:22>==8753;<5+.1,01',6426<@9&34=;5;<<16.794;9/',$(+2:09842(348/7/.*:5-26614/2)207-0:<>=;2//63892>9433:95/6%35495/2.7677439;6(41,1$2-4:296)'2999440;636,48.513)7251683932#186744:4935)357/,17&35:,'378::795;9)62,532$:/(35'7:784$126.53. @rCer/1870/25_2396_CCS ATGGGACACACCGAGCCGGTCTCCGAGCGCTAACGTCTTCCTGTCTCCCCGCGGTGGTGATGACGGTGAAAACCGAGGCAGCTAAGGGCACCCTCACTTACTCCAGGATGAGGGGCATGGTGGCAATTCTCATCGCTTTCATGAAGCAAAGGAGGATGGGCCTGAACGACTTTATTCAGAAGATTGCCAATAACTCCTATGCATGCAAACACCCTGAAGTTCAGTCCATCTTGAAAATCTCCCAACCTCAGGAGCCTGAGCTTATGAATGCCAACCCTTCTCCTCCACCAAGTCCTTCTCAGCAAATCAACCTTGGCCCATCGTCCAATCCTCATGCTAAACCATCTGACTTTCACTTCTTGAAAGTGATTGGGAAGGGCAGTTTTGGAAAGGTTCTTCTAGCAAGACACAAGGCAGAAGAAGTATTCTATGCAGTCAAAGTTTTACAGAAGAAAGCAATCCTGAAAAAGAAAGAGGAGAAGCATATTATGTCGGAGCGGAATGTTCTGCTGAAGAATGTGAAAACACCCTTTCCTGGTGGGCCTTCACTTCTCTTTCCAGACTGCTGACAAATTGTACTTTGTCCTAGACTACATTAATGGTGGAGAGTTGTTCTACCATCTCCAGAGGGAACGCTGCTTCCTGGAACCACGGGCTCGTTTCTATGCTGCTGAAATAGCCAGTGCCTTGGGCTACCTGCACTCACTGAACATCGTTTATAGAGACTTAAAACCAGAGAATATTTTGCTAGATTCACAGGGACACATTGTCCTTACCGACTTCGGACTCTGCAAGGAGAACATTGAACACAACAGCACGACATCCACCTTCTGTGGCACGCCGGAGTATCTCGCACCTGAGGTGCTTCATAAGCAGCCTATTATGACAGGACCGTGGACTGGTGGTGCCTGGGAGCCGTCTTGTATGAGATGCTGTATGGCCTGCCTCCTTTTTATAGCCGAAACACAGCTGAAATGTACGACAACATTCTGAACAAGCCCCTCCAGTTGAAACCAAATATTACAAATTCCGCAAGACACCTCCTGGAGGGCCTCCTGCAGAAGGACAGGACGAAGCGGCTGGGAGCCAAGGATGACTTTATGGAGATTAAGAGTCATGTCTTCTTCTCGCTAATTAACTGGGATGATCTCATTAATAAGAAGATTACTCCCCCTTTTAACCCAAATGTGAGTGGGCCCAATGACCTGCGGCACTTTGACCCTGAGTTTACTGAAGAGCCTGTCCCCAATTCCATCGGCAAGTCCCCCGACAGCATCCTCGTCACAGCCAGCGTCAAGGAAGCTGCTGAGGCTTTCCTAGGCTTTTCCTACGCGCCTCCCACGGACTCTTTCCTCTGAACGCTGTTAGGGCTTGGTTTTAAAGGGTTTTATGTGTGTTTCTGAATGTTTTAGTTAGCCTTTTGGTGGAGCCGCCAGCTGACAGGACATGTTACAAGAGAATTTGCACATCTCTGGAAGCTTAGCAATCTTATTGCACACTGTTCGCTGGAAGCTTTTTGAAGAGCACATCCTCCTCAGTGAGCTCATGAGGTTTTCATTTTTATTCTTCCTTCCAATGTGGTGCTATCTCTGAAACGAGCATTAGAGCGCCGCCTTAGACAGAGGCAGGAGTTTCGTTAGAAGGCGGACGCTGTTCTAAGAAAGGTCTCCTGCAGGTCTCTCTAGGCTGTGATGATGAATATTATGAAATGTGCCTTTTTTGAAGAGATTGTGTTAGCTCCAAAGCTTTTCCTATTGCAGAGTGTTTCAGTTCTTTATTTTCCCTTGTAGATATGCTGTGTGAACAGTTGTGTGAGTGTGGTATGCCTGATCACAGATGGATTTTGTTATAAGCATCAATGTGACACTTGCAGGACACTACAACGTGGGACATTGTTTGTTTCTTCCATATTTGGAAGATAATTTATGTGTAGACTTTTTTGTAAGATATGGTTAATAATTAAAATTTATTGAAATGGTCTTGCAATGACTCATTCAGATGCTTAAAGAAAGCATTGCTGCTACAAATATTTCTATTTTTAGAAAGGGTTTTTATGGACCAATGCCCCAGTTGTCAGTCAGAGCCGTTGGTGTTTTTCATTGTTTAAAATGTCACCTGTAAAATGGGCATTATTTATGGTTTTTTTTTTTTTTTTTTTGCATTCCTGATAATTGTATGTATTGTATAAAGAAAGTCTGTACATTGGGTTATAACACTAGTATATTTAAACTTACAGGCTTATTTGTAATGTAAACCACCATTTTAATGTACTGTAATTAACATGGTTATAATATGTACAATCCTTCCCTCCTCCCATCACACAACTTTTTTTGTGTGTGATAAACTGATTTTGGTTTGCAATAAAACCTTG + >D&;29A>47B?DEA@?97E?G@C<=958-5>;>=3?87<5C?1>@E8F@C8CGD?EAA>B,A?GDCE7?B3@8DBGEE49E@79%=EA8@7C?%@=CDB?(>>B;>>7ACC/CD=CE=FF?7A9+2>9/?C??:5CB:9>@BF?FB@:DC=D>B0+;6=CD=>=>9@@?5AD3CB;B@3A=E<@=;@B/;BC@F?CE:AA:B;>7G0CCCBC?@@:@?BGCA1=A7B9?>4D;:DE84AG6E@@>EDEC;FFD@8*AD<=E3B<>0B==C=GDAD>FEB3B.EFE;C=EE@E/?.;DD@08A7;<3@=C6C=AD?19FFABB;:;C>3BCFGEFAB;DBD2CCD@BE@C@@F=CBAD??4@DD9BE?A2>CEB17:7+;C(;8::B:8C<9>(?>?9<6AA'<<<@?><>2:5:B>AEB0F8,@24AF@9>D@B;@B?:559?:?9=AAB8B?7<=@:C>@@D;(309:<:;?>6)@CCE;:87873?667==@::B987BF<;62EDAACDB@4?B=<;=E><7<@FGFD??<(<;<;CC@AA?CBD?<;ED?==;35<>82ACE?.0;9?8<=:?79=>8>>?<4<92888/0>9=?6:>:;988;:1=72>84AABC>B?BE@>=BDD==6AAF=E@<8@<=?*;;9D:3=5576>/831750@6EC;B,6=A;ECCB8D@?;AB??4=>8FF.BDD+4=8ABEF>GC;C8;@6>2C>86DD:ABD@:56/3><*EE6A;;C?(B>6B40;AB=CA>56C2DA?BD;8EEEBBGFA;7@'A@:>A7>@FA=/?>9@AEFBCFBF;=:D=:7>:6<=,8B@BCDE5F<6D@1G>=2@<24>@.>==E6=E=;CE<=D4E@/CE2<<7<0DBFA@?D4GA?>=A%;ABEBB?DD;:=F=?:5BFEBG5?@<>0?;>3@=:ED7A?>C=/@B7@;@;A@4>FE>@EED@EF@@@8BC@+*85@>B.A>2>3B=F5<>B=.>:E83>DA2@@G(@@A5=8.D@3EGA:@A;ACC:BB@CB(A;C6@:@>F?FEF7E,=;@;C:56=>?CF6@:A<@FB@??EA@C=87EBA9AB>@:@2AA<=CDDCCFD=BE>C@=>CBAB:FFA=E@:C@A>>EF6E9BCEED3;3A<34DEEGF8GE2C=BC=:?@<9/:;>6?8@/C:=A@<@>=A5AB7D>FDGBD8C?7+>:)8D@BCC;?@DA.B<=;FA;DA6>FB=C>CF8G>;B5B>E/CE==CC>B><@6;?BCE>EBFF@<@2?;>>4AA@@GBA5>;=<@DEACCE.GC>1?B@CFD>DF=@4CFCEE=EE:E>98998'58>=ACB=3@FB>:B@BC@9<39;B7<;C?:GGFBA7BF4E>?>CBFGE=AC>8:>B?D=90434@:@.D@;B:>?9,>BB8C?@7C97>CF;BF:=30FB>:DBGF*A-11C@3%?DDCCF=EF@@FBA>=5EDEF>B?AF:EIGH@@DBHFAEAEDA?9AE97DICC;HGFGGC:BE9ED/BBB4>>B3=AF:;=-@;=$A<'4:?2=,.?7/B=;;=?=BCCA:@::;3@AA>A.BJC?AIID?:JHAIEEIC-GEB7H@IIB@@BB1F:DCJCAHDI:<<@.:BCBHIFF5EA(B?G'@=@8JG3EEF;A@FEB>AF/FFAEG>==CDBBG4>7EF;AGFGF3@ECE>B>;;'BB63A@DEADC>DC;AB:DCDFC?F@2@36?4@FG+EB9D@=4CCBCABA;@;BBECCEFCFAA7GDA8=@/F?ECBF@C9D><:D?A@9@GBF?ACB8;GDCCAEB>>@:E>FC4CDEB8AD;EADA@@@9@BE>A>+AA?C<>@DC>3D;DCBC4<>DBD8C@B;@AB@?:9@@8<5?=:?B8E?>B?DCB=>=3;?6?A?<83=>7D;@EC6BA3B>?A;7F:CCFDFAE@BE9>F?@3>:C;3@>?EF<@?DE=>BEBCDD8?>3@B;E9FG?C?@<9EE@D8?>C=A27;>;09->C3DEAGE?ABD9D:><>BDABB;EDEEDD@<@=B?DE3D4>:A7D6::C1A/9BB;ACEE<=B;A==?=,>EE?F7?FCGCCA@=DAC?DBC8@CB:?E>==*>18BC778;=-29C3<5@:>@>?7<@@??;,A;BB84ABA>=A;B67A@C@@@3?C@CA@;@?:7CC=7<=?8@5@?:*4=99=>;>?C>5<(59@@3>6BA94A@A@<9?A;:?<@3<86288A??;>@7A;2==<8<6?.<=C>=@:A>;5=;=9A6A???C;4<=<6A?@B>CA=A>:?(:=A6=:-=@@>>56+;<==?<4>A@@7A:>>:::@A=:7>:68<7698)>;>5A<>AA7>???2;AAB?BA:;/:?ACC:>:=:2@5@A@%;=7<67<:2:1;949>@9>7<:?A3A@@C7A>>?>:@A8;*=94=A?B>@B>A:=;6?AA<5?9;?;>@;(0B>:@7?>?AA<>0=A;>>(@883?56?9B>B:=@>:9=B1A<=>2??0=;5<@;A>>>@=B14A7@=A@<0:B?7BA8=@A@?ABA?>:A:?A;A8==??@5:??:;@A2A<1=7>-4*?===>)3@>A@;>8;<=<25@:?@C>3>A:AB7?>AC4B=C?A8>@4>A@=@<=?:>?>?8<91<8==./-.;<@=6??6?@=?;?A7?48*=:=&==>ABAB?>@B?>??'4@@9@?=79?=>4=.C8A<@CB@;=;986;*:3.;?(@8;=@:ABB9C93?0>B8B@B6B>@8>?>;371.3?9;=AA?:B@@A<3C@@>>C8?>>=BF<=AE?1>>B:@D9-C@?>;<=>9A7AABBAC>:@=5D=B=DB@?E>E>D;;@*9CCC>;DD@=9+DDC@@ @rCer/1877/3562_63_CCS GCGGTTCGGGTGACAGTTGAGGATGGCCGGAGCCGAGGGCTCCGCTTGGGCGGCAGTCGGAGCTGGAGCCCGTGGTATCGTTGTCGACGTCCTCGAGGAGGACGAAGGAGCTGGAGAATGAGGCGTGTGCTGTCCTGGGCGGCAGCGACTCCGAGAAGTGCTCCTACTCGCAGGGCTCAGTAAAGAGGCAAGCACTATATGCCTGTAGTACCTGCACCCAGAGGGAGAAGAACCAGCAGGAATTTGTTTAGCTTGCAGTTATGAATGTCTGGAAGTCACAAACTATTTGAGCTATACACAAAAAGAAATTTTCGTGTGATTGTGGAAACAGCAAGTTTAAAACTTGGAATGCAAATTACTTCCTGACAAAGCAAAGGTAAATTCTGGCAATAAGTACAATGACAACTTTTTTTGGATTGTACTGCATTTGCAAGCGACCTTATCCTGATCCTGAAGACGAGATTCCAGATGAGATGATCCAGTGTGTGGTCTGTGAAGATTGGTTCCATGGAAGGCATCTTGTGCCATTCCCCCGAGAGTGGGGATTTTTCAAGAGATGGTATGCCAGGCCTGCATGAAACGTTGTTCCTTTTTGTGGGTTATGCTGCGCAATTGGCAGTAACCAAAATATCCACTGAGATGATGGATTGGTGCGGAACATTGATGGAATAGGTGATCAGGAGTTATTAAAGCTGAAAATGGAGAGCATCAAGATAGTACCCTCAAGAGGATTGTTCCAGAACAGGGAAAGGATGATGTCCAGGAGGTTTAAAGCAGAGCAGAACAGTGAACCATGTGCTAGCTCTAGTTCTGAATCTGATCTCCAGACAGTGTTAAGAATGAAAGCCTCAACGCAGAATCAAAATCTGGCTGCAGACTTCAGGAGCTTAAGGCTAAGCAGTTTATAAAGAAGGACACTGCCACCTATTGGCCCCTGAACTGGCGGAGCAATGTTGTGTACCTGCCAGGACTGTATGAAAATGTTAATGGAGATCTGGATGTCTTGTTCCTGACAGATGAATACGACACAGTTCTGGCTTATGAAAACAAAGGCAAGATTGCCCAGGCCACTGACAGGAGCGATCCCCTAAAATGGATACCCTTAGCAGCAATGAATAGAGTCCAGCAAGTGGAACTCATTTGTGAATACAATGATTTGAAGACTGAACTTAAAGGACTACTCAAGAGATTTTGCTGATGAAAGGCACGGTTTGTTAAGAGAGAGGACATTCAGGCAGTTTCCTTTGAAGAGTTTCAGTCAAAAAGAAGGAAAGAAGAGTGGACGGGATGCCAGTATATACTGCAGCTGAAGTGGAGTATGAAGCTTCTCAATTCAGGCCAATGAAAATGCACTTCCCCATTCTTGGAATAAAAAGAGGTGTGGTTCACATTCGGCCCCCTTTCAGTCCCCTCCTCCTGTTTGGAGAGGCCTCGCGCTCCCTTCAATTCTCTTTAGTGCTGCAGTAGCCACATGTGGATGCTGACGTCACAGCCAGTGTCCTCTGTGACTCAGCTAGTGCAGCTCATTCCACAGACTTCTCCAGTGTACTCCTACTCCAGTGCACCCAGGGTTATTTGCCTAGTTTTTTATAAGTTTGATTTGGTTTTGAGAAAGCAAATTGGTGTCTTGTTTAATGATCTGTTATTTCACTCCCAGAAGGTGTGTGTTTTGCCACAGAGCTGTTGTCTCCCAGAAACCTCCTTCCGCAAAGCGTCACGCGAAGGCTCTCTTCCTGCCACCTAGAACCCTGCAGGTCCCCTCGCCCCTATGATCGTGGTGCCTTGGTCCAAAGCTTCCTTCAAGCCTGGTCTGCTCCTTCTTTCACATCCCTGTTTTCTGAGGTTTGGTCATAGCTTAGAAAGGATCTTGGGGCTTGTTTCTCTAGGCCCAACCTCCAGAGTAGCCGGGACTGATGGTTTCTGGTCTGGATGTCTGTCACAGCAGAGAGATTAGCAGGTGATAGGGCTGAGGAAGCAAACCTTTGTTATGAATTTCACTAATACAGTTCAAGTGAAATTTTGTTCACGATTCTACTGGCACTAGAATTAGAATTTCAGTACTGTAGCGCTCACAGGGCTTCCTGGAGAACATTTGCCAGTATACTAGTCCCTTTTCTGCGCCTAGAAAACAGACCGGGTCTCACCCCTGTGAAATCTTGGTGGTTTACGAAAAGTCCTCTGGATTTCTTGATATTATCAGGGATATTCATAAGCATATATCAAAAAATGGACCTATTTTGATATTCTATTATGAAAATGTTATTAGAACCCCAATAAATTATTATTTTCCCCCTCGAATCTGTGCTACGAAAAACAGCTCCCTGAAGTTAGCTTACTTGTAGTAAGCAGGGCAGGGAGCCCTGTTTTTGGAAGAGACAGACTGTGGAAGAGATTCCAAACAAGGCCCGAGGCCGCACGAATGCAGAGTTTTGTGTATATAATGTTAACGTCCGCCGCCGCTTCCCTAGCGACATGAGATCTTGTTTTTGAAGATCCTCATGGAAGGTTGTACAGAGCCCCACATTTGAGGGGAAGTCCTTTCAGCTTTGATATGAGACCTCTTTAACGCCCCTCAGTCTGTGGAGTAAAGGCCTTGTGATACACACAGAGCCCCAGCTTCTCTCCCTCTGGAGGAACAAGGTCTTTCCTGACAGTCGGAGACACATCTTGATGTATGTTAATAAAGCATTCAGGCTGTGGGCCATCATGTATATTAATACTCCTTATGTGTCCAGCATCCATGTATTCATATGAGTGCCCAATCCCTGGACGAGATGAACTAGGCCTTATAAAAAGTCAAAGCCTCAAAGAAATGGCACAACCATGTTCTTCAGCACTCAGTCTCTTAATTACAGATCCTCACGAAGGGTGGTAAGTGGAGCTGGAAGCTCTTGTGGCCGTAGGACATGCTGGTGAGCCCTGAGCTGGCCTTGTGCAGAGGGCTCCCTTCAAAGGCTCAGGGTGTCTTTGAGGCTGTTTATCAAGCTTGGGAGCTCTTCCAAGTCTGAGAATGTTTCGAACCCTTTTTGCAAGGTTCCACTACTAGTATACCATCATGTCCAGAAAGCTTTTAATCTTCTCAAATATCTGATGTAACTACCAGAAAGTCCCTTACTTCCTAGACCGATCAGGACCAAGTCTTGGAGGTGATGTGTTACATTACATGCAGCATAATAGTACCAATCAGTTAACCCAACGCTGAAGGGCTTGTTTTATGAAAGGTACTATTCCTTCTTTCACATTAACTGGAAACCTCTTTTTTACCTGTTGTTCACAACTAGTTTTCTTATCGACTGTATTGGACTGTCTCTTCTTGTAGAGACTGATTTTGGCCAACATATTAATGCATGTTTTATGCAAAAACACAAATACCGATATTAGTTGCTTTTAGGAGTTCTGGCATTGTATGTGCATTTTGTAGAAGTTGTTACTGGACTTATAATTACATACTTAACTCTAATCAGGTTTCTGTAAAATTTAAATAAAACCAATACAAATC + 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@rCer/1878/740_55_CCS TGACATAGCACCTGGCTACCACAGCATTGTGCAGAGGCCTATGGATTTGTCAACTATTAAGAAAAACATAGAAAATGGACTGATCCGAAGCACAGCTGAATTTCAGCGTGACATTATGCTAATGTTTCAGAATGCTGTAATGTACAATAGCTCAGACCATGATGTCTATCACATGGCAGTGGAGATGCAGAGAGATGTCTTGGAACAGATCCAGCAATTCTTGGCCACGCAGTTGATTATGCAAACATCCGAGTCTGGGATCAGTGCTAAAAGTCTTCGAGGGAGAGATTCTACTCGCAAACAGGATGCTTCAGAGAAGGACAGTGTCCCAATGGGCTCTCCTGCCTTCCTTCTCTCTCTCTTTGATGGAGGAACCAGGGGACGCCGCTGTGCCATTGAAGCAGATATGAAGATGAAAAAGTGAAGCCTCAGAGTACCCTCTTTGAGCTGAACCTAAAATAAAAGTAAACAAGATAGAGCTTGGGCTTGTGGGCCCAGTTCCAGAGGCGGAAGTTACAGAAGAGGAGGTACCTGGGCCACACGACATGAGCTGGAAAATCTCTCTTAGAGATTTGGAGTAGCACAATTGCCTGTTTTAGGGCAGAAACCATGGGCTTTGTTAATGTCCTAATGTGTAGCTAGCAGATTATAGCTAGTTTGTATTGTCTTGTCAATTGTACAGACT + KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK-KKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK/KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK @rCer/1880/2087_56_CCS ATGGGGAGTGGAGGCTGAGGCTATGATGGCGGCCACGGCGACGGCTCGAGTGCGGATGAGGCCGCGGTGCGCCCAGGCGCTCTGGCGGATGCCGTGGCTGCCGGTGTTTTTGTCGTGGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGAGCAGCAGGTCCCGCTGGTGCTGTGGTCCAGTGACCGGGACTTGTGGGCTCCTGCCGACACTCATGAAGGCCACATCACCAGCGACTTGCAACTCTCTGCCTACTTAGATCCGCCCTGGAGCTGGGTCCCCGGAATGTGCTGCTGTTCCTGCAGGACAAGCTGAGCATTGAGGATTTCACAGCATATGGTGGTGTGTTTGGAAACAAGCAGGACAGCGCCTTTTCTAATCTAGAGAATGCCCTGGACCTGGCCCCCTCCTCCCTGGTGCTTCCTGCCGTTGACTGGTATGCAGTCAGCACTCTGACCACTTACCTGCAGGAGAAGCTCAGGGCCAGCCCCTTGCATGTGGACTTGGCCACCCTGCGGGAGCTGAAGCTCAACGCCAGCCTCCCCGCCCTGCTGCTCATTCGCCTGCCCTACACGGCCAGCTCTGGTCTGATGGCACCCAGGGAAGTCCTCACAGGCAATGATGAGGTCATTGGGCAGGTCCTGAGCACACTCAAGTCTGAAGATGTCCCGTACACAGCGGCCCTCACAGCGGTCCGCCCTTCCAGGGTGGCCCGTGATGTAGCGGTGGTGGCTGAAGGGCTAGGTCGCCAGCTGTTACAAAAACAGCCAATATCACCTGTGATCCATCCTCCTGTGAGTTACAATGACACTGCTCCCCGGATCCTGTTCTGGGCCCAAAACTTCTCTGTGGCGTACAAGGACCAGTGGGAGGACCTGACTCCCCTCACCTTTGGGGTGCAGGAGCTCAACCTGACTGGCTCCTTCTGGAATGACTCCTTTGCCAGGCTCTCACTGACCTATGAACGACTCTTTGGTACCACAGTGACATTCAAGTTCATTCTGGCCAACCGCCTCTACCCAGTGTCCGCCCGGCACTGGTTTACCATGGAGCGCCTCGAAGTCCACAGCAATGGCTCCGTTGCCTACTTCAATGCTTCCCAGGTCACAGGGCCCAGCATCTACTCCTTCCACTGCGAGTATGTCAGCAGCCTGAGCAAGAAGGGCAGTCTCCTCGTGGCCCGCACGCAGCCCTCCCCCTGGCAGATGATGCTTCAGGACTTCCAGATCCAGGCTTTCAACGTGATGAGGGAGCAGTTCTCCTATGCCAGTGACTGTGCCAGCTTCTTCTCCCCCGGCATCTGGATGGGGCTGCTGACCTCCCTGTTCATGCTCTTCATCTTCACCTACGGCCTGCACATGATCCTCAGTCTCAAGACCATGGATCGCTTTGATGATCACAAGGGCCCCACCATTTCTTTGACCCAGATTGTCTGACCCTGTGCCAGTGGGGGGTTGAGGGTGGGACAGTGTCCGTGTTGTTGCTTTCCCACCCTGCAGCACACTGGACTGGAGCTTCCCTCTTCCTACCGCAGCATGAACCCCAAGCTCCCCTCAGCCCATCTTGCTCCCTCTTCAGCCTGCTGAGGAGCTTTCCTGGGCTGCCCCCATCTCTCCCAACAAGGTGTACATATTCTGCGTAGATGCTAGACCAACCAGCTTCCCAGGCTTAGTCGCTGTGAGGCGTAAGGGACATGAATTCTAGGGTCCCCTTTCTCCTTATTTATTCTTGTGTCTACATCATCCCTGGCTGTGGATAGTGTTTTTGTGTAGCAAATGCTCCCTCCTTAAGGTTATAGGGCTCCCTGAGTTTGGGGTGTGGAAGTTCTACTTAACTGTCCTGCTTGGCTGTCGTTATCGTTTTCTGGTGATGTTGTGCTAACAATAAGCAGTACACTGGGGTTTATTTCTGTGGCCTGAGAAGGAAGGTGGGCTGGGTGCGATCGTCGGCTGTCTGGCATGTTCCCACCGGAAGTGCCTGGCAGGAGCAGGGGGTGCTCGGTTGTTTCCTTCCTAATAAAGTAAACGAGGATCG + HJKKG'=JFK>KKEJJKJKIHGKHGIJKHKIIK>GIKHJDJKKKKGKKJKHJKKI?JKGKKKJKIGBAJKKKKHKKJIKGKJKK:BHIKKKFKGKKK?KKCKJHKIAFIKHKKKIKJHJK=JH@4JJHKKKKCKAIHKKKJKKJIHIEJIGKEK5KIKKKH9JA9KKKK7KIKJJIFDGKJDJKKFKJKKIJKJKFKBIKKKKKKKI>KKKFJKKFEJJ;JH2CCKGKIADKKKEKKKKK:JKJKKKJ>KKIKKKHDKKKKKKEKIKKK>HKAJKKKKCHIJKHJKJIIKJFKJJKKKKKGKK@HKKKKKICHIKKIKJKJKKKIJ@BKKKK4KHKKKKKGKKKHK=KJKIKKK>KKKKKFKKKKKKGKKGKK;JKKFHKKAJKKK6KKJEDKJ@KKKKKKIJJJAJKKKEJJJKKKJK7KHFJKDKJJBHJFBJJKJKK=KKKFKJKKKJKKCJEKKKKBJKJGKAK7BJFKCJKHKJKEJKIEKKKKJJHE@GJ;K@FGJKJKDGJ2I0KJIKKIICKKK.DJJHFKKJKKK4FHI>J3JJJ8IK@KGIKKKJKJKIK9IAG8KKJ@IGIK>JDJK&KKAGKIJHIKKKJHGIGB@D6KKBJ@JE9GHK:KJKKKD?CHKJK?JJKFKK=JKJJCKAGGHIK=IAKHJKIJIJAJG4FJIKKKHKIIEKFHGBCJCKK7HJBKJKKGJKHJGFKKKKKKEDJIFKIKGKKGJJKKKKDEKBJJKKKJKAHKGKIKKJIKJCEGJKKKJKKAKJKKKKGFJJKGIIIJKKJKKKGKKFHJJGGKJHHKKJFJHJF>KAAKCKKHKHDKII7BKG:KKKIK>JKEKKJIFJ/;IJJFFHHJHIKGK;AJJKKFJKKKKKFK8KKKJJKAHDKBFICJJ8HCCDEHJD;GJ=DAJK?JKIJDFKKE+IDC7AHGKJHJJ?JJDCKIJKKJK:JKKKAHHKKFBBHKIKKKIIIKGKJK8JCKJIIKJJGJHJIJ.GEHIDIKJKKCKIEKKK1GJICJJ=BKKCIGKIEJDJJFJKKKKKKKKAJKKKJIFIJGKJKDKKJJKKHKK3KKHKK?KKKJKKKKJKJKKKKKI2KKIKKJJIIFKAKJKKK@JKKKIKKIKKKJKKIKKDKK4KKHJIIIKJKKJKKHHKKAIKEKFKJKJKKJKKKKKKG-KIIKJIKKKIKKKKKKBDKKKIK@KKKKKKKKKFKKKK9KKKJKK8KKKCGHEKEK6JK=IIKJKEKIHKKKKKIKKKIKKIFKKKKKIFGKKKKK?K@KJJKIFJKCKGKKKK;JKFKKKKKJJHCKJKJKJJ1KKKKKKGHHKJKDKIIKIJKEKKKCKJIKKBKKJK=HJKJJKJKJKKJJKKIJGKJKKKKKEJJ7JK:KKJ?KJJKAKKKKJKHKKKKKKKK'GKJKKJAKCKKKHKJK3KKKK:KKI5IIKKJKJHKJJKKJ @rCer/1881/1591_57_CCS ATGGGGGCCCACTCCCTCCCGCCGTCGGCTGACGTGGAGGGCCGGAGGTGCCGGCTGCGGCGGCAGCGGCGGCGGAGGCTGCTGCCTGCGCCGAGGCTCGCGGGCGGCGGGCCCGGAAATGCACTCGGTGATGGAAAGAGAGCCACTATTCTGAAGAACACTTGGCCAAAGGGTCATTATCGTTATTGTGATGCTCTTTCTATGCTGGGGGAATATGACTGGGCCCTGCAAGCAAACATAAAAGCTCAAAAACTCTGTAAAAATGACCCTGAGGGAATCAAGGATCTAATTCAGCAGCATGTAAAGTTACAAAAACAAATAGAAGACCTACAAGGTCGAACAGCAAATAAGGATCCAATTAAAGCCTTTTACGAAAACAGGGCCTACACACCTAGGAATTTATCAGCACCTGTATTTGCAACTTCACTTAACTTTGTGGAGAAGGAAAGAGATTTCAGAAAAATTAATCACGAAATGGCCAACGGTGGTAATCAGAATCTAAAGGTGGTGGATGAGGTGTTGAAGGTAGATGATTGTGACTGTTATCCTGAATTTTCACCACCATCAATTGTAGTTCACCATTGACTTTACCAGCAGATTTGAAGAATATCTTGGAGAAACAGTTTTCTAAATCTTCCAGAGCTGCACACCAGGATTTTGCTAATATAATGAAAATGTTGAGAAGCTTAATTCAAGATGGCTATATGGCCTTATTGGAGCAGCGTTGCCGCAGTGCCGCACAGGCCTTTACAGAGTTGCTGAACGGTTTAGATCCTCAAAAAATAAAGCAATTGAACCTGGCCATGATTAACTATGTCTTGGTTGTCTATGGACTTGCCATTTCTCTCCTTGGAATAGGACAGCCTGAGGAATTATCTGAAGCTGAAAACCAGTTTAAGAGGATTATTGAACACTACCCCAATGAGGGACTTGACTGCTTGGCCTACTGTGGAATTGGAAAAGTATACTTGAAAAAAAACAGATTTCTAGAAGCTCTCAATCACTTTGAGAAAGCAAGAACCTTGATTTATCGTCTTCCTGGAGTGTTAACTTGGCCCACAAGTAATGTGATTATTGAAGAGTCTCAGCCACAAAAAATAAAGATGCTGTTAGAGAAATTTGTTGAAGAATGCAAGTTCCCTCCAGTGCCAGATGCCATTTGTTGCTATCAGAAGTGCCATGGATATTCTAAGATCCAGATATACATAACTGATCCAGACTTTAAGGGTTTTATACGCATCAGCTGTTGCCAGTACTGTAAAATAGAATTTCACATGAATTGCTGGAAGAAGTTAAAAAGTACAACCTTTAATGATAAAATTGACAAGGATTTTCTACAAGGAATATGTCTTACCCCTGACTGTGAAGGTGTCATTTCTAAGATTATCATCTTCAGCAGTGGTGGTCAAGTTAAATGTGAATTTGAACACAAGGTCATAAAAGAAAAGGTTCCTCCAAGACCTATTCTGAAACAGAAATGTTCTAGCCTAGAGAAACTAAGACTGAAAGAAGACAAAAAATTGAAGAGAAAGAT + KKKKKK5KKJJKKKKHJKK5IKKKIKKKJHJJKKIKHGKK=KHKKKKHJHKKKKJKKHKHKKIKKFKJJKKKKKJIKJ@9KJKKKJKKJKKKKKKGJJKKKIK9KKJKKKBKKEKKKKKKKKKKHFK>IKKJKKKK@KKKKKKJKKKJKHKKIKFJKKJKKKJKKKIKK>KKJJFKJ?JKKKK=KKGK7@JIJEJKKK?KFCKJKKKKJK7K;JJK?KKKKKEKK@KKKK9JIKK@KKKJKK9KIKKKKKK/KJKJKIKKKKADFDJKIJKKKKHKJJ?KJKHKKKIKAIJJKIKKDJKKI>FKFKDDCCI;HKJKKFBDKKKJKJ1IBBHKEHKG8KEIKHKKKKKIKJKKJKKCIJKKJKKGKHGKKKJKIKKIJKFHCJI8JFIGKDIIKFJDIH;KJJHKDJFHIIKK1JFFDGIIJJKKIIK@EJGHKKKK7K@JKJJIFJGAGKI @rCer/1882/1976_56_CCS ATGGGCGGATGAGGATTCTGTGGACTGGGATGAAGACCACCCTCCACCAATGGGGGAGGAATATTCCCAAATTCTTATAGCTCCAAGCTGTACAGATTCTTCAAATATATTGAGAATAGGGATGTTGCAAAAACAGTGTTAAAGGAACGGGGCCTGAAAAACATTCGCATTGGAATTGAAGGTTACCCTACCTGTAAAGAAAAAATTAAGAGAAGGCCTGGTGGCCGGTCTGAAGTCATCTATAATTACGTACAACGCCCCTTCATCCAGATGTCATGGGAAAAGGAAGAAGGAAGAGTCGCCATGTGGATTTCCAGTGTGTTCGAAGCAAATCCCTCACGAATCTGGTAGCTGCTGGAGATGATGTCTTGGAGGACCATGAAATATTAATGCATCACCCACCCCAAGTGGATGAACTTGACCGGCTAAATGCCCCACTTTCTCAGATGGCTTCTAACGACTTCAGGATTAGGGCCAGCTGTGGTCTACCCCTTGTGGGAGCCCATCTCACCTAAGATGCCTGCAGCCAGCCCTCCCTCATGATTTGTCTCACCCTGAGTAGGAATCATGCTTCTCCCCTATCCTTTCCTTTCTCCCATAATTAACATGTGTCCTTTCCAGTAAGTCTGTGCCTCTGGCAGGGGATGAAGAAGTACTCAAATTAGCTACCATCTTTGCAGCATCCCTGATAACTTGAAAAATTTGGGTCTGGTGCTGTTCACTGAGTCTTTGTGTAACGGCAAAAGCAGGAAAGGAAGTCAAGACTGTTGCCTTGTGTTTAGCAAAGCAGTCCTTATCCTTTATACTCTGTTCTTGGGTTTTGTTTTTGTTTTGTTTTATACCAGGCAAATTGCTTAGTAGCAAAGGGACCAAACTTAAAAGGTGACAATCTCTAACTTTTAAAAACAGGCACCAATCGGATGCTCATTAGAGGTTAATGAAGATGCCATTCTTGGTGGCCTCTGCACCCAAATTGCATCTGGAAAGAACTAGGGTCTCGTTCAGAATGTCCAAAAGGAAATTCCTAAGAGGTTAAATTCAGATTTGCTTCTCATTAACGCAGCAAACAATTCAAAACCACAGATTCTTTGGCAGGAAGGATAATGGAATAATAATGTGATGAGACCTTTTTAGCTTCAAGGTTTTGGAGTCTAAAAACAAATGGATGATTCATTTGGAATGAAACTCACAAGTAGAAGAACCTCCAAATCAGGCCAATTGGGTTATCCTGGCTTGGAATCTGGTGTGAAACCATAGGTCTTAACACTCTGGAGCAGCACATTGCTGTGGATGTGGCTAGGAGACCTTAGATATGGCTTAAAGGCTTTTAAGATGAGGACAGAAATTGCTCACAATTGCTCACTTTCTCAACAGAAAGACTTGTAAGAGTGCCAGCACGGGGTGTATGCAGTGAAGCTGGGTGGGAAGCATCCATCTGCACAGTCGCTGTCCTAGCAGGATTTTTCTCTTATCTTTTCATACCATGGGATTTTTGGATATCAGTGTATTTTGGTTCTTGAAATAGCCTAATAGCTGCTCACACATTGGGTAAGAAATTATACCAATGTCATCCCTAAAGGAAGGGTGAGTTGAATGGAAATTAAGCCCGGTCATTTTATTTGATCTATCAGCTCTATTATCAGTGCATGATCACCCAGATCACCCTTCTCAGCCCCCACAGTGCTGAACCATCTTCCTTCCTCTTCTCCATGGCTATTAAAGTACCGCTAAATTTAGAGTCCAGAGCCAGATAAAAGTATTTTGGGATTATCTCCCAGTTTGTGGTAGAAGCTGACTGGAATACAGGTTGAGTATCTCTTATCAAAATGCTTGGGACCAGAAAGGTTTCAGGTTTCACATTTTGGAACCTAACAGTTAAGTACCCGAAATCTGAAAGGCTTTTGAACATCATGTCGGCAC + 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@rCer/1883/25_1845_CCS ATGGGGCGCCGGGTCCTGCCCCAGAAGCTGCCGGCACATCCACGCCTGAAATGCGGCGCTCAGTCCTGGTCAGGAACCCAGGCCACAAAGGCCTGAGACCCGTTTATGAAGAGCTTGACTCTGATTCCGAGGACCTAGACCCAATCCTGAAGATCTGGACCCGGTTTCTGAAGACCCAGAGCCTGATCCTGAAGACCTCAACACTGTCCCGGAAGACGTGGACCCCAGCTATGAAGATCTGGAGCCCGTCTCGGAGGATCTGGACCCCGACGCCGAAGCTCCGGGCTCGGAACCCAAGATCCCGACCCCATGTCTTCGAGTTTCGACCTCGATCCAGATGTGATTGGCCCCGTACCCCTGATTCTCGATCCTAACAGCGACACCCTCAGCCCCGGCGATCCAAACGTGGACCCCATCTCCCCTGGCCTCACTGCCACCCCCCAGGTCTTGGCACCAGCCCCGCGGTGCTCCCCGCCCCCGCCAGCCCGCCCCGGCCCTTCTCCTGCCCGGATTGCGGCGAGCCTTCCGCCGCAGCTCCGGCTGAGCCAGCATCGCCGCACCCACAGCGGTGAGAAGCCGTACCGCTGCCCCGACTGCGGGAAGTCCTTCAGCCACGGTGCCACCCTGGCGCAGCACCGTGGCATCCACACCGGGGCGCGGCCATACCAGTGCGCGGCGTGCGGCAAGGCCTTCGGCTGGCGCTCCACGCTGCTGAAACATCGCAGCAGCCACAGCGGGGAGAAGCCGCACCACTGCCCGGTGTGTGGCAAGGCCTTCGGGCACGGCTCGCTCCTGGCGCAGCACCTGCGCACGCACGGCGGCCCGAGGCCCCACAAGTGCCCGGTGTGCGCCAAGGGCTTCGGTCAGGGCTCTGCGCTCCTCAAACACCTGCGCACGCACACGGGCGAGCGGCCCTACCCGTGTCCGCAGTGCGGCAAGGCCTTCGGGCAGAGCTCGGCGCTGCTGCAGCACCAGCGCACACACACGGCCGAACGCCCCTACCGCTGCCCCCACTGCGGCAAAGCCTTCGGGCAGAGCTCCAACTTGCAACACCACCTGCGCATCCACACGGGCGAGCGGCCCTACGCCTGCCCGCACTGCTCCAAGGCCTTCGGGCAGAGCTCAGCGCTGCTCCAGCACCTGCACGTGCATTCGGGCGAGCGTCCCTATCGCTGTCAGCTCTGCGGGAAGGCCTTTGGCCAGGCCTCCAGCCTCACCAAGCACAAACGGGTGCATGAGGGTGCAGCCGCTGCTGCAGCTGCCGCGGCTGCCGCAGCTGCAGCAGCGGCGGCCGGCCTGGGCCTAGGGCCTGGCCTAAGCCCTGCATCCATGATGAGGCCGGGGCAGGTCTCCCTCCTGGGTTCTGATGCTGTTTCTGTGCTCGGCTCTGGCTTGGGCCTCAGCTCTGGCACCAGCTCTGCCGTAGCTCTGACCCTGGCTCCGGGCCGGGCACTCTGCCGGATCCCAGCTCCAAACCCCTCCCCGCTCCAGATCCACCCCCAGCCTACTCCTGTGGAATCTTCTGACCCGAAGGCTGGGCACGACGCTGGTCCTGACCTTGTGCCCAGCCAGACCCTGATCCTGCGCCCAGCCCAGACCCTGATCCTGTGCCCAGCCCTGATCCAACCCTGTGTCCCACCCTGACCCCTGCTCTCCCACTGGTGACACTGTCAGCCCAGCCCTCCTACCGGCGAGAGTCCAGAGTGGGTACAGGAGCAAGGGGCACTGCTGGGGCCTGATGGCTGAAGGGGACTCGGGCATCCTCCGGGGCCTGGGGAAGTTGTGTGTTGTGCAGTTAGTAAAATCCTCCCACTGCCTCC 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@rCer/1884/0_1337_CCS ATGTTTGAGACCTTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCTGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTTGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACAC 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S'(&*-+(,,+-#(&(#&*')+&-+**.,1100/)''+,0,)(01*0,11010,+,'.//+0,+0&-)--...21111000+%1/,)/-/.*',2--1-1+/(+.1*1.0/11122/'+,0-.+%+-01/,011*(1111/-0&1.,',/0-,*-,10),11111.1*02--10*-+./,,*+2.1-/)1,-1/1-&.+0*0.++,,*,0*.-0*/1.+0010.,11++-1002-.120,--,-0-01-11'//.22,-0-01/0*--/,//2/+1,-/',-.010-)+*00/+/(#--/..,01-00.021'.0.0,--++2.,2--(*101..+/**,(--1',--/+110-1(,.01,-00-*-+-0210...,/-..21,)$,/211.-1*.,0)1-*,+-0-0./,.*('*&$'-,1,1-1*.-.,102.,1/*'&*.-10*-/,-+,-+-)-111),//2216434,403561665105165513//364351.01130'3)'22244/132*4.4-123113.,72*6,82.512/.+/2)18655640%55,8969::94333244384:4958446868:.7601001101.410-112154313-1168/6921#&+/-*'/074632546:586'5474387;67:5:2675::;572056;/45444279068990/-235:9660717255878845321*/2/'23353431.1,13143133;7:9:/(5496:7.3834::79991:7498.-0276418260:8574:170-=5%9882474;978;59:6<=:?9;8>==+=946477838<9:0=9>;1#*+<&8)'$59))79:;;:42'44/6&79<94(:8=9;89<8>43=<<=4;:636$;:*<;:;563>==?=;>>-;=<6+8=;5==984464655DCAE5DD:GD?<;/B98AD;CE@IAE;F@<C:AF?8%6BC@>AHI9AHE@A.?;;<6>8FFG?HB=DC<9H8B0?F;DHBB6?EC>@HEFBD?C;E5E>IB?5:<6;AC7@8D?BE8DBA>=IDGD;=>=A>%7):;?:DHD>8EB>-DGC/>8C9B3@F4E?5%?;EE<6CC;7AEB&01C>9388?==;7=C?:0>BEH@;BB><=C;7IGB=@CGEGC;:E:@>D;A=<@19=3;0:@B=FCDB.BDFA>=@>BBC;BD8=A;BIDA?DFACBA?BE6?6DBCC@=%D:BF1IC;>BEBB>@>:C9CHG@;@@CAEA;>DEB=;+9F=HDCG?@4CAFFBE>>F=CC:C=@@DFG.C@E>@6BB)?BE<@7BD@F>E@E<;;BC9B?BB8=FC<@9?@:8989?:9/>?5DEGCG3EC9ED1G?;58&936)16DA:9B=@BE3?8BC@GFDGEF=:DE?3;HB9;6AEACCGBCEC/>@97;>?E>>?GFGI?ACDF;E@:=9C-B?DC?<(0<6:GC>:==>C?C7?<=:?ADEC8A:<@;59+7;?.@69>7=90.17589=D<9<*<67=:)AC=8;B:F?>C>ADCF:FA<4BG/F=>F3A=?,D;==A;;<>3DE<83)3.6(=9>?DDFC?5AA3EC=:AD?@E;7?@<.GD;<@BCE6BCDH?,AA2JBHBAB?@@BA:C4>8B?HIFGHD@A.9:BB@AG$CFD9??:8;<(8?<8@E3F=2<@:<685?)?;4C:@E<;18<4<=BAD@B3*7C?8GD=:96:5*;>B@/>?;CB6??2BEEBC=:?;B9@?0;>6;@3A@DAD?9A>FBC:0852/B:>GC6A9@:;6:?A?@&DDBBD;;7A=@<@9@F>@?9BC8?F>B?9:>->E5<><;=D87>;G7@DCA>;92=4EC59DCB5AA<<1<98)?97;3=9GF@8?=<1B?CEA-:52>>8?827E;BDD=DAAD?DI;1G:EA9>;A;22EFGD<=C;EAA<>G;AAA>F:6=78D8>>D@0@8D>H6<51,@E@=>2DB0GE:>E=<$?>31);6=6B.:BIE@HE4F89HDD>C:A9;<6D?@B?C=>3;=><@A48@@@@@7;%GC?=EEH?;FA7J@>AFDGAAA<56==6>AEA?4=8<872C;A.=>FCDEDJEB<9CFEDBIFG@I@BC@A<79>3;(6GCG44AHFD@??9.?E:3==4<29A?B@3<:?CE<;45<409==2)==C=>F;9:57;@B?>79::7;497;5)<:CA;:8:><5?=;@>8:?7C7A7C298EB9359071<5>>92=<73,CE>CBB:=@0A@E8:/;4<6?5A><:;6<05?>A===9;A724A=A>?36:8==75:6<:?E3A?:97A6=:AB=:+/059::&2;:73>2<@0B>ED?CA>4=C>@=A;3B>A=FFB>2;06<(28B?=??@%D9A6;>;F@C;74955:>:=794( @rCer/1891/27_1946_CCS GAGAGCGGCGCCGGCCTCGGAGGCTGAGGAAAGCAGGAGGAGGTGGTGGCGGCGGAAGATGCTGCTCTTTGGCGTAAATTGCAATCGATTAGGATCGTTTCTCAAAATCAAGTTAGAAGTGAGAGTTCAGATAAGTGAGGCCGCCATTGCTGCTTTGAACACCTCAGAAGGGAGAATGGATTTATCAGGAGTGAAAAAGAAGAGCTTGCTAGGAGTCAAAGAAAATAATAAAAGTCCAGCACTAGGGCTCCTTCACCCACCAAACGCAAGGACCGCTCAGATGAGAAGTCCAAGGATCGCTCAAAAGATAAAGGGGCCACCAAGGAGTCAAGTGAGAAGGATCGCGGCAGGGACAAACCCGAAAGAGGCGCAGTGCTTCCAGTGGTAGCAGCAGTACCAGATCTCGGTCCAGCTCGACTTCCAGCTCAGGCTCCAGCACCAGCACTGGCTCAAGCAGTGGCTCCAGCTCTTCCTCAGCATCCAGCCGCTCAGGAAGCTCCAGCACCTCCCGCAGCTCCAGCTCCAGCAGCTCTTCCGGCTCTCCAAGTCCTTCTCGGCGCAGACACGACAACAGGAGGCGCTCCCGCTCCAAATCCAAACACCTAAAAGAGATGAAAAGGAGAGGAAAAGGCGGAGCCCATCTCCTAAGCCCACCAAAGTGCATATTGGGAGACTCACCAGGAATGTGACAAAGGATCACATCATGGAGATATTTTCCACCTATGGGAAAATTAAAATGATTGACATGCCCGTGGAAAGGATGCATCCCCATCTGTCCAAAGGCTATGCATACGTAGAGTTTGAGAATCCAGATGAAGCTGAGAAGGCGCTGAAGCACATGGATGGAGGACAAATCGATGGCCAGGAGATCACTGCCACTGCCGTGCTGGCCCCCTGGCCTAGGCCACCACCCAGGAGATTTAGCCCTCCAGGAGAATGTTGCCACCACCGCCCATGTGGCGCAGGTCTCCGCCACGGATGAGGAGAAGGTCCCGCTCTCCGAGGCGCAGGTCCCTGTGCGCCGGAGATCACGCTCCCGGGACGCCGCCGCCACAGGAGCCGCTCCAGCTCCAACTCCTCCGATAAACAGGCCACTGAAGCTCTCGCCCCTGTAACTTATACCCCACCCAGCTCAGTTTTGTCACTTTTCTAGCCAAAGGAAGATCAGTAGGAAAGCAAAACCCTTCACTCGGGCAGAATTTGCAGGCAGCAGTCAGCACCCCTCTGCCGGCCGGGCTCTGGCTGCAGAAGTGCTGTTGGTTTGGGTGTTGTGTGCCTGTCAAGATTCCCTCCGGTTTTGTGGCTAGGAAGCTCGCCCGCTTCCAGTTTCTAAGAGTCAGTTCAGTGGCAGGGCCACCAGGGACAGGTGAGGCTCTGGGGGATGGTGTGACCCTGCCTGCCTGGGAGCACACTTTTCCCTTCCCTAGTTACCTGAGATGGTTGCCAGACTGTGCCCTTGCTGTTGCTGGCGGTGTCCTTTTGGAAAGGGAGCCGTCCCGAGCTTTAGTGCAGCTGCCAACCTGTTAGCCTCGGCCTCTTGAGGCCTCTTCCAACTTCAAGGGTCACACACCCCAAAGATCCTCTCACCTATGGTAATTGCTGTGCATGGTTCTGTCTGTCCGTGCACCCATGCACACACCCCACCCCACCACCCTACTCTGAAATTGGCGAGTGAGAGCCAGCTGTGCGGGATCATCATGCAGCCATGGTTGTGCCTGCCTTCGTGGTGGTCTTTCAGGTTATCTTGGCAACATGTACATTGCTTTTTTTTTTTTTTGCTTTTTTGCTTTTATTGTACAGTCAGTACTATAAAAATTTCTCTTTGAGTTTTATACCTTTGTAGCATTTAGATGACATTGTGTTTGTACTTTGTTGTGTAGAGTGGAAGAATTGTGTTGAATAAACCCAAGATTGGAATG + ?+3-<;=?::3=45/>560:61>:2767>6?>55(%0+2=6(42(89<;>:>6);5<;57=99::<:8=;:?<<;7:;<==93>=>:;.6-*:5.:>,<7;;;)8>:7>3;:8?<:;=;>>==<97?<361+/8==>;::.:385<+:8:;9816:858<4475;9;48-;B;@>A?5?A:>?@:=;6=0>@B>A?B>A7=??BA>CBC@@=B9<=8B>A>8<4%??;4<;?>=AAB9:AA:?>4?;@A?1>AB;C4BA>AA=A6@84@9205<@<8A.=8B7A8C7@9@;:>ABA?5CABBA98@6=@44B@>A%;<-;;7/=??3=A->4@B>A?;C/;>77=?86>;:<>189=2=9.82+:71<:5BAC=3AAB88C';9@=?A<4@66:@8=6@,?=9=;>?6B2?B;B@B6A:&=<;.93;9=6>A3=7@=6>B@9A66:C??BCB==1>99C;A?==7@59?=C@>A6?B@B9>;@&;6?548;;@>>>966:<10=0@>=:B:'9>;@@*59@>?;>&@>?:@:C9*68=84BAB;AB=8917ACB@BAB=A*?BA:;A2@;>1AA?>(87C?1C?8CC93A8CCB=>9-:85?>CC<<>;?@6;BB/B8B>;@A276?C>C<=3<6;?;>A4C89*2537AA=C.:B6A>6C@B;?5BB<6;>>CBB>?;:-8;=::A5C?>CB7=?;;5ACAA@>:=?:>.>A39<::>:>A8==@A@=BB:<51;:=C@@7=@5@?CB@B299&>BCC@B30;>C2<;6?@B8?AAB<@:>>A??=8B'7>@==.;8?<&::%><9>94><9A?268AA9$??.4=75:46*=<%?2(;31:0-7A8.AF?E=<>?08@;=>@C)86@=C?<=69A;EBF6?9:A;2>D,>>ABB>B?&67=6?:;;@>A<6)<:+6A=FB5CC5E?7?<;<)=AC0@=<<6>CA;@2=<@>A?7-=;>;3<8BE2C2=AFEBFFC@GBGFC@DBG0EG@C2AAA=><@=??D/>DB<)C><2@C6BEBAFF==FD>>BE7B>C;=>BC2=EFBD@=<5>&>57?3:>=F0D:D'A>A=A*>;@<:?DC<==6ABBE<:@;?/<)<88>@@F+CC?@B9=5<>;<*7><6A:=A?>6<@69B1A?FE>C@@A:6ABDF@?5A-><=@+ACAB2EE:8><9=B>7C:?EC1@D@>E>5C9;EA=4D;<69)CC:?E?@E?C?DC$C<3>=F@9@(>F?29;B?6>A;A(>CB6GADF:F9BB:E?CDDA@=C6=6=*;69@B?>;FD@1;EBCFBG?AC;ECDFEE=?=$B@::AEDFF@2BBC@==?==6?@AA=C@BDCF>>?=AABE;G?==:@@4E7B=DE;@E@;AB<#:;>=::;==?@@?><+>@@>:=C<@FBD?;?7A@:;>CB:@A<:8=':@D@9DBBCE;CCCB:/@?:90A=.D<5C?1@9B=1:=;B9@6@=>?:?AE=B<996>;BA7=C5C<:A@EDEF>A9?AE9ED3GG)@@>E9>,7 @rCer/1892/0_1574_CCS GTGACATAAAGATCGGCCAAGATGCCATGAATGTGCAGCCCCCAGAGGGCCGGAGCCGAGATGGCCTGCTAACTGTGAACCTACGGGAAGGCGGCCGCCTGCACCTCTGTGCGGAGACCAGGGATGATGCCCTAGCTGGAAGACAGCGCTGCTGGAGGCGAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCCTCTGGCCATGGCATGCTTGCGGGAGCCGCCACTGGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCTGCTGGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTTCTTCCTCCTGGACCCCGCTCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTCCCCCACTCCCTACCCTCACTCCCACATGGGAAGAAGCTGTCATCCCAGGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCCAGACACCCCCAAATCTGTTATAGGCATTTATGGATATATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGGCTTCGAGTTCCGTAGACACGACATGAATCGGGCTCTCTGCTCTCTCGTCAGGGAGCTCGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGCAGAGAGCAAGGCAGGTAGGCTGGAAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGGAATTAAATGGGAGTTCATCTGGCCTGGGGTGGAGGCCAGGATCAGACCATGGTGGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGGAGATGTGAACGTTCCCTGGAGGGAAGTTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATATGTCCATACCCAAAACACCCCTGCCCACAACCAGCTTCCTGGCTGGTACCCATGATAATAATTGAGCTGAACCTTGGGGCCCCTCGTTGGGGAACAGGTGAGTTCTATTTGAGACTTCTAGCCCCAGGAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCCTTTTGTAGCTGTGACTGTCACCCTCTCAGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACTTTACACCAGCCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCTTTGGTCCCTTCCAGTCTCTTCCCCCTTTCTATCCAATCACCAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTGGCTT + S(&'&$&&*,+)),)-.1&*%"$0-0(')"%,.-0/).$-,)/,'+/62)6.1.//14225*04,20460(.-,0/412//0/5*42.74:7(607858:7734*3968114.8-78971*/..33260(133&3'%12281/79:143594(1)526933897213'4.4-36561',,%0491939424722&60324,-&1955/54'/12#.&351587411/3/#0//5128450454169666456:992642:8086838367,2+5:221(316)453..-1425643742841,.36/27./,/-9569824-.5438:99825904,2$844477,576.94/93;:5;76:0:383,8/36375;::::8/1/211(1201$-$))+,1(36::29/6:92::80;69984241/*1,06-,.43/22240)../*0//,&/.0+.3+66/778;6'114323330-.+/1./00//+53/2.*00,/)-4.0.121./02.00.-,+/.3101200&0&)*,&-+*,.-.12$6527*,-+43.,',,,42/3'25../,)1/27.'-/20623/.1515)97:88;=63568722012141*197977717:>6=?:678.(86/;'4249;/,=:=46<5'+=928-<+*430%3:===8<0>:/299/;;%689=83;84=<=::(33.;;72;<7:84;<>5;878>:69::467<7:5<<:?674;:;48<07=849=8<;=1350<864967<91<5:5$+'(05,2/384404/-4)752.90+77+3259-869644465*5.<39>8:14>4==86/6.<=:98/8,.;===554;6:63.,04,25/329327<+5;5/964647-38177:=7;006<;;,91>3;>3:77798-79<208/19;>2853'0.6163?>69,;;9*+5297?<282><6:=6<<:5%8;5:3648?6844:1=8.<3;7499,2-<2646:3=)982<:;=69:'87699<52795:=7=<:;?>18959842053.,14=034/-526<.)*786341&112)-87,21(0135;/-,+1/(,12..&/2-/4356093;5?==<6=0:62:3:1>:91>9909761:867,77;;44:,8/508&83*,976888;<49>=579<878;8>2?><:9?;54584+444-<&<;:89:0=?>>>:>6<9<<1;571774646,:8/*3;*87.5/8:97171<56+#2698769>389/9<9>965'7/72<23$8*;0.=9997622777634<759,5<9:9878<<5$53<557593:'7992:.995/993*684898?>:&786//2777567/-.7<41082:0;9;881>6>9719388179:1'=9;/53458(59)25/80457331-<:67):9:75;$,-5003267:=>92=;6=99-;4-3.:>5*/5*/9238*;5*692<6+;804-&36823*98::8$752'89=8386=4-71/-70483+37376956.22727624+..('%,/60; @rCer/1893/1440_58_CCS ATGGGGACACCACGTGGGGTTTGCTATCGGAGCTGAGTCTCCGGCCGGCGTCCAATTTGAGTCTAGGTTGGAGTTGGAACCGTGGAGATGCGGAAGGAAACCCCGCCCCCCTAGTGCCCCCGGCGGCCCGGGAGTGGAATCTTCCCCTAATGCGCCCGCCTGCATGGAACGACAGTTGGAGGCTGCGCGGTACCGGTCCGATGGGGCGCTTCTCCTCGGGGCCTCCAGCCTGAGTGGCCGCTGCTGGGCCGGCTCCCTCTGGCTTTTTAAGGACCCTTGTGCCGCCCCAACGAAGGCTTCTGCTCCGCTGGAGTCCAAACGGAGGCTGGAGTGGCTGACCTCACTTGGGTTGGAGAGAGAGGTATTCTGGTGGCCTCTGATTCAGGTGCTGTTGAATTGTGGAACTAGATGAGAATGAAACACTTATTGTCAGCAAGTTCTGCAAGTATGAGCATGATGACATTGTGTCTACAGTCTGTGTCCTGAGCTCTGGCACACAAGCTGTCAGTGGTAGCAAAGACTTCTGCATCAAGGTTTGGGACCTTGCTCAGCAGGTGGTACTGAATTCATACCGAGCTCATGCTGCACAGGTCACTTGTGTTGCTGCCTCTCCTCACAAGGACTCTGTGTTTCTTTCATGCAGCGAGGACAACAGAATTTTACTCTGGGATACCCGCTGTCCCAAGCCAGCATCACAGATTGGCTGCAGTGCGCCTGGCTACCTTCCTACCTCACTGGCTTGGCATCCTCAGCAAAGTGAAGTCTTTGTCTTTGGTGATGAGAATGGGACAGTCTCCTTGTGGATACCAAGAGTACAAGCTGTGTCCTGAGCTCAGCTGTACATTCCCAGTGTGTCACTGGGCTGGTGTTCTCCCCACACAGTGTTCCCTTCCTGGCCTCTCTCAGTGAAGACTGCTCACTTGCTGTGCTGGACTCAAGCCTTTCTGAGGTGTTTAGAAGCCGAGCCCACAGAGACTTTGTGAGAGATGCGACTTGGTCCCCGCTCAATCACTCCCTGCTTACCACAGTGGGCTGGGACCATCAGGTCGTCCACCACATCGTGCCCACAGAACCTCTCCCAGCCCCTGGACCTGCGAGTGTTACTGAGTAGATTGGATTTAAGACACAAAGCAAGTCCCCATGAGCGTCCACTTCTTTGCCCTACCCTCTCAGCTTGTGAGACAACACAGGAGCCTTCTGTAGTATGTTGATATGCTAGATCTGTGCCATTAAAAGGCATCGTCCTCAGCCTGAGGAGGCTGAATTCTGGGTTCCTGTAGTCACAGGAGGAAAAGCTTTCTTAAAAATGGACATGTATGTGCGTGTGACTGTGTGTGTAGATTTATAGTTTTTGGTAGTGGCAGGAATAAAACAATCCATCC + KKKKK9KKKKKKKKKKKK+KKAKKKKKKKKKKKKKKKKKKK=K>KAKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKIKKK6KKKKKK:KKKKKKKKK*KGKKKKK8KK-KKKKKKKKIKKKKK(KKKKKKKKK5KKEKKKKKKGKKKKKKKKKKKKKK4KKKKKKKKKKKIKKKKKKKKKKKBKKKKKDKKJKKKKK%KEKKIKKKHKKKJKK8KKKKKKKKKKDKFKAGJKK1KKKKJKKKKK3KKKKKKKGKKKKKKKKKKJKKKKKKKKKKKIKKJKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK&KKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKJKKKK?KKJKKKKKKKKKK=KKKK>KKJKK;KKKKJKKKKKKJKKJKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKIKFKKKKHKKKKK3K?KKKKKKKKKKIKKKKKKKJKKBKKKJKKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKK2KKKKKHKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKCKKKKKK@KKGKKKKKKKKKKKKKKKKKKKJKKKKKJKKKKKIKHKKKKKKKKKKKK4KKKKKJKK&KKKKKFKKKKKKIKKKKJKKKJKKKKKKKHKKKKKKJJKKKKKJKKKKKK&KKKKKKKKKKJKK3HKKKKKKKKKKKJ8KGDKKKKKKHKK8KAK7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKJKK;KKKKKKKKIKKKK?KKKCKKKKKKKK:KKJIKKKKKKEKKKKKKKJKIKKKKKKKKKKKK;KKKKKJKKJKKKKBKKKKKKKKKKKKKKK:KKKKDKKFDKKKKKKKKKKIKKKKKKKKKKKKK6KKKKKHKKKKKKK9KKKKK-KKFKKKKKKKIJJHK5KBKJKKKKKKKHKKKKKBKKKKKJKKKKKKKJGKKKK#KKKKKKKKKKKKKHKKKIKKK5KKKK'KKIKKKKKKKIKKKKKKKKKKKKHKDKJKJKGKKKKKKKKK=KJHKKCKKKKKKKJKKKK)KKFKKK:K,HKKKJFK'KKKKK>KKKK(KKKKKKKIKKKKKK-KIKBKKCKKKKKKKK%KKJKKKJJKKKJKKKKKKK@KKEKJKKKKKKKKKKKHIIGKKKKKKKKKKKKKKKKIHJKKKKKKGKJKKKKK8KKKFKKKKKKFKKIJKIKIK2 @rCer/1894/25_1975_CCS ATGGGGGAGTCTGGGTTGGACTGGCGGCCGTGGAGTTTGTGACACACGAGGTGACACCCTCGAGTCACTTCCCTTCCACTCCAGCTGGAGCGCCTGCCTGGCTTTGGGTTCGTTCTGCAGCCTTCGTCCCGCTCCTAGCCTCAGGGCCGGACTCCAGCGCAGAGCCCAGCCCAGCGCAGCCTGCCAGCAGCCGCCAGCAGCCCAGCACGGCAGGAAACCCGGCCAGAGCTCCCCAGCAGCCCGAGTCATGAACACCGAAATGTATCAGACCCCCATGGAGGTGGCGGTCTATCAGCTGCACAATTTCTCCATCTCCTTCTTCTCTTCCCTGCTTGGAGGGATGTGGTTTCCGTTAAGCTGGACAACAGTGCCTCCGGAGCCAGCGTGGTGGCCATAGACAACAAGATCGAACAGGCCATGGATCTGGTGAAGAATCATCTGATGTATGCTGTGAGAGAGGAGGTGGAGATCCTGAAGGAGCAGATCCGAGAGCTGGTGGAGAAGAACCCCAGCTAGAGCGTGAGAACACCCTGTTGAAGACCCTGGCAAGCCCAGAGCAGCTGGAGAAGTTCCAGTCCTGTCTGAGCCCTGAAGAGCCAGCTCCCGAATCCCCACAAGTGCCCGAGGCTCCTGGTGGTTCTGCGGTGTAAGTGGCTCTGTCCTCAGGGTGGGCAGAGCCACTAAACTTGTTTTTACCTAGTTCTTTCCAGTTTGTTTTTGGCTCCCAAGCGTCATCTCACGAGGAGAACTTTACACCTAGCATAGCTGGTGCCAGAGATGTCCTAAGGACATGGCCACCTGGGTCCACTCCAGTGACAGACCCCCTGACAAGAGCAGGTCTCTGGAGGCTGAGTTGCATGGGGCCTAGTAACACCAAGCCAGTGAGCCTCTAATGCTACTGCGCCCTGGGGGCTCCCAGGGCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTAGTTTGAGGTGTGACACCAGTTTGCTCCAGAAAGTTTAAGGGGTCTGTTTCTCATTTCCATGGACATCTTCAGCAGCTTCACCTGACAATGACTGTTCCTATGAAGAAGCCACTTGTTTTAAGCAGAGACAACCTCTCTCTTCTCCCCTGCTTCATGAAGGCAGGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTTTCTATATAGCCATAAATGCGTATATATACCCATAGGGCTAGATCTGTATCTTAGTGTAGCGATGTATACATACACACATCCACCTACATGTTGAAGGCCTAACCAGCCTTGGGAATATTGACTGGTCCCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTACCAAGTTGACCCAGTTTGTCCTTTAGGTTAAGTAAGACTCGAGAGTAAAGGCAAGGAGAGGGGCCAGGCTCTGAATGCGGCCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTCCACTGAAACGTGAAGTCCTCTTTTGAATGCCAAACCCACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTTTGTTTTGTTTTGTTTTGTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAACAGAAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGGGAATGGCTTTGATCCAATGGAGCCTGGGAGGTGTGCCCAGAAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTTCCACTTTTTTGACACCTTATCCTGATGTATGGTTCCAGGATTTGGATTTTGATTTTTCAAATGTAGCTTGAAATTTCAATAAACTTTGCTCTGTTTTT + 04(5555244452611506/55/6425+2515611/64620/1*..,0-+335255#420-2055234253662612,..13-3/&',$)**)-*.)33-**+44+302613'3046662+1232/2,241/)2600.4144)/55+016554461446214//46665)5/+((.4353555*..3461,20$431045336502334644*0+2432646562510212566512.326665)21064*324564-35134-/0555'303211.25355544461/33666621-445/41665536040456'44.5422.2.1653505466-34&3/412)65.3245&0,,-36./*10--,*+//)10503/3),,//.2)0635230452-52,444110'34146162/0430/**325.5416/.014)3401-0256365/42122+3425516-0-226550./6446504/+35653642)53451126/-00#64241.+2325443.0.44356553.3,,4*2036++2134436665./004114601155+505)//361*0/4422.445656464166043062326446653124(/-)2.34/3(./2526.14'3+1//411201551'41333463523'-353.46/-13006140-554-4'&1-42.3555.-11*3+,335/56.*4654/3*($/.*4421,60124353513604'..'1.)-4455052135/,,)-'0*(#,13.02506123/4132..4)221-/'4111645,40.3/426001-22631+20'/()112)2325/426012/+335464365*551361166156606+4346)*411+1423./121421-%+22.56.#210-,-).2/06/13*,34316112*/23344530+0+-33/-/.02*21*/214551+1222055503.)$./,14465//443'4524&321,041,31.11..452235164-443-5565.44036636664%0/+.0/0/0'30632.4251(51,3)3001+05626/,*/32//-534213875573*0755154/657(17;2:08)21669.7.16+)88969:94:9-42::;96728-7.798:3;:94;6;543-2.944,13333,44.:92130/3.3+4678526475431/62556;;298468.4:14.635/865'-(2-,..1409897'198;:::32*99645144363:9;55+999694+462357637:6,04::13653378783468:/7039726:04433271-5.251661/2(6-45752-.-3003%20965:7;024426(5306'36;5268.95%52030578954,97;:85;8&401758::573264.'-215946905015;;78%1759282/9819-6365+4640228/24+3/-49.:89;97:12$15149417435985:596.62:-85:886967;5::854687;59:5;:2:9775322,.01338'50/6383982,798/99888;24.1(741>=::?>:?:67=::83:793>;>4<36474:5==5*:;9825398776/28;?8==7/9436078:=>=:6?=?9):>70#;:7-:<;:5435;96939:>69:=60><20;:?>699>=9:49379?989;;5<=>>825/923-;74678>:4?398:?=>?<6>59<86;4:5.8;:9>6&5/521/88;4??624>=,68=531-747<<68=:;4;78<9;<:===:==;/==7<5<';<===>==74;5901)07:6/7478=?:;=?:2;4::577>3:=>:3.9=>>86===>84<>7968??:??94599>>=3;8=:>=<<7>;;> @rCer/1895/25_2201_CCS ATGGGGGGCGTCAGACAGCCCTGAGCAGGGCCCCATTGCCCCACCCCCGAGGAAGGCGAGGGGGGGTGGCAGGGGCTGCGGAAAGGGGCTGGGCTGGGTTGGGCTGTCTGCAGCTCTAGTCCAGGAGGCTGAGACTTCGAGAGGGACTTAGAGAAGGCAGACGCATCCCGAACTCGCTGGAGGACAAGGCTCAGCTCTTGCAGGCCAAATTGAGACATGTCTGACACAAGCGAGAGTGGTGCGGGTCTAACTAGCTTCCAGGCTGAAGCTTCAGAAAAGGACAGTAGCTCGATGATGCAGACTCTATTGACAGTGACCCAGAATGTGGAGGTCCCAGAGACACCGAAGGCCTCAAAGGCACCGGAGGTCTCAGAGGATGTGAAGGTCTCAAAAACCTCTGGGGTCCCAAAGGCCACAGAGGTCTCAAAGACCCCAGAGGCTCAGGAGGCACCTGCCACCCAGGCCTCATCTACTACTCAGCTGACTGATACCCAGGTTCTGGCAGCTGAAAACAAGAGTCTAGCAGCTGACACCAAGAAACAGAATGCTGACCCGCAGGCTGTGACAATGCCTGCCACCGAGACCAAAAAGGTCAGCTGTGTGGCTGATACGAAGGTCAATACTAAGGCCCAGGAGACTGAGGCTGCTGCCTCTCAGGCCCCAGCAGATGAACCTGAGCCTGAGAGTGCAGCTGCCCAGTCTCAGGAGAATCAGGATACTCGGCCCAAGGTCAAAGCCAAGAAAGCCCGAAAGGTGAAGCATCTGGATGGGGAAGAGGATGGCAGCAGTGATCAGAGTCAGGCTTCTGGAACCACAGGTGGCCGAAGGGTCTCAAAGGCCCTAATGGCCTCAATGGCCCGCAGGGCTTCAAGGGGTCCCATAGCTTTTTGGGCCCGCAGGGCATCAAGGACTCGGTTGGCTGCTTGGGCCCGGAGAGCCTTGCTCTCCCTGAGATCACCTAAAGCCCGTAGGGGCAAGGCTCGCCGTAGAGCTGCCAAGCTCCAGTCATCCCAAGAGCCTGAAGCACCACCACCTCGGGATGTGGCCCTTTTGCAAGGGAGGGCAAATGATTTGGTGAAGTACCTTTTGGCTAAAGACCAGACGAAGATTCCCATCAAGCGCTCAGACATGCTGAAGGACATCATCAAAGAATACACTGATGTGTACCCTGAAATCATTGAACGAGCAGGCTATTCCTTGGAGAAGGTATTTGGATTCAATTGAAGGAAATTGATAAGAATGACCACTTGTACATTCTTCTCAGCACCTTGGAGCCCACTGATGCGGGCATACTGGGAACGACTAAGGACTCACCCAAGCTGGGTCTGCTCATGGTGCTTCTTAGCATCATCTTCATGAATGGAAATCGGTCCAGTGAGGCTGTCATCTGGGAGGTGCTGCGCAAGTTGGGGCTGCGCCCTGGGATACATCATTCACTCTTTGGGGACGTGAAGAAACTCATCACTGATGAGTTTGTGAAGCAGAAGTACCTGGACTATGCCAGAGTCCCCAATAGCAATCCCCCTGAATATGAGTTCTTCTGGGGCCTGCGCTCTTACTATGAGACCAGCAAGATGAAAGTCCTCAAGTTTGCCTGCAAGGTACAAAAGAAGGATCCCAAGGAATGGGCAGCTCAGTACCGAGAGGCGATGGAAGCGGATTTGAAGGCTGCAGCTGAGGCTGCAGCTGAAGCCAAGGCGAGGGCCGAGATTAGAGCTCGAATGGGCATTGGGCTTGGCTCGGAGAATGCTGCCGGCCCTGCAACTGGGATGAAGCTGATATTGGACCCTGGGCCAAAGCCCGGATCCAGGCGGGAGCAGAAGCTAAAGCCAAAGCCCAAGAGAGTGGCAGTGCCAGCACCGGTGCCAGTACCAGTACCAATAACAGTGCCAGTGCCAGCGCCAGCACCAGTGGTGGCTTCAGTGCTGGTGCCAGCCTGACCGCCACTCTCACATTTGGGCTCTTCGCTGGCCTTGGTGGAGCTGGTGCCAGCACCAGTGGCAGCTCTGGTGCCTGTGGTTTCTCCTACAAGTGAGATTTCAGATATTGTTAATCCTGCCAGTCTTTCTCTTCAAGCCAGGGTGCATCCTCAGAAACCTACTCAACACAGCACTCTAGGCAGCCACTATCAATCAATTGAAGTTGACACTCTGCATTAAATCTATTTGCCATTTCT + JJJHHIH+JDH>$BBIHAB;G8J;JJII0KKKKIKHKJGJBKJGJJC?BJHCCFIHGJ8JFIHKIIJKHF=IKKEBAFFIJ1HGIFKKKE=KJJJKJHGG/EKGJGKGJKGKJEKD?HJ@IJJDDI=KJDK@IGKKKCKK7KKHFKIKJIKGJJJ?BECHIJIJJGKJKKGJJ?KKKKEJJFE:DFKJ:KJ?KH:CKGKHKCKKIG<$IGHI=KFKKKJIICF>>BD:GII3IF9KAJIJE@D@KH8HKIKBGCIJ?EDKKJDEDI?JH@FD=IHKBD8GFD;IBII;HGDHIJIK3FHEKFJKHKFIDJJK:IJKIDHCJKJGH>EKGFKJ=H=KKKG:KJFCKHI0KKKK>KF9JIIKECHGCGFGBIAI>FKKHKGIDCJKKJBG7KK8IIH@H*HHHIKIFJDIJ8JGBJK=J,GAB9KJIKKIBEH2ECCKJKHKJJJHJDKKKKKKH>KKJIIKIIHKGAFKFEHGHKIGJEJGIAH>E+72?BEIHFKIKEK@BBJ?7DH5IKKJKKKKJIGFG6CCGGH:KIDICKFIJH:CIKJGKJJIK=HGFBIKAKGKJKCICKJJED@J8$HFKKJ0IBJHEJGK2EI>GGB@/GDCKHICHJ>G?FDDDIKDK>4DBFEBHCH>D@(JHFHEHAI1D:F;B;HGAIAH1FCEBI:FI8H3BDE@GF9GFBBI=>HHJIHF@F1DGECEI?IFIBEE@ABEEBGGD=IGGIIIHHID8B=>I?C?3+AC6<<:2CDID=GAD=>>ADG@EF'@@>ACG5B:BCGC<=39;:9=DGE?GCA1>CEF7C-EBF=CGCF?DEEAB2ECF@CEAA?AD9E?F?EDCC@CF?B>?BCB==AEBBF>7@>3::CF@AC@@:F?E:B>E:A>CDE<;<7BFF2D?<7A??.BCE?@7A=;=@,A@-C:3C>5AC<:@>?BA@B@B6?AAG?B6DBAEA?ECGEDCD;A@DG@BE:DAFDE9B2@?C8D7??=CE7GDEAE?=;9DC=:>@DDCFFGHEEHB6HJJJHI>JJEH;G>;JJFJKEGJEE@7CEADBJ<>>4FDD?DE89DIJG4A>7HDHJKIGKHKKKKHF=KB@@HK@A?I;?GBEH;@JJ@A-GD;@>:EHGD3@CGGEC3JEJI8HFIJJKFKI6>8EBE;JF>?@IB/;3HJJHHJEC6HC:EIJ8IIHJEEIIHHKIFHGEI:KFKKHGCEAEFEFJEH@GGGEHGD:JBICGFJGKFJ?BCFDHCFFIKGIBGIIF4:?HDA7GHAEDHGEKKBHDJKGBCHIGJ4JC>6IAFIJHKBHHHCHC0?JHHIHIHEKG?JKHIBJ:BAA?FA7DED>1AFIB?@EKEF>==H;JGDJGECCE=@@:@DCIKI=DHIAJ?JIKGEGHCIFCFC>FIEICK:KJAG8IKIBCHI0E>HH@IK@GEHHIEB>K?CBB)FHJ>@BEI0KGIFCEIDGICA<8>;7A+?DHGG>EFDH@EF><;BI@GHCGFAGGB;EEJGHCAD24A82:DC7F3DEHG96FHIBAFFGE76FH8DHGCA9CD:F=?IC6I:59/>A:>8AB?H?9B>FFAHB=8D@HD:AGHACGAIF@GC77@BI@EC-EC>@@EDI?2=<98=':<8=CC9BB9=.?9+@??C=;>HA===C4>>BF8CA;H>>@C8:B6B?39=+4CC??BGD:A7==?E737@?EI>61D><;;911776=,DG;=A3.-ECCBE+FECGE?@H@16C?BFBCC67DDHFCII@CC@DI5IEAE+GJFIF5@(E@%==,BDCEI?6-A>BDB2<:G4DG>2FEDCFID5G?BJD>?75373:58J9D@EEC@AIEHEDHDA@HHF?C@?AE?EDCB?ED>F?:;A>E3D;AA:FFEHEFCCGEE>BIFGD<3GH8D8EHE@DHIIIDD=C;@GB4FIJFGF4G@H>F=CIFEADDA?ADIFFCDC?GIGCFH)FI1@@429-A@:45?FA?>D6E@4?F??F@.CB6149>;DA;DGE?DGGEC2B;FDE@A?=GEB6CC>?.,>B>5/#3?;9G;E=GCC0?>A@AD<7;7=@;@DBDB?D@>7E?CFF>;@=A><0195AF:@BD?ABA2?;?DFB=CCCEC@@)?C@=?DCC28>=?9)7B7:?@DC92E@7:;=;FAEFC77?(893A%?DC?;?:39@9:=DFD@@ED@>=DF;@>?6ABCBBBCD@CBD4A;@@FD< @rCer/1899/25_2022_CCS ATGGGGGACCGGAGCTAGTGAGGATCCAGCCCAGGCTCCAGTTGTCCGCGGCTCCTCCTCCTGTCGCTTCCCGTGTGATTACTGGGACTCAGATGGACCACACATCCCCGACCTACATGCTTGCTAACTTAACCCACTTGCATTCTGAACAACTTCTGCAGGGCTTGAATCTTCTTCGCCAACATCACGAACTCTGTGACATCATTCTTCGAGTAGGTGATGTTAAAATCCATGCTCACAAAGTGGTACTTGCCAGCGTCAGCCCGTATTTCAAAGCTATGTTCACTGGAAACCTTTCTGAAAAAGAGAACAGTGAGGTTGAGTTTCAATGCATTGATGAAACTGCTCTCCAGGCCATTGTGGAGTATGCCTATACAGGGACTGTTTTTATTTCTCAGGACACAGTTGAATCTCTTCTGCCAGCAGCAAACCTACTCCAGATAAAACTTGTCCTGAAAGAATGTTGTGCATTTCTTGAAAGCCAACTTGATCCTGGTAATTGTATTGGAATTTCTCGTTTTGCAGAAACGTATGGTTGCCATGACCTTTATTTGGCAGCCACTAAATACATATGCCAGAATTTTGAAGCTGTTTGCCAGACTGAAGAGTTTTTTGAGCTTACACATGCTGACTTGGATGAAATTGTTTCCAATGACTGTTTGAATGTAGCTACCGAAGAGACTGTTTTTTATGCATTAGAGTCTTGGATCAAGTATGATGTACAAGAACGCCAGAAATACTTAGCACAGTTACTAAACAGTGTACGATTACCATTGTTGAGCGTTAAGTTTCTCACTAGACTATATGAAGCAAATCATCTTATTCGTGATGATCGTACTTGTAAACATCTTTTGAATGAAGCCCTAAAGTACCACTTTATGCCTGAACATAGACTTTCTCATCAGACAGTCTTGATGACACGACCTCGCTGTGCTCCCAAAGTACTTTGTGCAGTAGGAGGGAAATCTGGACTCTTTGCCTGTTTGGATAGTGTGGAGATGTACTTTCCTCAGAATGACTCTTGGATTGGTTTGGCACCCCTAAACATTCCTCGCTATGAATTTGGAATATGCGTTTTAGACCAAAAAGTGTATGTTATAGGTGGTATTGAAACTAATGCGCGTCCTGGTGTCACTATCAGAAAACATGAAAATTCAGTAGAATGCTGGAATCCTGATACAAATACTTGGACTTCTCTAGAGAGAATGAATGAAAGCCGAAGTACTCTTGGAGTAGTAGTACTTGCAGGAGAACTTTATGCCTTAGGTGGTTATGACGGACAATCTTATTTACAATCTGTAGAGAAGTACATTCCCAAAATAAGAAAATGGCAACCTGTGGCACCAATGACTACAACAAGAAGTTGTTTTGCTGCAGCTGTGTTGGATGGAATGATATATGCCATTGGTGGATATGGTCCTGCCCACATGAACAGTGTGGAGCGTTATGATCCAAGTAAGGACTCCTGGGAGATGGTTGCATCCATGGCAGATAAAAGGATTCACTTTGGCGTGGGTGTCATGCTAGGCTTTATTTTTGTGGTGGGTGGACATAATGGAGTCTCACATTTGTCCAGCATTGAAAGATACGATCCTCATCAAAATCAGTGGACTGTGTGTAGACCAATGAAAGAACCTAGAACAGGAGTTGGTGCTGCTGTAATCGATAACTACCTTTATGTTGTCGGTGGTCACTCAGGGTCTTCCTATCTGAATACAGTGCAGAAATATGATCCTATCTCAGATACGTGGCTGGATTCAGCTGGCATGATATACTGTCGCTGCAATTTTGGGTTAACTGCACTTTGACAAATGTGAACTCTCGGAAATAGTATGGTGGTGAAACTTGTACTGCATGAACAGATGGCCCAGTTTTCTGAAACCCACAAGCTGCATTGCTTTCTTTTTAACTTGAAGTGGCATGAAGACTCAAAGTTTTGTTGGGTACTTTTCATTGACAAGTAGTTTTGGTTGCTCTTGATTACACAGTAAATCAAT + IH=JKKJDIKJJDDGHJJGJD7C?DIKHIIKKKJKGDEJEFBJHIDIIJ5HJJGKBDKJDJJAKJIKIK>KKKJKGEJHKKKJHKKFK;?I:3BEKCJJJKJKIH5KKKJIJKKGJJKIKBKEGKCKGBKFJ0KKJKKKJGKHKGKKHJH8KKCKHHKGKBKKJDKJ?KJJHKKHKKKIKCKEKGKGKJBKKJJJKKJH>I@JHDKKIJKJKKKKCKCEKKJIK>JJIF9KJHEKEHJK@KKJ7?KJKJJKJJK4KKKJJHJEKJJJJJKKJ=KJJIJDHJ=KJEIIHKIKJDK8KKJJJ1KKKICKKIJIKKKJJJKHKKDKHJKGCKJIGIHKJBJJKKKHJKJ@KKJIHCKJIJJHJHBKKJKKFG;IAJKKIC=KKDKIKBKKJIJ@KJKJJJJJJIJHKK@KK@KJFJKAKEKI?KEJJJJK6KKJKG6JJKKIIJG2KKKKAJDJGHJJJKJK>IJK3KJHEGH?KJI@KIAIIJHKGKKDKJGHGJ7EKIFI5DEEFHJ=IGG7KJKFHHBKKI=FKF6IFJJCEAJIGKJEI1HJEABIKKC>JJIKFHD@IJHGFKHIJCFJD=EJKJKEJCKKKCBHJKDHK6CAGEHIJ3GHIJKIGIGJK>6HJICJIH@HJJJ+DFJKJFI@>JHKJHAEAAEHJKIFHFGH=JIJEHJIIDBFJ8JIICKFK>KKED?@DHKIKKJI3IDIH0GAGKIBKHEHH>=IGJKIAIE?KKGHKJ@JCGF:JKIGGKFAF>=GJCGFAJI:EACEFBBCFJFKEKIHAFJJJJIEFGDKJF;IKCFGJGKKJI1H8BJKKDKIJ.DFGDJFKHH1IHDIG=DGKHJKJ@DJHH4IKHIGH=I@HFEGJKE>FIIIDEEAFD>;IBGIJIHHCHC;HE2HDCB@BBICA?GDHIDF?J>7GG1HGEJI7JDCGG4HKHIHGDJHHE=HJFJ@KHKDEHJIJGHJIF?IHHF?II;HDI>JE:JFIH=:FF@HFEIIJBEJJIJJIJEJFB7<+HJHHGFIBJHH?H@<@HIF=C?IJKGIKKHBD@EDGFEGGIKJHKBF:IGIFJCDBIHFJKF7JBHAIFDKG?GG8ICHJIIHEDG@JIDKIDJJEDDHGEJG@IIKJIIJKHJJ/>KJHAKGAKKIGFJDJBIFIDJGIKKHIKJJHJJIEIGCKG;IF3FJGJHCKKFFF?GEFE=IEE::@9KGHEKBHJEEE9AFFG7FHHJAHJHKG>JGCAJFKK@JCBKCEHIJKGKJEJE:FIAKKEF=BIAECIGAJII>KKHJKCIKJCB;IKCJ=II9HJAFHIKAIIF=@JE?JHA/FGIHGEFDG:HFD5G?HB?EJ@1ADGJEID1EE.JJAEGKJEJCAJKGKJJFHCJJEI;HDGIJF4JGDGCHHHJKJIFAEEIG@AFHDJEKJJEKJB;KID;6F8IGKFHHI@IJKHHKDIFFG=IF@FCHFIJJHG=>GJH(JJGC7E@IHAHG7305;-5,6)<998779*:?>;B6AC@1>508;?/6.38%3:=:-:<>@4>-><>546638493+)9@232341%6341,4:27:9*88,<1>:2=69672-B;%3=C716:)1@)9;?8/:8;%$??&44=;A=.=?C=?693<87&:@<4<4>=/.;%AA>;<;28;A>BBB5@::BA+<%96?405874=;59<>@=(::6?B+;A@@3853A9A;;A8-/8?7A>A?B:;<::>>C3/C3@76B;:C5<&==3<@(3738-'4:?:=/>5')9,/>?<:99<=;0<306=433;08&4;69=9>9-608;1#886=69->:<099;9>1<9:=25*:)48088:97&)2314'1:16+18;:;59<37=/:;7:6'77=.6938=;9=;9&7;=:74.5:5288:<':9?5<9<:7>>:7,)5>-6>.2>>;>1>5753955588(:$;85;0751:=9<;8<>261::3/'6(:=:=*2;288<*997'710?67;3%3:=89=98<>:4<2;>898>:936379:;9?=3;9=8;;'0=(=:54:4:<:8>1?3>=99*4<=9====>=*7=5<;=15=9:7<7=<65347+;99*18;3;56::7?45*;77883(580+31505&8269(93.5872--36&8/934399.893,0-/674'4995913996;88339-8588,9837898+09/79(18'2659852-,36'227870;93442636'4476#018349)14:0429:9+2./9:0884-668827593450806328,7';8;99:5+445526693:229075899*7%,546&8%+1.6-313858686319811.6&79-938;747/4..7%26958547'7885178%1500-4881:6:::,7579;5826$/1547(9:964(9880:-45/:640.*763/7.677455:3689.975454&9:9:84978-9014/778281376+-1805:29397833./49;38)9368'67358-835429489:624*,6835'&388)5348936:349836&.1596):3881354(2383446&:25:8:93347%25/154+2$,7242)134+866666442:.442518:::06,+%-*7-4414993059(8:56:3)+ @rCer/1904/25_786_CCS ATGGGGGCCGCCCAGGACCCGCAGCAGAGACGAGGCCTGCAGCAAGGAGACCAGGAAGGGGTGAGACAAGGAAGAGGATGTCTGAGCTGGAGAAAGCCATGGTGGCCCTCATCGACGTTTTCCACCAATATTCTGGAAGGGAGGGAGACAAGCACAAGCTGAAGAAATCCGAACTGAAGGAGCTCATCAACAATGAGCTTTCCCATTTCTTAGAGGAAATCAAAGAGCAAGAGGTTGTGGACAAAGTTATGGAAACACTGGACAGTGATGGAGATGGCGAATGCGACTTCCAGGAATTTATGGCCTTTGTTGCCATGGTTACCACTGCCTGCCACGAGTTCTTTGAACACGAGTGAGATTAGAAAACAGCCAAGCCGTTCCCGTAACAGAGATGGTCACACAAGAAAGCAGACAGCAAGGGCTTGCGGCCTAGTAGGAGCTGAGCTTTCCAGCCGTGTTGTAGCTAATTAGGAAGCTTGATTTGCTTTGTGAGTGAAAAATTGAAAACCTCTTTCCAAAAGCTGTTTTAACAGCCTGCATCATTCTTTCTGCTATATTAGGCCTGTGTGTAAGCTGACTGGCCCCATGGACTCTTGTTAACAGTCACTTAGGAGTCAGTTCTCAGTGATAAAGCGTGCACTGTGCAGCCCGCCATGGCCGTGTAGACCCTAACCCGGAGGGAACCCTGGCTACAGAAATTACCCTGGGCACCCTTAAAGCATCCGTTACCTTTAAAAAAACAAAGCCTTATCCAGCATCAT + .,14656,-,356114/+5355+0//554340246&02465501/3561406*26,41553+445544366456646662/15413.42,5.&442364136516/42434-4121516641322336252451+525266002./453$13445.246264521565655/42402636430553*-0664614660.64*//1-43.5625504+43224655034564106065*-6461442.42(262466525040335.24.354511155014145+)336515+55656645*546)013313,.&2.5360132323463656623&0%/.$22//9872196492581888.8553579:(5)-77,7(5546.468::96656743767875088787067::9395;:1*.)2170649745,92688868:,:567491885859:595658;865899;88.8745;;92499::68:::.59874;:3;;;5956+3789%4644:6432991974779+86/965,432::73::98466;98;8;8:82658+8446626698*665/5896788-95465;:8:3)075;54;998:566985556588..7978:99::::546858+99609.75;8;8569585892658189-883;9.76;498;:::4/7+764:78:23%31777<<&8/?>:97;8=;9<:3=2=5%;;;::;;9;<>7>:<8=3<:;8<6996 @rCer/1905/25_1689_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTAACCGCTCACACCTAGTAGCCTCTTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGTTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCTTCACACGAGAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGATTTACTTC 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@rCer/1907/25_1887_CCS ATGGGGCGGGGCAGGGCGGCTCCGCGGCTTCTCCCGCCGCCGCCGCCAAGGGGAGTTTCCAGGAAGTGGCCATATTGGATCCATTCAGCCGCAGCCGCCGGGCGGAGCGCGTCCCCGCAGCCGGCTGGTCCCGTCGCGGCCCCTGCGCTGGTCCCAGCCCGCCCGCCCGGTGCGGAGCTCGCCATGGCGGCCACCGACCTGGAGCGCTTCTCGAATGCAGAGCCGAGCCCCGGAGCCTCTCCCTGGGCGCCATGTGGTTTTGACAGCCTCCCCGACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGGAGACTGGCATTGGCAAATCCACACTGATGAACACGCTTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGAGTCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAATTATCTGCAGAGGAGCTGAAGATCCGCCGCTCGCTTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCCTGAAGTCCCTGGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATATTCCCATCATCGCCAAGGCTGAAACCATCTCCAAGAGCGAGCTCCACAAGTCAAGATCAGATCATGGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCACGGATGACGAGGCTGTTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGGCAGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCGAGCACGGCAGTACCCCTGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGAATTCCTGATGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAACGCCGGGAACTGGAGGAGGAGACCACGCCTTCAATCGCCGGAAGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTGAGGAAGGACAAGGACAAGAAGAAATCAGATATAGGAGCACACCAACCGGGCATGAGCCTCTCCAGCTCTAAGGTGATGATGACCAAGGCCAGTGTGGAGCCCTTGAACTGCAGCAGCTGGTGGCCCGCCATACAGTGCTGCAGCTGCCTGGTCAGGGATGCGACGTGGAGGAAGGATCCTCTGAGGCAGCAGCTCCAACACATGGGGCCAGCTCAGGACACCAGGGCATGGAACTGGAGACCATGGTTTTTAATGTTAGAACAGAAAACCCCATACTTTTCATATATCAATGACCAGAGCGCAAACAATTTGAATTTCCATCAGGGAACATCAAATGTTGCCCAACCCTTTTCATTCCTATCCATGGCTCCATAAGGGGCTTGAGGCTTAATGCCCACTCTGTGCCAAGCTGAGCTTCCACCCCAGAGAC 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#*$,-,'$0-0--&/.'*//1*000.-*&.*(022+&.*.0--2/*1-0&+*,/(+01*/,**#.-,)001+.+&,-211'/./01,)$',)%(+/.$.'-0/'.,%-1110%/00,1/)%+*,01+/'%,/..011--$/,)+)).-1/01022+/*,'+$()*).+/211112)'/,/,+001+0,*10.01200%(,-1101111-1111(,,1-,+1-.-$**'0/.,10-.1-,(&,)***.(''.'(-%&.(/+&/,-(,*+($')*(1.21-,1.1,+//0.+.01%&'-0',01*-11(*+%&&(0/$0-*1/2+--/00.&-00..++..*,(&+-+0*%(.10210.($,,,0*/++*'+#)/-0,-/%'*00.-+0&.'0/,,0,&+021021,.0/12'&,*&,,,*0+)/,...00+0.1)*'-./(&,)/*.+01&+,/*.0+'..)*%*,01-0)1/')-,1-/12.1.1-+.0/*.,-'((00-00.*-.#.'()00*,,'+02.*.00&-'.1./%-&0.,-10(.-*(.+++.,,/0101,)/.020(-///1-*'+.1*'(+0'/,-/&++&*02,+1,0.11*")($)-+*)*+.2/1..+)+$,+01+-./,*((1/*1-.-0+*---'0..1*0+1.&-.011-,).1...)'.-21.1201.,,//'0,00(%(*-,/0/,*0',-1.)00+,)'1+*&#$+$,00-0110,',&/(.-0)((&021-.*+/,1.1,+'(*11-1.+()-%.-21.10$---,,**-..-&+++4653323222+6425220+045,../42.60$0+00653/$*/0.40/4$..1(,2212%)+5/11,3.40-.044145,30+/1)10+3)54664-,-01/(/203.3/33635234(2011(330.4.14.04+40%,/4052/46431.-2241%53/23563631454%-('$-04,+%++5650465,*-356621646545(21.-5-22641/&(*3012,+,--/4(../$&&'+*0455425.266/,',))$+.05+12/5635/.#&&033,%04-.')533103,021/36626231(+.2+065,'(.)213154655*64,021*/.)0411..345120.03,1.602401612%)1/6(11/,$.2/*012.-+)3),+0'(-',.213/-*),132654*/.446566056553/1*/,$&/02//-4,-/0//3330,22/+,2)45%&/)/.5/3*44*0*300450.1)'3613'./2*53'05002211-.0+#'2350-4646'.04%)'/-.25*2-/0+/51+1232016./2&$%./)4461)..25555//.$+)32.6-221)0.5331.,,.20))*0(40/01550'0/-4+/330/5..*0/0*2-$,,1/4,5/.0324044,1/)0,,1%#%%,'+'000(,1/(5,/,,/3151./,2/2-1/062/000.46,2310.2*)(.1*0-)2/6.135236)/053140.443.030320/-%02).+-'/01)0/'052451,0.*'+013505,/*)+/1/-'1*45.--*$4&0'.)++%44.'(*33023355246.,/+)),'211-/03,+0*)0)'&+/*%(/4,525*1.5+6220(+)/+4'2330(023)+(+0-4/,0266+/43+324&23.0--/+,',-+2--,.'($2+0*)30.-/-240,314.,+2/4.(/-&/565-,31).,2.)40'3)1,&/2-/30.(*--*,104+342/3%/+/+61,--0+*%0*)30,1216/5522664%/0,3..0515/12/3.(./20..44' @rCer/1909/2032_77_CCS GCATGGGGCAGACGTGGAAGCCAGGGGACGTTACCAGTTATTTTCCTACTACGGTCTCTGTCTATACTTGAGAATCAGGTCTTGTTTGTAACTTAACCTGGTTTTACATAGCGAAAGAAGAAATATTGAAGGCTTAAAGTTTGAATGGGTCAATGGCTCATAATTCATTAAATCTTTTCTATACAAGGAATTTTGTGGGTTAAGTGTCCAATTTCATAGTTGCGCATTATTTTTCTTCTTATTTTACTTTGATGTTAAGCCATTTTATGTTCATCTCCCCTCATTTCACATTGAAGAGTGGTAGATTTACGGGCATTTCGATAAGACACCTAAATGAAAGTAAGATTATACCTCAGTATAAGTATGTTTGAAATCATTGTTCATTTGATTAGCAATTTTCTGCCTTTTAGGAATGATTAATTGACTGGAGAAGAGTTTTCAAAAAATAGCATGATCTCTCGTTAACTCCTAAAAATGTATAATGAACTTTTGTTTGTTTTGGAAACAGGGTCGTCACTCTGATTGCCGCTAGGCTGCGGTTCTTGAACTCCTAGCGCCTCACAGCACAGTCTTCCTGCCTCAGCCTCCTCAAGTAGCCTGGGATTGACGAGAGTGTATGCCACCATGCCCAGTCTTTTAACTTTTAAGTTCCGCCATACTATGAATTTATCTTGCTTCATATTATATATTATTATTTTTGTTGTTGTTTGTTATTTTGAAGAAGCGGAGTTGTTTTGAAGATGATAGAAGGTGGGAGTGGTGTGTGTGTTTCTTTTTTTGGAGACAGAGTCACTCAGGCTGCGATCGTGCCGACCTGTGCTCACTGTCAAACCTCTGGCCCTTCCGCAGGTTCCAGCGATTTTCCTGTCCTCAGCTCTTCCTGAGTAGCTGGGATACAGATGCGGCCCAGGCACCAGAGCCTGGTAATGGTTTGTATTTAGTAGAGACGGGGCGTTTCACCATGTTGGGCCAGGTCTGGGTCTTGATGCTCCTGACCTTGTGATCCACCCGCCTAAGCCTCCTCAAATCAGTGCTAGGATTACATGGTGTGAGCCATCCGCTGCCCGGCCCTAATCTTGTATTTTTTAGTAAGCGGGGTTTGTGCCCATGTTTGGCCAGGCTGCGTCTCGAGACTCCTTTGGCCTCAAGCTCATCCACCCACCTCGCCTCCCATAAGTGCCGGATTACAGTGTAAGCCACCGTGGTGCGGCCAGAAATTTAAGGAGTTTTAAAGGTTAGCATTGAAAGGATTACTTTCCATGAATATCTGGAGACCACCACAGGTTCCATCAGTTGGGACTGTGGTAGGATAATCAGGACCACTTTGAAGCCTTTACTAGGGATCAGGCCCAACCCCGCCCAAATGCTGTCCTCAGAACCTTCCTCCGTTGTCTCTAGCTGAATTAAATCTCTTCCTTGAAATTTCCCTAGTTTGTTATATATCTAGTAGTTGATCATGCTGTATTATTATACCTTGTTTAAAAATTATTTATTGATTATTTACGGGTGTCATATCGCCCCTAAGACTTGGGACAGGATCTCTGACGGACTCATCTTTGTACCCACACCACGTATGCCAATAGGCAGTGTGCTCACGTATTTGCTGAAGGGACAGGAGAAAGAACTACGCTTAGAGAGACAAGAGCTCCTCTGAAGTTTAGACTATAGAGCAAATAATTACATGTTTAGCGAAAGAGAGTATGAGAAATTGCTATGTTCTAGTCCAGTGAAGCATGAAGGAAAGGGGTGGCAAACTTGGAGGCTGAGTAAGGGAAGAAGTAATTTACTGCGATGCATTAGCCATTTCCCTCTACTCGAAAATTACTGGTAAACTCTGATTTTATATTTGTTTAGAATGTTAAATAATAGAATTTTCTGTATGTTATTTTTGGAATTCTTGTTGTGGTTGCCTTAGTTTCTTTAATAAGAAGTTAAACATAAATAAAAAAAAGAAG 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@rCer/1910/2173_58_CCS TTGGGGAGAGGAGAGGAGCGGCCGGAGCGAGACACTTTCGCCCAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCCGGAGCCGTCCGGCAGCATCGCCAACCGGCGGCGTCCACCTCGCCCAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCATTCGGCGAGATCGTGACCGAGAGCACCTGCGGCGCGCCATCGGCAACATAGAGCTCGGAATCCGATCATGGGACACAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGGACAAAAGATCCTTCATCACCGAAGTGACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAAGCAGTCAGCACTGAGGTGCGTTTAATGATCACTGATGCTGCCCGACACAAACTGCTCGTGCTGACCGGGCAGTGCTTTGAAAACACCGGAGAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGATTTTCACCGACCAAGAGATCGGGGAGTTACTAAGCACACCCATCCTGCTAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGGACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGATTTCATCAATATTAAACTCAATTTCAGCTTCTATCTTGCCAGAAATGGAAGGACTTTCTGATTTTACTGAGTATCTCTCAGAATCAGTTGAAGTCCCATCTCCCTTTTGACATCCTGGAAACCTCCCACATCGGGTGGATTTCTGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGGAGGGGAGATTCTGCCTTGTTTGCAGTGAATGGTTCAATATGCTCATCAATGGCGGATCGGAGAGAAAATCCTGCTTCTGGAAGCTCATCCGACACTTAGACCGAGTGGACTCCATCCTACTTACCCACATTGGGGATGACAATTTGCCTGGAATAAACAGCATGCTACAGCGAAAATTGCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACTGGATGAAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTTCTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGAAGAGAAGCATAGAAGAAGCATGCTTCACTCTCCAGTACCTAAACAAATTGTCCATGAGACCGAAACCTCTGTTTAGAAGTGTAGGCAATACTATTGATCCTGTCATTCTCTTCCAAAAAATGGAGTGGGTAAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGCAGTATTTTATGCAGCAGTGGACTGGCACCAACAAAGACAAGGCTGAACTCATTCTGCTAATGGTCAAGAAGTAGATCTCCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAAAAAATCATCCGAGTCCTGTTTCCTGGAACAGCAACCAATACAACATCCTGGAAGGGTTGGAAAAACTCAAACATCTAGACTTCTGAAGCAGCCGCTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCACAAAACCACTTCCTAGCAAATCCGTGCGCAGGAGTCAAAAGAAAACCCCTGAGGTCGCAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTTGAAAGCAAAGAAAAGGTAACAGTGAAAAAAGACAAGCCAGTAAAAACAGAGACCAAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAAGAAGAGCCATCTCCAGTGAAGGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCCGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGCAAAGCCTGAAGACAAGAAAGAGGAGAAGGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAGAAGTCAAAAAG 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@rCer/1911/1514_57_CCS GGGCCAACAACTCCACCTTCTCTCGTGTCCTCCTCAGACCTGATGTCCAAGTGGCTGGGGGAGAGTGAAAGCTGGTCAAGAACCTGTTTGAGCTGGCCAGGCAGCACAAGCCTTCCATCATCTTCATCGACGAGGTGGATTCCCTCTGCGGATCCCGAATGAAAATGAGAGCGAGGCCGCCCGGAGGATCAAAACGGAGTTCTGGTCCAGATGCAGGGGTGGGGAATAACAATGATGGGACTCTGGTTCTTGGAGCCACGAACATACCATGGGTGTTGGATTCGGCCATCAGGAGAGGTTGAAAAGCGAATTTACATCCCTTGCCGGAGGAAGCTGCCCGTGCCCAGATGTTCCGGTTGCATCTGGGAGCACTCCCCACAACCTCACGGATGCAAACATCCACGAGCTGGCCCGGAGACCGAAGGCTACTCGGGTGCGGACATCAGCATCATCGTGCGGGACTCCCTCATGCAGCCCGTGAGGAAGGTGCAGTCGGCACACACTTCAAAAAGGTCTGTGGCCCTCCCGCACCAACCCCAGCGTGATGATCGATGACCTCCTAACCCCATGTTCACCAGGGGACCCAGGAGCCATGGAGATGACTTGGATGGATGTCCCTGGGGACAAACTCTTAGAGCCTGTGGTTTGCATGTCGGACATGCTGCGGTCTCTGGCCACCACCCGGCCCACGGTGAATGCAGACGACCTCCTGAAAGTGAAGAAATTCTCAGAGGACTTTGGGCAGGAGAGTTAAAAGCTGCTTCACTTGGGCGATGGTGAAGGTGGGAGGTTGATGGGGGCAAATGCAGGCACTCCCTGTGTCAGCAGCCAGACAGGGCTCCAGGGCTTGTCCCAAAGTCACTACAGAGTCCCCTCTGCTGTTGGCTGCCTGCCAGGGAGCCAGAAGCAAGAGCCTCGCAGCCACAGACACTCCACCGCCCTGGGGCACACGGTGGACACTGGCTCTTCCTACTTCCTCCTCTCCTGGATGCTCACCAGCTCCTTCTGCCCCCCTTTTTTTTTCCATCTTTTGTTCCCCTAATTAATGCTGCTTCGATTTTCTCTTGTTTATAAATAAAATAAAATCACCTGGAAGTATCAAGGAGGGGGGGCGGGGAGCAGCCATGCTGCGAGGTCACCCAGACCTCCAGACAGTTGGCTAGCTCACTGCCCATTCCTTTTACGCCCAAGTTTTGCTCCTTGAGAGCAGATTGGCTGATGACCCTGCATCCCAGCCCAAGCTCTGCTCAAAGACTGAGTGACATAAGCCATTCCCCACCCTCCTAGGTTCACATCCAGGGCTGTGTCTTCCTTGGGGAGGAGATGGTGTCGTTCAGATCAGGGAAGGCAGTCAGGCGGGTGTTCACTGCCTTTTCTTCCTGAGCGTGAGAACACTGAACCCAGCCACTGCCCCTGGGTCCCTGTCCTGGAAATAGTCTAATAAATCCTTTTCCCTT + $(.002-,.()%+(3)0*',"25"&36-9)223/6795:4030.98/3:243934,9:98*53,65454$89.9534917;.=.6046%=;::79/;,:9+:2>;><6666,63=:<86:)2938:06,(781.647=164#22;95)8<:7/8:5:8.9169=(=8;966<=>9:782259666$&)37-/572367846#(64-&+*&3%4;60<:101'25/(11.,/99/755772+<>76;7<;>28;992;3=7;*<300:32)807.&/.,'6%+$,+,9-24:?.79.1=86<9%6/27)809=275=<<=:;2:/5:6/+/32-8/;899:4:7732(8=%15/;32689)74<193,6)6=3=97411001'954883'(421650:9%09A4:;-@2;>?>B>@5./,2@=69643072')4.316&,69<0:94==*<9-7;>3:?<):=>+C<>7A=A<<471;%%,5@8;.::>9;674&259B:7@C;98$(3:2=850%;%062+';,.0,7?16?>97<-7=8);4<7<@??/8C<<8=656=0;A;7;67/9,4<138>697;3%02A&;;?<(9C;;.=;95)4>5@@1=>7<46>2@B8;B>:GBA@AA>=@D@>:>=CC?@;<,73.54;6;3=,-15:62;?<@855-2<74A9B<=B@=<&C?>1@B:DB>><6BB@;A@=2<8@;?@6D@;>5?@5A@B4E93C<,825>:(/>5?9>@;:@??/;@<06B?:A8;AB95<,:>1?BBB;<@C;5CE;;;)35E@/87'?;8<493@678>;EA;;A?E?=$A=6A?G;BFC<;6;7D:A;B:::98@685/6259A@9=:6C;:>8C>92>04<0/96/>A>9/043)6>>B/@*=5+;/;5+2=/=?*71@FCCCC<@?2@=@7<>7564$(98:80.4&C@+A@BAE4=C:524981F>@A:<-#.=A;=<60.1=?,<=BA%>85=&A:+69=>9935897;D4C>:519)/?>8%4;6;==7:8>?69B=?B4B>=??'2@?E79F6EFEE.A:.A8C>;;40&+=9A:9,381:67AA-G?;???'B3DE:E1D;65;:6-58+FB98>>@C@D533><@;@>',,CF5@,BB@FB<$@@9;,;AC:8.323=54@?6=A??5-++8:,(-'<63.77<5:7;9+=??1??>A;?<@/E8C9?36/C=77;>=?>4;?F<>6B6@;>;3:B$((=1F=:@:@@=?F>6A1<%1ABBCE0B>;/41-9.6B:C:;261;;7>>62144?<170A6>-3;F48:A2FC0=8EA/C>';2>9:07147456998><:74:<47;58&96;=5789;5;>?*;>86<=885>@;1<;6;7AB=48<>><?=?1<>27@9>54=6%535><9<=87255;76@5=<07?@:A;;?88>8A990@@;A965/B>=0511,1'6;963>=<<=23=.9<0@=629/4479A0???C@3<>?;?0=-9B?7.@7465=:3.746982(2;<<>=60=;>=55;<2ACCA6<@8A5>:=?B6:34A)?=::>697;8$46094<<2=>??B3:8:=::*87:>;<;BA0;6<4@6386ACAC?E;E8CBH2>:<0?>;B5>/;G@(@3=B128:6>;AB;4D:E;44?5A7?EDBEFA@5?7;@=830/80::>ACECG;(7C?G?KDIID@3HCAGADEGAHDDBAB3@<6->AA>CA/2,6+;GF4BE:?C5GE9GH@2CDE:ABF4=BA2=B7G<56ADKKJIF@EB7GA;G;@IBIHKHHA>FAA;HF>4D>HJA:G;:BHE?JJ>FE;HGHBHFFHA/JIJFG9GBGH:3GGKH7KDJF=?%GA?@@>7@B=BG5;B4=2=:<89?;@GHDAF2FC2B=4A?@@:@@DE@5DADD9CBHGIHACCFDB@-*6&A@A?8:C@9@?9;:;3=$;@DDB>A:EGF;05@B?J4ADAH?E=5=<7;.BJGHJGGADAII6GDD8?=3F=DGJEEF?;E58D:035?HF8AIIBA7@+CB@KG97=BGB9JE7=,H?GBH<6;<=GHC>?JB1@BAGFD>BGHB>B?ED?:F<4IC8>B5;JJ>IGEAGIGFHB@J8;G2GJHH4EJHF4G/HA;FIH:D>GDHJHI>KJJEIDA==>8.ICCFI>JC?ECFHHIID>@ICB-;=649JAA@GI;DFD?F/;C;0I&C18=>ADDJE;8$EDCDA8KEGIFADFA;EDIB>H>E8&EI@BE2B<4ID4GEGI?>H5??G???FACG22&@A@1;7+BGFEDBB7IGHIGHCHH:EIJ2EJBDA<:C=IA9FFIAKEG?IAEGGB69DIFFEB>H8JJKHIECD>A6AA.;>;H9FFH=DH?KHJHI;HG;>A?D8JHJII=9JI-D@FG?IJGKKG@8-/.@:/C;?F=;==>58=8=6>><:>9%9;62+65-55,>537;,;;5824<75><:<855+983:?=8<576>=89:7:>:;::87<99?>>9*=9+:;:=,:>88:#:57=9=4979:&548:=:07,;7;:;?=>8264;6><:4:?;989?4478?8;>971.7=;52=92;0;><87885<1195.=:2=<>,841;=8%.>7,=3:<:8?=-<<7>:+:63147<824<.:$26),4:7'/73:7:;8??;7?7=80999::?8<=4:<57;*:63841(1,<=>>72;0;9;;8==<=->;9:5=:+748=<7772<:319:86<0::=>:?68:+25-0:>>9::;?<4?=:47/:;?>?=+:79>===;68.=:6:;7>>83;*:=6>==9;/<:)=<:<;<6;;;<:;*4:-8==4>/;>=;756<065=/859:<85+7=98+249;7*<83)6<<685187>987861840;8698;;?9?>=><386>7<=3;3=::8:919>0;;25#*5/7,:6611*05;9=:?<7*899;+<<+790;;8;$79::4=904839>36<829++29(478?;>6+8-=34=8=;>780*6244;<>>8?46*5:=973:$59:::9:9(26<=337:8/<<2=4?:;77<.=997359<5:::98?=4?0:,7.(1,*9684;:2:;=<<4?5??<<<7<$9:5:8690#+7,'58<9999<=:6=2:4:%525956=:82<19?3:99=7<)99985:98=<1+1<+0.23344,02114$,3853171<=:;;,:=9485>;96=85;794>:6;:9=;>?<:<*2159:16997=>1;7079<93=9=/49;)918:;0;428*:;<<9:8618;6789>4694;4:)783:803444=8:718)29:=965/34:9:;6:829<268625/5;9?8<,9&6787694><>><=;;<3<;=<:=7<6:<529:=>::?3?;8:85??>6=9====;?3??;1::2.96==28?<9?=?>:897:982;>8;+<;66:9$8685959>7470<<*675/5;>;:;>4<:/:.:; @rCer/1915/1810_51_CCS ATGGGGCCTGTCGCTGCGCTCGGCTGAGTCAGTCAGTCAGTCGGAGTCTGTCCTCGGAGCAGACGGAGTAAAGGGACTTGAGCGAGCCAGTTGCCGGATTATTCTATTTCCCTCCCTCTCTCCCGCCCCGTGTCTCTATTCACCCTTCTCCACCCTCGCTCGCGTAGCTATGGCGGAGCCATCGGCAGCCACTCAGTCCCCTTCCATCTCTCGTCGTCGTCCGGAGCCGAGCCGTCCGCGCCCGGCGGCGGCGGCGGGAGCCCAGGAGCCTGCCCGCCTGGGACGAAGAGCTGCAGCTCCTCCTGTGCGGTGCACGATCTGATTTTCTGGAGAGATGTGAAGAAGACTGGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTCCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTACCTCATCCTGGCTCTTCTCTCTGTCACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCATTCAAAGCCTACCTGGATGTAGACATTACTCTGTCCTCGAAGCTTCCATAATTACATGAATGCTGCCATGGTGCACATCAACAGGGCCTGAAACTCATTATTCGTCTCTTTCTGGTAGAAGATCTGGTTGACTCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTGTTTTTAACGGAATCACCCTTCTAATTCTTGCTGAACTGCTCGTTTTCAGTGTCCCAATTGTCTATGAGAAGTACAAGACCAGATTGATCACTATGTTGGCATCGCCCGAGATCAGACCAAGTCAATTGTTGAAAAGATCCAAGCAAAACTCCCGGAATCGCCAAAAAAAGGCAGAATAACTACATGGAAACCAGAAATGCAACAGTTACTAAACACCATTTAATAGTTATAATGTCGTTACTTGTACTATGAAGGAACATACTCAGTGTCAGCTTGAGCCTGCATTCCAAGCTTTTTTTTTTTAATTGGTGTTTTCTCCCATCCTTTCCCTTTAACCCTCAATATCAAGCACAAAAATTGATGGACTGAAAAAGAACTATCTTAGAACTCAGAAGAATAAAGAAAGAATCAAATTCATAGGATAAGTCAATACCTTAATGGTGGTGGAGCCTTTACCTGTAGCTTGAAAGGGAAAGATTGGAGGTAGAAGAGAAAATGAAAGATAGAACACCTCTGGATCCTTCTATCCAGTTTTCAGTACTAGTCTTACTCAGCTATCCATTATAGTTTTACCCTTAAGAAGTATGATTAACTTATGAAAAAATTATTTGGGGACAGGAGTGTGATATCTTCCTTGGTTTTTTTTTTTTTTTTTTTTTTTTTGGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACTCCTGGTATTCCTTTTCTTTAGTGATTTAACTTTCAACTTGATGAATAACTTATAGGTGATAGTGATAATTCCTGATTCCAAGAATGCCATCTGATAAAAAAGAATAGAAATGGAAAGTGGACTGAGAGGGAGTCAACGGGAATGCTGCGGTGGCCGCCACTCCTCTGCCACTATCCCAGGGAAGGAAAGACTCTGCCATTGGGAAAGTGGCTTCTATGTCACTGGACACCAGTTCTGAGCATTAGTTTGAGAACTCATTCCTGAATGTGCTTTCCTCCTCTCCCTGCCCACCTCACCTTAAGTTTAATAAATATGGTTGTACTTTTCTTATGATAAAATAAATGTCTGTAACTGCT + KGHKH(KKKKJKKKGEBKKK5JKKK)JII?=GGF?G3>>IJ7EGKHK'*JK5JHIJHKKKJF@IKJK?KHKKBJKK6JEKK4KFJK3IDKI6FGEKJ%KFK@FF<-&8EEFJKKKKHK5B'3>KGKHEK>JIKGEFFK8(K5KKFBK>KIHHFK>KGKK*HJ)94D)KJHH&IK%DIK,JJBKIKIIKDI@E?AFKEIKKJKKKJG1JK9IHKICKJ>KKKK6IJKKJHKKKIFCDK9KG;AJGJKHKEKKKKJ6?GJJJJC-K)GKFKJJHKI7IKJKJKJEIJJACIEK4KK)I&DD+KFJKKIKIEJF9KBKKJKKHKKA8K8KFKKFIKJKJK6KKFIJJKIKKK9KKKJJKHKIJKKKGKKFKKA=KKKKK>KKEK@F&IKK=JKFKKK5GJ5KIKFFK6@>JKI=JIDKG=@DIKKAJK?JJJJIKKK%AIKKEKKHK?KJIIK;KDKK?IKKKGKKKKJKKGEKKKKK1K7HKKIJK-K2KCKKJIGIKCDK8JKJKJ8G2K%IKIKGK3KKIKKHJEKHKAJIJKKKK,=DFAKGC9IKGKBHKKK4KKGKBKKKK&KKKKIK>KFKKK224KK%KJKFCIJIDKKJGKK&116DJKCKKHHKKKKJK>KK9KI4F'79>?KKICFDGH8;JIEKK)JK0KK@J=GK0KKKDKKEHKHKKBKKKKJ/K8JJJKFIIGEJIJ<,BJ@IKKEKJ8JKKC*CHEIK8CK7BIHEIGKKHJKK:/KKK?IJKKHJKKKKBKKGFKH/IKHJDJ>KBKH.CJCKBEKJIKK:KIKK;KKKFGKDDFA(IA?KAJKK-KIKKEII8JIKKK1HH:FG296%D?KCK<@EH7KDK4KKIFH.KKK9KB=IJHJJKKKK?K;KK=EDIK(JIJJK;CJIJHKE/GHK(KD='KK/HBK:KKIK'FI#;KAKK3KKKID6>IKC1HF?K5;KCKKKDCKK,KFJKKAKDAKBK>HIFCKKKDAK:KJC5BKKJ0HKK4JJKKJKFKIBJKK? @rCer/1916/0_1236_CCS TCTCTCTCTGTATGGACCGGAACGGGTGGATTAATGCAACCGCCATATGAGTTTGGAGGGATCCAAACAACATAGATGAAAATGAAAAATCTGGAGAAGGAAAGTGGTAATTGAACTCATCTTCTGCATCCAAGAAATAGGAGATCATCAGTATACAATATCTGCTCAGAAAAACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTATACTGCAAGCAAATGTGGTGGTCATGTGTAACAGTGCCTGCTTGGCCATGCTTTTGTGCTAATGGACCATATCATGATAATGAGCCTACCTAGTCTTCGCCCAATGTTGGATGTTAATTATTTGCCACTGACAGACATGAGGATAGCACGAACATTTTTTTTTACCAATGAAGGACAGGCATTATACCTCGTCTCTCCTACAGAAATTCAGCGGTTAACATACAGCCAAGAAATGTGTGATAATCTACAGGACATGCTAGGAGATTTGTTTACTCCCATAGAGACACCAGAAGCTCAAAAGAGGCTTTCTTAAGGGACTGTTTGGTGGAAGTGGACAAACATTTGACAGAGAAGAGCTCTTTGGGGAAGCTTTCAGCAGGAAAAGCATCCCGCAGCCTGCGCAACACATTCTGGACCAGGTAGTATAGAAGGGATGAAAGGCGCTGCTGGAGGGGTGATGGAGAGCTGACCCGTGCACGAATCGCACTTGATGAAAGAGGACAGAGGCTAGGAGAGCTGGAAGAGAAAACTGCAGGCATGATGACCAGTGCAGAAGCATTTTTCCAAACATGCACATGAGTTAATGCTGAAATACAAGGATAAGAAGTGGTACCAATTCTAACTTCTAAAGAAGCTGTGACTGCTTTGAGAAAACCTATATTCAGGGAAACCAAATTTATTCCCAGCATCACTATTCAACTGCTAGAAGCCAGTTTCTTCTACAAAATGTTCCATTTACAGTCAATCTGAAATTATCATAAAGGAGATGTATCAGAGACGCTGTACAACCCAAAGGCTGAGCCTGGTTAAAATCCCAAGATATGGCTGAATTTGCCTTTTCCATGGGAATGGAGCTATCATCTTGGCATGTCATTCGATAAGGATTTATATTTAGGAACTACGGGAAGTCCTCTTGATTTGAAAATCCTGTACAAACAAAGCATTAATGCACTTAATGAAAACAAATCTTTGCATGATAAATTACATCTTAAG + S%#$''#"''#$/('$-2&%*,&$&"%&)(,-'%)*+'*'($$*'+)%%#'&,,&(+&*&%%%($)&&#$&#&'&+*(&'()*)+*--+)*$&$(%$(*-(+)((",+).$(,(,&'(('&%'$**(+&#*&+'$$&&*(')(),-+(+,&)+,,,*,($),*,)*)(%$*+*+*')*))*.-*,---)'))%$%'-',+-,,*-)&+,,,',,+*'%)+&(,.,'&&++'++,+**'%&,'%''--,,+&(*+-)$$$$%$&()%*---,)),,,(+)'(&#))%(,%$),-,(-,*--*)$%')#$&"*,*+&+'(&+*#&)'(&&,-+)),(',(,-&+$++++#,*+(*$+-,(&-'+)%((+,-'(------))+-,,(,$$())(&((-*'%&&$$$##')+/(.//&.'+///.2*$&$),'%),/,,,1.0,/-01-),22/21.+.*/&-*/'+,%-*0+.%/01221/11,,0*/21,01.1.--.1-(+-/*..0**0&%#///0*+0/+(&))-/-,--,*.211/+%,.%*++20*.0,(+,2))0.1/.)+('$**..,-0&+,+(*&)*$//,-))+*,+.,,-&-0,--%1.0)-1,%/.+./-/-/%'+/.*//.00.,&&)*$+.-.*0*/')*+$./2100&&-,//%,.*+()(/,+).*.-%++.-+-,(*.-(1+2/+*+&),.//(/,0102,11.*,01211.,&/'.,010'0-/1,11.111,1/-,+,*'-',*%0%+((')-.-0/0--0.*+***/0%.*'(-/,-0/11,-&/..000).1((,-0-00&,0%'10211,/11221),(002*0-20*,-.*1.&-2,,-01,00-1210)10'*,*,&'%**+,++()''%'%,0102$),&&/,1'-0*/+'0)0,$+/))+&+*'))-)+,1/,&.1-/1.1/(+0,.1.2.1%/))&..).1*/**,0*&*(%(,.-1.02..0*,*/&-(-/,,,)$%)$)+1./-/0//,(0(),1111,,.,)1,1--21(.*,&-+&*''+)/)-.-**/0,(-./0,(-&*'%-((%),-&*,&$,*''",+.--.,+'&+(#()+)*,.,(-,$%##$&&#)"$,-,&('&%++-.*),(,()+('--,.,)(,+)&,,-)---)--'$$)-,(+,),*(-.-))',.-.,-,&*$)'(+,&--,*%*+-+*--(*(+-('&+)*)$%'*'*.--( @rCer/1919/2460_53_CCS ATGGGGGACTCTCGGCGAGCAACGTCGCCCGCGGAGCCGCGCTGGTGCTGTGGCCCGGGCCCTGGCAGCCCTCCCGGGAGGCGAGCCGGGAAGGCGGTGTCCCCTGCCGGGTGCGGCGGGGCGCGGGAAGAGGCGGGACTCTTTGACGCGGCGGAGGGGTCGGGCGGCGGCCGACGCTCCGCCATCTTTGGTCCAGTGCGGTGGCGGCGGCGGCGGTGGCTACTGCTGTGGTGAAGGAGGAGGAGGAGCCGAGCGGGCGCTGCCACTGAGGCCTGACCATGGACGAGGAATACGATGTAATCGTGCTGGGGACCGGCCTCACCGAATGCATCTTGTCGGGCATCATGTCTGTGAACGGGAAGAAGGTGCTGCACATGGACCGGAACCCCTACTACGGGGGCGAGAGCTCCTCCATCACACCCCTGGAGGAGCTGTATAAGCGTTTTCAGTTGCTGGGGGGGCCCCCTGAGTCCATGGGCCGAGGCCGAGACTGGAACGTTGACCTGATTCCCAAATTCCTCATGGCTAACGGGCAGCTGGTAAAGATGCTACTGTATACAGAAGTGACTCGCTACCTGGACTTCAAGGTGGTGGAGGGCAGCTTTGTCTACAAGGGGGGCAAGATCTACAAAGTGCCGTCCACTGAGACTGAGGCCTTGGCTTCCAATCTGATGGGTATGTTTGAGAAACGGCGCTTCCGCAAGTTCCTGGTGTTTGTGGCAAACTTCGATGAGAATGACCCCAAGACCTTTGAGGGTGTTGACCCCCAGACTACCAGCATGCGTGATGTCTACCGGAAGTTTGATCTGGGCCAGGATGTCATCGATTTCACTGGCCACGCCCTGGCACTCTACCGCACTGATGACTACCTGGACCAGCCCTGTCTTGAGACCATCAACCGCATCAAGTTGTACAGTGAGTCCCTGGCCCGGTATGGCAAGAGCCCATATTTATACCCGCTCTACGGCCTGGGCGAGCTGCCCCAGGGTTTTGCAAGATTGAGTGCCATCTATGGGGGACGTATATGCTGAACAAACCTGTGGATGACATCATCATGGAGAATGGCAAGGTGGTGGGCGTGAAATCTGAGGGAGAGGTGGCCCGCTGCAAGCAGCTGATCTGTGACCCCAGCTACATCCCGGACCGTGTGCGGAAGGCTGGCCAGGTTATCCGCATTATCTGTATCCTTAGCCACCCCATCAAGAACACCAACGATGCCAACTCCTGCCAAATAATCATCCCCAGAACCAGGTCAACAGGAAGTCAGACATCTACGTGTGCATGATCTCCTATGCACACAACGTGGCGGCCCAGGGCAAATACATCGCCATCGCCAGCACTACTGTGGAGACCACGGACCCTGAAAAGGAGGTGGAGCCGGCTCTGGAGCTGTTGGAGCCCATTGACCAGAAGTTTGTGGCTATCAGTGACTTGTATGAGCCCATTGATGATGGTTGTGAGAGCCAGGTATTCTGTTCCTGCTCCTATGATGCCACCACACACTTTGAGACAACCTGCAACGACATCAAAGACATCTACAAACGCATGGCTGGCATGGCCTTTGACTTTGAGAACATGAAGCGTAAACAGAACGACGTCTTTGGAGAAGCTGAGCAGTGATTGTGGCCGCCCCCAGCCCCTGCTGCCCCAGCCTGTGTCTGTTCTCCTAGAGGGCTCCAGCATCCTCTGCTTCCCCCACCACGTTCCCATCACCCACCTCATTGATCCACTGACCAAATCCTTAACCCTAGCGATGGTTTGGGAGATGGGGGGTTGGATAGCATCCTCTTTCTTGGCCCTTCCTTATCCTAGGAAAAGAGGGTTCCTCTCCTTGTGTGTGTCTCTCCCCCCACCCCTAATTCTTCTGCTCTGTTCGGGAAGACGGGGAGGAAAAGGTGACTTCTGCCCCCACCGCTCTTACCCCCACTGTAGTGGCCTTTGGAGATGCCCCACCTCCCCCACCAACTCTTGGCGTGTTGGAGAGAAGGGGCCCTCCAGCACAAAGTTGCATTCCTCCCCCCTAATTTATTCTAATTTATTAACTTCGACCCACCCTTTCTGAGCCTGCAGCCTTCCCGTGTGGCCTGGGGGCTGTAGAGTGAGCTGCCCCAGCCCTCCCAGCCCTTGCCCAGCCTGGGCAGTGGGGAAGGCTTGGGCGTGGCCCCGTTGGAGGTTGATTTGCTGTTTTGTTTCTTGTCTTTGTGTTTGTGTTCTGTGGTACTTGCTGAGAGAAAAATGTGAGCAAAGCAGAAGGAGGTGGGAAAATGGACCCAAACCCCAGTGTGCCCTGCCCGTACCTTTCCTTTAGTGGTGGGAAACCCTTATCTTGCAAAGTGAATGTGTCCCCTTCCCCACCCTCTAGTGTATTTCACAGAAAACAAAACCTCCCAATAAAACGGTTGAAACC + >KKKIH$FKJKKJKIKJJJIK?KKKKKKKBKKKIKJKDKJJADKGEKIKKKKGKKDKK;KKJKIAKKKKKHKJK0IK%JKKJIKJJJKKHKCKJJIJEKGKK?EKKKFHIKK7KJFKKCJ=JGKIIKKIEJHJHH2JKKKKHGCH@KKKK:@GKIGBADJIIKGJGJCIKKKKKIKJIJKAK??JBHI@CBKFKKKJKCDKFKKKCKGKKJJGDJKJJHJIEJKKKJKJKKI>KFJI@IJHFDK@AEGKAFKKKBKJJKHKKKIKKKIKEF?E=C>EEJIGJBKKJKFG;FJK=EJJJDKJKKE(B@BHIHJKKJKKHHKKGIBJKK9KFI@J:FBAB7E?IBHJHCIJJ,EFIJ?KHDHKKKKK*JKHJ6IEECIIGKAKKDH8IJFEJGJJKEG:>@IFFHIIIJKH?G@F6KK7IDKCDGGFKCJIIGKKCGJ?IE>@EHIIBJA>CGDI>BAIEBBIBGF@=D;CB@GEHFFGCJJFEJKDAF;F@IJ:DJ,J:KBKBJIHKHKCIKIHJJKK@>BDCGK5IHJKK/JHC3FHCBKEKIG3CJ=C:?J;CHEG1I>J@GKKCJIBGJF9JCGKBJ@99AJ&H7JFKGK=,3IKKDKGA@HCEHJG4KH>DH?KJIFJHJJIJFA5>>JKDJJIKIKDKKK?GDJKJKK4HDBBCD>8JJAJJJKFKJFBAFIIAJ?HJ<;$A;6C>D>@@AHDHA8;=EEGJIFHAFGDBE;C;IBHDEHHJ@5:;D?FBKJJGDEHD.HACJIIJKKK(GII7JKH5DEICFIFB7@DECCFJDD=?8AJJK*FFIIGIDGA;IKK@JFI:JGCG@BEGIKFKK1HHEFDEHKAJIJHH:@AFEGKI9AHGJ@JGKJJFCK8JIK>HAHHJ9HECIKDBHKJGKHGBEAKJGGDKKIHDJKIKDEKEIFCIJDIIG@KIDKKHJCBDG6JGCKHJKJIIAGFD2JCIFKJ6GFCJEEBECI3AJI?HIKBJJ@JIJGAKKJKFJF=9ABIKKEJJBKJCICEJB?8BH<;B@GIHGJH=A>,HGGJBIGJJDCICI=6I>BEJ7HH?G=?EGIJIG>JKJIIIKJJ?HKIKBIB=IGKKJ(IFFJ?HIAGA3BHDCEI;FGHICJJ>FIHDJK6HEIJHFC=CEEGCIH4IGHJKC>JJCKF?H=HGEKFKJIHIJGIK4GG?KIJ?HKKKBFIAFKIJKC2J271GAHCJIJHGGEKKHHKAK1JK@CBEEC@9DHDA?G@JIK9E>JKCK@DBHIADIK@CCDE<9BDF?>&3KJKK3;GKK*FKCC<@I7HCEGEHEEHCJIF.E7E@BIJI;=BBKJJ:FBIE@AD6BDHCDIA/AC@EEHEH>CAEGG(C@FG=EECIBF:DD2A:GB?<:=BE-DF91HKJK*5J9F4:A7I7G=E=CDE;FAFE?GJBHEJ5II;AG4HFH@ECG+DKBFEC@&EJ4KK:8C1GBI@FE.?IFGGAG2;87BF/HJDEIIFGCFHD-=IJICIHJF/EIEFJ>KHFIDHJJGJKKBGD>GGK=II9BHK.EIIFFEKKC@IIJ.J??KHKKDGBKJ>IJHKFEJH6JJ<&5718/71/31C98->922&4<'6)<43+//,74%)/,853)&,/*-')##"%#%%&('&(&'$' @rCer/1921/25_1650_CCS ATGGGGAGGTTCTCTTACATCGACCGCCTAAGAGTCGCGCTGTAAGAAGCAACACCTTCTCCTCCTTGTCTCCGCATCTGCTCTGCAGTCGCGAAGCAGCAACCATGCGTGAGTGCATCTCCATCCATGTTGGCAGGCTGGTGTCCAGATTGCATGCCTGCTGGAGCTCTACTGCCTGGAACACGGCATCCAGCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCGGGCCGTGTTTGTAGACTTGGAACCCACGGTCATTGATGAAGTTCGCACTGCACCTACCGCCAGCTCTTCCACCTGAGCAGTCATCACAGGCAAGGAAGATGCTGCAATAACTATGCCGAGGCACTACACATTGGCAAGAGATCATTGACCTTGTGTTGGACGAATTCGTAAGCTGGCTGACCAGTGCACCGGTCTTCAGGCTTCTTGGTTTTCCACAGTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCTGCTCATGGAACGTCTCTCGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTACCCAGCGCCCCAGGTTTCCACAGCTGTAGTTGAGCCTACAACTCCATCCTCACCACCCACACACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACATGAGGCCATCTATGACATCTGTCGTAGAAACCTTGATATTGAGCGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCTTCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCAGACCAACCTGGTGCCCTACCCCGCATCCACTTCCCCTGGCCACATACGCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACCATCCAGTTTGTGGATTGGTGCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCTGGCCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAGACATGGCTGCCCTTGAGAAGGATATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAAAGTTAAAATGTCACAAAGGTGCTGCTTTTACAGGGAAGCTTATTCTGTTTTAAACGTTGAAAAGTTGTGGTCTGCTCAGTTAATTTGTATGTAGCAGTGTATGCTCTTATATACAATTACTGACCTATGCTCTAAACATGATGCTTTGTTACAGACCCAAGCTGTCATTTCTGTGATGGGTTTTGAATAAAGTATTCCTG 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85,=;41065:8767;.6746:7+65/6597921.65781527/95/9565;4)4:.65,/0289466667390%2.499547/7:5656:7:*784349991738::71/149786:974:65(32-.(,,/%,'40469201.70)2)##+$.449:044-76,.1669948&304:4:9:9.:6872861&7,/904-745::7270767:::+402(5117-54755.526457333/1/26,8140:8;:-9803487558/::8322/72,67/-04)/#15-09399*8-977-784/,2.6*4'7879.5+20.014881-436'196%($-0&(*.59:6:75853'623)&813324.0&%).',30598993936.-37.,5%'24-1-,0,&$4-0&,0240.24)/283::49&1(/+1)3;9:-:3:808443+0%+-84939/,2.9647/03046'3/2206;77366652(71+037:8;35698;:626#-9143%//5410/355.654062,/'+*+.&1.73/7-'1:/:59507997'/6932:80-84*2)&./2.6.6122.8999978'1,(96/695864'-771.1+75.5/6/2505/3)-6242/:357+81-&.1426402)3&&3/-3)&.-7997;/0-23-279-*7886/9463,314.2395$,39-2'1/7243565688971746:69'45,3-97'(+%(693220(027+9243854.62.32*667/1,5+51-+748399-67631&364649:5.5814:-708547/23/112;:;38<66075:3<68,8>>8216/3/+#0058>2=,2235421;;8,#32767<4:79>,'#9<;5'5,400/896'%2377.578>40/:>::,2),'(04+;-30;9+7:,8=3>>;4:81<<=775*789.929:03/09<2777-6*8332?5?%59:975;95-16,93.4&3562:7;54370/5;9396:3;;5;47%/),,9,6(,:*97-&869::93,72?0>9+243;48;7+7868.47944:4+829::'-798;6;1847:31-1.<398:&;84+;;>1?2=9:28<54;46;>?97;9;&65862686<8=:6=86+;1(69*47315:58+;93=9-<424167$.8-87827511779:569477:420250/64.'/3-)1,0243983<3.21855$2(86$7-5;26<9=;:3;<32=;=6;8;;=:;3927?6;6;32/<56./8074352&457971=::?=?,:;93/*7:<7791(8,;>;0-$19483.8315.=7+86/103/1&$25)627317,;/2035,25168493620..91735;833--/'-(-014,3'+6-84344&665+6*344273503%569;7=7<5:.:>>/1-0==2866*<9/7347%97;-07::,:;%8311&67759.,(87806:,835*24-35025/733&,/-..625849157672.17966293,20.4843*.)/871/+'8513990%4&/'3.+32(232002).'/00))./-.%'*,1315(41%0-**.12$216 @rCer/1924/25_1393_CCS ATGGGGCTGGGGACACGGAGGTCGGCAGGCAGCACACGCAGGGACCTACGGGCAGCTGTTCCTTCCCCGCACTCGAGAATCCCCGGAGGCCCGGAGGCCTGCAGCAGGAGCGACCATGAAGAAGCTGATGGTGGTGCTGAGCCTGATCGCTTGCAGCCTGGGCAGAGGAGCAGAATAAGTTGGTGCATGGCGGACCCTGCGACAAGACATCTCACCCCTACCAAGCTGCTCTCTACACCTCCGGTCACTTGCTGTGTGGCGGGTCCTTATCCATCCACTGTGGGTCCTCACAGCTGCCCACTGCAAAAAACCGAATCTTCAGGTTTTCCTGGGGAAGCATAACCTTCGGCAAAGGGAGAGTTCCCAGGAGCAGAGTTCTGTTGTCCGGGCTGTGATCCACCCTGGCTACGATGCTGCCACCCACGACCAGGACATCATGCTGTTGCGCCTGGCACGCCCAGCCAAGCTCTCTGAACTCATCCAGCCCCTTCCCCTGGAGAGGGACTGCTCAGCCAACACCACCAGCTGCCACATCCTGGGCTGGGGCAAGACAGCAGATGGTGATTTCCCTGACACCATCCAGTGTGCATACATCCACCTGGTGCCCCGTGAGGAGTGTGAGCGTGCCTACCCTGGCCAGATCACCCAGAACATGTTGTGTGCCGGGGATGAGAAGTACGGGAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCGCTTGTATGTGGAGACCACCTCCGAGGCCTTGTGTCGTGGGGTAATATCCCCTGTGGATCAAAGGAGAAGCCAGGAGTCTATACCAACGTCTGCAGATACACGAACTGGATCCAAAAAACCATTCAGGCCAAGTGACCCTAACATGTGACATCCACCTCCCGACCTACCACCCCACTGGCTGGTTCCAGAACGACTCTCACCAAGACCTTGCCTCCCCTCCTGCCCAGCTCTGACCCTGATGCTTAATAAACGCAGTGACGTGAGGGCCCTGATTCTCCCTGGTTTTACCCCAGCTCCATCCTTGCATCACTGGGGAGGACTTGACGAGTGAGGACTTGGGCCTAGCTCTGACCCCCACGGCTAAGAGAATACAGGAAAATCCCTTCTAAGCATCTCCTCTCCCCGACCATTCCACACATTTGATTTCTTCCTGCAGAGGCCCGGCCGCGTGTCTGGAATCCCAGCTCTGCCGCTTACTATCTGTGTCCCCTTGGGATGTGCCTTCCTTCACTGTAGATTTCTGTAAAATGAAGCTAAGGATGACACAGTCTCCATAAGGCAGTGGCTGTGGGGAAGATTTAAGGTTTCACACCCATGACATACACAGGACAGCGCCTGGCCCGCCATGCACTCAGTAAAGAATGAATTTTATT + 8E=JIGCB(DEFCDFCAF5B?BAGHDFG7C?IIFJB?FBKJJ@J=DIBG;HDI-DDEIKGDIHF>:=C4?IHHFI7EH@HFAJFH2@EBDH4EIDJII@?EA:GA;C?GD&@EEGHEDIFJIGHA?IHH?BDJ:J>FBFCHB>G>DIF@HIHCH=IJJ?DKIDBKIJJKIIGAB@KJKHGID0GHEEJA?/ADJF?KHKJK4IKKFKI9EGGCJFHEH7KFICKJ3HG@KJ9JGCKIGGJ2FEAIKKEJKJI;HFJJIKCI;FIEJGIHGJFEIGGKKKJI@GKBG7I9CBCAJJIHJJGIEJKFJDG?EEIAJ?IIKKKDICEI3?FGFJ7IBAHJEHKJJDIJKCJIJ=BGKGDKKG5A>FJFHDKIEE@EKJKKCEEIHKF9FKI&KKJKKHKKBEJHGGHDEAEBJIJKFGKEDIK@AKDKGIBDJJGKJ8IKFKIJGJJE@KJBJADGDFKGBFKJABKA8@:JHA86KJ>;IFK0HAJCIKDHJDDGBGCG+EJKHKEJFGGA/GFGA:>JJ=KK@BGJHBGAJI@HHB8G?AKEF:BKKJKH5K-KKG@JBEF2<<=BE?FIK>KKKJGJ @rCer/1925/22_1817_CCS ATGGGGGAGCGAACAACGCCTGGTTCGAGAGCAGCTCGAGGTGTCCCTGGCCAGTGTCCTTCCACCTGTCCACAAATATGGGGAACATCTTCGCCAACCTCTTTCAAGGGCCTTTTTGGCAAAAAAGAAATGCGCATCCTCTATGGTGGGCCTGGATTGCTGCGGGAGACCACGATCCTGTACAAGCTTTAAGCTGGGTGAGATCGTGACCACCATTCCCACCATAGGCTTCAACGTGGAAACCGTGGAGTACAAGAACATCAGCTTCACTGTGTGGATGTGGGTGGCCAGGACAAGATCCGGCCCCTGTGGCGCCACTACTTCCAGAACACACAAGGCTTGATCTTCGTGGTGGACAGCAATGAAAGAGAGAGCGCGTGAACGAGGCCCTGAGGAGCTCATGAGAGCTGGCTCGAGGACGAGCTCCGGGATGCTGTCCTCCTGGTGTTCGCCAACAAGCAGGACCTCCCCAACGCCATGAATGCAGCTGAAGATCACAGACAACTGGGCTGCACTCCCTACGCCACAGGAACTGGTACATTCAGGCCACCTTGCGCCACCAGCGGTGACGGGCTCTATGAAGGACTGGACTGCTGTCCAATCAGCTCCGGAACCAGAAGTGAATGCGACCCCCTCCCTCTCACTCCTCTTGCCCTCTGCTTTACTCTCATGTGGCAAACGTGCGGCTCGTGGTGTGAGTGCCAGAAGCTGCCTCCGTGGTTTGGTCACCGTGTGCATCGCACCGTGCTGTAAATGTGCAGACGCAGCCTGCGGCCAGGCTTTTTATTTAATGTAAATAGTTTTTGTTTCCAATGAGGCATTTCTGGTACTCCTATGCAATATTACTCAGCTTTTTTTATGTAAAAAGAAAAATCAACTCACTGTTCAGTGCTGAGAGGTGATGTAGGCCCATGGGCACCTGGCCTCCAGGAGTCGCTGTGTTGGGAGAGCCGGGCATGCCTTGGCTTTAGAGCTGTGTTGAAATCCATTTTGGTGGTTGTTTTTAACCCAAACTCAGTGCATTTTTTAAAATAGTTAAGAATCCAAGTCAAGAACACTTTGAACACACAGAAGGAGACCCGCCTAGCATAGATTTGCAGTTATGGCCTGGATGCCGGTCACCAGCCCAGCTGTTCCCCTCAGGAACATGTGGTGGCGCAAAGACCGCGATCAATTCTGCATGTCATAGTAGAGATCCCCGCAACTCGCTTGTACTTGGGTCACCCTGCATCCATAGCCATGTGCTTGTCCCTGTGCTCCCACGGTTCCCAGGGCCAGGCTGGAGCCCACAGCCACCCCACTCTCCCGCAGGCCGCCCCACCACCTTCAGGCAGCCTATGGGACACAGGGCCCCATCTGTCCTCGGTCACCGTGTGGCCAGAGTGGGTCCGTCGTCCCCAACCTCGTGCTCGCTCAGACACTTTGGCAGGATGTCTGGGCCTCACCAGCAGGAGCGCGTGCAAGCCGGGCAGGCGGTCCACCTAGACCCACAGCCCCTTGGAGCACCCCACCTCTGTGTGTGATGTAGCTTTCTCTCCCTCAGCCTGCAAGGGTCCGATTTGCCATCGAAAAAGACAACCTCTACTTTTTTCTTTTGTATTTTGATAAACACTGAAGAAGCTGGAGCTGTTAAATTTATCTTGGGGAAACCTCAGAACTGGTCTATTGGTGTCGTGGAACCTCTTACTGCTTTCAATACACGATTAGTAATCAACTGTTTTGTATACTTGTTTTCAGTTTTCATTTCGACAAACAAGCACTGTAATTATAGCTATTAGAATAAAATCTCTTAACT 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%#"$#$$#"%$"#"#%%$%$##$!"%$"#"#$#""#$"%'(&(($(('#&#''(%&(%"%''&(()$&$%)%(%(((&(%'%(()%())()()(($'#("$#%%(%((()()$()('%)($(%%#&('&))(&)(%&$'%(#%'('$#$$&$(%(&#%$&#$#"%$%&$#'#&'&(%''('%(%(&%$&'')))((')(()(('%'''(')(%#$#(&)'(')($$&'$$&(())(($%"&$%'&#$%((()(%)#$(((%'#((%(((%&&%'%%(%%%&()$&$%(&(()(($%%%'()(&'))((('$($(()$$%%$$%()''&)('($($(()&()))'%'(&&(%($'(%#%##$%'$#$%#$$'%$$&"%'))())(&&(&'#$&(&)((()($%##"##$&()&##(%')&'(($%#%-'))*)*(%&)(),(-,'-,'*,**)+)*,+),,&))*$"%+'--&('($#(1/..'*.-+*/,'00+,-++(011//$.$...,,-.%%+.1*+,'(-110,.-/%%%(,'*'%*/+-.(,.+,%)'-.-110,,,.'-,.,-%00/+1..*&,-()-10-21,)$))&$).)+'.0,*1-.021212-,*10.0+..+,.-''.00-+.1111.(+0*(..(,)'+.%(.11-,-+1000-)**)&.-*1/.+%'-*)+-00,'-00..-(()*0'+)0*(,1.2....-*/%/-,2/&/12011-11/)110,-0+/*.0.,&0..+&%,*+/001-,-2(+0+1,2,,0/&+,.-,+0./1.0&$01)**$./00-&/-+/01010121-"/.,.',-/-0,21010+)*/-*/&*$)**-&..//./-$+(#&&*,()1/10-0,1-11,-.-*/.'-0(111/&(+0-0(++0)*0-01-0,0/,,)*+(,.2.-.11100.*,1+&&*)1-2..%''$+%,)))'+&-+.(,/-0/0(-,..1-,.1+++./.10+1/...1++&-$)-11/(0(//)1/$',0./-+'%0//+,*)//',/*0,1,+0000,21--(.,././.)0,/)-,-....-%,&)+/$#*'(&+-011*)&//'),/+0-+/'/+1-1--)*)/*.+,0.-+.-.&-./-*,/(2++.,00+,/-101,,%,,-)+.+0$$1-.12.0-%/112,0/,+.,0&)3.2020.-3221.42545/33*1'-)//$).26-3/.),%-.2341$*53140.52.-,0./.2.(111-)(,$&0435+126&0/*$33,02/6/0'221066422,032/426,12+,'1554101-24*112.#/.1546*12555105/*4.460-*-/%00%11024454,$302)2025(-,231*1/624-34-555221'+.3*451/3'1341)-5221/0*43,/22))4/5*-%..4135/.54)0-/1.0(+43*/1003+3.2405/36'22///,1*/,)13&,//)&(./3300'2123/&2,*34+1200(0-0102,45/3/-41335065535/&(((04)&232416%./1,252,553%)+535.4214.1,16-3'$%-.%-.11-.+1300//,4/3530.54400./%-.+33..*411452252660311,-25*14,)66)141024635+00'&)$5#*)(.5552626.4-,36,0,50)441.1/-/2111/4+12665302/44)2453,/..4+33&1/-0.,-351241652,/0%,2316301,*/.&2$(,)*130402*0263,224.122.3,4*0 @rCer/1926/296_57_CCS TTGAGCCCCTCAGACAGCCCCCTGCCCCGCAGGCCTGCTTCTCAGGGACCTCTGTGGGGGCCCGAGGCAGGCATGGAGTGAGACCCAGGAGCTGGACACTTCTCGGGAATGGCTTTTCCCAACCCCCAGCCCCCGCCCGGTGGTTCTTCCTGTTCTGTGACTGTGCATAGTGCCACCACAGCTTATGGCATCTCATTGAGGAAAAAGAAAACTGCACAATAAAACCAAGCCTCTGGAAT + ,)&.**&,%/,0,01110)+*').'++%111322.4.%0/++0/,,*)/$***+.*.10$++$'%0(*+-($'*/.(-2-(%(02+23-/+).5552011.+.)'&$.$,4(.232,+1)1*,122'/.1342&0.0)022401(02.5234666264,01)..104(121/1,*3-,)&"%-++,5,0*1232-1&./623440%+-15&0(4-33.&*374+21,)9:848::43(5 @rCer/1927/342_62_CCS CCCTTTCTTTTAATATATAAATTATGTATGGTGAAGTGGAGTGTAATGTGTAGGTCCCGTATTAATGCCTTGACGCCTTTGAAGCGCAGCCCCTGTGGCCCGCAGTCCCTGAGCCTGGCTGTTGTGTGTATTTATGCTCTCTTTGTCTGCCTGTTTCTAAGGAAATGCATGTGTGCCCTGAGCCGTGATGTCCTCCTGTCCGTGTCGCGAGCACAGGCATTTTTGTCTGTCTGTCCTCCCTGTGATTGGTCTGGCATTTCCGGTATTAAAATGATACAAT + *(#'&%(%&(%)())((+((,(*,,*(').)(-.---*(,++,'-*,+'+*+*,+--(&(%'#'*+,-,$"+-#+('&'&,.---*%,,-)'$,+&*(,)',++)'*,$'-)-.-*---,,+(()'&&+$*-($')&)--)%+&&(*)+.--,+,',,.--(,*$-*)&,,'*)++,&++-*+)*+--*$$+&&*()$*-+---,*-*(,))%&,-)'(*,,*%)((*$%,+''-+#'($)(#**,),)+(,,&'((),,)-(,-.)++,&(''$)+*)) @rCer/1928/25_1822_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACC + ;<*=:;:9>4<;>@A?:C;<@96>@69889<<>;A;=<@A@::8@<><98A9@8)=9:0<3048?A@A7<;55;C=A??60678:;.=2>>;47/3:8/2%3;3>2*572/76@775;9:4<>590228898;<=0=<61<;-456(4,37:94=<==<=;>.<9<;?6=+21939=762%+-40311-8568823648483343=>57<+6<;:>>9@.96;@:1;;-66.566598?@594:9?64/?BC=/@;5=>8+@897.84;=>.7;>8.<3DAAD;=@A@:*/;=@>;:@4@?/B>C;FA8CDBE@<-@??>>B<<88E??F?EHBF+73;;<7@7<=.@<=6=DFFCCC7ADCF>A@><1B@BAH>B;BBA9<@>A@C>:D@;D<:FD:=?;HHIJC<9>FBG@GGCIH@FHF@H:AE>BBF<9:,9B?AFIEJAD7GEKGI@C?C+68?B8A:;EB@CCFC=HCDJED8??>BHIH8KG?AC@CCIGDDFBABC<9;@GDIE<22EEDEJIHIGGACFABIGGBKGK@IKFKI9HEHJHAH>II9JKJKKHDAJJJKEG:FCFKDJKEJFFHJHKFKGHI2DEHH3@J:4KIJKIHC?DDI>K3K=FJKEI=EJFEDD@FJJIIJKJJBIHKAKAKGF>JKB@FH4KF@CEDADFHH=FBF>F@KE?0FCDE?>ACDJFGGIJICFEHB=51GIGGGABFIEDHE;DH@?:GK8@HE@JEDEI?E=@G<76=EE8?AA4D>E>=A8DGDGJ7HH=AACF=D-AAD=8?CGDI3JH@8GGDGHEH>8FGGK@JI8@=CJEJFB@KI?GJ>BD8HAFF==GEJJFJI?AEFHICE;J>E?7A5D=:FI=IFGCIIGA8HG@GIG;IH>EIJJDGH:KFIABFEFHJHFG=AACB?9EFFFCHK?KGG)EIGHHGH@.ECDI;FEJDI$FKHEFDBAFCEGC?KFCFEGGFA;BGJ.EIDCEECI/BF0@7@5H;B9@EJBHI+FHFFJDIEH8BKJEGGH968FJHIHKIHJDABHCEKDBEIEGIACC?HD<>@BCAF*EADGGDC?G;;E3>GCI?E9CEEG;F?F@FAE>8FH6ABDBAF7F=B?FGEJ>>I>E98A@?ACD>GGB?>F?FEHIDEE7G?@B6C?>=<FCDG9H=HHAC:G<=ACCEDDD?GCIIHGEI>G@AFHHIDCB3:E7@D?)FFHHBE@BFG>GDI?EBFEJACG%=97798=9D@?;5DED?2FC?D@DHDDHFA4;E9D.CB@2E>?(6-:HGHFF,IHHEAGI@GBDG8HHIDFH;HGIC,FGG?GA>D@HDF3EB?HF7DIH=HIEF?=DFHF?HCCAH<:@FHHGIFCD3DE5GHII;<=AA8EG>DC5GEEGBD=H>CCF @rCer/1930/1727_61_CCS ATGGGGCCCCCTGCCTGTCCGCCATGTTTTCAGGCCGGGTCTGGCTTGGTCTTCCCCATAAGGAAATGGCCGGGGAGCTCAGGGGACCCAGGCGCCGTCGCTGCGGCGGAGCCTGGGCTGACCAGCCAGGACAGCGGGGTAAACCCGAACAATTCTGCGCGAGGTAGGGAGGCCATGGCGTCCGGCAGTAACTGGCTATCCGGGGTGAATGTCGTGCTGGTGATGGCCTACGGGAGCCTGTGTTTTGCTACTGCTATTTATTTTTGTGAAGAGGCAAATCATGCGCTTTGCAATGAAATCTCGAAGGGGACCTCATGTCCCTGTGGGACACAATGCCCCAAGGACTTGAAAGAAGAGATTGATATTCGACTCTCCAGGGTCAGGATATCAAGTATGAGCCTCAGCTCCTTGCAGATGATGATGCTAGACTGCTACAACTGGAAACCCAGGGAAATCAAAGTTGCTACAACTATCTGTATAGGATGAAAGCTCTGGATTGCCATTCGTACCTCTGAAATCCCATTTCATTCTGAAGGCCGGCATCCCCGTTCCTTAATGGGCAAGAATTTCCGCTCCTACCTGCTAGATCTGCGAAACACTAGTACACCTTTCAAGGGTGTACGCAAAGCCCTCATCGATACCCTATTGGATGGCTATGAGACAGCCCGCTATGGACAGGGGTCTTTGGCCAGAATGAGTACCTACGCTATCAAGAGGCCCTGAGTGAGCTGGCGACTGTGGTTAAAGCACGAATTGGGAGCTCTCAGCGACACCACCAGTCAGCAGCCAAAGACCTAACTCAGTCCCTGAGGGTCTCCCCAACAACCATCCAGGTGACATACCTCCCTCAAGTCAGAAGAGTAAACGTGCCAAGCACTTCCTTGAATTGAAGAGCTTTAAGGGATAACTATAACACATTGGAGAGTACTCTGTGATGGAGCTGAAGGACTCTTGCCGTAGATGAAGCCAGTCAGTTGCAGTGTGCAAGACAGGCTGCTTGCCGGGCTGCCCTGGGGACATCTGACTCAGCAGGCCCAGACTGTATCCATCGAAGTTCCCGTTGTATCCAGAGTTCTTAGAGCTTGTGTCTAAAGGGTAATTCCCCAACCTTTTCTTATGGGCATTTTTAGAACATTGGCTAAGACTATTTTCCCCCAGTAGCACTTTTTCTGGATTTGCATTCAGGTGATTATTCTTAATGTTCTGTCAAAGCTTCTTAAAAATCTTCACTTGGTTTCAAGCCAGTTCACCTTCCCTGTTCCAGGTTGTATTTAATTCAAAGGTCGAGAGTTGGAGAGATGTTCTCCATATCCTATACCTTTGTACACAGTGAATGGGAACTGTTTGGGTTTAGGGCGTCTTAGAGTTTGATTGAATGGAAAAAGACAGGAAGACTGAGGTGGGAGGTCAAGTGGGGAAGTTGGTGAATGTGGAATAACTTACCCTTGTGCTCCACTAAACCAGATGTGTTGCAGCTCTTCTCTGACAATGCAAGGATCTACTTTAATTCCACACTCTCATGAATAAATTGAATAAAAGAGAATGTTTTGGCACCCTGACATAATCTGCCAGGCTATGTGACAGTAGGAAGGAATGATTTCCCCTAACAAGCAATTGCACTGGTCTGACTTTATAAATTATTTAATAAAATGAACTATTATCAAAT + 544,.0354'%09:9;>>;9>=:><;;8<659:8;9==5<=7:.820784>?1693'324/61:0*0:56+660+4$62$/,56,110'1/+2-0-*10541255.03.536222/-02032.125550152104430'5660*.,45002250,4/04+,%,+(*+#&'((.)).,*/./+')&+...*)03321152632.(%.,4.52.0/520./,125120410.-0*-4614,$+()))#+%-(#(354-10+/3022+4241..36,.&/%.0),0534,5,,2624523'441/14,1/(&*40552051322--*03(/+.&..533)'#'$)&.4203/3*.2140/00)&+,3.)53)/2,)2100&#&02)*-11-66421$,0+16.3-3-04131.531'3010(-(.-1',+0.20.),.)0/0+-12#%,#310/*3+2063112/51..0.331,1/441,)0231-1.,&*250)3,+*$460150402551541-(&'126266355.22,+.0'41//0*-++,.0&,3(0(0,((.54.0-.,2(.3+2-//).-+,2-442+--..35645662664-.(001*1/51/5-2,4.)34,0,233-.-0)526410*.'/,+015.5.0.+%46.,00*(&./.2'0564,/#.41,3+)*..4*1),'()////6.4&($'/5210-+163.*435/.522,-22+464134654.'.#0-1/)22--,.,2)/.041,1100()-..,,0/-51**./13/*/2..1*-0*-3404/-*/,.1%/4--1'2**,&1(,%+2-211(%-(+*/-&.10360&24&4500/,3666524.303/-(+4014.2220/-5--*51/4//1*/2+.//+2*.2&*1(.20/2611(,.3)50,3/01*$./10.*4050/1*0)0*3/140+61*-)0,22.4-2)0/.--%'&&-&-)&//+*.-,/1+/34).*121/04*00'15324'350-,--*/)(%&'00-2.&-(/5-0.103,/)/11&(%(()(*+/'&)(%.'#,/.0,.**&/+-1530/)')-*++'),))(''(/0,1))&*%0(*/2%3/&--,604/.+(+'/-.*.-3+1,+1*('2.-2453,)*/,&*,2/%.1-3303&/4,.553*0343054.&1(%2*-,+4/0/)5/3$+)4.-.0-+.,&5-33344'4+601*%))+1//0/*%.-+++0-3))*-+*/(11+.,))-&'$$#)-.+*%(&(-+)'''#(*&**0..)*)().,0$&$$*).&$%&%'-'*1.-20*11+#)&"%,**&'*%*-,/,-.*.'*12+/*++*,*0+((-(*()$()/$--&)*&0.,*),-/%+*,*"%%0,&)(*0)&#)%*+(%**+1.)211,*((,0-&(-,20-+,.'0,,1...21./*/021,*%%,).+-)-+//().+-)+//&,%&$*+)+)$"&'*)''+,-(.-.')&(*'%,)/11/-,+%$'-())'/'*%%+'*/-.-1.+1,/0,01&((,-%&%1,,)$%))),/&&%-*%+$)+-0/+-00,-0,-0+00,/,,',''&(#(.'/.*.-+&*%+0*1.1,--,(.,,+''**,&0.-00*0-*/.,,*.0-/.1+'(1101+/ @rCer/1934/1947_53_CCS ATGGGAGTCTCAGTCGCCGCCGCCAGCTCGCGCATCTTGTTCTTCTGCCGCTCAACTGTCTTAGTCCTCCGCCGGTCGCAATGGAAGAAGAGATCGCCGCCCTCGTCATTGACAATGGCTCCGGCATGTGCAAAGCTGGCTTTGCTGGGGACGATGCACCCCGAGCCGTGTTTCCCTCCATCGTCGGGCGCCCCCGACACCAGGGCGTGATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGTGACGAGGCCCAGAGCAAGCGCGGCATCTTGACCCTGAAGTACCCTATTGAGCATGGCATTGTCACCAACTGGGACGACATGGAGAAAATCTGGCACCATACTTTCTACAATGAGTGCGCGTGGCCCCAGAGGAGCACCCGGTGCTGCTGACCGAGGCCCCTCTGAACCCTAAGGCCAACAGAGAGAAGATGACTCAGATTATGTTTGAGACCTTCAACACCCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGGCGCACCACTGGCATTGTCATGGACTCTGCGACGGGGTCCCCACACGGTGCCCATCTACGAAGGGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGCTGACTACTCATGAAGATCCTCACCGAGCGTGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATTGTGCGCGACATCAAGGAGAAGCTGTGCTACGTCGCCCTGGACTTCGAGCAGGAGATGGCCACGCCGCATCCTCCTCTTCCCTGGAGAAGAGCTACGAGCTGCTGATGGCCAGGTCATCACCATCGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCGTCTTTCCGTGGGCATGGATCTTGTGGCATCCATGGACCACCTTCAATCCATCATGAGTGTGACGTGGACATCCGCAAAGACCTGTATGCAACACGGTGCTGTCTGGGGTCACCACCATGTACCCAGGCATTGCCGACAGGATGCAGAAGGAGATTTCACCGCCCTGCACCAGCACCATGAAGATCAAGATCATCGCACCCCCAGAGCGCAAGTACTCAGTGTGGATCGGTGGCTCCATCTTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCTCCATCGTCCATCGCAAATGCTTCTAAATGGACTGAGCAGATGCGTACATTTGCTGCATGGGTTAATTCAGAAGTATAAATTTGCCCTTGGCAAATGCATACCCTCATGCTAGCCTCACGAAACTGGAATAAGCCTTTGAAAAGAAATTGTCCTTGAATGCTTGTATCTGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACCGTGTATTTCAAGTTAACTGTTCCCCTTGGTGTTTGTTTAATACCCTGTACATATCTTGAGTTCAACCTTAGTACATGTGGCTTGGTCGTTTCGTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGTGAGTCTGCCATGGCCAGCAGTCCCGATCTGTGCAGGTATCATGTGTCAGGGCTTGAGTGTTCTGGGATTTCTCTAGAGGCTGGCAAGGGCTCCTGAACCAGTTTCTGCCTGCCAGTCTGTCAGGGTTGGAAAGTCCAAGCCATAGGACCAGTTTTCTTAAGCTGACGTTTTCTGCCAGAACACCGTGGGCTGTTACTTGCCTTGAGTTGGAAGCGGTTTGCATTTACACCTGTAAATGTATTCATCCTTTTAATTTATGTAAGGTTTTTTGTACGCAATTCTTTAAGAGATGACAACAAATTTTGGTTTTCTACTGTTATGTGAGAACATTAGGCCCAGCAACACGTCATTGTGTAAGGAAAAATAAAAGTGCTGCC + +***&&&+(,,'(),,-+*)&(----*$(-----)$.,--*(-%'%+.,++),+)(,()++**,-+**+'()%(''--,.---)(*,,&,--,**#**,.-+-,*,,--+(),-(*.--,*'**(,%)+*$)-)),-.-,--*-)*&'&$,--+((,(+,+%,-+--()(,+(*,'(-+'+'(,--+)-),,,,&,,,,-&*))'$'(''*+(+--+(+*--+-()-,(-+(+)+(,*--+,%%$+((,,+-+()-*,+,%*+))-)(((+,(,*.,+),+',('(,%+)-(+)++)'**)+,)--)(-**),,*-,-,+*'*)(&,)-*-$(,+-,)')),,*-,-***$(-,---#(-,(',%+,-,-(--,,&------),-+-,),'&,*.)*-,(,,+$(,(),'-.,')(-+.,*---)%,-+.*(,*-+),-----))**,,$',*+*+,'+,($+%'&%%-,-(+'++--))(*,(,&,(,)'-$*)+-+**),&)+(*-,.*&%#'%%%('-%')+-&*-(())())))))('%$(()('&'#'$$(%(%$')('())(%$%%&('&#()(&(((((&$())))())')(&%(%($%$%$$)$$%#()((%(%)'))%(%%&#'&('%'$#())))))&%(%%('%&$&(())))&()'()'&)))((%(&$(()('$'%'(((%))()&$''%()))'')()'&''%)'%%'(())()))'%&)&(()()%%$%'&())('&%'()()('#'(()(%$##'(%(()&%(&))''$)()))('%%$'$%'%%())()%%$()')(('$#'%')))())(#%$$&)(((($(%('%)()%()())))))()(%()())'((#$%#())()(&)(##&)''&%%()))%%(%&'&%&&())'&"$&%%%((%'$%()('%&(')'#((()()'&$#'((%(&()'$#(&#%%)(('()&&&((#$$#(')()&())(&(%$%(%&(')%&)())())('(&%(&%&)%$%%$""'()(&'%$&#&&(#'$$#$##$')($%$('&%'%(&((%('((((#%$&'(%()'#'%$()()))&)()))))(($%#(&'$#)%)('$())&('$&#$)&)')((#()()($')'')%(''(%'%()((('%')(''%()(''#))%&%&))))))())))(((%(%'&&())&())))())))'%%'%((&#"%'&'$('%'%(((($)%&$(%$'(&%%(('&%%)&&&'(%)(%$&%(%&(((%%#$#%%((&(%(')()))(%))(('(%)'$$%()(((%(($'%'((%)()))%'%()(#$''%()'())(((%()(%(()))(&(#((('(#')()((&%((($&'#($$$$"'(%'($()'('%)&'%()(((($)')(('('%())('%(%&)'%&((())))()%%$(()')&&#(###)+'&&,)+)(-'),)(,--)))++&*&%'*),)(()*+++*,)&*(*,(+(+(+((+(+(&&)&$)*)'(+,)"#+,-*,,),-,($#&%-)''%%%*,*)#)*$++)+,+(,*+-(&*&+&(,,.+----*)**',)&*,+)-,,--,,,)))'+--*--,(-),)..,--*,+(-.,,(,-),&(,--),(,(--*)(,(-)*+'-,,+&%,',,,--',.,*$,---+-----*----(-,*)--.,,'+,&,--.-*).,&-+,(,-).,.,,),-,,)-(-,*--*---.-*,%&*('&#)-*,----*--*+',)&)*--.-*+,,&*+$*()-+*-,.--..)*#('(+-))++'++-*,-,&,,--,&---&-,,(,,,'%+++%$"*%'(&-.''++,&---,'+,,*--,-.-.,,,+,%*(((%()'(',,( @rCer/1935/1949_53_CCS ATGGGAGTCCCGGCTGCGGCACCTGGGAGAAGGCGGACTGTGTAAGGGGGCCTGTGACCCAGCGTGCCGTGGCCTCGGGGAGTGGGAAGTGGAGGCAGGAGCCCTCCTTACACTTCGCCATGAGTTTCCTGATCGACTCCAGCATCATGATTACCTCCCAGATACTATTTTTTGGATTTGGGTGGCTTTTCTTCATGCGCCAATTGTTTAAAGACTATGAGATACGTCAGTATGTTGTACAGGTGATCTTCTCTGTGACATTTGCATTTTCTTGCACCATGTTTGAGCTCATCATCTTTGAAATCTTAGGAGTATTGAATAGCAGCTCACGTTATTTTCACTGGAAAATGAACCTGTGTGTAATTCTGCTGATCCTGGTTTTCATGGTGCCTTTTTACATTGGCTATTTTATTGTGAGCAACATCCGACTATTGCATAAACACGACTGCTTTTTTCCTGTCTCTTATGGCTGACTTTTATGTATTTCTTCTGGAAACTAGGAGATCCCTTTCCCATTCTCAGCCCAAAACATGGGATCTTATCCATAGAACAGCTCATCAGCCGGGTTGGTGTGATTGGAGTGACTCTCATGGCCCTCCTTTCTGGATTTGTGCTGTCAACTGCCCATACACTTACATGTCTTACTTCCTCAGGAACGTGACTGACACAGATATTCTAGCCCTGGAACGGCGACTGCTCCAAACCATGGATATGATCATAAGCAAAAAAGAAAAGGATGGCAATGGCACGGAGAACAATGTTCCAGAAAGGGGAAGTGCATAACAAACCATCAGGTTTCTGGGGAATGATAAAAAGTGTTACCACTTCAGCACCAGGAAGTGAAAATCTTACTCTTATTCAACAGGAAGTGGATGCTTGGAAGAACTAAGCAGGCAGCTTTTTCTGGAAACAGCTGATCTGTATGCTACCAAGGAGAGAATAGAATACTCCAAAACTTTCAAGGGGAAATACTTTAATTTTTCTTGGTTACTTTTTCTCTATTTACTGTGTTTGGAAAATTTTCATGGTACCATCAATATTGTTTTTTGATCGAGTTGGGAAACGGATCCTGTCAAAGAGGCATTGAGATCACTGTGAATTATCTGGGAATCCAATTTGATGTGAAGTTTTGGTCCAACACATTTCCTTCATTCTTGTTGGAATAATCATCGTTACATCCATCAGAGGACTGCTGATCACTCTTACCAAGTTCTTTTATGCCATCTCTAGCAGTAAGTCCTCCAATGTCATTGTCCTGCTGTTAGCACAGATAATGGGCATGTACTTTGTCTCCTCTGTGCTGCTGATCCGAATGAGTATGCCTCTAGAATACCGCACCATCATCACTGAAGTCCTTGGAGAACTGCAGTTCAACTTCTATCACCGTTGGTTTGATGTGATCTTCCTGGTCAGCGCTCTCTCTAGCATACTTTTCCTCTATTTGGCTCACAAACAGGCACCAGAGAAGCATATGGCACCTTGAACTTAAGCCTACTACAGACTATTAGAGCCAGTGGTTTCAAAAATTTAATCTAAGAGGGGGAAAAAATGGAACCAGGGCCTGACGTTTTTATAAACACAAAATGCTGTGGTAGCATTTTTCACCTCATAGCATACTGTTTCCCGGTCGGGTGATACTATGACCATGATAGCATCAGCCAGAACATGAGAGAAGAAGTAACTCAAGACAGTACTCAGCAGAGAGCGTCCCGTGTGGATTTGAGGCTGGTGCAAAGGCGGAGAGGAGCCAAGAAACTAAAGGGAAAAAATACACTGGAACTCTGGGGCAAGAGATATCTATGGTAGCTGGGCCAAACACATAGGATTTCCGTTTTAAGGTTCACGTGGAGAAGGTTATAGCTTTCCCTTGAGATTGACTCATTAAAATCAGAGATT + ,/00%,)011*1+,.332,2563436134:66251+-1-.364:8;89:14(88+*342'6975)7:54876:4:7690/565;;9:0//:5:;9687559;;96:37&3529854446813/158+2.439595467;3+984*45.50/+///0/4+67:4:76552559/75:;;9:308;6:838676)7744979-6196-48(/4,7::2-97:5::255845:6846;6626:82/239357585987/6594;:5755799,3/-67855,.46:39:69:56631/1/2%556146664624.-$--.3.4.565/254152611005*465163555))15+.+235441+652*10666622424533891/39;89796//./*,476)8./*+/46%62021/,/1,(305,,,0/1263)44060/.#115605266466064452+34-.3/656543/122)0266662014.1.55614*5,'*.45154162445/14.42240604255*1336621(20-2,65)03110153541334116561,244400524624.255154.54,0..,22),0-12+*/-+/20'$1052653606546625261626/22662.46/123,2.264645-01242551//000/(53602-5555*04/3*1132640523).+56123534001/,33,4656661*(0.-$4646263/*6411&(.%.,/0,021--/%-6644'056614662632.*266626662666466644/'/0156.642562661612*-.)*+/533304122.($.363204366-325/020)6424.35.145-3),,.(&...1#'+/($0$.46/.444226266033/0.4154+512,341264.230344-4+4,6045436+203-&,.4360532/56613-%/52/-/)),,+/&1,-240%21.1146414/12$10+.55634333,164/1/+24&545.1.).#*21*43202441./22131$).,21,3403.-22'*.+/26/552/%*-.3611563)134121623416062304335)510346533-51*41563556616/15)0-31-(10(5/63543526.4511,421/(--2/655,32.12+04666564/.44005.%3465165330/'33-.221+2241210-12165446654352(.3263*46156665+/1/4016151400.15/-&-53.530242456,53555*5542520)44631-2540333/+%&),.)524121/0.1-42-1))11453+5660655616-0211+,5/562,4225*421/5.2.00.*.-)$,.*.13*)5,(44,0*15..*/-..+))++-,(),1021-1/+&40+22110&5/56664632105/15-&)-110-/2/6520+04614234+2324//0,,45225,.254/21451)0-/..1)22*.10,*$.1%$/554++11.+(*%00000'00,-&/..12,2.-,0.0..-,$--0+&(%/,/1,11-,//.-1--,0+10/+0,0,0110*11,',.1.00)*'%/-1011-1/1.10)1/'/0110-&+',1/1..021-,,++*,*00-'1/,1*-.20..-1*.1111-%)11,./-.+,.1+,.221,*.-.(+(.&0,,--0201,,02,.+.1.1.0.&/,.*++-,0*1000*)-,01111)1111-11-/((+0-.0.&/.*,,101/(/---200.1100-&-,00,00/-112100((1//./-&/,010-.000)+$)02+0*/**,,,&/.(+'&*&/*--53/00*..20055+56220203) @rCer/1936/0_1387_CCS TGCTAAAATGGTGATGTGTGCATTTCTATTCTTCATGAAGCCTGGGAAAGATAAGTATGGTTATGAAAGCCAAAGAAACGCTGGCTCCCTATCCACACAGTGGAAACCATCATGATTAGTGTCATTTCTATGCTGGCAGACCCTAATGGAGACTCACCTGCTAATGTTGATGCTGCGAAAAGAATGGAGGGAAGATAGAAATGGGAGAAATTTAAAAGAAAAGTTGCCCGCTTTGTAAGAAAAAGCCAAGAGACTGGCTTTTGAGTGACATTTATTTAGCAGCTAGTAACTTCACTTATTTCAGGGTCTCCAATTGAGAAACATGGCATCTGTTTTCCTGCACTCTACCCACCTATTGCTGGACCTTCTGTTGTACAAGTTGGCAAACACTGGCTGGAACTGGGCTGCGCAATAAAAACATGCCAGTATCAATGCTGACAAGAGCCTAACAAGTGCCAACTTACAGAATGATTACGTATTTGGAATTCTAATGAACTGTTTTAACCTTCAGGAAGAATTGTAAAGACCTGTACATAGCACAACATGATCCGGATAATATATAATACTGTTCATGGTACATCCACAATACACCTTGTACCAAATAATGCTTTCTTGTAGTAGAATAAGAATCGTGTAAATTCTAAAAGATTTTAGCAGGTTTTCTTTCCTATTCATTGTTTCTTATCAGTTTAAAAGGATTCCTTTAAGCATGTCAGATGAAAAGCAATTAGGATTAAAAGTTCCATTTAATTTCCCTTAAACCATTGAGGCTCATTAAACTCTTTTCACTTACTAAACTTTTGTATCTTCTTTGTTTTGACACACTCCCCTTTGCTTTTGTCTCTTATCTGCCAGAATGTTCTCAAATGATTTAGTTCCAATACTGAAATACTTAATGAGCAATTACTTGATTTTTAATGATGACTTCGAAGGAGTCATCACTAGGTGCTTGTCCTTTTTCTATTCTAGTTGCACCACCTCTTGGATTGGATATAGCAATAACATTTATTGGCTGTTGTGAGCTCTTGATCCCAGTCATTACCCCCCGAGAACTAAAAATAGATGGTTCTTAATTCAACTTACAGAAAAATTTCCCCCAAACAATAGCAAATCTGACTTTTCCCCTTCAGTTGCCCGGTAGTAAGGTGGATAAACGAAGCATGCACAGCTACAGGCTTTCTACCTAACTTCTGGGTTTGCTATTACAAATACTATTTACTCTCATACCCTTCTCCTTAGTCCTTCATATTTCTTTGCCTCTATTCTTCTATACTGCAGATTTTTCTCAACCTATTGTTAAAGAAATTGCGATGTATATTTTCATGTAATTTGATTTTGGAATTCTGTCACCTTATGTAGTGAGTTCTTCCAAAATATAATTTTTTTT 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S&"#"$'%##&&'&#$&$$$$'')$#&'(((%'((&##$()-+%')$)(&*-,(,+*&'('*(&%$,)$&*%$,+$(),(&,,*(**--*%*(*'(%(&*+).(01/2100/*023/1*'01//16023,/025022452$+34/1./64//014/,2412153/(+/*01&(-.53$,(#,+./063/52,/,-1*(/45*$++01%,+%&"%++*+&-*+++-.)..*($"&.*)0)%/*).--(',+--,-*"'*(.10,+/0-+-,*('/%+-,,,)%$&-,*&+-,)/)+&.)'))(-')((**"$&*''%-%%0/-)'(*%'"&*,(+.0),$-0./'+,*%1--.-.+12-,.(-%%,)-)01120',*-1+%+*/,),1/11/(.*,,1/2..&',$#($"$(--#&')+&$)('+*(%(+/'/*-/+/1112110(2*,01,*-++-,(+/.2,001$--+.021+)-,%(&(/02(+*%(*--)+**-)-1,**--.0011.,2++-,-10(0)(.+.(1.0./(..,-0'200'+--0./011/20/+')#(&$(&,--,/+$'.))*)+1--#)')&--0#*-/,*-)//.,00/1*0.,-0/+('(+/&+,.1102--0.1---,+-//$.*,+/+100.10+$+/6,1/..54600-403133(220.66:.01'80*/53/11.257-694953028'500-/0-695483913969202//+-0&,39*11814,4611:59+64&1-(.1)$.1%*999/78+$&.512/,4143.+,4,0&771+-604%**/2,))60+1)3/20',$0.2+.::6,6725-&),'%(779404-.5:4/'02,)(/0062../55272;6.-159432546826454680/040657.967*58632533::7840-8322856330,0,4:3*,.*.,$3552522553440&5/(,+%)-03)8,695542615)3*5103.3(8282'522.376/0033012569859458/:67719665-*-2/-.3103,%**(%&+*.2*.-+..6/3*0&'**/.+407.$,0646%011+$0)$3,-*&.-.+.,.435981//+)8+2)0+472(0.4-(2-,30-63-*31920$+1/.,1686+/44845334583*,-12620742-16;3479-435*2.)75/,6&4494/.02565,453273.35745/3/,,)42857/01/30-2.--('+3(121.76504)86.5.2/3-01,3*53'301-,)-%77740435%$&$'.'(*&-074,&2.031%/)//14/5.-.261-,505+.*,'.,-')130,'%#+,/.4.(0/,10)-(/(1*$'./+.#)01111- @rCer/1939/25_1691_CCS ATGGGGGGGGTCTGTGTAGCCGGGAACGCTCGCGCGGTTGCCAGAGAAAGCCCCGGACGTGACGGATTTGCGCGACCCCAAGCAGCCCGTCCTTCCCCCTCCATCCGTCATTCCCCTGCGCTGTCTTTCCTCACCCTTCCCCCTCCCCCGTGGGTTCCAGTCTTGGGAGAAGTAAACAGCGGGTGGAGCGAGGCCTACGGACCCAGGCCAGGCGGGAGCATGCTGGGCTCTGGGGCAGCGGCTCCCCGCGGCGTGGGTCCTACTCCTGTTACCTTTCCTGCCGCTGCTGCTGCTTGCAGTCCCCGCGCCCCACCGCGCGTCCTACAAGCCGGTCATCGTGGTGCATGGGCTCTTCGACAGCTCGTACAGCTTCCGCCACCTGCTGGAATACATCAATGAGGGGGCCTTGTGTGCCGGGCTCTGCTTTCTGTCATGGATGATCACAATGTGGATTCTTTCATCTCCCTCTCCTCTCCACAGATGGGACAGTATGGAGACACGGACTACTTGAAGTGGCTGTTCCCCACCTCCATGCGGTCTAACCTCTATCGGATCTGCTATAGCCCCTGGGGCCAGGAATTCTCCATCTGCAACTACTGCATGATCCCCACCACGATGACTTGTACCTCAATGCCAGCAGCTTCCTAGCCCTGATCAATGGGGAAAGAGACCATCCCAATGCCACAGTATGGCGGAAGAACTTTCTTCGTGTGGGCCACCTGGTGCTGATTGGGGGCCCTGATGATGGTGTTATTACTCCCTGGCAGTCCAGCTTCTTTGGTTTCTATGATGCAAATGAGACGGTCCTGGAGATGGAGGAGCAACTGGTTTATCTGCGGGATTCTTTTGGGTTGAAGACTCTATTGGCCCGGGGGGCCATAGTGAGGTGTCCGATGGCCGGGATCTCCCACACAGCCTGGCACTCCAACCGTACCCTTTATGAGACCTGCATTGAACCTTGGCTCTCCTGAGGATATATTCAGGGGTCCCCAGGAACTCCTCAGTCCAGAGACCAAGTGGTGGCCTTGGAAAGCAGATGTCAGGCTTTGGTGTGCCTGTGACCACCTCATTGCTCCCATATTATCCCCCACCAACCTGGCCTCCCAGAACCCCCTTCCTCTGCTCCTCCGTGAATGACAAGTCCAGGCCTCCCCTACCTCATGTCTTCTCATTTGGGGGATTGCTCCGTGCTCTCCCTTTCTCTCAAGGCCGAAGTTGGGAATTGAGAAACCATGTTTTTAACTTGTGGCTGCTTTTGCTGCTGCTGCTCCTCCGTATCTGGCTGTATGGGAGGAGAACCCACGCCTGCCCACCACAGGGGTCTCCTTCCAGGCCACTCAGGACATTTTTAGCTTCTCTTCTCCCCATGTTCCCTTTTTTCTCTGAAGTCCCCTGTCATCAGCCCTCCTGACCCCTAAGAGAGATGACCCATGAGAGTGGGGTTCTGAGGCTCCCCTATGGGGACAGTTCCATTTTTGAAGTGTCAGTGTTGGGGAATATCTGTGGCCTATGAGGCCCATCTCAGGTTTGGGGATCCCCCAGTCCCTATGATCAGTGTTGGAGTACCCCCCTGGGAGAGCCCAGTTTCTTTGAGGCCCCAGGCCCTCTTTTAACTACCCTTGAATGGGTGTAACCCCTGTATTTATGGAAATAAAGTTCCATTTCC 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A8'=??>=;89299947;@B?=ACBBABA,7=:==7;7;A;>7,09644<5BA?>?C=D7B9?@B=1CC?9>DA@4AD=9CCD1A.C@@:@A?=:<91;>8B>>C;=C@E1EC??D2BCBB>A:B?;FB<;A?>9B:A?AD<A@A9>=64<<@C=D6?B@DB;A@@=,BA>DE2A:9?=8D<.97;:54:89=96<=/6>==C5:3?:1>C;DCC;=>BC>>;;>??BB8E474=AEEGABD=>>6A68AB>?;?7CD8FDED=F?=?C>5;9?18D@E@?CE>AAD=?D=9=B=>9?>=?9?=E:CDBGC+;5)4>=?DAAGA;FBF708896A9@GB;EBB>EBBD;?=GCECD3::>:)=6BDE:2C>BCGB;E>A5B?>1B3DBB=?EB:B@B?9@B;99E87.81??=@AB?DD?BD9EACB@=8@AC;CGE(B>>;:;>?;@;CC+B=>3B>=CFD>E<=CC@>=EEADG=?DB@@AFB+B>9BD?EC@5<4=<>C6B<6CA=@AA?@3@67CECB?CC>?;>BG3AAB9C@DECC=?BE@CE:==DE;F?D?B/EB;JG:+41A2I<-CECFA;E4C?C15B?B?CF@IGDEBAEDA0?BAH=9GBI<4ECCHE7H>EGCGFG@G?FDH?HH:FGGC77IF=*?@FGGEGFC@AH4GDFEI>B4D>E8BBFJFDHAAFAI?E?CG?ID;7EFH5GCECF>>'B73AEE??>CBDHD1=EC.FAA;ABCCGFA8AAAAEEGG>@6BAECAF?H;H@*DEFHIBDHCGFCGH1GGBBF>>H?DADDGHDE?GIE8HGCA0FBBGGHCHD?:IHCHI;=C::@HEHCI6>DHBE?H@EGGICA>IHIDGFD86CID)FCHHC3D>BIICGHFE7G3CDCFGBBDG?BB>H>F=D/BHCH4GC3CDHEEHI>IH8HEG@>,IIGFG:D5FFAEFE1BHFIGI=DAFDEBA4=6DGEE8JGGBB<,GJHHG9FEHI?E7ID@E?9IE@EHHHHH6EGEF@H6EHB,BEEBIEIB?HGEF @rCer/1942/25_2208_CCS ATGGGGAGGGGCAGCCGGGAACCATCCTCCCAAGCCCAGAGGCAGGACTTCGCAGCAGGATGGGGTGGAGAGCCCGCGGGAGTGACCCCACGGGAGTGAACACCCCCACACTCCCACCATCGCCGGCTGGCCCCGGAGCGGGAGGCCCGCAGCCAGATCTTCAGCCAGGGGACCACGATTCGCCAGGGCGCTGGGGGTTTGCTGCCAGGACCGTGCTGCACCAGGGCCCTGAGCCGTAGGGGAATGGGGGAGGGGTGGGAGATCCCGGCACCAAACCCTTCTGCGCTGCTCGCTCTGGTGTATCCTACATGCAGGGATGACTGGGCTTTCCCTAAGACTCAGGGGAAGGATGGAGCTGTAGGGCTCTTTTAAGTAAGCTGAAGCTCTCGAAAGGAGGAGGGCACCAAAAGTAGTGGAGCTCAGGTACGTCAACCTAGTTGCAGTGGCCAGAGATGCATTAAATTTCTAGATCCCTGTATATAGTTGTTGACATATGCACTAGAAGCTATAATCACATAGAATTCTATGTATATCCTCCCACACCCTGGGTAGCTACTGACTGAAGGGGTCAAGCAAGGGCTATTTGCTGTCCCCCGAAGTACACCTGGCCGGAAGGGCACAAACACGGCTTCTTAAATCACTCACTTTCTCCTGTTCCCCTCCTATTTCTGAAATATAAGTTTATGACGTTCTTTCACAAAAGAGTATAAGCATTCTTAGACTGTTGATGTGGCTGTGGAAAGCCTTAGGAGAAGTAGAAGCAATTTAGGGGGGTGGGGAATGTACTCATCCTCTCTTTCCATCCTAGTGCCCCACCAAAGAGGCTTGTTGCAGCCCTCAGTATCTGAATATGGGCCAGGAGGAAGGAAGGGAAAGAGCAATGCTGCTGTGCTTCAATCCTGGCCTTCCCCTCACAGAATTCTTTTAGGAAGAGCAAGCTTTGTAAGTAGAGTGACTGGCAAGTGTTTTTATCTTTTTTTTTTTTTTTCCTGCTCCTCAAAATGTTGTCTTGTTCCGGCAATCACTTTTGCCTTCCCTCTTTCCTGAGCCTGTAGTGACAAAGCCCTGCGATTTGAGATGAAATCTGTTGTGACCCCAGAGCTTTGATCACACACACATCCTCTGGTTTTGAGTTATACTACAGAATCAGAAAGGCTGGAAGGTGGGCTTCACTGAAACTCAGGATTGTGCTTTGAGAGCCAGCTAATAGACTAGCCAAGGGAAGGTTAAATTGGCTGTCTTTACCTTTCCTGAGAAGCCCTACATAAATGCAGCCTGTAATTGTATAAAGGAGATGAGAAACATCAAGAGAAATATGTGGACATGTGTGTAGCTCTGGGGTAGCAAGAACTAGACTTCGTCAATTTGGATTCCATTTCCTTCTGCCACTTGCTTTTAGGCAATTGAGTGTGGGTAGTGATGAGATATCAAACCCCTTAGTGTTTCCTTTTGGGAAATGAGGCACTATTTTTTTAAAAAAAGACAACTTACCCACCTGAGTCCTGAAACAGTTTGTCTCTCCAGTTTTCTGGCCTATACTCTGGTTAGCTCTGAGCCAAGTTTACAGGACAGCAGCCTTGCTTTAAGCCATGTCCTGTTGTGGGCACGATAATAGCAACTGAGCTGTCACAGCCTACCAGCAGGCTGGTAGCACCTCCAGGGTCTCTTGGCTATAGCAGATTTCTTAGCAGCTGACTCGGACTTCAGTCATTGGGAAGCCTGTGAGGCCTTTACATTTTTGGTGTGAGACAGGGAAGAAACATAAAATGCCACTTTATAACTTCAATAATAGCCTGTAATTTATATTTACTGTGTGAATTTTAGTCCTATATTTTAATAATTTGTAAATTGATCTCTTATTCCAAGAATCCTTTGAACTTATAGAACATCTGGGAGTCCACTTCCCTGTCCTCTTCCTGATCCCTGCTTTCTGGACTGTTTAAATCCTCTTTGGGATGGATCAGAGAGTCTAGAGAGGCCACTCATAGTTCCAGCTGCTGGCCTCCTGACTCTCCAAAGCCTTCACTGGAATTGGGACATTTGCTCCAGCCCTAGCTGTGAACATGACCAGAGACATTATTTATAATTCAGCCATTTAAGATATACCTGTACTCAAAAAGTCCTGTATATTTTTTAAAAGTTTTATTTTTCAGGTGAACAAAAATACATCCTAAGAACTCTGC 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rCer/1943/2175_55_CCS ATGGGTCACAGACCAGTATCACCAGTCCTTCCTCACTGTTGTCCTCAACCGGCTAGGATACGCCCACTGGATTGGACTGTTCACCACAGATAATGGTCTTAATTTTGACTGGTCTGATGGCACCAAATCCTCTTTCACTTTTTGGAAAGACGAGGAGTCCTCCCTCCATGGTGACTGCGTTTTTGCCGACACCAACGGACGCTGGCATAGCACAGCCTGTGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCCCCTGAAACAAGACCATCTGAACACCCAGAGTTGTGCTCCGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTCCTAGACAGTATGAGTTTTGAGGCTGCTCATGAATTTTTGCAAAAAGGAAGGTTCTAATCTTTTAAACAATCAAGGATGAGGCTGAAAATGCATTTCTCCTAGAAGAGCTGTTTGCTTTTGGTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAATGAAACCATAAAGTGGTTTGATGGAACTCCCACAGACCAGTCAAACTGGGGCATTCGGAAGCCAGACACAGACTACTTCAAGCCCCATCATTGTGTTGCCCTGAGGATCCCGGAAGGATTATGGCAGCTATCCCCGTGTCAAGAAAAAAAGGGCTTTATATGTAAAATGAAGGCAGATATTCGCACTGCAGAGGAGCTGCCAGAAAAAGGACCAAGTCACAGCATCATCCCTCTTGTGGTAGTCCTGACACTCATAGTCACTGTGGCCATTTGCACTCTTTCCTTCTGCATCTACAAGCAAAACGGTGGTTTCTTCGGGAGACTTGCAGGGTTTCAGAATCCTTACTATCCTGCAACCAACTTTAGTACGGTACATTTAGAAGAAAATATTCTCATTTTCTGATCTTGAGAAGAGTGACCAATAATAATGAGGTCAGAGAATGTCCCAGCCACCAGGAGCACTTTGCTGTAATTTAGAACAAATTAAGGAAAAAAAATCATTCAAGTGCTGTTTTCTTTCACACCATGAAGTAAGCATGATGGACCAAAGTTATCTCATTTAAGATATTATCATCCATTTTTTGTAATTATGAACAGCAATATCATCTTTTTTCCTTCAAAAAAAGAAAAAGACACCCTGATCTATGCTATTTTCAGCTTGTTTCCTGTGCTTCTATTTATTAATGGAAATTGATTTTTCAAGATTAATGTAAAATGTGTTTATGTTTCTCCCATTAAGTCTCTTATTTATATTAGATTCAATGTATATGTTCTGGATATTTTTCAAATAAATATATTTTTAATATAATACAGCAATTTGCAAATTGTTAAAGGACCATTTGTAATGTTTTCTCCTGGCCCCCCCAGCCCTGAAACTGTAACTTTATTATTGTCTTCGCACAGTGGTTTGTGAATTAACTTGAGCTCCTTGAGTTCCTACTTCTAAGAAATTATTTAAACTTTACTCTTTATCTTCTTAGTATACAGAGCTTGGTAGGAGCTGGAAACCCGACTCACAGATTTAGGAAACAGTGAGTTCTTGTCCCTGTAGACATCAGAACTGTGGGGAGGGAGAGATAGAGAACCAGAAGGCAGTTGGCTGTAAGTATTTGGCTTTATTTCTGAGTTCTCTATTCTGTTCCTTTGGTCTATTCCTTTGTTCCTCTATTCCTTTGACTATTTTTATACCAGTACCATGCTGTTTTGGTGACTATGGCCTTATAGTATAGTTTTGAAGTCAGATAATGTGATGCTTCCAGATTTGTTGTTTTTGCTTAGTCTTGCTTTGGCTCTGTGGGTTCTTTTTTGGTTCCATACGAATTTTAGGATTTTTTTTCTAGTTCTGTGAAGAATGATGGTAGCATTTTGATGGAAATGCATTGAATTTTTAGATTGCTTTTGGCAGTATGGTCATTTTCACAATATTAATTCTACCTATCCATGAACATGGTATGTGTTCCCAGTCATTTGTGTCATGTATGCTTTCTTTCAGCAGTGTTTTGTAGCTTTCCTTGTAGAGGTCTTTCACCTCCTTGGTTAGGTATATTCCTAAACATTTTATTCCTCCTTGTAAATTAATAAACTGACATTGTGATGTCC 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@rCer/1944/2222_57_CCS GGGGCGCTGCGCGCGGCTACGGGCGGTCAGGCGGATACATCTGGAAGTTCGTGTGGGGCTGGGTCCCGGAGTGGGAGACGTGGAGTGCAGGTAATGCATGTCCATGGTACACAATTCACAAGGTTTGTAGACAAGAAAGATGTGAGTTCCTTTTGTTCTCTGCCTGTGGCCTCCCTGCCCACACAGGACTCTAGGTGGAATGTAGCAAACCATCCACAGCCATGTACTACCCCTCAACCAGCCAGTTTGGAGCGGCAGTGTCTGGGGAGCCGAGCCCCCTTCTCGCTGCGGTGAGCCGGACTGAGCGCGCACTGCGCAGACTCCCGCTGCAGTGGCGGGCTCCCGTAGCCCGCCCTCCTCCTCCCACCCTGTTCAGCCTGTCCGGGCAGAAGCTGGGCCCGCGAGGTAGCAGCAGACGCCTGAGAGCGAGACGAGGCCCTCAGGGTTTGGAGACCCTGACACACCACTTCTCACCTGGGCTCTGCATATCCCCAGCCTTGAGGAAGATGAAGCTAAACTGATGTACAGGAGCTGAAGGTGCTGCAGAGGAGCCGCCAACGAGCTGCCATGAATGAGATTGAGCGTGGAAGCTGCGGAAAAGAAGCCGCTGGTCTGCTGTCCTCATTCTGGCGGTTGTGGCTTCGGAGCCTGATGACTCAGCTGTTTCTATGGAATACGCGACTTGCATCTCTTTGGACCCAACCAGCGCCAGCCCCTGCTATGACCTTGCGAAGCAGTGCTGGTGGAAAGCATTCCTGAGGCCTGGACTTCCCAATGCCTCCAGGGAACCCTTCACCAGCCAGGCCTGGCTGGGCCTGCTCGCCGGTGCGCACAGCAGCCTGACATCGCCTCTTCTACTGGACCTCACCAACAATGACACCCACACGCAGGAGCCTCTGCCAGCAGGTGAGGAGGTCCTCCGGCAGCTGCAGACCCTGGCACCCAAGGGCGTGAATGTCGCATCGCTGTGAGCAAGCCCAACGGCCCAGCCACAGACGACCTGCAGGCCTGCTGCAGAGTGGTGCCAGGTCCGCATGGTGACATGCAGAAGCTGACCCATGGCGTCCTGCATACAAGTTCTGGTGGTGGACCAGACCACTTCTACCTGGCAGTGCCAACATGGACTGGCGTTCACTGACCAGTCAAGAGCTGGGCGTGGTCATGTACAACTGCAGCTGCCTGCTCGAGACCTGACCAAATCTTTGAGGCTACTGGTTCCTGGCCAGGCAGGCAGCTCATCCATCAACTTGCCCGGTTCTATGACACCGCTATAACCAAGAGACACCAATGGAATCTGCCTCAATGAACCCTGCTCTGGCCTACTGGCGAGTGCGCCCCCACCCTGTGTCCAAGTGGCGCACTCCAGACCTGAAGGCTCTACTCAACGTGGTGGACAACGCGCGGAGTTTCATCTACGTCGCAGTCATGAACTACCTGCCACTCTGGAGTTCTCCCACCTCACAGTTCTGGCCTGCCATTGACGATGGGCTGCGACGGGCCGCCTATGAGCGTGCGTCAAGTGCGCCTGCTCGTCAGCTGCTGGGACACTCGGAGCCATCCATGCGGGCCTTCTGCTCTCCCTGGCTGCCCTGCGTGACAACCATACCCATCCGACATCCAGGTGAAACTCTTTGTGTCCCGCGGATGAGGCCCAGGCTCGAATCCGTATGCCGTGTCAACCACAACAAGTACATGGTGACTGAACGCGCCACTACATCGAACCTCCAACTGTCGGCAACTACTTCACGAGACGCGGCACCTCGCTGCTGTGATGCAGAACGGAGGGCAGTCTACGGAGCCAGCTGGAGGCCATTTTCTGAGGACTGGGACTCCCTTACAGCATGACTTGATGCCTCAGCCACGTGGCAATGCCTGCGCCTGCTCTGAGCCGGTCCAGCGACAGGCCGAGGCCTGCTAGGCCCCACAGACCCAGATGCTCTGGTCACGTCCCTGTCCCGTGCCCCGCTTCTGTCTGCCCATTGTGCTCCTCAGCTCTCTCCCTGCTCTCCACCTCTACCTCTGCCCCACCGGTCTGACGCTGTGGCCCAGACCCAGCAGAGCTGGGGAGGGATCAGCCCCAAAGAAGTGGGGTGCATGCTGGCCGGCCCCTGGCCACCCCCACTTTCCAGGGCAAAAAGGCCAGGTGATAAGTAAATAACTTGTCT + 652&,+%05*1/551)551202*+1+2532,23$&,0144.44'6/,203./--4::,75.1'368(6,76;=7+:2979?;0>6@9.22'8,3,9F;84>F7HAI5D?BG6D(07FBBJ@B.JC?C>&8E<;@>;(:><*HHI8?F;96-7EJ7C9?>*<,=>@%<8BE-C5B@6A$:@+A:4&7A=8GD,6+@@A68-6A=(::=<=FB?;9G:A8GJ7J7;7D>52DB@%E'C-DB,GBDF3EA@?CF@H@=G3@BCF?+.-EECEC'4A>ED>D<@>A=?I:(58@B2<2=A7=@C)*AFG-CD:+=E-+=>#30&@6(>B>)(?>$>AI6>B8E3D@??&FC(CDAG4&'4D;+41%)*-4A7GEH;=A?90>1)B/A@482*?7=A;&=@=,CD-9DBHB6DC09(8:==C$B>@?;C4>&@'13CEGD?/DD=$4BE=G@AE?CAC>%>CF4FAD7<&B79AC>HBA(9CG0@<<97<9A2+/#>3:81G;E<0;()=@CCGF-C7D7GG5G>3@>;8=6<29D0=,@E?>AG>1A%+<46/>C,E>.D5:@8+A?4BA'?)>.GE@>46-@IC9A<;GI8D<676/6.-@E(0A@7B??:=72CBJB=E.BE7$F5A3D8)/D.<)>6:'A:BCC4?AA$.4G?<8)2G7*6+;?B)>D)IA&B?&A'@4ABFEA2<%=?D=ABEE,9E558@>*A9FHD@;B8DB@&>?B8%2:A5C;B?:C3DC=CD='CF,9BED)J>?A)<5>>G>>28%>&A@=4>68<>:/3F8?<;&IH.A=7:?C(==)GEID2(@$AE@DB?4<9/F?43;?(;G.BD.CC?A<(,$4?BA8JG:@EAFH?BGF*CIA$-9EE)GHG>H@&>>)F:CB>$A=+@<.;F0HHBE5H@D738DE,BI.AD6B;G)H+0=<>4BG>GCIGK@KJJJK?<(A-AJKF0EAECIK,FEGG2GIIJDKHKKGJE8KGKIJHK5A,CJKBKDKH,GIJH<>&9C>KK(JHD*2D@KKJ7KF8,IG0<%E?)BFG(AH:IJ:HGJ&JKIK6$G@(E2AEBII@C@FEBC?%E@>*E@GBIG4F=7JBA*ACB=I@/<69F2GJHIF'>80:=G@AG->@??1D@5@BG:DE;B>=&>/CI/FIA4?IE@JBAHC9CJKD@H<@GJH-A$A:ICG5B@E;ADA3A;@?68#>(B<$HIJE?HCE3>J)/HC:?F9E4AII6FCHJ8&471HBD'4E=+KKICI6EJ+GI>HHFHDA;H-C?FB/>0<<9EFC.C.95I56G8--:A;85.>2ACHC=51?47/%6(=:9D?6/@9E4GC7<3=?-8A:0:D;34G0JF?G<-<5=8#>=$;CI8IE>C96G1(EIEEECD<;+<=>&4>CD;72<5;9(D=HFGFG9>A;5#$()).<1DB@GAB)<5%-;)@CIGIBFE0F0D@:B3DG@$8BAE3B$CFC(F,E.FD=8#CHF4EFB?EID7;:8.;H=>=8)CDC1)::?%::5?@-D?C?<8-.4GAE1FB?7AH?2@C@G?/&;?>CCCA+?7+C=HFE*ABEFFFHC*>B.9$12=)E=36657HIHCF5@=E'HFCD7DBB'EI38;12AFDF6=6;A><98;/4)-%BGJ'4>44*4;?>A&,,@C5H>BA.B9A<.7@?B@=7734669:8>7=:6578??=<:897870>:25?(<><@<:@A;>9/7<:=:3:8662/3874<096::-843278>3/9(8.8;<1;3@<=;>;/:3>>99?<:>@@:4<=:7<+83,<:5,;3'048-8/6??;,0:;69:1=)@B686*7722@97@499?=>/<97=58A55;--4099)24<=;:98;6+>;=>@-A;==?98=;>:=.4.?1*9=>>=A446<7?4?A.;649>:;/=<8==?9<:7:8-954-:931@<>=<9:9::6=43;;83*04A>?A89(>407=806;<<4492.//6'6;349;7/98063:67-($'0,0#/149.>?:?83=C/B=;@;,71.<073.77:9=4;;B>>>:2;1;53759AB1<7<94:8=A=0?93=C:7=6=?84;;686B;@?5+;7186543A@,=9/;@9<@A@0=9>=9?;65:1448584:4?:6?3==?B=:@8:98)2=<256?=A?==1<::8.=A+8>=?A5:=<98B;<.=<>(<9=75>C=9'?;;=>;;:-6A6<:23>=73=;?;3;>:1;2>389?98>37=8;>A<9AAA?/<:7@0????>9:'9+::749=C@A:;;;A:=<56418@4?8>BA8:54'6=6::*:9?=;=(?>>@7@>?9;3><2:9>=1<=A;;::>7B@;>2:686?6:;@<@?6&0<A:@9?;99:>'=;3:49=@<@AA67,5><;<>;1.=;45>7>B;A@BB<<=A=A1:;B=8<;>>,?88083<7=B7>56@@??;84@:?@;??3>@=>>1:895>>=<6>9=?;@><+65718@@?=9:931A>A=>8?9<:2:B<86:504>9:;:AAFB>@?@B=A9B5D8A-AD:?A====<<74;<809#@<8878478/,98@<45=??AD<@7=>BA=;CC@B?A6D>8A>=A?;1>1=>@;@;:2EEG@4A=B;5>3@D;F><:<8=='>?:;;@%<9;?><:5+',0==730>6A=9=32:263@=7;:3;6<7<<:=CC?AA?9A<@E=AC:>E>@5@E?B48?@3A:B=?;AA:EC?D@?EFC?9:=ABE=E@=D@<6;EF<9?B@DDGAC@@D9?6<6ABFC?>FE=BE@7>B<@BA?A8@@2C>A?CC>6A6?>0D<9BAE?F@BE@>C0<;<;=?09369,;@E=99?D?C99?5BB>:?;7<=BB;B:;B=C?FB;7>AD)FB;72=@;?BAA@B=8<:2B?4BA<;<;<7;:6??:DDBDB<>:>@>C97A=C@DDA7BD>:A@8?;EEEE=EED>AG<@8BC@>@??AB>AABCE=>GB?G=C<:A7??988>6518CA8B/>B?>@B@>;3>9=A;8:9=86==1:/>5?DB?BA>A;C>A57@>BAC<;3587:@?B8B;:A6680:=A8?=7D5><=C@C4>A;@@21=58=>6:;@4=764868,=.;.>8-@?;>;>&:=<61::3:A27:959<86&<=<21<7<2::?==B=;>(><>7>=B:<<-?>?B@:973=;?2<7@3@=B:<3@=8DBC@AB@B<:<@FABB>CD9DC=B4@A;A/=BCCEA<='BC@=?9;869C9EC;=A3CCB?@698:A;<9:=?1A.703(9593?99<@=;BA5BD/>9@D>@A,;9@<3?;?@@B9?/>BBC:739@?73:B@75=42A9.;57:+@(: @rCer/1946/2081_61_CCS TTGTAGTTGCCCGGACTAGGAGCTTAAGTGAAGAGGGACGCCTTATTCGGTGGAAATCAGCCGTAGCCATGAGCTTCTGCCGCGGCTAGCCCTAGAGTACGGAGCAGGCGGACTTTTCGATTCCCCCCCGCCAGGTGGCGGGGCCTACTAGGCTCCGGGCATCCCGGTCTCAAGTAGGCTCATCTGCCGGCAAGGCGCCCCAACGCGGGAGGCGCCATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTGAGCCGAGCCGGAGGAAGAGGAGGCGGTGGCCCCTACATCTGGGCCCGCTTTAGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGCCCGGCCTTGCTGCCTCGCCCCCTCAGATGCTGGCCCAGCGTTTCCCCCGCCGCTGTTGCTTCCCCACCCACCGCAGACCCCAGGCTTCAGCTCCTCCCCCTTGCCTTCGGCTGGGAGGCTTCCCCCACCTCCGGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGACTGGGATTGGGTTGCCCTCGCCCCGAGGCCCTGGCTCAGTCTGCCCCTCCAATTGGCGGTGCCGGCCCCCGCTGGGGCTTCCCAAGCCAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGCCGGAGTTGCATAAGGGAGATTCAGATTCTGAGGAAGATGAACCCACAAAGAAGAAAACTATCCTTCAGGGATCCGGCGAGGGGACTGGTTTGTCTGCCTTGCTTCCCCAACCTAAAAACCTGACTGTGAAAGAGACTAACAGGTTGCTCCTGCCCCATGCCTTCTCCCGCAAACCCTCGGATGGCTCCCTGATACTAAGCCCTCCAGACTGGCTTCTAAGACCAAGACTTCCTCTCTTGCCCTGTTGTGGGCACCACAACCACCACTCCGTCGCCCTCTGCTATCAAGGCTGCTGCCAAGAGTGCTGCCCTGCAGGTGACAAAGCAGATCACGCAGGAGGAAGACGACAGTGATGAGGAAGTAGCCCCGAAAACTTTTTCTCCCTCCCTGAAAAGGCCGACCACCTGGAGTTGAGCCATACCCTTACCCCATCCCACTGTCCTGAAGAGCTGCCTCCAGGCACGGAACCAGAGCCGGCTTTCCAGGATGATGCAGCCAATGCCCCCTTGAATTCAAGATGGCAGCAGGCTCAAGTGGGGCCCCTTGGATGCCTAAGCCTGGGGATGACTACAGCTACAATCAGTTTTCCACGTATGGCGATGCCAATGCTGCTGGTGCTTATTATCAGGATTATTACAGTGGTGGCTACTATCCTGCACAGGACCCGGCCCTGGTCCCACCCCAGGAAATTGCCCCAGATGCCTCCTTCATCGATGACGAAGCATTTAAGCGGCTGCAGGGCAAGAGAAACCGAGGGAGAGAAGAAATCAACTTTGTGGAGATTAAAGGTGATGACCAGCTCAGTGGGGCCAGCAATGGATGACTAAGTCATTGACAGAAGAGAAAACCATGAAGTCATTCAGCAAAAAGAAAGGTGAGCAGCCAACAGGCCAGCAGCGGCGGAAAGCACCAGATCACATATCTTATTCATCAGGCCAAGGAGCGGGAGCTGGAACTGAAGAACACCTGGTCGGAGAACAAGCTCAGCCGCCGTCAGACCAAGCCAAATATGGATTCTAGGGCTCTGGAACTGATGGCTCCAGGATCTCCTGCCAGCCCAGCTGGCCTGGCCCCAGCTTCACCTCTGGGACCCCAGCAGCTGCTCTAAGCCCAGGATCTCTTTCCCCAAGGACCAGCCCTCGCCTCTGCGAGAATGAACATATTTGATAGATTTTTCTTAACAAGTTAGAAAATTCAGCTCCTGTCTGTCCTGGAGCTAGCAAAGACTTGTGTGATGCCTCTGAAGGGGCTCTGAGTTCTGGGATGGGAGTTTTGCTCCCTGTCAGGTGTGATGAAATGTTGAACCTCCCCACCACCACTTTTTTTTTTTTTTTAAACCAGGGATGTCTGTTGAAATAAAACATTCAGTCT + 62565,5155+&3'114382918964.:::;30/89(307=0:39?:8;022,;>:>;)23*:=89>1A@<:1>?=9>>;,87;2:983?7);8?<19<=B919CBG??:%CA>@=%C@1<7A7##:5.7;&AA?1.%5DB>(>-??@?992'85,4?';37;@$12=4B8=72C;80%>??=?<@F6A+9>4F$:??F9)>$234@>8BA3DCC79A9:9>5B24BEAD9AA@;0C+@>>EDA>=;(H:59C267,BE7>E0FCF4AC(AA=B&=767<);*/B;;6:7:>->C>B@C8@1BD3FI2F;B@93155;;-5'<1887%=>7HE>E?=:7>D*5C@DA@43<@A$DD&8@DBE;C>?:6;9%33B39C7BE?1;9CD5A=899$*=112:>;&B:>A(BB@<$(>?I9DE1>=6AADD+:I:>C(F@,=7CC16I@D7C?>,9?C5B?FBDD9,A7/ED8@DG@FFCD'8A7<>E>FJGE*FHBHG6D9B;'FD+7@3B6=+9A%@F=G4F;>@DJ/C<>@JFFFDGHH3D@DGG=EDCIIHA8<6BGIGCHCFBG;DF=?:@G8@<<6J=A<;:>B=?>9)8ID?,F@?DB=)>@;B;=D5EGF:==FA%<@BBAGHJ9ABG(CI5FHAEFD1?JC=EI@@7A3A>96383@=E>BEBDB@D.8DEAD?CD0>AJCHHG@A)C?%=<=A4@DADGD)BEFFE=GD)>:A?ACFEFB?&B8<7>@EGGH?HEE9FFAB7=:8EBAE0HJG13=@ED:*D=E;8.=-1E:D==>;==.FA?9;68228=&B7@;;:&?EC4A@1::7<.=;;07;86A=>3?@C=C?>=/A=;<6=%>:9,A;83>:9>?BE*EEF/D>F.?>;C8DE>AGBBC->3DA;-A9;.B:==7A'C.C=@<7?78$49;B9?@7@@A@B49>>@A@=:2B7<47;A?DF2G=>=8?,9,4;B<*;E;A=CB1>6<7EDE@B88<8FE?C?;B79E@BD?6G@>>:BC@@D:@+@@;8>>7@?=99=<)?>B=?62/)+@3A>=9,48&@);;=8;@7)68>ABA=EAA7.7$=A;B==>%@A95@=B6?B;A8;4CFBC>8>B?9BD0D-B@@@9>&BE@9A<7=/??@9;:5;=;>D4D9BACFG6B%;A;@=?D5>?-<>+B=>B?BDBCA>;BB>3A@1>0G9AD<=AE?1B>:CA=C>A<@E:?AC=C=7?C9?F:57A<0CA3DB=C@76==6,AADDD8?0A9EFAEIC??GF9GGBCA@HI8@C@EI@H=EG?EFHB6:A':;-GHGCJ?;88*DE7;(EFC2?=HDCC;A<=%?B?C:F>C68=<>B*@A7>6CBEB=D:CBF@A9=B=;'BD9H>>>9DC7<@E-?7D/6?&=A@A&EFHG@?>CA=,E><:5?EB8>A5=>ICJ7HBD9:DCC@FHD?>E>?7;;?5C?>>829EE:>>A1A=;E0FADJ)?BB88-36>4=-?:@AFF9A<6CFGCCA&C@CA?3*:(2;C<,C?1@A/A887A?:6BCB@?BAC(;D5H;HJEABI@/4==D9IDE;?9A<1=FGCB?A>>A @rCer/1947/24_1811_CCS ATGGGGAGCGGCCGCCGAGCGGGAGCGGGTGCGGGTGCGGGTGCGGGCGCACCGGCCATCACCGCGCGGCCGCGCAGCGGACACCGTGCTCACCGGCCTGCGGCGCCCCGCCACCGGGCGGACCGCCGAACCGAGGCATGTCCCATGAAAAGAGTTTTTTGGTGTCTGGGGACAACTATCCTCCCCCAACCCTGGATATCCGGGGGGCCCCAGCACCCATGCCCCCTATGCTCAGCCTCCCTACCCTGGGGCCCCTACCCGCAGCCCCTTTCCAGCCCTCACCCTACGGTCAGCCAGGGTACCCCCATGGCCCCAGCCCTACCCCCAAGGGGGCTACCCACAGGGCCCTACCCCCAAGGGCCTACCCACAGGGCCCTACCCACAAGAGGGCTACCCACAGGCCCCTACCCCCAAGGGGGCTACCCCCAGGGGCCATATCCCCAGAGCCCCTTTCCCCCAACCCCTATGGACAGCCACAGGCCTTCCCAGGACAAGACCCTGACTCACCCCAGCATGGAAACTACCAGAGGAGGGTCCCCCATCCTACTATGACAACCAGGACTTCCCTGCCACCGACTGGGATGACAAGAGCATCCGACAGGCCTTCATCCGCAAGGTGTTCCTGGTGCTGACCCTGCAGCTGTCGGTGACCCTGTCCACGGTGTCTGTGTTCACTTTTGTTGGGGAGGTGAAGGGCTTTGTCCGGAGAACGTCTGGACCTACTATGTCTCCTATGCTGTCTTCTTCATCTCCTCATCGTCCTCAGCTGTTGTGGGGACTTCCGGCGAAAGCACCCCTGGAACCTTGTTGCACTGTCGGTCCTGACCGCCAGCCTGTCGTACATGGTGGGGATGATCGCCAGCTTCTACAACACCGAGGCAGTCATCAATGGCCGTGGGCATCACCACAGCCGTCTGCTTCACGGTCGTCATCTTCTCCATGCAGACCCGCTACGACTTCACCTCGTGCATGGGTGTGCTCCTGGTGAGCATGGTGGTGCTCTTCATCTTCGCCATCCTCTGCATCTTCATCCGGAACCGCATCCTGGAGATTGTGTACGCCTCGCTGGGCGCTCTGCTCTTCACCTGCTTCCTGGCAGTGGACACCCAGCTGCTGTTGGGGAACAAGCAGCTGTCCCTGAGCCCGGAAGAGTACGTGTTTGCCGCGCTGAACCTGTACACAGACATCATCAACATCTTCCTGTACATCCTCACCATCATTGGCCGCGCCAAGGAGTAGCCCAGCTCCAGCTCTCTTGCCCGCTCAGGTGGCATGGCTGGCCTGGACCCTGCCCCTGGCACGGCAGTGCCAGCTGTCCTTCCCCTCTCTCTTGTCCCCAGGCACAGCCTGGGGCAGAGGACGCCCTCTCCAACCCTCCATATGTACACTGCAGATACTTCTGTTTGGACCCCCTGTGGCCACAGCATGGCCCTTTAGTCCTCCGCCCCGCCAAGGGCAACAAGGCCACGTTTCTGTGCCACTCCTGTCTACTCATTGTTGCATGAGCCCTGTCTGCCAGCCCACCCAGGGACTGGGGGCAGCACCAGGTCCCGGGGAGAGGGATTGAGCCAAGAGGTGAGGGTGCACGTCTTCCCTCCTGTCCAGCTCCCCAGCCTGGCGTAGAGCACCCCTCCCCCCACCCTGGAGTGCTGCCTCTGGGGACATGCGGAGTGGGGTCTTATCCCTGTGCTGAGCCCTGAGGGCAGAGAGGACGCATGTTTCAGGGGAGGGGCAGCCTTCCTCTCAATCTGCTGTCAGTGAAATTCCAATAAATGGGATTTGCTCTC + 42,510'+036)14/55/--*,-/.1120555061',.-10114)012401560625502.0522.3/*+415655,.0605/0+/%124/*/1)3*3000.4/10024516+0.&65/13*.145660-#100)/$-/+5*54.53%0335+0#02/,..35505,&/342+14-/.1**0$.431+.'-./.4/2,..-%4302/*545/,#-)3.-11)5543/4625087502'&/223&323/5:4'97.%*+/(/3,(&47-06-155956;413'52342415985269/5::8&1-5679.:*95525$3-)-%,,61%)+365:9.5%3+,1116/%4667%263))3$092:93-588:8/6,%5403/:54327651:860*-50781(5#(+241-97::7;%6457498&20676*714,-.03/%57888:8'24/)-/'7880)50::6674/701662:9:3-4872/&76605689:6..454321668.4752/69229'//05/58)#+00548:3$35-.481:2-1632.144(298&354&02697933749%.17'31435.6/8137880847:7430-2-5461,15549.81345533+0+49616/:53/736906/65.-89*78.4/6;575:.80.3534-35731::647619964.:::57-875-76657:/56)11486:56;3/94778615.-4493113:75873:6/:64223'8775:44876343,24,'103*0481439632:87.610/6&22554:4:39&/35;83635:8:/84-2859:;54941&01*/818:8632/4.485/(59557343-80&3'5/,114764:5442143235%69-4+76004:4635999344139962/24.721:1:.0458858.4335::8::915/46544398:5/79/.67:936268/:9/-.7'49;64938.57:4)8&4:29::92953,7/,/99;./3:59581206+789859/7-34;932(3:475.65/816915125;/:::3-7::82(-662.0/7635.,47244186;664369.19566640)6651&/-::6676,54430)$54-9954.569;/7.747:423:79.66-(2/63),*-+-//34,542/1035450430446/112+(/05.+31+/553.4//.2-6.6-6431.6061-,/,4-025*/-.162255105&$2-4665,20151,5/,5.01,.2/44.60.50.1(4353165.//4///&0460.+452*2)4'34-/3.1/34662#000(&2+44/0335%-,0/3,54041/%11),*,2&.+3-'&2),++.15365343-5--*-00521)2416-%244/)0304(4465145/00%-0*36242/.2*-.+246505*0$.2))40.4+153500/26555./402(.%)+%1.(///1.,'52044400.1%1+-%&(*/-*),%*0/$0-.$.)(&,'--*032020/0).25(41&1/.,)1)%,2/21/,$0(//1.2025+5555.2104556-41,+2,0,&0.*+-'110.-/21&/0,+0,-1/)+0+.-$%((.,)&0/0(2*+01/*.$.-*-'+-,+0,111.,-'''--.0.-).0-,.-+&(01..-&00010+01/$&$+0-10(&,+/1%+)&,+101.(101011+1(-.211.-&,10,11+.-+'-+-&-/*0,0*0.(0*++,0*%21,/&,0, @rCer/1948/25_1851_CCS ATGGGGTCCTGTCGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAACAACACCGAGAGCATCCTAATGTCCTATGATCATGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACCGTCTACCTTACCCCTTACCGGGTCATCTTTCTGTCCAAGGGCAAGGATGCCATGCAGTCCTTCATGATGCCGTTTTATCTCATGAAAGACTGTGAGATCAAGCAGCCGTATTTGGTGCAAACTACATCAAGGGAACAGTGAAGGCGGAAGCGGGAGGTGGCTGGGAAGGCTCTGCTTCCTACAAGTTGACTTTCACGGCAGGGGGCGCCATTGAGTTTGGACAGCGGATGCTCCAGGTGGCATCTCAAGCCTCCAGAGGTGAAGCCCCCAATGGAGCCTATGGCTACTCTTACATGCCCAGCGGGGCCTATGTCTATCCCCGCCAGTCGCCAATGGAATGTACCCCTGCCCTCCTGGCTACCCCTATCCACCGCCCCCGCCTGAGTTCTATCCAGGACCCCCCATGATGGACGGGGCCATGGGATACGTGCAGCCCCACCACCGCCCTATCCTGGGCCCATGGAACCTCCGGTCAGCGGCCCCGATGTCCCCTCCACTCCTGCAGCCGAAGCCAAGGCCGCAGAAGCAGCCGCCAGCGCCTACTACAACCCAGGCAACCCTCACAACGTCTACATGCCCACGAGCCAGCCGCCACCACCTCCCTACTACCCACCGGAAGATAAGAAGACCCAGTAGGCCCTCTGCTCCTGCCTCCCACCCTTATCTCTGTACCCTACCCCTCCATTGGGGCTGCACTGGGGCTGGGGGAGGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGAGACATTAGGGCCCCCGGCCTCAGGAGAGGTGCCGCCCAGCTTCCATGCCAGCCCAGAGCCCACAACGCTGCCCAGTGTGCCTCACTCACTGTCTGGGCTCTCCTGGGAGCACGGGGCATCCCTGTTCCTGTTTCACTCTCAGCTTCTCCCCTCGAAGGGACTCTCTGGCCACCTCCTCCACCGCAGTCCAGCTCCCTCAGTCTGGCAGCCACTGCTACACTCAGCCTCATGAGCCACTTCAGACCAGCCAGGTGTCTTCCCCGGCCCTGCCAGGCCCTGCTCACATTCCCTCCGCTGGTCTATGCTGGTCTCAGAAGGCCACCGTGTCTGCATTCCACTCAGCCAGGGTCCAGCTGCAGCCCTGCCACTGTCCTTCCCTTCCTTGTCCTGAGTCATGCTGTTGCCACCCGTGTGACTTTTGAAGCTGTAAAATGAGCTTCCAGGGCTTGGGTGGCGTCTGGGCAGGGCCGCCGAGGCTGGGAGGAAGTGCTTCTGCCTTTCGCTGGTGTTTCTGGAATTTGCTTTCCCTCACCTCTCACTTCCCTCTAGAAGGAGCTTCCTGACTGGAACCAGAGAATGCATGTCTGTCCACTTTTGGGCTGCTGGGTGGGGCTGGAAACAAGGGCCGCTGACCCTTCATGCCGGCCGGGACCTGCCACTAGCCCCCCAGCCTGCTTCTTCCCTTAAGCTTCGTGCCCCTGGATGCGCTAACATTCGCTCTTGTTTGTTCCTGGACTGGCCATGAAGTGAGGAGATGGTTATCTAAAGAGAATTCCCTATTTATTTGACAAAAAATCCAGTTAATATATTAATGTGAAATAAACCCTGTTTGCACCTTGATTTGTTTGCTGAAAATGTGAAATAGTAAAAATAAATAACTGGACCC + 7?0>>?@9B9AB@>B=;F;B@A@::<@ECBC@CC3CD8D6:AC=F69<9CEC@@:?B6BCBD>FFCBDB@FEBGEBCFBGCD?EBAGADE0ED3ACF6EBDD;GC+<@E?C??C9=?F8>77E>G>AC@B9C@?DDCD>EFF>C;:CEG.BEEADCB?9C,AD/CGDGE@E,ACCEGGDBAC@7EGCCFCGGE2@:FG;ED=A?D@@BEB>EEEAB$D@EF>GE38,6;5FA=A:@<;DCG/>?>G>CGGC8E2=A>F8AA>9GG>=EB?C89.8B?FCDBAFGCGBG6BDCE7CC>FEED=CGDAC?GE:.ACCDDEBG@7C905E;DE=GFAGFEC>FDDBG8+BDD@9EDCG?D=GEEC)A<9BADE2CAD@BB)D>:?>>BBG;E:@/5CC:?E+EEC>BEFC:FC?A.FA,>;@89;<2GCC;;.@BA2A8=C@>?7CC>3>?<<<0@A+CA?>91>=6<8;C3>6=6<:>8=,A?@<1467=>7<;A:A5;8=?;&;;>==?77@C@7&A@B=.>A7<=.@<>>7==05?>;CC@B9C>C=C<=BA@@?5905=$;=>B@>==3BC>84<>?A?A7?8;@7?=/><.<5A>B;@?B@>;9?5>8AA5-<<1?/@B>?67,=6,<51+AB9=;>;C(=58&45&3)>:<@CB+EE9:@C3?;8DCCDC@$D5;B6EGFEAC:>>;5GGFC>)><==<%>?DEFFAA>F??B?:(9=@>EB>EABFB?7>@C5BCC2A?C42>>8@DEB;B@AA@BBDFF?>C?8=B-D<0GFDA:D=E>E@/?E4E:GFB8CC5@EE?C=>DDA/@)BDF7CEEDEA(FCEC39CAC@B,@CD@?>;@;@@DA?18A>C@+CA<>FBB,GEDA@D$ACAD?F4?:FACBA7EAAF=>AA?GBA*FABCEDEA8BEC6EFF7DAD7D44CF;D?=DA@BAF;7CFDF=ACDFA@9;@C3=BBC??7?=E3GGG@G8AG>E4D;;B>GAB7?@?CCCAD2DF?5G@=::F=:=?A;6@=CCD:EDC8FAF;F>3BBA8A6?EFF8A,CB;CD<@>CC3CE?BE>:?FDABEAGGFE<=<39=A?F;F(CE?G1F8DFEDB@CD;=EB=DF@@:EB+3-$B>DFBF:DF0EEDC8DEF@CB4>FA;DFB==C2E>)B@?;F7?@C)DB>BC?3GD(A>7GA?4GF>AAFB?DD3CC=D5?9GEEFEF@BA?7ADD@3=8BAFF=?:FE,AAEEB3@AACB;8?F@GFFCC?@BDADAFC=GAB=>>C@6:;D-:;BD5AC>:=<;9@<:9CD0EFE@CG7<99<-?C1@BA>CB2@B?FA>>83CAG9=0B:27A<;0DEB>D:,GGGGGBBBE?B60:=87$?=DD>EED;D0GDD@6D?CECBE>4>CF?GFDDB<-@<:ECA>ECADFGE:B6EBCBFFEGE;C<5ADB=BBDBGFFFE@EB8E9D,BDAB8FED4=?>>B.@ABBBCFGEB@B;CDDB@8G9BEF9DF @rCer/1949/2069_89_CCS CCCCTCTCCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTTGCAGACATGATCCCTTGCGTCCTACAGTACTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTTCTGCTATAACAATAAACTGTAGATGAATTT + 176*859=;<075192=:45;;;5)5679546%6176<3'4.7*8<71424(94;?B9)<9:<;7::?.4?;:=7>;;:.=0>C?CC>BA>7?B;?71?<>?<9B=A>BCCBC<3BCBAA<=1;A6B;><=;<7?@A<@?>BC9=;<27>7;B>?A6>?>B@@74>>C4@B=?;>>?@<8)889:=>2>94@>6>;0>A@?96471=394?.:>;<8C6@?;6346@A66>A>C==CB;@C=>@>9<;A'995?>;=AB;98:&A@1C;>58=&>7=@=>@@=B?/;<9@<<87=/99979=;B?<+A4;@88:2.6;6AB@1:>9C@AAAB8>7?C6A=:AC7=?2<;5=;4+6;BB?A92;;4:?=;3@>5<>;25$A>>BC@86<65>@0C8&;==+A7AB-?=>AB?;@5=2?5;>>,>:@>?69>A;9959=48>:BB>8:@?AAC=B:CB<@B6==<79??A=.>9@5=?:>C:?>>>A4C=<7-=;?>B@CC?@1>);>>?>-5<<7:5=>><:=&<778:9,:8<2?;=@7?9@8<@>A>;=@?A:?4>>@9A9B?A<2A?C@>:??8:??;@=A@.B=89<9>C?=>::4?8=?7BA;B@AA;/:8?6AAC5C:B=@AA?:>;CC?C==A@=@;=CA=>>=BC:A9@@7==>B=CB@=:6?B=55?;:??7A?AA:BB>?=<@29A=64;6C=B=??9?>CA@=@CBAAC?8ABBA8AA5>;@B@C@@AA@?@.1?A,:7==-<=;*?B>>9:,9B=<<>>3B:;<'AC;::BC@B>><;&<97+=>3/<>:==?:>>8=1;)<=>?:1;98=7);9?8>6/,83>>;=<;?=>=8>5;>><;+91;987379:;4:0<9<9>;=>9:1;07<5=27=87;::<9<7<;7<251444+7599>><>67=5>><7>;>=87=;88989>:9=8=;>=<=:94<7:99:(8==?-<==(<97::+9:=:7<8=97;::=?>??<>=>>;7;6::'466.:<>8988=*549+><==8:=??<:7<7*<8=:>>=02427:2=?<>=>;>?47><5>=<;>=5<2=:)9<=8>>=:==:>;7883=888>8.=<6>>>?==69=28>=093=439<46)):701175;8:0275:3:79169=975105*6:>:=:;;??:>=:8=>>=9==8=8275464:??28==49999:>+:>;6:;<884672/1//2'6>=>7>265:4=0.25375:;?<;=:=43:7969;5>:>-7;<6:;;;:,=;=>:79<::7:=9:127/<083>443,90:=:=>9;8<;86:>0*=7;=>58,>8>>=;7==::9:>=?3;:7=6;;*:><2:?<;??99:;0=?19;?;9?<:><:>>6=<3;::>>?>9;593;:=8=66;1?=;=<289;<>:5$:$;3<84=><<=9;>=9.7;6:=:;?>?=6<9'>0752343?98>8>:5;6;>>4=7:;8:;80<+28;<4,:7=>>;9?;<7>;=8;+>68*6<>5;99>>?:>?><9.;>>>>/?6<5>?39>:;7;??3:-;:>>=>;88=:=;6;:=;:,<9;852+2;99??5<==,;:==?>99;5=:3<7=89:9><:)5;:.:?<=4=:91>=>:<=;<<627*7:=;=>>?;?9;<9867=99=8:;=9;=9<9>;<9==7??8>>;;89=5;=/:;>=43962899&6>58:9>738<6:=>17:<9;;77<:5=<5 @rCer/1951/25_1669_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCATGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTAGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + KK(KKKKKKKKKKKHKKKKKKKKKJKKKK>KJKKK;KKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKJKKJKKJFKKKKKKKKKKKKKKJKKKKKKIKKKKKKKKKKKIKKKKIKKKKKKKKKKKCKKKKKKKKKKKKGKK;KKKKJKKKKKKKKKKKKKKKKK%KKKKKKKKKKKKBKKKKKKKKKKDKKIKKK8KKKKK:KKGKJKKKKKCKKIKKKKKJKKKKKKKKCKKKKKKKKKKKK?KKKKKKKKKKKKKKKKJGKGKJKKKJKKKK2KKKKKKKKKK5KKBKKKKKKKBKKKKKKJKCKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKAKKKFKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKJKAKKKKJKJKKKKJKHKKKKIKK?KK'KKKIKKK)KKKKKKKKKKKIJKKKKKKKKKKKKKKKKJ(KKKKKKK>4637:85376<4976+.59-74059834737875355&4%97;7255653<:-:4<5>6=739:7+;38+:0856149<8.41/3/334+0:::9;/:637.;35<97)<9>:86:<57>6;85<=6=)69=?:3=:>.;93==/:=;*8<89694>7>=;:;9:770>?4<546<819.>>=96;>3;18?4;20697412;26:73,93/.*),7.513;..3/4814.3-34236816,:248:29972;5::137)1+=674673189909:8271+14969:92-2459451+,.6--.26.4*-578:1164.204*37:.4601556:6454595552-+0-86544147;58/62+4,1((&6-/4961'222%5.566069747642002-542(3015#74954439303663820.815/%'0+0+58::48::9:-54818749540418577153352(5579648161:5456;5:6806::5;9;286.287756266/649:;3:18/5,45.-6522&75:794)24.:8:57792543,46289537346.0864475,398+45167:7377//8(1:;719::4+2/(*818:7613440,-510575,776522&843/025-.522032//3/463,4956212+76*887341'30366593,&2&113;96657&3.561153*0-42:9:1;9;8/956574&/-66*673;9577:091::570743%,68..37857/:762;;2:87:2;973'8:36276478:;293:7722579539:8,64677::6853//656,/,-&557.513)3176.8:9:99/.474/1487-91+/,955434762-7468.6::6533)27617834.5/6:49:3935(33560+5:75/19579875;785856532)565:1:543:;:;683,406608-6178559985:443.;77416-3-5245+21#26866)/16371/2-2.122-5510434.13(42,3+2.2,13/,(/.1/2.25-032.4,/41,(/-,-0*%01.'.*202136.37602084-6530/64074655646698:5276624-75926-3-/65%75:57-52.+2%5+-34276(#.109914//42330001.(1/(025+&0,-*/(/399:0)$..023*/(1/-(4453.34234/6638./6348842.660(12/303)*2(32&.2.&/56./05.70:588:13/7;8,643,$&8875/#(-869-7:22:86556745:095413-2,3*89%5:675246882-35755407848/355&8*/+0%6555,789950:76069588957485.&8+:6765::878/817379:79465;7768,::433850..*45,375578:6333387334462%7622157)623+1-33.-*41(41/21432.35499/47:1359(747;4;7516851739784335738.946057;9;226/5351:2964509901544589:24+4235:;399865802799:6676:7371.444:965:4.48;67882768684+:3:778;766*/-772/)15-2710/529/668::.479///4579072546$545664541'646/3021,6457:9-58:61).9564(0587479;68:5491::8723667:5+0/8 @rCer/1960/2074_59_CCS ATGGGGAGGCTTGGGGGCGGGGCCTTCCTGCAACCTTCGCGGCTCCAACATGGCTCCGCGGCTATGCAGCATCTCTGTGGCGGCGCGGCGGCTGCTGGGGGGCCCGGGGCCCCGCGCTGGGGACGTTGCGGCTGCAGCTGCGGCGCGTTTCTATTCCAAGGACAATGAAGGCAGCTGGTTCCGCTCCCTCTTTGTTCACAAGGTGGATCCCGGAAGGATGCCCACTCCACCCTGCTGTCCAAGAAGGAAACCAGCAACCTCTACAAGATCCAGTTTCACAATGTAAAGCCCGAATACCTGGATGCCTACAACAGCCTCACGGAGGCTGTGCTGCCCAAGCTGCACCTGGATGAGGACTACCCATGCTCACTCGTGGGCAACTGGAACACGTGGTATGGGGAACAGGACCAGGCAGTGCACCTGTGGCGATTCTCAGGCGGCTACCCAGCCCTCATGGACTGCATGAACAAGCTCAAAAACAATAAGGAGTACCTGGAGTTCCGAAGGGAGCGGAGCCAGATGCTGCTGTCCAGGAGAAACCAGTTGCTCCTCGAGTTCAGCTTCTGGAATGAGCCACAGCCCAGATTGGGTCCCAACATCTATGAGCTGAGGACATACAAGCTCAAGCCAGGAACCATGATCGAGTGGGGGAACAACTGGGCTCGGGCCATCAAGTACCGGCAGGAGAACCAGGAGGCAGTGGGCGGCTTCTTCTCACAGATAGGAGAGCTCTACGTGGTGCACCATCTCTGGGCCTATAAAGACCTGCAGTCTCGGGAGGAGACTCGAAACGCTGCCTGGAGGAAGAGAGGCTGGGATGAAAATGTCTACTATACAGTCCCCCTGGTGCGACACATGGAGTCTAGGATCATGATCCCCTTGAAGATCTCGCCTCTCCAGTGATGCTGCCTACACCTCCACCTCCTTCCCCTTCTCCCTCAGGCAACCCCGATAGACAGTGGCACTCCCGGTCCTGCTATCTTGGTTTTGTCTTGGCTCTGGGAGGACTCTGAGGGGCAGTGCTCAACTCAGACAAGGGGGAACTGAAGGCTGACAAGTTCTGAGGATTACAGCTCTGCCCAGGCCCTTTCCACTTTCCCTGCCTGCCTCCTTCCCCCTGCTAGAAGTAGTTTCTAATTTCCCTGAATGAAGGATAGCGATCTTTTAGGCCTTCTTATATGTTCTAGAATTCCTCATCTCAAGGCCACAAGTCCCCAGTTATCACCCTTGGAAATCCTCCGTTTAGCTTAGTTGCACAAAAGGTAACATGTCCAGTGGCTAGAGGTGGGGTGGGAAGACAGGACCCCAGGCCAGGCCCTAAGGAATTCCCTGGTCTCCACTGGGCCACCCACTTGCTGGACAGTCTGAGCCAAGTCCCTCCTGTTGGAGAAAAGCCTGGAACTGCCAAAAACAAAACAAAACAAAAACCTCATCACCATGGTCAGGAGGAGGTCCAGACATCCCACCCAGATAGGCTGGGGAAAGGGATGGAAGCCAGGAAAGATTTAGGGGCAGGAGACAGACACGTAACAGGAACTCAGAAGGTAGAACTTAGAATTCAGAACTTGGGTTTCAATTGTAGAATTTGGAATCTGGAATACAGAATTGGGAAGAAGAACAGAGATGACAAAAGACCATTTGAAGAGAGGTTCCTAATACTAGAGAGATGGAGAGTGGCTTGGCTGTTTCCCCCTACATATTGGGGTTGAAAACTTAAATGTGTAGTTCCAGTCCTTCTATGCAGAAAGTCTCTGCTGCCCTCCCTCCTTCCTGCAGGCAAATGTGCCACCTAGGGCCTGTTCCCTCACCCTGTATTCTGTCTCCCCTGATTGACATTCTGTCAGCCCAACCCTCATTCTGCAGGGCCACCTGGTGTGTGGAGGGGGGGCCAGTGACTCGGCGGGGTCTCCTCAGTGACCCCCATACCTCATCATGAACCCTTGGGTAGCTTGATTCTGCCTCCCATCCAGGAAAACTTGTGCTGGAGTTGCTGATGGAACCAATTAAATATTTAC + KIKKKHJKHKKKKKKKKKAKKKKHKKKKJKKKKKKKKKKKK.KKKKKKKKKKKKKKKKKKKKJKKKKKKKDKJKKIKKKKJKKIKKKGKKKKKDKKGKKKKKKJKKEKJFKIKKKKKBKKKJKKHKKKJKKKKKJKIDJKKDKKKKIKKIKKKKKKKKKKKKKKKKJKJKKKJHKKIKKIKBJKKHIKKKKKIKJKKKKKKKKKKKKDHKJKKKJKJKKKKJKKKJKKKKGKFKKKKKKKKK-KKKKKKKKKKKKKJKKHKKKKKKKJKKKKKKKKKGKKKKKKKKKKKKKKKKIKKKKKJKJJIKKKK5KKKJKKKJKKKKKKKKKKKKKKKHKDKKGKIKKIIKKKKKKKKKKKKKKKKGKKFKKKKDKKIKKKKKKKKKKKKKKJKKKGKJKKKIKJKKKKKKHKKKKKKKKKK:BKKKKKKKGKKKKKKKKKKKKGKKKKKKKKKKKHKKKKKKKIIKKKJKKKKKKKKKKKKKKJKJKKKKKEKKKKKKKJKKKIKKKKKKKKKKKKKKKKKJKKIKKKKKK8KKKKKBKKKKKKKKKJKKKKKKKKKKKKKKKKIKKKKKJKKKKKKBKJKK9KKKKKKKKKDKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKIJEKKKKKKKKJKKKAKKKJKKKKKKKK;KKKKKKKIKKHKKIKJKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKCKKKKKKKAKKKKKJKJKKKKJKKKKCKKKKGKKKK?KKKKK1KKKKKKK>KKKKKKKIKKKJKKKKGKKKKKKKKKKKJKKKJKKJK@KKKKKKKGKKFKKHKKKKKKKKKKKKKK;KKKKKKKKKDKKKKIKKKKKKKKKKKKIKKKKKJKKKKKKKKKKKKKKKKFKKKKKKKKKKCKKKKKKKKFKKKKKKIKKK?KKKKKKKKKKKKKKKKKKKKJKIKKKKKKKJKKGKKKKKKKKKK38K6KKKKKKK=KKIKKKKKKKKKKKKJKJKKKK-$KKKKKKKKKKKKKHKKKKKKKKKDKKKK8KCKKKKKIKKKKK-*AA&>KKCKKJKHKKKKKKKKKKKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKIHJ@GKEKKKKKKKFKEKKKKKKKKKKKKKKKJKKIKKKKKKKKK;KKKKKKKKKKKHKKKKKKKKKKJKKKKKKKDKKKKKKKHKIKKJKKKKKFKKKKKKKKKKK6KKHKKKKKKKKKJKKKKKKKKJKKKKKKKKKKK=KKKKIKKKKKKKKKJKKJKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKIKKKKKKKKKKKJKJK0KKKKKKKJKJKFKKKKKKKKKKKK @rCer/1961/4715_76_CCS ACAGCTGACATAGATCAATAGCTGACTGGAAAGAAGTAGAGGAGGCAGTTTCTTGACTTTCAATGTATGAAAAAATTCTTATTGCTCAGTATTGTCTTAGTAACTCCTCAAAACAAGGTCTAGCGAAGTTCTATTGTTTTGGTAATTTGTTTTTTTTTCAAGGGGAATAAAAGCGATTAAATGTGTTGTTACTATTTGGTGTACGACTAATACAACAGCTTGAAAAATCATGAGACAAAAGGAATAAATTATTAATAGTAAATCGACAAAATTTTAATTGGTTATTGTAGGAATATACTTATAATAAGTACAGATTAATGTGTTTGTATCTTGGGTTTACAAAATGATACACACGCTTTTGAAAAATTATGAGCAGATTGTAATATTATAATTAAAGTACTAATTTTAAAATTGTATTGTGGGATTGTTAACTATAATTTAAGTGGAAAGATACTTAAAACCTCAGTTGTTAACACTTGTTCTTTTAATACAGACTCACAAGGCAGTCCGAAAACTTGTATGCTATGTTAAGGAAAAATGGTCTGTTTTTAGGGAAAGCAAGTCCAGCGACACCAAAGAATAATGCCAACGAGAGATGTTGGTCCTTTGTTACTGTAGTAGTGTGAAAGGGTGGAGTGTGCTGGTGTTAAAGTCCTAATAGCTTTTTCTCCAGGATTTGTGTTTATTCTATTCAGCACAGTCCAAGCCTTGGTGAGCCATGACTTGCAGGTGGTTTTCTTGGCCTTCTCGAGCATGTTTTGGCATTCGTGTTCCTGATAAATTAAAGTTTCATGGGTGTTTCGAGTATAGTAGTCCATCTGACGCTTTCTTTTTCTTGTTGTTTTAAGCGCCACTCGAAGGATATTTCAAGTGATTAAACCAGGGGCCATGTCGCACTTTGGCACTGATTGGTCTAAAGATTTTCCTGGTTTTTGTGTGGGCATTGCAGCAGGGTTCGTCCAAAATGTAGTTGGCTCCTGCACATCGTGCTATGCATTGCCGTGGACCTCTGTTTGGTCCGGCTTACTTCATGGAGATGTGGAAGTTTGGCCACCATTGTTCGTCTCAGGATTTTCGAACTCTTTTCCGACACTGCAGCATGCTGTTCTTACGCACTATCAAGGACGTTATTCCTTTGTCCAGCACCAGAGGGTGGGGAGGAGGACGGGCGCGGTGGCCCCTCTCGAAGTGCGTTTGGGTTCTTGCTTAACAGGGCATGTCCATTGTGGCACTGGGTTGCGGTATTGAATTGCAAGCTGCTCGCATTCATTATCTTTTTTTTCTGTCTTTTAGCTCAGTTGGAGATATAGACGTATGGATAGTACTTCATTCCAATAACTCGATCCATGAGATCTTGCGTTCTCGTCCTTCGCAATTCCCTTGTTCTACCATCTTTTAATGTGGGTGGTTCTGATGTTGTTCCAGCTGTTGGCACTGCTGCTCTCTTTTCCTGTGCTTTCAAAAGAAACTCTGGATTGCGTAAGAAATGCACACAGGGCGGCCCACCCTCGGGCGTACATTTGAGAATCTAGAAGTGCGTAGGGTGATGTTAGACGCCTGCCAGGACTTGTCTTTCGCCCTTGTTCTTTCTTCCGCCTAGATTGTCAAGGTTTATCAGAACGGCTGGTTTTGCTCGCCGTTCGAACGCAGTACTTTTAGGTAGCGGTACCTGGTGCAAAATGGCCGTCTTATTGAACCTTACCTACAGGACAGTATGCAATTTCAATGATATAGTGAGGTGGACAGCTGAGTCAAAGCACTCCTGCTCTCTCTATAGACGCATTCAGATGGGCGTGTGTTTTTGCGATTTCGCCGACGCTAGTTTCTGCTGATTAGGTCAGCACCACATTGAGTCCATGTGTGACACTTATCTGTCCTATGATTCTTCGCGAAGCTTGTCTCTGCAGTCACCCTGTCGGCATCTTACGTCACTATTACGCATTCTGTTATGTGTAGCCTTGAAAATGATACAAGTATGATGTTTTGCTCTCTCTGATCTTTGCTAGGATACAGGGTAAGTATTGTAGTTTTTTGAGAAGACCTAGATGATTTCGGTTACATTAGTGCATCCACAGGTACATATCCTCGTTCTGTAGAGTTCCACACTTGCTGGTACACTCTCTCTATGTGCATTTAGTACTATGGGAGTTGCTTCAGATTGCTCTCTCAGTTTCGAAGCGATTTCCATACTTCGGGGGCGTTTTTGGCTGTTTGTGCCATATATATGGACGTTGTATAATATTGGCTATAGGATCCAGTGTTGAAGCACTCATATTTTTCTCCTGCACCGAGAGGAGATCATTTTTCCGATTGTCTCTTTGTAGAGATGATACGAGCGCATTTTTCATTGTGAAATGACAGTGCTGATTCAAATAGCCGATTGGATTCATTGGTTTGCAGAGTGCAGCGTGTCTCGCAGAACAAATTATTCGCTCATAAATTAACTCGTTGGTTGTGTTTGTGCCACCAGCTTCCAGAAAAGAGCGTATTAGTATGTGGGCATCGCACCTCAAGGTCAAAGTGATGAAGGAATCTGACGTTATCTCTCTCTCTGCTCGCCGTTGCTATTTGGTGTGCAGTGGTGGAGGCTCTTGATTAAGGTATCTTAAAGTACAGTAAATACATCCAACTTTACTACAGGATTTCTGATTTCAAAGGCATGTTTCTTTAGTGAAAGTTTCGGTGAGGTGATATGTAGAGCAGTTAATTACTAGGGCTTGAAGTGGCGCCTTAGCGGGCCTCGTGGCAAATATTGAGGATTTAAGCCAATTGCTCGTGCCTGGACGCTGGCTGTCAATCAGAGAAATATGACAATCAAGATGATAAATTGGATAGAATAGGTTATGCATGGTTTGAGTTAGAAAAGCAGCAGCAATTGAGAATCTGGAATCAGTAACTTAGTGAAACTTTCATTGAACTGTTGTTTGATTGCTTCGGTCTAGTGCTAGAAAAAGATTTTGCAGAGCCTGGAACATCACCGGCTGCTCTTTGTATAATAGTTGCTGCCAGTGTTATGTTAGGTTATCATTTTGAGCGATGGCCATTTTGCTTGGTCTTGAGATGCTTCGTGTCTGCAGCTTGCATGCAGGAGTGGTGTTCTCGTGGGTAGGGAGATAGACGTTAATTCTAGAACAAGCTTGGCTGAGTTTTTATATTTGTTTGTAGGAGGCCTCCCGGACTGTTAGGCTGTTTTCGTGCCGACTATCATTGTCGTGCTTATGTGCTGGTCTCAGTGATGAAGTGGCTGGGGTGTTTGCATCGGATTGAGTCGCTGGCCGATATATTGGGAGATGCTCTAATGGCGATTACTTGCTCTGTCAAAATGTTGGGAGCTGAGCTATAATACGTATGCTGCGTATCGCTAACTCACCATGATTAATTGTGACTAGCAGAGTGTGCTAGGACATAATGAATCGAGAGGTACTATTGATGTGGTATAGAGCGCGGTGATGCTAGAGGCGTGGATTATAGAGATTGCCTTCGAATAGCACTCGTTCGATATCTTCTTTTCTGTACAAACGGTGCAGTTCTGCGCGATGAGGAGTTGCGAAGATTGTGATGTTCTTGTTCTTGGGTGCAAATTTGTAGAGATACGATCTCCAGTGTAGTGCATTGTTTAAACATGGTGATTATCGCATGATTCATTGTGCGGTAGTACTCTAAGATCAATATCTTACGTTCTATAAGCACACAGTATCGAGCTGATAATGAATACTGAGTGTGCATTGGTGGGGGCTCGCTGGAAGCCATGACGTCGTACCTGGTGGTGGTTCCAGCAATCAGATGTAGTTGCTGCTACTATGTGGACTTGTACGTGTCCATCTCCTGTTGCTTGAATGGTCCCAGTGTGAAATATTTGTACACTATGTAATATCCCTCCGGGATGTTTCTTACTCGTGGTGATATCGGACTAGAGGCTCTTATTGATTGTTGTGATTATGATCTGCTATGCGCGTTTTAGGACGTTGTCTAGCGCTAATCAGTGAGTGGTAGTGGTCGCATGGAATTCTTATGGGCTAACATATACGCTGGTAGTTTCATAGATCGACTACGGACGGTGCACAACGGTGTACTCCTCTCGCTTATTATCTCCTATATGTCTGCATGCAGTGTTACTTTTCTGTCTGCTCCAGTATGCTCTATTGTTGCTATTTATAGTTTGTATGGGATCTATCTGTGGCTCGAGCCCTGACTTTCTGTCCTACTCACTACTCTGTATGTGTCTTCGCTAATTTGTTTGTATGGCTCTATCTGGCTGTATACTGTGTTAGTGGTGTGGGTTAAGTAGTCTATGTCACTTCTATTGCTTGTGCGAGTGCGTGTCTCTCGGATTGAACTATGGTTCTTCTCGTCTAATTTCTCTCGGTGGTAGTATGGTACTGGTGTGATCGTTCGTGTAGGTGGTCTGCTATGCTCTTGACTCTTGTTCTGTAGCTGCATGGCTCTCTTTGGTGCGTTCGGCCAGATGCTGATCTGTTGTGATGGATGCGCGCTTTGTCCATGTTCTTCTGATCGAGTCTGTGTGTACGCTGTGCTGTGGCGGTGCGGTGATTGTTGTTGTGCGGGATTAGCTGTAACTATGGCATGAATGTAGGTATTGCTCCGTGGTATAGTCCCATATAGTAAGTACTCGATGCGT 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@rCer/1963/25_1714_CCS ATGGGGACTCCCCGCCGGCCGCAGCCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCCGCTCCCCCAGGCATGGCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGATGGTGAGACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAAGGAATGGCGGAGTCGGTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTTGCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGTGATGCGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAAGAAAGAATGAAAGAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGAGCCATTGACAGATATTGGCCAACCGCTGATGGGCGTCTGGTTGAATATGACATAGATGAAGTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTTGGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCGTATACCCGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGAGGTGGAGATGGAGGCATATTGTATGAAATAGTCAAACTAAAACCAAGATGGTCACTATGGTAGAGATTGACCAAATGGTGATCGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGCGATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATTCCGGTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACTGCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATTCTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGTGTCAATCTGACAGAAGCGCTGTCGCTCTATGAAGAACAGCTGGGGCACCTGTATTGTCCTGTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATATTTGGAATTGTGGGTATTTTACACTGTTTGGAAGAAAGCTAAACCTTGAAGATCAATAGCCCCTAATCACATGTGCTGCGAATGGCCTTCCTGACCTCCATATGCTGTACATGACATCGAAATGAGTCAGGCAATTTGATTGTGAATTCCTTAAAGTTTTCCTTTTTTTAATAATTATTTTTAATTTAAACAAGCAAATGGCAAATGTATATTTTGATGAGCTTAGGGTGTTATTTTTTTTGAAAGTCAGCTGAAGGATGGTTAGACAGCACAGCGAAGACTGCTAAATGCACTGACCTCCCCTCCCCCGCCATTAGAATGTGATTCTTGTTCCTTTTATTTCTCTGTGGGCTTTTGTTTTTGTTTTTGTTTTTGTTTTCGTAGATCTTCAATTTGGATATTTGGAGGAGTAAACATCGTTGTTTTGCTGGAGGGATGATCTTGATGATGTTTCTTTCCCCAAAAATTGACTTAGATATTAAAATTTGGTGCTTATAAGAGAGAGTTAAAAAAATAAATAGGATTGCTTCAATTAAAATTAC 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rCer/1964/25_2226_CCS ATGGGGGTCATGAGCCGCTGGCAGCCGCCTCCGCCGCTCTCCGCGGTGCTGATGCCTCAGTGCGCTCCGTTCCGCCGGCTGCTAGCGCGGCCCGGGCCCGCAGCATATCCGCGGTGCTGACCTCGCCACCCTCAGCCACCGCTGCCTGGAGAAGCGTGCGGTTGGATTTTTAAAACGCCATTCTTTATTAGATTCCAACATCCTCGCGTTTCTCTGTGCCAAGGGCCCTAGGGCCGTCCGTCTCCCCCTTTGCTCTCCCCAACTTGGCGCGCCCTCCCCCCATTCCTCCTGACACTCCACCACCCCCCTCGGCTCGGCGGCTCGGCGCGATGCTGCAGAAGACGCACTGAGTCCTTTTGATCTAATGCGCAGAGGAGTTGGCCCAGAGCTCTGGCTGCCCCAAGGCTGAACTCCGTCCAAGGTGCCCGCAGGCTCCCTGCCCGCCTTCCCATGCCAGCCCGCAGCTAGGCAGGGCAGCGGCGGCTGGGTTGGGGTGGGTGGGAGCTTTTGGGAGGACAGGTCGCAGCTTGGCTATGGAAGGCTCCAATGGCTTTGGATCGACTCCATTCTCTCCCACCGCGCGGGCAGCCCCGCCCTTCCCAAGGGGACCCCTTGCTTGGGGACTGCCGTTCGCCCCTGGAGCTGATCCACGCTCAGAGAGCAGCAGCGACTGCTCTTCGCCAGCCTCTCCAGGAAGGGACTGTCTGGAGACGGGCACCCCACGGCCTGGTGGGGCATCCGGCCCAGGTTTGGACTCCCACTGCAGCCCGGCAGCTCTCAGCCCCGGCCAGTCGCGCACCGTCACCTCCTCCTTTCTGATCAGGACATCCTTGCCGACTGCAAACCACTCGCGGCCTGCGCACCTACTCTAGCAGCGGGCAGCCGGCAGCCCCTGAGCCTGGGGGCCGCCTGCGGCCAAGGCGGGAGGACTTTAGAGACAAGCTGGACAAAAGTGGCAGCAACGCTCATCGGACTCTGAGTATAAGTGAAGGAGGAGGGCGACCGCGAGATCTCCAGCTCCAGGGACAGTCCCCCGGTGCGCCTGAAAAAGCCACGCAAGGCGCGCACGGCCTTCACCGACCATCAGCTGGCGCAGCTGGAGCGCAGCTTCGAGCGGCAAAAGTACCTGAGCGTGCAGGACCGCATGGAACTCGCCGCCTCGCTCAACCTCACCGACACGCAGGTCAAGACCTGGTACCAGAACCGCAGGACTAAATGGAAGCGACAGACAGCCGTCGGGTTGGAGCTGCTGGCGGAGGCAGGCAATTACTCAGCGCTCCAGCGGATGTCCCGTCGCCTTATTTCTACCCGCAGAGTCTGGTTTCCAACTGGACCCCGGCGCGGCGCTCTACCTGTACCGCGGCCCAGCGCGCCGCCGCCCGCTCTCCAGAGACCTCTGTGCCCGCATCCTCATCCACGGACTCCAGGGCCCAGCGAGCCGCCCCGCCGCTGCCTCCGCTGGCCGGCGTCCTCCCGCGCGCTGCGCAGCTCGGTGAGGCGCCCGCCCGCTCCGGGCCTCTTCCCGGGGGCTCGGCGTGGCCCCTTCCTCCCGCCTTTCTGAGGGCGCGGGTTTGACGCCCCTTCCAGGGAGCGGGCCCTGCCCGGCCCTCCCTGGCGCCCCAGCCCAGTGTCCCCGAAGGCCAAATGCTAAGTCCACTGAGGCCCGGACCTCGGACTGCGTCTCCCAGTCCCCCCTCGGCGTCCTCTCTCGCGGCCGCTCTGTCCGGGAGCCACCCCACCCGCCGGTGTACATACGCGTCTCTGCCCTCCCGCCCCAGCCTCTGCCGGCTCCCCTAGGCGCCCTTTCTCCCCAGGAGCGGTGCGACTGATTCCAGGCTTCGCTCTCTCCCACAACCCTTCCACGCTCCAGGTGGAGAACAGCCCCTCTCCCCGCGCCCCTGCCAGGGAGAGAAGGGGAGTGCGGAGTCCCGTCTCCCATATCCTCGAGCGCCTGGCCAGCGGCTGAGCTGTACATACCGTGTGCAAAGTGTATATGAAGTTATTTATTCGTGAACCATGAGCCCGTGACCGTGTCCGTGGATAGTGAGTCTGTGGCCTGTGCCCTCCCCACTCCCAGGCGGGCAGGAAGGGCTGAGGGGCTTGCCCACCCACCCGACCCAGTCCCCAGCCTCAGCCCCGTCCGGGGCAGCCAGGCTCTCGGTTCTCTCTTTTTTAAATGTCGAAATAAACTTCTTACAAAT 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6-%16441845:97/3183)3798.::5;-.65/:55464447-'0/338.')2442%1(-28:9238:).'26-83:3(55,3+0352-4:5&85.5389.34'/1)-:46/753300')99594;85:5.8354656695&1-661/%06:57635912$2,4:59773-::811.66377.353&5.4)'.-91:6;6*96>>=;3<83%::;4119).*@@:?C>9(<>&9:.3;:%7+'=@@<)726A/9@&>@6+<;%61:>A>>)=<6&11;<<80:5>4(>7&2;=971>;6:1(16049344;@BB9@>,:77:.:>9:5<7B>79AA?7@1;>B?=A718566/165:'7>,<+B@:<;<:3$2&:=8A%9==+:4;8)B:6,?14'==:>>68'?/?@<>3:2<8&?56,AA=:==96;50<;(@>*'#==<21290(@?647/>=0%;965=7A@-@7>>=A>3=57%3:.8@46-7C<.23&=<=CC;8;5=?8A11<<,;A:7=;;54,6>>9>3?B?7/=02>+>;:>.@<<7$=651C0<>C4CCC36>A5;>4?7<+@BB1=@?==?;4&6B=;>9<=A91@7@A@747<:97=>BA:78@><.5817>>86:@:4C9A*>=7=7@':<3:9;B?&<::=2;:@?>9B2B32@;(59<<;;9@;C6B=>8?8=C9:/36(?<2'+7<454>4$5558>;=<>=:&795)#%1-0213:;43528/07-77);;7?&<78466-21%:,2:7:;19;1>=94;8708649-0*/<<69/>3<9374&456991:4250*2)<;<5-6=04516(;997>92883*2=>>6=??:$9=(<+74?0,%/2261<<>0??::=;7*$806+1>/3#,/4577:0.8<195<'5998<'<4)68;<5+//*$2459334?+194(88<>8->=>>=>>3;7684599294,<537<74(<<991:769<8=29&8:978,:7752-1,6105+56=)427=?<>9;>89?79==1630:=7;<92;.73:8887>7=?<=<>=28:%398;;:%68:9<<=988&0:::;>>458::>-,22394,78<=8==57:;1/8.58,849:7:,8377:7<'('':49*.1.-;/:>>9;>4721:>517..7=;9>7;8>:7)05.63452:+82;>6:8989:;<00?>;59968-96<98.5:.265;5;99:3)(&-<>9;6::9-830612:0+-:;77=479877:-:;*1+($63=75;7>717;=9?===8:;5+9.913899994<8165;:9;65:17+220534:&*0'334'09060244*2-6376995?7/>1/$84,=8==%-4'96=642<=327:8;;:11187>18697&5&%44-32158:>9:<=4$.7(7;880;=;0=:91,<>5835%9:-8396?9?=&04::<8;09:7<0=&89807/;4+>><+=)=9/,660:7+8>(68';51;<9(5::,<9>6.842:>&5/*::<;9=?/:(803%3545<04/<>=98)=<7>=>709=6=45(92:-:;)32),78+(769'548:(2326*-<;>7=9;<:;>69;%=<474&7;:845:=>4832:699832;9.61<38:9><25?(<761*72%5778*8:717(2)382493:8157:8&338&:8+$47,$30817370953+:9924.==9310//7%05$4:26*6=>57=5(+'8.394+814851%9:4;3,638:=9:=9+:<597?%556=-<62>=7*=71667=38/>;:3&308616'7<;211%;9867'71,,4/*50-;#446;>4==-92*9*899961.36())/'<22;+9<0-0,3;/72924646,*45235/658>9=2,9+;9*4;4644172;:)<8/>=92:>79;8;2;:2*,)0;=<<>81>51=99;88/8,#*-35;939,/86=3:<:9/2999&297.,5.>:48><1;9<>*;48&7=7298%88:@-<53?@?4<<6$9;+-%:11.86?/A'0'2)74%'28=*89<<=28?>:>(584;%;--8:=25'>=<>:15:73:<9/>?2+:80+63,:243>>4 @rCer/1965/25_1643_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTTC + JK5KKKJKCJKFKKJGKHKKJKKKKHJHJGKKIH@GIAKJIKKHHKKKJKJEGIK:JGJKIFFCBKKJKKKIKK:KJKHHBJHKKJEK4I:KBEJIKKKKGK>KKIJHKFKKKK>KB@KEKKGJJHFKKHHKKJIAH?=JDKKHAHKHKKKJ8JKIKKJKGJKKFJKFIEFFHJIF>KJKKKKKKHFKIKGIKJIKKKKKJFJDKJKJJGIHGGACKFKJJIEKKJIHHKHKGKGJ:CJKKE>C>JJCE=GE2J@KI?JJKJK=KJI14BD>KJD>GJJGKHGGGKHIJHKHJFGKJKKJI8<@KKIDKKK8GGKKKJKGIJKJJGKKKDKJCKHIEKIJHBHDKI?JHKG8JCD?JBKKI=K9KKIIKKKJKGJKCKIKIGJKIGJKKJKJKKFHHKJAJK?HKKKIKKKKK?KJIKHJKKKHKIKKI>FGJKIFK)JAEKIJHKKKIJJKJK?KJ7JJKKGGKAKJJJ:JKKIFKKKHKKKAI;FEJKGIEKKJIFK>AGIKJJIKKIKKJJKKKKKAJAFIKKIKKKKKKIKDIKKFJKCKKKIIIKKKJKKKKKKJHHGGHGKFEF=JJKHKGKJ4KKJFIFKIKKKJJKJJ9KJHIJJKJKHIKKJIDKKKAJIJDKKIKK?IKJK;GKKKGHFEJ,HGGJGEGKKKAKJKKKKFIEKKKIJJKGKJKHJJKJJKKJIJKKKKJKH@KFKCKKKKKJKKJKAKIJ?IHKKFKHCKKKBJIJJCKJKKGKKJIG4KJ?HK7KKKKKKKKKEKKKDKKEJKKIKKKKKKKJAB5KAI7KHI6JKCIJKJJIJJ&7CJG;AJJDFKJIKGGKB?JI>KEI/1KDKBFKEKIDFIGIJEBKEJHK>?AHEKCKKKJKKKKGI4GJ=CKHCJDKIDIIKEKE@EKFIKHJJHKJIJKDJ>B;KKCKJKK7JJJIKJJKJKKJJKKKFIJ;KF;FGFJDKKKKKKKFJIKJFJKKJKJGKKKGDD6ADAKKKKK @rCer/1966/25_1637_CCS ATGGGGCTCTCTGCTGCACGCTCGGGTTCCTGGGCCCCGTTCCCCGGTTCCTGGGGCGCGAGTATGACCACAATGGCGGCAGCCACCCTGCTGCGCGCGACGCCCCACTTCAGCGGTCTCGCCACCGGCCGGACCTTCCTGCTGCAGGGTCTGTTGCGGCCGCTGAAGACTCCGGCATTGCCTCTCCTGTGCCGCGGCCTGGCCGTGGAGGCCAAGAAGACTTACGTGCGCGACAAGCCACATGTGAATGTGGTACCATCGGCCATGTGGACCACGGCAAGACCACGCTGACTGCAGCCATCACGAAGATTCTAGCCGAGGGAGGTGGGGCTAAATTCAAGAAGTATGAGGAGATTGACAATGCCCGGAGGAGCGAGCTCGGGGTATCACCATCAATGCGGCCCATGTGGAGTATAGCACTGCCGCCCGCCACTACGCCCACACAGACTGCCCGGGTCATGCAGATTATGTTAAGAATATGATCACAGGCACTGCACCCCTCGACGGCTGCATCCTGGTTTGTAGCAGCCAATGATGGCCCCATGCCCCAGACCCGAGAGCACTTATTACTGGCCAGACAGATTGGGGTGGAGCATGTGGTGGTGTATGTGAACAAGGCTGACGCTGTCCAGGACTCTGAGATGGTGGAGCTGGTGGAGCTGGAGATCCGGGAGCTGCTCACCGAGTTTGGCTATAAAGGGGAGGAGACCCCAGTCATTGTAGGCTCTGCTCTCTGTGCCCTTGAGGGTCGGGACCCTGAATTAGGCCTGAAATCTGTGCAGAAGCTACTGGATGCTGTGGACACTTACATCCCAGTGCCCACCCGGGACCTGGAGAAGCCTTTCCTGCTGCCTGTAGAGGGGGTGTTCTCCGTCCCTGGCCGTGGCACTGTGGTGACAGGTACGCTAGAGCGTGGCATTTTAAAGAAGGGAGACGAGTGTGAGCTCCTAGGACACAGCAAGAACATCCGCACTGTGGTGACAGGCATTGAGATGTTCCACAAGAACCTGGAGAGGGCCGAGGCCGGAGATAACCTCGGGGCCCTGGTTCGAGGCTTGAAGCGGGAGGACTTGCGGCGGGGCCTGGTCATGGTCAAGCCGGGTTCCATCAAGCCCCACCAGAAGGTGGAGGCCCAGGTTTACATCCTCAGCAAGGAGGAAGGTGGCCGCCACAAGCCCTTTGTGTCCCACTTCATGCCTATCATGTTCTCCCTGACTTGGGACATGGCCTGTCGGGTTATCCTGCCCCAGAGAAGGAGCTTGCCATGCCCGGGGAGGACCTGAAGTTCAACCTAATCTTGCGGCAGCCAATGATCTTGGAGAAAGGCCAGCGTTTCACCCTGCGAGATGGCAACCGGACTATCGGCACCGGTCTAGTCACCGACACGCTGGCCATGACTGAGGAGGAGAAGAACATCAAGTGGGGTTGAGTGCAGACCTCTGCTCAGCTTCCCTTGCGTGTAAGGCCTGTTCTAGCTAGGGCTCCCTCCTGCTTCCAGTGCCCTCTCATGACACAGGCTGCAACCCAGCAGAGGGCAGCTAGGTGGACATTTCTCCTGGTTGGAAGGGTCGGCCTGCCTGACTGGGGAGGTCAGTAAACTTCTGTGAATAGT + .,1;CECADAEBDB;:;71<48=/:>>FC::)790@DDB;G/C920;5?BEC55D9<6>299:65>0,<=<1><7@>9>@30;@<9:A2<@AADCC9=>B89/?A@=@A@A?AF>D=4;DA9@@5>+=7A9?,7;=;7DB=<:>?<B8A>?:<6=?C7=8BB2?<@8:7;@4:2=5;9<6@?@D8A?B@@>1B8G@DF:@=@A=E>>76@?EA>@=6972?C:4679<7A6=7%5.22>8<<:G?EA?4C>B99;':3?:15759E?@DD?;9;9AD;:<<6@@B68,CD:5E;=B=;DCB.GD/::<0@C?8B9>E:=A;@A-C@9>;>>;@??>:?,;>>F?A(=97=8:A<7D:=><=@&606+7987=C22B:D:>:;D?GC;??>:C866,:5;D:?@A(2:5@E?8B<:<@=27?BDCBEC:@1>.098'<7BDEBEF@B<8A:BC6D5<AA<>@3E>A?6=:5D:AG%332.?@0D?E>6;29>9=?A79$9ED53C6A9?2>@75>BC@>1=@;C97DD7>@A-??:C2:98<>>B;A;=>?99>;BAD3=D99:2@7?FFBAB?DF@CA9D*?45AA<;>EB?>@@B8ADF0C:BD4+@C-=@>B9B9?;-ACC=A@005)<>=>;C?899?2@5:*D8-=94*;:7?2B?@?=:>D:46AB8B;?;?:;=:9;7;5202;@6:7;48<>5:8<;AB@?;?>ACC=7CC7FE8DBB=CF9/=:2>?D,8<968?.=DFBEDA9GED18?@.A=<<512A;:DCC<5?>9>@@CFG>GA>ECB@2@EFAA<4DB;/DF=,?92;A2C?;;6>==B=?8?=@D96@:<>==)7/)88/;4>@?=CAD=:E;B?E?398>>G@;9:A<6@>D@89ECAC<@E>E:D?,8?AD;GCA&:>;8B<79;8AA:>';;0>B,CD:@6@:>E9B?CA;B;?E@EC+@?99@B7=?D<@:<@C;DCDAB@=9CABFC=BBA?EBBAC8;67EBG68<9;@C?>AB;05=6GG3@?>BA@5CA?<:FE@>C?B+?@D;C>=F=;2BDBD?EAH4F@B=8<4D>IDCCA>@BB:(<2BA=(B=ADGFD@E@G8>9A7@A=D>>BGIB>C?GB?FBD:BBH7GDAJE:HGG;FAE76DG9AEE:?>E=@A@5>??EDF7<@289<77'<-;>B@C;=6C=&0,1)1()&,/23-1*7.<38:<<::>0=7@>D=B5A?5:BCA63>FBB5;A;2>;=?;DAG3B>D;BD@;>A;@A@@BA9@ABA75@:5;<<@6A=C7A,@?@G:;8B>E@;@<84=84/8659&<:5984$+555/3'5::86092<7=;54388;>3><:<;4/:19:;:/:0:=5;383::275919:99;=9789928-9=3=-3;6:9:75+9>398=:8:::/998<1275;8@34,69340&:96A9=68>=;2;C=:=?3;9163=2?A4=?.@4@2::?36.3=0-5=@>4>54;5'=97143758/$:287<3;26:>3;=;%9773;$2.'67.3185=242<;:?A:9;;A@@->.,?@.57>==8:15=::>>B77=<<60?2747=94-677C6;8>9A=>7F=B;CB=D3DIABBC?D>EE56>6;*A'6?I.AG=CBGJGH97?++;669;?0FE;FDH@?F?C<69&AC77BE@HHFEIEG@E>@@AFD>B1B>B0:F;AC9A;<9D?@.?968:B+A89?/=2(=C>DA35;<&8>)3A;)+9??=5AB:53?C7:/*44:686?;:A>><;::4>>008<:4.;49*IF9F@A>EIEAA0C*7;I5CF5:7<:+0;:<;FEA48A;@C5>.C@?,69F><=CA7F:E4D?B@A$D9'D>=BE>:)=?5@?>DB>931A@=;?;279@013:@B*??GDCB7;E?A9==:;'=?-?D=?+BE78'72??C5:>:?>AF9FE3G@9>B995,4?9B:C:=FGEG2CB:CEG16:A?DB(2E:293?@:2*.;45B:D3:89/6;?:@DEA@0@<;>9C;:D:>;;A3@9:=7?@97.>8@5A>:B>A62@@D)3@:?::?=96#877<9,4@C@G9<#<598+79>2B=?9:6C7?D0::;&CA3:=4,@C@'+-;A943:=%8=BBC'4>A3:<7-?=>F?F<76':7>4?66=B%>6:C=C%2=5<8>=:=@=E8BA9A<5/948:97=CD86)<8A?AA:=?>@8DCA?<>;<9==94=E535>6>5>AD:?80:@E?.=4=32@B>A+9E:63A>E3@>@A7A;@:?9CCBG:@@+A,:CGFG:EC1><='64E7<349C8;541:::CA9FCDB99:@F3B*>?E315:6$6:;?965=7<1;D994095-12+)4<=3>;:@5?CC=8;7>80;@369@.G1BD<<4A?<3>E;A@<8A2<2A@G-8,5<+6>91?=:@CA@:;@CCB=DD7AB-;91:E?+=7?@4B9B>3?>C<<>A@>FC1@?%<909):B4CFB2BG?F=)=B>4?F>=%AE*BD=>=)@A89>(5-/?(61ABC@&BEEE0DEE>/?7-<>>?E,B @rCer/1968/24_1764_CCS ATGGGGCTGTGGACCTTGGCTTGGCCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAGGTCCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGAGCGGTCCCAGGGTGGACTGGCAGCCGGCGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCATCCCTGCCCTACTCGCCCGTCGGCTCCCCTCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTAATACCCTGAAGGATGAAATTGGAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAGAAGCTGATCCGGCAGGCCGGCCTTTCCACGCCGCCCCCACCCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAAACCGCTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTTCATGGCGCCCGAGTCGCTCTCCGAGACCGCAAGATCTTCTCTGGAAGGCCTTGGATGTTTGGGCCATGGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTGACACAGTAAGATCAAGAGTCAGGCCCTGGAATTTCCAGGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACCAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCCAGCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTTCAGCGCCTGGAAACCTGCTCACCAAAAAACCAACCAGGGAATGTGAGCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAAACCTCCAGGGCACCGACCCGCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAAGATGCCGGGCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCCATAGCAGCAGTCCTACGGAAACCCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGGG + -4-303330+013*/-110-/0*(%/$*,++2.2$-)'&,+.+(-./+//.*0/200/2/+1102&/1--01.112/21'#())-0(0010/002.,.,,0,0&*(,0+..-0,0001,/00-011/+***',.-(0/%-0+.1-1,11.1.*,+*()00),.00.-10,0/,/,))**,,-/01(+00+-+/,&'-0010+1.,(/)+1-12/*%-',/101--010-1,1.1201/&..//01)0(,,-.),+*,(*($)++))0++--,+21.0-1+1,/**%,1/21,-/00/+-,*(,./0.*+**)''(&(&''(*)))(+&--+,'-,2002200-,011*1/100+,,+.*.-*1+2*,-,--/**'*,,,,+21/()&&'+')').,-0+,*20.+,01.-#),,-'-,0+/)((/.+*,/0,102%,)/+,/*1/,++%'+,,(**,*.('**,,12-1/210100.*02.-2.).)-,-1+0+0.+*--0#'''-1201111+/))).,//-0--/0',,0),-/-,,-0-0.0'020-0**-021.0,112,/-01/*+.*-20-00*,+..1,+.&-0/)0110*1.-)-/.'/-(+'00210+11-../1*0/*&,*0),(.0)--1*01/,1(.*/,+0.-*,1/-)10+--/1/-,+.-/,*+,1.0.220-10111012--1-0-0111,./'00-20101/)-+%)0/(*,.+'.2,0*'%/*+$',0/-2---/11-/+,+$'*0..,2/-..0/*/.))1,.+-/)/+/1.-10+&'(*'+-1+0-+112,*1110,001,1-/11/2/%,*,10/00.1/*,)***1011,1*+('(,,/'*+*/.+',+-.+10%'/,,,.&,+,//('++++*+10/.*%$%)+,.,)-,.0-0.(,+0(1.2+*'/(./+%0$(**,+,$,+)*--.*-(*&$%(()&'(**'$(()-(0&-,)-+$-0*--+-.*+%)./,))'""(&"%)&$#$()(*')%*$')%%(*)+)#&*)+,'++*('#%$%''$&)+)+(*'*)())-,,)+,)((,())*&*''+,**((,+*,*,+'$)'%*%,%#('-,&,(&**&#))*,(*-)()),&'&&$((*+(.,%,-,+'(,*)+),),%()+((,-,-*%*%'((+,,(+()(++,'+'*,,**&*)'+'*)-))-),+--,'+*)(%&(((+--*-+*,)+),+(*#*),)+'&,,-(,-*'#%,.)--(*"&'+*,*,,+*+%&*,*'(%$(**,%)*+')$(&$%"'&%%&*(,'-,%)&&,(++*(.-,,&++*$+).('-',-,,-+()($$&'(%#+,+")+.---*-*,.-+$',,()$)+---,*+,+-&+.-&-(+-*,%#)((*)&&)-,(+,(,&,)-'(&,,,+*--,&'*,+$&&),'(*,,*.,&&'*+%,,##'())++(,*'*&(--++#(*)-),-*)&+*)-,())'(+%*'*+)'&%%$(%&((()(,+.+#('#&'(*--+*+,',+*+,,-----*(,*+*,,,,,-'+--+)-,,(,**,)-),%%#((-*-,(',-,-&+-*----,-+-),++)*(,'$'$'('((),+-),--+-+.-.-,+--),*'&-+,+(++(-*$&)$)+*)*#-+.-)+)&&-+&----,%'+-+)()(+,--+.-+,-(++),+&))),*-*-)-+,+&,,,+*(,(,--,+')'+,*,($((* @rCer/1970/1693_58_CCS ATGGGGGAACGCTGGGAAACTCGCGGCCTGCGCCACCATCTTGCTTTCCTTAATCTGGTAGGACCGTGTGTCAGAACAATCTTGAATCATGAAGCTACTAACCAGAGCCGGGTCCTTCTCGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAGCCTCAGGACCTTGAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATGCTCCTCTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTCCAACAATTTAGGAACCACCCATTTGCTGAGACTTGCATCCAGTCTGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCATGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAACCATGGCTTACACTGTGGAATGCCAGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTACTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGTTTGGTTTATCTGGTGTGAAGGCCAAATACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTCTTGTAGCAGAGAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCGTTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCGACTCAGCAGCCATTTGATGTTTCCGCATTTAATGCCAGTTTACTCAGATTCTGGACTCTTCGGGATTTATACTATTTCCCAGGCCACAGCTGCTGGAGATGTAATCAAGGCTTCATATAATCAAGTCAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCTGGATACCTAATGTCAGTGGAGTCTTCTGAACGTTTCCTGGAAGAAGTCGGGTCGCAGGCTCTAGTTGCTGGTTCTTACGTGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCTAACGCTGATATCATAAAATGCTGCAAAGAAGTTTGTTTCTGGCCAGAAGTCGATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGCTGTAATACTGACGCACACATTACGGGAGAGAGCTGAACATTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAATCTCTAATATAACATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCTCAGCTGACCTAAAGTCAATAAAACATTCTGCTTAGGTGTTT + >?@>E@1IBBHGIEFF@G?71=?1GFAICIBE4ID@D>J=?7A:AI6:>=FE:FBGC@?JF??D8DE5>@>;?F77AFID?C:DAE?=@I8;C*DD=@<;ABAC>FIJI@8EBAF*?EKD6CG1JKD?B*IG=EKHKI?FKBHIKIAC6?CHC<=D/EABFA@J>BDAGGAIHFBFBD>@B7DH@AH4GEF>@F7EEH=CCE4JFDHH/B<;DFC4>9@CGIDGICGIBI=EHG;=CH<@FBIHGBAE@:=87C=E?A2;<0DA=BHDA8D:D:9+BAG2??47E7;<;)GH;;FA02=*<7<6?6>:AH;=A@3EH:JDFAGDC;48=620B9;C);E8FE>H=?DBA?>3BH>;C@>D5FAA;=/BE>@>93GFD6B=D?B7C>DA@@=>4><;8;=AD;B?@?@?73==CBCB=7FEACD>EA>HDF,CCC6DEHFC7GG+HCH@@IFFJ>&;4E@8EFDEB2;96)6@@E@D>6./91,%7<->3?8AD?456>$8DCF@=>B@0:85GFFD@HI6EFE=CE:CIC>D.@=HGH5G?CH:>E@;??@>)C8F?H7@B626D589;?HBC?C?3;BF7>=@?'>H@B?>F@C=9@2FBH?@6;<.@88@@97=6B?C;BHD?<92<>?;D;BF8?GBB5AE26?8<484:@>68)6F=3>37=@9/86@;=B?4C>79A<7A<5)4=3@CB@C=BC??>=?CEBFCC?>4)&8567<6:?739:9824;?>68,@<62DA=B:>7;F=EB;=>56=659A<.G?FADCA2=8;97C;@;>@AFA9A1AECAG1;CBE;<>/>=>E=8BFC;A@E<>>:AD?>EG>FDBB@'51A:350=B==:8?B84=<<6?:=47A0;93'5;*4@.:>;6><7@;;-818<>=>7487>8178=@<:7=B?3796>;48;/=9:899%;=77:<9<,;:498:&6;<-:<=9=9:06%538?>762;9:>2;437-/:*>8519:07/22018/78:*:;7>7.4<;<=6=>9;7@:87450+1?B=A;=8>B20:A=7;<=76):27<6/:<;==<94;A>.@68;5:;$4=(9?C>=>>?:::<91;64-9?@4388-9A3BB?A7@@825=7?3=;@;A4<@6:/ @rCer/1974/25_2214_CCS ATAGCGGGGAAGGAGGAGGAGGAGCCGAGCGGGCGCTGCCACTGAGGCCTGACCATGGACGAGGAATACGATGTAATCGTGCTGGGGACCGGCCTCACCGAATGCATCTTGTCGGGCATCATGTCTGTGAACGGGAAGAAGGTGCTGCACATGGACCGGAACCCCTACTACGGGGGCGAGAGCTCCTCCATCACACCCCTGGAGGAGCTGTATAAGCGTTTTCAGTTGCTGGAGGGGCCCCCTGAGTCCATGGGCCGAGGCCGAGACTGGAACGTTGACCTGATTCCCAAATTCCTCATGGCTAACGGGCAGCTGGTAAAGATGCTACTGTATACAGAAGTGACTCGCTACCTGGACTTCAAGGTGGTGGAGGGCAGCTTTGTCTACAAGGGGGGCAAGATCTACAAAGTGCCGTCCACTGAGACTGAGGCCTTGGCTTCCAATCTGATGGGTATGTTTGAGAAACGGCGCTTCCGCAAGTTCCTGGTGTTTGTGGCAAACTTCGATGAGAATGACCCCAAGACCTTTGAGGGTGTTGACCCCCAGACTACCAGCATGCGTGATGTCTACCGGAAGTTTGATCTGGGCCAGGATGTCATCGATTTCACTGGCCACGCCCTGGCACTCTACCGCACTGATGACTACCTGGACCAGCCCTGTCTTGAGACCATCAACCGCATCAAGTTGTACAGTGAGTCCCTGGCCCGGTATGGCAAGAGCCCATATTTATACCCGCTCTACGGCCTGGGCGAGCTGCCCCAGGGTTTTGCAAGATTGAGTGCCATCTATGGGGGGACGTATATGCTGAACAAACCTGTGGATGACATCATCATGGAGAATGGCAAGGTGGTGGGCGTGAAATCTGAGGGAGAGGTGGCCCGCTGCAAGCAGCTGATCTGTGACCCCAGCTACATCCCGGACCGTGTGCGGAAGGCTGGCCAGGTTATCCGCATTATCTGTATCCTTAGCCACCCCATCAAGAACACCAACGATGCCAACTCCTGCCAAATAATCATCCCCCAGAACCAGGTCAACAGGAAGTCAGACATCTACGTGTGCATGATCTCCTATGCACACAACGTGGCGGCCCAGGGCAAATACATCGCCATCGCCAGCACTACTGTGGAGACCACGGACCCTGAAAAGGAGGTGGAGCCGGCTCTGGAGCTGTTGGAGCCCATTGACCAGAAGTTTGTGGCTATCAGTGACTTGTATGAGCCCATTGATGATGGTTGTGAGAGCCAGGTATTCTGTTCCTGCTCCTATGATGCCACCACACACTTTGAGACAACCTGCAACGACATCAAAGACATCTACAAACGCATGGCTGGCATGGCCTTTGACTTTGAGAACATGAAGCGTAAACAGAACGACGTCTTTGGAGAAGCTGAGCAGTGATTGTGGCCGCCCCCAGCCCCTGCTGCCCCAGCCTGTGTCTGTTCTCCTAGAGGGCTCCAGCATCCTCTGCTTCCCCCACCACGTTCCCATCACCCACCTCATTGATCCACTGACCAAATCCTTAACCCTAGCGATGGTTTGGGAGATGGGGGGTTGGATAGCATCCTCTTTCTTGGCCCTTCCTTATCCTAGGAAAAGAGGGTTCCTCTCCTTGTGTGTGTCTCTTCCCCCCACCCCTAATTCTTCTGCTCTGTTCGGGAAGACGGGGAGGAAAAGGTGACTTCTGCCCCCACCGCTCTTACCCCCACTGTAGTGGCCTTTGGAGATGCCCCCACCTCCCCCCACCAACTCTTGGCGTGTTGGAGAGAAGGGGCCCTCCCAGCACAAAGTTGCATTCCCCCCCCTAATTTATTCTAATTTATTAACTTCGACCCACCCTTTCTGAGCCTGCAGCCTTCCCGTGTGGCCTGGGGGCTGTAGAGTGAGCTGCCCCAGCCCCTCCCAGCCCTTGCCCAGCCTGGGGCAGTGGGGAAGGCTTGGGCGTGGCCCCGTTGGAGGTTGATTTGCTGTTTTGTTTCTTGTCTTTGTGTTTGTGTTCTGTGGTACTTGCTGAGAGAAAAATGTGAGCAAAGCAGAAGGAGGTGGGAAAATGGACCCAAACCCCAGTGTGCCCTGCCCGTACCTTTCCTTTAGTGGTGGGAAACCCTTATCTTGCAAAGTGAATGTGTCCCCTTCCCCACCCTCTAGTGTATTTCACAGAAAACAAAACCTCCCAATAAAACGGTTGAAAC + I8##$&'D$CKKKKIKHFJIKKJJGKJIIH@CJJIKHI=ICKJJK.IGKJJKKJHJEKIKJAJKCKJJKJ8GFFIKGKJJHHG8JJKIHKCKEKJIDGKGJKDHBFHE5IFJJEJJ>CCFIJJKFEJIJ:IH5H@8GI9JHKJKIFIIJFEJIKJDJFKJKCHKHFJI@HG(KFEHGBKKHKFIGJIJKH;AAIC?IKKKDKGJK=IFJHGDE)GDGH4IJHIGE;JIHJGJJ=KKIAHKKKIKBJKGJFC@JKBKJHGKCKJFHJHHJK;KJJDKJGCGGGIDJ/FEBFKFHFKIHHIIKIKGKKEKKJG?GJJKHEKJCCJJGJKJJGIIIEIAK;JJIKDDJKKGJI?KEDKJHHJHGKHJHFJHAIABHKEGJG6JK?HHHJIDI+KJKKHFFKKIFJDJJJKKJJI?KHHBKJKGJI>AIKIJKKJKCKDKKEKEKIKBKKJJKJKKIKKABKKIIFFKKKHKKKKKKGKGIGKKAHJKGKKIK4KDI;EIHIKIKHIJEKKJJKHFFH?>FIIHFDEAHGJB>GG8FIDGDKJIKKIIDE=DJGIGJBKJJIHJJIGJAJEJDFBKJ;HHBJH;GJFGKHFKIDKKGDK@EFGIII@HKJFK>FIFKGGEI?KKF=C?KKKGFCGEDIJ>IE8JKJJJKJCI@KJKK9KH9JJKJG9IIGBKBJJKIDFIIEAJE7JJJJFGHHDJKJCJJIKEIKIIFHFIIJHKIJIFEJHKFHGFK?HIKKHADDEBFJJGFA=JIHIFIKFDKIKHHHHKIEJGJ:FIKJJJGE9KFJ;IFJJGCHIHFJ7JIKHIJKJFIKIJKDKIIFIJJGHHKCIIJJJDIGI>AJKEDKKH@7G7IJHIBCIHKHKKIK3GJIHKJJ6DIHGJGHJKIKKEABHKFIFCBAHJHEIIKKGJGJJIHK:FHG4JHGHHKFJIEIIKJJJJ@JI;8GIB7FKJK?JHIJGIGAIIKKGIIIJIIKJKKJFAKCGHBIJKCD@GKKGFGKJJG?EE?JA@?7HHCKKJJIJGHKEKIKJAKKDFIEJKFKKFGJKJJJ=D*GHIJI3IJKIDIKKEBAJ;JAHGH8F>HJGKJFIHHIJ?KHJKI(IIGJIDKKGJKIHH,KIDGJJ2GGIJHFHIKJKKJ;KKEHKIJJ;KKKKFK8HKKIIICJ8JIKKJIKJHCHIEEJHKGHJHJCGJHKKFCFJI9GGJKKKHJJJGK5FEGJJKJDIHEHCCJHEJJGJE=2AIIDI?KHKJBJKKJ=KKEJKHKJKHAKF5KJGGGJIIKKKJKJKK@HBKHKKBDJDIEIHBI@GJAKFKIB2IJFFJK=KKKJ=KKI=KJHIEIHKICEKKJKHHKJHJCHJIII:GI99IJAIHCIKJKFGE>>IJDKJHHCIHK@FEKKH?KKCGKJJ@JGHKK6IIGJKKKDKJDJIJJKJ9IGJ*8767)12:947/(4<63-2*0-;/36<.-,-9819;75>27>=8<65'5:9+037837:3%*88,231(1497))01/527-8;58,;;6&$4583987-744.7->-=<*2/3;1/3/;6:83/04/0:,0.61,$4>.;0<;;447+:5:999:832/<<:<=8;572:3551:=)0:0192;6;49;88)1)801:799:2+96,;12;;<04&2)2>;5:+<58.87.4$669.:7:)/879>98-772;,<;68340./,>.4@-;?4<036+86=.52;>=A<.;9;?89/48*@649)58,89%?994<6%68==8&0>B8713<;==*:C:47?;@>>?::-;863,#22&:(72AA760;)9@56;939<@.9/:/<6:287>>.@9<25?=76.)B6=,<<:<;52C2808276:<>3;?;6;540.5155,4=61:/@B=@<;-6,@/<;5>AB@.?2<.<7<16.67=:9:4705?7@@.8,2>>/<+786<::@.<=?5:>37:919=,4183,;<8<<5?=7===7354101;:=3?:94=;AA;CC7>AA,<9/1;??4382:?<=;847:<>7;:84919<7?::;;A@A1;@9?039386792345&6)1(<*:?<+;%4167192<16;<<+6)55=7-=6527=7:;>9;>86?0B;<;<465(4897:/::732*;385,6B8B;?3<;7>5/063=7366:+<9<5>:3?==%:73/<=<89696A=<06=6>><;79:>/:87+61:%;?@/9;98:<<=<88.%8)05;1=;=2.7146,86+6'<5351=3-+;3/0(564&5,;<>@>?:?3:%-&3=:+4889->;:(5.==@2:=5=8>A<:==>7==4>84:>AA+806*9>;'*(8065;4%439(7?<900;)'?/9:=.9<;?64=9>5<9@2.7:4=464'7<0>9;9A2>=$;<16>958;-@;27,6;/4:9(24:>*?=8A97@A;=57:<>>B?C:<=B/;=?=<,<5@819=+2=79;8?=6098/;:46742>.-7+13420$-.0%53A?=63;30.25088.:<<998274(>8+8:3546514;+;6<1.672=4?@<:.<428?9/>?0:9::.459?=<>B:/<@BC;@AA@<9;5496>7=4??A>:49:-5126<;3;>A9=-<;<=?4?A/739:8?3498841<9<;4>8*'6?AA>?9?;C764:/94<:<86;<9;A29;=.528>%*,@7>4;:9=589=?<;5799=<.0:>>>=<3<;?>1>>A2AA7?>46)6;4=;AC@35<74??5;<@>@,>84<68@299=25=/96>;>'<>9A642;<95//@3:/A<<39:#8459=4?@C@??7C:=@/9.<:0?A>>:>@1>7=<8<<;*87?=<=7>94?>@8?4=C;>A4=,@=<695*;7>6=?0@/)448>.3C?6>@<@>7=;;9<4?@;?972>5B@6B>?BBC4AA?;>B?47<=>44=C=@>:<>:8@>@:7?BCCA6/A9;>:,>3<@55:6@??>94.3>;C7?CC@.>;:<779'9@A.><:;>/99@?<46@3=3>=2??@7A<>=>6=<:&C<;4;-<9:7A>:412*/3,0;->:A8;8(=?;69@>B6?::?7??7;249::4:< @rCer/1978/1842_59_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGGCCGTCTTCCCTCCATCGTGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + DFIJC98013.3/CBIKCIIGFKHGIIJ*E;EDAFIJDKJJJFGEHICKKFJJCIE?IEFH.?JJ?@I9@?97A%@I>IJHCIEIGDF>AIIHI=IIFHEECFADJAACFG7BIHCEBJIJGIBIEJG=GFHDG&G=GJCHCFDHIH)HI:KHGKJJGDD*F=4?FFHBIJ,BC@DJ(IJ9FJKGJKJ1IJJIIHG=CFK7G@DHG6CJC7I@K>AHD6A6DI1DHJGFAHBJD7BF=C>KFJGBEI/EGKDDFAFJJF?HGI4JJJFIIKHGCK@GHH*KKKKG5ADKHJIG.GJDI=G4?GGJGH?DIIHIKIEDGDGGJDIJ>CEFJKIAFIBIJJFIGCEI>IBJEG1II9E;J;IIGIJCI=BB99FFI-*J@H/JAJGHEACJJJ)IJIGGGKEJICEFEJ/KGJCFBJKF+DJHJE5HKHIHKJDJK?KFIBHJE=IG%:DF?GH)EEHIH*DE0F?HJI@DJJIIJKKCGIB7K/@HH1KDJ(FKHEGIHCF>HBDC@KFFDEECIHFG4FIKFHKJJJCCKGE?@HAJJGHAG@B?>D7B8?*EH7DDC?AHI=I>DHG9ICI-IHHAHFBEFKK?IHGI>?BF,A>JIGB.?DCFIHGAEIHDH-JH/HKHIHEBHD2HEJJIHDCKG>GFIK7JHID@F/JEIEKCK2H9KIIJGEJ6JCGI@ABGIAGB<8%HIFJBJJEKK@I@BH5KIIIDHAKBJJKJBCJHI:@AAIFKGJ;HHFCKIGDKJC;FKDEJHGFBKGKKEKFJK/HKFIHECEGEKEH:EFAA:HC?@IF9GFKFHGCK??E@IJ7GE8=F6EGHICK=C;HG?IH=GBKHEFHKK1HFBHH@7EGHIGE2IKFE@@JJ4IKK?EHJKKJDA'7FHJKCIEHAJ4HIKIIEKHHHD)>4D:IHIJJJIHDGGHD)IK3KKIH=EIHAG=?I,I4JHIEG@KE=CHKFIG5CIAFKHJAB@H?DCEAF?KAFI'EKKK;HFCFHB@FH+D%K@EBDIJJH.@AFKKJ8BCG@B'B;FJBGIGGJ;DEJJKDG.DKHH7C6IGJKKHFKKEDCEAI>FCHHH=HFGK9DF#DKE@J?JGJIJFIDGH6H5DBEJK9JJHA5C9>?JG74A?CB?G97> @rCer/1981/25_1978_CCS ATGGGGTCCGCCGTGTCCATGGAGAGAGGCTGAGGTGGCCGACCTCCGGCCCGAGGCACCGGGGCGCCGGGACGGCGAAGATGTCGGCTTCCTTAGTCCGGGCAACTGTCCGGGCTGTGAGCAAGAGGAAGCTGCAGCCCACCCGGGCAGCCCTCACTCTGACACCTTCAGCAGTAAACAAGATAAAACAACTTCTTAAAGATAAGCCTGAGCATGTAGGTGTAAAAGTTGGTGTCCGAACCAGGGGCTGTAACGGCCTTTCTTATACTCTAGAATATACAAAGACAAAAGGAGATTCTGATGAAGAAGTTATTCAAGATGGAGTCAGAGTATTCATCGAAAAGAAAGCACAGCTAACACTTTTAGGAACAGAAATGGACTATGTTGAAGACAAATTATCCAGTGAGTTTGTGTTCAATAACCCAAACATCAAAGGGACTTGTGGCTGTGGAGAAAGCTTTAATATTTGAAATCTCAGGACTCTTCTGGCCGTAGGTTCCAGGAAAGCTCGTGGAAGCCTTGTTGCTCACTGCAGAAATCGTGTGACTGTCATGCTGGAAAATAAAGTGATACATCTTGAAAATGAAGCCAGTGTGTTGGATTCCAGAAGAAATGATATTTGTATTCTCTATAGGGGACAGAAAGTGAGAAGCCATCACTCTCTTTGGATCATTTAGGTCTCTTGCATCCTTTGTTTTAGAACCAGTTTTATTAAAGTTGCCTTCCTGGCTACCTGTTTATCCATTTCCTGAACTGTGTGCACTCCTTAGATCGCTATTGAATGGCTTGAACATCCCTCAACATTTCTCCCAACCAGATCGGCGACTCCAAAAATCCGAGACAGGACATCCTGACTGCTGGTAGTAACATGGTGGTGCATTGTTTTTCCACCCAAACTTAACATAGCCTTTGTATACACTTTGATGAAAAATTTCATTGTCAGATGCCTCATTGCGTACCCTTTAATAGTACCAGGCAAAGATTTTCTTCAACTATAGTACAGATTAGTTCTGAGTGATGGTATCAAAAGGTGAGAAAGACGCCATCCATTTGTTTTTTTAATCCATTTTTTTTGCCACCCTATATGTCTGTTCAGAGAGGGGATTTCAAGCTGACTTTGATTCTTTTAGTTAAGGAGTCTCTTAAAGCCATCTAGCCCACCTCCCTCAATTCCCTGTGTGAGGAAGCAAAACCCCAGAGAAGCCAAAGGGCTCCTGTCCACTCCGATTCCACAGGCCGGGGGAGAGTAGGGACTCTCACCCCCCTCCCCTTCCATGTAGGTGACACATGCTTTGTCCTCTGAGGCAGTCAGTGAAGGCAAATGGTCTGACTTCTTTATGTGGTCAACATTTTGATAGAATTTCTTTATAATTTGATAGAGATTATATTGTTATTGTTTTATGTTGAGTGAGAAGAATTTTAAAACCTTTTTATGTGAATTACCATCTTGTTTCTTTCACCTTTGAAACAGTGGATTGTAGCAGAGACATTGTAGCAACCCAGAGTTATGCTTTTGGAATGTGGTCCTCACTGTGCAGGAGAACATGGGGATCCTTTGTTAACATTCCCAGTGTGCACACACTTTCTGCTTCCTCCGTCCAGTTGCTCAAGTTCTTAGTATTTTAGCCTAACGTTTTTATCACCTACTTTTCTTGAAAAGTGTTCCTTTTGTCACTTAGTTACTGATTTTCCTGGGTTTGACATACTAAGTATTCTATGAGATGATATATATGCTTTTTTTTGAAAGCTAATTCTCATGAATTCAAGTAGCTGAGTTCCTTTGTTTCTTTTATTCACTAAAGTAGCTGGCACAAAACACAGAAACCTAGAGCAGTAGTTTTATGTCAATGCTCATGAGTTTGTATCGATAATATAATTGTTGATCCACTTATAATTCGTGCAATACTGTATGTATGTAGACATTGAGTTGTCAATTAAAGAAAATGTGGCCTC + HE8KKJG>IJBHEIE?IKKKJKKJKIKCEJIGKIJGIK=K@JJKH@I?I7KKIHDKHAKH5IIKFJGJ:KHGJGIGCGKJJ@IJGJIHAJJGJEIEFJKJKGKJIJIKFKKJFKKJKKJJGIKKKJ@KJIJIH@EBE=JIDIKCKFJI;HJKIDFHDIIHIFK?KHBDE;FJKIJCGJ?KJJEC?.@DJJK>K@KKIE;KHIJKKJJHK7F1IIAKKKHIEKJ@KIJJIHKEKKKF@FHHJHDK>-GDAJJHD?KIHAEEJJJJ:FII?IHKJKJJJKKI7IKJIKKIKJHKJIKJEIBKIJKIAJICKJGKKKIJJIKKHDGKKGKKJ>IKKJIJIFJJKJJKKHHKCGKHHGHF@HIJJKJKIIJIHKJJGJKIEI/IHJIIFKJHKIKJJKGE?FGKK$DGHKEJ@@KJCJK?KKJKEIHKKKKIKKFJ@KKDJKGJ?GFKJJC6KKKKIJ>KIFKKDKGJJKJDJ>EKJCKKKKAKJKJDGJCKJKJJJJKGKGJIJKJIJHFIHEIKJIIJJKJKJJEKKKFIKJIKKKJKKKKHKIKKCIKJKE>KKKJKIKDJGKJKFHKKHKKHJ>HCFIJEKJJIKKKIHE=FKHAKKICIHIKJIKKCBKJGJDJHDF5DKIFIE@JEGKIJ>H1IFHKI9KKKEGJKKJ;HKGAGIGIKJKKIJJIKAJ:KIDF6KKKFGJH0KKEDIBJJI5JFKHIJDI?FBIDIFDI-@FGFJJ;KAKJDHHJAKCJIKKHIJAKIGJJF>88:.5C1B7=F>;6@=C6>?6CC+A*B74B:FG9>@@&:8F4@@:-9=5&8AE:A<*C7?>499&BI8HE4C:+/I.CKDIJBE0?H46>,I<>7GED=E4E,=17F5C=D>D?969A>EHJ,FE?GB'GK7I3?@H?8J5413I)FGH.D:KGE;/;K;-==.BG8K2EJFHIEG6HB+B8KJDA4D1>@:-=C?B/@:@A,DE64?FBFHKIF>GGIEFJJ?EEG?F:DE.8@FI&C79D8F'5A%'<@G*8C<$KKH>I*HCFBDBJKI9=FJ'2>53?GK:DA97E%J=JHJ?B?CA@GKBDI1G(FIC;JI6KK>;J>>;&7@-+<74'G=?C)E-DGACE;5FH8A1B1@9<B*??*B/F9F@*/CA+&FEI0J?F@:&=85;;@=-52,H8.52>7/FD&'=';:BE:BAECC)>C @rCer/1984/25_2059_CCS ATGGGGGAGGAGGCAGGGATGTGAGGGGCGGGGGACAGGACAGCCGGCCTTCCGTTAAATATCTGCTCCTCGCGCTCGAGCCTCCCTGCCTATTGTCGGGCCGGAGGCGAGCCGACACAGCGCCAGCTTGTCAAAGGGAAGGAAGATGCCGCCCTGCACGCCCGCCGCGCACAGAGCATAAAGAACCTGCGCTGAGGAGGCAGGAGAAGAAAGCCGAATCCATCTACCGCCGGGAGCCAGAAGATGGAGGAAGCTGTACCGTGCCAACGGCCATCTCTTCCAAGCCAAGCGCTTTAACAGGAGAGCGTACTGCGGTCAGTGCAGCGAGAGGATATGGGGCCTCGCGAGGCAAGGCTACAGGTGCATCAACTGCAAACTGCTGGTCCATAAGCGCTGCCACGGCCTCGTCCCGCTGACCTGCAGGAAGCATATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTGGATGACAAGAACGAGGACGCCGACCTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAACATGACAGCATTAAAGACGACTCTGAGGACCTTAAGCCAGTTATCGATGGGATGGATGGAATCAAAATCTCTCAGGGGCTCGGGCTGCAGGACTTCGACCTAATCAGAGTCATAGGGCGCGGGAGCTACGCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTGAAGAAAGAGCTGGTGCATGACGACGAGGATATTGACTGGGTACAGACAGAGAAGCACGTGTTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGATTACATTCCTGCTTCCAGACGACAAGTCGGCTGTTCCTGGTCATTGAGTACGTCAATGGCGGGGACCTGATGTTCCACATGCAGAGGCAGAGGAAGCTCCCCGAGGAGCACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCCCTCAACTTCCTACACGAGAGGGGGATCATCTACCGGGACCTGAAGCTGGACAACGTCCTCCTGGACGCAGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGCCCTGGCGACACAACAAGCACTTTCTGCGGAACCCCGAACTACATCGCCCCCGAAATCCTGCGGGGAGAAGAGTACGGGTTCAGCGTGGACTGGTGGGCACTGGGCGTCCTCATGTTTGAGATGATGGCCGGGCGCTCCCATTTGACATCATCACCGACAACCCGGACATGAACACAGAGGACTACCTTTTCCAAGTGATCCTGGAGAAGCCCATCCGGATCCCCCGTTCCTGTCCGTCAAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGGACCCCAAAGAGAGGCTCGGCTGCCGGCCACAGACTGGATTTTCAGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGGGACTTGCTGGAGAAGAAGCAGGCGCTCCCTCCATTCCAGCCACAGATCACGGACGACTACGGTCTGGACAACTTTGACACACAGTTCACCAGCGAGCCCGTGCAGCTGACCCCAGACGATGAGGATGCCATAAAGAGGATCGACCAGTCGGAGTTCGAAGGCTTCGAGTACATCAACCCATTACTGCTGTCCACCGAGGAGTCGGTGTGAGGCCGCTGCGTCTCTGTCGTGGACATGCGTGATTGACCCTTTAACTGTATCCTTAACCACCGCATATGCATGCCAGGCTGGGCACGGCTCCGAGGGCAGCCAGGGACAGACGCTTGCGCCGAGACCACGGAGGGAAGCGTCGGCAGGCGCTGCTGGGAGCAGAACGGTCCCTCACACCTGGGCCCGGGCAGGCCAGCTTCGTGCTGGAGGAACTTGCTGCTGAGCCTGTGTCGCGGTGGCCGCGGGACCCTGCTGAGGGGCTGTCATGCAGTTTCCAAGGTGCACATTTTCCACGGAAACAGAACTCGATGCACTGACCTGCCCCGCCAGGAAAGGGAGCGTGTAGCGTCCTGAGGAATAAAAGTTCCGATGATGT + KKKK5KKKKKKKK9KKKKKKKKJJKKKKKKKIKKKKCK9KIJKKKKKKIKEGKKKIKKKKKK?KKJKKKKKKJKKKKKJKKKKK&KKKKKKHKCKKKKEKKKKHKKKKKKKJKJKKKKGKKAKHKHIKKKJKJKKKKJKKKKKKKKKKGKKKFKKKKKKKHKK>KKKKKKCKKKKKKKK=KIJKKKKK=KKK?KIKKKKKHKKKKJKK>KKKKKKKKKKKKKKKKKGKKKKKKCIKKHKKI?KKJKKKKFKKKKK=KKKKAGKKKKKKKIKKJKKHKHKKKKKFKKKK?KHKKJKKKKFKJK2KKKKKKK?KKJKKKKKKKAIJK>KKHKKKKKKKKKKKKKJKKKKKKKKKKKFKKKKKKKKKKKEKJKKKKKKFKHKKKKKKKK;KKKKIKKKKKKKKKKKKKKHKKKIKKJKKKKKK@KKKKJKKKKGKKKHKKKKKKK>KKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKK2KKJKKKIFKJKKKKKKKKKEKKKKKKKIKKKKGKKKG:KKKKKKHKKDKKKKK9KKKKCKKKKHKKKCKKIKKJJJKKKKKKKJKKKKKKKKKJKKKIKKKKKKKKKKKKJKKKKKKJJKKKKKKKKFKKKKKKKKKKKKKKKKKHK4KKKJKGKKHKKKKKKJKJKKKKKKKKKKKKKKJKKKKKKKKKK?KKKJ>KKKKAKKKK?KKKKJCKKKKJKK:KK=KKKKKKKKKKKKKFKKKJJKKJKIIKKKKKGKHKK=H5KKKKKKKKKK>KKKKKKKHKKJKKKKKKKKKKKKBKJKJJ?KKCKKKKBKKKKJKKKKKKKKKK,KKKKJKKJKJKKKK4KKKKKKKCKKKKKKKKKKKKKKKKKKH2KKKKKKKKKKKKKJKKFKJKKGKKKKJH?KHKKIKKJKKKKKKKKKKKKKKKKHKKJKKKIKKKKKKJI@KHKKKKKKKKKKKKIKIK;JKKKFKKKJKKKKKFKKKKKJKKKKKKKK(KKKJ>GKKJKKKKKKKKKKKKKKKIKKKKKKK>KKKKKK9KKKKKKKKKIKKGKKKJJKKKKK@KJKIKKKKKK&KKKKKKKKKKKKJCKKJKKKKJKJKKJKKKKJKKKKKKJKKKKKKKKKK;KKKIKHKKKKKKKKKKKKKKKKKKKKFKKJKKK=KKK8%IKKKKKHKJKKKKKKKKKKKKKKJIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKKKK9KKKKKKKKJJKKKKKJKKKKIEKKJIJKJKKKKHKKKKKJKKKIKKKIKKKJKKKKKKKIKKKK:K.KKKKKKKEJKKKKJKKJKKKKKKKKKJKKKKKKIKKKJKKCKKKKKKKKKKK;KKKKKKKKJKKKKKHJK9KJKKKKKKKKKKHKKKEKKKGKKKKKKKK,KKKKKKKJKKKKKKKFKKKKKKKKKGKK;KKJKKKKKK6KKKBKKKKIKKK3KKKKKHKBKKKKKBKKKKKFGKKK%KKKDKKKKKK8KKKKKKKKKKKJKKKKKKKFKKKKKKJKKIKKKCKJKHH+KKKKK;<:A?A9><6)38;8='77>?:-==><7<997A9&;;<>;<<7<><9=?>A9B<<<4=>A;>8A<:>0>;7085;;1:/8=1=>>=A>@7?>;>99.<.><87<6<<>90:>??;==8>7?2::=:B7=;>;?9A?9;;7?9=<56?>@<=B'@6:;9':7=?A?67::4=2==;0A6@<-&789:@9<:=9:<58.<8:?:;=973926682??C@<8AB9>6@@;8>=:=;A=3;>@9@>=<>=?46.=692=-@B?,AB<9C;A;>@<<<>@36;7488?3>.6<;=@@:C@=?>B?>=@A=CB@B6@3A==BC=?A?B=<=<;5:695748<:55?:>=80><;A@+6B>>40<=?;A+;?9=;@B=4=46;B<6=?:@>=6-5?6@:>>;A?;A=A<,8/BAA4@?A?C@>:4$@6@;8:>:2AAA=&>:2ACB=0<>B@::CABAC@;1:@A9<>?B/@69>B?A7=3.><@@>?19?,?<2@@3B>0AACA?C?94+A>=@>CA19):>>/?:13:6AB:;7@?A6B99C<>>A@>7?@>=5:>>=6C>?@.<>=9?<<>6/80;3;477:98'8;@>=9A9>8:>=;6;:A8770A3?;C<947,;787<8?8CB<9/<68?;4AAA@?A=<:7=@>@B>?>C@99>;=A9;>>?6<>@8>;67==4*63:<>4.=9?<67>;????=AB7@@A;C?@>?AA?87>-:=C;=>A2@>@?7>5102:;:585$61:1+927>32<48797:6780::5=<93>8487>:9218:64/=;=:3:7>9?)04506=3<<<3(8::7:35<,/;;.7:4=7?<48-:889:*9>7>;;=>>:=1;9;77=9<=<8;+39824-:1681<8;;;??;;86,008?7:99>;>8:2=78>58=<5<'26:9996+.(7762+=:><6598916>88>;;==753;:>>:<58928:8>:,>2657855-;6==<77>1=3=;5=9:;==,88/32298%<;26=79:8736208:7:299?>=>:=<<<;;6<:<;;7;=99934;4;74,4193365>:7.:<&6755/,:8<::3;739>8:>93;;>;;=>7-=;9%68126?0;>>93:67=::>2758:>7:=>=3=9996:>1/5:;2<9>:8489>=6;-<8530#2489:7=7<9;:;5:/==<2=>48+;:>888;>;5<)90564>=;<8=*;9=86:7,196/957;;866382<;>78'7:7.1<8:6=:;567:41$;65;:8=8*75*:>:6:?77>9<94<>;=86':2007:;>=>>2<;559=<6280=85:>;<>?>3>;(::>=:?>24>9=883=>=;8;6787:9097<8:6=)9;;9?:1.24<<>;;&56327:645436;:=39<:;*6918:35>?;9>=<=>9;?=);;4.25/;>?>9=>>8;:094:>;;;8?>62%;=<8>+=<<::>8:=;<5;=<:8+;=<614=;:>:49.:78>5>998:6<:99<:;6;2->==:,8;<:<=8:7<76:=:<-15;>5>5=?;?=?5:;>7:;>9?>6836;<<<<;><889<9=><<9<>?97=5<6=5>-97;<&558;;;=7?<<;<>1848<<155;3?3:86;<9977>7<>;0:;;:<.49;;8<;?7?65:8/<<8=*;;;;;96>2? @rCer/1991/2905_72_CCS TGCTCCTGAACCTCTCACTCTCTGATTCAGGCTCGCTCCAAGGACCAGAGTGAAAATTCAGGATGGGGTTCTTAGGTACCAACAGCTCTGCCAAGTCATCGGAAAACCATAGAAATAAAGAAATTTCCATCTGAGGCCTAGGTAGGGATCTGCCTCCGGTCCTAAGGGTTCTCCGAACAAGAAGAAGAAGCCAAAAAGCCACCGGCACCCCCGACGCCCAGCATCTATGAATGACATCAACTGACTGGGTGCAAGGGATAGGCCTTTTGGCTGAGCTAGAGCCCTCTTCCTGACCCCCCACCCAGGTGCATTAGCCTGCGCAAATGGACGGCTCTGCTGGGGGTTGGGGCTTGGGAGCTTGGTGGGCCAGTCAGGCAGAGGATTCCGATTATGCGCACCCCTGGGGGAGTGTCAAAGTCCTCTGCAATGGAGCACGACTTCTCGCGTGCAGGACCGAGACCATGGATCAATATTATTGGCCGTTGGACATTTTAAGTTTCGGTGGGGATGGGCGTTTTCCTTATTTATTTCTGTGAGTTTATCTGGATGTCCAGCGTAGGCCAGGGGCCTGATGGGAGCGCTGTGCCAGGGCCATCTGCCTGCCCCCCACCCCAGGAACTGGACTATAGCCCTAGCTGATGGACGGCCATGTGGTGTATCCCGGTGAGGCTGTGGGTTGGAATGCTGAGCCTGGAGGGGGCCTGCCTTGGCCGCACCTCAGCAACGTGAATGGTGTCGGTGCTGGAGCTGAGGGGCAAGGCTGGGCATGTTCTGTCCTGTGTGCAGAATCTCTATCAAATTGCCCCCAGTCCCAGGGGATAGGCAGGCACAGTAGTTGCCTGTTCTGCTGAGCGTGGGCGTCCAGAACTGCCGCCCCTTCCTGCCCCTCACAGTGGGCAGCCCTTTCCCCTCAGTACCCATGGGCCTCCTTCGGCAGGCAGGAGCTGTCCTTTTGTTGTTGTGGTGCCAGGAAGAGGCTTCCAGCCTCTACAGCTTCAAGGAATGGGAATAGGAGGGTAGGGAGATGGGAAAGTGTCAGAATTTCCTCCCCCTGTCTCTCCTCCCCCATGACCAGGGCTGGTTGAGGAGTCGGGGGCGCCCAAGGTGAGGGGACGGTGCCGCTGCTTTATTTGAAATGTTTTCTTTACCTCTATCCCTGCCCCAGGAAGGGACCAGCTTCACCCTCCTGGGGTGGCCCGTTGTTCCTCTGACCCATCCTGCCCCACTGGCTCCTACCGGGAGCAGCCCAGTTTCCCAACTGCTGGCTTTTTCCACCCCCTTCAGCCTTGACCGAGCTTCAGTTTTCTCGGTGGTCCTGCCTCCCAAAGGCCTGCCCTGTTTCCTTCCTTAGCGCTTTTAATGTTATTTATTCTGTACTTGTGGTTTTAGGGTAGCTCTTGAACGAAATCTCTAATTCTCGTGCCTCTCCCCTTTGCTAGGAGTTCGCGGTGGGAAGACGGCGGTGGCCTCTGTATGCTCCGGTGTTTCAGTGGAGGGGAAGGTGTGTCATTCGCCCCTCTCTGGGACTGTCATTGCCAGTGTTGCCCACCTGCCTGGTCCTACAAAAACCTGAAGAGATGTACAGTCCCCCTCCATGCGGGGCACCACCACTCCCAGGAGGCCAAGCTGGAGCTGACCGCGACCTTGGGCTGTCGGAAGCCAGAGCTGGACTGACACGGTGTGGAGGGACCCTGAGCCAAGTTTGCTCTGGCACTTCCTTGGACATGTCCCCTGCCCTCATCCAAGAGGAGCACAATCCCACAATTTGGGTAGCTATGTACCCAGGACCTGGTTGGCTGATTCGGTTAGGGACCTAGAGGGTTAAGGGAACAACAGGATGGGGCTGCAATGCCCTTCTTGGACTCCGCCTCTCAATCTGGGCGTGGTTCTGATTTTGGCTCATGCTCTGGTTGCAAATGGTTTTTTAAACCCAAATTGTTGATTATTTTTTAAAAAGCCAAACATTTTGGCAGGAGTTAGAATATATCCGTGGTGGCCTGGGCGCTCTTCCGTTATTTGGCCTCCGTAGCTTTCTCCCTCTGGAGGGGAGGCCGGAGGGAGAGGAGGATCTCAGTCTAGGCCTCCAGCGCTTCCAGATGCAGTCTGGGGAGTGGGTCTGAAGGTTGAATGGGAGGAGGCTGTGCGGCCACTCTCCTCTTCTGATGAGAGCAGCAAAACTGAAGCTCAGGCACCTAATATCACGTCTTTGCCTGTGGCTTTCCTTTTCCCCTTCTGGTTGGAGGAGGAAGAAGTGGGATAGTAGTTGGGATGTTTTCCACATATATAACTTCCCCATCATGTTCCTTAGGCCCGCCATCAGGGAGAGCCCCCTGCCCAGGCTGATGGTAAAGAGATGGCTTTTGGCCAGCAGGGATCTCCTGATGGACAACCCTTTTTCCTTCGGGAGAGAGTGCCCCTACATGTAGTTGAACATGGGCTGCTATGGAGCTTCCCACCTCCCCTCCCTTTAACAGCAGGCTGGCTGTGGGTTTCTTATTCCCATCCTTTCCCACCCCGGCTATGGTGTCGTCCGCCTGTTCCTATCATGTGTCTGAGTGTGGTGTGGGGGGTGTTCTGTACTATATTCCATGGCCGGTGGCTTTTCCTTCCATGCATCACTCCCCCCGCATGCCAGGCACCGCCTGCATTTACCGATTGTCTGGTGTCACTTGGGGCGAGGGGGTGGGTCTCACGCTGTGTACCTGTGGTCTTGAGATTTTCTATTTTTTTGCATAATGTAAATCCATTCTGTACAGGTAGCATAACTTTGTTAAACACTGTGTATTCCTCTGCCCCATGGCTGCTGGATGTAAATAAACTGCACTCCCGTTGG + '&()&#%()&(),++),,%+((.+..)/.&',--"(.-,,,.$&*&"-.,.--(&%,#&+,'+'*#'%'')##%)'%,'+++-*.-)-,,'&"),$'&"+-)',*-.+&$-.-(,#,'+*(%++#"'+..&..+-&*.,(.+-*.+'-"./.+--,-),#-..-,.*%.#..-.&-*+.../-.'-'-+/,--+,&./,.//-/,./)+()+'.-.'*%())-&-..*-+-./*/(//,,....-%'('*..,,-&)&.-.#+.-')(,",-.-./$..&.*#%(,&),-./)-+()#+..,,,/+.,.)",#.,--/-/,-$.//&.+-%,&+..--.)'%(-'-*%+(*')&*(-..%&,-'+$*-.)#..&'-&#'.(//*.-*&/**...'$.-+*,--)$$%--/..,-+.-.&-..'')'*.&,--./....+$.-%.*#'/...).-."..'(-..()."/'#...(..(.(%-..(-#-..#,",.-,.(,"(-.-*(%-",&'&*.'++-.%*.'*,/.$,/./'/-./*,/$/.++&,'.--.'.#-..)+-..*'(+-.''.,$)#,,.,...')&--'((,.#...*.'.),('*+.,%++.%'.,"-.),-./%./+-,.-//./$".%#+.*&"...&.)..%,#*++.+#*+-%&+.-&-**(,(($".-...',)-.(')%')%+../+"-'.&+-,-#.-./&.,)-+.-/++.*'",.)/,//.&)*'..&-.%,*#-),-$,',)(&...#'..-.+,./..//..//,.'",,'.-&.++$.(,%+'&(','%.+)((#.+/%.-/+.(.+,#-.($.(,.',$.///)..-&.'**&-%....&-,.+/,//)+%,,),../+-(*..//+/$&-*../+-,.%*.+**.+.--$.,+-(-+'),,*,)%&-(,).&-//*.+)./.--.)+,'.(--&&%&*(+,.//*.++.)+,-$-.//+,.,&..*/)&,--'.*/./.,(.-#--$.-')--('%.-*#,(%#&,.'..-)..-()+''#)''&*(..%.-.&(,(("&),&.,.-/.')../%($/+.)-..#.(#('+#**+--.+.-,'('&)-.+-.'+,-....*--.(+-$'-...(*%-%#',-*--"&*-,,..*%&&'/).+.)&)+,..'"*,',**))*).'#%#-*)*+-#+&')((.-.."+,*'&#%'(*,&*,-..)&#)),,--&*&"(-$*'***''%%+**,,*.//.-$.-%$#)*+,*%)&,.)..$,-.(/+../$/./*--.'(++.'(#++'%),-.-+-.'(()*..%+--'+,).(.*,+'.),-.%-.,/,.),,/+%,,*.'*,..)../()-/*../,.()$,,'"#---*-($.-+"-.+-..",&',-$---)&&),.-***'+-#))&-&))..$,*.&.*(.+(&(,(-.*$,*./+)+...--#&&-,,,.+"+-'+.%.--'(*##%))+(%'%,'-..(#/$()+(-.&*.&&-%..*&%#$.+&(,-.-$/)+*+*+.'-*-%+-,&#-+'$*&$+,*/),-.-&%.--+#,,*(')*))+-..&-(&)--.-.,&&(.+,,..*..%++-#/-.(+",+&...*/+-..&-$''(...#(/*#+-*'',-'(-,''(..../..,#+++%#((&.-+,-//)--,-.#('.....,,..-/*&--$/*.'&/.),#*&+/*&-..+/.--.-),(-.."+#,/.,+//.).(,.,)../...+/.,.*,//)-.%*.&'&-$-,.$,#((%.(-.&&)-*(--.,+)(%)+.*(/,.-#*//+...'+),..)).//*-+.*."),)(,-,,.#,+-.,)$$#,,&&%--.,/)../..))#.*&..-..."-*,&,(..&--,/+.(++,+.(-,)+'$..).,#&*.)--(+#%,)(&',.(-)',.*+()+%+)..(.(#,+.*,.,&+.--#..+",)*.'/'(&-,&&-(*-/.)"*$'.*+-,,,,,*&*.)++.((+--'-&,-)((..+#,.),,&&-&'&-.&+..,....#%$&$&-.-*+..-..&),-./../+./,#.'+*'.,)*'%"...,,.*&#",,"-)''+%*.).)/.-".(((.-...,-%..*%..."&.-#'-.&)($'(,*+#,'...+.(-'$-.,-.-"/('#-..(#&-/./*/,..%.,,"&&%((((.%.-/+'))'&.'.&($,.+-.*&,**#...../(.,(&(--#&--(../..##"--//*.,*,//"$-/.)(..%".)''%(%)"(-,%+%-,))(*%+,./*#**.&--&,"/+-.*../.-./,-.'%'.*('-..&.('-",.&/-.'#.'+--%-*+-$',*,)-(-%,(...-+.),&,(*.&,-.-,-%,$'++.-".)(&#/-%)#.)().-$,**/...,*%+()&&-%*&+(+'*&)(-,-$%-'-,+)-('()#&-)-$+.&,+&'#-)))-*)+.'+-,#.#)/+./.+.(,*..*%,-*,//.*-#,(.*./-*.*-(.-..+''%,/-.)-.-")%-,"+'$-*-,-$#(,%,.*&-#$)(,&,.&.,.-'*+).-%,)')*&(,'&'&)+%(-,,/+/++%-,)%,+.&-.$/#..+,$,.*/*/(-(%)+'*,(&'($)*(#-,././.%."),#,.+.*,),),#/.(.-(&)(,-,%#.*+)/.///#/'*.)",+',.)/././/./+.,+&#.-+..%,.#,.+-///&..,..+*.-(,./)-(+&..*...--.%#/-.-*-,/*.+..*.%-%(,/.(-( @rCer/1992/25_1983_CCS ATGGGGACACTTGCAACCTGCAGAGGCCCGGAGAACACAACCCTCCGAGAAGCCCAGGTCCAGAGCCAAACCCATCACTGACCCCCCAGCCCAGGCGCCCAGCCACTCCCCACCGCTACCATGGCCGAAGACGCAGACATGCGCAATGAGCTGGAGGAGATGCAGCGAAGGGCTGACCAGTTGGCTGATGAGTCGCTGGAAAGCACCCGTCGTATGCTGCAACTGGTTGAAGAGAGTAAAGATGCTGGTATCAGGACTTTGGTTATGTTGGATGAACAAGGAGAACAACTGGAACGCATTGAGGAAGGGATGGACCAAATCAATAAGGACATGAAAGAAGCAGAAAAGAATTTGACGGACCTAGGAAAATTCTGCGGGCTTTGTGTGTGTCCCTGTAACAAGCTTAAATCAAGTGATGCTTACAAAAAAGCCTGGGGCAATAATCAGGATGGAGTGGTGGCCAGCCAGCCTGCTCGTGTAGTGGACGAACGGAGCAGATGGCCATCAGTGGCGGCTTCATCCGCAGGGTAACAAATGATGCCCGAGAAAATGAAATGGATGAAAACCTGGAGCAGGTGAGCGCATCATCGGGAACCTCCGTCACATGGCCCTGGATATGGGCAATGAGATCGATACACAGAATCGCCAGATCGACAGGATCATGGAGAAGGCTGATTCCAACAAAACCAGAATTGATGAGGCCAACCAACGTGCAACAAAGATGCTGGGAAGTGGTTAAATGTGCCCACCCGTGTTCTCCTCTGAATGCTATCGGGCAAGATAGCTCCTTCATGCTTTTCTCATGGTATTATCTAGTAGGTCTGCACACATAACACACATCAGTCCACCCCCATTGTGAATGTTGTCCTGTGTCATCTGTCAGCTTCCCAACAATACTTTGTGTCTTTTGTTCTCTCTGGGTCTCTTTCTTTCCAAAGGTTGTATATAGTGGTCATTTGGTGGCTCTAACTCCTTGATGTCTTGAGTTTCATTTTTCCTTTTCTCTCCTCGGTGGCATTTGCTGAATAACAACAATTTAGGAATGCTCAATGTGCTGTTGATTCTTTCAATCCACAGTATTGTTCTTGTAAAACTGTGACATTCCACAGAGCTACTGCCACAGTCCTTTGAGTGTCAGGCTCTGAATCTCTCAAAATGTGCCGTCTTCGGTTCCTCATGGCTGTTATCTGTCTTTATGATTTCATGATTAGACAATGTGGAATTACATAACAGGCATTGCACTAAAAGTGATGTGATTTATGCATTTATGCATGAGAACTAAATAGATTTTTAGATTCCTACTTAAACAAAAACTTTCCATGACAGTAGCATACTGATGAAACAACACACACACACATAAAACAACAGCAACAACAACAGAACAACAACAAAGCATGCTCAGTATTGAGACACTGTCAAGATTAAGTTATACCAGCAAAAGTGCAGTAGTGTCACTTTTTTCCTGTCAATATATAGAGACTTCTAAATCATAATCATCCTTTTTTTAAAAAAAAAGAATTTTAAAAAAGATGGATTTGACACACTCACCATTTAATCATTTCCAGCAAAATATATGTTTGGCTGAAATTATGTTAAATGGATGTAATATAGGGTTTGTTTGCTGCTTTTGATGGCTACGTTTTGGAGAAAGCAATCTTGCTGTGAAACAGTGTGGATGTAAATTTTATAAGGCTGACTCTTACTAACCACCATTTCCCCTGTGGTTTGTTATCAGTACAATTCTTTGTTGCTTAATCTAGAGCTATGCACACCAAATTGCTGAGATGTTTAGTAGCTGATAAAGAAACCTTTTAAAAAATAATATAAATGAATGAAATATAAACTGTGAGATAAATATCATTATAGCATGTAATATTAAATTCCTCCTGTCTCATCTGTCAGTTTGTGAAGTGATTGACATTTGTAGCTAGTTTAAAATTATTAAAAATTATAGACTC + 8B;ED<8D@BBDFBAGDFCGDADFBC=EB@@6?8<@?DGFEDACEAGE6DBC;BA?99A0=BAB;>@DD@@=FAFE&>=>D6DDE=;AC:@9F?BEACFEE;?AF8;3=?9;;6EFAA?;A>ADAEAC?>BC;@DB:C=B=EC??C5?<97;CF@BG@HHIF6FF?D=GED@DB8AD@FJGD/BI2>CIFCA=H8I;AHFIE=GGHFA8GEIHHH?I;HGHC=/EDIGG9H;IFF>@FCEJEJJEF8G:?EFIABDGA:IJD9DEDED3FHF:CJHJJHFH>I;BGG?CI9CHD?AFBEI5HF@>IID;AA:DBC=HICF@2BDCDHF:B9IE6F3IHHIDDDH=HHI)FHGGHGFIH.F@IFAF=EI@EFBI:@BGDCFEIGGJ?JEDDCGCAJE?;AEGEG=GIE3C=HFFIB'CBFHFFEGGJHJHIIEHHDHICHGIGGA?EJHGICGFECDI@IJEFEGG4JHIHC0=DE@96FCGA=JJAJGH>EFFFDAE:>CCECEGCIEGJIHCEIGIIGIGIFGDH?GIFC=B?E/?DJEB;@AEEI=GD:IG?GGCD@HBH<@E?C@I5C7GDJAH?DCFBEBD4FHFHIFFB=II>H:C;C?F'=GICHD0FBBEBIF;@4GAC?@AFG?;CDGHEBEC?HHIEHG5BHGI<@J6HHDGAF5FJICEE@B@JFGBFF@G@DD?H?D@D9GA:AE9?EBHDDFAEHDE@EC7EI:JHJJDCGGFE?=BE:FC6ICCF7@HB@H>CGJBFGF@?GD8DF@FBJJB;(B@BF5E4FICBEHGIKHIFKE>JHG>KK;?FJ:F@AIJGKEEKHJJBHKIJJADF5JAEIHF5H,F?<;GDIDEDEGG?CG=;D?FGBDDAGIIEBB4@JBCHCG@C5EBGCHFHH2HH>@D=;8>GJGIHCJ@IFG>?A@4HDE:FE3;ECD4B,HIGC2EAECA9FD;FAAEEG<=D:JFFEEDI:::@JCIF?JIIHIGGCICGGCF@:CC2EGEEECFHI9IDIDDFFHGDCHGG8HDB+EACCCB?FDIG?DI2HDHHH=%BDDIHEC>31F.:G?4HHGHGHCGFH<6EFIF?BHFBC?F=EH3GF;ICBE;HJ>BEDG?IGD?=AFFI=ID@JIIIBJF,=:;FBECIHFGJF9@=AD@6FBACG9HHD:BHCFCDEHIFBCHDH6GGEBI?CIEFC?F:D3FE?JGH?HGI>GCIDGDFIICCICFCDCHGCI8IGFGIGDBG@D@>*HEBFE?HA>A?:9AGD4FGBGCAC>GDC:HGGCAGDI5IKFKEJKI5KKKGKKKKK8KK=6GAKKI=JFKJGKCKKKHKII=CKIKKCKKKIKK?KKJDJ@>FKJKJKJKKKJAKKKJGKJ;KIKKKKKKKHKKKIKKIJIEJEKKK?KK:J@GIKJKHKKHK+KKKIE=KKGJI:KBK9JIJJGKKKKKKKJKKKKKKKKFKKHIKKKJKHKKKGKKEKKKKKKKBKJFKKKJEKKKKKKKKIKJKKKKJKKJKKKKKIKKKKGKJKJKKFKKKKKKK4KKKKKIK>KKKKKKKKKJKE8KKG;JHHEKKKKKKKDAJFKKKKKKAKKKGJIKIKJKFKKJIKKJJKKJ@KFKKKDKIKKKKK>KKIKKIJ(KKEKKKDKKIJKKKJKKJKJIKJK@KKKKKKJJJHKHKKJKKKKGKKAKDCHKFIKKKKHKKKHKKKKDKJ?KKKBKKKJKJ=KKK8KKKKCKIKK>KFKKJKKJJFEKKJIKJAKDKKKK?KKKHKKFKKKKKKJKKJKKKKFIJBKKKKEKB?:KKKKKKK;KKKKIKKKKJKJFK?KKHKKKKKGIKKHKJKKIK=KKJ;KKJKKGKJKIKJKDKKKKIKKK>EKKFKHK7KJKKKJKKICKJKK9KKKGIKKJKIKKIJKJKKKHKKFCKKKKKKK@K:KKKKKIKKKKJKIKBKKKHKK>KKKBKKHKJKKFKKKJKKJKKIKKJIJK?KF>KDJFJK?KKKKKKFKIA>KKHKKJKKHKJKHKKJKKKGKKKJKKH/JKKJJKKKKAJCKIKJ;KKK@KKKKJKHGGHJK>KKKKHJKJKKJK9KIIFKKKKGJK#GKIKJJF4KKJJKHBIKKJKHKHK7JJKJKKBKDKIJCHKGKBKKKKKCAKKKKJKJK8KKEKKKBDKKJKCJGJGHKKK @rCer/2000/1224_57_CCS CCACATTACTCAGTCAGATGATGAGAATGGAGCTGGAGGAACAGAACCGCCCCTGGAGCTGAGGATAGCCCTATCGCCGCGAGTTGAAGGGGAGGTGATACGAGAGGGCATGATTGCTGACTGGTGGCAGGAGCCGGATCCCAAGGGCGATGAGGCCGAGGCTGAGCCAGAGCCTGAACTGCAGAGAAGGACACCCACACCCCTCAAGCTTGGAAGCCTGGTCCCGATGGCCCCACCTCACACCTGGCAGCAGCAAGAACTATTTATTAAAAACTTAAGATGGGCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTGGGAGGCCAAGGCGGGTGGATCACTGAGGCCAGGAGTTCAAAACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATACATAAATTAGCCGGTGTGGGCGGCACCTGTAATCCCAGTACTTGGAGGTGAGGCAGAGAATCACTTGAACCTGGGAGGCAAAGGTTGCAGTGACTGAGATCGTGCCACTGCACTCCAGCTGGGCGACAAAGCGAGACTCCATCTTTAAAAAAAAAAGCAAATTTAAGATGGCCGGGCGTGGTGACTCATGCCTGTAATCCCAGCCTTTGGAGGCCGATCACTTGAGTAGGAGTTCAAGACCAGCCTGGCCAACTAGTGAAATGCCATCTCTACTAAAAATACAAAAATAAGCCAGGCATGGTGGCGCAACTGTAATCGTAGCTACCCGGGAGGCTGAGCCAGGAGAATCACCTGAACAGGAGGCAGAGCTTACAGTGAGCTGAGATTGTGCCACTGCACTTCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAACAAAAAAACAAACTTAAGATGGACATAGCTGACTGGGCCCTGTCTGCCCACCCGTGAGTGCTGCGACCCAGGCCATCCTGCCACTTCTGTGTCTCTGGACCACAGGATGGTGGTGGCATTGCAGGTTGGCAAGTGGGCTGACAGGATCCACCCTCCTCACTGCTCAGCCCTCACCTGGACAGTCTCCTGGACAAGAAGTTTCCAGCTGCTGGCTGGAGTCTCAGGCAAATTGCAAGAGGGTCCTCCAGGGTACTGAAGAGCAATGGACTAGGAGTCTAGTAGTTCCAGGGCCTACAGAGTGCTCAATAAATTTTGTTGT + '$%$#"#%""$"#%##$$%%$*)&%)$+,(,'(',(''%##''*-*+(&()*&+-,(&$(&)')+*%()'&&'$#&#%#$&#&''+-)*+*&$*%*'#$#"#%$$*+&,-,#%'"%&,-,),.-,,%$(*&(+,)-,)$$,&,%'(%,,--(,,,.**(,(,,+''+((+-+-*-,*$&*%%#%&)'$*$'%)-,$%+)022-443)-)5/4%(+/4/4310,2%50163440,(.$*,*#%+*,3$)0+2/.-0+)-'(/*54+..(0/54,+4-4.53*0-)'.3-3+.2246/+4101*2253-4-/20+0*.*-3%+0(564605-505--%230./1//'.)1)400500.3101/,$()//1'36/5-0/65.4,2-32,-24%10.-+,/.134/%-4-//+,'5..*3*-$,-&###14((),.1342310602$1/12+/%,($,2+0('%#/1645.+'202231*340(00)220&646152,561$3441365122-)$3+.14004./31(.242,/'+04*14102.+,1+34/44*,0..,0133#((36011&-)2.+4#+./1(*152551/052&2/4+40+1/*22,(.1%4213'13-5/652210623''#-3*022*25+0260--2)**')%.,#02404+-&*.4))411/05+2443/&+.3434/)33*0/'45*/)02)&+,1.,'*#1,460./10030-)'+#,0+*+*0435663565516.11/,*0-4-$(64*6/4.03635..23620333,(03/502245-52-,3335,./20+016+//.10213)14.1/04*-653420-1003222%.432414+)66.56261415655014/*/+50.32,)+-$,.,$02//(,02()0262'300541*64/04-1$.31,11624*1--,-/+0.1*.0*,/)3123*421.2.+*4)-/5(53(504+.,0-*+79:.9/,580/-6682226(18-612&374259465%+/57446-(3452453)5;2022,'5/,46$$%/1//-+31)0*-)...$'.+.(&/..2+111(.(-/&-/*%2/0#%%+*($,)'+(&)&")+),+')-)&%))'+)#))&*$#$(,'+&"#%##%$+++($$$$)-+$&-)**,)+ @rCer/2002/1435_58_CCS ATGGGGAATATAGTGGATTGAAAGATTAAGGTGATTAAGGTGCAGAGTGCAAAAGGGGAATGGTTCGAAATGAGGCTGGAGAAATGGTAGAAACCAGACCATGCTGCACCTTGAAGGCTACAATTAAGGACTTTTGCCCTTATCAGAAAGCAATGAGAAGTCATTTAAGGATTTCAAGCAGGAGTGCCATGATCAGATTTGCATTCTGGAAAGTACATATGTACAAGCATGATAAAGTGCATTAGAGTTGAAGAATATGAATATGAATCAACAAAGTAGAACAGCCAGGCGCGGTGGCAGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCGGGAGAATTGCTTGAACCAGGGAGTTGGAGGTTTCAGTGGGCTGAGATCGCGCCACTGTAGTCCAGCCTGGCGGCAGAGCAAGACTCCGTCTCAAAAAATAATAATAATAATAATAATCTTTCCTTTTTCTTTTTATTATTTTTGTATATTCTCTTTTGTCTTTTTCCACATTGTCTGAACTTTTAGGATCTTTTAATTCAGTTTGTTATTTTTGCCTAGCATATTACGAGGAAGTAATTGAGGTTTAAAAGATATTTTAAATTTTTTTCTTAAGATTATATTATAACGTTAATTTGAATGCATTTTTAAATCTAAATGACAATTTTTAAAACCTTTTCCCCATTAATAAGCAGTATACATTGCTTACATTTTTCTTTTAATTCTGTAAAGAAAGGTGATTTTTTAAAAACAAATTACTAAATATGTTTAGGGAACAATTTATATTGAAATTTAAACCAGGTATTATAGTATCAAAAATCAATAAAACCTGCATTATAATCTTATGTAATCGGAATTCTTATATTTTGACCATATAAAAATCAACTTTTTTGTTTTAAACTTTTATACTTTATTTTAAATTAATGTAATTATAGAAAGATCTTAGCCTACTACTTGCAAATACTTCACAAACATTGTAGTTGTGCAGAGTCTTACATCCCAATAAATTAAAAGCCAAAGTGAATATAATTAACTATATTTTCTCTTGAATGTTAATTTTTAAAGGAATAGACACATTTGATGTTCTAGGTAAGAATTTTGATCAGGCCAGGCGCAGTGGCTCACACCTGTAATCCTAGCACTTGGGAGGCCAAGCCAGTAGATCAGTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTGTCTACTAAAATTACAAAAAATTAGCTGGGTGTGGTGGCACAAACCTGTAATCCCAGCTACTTGGAGGCTGAGACAGGAGAATTGCTTGAACCTGGAAGATGGAGGTTGCAGTGAACCGAGACTGTGCCATTGCCCTCCAGCCTGGGCGACAGAGTGAGACCTCATC + =89=91=4=;44=9=;<>/>??9>;?;=4?::=;93;2?:<:;59>;>8<<<9,0<5(:7*75>;=9::7:8173::?99>?=>:=>897:><>;76;?989=5>=>=;47*=?4?988:>?>=:?>=:>><=>4=><6>;9<=85;;$7<=80;9==<>=88=<2?78'6;88;=3=:38*3=9==589=6==>>;<;196<<:=7==?90;96>=8>:<9:8?8>985;879=5:>9<4?99>>>?>>?;>;7985><9<=9;;59:>8>?=:67-79;:::79=1869?>:>>93090046+=:??9>?:$199:>737?7=:72906>98?6A7C@B<=/<<9=0=CA57BC@A:4>79:=;85<69<157A?=;=56<6BC=>ACB>@=1:;7898;;:?>A@B:3=@@2A=B@>@.;@CAC0'A5@@.??.$:;>AA*>A>B@7@B;?=AB>5>CA>A>BABBB=>=<=C@C@==B=?;>>B7@=(;A@4B>:AAB@;CC:@B>=?@)5<;<=<@<>2BCCBC=3=4::9=>:7><=96?<2>;7C=:5?=>8:ACC@5==7(58?A<;>>?6=<3:5>?>A>>2:.>7BA;;??;9@>6<56:77=?>@-7:9@+AA@:BAC:B=<6@<>??6.37=/@:.>6A?:66<<6=;<)@@,.>%95A?>B?:3?<>>5@=>8<@@?@<5:BB=/;C0;836':67@?B=??@?*A?42'?<>CBB:A7A@;>;>2:@BA@6=?C=:/>BACC?CC?CAC<>B;@ABBB7B@>:3>=A<8A4>=;9:=4;;<:=B6@?=59==;9:4;?:2*.7<>5*/77:.6>578;044;A>?0B@=C>B=B?97<9><@@3==@>B=A=6:7:=1<>??;@0=8:@0A9:6;;9:588;>?78:>=79=;>?==<>;;17>29>?:>;57=(?<<0/>9=9:3=>?>;9>4>:?=7>:5.;8?=??<:><<6<>:4>:>9=/=><;><=>>4;839>=:270075>??9:03=>:>>>3=7<=9963+3:<<3><9;>>;=+?9799>;8>?596;:=>?9;-6?<:>;20==3?67>?;<9<:>5>=:;;6<7:8<8;>3>?>?:9>>9>=>273=7)5=/887>:;?>>:570?>>==8874(<:6>=89>;-89)97999:? @rCer/2003/25_1676_CCS ATGGGACCAATGGAAACTTTTAATATCTTGAAGATGAATATCTGTGTCTGTAAATGTTAAGCCACTTTAATAAATCATTCAATCAAATTTACTTCAGATGAAATCAGTTCTTTTTTCAAAAATTTGGAGATTTGGAAACCTTAAAATTTTTATATTTGGCTGGTCTTCAAATAATAAAATAAAATCAGGAATAAAAAACAGCTGAACCAATTTAAAATTTAATAAAAAATGTCTTAAGTCATATCTGGGTTTCCTAACATGTATGCCAAGGCTCAGCTATTTATCAATGATATAGAGCTGACTGAAGATTTAAGTCTCCGAAAAGCAAAACTTGAATTGGAAACTTAGAGAAAATTTCAACTATTGTAACCCTTGTGTTGGTGTTAGCCATGAACCTAAAGACAAAAGGTGTTGTGTTTTGTTTGTTTTAAATATTTAGTCATTATACTTATTGGTTTACTCTAAAGGGGAGGGAAAAATTACATTGGATTTTAAAGTGTATTCGTATTAAAAGATAGGTAGGTCATTTTCTATTTCTATTTGATGATTTTTCAGATCCATCACCTACATTACTGTTGTGAAAAATCAGTGTTGTGGCTATAATATTTGAAATACCGAAAGGGATCAAGGGCTCAAAAGACATGCAAATTATCACTGAAAAGCATTTGCCAGGCAATCACTGGCTTCGAAACTCTTTGCAGTTAACTGTTCGTACCATTATTCATCCTTTTTCACATAGGAAATTACCAGCCAACGGAAATGGCCTGGAGACAACACAAATGCAACCTAAATTTTACTGGTCAAAGCATTAAAAGAAAAGCAAACAATCATTTTCTCGAATTGCTGATTCCAGAATTTTTTCTGTAGAAATTTTGAGTTGAGCTGACTGATGTAAATTTGGGTTTTCAGCCAATCCTCCTTCACTCTTGCCCTCCATTGAAGCCACGTAGATGTGGAAGGTGAACTCAGAGCAGTTTAGGGGCAGAGATTGCCACTACTCTGTGTGACTTTACATGTGTGAGTGGGCAGTCTTCCCTCAGTCTGCGAGGAGAGTACGATTTGTGCTATATATGCCCCTCAGGAATGCCAATTGGTGTTATCGGCTAGCTACTTATTCCTACCTGTTTTCCCTCCCAGCACTGATCTTATCCATATGACCCATAATTCTTCCCTCTCACACACAAGGTGATGGAGGTACAAATTATTATCTCTTAAGACAGCTTGTGGGAAAAGGAGAAATTTATTATTTAAACATAAACAGACACAGATAGAACCATCAGCAATTTGTGACTATAATGATATAGATAAAAGAGAGCTACCTCCAGCACCTAGCAAGTACCTGGCATCAGCTCCTTCTCAAAAATACATGTGGGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCAGAGGCGGGTGGATCACCTGAGGTCAGGAGCTGGAGACCAGCCTGGCCAACATGGTGAAACCTGACCCTACCAAAAATACAAAAATTTGCCAGGCGTGGTGGCGGGTATCTGTAATCCCAGCTACTTGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTGGGCAGTGAGCCGAGATCACGCCACTGCCCTGCAGCCTGGGCAACAGAGTAACACTCCGAC + FBDKKH7G@JEDJBGJJ6DIJ8IKGJKIKBDJ?IHBJHGE;IJKKJI@JG6JKKKFE*JJJ81JJ/D1JKIDFI9I,G>)8IKKJF?FAFKJKAKCK1KF0FCB6EE@JG&KJKKJDH2I?JIKIJIAGFJKGDJK/EA9GD0GIH;HB>BBEKHICJ?H@KKBJJ@HJJIB?HJJH6JHGC4BAFKEIIK=JFEBIK?K>IGBDJJ+KKKEJ.JHFCIKK:FEKKK2KKCFKJGII3FHJ>IKI>JIKK@KKK@K9KK5KH:HGKEHJCHKIJEKE?DEIJKE,JIJJG:IJF0=F3?DBEHJJKAKIKDKKEAHDF:JK?IJGJCJI'HJKKIKJKGDKEKD,7;FGKKEE;==FKDK<.-3,:FBEADCBJ8@>CCJJCKJIAJHI;:=GEDD0AFFF>IGD@I7D7C=EG>F=.:FF=IGI8IEHFBE@FFJBJGCED>K4HABHH6EFKIHFJIJI>CA0>FGHFICG);CKC@GBHF@0CFKIGIAIAD=IDBB>BDCHF4IIKC8KG@DCIGDICB;EAJFFF<:F8GIJJ;HEHFI1DIC7JH@B)GEE>1GJ=JAKIIFJJ?JBFFHCF*EIJIJIIFCIE8HH5CHKIGH5IHCIGFKJHCECIFF@KK?IK5HF'IIHHCGDK>JFGJJFIKHJ:HDJIKHDKGCDDHHKJHGGDGFFCGIGE9IHDIBK?CHG:JIJI@HIJJGH=IJD8IKKIFAGH7IKDC:JEJ:>AEAIJIKJKIAGJHEGHHJJ?IDJFHG?IKH=FEFFHA)IIE:I<=1DICKKGGJJ?JKCGIHE@-HHGJKFGHCIHIFIE9JDBBJICIKAI5GIEJFGEIFG=FHIKJFBIIEK8JIJKJDJKIJJFKGHKFHCIAK?EHJFIIAJCHIFKJ;JEBKK@FHGJHFF;FKKJGIHJJJIFJJKJJ@GGEI:HKJJKIDHIIIHKKJC5EGCJJIJIJJCKKGFEB=KGCHHDJJEHIFGKHIDCEE=JFJIIFIJKHIIJI?4BFIH?DJHAIJIFFKH7JIJJKHHKH8 @rCer/2004/0_941_CCS GTTGTTATGACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCATGCATAATGACAGTGATTCTTTCACAAGTGTCCTTCTGGCTCAACAGAGAGTCTGTACCAGCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACGCTAAGCATCAGTGCCAGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCAGTGTGCTATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACCAAGAGAGGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCTCTTATTAAGAAAAACAACACTTATGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCCAGGGGTGACCCAGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCCAAAGAGGTCAAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGACCGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCTACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAGATCTTTTACTCACATTCTGTTGTTCAGTCCTCTGCACTGGGAATTTATTTATGTTCTCAACGCAGTAATTCCCATCTGCTTTATTGCCTCTGTCTTAAAGAATTTGAAAGTTTCCTTATTTTCATAATTCATTTAAGAACAAGAGACCCCTGTCTGGCAGTCTGGAGCAAAGCAGACTATGCAGCTTGGAGACAGGATTCTGACAGAGCAAGTGAAAGAGCAAAGTCATGTCAGAAGGAGACAGAATGAGAGAGAAAAGAGGGGCAAGACGGTTCCAAGAT + S*0,260463/251125&335:860785:84936<945;9=<6;5/>;<9<:3?<:69:9=6;9=86==;5;9<==>:;;==39;5998<4::><<64<:=>;=9::<;9>9;6988-67:8.<:+<:97496<=8<6<>6?>6===>>;9;<=9=76:990>=7>46<<=<:=<=18==98,9859:>?:86>9/<:/<>9><9>><987>=8<5=;?;3:?88=>>=/::;81<7:+<;:>>3=7899=<;><>:5;/76,=:0<>>:<>:.>>>991:>=8:=;6>9=6;<>=>7>8==8>:?>7?;889:88>;===:7;???>;=;:?9?C?<@787D;FB(??@;/-561;7?/=>7*-3%?=5:<=;1=:>AABBB2CA><9=76;->0841:<><@:)=:54>;;=>=6>;>B<9>?:6;<;;=?==9C98?C=1:1=3;<3+8;8$/,.3;:2639;9:67==>4:5@:6;=9<9<96;;=$:=<7<;>6>=@=4@5236;/<4>8857;&87878<4377=?<65733474:21,41%737:999765=389=861>=;5.;=>:==>9;767,7/<<>>;8<3<>=97;6=9>:=>:71:;28::66=9::8955.(+/92=1>=9,>;:<>;<<:8/:8=989<):4=5=>::<>=><=;<548.50:881<=?8=<=8=7<=<1:4<==?9>;=33<>>;86:>>?=<2=>.<:*::43568;,8474:.7::?:=68;62=89<'658:<<8;;2597+502717;824>4=:,=9==956:<89=>9898??=894*:9811286598;<;:;8;63;=8::=;;>663):887<1:?;;=;94:6<4:76,:78: @rCer/2007/1271_55_CCS GACGCTTTCGATGGACACGCTGCTCGCGCTCTTAATCAAGGAACCCGGTTTGGGCCATGCTGGACATGCTGACGGACCGCTGCTCCACCATGTGCCTGTTGGTCAACCTGGCCCTGCTGTACCCTCGAGCCACGCTGTTCTTCCAACTCAGCATGAGTTTGGATGTGGCCAGTCACTGGCTGCACCTCCACAGTTCTGTGGTCCGAGCAGTGAGAGTCACAAGATGATCGACTTGTCCGGGAATCCAGTGCTTCGGATCTATTACACCTCGAGGCCTGCTCTGTTCACCTTGTGTGCTGGGAATGAGCTCTTCTACTGCCTCCTCTACCTGTTCCATTTCTCTGAGGGACCTTTAGTTGGCTCCGTGGACTGTTCCGGATGGGCCTCTGGGTCACTGCCCCCATTGCCTTGCTGAAGTCGCTCATCAGTGTCATCCACCTGATCACAGCTGCCACACAGCTCCCCCCGCTGCTAGGAGGTCCAGTCTCACGCCTTCCTCATGTGTTGTTCTACCTGCTGGATGGGGGTCAGCCTCTCTTTGGTGACGTCATGTTCTCTGGGATCCAAGAACCCAGCCTCAAATCAGGGAGGTTACGCGGGAGGCCCCATGCATACAGGCGGTGCTCCTGGGGTGCCAGCACCGGGCAGTGTCATGCCTGCTGGCTCAGCCCTGGGTCCGAGATGCTAGGACAGTTGAGTGAGGGAGATGGTGTGAGGGCCGCGTTTCCCGAAAGGCAGGGGAGTCAGACCTCCGCCCCCAGCTAGAGCAAGTCTGGGGCACCGTGCCTGGGAGGGAAGAAGCCATCCACAGCCTTCCCGTCGCCGGCTTCTCTGTCCTGCCTACCCTGGTCCTGCGGGACTTCACTATTTGACTTGCTTTCCTTTCAGATATTCTTGGCTCAGGGCCTGGGTTGAGGGAGCTTAGGGAAAGGACGTCCGTCTGGGTGCTTTTTCCTCCAGTTTGCTGGCTGGCTTCTCCGTCTATCCACAGTGACCTCACAGAGAGGCCCTCCTGCCTCCCACGCTCATGCAGTGTCCCCCACTTGTTTGATCTCACTGACCGTCTACATGTATTTATATTCTTGGTATTTTCTACCCTCACTGGAATGTAAACTCCATGAAGGCACAAACTTTTCTTGTTCCCTTCTGTATCCCTAGAATAAGACCAACCTGAACCTGGCATATAGTAGCTGCTTAATAAATATTCGTCTGTCAG + 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@rCer/2012/0_1379_CCS TTGAGCCTTTAAGGAATTTTTTTAAAAAACAAAATTTTGTTACCAAGTATAGAATGTATCACCAGTCTATAATATGACAATAGAATGCAAATATAATTTTTAGATATTTCAACTCAGGACCGCCTAAGAAAATTCATATGTTCCTCACACTTTGGGGCCAAGTTATAGATGGGTGAACAACATCGTGCCTGGAAATCTGCTCGCATAGAAGAGCAGTGAGACCTCTAAGATTTTCCTGTCTTCACATTTGTAGACTAGCCCTGGGTGGATTTCACAATAATAAGGTGCAGGAATCCTTGCCACTTCCTCTACTTGTCTCTTGTCTGTTGTCATGCTAAGCAGCTAAAATTTGTGTAGCTTTAACATCACCATCATTATTATTGACTTGGTACTTAGGGCTCAAATTTTTTTCTTCTTGGTTGCCTCGGTGTACAGCCAGGCACAGCACAAAACTGGAGTATGGGCAGGTCGTTTTGGGTCCCTTGTGGAGCTGTTTTGGGAGCCTCTGTGATAGGAGAATACCTTGGAAGCTCCCACAGAGCAGCAGGGAATGAGGTGTGGGCTCCACCCGCCTCTGGTAGGCTCTCCTCCCGGTGTTTTCTGTTCTGCTGTCGACTGGGCCTGGCCCCTGATGGCACACATTGAAACGCAAATGACAGCAGTAATTGGCTGAGAGATAAACCACGATGAGTGAGTGAGCAGTGCGGCGGGGAGTTAAGTGGCTAAGTGACAATTACTGCTCTGCAGCCTCCGGGATCAGGAGTGCCGTTTGTTCTCGGTTTTAAAGGAGCAATAGCACATTAATTGGAGGAGGGCTTCTCGGTTAACATGCCTCACCCGGCTTCTCATCTGATGCTGCTTTGAGGAGGAGGAGTAGGTGGCCTGGTCATCAGGCCTGGCAGAGCTCATTGGCAGAGAAGAGTTTTATTTTAGACCCAGAGACTGGGCTGTGCAGATCCAGCTAGAACAGGTCTCTTCCGGCTCAGCCTCAGCTGCTGGCCCTCCTCCTGTGGTTACTGGGGCTCCAGAAGATGGAATGTCAGGGGGATCATGGTGCTTACTGCACAGTGAGCAGGACAACCTGATGGCTAGACCAAATGCACTCCAAAGGAAGTCTCAGGCTAGGGTAATACAGCCAAGGTGCTGCCTTAACAATCGGGAGGTTTCAGCCTTCTGAGAGAAAAGCCCTGATGCAGTGCATGATGGTATAGATTTGATCCAGGAAGGAAGAGTAAACAAACTATTTAAAAACATGAGTCTTGGCTGGGTGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCGAACACGGTGAAACCTCGTCTCTACT + S+4084:-832@4D4?,?FE@ED#<@>705(ED;$8HIEHKC8@>EE>=><>95.@==>D<=@F;B:3@C@<5==6D;>6+A5BF0C?;=;=@3BDFCBC<>63;BA1=8A:=9C6:C>>?63A>.B>?,CCD3=B<:ADCC?93+B/BC4FDD:F=>=5E@=DB>6>EGE==4BDE7?>>EEB;1EE>=GDBBE>7??.D@8CD:C@DF?H=BEH>F;9D7AADHF+>9GHB>BI@?HGB/B.HD%9BDDD@;A=@-F;G9HG0CD>AF>C6B?HH4HEBFH>7CI?CIIDA8-GHD9DHHIG>H+EIF4D?*6AHFIFEAD@G=F5A8?BI=E;CBDHECADDEC@G;FE:FHHE@IEDIJIIJAG=?:BB4G=??53ACAIIBF>60FEF8?E8?HFFAIHDCCC>?=@HFGD?F*EID?E>?2FB@:7922AE5DE6@A;HGC>DGCCC1HF=H;G5EAHGHEBHF4,FDBHDIHF@?>E4A.A?C@GDCFABE>I>.JICCH;I9ECHEIGF-FAC7FGD9A>HFG2FC:GC@BCJGEHG;=A8>=F:IDJFEJG2HIC3FB7FHIBA<=/>:@>>A=CG>I>;IF><>FDC@25EG=C+FFF4(CC43?8@FI=BBB;ID1IGGD<>9A9>AHBHEDICGG3BBF7H5<7D8B9>=EC7ABE9EDHCBB?GE8=G:JJA?F?AIEEG-=5??DG4CABBI8H589BHI5FGCA<>6ACAE?BF;F=FG7;7DIFFFB=EC?E@?DIBGEH>ADJGGF@HH>C>7BBBH;HH;EAF9<4GFDCIF?EBDF<5>;=>DHBJHJIIDGHCI3JDJEF=?HDA4EHB5B?GI@FGEICHAGGEGFB+DEAB6FG@DEAEC?AE:HFFF8AGE57IIHDG1H<$CEHEGGCAHF>ACICIHI=HFG8B9D@DFFFE9H=EF=<;H7DC<9FDBDKKHKKKKKKKJKKKKJKJJKHJKKKKKKKKKKHKKKKJKKKKBJJKKKIKKFKKJKKGKKKKKKKKKK?JKGIJKKJKFKKKJKHKKGKKKJGKKKJKKKKKKKKKKJKKKKGKKJK?KKKJKKBKKJJKHKKKKKKKKFJFIKKJKKKJIKKKEKKKKIKEKKK4KKKJKKGJKJKKJKKIJIKCKKKKJKKKKKKKGKKK@KKKKKGKKKKKKKKKKKKKKKKIFKHKKDKKKKCHKIJKKJIKKKKKKKJKK7JKKKKKGIKGKHJKJKKKHJK>KIKKKJKDKKKKKIK>KKKJCKKHJIHFKKKKKDKJKHKKIJKK>KKKH@KKKKKJKEKKHKJKKJDKKKKKJKKGKKKKJHKKKKJKJKKJKKBDKKK5KKKKJJKKCEJJGEKKJKKKKJJKKKIKJJKKIKKKKJJKKKKKFKJKGK?KKKJKKKJKKKKKKJKGKKIKDIKI@KIKKJJKIKKIKKKKKKK=JKKJK@KKGIJIKIJHKKJHKKHFKKEK8KKKJGKKKIKJKKKKKFKKKIJ=IAKI>JHKKKKKKKJKKKKKKJKKKJKKHIKKKKKJEKJKKIKIKJKJKJK;KJJKKKKKIKKIKJFJFKJHKKKIKKKKKKC2KJK>H@KKKK.KKKGKKKKKKKCKJKHHKKHKJHKKKKK8KKIHKK8IKKKKFKCKK@GIJKJ@KFKK*KKKKKHKKKIKJKJ;KIKKJJKKGKKGICKKHDJKKGKKKJHKK=KKIKIKGKKHKKHGKIIHJKDKJ?IHKKKKKIKIKJK5KJJJKIHCK=KHEJI'C:>;$KIJKKKJKKKFKKHKJ,KKKKF@KJFJJKIKKKAKKIKIKCKJHKKHJKCKJKKAJIIKEHKIKEKKKKK0KKKKJFKKJKJKKIKKJEKKKKKKKKKGBFKKFK:KKKK=KKJ<=JIKKHJKKKHJKJFKKFKKFJKJJKJKKJKGKKJKJKCHJKI>@HKEKAKJKKBKCHB;BH?KKKKJ?KKKJKJCKKKKJKIKJJKKIKHKJKKKKKKKKKHKIKK9J8IEJEKKKKJIKKKJKJKIKIKKHKJIJKKJKJKJCBKKKHJK6HKKGHCIKKG@JKKKKKKHJKJKHHK=KJJ+FGKGHEHBKKKKAK2KKJJKIK @rCer/2014/25_1774_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGGCGGGCGACGATTGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACCGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGAACGACATGAGAAGATCTGGCAACCAACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCGTGCTGCTGACCGGAGCCCCCTGAACCCAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATTAGTTACGTGGCCATCCGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGACCATCTACGAGGGGTATGCCCTCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCCGGCTTACAGCTTCACACCCGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGGCAGGCAGATGGCCACGGCGGCTTCCAGCTCCTCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCCTTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGTGGCACACCATGTACCCTGGCATTGCTGACAGGATGCAGAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCACCTTCCAGCAGATGTGGATCAGCAAGCAGGGTATGACGAGTCTGGCCCTTCCATCGCCACCGCAAATGTTCTAGCGGACTGTGACTTTGTTGCGTTACACCCTTCTTGACAAACCTAAACTGCCAGAAAACAAGATGAATGGCATGGCTTATTTGTTTTTTTTGTTTTGTTTGGTTTTTTTTTTGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGAAGCAGTCGGTGGAGCGGCATCCCCCAAAGTTCTACAATTGTCGAGGACTTTGATTGACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCTCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGATGCCCAGTCCTCTCCCGAGTCACACAGGGGAGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTAATCTCGCCTAAATACTTTTTTTTTTGTTTTATTTGAATAATGAGCCTTCATGCCCCTCTTTTTTGTCCCCCAACTGAGATGTCTGAAGGCTTTTGGTTCCCTGGGAGTGGTAGAGGCAGCAGGGTTACCTGTACATGACTAGACCAGTTGATAAAGTGCACACC + .$*..2,,,&/1*/,*'-..-0-0/&.*,.++--/11.1/&-111(%&0/&%++0&*0,/21*1..+110,.+.0,,-/-20--,-0*-(./1*.0(+/--%'$%-++-0/,*)'*,/-/11'-)%+&)/)-.&("%&+--.*,(*),.$0+%+,*,,,.*11-((%$(,,-).1-,0)'+./222,,1-+011&-/.-/'-.11-1-*-21.2.-.*#*%&)*++1/'&'++*-/-,,-0002,+.*$(+,0/.0($'(*+0+0,11--,),-.0**0/%*1.1.,$(##.*$(&-&/.0//1*)+,,+$-,.).-,1/+0(-0/),+$,0)-&'(%&&'&')(,0$,-$*$$#"*00-+*,*(/011*.,,,+'&.)+*+.01.-'+*'00%0/*()/-0*)11(+#(+$%0././1,+%1/%(0)0*-,-%/+,012-**,0)0/+,&&/+/0'/0/0//$.),-(/.*%++-.,02+##%%####'(%*%,&&/1#%(.-(+.-+/*-.,.),-/)1&1,*.+1-**&-00*$-*-*+-),/*020$('(%+)*,,$-$(+),+/0).$+,,,*$+..10()+1.$+*)&*%+$0-+%/.*"&$&,*),*&,0/#%#%)$(*-+-',-102'100'000-.-0--+-#*--%)&&,)&**,(**'(*,)&*$%%+-%./*+,0/,(*',+$'*,',*+,)$*',.0,+''(&(%&,)%$(%+*+,'*--.//++),.-00.*(,+##)(&*'-+#)('&$&'(+*1/00*%).,(+-,%-/0$+)/(%+*),01.-+$-*0-)&(**)+)011.,)-*0%.1')'.,)&..)/.1)&,0+$"*+,*1-21,-,*11,+-,.*+*##.-+3&2/5(4//05&+.(-.-33'/)(/+'-24.6*'4-4.1+*53(0.+1)/2052,0201/(.3'2/.(**.,.2/530(0+33/)3.1./6&)0.4)-5,.((-/100331*-$#''-,+$)'/.--'.).+,-2&-*.,%,,/-0%/+/---/%)..,--0+&0/*.*..0,/%.0.0($-/*11-/)%')%-'/1,+/0/+)0+&+-+$0111-0.--0.1.1.1/*/%),(/,.2/$$-'1'+**0%./00,,-.%+-.02'0,-%-,)//+*.'+,#$'%*-/+$(#%&#'(*,&+'&'+.,.-(,$),,(&#(*,-&(%***##)-+)$'(*'(+)&%),%+#"#%()+-.,)'(*%$*&'&&#&#'''+"$&&*$*)$)((,+))),()'#$##&+,&*)-&$&&%#))*---,---(&*,,($)+*,$,++*+),,&#)(,'*,,,'&'$%&)#(&**+)(-()*)-&'+.+*+)(&)--)&)%&$#$+++*#,)*(,--,&,,,&,+,))&)%'($#&''(',&+,*$$)*&((+--),,%+(&+++&&,++,&(*+.(+&(+',+)'')+),(%(-,+%'$#'&**&$'$"&()'*''---,$)++,.-+)$&$'(&&)&&+,''$&$&'*+)('-,,$)-,()((#)')-,+--,+%(+%&)-,%(-+,%+*&+'%*),,('+%&(,.**+$,*(#&%(&').,*#*(,,&#$*)*)#)(&$#"'*+(&%)**'()(&,--.-((+'*'*((*)),)-+)$),,,,-,(-,++))%#)*()(*('(,&)).-,-.-('$(*+--,-''''&**,&%%*)%%$%&(%"'*')+)++-*#)&&#!#%(''$(+'$&&,-(+'+))*)% @rCer/2015/25_1659_CCS ATGGGTACGGCAGCTCAATCCTGTCCATCCTGCTGCAGGAGGTCAGCCCTGAGCTGGTGTGCAGCATGCTGCGCCTCTGCTCTGGCACGCGGCTGCCTGCGCTGACCGTTCATGTGACTCAGCCGAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGTTATTTGGATCGTAACCTGGAGAAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCCGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCGTTCGTGTGCTTGAAAATTGGAGCCTGCCCGTCAGCCCATAAGCCCTTGCTGGGAACTGAGAAGTGTGTATGGGGCCCAAGCTAACTGGTGCCAGAACACAGAGACGGCAGCCCAGTGCAATGCTGTCGAGCATTGCAAACGCCACGTGTGGAACTAGGAGGAGGAATATTCCAGCTTGGAGAAACCGCAGCATTAGTTTTTTTTCTACTTGTGTGTCTGGGAGAATGAACGCACAGATCTATTTGACTTTGTTATAAAAATAGGGCTCCCTCACCTCCCCCATTTCTGTGTCCTTTGTTGTAGCATTGCTGTCTGCAAGGGAGCCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGGCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTTTAGCCCGCCCTCGCATGGCACCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGCTTCTTGACTGGAGGCCATCAACCCTCTTGGCTGGGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGGCTTCTGAGGTGGCCTCCTGCCCTGGTCAGGGACCCTCTCCCCTTTCCTGGGCCTCTCAGCTGTACAAAGCAGCAAAACAAAGGCAGTTTTATATGAAAGATTAGAAGCCCGGAATAATCAGGCTTTTTAAATGATTTAATTCCCGCTGTAATAGCACAGGGATTTTGGAAGCAGCTGCTGGTGGCTTGGGACCCCACTGGGGCCACGGTTTCTCTGTCCCTGGTTCAACTGTGATTTGGCTTTCCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGGTTCTGTGGGTTTGGGTGGGAAGGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCAAAGGCCCCGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACGTGTCCCTGGCTGCTGAGGTGCTGCTGCAGCCTGCACCCCTCCCCCGTCTCATAGAGGCTCCTTTTGACCTTTCTTTTCAAATAAATGTGGATGGCGAGTTCCTAGGCCTGTGGCTCCTGTTAGAGGGCGGCATGCTGAGGGGTCTGCTGGGTGTGGGTTGGACGCTGGGGTGTGGGTTGGATGCTGTCTGCAGCCCACTTGGGCACCCATGCTTCTGTCTACTTCTGGTTGCCAGGAGACAGCAAGCAAAAGCCAGCAGGATACGCAGTTGCTATTAAATGGGACTTTGTGAGTTTTGTTTTGCACTAAAGTTTCTGTGATTTAACAATAAAATTCTGTTAG + 44220.2346421100,3/,3.,/265+06225.5+2063364654366*2/461310,,(02462//.102/5465,/,0-/.43,,03.2041.536/0652.466562630-%32-/2,.51,3/664062363,1011/3'315513316552534-5+&56,2/-521626566,3..,+.05*555252635/11034644511//465/1/233.155541)..1645.$0.15656.4(5345.03*-0-222/230,11325465120565./40535564013*,.44/2646463)25*2&3./20.50-42512.53'2616452210./3.1564/466,00654555/-4646443%321/-525663666201556035+//641255134*6550331546)$)*2/6*,3642+553265/40656/0426641-5/*504663063/6414345)41,00-143,14461.433344.64161612244244.+001+/*00143&-)3,1525%32311/.24/1146462524611,/2*/32)135-4454/-245315456.620/4/5+1246441465406454/365-44445&36401133.6/0530.1,'265153245)/045%-)43.3'11202.&1245/61550340443453.30262/6)23.133445.1164'32*4//2*2154),/5645/534620&034311.66542;2474-36:72-1/734353.4205*0.1,)/78647879:4445/*113+388;:6;9:::8;528.79:85801752-7-52328843956621354/5475-2642.899957/76:9:22;94640;56;9-27/9581:8564641723(71(,4344155+,47537)-77488-86,:7173/57681251/5+8074407&57666;757234/4594555895642.6347960798;::905,5+163(6578*87751&172:098;9465956389395521474-:::9;565365166578;:3:2-5&4374654006.2051944060610/1463566516265.5251466155354.64'3445+/4045265,2+34.1'0-2/+31+645/0044//44.66045102/'2'35526465+'(-30$2,15.3)21551461/*211/5615/66665-46464163/666661413005016/9698'77.:-9557567/40699::::58395-4596:59:967/1997:::9,1941,-443103.36397673:88.98876:7::95484/77508*1583155)3,,&1343)54435222/553$,45/02&1,4-1.5/3+5.45345656355253564)55365/421)033540140566622034462651365(1-5454/3426560315/)0056621366301511365251/50426441464*1425144140)155663651465622+,55556304116311/55,//52655-41644)2/--13555504%133.),455254*&112'223/4125266250).--0452664305-4 @rCer/2016/1323_55_CCS CCTCGCGCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACGTAACTGAGTGGCCGCGGCCCAGACACGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACATGCCCACGCCTTGGAACCCTCCTTTGGTAAAGGGAAGCTGTGGTCCACACTCCCTTCAGCATCACCTCTAACCCCGGCAACTTTCAGCCCCTAGCTGGCATCGTTGCTCACCACCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCAACCGGTGGGACAAGAGCAAAGCCTACTTGTAGTCAAGAAGGCCAAAGGGCCTTCCATCCTAGCCCCCCGCAGCATGCCCTTCCTTCCCCGTGGCAGGAAAGCCAGCAGCCCAGACTGCCCCAAAACTTGCCCACACCAGACCAAGGGGAGTGCCCCAGCGGCCCGTGTCTGGAGGAACTGGCCCAGCTATTGTGTAAGAAGACCAAACCCCACATCCTCCTTTCCCCTCTCTCTAGAATCATCTCGTACCACCAGTTCCACTTGAATTGAGATCTGTGCTCAAATCTCCTCCCACCTCCCTCCCTGCTTTTGCCTTGCCTCTGTTCCTCTTTGGTCCCAAGAAGGCAGCAGCCGCAGCTCTCTCGTGATTCCTCCCTAGCATCAGTTTCCCGAACAGTCCACAGGTCCCACGCCGCACTTTGCGTCTCGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCCTGCCCCAGGCCAAGAACTGCCTTCTTCATTCCACCCACACTCCCAGCCTTTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTCCATCTCTAATAGACTAAACCTAAATGCCTCTAGGACAGGCTGTTGCTATCCAAGGGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCCTGCCACATGAGTTCCACAGGATGGTCAAAACTGTCAGAGCATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTTGGGTTAGTGTTTTTTTTTCTTTTTTTTTTTTTTTTGGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAGAGATACATAAATGTTGTGAATTTCCAGGTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACATGCTGTGGAAATAAAATGGATTGTG 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rCer/2018/24_1652_CCS ATGGGGGCAGTTGGCAAGATGGCGCCGGTGGGGGTGGAGAAGAAGCTGCTGCTGGGTCCCAACGGGCCCGCGGTGGCGGCCGCCGGCGACCTGACCAGTGAGGAGGAGGAAGGCCAGAGCCTATGGTCCTCCATTCTGAGCGAAGTGTCCACCCGTGCCAGGTCGAAGCTGCCGTCCGGCAAGAACATCCTGGTCTTCGGTGAAGATGGTTCTGGTAAAACAACCCTCATGACTAAACTACAAGGAGCTGAGCATGGCAAAAAAGGAAGAGGCCTAGAATATCTCTACCTCAGCGGTCCATGATGAGGACCGAGATGATCACACGCGCTGCAATGTGTGGATTCTGGATGGAGACTTGTACCACAAAGGCCTGCTGAAATTTGCAGTTTCTGCTGAATCCTTGCCAGAGACCCTCGTCATTTTTGTTGCAGACATGTCTAGACCTTGGACTGTGATGGAATCTCTGCAGAAATGGGCTAGTGTTTTACGTGAGCACATTGATAAAATGAAAATTCCACCAGAAAAAATGAGGGAGCTGGAACGGAAGTTTGTGAAAGATTTTTCAAGACTATATGGAACCTGAAGAAGGTTGTCAAGGTTCACCACAGAGGAGAGGACCTCTGACCTCAGGCTCCGATGAAGAAAATGTTGCCCTGCCTCTGGGTGACAATGTGCTGACTCATAACCTGGGGATCCCGGTGTTTGGTGGTATGCACAAAGTGTGATGCGGTGGAGTGTCTTGGAAAAAGGAGCACGATTACAGGGATGAGCATTTGGACTTTATCCAGTCACACCTGCGGAGGTTCTGCCTTCAGTATGGAGCTGCCTTGATTTACACATCAGTGAAAGAAGAGAAAAACTCGACTTGTTGTATAAGTATATTGTTCATAAAACATACGGTTTCCACTTCACCACACCTGCCTTAGTTGTGGAAAAAGGATGCGTTTTTTATACCTGCAGGCTGGGACAATGAAAAGAAAATAGCTATTTTACATGAAAATTTTACAACCGTGAAGCCAGAAGATGCATATGAAGACTTTATTGTGAAACCTCCCGTGAGAAAGCTGGTCCACGACAAAGAGTTGGCAGCAGAAGATGAGCAGGTGTTCCTAATGAAGCAACAGTCACTCCTTGCCAAGCAGCCAGCCACGCCCACGAGAGCTTCTGAATCTCCTGCAAGAGGGACCCTCTGGGCTCTCCAAGGACTCAGGGTCGGGGGGGAGGGCCAGCCAGGTGTGCCTAGCTCCTCCCCAGGCACGTCAGTAAAAAAGCCGGACCCAAACATCAAAAATAATGCTGCAAGTGAAGGGGTGTTGGCCAGCTTCTTCAACAGTCTGTTAAGTAAAAAGACAGGCTCTCCTGGAAGTCCTGGTGCTGGTGGGGTGCAGAGCACAGCCAAGAAGTCAGGACAAAAGACTGTGTTGTCAAATGTTCAGGAAGAAACTGGATAGAATGACTCGAAAGCCAGACTCTATGGTAACAAACTCTTCAACAGAAAATGAAGCCTGAACCTCCTTAAAAAGTGCATATGTCAAATGACCAAATAACTATGTATATTGATCTGCTAAGACCAGGATTTTTTCTGATATGGCACATGCTATCAGTTTTTTGGGGCAGGGGAGATGAAC 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23'3.4351332450+0+*,.23)*+&22+53/524602*03.2.'//20532**11%01.21,/0,2,+-+0+/21'1.03)40,,13+114.*.0+%..-0(..045,40443*0/,+,$.'+-'&5)()/-/%1*--0+%*)'-.-40+2432306-266451525*,160.&2'.,(21,31/*.651546662+233133624/(.35662(541103-0541*0/,31.6341.41131'245110/45+31$,)*'',0-,.-/2-1..24650('31/'$)%///*')306555*41407636569338636962575851/246302+,-:2(425(042321334.)4612987$40'-+,*-)3/145&06/2-0,77685'*..40185;7183:412469829-.0/1054-(/.3400+31345301203.1-34500443/.2/431--2,453566215331413/(1.2,-/0015/1-,-02+)'(2012+/03%&+4/-++.*+*+.1..+26401112565212-2/+632-1//244$0/-+--0110/3623,0-1,..%.1202%/+4441)/22-202,,00-10/*1-)'0303+,0-42,,12.520,15315260/613--/5.%0/3(*1+.'$#,,04.02/3/(&++3..15-)/),(#..-.2(4--1./%.0-1),01/1/*,/)/**--+340,/.*.'/,2++-043.1#,(+*/22(/114,.2552).311*,(22163.3/,+..3(2++/1'*-)')-2..302-*.0)(-(.,-../1%+0-,*,2.0.4+2-64511./3/1440+130/4/-1'(,.'$-)-1'++*))2.,-/'//)/-(0/+.135/..35402-/,*3/055-)304).-&,..0./.%/)2(40.*+$*/.'+4//(#)&0/..(/0*+64+3**1*.*./0/+(/*%..-)*2/-/0+,3.--41,'*,/+-..%-''*.0+.+-*).13/654302/-*,/+03+(/,*,$+.-%(,*(((1160/63(*().&-361*02.2:323/979557&223856(446894.2-1/60'224+4668.%1.62234-+2/-4,-(/1/),0141-).(-0/212335+-4--(/10)41-03'(,122+/&*//+-1%,),-.01()%''01.,.3110241200-3241#.,,+*,0&--2(2/+32&)&--)31438/3$2)*514+%10.1+-(+20$,0/354376<6/8108<.535.;87933;4+)515/28<=:5,<2:697=;=9=<672:93=:%:78:=25=:=789.&89733-4<6<46=6<6<%46<<<<;(5169;9-63&11&1,3,4438>842715=996:,988:36(7678.4134-/1++-*15-4)+/-/.083&-12(*'-,+1077;64741,77803/7882603.4524:>7:8:56&>;8;?;A.:865;4;:1=:4*54+66<4?*86:@;.16.;259;?.<52;992'=;:4?9:97<9:053?<+7/<<<>74;:=?;7;8)52670053-7:87;1&1'0783>>578)564:4%1.588,:;7:347*38= @rCer/2019/25_1989_CCS ATGGGGGAGACGGTGCAAACGGCGTCGCCGCCATCTTGCTTGTGCCCCCGCTTCTCGCGCGCTCCGTTCTCCGTGACGCACGCTTCCCCCTCCCCTCCGCCGTGCCTGGGCCTCTGCATTGCCCGACTCCGAAGGAGCGCGGGGGCGGCTCCTACTCTTCCTGGACTCCTGAGCAGAGGCGTTTGTCACGATGTCCACAGAAGGAGGATTTGGTGGTACTAGCAGCAGTGATGCCCAGCAAAGCCTACAGTCATTCTGGCCTCGGGTCATGGAAGAAATCCGGAATTTAACAGTGAAAGACTTCCGAGTGCAGGAACTCCCATTGGCTCGTATTAAGAAGATTATGAAACTGGATGAAGATGTGAAGATGATCAGTGCAGAAGCGCCTGTACTCTTTGCCAAGGCAGCCCAGATTTTTATCACAGAGTTGACTCTTCGAGCCTGGATTCACACAGAAGATAACAAGCGCCGGACTCTACAGAGAAATGATATCGCCATGGCAATTACAAAATTTGATCAGTTTGATTTTCTCATCGATATTGTTCCAAGAGATGAACTGAAACCTCCAAAGCGTCAGGAGGAGGTGCGCCAGTCTGTAACTCCTGCCGAGCCAGTCCAGTACTATTTCACGCTGGCTCAGCAGCCCACCGCTGTCCAAGTCCAGGGCCAGCAGCAAGGCCAGCAGACCACCAGCTCCACGACCACCATCCAGCCTGGGCAGATCATCATCGCACAGCCTCAGCAGGGCCAGACCACACCTGTGACAATGCAGGTTGGAGAAGGTCAGCAGGTGCAGATTGTCCAGGCCCAGCCACAGGGTCAAGCCCAGCAGGCCCAGAGTAGCACTGGACAGACCATGCAGGTGATGCAGCAGATCATCACTAACACGGGAGAGATCCAGCAGATCCCGGTGCAGCTGAACGCCGGCCAGCTGCAGTATATCCGCTTAGCCCAGCCTGTATCAGGCACTCAAGTTGTGCAGGGACAGATCCAGACACTTGCCACCAATGCTCAACAGATTACCCAGACAGAGGTCCAGCAAGGACAGCAGCAGTTCAGCCAGTTCACAGATGGACAGCAGCTCTACCAGATCCAGCAAGTCACCATGCCTGCGGGCCAGGACCTCGCCCAGCCCATGTTCATCCAGTCAGCCAACCAGCCCTCCGACGGGCAGGCCCCCCAGGTGACCGGCGACTGAGGGCCTGAGCTGGCAAGGCCAAGGACACCCAACACAATTTTTGCCATACAGCCCCAGGCGATGGGCACAGCCTTCCTCCCCAGAGGACCCGGCCGACCTCAGCGCCTCCTGCAGGCTAGGACACTGGTGCACTACGCCCCATGCCTGGGGGCCAAGATTCTCCAGCAGAAAGATGCAATATTTTTTTGTTTCCTTTTTTTTCCATTTTTTTCTCCAAGGAATCAATATTTCAATATGTTGAGCTATGTGTCCAATGCTATGAAATTAAAATATTAAATAACATATTTATGGCATTTTCTTGAAGAGTGTGGTTAAAGAAATATTTCTTCTTTTGTTTTTTTTTGTTGTTGTTTGTTACCGCCACTTCTTTTTAGGAGCAAATCTCCCCAGGGGTGTATGGTATTTCTTGACTCTTGGAACAGCTGCTACCCCCAAGACTTGCCACGTTGTTCTGCCCTCAGATGGAATTAGGTGAATGTGTGTAGCTGCTTTTTCACTCGTGGTCCTCTCCCCATCCCTTGCTCTTACGCCAGAGCTCTGTGTATTTGCATCCAGAGGCCATGGAAACATTCCTTGCATTTAAGAGATTTATTCCCCATGGAGAGTGGGTGGGTTCATTGCCACACTCTTTTCTCCCAGGGACCCAGGAGACTAGGACTTTGTGCGTTTGCTGCCACCTCCCCTTTATTTTTTAAATGCATTAAACACTGTGCTAGTCTCCTTTGCATGGACTTCAGACTGCATGAAATGCAATAAATCTCATTTT + FI:JGAJH@JIHJ>EECKJH@HFIIIJHKHFEDJGHIHIIK=KKG?H=JIGIG8=HIKGJAKFID>HJCKJFJJAFIHJFJJBGGHEH?FHDI;KKIKJDKKF8G@DGKKJKKCFKF>J1GFDCKKKKIKFKFII1CJIIKIKDKGKK@JGJIFD4KKJJJGJ7JKKKFKKGKKFJJJDGKK>KJKJCEKKKIKKKJDKKKKKJJKEJKKKJKHDFHKIJFJHKBKK?2IJKIGKGEBGCFJEHKJKJKKGIAIJKKBJKCK=KKJJAKKKK;2JKKJIIJFIIKKG9GJJKHIKKIIJJIKIJKIEKIIKJJIJKKJGH=KJHKIEJBC;GFJG?IEGEGDIFJJJKIJIJHJFJKK@KJ;D9ID>+JJH:IIEBIKJA8KKCKGKKJKJIFJIKKBKJKG?IHKAIFJFJJKIJHGCGIJ0FDC?GKKJIFGKKKHKJKJJJJFEG6J5JIAHKGDGFKFJJJ?JAKJHKJHFFKEF@EIIGDHKKKIJKJIJDJKJKJIKJGIKGI2IKJEKGDKKFGJEJKJGJ1KIKKKIKJKC@JKHB@HIGJKJJKKJHEGIHKBJEBF=JJJI:IIHEJJJFKKJJKKIKDKKIKEKBAJIDKKJKJKKAFIJFJFKCJJHJJJJJKKJJJCJJHKJIKI8KIIKDKIJIJKKJKKKKJJJJJ@IJBKF6HGFIJH(HGHGHBKFIFJJ?H8CGHDEJGHFI=5BFKIGKHKJKJHFKGKKIKJKKJKIKK;KKJKIJ=GKJIJJKIKKGKKDJI=JIGKDAKHKK=FKIJKKKKJHJKIKJKIJKKKG;JJJJIJHDKIKKI?FKIIKJKDKKIK@KJHHKKKKKJHJKKFJKKKJJJJKHE9JIKKJGKKKKHKKK@ICKJKKKKKKKJKKKKIEKGIKIKK>KKKKJKKGKKHKJE??KKIBKKJHK?KEK?IKKKHIKKKKBKKJKDK9KJKKKJEI?KKEKIKJKJKKKKJKKJKKKKKKKIKKJKFKBKJKIKJKJCKIGKKIKJK9KKKKKHKKJJJKKEKKJK;KJJKJ:KKCGKIKJKIKEKH3KKKKKIIKHHJKGKKKIKGKKKEKKJ=KKIKKIJKKKKKJIKKKKKKHKHKKHKJJKJJKKKKIIIKJ&GHKKFKFKKKIKKJJKKKIKKGKKKKHJCEJKK%JKKKKKKFKKJK(KKKKKKKIK==KKKKKKKJKKHKKKKKJIBKKKKKKKKKKJEKIKKJKKKKKJIFKIKGKJKKCKGK7KHFKJKKKKKKKEKKJIKIJKKDKKHJJKJJ*IJJC+;J8KKKJDKKGKHK9KKJKKFKKKJKJKKJCKKKJKKDKKKKJKKKGIIKKGKK0KKKKEKKCJJIKGJKKHHKKFGKKKIKJKKKKGKKKKKKKKHKGKKKKKKKKKKKKKKKIKKKKCKJFI/KKKKKKKKKKJJ@IFJJIJHKJKKKKJJKIIKK?1KKKKKJKKKKKHKKKKKHCCKKKKKHKKJKJKKKJKKKK9KKKJKKKKKKBJJF?KKGJJK@KKKKKKIKJKKKHKKIIFKHJCKKKKGKKJKKKKFEKKHAK/GKGJKKKKJJKKGHKKGKKHKKJDKJEH;KFJF;:IKKIH&FIIJKKJKKKJKJFFJKJG5HHG@KKJDKIH4KKKKHI&K@KKJ:IKI@KKKCKKKKKCKKKJKKHK@KKJKKKKDKKEKJJKKKG2HH;CEIJDDJDDA?JI+FAGADDKC=I>>3GG>EIII8HJKIIHJ;EE0EFGGF%;>H?IHJFF=ID;EGDHI1GIBII/I3K95J8E3E=DIFD'GFJKFJ761K1HAGB2@E/HJIJB;CGFCHKD5C;BJJ8DI?JHFFCF7KJ1KEII9E=K:KII2K:G=(EDHJ@K=JID8FF@E@EKJIKAFJKJ+KH&K=K>J8:@I;KK9DGKIH>HBAD8>&IEH-IGHI;:J,KGKJCGJ3IAD19A1GJIH@BGIJ>/B84CCHDG@-FFIG+JG6IGJKKF7=K&FF;C@BCD2J7DB*IFGDDH/K3IFJBJKJHGDBK1K>E;FB?GIKCFIJ6KIGJ@<=EK=9JKEIKHH0KIEHHCKJDFCC=HIF?CH>GH3EIIKGJEBHFJHCGJKKKFJ:GADJIJHJJJIG3KKCJI8K8JKGHDJ@E?H?IHCKHGH/IJHICJJJFKIJHIJIIDJ:JHJFH>J5A0CHFK/JJJH4J@FJIIIGK4IDA4BIJHIIIJJ9@IAGEHDBHBF>DBHFBFHEIGEIGKK1JJDIGC+6D@DII:JKC3A.KH2:2B4KI?J&IIKGA6>@C7CFCDDG7<(ECGHFIFIG9/F7K0KIGB%DB@3C#1DAAK@KFD6CFIHC91B;K?H7K>KJKHH9DIAJGF>8IJ>IEAIA(HJJ/KKKBHAE1KJ;K.IIKH12HI>?F&JA2HH@H;7+K%7HHAJ;HDH2KI>KH*KIH/E(GG?:FH6FJE'C9DG>G)ICF?0D=?G'E>I1CI@JB1GJFJKG,HKHG91HKJ9IFEJ?J.?1G6IHJ4JIKG-IIHAHBB%D>JCK6FGK9JDKFKKKD+KKKJGHKKKJKEK>KKKKKJII4K>@IAHJ>JI1-A,J/HJK;JKHEK7KK0JHGFEE'=IK>JJD$C9-@KJI*FGJKJ7GBKHE5K='EGHHD+J('K=;.DKHK5=)IKGE@7K:?F<)JEHG?GC0F310=IEJFIJG=*IKJJKII<5JK-IJIKJKI;9K:KKDJ@JJKB1GJCJ6KKKI?JIJJFK:KJF6H.$FHGFJKFG?JEIEH+GIGBJ7HH1IHGF;KK)HJK8/GDAGGGGBJ:KACI;JFFHJCJJCGDJG3KKB$10:=#@BF1G=KKIIK-JED5KJH=C?IJC2HJIGIKHJH-IFJIGKHA$B1J8>E'GHKHKHHDK9->KB@KJ3K-8EI4AJFBKCKJFJGJIKKFGJBGDKAIK)KKCG3K(FEFF9HGHB&KKK%JIHFJK?KJKIKKI@IB?BFCBG'J>KJIFKJJGJEGIKII2GIAB.JFJDJIF:I4IFAKIJK3JJ4C;JIF?JJJHKH3KK)KKJF3/KK&JIEFF7JADJCK?KJK9)CBC.JID*IKKKK@:EJ%IJIJJ@IK3KKJ'JHHJHHJ'HJJ?KF)KKK$GJ&JHG/CHE*KHJAAJK??I*KFCH0>KKKIFH@KF.JFJ@:KCE,I(FFJ*KHAE+HJEF*EJKKKIIHI8>K+I&HKK8I9B,B7B+BKGKCGKG4JAKIDJDEKI/KJJEB@:7<27H5KBA2KKKBBG4=F>HKBKJGH?),?AEGDHHKFCEFDGJ&K5IIGFHHAFK@JFCF1AIFAJB9959K-@;IJJK5EG?1HKKKK3HKG9IH&JI&EJG9@JEH@KK.H67I)JGKF2KD$:JKHKDKI)>KIFJIK2FHKHFH0JKJDKKK@FGKJKJD6JCKKDK>IGA4HJKJKKCBAJJIKBKKIJ@FKJJJ?FH7JHE3CC?JKKKCKGIFJFBIK8AFK4KHJKIKCIJA=KK7KKE)>H1>IJJEAJKB5JJEGGKKKJK?KDDJ$IKKKJ0KEKKKJJCJKBFK;JIEJID=KIJ=KH6K>GC%JGIFGGH@7B5DFK%KJHGIIJE>7GJBHCKJJF;J>GBJKIKJI=EKKBAHHKEJEGKFJIK$9=8FHJCCCJ8BGIGKGFKFJ9K7DJJJJGIJHJ1F7GIKJIKGKFK?@JKHKHFKK1GJJFJGFJHDGJFEKJHGJ@JFJF?D=?==KK7BJGDJIKK)K;JIJIKFKBJHKGH;KJKKJJ)KJIKB@GEA;GFA>CC&:G2IAHAIHFHB$&(=BK@,HI8FKHK?B9KKHBKHHIJKKK8>GABBBG8ACJAKDHIIJ8HGEGK7KJ7EIHKJ?BJIJ*C6EGEK7BE:2=?@DIDHEIK:GKAKJIGIKKKKJJJFBEKFH0IGD?KIKKEKFHKKKK?KKKBKGAKKKK'FKCKHK-FGJJ,KJHHEECJK@IKICKKKJJ9JAKKKKKKCIIKJJJ4KIE>EBFIEJKIKKKEHK4@JKKKK=IKKKKKJKKIJEDIJJBKKKJHJIIIJKHFHKHIJGKDJDIIJCFEKKKKJJDKKK8I-CK7;GKJFHBKIJAK?IIKD.K;K1KKK9KJKKKJJKJKKJIKG95IJKAKKKKJHKKK+I*KEBIJKD3KFJ=HKHKIJKDKHJKJJKGDII=EHHIAHKK.KKGKGGKKKIII@J>KHKKEK=IKKGK1JK8IB?KKG&:;JCJEIJ@K>AKEJKHIKBKKKKKKJKAFIDH5HKHKJK>KKKK1B=D#GJJCJKHKIKIHG9KGDAHE#K?J @rCer/2028/24_1865_CCS ATGGGGAGTGCGCGCGGTGATGGAGCGCTAACCGGGGGCGCGGCGGCAGCGAGGACTCGGCGGGCCATTGGCTACCGGCCGCGGCACAGGCAGCTTGGGGACTCAGCGTGCGCGGGGCCCGCGGGCCGGGCCGGGGTGACCTGGGCTGCAGCCATGGAAGAACAGAGGGAGGCCCTGAGGAAGATCATCACAACACTGGCTATGAAGAATGAAGAAATTCAGAGCTTTATCTATTCCCTGAAACAGATGCTGCTGAATGTGGAGGCGAACTCGACGAAGGTGCAGGAGGACCTCAAAGCAGAGTTCCAGTCCCTCTTCTCCGTCCTGGAGGAGCTGAAAGAAGGCATGCTTATGAAGATAAAACAGGACCGTGCCAGCCGCACCTACGAGCTGCAGAACCAGCTGGCTGCCTGCACGCGGGCCCTGGAGAGCTCCGAGGAGCTTCTGGAGACAGCCAACCAGACTCTCCAGGCCATGGACCGCGAGGATTTTCCTCAGGCTGCCAAGCAAATCAAAGATGGAGTGACCATGGCCCCTGCCTTCCGGCTATCACTGAAAGCGAAGGTCAGTGACAACATGAGTCACCTCATGGTGGACTTCGCACAAGAGCGGCAGATGCTACAGGCACTCAAGTTTCTGCCTGTGCCCAGCGCGCCGGTGATCGACCTGGCCGAGTCCCTGGTGGCAGATAACTGTGTGACCCTGGTGTGGCGCATGCCGGATGAGGACAGCAAGATTGACCACTACGTGCTGGAGTACCGGCGGACCAACTTCGAGGGCCCGCCCCGTCTCAAGGAGGACCAGCCCTGGATGGTCATCGAGGGAATCCGGCAGACAGAGTACACTCTGACAGGTCTCAAGTTTGACATGAAATACATGAATTTCCGCGTGAAGGCCTGTAACAAGGCAGTTGCAGGAGAGTTCTCTGAGCCGGTGACTCTGGAGACACCAGCGTTCATGTTCCGCCTGGATGCGTCCACATCCCACCAGAACCTGCGGGTGGATGATCTCTCCGTGGAGTGGGACGCTATGGGCGGGAAGGTGCAGGATATCAAGGCTCGCGAGAAAGATGGCAAGGGGCGGACGGCGTCTCCCATCAATTCCCCGGCCAGAGGTACTCCATCTCCCAAGAGGATGCCCTCAGGTCGTGGGGGTCGGGACCGCTTCACCGCTGAGTCCTACACAGTGCTGGGGGACACGCTGATCGACGGCGGGGAGCATTACTGGGAGGTGCGCTACGAGCCGGACAGCAAGGCGTTCGGTGTGGGCGTGGCCTACCGCAGCCTGGGCCGCTTCGAACAACTGGGCAAGACGGCCGCCTCCTGGTGCCTGCATGTCAACAATTGGCTGCAGGTCAGCTTCACGGCCAAGCATGCCAACAAGGTCAAGGTGCTGGACGCCCCCGTGCCCGACTGCCTGGGTGTGCACTGTGACTTCCACCAAGGCCTCCTGTCCTTTTACAACGCCCGCACCAAACAAGTGCTGCACACTTTCAAGACCAGGTTCACACAGCCCCTGCTGCCTGCTTTCACGGTATGGTGTGGCAGCTTCCAGGTGACGACAGGCCTGCAGGTCCCCAGTTCTGTGCGCTGCCTGCAAAAGCGAGGCAGTGCTACCAGCAGCTCCAACACCAGCCTCACCTAGGCCCCCAGGCACCCACCCAGCTGGGGTGTTCTTGGGGGAGCCGCTGCCAGGCCCAGGCTGCTGGAGCCAGGCATCCTACTCTGTCATTTGCTGCTTGGAGCCTTAACTCTGGATGGGGGGTCACCAAGAGGGAGCGGGCACCCTGGCGGGCCCTCCTCCCCACCTCACCTCTTAATAAAGGTCAAACACTGGCCAGG + JJ8KJHCBJ8JJKJGF>GJJ+DIKKIDH/5ABI(KC@=>H$+B9>KJK6CBC@D@FKK=KBBHH>IK3GGGFEG:JBJ9@AHAIEBHIGIKJKIGIAHIC?BJHE>IGDJDJI6KA<166ED2F@DD8AIEJ@I>D0ICGKD>EJJJJECKIJJ:5HECA*IKCKCDKKK;K;JKF?HCKGIEJJIKFJ>J2FGA>I2IDCHJH;KG(H@FA9B@B9HKCIJHIC@FIJ4FAI1HDGJJKJGIJ=@KIKJJ@KKKKKIGKI9GGKHKGK9E5GEJH8F6HC.?'GD<;>KF@GKJG?HGCJFJCJ?@H1IBEKIEHC@BHBIAK7GGHJB.EHEEGBFFKHI,HAE?0EBAB@DEJ=HJ/ICKGA5BEBDDBHJAD4@?CBIBKAH0GDIEIFHEKKFIKKGHFGHIKAJGJHH/:51%D=5F2E2H8AFJBJCFKKKI6KJAAKJKCFGJH>KIJI>A@E;F9=;I8JJ:IA?JEGIKEIIKGF>JGFHFDKEIFKKG7IH@BCKBCAAKHKBAIGJFI??IGBBFGABEIK;HBIAGJ?EH:FIKKKDJKJFI;4AE(F=>ICHF?H64AIDACIFIIH>DHACDF79C@GF?J=IHGEA3DHBI:HGAKJKKD9AKFGJH:FIIEGF>JG=IAICF:@CDEI;0KFDK9FF8GBKJEF>>CDHA?IKKGG8KIK;KJFBKHKJKJ>KGFKHCKIFJJ5KICHCHBG?BE?KHFI>KKIKKKCKKJKJKGKKHHKHGAJJGEIIG5AIHCEJJKKJE@CEIHC08BIKFJDHKKIF@IHKHDJKFBHGB1E6IFHIJJ=BBBEK?JIKJ@E4IKJ?KFJGJJ==9?AJJJIGH@KBEH7DJIKI?HDKGHEI>IKIFJKGJIK>HKJEJ?DIJJ9JBBGF?IC7KJGJEHEKGDEGHEKDJHKIKKIAKGHAHBKJKIJJBK8GB@KEGFI@K6IGKIBD<+2?=CJJKI@:KAIE=B=@@FG8KKKKI>KHGGHHIBEG:EF<0E====?D9=5:JKK@CCGHDFBJ>IG:J/D?A=J>DBA=B?C:?G<5EEF,?K287AGHD=DB-CDAEH@KJJ;J@IHB2<;=C@HBGG8A1BADCD<>D0CBIJI:JEEFIDK@FDJJKCAJ?II?CJFDCDB;(>CCCADB?F?=@??6;7'AB65<=CAEE87?;5B;7DCFEBA@A@;=9,??DA=C?7@9C=C?B@EFFBCD@6DA?A9<3;>ADAE0:@5>>A)<:4=BCA8;AA<3D2E?C=BE:BB4D=ADC?GFEDG-C?BED>A?;A(@CBE?E>@2A=5GGH?:<1H?B2DC@?:HFGDC7@55B>D4BF=??HEIAG8B9@:3ECGBHD;FGC7GG9H?AAF??HDHBHGDE(:9DB>7<:(<@BGFGCGA=;.8DADDG8?AFC?G=F7>D?DA>D?GHFB<9?DE>>=B?>F=/A=9<9AD99C5EBCDDA?79;E2B@AFG2?@C?HA3EEB@=8B5@C?E:=>9A8?CG-?1==8+>?A=7B>E3A54AC:&;:@B+B@@BC<$?<:BC@?BD)A798AE6AD:>;D;DF;B>.?95>AFCCEB:H@I2HFCEDCFF?7B,GHE;DE;F1F%GG?8@:@0A@@GG>IIB7AGB@=IIDGB@D@6E>>G>5>>AE8DFEFBG9G7BFA?C@>ADFFFBE@DE)B<@=FEFIIF@:0GG4DB5EB?9FGCF;@AC:FF@IEG@GBEDBD>ECB8GF9IDC<5CDHEGIJCHDJHIDD@8@;@;IGJ>=JHFH?HFI>IJ?DJFIF?1AG9H9HIF@D@DFE;FHHCF>9C;ABAAEGCH9GJ9E=?ABDC9==:7D;@=?@A5>H9EEGD@AIG9F:CCAB?=D@@4,@DB?HC=DFD?2DJHHAF?IFD@8EBBEA5F%B35BC1GGF69EB==IHDG@(D?B8@C=DAC@ABACEDEBC;=C9;:>E3B;@I9HIGDHDBEGA:FHIIFE8HFHGECCDHB:II>A?0FHEEFBDD7?EC4HEE9FA>@HDG>=?=;EGHBDE=F>JGED9;,;BC=BIF<=DHH8HG@EE:HJG7FGHFHH?HCFF1BB@-FHCDA9CIA@;BHGAGB@8C>>FHEE8I:IFECIFC8HG7=@GA>EFG@5=FCDC/@:3FEECGA4DHG@@6;D:C=2,FECBGICDJFCD7ED?G@DEDEFFEFHEIE@IE=DF6%?AB?CCACEG??AABH6HHH6D5JICG?GCABG;GHJIF@D;6@C3<7C5CF;BJID=?HEEGGFEG?F9#G@>B=B>C?<>76??:F>IFBFD>,HEGF@GBJB;==?BC=7@@FDCCC>=DCD:=?GDBHF>D>HEEFBDA?5BE9=BDEFCD>ADB@G;B@AICGGDBD9G=CH5C>CGFD@HCH@D@GCGD;H:9B@GH=5E5;C2DGGAEAB<:;H4AHC>;<@;JJGADDGFEGBFCGD(=>CBIHHF/CECIC=>@BG>AEA4DEBCGCF*ED<:5CC6@C<4BC>@9>;B@::?FDCE>?@BC;A;EDE@9=9D@@?8@@?>=?:D@ABE@5A09@0:EEBA1ADE@=?899CE@2:30ACBCEEGGA?GADE;A@115>F7A>8@GCDE?DEEB@=;>;D=D/GFCDBACB:CA?CEA==DAC@=1=6BBD:D+C@<8=>A;E=CA:D97@>BB?;@<9=2>A@@5=692A0*=:16?:-@@>>; @rCer/2034/25_1735_CCS ATGGGGTAAAATCCCACACCCAAAGATGGGGGCTACACTTTTATTACTCTGAAGGACAAGGATGTCTTTTAAAAGCAACTAACTGCCCACATCCGCACACGCGCGCGCGCACACACACACACACATTTGCTCACACAAACCACACAAACTTTAAGCCTTGTGAAGCTGCCCAGGTGGTGTGTAGGAAATTTTGTAGAGAAAGAAGTGAGAAGACTTTGAGGCAGATTCTAGCTGGCAAGATATGACAAAAGTAAGATCTGGTTTTATTTATTTATTTTTTTATTTTTGTTTTTTCGCAGCTAGTTTGAAAGTTGGTTTCTGACAAGAGGAAAGAAAAGGCTGCAACAGTAAAGGAAGACTCAAAGTGTTAAAAGGACTCTCAAAATGTAGTATTGTGGCAGGTCGCGCTTCATCTGTTTGGAATCAAAAGTGTGGAAAACCTGGAAATTATGTTATAAGGATAGCAGAATAATCCTCGTCACTGACAGGTGATGAGCTGCACAGAGTGTTCTCTTGTCACAATGGCAGAGATTTCAGCAACAGAGGAAAATCCAGTGGTCAAGATGCTTACCTGTCTCGGTGTCCAGCATGTGTCCTGGAGAAGTGCCCTAAAGCACCTTCAGCTGTGTTTATTTAAACACTTGACACAAGACTCTGATGCATTTTAATTTTTCAATGTTTAAATTTAGCTGTTTTAATGAGGTTCTAGTTTTAATAAGCAACAAAGATTTTTCAGTATTATCATGAGACCTTAAACTCTGTGATCTATATAAAACTCAGAGAGAACCTGTCTTGAGTAGTTTAAATCTCTAATTAAATCAGTATTTCTACCTAGCAACAGAGTAGCAAAAGTATTAATTCACTGGTTCTCAATAGGGTGGGGGAGCAGATTTTGACTACTAACCCAGGGACATTTGGCAATGTCAAGACATATTTGGTTGTCATAACTCATGGAAGTGACAGTGCTTCTGGCATCTAGTGGGTAGAGGTCATGGATGCTGCTGAATATCCTGCAGGCTCAGGACAGCCCTACCTCCATAAAAACTTTTCTGGCCCAGAATGTCAATAGTGCAACTGTTGAGAAACCGTCTATAAAATGATTGGTGTGGGTAGGAGAATATACTAAAATGCTAAAATAGCAGGCTTGAAATTATTTGCATATCAGCAGAGTGGAGTTTATAACTGACTGACTAAAAAATCTGGTATAGGACCTGTCCTCCAGGGTGACGCTAAATCTGCTGATATAATACTAACTCAGCATCTGTAAAATTAGAAACATATCTCCAGGGTGGGTCAGACCAAAGAATGGTACACGTCGCTTCAATTTTAAAGAGTTGGAAATGATGTTGCTCAGAGGAAATATGGGTCTCAGTTGAGCTGTGAGGTGGGGCAGGTTGCTATGTTTTCAGGCACAGTGTCTTAGTTAGAATGGAGAAGCTCTGAATACCCTACTGAAGTAGTCCCTGCTGCAGTGTTCTGTACCATGACATGCTCTTTTGCTTTCTCAGCACTTTTATAAACTTTAAATTAATTTTTATTGTTCATGTTGCTATTGCTTTTAGTCTACTCTCTGTCTATCTCATTGGAATGTAAGCTCTATGAGAGCAGTGACTATATGGTATCACTTAATATTGTATGTCTAGTAGCTACCAGAGTGCCTACCATTATAACAAGCATCAATAAATTTAACATTTTTGAATTAAATGAATG + JK:KKKJ5KKKJ,JK=GD%GI=JKKJK/KKKKJKIJGKGKKKKJKKKKKKKKKEKKKGKKKKKKIJ+KKKBKKKKKKKKKKKKKK4KKJAKKJKKKKKJJKKKKKKKKKGIKKIGJKIEKAKJGKKKKKJKKKKKKKKKHKKKCKAKKK@KKKKK=KHKKKKKKKKKKBKKKGKKEKKKKKKK.K&KK8KKC2KKKKKHKKKIKJKHKFAKFIKCKKKK>KKKKKKKKKKKKKBKKKKJKI@KKKKDKKKKKJKKKKKKKK>KKKK>KKKHKKK*FE@KKJE*KKKKJ%KKKKKKKKJKKKKKEKKKFKKK7K4K0KKKKKKKDKKK8KHKKKIKKK?KKKKKHKE>KKKKK,KKKKKKJFKKKKKHJDKKKK@KJJ8KKJJJKKJK'KKK9KK5K=KKHKKKKHKKK6KKKHKKKKI;KKK=KA>KFGKKKKGEHKJKGKKKKKKJGKJKKKKKKKJKKJKKIGIKKKKKKKKKEKKKKKKK;KKKKKKJKKKKKIKDKKKKFKIKK@KKKFKKJKKK@KK0KKKKKKKEKKJHIKKKKICKKHKIKJKKKJKKKKK4KKKAKKKKD@KJKKKKKFKIJ9KKKGKK;KKKKBAKKKJGK2IDKKKKKKKKKKKBKKKIK:KKKKKKKJKCKKHKKKKKKKKKKKKKKKKKKK=KKKKKKK-KKKJKKKKKKCKK%KKDJKKKKKKK9KKKKKKJKGKKIKKKKKKKKFKKKKKKKKKKKJKKKKKKKKKCKKJJCKJKKKKKKKKK0KKKKKKKKKKKKKKKKK3KKKKCKK@KK*KKKKKKKKD)KKKIGKKKKKKKKIKKKKKKKGKKKKKKKKKKKEKKKIKJKFKKKKKKKKKGKKDKKK#KKKKKKJ/K@KKKKKKK=KKKKJKKKKKKKKKKKIKJKHKK+:KKKKGKKKIKKKKKFKKKKCKK%KKKKJDKKKKKKKKJCKKKKKFKKKKKKKKKKKKKKKKKKKKK7KKKJKKKKKKKJKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKJKKKJKKKKKKKKKJEKKGKK%KKKKKIKKIKJKKKKKEKKKGKJKKKKKKGKKJKJKD>:8C?@3DCD?DB???>?>:@BADBC@BCBDDCB5B@BDDA:B?A<>BCA=;AA?CA;A=@@<<;=@+AA9C<0>EDD?@D:DABBB>CA>7B8B@>D?A5CD8A:ABA;>?;?:<<:8A=<>C4E=EBA@=DD@ADDBBC<2D9>.E?=?=@C;BC=?9@:A?G?=EBEBA7@FB?5?@;CBDGABBEDD?BA;<BB@;BAGA?B>>B1?B1;ACA7FC=D:B?DBGC<@D>DDAACCCB/?ABECEFE=DE;8BEEEBAC6;@BC<2@D@?DE0C=FG:C??6>D?5><5=BDC=>@4A>DE@;?>ACGB@C?D:=BABG=FEAEE7A?ABC2B=C@5>B>&CCC=>B;CCBFDCEFE@C3=4AEEBEC>>4C1B@@B8=;@=A@CA4@>C=?FAB,B8;?@>@B@3>7;9@:A>787>9;AD?AE=7:ABB>'B5>D;C?A>@A:C;D?>@?B<=?C;CA@C?@=>@@@===?BBABAA2#;4@;ABE:A>@CEFD??B6:CCE><;FB@D><6A:AC(B9CA@B?A?CCC@B?>69;EA?GABDFF@/??FEDB=@?@/87B@CDDC:8>@E?8=@AA=?FE>2D?AFA?DB>B8E8:FFFAB<;BED@EACCEEDFCBB>=B??AB>D7ADB>C;;EE>916B>8BD1EADBAAA@CC1A5:A<=EECGC>??;D@0DFCCCC6EADG>EEBB?B@?=2;38>D@EBB?FA==>E6;A6F:DFB8:+>B6=8?=<0?9>A;98;7=?A?<<<7=6=C?B;8?B@;@A<>:9;??@8@=>:@@B>8@:;?9<>6A@?A=BB@>??A@@C>B?>?=;;%<0>?:?9@B@8:<,=A?=B665=>>=AB::;7B8AB>@>>B;?;-@?992@;B?A??@945<8?9=A3@<9C:=<@>@996;;79<79A>C?:><9@;87@?:7/=<6AA;?8??79=8=<9@>@?><3'(4;9;,:389<6?A8>?>8@895*>;6;0@;;57>+96>><368?C;A:@4<7>@9>;:@%;9987;06<784>><@=6;BA?C1>;B@@8=?>@-@A=>;78>>?461;7<8A2?;?;?B>>@=><=:=??:@@?9?/>7=>9=>@99:@C:<8A>8:<5?<:18;8B?;?@5<=?-9>/?9<@B=9*<=:874>>A-=AB>?0=<>=9998297==;;=7A@?2A>?=59><@C?-A?<;B?,849>=7<7;9>43;:3;?A>=72?6@C4@<<::;79;A=/97@8;.;<<(@A;<<7B=>?>3;1463>19256AC>>=:>)6=8@9?@2>=3<1<>>::8<<89;79;6)-151.=C9AAAC9A@=7?@;<<)<56AA@6;9/;BA@36<>;;??7A9>?.;A3:26;869>?+9>9BA<:3;;;8>>2@@??:==<7:;&>?AA83>;/2:=0846478#=C=>@4=3==A>>@@F@>@@01AACE7>3F@0KKKKKKKKKKJKKKKKKKKKKKKKKKKKKIKKKKKIKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKIKKKKKKKKKKKKKKKIKKKKJKKKKKKKJKKKKKIKKKKJKKCKKKKKKKIKKKIKKKKKKKKKKKKKJKKKHKIKKKKKKKKKJKKKKHKKKKKKKJKKKKKGKKKKKKAJKKKKKKK1HKKKBKKKKKKKKKKKKKKKKKJKKK(KKKKKKKKKKKKBKKKKKKKKKKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKIKKKKKKKKKKKKKKFKKJKKKKKKKEKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK9KKKKKKKKIKKKKKIKIKKHKKKKKKKKKKKKKKKKKGFKKFKKKKKKKJKKIKKKKKKK@KKKKKEJKKKKKKGKKKIKKKKKKJKHKJK8KKKKFKKKJKKKKKKKKKKKIKKKKKKKKJKKKKKKKIKKKKKKKKKKKKKKKKHKKKKCKKKJKKKKKKKKKKKKIKKKKJGJKKKKKBJKGKKKKHIKBJKKIKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKJKKK=KKKKKKKKKKKKKKKKKGKKKJKKKKKKKKGKEKKHKKKKKKKKKKKKKKKKKKKDKKKKK @rCer/2039/0_1616_CCS GTTTCCTCCCATGTCGCGGCGCCGAACCAGGGGTGATGGTGGGATGGGCAGATGGACTCCTCGTGGGTGCGAGGCCAGAGCAGGCGGCTCTTGACCTGAGTACCTATGGGCATGGATTGTACCATGGGACGATGGAGAAACGGCACATATTTCTACAATGAGCTGCGCGTGGCAGAGGGCCCCGGTGTGTGCGAGGCCCTCTGCTAAGGCAACGAGGAAGTGATTATGTTGAGACTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCTCTACGCCTCTGGGCCACCACTGGCATTGTCATGGACTCTGGGACGGGTCACCCCACGTGCCCATCACGAGGGCTACGCCCTCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGACCTGACTGACTACCTCATGAAGACCTACGAGCGTGGCTACAGCTTCACCACACGGCCGAGCGGGAAATTGTGCGCGACGATCAAGGAGAACTGTGCACGTCGCCCTGGACTTCGAGCAGGAGATGGCACCGCCGCATCTCCTCTTCTGGAGAAGAGCTACGAGCTGCTGATGCCATGTTCATCCATCGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCGTCTTCCTGGCATGGAATCTTGTGGCATCCATGAGACCACCTTCAATTCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTGCCAACACGTGCTGTCTGTGGACCACCATGTACCCAGGCATTGCCGACAGGAGCAGAAGGAATCACCGCCCTGGCACCCAGCACCATGAAGATCAAGATCATCGCACCCCAGAGCGCAAGTACTCAGTGTGGATCGGTGGCTCCATCTTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCTCCATCGTCCATCGCAAATGCTTCTAAATGGACTGAGCAATGCGTAGCATTGCTGCATGGTAATTCAGAAGTATAAATTTCCCTTGGCAAATGCATACACCTCATGCTAGCTCACGAACTGGAATAGCCTTTGAAAAGAATTGTCCTTGAAGCTTGTACTGATATCAGCACTGATTGTAGAACTTGTTGCTGATTTTGACCGTGTATTCAAGTTAACTGTTCCCCTTGGTGTTTGTTTAATACCCTGTACATATCTTTGAGTTCAACCTTAGTACATGTGCTGGTCGTTTCGTGGTCGAGGTCAGAACGTGCTTGTGAAGACAAGTCTGGCTTGGTGAGTCTGCATGGCCAGCAGTCTCCGATCTGTGCAGGGTATTCATGTGTCAGGGCTGAGTGTTCTGGGATTTCTCTAGGGCTGCAAGGGTCCTGAACCAGTTTCTCCCTGCCGTCTGTCAGGGTTGGAAAGTCAAGCCAAGGACCCAGTTTCTTAGCTGACGTTTCTGCCAGAACCCGTGGGTGTTACTTGCCTTGGTTGGAGCGGTTTGCATTTACACCTGTAAATTATTCATCCTTTTATTTATGTAAGGTTTTTTTGTACGCATTCTTTAAGAGATGACAACAATTTTGGTTTCTCTGTTATGTGAGAACATTGGCCCAGCACACGTCATTGTTAAGAAAAAATAAGTGCTGC 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rCer/2043/0_3069_CCS GCCTCTGGCACGCAACGTATTTCACGGCTGCCTGAGGTCAGAGCTTCGTTCAGCAACAGCAAGACGGCCCACCCGCCCGTCAGCATCTCCCGGCGTTCAGCCACGGGTGTCCCGGGGCGTCCCATGTAAACTCTGCGTTGATACACTGCTTATCTCCTCAACAACTATTCTATCCAAGTGCGAACGGAGAGAATATAATGTTAGAAGAATAAGCATTGGTCCGCTTGAATGAGCACATAGTTACTAGGTAAGGACACATCTGTTGATATCGAACACCGGGCCGGACGAAGCCGGGTAGTGAGCGTGGCACCTCTGGTTGAACCCGTGGAGCGTGCGAGGTGGTCGTGTAGCGTCGGGTCGGTGAAAGAGCGAATCCGCTGCACGCGTCCAGGCGCGTGAGACTATCTCTCTTCGTCCGAAAGATTGCAACATCACGCCGCAACCGCGACCTTTTGCCTCTCCGCGTGGAGCTGGTTCACCGCATCGCCAACAAGGGGAGCTCGGGTGAGGTCCCTCAACCGGAAATGCCATCAAAGGATAATGATTCTGCAGTAAAGATGTTGCTGTCGTTAAAAAATGATCTACAAAGCTGCCATGGGGGAGATACAAGGCTGACTGTCCTCCAGGGAACCAGCACTACCAGTAAATCATGGCCCAGATGCGCCAGAAGCTGAAGAATTTGTGGAGCGCCAGATGAGCGAGGTACAGACTCAGCAGGTGCAGACAAAGGCAAATAGACGAGATAAAGCTGAATTGTCTCGTTTCGGAAGCAGTAAAATTGGATGCTCGGACTCCTCCTTGGGCGACAGAGCGTTAATAAACCGGGAAGTCACAAAGGACGAAGCACCGGGCCAGCGAGCACACCGGCTCCTGCGTGGAGGCCACTTCTTCCAAACAGAGACATGAATCAGTCCGATGCCTTTAAGAAGCCATTTATCTGTACACGCGGGGCCCCGTCGAGAAGCCATGCAATGTGGGTCATCTGCATTCCGTTATTTCACAAAGCTGGTCCAGCATTGTTTAACGCGCCTTGGTCAATCCCGAGATGACGGTGACGAGAGAGTGCTTGCGGCAAGGACCTGACCCTGTGGACGCAGCGCTATGGCTAATGCCGTGAAATGCAAGGAGAGAGTGCTGTGCTTTGACATCAATACAAGACTTTCCAAATATCTCTCCGTGACGCTGGACTACATGGGGCGATTGAGCCAGTTTTCTAGAAAAGTGTGGGGTGAAGACTTCGCAAAAGCATGTTACCTTCAACACAAGTTGAAAGGGCATTTTCGGCTTCACTGTACAGCGACAGCAATGGGAAGATCAGTTTCCTCGCCATCCTGCCCAGGTGCTCCGCTTCCTCACAACTCATTCCACATTCATTCAAATATTATTAAAAATAATATTTGCCTTAATCCACTTCATATTATTTCTCAAAATCTTTATTGTTAAAAACAACCTAAACATACAGCGAGGGGATCGCCGATACAGACAAGATATCGACAGTGCCTTAACCCGATATGCCATTGAGGACCAAGGAGTCCCTATTTAGAATGACGAAGCGAAGCGCTCAGCCGCCTCAGGGCGGCTACCTATAAACACACCAGACTGACTGCATTCCACCTATCTTCCCTGCCCGGGCAGGGCGCCAGACCAAAATGCATGCCAGCGACCCAACCCGCCAAGTCACTGACACAGCAGAAGCAGAATCGATAACGAAGATCAATAAAGCATGGCGTTTTGCTGGAGGAGAGACAACATCGAGGACCAGGCATTGGGGGCACTGTATGTGGACGTGTCCTTTCATGTACTGACTTCTTCCTCGCGACGACGACAAGGCTCGAGACAGACAGAAGGATACACAGCCGGAAAAAACAGTTCTCAACCGTGAGCCACAGAAGGTACCATAGAGGTTTCTCAGCCGACGACAGAGCTCCAGGCGCGGGCCACAGGGTCACGGCGCACATAGCAAAAGTCATACTCCACGGGAGCTGTCTTTCGACTGTCAGTAGCCACGTTTACATTCTTATAGTAAGAATGTACTACAATAACCCCCGCAGTCCAAGCAGGCGCCACCGTAGGCTTCTGGGCTCATAATATACGCGCCTGGGTCCTTCCCTGTTATTATCAAACTGTCTTCCTTGCGCCTCATGCCAGTCGCTGGTCTCTATACGGGCAAAGCATTGGGGTGATCGCGCTGCTAACATCATGGTCCAGATGAGAGAAGTCAGCTGTGAAAGTCTCTCCCCAGAGCAGCCCCAAGGAGTGAGCCTTGCTGAAGCATTGGCTCCCACCTGTCCTGGTCCGTGAGACTCCCGTGGTCCGAATCATACTCTTAAAGACCACTCCGTGTTAAAACTATACCACTTCTCAGTGATAAGGGAGAAATGGAGATTGAAAGTCATTATTGTAACGCTTAGAAGTGCCTTAAACATCGCGATTGGGAGTTAGTGAGCACACAAGTTGTATTTACGCCCACACCCCCTCCCAAGACAGACAATTGGTAGTACGAAAGAGCTTCTCTGAGTACATTGACTAAGAGATCACCCAGCTTAAAGCCGCTATCTTTAACACTCGAAGATCTGACCAGAGTTGGGCACAATTTGGATGAAATGGGCGAGGGACTGGATGAAAACTGTCCAGTTTACGTCGGAACTCACAGACCATTCAGTATTGCGGAGACGACCCCGGCACCCTCACTCCAGAAATCAGCTCCGCTCCTTGCATACCATACTATCTCCCGCCAAATGACCCTAGACCCCTGTCGCCGAATCATGGTCGCTTTTCCCCTACTGTGTGCCAATCCAAAGGTCCGCACTTTGCAGAATGCTTCGTTTTGCGACCCCTGGCTGCAGGGAAGTCACACAGGAGCAGTGCCTCTGACCCTGGAGGGTGACTACAGGGAGAAAGCTGACGGCAGCACGCCTCGAGCCCTCACGTTCTGGCAGTCCACATCTCATCAACGACCAATGACAGCAGTCTGAAGACAAAGCCAAATCTCAGGAAGCCCTTGTTGATCTCTGGCCTGCGTCTGGAGCACCGCTCCTGTCCACCATAAGAGTAAATAAAACTCCTGCC 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@rCer/2044/2043_54_CCS ATGGGAGCAGTGGTATCAACGCAGAAATTCCAACTGGATTTTCAGCAGAAAACCCCGTTTGGGTTTCCCCTGCCCCCGCCCCATTTGCTGCTGCATTCTCTCTTAGGATTGTGAAATATATCCATGTTTTGCTGAAATATGAGCTGCCTTGTTCTCCCAGTGAGCAGATTACGTTTAGCTCAGCGATGCCACGCCCTGACCTGTGCACTGCGGGGTCACTTGAACCTAAGCTGCTTTGCAAGTCACTGCTAACAAGAAGTAGCAACTTTTGACTTCTCTTGCTTTGTGGACTGACCAGAACCTTCCAGACTCCAAAGTCCTCAGCATTGCCCAGTTGCAGGAAGGAGTGGCGATGCTGTGCAAGAGATCTCAAAGCCGCGGCCTGCTGGTTAGGTGTGTGTTCAATAAAATGTCCACACACTTCACTTTCCTTGGGTGAGCATGTCACAGTTCGGCATCGTTCCAACTACTCCGTCTTGCTTTCCCTTGGCCTGCTCTGCTGACTTACATCAGCCACCTGGCCCTCTAAGGCAGGTGTGTTGAGACCCTGGTAGCCACATGGAGGTGTGGTGTTGATTTTGGAGTCGCTGGTAGTCTTTGGCTTTCTACTAAGGAGGAAAGTGGTCTCTTAGAAGCTTTTAGAACAGCGCATCACACATAGTAAGCACCGTATGTGTGTAACTGTTTCTACCAACAGAAAGGGAGCTCGGGAAAGAGATTATGGGGGCAGATATTTTAGGGAAAGTGATGAACTTCTAGTGTGGAAAACCCTAAAACACCACAGAAAGAAGATGAGGAGGCACACCTGCCCTCGCACTCACTGTCAAGTCTCTCGTGTAACTTTGCAGAAATCATCAATACTTAGGTAAGTCAAATAGAAACTCAACTGTTCTGAAATTTGCCTTTCTATTTTTTTTTTCTTTTTTCTTTTTTTTTGGAAACAGTTTCACTCTTGTCGCCCAGGCTGGAGTGCAGTGGTGCAGTCTCGGCTCACTGCAATTTCCGCCTTCCAGGTTCAAGCGATTCCCTGCCTCAGCCTCCCGAGTAGCTAGAATTACAAGCACCCGCTCCCACGCCCAGCTAATTTTTTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGCCAGGCTTGTCTCAAACTTCTGACGTCAGGTGATCCACCCGCCTTGGCCTCCCGAAGTGCTGGATTACAGGCGTGAACCACCGTGCCTGGCCGCTTTTCTTAATTTAGTAAAACTGGCTCAGTCTTCTGAAAGCTGATGAGTATCCACTGTAATGGCTGTTTCCTAATTTATTTCACCATTGCTCTACTTGAACAGTTAAGAGGTTTCCAGATTTTTCTCCCTCAGACTGTAGTCTGGAACATCTCAATGCATACACATTTTGGCAGGTAGAGCTACAGGCTTGATGTGTAGAAGCCATTCTGGCTTAGAGGTATGTACATTTTAAACTTTTCCCGACATCACTAAAGTCCACCCTCTTATACCAATTTGATATGCAGGGTTTGATCTGGATCGAAGGGGAAGCCACTCTTTCCAGGGGTGCAGAACAGCTGCAAGGGGCAGGGAACCCAAGTCATCCCTATAGCTGCAGAACAGGGCACTTGGCCCTATGGTCAGGGCACACTGGACCTGGGATGGAGGTCTTGGTCTCTGGGGCTGGAGCCCTTGCAGGTGTGTGAGCTCAGGGCTGTGCTTTCCAAAGAGCACGCCAGGACTGGGTATAGTGGATGGATTGGGAGATGGGCTAGGGTGCCTCATCATGTTGCAGACAGAAGGCGGGGAGGGCCTGACCCAGATGGCCAATAGGAAAGGGGGACGTGGGTTTGGAAGGCCCTACCAAGAGGGGACATGGGGCCCACGTCTTAGGTGTGCAGCAGCATCTGCCCCATGGTCCTCATGGCAAGGGGCAGCAGGAGCATTGCCACCTCTGGGTGAGCGGAGATTGCGCCGCTGCGCTCCAGCCTGGGCGACAGAGCAAGACTCCGTC 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@rCer/2049/25_2291_CCS ATGGGGACTGCAGCACTAGCCGTCTGCAGCTCCGGCCGCCACTCGCGCCTCTCCAGCCTCTGCAGGCCCAAACGCCACCAGCACCATGGCCAGCACCATTTCGGCTTACAAGGAGAAGATGAAGGAGCTGTCGGTGCTGTCACTCATCTGCTCCTGCTTCTACACACAGCCGCACCCCAACACCATCTACCAGTATGGGGACATGGAGGTGAAGCAGCTGGACAAGCGGGCCTCTGGCCAGAGCTTCGAGGTCATCCTCAAGTCCCCTTCTGACCTGTCCCCAGAGAGCCCTATGCTCTCCTCTCCACCCAAGAAGAAGGACACCTCCCTGGAGGAGCTGCAAAAGCGGCTGGAGGCAGCTGAGGAGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACAACAACTTCAGCCGGCAGGCGGAGGAGAAGCTCAACTACAAGATGGAGCTCAGCAAGGAGATCCGCGAGGCGCACCTGGCCGCACTGCGCGAGCGGCTGCGCGAGAAGGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGGAGATGTCGGGCTAAGGGCCCGGGACGGGCGGCGCCCATCCTGCGACAGAACACGTTCGGGTTTCGGTTTTGTTTCGTTCACCTCTGTCTAGATGCAACTTTTGTTCCTCCTCCCCCACCCACGCCCCAGCTTCATGCTTCTCTTCTGCACTCAGCCGCCCCGCCCTGTCCTCGTGGTGAGTCGCTGACCACGGCTTCCCCTGCAGGAGCCGCCGGGCGTGAGACGCGGTCCCTCGGTGCAGACACCAGGCCGGGCGAGGCTGGGTCCCCCGGGGGCCTTGTGAGAGAGGTGGTGGTGACCGTGGTAACCACAGGGCGGTGGCGTGGATCGCGGGTCCTTACACTGGGCTGTCTGGTCAGCATGTGCAGGTCAGGGCAGGTCCTCTGAGCCGGCGCCCCTGGCCAACAGGCGAGGCTAGGGTACCTGCTGTCTTTCCAAGGGAAGGGGCTCCCATGCGGGAGGGGCAACGGGGGAGGGGGGGGTGATGGTGCCTGGGAGCCTGCGTGTTAAGCGGGAGCTTGTTGAACTGGCAGGCAGGTGGGTGGGGCTGCAGCTCTCCTTAATGTGGTTGCACAGGGGTCCTCTGAGACCACCTGGCCTGAGGTGGACACCCTGGGCCTTCCTGGAAGCCTGCAGTTGGCGGCCTGCCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCCAGGGCCCATGAGCAGGCTGCCGTGGTCTAGAGGTTGTGGGCAGCATGGACAGTCCCCCACTCAGCAGTGCAAGAGTTCCAAAGAGCCTCTGGCCCAGGCGCCTCGGTGAGACAGCCCCGCCGCCCTCCCCACCAGGGCTTTGCGGATGTCCTTGAAAGACCCGGCCTAGAGCCCTTTGGAGTGCTGGCCCCTCCTGTGCCCTCTGCCCTGGTGGAAGTGGCAGCCACAAGTCCTCCTCAGGGAGCCCTAAGGGGGATTTTGTGGGACTGCTGCCCACAGATCCAGGGTTGGAAGGGCAGCGGGTAAGGTTCACAAGCCACCCCCCACACCCTTCCCACTCGGCACCCAGAGGGGGCTGTGGGTCGAGGCCTGACTCCAGGCCTCTCCTGCCCACACCTTCTGGGCTGGGTTCCTTCTCTCCCTTGGATGCCCAGTGCTGGCCTTGGAGGACGGTCATCTGGAGGACGGGGGTAGGGGAGGCTGTCTTTGTACCACTGCAGCATCCCCCACTTCCCCACAGAAGCCCCATCCCAAAGCTGCTGCCTGGCCCATTGCTGTAAAATGTGAAGGGGGCAGCTGAGTTCTCTTAGGACCCAGAGCCAGGGCCCTCAGCTTCCATCCTGCGGGAGGCCTTGGGCAGGCACTGCCAGCGTCTTCCAGGGCCACACCAGGGACTATGGGAGGATCCTGACCCCTGCAGGGCTCAGGGGTCAGCAGGGACCCACTGCCCCGTCTCCCTCTCCCCACCGAGACAGCCCCAGAGGGAGCAGCCAGCTGGGATGGGAACCCAAGGCTGCCCACATGTGGCTTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGGCTGGGATTCTCCTGACGGTGGCAGCTCTCATAGCGAAAGCCTAGTGTAATATGCACCCATCTCATCCACGTAGTAAAGTGAACTTAAAAATTAAATCAAATGAACAATAAACACCTGTGTGTTTAAG 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@rCer/2050/534_59_CCS GAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + %''(-,-,,')+-'(&-/11.'*%$%(&.+00,-/'-01-1--0-*)).(.-1/00,20+.0/.),-'&))(*+++%-0-.+(00*(%,,0/&*+-1001.,1*.20,+(+#0-.*+'/,0,*0)()..01.-,,)&/00..0&0/-2.201-0/+/*-,+'),0.*+,$.01/10/0-.,*.12./,'**,+,+-/%..-12.2.0/1-111//+/1)0,0220'+.01+0.+..10-01/20--),*00112//-00$/101.-(+*,---11--1--*+0,.1*,,(&.,++$.).00/+/20012**,150.4/10)35/6665144645661312,/40++.()-*,.1.466,+-.(/-443.511'1/,1//1442&303,133(.&'.'0/)11/0.*/(&*56,.30*10)*.-*/.,5022433,/1(0551-152+,)*.,0-1,011,,/11*.,+00/(.-) @rCer/2052/25_1904_CCS ATGGGGAGCAGTGTGAAGAAGAAGAGGCGAGAACGACCCCCGGACCGACCAAAGCCCGCGCGCGCTGCATCCCGCGTCCAGCACCTACGTCCCGCCGCCGTCGCCACCATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAAGGAGATAAAGCCAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTCTGCTAAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAAAGCTGATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAACGGAGATGCCAAAACAGACCAGGCACAGAAAGCTGAAGGTGCTGGAGATGCCAAGTGAAGTGTGTGCATTTTTGATAACTGTGTACTTCTGGTGACTGTACAGTTTGAAATACTATTTTTTATCAAGTTTTATAAAAATGCAGAATTTTGTTTTACTTTTTTTTTTTTTTTTTTAAAGCTATGTTGTTAGCACACAGAACACTTCATTGTTGTTTTTGGGGGAAGGGGCATATGTCACTAATAGAATGTCTCCAAAGCTGGATTAATGTGGGGAAAACACCTTTCCCTTCTAGTTTTGAGAGACTTCCTCTTGGTTCCCAGGAGGAGGGAGTCCCTGACTTTTGACACACATGGCCACCTTGGCACAAAAGCCTTGTGGTATGGAAAAACAAATTTGTTTTTATGTCCTCTTCTCCCTTTCCATCTTTCAGCATAGACTTAACTCCCTTAAGCCCAGACATCTGTTGGGACCTGACCCGTAGTCATTGGTTACCAGTGTGTCAGGCAATCTGGACTTTCCAGTGATGCCACTGAGATGGCACCTGTCAAAACAGCATTGGTTCCATTTCTAGATTGTGGATCTTCAGATAAATTCTGCCATTTTCATTTCACTTCCTGAAAGTCAGGGTCGGCTTGTGAAAAGTTGTTAAACAACATGCTAAATGTGAAATGTCAACCCTCACTCTAAACTTTCCCTGTTCAGAGCATCAGATGAAGACTTCATTGGGTTTTATAGTGGCTTTTCTGATTTTTGGTAGTCCATTGAAGAAGGGAGTTTGAAAGTTGTTGTATACTGTTAACGATTGTCTGCCCATGTCCTGCCTGAAATACCATGATTGTTTATGGAAAGTATCTTTAATAAAGCTGGATACAGTTTGGCTTGGAATGCTGCCTCTGATCTTTTCCCACAAGTGGGGTAACCTGGTTTATCCAAGTCTCTTGGAACAGGGTGCATTCTGCTTTGAGGTATTCTGTGTACAGTCTAATGATGATCTTTCACTGATTAATAGTCAGTTTCCAAAACACACAGTGCTAGGTGGAGTTAGGAAGGATTCCAGGAGTAGATTTAGCTAGTGGTGAAAGGCTGGGAGTATGGAGTGATTTCTGTACTTGGTTATGCAGCATTCCCTGCAGTGTTTGTTTTTTGCATGACTCCGAATACATGAAGTGTATTAAATGCAGATTTTTGGTAGATCTGAGGTTTTGCTTGGTAGCTGACAGGAGTCTCTACTTCAATCTGCATTTGCAACCTCTATAAAATTAGTAAATTAATAGACTCATGTCAGAGAGGGCCTGTGCCCCTGTGAATGTGTGCACAATTGTCTATTTGTAAGGTAGATGACACTTTGCTCTAAGTAGACCTGCAGGCAAAGACAGAATGGGGTCTTTCCTGATTCTTTAGTTTGGAGATGCAGAGAACCCCACGTTTCTCTAAGTGAAATGGCAAAAAGTTACTTGTTAGAATATGGAACTTGTAACAAATTGATGTTTGCACCTTAAATTTGCTTTCACAGACCTCCTGGCTGTATTGGACAGGAATAAAGAAAGTTGGAGAC 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@rCer/2055/1911_59_CCS TGGGGGCATGCGCAGCGAGGTTCCACGTGAGCGCCTGCGTTCTCCTCAAACCTAACGATGCCGCCGGAACGGAGAGACGAATGAAACTGACCGGAGAACCGGAGCAAAGCCGAACGGAAGCCGGAACGAGGCCGGACTGGAAAGCCGGAGCAGGGCCAGGCGGCCTCCCCAAAAGCCTGCCCCTTCATCCAGCGGAAACCGCCGGCCCGCGAGCGCTGCGGCCGCTGCGATTGCAGTCGCGGCGGCGGAGGAGAGAGACGGCTCCGGCAGCGGAACCGCCTGACGCTGGAGGAGACAAACCGGCCGTGAGCGGTGCTTGGAGGAGCTGGTCTTCGCGACGTCGAGAACGACGAGGACGCTCTGCTGCGGCGTCTGCGGGCCCGCGGGTTCAAGGACATGAAGACTCGGGTGACTCAGAAGTGGAGAATGAAGCACAAGGTAATTTTCCACCTCAAAAGAAGCCAGTTTGGGTGGATGAAGATGATGAAGATGAGGAAATGGTTGACATGATGAACAATCGGTTTCGGAAGATATGATGAAAAATGCTGCGAAAGTAAACTTCGAAAGACAACTTAAAAGAGACTTAAAGAAGAATTCCAACATGCCATGGGAGGAGTACCTGCCTGGGCAGAGACTACTAAGCGGACAACATCTCAGATGATGAAAGTGAAGAGGATGAAGATGATTTGTTGCAAAGGACTGGAATTCATATCCACATCAACTTCTCTTCCAAGAGGAATCTTGAAGATGAAGAACTGCCAGCCTGCGAATGCTGAACGTCCTACTGTTGCTCGGATCTCATCTGTGCAGTTCCATCCCGGTGCACAGATTGTGATGGTCGCTGGATTAGATAATGCTGTATCACTATTTCAGGTTGATGGGAAAACAAATCCTAAAATCCAGAGCATCTATTTGGAAAGGTTTCCAATCTTTAAGGCTTGTTTAGTGCTAATGGGGAAGAAGTTTTAGCCACGAGTACCACAGCAAGGTTCTTTATGTCTATGACATGCTAGCTGGAAAGTTAATTCCTGTGCATCAATTGAGAGGTTTGAAAGAGAAGATAGTGAGGAGCTTTGAAGTCTCCTCAGATGGGTCCTTCTTGCTCATAAATGGCATTGCTGGATATTTGCATTTGCTAGCAATGAAGACCAAAGAACTGATTGGAAGCATGAAAATTAATGGAAGGGTTGCAGCATCCACATCTCTTCAGATAGTAAGAAAGTGTATGCCTCTTCGGGGATGGAGAAGTTTACGTTTGGGATGTGAACTCAAGGAAGTGCTTAACAGATTGTTGATGAAGGCAGTTTATATGGATTAAGCATTGCCACATCTAGGAATGGACAGTATGTTGCTTGTGGTTCCAATTGTGGAGTGGTAAATATATACAATCAAGATTCTTGTCTCCAAGAAACAAACCAAAGCCAATAAAAGCTATAATGAACTTGGTTACAGGTGTTACTTCTCTGACTTCAATCCTACTTCAGAAATCTTGGCAATTGCTTCAGAAAAAATGAAAGAAGCAGTCAGATTGGTTCATCTTCCTTCCTGTACAGTATTTTCAAACTTCCAGTGGTTAAAAAGAAGAATATTTCTCATGTTCATACCATGGATTTTTCTCCAGAAGTGGATACTTTGCCTTGGGAATGAAAAGGGCAAGGCCTGATGTATAGGTTGCACCATTACTCAGACTTCTAAAGAGACTATTTGAAGTCCAGTTGAGTCACAAGATAAGCCTGTCTTGATATATCGTCTCAGAACTTTCCGAATGTGTGATAATATATGGAAATGATTTATAGAGTCAGTGTGCTTAAGAGCCGGTAATGTCTTAATAAACATGTGGCAGCTTTTGTTT 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@rCer/2056/0_2269_CCS CGAACACTGCCTGAAGAATGCCGTGCGCCACAACCTCAGCCTGCACAAGTGCTTCGTCCGCGTGGAGACGTCAAAGGTGCCGTGTGGACTGTGGACGAGCGGGAGTATCAGAAGCGAGGACCGCCAAAGATGACAGGGAGCCCACCCTGGTGAAGAACATGATCTCGGGCCTCAGCTATGGAGCACTTAATGCCAGCTACCAGGCCGCCCTGGCCGAGAGCAGCTTCCCCTCCTCAACAGCCCTGGCATGCTGAACCCTGGCTCCGCCAGCAGCCTCCTGCCCTCAGCCACGATGACGTGGGTGCCCCGTGGACCGCTGCCCAGCAACGGCAGCAGCAGCCCTCCTCGCCTCTCCCACCCCAGTACAGCCACCAGGTGCAGGTGAAGGAGGAGCCAGCAGAGGCGGAGGAAGACAGGCAGCCCGGGCCTCCCTGGGTACCCCTAACCCCAGCGCCTCGGGGCCTCCAGAAGACAGAGACCTGGAGGAGGAGCTGCCGGGAGAAGAACTGTCCTAGGGCCTGTAGGGACCGACAGGGCTGGGGTGAGACCCCTCCCTTCCAGAATCCAGGCCCCATCTCCCCTCACTCCACAGCCCCTCCCGAGCCTCAAGCAAGTCCAGACTCAGATGGGGGAGGCCCGGGCCAGCAGCTCCCAGTGTGACCTGACAAAAACACGTGGGGGCAGGGACGGTCCCCACCCCCAGGGACACAGCCCCTGGTCTGGGACCAGCAGAGGACACGGAGGTTCAGACCCCTCCTCAGACCCTCCCCACATCTGAAACCGCCTCCCCCAACCACCAGCAGCAGCAGGGCCTCCTCCCCCACAGCTCTCCCACAGGGCCCCTCAGCACCATGGAGACCCGCAGGCGGGGCTTAGCCACCCCTGTCAAACCCAGGGCCCCCTGCACCTGGCTCTGGCCGTGTTTTCTGGCCAGAGGCCCCACTCTCCTAACTCGTGCTCCCTTCCGCCTTCTTTTCCGTACTGTGAAGAAAGAACTCTCCACCCCCAGCTCCCACCCTGCGTGGCCTGGGTGGAGGAACTGAAGTTCCAGACCATCCCAGAAGAAGCAGCCCCTCTGCTGCTGGGGTGGGACTGTGTGAGCCCTGTGGGGGTCCGTGCGAGCAGGCCCACTGGCTCCAGCCCGCCCCAACTGAGACAGAACCAGGCTGAGCCAGGCCTCCACCCCACCCCCACCCCTGTTTGCTGGGGGCTCCTCCAGCCGCCCCCATAGGAAGAGGCCTGGTACCGCCTCACCCACAGAGGTCTGTGCCAGGTGTGCTTTGCAGGTGGAGCCAAGCTCCCCTGAGGCCAGAGGCGGGGCCTGGGCCGGGAGCCCAGGAGAAGGCCAGGCTGGACCCCGGCTCCACACCACATCCAGCCTTCGGGCCTCTCTGCAGTCCTCTCACCCTCCCTCAGCTCCCTTCCTCTGCAGTCGCCCTCAGCTCCCCTGCCCTGCCCGCCTCCCACCCCGCCCTCACCTGCCCCAGTTAAACGGATGACCAAGACCTTTCTTATGCCGGAAGCAAAAACCAAAACTTTTTGTTGGCTTTTCCTTTGTCGCCTCCCCAGCACCTGCCCCCAGTCTCCCACCTCGGCCCCAGGCTGGAAGCCCTCCCTCCACTTAAGTTATTGTTTTAAACCAAAGTTTACAGTGTCTGTTGGTGGCCAAGACCCTCTCTTCCACCCCTCCTCCATCCACCCCGAGGACCCTGGGGCTCAGTGGAGGCAGGCCCCTGCTCCCTCCCTCTGCTCCTGCCAGCCCGGGGGAAGGAGAAAGGAGGGGAGGAAGCGGGTTCTCACCCTCTCGGGAGTGGGCACGGGAGCCCTCCTCCCCGACCCTGGGCTGCTTCCTGGGGGCTCTCCAGACCCCTCTCTAGGACCAAGTCACTCGTTGTGCTGGGAGTGTGGATTCCAGCAAAAGAGCTGGAAAAAAGTGAGACTCTCCACAGACCCCTTGGGGGACCCCAACTCAGGCCAAGGACTGGGCGTATCGGATGTTCATAACACCCTGGCCTGGCCCCTTTACTGAGAAGACTCCTTGGATATTTCCCAAGAATCCCCCACATACACCCCTCACAAGCCACCCTCCTGAGGGCAGGGGGCCTCTGCCCCCTCCCCATGTATTCCCCACCTGTGTTCCGTTTGACCAGCACAGAAATATTAAACATCCTCTATTCACCGGGCCCTGTGTGTGTCGCCAAGATGCGGGAGGGGAGGAACATTAAAGCTGAAAGATCGCTCTGCTGGGGGAGCCTGGGCAGAGCAGCAG 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@rCer/2061/908_63_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACC + KKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKEKKKFKKKKKKKKKKKKKKKJKKKHKFKKK3KKKKKIKKKKKKKKKKKKKKKKK-KKKKKKKJKKKKKFKKKKKKKKKKKKIKKKCKCKKKKKKKK3KKKJKKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKJIKKKKKKKK*IKKKKKKKKKKHKKKKKKKKKKK=KKKK;KKK>KKIKKKIKKKKKKKKKIKKKKK/KKKDK+KKKKKKKKK7K=KK)KKJKKKK?KKKKKKKKKFKKKFKK4KKKIKCK1KJKIKKKKKKKKKJK9KKKKJKKFGKKKKKKKKKKKIKKDKKKK>IKKJKG;KEKBKKKKKIKKKKKIKKKKKKHKK@KKIKKKKK2KKKK4KKKKDKKKKKKK;K;KKKKIKKKJKKJ>E6KKKKHK@H;JKJKKIKKGJKKKKKKKKKKCKKIKJ'JIEKAKKKKKK,KJIKKKKKKKKHKJK%HJJFKIKJKJKKEKKKKKKKIKG-JKKKFKKKKK8KJKK:KKKKKKKEKKKKKKKKHJHKK?KKKKKEKKKKKKKKI=KKKKJKHKJKKJKKKKKEKKHKKKKKKKKIKHK5KKKKK0K?IKKKJDKDK3KKKHKKKKDKJIKKJHKKDKKKKKJFKKJKKKKI2JKFKKKKBKGKKKKIKJKKJKBKKKJEJKK)KKHKKKJK=KJJKKKKDKJJKK-KKKKKKJKKKK(KKKKAKKKKIJJK1KKKJKHKGKKIK?=HK4KKJKKKIKKK5JKK6KKKKKKKIK8KJ*KKKIJEKK=KKKKKKKKJKGKJAKCKKKKJKKKKKKJFJ?0KIEK4KHJK>KK(K1KIKJHK?KKFKK:KJJJKIJ%KAIKKK?KKKKKKKKKKKKKKKKGKK @rCer/2069/1860_59_CCS ATGGGTGATTTCTTGGTATCAAAATGTGCAGTTTCTACAACAGTTCAGATCACCACCACCATTTTTCTTTTTAAAAAATAAATAACTGCTCCCGTTTCAGGCAGTGCAAACCTTCATCTGCTGGAGACCAGAGGTATGAGGAGATCAGGGGATTGCGGCACCATTGGAGGCTTGCAAAGATCGGGGAGCTGGGAGGGCGAGAGAGGAGGAGGTGCAGCTTTGAGGCTGGGAACTCCCTGAGTGGGGCTGATGAATGTACATTCATTAGCACCACGGCTCACCTCCTAGGAAGACTGATGAGGAGTCCTTTGGGAGACAGTTTTGTTCTCAAGATTCACACCTTAGGAACACATTTTTATCACCTCCGAATTTTGATCCATCACCCCTCTCTCCACCTATATTTTTACAAAAACCATTCAGACTTAAATTAAGCTGAATAAACTAGCCTTTGGTAACATAGGGTGACACTGGTTTTTCAGGGATGTAACCAACTCCAGAAATACATTCTCTTGCCTGGCATGAAGCCTTTGAAACACGGGCTGCTTATTTTCAGAGTCCTGTTTTGGGACGTGTCTTGGCTACTTGTTACTTCCAGGTGGCTGCCACACGACAGGGGTCATGCCTTTCCTCCCTCCAGATGATAATGGATTTAATAGACTTAGGAAGGTTGTTTAGAATCAAAGAAGAAAAAGTCTGGCTTAAACATAGGAACTTCTGTGTGCCAGTTTGATGACAACCAAAAGCTGTCTATTTACCATTATTGCCAAACTATCAGTTGCCCATCCAGCACCAAAATCCTGTGCGTGTTTAGATTCATGTTGTCACCAAAGAGGTGCATAGATCAACAACCTGGATGACGCAGATGTTCTCCAGGGAAAACCAGATGAAGTCAAGTCTCCAGGTTAATTTTTTTAAGTCTTTTTTTAAGGCATGCAGCTACCAAGCAACAGAATAGAGTAACCTGAACGTTCTTTCTCTCCCAGGCATGGCTCACATGGTGCTTCCGGTTGAAATGTGTTTCGCCCTCCTGATGGGGGCGAGGCCACAGCCCACTACATGCAACACAGTAGAGAGCTGGGGCGAGTGTCGCCATGTCCTTGGAAGATGTCAGCTGGCCCCTTCCAGGGCAGAGTCGGGTGGGCATTGGTGCCACCTTAGGAAGGAGAGTGATGCGTGGGTCTGGCCAGGGCTCTGGAGCCAATGCCAGGCTGCCTGAGGGCAGAGGAATGCATGGCCCATGTGCATTTCTGAGTATTTTAAACTCGTCCAGCCCCTGCAGCCTTCGTGATGATGTAGCTTGCAGACAAGAGCAGGAGCAGAATTAGCCCTTTCTTCAGGCCGTCTTGCCTCAAAGGGCACACATGTTTGGCGGTTAAGATGAAACTAACCCTTATGTTCATCCTAGTCCCATGATGTACACATCTTAGCCATGCAGTGGCCTTGGGTGGCCACAGAGATTGGCTTTGAGGAGCTTGGTAGAGTCCACAGCCATGACTGAAGTCAGTGGACACCGAGGGGACAGGACTGCAGGCCACCAGGGGCCTCTGCCAGAGGGAGGCAGAGAGGATGGTGGCCGCAGGCGCTCTCCTGGCATTCTCATGGGGTGATGCCAGGCCAGGCACCTCAAAACAAGCTCAGCTGACTGGGAGATCCTTTGTACTTTTGCACAGTTCACACACACACCCACCCCAAGTGTTTTTGTTAGACACAAATGTCAGCGTTGTGATCTTGGGAAGAACTTGTCAGTGATGACGAACCATGATGCCTGTGTTTCTGAGTCTTTAAATAAAAAATGAACATG + /243.53.66,/5-40153+5350414043246.15155,51152353341,-%,+*351-.212'.2554'16642,1./(--&.140,*1(/2.-4160052*1,0-*,-5.0132551-1.315245401-01/0.045521,/465//4-132430,-0603301)33.4,*/%2312433).0533,-.34,13.22002104/352/0044554+353/./33-3035634430306501/0323360145205611/2)-542534563111+2/15.1(3&2-41400040353+454)0316010/0-,0353+5603*465253/03/5315401,4)552-4444%25225535424-244(53/105454566055443556623.,*2431$/45543*4446342--24-30*5463445230123(4.001144063160253245'0024144511124%1$*4*5615525464340224562*2246555263+2-4642-..2(.2/52./45*32123-3+456/2535+45414)1/23522-44/05/425-5-21-/3020354433,-*4543500.15-.32*(211324)4042+3.51&3#//4/-413/445426/241254)1'*(36550364665165331*56650655456432353'/.563425*05'5235654-/4/423./3/411/22*53031./*3.225)/2,4355464156436436/55365*+/463/04026334.3.4.052-234'.52/3400/3250-+3350143432*2525445.-440415/542./$2.35/01/3.44234214522//-0.2.343*543*3-102.0200'342.55462/-(434-011/22#3/1-+33623.%406315222-01.-4(0(-.3,.1-6101.0)150,051511.0)112--1/1//&36245/5+3(0421,.,42.2/0-445-246,43/,4415556)040+.13201/(-,/5,5/-/.201'23.0/551..(022231(+0-3+./-01'24.01*.-//)04546//14/6..1354,0+/36011/*12/.0./&543.0434.2536+)35160336-5536326251023+/20,1.2/0234/4145.3--23*351224/54465546-06/4555134422'05344/445,5001).-+,./2,*+12.-0154,(230#,0$0/44.2342344&53510425,21*,-*-/--/523533+4043/%+14401-35.023/6013632661.2010-/611512/+1&5445.24---,0,.4234#,-/50,&3&445544.233.22-5/2413#./12,//1000*-00,.),-'(,./+2.+-2/,,.1-&/0+2*1*.0-00+0*,/-//.//(0,122-1/,-+,/1*+'0+1.,12-0/1-2-+-,/-*-0.*,00,,1,-///,-+,+,$)*+1'+-1//)--2*..)-202,2-.11,0$(.-./).2../.../2-/,/*-/**&+,,/,11.,+/1',,&/02/-,0,*-1+'*.0-/.$/0'/(/0,/11--.120+-20.(,*,.-,/-./-.).+,12./,..----,-#//0*-..)',+*('))'%-.#,-+0(-*,+(../1'-/,00-&,0//+.*'//,+++#/),./-****$/+/+%//)/1-/+-0-.),'--&0.//,++.+%,+-.//'&./-00/..&00,./00/.%012.1/// @rCer/2072/25_2887_CCS ATGGGGGAGCACGCCCGGAACAGGCCGCCGCGCGCTGCGTCCCGGACCCGCTGCCCCCGCCGGCCCGGCCGGGTCGGGCGGCCCAGGGCGGCACCTTCCTACTTCTGCCTGGCCACAGCCCTCCCCTCACAGTTGAGCACCTGTTTGCCTGAAGTCAATTTCCAGAAGCAGGAGTCCCCAGAGCCGGCAGGGGGATGAACCGCGAGGGAGCTCCGGGAAGAGTCCGGAGGAGATGTACATTCAGCAGAAGGTCCGAGTGCTGCTCATGCTGCGGAAGATGGGATCAAACCTGACAGCCAGCGAGGAGAGTTCCTGCGCACCTATGCAGGGTGGTCAACAGCCAGCTCAGCCAGCTCCCTCCGCACTCCATTGACCAGGGTGCAGAGGACGTGGTGATGGCATTTTCCAGGTCGGAGACAGAAGACCGAAGGCAGTAGCTGCAAAGCCCTTGGAACACCCTGGATGCTGTTGAGGGCCAAGAGATCTGTGTGGCTCCTGGGCCGGCTGAGTGGCAGCAGACCCCCTTGCCCACCTCCCACTTCCCCTACCCAACCCTGCCCTGCCCCATCCCACCTCACAGCTACTCAGTGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATGATTGGCTTAAGGGATGGACTTGTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTAAATCTTGACCAACAGAAACCTTTTTTTTTATTTCTGACTCTTATTTTTTAAAAAATTTGCGCCTCGGTATCTGGCTTCCCTGGAAGCTCTCCGAGCTCTGGTGCTTTAGTTAGGTTATTTTTTAGAAATGTGAAGAGGTCTGATTGGCTGCTTAAACTGGAAAGGGACTGTGATTGGCTGGTTAATGGGAAACGGTTTTTTCTTTGATTGGCTGCAGGTGTTCTGCTGATATCAACGGCTTCCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGACTTGAAAAGAAACCAAGTGCGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGATTGGCTTTCGGTGCGTGTGTTTGGTTTCCCATTGGTTCACCCGTGACTCCTGTTGCCATGGATTCACCCCCTCTGCTGCCGGCTCTGGGCCTGAGGGTCCACCTGGAGAGTACATTTGCTTTAATGAGTGCACCTGCCTCCACCAGCAAGGTGATCCCAAGGACCCTGAGCAGCTGGAAAGTTGGGCCCCCGAGGAGCTTGGTGTCGTCTTGAACCCAACAGCCCAGAGCTAGAGGTAACCGTTAGTCGGGTTTACGTGCATTGCCTGCATGAGCTGGCAACCAGCCAGCGTCCCTTGGTGAGAAAGGGATTGCCGAGACACCGTCCAGGCCCCGCCAGCCGGGCCGGGCCAGCAGAGGCGCACTACCCAGCTCTGCCCTCTTGGCCATCCCTCTGTTTACCACTTCCTGAGGCCTCATTCTGGGGGTTCTCTTGGAAAGGGGAGGAGCTTCTCCAGTGTGAGACCCCAAAAGGCTCTGGAGGTCATCTAGCAGAGGTCTCTGCTTGGGAGCCCAGAACTCATGTAAAAGCCCCAGCTTGGCTCACAAGGCCCAGGAGACCTCCAGCTCTAACACCAACCCCTGACCTACCCCAGCCAGGCTCCCACCTGTCTGCTGCCAGCGCAATACGTCCTGGCCAGCACTGGAGTTCTCTCATTGGAGGCCCGTGCCCTCCACTCCACTGCCTTTGGAAGGGTCTCTCTCCACGTCAGCCTGGAAGGGACAGTGTCATTTGTTTATGAAGTGCCACTGGGACATCTGGCTGGGCCTTCACCAAGCAAGTCCCTTCGACCGACCCTTAAGCCAAACTCAGGCCCAGAATTGGCAAACTCAGTTCAGAATGGCAGTCCTGGAGGTGGGGGGTGAGGGCAGTCTAGTGTTCCTGCAGGAACCCTAAGTCCTCCCACCTGCCACTGCCTTCCCTGGGAGGGGGTGGTCCTCCTAGCTCCCTGGATCACTGGCAGGTGTGGGATCTGGGAGAGGGTTGGAGAAAGATGCAGTCCTCAGGAAGGGGGCGCCACCCTCCCTACACTGGTAGATGCTGAGCCCCCTAGGTGCCCAGAGCCAGGGGCACCGTCTCAGAACTAAATCTTTCCCCTTTCTTGGGGCTTGGGGCTCGGGCCATAGGGCTCCTGAGTGTCATGAAGTGCACAGGAACCAAATGACTGAGCCCTGGAGAGCCCCATGGTCAGTGGGTGGTTCACGCTGTGCTCTGGCACCATCAGCCTGTCCCAGATCGAGCTTCAGGCTAAGACCCTGTGTCCTCCACCATGCACTCACCCCTAGCCCTGGTTAGCTGACAGTCAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGACCTGAGAGCATCTTCTCAGGAGGGGCAGCGCATGTGTGCATGTGCTGTGCGAGTGAGCACACCCGTGTTCTCACTCAGATATACACGTGCACACACACGCACTCTCCAGCTCAATGGCCTGGAGGTCTGACTGAGGCCCTGGGAAAGGTGAGTTCTTTCATCTCCCTCCTCCAGGTCGTCGTGCCTGGAGTCAGGTGTCAAGGGGGCACTGCTGGCTGCCCCCTTTTGTACCTGTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTTGAGTGTGTGGTCTCTGCCCCAGCCTGTCCTTGTCACGATCACAGGCCTTGATTTTGTAACGACGACGACCCCGGCCTGTCTCATCTTCTGAAGAGGAAAAGTCAAAGTGTTGCTGTGGCTTCATATTTCAACTAAAAATATATCTGTTGGAGAAAGAAATTAACAATAAAGAATTTTCATAGG + 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@rCer/2073/25_2005_CCS ATGGGCCCCCTCCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT 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rCer/2080/0_415_CCS TATTTCTTTATTAATGTAAAAACAAGAGAACACACAAACGGAACAAAAGCTCAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGGTTAGTAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTCATTTCTGCTTTGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTATTGTAATTTGCTGCTCTCCATCATCATACAATGAATCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACACAGTTTGTGTCAATGTGGAATTAACTGCAGAACAGTGGAAAAAGAAGT + S((,+,$)$-3*14()/$.--,,)+&**-)+-2..-00106.4/&+(*21300/5./(+,,.(.020..02211.-0002--'0*//*)(32005'2/4/#./,,-0+0.42(4/50,4//2)35.43+446./2%,002/04/1/)4.'43/(%.2540//11.,-(,(5524%*00/3).2.,'/1),++14(1-(/311/*+,.+-,+22-*123223564646120)13561/3136020563--534/40206514.54350/0./.0+//.111-,8*@945<5::8;:@;B>86?=4;=9<@97=<8976<3?/<<79:7:>=>896999=;996:34:,>75;1619=6>=:;><67<8:>;3=<;7=;>:=3;97=81,,057==7>=1<<=>=01%74457369; @rCer/2081/25_2079_CCS ATGGGAGTGCCAAGATGGCGAGGCCAAAGAGGTGAGGAGCCGGCAGCGGGGCGGCTGTAACTGAGAGGAAGGCTGCAGAGTGGCGACGTCTACGCCGTAGGTTGGAGGCTGTGGGGGTGGCCGGGCGCCAGCTCCCAGGCCGCAGAGAGTGACCTGCGGTGGAGTTCCCTCCTCGCTGTTGGAGAACGGAGGGAGAAGGTTGCTGGCCGGGTGAAAGTGCCTCCCTCTGCTTGGCGGGCTGAGGGCCCGAAGTCTAGGACGTCCGTAGTCACCCCGGCCTCTGTGAAGCCCCAGGTCTAGAGACATGACCCGAGAGTGCCATCGCCGGTCCGGGGCCTGGGGCTCCGCTGAGTGGATCGGTGCTGGCAGAGGCGGCAGTAGTGTTGCAGTGGTGCTGAGCATCCATGCAACTGTATGGGACCGATACTCGTGGTGCGCCGTGCCCTCGCAGTGCAGGCCTTCTACGTCCAATACAAGTGGGACCGGCTGCTACAGCAGGGAAGCGCCGTCTTCCAGTTCCGAATGTCCGCAAACAGTGGCCTACTGCCCGCCTCCATGGTCATGCCTTTACTTGGACTAGTCATGAAGGAACGGTGCCAGGCTGCTGGGAACCCGTTCTTTGAGCGTTTTGGCATTGTGGTGGCAGCCACTGGCATGGCAGTGGCCCTCTTCTCATCAGTGTTGGCGCTCGGTATCACTCGCCCAGTGCCAACCAACACTTGTGTCATCTTGGGCTTGGCTGGAGGTGTTATCATTTATATCATGAAGCACTCGCTGAGCGTGGGGAGGTGATCGAAGTCCTGGAAGTCCTGCTGATCTTCGTTTATCTCAACATGATCCTGCTGTACCTGCTGCCCCGCTGCTTCACCCCTGGTGAGGCACTGCTGGTATTGGGTGGCATTAGCTTTGTCCTCAACCAGCTCATCAAGCGCTCTCTGACACTGGTGGAAAGTCAGGGGACCCAGTGGACTTCTTCCTGCTGGTGGTGGTAGTAGGGATGGTACTCATGGCATCTTCTTCAGCACTCTCTTTTGTTTTCATGGACTCAGCACCTGGGCCTCCTCCATCTTCTTCCACCTCATGACCTGTGTGCTGAGCCTTGGTGTGGTCCTACCCTGGCTGCACCGGCTCATCCGCAGGAACCCCTGCTCTGGCTTCTGCAGTTCCTTTTCCAGACAGACACCCGTATCTACCTCCTAGCCTATTGGTCTCTGCTAGCCACCTTGGCCTGCCTGGTGGTGCTGTACCAGAATGCCAAGCGGTCATCTTCCGAGTCCAAGAAGCACCAGGCCCCCACCATCGCCCGAAAGTATTTCCACCTCATTGTGGTAGCCACCTACATCCCAGGTATCATCTTTGACCGGCCACTGCTCTATGTAGCTGCCACTGTATGTCTGGCGGTCTTCATCTTCCTGGAGTATGTGCGCTACTTCCGCATCAAGCCTTGGTCACACTCTACGGAGCCTCCTGTCCCTTTTTCTGGATGAACGAGACAGTGGACCACTCATTCTGACACACATCTATCTGCTCCTGGGCATGTCTCTTCCCATCTGGCTGATCCCCAGACCTGCACACAGAAGGGTAGCCTGGGGGAGCCAGGCCCTCGTCCCTATGCTGGTGTCCTGGCTGTGGTGTGGTGATACTGTGGCCTCCATCTTTGGTAGCACCATGGGGGAGATCCGCTGGCCTGGAACCAAAAAGACTTTTGAGGGGACCATGACATCTATATTTGCGCAGATCATTTCTGTAGCTCTGATCTTAATCTTTGACAGTGGAGTGGACCTAAACTACAGTTACGCTTGGATTTTGGGGTCCATCAGCACTGTGTCCTCCTGGAAGCATACACTACACAGATAGACAATCTCCTTCTGCCTCTCTACTCCTGATATTGCTGATGGCCTAGCTGTTACAGTGCAGCAGCAGTGACAGAGGAAACAGACATGGGAGGCGAACAGTCCCACAGCAGACAGCTACTTGGGCATGAAGAGCCACGGTGTGAAAAGCAGATTTGATTTTTCAGTTGATTCAGATTTAAAATAAAATCAAAGCTCTCC + GJ,G;1DJI3I1JF@E?IJHH8?*J2GKAK0HK@IBHF@+I)J@HDF'KKIJ7FJDKEAK.ADIGJ5HEKAEFHHEGK?GI=KIJJKKJJCKGG>KIJJBJIJ4HK;KGI@FCIIFE:>%7AE/@/BH@IKD@@=ADA@EEIE2HEFJFE8G837F67;FJCCJ;@*8BA?FFEIC&79E=FJBFAJJJKDK>J(87=GEHKG?D5IB5@IIGGKIGK1DC(HDGHJ>(GI7DI??IHFHF=@KIKHJDHFD>?F?;-96DAI?HHIHJJJEGG;GKEE>HFIJHJHBJIEI>K'FDEFJI99G):CJDCJJ6@>%D(CGG@HB'IHIJDGKKEFKH;GDKJKK4@F@BF)JK=CI=EJ>HE=K=JGB1$F9JKJDGGD>JCBECCHG@@>ABD>JFH7HHI*E?D@=:AG/33?@@8;DGA$+DBBDEGFJFA:<7F,HHKKHCCGB4EAJKGJCEIE/KGE@J:B:B6DC@KC=EG'F=:IBED;DCHBAKCHJI8I,FF;DHDABAJ>89HHIJH4B6IEHGGEDKJF)BE@2:@01;F><<8=*GFDB0E?HBA@G5GHJDHF@AK6IJ7KA<:?J@B4>FE:DBAHHAE?@FEE@BCDE1=FFDGF8?I==AD8A62:=87J@>?HBIKAGGJI>ECAFC;FHKKIG=GAGHJD(FCE>;B@?FG?IEJJHBHFEJ7BFB>E?=<,@EHH@I,G=EFAGFI5KB>'>BEF'>H>C,JEEIBBHK3B;@:J=5ICC@FAFH3@AEF4HGA>E;HGHFIHHHBEC;B@;CCCBADFDCFG1G@0;-CF;>?A(DHA<-@FFHJ@JAAHKI6GF8AB-IEA?EF1J:0A7@@B=?8GAC=>77CAGE=,D@J>A599+4?+=@C;@DA;JHAG@B,DBJAHKG:?FKCE/B3?'GF>6BGAB61FA9C=EFIJ@IBGF@>C=@G7+::;43=:;/DFH;:>>?:&89C@*25-67=D=A(C?=BF.91CF6E>CCCG<47@HB=&G>J/CIHBI=>?@?AEECFJKC7HHAGH=H?A@>45;<5GIHEFI@DJJJFA;F@05GB>EEC9CBGDADFDDEBIAHEAD/EB3AE@CEEFA@<9C)EEC@HD;DD@?F@%;:9>@?(<@@>?8@E6>9?(C794==FE$<=@:;53CD'D%6AB9?;'A=999CD:=B>CFFJF>@EDBD-<:>;'=7?49?@>@?065@6?>>.C1EFA8AA5B@AE=ECD<=AC6AC:=CA<>?>AC0F@>7E?@BB@@4HD4AE@>;<9:*E@4<@&==IC2EC>DHC=>?=>E>BD<><;;<=CAAC7ACCE=C@@ABB>%5:3=A68:FEA:8C4BA?E=EA56'62<#8;==?6=A5%8@6??=?C2?AB@3:?>=AA3@G@E/?AC=>1@41>DE:%>@C=?3ABCC?A6;C @rCer/2083/25_2144_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + KK:KKKKKKKKKJKKKKKKKKKKKKKKKKKJKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK*KKKKKEKKKKEKKKKKKKKKKKKKIKJKKKKJKKKKKKJKKKKKIKKKIKJKKKKKKKKKKJKHKK9KKKKIKKKKKKKKK@IKKKKKKGKKKKKBKKK7KKKKKKKICKKKKKJKKKKKKKKKKJKKKHKKKKKKKKKKKKKKK(KKKKKKKKKJKKKKK$KKKJKKIK0KKKKKHKKHKK9KK0KKFKKKKKKKK7KKKKKKKKKJKKKKKJK@KKKKKKKKKKKKK:KKKIKKKKKKKKKKKKKKKKKKK6KKKKKKKKKKIKKKJK;KKKKKKKKK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKK9KKKKKKKKEK8KKKKKKKKKKKJKKKKKKFKK?KIKKJJKKKKKKKAKKKKKKIKKKKKKKKIKKK$KKKJKKKKKKKK@KKKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKDKKKKKJKKKK:KAKJKKKKKKK?KJKKKKEKKEKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKHKKKEKIKKKHKKKKKKKKK@KKKKKKKCKKK>KKKKKKJK @rCer/2086/24_1745_CCS ATGGGGAGCTGGCAGGCGGGCAGCTGCGGCGGCGGGCAGCGGACGGCGCACTGGCGGGCGCCTCCACCTTGCTCCTCCCTGGCTGCCGGCTTCCTTTTGTCTTTCTGGCGGCGATGAGCGCAGGGCCGCGCAGCAGCTGCGGGCGCACAGAGGCCCGCGCTCCTAGTCACTCCTCCCGCCTCGGCGCGCTCGTTCCGGGCAGCGGCCCGGCCGGCTGCGGCCGCCGCCGGCGCCGAACTTGGACTCGGAAGCCGGCAGACCGCGTCCTGAGCCGGAGCAGGGGCATGGTCTAGCGGCCCAGTCAGGACACACTCCCCGGAGGTTCTGACCCACTCCCTCTCGGACTCCTCCTGGTCTCTGGTGTAGTCGCCGCCGCCAGCCGCCATGGGCAAGCAGAACAGCAAGCTGCGGCCCGAGTGCTGCAGGACTGCGGGAGAACACGGAGTTCACCGACCACGAGCTGCAGGAGTGGTACAAGGCTTCCTCAAGGACTGCCCACCGGCCACCTGACCGTGGACGAGTTCAAGAAGATCTACGCCAACTTCTTCCCTACGGCGACGCTTCCAAGTTCGCCGAGCACGTCTTCCGCACCTTCGACACCAACGGCGACGGCACCATCGACTTCCGGGAGTTCATCATTGCGCTGAGCGTGACCTCGCGGGCAAGCTGGAGCAGAAGCTCAAGTGGCCTTCAGCATGTACGACCTGGACGGCAACGGCTACATCAGCCGCAGCGAGATGCTGGAGATCGTGCAGGCCATCTACAAGATGGTGTCGTCTGTGATGAAGATGCCGGAGGACGAGTCCACCCAGAGAAGCGCACGGACAAGATCTTCAGGCAGATGGACACCAACAACGATGGCAAACTGTCCTTGGAAGAATTCATCAAAGGTGCCAAGAGCGACCCTCCATCGTCCGCTGCTGCAGTGCGACCCAGCAGTGCCAGTCAGTTCTGAGCGAGCGGCCCTGGACAGTTGCAGAGAAACACAGGCTTGTCGTGCCGTTTAAGCTTTGCTTGCAAGAGTGGATGCCCCGCAATCGTTCCTGCTCTCCCGGGCCCCAGGCCTGGGGCATGCGTCGCACCTGCCCGGCCGGCGGCTGCGCCTCCTCTCCGCCTGACAATGCGACATTCCTCCCCTCACGCCGGCCCGGTCCCTTCCAGGGCAACTCCCAGGGATGTGATGACATGCAGGGTTCAAGTGTTCTTGGTTCCAGCACCTCCGGCTCATGGGGAGCCAGAGGTCCATGCCGAGGAGACCAGGCAGGACCTCCGAGGCTGCGCCCCGCCGGCCCATGCATTTTGTGATCCCAAGTGACTCTGTGGGGAGGGTGGGGCGAGGCGTCAGGAGGGTAGACGGGAGCCCCTCCCGTGCATGGCTGCCCTCCGTTCATTTTCTCCACCACAGCCGCTTGCACGTATAGATACTGTGGTCCCTTTCTTTTAATATATAAATTATGTATGGTGAAGTGGAGTGTAATGTGTAGGTCCCGTATTTAATGCCTCTGACTGCCTTTGAAGCGCAGCCCCTGTGGCCCGCAGTCCCTGAGCCTGGCTGTTGTGTGGTATTTATGCTCTCTTTGTCTGCCTGTTTCTAAGGAAATGCATGTGTGCCCTGAGCCGTGACGATCCTCCTGTCCGTGTCGCGAGCACAGGCATTTGTGTCTGGTCTGTCCTCCTGTTGATTGGTCTGGCATTTCCGGTATTAAAATGATACAATAAAT + EK)KKKIJ@J1KHJ;KK2KKKKFBJJJHKKFKG'IJKGGKGKAJ+K?JCFJIHKK2KK;K1KK:KK3KKKKJK4KK,KKK2K>FGHKCKICK.KDKKKIGKDKKKK/KKKKKKGKKKKKJKK;KK@?&FGKK?GJJKJKK5KKJK@KKKJKBK8KKKKKKK?IKHKKICJIEKJG?KBHKKK=KKKJKJKKGDKE=@J@KKKGJJ;K%KFFF%DIJJKKK8D8%JIK'AK6K;KJBKJKH:KIJFKKKAGE@KHJKGBKKIKDKJJK>KKKKJ2BGKIIK@BKGKJKH:G=I>JJKIGKEKKFKKIIKKGHJ?KKKKJIFKKCK2KKKDIKJHGKJKJIKKJJJHKKKKIJ&GGJCK7KKJ:JEIKEJADIGGDKIDKJ5KHE(K(=CKHJJKKIIKJIHC)JKJKFF=JK?IBGK;JKKKKKKJ;KKKJKJKDKHKEIIDIBGGHJKJKKK;D6KKJJJFGJKJDK5HKEH+GGAKJKIKJJIIFI>JKKKJ9KJ@JAKKEKHJKJHIKKKK4A7EJIGKJKIKJKKFGKJJ+KK;D;;4KGBKKHHKCJDKKJKIBKKI2KJFKKKKI3KKKDIKKJJK(KKKKKFKJKJ=JCKIKHI4H6GJ/KJ*KKKK@K@KK)KKJJHIIIKJAK?D=KJ;2KK<@)KIKDCJKIJKK8KJ+IF%GFKK?JJGG%HKGHKKJJKKK7KI%KKKKJIBG(KAJKKK*KKKK6&JFEJ7KJFJH:G2KJJ7IF>J9KJ;KKJ,KJ1FG*KGF>KKHKKK6KI''?KBK*KKKJIKJ,KKKJKJKK@KKFKFJEJICKKKJ(IIJI)IKI'KKJIJK2JKKKKJCKG9JKIKIKA&IKB:7KKKK1IJIIKKJI2KIJ@1ID82JJGKKJAKJKJJ@GKCKEJIKJKKKCKJKKKIFIHKJJKKKJJG&HI%KKHKKK?JKKKKDIKIA?HK?IKEIJIJKCCAIKIGIE4HJJ?KHKKKIIKEKHKKKKKKH8KKKIKKJKHJ3KHKKDIJJJFJJIB+KKKKKKCKJHKJKIHG%KKCKKKJ1KKKKKKKKKIFEJBI>K8F9GKIIJIFIFKJIJIK;FK4K>DCKKKFKIK>?K$HEG>KKCKKKG @rCer/2087/1793_55_CCS CACAAATCCAAAGGAATTCCAGAGTTTGGTTACCATCTTTAGAAATGTAGATATGCTAAGTGAATTAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATAAAGTGAAGTTTCTGACCTGGACAGCCTATGTCTTTTGTGTTAGAGTCCACTTTGAACCAACGACACTTACCAACTCAGTCCTGACAAAAACCTACAAGATGAAATCAGAACCAGATAGGCTGATCCTTTTCTTTGAAGGTCCTGAGATTGTGGACTGTGACGGGTGTACCATTGACTGGAAGAAAGGAAAGAATGTTACTGTCAAAACATCAAGAAAAGCAGAAGCATAAGGGTCGAGGCACTGTTAGAACAATTACGAACAAGTACCAATGAGTCCTTTTTCAACTTCTTCATCACTGAAGCATCCGGGATGGAGAATCACTGGATGAAGATTCTGAATTCACATTAGCCTCTGATTTTGAAATGGACACTTTTTCCGTGAGCGATAGTCCGCGGGCTGTGCTGTACTTCACTGGGAGGCATAGAGGATGATGACAATTTTGAAGAAGGTGAAGAAGGAGAAGAGGAGAATTAGAAGGTGACGAGGAGGAGAAGACGAGGATGATGCAGAAATTAACCCAAGAAGGAACCAGCCAGCCGGCGGAATGCAGCAGCAGTAGGAGCGGAGGCGGTGCCTGCAGACGACTGTCGGACTCCAGGCCTGTGGGCGGGCCCCGTCCTTGCCGCAGCACAATCCCGTCGACAGAGCTACTCCATCTAACTCGTTTTCAAGTGCATGATTTTCACTTTCACTTTTCCTTTTCCTTATTATTTTGCTTAACTTGTACAGTGGCAACTGAAATGCATTTCAGAATAGGAGTTTCGTCCAGCACCCTCTGCAGCCTTGGTGCTGTAGCTCGGACTGCCTGGCCTGTGGGAGGCCCATAGATCACATCGGGTGGGGGTCACTTGGCAAAAGGCCGAGGTCTGATGTGGTTCCAGGATCTAGAACCTCTCCGCCTCCTGCAGTTGGACTGATTCTTCCCTTCATTCGAAGAACCCACTGCTGTTCCAGCTGCTAATCTGCCGATGTGCAGCCTGCGTCACTGTTACATGCTAATCATCTCAGAAGGGCGTGTAGAGTAGCTGTTTCTCTTAGATGTTGCTTCTTGATTTTCTTTTTTAAGGGTGGTCAGGTTGTGACACACAGCCAGCAAGAGCTGCTGCGGTCACCTCAATTTATTATCCCTTCTTGCCTGTGAGGACTGCGGCCTTTCGCTGTCACTCGTCCTTACCATTTCTGAACCACCTTGGTGACCTGAGCGGAAGAGGTGCACTCCTAGCAGGAGCAAGGCCTCTGCGAAGAAACGCTGCTCCTTGCACCAGGGCTGAAGACGCGAGCCGTCTCGTGACGCAGGCGCGCCCTGCGCGGAGCCGGGCTTCGGCGTCTTCTCCAGTGAGGGCTGGCTGGAAGTCTGCGTTTCAGTTGAGCGTATGAGCGTCAAGTCCTGCTTTCTCAGTAGCCCATTGCTGGCCCACATTCATCCTGTCTGAAGGTCTGGTTGGTGTGACCGGTTGCGGCTGGTGGTGGATTCCAGTGGGGACGCACTCTCCAGCAGCCTGGGATGGCGTGTCCACACCGACCAGGCTGTGGAGAGTGCTCAGCCTAACCTTAGAACACATTGTAACTGAATACAGTGTTTCAATTGTACAGAATAGTTAGAATATTCTATTAAGTTGTGAAAC + !!(.2)+2#(0,807,7*8260..3##;6>&/5+=85?>,DA==-:EB:97;+-:C1E=:=$D&@)?C*D2:?2B-AA8811@DDG5>-@?;*:DA036B?BF>AD;AD=(8G6=>:D1?;4*;B9=9'4=-61/AA<@833::>@A-;53B(9?29&28ACA@*<7/B%+*>@?$56@$63,B.4957A8>/>ADBDCED(@*6?FF8-=D?9A)D876?=30%9>C<7:$/G7/&&E+4G9=,BG=E@D@3C0=BGEF7.@<5EDFG()7:=G5-J6E@87H=D;BDI0B*HE'AG?>E5>GGE1AG@HD>B@3@>)FD)B;-F;)9@HAFG1=>E5AHAH1@@AC)?@28<>;(E?HDJCIJ:IJJI/II@FHEIH@F)E*BGF:>#@98EF3JJ3DDFCCAK5B8C#I@C=HCGD'<=4HB@-?H597%5AH?74)DE,FEF'FI;>H2G'=JH0@K-D'CDI7B>H/*%=BH+>IE=I01*?;9;=C?'DHG@D'H.@1GJH5@>J@IG9$<6A8@BHF)=9AI:CKCJ4,14GF)HJG/,@1#%FJ9F-JE:EFJDC?IA0=AB%@>AJC>?JIII$0AAF5HCDEE:G?AB==@'EF<@>HIB?;:@?@)BCGFG=GC6@BC)D?GGF8?$I.16$@:><)>AA,G.A?6>A?E,0>C/)G-58=@>+;CB8DA(B;<8#4:B9;6@G32;BE(075-EE=8@A=FCEE:G56%:53>DA<>B>(64;5$5@(9@/F*650B<0)B(,?)30:A3589/7C@A?,,;CCD%9@B=>'?&B>=;%/*60A?A.82-)?D6D4;.82%<)29-0A/;.776@2*?3:>>;??;2<'9&=C98;$(,8A@:C=);9:C-=D1C%1>;@B:>D7@A:9?+1%7<<-'*+;?A6<,19B6<>:,B>9A@-&*9:;//5)>61&%0-5(-2:<)>$62=D9FDEBB>=B@??A++<9;<='@7DB747);&,3-')9'=ACA2=,0>+@@)?@6@BB5A>>AEC'E6=@*A@C2B?4CB;B>==*>*7=+><,>A%6==?E=41+;5%$(1==>;@2@AAB/A-@322:?;(42A>7)/57?=74>7;84'9,./7@(&0AA6A@A=-73..1:?%)9@AD74ECB;364%01*'98$)-@=?;F9FE6:D+=:/9.-::3<5?8-.59:5=$+5;1B>:&55+2%=@@=50%9:83%<>DDC;(,509?9/9=2>=B33<&-?>=:639AB(=A4?;=:';<$/'8<31:8:37:@A9?C2:)/+,<#1)55346:67>6B;C:@C?5.*;/,A@C<>7>6-8*?:?108$+A/>G=6<0:A;B7D48=)'9-7(C2@@>@C01<<.;/8=='?:15(8(?B=:@.;?D?5;;C50-B*<:E@*@*7A1=:4BB*A @rCer/2088/735_88_CCS ATGAGCTAGGCACGGCAGACAGATCGTCCCTGCGGATTGCCAACCTATGAGGCAAGTTTCATTCAGCGAGGCCTAGCATCTGGTTAACATGAGGCTTGAAGCCCCCAGCGCGCAAGTACCTTGCTATTGGCACGTGGAGCATCGCATGGTGGGCAGCAGCAATCGTTCTATATCATATGCAACAATGTCCTACTGCAGATCATATCTTCCATACCAAGTCTTGCCATGCCTTATCTCGTAGCCACTTTTGCTTTGTAGTATGGCCAGAGGTCACCAAAATATCTTATGCAGGAGAGATGCCTTTCACCTGGCCCAACCTGTTCCTTTTCATCTTCTCCCTCCCCCTCTCTAAATTGCTGCACATGGTGCGACACCATAGGAAGGGGAGCGATAGAGAGCTCCAACATGCTAGAGACGGCCAGAAGACTTGCTAGATGGTCAGAGCACGGCAAATGGCTGGGGTCTCCGCCTACCTTGCCAGCTTCCCACATTTTCCACATGAATGGCTGCGTAGCCTTACTCCTTGGGCTCTCCTTCTGACCTCTAGCACTGTTTACCTGGCCAGAGAGTCAGTACAGACGCCTGAGATCATGCTCTATTAGAAATTACATATCCATCAGCACTATAAATTGGTAGAAAAACATAAC + %"$*-$*).)-&')(((&--,"*.'*$%#$-.,.+%.$/&))""%-(*+',+.*#&-%%&-.#'&%&*",(%',(.#,%$#.++*.,'-/,%.)./*/)#($)#%'+#","+*&#+--%",#-'-%##.)--#.$&)*,%-#*&#...,..,'-*/.,/,$-///#(-.&..#,(.$,/%+-+-$/."+--%&'-"'-#.*#%%.,($')%")),*&.$-)(#%&&#&%-$&-.--(/$+#,(,+&(+*.$-$(.-,#&'..*)-)'"*#####&(%*&*'&+-"#,/(-.)(--.$+/()*)+*,(#(-%$(#%(,,,,.)',#%##-*.+.*,)*+&&((%))&+&+-""..(.-./%&)''-*&.#)'-$",,...)&$-%')+&".+.,.%'+-+)',$&#,.&--*-**"!,%)-./.*/."-$/&-*,-$)%%-,%+,*)).*#""++/+...('#.%-*'"(%-$*,&,/*&%/.$**&,--,.#&$%+$,,./&#.&+"#,&)**&##-&"%.++.(-,$-'%,)"+)+(.%&".#+#.)"++..%)"'',-%#(%++$%,-"./&.(-/,"*&#'.#"-/-)/-+$,#*.("."$)%#+(+'$#-+'/*/.%*$"..-'.-#/*-"-#&%.+,(.-+$ @rCer/2089/25_1789_CCS ATGGGGGACAGTAGGTGTGGGAGCCGGAGCGCATAGACTTGCAGACTCGCCGGCTTCACACTCACTCGGTGTCTGCTGCACCGCGCTTCTTCTCCTAGGCACGAGACCCAGCGGCTAGAAATTCACCATGTCTATTTCAAGGTCCATGCCAGGGAATCTTTGACTCTCGTGGGATCCCACTGTTGAGGTTGATCTCTTCACCTCAAAAGGTCTCTTCAGAGCTGCTGTGCCCAGTGGTGCTTCAACTGGTATCTATGAGGCCCTAGAACTCCGACAATGATAAGACTCGCTATATGGGGAAGGGTGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGGCCTGCCCTGGTTAGCAAGAAACTGAACGTCACAGAACAAGAGAAGATGACAAACTGATGATCGAGATGGACGGAACAGAAAATAAATCTAAGTTTGGTGCGAACGCCATTCTGGGGTGTCCCTCGCCGTCTGCAAAGCTGGTGCTGTTGAGAAGGGGGTCCCCCTGTACCGCCACATCGCTGACTTGGCTGGCAACTCTGAAGTCATCCTGCCAGTCCGGCTTTCAATGTCATCAATGGCGGTTCTCATGCGGCAACAAGCTGGCCATGCAGGAGTTCATGATCCTCCAGTCGGTGCAGCAAACTTCAGGGAAGCCATGCGCATTGGAGCGGAGGTTTACCACAACCTGAAGAATGTCATCAAGGAGAAATACGGGAAAGATGCCACCAATGTGGGGGATGAAGGCGGGTTTGCTCCCAATATCCTGGAGAATAAAGAAGGCCTGGAGCTGCTGAAGACTGCCATTGGAAAGCTGGCTACACTGATAAGGTGGTCATTGGCATGGACGTAGCAGCCTCCGAGTTCTTCAGGTCTGGGAAGTATGACCTGGACTTCAAGTCTCCGATGACCCCAGCAGGTACATCTCACCTGATCAGCTGGCTGACCTGTACAAGTCTTCATCAAGGACTACCCAGTGGTGTCTATCGAAGATCCCTTTGACCAGGATGACTGGGGAGCTTGGCAGAAGTTCACGGCCAGTGCAGGAATCCAGGTAGTCGGGGATGATCTCACAGTGACCACCCAAAGAGGATTGCCAAGGCCGTGAACGAGAAGTCCTGCAACTGCCTCCTGCTCAAAGTCAACCAGATTGGCTCCGTGACCGAGTCGCTTCAGGCGTGCAAGTTGGCCAGGCCAATGGTTGGGCGTCATGGTGTCTCATCGTTCTGGGAGACTGAAGATACCTTCATTGCTGACCTGGTTGTGGGGCTGTGCACTGGGCAGATCAAGACTGGTGCCCCTTGCCGATCTGAGCGCTTGGCCAAGTACAACCAGCTCCTCAGAATTGAAGAGGAGCTGGGCAGCAAGGCTAAGTTTGCCGGCAGGAACTTCAGAAACCCCCTGGCAAGTAAGCTGTGGGCAGGCAAGCCCTTCGGTCACCTGTTGGCTAAATAGACCCCTCCCCTTGTGTCAGCTCGGGCAGCTTGAGGCCCCGACCAACGCTTGCAGGGGTCCTGCTAGTTAGCGCCCCTCACCCGCCGCCGTGGAGTCCGTGCCGCTTCCTTAGAACTTCTACAGAACCGAGCTCCCGGAGCCCTGTTTGGCAGCTCTAGCTTTGCCGTCGTGTAATTGGCCAAATCACTGTTTTTCTCGCCTTACTTCCACCAAGTGTCTGGAGTCATGTGAGCCTCGTGTCATCTCCGGGTGGCCACAGGCAAGATGCCTGGTGGTTTTGTGCTTAAAATAAAAGCCTCAGTGACCAT + 77'=<<87>;7993654.&6=58092:3(337;1:33+0396:>4%'5:/7=?7.<,28419<4$.1:8&77+9939;:.%0/#8>>=>99)70;:;96%09;8:9/<;6685;>5873;<188<4<9>;<9334<(1331>9>;42)9494*9($/0:96+37:?>8;?9?5>>9=5;?>:=?:94?=<9=:=287249>5':.27:8=7<;;==.;<;+<4>718;;92/>:??210:?<,56);A6<2.@>-=(6::=:;6:86:4@:@0A.<75<;=AA7@C6?A3>=B@?79<=3BCDACB4D?&6:@<8B@40@4DD7B7E@@0?CGB@DB@CDCABA3A4>:2C42%=BB;ECB?C<>??2@;:;EG7G>G(;7GCBE&A=4=1A>BB@9C99GH89BAFB=C?F1BF4E77,CDA::;)DGBFD>DE:GFIE3G@@A?EGGII:C&@6B.@J0FG>F6/BE@BDE=>0B<*?EDHDDD75I9DG?G>BI:J/EFD(B@6DGHDA:CC-C>,EHD=)F>3HE@GEHH>69A8@AC:BC2;A6B@IEBDJIHFG8FGB?DA.F5FFEE@?CI@IE@;BA@>>6DI+EFDF@02CB,95C8B;+BDGCCCF:D2E:$;;9HFD8;%BE;IC?=BCA:?AB18F(=/JGDI>C?=FF?C7F>AED:6D713*G,6@DCB>IGBEFFG?BEG>H0C<1F>C<9C2B>9?;AA@B?7)>?>E:4BEIIGIF@@@?DB,CE1F?;FI?@EI=8EE:?BG?IB48+%?B@=AD$@A>>07@07AFDF77/:G6CBF?AG8>C04H?=FD-I=7?>AA@?8'<@HD:C?D8E=FBA<>;99E3E4>D-FB-B@CD3A=?E?EE?I8B>AG2F@@@2H7&?9F0?AB5JC<@GA,A=6;B:@D8B?AD>552?())22I)=CH7AF>JD>F7CCDCHEAD6;9%D@DI@FA@EIF>(F@?<7<<;.@/>A15>=5FHC-<4E?<*?*C@<C6)6??+6?:699JED'@+HCF@8:IBC=8;AEB;=:C@C@=*DGFF9B+GC=)EB:@<EC,4@5BA.82@DC1B1ABB.6'FA29>79DA5>2??DI?3F19D.ED>:>HC>D>DE=B7A1<@G6JF8H<2DI,D?E?@EFA@B?DB94C2BB.F(A<@F?:3BB1EE+,)<9:/?3FB:?AFE5H>>@@>FD1E=+>+HHD@DGD'=4GGB:$GDCFGEGED8DED%BDC @rCer/2091/2330_59_CCS ATGGGGGCGCTGTGGTCGCCGTGCGGGTCTCGTTTGGAGGTCTCACTGGAAGGTACCCTGCGGTCACAGAGACGGCATCCCGGAGACGATGGCGGAGGGAGATAATCGCAGCACCAACTTGCTGGCTGCAGAGACTGCGAGTCTGGAAGAACAGCTGCAAGGATGGGGAGAAGTGATGCTGATGGCTGATAAAGTCCTCCGATGGGAAAGAGCCTGGTTTCCACCTGCCATCATGGGTGTGGTTTCTTTGGTGTTTCTGATTATCTACTATCTAGATCCATCTGTTCTGTCCGGCGTTTCCTGTTTTGTTATGTTTTTGTGCTTGGCTGACTACCTTGTTCCCATTCTAGCGCCTAGAATTTTTGGCTCCAATAAATGGACCACTGAACAACAGCAAAGATTCCATGAAATTTGCAGCAATCTAGTAAAAACTCGACGCAGAGCTGTGGGTTGGTGGAAACGCCTCTTCACGCTAAAGGAAGAAAAACCTAAGATGTACTTCATGACCATGATCGTTTCTCTTGCTGCGGTTGCTTGGGTGGGACAACAAGTCCACAACCTGCTTCTCACCTACCTGATAGTGACTTCCTTGCTATTGCTTCCTGGACTAAACCAGCATGGAATCATTTCGAAGTACATTGGAATGGCCAAGAGGGAGATAAACAAACTTCTCAAACAAAAAGAAAAGAAAAATGAATGATTCATCTGCTTTAATCAGGGTGATTAGTGGCGCACCCATTGCTCCGGGAATGGTTTCTGCTGTACTATCTGGATACTAAAATGTTACGGAAGTAGCTCTTTGCTCTCCCTCACTCTGCACTTAGTTGATAGAAATTCAGACTCCCCAAGTAAGGCTTTGTGCAGTGTCTTCGTGTTGCGTATAGTTGAGTGCATTCTTAGCAGTTGGCTTCATGGACAACTCATTAGTGTGTATAATTTGTTTTTGATTTTTCTTACCCAGTGTTAATTGAATTCTTGCTTTTAGACAACTTCCTTTTGTAGTGGTGAACCTTGCCCTTTAGTACAGTTCAAGTGAATCTGGATAATTGTTCATCTTTGCTTTAGCTTAGATACCATGTAGTGGTCTGTGTCTACAGGAAGCTGGTTCTGTCTGCTTCCACAGTCTGCTTAGAAAACTGTCTGACTTCATGAATATAGAGACCAAGTTTACCACTTCTGATGAAGAGACCAATTAAGATTCATTCCTCATTCTGTTTCTTTCCGGTGGGAGAAGAGTCCCCATGAAATAAAATGAAACTGATTCCATGTGCTAGTACGTGTAGGCTTCTCCCTTCTGCAAAGCTTAGCAATTTGTAGGAAGCTTTGATCTTTTTGTCCAAAAAAAGGAATGTCTGACAGGCTTAAGCTTTTGTCCCCTTGCACTTAGACTCGAAGTTAGTAAATCCTTAAGGGCTTTTGAATAGCAGACTTCCACAAGATTACATTTAGGATTTCTAGCATACTTTTAATTTCAGATTTTCAGCTGACTTTAGCTATAGTATACAGTAGGTTAAGACTCATGTCTATGATTTTTACTCTAAGACCAGCAAAAGGACAGCAGTCTAATATGTTTAGTTAAGATTCATTTCAGTAGAAGATAATCTTATCTAATTTTTGAGACCAGAATAAGCCTTTTAAGGTAAACCTTAAAATTCTCATTTTATGGTAATACTGGCCATTTTAGTCCCCTAGGTTTGACATGGGAGATAGTGACTACACTGGTGTCTGACTTTTTTCCTAGAGATTTCTCCCTGAAAAATACAAGGGCTGTTGGTGAGAGCAGACTTGAGGTGATGATAGTTGGCCTGTGGTCTACAAAGATTTCGTAACTCCTTGGAAAGCTTCTTCTTATCATTCTTAACTTGTTGGTAGCTAGAAATTTAGAGTAGTTGAAATCTGTAGGAATGAACTTCTGAGGGCCAAAAAATGTGACTGACTTGGGAACAATTCTTAAACTGATTAGCTGTAATATAGTTTTGTGAATTTATTGCACTGATGTTGTACCTTGTGGTATATCTGTCCCTATTAAATAAGTGTTTTTTCCTCTTTAATATTGCTGTAAACAGTGGTGCCCATTGTAGCATATGTTTTTTTTTTTTTTTAATATTTCATAAGAAAACTACCTTAATTTTACCTTACTTTCATTGTAAATAAGCCTATCTTCCTATCTGGATTTTCTTTGTGTATACATGTTCTACTGATTAACTACTTTTGCAGTTTTAATCCTGTATTATTCTACCTTGTGTAAAATGGGAAAAAATAAAAAAAGCT + IKKKKK8KKJIKEKHKKKKKKKKKKK;JKKKKKKEKJFKKHGKKKKIKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKJJKKKKKKBKKHJKKJJKKKKJKKKKKKFHKIKKKKIKKKKKKKKKKKJJKKKKKKKKKKKKIKJJKAKJKKKKKKKKKJKKKKBKJKFKKKK=KJKFJKKKKIKKJKKJKKKGJK:KJKKK3KKKKKKGKDKKKKK>KKKKBIKKKKGKKKKKHKIKKJKKKKKJKJKKJKK5KK0KJKKKKKIKKKKKKKKK:KJKKKEKKKKKKKKBIK-KKKKKGKKKKKKKKK>KKKKKKKDKKEBKKGKIJJKKKIJKKKKKKKKFKKKKKJKKKKJKKHHKEK(KGKKKK>KK?KKKDKKKKJKHKKKKKAK8KKKKKKK8KKKKJKKKKKKKKBKHJKJKJIGKKKKKKKKKJKKKKKJKKKKKKKKKKKKIKKKHKKKGKJFKHKHFKKJKJKKKKIKKKJKJKKKIFH@JKKKHJKKKKDKKKKIKKIKKKKKKJKKKKKKKIKIKKJKKKJKHJKKKKDKKKDKKKHFGIKKKJKKGKJKBKJKKKKK;JKK@DKFKKKKKKKKKKK=KKKK=HKKKK?IJKHKKKKKKIFKKKKKKBKIKKJKKKEJKJKK:KKKKKKJJKKKJIJKHJGKJJKKK8IJKHHKK?JKJHKKKKKKKJKKJFKJK-IIKKFKJKGIKKKIKKIKDKKKKKHKKKKJGIKKKK1KJKKKKKKKKKKKKEKKKKKKKEJJKIHCKKKKK@KJKKKEKKKKGKKKKBKJKKKAKHJKKKKKKKKKKKKKKKJKKKKFKKKKJKKKHKHKKIKKKIKKKKHKKJKJKKJKJKKKKKKIKKKKKJJKKKJKKKK>KKKK?JIGKKKJ@FJJKJIEKJH>JKKDKKJJKDJKJHKKGKKKKGHCJKKKK>KGKKHKJKKKKK@JIKKKKKKKKHHKKKKKKKIJJHKGKIDKKKCKJJEKKKKKKJKJJKJKKJKK,HKGKKKHJKKIKKKKKKAKKKKKKHIJJEJIHGJKKKBKIKHKKFKKKKKKKKEIHKJKJKKGKK?JKKKKKKEJKKJJKJKKK%;?IGJKKJKK:JKKKBKJFHKI4FJJKIKKEKJJKDKIHHGJFKKKJKKKFIIKCKJKKKKIKGKJKKKJJJKKKHKKJKKKAKKKKIKKKKEKKK1KAF:KK6JIKHJKIKK@G=IKKBFKBKKJKKKK6KGKFKJKDHJK:EKDKKKKKKKKJKKKJIKKJKKKDKCFIKCKKJKKKKKK;KIKKKKKIIKKKKKKKKKKJKKAKKKKIG9FIFKKJKIKKKJKJKIKKKGHJKKGKKJ.KJJKHKKBKKDKJCKKKJIJJHKKHF'KGJ?IHKKGKGKKKHJJKKKKKI*IJKKKKK9KKK @rCer/2092/2716_50_CCS CTTCCGAAAGCTTGGTCCCTGAGACTCTGTGGCTGTTCCTGAAGCTCCCGGAACAGCTGACAGACAAACGGTTTTTCTGGTTTTTTATTTGTGAATAATGTGTGGGATTTCCCAAAGATGTGTTCCTTAGTGTGTTGGTCCTCAGGGCATTGATGGTATTCAGGTGTATCGTCTGTATGCAAACTAAATAGTTTTTCTACATGGCAGTAAGACTGATTTCAGGAGAGTAGAAGTTGCCAAAAACTAGTACCTGAAGCTTCGTCGAGCAGGCTGTCCCTCAGCAGGGACTACTGCGCTCCTTTGAATGAAATTGCTTCAGAAGTTTGCTTGGGAGCTCAAGGAATTATGAGGAATTTTAAGGCATTCTTGCAATGGTCTACAGATTGGTCATTCTAATTGGTTTCTTTCCTTCCACTCTATGGCAGTGTGTATTCATACTGGCCATTTGGGACCCAATCTAAAATCTTGTGTGACATTAAACCTGACGTCACTATTACACAACCAGCACTGTTTTTGTATGATCTTCTAACTTTTGATTTTGAGATAACTAGATTTTTATCATACAGTTGTATAGAAGCAGAAATCAATACAGAGAGATCCTGTTTACCTTCCACTTGGCTATTCCCGCATGCTAATCTGTATATGTATGTTACATCAACAGGCCAAGGAAAGAAGATGCATTGCTAGTCGACGACGCTTTTCGGATTTGCCGCATCGTATGTGGTGTACATCTGTGCATGTTGTTCAGGTGATGTGTTGCGTTTTATGTGACACCGAGCGTTTTAAGCAGATTGAATAGTATCAGGAGTTGCATCGATCTAGTTAAGGGTAAGGTGTGTTTGAGAATGTATTAGTTAATATGCACATCATACTGGGATTATAGAAATAGGTCTTTTGACTGCTGGAGTCACAGTGGATTAATTTTGAAAACCACAGTAGTTCAGTATCAGACTTTCGTTTTATTTCACTCAAAATGGGCTGTTAGAGAGCTTCAGTGGATACTTGATAGTTCTAATTGGGTGCTCAGGGTGCCCTAGACCACTTCTGGTACTTAGGGAAAACCTAGACTTAATGGATATTTATTGACAGGCAACGTGCGCATTTCTTCTACCTCATAGAGTTATTAAGGGTTGTCAGGTGTATTTTGACTAGAAGCAGTTTTTTGCTCTTTTTTTATTTTAATTTAGTTTTTTAGAGCACCGGGTATCTCACTTGTGTTGCTGAGGCTGTATTACTCAAGCTCCCTGGCTCCGGTAGCTGGACCATAGGTCACACTGCACCGTGTCAGCTGACGGTTATTGCTTTCTTTCCTTAGTAGAAATAAATAATGTTGGAGGGCTTCACTGTACTCTCCTTTGCCAGTAGCAGGAATCCAGATTCATCTGGTAAGGTACTGTAGATGCAGAACCAAGATTGCTTAGAAATATGGGAGTTCGGAGAAAAATGAAAGGCTAAACTTATTTTCATACAGCATAGATCTAAGAGAAGTAATCTAGTTCACAAGACGCATTTGTTCAACATCTATAAATCATACGTGCGGATGAAGCATCAGTGGTTTACGCCTGTAAATTCTGTAGCACTTTGTGGGTTGAGGTAAGGAGGACTCGTTGAGCCCATGAGTTCAAGTGACCAGCCTGGTGTTAACAGTAGACTTCATTCTCCATTCAGTAAAAATACTTAATTTGGCCCGGGCGTGGTGGCTCAACACCTGCTAATTCAGCACTTTTGGCGAGGTTCAGGCGGCTGAATCACTTGAGGTCAGGTTGAGACAGCCTGGCCAACACTGTGCAACCACTCTACTAAAAATACTCAAATATTAGCTGGCATGGTGTTTGGACGGCGTCGTTGTAATCCAGGCTACTCTGGAGGCGGGACGGAGAATCATCTTTGAACCAGGAGGACGGAGTCTGCATTGAGCCAAAAGAATCATTGCCATTTTGCACTCCAGCTTTGGGCGAAAGAGCTGAACTCCCAATAAACTAATTCTTCACCAATAAATAAATCCTTGTAGTGCCAGCCGGACAATATGGCGGACGACCCTGCTACAAAAAATCAAAATTCCCGGGTGGATGTTGGTGGTGCGATTGCCCTGTGTCTCAGCTACCTCGCAGGCTGACGGCAGGAGAGATTGCTGAGCCCTGAGGTCAAGCCATGGCAATGAGCTGATGTGTGCCTCTCCACTCCACCCTGGGCAAAGAGTGAGACCCGGTCTACAGAAAAATCCGCATACTTGGTGTAAACCCCTGTCCCATCGATGACTTCTTAACAAGGACACTCTTGGTCTAGTTATAGTATACAGGTATTTCCGTAAAGTCTGCAAGTGACCCCTCTCAGCCAGCTGAAGCGCCCACTGTCACCAAGTAGGCCTGTAGACCGCAGGAAAGAAGTCTGAGGATGAAGGTCAAGCACAATGAGAGTGTGGGCTGGGAAATGGGATCTAGCTTGTTTCTTCCTAGTTTCAGGAAGCCATAGGCCCCAAGGGTCACCTGGAGTTGGGTAATTTGGATATGGGTGTAGAGACCCAGTTTTGAATCCAGGTTCCGCCTCCAATAGCTGTGTGAACAGGCCAAATATCTTTAATCTGAGTCTGGTACCTCATTTCAATTGTGGACTTTACCGAGGATTTGTAAAAGGAAAGATTAATGTCTTACCTTACATGGATAACC + ##"$"#+%'+,-'.*&,++.//..,//////,/../+..).*-/.-)+,.*)%+#.#(-.-//.-.)*//-.(+%-+..%.%&*%,)/'(,../$/-.//////+*/,'(-*'+)$)#*.)%**--/+.+///..%/,/.,-,&/+).-/*//+/,(/**/,/,/////(-/--,'-.*,*(*-++%$!!%'$%$(+'-#,+-()')!*$+()&/*.),.(-(--.-(,.,'-.$&**+'&$'$#''-%,"*.*)("$!##*+--+-'-&---'+,)+'$()$-'$*%'(...--+++*.'&/.,//"--/*)-/*'-/',.&-+/--(-!)++(-#,-.#+#.(&$..*#)%$$$$$&#&,--$*)%/--.))-../#+-./.%/-/.-/*///..%/)/*(/.##,+(+,-,'/./%./&-*/+////#-,--#-,..$%,,'("(*%&*)*%+//.$+**."&,.).')-..-#/',/-/&.+///#"///("...-,*-/.+#--(#+''*+*,-$#++.*,.,(-.),+...&)+..',.)*,.)--*'(##+&#&--,,)*%-++$'',"--*).+*,+.........,/./)//-/((+/./'--../*/(+-*/*,,,.++,.)-*+-'$+),,')+)$&#"#!**++++.*-%*()+)#+%%##%$$(##"$"#,()*&&"#$"%&#####$#"%(*%%.*..+-.#(+/.,+'$$--+/(-/..-.-&%*#%%'#,+%##$*$',+$$#'"$##&&$$(,''+('%)&$"$(%%'%'%'"&#%"$(&'%*(%%()#+&%$%($+*%"%#*)#($*&%#"&(+#($('#%%##("$),($##'$)%"#%'&$$#()%&''$%(+*$$..+..-/.,$/#/,/./*-',/./.#/.%./+/.../,/,/&$)..)()&-%,&.-//+//"$.-////)//./'//((..&((,--)'&-.."'*--/-(*.//.%)/'.%../*/*.&.+").//*/,%./**,/*+/*-'*#-./*)/%).'#($."///,.,/'.//,.../&"-'),**.+-*./"#/(.'#-*./..$)-/*/.,$/,/.,+///#-.//($+++''..*/../#-///&//+-./,+.+//.//,///.$'*$-&././.,/-/+/)+(--/,///*,,-)-./*&*,,%**,//*,,+)//.&&/-#/,).'##-//./$/'/.)/&&'*/+-/*/"$%./*..-/-.-#///&-)*.---///,/&-&+.'./%).*.$///..-(/.-",(.//./"*+.*$/,/.,+-/.&-.-*+//,.*/,./.#$//////*/+/-'(,.%/////////./"%/((/,.),/+///.*&*,..//'/+$#,/./-//$+,/-//&*/////..+/-..-.///*/-.+///,/////+$../*./*-.#*%,////+//+///+-"*,..)#&&"/.///-//////.//-.+..-//..#.'-//*/".,.-.//-#/*-)/).#+)*/")+#%.-/-/./////./,$//"(.,%$/////-/+-+.-,-///.+#/*#/,/./-*/+%+--.,)%-/.'.*/..*.-#-+.#//*/-.)+'."/.--*,.-,)'(..+0-,/.,&+*$/-.&-((.%/.#/".+./-,-/$%,*)(&)#,#./-+/./&+/+,%,-)#-'..,.,+&.-++#-.,//#//./"*'/.,.'-,#*+#,+-*$$+%/+.-,+///-/./,'%---+.,.-&-$.,,.+./,*..++-,-..-$)..--''($***+-,-,&%+'..*&+)-.///*-/+./+.//.&),-#()+$./,"-.*(/*.//-&--.)+-/.//-//+./+).*#///+#/."/.-$'.((/.--../(*.+$-/+///,./.-/)//.,+"*+./#/.-//'/+-.)##*/..%/+++//.%-.%.-/&..//&/.&+,./--,../(,.%/'./*//+/'.*-./)%#..+..,#$(/+.-./,-,/&%.)./..+%//-/+)/"./.--/--#+-*%*%,-.#'&%%+$%###*'..,(//-$,,.%,&,)"+*#.()"...--%%(#&'$(#)-(.'.,&--//".+-#&,-'#-/'+-./.".*--//,/,*/--/,*%-$#$-+/.,/./%"'/*-+/,//-/-.&//-'/.,)&'(%$#".-(.//,.#+-+/'-//*,..-(%%'/*++&-/./.$/,/.+/%,.,(-///.-,/$#/,/-///#./++-#%..)...(%"'#%&#$*"),$-#(--,'----$+-#+&'#'*#"++#)#*,+++&),*')++-..(/)&.&$..,%.&.*,+../.-*-.,,)-).)$,.-%+&)(&+-.//%))..*+/./*,..(...$,/+,-(-../..#'..-)-*..-+%..-+(.+-).+)./+...#.&,(,*..*.+-(-,%*-'+'"#)*,'&,*)'*&)+*.+)*(##'..)*,"'(*)'*+.*+-%,/*,.,*/+/(.+.&*'$#-,$,*.,)/*+,/,/$,*/*+.+(&!/)/*//),//,&*+."#('%'."**-#+(+',.+'-.*-',$.)).*-/*,/%&.)##-),",),)((.#,%'/)&/.)'(*.((&).)/+'$//.,($(&,/)+,+//**,(*&' @rCer/2094/2126_55_CCS ATGGGGAATCGGGCTTTAAGTCCTTGATTAGGAGAGTGTGAGAGCTTTGGTCCCAACTGGCTGTGCTATAGGCTTGTCACTAGGAGAACATTTGTGTTAATTGCACTGTGCTCTGTCAAGGAAACTTTGATTTATAGCTGGGGTGCACAAATAATGGTTGCCGGTCGCACATGGATTCGGTAGAACTTTGCCTTCCTGAATCTTTTCCCCTGCACTACGAGGAAGAACTTGAATGAGACCTGCCTCATCAGTCATGGGATCATAGTGTCACAGATGGAAAAGCAACCATCAGCTGAATTGTACTGAACTACACACTTGGCTAATTCATCTATTGCTCTACACATCTAAAGGAAGGCTCATTCTGTTCTTGGAGTCTAGACAGCATCAGAGTTGGCTCAGGCTTCTCTGCAGAATGTCAAACAAAGATCGACACATTGATTCAGCTGTTCGTCCTTCATCAAGACGGAACCTTCCAGCCCGGCCTCCCTGACGGACAGCGTCAACCACACAGCCCTGGTGCTCATCAGACGCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACTTGACTCGCCACCTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGTCCTGTCAGGAAACTGTTATGACTGCTCCAGCACTATCGTTGAAGATCCCCAGACAAGTGTGAATACATGCTCAACTCGATGCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTATGGGGTAGCGTCATGTGAAGCCTGCAAGGCGTTCTTCAAGAGGACAATTCAAGGCAATATAGAATACAGCTGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATCCTGCCAGCTTGCCGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTGACAGAGTACGTGGAGGTCGGCAGAAGTACAAGCGCAGATAGATGCGGAGAACAGCCCATACCTGAACCCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACATTTGTTGGTGCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCGACAGTGACATCAAAGCCTCAACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTATCATTGGATGGGCGAAGCTATTCCAGGCTTTCCACGCTGTCCTGGAGACCAGATGAGCCTTCTGCAGAGTGCTTGGATGGAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCGTTTGAGGATGAACTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCAGGCCTTTTGATCTAATATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAGTGGAGAAAGAAGAATTTGTCACCTCAAAGCTATAGCTCTTGCTATTCAGACTCCATGCACATAGAAGATGTTGAAGCCGTTCAGAAGCTTCAGATGTCTTACATGAGGCGCTGCAGGATTATGAAGCTGGCCAGCACATGGAAGACCTCGTCGAGTGGCAAGATGCTGATGACATGCCACTGCTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTCTACAACATCAAACTAGAAGGCAAAGTCCCCATGCACAAATTTTTTGGAAATGCTGGAGGCCAAGGTCTGACTAAAAGCTCCCTGGGCCTTCCATCCTTCATGCTGAAAAGGGAAATAAACCCAAGAGTGACGTCAAAGAAACTTAGAGTTTAGTTAACAACATCAAAAATCAAGCTGCACTGACAATTTAGCGCAGCTATGAAGCGCTTTCGATTCCTCATAGCTTCTGATGAGTTTCTTTCTATTTCTCATCATCTTCTTCTTCTTTCCCCAATTTCTCTTACTGTTTATTTTTTCTCCCTTTTTCTTTCCCCGCCTTTTTCTTTGCTTCTTTCATTCTAGTTCATTCTCCTTTATTTTCTTCCCATCTGCTGCTGCCTTCTTTCTTTTCTTTGCTGCCTTCGTTCCTCTCTTTACTCATTTCTCCTGTTTTCTAAATTTTAAATAGCTTTAGT + 77::60;79630%497.7036;9;9859.8:3840-54+2860,257,0&2::371*09.993./$1727:100)0285,83444.:12420&322309.826:7+.265909:4764);696+842/46652443-04489*0674397.-6,-:294.54:1869/16142.53-+/*41+52.14-8;895:0554-3-1.5*,24&2885.0)510648436++:236(5-3&45*2394858074-202,,5&2-658067827:95869:39:6+397-.(16:8+*(5941*3395,4:59586/3933,:,22717665,+&03'774311,3786:7:916,8*,&28623.3-78+55+401*55-2213003+01/#,14/5*,3/.1*55.,,(%321260.45/04'455)10,,113*3-5.(-4/#*14/2600/-4.4/540362022.+5*0)1&5(-.11'1'43+*-'0,3.0%41(0,10/1*531%*4/454,/3,.$#,)052553/0570/228(*).081/-874929,7505&-627-628:693598958.733457915&)/,//78+:33/3(*4-4764+196//71/.(-3&26+360765$.:/61%$#.10.4998:;44349080/892505)23+-33&+41$465370*1%943486299:.0.568538%,+31/398:83:;6429:4,75-03),,6:832'02/0&+6802%679:5818255:549300.3(,2,-16738.654336348-267*,-/&622-'0&/-*,12/-461865351657,449(.2062249-645867)9814382:6855961'2-0$..*3/,'%#'528:32/.)25902/86565,574*9648*-:668.9;9549/3:9+9500,,#'00265868-4598992977&28/:081212(9::991$-,855..:2-09.65-15%5835,446/.0&,15''1;8948429-83424466#/8+0.240*74-332'7113&+0488(732831$-253':-7322:/466442472*4.49733266334.28013$+6,76878-0/42/$-1#.0$$%*+/30+*12*94:3614291*%3,)'%.*.212%-/.,1+4-0*-2&451%/)-0*+('..$*3#.1/)55+52.2'/0"(,'1)(--11.-51/'1+.1('34451045-/)3,14,134)3/41+646/,4441+10/-)2/431/15,0355)/-0(01-2+-2,124451*1/-+1-&,%'%*1..&3,03+2*426/0102/..#0()0/+.+2,0#('%*(',0#+$+.+-.-/+,-)+$$/1,+.0(*,-&/*01-10/0/..+(##%&**11,0/'.*%01&+,(&&%/.,*$+*$))-10,,2,0.)&*'0*'**0/%)(+#&*,*$.-&)/1/-%-.(('&01+-+-,$(/2.-,&00-++,&//*+()1&+++110*1()1**,0-*+*+0)0-),+*&%,0+0-0*+&)&++,*+&02./.*.11./%-)%(00'$*&%-*,01-.,/.,0.*.,0/-.0(/+0,20110-.-0+-'('--0/0+&/00)+-*/0**&,./*+%022.11-0/,0-'*//.+#$$.1)/-+-/-02/200+1,.0-011.111&'*)%*%',/%+%,+.)).+&+%,.0--(+-./)/0-/0*-01*/-&-()%*//,+0--12/0.,$'2/.-+)+/),%/'-/,1*+'//)()($%#%"$$+*()*),+,-**+%+-$+("#',+)%*(+$)',,&$'),,)'%#&'#),-'#*+((*)+,-&(++%&,$%+&*($%)(*$#,'&($#$"$$'$#%%&%$,,'+-+-,&(+)-,',*-.,-,*&--+*)$$#(,)'+,+$)-%(%$)%')*())-''--*())')+(,*)$*($'&(%--'&++*#',,+*%,-,,)#&)(,--,,-(-.+,---&')-',(),(#)&($+''$*+(),-)+'*,,''$$$'),+,-,$+--*,..-+),(+&*(-+%',. @rCer/2098/25_2179_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + DC/FEB>B=1EF=BFEEB7D@@DFDCAF?A=F4-;EGE>@BDDEFECCACCA;=BDEFBGD@DF>BCEB3ACF>DA?D:6*C>CF@CCA>=$B9A:EBBCFB@BCD/C@GC?1D8D8DB?CA?>94A3?FA;=;C?>?<;DEBGEGDGFEFEAED;E>BBDAE?@D@@EBA@>B?BBE>1DCC?CECBDA,F>=EE0EF>C@D>C;DCD@@E?;C;@GFA@2EBDD@>()"#&822FE.B&9;E?A9D@A;@AE5?BCEG<:?CFE@?GBBDEAFE?8DD?D8;B5EE?D2C;FEGDFB@;EF=E9?:C,BBDA:BACB3B=:?E7A>ACBE49?<@>7'#&ED=@?;FC?<=F?,7ABDCEBE4ECE;DC>3??$&AFCF?E>ABDGFE>7C?B8CE>GB9EFEFF:;>EF;:F@E8EED7$?7A=:AA=6@AC5CECBBCCDA@DF:DADDFE6BBA?CFB?E:?BBA;B>EF=D3@D;8D;EE@B7BDC>8E8D9IFDGCB>FEAHCIFC8GGEHDJJJFHIFIIJGCG@IC.FEF@HF@GBBIHEIHCFIIGI?I>DDA>GI?H?HI.BHJDIJJJJIJ7KJGKI@IJHGHJJFBKGFKFIH<6KKJKHKJHHKHKAKJIIJJK?KKJBFECHKJCK6JBE7HCB1BGFGJCEIJJE$,GE??E@2C>=HBHIJ>KKJJDI+FFAHAIJIJ?BCFAEECCIBBFJFJIGEKCA+FHJH@I5GB@$FHDDCBABEHEGG9GIGKJKHJGEIG=CCCHHCIGAGJIIFFKJJ.HHKHHKJEKJ=FKGCG>@>FIFHJHGGKGKJGKDFK:JE;IFCJH0KJHGG0IGKFII@?FGJJFF@BHAKKGIDKGBCJHJHGKJE=F9KIIFJ;IJKBKECKFDKJAKJAIJJIEGGKD#'D@KHIIJCGIJJJJHH?GJGJIHEJFKCJJJFJCDIGFJHK9HGGCG;GHIHD7DDJGJCGJK;HJJJJHGIIEJI=AGKJFKDGDCHJKIDKKIIJCKKKJB*EFG;@IJG@;;HJKJDEB8JAHFGFKGKKJHJCEKKG@A;EHJIBI>AAIGE>BJJHGEIGFJ*E@@JJKAJIK@H@F=HCJGIGJJJHKHKKKJGFHFDEKIIKHHB9CAHIABBGKFKKKHCG>FKJKHGKI+KIF96<2:50)7$44889==>95737=7,886033-63(78)::):99.77<*+98/,+86<=9:908:><08160;;):01-1.36=):6?6<6;:7%<7:=$//7:-/'%83*1$,03,5294'94666197/1&21$;04'885100*:53,(.<8*=23897:7187=64+3+*6:59(7;;6:7&87<=&44+7)5:5;724'94*7;9&79-%4:;==8?:=*4.6):<)<93;>5+:9:7>=>:=+<4%685%/04140:3:;>9;%7565>=44$65.2469:189;858803#;/-,8<92?=3;/<*=884$:9758:;;0<):=84'4+:11:66.2&:/5)1*.0$'77059<2*=:6'*:=367&3::=:8824?5:3)=,(3:;8);:=973599;<997=83=2,9';<4176#4808+,%'01,8'*$3/0(*1)*&6.)8;8657085369992;=:%62$20$0-$176&.)+$('/)5061*99928>949(054+77+-290,59/63'952/*/54&977*8;:)>);,;&',1;9915'8*&54%&./;1?=8:3:->=+#748<69(:::67*61:6028/>*59/-822=8?827>>:?7%875;=754-#148;8<;7:=6&:87820229<6-<(81++2)4308795:<<,)>57A@;/@;<9? @rCer/2103/1824_66_CCS ATGGGGCTTTTTCTCGCAACGGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACACTGGCCATCTGATCTACAAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATATTGAGAGGAGGCTGCTGAGATGGAAAGGGCTCCTTCAAGTATGCTGGGTCTTGGATAAACTGAAAGCCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTTGAGACCAGCAAGTATTATGTGACTATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTTGTTGGTGTTAACAAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTTAAGGAAGTCAGCACTTACATTAAGAAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGATGGCAAATGCCAGTGGAACCACGCTGCTTGAAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGTGCTGGTTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTTGTGGCAGTTTTTAAGTTATTAGTTTTTAAAATCAGTACTTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTTAATG + +-,*'&**'''#$&)--,---,'-.,&('+**)+,&*--,,&(,')*',*+&()%('##)(,(,+()&,'',*%'*%#)+,+%())+),')'('&(+,',-((',,*%*+)(--$#*(('#%-,)(((+$+$*+**$&'$-,.+*%'()%$'$$'**+%'($###&%')(++(,..(+*,'-+&+(&)(+,'+$*&'$&$((*-*&((,,(,,,(($'-)..,)(-'.)(-'(+)(###%()(&-&+(()*(('+)--'(%%-302/30)0**-%21$0588?;:A98<-<1;7;<@5;2=8?C?;<9(.2968:A7>:2583?0=88>=:@6/:<9866159.).+=;:;683:8;<<932@;=47:=>*?69;<>5=>:52+:229.43:@8=>@@??9<38=A@@6BAA>>/.:/46;;>454*77:057189<03196//=3089><576;:=23;9;>;46&-+;7(.==)47*:;;841%:812-35<28,78+12%99:;>1A8:9<:6>8@4@?B:89'4<;<2':0<1*<@3897=1A35.4'1=9;:97=793=>@>?1:@7<.38=2<14-01+1;5317<;81:-2/775*<:==79:?9?<86@:@0;:A(5C?4:1:4B<8273;:7BA146956/<;754/7'9B>4=?<6,:/5.702;51A5<99=?<8780=<90<78>7494;7:>>0976718;3719731+5328<8=>B;3:<=<7:;7;3B@==<5;=<9549:=0:>BAB42+AA7>@75/95:/:7.9-/104781/=2;8=?<417:A6;@@9:=76:4:.45346=<6A/4,8?>?8?2<7;3>07145-+17>:42;9;7659:3*.'=B><7*1;0:>0>6599;:><1&&=-;2:647<:4..9>9A=?5208A=9875=<3@?;A@@=-9C6@<<::<3:115<638);4?=>9:4<8%<$-3,+#12:9?=>54>7A>344=855/@553;3?126?8@?7<<7:4;7;8;(6&6156;826=:;<8?:36A@788/:=6@=9A=>@/=841BB7;9'::5385586744;4.027;7><:;;>678565,:14877406264266=4568.0,.4/16430=9<98993617<977<:;94=9;6249:8-77:=4$488136*548/60,:=?96695689>979:<89==8><24-919>3:=9?>=:561473>6:584,1+-7=56=98:=9=5%,*-16'2115/5551,01/34345/3-431++.2(3760/,045+15243128(17+0.90:862&86628-9071/'*%().62133143(7661&:2/872'2.-29*1/4772)54*&$6,302333/11$5'2500.-566566&733&-4/0'/(66766%;89;602/58.54&'2635445)52283241,+/,334$+*-362/26.4839:/87;:;81- @rCer/2104/25_1694_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTT + KKHKKKKKKKKHIKJGKJKKGIHKKKJDCEKJKKFHJIHJKJKGKKKJEKKKKKKK:KKH=HKKCKKKJKHKKKKKGJJJKKKKKKKKKKHJIF@KKJKKJEKJKK>KKKKKKKKKGJHKKKHJKFKKKJGKKEK@KJ5KKKKKKKKHKJKHKKJJKKJKKKK+KKKKJEKKKJKIKEKA@=>KJK6KIKJHKIBKKKJKHKKJKKKKKGJHHAKKFJKKKKJJCKJKJKIJDKKKJKKK?KKKKKKKKJKJHGEKKKJKKKJKKKKKJKKKKKIKKKKKKKKKKKIKKKKJKKKKKKKK=KKKKKAJIKJJK;KKKKJKKKHDKKKKKIKHKGKKKKKKIJJKKKKKKBKKKKKKKKJK/KJKKKIKKKIKKJKGKIHKJKKKJHKKGKJKKJKKKKKKKKKIKKFKKKKKKKKKKKJIIJGJKGKKKKEKKKGKHKKKKDHKKKKIKJBDJGKKKDDKIKIKKK=FHI=JKKKHI:KK4JKKKKKKFKKJDIHCKKKKJKIEJKBJKJKIKKKIBKKKEKK7KKKKKJKKKKKKKKKIKFKKAKKHKKFKJIJKKKKKGKJIKKKJDKGKJCKK5GK>KKJKJKJIKHIHJKGKKGKKJJ@KGAIK?KKJHKJKJKKHK@JIJKCJFKKK,KKKKKKKKKK@KKKKKKKKKKIKIKKKJKKKJKKKKKKHHGKKJKKHJKKKKKKGKKKKKKKKIKKKJKEKKKKJKKKIKK3KKKKKKKJKKKIKBEJKK2JKKKKKKK9KKKKKKKJJ?JKKKKKJKKKKJKKKKKKIKJK9KJKKKKKKKKKGKIKKJKKKIKJKKKG@KKKKKKKKKK@KKKGKK0KKKH%IHKKKKKKIKKKKJKJKKKKAKJKEJFKKKKKKJFKKKKJKJAKGKKKKKKJKKKGKGKKKJIKKHKKKFKKIFIKIKKKIKJKKK/KKJJBJKKKIKKIJK@KKKIKKBI'KKKDKKKKIKJKKJKKKKJKKIFGKKKKKKKKKJKKKKJKJHKKKKIKKKJHJKBJK:KJK$KJKKKKKKKJKKJD1KKKKJKK@D7KJKHKKKKKJJ3HCKKKJJKJJKKKKKKJKKKKKJKKKKJKFKKKGKKIHKKKJKKCKKJGKKKKKK @rCer/2105/1598_59_CCS ATGGGGGGCGGCAGCTGGAGGTGTAATAGTGCAGGTAGTGGGGTTGGAGAAGTTCCGAGGCGGCGGTGGCCCCGGTGAGGACTAGGATAGCGGAAGCGGGCCCTGGGCTTGTCGCTCACCATGCCGACGGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATACTGGATGGTGTGAAAGGTGGTACTAAGGAAAAACGATTAGCAGCTCAATTTATTCCAAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGACGTCAAGCAATTAAAGAAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATATTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTGTTAAGTATATTTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACGAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCCTCCCTCCAGAAGAAGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAATCTTCAGCAGG + /565664+564430-/0,3610436356435,-1.553143.*1351/,1/36421013.32,561/61453+244456462565415005306563/0'46152213553'.1-454541442013664-1144145655/.35246.031163526364642.64444.*452656665-13*0,4424244-131000236434533656123+410...1*.-*1-+2.31432/640246.662561//5+0146156443*1-555'6/66545/240353'2(332+6364423)1-651325253+.15233340.5110666433460646601-14441542431/%+/,03+.45.5,65-1+.%0405..'2/36014.%536412543.321-201/54304./.0411%,6/312.5653356(/4.5145541425152501/4132)0-3/2./3.-**2,-&(1.3*2-/),.+(%$*/%/*/*45.4125566-4611422255134,'+%0600,+3)16-,'&1)34154111652435403+22,533/(14164,2*0.651255.5/++-111.5/6115441.5635566//&4/-0322356260+/21/..-0131.25.4015156264.1.2122-2053-5/46562452'26510--3'01)-4/.5544/30*00,1*531263.3126622563050.325642111204,2.34/00400,3.34/011325120.525533440(510,-)/-.*.3-.&/-10.2131.*0163(20.520144114/.,-/00400102+0(/-43-..'(-,/-441&*($**+1/'1/5./033511.%-/,.)+/+0-,',./+12,1/-,10*/1+(.*,./,/,..,/&.,02/+0&2/-12/.,,,0&.-1-++*,&.10,/2/2-1.2/00.))-1./*#(&*)).-21122-/*+1*0-10/11..-1-0*+..22/-00-10.+-1-/-/0/)&/..,01/./0'/0/2.2//.*/.0220/112100-/2/1,.1011110/.1,1220,1-1---00*-0.+000%&,,,(',2,0(*-.--/*110++1*1.*)&((.+**-/1.*--*-*+/1-2/.+*.$02.*,---.00/*,/1--01'-1*.+../..$00-0(+*(.1+12+1*0*//).-*/1001-.,,,,+.,/.)/../1-/--.,,,%-.-0/-//.-,-&-0/--,0./,,$0,**+/'///**-,%*-,).1+11+-1/2-1/.)..0+.//+$),.'.0/11102-1,-.../-'11/2-+.+/).1*/)0(,-(-1./0+.*)---',.&./*//1)020/-1121-1000-01,12/1.,-/0+/,/-1112./,.-,21/2/0/201*+01/+--2,-1,-'10.+1,//,-+0,/-/220+20200-000+1/,1222-1-'10,&+*++.10.-.-.+$.,/,2-010-2/'00/2//,,),/--0*,**-, @rCer/2107/24_2219_CCS GACCCGAAATGGTTATTGAAGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCCCAGTGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTTCTACCAAGTACAGGGTGGCAGGCTCTGTCTGGCACTTCCCAGTGGCCCAGATGAGCCAGTCCGAGTATGTGATCAGAACAGATTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACGCCACACATAAGCTTTCTACTACCAAAGTTCCCACAGCCTGTTGAGGAGAAGGTTGTGCTTCACAAAGATAATAGAAGCCATGGATTCACAGGACCTTTGAAATACAGTAAATGGAAGATTAAGATTGCGGCCTGCGCATGTATACTAGCTGTGTGGAGAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGTTAATCCTATATCCTGAAGAAGAACATGATCCTCATGACAAATCATTCTATGCAGCGATCTTGGGATATGATAGGGGATCCTTTCAGATGATCATGGGCTGGCCGCTGCCTCTGGAGAACTTCTTCAACGGGAAATGTGAAGACCTCGACATCTTGAATTGCTGGTAGAGTATGTGAGGAAACAGATGCAGTACCTGGATTCCATGAACGGGAGGATCTGCTTCTGACAGGGAGGTGAGCTGGCGCCCTCTAGTGGAGAAGAATCCTCAGAGCATCCTGAAGCCCCATTCTCCCACTTACACGACGAGGGACTTGATGGGCTGGGCCTCTGCACGGCTGGCCAGCTGGCTTCGAGGAACCTCCAGGAGAGACGTGCCTGTTGGTCCAGGACCCGCAGAAAGTGGCCTGAACTGACCTCTGAACAGCATCTGTCAAATACCTGCCCCATTTGTGTTGAGTTTCCTCTTAGTGTGCCAGGAGTATGATCTGCTGGGATACAGGGATGGAGAACCCTAGCTCTCCCACGTGTCCTCTCCCTCGGGAAGCCCGAGTGAGAGTCCCCCAGCACACACTCCCCAACCCCCTCCAGCAACTACCTGTGACTGACAGCTTTTCCCAAAGGCCAAGGAAGGGATGGCGTAGGTTCAAAGGGAAACCCCCAGGCCTGCTGTGCCTAGGAGCGGACTGTAATGCTGCGGAATCTGGATGCGACCATGTGTTGTCCTCGCTTCCAGCCATGGGTTGAGTTGGCCATTAAAAGAAACAGACTTCTCTCTACATGGCCTTCTTTATTCCAGGACTTAGAAACTCGCCTGAGTTGGTGGCTGCGGTAGTGAGGCACCACCCAGCTCAGTTAGTGACGGAGAAGGAAGAGCTGGGATGGTCTCTGCTGCTGCTCTTGCTCTAGTTCATGGAGATGTGTCTCTGTTCAGGCCAAGGCACAGCCAGCCAGGCCCTCGTCTGGGACCAGGAGGCTCTGATGACCAAGGCTTTCACATCCTACGTCATTTGGAAGGAGCCTTGAGAACAAGTCACCTTTGTCACAGTGAACTGAATGAGGAACATGCTGTCTCCTCTCTTGGCCTCCCTTTCATGAGATATTAGGAGAAGAGAACATTCCTCCTGGCTTAGTTGTAGCAGACCCAGACCTGTGCCCAGCTTTGGGCCCCCTTCCCAACTTCTGAAGCACGTGCTGCAGAGCCACTTGGTCTGAGCACTGAGACCAGCCCCTCCTCCCTCAGTGCAGTCATCTCTTGGGGATTTTCTTAAAGTGAAGAAAGGAGTGGGAACCATATTGCCCCTTCCTCCCCATCAAACTTCCTTCATTTAACTTGCTATAAAATGAGTCATATAAAGAAACTCTATATGGGTGAGGTATATCCACTTCTGTGAAAACATTACAATCAAACCGCCTTCTCTCAGTTATTTAAGATGCTTTTGTTGCGAGCGGAGCTCTAGAGTGAAGCCTCCTGTGTGTGTGTGAGATAATAACACTTGTAACTCATTACAGCTGGCACTATTTACATAAACCAGAGCTGAGCCAGGCAGGAATTTGCTGATTAATTTATTTTAATGGAGTGAAGTATACCATGCACCAAAATAAACTTTACTGTGT + ::8:6$*59-(85B@'CE(D81G6247GE4=;1;<0@;9BDFC<0=3G>6B8J/GEH@F:A?:C4IG,?I;C=$B-?5IEEICFCG>E8GFDAJB9EE.J'C:BE;=A@'=>JIIAAJ5AJ@?8(4CFBJHJ?=BAEHIK?K5=D>;>AC>EIG>>BC5G07=HGF3AKBH=IG==K+H4>0BGJ,HIJK@KJBAG@JH:H9HF=KKI/JG4K>GJC'D4$?:KKI1@DJFKDKF4HKJ0K?KAJ=I6KGFGIDI7;&IJBAJ==EJ>JG8/JJ?F4>EGJ87B?&GHG;KKKCKHDG%85EGKH2KI?I:I3KA:95EIG:KJ0J3FGIH4F&FK;1KFJ9A*HH@E6?%FF6BF9EIKKJ:H>I@DH3CJKJFIKKJK7AH7K=K%G9K@KJIF&CCKJKKIHD@IIKKKEJEGEEHJ:K.>*A??26<@'KK1&E5CHFIDAGHEIJK'J>&KIBH-I2KF8<<&G;@9,C@>:8&9IJIKGHKK&J?:KKJGB=&K<;&ECBBGHIEK?HJ;H-KJ7@.B'FJIEKIH.IDGG5)KJ/KG%J)KEJJCKH(IKA&IIFGGGA;KCEGAJF,HG8/?IIB-<:%JEIAKKHHG@HG7IBD,H10J?.K7GG5%KIGEBKKBC'E%&J@GHE;E>.J?8/G,JIE:30J5DKIKD,I?K%H;,IE2<6>G0?F+=5-D97)H(C<.H@3>@*II6?HH/FF?:$H2GEEKG?GGH8?:=5BGA(KIHJ?CKEI&KCD4DB&E?KJGJ;KKIJ&><2JG?HKKKIJJJJDF5'CFGJFB>@=JKG=C&JFBBI(HJBHA4IH7F;K@EE2K@15CE;IIJIDE;2CJK@KK@KK*IK-JC/GKKKK;K7IAKFBD:#2DIH+K>/FHKIJFKHGJFACFBJ7IGKKKB=KJC)DIK6KCA<>=&:@C*HEC$79G7FF=0JEF2IE?IHIE?K%C>KJFK2KKKI>KKIHEJK&G2FCAGFD&AJ@<+K>IHCIKJ.K'KA(KHD1KGH=JKJJ=9(KBI@6+J%65-EHIDK.KBE?A2(I7*KJGB2K86FJJK=(H.5IH7F?KJ$KJJ@6;KBKKCHJ1@IKHHEKBA>EEKJI6J:KFK8IFGDKK2KJJ1KC/4,KK9KGEE;J?%GACJK%C6KKCCIKIKIJJ@JCJKHKKID.K@KGHJEIBFABG/CCDKJ:K4J:E?$FK/EKGJJHE@E@H+BA1FDKCF?@GAHJG7D9HGAH7,K<,IKIJ@?-GH%KFFKJIJC?GB;CKK4AKKGGHCKJK3CIKHJF145%BGDK3*EI@C?)'?7B$A8KIG4KKKJ'KK.JKJKKHFKKJ%DCGJDK@5B/JIKGBIKKKEK*KKJKK=KD6H8)FJJF;G?;KK>8KK;?<@KDC=7IKHJJ7JD@DFJ/GG;IKF0;D;*KKKIB@J=2'I@E8KG(@G@IFGIIJBGIE,E;GIK2GH<2@I5KKC?9IAHJ5AG7D:@4J?E6?:-IH=K?'G:;IAEIG?7EIG@7EJHKK;JJBDH6*CJ9AKKHJEG7KKKGKFC(D@JJFE5>E?JJI?AI?BKFJKBGCJBAKK?KKHBK>K(IGIDKKK3JBK.F18(IKK8?I.KI=;=<5>>====<:7=?5;6<9<=668>=916>4?=97)?6=89=6@;?>:?5<=@=?:8;>6<:BB8A=@978<@A<;?3@@?@@9:A8A@?;3@A9>=6/>==@0AB>B@=A3BCA?:BC?=ABCACA?C>AC>=>?8?=36:9>/35=9381.8@3:583??>>8<97==4A<==@'@?/>8;73(;;=@44@+@;<7=6;6)6:8:808--9;/@?;<083:24=<=?AA@??0B9B:;>BC@874;87876332:718029<674%8;6(5378277(017;0843;907<92;7=;=:0:6;=56::74;>82,8:=??4;84784=<>;=6;2;;9<@A+?B>:9163$:;8890;=99;9:53>=<0<>:><:>6A=A?>@A>-B9AA@3?8B=6>5:'11:-<=:>::@@>.52==6=3;A@<=>B?>;<68;532-9<7516937>9?2?9:<0;:9<;':>8;=-?=?57>9::;8:BBB?=A=>==A47AA>C<>>>CBA/A@;A47;;/A><@=57(8>8@>A>A;?6;5??<8;::?=ACB:>@8::BA@@>;>A)ACCC:>6;>5>@:7>>>@?3=>885<=6;?6>=;B>9,9;;?<>8;><8:83===>(<86?3=CACBA@9;>=?=;5:999+?=;C@>?@A7@>@;>=7916145:3988<;8B?CC2ACB=@=B?>A:B???@?;?;748?=B7A>=A3:.<;6>>@A@?,BA7C=@?A9B?6?>91.&,-3-4(7979;466$<5A6B=@B@CB;A<;@7=6<;B?@?3:7=9@A;=5966@B=22<4.49:<267799:>B>=9:=@?6@>A0;>=;A?:.B>=?>;A<7??A%@??7>=B6=?7??6;1A:C@?;65&;B@=@5?/@?:@@476.69886':<866;;&5;7=>5754;3<9-==31,1:>@=>1A89;?:95><:@6<5/4:9;8A?@?B@;9;3;BC:0B?A?;@8?<(@>>B:5:70=7;CA5A=<;-==;::/;<7;=A?=@7=??6?<0=376??<:4=9?;87:242/9:96:/2686:%60/.337479*99:=6;234:::<==588499951;;986044.8=9<7?;93=1>38::5;=<.:;1>=956:2<>??;>9739;==:<8=;;2/87::8<6=;9=;?<2:;=6>:;8>=,/;;724897.556<6.075/,<64>8676*<54484/,69/=751::3:6;9<:6,9:6;:=0;9;442853=>=;6699?=99>497<76;63287183.*<8221'55:8:540<8>>7>5868630.88::=658<:980;4:7:>==95=<>;<1=:575>?7:7:6;=7>>::67<28=<3;;818,73<0312555.33(/07247/38=?8;<>:=?;=;=;';84576-:78 @rCer/2110/25_2009_CCS ATGGGTGAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGACGAGTCTTTGTCCACTATACTGGCTGGCTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCAACCATGAAGGTGGGGGAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCAAAGATTCCCCCAGTGCCACACTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACAGAAGAGGAAGATGGCGGAATCATTCGCAGAATACGGACTCGCGGTGAAGGCTATGCTAAGCCCAATGAGGCGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGACCAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCATTGTGTACCTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCCGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGTTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACGGTGTACTTCAAGGAAGGCAAATACAAGCAAGCTTTACTACAGTATAAGAAGATTGTGTCCTGGCTGGAGTATGAGTCTAGTTTTTCCAGTGAGGAAGCACAGAAGGCACAGGCCCTTCGACTGGCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCCGCGGCCATCGAAAGCTGTAACAAGGCCCTAGAATTGGACAGCAACAATGAGAAGGGCCTCTTCCGCCGGGAGAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGGCTGATTTCCAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCAGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGGCCAAAGGCAGAGGCCTCCTCAGGAGACCACCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCTCTCCACCAGCCCTAACTCCTGCGGCTGCCTGCCCCCAGTCTCCCCCCTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGACCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGGAAGGGGAAAGGAGTAGGCTGGGGGATTGAGGTGGGGAATCATTTTAGCTGGTGTCACCCCCTCTTCCCTTCCCCCTTTGCACATGAACATATGTCCATCCATACATATTCATCAGAATGTTAATTTATTTTGCTCCCTCTGTTAGGTCCATTTTCCAAGGGTAGAAGAGGCAAGTGGTAGGGATGGGGTCTGATATGAAACCCAGGTGGAGAGGGAGACTCCTGGGCAGCCGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAACGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCCATTTCTTCTCTGTTCCTTCCTCACCCCCAACGGTGTGGCTGATGTCTTCTGGTGTGATGGTGACCACCCCTTGCTCCCTGTTCTGGTATTTCCCCTGTCAGTTTCCCCTCTCAGCCAGGTTGTGTCCCGAAATCCCCTCAAGCCTCTTTTCCGCACGTTGCTGAAGGTCCAGGCTTGCCTCAAGTTCCGTGCTTGAGCAATAAAGTGG + 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@rCer/2113/25_1736_CCS ATGGGGCGCTCGGGCTGCGCGGCCTCCAGACGGGGGGTGAGTGTGGCGGCGCCCCAGCCCATTTCTCGTCCCCGTCCCCGTCCCCGCCCCGCCTCTGAGGTCCGCGCCCCCCGACAGCCCGCAGCGCCCCGGACCCGGCTTCCAGGAGCGCTTCTTCCAGCAGCGTCTGGACCACTTCAACTTCGAGCGCTTCGGCAACCAGACCTTCCCCAGCGCTTCCTGGTGTCAGACAGGTTCTGGATCCGGGGCGAGGGCCCATCTTCTTCTACACCGGGAACGAGGGCGACGTGTGGGCCTTCGCCAACAACTCGGGCTTCATCGCGGAGCTGGCGGCCGAGCAGGGGGCTCTACTGGTCTTCGCGGAGCACCGCTACTACGGGAAGTCGCTGCCATTCGGTGAGCGGTCCACGCAGCGCGGGCACACGGAGCTGCTGACGGTGGAGCAGGCCCTGGCCGACTTTGCAGAGCTGCTCCGCGCGCTACGGCGCGACCTCGGGGCCCAGGACGCCCCCGCCATCGCCTTCGGTGGAAGTTATGGGGGGATGCTCAGCGCCTACCTGAGGATGAAGTACCCCCACCTGTGGCGGGGGCACTGGCAGCCAGCGCACCCGTTCTAGCTGTGGCAGGCCTCGGCGACTCCAACCAGTTCTTCCGGGACGTCACGGCGGACTTTGAGGGCCAGAGTCCCAAGTGCACCCAGGGTGTGCGGGAAGCGTTCGGACAGATCAAGGACTTGTTCCTACAGGGAGCCTACGACAGGGTCCGCTGGGAGTTTGGCACCCGCCAGCCGCTGTCAGACGAGAAGGACCTGACCCAGCTCTTCATGTTCGCCGGAATGCCTTCACCGTGCTGGCCATGATGGACTACCCCTACCCCACCGACTTCCTGGGTCCCCTCCCTGCCAACCCGGTCAAGGTGGGCTGTGACCGGCTGCTGAGTGAGGCTCAGAGGATCACGGGACTGCGAGCGCTGGCAGGGCTGGTCTACAACGCCTCGGGCTCGAGCACTGCTACGAATCTTACCGGCTCTACCGCAGCTGTGCTGACCCACCGGCTGCGGCACCGGCCCCGATGCAGGGCCTGGGACTACCAGGCCTGCACCGAGATCAACCTGACCTTCGCCAGCAACAATGTGACCGATATGTTCCCCGACCTGCCCTTCACGGATGAGCGCCGCCAGCAGTACTGCCTGGACACCTGGGGCGTGTGGCCCCGTCCCGACTGGCTGCTGACCAGCTTCTGGGGGGCGATCTCAGAGCCGCCAGCAACATCATCTTCTCCAACGGAACCTGGACCCCTGGGCAGGGGGCGGGATTCGGAGGAACCTGAGCGCATCAGTCATTGCCATCACCATCCAGGGGGGCGCGCACCACCTCGACCTCAGAGCCTCCCACCCCGAAGATCCTGTTTCTGTGGTTGAGGCACGAAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGTCAGGCGTGAGCAGCAGCCAGCTCTGCGTGTGGCGTCCGGACTCAGCCTCTGAGCACAGGACTGGAAGGGTCTCCAGGCTCCTCATGGAGTGAATGGAGGAGGAGGAGGCTGCCCCAGCCCTGCCCTGTGTTTGCACCTTCTGGGTCCCCGAAGCTCAGCCCACCGTGGCCGGCCCAGCGCGTGGGCTTCACTCAAGAAGCAGCTGGAGGCACAGGGAAGGAGCTGAATAAATGCCTGGAAGCCT 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@rCer/2116/25_1627_CCS ATGGGCTTCTTCTCTTCGCCATCTCTTCTTTCCCGTGAATCCGTCGCCATGAAGGTGGAGCTGTGCAGTTTAGCGGGTACAAGATCTACCCGGACACGGAGGCGCTACGCCAGGACCGACGGAAGGTTTTCCAGTTTCTTAATGCAAATGCGAGTCGGCGTTCCTTCCAAGAGGAATCCTCGGCAGATAAACTGACTGTCCTCTACAGAAGGAAGCACAAAAAGGTCAGTCGGAAGAAATTCAAAAGAAAAGAACCGCCGAGCAGTCAAATTCCAGAGGCCATTACTGGTGCATCTCTTGCTGATATAATGGCCAAGAGGAATCAGAAACCTGAAGTTAGAAAGGCTCAACGAGAACAAGCTATCAGGGCTGCTAAGGAAGCAAAAAGGCTAAGCAAGCATCTAAAAAGACTGCAATGGCTGCTGCTAAGGCACCTACAAAGGCAGCACCTAAGCAAAAGATTGTGAAGCCTGTGAAAGTTTCAGCTCCCCGAGTTGGTGGAAACGCTAAACTGGCAGATTCGATTTTTAAATAAAGATTGCATTATAACTCTAGGTTGTGCTGGATTTTTTTTTTTTTTCTTGTAACAGGCATGTTGGATTTACATGGTCATAGGTGACCTAGTAAAGAATGTAAGACATAGGTATTTTATTAAAAAGTCTATTCCTCAGGAATAATGCATCCTATAAAGTAAGCCTTCCTTGGAGAGAGGTTAAGCAAAATGATGTAAGAAGATGGGTATGGTCAGATGCTACCTTTGCTTGGCTGGGGTGTATAGGGCACATTACAAAACTTCATTGCCTTAACTCTTTGGTTACAATGCTGTAAGTATTAGGATGTTGCTGGTGCAGGGGCCTACGCCTGTACCTGTAATCCAGCATTTGTAAGACCAAAGCCAGGTGATCACTTGAGCTCAGGAGTTCAAGACCAGCCTAAGTGACATGGCAAAAACCCCATCTCTACAAAACATACAAAGTGAGCCAGGTATGGTGGAGAGTGCATGTAGTTTCAGCTGGGAAGCTGGAGTGTGGAAAGTGGAGGATCACTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCTGAAATCATGCCACTGTACTCTAGCCTGGGTGACAACAAGACCCTGTATCAAAAAACCGAAAGATGTACTTTAAAAATGATTCTCTTGTTAAACTACCTTTTCCCATGATAGACAAATTTAGTTTATATTGGTTGCTTATAGTCATTGTTATCTCGCCCGGCCATAGGGAAACATGATTTTACACATATACTAGGTGAGGTATATAGTGAATGTCAATATTTTCCTCCATCCCTATCCTATCCAAGGTGATAGAATTTTTTTTTCTAGTGCATGTTAACATTCAGACGTCCAAGTGTTATGGGTAAAATGAGTAAGTCCTTTGAGAACATGAAAATGTAAACTAAATCAATATAAGAAATGGAAAATACAGGCTTTGCTCATAAAAGCAAAATGTTAAGATTTTGCATGGTTAAGAATCTTTTGTAATAATGTTATGTTTTATTTAGGAATTACTGGAAAATAAAGTCATTATACCAACTTGAATGTAAAGCTATGCTTGCTAATATTGGAGAATAAAATGGCCC 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GCGGAGGTGGATGCCAGTGTGGTGCGTGAGATCTGCTCCAAGTACATCTATGACCAGTGCCAGCGGTGGCTGGATATGGCCCATTGAGCAGCTCCCAGACTACAACCGGATCCGTAGCGGATGTTCTGGCTGCGCTTCTAGCGGGAAGCCTGTGTAAACAAGAGAGCTGGGCTGGGGCTCTGGTCCCCCACCACAAACACAGCACTCCGGCTCCTCTACCTGTGCCGCAGGTGACCACCAATAAAATTCTGC + *0<4703<2&AE:F%56A@HJ24?JGK@FA@HEFDIHJ5D8@AG7FGGCJG?DKH?>CDD/;EJJI?JGIDJ'=I7971CK'@HADHHIAAC>GJ4:JJIEBBG2C3A2GA@2G>8HH@%02-I.C@A,@D>AD:C)A<6$A>D-F@7F31B=>?HH>8AA)@-@?>$55%#;2<<<:;'76297=9(48>26C>BCJCF/6=<9?;99<39<>:9,19/6<6-=:275:8;,9,.)(%;799==6697:7794,:;427,-5=4876<81:39<>99;4::7?=;/=:033;7:8?:6<98=6>7:=6=>>8:588/9468::9918?834/0/:8:76=5<4:%:41;:<8<*<:60/,<;:48=3<2<2;<9<=3:6/62,96:2<:>=84<8/=>7;794?==:033)879>8421745=;-6)73:;25?>85=;3467<899=36=3.9*9,688807184586;8543<=70;9:=0<:7>:5=<<<;5<76647439>7<75)8;==;=;9/<5;89;?987+;3;77>><74;51%498<5958<7:97<56.68::8<86:32536*+1>57@99==@<>B>1==@>=A=A9?@:>?@9@9;A;;B?>:8@8;?A<=A6@A3;79,:28?A>>51;1<58?8?B@:>>=&*>=A7=A>A5@A<0>564=>?A:3A>8;?AA6A@?9;B(><>A.>@)9.@69>:3A;A<:6:=AA@5?=@95=7<;<86<5-<8@A@<;;;?,A=:0;2?8812;@?6;@?1;6?C;0@?7:7*:823?3A=>A70=>;<@2<==??6A6@>>@BA:=6:554;,4;=;8;.6=+>;;=5:>5:>=7:2<@)?88;;A?B2@B67:C89=@7=<5;>>4<=A;=;;>=*@>*4:74;:><<<<>69;=6A>/=669864;:?.+=<>=>7><>656@?;>9C<;'65=99)?A?@?B;>A:CA>?>>72?A??7@;:A>A4>.7==>?2<<:?;@AA6=A:A7<=@7=CCA<>7=?C>=A@CB9B>@;7838259?7B@BABC>?>?<>2=<@;;A=@@:=>;;4;A@9BB><@A59<888?<=/;:?<:60:@A>>:,=9ACA@CC=3=C?7A@,047>?>A@@1<6=>97+7@=965@A=B>>AB9@?6A@<:7<=3:2/@A3:B?AC=;B??/@>>=<1?:;8B>?;;9@>=C<;0=>A9@?>4ACC==/;<AA<;;FBDBCA7ACEFE@EE@GEBAAAGGBBDA>:;,=9:9>A>>??=9BDGE=9CE;GEC@EEDDE;09=AD:3@9339@=C=FDE;AGD+CB:9?GE6DDE=DED;DCFD==A:89@AD@G?;CB05ABFF=?@:>CCBCBD/A=FGGE7DBEB8BCB @rCer/2121/907_48_CCS CTGCCTGTGCCTGGACTTTGTGCCGGAAGCTTGCAGTCACGCAAACGTCTCTTCCAGTGAGCTCCTTCATTAATGTTTCTTGGAGGGAGCGCAGGTCCAGACATATTGTTTCAATTTACGAGTCCAATCGCCTCATGCCTCGAGCTGGATGACTGAAGGCAACCTGCTCCTGGACATGTATTTGGTCTCCCACGTCAGGACCTGTACACCCAGATTGGTCAACCGTGCCCTATCCAGTATTTCGTCCTACGTGTCAGCCACATGCATTAGATGGCGGCCGGCCTTTCACACCACAGTGGCTGCCCTGGAGGACGAGCTGACCAGCGTAATCCTGAGGGGCTGATCAGTGCCGGTGGACTCGCACAGCAGATCTCTTGCGATGGATCAGGCGCAGCCAATTGAGAGTCTCTGCTGATGGGCAAGAGTTCCGCGCCGCGCCAAGGCCAGATGGCTGCGGGAGCTGCGCATTCAGATCCCGCCGAGAGGGAGCAGGGGGGAGTGACTCCAGCCAAGCCAGTCTGGATGTGCACCATGTGAGGGTGGACGGTTGGTCCTCCAGGAATCTGCACCCCCTCCGATCTCCGACGGAACCTCCTGACCTCCACGGCGGCTCAGTGCCTGCAGCCGCTAAGAGGGCCTTGGCCATGGGTGCCCCCAGGCCTGCATGCCTTGTGGGGCTGGGAGGCAGGGCGGCTGCTAGGTGTGGCCTTTCTGTAAGGAGAGGCCTCAGAGCTCGACCCTGTGGGTTTCGTCCAGGTGAGACTGTTGCGGCACCCGCGAGCGGCCCCACTTCCAGGACCCTCCTGTTCCGCTTGTCAGAGTGCAGACAAGGGCGGTATCATTAAGAGCAGACTGAGTG + ')+(*,)()&'),#'&%"%"#%%('(('((*#%%))$&(%*)*%%$*(#($$$('**(+,&(++++''&'$"$*-*'+-(','*')'),*,)'+&.)...,*-/))$&%#&&''.$*,-*-.-,,*%'-.*-(+&,-("+'+,.-,-&/-*''#.&++*-&,&%--(&,-,-(&(-+.-%%'*-&,&*%'((,/).'&((%+,.&')-*+'./&,'(**-*)*-/,-'-&*++)%((+%,')(-'&'*$*.&,()*'%'%)&++#'#$''*+,$+-()+,((+/($*.+,++#(..,-)...'+)**(,-'-..*.*,..,,--/$&*),,)-%,+'(%),.*.,-,-.,+(++-)"*-%*,-&+),--)&/-,)&&%&-&-*,-++*&-.)"-(+,".'+.--,+&'"(,'',.-/+)*,((*+,(+&+)-)(,))'+(+.&*,'+)##'),,*,*&,-,('(+&)%$&$)&+$*#-+*/,.***$#*&*,'$'%*'.*,&',("%(+"(%,$%*.,--')#,)$)&##(,**+-(+'*-.)-,.'+#'$%%(,--'.'+,,,'("&($&%%&&+."-*,%+$.-.&*&.+,*"-.+.+(*+,%)'..(,---+(&'&)+$$+)'(*,'$+++%'(,+&/'+),,+''))%("'**"++*--)'+/(),$-,'(%%&(,&),+(*,*&(-/)-,+++'*',---**.%*(.,+$,,-&,*'+'+"&+,'",#().--,*-,+/+)-*+)*''&')%(("(-),,+$---*,.,*,'(,,+'##&(%)&*''-$&-$)'**(,,#--)-(('((%)."($)-.+,)-.&('$$*+(,+),.**.--%-.(,&(-(/-*, @rCer/2123/2262_57_CCS ATGGGGCCCCTCTCCTCTGGGTGGCCCCAGTGCGCGGGCTGACACTCATTCAACCGGGGAAGGTGAGGCGAGTGGAGGCTGGTGCGGAACTTGCCGCCGCCCCAGCAGCGCCGGCCGGCTAAGCCCAGGTCCGGGCAGACAAAAGAGGCCGCCCGCGTAGGAAGGCACGGCCGGCGGCGGCGGAGCGCAGTGATGGCTGGGCGAGGGGGCCGCGCGCTGCTGGCTCTGTGCGGGGCATTGGCTGCCTGCGGGTGGCTCCTGGGCGCCGAAGCCCAGGAGCCCGGGGCTCCCGCGGCCGGCATGAGGCGGCGCCGGCGGCTGCAGCAGGAGGACGGCATCTCCTTCGAGTACCACCGCTACCCCGAGCTGCGCGAGGCGCTCGTGTCCGTGTGGCTGCAGTGCACCGCCATCAGCAGGATTTACACGGTGGGGCGCAGCTTCGAGGGCCGGGAGCTCCTGGTCATCGAGCTATCCGACAACCCTGGCGTCCATGAGCCTGGTGAGCCTGAATTTAAATACATTGGGAATATGCATGGGAATGAGGCTGTTGGACGGGAACTGCTCATTTTCTTGGCACAGTACCTATGCAATGAATACCAGAAGGGGAACGAGACAATTGTCAACCTGATCCACAGTACCCGCATTCATATCATGCCTTCCCTGAACCCAGATGGCTTTGAGAAGGCAGCGTCTCAGCCTGGTGAACTCAAAGACTGGTTTGTGGGTCGAAGCAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTCTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACACGGAGTGGTAGTGCTCATGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCAGCCATGTCTAACCCCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAATGGTGGTGCTTGGTACAGTGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTCAAAGGATTTGTCCGAGATCTTCAAGGTAACCCAATTGCCAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGTTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAAGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGCTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTAATCATTTAAATATTAATCAACATTACTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTCATTTTTCCTACCTATATTACACAAAAAATATAGAAAAGATTTAAGTAATTTTGCCACCCTAGGCTTCAATGCAATATTCCTGGTATTATTTACAATGCAGAACTTTTTGGGTAATTCTAGCTTTTAAAAATTAGTGAAGTTCTTTTACTGTAACTGGTGACAATGTCACATAATGGATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGGCTTAAACAATTCAGTATAAATTGTCGTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGAAGAAAAGGTAAATGTTTACAAAGAGGTTTTATGAAAGGAATAAAAATTGACTTCTTGCTTGT + 9AC@9*@AA(8A@B<,6:DE;7>>A8<5A;,3@=;=<4BCFABA=A??6?CFA8C>CB@A=7>>/7=97&8>=5>A=@;E@FAABD1BA>DF=DAB9C;:?:BCA?E?EB>=?@8F=>@CC7=1AD7@FFEEDC3B:D<=C@;?<>4EB@BB?@?CEA;@7C@>/B<;=AAEF@BD>=9=@@:CABDF:?7E>DD:C>4629<,=B<4B;E@:C8A9<25:;96?6>@<1734:4::2=888;2,3-3)<:59C9BA>CAE>@=>8=9:/3:$-=>>C=A>@?6A?;=(51BCAA86?CB2B>7ED4DCBDCFEACEBEEAFDBAE@F??>=89:=5=@<;A:6@9B6:AAB8FD??;4;78;3?7;A@C91B6D::GAEDD>D@B8?9A<7><1CDBEG??C9C5?A>>2DA><;DD?EDD>D;=;=?>=;@B@>?E?BEB;9A?CBFAD?<@<5CDEC?0?8=88ACFB@D:A?7EE>D?=;77@AE3C4AADDD@DEC:CECGBAFCFCEE@BC:@@?D+AD=5)9?8@@>DEE>A@FECE@8;9A5C>:A?AG@?@<?FBC>EEG@@?E@B8>B?2CD=CBBBC>:CADC?=9ED>B86:BAAC>?A?;57::B6>?7B@DGCC@8BGCEC@BBFBC??.;@=81?8DEEA;>2=BF=@<?:A6C?A>DE@DB;9F?6@0;<=CBE08DB?E?C>D=@AD9?CEB=>CDEA5@7==A?D;DB61@DDC;64.5<;;/59EDFD.C@EB>:;@C7A1@EA7A6BC9BE6:>/E?>8C@DCA8AF>@>5:>FB?E>@+=F@??E5A3:>?1C?EF963A?<=,5@AA?8@>C?DD1?AE;=>@=F?E@@C?@<@EA7B?AB=B-B:;?C8B:8@EG?>C2>DAD4D9F@7D7>C@CD@A/BA>EBF8@@?:8<6D9CAFDE>CF<6AEBABA@;C68@:EE:7B?ABBA>FC@FC;D9?;CBDA<=B@=1AE>E?>)ECFDAD6B6:AB?A24A)A8GCECDE>EDD?=.?5D=F>E>A7D<==@4>077;=@8A;8@7??=:>C>A=?>2A:>A5?7B<9C<;@?<=AA5>>0@@@65:+6=99?:=A;AA?C=:@9C>B;B;@?>7@@<:?7>C=;CA??C7;<:7=2317>=14<1>>=9>=4::==?896=?=:?=:=:492;8::/;?<<8>9>8<;2<>=:==6<=::?7;<<+:=4/;9=>=<=/>6,;7:799'<99268<=:>=5;<3;?<===9=<;7;<9=259788<75>=990<3/7:;79==;8><>>1:=><=:)787==:<.=:9:=45=69>=:=>==8;:4/37%?<7::=?8?=982>7?;==:083?=>;:1:=;/;=;?=;,?=>:9826-6-%;=86.====?;5>7=>=;8:;>:9<;798<=:<03796===?2>=8?;?>=:?=;<=,>=85=:9665-;=/>=7>;;<499?7:89;===?6;=<65==:;::3;729;<;9/8=;7>:?;;7%<3:=95;8;<+=71<=><9<9/0=>:+5>:<:?>=9?:==;:?:<>>7;9*9:37<9<<=379=1<;:;-71;:>=;98;<>?==<;<<0;>:2;><=98757898<2>8;?>??9>>9?7>;=>:5:62=782<8;;:;;%867=9==9<=:=3;<7:$044=??2?8<=:3>>>;.5;:8,:9=<=;/2):/&<>??3>68=7?<8=47;9142 @rCer/2125/1773_58_CCS ATGGGGGGTGTCCGAGGCGGCTGCGGCGGCGGCAGCATGGCAGGGCGGCGAGTTAACGTGAACGTGGGCGTGCTGGGCCACATCGACAGCGGCAAGACGGCGCTGGCGCGGGCGCTAAGCACCACAGCCTCCACTGCCGCCTTTGACAAGCAGCCGCAGAGCCGCGAGCGCGGCATCACGCTAGACCTGGGCTTCTCCTGCTTCTCGGTGCCGCTGCCGCGCGCCTGCGGTCGTCTTTGCCCGAGTTCCAGGCAGCGCCCGAGCCGAGCCCGAGGCCGGCGAGCCACTGCTTCAGGTCACGCTGGTCGACTGCCCGGGCACGCCTCCCTCATCCGGACCATCATCGGCGGTGGTGAAGAAGTGAAGTCCATGCAGATGTTTCACATGCCCATCACTTCAGCCATGCAAGGAGACCGGCTGGCATCTGCGTCACCCAGTTTGACCCAAGCTGCTGGAGCGCGGTTGGTGTGTGCCCCTGAGTCCCTGCATACTGTCCATGCGGCCTCATCTCTGTGGAAAAGATACCATATTTCCGGGGCCCCTGCAAACCAAGGCCAAGTTCCACATTACAGTGGGCCATGAAACAGTCATGGGCCGGTTGATGTTCTTCAGCCCTGCTCCAGATAACTTTGACCAGGAGCCTATACTGACTCTTTCGACTTCTCTCAAGAATACCTCTTCCAGGAGCAGTACCTATCCAAGGATTTGGCACCAGCAGTGACAAACAATGATGAGGCCGACAAGAAGGCCGGCCAGGCCACAGAGGGCCATTGTCCTCGGCAGCAGTGGGCCTGGTGGAGTTTGAGAAGCCTGTCACCTGCCCTCGGCTGTGCTGGTGATTGGCTCCAGGCTAGATGCGGACATTCACACCAACACGTGCCGGCTAGCCTTCCATGGCATCCTGCTCCATGGGCTGGAGGACAGGAACTATGCTGACAGCTTCCTGCCCAGGCTGAAGGTGTACAAGCTGAAGCACAAGCATGGCCTCGTGGAGCGGGCGATGGATGACTACAGTGTGATCGGCCGCTCCCTGTTTAAAAAGGAGACCAACATCCAGCTCTTCGTGGGCTCAAGGTGCACCTGTCCACTGGAGAACTGGGCGTCATCGACAGTGCCTTTGGCCAGAGCGCAAGTTCAAGATCCACATCCCAGGTGGCCTCAGCCCTGAGTCCAAGAAGATCCTGACACCCGCCCTCAAGAAGCGGGCCCGGGCCGGCCGCGGGGAGGCTACCAGGCAGGAGGAGAGCGCTGAGCGGAGCGAGCCCTTACAGCATGTAGCACTCAGCCTGACTTTCAAGCGTTACGTCTTCGACACCCACAAGCGCATGGTCCAGTCTCCCTGAGTGTCCAGTGACCTCCCCAGGGCCTCCTTGCCCGGCCCAGTCCAGGGTGCTGTGCCAAATCCCAACCAGTCATGCTTCAACCTCTCCCAGTCTCTCCCTGCAGTCCTGCAGCAGCAGCCCCCACCCCCAGGATTGGTGCTCAGCCCTGGTGAGGAGCTGAGGGGATGTGTTGCTGGGCCAGGAGGGTCTGTCCTCCAGCCCCTGCACACTCCCACCCAGGACAGCCACCAGCCCAACTAGGAAAGGCCTTGGGCAGAGGGCTGGTAGCCAGTGTCTTCCACTGCCCCATTTGTTGGCCACCTGCAGGCCTGTCTCACCCCTCCCCCAGGTGGGCAGACACTTGACGGCTACAAATAAATGTCCCATGGCCCC + BGGBJJH0BJJKKKKK0KKHKDKKK?EK>EKGKDKKIJK@JKKG6JKEKK9HJJJKJKKKIIFKIIB.C@JIIJKJ-H1JIKJIIJKFKJK4KKJKKJK?JCIJFJKJEBG9KKKKKIHIJKJ?KEEKICK@KKJKK:?K@KKCKIKK=I=IHEEGB?KKKKCJKKKKKKJK*IJKIDIJG?JJIKDKJK6JKCJJG$IKBKAKJEKEJEK,EKHJK+JJIBKKDKKKKIJHKAHGK8HKG-DCDKGKKGK;IEKJKKK5IG&13IEKKG9IHK.KKKCIFGJKHKJBIHK@KJG+AKIJIGDKHIKKHJJKKJ'-K)JJJHK9EBI.FKKKK4K0HKAJJKKGJJ(KJ9?K;FKKEHK7*CCGF:JJ?HGDKKKIKJKJ:>GFGHKKGAJHIGHKK2IIE)JJHHAHKIC;CAD5GJJKCF+AJ,KGJEGIJKH=HJHJCJ$FDH;KKCJKKJJJ&FGGHKKJ@IHKJKKKHJJF:<9JJ@KIGEKHK=JIHKKKDKKHKGKJGIJKK/ICI@IKEDKEHHIKKKK?K>ICKIKF:KKGJKBIJHKG4KJE?KKKKCBKKHGK.KKK8JI:GGK-CJHKJJ$EGIJKKGKKKIIAKKJKKKBKJCHCB*C>K;K3HK:KA(K*B<&HKCAJKJ;JFBK>AK9GIHHIK9JJKK3JJK.KJKJD&8J7HDHG:K:KJJ0JG+HFGIDFJKKJKKKKHKFHDIBK-KKDCJIKGJ;KKIGK8K7K;KKJ>II>KJKKIJK@KJKK=IKKJKKAKGKKKKHKIFIKKKJJKKHBJGKIJKIE&KKGGFJKGJGJKKAJCKKKIKJJGEKKIIAI5FJIDKKKHKKHIKJ*IFGGIFDK;KKKBKKK>JHG@CEEEFHAJI4IGJHIBHG4K>BKKIIIJHKKJJJHBKGKKGKKKJKKHJKDKKJDFGHKIKKHJJIIDBI*KIKKHJIDAJJ1?C;JKGJIBI:JKKKKJDK?GFHJKGD;GKJ%DDJ5K8JK>KJKKKIFKK9IKIJF>IBE@CD*GJ3GCB%K3HFGHJKK?KJ>JJGIFE$HCEEEGCJKFC>-:?BC=D>A%>HIFHG1GKGHGKKE&CD?IDCG/=K1JKK+JIEBKFDK0;A)CBFH*KGJHJK0KD9K)?EKAKK?KJFGKI8JCJA?@@I?IIIFI=G2K?KCIHE=>/JHKHHF9J@HCJI@K@JHK@K9IFGBD>HKJK0IKKKK+FK?KKK:EFEGG?EJIH-II9FCCKHGAJJK;DGA:K)CFKHKJK. @rCer/2126/1905_59_CCS CTGTGAGAAGACCTTCAGGGACAAAAATACACTTAAAGATCACATGAGGAAAAAACAGCATCGTAAGATTAATCCTAAGAACAGAGAATATGACCGATTTTATGTCATCAATTATTTGGAACTTGGAAAATCATGGGAAGAAGTTCAGTTGGAAGACGATCGGGAGTTGCTGGACCATCAGGAAGACGACTGGTCTGATTGGGAAGAACACCCTGCCTCTGCCGTCTGCTTGTTTTGTGAAAAGCAAGCAGAAACAATTGAGAAATTGTATGTCCACATGGAGGATGCACACGAATTTGATCTTCTCAAGATAAAGTCAGAACTTGGATTAAATTTCTATCAGCAAGTGAAACTGGTCAATTTTATTCGGAGGCAAGTTCACCAATGCAGGTGTTATGGCTGCCATGTGAAGTTCAAATCCAAAGCAGACTTAAGAACTCACATGGAAGAAACTAAACACACTTCGCTGCTCCCTGATAGAAAGACGTGGGATCAACTGGAGTATTATTTTCCAACCTATGAAAATGACACTCTCCTGTGTACACTATCTGACAGTGAAAGTGACCTGACAGCTCAGGAACAAAATGAAAATGTTCCCATCATCAGTGAAGATACATCTAAACTGTATGCCTTGAAACAAAGCAGTATTTTGAACCAGTTGCTACTACAAGAGTGCTTGAAAAACTAGAAGAAACTACCACAGAAGCAATTTTTCATGTTTTTCTCCTATGAGACGACATGAAAGAATAATTTAAATTTGAACATCAGCGAAGGATTAGTCCTTGGTGAAATAAACTTTTCAAAAAATAAAGTAGGAAAATGCACTTACTAAGAACATGAAAAAAAATGAAGTAGGAAAATAAGATGAAGACTTTGTATTTTGGCTATCAAGTTTTATTGTATGATCATCTTAAATGAGCTCATTTCATGAAACTCATAATTATCTATAGAAGGATATGCCAATTACAAAGAAATGAAAAGTTCATATTATTTATAAACCTGATTTTTCTATCAGTAGTTTCAGTCTCCTCCCCAAGGACCTTCTTCATCCAACAAGTTACAAAATTTCAATGTCCTTTCTGTACTATGTTGGGTGACCTGTAAATGTAATGACCAAAAGAAAAGCCACAGAATAAAGAAGAAATGGTCAAAGACCTGGATAATATGCAAATTGGCCATTATATTAGAACAATCAAGAGCTGACTGTATTATCATTACCGCTTTCTGCCTAGGGTGGCCAAATTCTCTAGAAATAGACATCAAGCCAGTTAACTTCACTTTTCCCTGCAATGTGTCTATCACTAACATTTAAACACTATTTTTTAAAGACATAACCACAATACCATTATGACACCTAAAAAAAAATGAACATTAACTTAATATCATCTGTTTTCAGTTTTTCCCACTTGTCTCAAAATGTGTATTTACAATATTATCAATTTCATTACTGATAAATATTGTGTGCCTCCTGATAAGATGCACTGAGGAGGGCAGAATATCACTTTTGTAGATTTATACCAAAAATGCATATCTTGGATATAATGAAGAAACAGTCAAATCCAAGTTTGAGTGGTATGATAGCTCATATCTGTAATCCCAGCACTTTGGGAGGTCAAGGCGGAGGATCACCTGAGGTCAGGGGTTCAAGATCAGCCTGGCCAACATGGCAAAACCCCATCTCTACCAAAAAATACACAGATTAGCCAGGCATGGTGGCACGCACCTATAGTCCCAGCTACTCAAGAGGCTGAAGCACAAGAATCGCTTGAATCCAAGAGGCAAAAGTTGCAGTGAGCTGAGATCGCACCACTGCAGTTCAGCCTGGGCAACAGACCGAGACTCTGTC + KKKKHFAI9JKKGKFIHJI=IHKKKJ?JIJIIJCJKFJGF@JJGHG?KJKKKKK7A9JKEEJGIKDKBJKK?IDKJKJ1J1DJ@FKDJFKKCKIKJKKKJJGKKI@KKKIKIHKFIKBFKKHKDKGHKJKJKJK=KKKKIKJJH7KDIKGKFKKHIIK=KKIJKKKGIJKKKCKKKKAGKJKKKBJJJCKIJJKK?JKKKFJHKJK>KKGEKKKKKJIKJKKKKKKKKJHHKFHJKBJKGKK=HJKJIGJDJIJKK=KKKJHJ@AJIKJJK?KKDKHCI=EKKFJKKJJ6IDKCJKKJKEKIJKK0EKHJGIKKIKKIKIDKKJIK8KKKKKHJIKHKKKKJFIKJKKJKKKJHKCFKK>KKKKKCKHJJHJKIKFIKACJEJKKKKHKJKKK@KJKG9KHHJHJJKKFFHJJIK9G5H?KJKHKGEFKK?JKKK@KHFEFB3DKIG5AIJH>ECHIGJFFDHGG>:GBKFEJGA?HDKK8J@GAKJKK?DIK=HDGGD:JKGIGIEGCGHIDHHIG6JFJKGJJJH5G>EIDKIKH?IK;KEKKKIKIFFFK6JHKJKJCJGFI>IEAI>KHHD@CH5CI@JJ4DH?GK@KJ>KHICK@KIHIJJJK@I?IFIGJHD>EIJ@HHDHA8GGKGHKDFCJJ2G@JJDIHHKHDJKI=K?IJHEJI7HBKJJKBFKFIHDBFGGDGIF?JFE=FBDKKFCHGHHI>DKIJIIH3@@?CEEF9GEFHIKJHG>EHIJKKCHJFKHCHIJDFEED@DAF=GIIE?GH:GGGFHIJIJIFHEBIHHFBHH9DH?GE?IJKHIEKKIHJEGIEJIJ?FGD?JKGJJA/IEIHGJJKJJGKIGKGJGKIJGKKIIJI<-KKKAJEIIIFF=5EEGJJ.JFIHBEAFJIGAHKJIIHK?J@??G6GIIIKI@HDHIHHKEK8KIKCIJDD4CD,IHAIIKJJJJHFKIBG>E@DAAHJII@JKGIEGEHKIE<='????=::::?;DBC@>AE=<=;=<8>;89AEB=:$8<2?;@C=E>@F:?4D;=9A9$8@B:;;B;@?@?B>@@@F@F?EB7B7?A;EEDDGC@EBBFF=878ACFE2?AE@EA>D@EEE@FBDE@F?;EB@ADCDDE><6=;;?;2<:?=>@9:=843-::86==8A@BA>E>CAB256C3=@EA?@<05A(<>CCE@?:)@3@=AF=9>B?:@8@?;0EED?AAAGFA?;C@E>?E?=??CE3A@?48@D?83>A>;8?C<2?7>A0AB*B?78;?;>@@>>;>0</;??B?4=?<11@A;0);64;1GB>;4@E==>?CE9E@?8=>2=B5E>@D;>>C<<>7EDA@A8DDD>4BCCDGF??CB@?@E>@>69296'8=9;@C>>BC3DE@FED@92<3AAFDF63,20:?887B@EC90;88=A;@EA?BD:B=?@EF=A=?::C65BA@F>F=A=BDD@BE;AFE4EA=9AECDGC?E?AC9>7DA;E?>DEFDFE3A?B>F@EE2D@BBFGED@BF@7A??;A=@>8AFAC@GE@G=GE?GCBD??1:9==3>@?B7FDF6DFEEEF;B>E>@EDEA/A?CBCEB:BA>B7A@EGAAD5D@;;@:?6=BB?B>D?BE8@:7CEAA@FCB5CG@@@;8ECA9A>:9E@?C>BAFC@ABBEE+9CDEC;@ACA@97=6?C9BAE79AAEED.@EEC>4BA>C?6:@6<;;;0ACB8=A3>1AAC>A=F??95=;??BEE@FFE=CB>BABFE@A?;:DF>;CA;?GDCCGA8@<8>EE>DA@CFFCDG9AEFBEEE:FADF@?IIFEFBH=GABDEGDCC?DCIE>>EAF8B;89EID)DFF>C>I29D%C?CI?C>@IAHIDJIIEDGGGFF=1CCGHEHCHCJ3JJE8GII5E=EII>?BFFJHI?AEEII=J;1DFIHIFGHFAAJHGICHCIC6EIFJ?IIFHDHI:EIFFIIGJ7GHHFBFG5JI7HJHJ7CBIIIHICIG>GIHHIFIFIIJHF?G@HHB7IGGIB>DG>IHHBDGI@I>G>HI1HEGHEHIDHG=>DG@J7GA@G?FI;GI:CIIFFA?IFFIJHAH;EFH>CIBGEGEEGFHAF6HHDIGG4EE;BG?:EEHCAIFDDGBG?HHBE@EHBBEEHDGDEG5GH:E??GBCJ@E@FIFCIF9@7D:6:C>@A+AFFBB8FH=DE8=:/>@HD>@F8E8IF>BHFFJD@>CB/EGD??C3?C;D@F??C.?>;CDE7H>,CFIB=IFHII8C>CFD7CC7;B@:CD@C@E=7@HFEGHIE;EGHEDIICACCEH>IF?EECGEI4@>?DHEHFDAI/GA;KKFFDJ;GEG>GCHD>FCKEGC(KH62H<-F3EHJHK@>GG=IEKJ?KHGJAK@K?HI>?IFJJJCHJIGHGHJKIICJJGE0FHJCIJIK:KJE6IHHIG>C;@5D>61FHFHB8I4JIG=C5FGDII?@FD;JF?HE?FF=FFD:GI=JE?HAEE4IE?E7@6@D@C@FIFCI7A@BDAIE;FIDJ2JHD7>2DFDIFF?FEAE>E=GE=D?A+=;B;=DFE?EAC0>BEEFCE @rCer/2132/0_2148_CCS CCAGATCGGGCCAAGTTTTGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGTGACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCACAGAGGGAATTATGTCCCCAGAGCGGTGCTGGTTGGACCTGGAACCCGGCACCAATGGACTCTGTCCGTTCCGGCCCCTTCGGTCAGATCTTTCGGCCCGACAACTTTGGTGTTTGGCCAATCCGGAGCCGGCAACAACTGGCAAAAGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCCGTCCTGATGTAGTCCGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGAGGTGGCACGGGGTCTGGGGATGGGCACGCTGCTCATTAGTAAGATCCGCGAGGAGTTCCCGGACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCGGATACGGTGGTGGAGCCCTACAACGCCACGCTGTCCGTGCACCAGCTGGTGGAGAATACGGGATGAGACCTACTGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGACACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTGCGCTTCCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCAGTCAACATGGTCCCCTTTCCTCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCCCTGACCAGCGGGGCAGCCAGCAGTACCGGGGCCCTGACGGTGCCTGAGCTCACCCAGCAGATGTTCGACGCCAAGAACATGAATGGCGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACCAGCAGCTACTTCGTGGAGTGGATCCCAACAACGTGAAAGACGGCTGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGGCTGCAACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGATCTGGTATCTGAGTACCAGCAGTACCAGGATGCCACTGCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAGGAGAGGTGGCCTAGGCTGCTCCCATCGCTTCCCATCTTTCCCCTTGAGGCTTCTGACCTTTGAACCCCTAGGCCCCCCATCTCTGACCCCTGGAGCCCACTTTCCCTCCAAGCCTGACTCCCTGCAACCGTAAAGACTTGGCCCTGACCCTAACAATACCTTTGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCAACCCTGGCTCCCCTTTGACCCTTGAGCCCCAATTTATCTTTGACCCTCTTGAGCTCTTCCAACCTTGACATTCCCAGGAGGAGCCCCGCTTCACCCTTCTGACTCTGGGAACGCGCCTTTAACTTTGCGGTCCTCCTTCACCCCTGACCTCTGCTTTCACCTTTGACCCCTGCTCCCCCCATGAATCCCATTTTACCTCTAGACCTAGAAGTTCTGGTTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCTCTGACCTTGCTCACCTTTAACCCCATCACCTGAGCCCCAGCTCCTACCTCTGACCTCAACTTCTCTTTGACCTCTGAATCCCCTCTGACCCCAACTTCTCTTTCACCCCCATGAGTCCATTTTACCTCTACACCTGTAAGTCCTGGTTTGCACTGGACCCCTCCTCTGAGCTGCAGTTCACCTTTGAACTTGCCTCACCTTCACTCCCACAGCCCCAGCTCCTACCTCTGACCCCTGCTTCTTCCTGGCTCCCACAGGCCCCATATGGTCCTCCCTGCCTCACTCCCCTCAGCCCTGCCGACCTTAGCTTAATCTGGGAGAGAACACAAGGCCGGTTTTCCTGTGAGGAGGAGAGGTTGCCCTGCCCTCCCTTCCCGCATCCCTGCCTTGCCTCAATAAATAAATTGATTGTTGTCCTG + S""$#"#$%#$%%%&&%()"''&$&&('(,+)++&)((,,,%'-+---*+#*($%((&((%%))'%''$"%&(())(&'##$())')%$(()('$$(&(')&(&())($$&&)))($%#%&'""$%$&()))())())&%$$'&))$''%%'%),-'&++#$%%'(+$'&%)-$&&(-',()(+"&,+-,+)()#'&&&)'#&%%'%('()))(&)%$#(%%%'('))""$'$%($$%(&(%$(()%&')())&)'$%#&%'&&)('%&(%%'&((%%&%%(($&('))))($%%'))))()()()'$$'$&%')')))))('#'())((%##&%&))()''&)%((%$&)'&)#'')')(%'())(%()'($$%(')'$(('(&')(&($#%'&&(%((()))(%((&($#&&(($)((&'(%(()()('#''))%((&)()(('&$'()(''&(())&$((#%$&%((('(&(''))((%((%&%%('()(%(($&%%$'&&('')(&&&%'$#&((%$$%'(($'((&)(&(()'%#'&(%$$#((%$$'&$%()')('%(($#$)(&(#''(%$#$'(#'&))&))'(($'''(#&&'(%(()))($$''()(&()$$'%')(&()'%()))(%&%))($$(%(('%()())($'')&'('&')%')(%%'('$$'&)$%%'&))')&($&$%(#'%'((,*+(*---.,*-+.-),,-+.-,'',,(----..-.,('&),*----*,$*+((*+,-+.--*--,-+.-,,-+,'-*#'*'),(,(+'+,%'*))*$(**(-,(---+-'(*-((,-,---(,)((+,)+(+&,,-+,((((-,)-,,('$*+&$#),'*--*,-..--,(-,,)-),-+)(,*-*--.**+.)-,$'((+)-,-$)'&&-+&*-(),.-)&-.)-,)*-,-()-+-)((**(,(+*-,,&(((&(*-,-)&)$)&&*()*'))'+),,(((+*''&)$**%,,*,,%+(%+*++-+.--)------,--,'++,,-..-*'-'-*,))*)-),)(&(,-())-,,&*),*-.-*),),*.-.-,)*++.(-,,*(,+(-)*-(*)(%$*+),+#)+.-',),(,*+)))-.+#,--,-'-,.(,'**-',*(*-'+(*'',*'*,'++(-*#)(*+-+)%,--)+,,,%,,)-'*(+(+--,.,---%%*-+----.,,+()+&',-)('*$$((&*+'&')&((),)+'#')(%+,-.--+(*.-,+#$**.+,.,('+-.+#)+-**-,-&#%*+-),((-----*)(+'--&)*)-,'*-,&,*$*-)',(,*$$%%'')#$&*,-)*%+&,,,,+*+(+$+,('-,('*'(+$**%'&(%'+.-,-&)--,-+#&&%),,-,&,(,,+#''(,+&((+*-*&&&#%))(,(,,+$"#'*--.---*,-**-*,),,-)+.)())+--)')(((+*(-*++.+))--+&,+%&+-,*,+#))$*++-*--'&(**+**$(('"$)-+#*(+&*(,*.,-*.-,,&(+%+()+.,),)+(,----*-%'('+*+*--'()'((-,(--+--,-'-*,.)),+&%$,(++*&(&&#$'&''''%$&%$((+$'%$&##$'''&%&''&$$$$&%$%%&$''')#%$)&$)-(+-%'(++-,*(+-*.,',)('(*--)'''-,)'(---,)-),(),----,'*''++,*,-,)+$"$')+$)-,(*--)*-&++,----(()((,,...--,+&(*-,-)---%(,+-(,--.,(+$***--.*-'*,-%$('$%&#%$#'&&%&)()(&($%%(($((('(&((&'$('&'&(()))))))(%)('#&(('#$%(&%)(#(%$'()($%%%$#&')))&(()('%'%((((&#%%'')(%''()'('$&&(#'''%()&$$'()&(%(&(&)'(%('('(%%('(&%(%)%$%()((')(%(((&(&$$))(#%&((%'&&(%&((($'')()(#((((&('$'&'(&)((%)$''%'()$#''%'))'%(($&#'$()')')#($'&%$$&()(&%((()&(&%)()(#&&$$%$&'%((()())'('&())#'%'()(#)'%%(((&)('&(&()'#%&&'&(%'(% @rCer/2134/25_1493_CCS ATGGGAGAGTCGGGCAGACCGCAGCGGGAGCGGCGGCGTCTCCTCGCCCTTTCTCCCTCCCGGGCCTGGGCGCCCAGCCCGACAGGTATGGCGCTCACAGTGGATGTGGCCGGGCCAGCGCCCTGGGGCTTCCGTATCACAGGGGGCAGGGATTTCCACACGCCCATCATGGTGACCAAGGTGGCTGAGCGGGGCAAAGCCAAGGACGCTGACCTCCGGCCTGGAGACATAATCGTAGCCATCAATGGGGAAAGCGCGGAGGGCATGCTGCATGCCGAGGCCCAGAGCAAGATCCGCCAGAGCCCCTCGCCTCTGCGGCTGCAGCTGGACCGGTCTCAGGCTGCATCTCCAGGGCAGACCAATGGGGACAGCTCCTTGGAAGTGCTGGCGACTCGCTTCCAGGGCTCCGTGAGGACACACACTGAGAGTCATTCCTCCCTAAGGTCCTCCTACTCCAGCCCAACCTCCCTCAGCCCGAGGGCTGGCAGCCCCTTCTCACCACCACCCTTCAGTAGCCCCCTCGCTGGAGAGGCGGCCATCAGCCGCAGTTTCCAGAGTCTGGCGTGTTCCCCGGGCCTCCCTGCTGCTGACCGCCTGTCCTACTCAGGCCGCCCCGGAAGCCGACAGCGTGGACTCGGAAGGGGGAAGCCTCCTCTTGGACGAGGACTCGGAAGTCTTCAAGATGCTCCAGGAAAATCGCGAGGGTCGGGCGGCCCCCCGACAGTCCAGCTCCTTTCGGCTCTTGCAGGAAGCCCTGGAGGCTGAGGAGAGAGGTGGCACGCCAGCCTTCCTGCCCAGCTCACTGAGCCCCCAGTCCTCCCTGCCCGCCTCCAGGGCCCTGGCCACCCCTCCCAAAGCTCCACACTTGTGAGAAGTGCAGTACCAGCATCGCGAACCAGGCTGTGCGCATCCAGGAGGGCCGGTATCGCCACCCCGGCTGCTACACCTGCGCCGACTGTGGGCTGAACCTGAAGATGCGCGGGCACTTCTGGGTGGGTGATGAGCTGTACTGTGAGAAGCATGCCCGCCAGCGCTACTCCGCACCTGCCACCCTCAGCTCTCGGGCTTGAGCCCACCATGCCCTCAGCCTGCCTCCCTGCTGGGCCAGGGTCATGCCTATATAAGCTGGCATGGCAGGGACAATGGTGGGCAGTTGCTCTTACATGAGCTAAGTTTGGAGACCTGAGGCCCCTTTGTCCTCACTGGGTGGGCCAAGGTCTGGGACCTGTGTTGGACTGTGGGAGTCTCACCCTCACCTTGCCAGGCCTCTCCCCTGCAGGACTGGTACTGCACTAGTCTGAGGTGGCCACTGCCTTTGATGAACCTTTGTGTGCCAGGGTCTAAGTAGGGTCGAACACAGAAGTGGGAAGGAGAGAGGTGGGCCAGGGGCTAATGGTGTCACTGTGTAAAGTTTTTGACTTATGAGCTGTATAAATATATGAATACGGACAAAATAAAGTGGACGTCC + 458?C<@>=45279>7<84925395)1143::>>:<@6::;559474A=4>A=>6>A77<94>;7=?1?>A@4:@;;3?=9;05+66.:23.59;8108==8724=;>956'4837;9837/=800;;2>344-20-:93&-(033;33=5=8:95<28:6/6,=<>;7-8:9?6<)4435706)363323406234;1:7<5:709=4-4548:50=<2=;90;:9<;74<67:9;>8+23:8245/6,33=5<;<9:8;,68881=:39;==<(32888=9=9=88<;?=93;;<1<9==/=01644762:30=;76<67;:0=<;9:<378?:'<<;;=<5528>9<9?4::98:7;;;78=;=6:>?9<.1:89;:<;67=4?;<:;;45*/6879:8==79395,6:66;3:7;9342-:5.1;<9;=>0=77941;696=:<=<=7?9;:4=><6/8=8.;7:5,528.;9,776;958<9:6=<:=;=8754834687;4>88>>69;4<63;:6:<;<;:788156<:=:9(;'86609;8<:/75695;66)09.673;2:75;*3758/:<5=8+;651828=9;745-17478=<<:<9;3=):<;98?97:18=>:790;7<=:4?<;992=::;647;:;=5=88;:4683;.<<<8;;<828>=780<995<&3433.699:8:0<;:81=?;;<76<7<>7><637;.;87=><9<73;<=6=<9/;69=8;9<=2626'9589;7=;=9<7?:==:281<49:<7?=<=><56::<8=7;6=956=+9751:<-8:>;?(67(034.&-.%4473/461185297403+3/-1889>99?:==:==;6=>;<99>=<>;=6.<;664474;>8.=<88;;;=>:7:508&17=<=<6=<=>;=:-:5<946=<<>8951,87<;=8866:;2=;93==<96<==8769;+94:>>9>6=;82<9;;698?=>9=;7=<5173718<978;>=3;9'3.1259;=;76(933.889;,:<.8;668(9;<==>9>5=57/74;789/.5:8:>275*38::13%)6:9<<=<<-><789;9:29:<83=78<52;=856:;:;<>6<<:>>>6;;=6>6:78:&746.>?8:3=.=?<<7;<;>9>=>=;9??89825;>49:=7:(;4;;5;>;?4?;295?==9<=7757687>9>>942<8<:;>>;>>==:>>58629<9=2==66>=(88?2:=57;794<38><9677==;815<:<>9=>=:'85<:93<;69257:389483.:438<3?;=:48::<=<:;==>:63<8<2=<;<9=:/:;;;8:==<418-535;:3-;99;,48><><9?:395?;=2>9:<>3; @rCer/2137/2199_52_CCS ATGGGACACACACACTCTTGGAGAGAGAGCGCGAGGCAGGGAGATCATCTCCTCCTCCTTTTTCCAAGGCTGCACTTCTTGGAAGTGAAGCCGGTTTGGGTTTTGTTTCCCTTCCCCCTCCTCCCTCCTCTTCCTCCACCCCTTTCCCTCCCCCCTCCCTCCCCCAATCCCCCCTCCCCCCCAAGCTGTCTTTCTAGCATGTTGCCCTTTTTCAACCACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAAGATTCTCAAAATGGTTTATTACCCAGAACGCTTTGTCTGGGTCAGTCAAGAACCATTTCCAAACAAGAACATGGAGGGAAGGCTTCCTAAGGGAAGACTTCCTGTCCCAAAGGAAGTGAACCGCAAGAAGAACGATGAGACAAACGCTGCCTCCCTGACTCCACTGGGCAGCAGTGAACTCCGCTCCCCAAGAATCAGTTACCTCCACTTTTTTTAATCGTAACACCTCCATTTGTATTACATATGGTGTATGGGTATTGATGAGGTCATGGTATCATATATGGGATTTTTTTCTGTGTAAATCATCAAGTATAAGAAGAAACTATGGGACTCTGAGCCTTGCTTTAGAGAATTTACAGTGGACAAATAGGTATCATCAAACCAGTTTTTAATCATTCTGACTCAAGTGAAAACGCTCAGAATTTCACACTGTGAATCCACGTTTACAACCCTTACAGGTGGGCCTTCAGGCCTGGTTCGCTACAACAATGTCTTCCACAACTCAAACTCCCACCGCGCTCACACAACCGGTCCACTCCTGCCTTTTCACTCACACAGCTCCCGACTGCTTCTTGCAGAGGCTGAGAGTCCCCCTTTTTTTTTTTCATTTAGATGTAACAAACCTAGTAGTTTATGTTCATCAATTGTCTGTATATCTCTATATTTTATCCATGTACTCTTTTGATGTATAGAAGTAGTTTGAAACTCATTGTTTCCTTGTGGTAAGTGACCGAGATGCTGCCACAGGACCTGAGACACTGATGAATGGTGCTATTTTGGACTTTCAACATGCTCCTTGGCGAGGTAGCTCTGATGGAGTTATTTTTTATTTCCATGTTCTAAGAAGGTGTTGGTACTCTGTTTCCCTGAATGTTGTTCTCTAGACTGGATTGACTTGTATTCCTTGTGTCTTCAGTGTGGCTTTCTTCCTCAGTGTTGTAGGTTGAGCGAATGCTACCAGAGTGTGAGAGACAACTGTCTCGTTGACTGGCACTCACGGACATGCAGTCACGGTAGCGGGAGCAATCACAAAACTGTAATTTACTTACCAAATCTCTTCCTTTCCGTAGCCTCGCCTGCCTGACTTAGAGAAAGAAAAGCAATAATTTTACAGGCATTTTGAGGTGTCTCTTTGGGTTCTTTCTGTTTGAAAGGATACTTGTGGAAAAAAAGAGCAAAACCTTTTTAAATAAATTCCCCCTGAAAAAAAACCCCAAAACACTGGCATCTGAGTAGGAATATGAAAATGACACCTTTTCCAAATATTAAATTGGAAAGCAATGTCTTTACAAAATCATAATGCTTTTTTAAAAGGCAGAGCACTCTTTTTTTGGCAATTTTGATAAGCAAGGTGTAGATTTACATTTTTGTCCTTGCTCCCAACGAAATGGATAAACAAAAATAAAATACCATCTACTCATGGAATGTTGTTGTGTTAGCCAGTCTGAAAGCCCACCTTAATTTTTATATAACTGTCTTTTAGCTCTTCTTTTGACAGGGCAGGCCTTGTTCTGAACTGTTTCGCTTCTGACTGTTAAACACCGATGACGCATGCACTGCACTTCTTCGTTTTCTTCTTGCTCCCCCATTGGCCTGAGTTTCTTGTGCATTCCTCCTCTCCCTCCTTCGTTAGAATAGGTATATCAGCTGTGTAAATAGAGCAAGAAAACAGTATTCTGCATCTGTGGCATTTATGTAGAGTTGCAGTTGTGTACTGCTGAAAATGCAGGCTTTTGTAACAATGTGATCTTTACTGATGCACTCATGACAAGTACCCAATGTATTTTTAGCTATTTTAGTAGTATTTGTTCAATAAATATGCAAG + CBDFG;E<>.>GDD;AG3=FC>A@H>JABFCCJKGI=HDIAKJI9EJ=G?9FE5F@CBEEIHEBI=JGAG3?A.FIG49;I6ED0DCJHJ;.3K9>8G)FKICHECKA?F5DE?H226"JH&/DIJII1GDIA3IG<>492;:EFHD$HHIEIKK:K=?5;F;3FJ59AAFJBFIG>IFB>>GGE+IEGHBE?=?HC:IIDAEG>@IJG?BIHHGJ6JBFEFDIE@KCFIKDKGHIGCKI?GHIDGJJGEDJH:KIJGHAH;I>J?C?EJIG?JKIEI=4J@2G>5@EI>IIKEK;CI@HJI+GKKJJHF>DJAKEHIF*@;JCCHE@JKBDG@F-?GA*JCJEGJEH5FI9A80B+FCF@>KAB4>D?CBCD=DBHHG@G@?=CI2EDHC8?GHJCG?5/B'887DF>C(C:?:@HAE;B0B@;E:CF8@=ED3;>D5:EK=F>F?JAA>FD9HEJ:GGEBD?9=G7:86>FE@CFJIC><6BCKKFHG>:DIIIFHH=HHIH=?IG=JEACFGBDBFI?HFABFECI-CBGFFD@FE;?GBCIEH?7BIG;BIE?FD;HAHH5:;5CD?CCDGCHHA=EEJIC@FC(6::I@@HA:;5E=:@1A==BFAJ??FCA/6E==?HG5B>/6A=>:;B4AGHHFF=B?2DDC49=:6AHH:E8=DIHF6D=AFIHGHDADFIDF:IE=DBD@6CE0AE??>D4IHGDCH?BFGCA+CC?@@?GCCE.F@FD9CICDA@G>EII7GDGGF?BEHB:;D9DGF=GBG1>FHDECFHEFEF2GH;?A6B<>:+3DADFH=CHB8ED8DH@AE70@7>CH>@A=>?>AE?B?+@<6CF:BD=8CF;?A?2:IA/DEAD:EHE;BF>ED7@DGFGEECFGACGH6GF=AGEBIF?5;B8DCG@A=C9BD75H==BDE0F:;>9FBH?AF?>CA7F=D:/@?:=?>86C2ECGDDB=7E/>>>?=A7<=CADE;@FGC==4>CDD<6@E@CB>6DD,@CA>CGIIG;A2?AG;C9<::<@C8=CBCEEC>G=G@=&A:<;?G4B>@D>FB@BCGH7DA:@?9EH9:>GGFD@FD0?BA>I@FEFF3G6DDC5ICEFAE;ACC4?HCBD7?EG?IJ<@IHF3DAI?AE@ECF96=HGE:+-?F/B:D>FIEEEIBG3FF?JFFD@/D=IJJ=;.184:6A2C?;=>86>AA)E;<@?BABD':@=5>AB)DDC==;@=?A?8><;BAAE==A<>E@B9:)3<<:3=<=2:7@<-78D6?>7=3A;=95;B>A@A5A9;:=7=C=/8A?,;0;A?62A=A<:?>CG;;+7992=25>;?=>@=>A)?6??@?@>47:*9'>@@@6A6:=BF=5=;?B<.28;<'03>9?7B;@B;??CDAC>:;5)96-,<@0+=3DB6=ED;;@D/?FD;==;;/:899:2&:?B9@0>D@??A<?@BFA>AC@@,B?FAGCAE?D8C4;2CF:>@EG2DE@B8F7CD>;<=)9<7A:71<>;C>9>4=BA=A-3;+A<@A>2:2=B@94><7<58<<;?>>9?7<@*:=;78>:;:;<4<@A;3@:@>?=3<7,858?:4:;;4;;@><:9::<=><>.61)8<=8?=6199=3-51:<><2?AAA79??B>AA?2=>;@@>:><8;??:<6?96:0>;:8<&49>;7<:?8===9A>A8<>@=9?<27BC;@;893=8@ @rCer/2140/1689_55_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTAACTACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCCCCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACAACCCGTCCAAAAAAGCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAAATACTTTGAAGCACCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACTACACCACTTGTCACATCGAACCAACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGAT + .244*141312-511../2022/4325151006+/3-0141.654,.'223,/46.201/,201014-/5*54521566130552,.2,))25)/4645-6.11.'/,5/5+33.0-64+-.1013%.30524*23+1//0*&111(025626202)340202//&-,+*/0241)1,&+11002(20230.0/4-/66134162,63.0,+6611.1-5,)2//&16651/.&.3540.5.1460564/116661/0615-/(-/)53422,*.(*.)30/62/5662/11'*.4/0,*40&-.32'02015362032/*/0/+0//,%,54,121+31240262226512242626352021346625203.35.0221*4002315624044)23,-33122231,21/015464.01(4/2156450+401/1560%'/45141-3153.1./331412.-.03-+110004-/&'(/22032*0+/002446/5/314630322214(53262355*2660605566,5452)01265.52&261545/523231442140,1234463*525556052/425..23)1.23411(3/.12115540/41365-2.4454*564.43+5606.-20*//1*3565331%-023111661504046564,14.25100*220144.5300330.401/-224405304.63163553/.2.202.6552,--321-6551120456355652562-#,($,23+/*/216646-+.14.144/*45.3*56156-.1230(//352//+1120-.+--,+/-(256100015325.-25-42.01)&''"'&.1/01,+00020110)--+,,-*+,*),%%',/1(0.)*$&.$*..'+*+*00(*.&.0+-**')()0,$,-*'),&+&*+$$)+*%%&&''+),**,.'((&%*%')020,+,$/0/'..-+0--(&2/-,,(2/0,./,.+++-102+.'01-.*00'0-+.-,/,10,,.+-$)))./0-*-/(1+1,0,/,2,+(+-,+*))0*0*$1.++#&&)//.,%.%+,,+.-1/211)//')/01002+0,1.-110-10010.0-12.12111/10/+))+-#+,0-1/-,2.,,-'1111./.+)&)*)&&$*%$$,(#(/02,+)//%/,,,0010..*),)/-/+-,,//0-1-/.-0.+/01)(.0+*,11,-,-%,+(*,/$0-,0,*-,,/1*10210(.,212.*.1-1.-0).12/1+&010--,,.--02,1111221120*1101000/'022101.20.0*1220,,-/,0/1/*20,-,011110%0/1.1000'11,-.11--.122000,)(*&+&---1.)02.0,(1%-,*'-,-,(,-')(,.,,),,,+((''('&$%)-,,-',),.,+(,---)-,-.-,,%+)*($&$)'&'*,*%$$&'$'(-,(,-.---,,,,(('+--,*$+(,-&,--,(+%(+&%%#%&'$#%#&%%$&)+(+(''$((&$+*)&%(+,(((((''(,,-,.,))-*---*-),-,---'-+))+,-,,),)----,-,%',%+(*))*+)%(+(,---.*,)(,,,*'% @rCer/2141/1413_60_CCS ATGGGGGCGGCCACTCGGGGACTGTCCCCTGCTCCAGGCGCTCACTTTGCGGGCGGCGCTTTTTCCAGGTTGTTAATCCAGCGACATGGGGAAAGGATAGATGCACGCTGCTTGGTTTAGGGGGAAAAAAAAAAATGAGCGAACGATACGCCCCTTCCGTTTTGTGATAACCAAGCTGCAAGGAAATAAATCGGCTGGCCTTACTGCAATCTACTGCACTCGAGGCTCCTAAGCAGAAGGGACTTGCCTTGCCTCAGAAGAGACTTTGGACTTGGACTTTTGGGTTAATGCTGGAATGATGACCAGAGAGCCTGCTTCTATCAGTCACTGAAGACATAAGGAATTTTTTTTAAAATTAAACTTCAACACAATGAGGTGTTGCCACATCTGCAAACTTCCTGGGAGAGTAATGGGATTTCGAGTGCTTCGATTCTCTTTGGTGGTCATCCTCGTATTATTACTGGTAGCTGGTGCTTTGACTGCCTTGCTTCCCAGTGTCAAAGAAGACAAGATGCTCATGTTGCGTAGGGAAATAAAAAATCCCAGGGCAAGTCCACCATGGACTCCTTTACTCTCATAATGCAGACGTACAACAGAACAGATCTCTTATTGAAACTTTTAAATCATTATCAGGCTGTACCAAATCTGCACAAAGTGATTGTGGTATGGAACAATATTGGAGAGAAGGCACCAGATGAATTATGGAATTCTCTAGGGCCCCACCCTATCCCTGTGCATCTTCAAACAACAGACAGCAAAACAGGATGAGAAATCGACTCCAGGTCTTTCCTGAACTGGAAAACCAGTGCAGTGTTGATGGTAGATGATGACACACTCATCAGCACCCCAGACCTTGTTTTTGCTTTCTCAGTTTGGCAGCAATTTCCTGATCAAAGTTGTAGGATTTGTTCCTAGAAAGCATGTCTCTACTTCATCAGGTATCTACAGTTATGGAGGTTTTGAAATGCAAGCAACCAGGGTCTGGAAATGGTGACCAGTACTCTATGGTGCTGATTGGAGCCTCATTCTTCAATAGCAAATATCTTGAATTCTTTCAGAGGCAACCTGCAGCTGTCCATGCTTTGATAGATGATACTCAAAACTGTGATGATATTGCCATGAATTTTATCATTGCCAAGCATATTGGGAAGACTTCAGGGATATTTGTGAAGCCTGTAAACATGGACAATTTGGAAAAAGAAACCAAACAGTGGCTATTCTGGAATGTGGCATCGAGCTGAGCATGCTCTGCAGAGGTCTTATTGTATAAATAAGCTTGTGAATATCTATGGCAGCATGCCCTTAAAATACTCCAACATTATGATTTCCCAGTCTGGTTTTCCATATGCCAAC + 13,0.,(&/)/.++/'0/5+554,.-1/0-+,2.),(,4*'*'/(-0*1100+1201.//255&653,10*(1+*,&/..3/+*$+.(*-$#+%2./35-/+0+(2.253*(/2+*/,)',,.'+.-)(*+,--$**.,..,0.((*+/+-/*(-)5/,.04'/..0.200%/(**14064/,43&3662.52-403..06402043650/*30/.12544645.2-65461*..352-63-5..56.4,12,1110.05003,01.,(-)/+/20343-'1.,3/5+51516/00(.040-1//(.31.621-%**0/53-+44665265/113*.*./420/203./.#25.15444-02103/3441'.*0/--+'$&,'33./42)0/4'5646..-*%/-.,05-/34$-*-#132466/515635.55430%0156411,,.+-+/4442,/,-.5606661*2/54008/:8-701-737741=44*565:<=:)>:9>=:;960.42637.;976>:83&)&5<-02,,+-#3734=<=0:8756;7571;:524609++/146/364+5=0,.-6674.*.75/::9-+0(1-77/./0;64,04%0660).0'433)441-;95731:84)4,'*-2212.012680360/472156(0--/4)445*.*6-00419530510'+01-%3/22524-96335/.,.%1:5,58211)66103-86'.99737-#'046::544684277%994147:38974979694955/83-66543+2/+5+60.23%93651433735556438155/6982;624,4'3=3;84299558=025;=79-97'2334,/-*'-./740';-/4631624+1.8.5599,,$303267-572+35,0138:;786435.30$,3665.:997:926,**'-457/&3340122:495514&65'.,4,*%0,69421*,4544056958/40/3-&,,/5.26651/&/3,.50227519/4043.19262/36:747365.32,9/::91-2684268587::6393.32304.3688*40-481.8934815515&795575143/.2+182*++:341,''15100--,3*4/340636100+105402156205442-/1*4403.52-4.($14/12$,145-4(2352'1/3.4..-%.*44604//4355/062120-510-0)2-*43514/2416326115021554+*/+)/03554041/01+5114451-/+./6050010344616220.%./*0/)/+22640-3/24).**,*-'/,(.4+)/-*-.-02'522 @rCer/2142/363_60_CCS TCCTGATGTAATGAACCTAATTTGATTTCCATTTTAAGGTGGTGTCTGTGCAGCTGGTATCCGGTTCTGGCTGTCCTATGTCCAGGAAGAAGCCCATTTGTCGAGGCTGACCTTCCTTATCCACACAGACACACAGCCCAGCAAAAGCCTCTCCTGAACCAAACAGACCTGTTGGTTGGGAGACTGCCCAGACATGACTGATGACGGGTTCCCGCCTGCCTGTCCCCTCCCTGATCACACAGCTAACAAGGCTGCCTCCAGCATTTCCTGATTTCCTCTGTGGTAATAAAAGCTTTCTGTGCT + ,1459675695637-4)4;876+?==;468B@@BD>A?:;&&(A=?8829==?B6<>8;;4)A@/?,@C=6??/<>>3>DDC@<4CBBCF?F>B<>BA06/@CB@A=5>8A<<9.58:BCB:2&;;368HA@FAFBCDHFIJ?F7EF?=?9=BB85:BDFB=CB>:BEAH5?FCFDD9CEE@EA96A@JJFHBDHHIE;CHGB@?88)FIEEEHF6=F@GBBH>ID@G @rCer/2143/25_1605_CCS ATGGGGGTGGCCGTGGCGGCTGGTGTGGGGTTGAGTCAGTTGTGAGACCCGGAGCTGGTGACCCAGCGGGTGGCCCACCGAACCGGCGACACAGCGACAGGCGTCAGGGCTCGGGAGCTGCGAGCCTGGCCTCGTCTTAGAGCTCGGCCGAGCCGCCGTCGACCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTCTGCGCTGTCTCTCCGATGGCGTCCGCCTCAGGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGACCCGCCCACAGACCTCAAATTCAAAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCGTCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCAACAGTGGAATCATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGTGTATTTGAAATGCCTAATGAAAATGACAAATTGAATGACATGGAACCTAGCAAAACCGTTCCACTGAATGCATCTAAACAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACTGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTGTCAGAAGAAAATCGACACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGCCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTATTTCTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCACTGGTAGTACGGCCCGCGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTCACGGTTAGAAAACCCAATAAAAACAAACTGTTCGGCTCCTGGACAAATTGTATAGTACCAGATCATCACTAGCAGATGTCAGTTGCACATTCAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAACAGATTCTTGCT + KK:KKKKKJKJKKDCKKKKKKJKJKK6KKKIKKKJKKKKJKKKKKKK(KK@KKFJJKKKKK:KKKKK.KKIJK?KKKKKKHKIKJKKKKKKKKIKKEKKJKKKKKKKKKKKKJKKKKKJCKKKFHKJGKHKKKKJKKKKKKJKKKKKJKKKKEKKKKKJKKK(KKKKJ4KKKKKKJ=KKKFKKIKKKKKDKKK;KKKKJK*KKKKKKKKKKKKKKKKKKKKKKKKKJKKKKJKKIKKKKHKKKKKKKKKKKKKKKKKKKKKKJKKBKKKKKHKKKKKJKKKIKKKKKKKKKKKGKKIKKIKKKK=KKKKKKKKKKKJKKKJKKKKKKKAKKCKKKFKKKKKKKHKKJKKKKKIKKKKKIKKKKKKKJEKKKJKKKKKIKKJKKKKKKHKJKKKKGKCKJJKFKIJFKK=K$KHKKKKKKKHKKKGKKKK8KKK=KKKK@KJKKKKKKKKAKKKKKKKKKKKCKKKK7KK@KKKKKKKKKKFKKKKKKK7KKKKKKK(KHGJK=KK?KKIDJKKIKFKKKKKKKKKKKKI;KKIKCKKKKKJKKKKKKKKHKIKKKKKKKKKKEKKKKFKKAKKK6KKKKKK?KHKFKKIKKKKIK:KKJKKKKKKKKKKKHKKKKKKKKKKKKKKK@KKKKKJKCKKJKKKKKKFKKKKKKKKKKKKI9KKIJKKKKKKKJKKKKKKKIKJKDKKKKKKKKJKKKKKJIKKK=KKKIKKKKKKKHK?JKKKKKKJKKKKKKKKKFKKIFKGKIKKKKKKKKKJKKJKKIA0KKKKKKKKKK'KKKK4JJKKHJKIKKKKKKHKKFKK+KKKKKKHFI9KKKKKKKKKKJKKKHKKCKKKKKKKKDKKJKKKKKKKJKKKKKKKFKKHKKKKKKKKKKKKK9KKKKKKK=KCKKKKKKHKJKKKKKKKKKKIKKKKKKKKJKKKKKKKJKKKKKKKKKKKJKKKKKHKKKKKKKKKKKKKIKKKKK9KKDKK8KKKKKJKKKKKKKKKKKKKKKKKJJKKKKKKKBKKK1KKKHJKKKKKKKJKKKKKKK%KKKJJKCJKKHKKKDKKKJKKKKKKKKJGKIKKIJKIKKKHG8JI1KKHGKK=KKJKKK>KKKBKKKKKHJCKKIKJJKIKKKKJAFJKKKKKKKDKKKKIKKIKKKGKKKKK-KKBKKIKKGKKKKJKKKKKKKKKJKJEKKKFKKEKKKKKKKEKKK)KFHKKJKKKKJKKGKKKJKKKJKKKJKKKKKK.KJKKKKKKKCKKKBK(KKJ>KKJJKKK?KKKAKKBKKKKK@KK1KKKK;KKKKKKKKFKFKKKKKKKKKKKKK/KKKK7K*KKKKKIKKK%KKDKKKKHJKKKKJKKFKKKJKKJJ+KKKKKKKCKKKGKHKJFKJKK1KKIKJKKK@KKEKKKK4KKKKKKKKJ=KKKKKKKKKKKJKKIKKIKKKK @rCer/2145/1733_57_CCS ATGGGGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACTCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAATGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCCAGCCACTCCCCGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGT + KIKK$48<3KKKKKKKKKKKKKKKKKKKKKKKKKKKKKHGKKKKKHKKKHJKKJKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKHKKKKKK>DKHKK(KKKKKKKKKKKKKKKKKHKKKKKHKKKKKKKKKKKK/FKHKKKKKEKJKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKIKJEKKKKKKKKKKKKKKKKKHKKKKKGKKJKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKK;KKKKIKKKKGKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKKKJKKKKJKKKKKEKKKDKKKKKKKKKKKKKHJKKKKKKKKKIKJKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKJKKKKKKFKKKKKKKKKKKKKBKKKKKCKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKJKKKKKKKKKKKKKKKKKKKKKKIKKIKKKKKKKKEKKKKHKHKKGKKKKKKKKKKKKKHKKKFKIKKKKKKKKKKJKKKKKKKKKKKKKKKFKKJKKKKKKKJKKKKKKFKKKKKKKKKKKKKKJKKKKKKKKKJKKKKKKKJKKGKKKKKKKKFKKKKKKJKKKKKJKKKKKK0KIKKKKJIKKKKGKKKKKKKJKKKKKKKEKKKKKKKKKJKJKKKKKKKKIKIKKKKKJKKKJKKKKKKKKKKKKKKKCKKKKKKKKKHKKKJKKKKKKKKKKJKKKBKHHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKDKJKKKKKKKKKKKKKKKKKKKKJKKKKKKKCKKKJKKIKKKIKKKKKJKJKIKKKKKKKJKKKKKKKKKKKKKKJKKKGEFKKKKKKKKKKKKKKKFHKKFKKKKKKKKKKKKKJJKKKKGKKKKKKKKKKJKKKFKKKKKKKKKKK;KKK3KKKKKKKKKKKKKKKKKKKKKJKKKKKKKKJJKK5KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKK;KKKKKKJKKKKIKKKKKKKKKJKJKKKKKJKKKKKKAKKKKKKDKKCKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKJKJKKKKKKKKKKKKKK?KKKKKKKKKKKJKKKKKJKKKKKKKKKJKKKKKKKKK1KKK,KHKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKJKKKKKKKKKBKKJKKIKKKDKKKKKKKKKKKKKKKKKKJKJKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKHKKKKBJKKKKKK6KJKKKJKKKKKKKKKKKKK9KKKKJKKJKKKKKKKKKKK-KKKKKKKKKKKKKKJKKKKIKJKAKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKFKKKKIKKKKKKKJKKKKKJKJKKKKKKKJKKIKKKKKKKKKKKKKKKKJKKKKDKKKKKKKKKKKKKKKKKKKKKGKKKKKKKJKKKKKKKKKKKKKI>8(. @rCer/2146/2233_56_CCS ATGGGGGTTCGGCGCTCGCCTCTCGGCCCTTGCTCCTGCGTACTCGGCTTCTTCCAGTCGCCTGGGCCCGAATCGGGAAGTGTCAAGCGGATGCCTAGTTCCTCCACCTCCGCGGCTATCACCACTGAACCCGGACCGCCTACCCAGGTCCAGGGCCAGCCGCCATGACGAACGGCGAGAACCGATGCCCTGAGCGGAGGGTGGGAGTGAAGGACGAAGGGAAAACGTGGCGGGCAGGCTCGGGACTGACGTAGTCGTTCTCCCCGCCCCCTCCCAGCCCGGCCCCCCTTGGCCTCTCGACGCCCATAACTTCTGTACCCCTATCCTCCTCCGCGGGTTCCCCCTTCCCATATTCATCTAGGACCCCCAGTGCCTCTTATGCTCATACGTCGAGTTATTATCCCTGTCCTTTGCTTTCCCTTTTCTTTTTTTTTTTTTTGGTTTTTTCTGGCCCTTGGAGAGGTCAGTCCCAGAGGTACTGCTGCTATTTAGACCCAGGGAAGAGAGAGACTCCTCCTCCCAGCCCCCAACGTTCTCATACTTTCGGACCGTAGTTTTGTGGAGAGGGCCAATAAATCACATAGAATATCAGGCCTCACAGTTTTGGGGGTGCTGATGAATGTAGACCCCACAAAAGGTTCTTGTTACGGAAAAATGCCAGAAAGATTTTTGATTTTAAAGTCCTGGCGGGACGATCTCACGTGGAGACCCTGACTAGTGTTGAAAGGGGTGGATTTAGACACTGCCTCTTCTAGATGACGAGGCAGTTGTCACCCTGTTTATCTGACCTCATTTTCCAGGCCTCTTCAAAAACTTTATAGATATGAATTCTGAATTCCAGAGGAGGACAGGAAGGAGGGCCTTCATGATTTTTAGCGTCAACCTTAGAGGAAAGAAGAAGAGAAAGCCTTTTAGGCATTACGATGATTTGAGGGGCTCCGGAAAGCATTTCTCAAAAGTACTTTGTCCATAGACCTGGCATTGAAGACTCGAATTTAACCTCCTTGTGAATTTTGCCATTGTCTGCAGAAACTTATGAGAGAAAAAGGGTAGCACGTAAAGGTATAGTTCCTCAGAAAACCTTAGTGTATGTGTTAATTTACTGGACCCTTTCTTAGTGACACCCAGCTGTGAGACAGTTTTACTGGAGGGAGAGAGGTAGATAGTGTGGTTAGAACTGGCAGACACTGTTTATATAGACTATTCATTTGGAGCTTTCTGGGAAGTCAGAGGTCTCAGGATACTAGGCACAGTAAGAAAAGGGACATTAACCAGAGGAAGACAGAATCTGAACCAGGAAGTAAGACAGCAGTTTGACACGGTAATTGCTGAATAAATTTTAGTCATTTTCCCCCATTTTGTGGTCCAGTATCTTCTCGTTTTTTGCAATTAGGTGATTCATTGTGATTACCTGTACAAGAAATGAGCTTGGTTTATATATTTAACAAACAAAGCTAAGAAGTTGAAGCTTTCTATGTTGAAGCCTTAGATACTTTTTCTTTGTTTTAGAAAAATCTGTTATTATTCTGGCAGAAATTCGGTTTGTTAGAATATCATGCATAAAGTGTAAGATACTGATAGGAAAATTGTAGTTATGTACATTCTCACTCTTGTAATTTTCATTAAGCTTTACTTTTAGCCTTAACGTATTCTTCACCAACAGTTGCACATCTGACAGATTTGGCTACATATCTAGCTCTCCTTTATCATATGAGTGATTTATAACAAGAACATGTTAAATTTTCTTTGCTGAGTCTCTAAGGATTCGTATGTCTCAATCTATTGCCAATGCTAGTCATTCTTGCGATGCTAATTTCTGCCCAGGATTTCTACTTCTTGAGAGGTGAGGGGAGGGACCAGTGACATTTTAGTAAAGGGGATGTAAAAAAAAATTTATTGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATGCAAAAAAATTAGCCGGGCGAGGCGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAGCCCGGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCATTGCGCTCCGGCCTGGGCGACTAAGCGAGACTCTGTC + EEKKKK8HGIE?IIEFIFJDIKIJKEJDCHBKEGHEAHEHEEDDIH;DA3C=8EB<@HGG@G@BB?GC@:G9HJHKJI0HKGIJJ:CHI=JIIH9FBAGGIEJKEHK@G>?JIHJFJKKFJE9?EGJJIJIDCJFKBKJJJH?GKIDCCJ@JKGEDIIB>JEJKKBHIG@DGI9EKKBJHDF?@JAAJ3HEHJJ;JJI@@KKKBKDJJKJD3EDKIIAJ@FI@DHFKK?KHJ3GK@KFG9@KKK5H@GJDIKFBHEFJKKFKIKKKJ?K9KKHKIGKJKKHIIEJJIKKKJ+IFDBKHKAKJHFKIJJHHBKKKFJHKKJIK3IKKCKHJJ8KKBJJK6?JJIJJHHEJKKJI%KDJJJJJ&JJKIKKDHGKEIBGKJKEFKJKK@JIBKKDGHJKKKK5KKCJKEKKGIIJH$@EGCIAJJFGKKKJHKKHJJHIGGICJBCJJKCK-C;DKJHF>KKI>FKJI.JKIGFAHHKFKJ@CKGHKKBHFKKK>KJKIKJHJKKJJJ=KJKJ:IJJC:IIK5HAJJKK=KICEF'KKHJJJHFKJKII6JJJGHFKJJJJBFJGIKKKEIG>IH:IIIKEIKKCKJJJJKJHIF;J>JEIIIEK@JKKHJHFF?GKIJK@KDIBJK;IHJG9F:HBKICDJJKJJI3FGKKKKHKIJG1KAGBI2IKKKK5IIF4IFKHK?IIJKFK:DHCIBHC@KGKHJEKKKIKEKGKJFJKJKKG.G1JKKIKJKAKHJFHKJKKHIKIHG2HJAKKDKIDKKJ<@KHFIK;GKDFIKKJK@GCKJKCJ@KGKKKJ;IJJKKGKJJKJJ-CEDHKKJJIKJFDDKJJ:?JHJKKGJKHFJFJKJKDJJCIFKFIJHJ;KKJHAJJK,GJ>6KIJAKKKIKJJI5IHBKCJJIJJKKKJ;GHBFJKIJJGIJKCKEJFKJFI@KGIKKJKKK1JCKHKGIJFFFJJJI?I>KKHIJKKJKKI>KKEEIDKIKKJKGKKEEHGHJJKJAEJGIIIJAECKEAIC5IHKKIH5HHIG7DJEDB@DG2ACDHD*2;D9FDFF3CJDII7BJDGDKIDC?=BFFDIFAFKGG>HFJIJGBIHG9EEDECGIE4AF,@G5JDHDJI7CG5G>BJEKH@KJEA@CIJKKKHAFKHE7JCGJFHH2GH>FAKEK=F:JJDDD?G9IGGJKJGDFIJ:ICBEG94G@??<5BFH?AIAIGAEDFA;8EDGFIGJJDDGFIKKIKKH5FGJ;IDIFJIKJJHJIIKFDG7CED>FHDIJJJCDJJHJ@JJBEJGCEFEG8EE7GGKKJFJIJ@=BDCBHJC=IJBEHED@?HJJKKK>FHK=IHHEEE8>IJKJK)IICKKEIKJ8HKKEFJIIJHHI(DI-GK?EIDJ@IIADF>JHIG;BFCKHDKFJJAGK>ICKKIEJKJ9IJBFHKHIHAG9@JIFDDIJJJJKGJKGGBKGKJDJGK:JIHJ@IGKKIFE=0>JJFHCGJHJKJG8KHIIKEFGF/KIFIJIIH0KK@KCGHHDIEAIIIIIHE4JHIGFCH;HFGDHKF2FIEB6FCHGJKIACBA:FKFJJIIFBKHCKBKGKHHG>815+55=?:5:5;<;8<<><2<:9?7=8:3:<7;;.9524,08><982897468;463>78474)05751$;6798?7:250*=99495:?;>>;?9;*9<1;:9184><;;-4168:8;88==9=;*7100.52731797:9;.*9;>9;<3:38:9'128572:>99481:37;89=39=9+2275):66.%3?479:2;9;:0>>9:8=;:,7?29:83708=86989>>77=$0*+#)6,;8*75=8>==7;1=4<6368<3:9>87759=1+61<6>89>>:266;+=9<17;046-887877=771=8>>>>=87557<415$792;2=5>:73;8>?>;9>?486;6355'=;9(19=67892,797>47?28,;673979719:7<2676:3#67.%<08-;76<7>:892594:9:::8::22*5/2,3*4345)04.55/2/4661600/.2.460422434'(%0-'2/2516/2*/-$'*5*55142114*50140'434/))5-2.%456145-362353&3(3454'4/624/6452/*366,2425555(50(55+3/31/45,22.%515/-4$32541416,133150-/&044))/0.)./1)/0.11/254623*3.562,$63251*422240+&//3)3,0415432221.--215400100&,,6/2003416552.5543.,,-/10/-4,3523-)(-$%+$**..0/05640635/2.2+26111+/6620/)11+101/066355104/442*-+$454/1/525016321*2+65406504/6440&/2/'()++-/&2-122+411-4321(,#/-/+2.,4/624..--)020$-5524235%+/*4.1*0534*565555.34/5642.03/,404654*()03-0,/6))4/%111*646-42556.15542.'.0+*#.0564234/.32&0351232564321-$,41012%5551345,5/,/2-4,3$462/0+#%36/565445).5,04016522250.24+210/*.263651+2/15)4160-213(0-/4$461411/*20*4.634)43215+*62$333+141*1/.5464233)2)04*0410&22)1/612'3&41/1/0*46656552.155545542.5/20235/6555156404/(4)042+1/026401*.#&%4($//-*46.2.2.34/+*+%00/10.46.23+66444416,*-43513+551644065-(45*644*1,54455.5213$/3-+453.2+41/3,40445)3&12252.02,(*1---)/$')654/530-1)2041.0..5145442)00+516/54+12,/.)4%2102+,'5,,612+.,.25153',-66304554*(/1+65060.35+233130456,32&325+4662++4)/22+/53.0,421220/54/-5212/0-146//0,/.,2561535255-162214403+544-1243666165,05-)0/61./4.)-56662164555/.3'466356236534$%-400%/3+053)5/.5,15(1535 @rCer/2154/2381_57_CCS ATGGGGCACAGCAGCTGCACGTCCCTGGGATCCACATCTCTTCCAATTTGCAGCGTAGCCCGAGTCGGTCAGCGCCAGAGGACCTCAGCAGCCATGTCGAAGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCATGCAGCCATGGCTGACACATTCCTGGAGCACATGTGCCCGCCTGGACATTGACTCACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACGTTGAAGGAGATGATTAAATCTGGAATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACTCATGAGTACCACGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCTGACCCCATCCTCTACCGGCCCGTTGCTGTGGCTCTGGACACTAAAGGACCTGAGATCCGAACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTCAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTATGGCTGGACTACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTTATTTCTCTCCAGGTGAAGCAGAAAGGTGCTGACTTCCTGGTGACGGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAAAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTCGATATGGTGTTTGCGTCGTTCATCCGCAAGGCAGCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAGAAGGGAAAGAACATCAAGATAATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTTGATGAAATCCTGGAGGCCAGTGATGGGATCATGGTTGCTCGTGGTGATCTAGGCATTGAGATTCCTGCGGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGGCGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCACCCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTTCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGATTGCTCGTGAGGCTGAGGCACGCCATCTTCCACCGCAAGTTATTTGAGGAACTTGTGCGTGCGCCTCAAGTCACTCCACAGAAGTCAGCGAAGCCATGGCCTGGGCGCCGTGGAGGCTTCTTATAAGTGTTTAGCATGCGCCTTGATATGTTCTGACGGAGTCTGGCAGGTCTGCTCATCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCAGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGAACCTGAGAGCCCTTCCTCCAGCCCCTGTCCCACCCCCTTCCCCCAACCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGCTGTAATGTGGCACTGGTGGGGCTGGGACACCAGGGAAGAAGATTAGTGCCTCGCTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCACCCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTTCTTTCCTGTGTATACTCCGTCCAGTTCCTTGAGAAAAAATGGATGCCCAGAGGGACTCCCAACCCTGGCCTGGGGTCAGGAAACAGCTAGAGAGTTAGGGGCCTTAGGGCAAGGGGCTGTTGTTCCCTTGAAGCTGACTCTGGCCCTGGCCCTTACTTGCTTCCCCAGCCCCCTGGGCCTCCCCAGTTCGCACCTGTCCCCGCCCTCCACTCAGCTGTCCTGCAGCAAAACACTCCACCCTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCGACTACTGCAGCGCCTCCAGGCCTGTTGCTATAGAGCCTACCTGTATGTCAATAAACAACAGCTG + 899::2')2<9<7;7759=889=784==15.969;=69>;=::874<;/=866<59>;=?<=>>;7=43720:>=79::?;0<9=>47=65?583967=;:<=>*<:=;:7<8.804:=8:;3>;79>:497::=7>54884>>><2=8=95;,8668649497:9<796:97;6=>:;63;44;66&137>=:=88>9=;59:;=6;:=/5/259189<,=7<6>=837211<<-.6.4/2864/6=7=:58:8/3;>0:94<849>=;767792:9.;82/79>==;;?5:9:?;7-58=69:=81:6<98:9=;;85279:85=8?<;29865)01,2085=:=5769:>>3;934.281=77>::8/=9:8398;39;18->;6==<8;:==<<=8=;=81930>7;>==68:678.:/827-533+87388;;0:;>==83484/<5>7<>;==/9=9;75=496*22'521=;29>;9<7?8>?<7;<;:7,:77:=::<97:9;>94:7'<<<:=6>299==/8/534;;838(44.)5836/3.200:6:8==99>><3:*:069/68=9<8527=94997238<<26=7:(35+40;16=:74007<<9669484/1;==698$046-8<8724444;>;284999<.:5-4;::6524:=9:2851898:<6/1$39<225-<>8;51./+(:489:7<-/4.771.2.3>33867<;5::0688&.77+6>>:,25715:88=?>5=;27<;1<8>:78;>?==<77<=:<94/.3507.25165+1*:52/1'/9:>:<85>;=>74834676<=:9=69=9>==963362=896228;;;+===77;1=3<8>;9714292583>49?=6;4>==9<793;872369004:=4:84,5/74.:4*$*=998+5179;5663?;,==38;.45.;7:=563*886&??<=:8;979()&78<2<=>3<-6:47)6,1;69;8:;85.;66=<641#3:8.0873&,.2716/7744;591<7-8616+54)=3>9,%"1&$%7(.463("76233$%9:8;*#)#63/)$:>;2#+'$68.4*((7/4(#*''&##'/36&)+*-3,)9-(3)23*4%$!!,#"#+8.,861.206#2632&'.'75800;4&&$%#%)$6*8=)&&('4-$#&&'%%%$%9,-#5)%&#"6&%$(0<=<=9>85<6;67678;<0.08364:5332+.;2/,$$&+,-.0416,<69;<5.6;5;3984364<.674--113:4*(/931689.9/28.)-5./2,%)2072004&)5+/.22721-62=56*),('*856,33-11'<5=/5882/846/;49>2097/631',/+719975-1*'99:87:<2;758-<20*39:8+3<4;65<9&<>:99.6447<.8933:74584896+22956<=:99811497;367<36503:9:3/34+1<65,9*;=463-3+$*((1-11472:631251613;390?;247500.8:6+73446'5705/+/0-,13&11+6.;52818859110/12150696-60/5;8=3:98;666$78.+:6<;9?5:8:+86500/$55/3'13036/<<5:2:<5;>=389177125,62943,9;921;=>680;,<>9=957;<::30>;:4,,.4<=;.5/,0>::747*56<);3<231893:89'7<315/79<31.(5,:<4>64:/;9443,:2026655=-.;1%2<378=289>/5,<<*744<)5<9?7:3/403*2)::6<7>87-944;555?:3146;;;5=692215,&43037;65./+825%115=<08/795977:2909=3=<;?8=92775-25:4499938:398;588468-;:47:7(<<;=036'/;.673<-:=8634)1(33;52330752801511<4<7;<:72:;542/504)*$)-1-#40+.1.037/.751,1$3*7)/4;47;8/557;96;;378;5=9<7<7;8<'70(.:70:(8982::8651+=4.;=:5=038:-3+95=8;879;8>,:<68892:39.90332909578079:3)02061,($41484*)03/6-47-6868:,'(.+).'/1/(1&.3&/,1.4-0.0-1.0'1.(22.13001422133+*01./'2/165/40-/440/-61351//,300,03#*-(%12--(/-*/%.+$+%%13650)(1+34'-.23-24.4-)1,22&.-.,#2./.%0*,+%.-.0633,42,/./25/-"--1/%/0.3,.0/2233/-&+.114/&'-&.-.-0+-&)%.00'&(,+.*(0+$//-5*$2--.%0%$*.-+./2.)/002.5),1.-+(-*/).,*/,2/264&1/0*)+/0'.,(+4(1+(1&%%,,/4/-.1$-%&/1//0-(&,-2-04454/1/1+..)'.0%.,/-/.1)2,--*-$&+2-21*))'+)+/2**'+)*'.6/23/,-*')(-+/-$+,1//-*)%%**-/-1+/1,.54$00/-+125.1*-0%21230///*-%32-.0-/314./23%-/.0/-#343-,404*0(.0'0-%$$-4.2(*1-2-.'($,(+,/''-1(246/0'.%'/0*2-&1/,/266342(-0212.4203/.1$1)+)$.-.1*411/653.10(0%4$+.0,,+,+/43/,,&)+(0+(,/.320./,%.4/225,02313-)(0421--.+'%&-,%''&'2/+1-#'-20511/.'-),/.(4+1//,-*"%03401-+(..1+11/22(&+*&0*/-,-./2.)+)0..**%)+*+25),*//)-+(.1.,0/010/12+0.1.-1,+..+(&++1-)*1,,%)/,%,,+ @rCer/2156/26_4193_CCS TTTTTTTTTTTTTTTTTTTTTTTTGAGTCTATAATTTTTCAATAATTTTAACTAGCTACAAAATGTCAATCACTTCACAAAACTGACAGATGAGACAGGAGGAATTTAATATTACATGCTATATGATATTTATCTCCAGTTTATATTTCATTCATTTATATTATTTTTTAAAAGGTTTCTTATCAGCTACTAAACATCTCAGCAAATTTTGGTGTGCATAGCTCTAGATTAAGCAACAAAGAATTGTACTGATAACAACCACAGGGAAATGGTGGTTAGTAAGAGTCAGCCTTATAAAAATTTACATCCACACTGTTTCACAGCAAGATTGCTTTCTCCAAAACGTAGCCATCAAAAGCAGCAAACAAACCCTAGTATACATCCATTTAACATAATTTCAGCCAAACATATATTTGCTGGAAATGATTAAATGGTGAGTGTGTCAAATCATCTTTTTTAAATTCTTTTTTTTTAAAAAAGGATGATTATGATTTAGAAGTCTCTATATTTGACAGGAAAAAAAGTGACACTACTGCACTTTTTGCTGGTATAACTAATCTTGACATGTCTCAATACTGAGCATGCTTTGTTGTTGTTCTGTTGTGTTGCTGTTGTTTTATGTGTGTGTGTGTTGTTTCATCAGTATGCTACTGTCATGGAAATTTTTGTTTAAGTAGGAATCTAAAAATCTATTTATTCTCATGCATAAATCATAAATCACATCACTTTAGTGCAATGCTGTTTATGTAATTCCACATTGTCTAATCATGAAATCATAAAGACAGATAACAGCCATGAGGAACCGAAGACGGCACATTTGAGAGATTCAGAGCCTGACACTCAAATGCTGTGGCAGTAGCTTCTGTGGAATGTCACAGTTTTACAAGAACAATACTGTGGATTGAAAGAATCAACAGCACATTGAGCATTCTAAATTGTTGTTATTCAGCAATGCCACCGAGGAAGAAAAGGAAAAATGAATCAAGACATCAAGGAGTTTAGAGCCACCAAATGACCACTATATACAACCTTTGGAAAGAAAGAGACCAGAGAGAACAAAAGCACAAAAGTATTGTTGGGAAGCTGACAGATGACACAGGACAACATCACAATGGGGGTGGACTGATGTGTTTATGTGTGCAGACTACTAGATAATACCATGAGAAAAGCATGAAGGAGCTATCTTGCCCGATAGCATTCAGAGGAGAACACGGGTGGGCACATTTAACCACTTCCCAGCATCTTTGTTGCACGTTGGTTGGCTCATCAATTCTGGTTTTGTTGAATCAGCCTTCTCCATGATCCTGTCGATCTGGCGATTCTGTGTATCGATCTCATTGCCCATATCCAGGGCCATGTGACGGAGTCCCGATGATGCCGCTCACCTGCTCCAGGTTTTCATCCATTTCATTTCTCGGGCATCATTTGTTACCCTGCGGATGAAGCCGCACTGATGCATCTGCTCCGTTCGTCCACTACACGAGCAGGCTGGTGGCACACTCCATCCTGATTATTGCCCAGGCTTTTTTGTAAGCATCACTTGATTTAAGCTTGTTACAGGGACACACACAAAGCCGCAGAATTTTCCTAGGTCCGTCAAATTCTTTTCTGCTTCTTTCATGGTCCTTATTGATTTGGTCCATCCTTCCTCAATGCGTTCCAGTTGTTCTCCTGTTTCATCCAACATAACCAAAGTCCTGATACCAGCATCTTTACTCTCTTCAACCAGTTGCAGCATACGACGGTGCTTTCCAGCGACTCATCAGCCAACTGGTCAGCCCTTCGCTGCATCTCCTCCAGCTCATTGCGCATGTCTGCGTCTTCGGCCATGGTAGCGGTGGGAGTGGCTGGCGCCTGGGTGGGGTCAGTGATGGGTTTGGCTCTGGACCTGGGCTCTCTCGGAGGGTTGTGTTCTCCGGGCCTCTGCAGGTTGCAAGTGTCCATAAGCAGTGGTATCAACGCAGAGTACATGGGGGACTCGGTGCGAAGCAAAGCTTCCTGCCCCACCTGGGCAATGCGCCCCCACCCCACCGGTCCCCCAGAACCCGCGCCATCCCCCGGAGCCTCCCCAGAGCTGGCCGCGCAGGATGGGCGCCTCAGGCCCACGCTGCTGCCGCCGTCGCGCCGCTGCTGCTGCTGCTGCTAATGCTAGAATGGGATGCTGGGCCCGGGAGGTGCTGGTCCCGAGGGCCCTTGTACCGCGTGACTGGAACAGCTGTCTCCATTCCTGCAACGTACCGGCTACGAGGGACCTGCCAGCAGAACTTCGAGTGGTTCCTGTATAGGCCTGAGGCCCCAGATACTGCACTGGGCATTGTCAGTACCAAGGATACCCAGTTCTCCTATGCTATCTTCAAGTCCGAGTGGTGGCGGGTGAGTGCAGGTGCAGCGCCTACAAGGTGATGCTGTGGTGCTCAAGATTGCCCCCTGCAGGCCAGGATGCTGGCATTATGAGTGCCACACCCCTCTCACTGATACCCGCTACCTGGGCAGCTACAGCGGCAAGGTGGAGCTGAGAGTTCTTCAGATGCCCTCCAGGTGTCTGCTGCCCCCCCAGGGCCCGAGGCCGCCAGGCCCCAACCTCACCCCCACGCCTGATGGTGCATGAGGGGCAGGAGCTGGCACTGGGCTGCCTGCGAGGACAAGCACACAGCAGCACACACACCTGGCTGTGTCCTTTGGGCGATCTGTGCCTGAGGCACCAGTTGGGCGAGCAACTCTGCAGGAATGGTGGGAATCCGGTCAGACTTGGCCGTGGAGCCGGAGCTCCCTATGCTGAGCGACTGGCTGCAGGGAGCTTCGTCTGGCAAGGAAGGGACCGATCGGTACCGCATGGTAGTAGGGGGTGCCCAGGCAGGGGACGCAGGCACCTACCACTGCACTGCCGCTGAGTGGATTCAGGATCCTGATGGCAGCTGGGCCAGATCGCAGAGAAAAGGGCTGTCCTGGCCCACGTGGACGTGCAGACACTGTCCAGCCAGCTGGCAGTAACAGTGGGGCCTGGTGAACGTCGGATCGGCCCAGGGAGCCCTTGGAACTGCTGTGCAATGTGTCAGGGGCGCTTCCCCAGCAGGCCGTCATGCTGCATACTCTGTAGGTTGGGAGATGGCACCTGCGGGGGCACCTGGGCCTGGCCGCCTGGTAGCCCAGCTGGACACAGAGGGTGTGGGCAGCCTGGGCCCTGCTATGAGGCCGACACATTGCCATGGAGAAGGTGGCATCCAGAACATACCGGCTGCGGCTAGAGGCTGCCAGGCCTGGTGATGCGGGCACCTACCGCTGCCTCGCCAAGCCTATGTTCGGGGTCTGGACCCGGCTTCGTGAAGCAGCCAGTGCCCGTTCCCGGCCTCTCCCTGTACACGTGCGGGAGGAAGGCGTGGTGCTGGAGGCTGTGGCGTGGCTAGCAGGAGGCACAGTGTACGGGGGGAGACTGCCTCCCTGCTGGTGCAACATCTCTGTGCGGGTGGCCCCCAGGACTGCGGCTGGCCGCCAGCTGGTGGGTGGAGCGACCAGAGGACGGAGGCTCAGCTCTGTCCCTGCCCAGCTGGTGGGTGGCGTGGGCCAGGATGGTGTGGCAGAGCTGGGAGTCCGGCCTGGAGGAGGCCCTGTCAGCGTAGAGCTGGTGGGCCCCGAAGCCATCGGCTGAGACTGCACAGCTTGGGGCCCGAGGATGAAGGCGTGTACCACTGTGCCCCCAGCGCCTGGTGCAGCATGCTGACTACAGCTGGTACCAGCGGGCAGTGCCCGCTCAGGGCCTGTTACAGTCTACCCCTACATGCATGCCCTGGACACCCTGTTGGTGCCTCTGCTGGTGGGTACAGGGGTGGCCCTAGTCACTGGGCCACTGTCCTTGGTACCATCACTTGCTGCTTCATGAAGAGGCTTCGAAAACGGTGATCTCTTACTCCCCAGGTCTTGCAGGTGTTGACTGTCTTCCGGCCCAGCTCCAAGCCCTCCTCTGGTTGCCTGGACACCCTCTCCCTCTGTCCACTCTTCCTTTAATTTATTTGACTTCCCACTACCCAGAATGGGAAACATGCCTCCCTTCCCCACTCCTTCCTCCCAAGCCCCTCCCTCTGGCCTTCTGTTCTTATCTCACAGGGATCCTATAGGAGGCCATTCCCCATCCTGGAATTAGTTTTTCTAAAAGGTGAATAAACTGGTTTT + %,+)+),,,,)',,,+)'&$)&%%$&)*-+$'#$#%+)*$(-+#)),.+#+&(%+(),,%*(%),))-.,*),&,+)*%'+)&**,,(&(+)*,(+,')*')(-'),(,+((&'*-,)()))$&,,+&#('&&'+&$,*(*,+*-&'+$'%*#'$(#'%$##'(,(&+*(---,+$&)(&.(,,(,+-+-+'***#)'*,'((#*'#++)(---,-,(+&(+&'+'))')%&%(+-)%*(*%)''#%)(,)'+(-(#'")%&##,*#(++%++(,+,%'%#(''(+&&!#'*-')#"))'&&*-),%*-(&+--,(,+&&')*--.,*+.-,%+)&$(-)-..*)*,(%)$&&),--,--,-()'))-,%'%'(%)%$())*'((',)+,)+-+-'+('*)&-&---,)+(*#))&),))((()),',()%,'+*)*&$$**)-)%((#*)(#**)*%#)&%,%$$$'**,+(&---*-()+-*+',%%*-')---))#&#(&&&#$$#*(+-,''$(++)*%&)---**,)++(&((%*+*(*#'(*&%+$&#%#'+**.'--)"&(+)+,*+,'$$&%%)'&,&+'&#&()(((,)+)***#&&&)**((+(#+,(%(+-*--++-*,&'(,)-))#%#&*+(*++($*(%))-**.(*&"()%(+&+,,**,($((.+))&+,,++&(&)-,#$-*-,'),*'*'-+)#--(((+*--))+-(#)&&')(,,*&)$%$#(%(+*,(,('(,'&*(((,,,--)&,))(-,-,)*&('$(*%($)(.+*)'('+))'*',&))%-%%(+-*-*($*++-*+)%*-)+++(#'(('(&+&)'+&#%"**)'))&)*+,0+1,)-/,2-0/1.-&.0-&)(-.*),(+0+%&'11..,,,.'/*--2++&.,+.-./0...-111-+*),*0'1/(,(000&(0&)+','-1./+0'$'(,+1-'-(..)/2&*/.)()#*#-.,1//)//'-++**%+/,10)),+)0,.--/+(,*0+00,'.-*0%--21)*#,+&),-.+*,&(%()%('&*$*1+0-#,,#).-.0-'0*+1&/,,0,-0-...(,+,-+1,-1210+.-.$#&&'*+#('))-,1-*-1+'+&&%#+(-)-/0./)%)&*0'0-01.$(&),1+-)()+//+.*))-*.+2111.-*0,0/%//,-1/,%+.210+.)+,(%.*(%)+,.(//&,'+122)-*--'%-%,1011.)()0-0(-0,),-'--,)2&#'0.0/,+2&-,*'0+0121.0-'----0,0-..,021+,.+-111..)+*.1-0.0()0%,0'.-.1.+--&+/%'+/-2-')))))0(0(&+/)+./*-,//&#$'--1.1/1.,+,%).-($*-/+).-'+%-,)..,.0$&/000*+-/,,)..,11*000/1,1-&..0,-100-1.0(&'-&$)--/+&),-,1-.&#%'-+++*+0/),/).-.111+++,,&(&-0&(#,-*&*/*$+-1,&.*)/'$,-,&+*'.,111&,+,+.,'%.&+00/,110.1+,.0(-*'*$),+,,*//,+'0-/,21+&)*.%.,*&+-/+/.-0+,.'+,+-&(0-.+,1/.2.-1+,-,$&-&.-1,)-.(*/*&+-+1+,&/'2-,..,2-,-*(,**1-1/1)...,0%&$(&'%(*0010+&$.,2,1/&.,/(*(,,(1+,/0.-'--/,*/1../,*1+1.--.0,0011++(/./&0)+.(1.&0*/1,+-,*1.+/+,0,.)-.2,01-*-,%/*,,/-111++(,&-21.0111/1'.1/*+%%%&*01.0)+-(//.-,)/%.,,,-.%-,-..1.1/$.)-+--*-('&.),..'.1110-/--2-,2-1-,*,-+,+-*/.)$+-/#%/-*1)'1&+))1,))*)-,021,.1,/.212-,(/++1.""''))%..+(&,.()++0,110/+*,,&+.*.1221/1-',-,+'*-+'%*--.1/../,%0/0)(-*'11/%-,'$%#')**-%)+,+/1)0*)1.+,+'(+*--,+-+1/0&0-/0%-&,-/'%//+.*-.0-+2%,,-&-0-.-0&/01+&/),+-2(0.'++'&+,*'*)*,-0(*+&(,,1011'-,-0*/.'1.0-/00--0,+%%0-*),)-/,-)-/),/()-0$+-/0.-2.%.+/0$0-$*'#$-1-%,))(,'+00',,2++.210&&*+0($$&)01-*1,+,%,0+1(*,+01+0--/2.0*-,-0/,+...21,#,)+012101,-/.002,0).112+0*.&-+,-*/+0111).1-*(*.1*+/-,&+(0*0)/+--.-0)/.//2.-+*.11,*.--1211%-./&0(/,(2-+1.--.&*+11'('/.1-*,&10.1.2'+-00+..+++,2),+-.+1,-*00#/+(*-.+,'1&,*+*-1./&+2*%$))'&)1.%'*$%+'//,&&#+,1.(01.#&)*+*1-0,-11./.(,1,**,*11+1*0/101*-0-1/-+/21/*%-,.&1%//-,1-'.+,'%&,+*,%./.....-21&/+'-,/02-+-0,-%/../2'-**.$.,,-+-.02111**2,0(--.0*1*.-11210'1.2/.++&.').*)+*%)-1/1..()+&*,+),-,/-+)&(%+-,('&).0.,0,-*--22&+/0-0211',/%*+11,/'+%(-.*.'2-00/+*//11,...&+*+(%,+'#&$),*$*%'&)/.-102*,#&&-+..$-.&(/.0++11.11011.1+*&/+.),*--+/)1100-,,*)*)/$)*02,1*0'11+).,&-,*-+*)))+++(*)*'&'&*),-$'%&*+&(',&/0/0&*(012--*/.-,01,,,&(&*&%*)/1...),'+)1/--1,,,.-(-,,1**,(*%+'$/0./(.,++011)/(.&*,+/',(,-'-%'-*,.0&0/0/),--/,-+,111%-+,(.0..1..'+-.,-),,0+1.+,2-0211..1/,,.).1-)-&+-+%,)+*%&+,1,0,00,-/,,1-112-0'-1-/0,02011/1$0./-0./(1,.0.(&+-/1++).,-0(0-,./2/-.21-++)-0&.,0*-,%//.0/0&-.+12,10)+&&%,,,&)'/1,-+(,)1-0/11.,/,%/,0-*-0-//*,0,),0(01/$'(,/0-&.)*/110-,+2-,01,',&/--),.*0,1./*+.,-,010''$**,(+$)&$*-1*,.-0.,.(.$*-%,,.1(,0&.)'-%,0.-.-/'.,10,,'%&/0-10(10,0/%0-),).$-)+..'..'*+0-'),-...1./,%',20..2),-)/-,-+(%'*,,&/1*--+00,1,-*,+,$)))*,/+,...)0&/*,,,%)*-0+-/%)0'/---*,111))&,),/,0+263223(/3(*&*21./0,&,,.306-3+/+/0314/%/,0*,'650(-*0,.*-.,*,--4)30'.-+&+,/()./3.343,0/*4(-,-54,&///$.11,+.51,21-2411*5353,2.2/,(0/46413044/2/102256422054.26342.42,)-)2-1-2540445/(2(.555/)2,3-.1401),#&)&4)&+2./%)1(,(4/-3)1254+02000++,2(2%++,(/425/551//5(502,-00)430).0)%0+*-/5251/($-'+/.'/.50/545/.3,1.3.+*5.-2($0,42510/,)0340466.450222.3)(-.(/51).363-51//632*(40/031-0(-.11/546-42.1+2400*11'%*14..#')+.,106530/321/2$.0-05130/+105+6/1/6105/.3/5106524*/62.2425210122136,(+,5.25/32/3144.6114)0/.26/0)1610)34021633*5)0.-#3,25.023.520665*42.*2.+1),53/1130)2/04/*/-,--)+'5+,--05+1),/)+'2/*,26525+/$,((,,01004,(+1)//)/1224+)*.+2236)043211*+.-&40(./.63(4355(31.51)2%-06,23'-/0.%200*0).$1114'-+///%2-/5-0,$3'15./2363+315060)+264242*/55360202++-42+,00135 @rCer/2157/25_1497_CCS ATGGGGCTGACGGGGTAGCCATGGCCTTCCGGCTCCTGAAACTGGCCCCGACGACCGCGTCCGTCCGGGTCCTGGCGGCGGGCGCCCAGCGCGTGAGAGGAATTCATAGCAGTGTGCAGTGCAAGCTGCACTATGGAATGTGGCGTTTCCTATTTGGGGATAAAACAAGCACAAGAATGACAGAGCACAGCAAGGTGATAACTGTAGATGGCAATATATGTACCGGAAAAGGCAGACTTGCAAAAGAAGTAGCAGAGAAACTAGGCTTCAAGCACTTTCCTGAAGCGGGGATTCATTATGTAGACAGTACCACAGGAGATGGGAAGCCCCTCGCCGAAGACTATAGTGGCAATATTAGTTTGGAGAAATTTTATGATGATCCGAGAAGCAATGATGGCCACAGTTACCGCCTGCAGTCCTGGTTGTACAGCAGTCGCCTCCTGCAGTACTCGGATGCCTTGGAGCACTTGCTGACGACAGGACAAGGTGTTGTATTGGAGCGCTCCATCTTCAGTGACTTTGTGTTCCTGGAGGCGATGTACAACCAGGGATTCATCCGAAAGCAGTGTGTGGACCACTACAACGAAGTGAAGAACATCACTGCCTGCGAATACTTGCCCCCGCACCTGGTGGTCTACATCGATGTGCCCGTTCCAGAGGTCCAGAGGAGGATTCAGAAGAAAGGAGATCCACATGAAATGAAGATCACCTCTGCCTATCTGCAGGACATTGAGAATGCCTATAAGAAGACCTTCCTCCCTGAGATGAGTGAAAAATGTGAGATTTTACAGTATTCTGCAAGAGAAGCTGAAGATTCCACAAGGGTGGTAGAGGACATTGAATACCTTAAGTTCGAGAAAGGGCCGTGGCTCCAGCAGGACAATCGCTCTTTACACCACCTGCGATTACTGGTTCAGGATAAGTTTGAGGTGCTGAATTACACAAGCATTCCTGTCTATCTCCCGGAAATCACCATTGGAGCTTATCAGTCTGATCGTGTCTTGCATCAATTCAGAACGCTGCCAGGCCGCAAGTACAGCCCTGGGTACAACACCGAGGCGGGAGACAAGTGGATCTGGCTGAAGTGAACGGGCCGCCTTCTGCTCCAGCTGCGTCACAGCGACAGCGACGGCCAAGCTGCACCAGCCGCACTCTCCTGGACGCCATATGGCTTTAAGATCGGGGGAGGGTAAATAATGCGAAAATTGCACAGTGGAAGAAGTGGTCTCACAAAAAGCCATCCATCCTGTAGTGTAGGTAATGGAGTCGGGGAGCAGCGTCCATTCTGGATGTTTGGAACCCTCTGGCTTTGTTTTGGAATGGCCCACCACTCTCACTGGAAAACAGTGGTCTGCTGTGAACGGCCGGCTCTCGGCGGCCCCTGTGGTTTCAGTACTGCCCCTCTGTGCCATTCAGGTTGTGTACGTTGTTTTTCTTCCGACTTCCAGAAATAAAAGCGTTTCCGTGGGACT + KK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK=KKKKJKKJKKKKKJK>KKKKKJKKKKHGKKKKKKKKKKKKKKKK1KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKBKK;KKKKKKKKKKKCKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK=KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKIKKKK8KKFKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKBKKJKKKKKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAKKKKKKKKKKKFKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK:KKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKEKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKGKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKHKKKKKKKKKEKKKKKKKKKKKKKKHKKKKKKKKKKKKKKBKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKK.KKKKKKKKKKKKKKKKKKKKKKKKKKKKAK:KKKKKJKKKKKKKKKKJKKKKKKGKKKJKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKK'KKKKKJKKKJKKKKKKKKFKKKKKKKKKKKHKKKKKKKIKKKKKKKKKKKKK8IKKKKKKKKKKKKK4KKKKK @rCer/2158/25_2706_CCS ATGGGATTCAAAGCACTTTTTTTTATTTTAAAAAGGCCACACTACCCCCCATTCTCAGCTCCTCCTTCGCGGCGGTAACGCCTCTGTTTCTGCGGCGGTTGAGCGCCGATCTTTGCGGCCCGGGATCGCGGAACGTTAATGGCTGTCGTCCCGGCGTCTCTCTCAGGACAGGACGTGGGATCATTTGCATATCTTACAATTAAAGACAGAATACCAACAGATCTTAACTAAGGTTATTGGATACATTGCATCGACATAAAGTGAATTTTTTGAGAAACATGGAGAGGAAGGCGTGGAAGCTGAAAAGAAAAGCTATTTCTCTCCTTTCTAAATTACGGAATGAATTGCAAACAGATAAACCAATTATCCCCTTGGTTGAGAAATTTGTTGATACTGATATATGGAATCAGTACCTAGAATATCAACAGAGTCTTTTAAATGAAAGTGATGGAAAATCAAAGATGGTTCTACTCACCATGGTTGTTCGTAGAATGTTACATGTATCGTAGAATTCATGAAGCAATTATCCAGAGTCCGCCAATCGATTACTTTGATGTATTTAAAGAATCAAAAGAGCAAAATTTCTGTGAGTCACAGGAATCTTGTCATTGCTTTATGTACTCACCTGCAACAATTGATAAAAAACTATTGAAGACCTAGATGAAAATCAGCTGAAAGATGAGTTTTTTAAACTTCTGCAGATTTCACTGTGGGGAAATAAGTGTGATCTGTTCTCTCTCAGGTGGAGAAAGTAGTTCTCAGAAGACGATGTACTAAATTCACTGGAAGACCTAAAACCTTTTCATTTTATTGAATGATATGGAACATCTTTGGTCATTGCTTAGCAATTGCAAGAAAACAAGAAAAAGCTTCTGTTACTAGAGTGTATATTGTTCTCGATAATTCTGGGTTTGAGCTTGTTACAGATTTAATATTAGCCAACTTCTTGTTGTCCTCTGAACTGGCTACTGAGGTTCATTTTTATGGAAAAAACAATTCCATGGTTTGTTTCTGATACTACTATACATGATTTTAATTGGTTAATTGAACAGGTAAAACCATGGTAATCATAAGTGGATGTCCAAGTGTGGGGCTGACTGGGAAGAGTTTGTTAAAATGGGTAAATGGGTTTACCACGATCATATATTTGGACTCTGCCTCATGAGTACTGTGCAATGCCTCAGGTTGCTCCCGACTTATATGCTGAATTACAGAAGGCACATTTAATTTTATTCAAGGGTGATTTGAATTACAGGAAGTTGACAGGTGACAGAAAATGGGAGTTTTCTGTTCCATTTCATCAGGCTCTGAATGGCTTCCATCCCGCACCCCTCTGTACCATAAGAACATTAAAAGCTGAAATTCAGGTTGGTCTGAAGCCTGGGCAAGGGAACAGCTCATGGCCTCTGAGCCCTGCTGGTGGGACCAGTGGAAAGTATGGAATATTTCAGTACGATGGTCCCCTTTGACTTGATTTAGGAGCTCTCAGTTGCAATAGAAAGATGACGAGCACCTTTTTCATCCCCAGAAAAGGAGCGCGTGAATTGAGTCGCCTGGCGGCTGGCTCTGTACGCGCTCTGGGAAGCTTGGCTTCTCCGTGCCCATCTACATGCGCACTGGATGATTTTTCTTTTTAACATTTTGCCCCACTACACTGTTTTGGGATAGATGGGTTTAAGCCAGTTACAGATAATTACATTTATATTGGAATTTTAGCAACTTTTTTTTCAGGTTAAATACATCATTTCAAGTGCTTTTAATTGAACTTAATTGGTTAGGAAGCAAAAAATAAGCGAGTTCTGCTTTTAGTTAACCCTATTTTTTTCTTAAATAGTGCACTGCATGGTATTTAATATTCCAGGAAGCATGAAGTTTTATTTTGCTTGATTTTGGGCTCATGAAATAATAGCTCTGTGAAAATGCACATCTTAATGACTCTCTGTAAAGAGGCATTCCTTACAACTGTGATGTTTCCTCACATAAAAGTTACCTCATAAGTTAATTCTAACTTTTATTCTCCTTGAATTTTATTTCATTTCAATAGCTTGTTTCATTTGCACACCTTTGTATTTTCATTGACCTGTTAGAATGGATGTTAGGAAACCCAGAATTGAAACACAGTGAAATAAATGGTATTTTTAAGAAATGTGATATCTTTTATATTCTATTTATGATATCCATAATCAAATGAGATTATTTTACCACATAAGTGTTTTAAATAAAACAGATTTTTAGTTTGCAGTTTTAGGAAAATGCTTTAGATAGAAAAGGTTCTTACGCATTGAATTTGGAGTACTACCAACAATGAATGAATTTATTTTTTATATTCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGCCGCCCGGGCTGGAGTGCAGTGGCCGAGATCCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCGCCACCTCGCCGGCTAGTTTTTTGTATTTTTTGGTAGAGACGGGGTTTGGTAGAGACGGGGTTTTTTTATATTCTTACACATTTTATTGGTCATTGTCACAGATACTAAACACTAAAAATTTCAGGTCAGTTTGTTTTGAAACTGAAATTGGAAAAAAAATCTGGAAGTGTTTTGTTGCACTAAAATAATAAAATGAGTTG + ,*,,,(($$#(%&'-,%*'*+,+*#(-))$(+,*$*+.,,(*-+$&"%**,-,)(+),*,))'%*%%+)+%+*+.,&,,*&**+,*)*-+-,&+-+**(*+--,(+----+(-,++$("##'(-+)***)'$&)'#(--**.++,)+*,'+***)---,('''())+,,),-'$)(,*.*(&)+..+(,+&&*),*--.-.-..,&+--(,(((-#"'--,''&,+.-,-.+.()*'*#&-*+-,',%&)-,'+--+#''(--,.()--+-,($*.+,+-%*&$(#')'*-&,-**+.-),-,-,.,%(,+)+,,'+-+(,-,,(,-*)%,)',,-+-&'**(++-())()&*,(++-.-.--&,'&$''(&-()(.-,,+..)-+,+.,&+-),''+--+,+-+.&"%+&+*-%+)-.*,(*')&+*-**+&*+,%+())&(,+,-,%'+)+.-()&+*%$(+(+,-)$*(+-*--)(,+.-+-*-,+-*.,-+-,-+),(+)(,,),)*,.-*-+(,+,,'(+$&+.,++()$'''(&&+,-*(,)*(,-(**-'+$,(#*+&,.-+$-,,*)-,'*('+,,-'+'%$+,(+-,''),))""'+)++**&*).+*,,,+))+'()*',.,$&%++*(%++**+*-,&,++,-,(+&+++)+*,,-++&''++,-,-((+((#*),,+).+*'*(++(%(%&(,(+)-,-*.,-*-,(,-+&)*(+*)'+%$'&(+*++*))+,.,++*,+**,(*+--))()+*$*'-,++&)(,)(,,-,&&(,,-)(---+.,*,#)'(+,%*)*%(**&'(*'#+-**+,,()'*..-.--+)),&$*',+&,*,()()**,-*,)$))#-,,)---(&,+.,-,($)-)+-*+-*,,'),()%+(((,),+&*'%--((*,&,+(*((()-(++,.,+(,(+')+,-*--&+++,))',,*-+*,+,,))--+-,-+,(-)(%'(**+(+.%,+(&'+-.,.*)*-)-*,-(*,.--,-)&(&&#'))%+,---)--,*-(-+,)+(-+-'%**-,.+%,,+$'&+&)'%'*+,)%**-*)'(&()*(--+$(#+'(('),-,,,,$*&+)()--+,*.-+-+,,,#+,'*.-)-,+&-+--,&+,*()(#''(--*-+&)*-+*&,,),+)('+)*'$)+-,.--++)$,*+'$(((,,+,,*-,,)*---(,',-,(+''---+(+,*-*---,-.))-,,-&+)+,.-+-),+-,)*+.-+.+#'()*-----,(++)*(+*(,&+(),*')-(,*),-,',-)+,(-,),-.-')$&-,.-(+,.-,,(-+'**,)*),-*-*+,+.+)(,(-,+,,-)+,+(+,-+,#+*-*(&'(,,-.,+.-(&+$+*$&&),,'*%)++$'*)++)**.-+&*&',+#$%'#$(),'('(.-+)+&''*)*,,.-+-)(+-+,+-()&&)'''&'"%++'%%+',+,(+)+--)--.,($))+,-..+-**+--,-,-+.%*,+,+&,+.,)'+'(((&&)**(+-,))-,-*,(',-),,+.--.---*,,-)--,-------+--,*-*-)-)--,-(,--++*(-,+(*(+-,,++-+,-(','(+,(+--,(%,,,)%(%*)-++*)-),,,,,,&,+,+..,"%%&%)*')(,*#))'**(,(*&)+*)+)+*-(-*()'*),))+('+()%,,-,+)&+,%'),,,,+,)+-*.,.,*--,--,$,+**-,--+%(*,/2$/,.2,)*)%,,*'$''#$'(***/,/100'0/,/0100),/1)0/1,0.2111/20,(/-.0//-,1+0,(+0)+11.111,/0./-(1-/0..12021-0,20%++0,0/+00,+*+0/,0-1,,.122&/,.11(0/0221021)).,0.011%.//1111*,-1-1-1--/'*)*-,,-1221*+000./*,*//0*11*+01011/2201.11/-/&../-11+/.',.012($0+--.-*,00*111.*/0-/1&.--1%000(-.110/22012',01021-11.&)10/,&)-.0.221-,,22,,*01*.12,-')+*&),&%$1*-01*1*-.,021100-/*(111/01001&**+-00-,21/%/''()-.*&,1.&.,0011*,,0,/.-21.-/22010,01102-0&-,-,1000,01.01./01*/0.010-0*/0&.,,..2,#/.-/,.-.2220-1*00,+'00220,/2/212/01+000101-,-111/1*/.01',-(%,/((,)/102-/1.-+0-/''0/00012.0*0.22*&00,&,-+&-10$.1111/011111111,.00001-01./10.,+-.-/(*+(./,1/+/*,/-2)1101-01.2.10/1,001&0///11//*)-,010/.-2..//&.%$/.,00&1,000&+-+-*00111-2+&*),.1.-.1/%-+,./,111211-0.*//(0./,$0-1-,,01222221/+#//00//21--*.')).2,&.0+-./-..0.+)..)1100/*00.,/-,/.1-+*'2/10/-+.0/*+)01.01,+.*01,&+,*.**&++.0.22101201-4)300*3533*43446364-536#22231.--2106.2346264653643/+*$-/,**.2*),21405/3- @rCer/2159/24_1934_CCS ATGGGACGTTTCCGGAACCTCCGAGTGTCATCCGCTGGGAAAGAACTTGGTCCTGACTGTCTGACCATGGACGATGTAGCCTCCCGCCCGAAGACCGGGTGGGCTCTCTCCCAGCTGGGTAGTGCGGTAGGGTGAATGAAGACATTCCAACCCGTCGGTACTCTCCGCCTCTGGAGTTGAGATATCCGAATGGCATCCATTTACTCTAGGAAGGCAACATTGGAACATGCCTTCATCCTCTATAACAAGTATATCACGCTTTTTACATTGAGAAACTACCAAAGCATCGAGATTACAAATCTGCTGTCATTCCTCGAAAAAAGACACAGTAAAGAAATTAAAGGAGATTGCATTTCCAAAGCAGAAAGAGCTGAAGGCAGAAACTGTTAAAACGATATACCAAAAGAATATAACAGAATATAATGAAAGAAAGAAGAAGAACAGGAGAGAATCGGCCCGAACAATGGCCATCGCAGCAAGAGCTGGAAAAGGAAAAAACAGAGGGTAGCACAACAGAAGCCACAGCAATTGGAACACAGGAACAGTTCGCATGCCTTCGAGAGATGATCCGGAACAGGACTAAGAAAAGAGCGGACTGAAAATTGTAACAGGAGTTTGGGAAGGTGGACCTGGCCTAGTGGCCCGCTAGTGCCTGACTTGGAGAAGCCCTCCTGTAGATGTGTTCCCCACCTCACGCACTCAGTCCACACAGCCTTCAGACTGTCACACAACTGTAAGGCCAGCTAAGCCACCTGTGGTGGACAGGTCCTTGAAACTGGAGCACTAAGCAACTCAGAAAGTATTCCTACAATCGATGGATGGCGCCATGTCGTGGTGCCCGGCGACTGGTCCCACAGTTTCTCCAGTTAGCCAGTGCCAATACTGCCGGGGAGTGGAGACATGTGGAATTCTCTGTGGAAAACTGATGAGAAATGAATTTACCATTACTCATGTTCTCATCCCCAAGCAAAGTGCTGGTCTGATTACTGCAACACAGAGAATGAAGAAGAACTTTTCCTCATACAGGATCAGCAGGCCTCATCACACTGGCTGGATTCATACTCACCCCACACAGACCGCATTTCTCTCCAGTGTCGACCTACACACTCACTGCTCTTACCAGATGATGTTGCCAGAGTCGATAGCCATTGTTTGCTCCCCAAAGTTCCAGGAAACTGGATTCTTTAAACTAACTGACCATGGACTAGAGGAGATTTCTTCCTGCCGCCAGAAAGGATTCACCCACACAGCAAGGATCCACCGCTGTTATGTAGCTGCAGCCACGTGACTGTTGTGGACAGAGCAGTGACCATCACAGACCTTCGATGAGCGTTTGAGTCCAACACTTTCCAAGAACAACAAAACCATATCAGTGTACTGTAGCCCTTAATTTAAGGTTTCTAGAAAGCTTTGGAAGTTTTTGTAGACAGAATAGAAAGTGGGGCATCACCTGAGAAAGAGTTGATTTTGTTTCAGGTTGAAAAGAAATAACTGAACATATTTTTTAGACAAGTCAGAAAGAGAACATGATCACCCAAAAGCAACTGTAACTCAGAAATTAAGTGGAAAGAATGGTATAATGAACCCCCATATCCCCTTCCTTCTGGATTCACCAATTGTTAACATTTTTTTCCTCTCAGCTGTCCTTCTAATTTATCTGTCAATTTGTTTATATTTACCTCTGGGCTCAATAAGGGCATCTATGCAGAAATTTGGAAGCCATTTAGAAAATCTTTTGGATTTTCCTGTGTTTATGGCAATATTAATGGAGCTTATTACTGGGTGAGGACAGCTCACTCCATTTCACCAGATGTGAGGCTAACACATCCTGAAGAGTGATTTTTGTCAGGAATTATTGTTATTTAACAAGTGTTTTCAGGATATTTTTCCTCTACAATAAAGTAACAATT + (%#((&%'#%$#'''%&')(%)'$'%''%'(#''((#&&$(((()(%)')(()%&%$('$(()($(((%('$$((%$#%#&(%$('$((())))&)'%)'##)#%&&%'%)'$$$&'%)%%#&'(%(($##$$(&))(%((&$&#$#$##$(''%%%&#%%%"&%)&"'$&$$)'(()(&%&%%(&)%%'($((((&)&'(('(()'#%&%&&((()))()$$()($'$$(()('%')(($&(()((($''('%%$$#$#$$##"""$$$%''((($&$'"$%&(%()'%$%#%('#''(((&%$%('(&($$#"""'%%##&$%'&&'()))($%$&$"$$&)&()()((%&)($&&))((###&$"#$%&(%(&)('%$%(((%%(%)))((%##$(()#'&%%''(('"&'%%&'''#')'$#'$$%(('()$()$'(##"%#&$&###"%(#%&'&)##"%')())('#$%('%&&&('#%%$(($"##)))))(&#$&($$'())(%'%'(%&($%%#&#('%&&%(#%$"$$#&'(%((()($%((%&)'))((%'&(&$%&))('$)('$%%#'#%##$$%$$$&$#&(%(())&&)('$%(((&)'%#%$,-(**$,+,)#&$%*)+)*##$%$%*,-)&+)''**-,)+.)-,-)-,(-,)&*)'($'')(--,,'/.(&$*&'*$%$#"(%#"$'('('%%%'()),/,0110,*'#$&#(+*,*&.*1+0)--1-**(-,.0-1..00*0+.0-+*,1,*-+-)$-02,,,01/&*&')+-.--/.,,-0,*.&+*%+(,0+.*')+.&"#.-,10'/*+)+&*()&+&$/-,++*#$$$-.+*0,&//$&)2,-+-.+*+0-1-,.,0,.,,-&+',01%*,%((-(+,-0,,.+102-1101).2+1-211,),+.,))0-..2(*'+*,,.011)+0*,%$%,-.-&,),*.,'(-1,-0$(*,*%++-)'%1,-+#&'&%&,+.).0-*,%$+/-/+&.+)+2.0+*)---1'),+(.()-+/*++,+)%'$.$0$'+-/*-((.&-)')%$%'+-'()(--/&-'&-(*(-,',*)-',&/-&&%%')&*..1.,*)+*(,-&'-*')/(++1-10&1,.,-)/-.0')+.'*-.)000(*,11/%)*012-63+)*11/3262,2/$'+0662,(0-,0(#).*()0135/,).140)520/6*.52+.+'+++(1/-20#,/10./551/-44-5/231-50-50/51-4303-.35/00.112/+*0.354/*-/4140/03-0/-.*1).1215-+14521200133()110)-4/4*1/54642+(2311*.//44/5+.13616/20+002/1)&245004'33/+-2&-/#*16061/25216645*32/1-6.%4541/2150'*%)14.0)1502,2000/0//01+522*2640014-0/151-+/1*+(+&21)5520213-+0,5.*33551%1/12/01-1023.-12)3,)1./2*-30///1,0,2663-115/501.-./3.,,1555142516(',0',/*24,30,'0*/'043/034/%4//-2.1052/055/5/1..*5+/*.3/2,/(+0//.0/14)22/,$1141).2'*+,(23..65525&*)04153201../+4*33.2+2.,/2425-2,/2/*-10*+015/.42)22.1/10**(/0601$01242'/+*'4*(01232,..$-2503*25452.*425/3153512.05/2.$23/4-)///0.-135*-*//.4,0*++1-1/#.033652/0301-,16522653+04/+660//-+),3+-)+--6,.24,00,6/)220-)/)/,-)/00-,,,3/*012/-/())#)+.1+0232(2 @rCer/2160/1912_57_CCS ATGGGCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAGGTAACGCCTGCGGAGAAACTGCAAAGATGCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCCTCGGCGGCCGGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCCTCTAACACTCATCTTCAGAAGACTGGGACTGCTGAGATGTCCTCTATTCTTGAAGAGCGTATTCTTGGAGCTGATATCTCTGTTGACCTTGAAGAAACTGGGCGTGTCTTAAGTATTGGTGATGGTATTGCCCGCGTACATGGGCTGAGAATGTTCAGGCAGAAGAAATGGTAGAGTTTTCTTCAGGCTTAAAGGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGAGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGGTCCAATTGGTTCCAAGACCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCAGTGCGGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCAATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCTGCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCTGTTGCTGCGCCGTCCCCCTGGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCGATTGTTGGAGAGAGCAGCCAAAATGAACGATGCTTTTGGTGGTGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTTCCATCACTGACGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTGTCTGTGTCTCGTGTTGGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTTGGTTCTGACCTCGATGCTGCCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGCAGTATTCTCCCATGGCTATTGAAGAACAAGTGGCTGTTATCTATGCGGGTGTAAGGGCTATCTTGATAAACTGGAGCCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACCAAGCCCTGTTGGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAAGTTCTTGGCTGGATTTGAAGCCTAAACTCCTGTGGATTCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAAATAAAGTTCCATAATGTG + KKKK&KKKKKKKJKKCKKKKKKKK2KFKKIKJKKKBKKKKJKJHEKKAKKK>KKKKDKKKKKKKKKKKFKKJKJKKJKKKKKKKKKKIKKKKKK?K6JKK6KK0IKKJK@KKK9KKK>KK6G?KEJKKKIKIKKKKKKKIKKKKKJKK@KKKKJKKK7KKKKKKJKKKIKJK@K;KKJKKKK4KDKKIHK7KKKIKKKKKKKKKKKKKK.KKKKKKKK>KKKKK>KEJKKIKKKKKKKKKKKHJKKKKFKJKKKKKKHKKJKKKKKGKKK3KKKKKKKKKKKKK9JKKKKKKKKKKJIKKK&KKKKJ6JKKGKKKKK9IKKKKKKKKKKKKKK;KKKKKHKK+KKKKKKBKKKKDKKKKFKKKKKKKKKJKKKKKHKKKJKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKIKKK?KGKKKK?KKKKKKKK=KKKKBKIKKKKKKKKKKKKKIKJKKKJKEKKKKJKGKKKKHKK)KKKKHKKKKHKKKKKKKKKKHKKKJKKKKKKKKKKKKKKKK8KKFKKKKKDKHKDKKIKK2IKKK?KKKKKKKJKKKKKKKKKKKK,K:KKKKKKKKFKKKKKKKKKKKKKKKK8KKKIKKKKKKKKKKKKKKKKKKKEHKKKKKKKKKKKKK/KK/KKKJK+KKKKKIKKKKKKKKKKKKKKKJKKKKBKKKKEKKKKKKKKKKFKKKGK;KKKKK>KKKKKKKKKKKKKKKKKKKJKJKKKKJKKKKIKKKKKKKKCKKKKKKKKKKKFKKHKKJKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKHKKKKKKKKKKKKK-KKKIKEDDGFDDB7CD2DD7@@EDD@E+A@=AC4ABE/AFA@1@FEEEGDBD=6C=B?85>/<=CFEGAFBD<>:>?=DD>@E7C>9>B>BCD@ED>E=@B:?AEAFFEEB>F>?9ABBAE?A7@GBA?:=;:?>>A,AB?D=B:7;<69<55C=A>AG?BB9F>'CDCC=87?>@@A>B=7DAB<@6AA@ECBB>02:?@;?>?B>BFGB?C73@978@<;58A?='538B>BA<>6==FCCA;FBC>;<=A=B-DFCD70=>@=9AFEBAAD:FC@FE>FCACCE?BDFE@@@=B><>7A66=B1:?;0@=C<:BC>A*B=<;6=59,1@?DDB>B<;@<19CC<84F@?8'7=1BEC?@;<8:B@B=<5>?B=2B6>;=>98DA=58AD?DEEC@FA@FFG=??2=64>>C=4DA7C@;>A=?C=ADCFA;@D@@G;<:@C5AFE@DCA??9DCGBDBA2@ABD?CEGFECB?A?>FCCCAE>A75?7?F?DF<:GAFE<@>B7>5AED>>B:1=CB:>BDBBCFE?BF??8D?AEAA6A?BDCED?>A7B:=<<784A99EA@?>@:@7C505:7?4>@>8?C3;ECBD?FCGFF=CE@==B;A?C:D7G=E;DD:CFB?D@?AA>B:D?4AG==B;?E?EDB573:>(??B,=A9<7-6@@B69A=>?4::961=A;?,>7;>7>>B<=7??<6A:A1@;=3=DEC@>BBBC7>?BD@?>8@A?D59,A?<:;?A>??4:9DCDAGBCAB>D>E;@B<7<<9:AABA=8:>B4DFA@?>>.:>?C3BBA69@>:A93@:<5D>/B/=AEE?A6?BEDEFF0BC:D=BD;BAE@C>8<>BE3B:@9BC@BAD?A=B/;8B;ACCCA2AECD2=?>>@EA;BDA:7>9;9<@DB9@A=<8/748;;08>0>C9HIDD>AGHD?DDC<:JJ@IGG;>FHIG:@C$9?@F:DEB:@9;2=/B,71DE>-B@?DAED@C>D7CDBFA=@=;A25,4:61?@:?8CDF>AEDEC4@@=?E?@>DEED4D>FBB7:ACC?ABAE?F5EB>D;C6CE@<745?3AFD1A::F>CED8EEE@DE:CCDC5@@AF?G>GEE6CG=CE2BB8E?BB6EA@FFFC>DBG=FD8ED;?E?===A<@?2CA8<>CB:?;8@<>7:*?CB;9FED@*C>@AFGG?>B;?95=>;E6E=B??7?19E(B;5@:EF?FB95:>DBG?AD=>EEDB=BE?1D5FB?A>:A;CB=>><ABA>GEA>;>A@=:7=2@91=@D>C7;:?:C:D@?FGG6GDEEF;AE@3<<8GD?:>?2@-?==?:@C*27=5>1=@C?BFF7ED9<7?CBE@?;=@CAEFADACCGDFD=GCFBE57EACE>?>>>0=BE@?>26>:1;3:BB>ECFEDEBA2'>:@?48/7:'*'+26440+00/9,7828;;9<;6<74::9%74597+/:53562<58.8/%3,76831*,..03,/4=:262+32%+--2631125.72(3/3;3488<:682%6:4;/3-55.$170765.-,0520+-0-)*147:775672-894/,7978<=57606.355()&.0$%3587<;>;-+15=:70)%05572-5151(5.31+047(5'-6*0,'33997698(/09:287;4738**059.26=>150/-65.386:>956-4'/'3+885/03265'20<;84:64')541..&722191818::5=1.*27-8'53%043/+/8:>-3134-*0+1;:8859:<<609-)+2(/1262<070)144<;277=62.-1507861=69264:853-36:1796-49'247-;.968.6061-86323+240456;>7264<27(/184(:5*3:0780<8)7935<=81+(5483293)16897+2,27/-/1+7;3;599588=92>03179%5=497>274&4<9878&11799:1/60;3=8-*8659%*+41346+1/3=546574=7)097=7159'/(%*21-+0.>:?972753002:74+61095=;6.7>489;83.0%5*956657510(2/-79=;6;8*5>>=567)/.%//4//.-&01)3/&*3269?8418/3:5481633*04278%5086==>955<25:(3/(.0,55/*/%%*%3;60*1,86'4-7.26>*9/&365&04+7/74+.&*.+<352166+:>29/2/,+.1.3/7(0+..*.-)'6,.82-*53245/0;7%08083)5&701905250'(1.*55:;64=216121*.,3192+.0;3*1&$&668;/2+/6'8&)8>73<6,76;6/3;=449841%9942.36=81358;-2)..295-%/40+448661)'0///963750623<7,76%7.*20)1)%'(**-.',).0'.(&/052,0.974098)99:;75/).88<<::2:64=499869759986714+2'*/1=41.(0./.'505+,2304/3686ABB9@@<*=&:008<05;A=/960576B<=C=273:33',+$.;39<;78:9534:;><3;<:B>8><99205@98=:/659966@>9?==C?:AA8?AAB?0;==9BBC<65><=:026,*&&189/<96==5;-.0?1?.575=:<=<+A-5)7==;412*67?:7@;5?=79=9500:073=693+=?2<<;=)7;<:37?@<9@:%921;.=356:;:/696<'8;4=+4&76;*1/,-352461333-+8>:6A&<;>=80AA?=>@6=99A?7>?:6/6=9A7<871+8;:73:B<;9=?=)0628><:<697:@68;3>=78<=1924129;2<0:6)$69,.2+754:4-:>5=72;:,74)97/;/6>8-3507:58-943,+/>>6=&8:93)90/;)40;8/>;0;?836476<737<;><%-:;4;$+-.-2/6&7457:64<9;<>%=69?7=86/:8<;/6=?%;;<6;+?D/B?;?50;BB@>@3A)AAC9??>CD5EA4<9;4:&34+6>?8<:CB=EGB+=@7A>A;AED2>DB=A@=C1@=41,<=:6@DF;9=B.;1?3=;=C:-B2>EA;B:7:?:%.39?>2:489;87@:0A88696(24BB:;D79088:4:*<0+81684'*/:>878,(03@?=E67;A:?F:;;33:258//50%4=?,-0?;C@C<6A=>=???==?E4D3>=<9B4;>93$655:9:D69>/75:?993/9@<<@C:6<91?=4@D52579>E;C88=58?>:4<,-794:B'586;@>9&:CAG53;;656:<85://2:93@5=8-:;92$0/:9B7/):;7:-3-,'2<2.9<8;<:3>7AE??774,0/#>>+'84><;B=<@C=?B792:8:4?BD9?9;E@9>@>9@=@D/>>=6(5355275&670-<270/*9.97,7?7'):+&/(2783@;A2=1,1637;6*'%<62;927;73?AF8AC;A2>:>9B9*7:<;?@A4;6@::67:6&<<26=;1E3'9<9/:E>6:3;.:3757@3?=:5&/<=A.2+.+0?;0??8:4-;@6*0959,7;;614'26<<5B=@8%357,C>/:=88=C8A<0(;344,4+9?< @rCer/2165/1097_55_CCS CCAGATGAGGTGGCATTCCTGCGGAGCAACCACGAGGAGGAGTGGCCGACCTTCTGGCCAGATCCAGCATCACACATCACGGTGGAGCGCAAAGACTACCTGAAGACAGACATCTCTACGGCGCTGAAGGAAATCCGCTCCAGCTCGATGCCACTCCGACCAGAATATGCACCAGGCCGAAGAGTGGTTCAAATGCCGCTACGCCAAGCTCACCGAGGCGGCAGAGCAGAACAAGGAGGCCATCCGCTCCGCCAAGGAAGAGATCGCCGAGTACCGGCGCCATTGCAGTCCAAGAGCATCGAGCTAGAGTCGGTGCGCGCACAAGGAGTCCCTGGAGCGGCAGCTCAGCGACATCGAGGAGCGCCACACCACGACTCAGCAGCTACCAGACACCATCCAGCAGCTGGAAAATGAGCTTCGGGCACAAAGTGGGAAATGGCTCGTCATTTGCGCGAATACCAGACCTCCTCAACGTCAAGATGGCTCTGATATAGAAATCGCTGCGTACAGAAAACTCCTGGAGGTGAAGAGACGAGATTTAGCACATTTGCAGGAACATCACTGGCCACTGTACACACACGACAGCCTCAGTCACAATATCCAGTAAGATTCAGAAACCAAGTGGAAGCTCCCAAGCTCAAGTCAACACAAATTTGTTGAGGAGATCATAGGGAAACCAAAGTGGAGGTGAGAAGTCAGAAATGGAAGGCCCTGACAGCCATTACAGAAGGAATTGGCCGTTTCATGAAGAAAGAGGAAGAAGCAGCAGAAGAAAAGGGAGAGGAGCCAGAAGCTGAAGAAGAAGTAGCTGCAAAAAGTCTCCAGTGAAACCAACTGCACCTGAAGTTAAGAAGAGGAAGAGGGGGAAAAGGAGGAAGAGGAAGGCCAGGAAGAAGAAGAGAAGAAGAAGATGAGGGAGCTAAGTCAGACCAAGCCGAAGAGGGAGGATCCGAGAAGGAAGGCTCTAGTGAAAAGAGGAAAGGTGAGCAGGAAGAAGGAGAAACAGAGGCTGAAGGTGAAGCAGAGGAAGCCGAAGCTAAAG 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ATGGGGCCGTCCCACTCTGCCCTGTTGCTGTCGCGCCGCCGCTGGCTGCTGTCCCTGGATCCCTACCATGGAGAAGACCATCGAAGATCCCCCACATCAGCTGTCTTGCTGGATCACTGTCATTTCTCTCAGGTCATCTTTAACAGTGTGGAGAAGTTCTACATCCCTGGAGGGGACGTCACATGTCGTTATACTTCACCCAGAATTTCATCCCTCGTCAAAAGGATTGGATTGGCATCTTTAGAGTGGGATGGAAGACAGTCCGTGAGTATTACACCTTCATGTGGGTTACTTTGCCCAGTGACCTAAACAACAAATCAGCTAAACAGCAGGAAGTCCAATTCAAAGCTTACTACCTGCCCAAGGATGATGAGTATTACCAGTTCTGCTATGTGGATCAGGATGGCGTGGTCCGGGGAGCAAGTATTCCTTTCCAGTTCCGTCCAGAAAATGAGGAAGACATCCTGGTTGTTACCACTCAGGAGGAGCTAGAAACCCTACAGAGCATCAATAAGAAGTTGGAACTGAAAGTGAAAGAACAGAAGGACTATTGGGAGACAGAGTTGCTTCAACTGAAAGAACAAAACCAGAAGATGTCCTCAGAAAATGAGAAGATGGGAATCAGAGTGGATCAGCTTCAGGCCCAGTTGTCAACTCAAGAGAAAGAAATGGAGAAGCTTGTTCAGGGAGATCAAGATAAGACAGAGCAGTTAGAGCACCTGAAAAAGGAAAATGGCCACCTCTTTCTCAGTTTAACTGAACAGAGGAAGGACCAGAAGAAGCTCGAGCAGACAGTGGAGGAAATGAAGCAGAATGAAACTACGGCAATGAAGAAACAACAGGAATTAATGGATGAAAACTTTGACCTGTCAAGAAGACTGAGTGAGAAGAAAATGATATATAATGCTCTGCAGAGAGAGAAAGAGAGATTGGAAGGAGAAAATGATGTATCCAAGAAAGTTCTTCCCCAGCCAGCTCTCCATCAAGAAATGCCCTATCTGCAAAGCAGATGATATTTGTGATCACACCTTGGAGCAACAGCAGATGCAGGCCCTTTGTTTGAATTGTCCAATTTGTGACAAGATCTTCCCAGCTACAGAGAAGCAGATCTTTGAAGACCATGTGTTCTGCCACTCTCTCTGAGTGTCCCAACCTCCTGGATGTATACAGAGATTTTATAGAGTAGAACCTGTAGCTTCTGCCATGAGTTATATGAGTCTAGATCCTGCCTAACCCGAAATTATTAGGGATTTACTCAGCCCTGCTGCCACTAACAGCGGAGTTGTGTCACTGATCTGAAGGTCACTGTTAAGGACTTCTGCTGCCATCCTTGTGGGTTGCTACCTTTAAGTCACATAACTCTAGCTGTATCATCCTCTCACCTATCATTCTTCCGAGGGTCTCAGTACAAGGGCCCTGGGATGGAGCCAACCTGGGTATTCACAACAGGCCTGACTTGATACTAAGTGATTGGTTTTCCTAGTTGTCCCACTGCCATTCAAAGTCAGCCCTTGAGTGTATTTGTTCTCAGTCCTAACCCTGGGGCCAGAGATTGGTCCGAGGTTGAGAATTCTTCCACCTCATCCTCGGTGTTGCTTTCTCCAAATGATTGCGTTAGACTAGCCAAAAATGCCGTGGCAAAGAGCTCAGAAGTCCAGTTTGGATACCAAAGGTTTCTCATGTTAATTTCTCAGCCCCCAAAGAAGCATCTTACTCCTGAACCTTAGACAGGAAGTATTATTTCAGTCACAGAAAGCTTTTCTGGGTACCTCTGGTTAGCACTTTCTACTCTCTGATATTTCCTATGTACATAGCTTGTATTGTTGTAAATCCTTTCTTAATGGTTAAATACGGATTGTTAGCAACT + B&=FEEGIHF4HI@>8DDG8C?CHHDI<1GJG2HD@;HFHBIJ;GHIEH5FFFAJGHHH=EGFF)GFGB?BIGFE==BE@D>IEEHBI:BDAHIHDBC4FDFGBGFIEFBABHHDIIA9EIA@JJIHH?-JJID@H@HG:BEBEGGEHFE?'6EFF8FDA=0G/CE@=;-EGC?IGI?IBDCD9AG>E?@<=EAE?DBHIF7DIH:FE=G>J0=<7=@ABCGECFGF@8?F;?9:@?ID@=BF9EH@HFB0GHDBHGFI>DF:G>GCJEBHH0EDEGEDEA9BHG>IHEGE@BEGGBFGE?BDF>FDEEA>@:?I>CHEHIDHCFFFHEIGAG>IBGH@DF5HGEAA@H9FHEJHB;>H?9F2?5G=??CIJE9FBEE6G8FEGCAD?>C:BB;GFHCGF0GII@FIICDC3;C@/?9D@F1DIDEC;AAGDIBCDIA2@0A??<>FGCE:EG@IBHEECCHIEHHEFGG@EGIGE7GEJEG9=HHA>HGBIII@FHFFAIDCIGIFGJDFJBIIDFEIDDIE>H>D4DDDADF=EHCGGA;AA7EC;6EAADGGHAJ>IIGHFFG*GHFB2DGEHFGIHC=7I=BFIABCF7HHG@DDIA9IIIDE687DGDD?GDECFFEIIIHHIFA>HAGIGFIHEEHDIBH0?7;4FECBCAIIEBGAJFII>IJEEJGA?-EFBFJGB.;CEG@>BFBH@JGFDIJIJIEI?>DGB;F=HGDHICFJICGDEG8HDACAFGGEHAJIHIIHH><<F4IFAGFF@FHFCIJFHFABAADADB@EE@;GHF@B?&5CIAIH7>CDFH9D9HE5CGF7HC6@@C@?>C7B;BD'@=;ABE?G@=GH?EIGFAJJ6GFEIEGII?EGID>FEHEI7EIE>IAGJC2IGD7H?BBGDCEIJB@FFEHJ,EE=ABH?IH7F3B>5ECA:AFIE@2CHF3GF=2EG@F5CCIH:E:@>;56DADFAG?E.GGECD4,?6D=9+5:AB8BBEC8ECEA=?C@?9FF9<;CE5D2@A:?+::5-95=A9A;>/<<357:>5CCC@.:9>=CCBCAB6=<:>8@>=6=<>:?9:>>2=>6<:7>@C>2==A@@CB@ABB,@AAB2AA@@@4A>@>2>4<;1>@CB>?>;8;>@;6:@=3747534+5?:@BAA@3@@B9@CCBAAACB<>5;>9>CC>8C>C?=;AA @rCer/2168/25_1546_CCS ATGGGGTCTATCGCGCCAGTTCCTCAGCCTGAGTGCTGTGAAGGTGACAGCCTGAGGTGACCCAGCTGGCCCCCGCGATGCTGGCAGCACGGCGGCTGCTCGGCGGGTCGCTCCCCTCTCGGGTATCTGTGCGTTTCAGCGGCGACACGACAGCACCCAAGAAAACCTCATTTGGCTCGCTGAAGGATGAAGACCGGATCTTCACCAACCTGTACGGCCGCCATGACTGGAGGCTGAAAGGTGCCTGAGTCGAGGTGACTGGTACAAGACAAAAGAGATCCTGCTGAAGGGGCCCGATTGGATCCTGGGTGAGATCAAGACATCGGGTTTGCGGGGCCGTGGAGGCGCTGGCTTCCCCACTGGCCTCAAGTGGAGCTTCATGAATAAGCCTCAGATGGCAGGCCCAAGTATCTGGTGGTGAACGCAGACGAGGGAGCCAGGCACCTGCAAGGACCGGGAGATCATACGCCATGATCCTCACAAGCTGGTGGAAGGCTGCCTGGTTGGGGGCGGGCCATGGGCGCCCGCGCCGCCTATATCTACATCCGAGGGGATTCTACAATGAGGCCTCCAATCTGCAGGTGCCATCCGAGAGGCTATGAGGCAGGTCTGATTGGCAAGAATGCCTGTGGATCTGGCTATGATTTGACGTGTTTGTGTGCGCGGGGCTGGGCCTACATCTGGAGAGGAGACAGCGCTCATCGAGTCCATCGAGGGCAAGCAGGGCAAGCCCGCCTGAAGCCCCCTTCCCTGCAGACGTGGGAGTGTTTGGCTGCCCGACAACTGTGGCCAACGTGGAGACAGTGGCAGTGTCCCCCACCATCTGCCGCCGTGGGGGCACCTGGTTTGCTGGCTTTGGCAGAGAGCGCAACTCAGGCACCAAACTATTCAACATCTCTGGCCATGTCAACCACCCTTGCACTGTGGAGGAGGAGATGTCTGTGCCCTTGAAAGAACTGATTGAGAAGCATGCTGGGGTGTCACGGGCGGCTGGGACAACCTCCTTGCGTGATTCCTGGTGGCTCGTCTACTCCACTGATCCCAAGTCTGTGTGTGAGACGGTGCTGATGGACTTCGACGCGCTGGTGCAGGCACAGACAGGCTTGGGCACAGCTGCGGTGATCGTCATGGACCGCTCGACGGACATCGTGAAAGCCATCGCCCGCCTCATTGAGTTCTATAAGCACGAGAGCTGTGGCCAGTGCACCCCATGCCGCGAGGGTGTGGACTGGATGAACAAGGTGATGGCTCGTTTCGTGAGGGGGACGCCCGGCCGGCCGAGATTGACTCCCTGTGGGAGATCAGCAAGCAGATAGAAGGCCACACCATTTGTGCTCTGGGTGACGGGGCTGCCTGGCCTGTGCAGGGTCTGATCCGCCACTTTCGGCCGGAGCTTGAGGAACGGATGCAGCGGTTTGCCCAGCAGCATCAGGCCCGCAGGCTGCCTCTTAGCCCACCACCCTGGCCTGCTGTCCTGTGTCTGTCGTCTGGAATGCTGGACAATAAAGCGAGTGCTGCCAC + >72@AB8:?@E@EF=(;:<5DBBCD@@7F>4926?:@?DE:D4;E;9'>:8@(<==<3<.5*A88BB;CC0BEC?GCDC?5CEF?2C998588.;<*<=@;E;=/EEE<<1;-=B@=6<@CAD@=9C@>36@9B:3)@958:,7=E,6<:7;FGDGED??=>@1B)@D>;@AFA-D1C6<@4A76?F1A+A15<9@(>4<=,:/<5B<@8D7/>:>:-?<8B'.(8/87(8>7@3A?6=>>6E8@<59@7:2BC98=??;4B8>;1>:C/BBB/F>D?.;=>:?7;@/DE9@@D84:89@<09??)?:B.96>(;9>39;2C9<4;2BC8B(<@BC@;6?>DED&C0A3?C98<9@47C,DB@D6&DBC?41B'=A;'@%?@?GA;E?B54F@+?>><@;A=:9%8:8%4FB5C7D7DB@E>C0=9-6)6;<6A7&2:1=15@AB==C3C6>891C9-+7B74B6G7>99=);:6@5='@540-(79+52/,;5>6)::<457D:2=86><>3E?626.;=:.>A*$9?8@BB8;6?A->1A?;F*=992CDE16($57BB=.97FC98-/29@4FCA7?JCD6:8IH9=>B8(@@A:4?4<@A;3GCA1H@B;3FBH;@8,C=..B>A;F2$=89;,=.ECAAGE>(>9>5DG>+4>5HI>G?6E;EJH2@4A;<=66B7G5IA>?;F=AABCEE5B>?8;9;2E:C@?@C8DA@9?1HC@B?<5G?)75G:42D2A@8?G9B<;@@DCDD5BAH7B?A5=89:85>>7>D=:+8A?<;HAA=C?=?5H839)8>=DFD+7@E@=E;&:>=DA/EB@=I?@>;+8/%8?-C?D?J:B:>*87@<07;<DEC1A7?9749)<<2)1?0843?;?:5%;=8-B&=3=EA7C2<=;=13B@A9??@>:52&A;'27>C=A11;>:>%:7C2425<6='<>@DF?DB>@@D;'>>>BA9<3AD59C@6099?A4A@?:92<8=:<@;@;B39@:@28417CE8@BB;A)AA=-B=3<:A@<49B?5(=,?34<:>;D8B<:@?1@=?=;;:;80?:=6:?9BA8:4&::53/$?;=73>;;=39<3;=;=<9:5@.:AC4<@@A?@>(62>?841)?='1/68;;B>D=<:>;?@>.C>2722@>?7@B?B;EFA=:B7?1=3)44>4+87:7;;C@>;8<=>?:-=AA8<=:?E@+=C2.4?509B:8B?D-E<:8:(98>3:33CB?5C2@B@.;)$8A1@1/:4=8=296;+8=/-1*$)*6;B0=B=CCB==A;87<;A68;*,>6& @rCer/2169/1678_59_CCS ATGGGGAGTGCGTTACTTACCTCGACTCTTAGCTTGTCGGGGACGGTAACCGGGACCCGGTGTCTGCTCCTTCCGCCTTCGCCTCCTAATCCCTAACCACTATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGTCAGATGCCAAGTGACAAGACCATTGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCATGTGCCCCGGGCCGTGTTTGTAGACTTGGAACCCACGGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGTACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCGCCCAGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCGCATCCACTTCCCTCTGGCCACATACGCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGATGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTTCAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCCGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACTTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTATGTGGTGAGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAATTATCCATTCCTTTTGGCACTGCAGCATGTCATGCTCCCAGGATTTCAGCTTCAGCTTAGCTGACAGACATTAAAGCTTTCTGGTTAGATTGTTTTCACTTGGTGATCATGTCTTTTCCATGTGTACCTATAATATTTTTCCATCGTGTCTCAAAGTAAAGTCATTAAC + KIIFD%G;JJ;CJDCKK8JK9KHJ?IJBJ6KI;KJJKKKKKBKIKKJKGKFCK9JIK6KIKHKKKIKKIEKKK>KKJKJKKKEJKKHKK@KK>JKKK7KKKKKKKKKKKKKKKKKKKKFKKKJKEKKJKKK?KKKKHKHGKIKDKKKKJKKKKIKKKDKKK@JKKJKK;KKKKKKIKKKKK@KKKKKKKKKKFKKKKKKEKKKKGK8KKKKKKKKHKKIKJKKKKKKK8JKKKEKKKJKKKKKKKKK;KKJK;KIKKKKKKKKKJKEKKKKKKKKK-JKKKJKKKKKKKKKAKKKKK@KJ5JCKKKKKKKKKKKKK;KKKKKGKFKKKEKKKKKKKKK,IKKHKKK&KEKKKIKBKKKK1KJIKKKJKK>KKKJJKKKKKKKJKKKKKKKKKKKGKKKKK'KK?KKKKKK=KKKKKKKKKKKKKKKKKKKKKK'KKJJKJ&I.KKIKKKKKKKKKKJKKIKHKKK%KKGKAKKKCKKKHKKJJ)KKD?IEEKFKKH;HKFKKKKKKKKJKKKKKKKKKKKKKKFKKJKKK:KKKK5KHKKKKKKKKKKKKKKJKKJKKKKKKKKKKJKHKIJKKKKKKCKGKFHJKKIJKJKKKKKJKAKKKKGKKJKGKBKKKKIH>JBKHJKKGKKKJJGJKHKK;KKJFKKKGKKKKGKKKKBKKKKKKKKKKKKKKEKIKKGK/KJKKKK>K;KFKKFKFKJ4CIKKK$KJJKKJKBKAKK5IKKKJK;KJKKKKKKK%KKBKKKIIKJKKKKKKKKIKK?KKKKKJKKGKJKKKKAKJKKKJKKGAIJKIKJ&KKKKJKEKKKKJEAJKKKKKKKJK=KHJKKKKKKKHKKKJKKKKKKKKCKHKKKKKJHIKKKK1KKKKKJKK9KKKDIKKK=KJKJJKKKKKKIKAKKJKKGKKJKJJKKFKKIJKGKKKKKIKKKKJIKEKKKHKKKKKKKKKKFKKKJKK:KIKJJKKKBIKKKK=KJKKGKKHJK+KEKFKJKBFKKKKKKKKKKK@KKKCKKJJKKEKKKIKKKK+KKKKJKKKKKKKKKKKKKKJKDKKKJKKIKKKKKBKJKKKKKKIJKKIKJKIKKKKKK:KKKKKK:KKKKKJKK@KKHKJKHJJKKJGKIK8EK5IKKKKIHKHGJHKIKGKKKKFJKKKKJGKJJGK>KKFCKKKGKKKKIKJIHKIIKKKKJJKKKK2KJKJKKKAKHKJFE7JKKKBHKKJKKKKK @rCer/2170/1804_56_CCS ATGGGGGAGACCGCAGAGCTCTGGGTTGTGGAAGAGGTGGCCGTGCACTGTCATCAGTATGCAGCGATTGCTCTTTCCGCCCTTTAGGGCCTTGAAGGGGAGGCAGTGTCTGCAGCTCCTGGCTCCTAGGGCAGCGCCTAGAGCACAGTGTGATTGCATCAGGCGCCCTTTGAGGCCAGGGCAATACAGCACCATCTCTGAAGTAGCTTTGCAATCTGGAAGGGGTACAGTGTCTCTTCCCTCAAAGGCTGCCGAGCAGGTGGTGGGCCGATGGCTCCTGGTCTGCAGTGGAACAGTGGCTGGAGCAGTTATTCTTGGTGGAGTAACTAGGCTGACAGAGTCTGGCCTCTCGATGGTAGATTGGCATTTAATAAAGGAGATGAAGCCACCTACAAGCCAAGAGGAATGGGAAGCAGAATTCCAAAGATACCAGCAATTTCCAGAATTTAAAATCTTGAATCATGATATGACACTGACAGAATTCAAGTTCATCTGGTACATGGAGTACTCACACCGAATGTGGGGTCGCCTTGTAGGCCTTTGCGTACATCCTGCCTGCTGCCTACTTTTGGAGAAAGGGCTGGCTCAGCCGTGGCATGAAAGGACGTGTTCTTGCCCTCTGTGGCCTCGTCTGCTTCCAGGGTCTCTTGGGATGGTATATGGTGAAAAGCGGACTAGAAGAAAAAACCAGACTCCCATGACATCCCTCGGGTCAGTCAGTACCGCCTCGCTGCCCACCTGGGATCAGCCCTGGTTCTTTATTGTGCCAGCTTATGGACCTCGCTCTCACTGCTGCTTCCTCCGCACAAGTTGCCTGAAACCCGTGCACTCTTATGGTTGAGACGATTTGCTCATGGAACAGCAGGTCTGGTGTTCCTTACGGCTCTCTCAGGGGCTTTTGTGGCAGGGCTAGATGCTGGGCTTGTTTACAACTCCTTTCCCAAAATGGGAGAATCCTGGATCCCAGAGGACCTCTTTACCTTCTCCCCGATCCTGAGGAATGTTTTTGAGAATCCCACCACGGTGCAGTTTGATCACCGGATTCTGGGAATCACTTCAGTCACTGCCATTACAGTGCTCTACTTCCTCTCTCGGAGAATTCCCCTTCCTAGAAGGACCAAGATGGCAGCAGTGACTCTGCTGGCTTTGGCGTATACACAGGTGGGCTTGGGCATCAGCACGCTGCTGATGTACGTCCCAACTCCTCTGGCCGCCACTCACCAGTCAGGCTCCTTGGCTTTGCTCACTGGTGCTCTTTGGCTGATGAATGAACTCCGAAGAGTCCCAAAATGATTCTTAGAGGACCAGCTTCTTGGGACTGTGACTGCTTTTGAGAGCTCTTCAGAGATCCTAAGAACTTGGGCTTTTCTACGAGATGACCTTGACATACCCAGTGGTTTCCAAATGGTCAACTTACTTAAAAATCTTTTCCTGTTTTGAGATAGTCACTGGATCAAGAATGCATTAAGTGTGGTTACCCTAAAGGTTCCCTGTAAATCTGCTTTTCATGTTGAAAATCAGTTTTAATGTAGAGAAAGAAATGTCTGCCATTTACTGCCTAACAGGCTTTGTGTCAGGTTTTTCAGTGTTGGCAAGCTCTTCGTTCTACATGGATAATTTCTGTCTTCTTGTTCTCCTGAGTCCTTAATTCTGCCTAAATAGAATTTCTTTATGATCTTAAGTTTACTTCCATTAGGTGAAGATTGAAAGGATAGGATGGACATACCCAAAGTAGCCAGCTGGTCTTC + =JGHII:HJHGDFJC9DIGAAGFKJIJCG?GCDAIE8@73CFFD3?EDHBJBDECEDJFE?>B10=B==?;AE4ED4A;DD8=38E>CD1AF?9GIJGCB=:>FCGGAD:FFJHJD;CCCCHCACHFJDGD8;F@@F?HAHJ?AAEF8IFB8IDDGHEGGD?FGJEBAGCC??D4@<8HHEIDJF@IAG8G8FKIGGEFDHIGH3IE=;KEBA@=EGGCH:HFJ>B9HIKFIAFGG?G6JEKAKIAAD;7F:BGDA:6D6C9DGHCHF6585)3;5?98.5AD?0>H>D9?:<6-,9%A=769CA5D8D?FC=CFDIKF?@GA7C0I>FCCE>=E=DGKGJ?HBD>>=BI8CBBDG<.HEJHFG=GF=6CHCDH?7:IJGHJHIF:9AI@?A4>FA65:A==F?9=B3HFF>F@;DGF=@IIKJ>,@A??C+2?=D@;@:HD@ICIKDA:GJG@ADHCIC>>B@IHG<:AHEB:@@35C?AGFI?;7@2AEAH@?EBGB4EG5:CDGGAJJA@FEE9759:7,<=78A:AFED=@H1A4A=?<8C8G??ABC9A8BGGICD=8?5GB3G@ACI@5B=HA*>AI=IGJG;FIB@F?CFCCF@DC;DG<>?>IEIFKJGH=BIEGCE.HH@<8AG6E?DDE=<2<<=:>FD>@==CGAE8BI8?AF@6DE8<@CIDC<6DGCBC??)?;E<8AGB7CDCGEHC@>C@??3E?FHA@G?DEF@C8C?FIF@I>B=>:AD=DF9@EG?IBGDG@<:9DH6HD=AF96D>BG4A:>FAE4>4GC==E96A<9:E5F=@@D@5BA><5?>4BAJ<>A=>;??F@A>H@AG87(A-5C1::4B?A9?;=8=>2@8/>8=E<@AA1E<@.7EE>@EE9?=CF8EF@GG@?>4B=H@9A>3,B;>HBFDD>94B>>0@DI@FAEDA?>?FJBFC;<@1C59DC<:BG@5<7;=:@7=AE;@D7B<=D7C@CD:@CB<;>%=E<6;;0=<@@,8CACB-;<9>7>A'CCD>5;8@DB==?49?@B=4D0=@:?E?C=F@?A>:9+G@?C6D6D::4@A97D@D@6-@EC=BAAEBF?C>;<=.EBC?>3;E7=3-?;FE=>=@?@B1>AGEEB>EE9C;8A?54?BF7B>@??D;A@@:==A6D5:B9AC@<3B9A=D3>EEA==C>@B3.8?9A@>A48='B@,A?AC=70>D<@EE?@'A @rCer/2172/25_1483_CCS ATGGGATAGGAAGCTTGCTTCAAGCAGTGACTTTGGATTGAGTTTTGAGAAATTCAAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGATCGTGTCCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTCTAATCGTGGAATTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAATTCCTTATGGTTAACTACTCCCTACAAACTCCTACTACATTGTATAGATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGATAGATATGTGAAGATACTCCCAACTGTGGAATGGCAGTACAGGTAACTTCAGGAAATGGCTCGGGTTAATTCTCAAAACACAAATTGTTGCTGGCCGGCACGGTGACTCATGCCTGTAATCTCAGCAATTTGGGAGGCAGAGGTGGAAGGATCGCCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACATCAGGAGACCCCGTCTCTACAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGGTATGATTGCACCACTGTACTCCTGCCTAAAAAAATAAAACATAAATAAAATGTCCCAATAGTCCATCAAGGCTTTGATCACTTGGGGAGTTCTTCGTAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATACAGATAATACCCCCCCACACACCTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCAGTCTGTGGTATCCCTGAAATTAAGGGATAACATAAGCAGGAATTGGGCCTTTCTGACATCGTCCTTAAGAGACAGGACTTTTTGAGTTTTTCCTCTGGGACCTACAGTGATGAGCGTTTAATGATTATCTCCTCCACTATAATCTCTTTAGGATGATTTTTTTAATCAAAAACCAGGGAATATCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGCCTGTTCAGGCACATGGTTTTCAACAAAGCCTGACTTTGACGTTCCTTGTCCTGAGGAGCACTTTCCAGGCACAGTTACAGCTTCCCCGCTGTATTTACAAGCCAAAATTGTGCAACTCTTCTGGATCATTTAATAAAGTAACAGATCTTTAAAAAACCCAAAACACCATTCTCCAATAGTCATGACAGATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTCAAGCCCCAGTCTGATTTTACAAGTAACTTTCAAACATGATGCTGCTGCCGAATGTACTTTTGTAAACTTAAAGATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGT + 1,*.2-66648;:4/856769.895337/675;9276(75:5%5422795;:(44-8627/88866*+16:::::78593:8785897567456&-8704-.1.03537731242,33798495173:=4?98=781;9=.:?839:)<653=07247(8777?>;=?>;>48088=?;8:>2;8;2:<9636=03(74?>10;77632747462;=:3;<8:=2<;2:7=67=53;9:>9:5;>>2:27:83=>934:65838;8.97/-+3/78:397>8477+;69:=55<77809>=>4,5:97;370;68>0:=874,6;=5;=>=/37=>6>3885652?>25:::269:<87>519+0;84:?>5;;=1.;4.(7<89-09994.66=7046<.*:6796=;>:?99?3:=:9==;:/4;5:>0;99;477-;9<>;2;6:688:7<90=:3:8=>;;=<059;>5:7;74:;=;';91579755<6(<99=75=<(;993/.$6'/17::<02<726679225151578+836::9;)3798<<:?51(7315684*16/6636366561,658699>669=9:==97:6895'=:<:<:3*9<738:/6>32:>;4=53=><>52<3=<897=7<=.<;9:9=2:<:7;/6=;:;=582>?;466787;<:9<:;>=(5797387:8:<:7,9;=>68;==;>9==?7;9:79/?+:;>><:9:<=;=474=<2479:8=896><'202486><49>?7;<797::?==<;?;696=<1749;;834322:907;=16=0829-2561.868><6<<6=967;8:1;9./'1877:5/>=>9=><77;:<:>4:3.467.2-6-78458<998:>3>>9<:6587>=943;4;97229?826:795<.==;;8<3<5=9?>;?7>609:4<9=<>9;>9;87?>;?<-:755&48:5583:9748-958967&449.5247,*55+8378253*146899:68+832524/7,/.(121342959893.533406)06839995473.6:5704.2566832-11881883:,69:5981.3295:63:50'1+2594:5..5'2+303.3&43%.+05(36534,4-%,3200.5-355/+%71503541+111855.7:4.2837735627152/2999896;956688::5:4,3233404(2-*63043318857;;9:28848184:8:5815388+786%-*1047549:664223994-55329'77447245749,449:4887:639151594.91-2261914985)8464-1,$-$)1143+./+,+*((-0,/4.440&6/77542342( @rCer/2173/893_55_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAAC + KKKKKKAKK)>KKJKK.EKKK2KKK)/K:JK5KKFKK8KJK/KKKKKKAKKJJKK/KHKKKKKHK2K5KKKJKKKKKKKIKKIKKKK?KKKKK$KKKKKKKKKK?KFKKDKKK6KKKHCKJKKHKJK;KKKIKKKKKKKIIIIK#DHKKKJKKKKKK5JKKKKKKGIKKKKHJKKJKKDKKKKKKKKKHKKKKKKJIFKIHKKIKKKKKKKKGKKK3KHKKKK.GGKKDKKKKK)KKHJKAKKKEGKK5KAKKKKKK'+%IKBKKKKKKHKKHIGKK?KKKKKKKAKKKKK5;>?=8;688663;=:123:91:=.83027=?>:39>998=<6:9:/8/;=;<<<7:<6<6145>??:>==732487)997:;/?>>>>876.9?:=1972;&3-8<:677<<<6544>==?::=:==>=<>>42<:2/74=;:8'62+28=4/::7:2435772;8>;=;:98?=9>=56==8=9725=7:9===;?9=49;58>98>4>>?8==996?8:78:?=9;=<0;=>:>8>;8:986:(<66:;,=>>:23<:<;?>=9;9<9-:9;?89<;5=?<>6>6>3:9?<2<=::>><6:9?==7=:>>><9==56677;.5>>99<923,<:83:>77,3===;>=?>?9=1<7>9:63<8>8===67<98,9=97=89;91?:95>9>59==7=;3;9=9::-?99?:<;5=<7:2=:67>:6<=?>94;99<==828;8<9794??96;.9>=:?9767=7<:969;8/;370<897:>,:;97=<9>2<8;/:>=>=9=:7<8?=>=:9<2;>=7<;49832?;?::9997:6>=9:<<39<>8:39:<+7739=<8?<=;3>.;6<:;<;:685::>?A:>4BC::;;89=@9;CA9<@7@;2=>@CA=?;==69=.8@==%@<=@B:A:<=@>C=:9A8-?;B:=:19.3721@51?<9>A?7?@=>77@B9A??>=;>0@B7<>BA<=?@%<@B?06A?6C?@88;:AA=5@C@8>;;?::4:6@@9>;@:<=>9-5:<@@06<6=<=B78+>@7=;<-?=>?>80-=1@:=<2==5=>A>C?@;92=;@=>A:269?B>14=39A/=>5<:9>=;7=AAA=>?A=&>.<2?=BB?@>C@389;5?/@?C<:?@A7:A9494:A@;=B?6A;=31<89:;=?7,=9<=<@>@8A=:A;?@?=@?8B??3?>B;=9::=';;2>9;7&9;@=?<@7:=6<16<;>-B@B:>?C=>7=AAA12>8>4;8<7<@AC?=A?@=<+/9@CC@?@;>=<26;=8:<2?>7?@:A15=@9;:6>7CA99?4=C>C?C>A:/:9877=9::=B=AB:A>?:=@@A8;@CAA::=>C>A>@B@@-A;A/<3:><5=)@<<<6>?8A=50<:49;>@<=0:=::@?=>?==;=87@@==9=7<+=&8B>2?5:6249*;?60:??A1<;?-?>;@8A>9<+2BAB?A3>4:4AB:B6>5:78@=@6@74>?*A:>8?>@;;<&?@B=='4;70:8BB=>66666?@:=+>=@C>>=;=/@<:>A9.8B:4?;?C@BAA??=<<=8A;>A=>(>CCA780)>;:==@=2<9+<8CA@92?@@+>7?8>:(78>(:B?=?@AA58;;29=<>=KKKKKKKKJKKJEK@KKJKKHIHKKKKAKHI=KKKK?KKKKK7KK=KKKJKECDKKKKKKKKIKKKKK?IKKJKKKKKKKHKKKKKKKKKKKKKK@KKKKKKKKKKKHKKKKKKKKKKHKK6KKKKKJKKKKKKKKKK@KKKK @rCer/2179/1851_60_CCS ATGGGGGGCAGTAGGTGTGGGGAGCCGGAGCGCATAGACCTCGCAGACTTCGCCGGCTTCACACTCACCTCGGTGTCTGCTGCACCCGCCGCTTCTTCTCCTAGGCCACGAGACCCAGCGGCTAGAAATTCACCATGTCTATTCTCAAGGTCCATGCCAGGGAAATCTTTGACTCTCGTGGGAATCCCACTGTTGAGGTTGATCTCTTCACCTCAAAAGGTCTCTTCAGAGCTGCTGTGCCCAGTGGTGCTTCAACTGGTATCTATGAGGCCCTAGAACTCCGGGACAATGATAAGACTCGCTATATGGGGAAGGGTGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGCGCCTGCCCTGGTTAGCAAGAAACTGAACGTCACAGAACAAGAGAAGATTGACAAACTGATGATCGAGATGGACGGAACAGAAAATAAATCTAAGTTTGGTGCGAACGCCATTCTGGGGTGTCCCTCGCCGTCTGCAAAGCTGGTGCTGTTGAGAAGGGGGTCCCCCTGTACCGCCACATCGCTGACTTGGCTGGCAACTCTGAAGTCATCCTGCCAGTCCCGGCTTTCAATGTCATCAATGGCGGTTCTCATGCCGGCAACAAGCTGGCCATGCAGGAGTTCATGATCCTCCCAGTCGGTGCAGCAAACTTCAGGGAAGCCATGCGCATTGGAGCGGAGGTTTACCACAACCTGAAGAATGTCATCAAGGAGAAATACGGGAAAGATGCCACCAATGTGGGGATGAAGGCGGGTTTGCTCCCAATATCCTGGAGAATAAAGAAGGCCTGGAGCTGCTGAAGACTGCCATTGGGAAAGCTGGCTACACTGATAAGGTGGTCATTGGCATGGACGTAGCAGCCTCCGAGTTCTTCAGGTCTGGGAAGTATGATCTGGACTTCAAGTCTCCGATGACCCCAGCAGGTACATCTCACCTGATCAGCTGGCTGACCTGTACAAGTCCTTCATCAAGGACTACCCAGTGGTGTCTATCGAAGATCCCTTTGACCAGGATGACTGGGGAGCTTGGCAGAAGTTCACGGCCAGTGCAGGAATCCAGGTAGTCGGGATGATCTCACAGTGACCAACCCAAAAAGGATTGCCAAGGCCGTGAACGAGAAGTCCTGCAACTGCCTCCTGCTCAAAGTCAACCAGATTGGCTCCGTGACCGAGTCGCTTCAGGCGTGCAAGTTGGCCCAGGCCAATGGTTGGGGCGTCATGGTGTCTCATCGTTCTGGGGAGACTGAAGATACCTTCATTGCTGACCTGGTTGTGGGGCTGTGCACTGGGCAGATCAAGACTGGTGCCCCTTGCCGATCTGAGCGCTTGGCCAAGTACAACCAGCTCCTCAGAATTGAAGAGGAGCTGGGCAGCAAGGCTAAGTTTGCCGGCAGGAACTTCAGAAACCCCCTGGCCAAGTAAGCTGTGGGCAGGCAAGCCCTTCGGTCACCTGTTGGCTAAATAGACCCCTCCCCTTGTGTCAGCTCGGGCAGCTTGAGGCCCCGACCAACGCTTGCAGGGGTCCCTGCTAGTTAGCGCCCCTCACCCGCCGCCGTGGAGTCCGTGCCGCTTCCTTAGAACTTCTACAGAACCGAGCTCCCCGGAGCCCTGTTTGGCAGCTCTAGCTTTCCCGTCGTGTAATTGGCCCAAATCACTGTTTTTCTCGCCTTACTTTCCACCAAGTGTCTGGAGTCATGTGAGCCTCGTGTCATCTCCGGGGTGGCCACAGCAAGATGCCTGGTGGTTTTGTGCTTAAAAATAAAAAGCCTCAGTGACCC + HHHFHIG'DBEE@G==EJ>H/DJ@B6=>AHFG@6HB;7;?@@G4+H4@CF;FCGAHBHHIA>?AG-GADHBGIH@H@?EDEFB7EBJGC@DIGG<;CF9HI4E>AF9>@A=CI*EAB9AH@FD7:BG3GGB@3B4D@JH.AAHGCFF8E6GGGGHH9=FI;AGEIEAFE$IF8>D@GBHII?GIGFBCB@$AHBEJ-ED;HFIIEEFIIIBFAGH4EBH/HIEFHHHIJDHHDBAGEGFE=HF@GJ,GEI:I>F9EDEBABBD7F99AG6GIGDJFHHHHFDEBCAF>GFC>GG=IHCEH?FE;IHEHI:C?8?-GD>DDF(?AIJDJ>HHHDGG?HF;IIFECHGGEDH@CD>AHIDD8G;FBD;AIDHC;9H$FAGFIEEI;>ADBH4DFI>HHFABFACGG>A<=<@G=?A?AHF>FFEEA9FHIAJFFG?DF@HE?EA>JGHIE@HA;>ADEBED@FAGDGHG>GIFIFIBFFBGE>GGFBGG0ECCF2G0HECF;@I@FBHJCEDGGEHF:GBC:@F?GJD4=CDEFC$FFFD8CGCHEEHEHFD@F?EI6D?G?F>BF6BHGDG6IEG?IGEG7HIGI=CBAEEEB@CF9AEIBDGBEHEEDG>FCG@DHCHI?GIHHIHEC;HFAFIHHGGC<=IGJFHI1GJ>G>DEGHBF1;AA8ACEGEAG@D?FFAHG@EEHBG>GJI=G?EB;HI@FGF9ABG4GHF?GCFHIED3ICEIEGG@GEGCE>FEE>F=JHIB?DFGFCG:EFFAHB5E>CG2C8>EGD;:0>FAB?/A8DBGEBEF7FD>D>@<@:9.ECCAGABFGC3BEE8CAED):@8GADEAACA<;DE>A86;EGG;>?AA0@=C?A7):CCECEC@AED=CEG9BDBD?;BGB?DAC.B7EAAEBDADGAFDCCD7?AFEEADD9=A@;:?@;B;?E>BDBEE0E9EEEF18BAB9G?:6EC;BAFEEGG@AEBB4CFCD?E;?9E;??(EE?DE>DC@DCDA*?FFFE?D;A=BB2GCBD?E@=DAB?>8=>GBDEEAAEFF;@DA'=E4EABCB$=C8EDEEGC?E=DE?CFE7CA:7?34=C=%2>CB@+?<7<>EBA?FGG1 @rCer/2180/2052_60_CCS ATGGGGCCGCCCGTGGAGCCCTGGGCCTGCTGACCCACCAGCTTAGGAGCACCCGCCAAGCTCTGGGTCAACGTGGAGGTGCCAGGCCACCATGCTCAGTCTCAAGCTGCCCCAACTTCTTCAAGTCCACCAGGTCCCCCGGGTGTTCTGGGAAGATGGCATCATGTCTGGCTACCGCCGCCCCACCAGCTCGGCTTTGGACTGTGTTTCTCAGCTCCTTCCAGATGACCAACGAGACGGTCAACATCTGGACTCACTTCGTGCCCACCTGGTACTTCCTGTGGCGGCTCCTGGCGCTGGCGGCGGCCCGGCTTCCGCGCGGGAGCCGTACCACTGGCCGCTGCTGTCTTCCTGCTGCCCGCCTGCCTCTACCCCTTCGCGTCGTGCTGCGCGCACACCTTCAGCTCCATGTCGCCCCGCGCGCGCCACATCTGCTACTTCCTGGACTACGGCGCGCTCAGCCTCTACAGCCTCGGCTGCGCCTTCCCCTATGCCGCCTACTCCATGCCGGCCTCCTGCTGCACGGCGCCTGCACCAGTTCTTTGTGCCTGCCGCCGCACTCAACTCCTTCTTGTGCACCGCGCCTCTCCTGCTACTCCCGTTTCCTGGAGCTGGAAAGCCCTGGGCTCAGTAAGGTTCTCCGCACAGCAGCCTTCGCCTATCCCTTCCTGTTCGACAACCTCCCACTCTTTTATCGGCTCGGCTGTGCTGGGGCAGGGGCCACAGCTGTGGGCAGGAGGTCCTGAGCACCAGCCATGGCTACCACCTCTTCTGTGCGCTGCTCACTGGCTTCTCTTCGCCTCCCACCTGCCTGAAAGGCTGGCACCAGGACGCTTTGACTACATCGGTGAGGGCACGCCTGGCCCGGCCCGGGAAGAGGCAGGGGCAGATGGCTTCCTAGAGCACAGAATGAACTGGGCCACAGCCACCAGCTATTCCACATCTGTGCAGTGCTGGGCACCCACTTCCAGCTGGAGGCAGTGCTGGCTGATATGGGATCGCGCAGAGCCTGGCTGGCCACACAGGAACCTGCCCTGGCCTGGCAGGCACAGTGGCCACACTGGTCTTGGCTGTAGCGGGAACCTACTCATCATTGCTGCTTTCACGGCCTCCCTGCTTCGGGCCCCCGGTACATGCCCTCTGCTGCAGGTGGCCCACTGGAGGGGGGTACTCAGGCAAACAACAGTGAAGCCCATCCCTGACCCTGCCCTGGAGGGGGCAGAGGCCAGGCCCCCGTGCTGAGGAGGAGCCAGAGTTGGGCCTAATCAGGTGGGGACACATCTCAGCTTGGAACCAACAGGGGCTGAGGAGAGAGGGCACAGGAGAGGGCACAGGAGAGGGCACAGGAGAGGAGGGGTGTCTAGGGGAAATGGCAGAGTGTGAGCGGGACTGTGAGGGGCTCTGATGGAGTAGAGGAAGTGCTGAGGGTCTTGAGAGGGGAGATGCATGCGTGTCCAGGCTGAAGATGCCCCCACACTCTGTCAAGGCTGGGCCAGGAGGTGTTGGGTCCTTTCATCTGGCTCCATTTCTGGTGCTCCTGAAGTCTCTGCTCAGCACAGGGAAGAACTAACACGACTAACCTAGGCCTACCCAAATGCTTCTTGCTAACCAGGCCGAGAGGCCACACACTTGCCCCCCATTCCCACAAACCAGGTAATGCAGTTTGCCAGCAGCTATTTGCCTAGAGAGATGAGTCTGTCCTGGTCATAACTGTGTACTCAAGGTGTCCAGGCTTTTGGGGTGGGCCTATCTGGGTGCATTGTGGATGGTTCAGTGGATTGAGGTGTGGGGGAGGAGGGTCCTAGGCTAGAGGGGGGATCCCTAGTTAAGACTTTAGGAAGCCACCTTCAATGTTTTCTGGAACAAGGCAGGTACAAATAAAAAAATAAAACTTTGGAAAGCACTTTCTAGAACTGAAGAAGGTAAAACCTCCTCACCCCCATCCTCCTGACACCTCCCTCCCACACTCCATAAACTGGACAGATTCACAAG + 25014*1.*33(-$+(1&,/.-04$0253413011.52530,2532-/0-144.2/&//4453,0(,323,)-*/+.431+.-0.$.,/2/2231.0/2/10540432531-&0325213*43)5,-+13,4/(44441.550,22/.5263612/050,/2/0(*%-+2044.244412./3($-//10233145,00,(%34330*%-241*12214.,(*')545--6-350-+0./)250,54155*1./1*10*001.-4/./024/0*%/-53.1,1/120023221/5511/*/3+/1+04,1/1552,054530'32-/*12/254+656530+//-&335-/02550100+0/)032.30-3506-301310.144'(,/314634+54-311.42260003/1-,*3%1-,3/112/)*%04352,511*+432*32.-15-541-506022.113204362&,0)0(,21306-33+,%)0.31,.)+.+',/54-3-424//-//$*03/353*$-1032544.,./,11.(0/0/%./--&-,0+.,..1,+,+&-,0/)-+.0/300$)...-/&%00/*(1164.-36*0-56425111*14*56615660)0)-1)223351+-636530/344.535*266342556+433,1/5,14642+64355144.4,34*1352.4310$.10003.322*0/3--.0/,01)'33421+1+%(*40.1*13.0402('352/020+/.4+04.-/-)553622140./.0..41,33-(201.1152335)26/12-1,013+2121020-6035-01.424+.532/304/.+/.0,5+31,.*)0613545/32-36++/0(+$-.642-3,1,(1*2206342121.23453,4453454*+5+62115+*30635-56/2,1-05262).025/20421)3132-41625332124./2*5331536632.5054123)/4244//13543/25/.53040524654/4.234554,.0$+,66461.-/,//2/2-1121.03*(,343,,00433,$'-&2*../0.,00(-1,.,2.)(+.(,/,.-.),15-40330514)*(13'3/33)-/1/202223546223%2513/(4.1,035444/+,/.0034*#.1+/302/1-040.30$)-/4.2026301213/11021331'32/1643.40/4424.31/2/-+00021./0(,10-0')/&5156/,/1402/./%3/.100*.-344*-*$1)2.00+,/00&)0)44)-+03104031/0**)+-).$.-314,240233324461//-3-3/--$,..(32054,0.(351/01,11)+'311/1*(-0.000430%+/)%/1-0%+023024.2//*0.+-)15(-.3(3/25,2/)**342,$0*./(+)11-3//056424522(-30/-)0++.3314,10534*#*)),+*,()*2*/0$.000,,1..)0,%'*0+&01(0/.%+,-)+0///..//+0.*-,.-.+/1-/-(1(-0'+./-+-+*,//0&)%(,2/,&+),.$,.+/01/)'/*+.&+*,++()+%-*++/)/,+-,+)+0-110/./'-+$/-%('',&-/))%&+),+&00.0&/0//41/3-,*/-,-400-213-0)10-'+2)315.34+12.'/12++130/'/34+.--/10)45/1545.334..32%-,2-&.0./'.//.0.04/*/14-6)1/00-+)-3.,,).)'*-(,%,/+/.(+*,./31'20/,./3210',/.,)&036-4/++,36,2122'26124102-0+*0360,*,/./-..+3-0.0,*0020.-304403*.113$/35*,+*-%/5421/(%)(20+30+-/.+(2-/,(.)63244,/.3544(1*+14/42/1-0.*-21.13/11014.4-222.-/-2-/.-,-+',-.(#- @rCer/2181/25_1547_CCS ATGGGAGAGGGTGCGTGGTCCGAGCCGACCTTCACGTCCACTGAAGCAGCCATCCAGTCCATGCTGGAGTGCCTGAAGAACAACGAACTCGGCAAAGCTTTGCGGCAGATCAGGGAGTGCAGAAGTCTGTGGCCCAATGACATCTTTGGAAGCAGTTCTGATGATGAGGTCCAGACACTACTGAATATTTATTTCCGTCACCAAACTCTGGGACAGACGGGTACTTATGCCCTGGTGGGGTCTAACCAGAGCCTGACCGAGATCTGCACCAAGCTGATGGAGCTGAACATGGAGATCCGGGACATGATCCGCAGGGCCCAGAGTTACCGAGTCCTCACTACTTTTCTTCCAGACTCCAGTGTTTCTGGCACTAGTCTCTGACAGGAGCCTCCTGTCCCCGCTGGGTTCCAAACTGGCAGTGCTGCCATGCTGGGGCGACGTCATTCGGTGTCTTCTCGGCCTTCAAAAGGCTTGGACAGACTGTTCTCCCTCTTGTTACCTGTAGGGCTTTTTCTAAAGAGGATGACAGAACTTCCAATGTGTAGCAATACTATAAGAACCAAGGTAGCTTAGAACGTCCTGGACAGACTCCACCCGTCACGCTGTGTGGCACAAATGTGTGACGTTTGACCGAGCATATGCAACTCACTACTGAAGAGGTGACTTCCGTTGCATACCAAAGCCGACTACACTGAACAGTACCTTCCTTTCTAGAAACGATTTTAGATTGGCAAAAGTGCAATGTTTTCTTCACTCACAAAATTTTATATTCTCAAACATGTACATTCTTTCCCTTTCTTGTTCCGTTTTCTTTTCTTTTTTCTTTTTCCTTTCTTTGGTGGGCTGAGAAAGGGGCAGGCAACATGAAGCTGGCCACTGAAAACTGTAAGACGGTCAAACGCTGACAGCCTGTGTATGTGAAAAGGGAATTGTAAACGGACTGCAATGTAATGTACACTGTAATTTGAATACAATTACTGTATCTAAAAGGAGCTGCTATGAACTACCTTTCTTATGTTGTTAGGCTACTGTTTCTGAAAGCCCTGGATCTCTTTGCACCAAAAATGGTCCAGATAGACTCTTTTTAAGGATCTTGGCTGCTTTTTACTAGAAGGTTGCTTTTATGAGCATATTTATACTGCTGAAGGATGAGTGTTAATTTTAATTAACTTTGCCATTTTGTAGAGAAAACTATTCACAATATAAATTCCACGTCTTTTCACCTATCAGGCATGCATATTTTAATATCTGTTTGGATAGCCAGAAGTAGAATCATAAAGGTAAAATATGAGTTGTTTCTTTGTTTCTTAAATGTCATATATTATGTGTAATATATATGTAAAGGGCCATTCTTAAGTTCTCTCCTTAAACTTAATGCTGTCAAGTGTTAGATGTGTGCATGTGAACTTGTTGCACAGCAGAAACATATTCAGAGTTTATCTATGTAACTTATTCACTCTGTAAATACATTTAAAGTTTTTGTGATGTAAGCTTAATTGATATTCTGTTCAGAACTTTCTTT + KKEKKKKKKKKKKKKKKKJJKKKKKKKKKKKKKK@KKKKKKKJKKKKKKGKKHJKJ7KKKKIKKKKKKIIKKKKKK>KKKKKKKKKKKIKJKKKKKKIKKKKKKKKKKKKKKKKHHGKCKKKKKKKKKKKKKEKKKFKKKKKKGKKDKKKKKIKKKGKKKKGKKKKJKKKKKKKKJKKKKKIKKKKKKKJKKKKKIKKKIKKKKKKKJKKEKKKKJKKKKKKKKKJKIK@KKKKKKKKKKKJGKGKKKKKK5KKKKKKKKKKKKKK>KKKKKKKKKKJKIKJKKKKKKKKKJKKKKKKKKKKKGKKKKKKKKJKKKKKKKKKKJKKKKJJFIIJKKKBKKJKKKKKKKKKKEKKBKKKJKKKJKKKKKKJKKKKKKKKEKKKKKE:KKGKKK6KKKKKKKJKKKDKKKFKIKKKKJKK=KKKKKKKKKBKKKKKJKKK @rCer/2182/25_1801_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCGTGCTGCTGACCGAGGCCCCCTGACCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTGGCTTGACTCAGGATTTAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTCAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAATTTTTTTAATCTTCGCCTTATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCTT + )8=FCE@AA;=DCBA>/DDCDA5?@/BB>ABC?@A8=(EAB&==5?/>.@EB:B@C>*<>7A@=EC::804<-&@>2*:BDJ?=-@A@?@D<@?=,3C=C>3FCEHEIEFGCBBG8IJHAE@D7:7795@AJ?KFE9HEDB4GA83:22;8>A5?88@>95>2FG;8;>>2-62GHDA2?EAB<9<00?GG3H25:3.GAAD?C79>1@AE;5?-=<>CD,CC>DCC)CA;=,?05(C==6@A@7;DD@+FFE<<:2AFF?D79@?D=G?IDE<7=0B0)09+?@AA>8=B556?9E=8.>/?AE><:#%A@4BDH9D1B99B)HD-C=,9:>=0CC3<9>/DCHE.E62-@FD;;:HA4?2@F4;4;;E=@>HA6?D:A?CE-5?4HD9@>D:>AA>=.&7<45=@=4599>@=CD>CE43:I;C<;F5A6?HE1C9;>E>1HD=?C@7:00FGA/HB:9&17/C:C4@::9;425,<;?A<9A:A3?HD;FA;&9,46H0D5D40DB?4E@DA?6=:3<:BF52@;9?03E:G>B?C?&:='=1D87>;=F=2HFA6D4:2D?@=@39B9=<0;>+FDB<-8FCDC;=A9378<=E4&AAJHGJI:C6D>C5C/G9?3@4A>2<>?H@<;?71B-B5?@H3G<@3C>B9-=F<4;8?;B?5A@A:4=9C9-5@839=>/99:>?==23:@AFD>A1CA7:@@DC:8?A>8:C9=:96<+7+=09838:=;/),:2.4+:7;2'5=6:5.6341=B6:<;8;?5:/9@G??C?;3=#)<:83DCF=/+:@9?6519DF/=AAA>.==9B<8>85DA:BHABF6B?DC=>AC@@=FF;4CBA>;*;14;299H39B6D>9B?F>E%55H4?E9F@;><5<91?46@4;6:;,??825;;7D48,.:<8>=6;64/075.882>==@0955,@=1<07296:9:>=7<>D55?<9485;;B><9@=:?9;11)3;4%:9''6>5A0CC@*>287:+?:;3536)==8&965E76;7:E3D&%$85:@@C@33?@6>9=8637=26=>A;1@7;81<65*96=?>=04+56=.@BB;0>894@89&;73:;4@*:8688@@;9=;64;B:1;?6792>3,=;:;AA7;126/:=;75@.<:9:;5?4=8<=71<>/?=?@579C;9&;43=7,A<:;75$7:/1:9.>@B79:>,67:730B@A9@>?509/3?<=652;=9*>5;5:=?9687-.9-933<=05'7;':,*2;<=B<>1:69$,78+:>>:63.86664<;99'9950.665A<<:3<1>:;635'::;9;/)::62A>551/@=?A>5>B59,1;,?=:66;=95<;0'9>>6>16:6;6;/::.:5>6688777?;;<12/207.9 @rCer/2184/1851_59_CCS ATGGGGAGTCTCGCGCCCGCTGAGCGGCGGTTCGGAAGTGGGGAGCGCGCCGGCCCGAGCTCGCTCGGCCACGCGCCCCGCCCCTCAGAGGCCGGCCTCCTGCTCTCTCCGCACGGCCTGCTGCGCCCGCGAGTCCCGAGCGCTCGGTCGCCCGCCCCGACCGGGGCCCAGCCGCCTCCACGGCCCGCGCTCGTACTGGAGCGAAGAGCGGCCTCTGGAAGGAGGGGAAGGGACGTGGGGGCGGCCACGGCAGGATTAACCTCCATTTCAGCTAATCATGGAGAGATTAAAGTCTCTCCTGATTATAATTGGTTTAGAGGTACAGTTCCCCTTAAAAAGATTATCGTAGATGATGATGACAGTAAGATATGGTCGCTCTATGATGCAGGCCCCCGAAGTATCAGGTGTCCTCTCATATTCCTGCCCCCCGTCAGTGGAACTGCAGATGTCTTTTTCCGGCAGATTTTGGCTCTGACTGGATGGGGTTACCGGGTTATCGCTTTGCAGTATCCAGTTTATTGGGACCATCTTGAGTTCTGTGATGGATTCAGAAACTTTTAGACCATTTACAATTGGATAAAGTTCATCTTTTTGGCGCTTCTTTGGGAGGCTTTTTGGCCCAGAAATTTGCTGAATATACTCACAAATCTCCTAGAGTCCATTCCCTAATCCTCTGCAATTCCTTCAGTGACACCTCTATCTTCAACCAAACTTGGACTGCAAACAGCTTTTGGCTGATGCCCGCATTTATGCTCAAAAAAATAGTTCTTGGAAATTTTTCATCTGGCCCGGTGGACCCTATGATGGCTGATGCCATTGATTTCATGGTAGACAGGCTAGAAAGTTTGGGTCAGAGTGAACTGGCTTCAAGACTTACCTTGAATTGTCAAAATTCCTATGTGGAACCTCATAAAATTCGGGACATCCCTGTAACCATTATGGATGTGTTTGATCAGAGTGCACTTTCAACTGAAGCTAAAGAAGAAATGTACAAGCTGTATCCTAATGCCCGAAGAGCTCACCTGAAAACAGGAGGCAATTTCCCATACCTGTGCAGAAGTGCAGAGGTGAATCTTTATGTACAGATACATTTGCTACAATTCCATGGAACCAAATACGCAGCCATTGACCCATCAATGGTCAGTGCCGAGGAGCTTGAGGTACAGAAAGGCAGCCTTGGCATCAACCAGGAGGAGCAGTAGTGTGTGTCTCGCTGTCAATGATGAGTTGACCCGGTGTGTTCTCGTATAGTCAGTGGCATCAGCGCCCGCCAGCCGGCCTTTTCCTTCAGGTTTGTCAGGCTCACCGATTCTCACTGTGTCTGGGAAGTAGGACTGATGGTCATCTTCGTGACAGGCAGCAGCTCCACTAAGCCTGAGCAAGTGTTCCCTCTTGGTTTTCTTAGCTTTGAATTTGAAGAAGTACTTTCGAAGATTCCCATTTTAAGAACCATGCAAATTTTGCTACCAAAAGTCTTCACCACTGTGTTCTTAAATGAATGTTAACTTCTGAGGTTTGGAACTTTGTGGTGTTTTTTCCTTCTTTTCTTTTCCATTCTTCTTTCTTTCTTTTTATGTTGTTTGCTGTAAATGCTGCACATCCAGATTGCATATTGGGACATTGGTTATTTTATGCTTTCTTGGATATAACCATGATCAGAGTGCCATGGCCACTACCCCACTGTTTGCTCTCCTGCAAATCAACTGCTTTTAATTTACACTTAAGCAAATTGTTTTGAGTGTTAGCTACTGCCTTTCTAGCTATTACAGTCATTTGGAATAAAATTCAGTTT + KKKKK8KJKKIIKKKKK;KKKKKKKKKKKKKKKKKKKIKKKKGKKKKKKKKKKKK4KKKKKKKKKKKEKFKKKKKKKKHKKKKKKKKJKKKEKKKKKKKJKGJKKKKBKKKKGKKKKKKK(KKJKKKKKK;KK9KKKFKK=KKKKKKKKKKKKKKKKKKBKKKKKKKKKKKKJKKKKJKKKKK=KBKJKKKKKAKKKKKKK7KIKKKKKKKKIKKKKKKKKKKKKKKKKKK=JKKKCKKGKEKK3KKKK.JKJKKKGKKAKJKKGKKKGKKKKKKKKIGKKHKKIKKKKKKK9KKKKKHKKIKKKJ@JGKKK8KKK7KKHKKKKKKJKKJKKKIKKBKKHKKJK>KKKKKKKKKGKJKKKK>KKKKKKKKKK:K5KKKKJKKKK@K6KKKGKKJKKKBKKKKKKKKKKKKKKJKKJKKKAKJKKKKJKJKKJKKK@KKIKKKKKKJIKK;KKIKKKHKKKKKKKKKKKEJKKFEKJKKKKKKJKKKKHKKKJDKIKHDJKJKIKKKKKKKIKKIHKKKKKKKKKGKKJKDKKKHKKHJHKJGEKKKKKKIK7KKKKKKKKKK6KKKKKKKK2KJKKKAKJKHKKKKKKAKKKKKIJKKKKBKJK2KKKKG>JJJJKJKK0KDJKKKKKKFKH5KKKKDJKKGJKKKKJKKCKHEKJKKKKKKKKKJKKCJKKJKK=@JCKAKK5KJKAK7KKK'KKIICGKK$JKGKK5KKKKKHKKKKKKKKKK7JGKKKKDKKKK.KKKK;KKKKKKKK1KKK0KKKJKKKKKFKKKKIKKKJIIKJGKKDKKBKKBKKKAKKKJKKGKIKKKKKKKK@K>KAKKKKGK'JJKIJKK8 @rCer/2185/2119_53_CCS ATGGGGATTGCAGCGTCGGATGTGCAGAGCAGCAGCCGCCGGCGTCCTCGGATGTTGTGTTACCCGCCATCATGAGCTACACAGGCTTTGTCCAGGGATCTGAAACCACTTTGCAGTCGACATACTCGGATACCAGTGCTCAGCCCACCTGTGATTATGGATATGGAACTTGGAACTCTGGGACAAATAGAGGCTACGAGGGCTATGGCTATGGCTATGGCTATGGCCAGGATAACACCACCAACTATGGGTATGGTATGGCCACTTCACACTCTTGGGAAATGCCTAGCTCTGACACAAATGCAAACACTAGTGCCTCGGGTAGCGCCAGTGCCGATTCCGTTTTATCCAGAATTAACCAGCGCTTAGATATGGTGCCGCATTTGGAGACAGACATGATGCAAGGAGGCGTGTACGGCTCAGGTGGAGAAAGGTATGACTCCTATGAGTCCTGTGACTCAAGGGCCGTCCTGAGTGAGCGCGACCTGTACCGGTCAGGCTATGACTACAGCGAGCTTGACCCTGAGATGGAAATGGCCTATGAGGGCCAATACGATGCCTACCGCGACCAGTTCCGCATGCGTGGCAACGACACCTTCGGTCCCAGGGCGCAGGGCTGGGCCCGGGATGCCCGAAGCGGCCGGCCGATGGCCTCAGGCTATGGGCGCATGTGGGAAGACCCCATGGGGGCCCGGGGCCAGTGCATGTCTGGTGCCTCTCGGCTGCCCTCCCTCTTCTCCCAGAACATCATCCCCGAGTATGGCATGTTCCAGGGCATGCGAGGCGGGGGCGCCTTCCCAGGCGGCTCCCGCTTTGGCTTCGGGTTTGGCAATGGCATGAAGCAGATGAGGCGGACCTGGAAGACTTGGACCACAGCCGACTTCCGGACCAAGAAGAAGAAGAGAAAACAGGGCGGCAGTCCTGATGAGCCGGATAGCAAAGCCACCCGCACAGACTGCTCGGACAACAGTGACTCAGACAATGATGAGGGCACCGAGGGGGAAGCCACAGAGGGCCTTGAAGGCACCGAGGCTGTAGAGAAGGGCTCCAGAGTGGACGGAGAGGACGAGGAGGGAAAAGAGGATGGGAGAGAAGAAGGCAAAGAGGATTCAGAGAAGGGGGCCCTGACCACTCAGGATGAGAATGGCCAGACCAAGCGCAAGTTACAGGCAGGCAAGAAGAGTCAGGACAAGCAGAAAAAGCGGCAGCGAGACCGCATGGTGGAAAGGATCCAGTTTGTGTGTTCTCTCTGCAAATACCGGACCTTCTATGAGGATGAGATGGCCAGCCATCTTGACAGCAAGTTCCACAAGGAACACTTCAAGTACGTAGGCACCAAGCTCCCTAAGCAGACGGCTGACTTTCTGCAGGAGTACGTCACCAACAAGACCAAGAAGACAGAGGAGCTCCGAAAAACTGTAGAGGACCTTGATGGCCTCATCCAGCAAATCTACAGAGACCAGGATCTGACCCAGGAAATTGCCATGGAGCATTTTGTGAAGAAGGTAGAGGCAGCCCATTGTGCAGCCTGCGACCTCTTCATTCCCATGCAGTTTGGGATCATCCAGAAGCACCTGAAGACCATGGATCACAACCGGAACCGCAGGCTCATGATGGAGCAGTCCAAGAAGTCCTCGCTCATGGTGGCCCGCAGTATTCTCAACAACAAGCTCATCAGCAAGAAGCTGGAGCGCTACCTGAAGGGCGAGAACCCTTTCACCGACAGCCCCGAGGAGGAGGCTGAGGGCGGTGCCCTGGACGAGGGGGCACAGGGCGAAGCGGCAGGGGTCTCGGAGGGTGCAGAGGGCGCGCCGGCGCAGCCTCCCGTGCCCCCAGAGCCAGCCCCCGGCGCCGTGTCGCCGCCACCGCCGCCGCCCCCAGAGGAGGAGGAGGAGGGCGCCGTGCCCTTGCTGGGAGGGGCGCTGCAACGCCAGATCCGCGGCATCCCGGGCCTCGACGTTGAGGACGACGAGGAGGGCGGCGGGGGCGTCCCGTGACCCGAGCTCGGGGTGGGCGGGGCCCGCGTGGCCGAAGCTGGAAGCCAAACCTAATAAAGTTTTCCCATC + EKKKKCJKJKKKJKKKJKGKKKKKKKKKKEGIKKKKKKKHKKKKEKEKKKDK=KKHKKKKHJKKJKKAKHIKKKKKKJJGKKKKKHKKKKKKKKKKJKKKKKKK0KKGKKK+IKKKKKKKKKKKDJJKIKKKKIKKKIKKKKKKK;KKKKKJKJKKKKKHKKK?KKKJKKKKKKKKKKKKKCKKKKIGKKHKKKFGKKJKKHCIIKKKKHKKKKK=AKKKKEKKKKKKKKFKKKHKKKIDKJKDKKKKKJGHKGKKKKGKJKKFKKHKHKKKHIKHKKCKKBKKKHKIKKKKKKKKKKKKHKKKKKFKKKKKKKKKJJKKKKKKKKKKJIKKKKKKKKKKKKKKKAKKKKKFKFJGKIKCAKKKKKGJJKBK?KEKKJ:JKBKKHKFKJKKKKKKJGKKKKIKKKKKKKKJKJDEJKJJKKIKJKKCKKKKKIKKK?KKHJJKHK>KKKIKFEKJKJ?JKKHKKJKKKJKKIJ>KJKKHKJKEKKK?KKKKKKKKKDKKJKKIKKKCJKIKJIKKKKKKKKAHJKKKIKKKJKKKIJKHK8KKKEKJHKJKKKK8KKJFIHKKKJIKKEKIKJKJKKEBAKKKHIKKKK5KKKIKJJKDFK;KKIKKKKHKKKKFKKKKHKKKHKK3KKBKIEKJI=KKK?KKJFHJKKJJKKJIKJKKKKKJIKKKKKKJDIKKHKJKKJIKKJKJKKFK=KKCKKIKK=KKHJJI+JHKKAKKHJGJKKJIHKKKKJKKKKJFKIKKK3GKHKKKKKKKKKJKKKKGJHK5KKKKKKKKKIKKJKIJDKFJKKKKJKKKKIKKKKKKKK'KFKKJHKJKKKKJKIKIKKJKKKJKJKKKJJKKKHJKKKHKKKKJKKKIKKKKGGKKJHKGKKIKKKKJKKJ/KKE/EKJDJJJJ4JKKKIFKKKKKIKK5KKK>JJ?KKKKKKKKKKK6KK=KKKKKJKKKKKJKKKHKKKKKKKHIKJKKKHKKKKKKKKCKJKJKJKIKIKKJKKKKBKKEKJGKKKJKKKKKHKJKKDIKJKJKKKKKKHKKK9KHKKKKKJJKKKIKKGKKKKAFHKKK5KHIKKKIKKKGKKKKGKIK4KKKKKKKJ:JJJKKKKKKKKKJGCK@KKKKK?KKKJKKKKJKKFJ1KIEKKKFKKIGKJKJKKK@KKKKGKKKJKKHKKIKKKKKJKKJKKJKK>K@HKJGKKKCKKKKKK=KKKK?JKKKFKKKKKKKKKKKKKKIKIJKKJKIKKKKKKJKKKAKFJ*KKJKEKJKJKKIKIIKIBKJKKBJKFKCKIKKKIKFKJKKKKKKKKKKJDJKKKJBKKKKK8KKJKK=KKKKKKGKKJIKJKKJFKKKJIKKKFKKDKKKJKGKIKKIJKKKIKFKKGKKHKIJKIKKK0KKKKHJCIKJ@?IKKKKCJKDKKK=KKKJKJ4HKKJKH@KKKFKKIKJJKK3KIJJKKHKAKKKKKKKI1HKKEKKKKKKEKKKKCKKKKKKKKKKKJKJGKKK?KKKGDKGJKJKKJ:KKKIIKIJGIKKKKKJKIIKIKJ1KKJKFKEDJKKKKKKJJKKJJKKKIEKEIKJKKKKKKKKJIBJBKK9GIKKKKJGKKKKKJKKJ?FIKKJ>IKJKKKKKKKHI:KKKE>K@KKKKKKJKKJKKIJKKKKKKIGKKKKJKK>KFKKIDKKKKKKKKKKKIKKKKKKKKKKCJKKJKKKCKKJFKKAKFKKJIKKKKHKKIKJK=GK9KJKKIKKKKKJKKKKKIKKKKKJJ>KKKKIKKJKKKKK8KKIKKJKKKK7>:HJHIKKKKKBKKKKKJKKKKKKBKKKJKK>KKKJKKKKKKKKKKKCKKJKKK?KKKIKKKKDHKKKKGJKJKJKKKKKKKKKKIKKK:KKKKKKKKKD,KKKAD@DKFJKKKJKKKKKKKDKKKKKKDGKKKKFKKKKKKK/KKKD @rCer/2187/911_58_CCS GCTGAAGACGTGGTGGTGAGGAAGTAAGCAGGCCCCCAGGAAGGCGAGAGTGAAGGCTTCTGCTGTGCTTTTGACGGTTCCACAGCAAAGATGTGATCCTTGCGCGAGGAGTCTGGCAAACCCAGCTCCTTGCAAGATCTTGGAGAGCTGCACACAACACCGGAGCGAGTTTATGTAGTGTATGGCCTCACCTTCAGGCAAGGGAAGGACGTAATTGAAAGCATAGATAATGGCACAAAAGATTTATCAGAACTACTATAAGTGTGAAATACTGTTCTGATAGTGACTAACGAAAAACAATTTACCATTATCTATACCATAGTTGGTAATCTAGTTCCAATGCAGTGTGACATGCTTTATGAAATAATAGTGTCTTTCTACGGCATGTAATGCAGTGAACCTAAATACCGATGATGCGTTTACCTATTTGCAACTAAACATCACAGCATAACACTTCAAAAACCATACAAATTTTCAGCAACCAGTGGCAGCATATTTTGAAAGTGGGAATAGTGGAGAAAGTTGTTTTTGCTTATGAAAACCTACAGTCCCAATCTCTACATCCTTTCGATTGCTCACAAGGCAGTAATTCACTCTGACTACTGCTTAGGCTAAGACATAGCAGCTGCACAGAAGGTTACATCTGTTTTCCCTACAATGTTGCTTACAAGCCACTCATCCTCAATTACCTAGACCTAGCTTGATCATGCGGTAAGAAATGCCGGTTGGAGTTGGGGTCTGGGGATCCTCATTAGGGAATTACTTTTTATCAATATGTGTTTCAAGCACTGTTCTGTACAAGAGGAGATGCTTGTAGATATAGTATGTAGAGCCAGCGGTTTCACATAATATT + -.,*/--.),'-)-.**,.,'.'.+.-,./.#$,&&'$#*-)%%-,))-')+.,.%-,*/)/.,**'.%(*#.../'*(.--//..,'.*)./,.,*(.*$-./....)/,-//&.*,+.-(,///.-/((..&./--/,'/).-.--/%-*-&,--*/../(.-'..$/#)--,(-,(..,./)(,'-*,)-*//.(/-..'&*,-$*-,(').(.)*(+//-.-/++-'-(,$''&%)-"'%)#*&%.,&--.+./+/'-/.,-/(-+(.--(#.*-.'-+,*-,$.&...)++,-...*+/.#.,)/+,*/./--,$-(+',)*/-&*+)..'*+-.,*),.,**&,-,*)-*'*.,..$.+/.,/-$+-/.&&/-/..*./,+,.-..///,).&.-,)*,,.-,,+,-..,+(("*.)%.(,'*-..&,*)'-./.+..-/+/,-+.,),(--%#+..-///)-$**&#).,-.-)+..,*,&..+//-+)#+),.#$$-+,(/.-.*,/+.-/#,*+#.+'++,...*../-),'.'+*./,+,-+.-//.-.///-..,)*-)/%'.-,.//..+'//+-,.#,...((*#+*+--'.-*(.-$(-/)./-.)(%..)./--/)(./)/+-%%//./..+#&)%+'#..)-+-'(/,/$/*-./*&''&)$(&'--*..$*.(.*$,..../-.*(./.-%/)'+*++.,$(..*#.*.'.)-**&-*'".--)%()..,'-%$(#&*%%*+$&/.,**++/-.-+$,*,**$(#.*+..///.,'#/.-+.-),)&'-,/,++.'/-/-/-/-..,.'/+//.')'.'*-),)-/-//-,)+.+& @rCer/2191/1975_60_CCS ATGGGGGCAGGGCTCCCAAAATGGCGAGTGAGGCTGCGGGACTCGCTGAGCAGCGGAGGGGAGCGTGCAGAGCGCTTCGGCCCTCACAGTCCGGAGCCCGGCTGGGCCGTGCCGTAGGGAACATGCACTTTTCCATTCCCGAAACCGAGTCCCGCAGCGGGGACAGCGGCGGCTCCGCTTACGTGGCCTATAACATTCACGTGAATGGAGTCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGCCAATGTACTTCCTGCATTCCCCCAAAGAAGCTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACCCATTGCTTGGGAGCAGCGAGACCTTCAACAGTTTCCTGCGTCGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGGAAGTGCTGCTCAGCAACGGGCAGAAAGTTCTTATCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCCGCAAAGCTGGATCTTCCAGATGACTTGATTGGATACTTTAGCCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGCAAGAGTTGAGCTGCCTTATGTGTCTGTTACTAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTGAGGAAGAGTTATTGGGACTCTGCCTATGATGACGATGTCATGGAGAACCGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCACCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAGGTCTCCAGAAGGAGTTCCTGAGACTGGCCCAGACACTGCGGCACTATGGCTACCTGCGCTTTGATGCCTGTGTGGCTGACTTCCCGGAAAAGGACTGTCCGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGCAGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGTCACCTCCTCTGTGCCATTGCCCAGTGGAAGCACGAGCAGCCCGGGCCGGGGCCGGGGCGAGGTGCGCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTACAGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTGGATGAACTGATGGTGAAGAAATCAGGCGGCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGCACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTGAGTCACCTGATGCCACCCGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCTGTGAGCTTGCGGGGAATTGGCAGTCCAGCACAGATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCTTTACCCGTGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCAAGCTGGGAGGGAGGGTCTTTTCCTTCTCCTTCCTACCTTCCCCTTTTCTCTGGCCAGGGCCTTGTAATGTACCTTTCCTCGTCCCTGGGCTGGCTGCACAGAGGATTCCCCTTCTCTTTTCAGAGCTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGACCATGGCTACCTGCCTTGGGGAGGAACCACAACTCCCTCTGGGCCGCTTCTGGCTTCTTGGGCCATGGGCCAAAGGCCAAGGGGATGGGCAGAGGTCTGTGTTGGTCTGGCCTAGTTCCCATCATTAAACTCAGCCTGATTGCTGCC + G=JIEH.JKKKDB8:G,KKK;J=6IKIGHAE>5AJC;BJ&GHBHID?FIHIEE?KFFDDD.CIFF9IIJKE>&CHIHJIBKI3JJJIGKJKJI@H>KA=>'IJJJBIG:A9>5BIFKK/KIJKHGHJJHJF=E7IIFF?*EJFGK'IE@B=F??3GGBEJK7KK?HJGHIFKGKDCGDKCEJCDFFIIJEHIF6?HIHC@EDDIEDHKIGK7DHGFH?@?J&?BHC=EE?HJCHIH@GJ/KEG;IFJFBJ>&-,E@@BAJBK?KAKJJFKIGKJB%IIAJJ=IJKG&?KIKKGEHHJCCCIIHJIHDGHHC;HJIII2IAIFIGGEIHH?5JKJF>F92FJGHI;3GG+F?IA?GJE9F4GDJIF@F?B%HIHF'FI?BDE+KH6H;BED@>+CHGK3=K?BHGDKKKJIH9IJKKBIIKK8IJJK5JBGED?BFEJ'GJKKIJJ3K9JHFIHAF@JK8KIHB;HKK:JJCI>KKKDJEJKIFB?KB=>DKEI:AFG0IFKIJFICEE;IGGFDJIJHKJJGFJAIEG>=3C(J>F6C-JKKGE&IJHDI;.1@BEG>AFED,EJEJGH=CHA/DJDGAA<@?CKBJHHBDJIIKEG9JFFEKAEGGJBH@KDJKFGKKKJEHIKKJJID3FHGKCKGJ=?H/$/J94'C5HCJ6KKJKDI;I3GK%JIIIKE@FEH=ACJIJGI>DJJK8KIIJKKKCFKJFC$JGFKIK>AGGIBK>KE*GCJKKBC-HIFIJK,JJH?6F6IDKEFB39G6DJFJIDCJJEBKKKGGEJCJKKKGKAKFCBGIFGBHJKCK=J1JF'KJFIF(JGIKHG@CG%=KDI7HB4JIIGIHKABI=KIK8BHII)J:CKJIDGKKJIKK8KK2I;IIJ0HAKJK,KKKBBKKJ=%DKDKF;HKEJJGJ2AFAE+F8HGKIGE4HF3@>GKI:;IIKK/KH7CIEKJKJHKKJJ=CF=EHHGI-IJGKJKBIGA1=J=2:KKHGGFJIJ8JGI2>KK@IHG<4KG4FIIDIFEKKEK9IJGDG7IIG@6HGDA<.:AGFC%J@KJAKGA98IJEIHH@BHFHKJJHKKIKJGJIJC@E@EKF0=B<<7BCJHCADCEBDFDEIK7DD;@;7':'FDDC9KHBDEFKJ7IGJ8KK>BFKEEJJAHBG;IKKK@K;@KAEAFFI&J?F/<=.B?:E%CCB=IEEDJHF@FCH=A<9H=IJFHJI8IIF3F>DJK=JJKGKJIJJHK7JIK@A0E9HJGJG&C=HHKDKEC9HJ>JHKJIH:F2JJFGFDEGG%KKAEFJ+KHBBK=IK6HIKJKKDKKBIKG.@JGBD'E@IF9BKKK.K=BCCJ6&IIF0DFC&>8=JF9HB@@FCK$>BG-FGKHK?EJI'GK==JID&57JABIK(77K=HDGCHJK=J3JJ?G*HEJJKK:JKK?JEKKIBHAJJHFID=IKDHKI*H;C=AJIK/G>3C@KGKEKC)FJJJ@CKBKJ*ECCHDKKKGJDIJIKKDKJJJKJ=FJIAB=F,KKJKKKGHHJJEHJKEK6KKK5DJ@KIKEKIK?CAKK-JGJKJ-K0I?KBEJK;IKE)E>JJ4HIEFKDC@5FJ3HKKKJ6HG*FKKEKE1BKHKIJJEKKF @rCer/2192/1640_56_CCS ATGGTCCTCTGATGCAGGAATGCCACCAGTTATGCCAGGCATGCACCTGGAATGATGCCAATGGTGGAATGATGCCACTGGACAGAATACCACCTCTGATGCCTGGAATGCACCAGGTATGCCCCACCTGTTCCACGTCTGGAATTCTCCAATGACCAAGCACAGGCTGTTTCAGCGCAGGTATTCTTAATAGACCACCTGCACAACAGCAACTGTACTGCTCCGCAGCCTCCAGTTACTAAGCCTCTTTTCCCCAGTGCTGGCAGATGGGGACACCTGTCACAAGCTCAAGTACAGCTTCATCCAATTCAGAAAGTCTGTCTGCATCTTCTAAAGCTCTGTTTCCTAGCACAGCACAAGCTCAGCAGCTGTCCAAGACCTGTTGGTACAGATTTCAAACCTTAAATAGTACCCCTGCAACAACTACAGAACCCCAAAGCCTACATTCCTGCTTATACACAGTCTACAGCTTCAACACTAGTACAACAAATAGTACTGCAGCTAAACCAGCAGCTTCAATAACAAGTAAGCCTGCTACACTCACAACAACTAGTGCAACCAGTAAGTTGATCCATCCAGATGAGGATATATCCCTGGAAGAGAGAAGGGCACAGTTACCTAAATATCAACGTAATCTTCCTCGGCCAGGACAGGCCCCATCGTAATCCACAGTTGGACCAATTGGAGTATGATGCCACCACAGCCAGCATCCCACAGCAACAAGGAATGAGACCCCAATGCACTCATGGTCAGTATGGTGGTCATCATCAAGGCATGCCAGGATACCTTCCTGGTGCTATGCCCCGTATGGGCAGGGACCGCCAATGGTGCCCCTTACCAGGGTGGCCTCCTCGACCTCCGATGGAATGAGACCTCCTGTAATGTCGCAAGGTGGCCGTTACTGATCTTACTTCATCCAGTCTAATAGTTTGGAGATTAAACCTTTTCTCAACTTGTGCTGTTTATATAGCCAAGCTTCCGTCAATAAGGCTTCATTGTGACTTTAACAAACATTATCTTCCACATACCAGGAACTATTGGACATTTATTTTACATGGGAAAAATTATTTGGAATAATAAAGCAGGAACTTTTCCTGAAGTTGCAATTTATACTGTATGCTTCTTTTTCATGTTTCATCTAGGTTTTTAGAAGTGAAGTATAGTAAATTTGGTTCGTTAAATTGTGAAGGCGCTGGAATTACATGAACATACCACCTTAATAAAGGCAAGTTCTGTAAGCTTACATTGCTATTTGTAAAGTTTGCCTTCACAGCATTTCAGATGCTGTTGGACTTCATGTCCCAACCTAGCTTGGTGAGGCTGTAACTGTTTCCAAGTACTTGTACATTGGAAGTCTGAATGTGTAACAATATTTAATGTATTTAGAGTTCCTCATGTTGCAGGTTTAAGAAATCTGACCCACCAAGGTCATGTGACTTTTCTGTACTGTTAAACTTCATTGTAATAAAACGAGAGAAAAATTTATGCCTTTTATTCATAACCCAGCTGTGGACCACTGCCTGAAAGGTTTGTACAAATGCATGCACAGTAGATGTCACATAATAAAATTTATAGTTACCAATG + JAJ%@;AIEIJDK@'JK4KJKKK,KKHKJKHKIJH)KJ7CJKKDCKAKKHK1HKKKKK?KKIK'GJ?KJKFKKIJ0<$KK;H4C3I@KJI;>H6HJIJKJKK=?KJKKK<)?I1KK,IGJGKFJ.KK4JIKJK?KK?K'GK0K=KH(IG7K5KJKK3J@?@@KIK7KHKKKKKJKK@KKKKEKK@KIKKKKHKJ:FGKKK3KCKKKKKCIKKKKKKJKAKK8KKKKKKKK=KK0KK,KKK@G-KKDKKKKKDKKKJKCKKKKHKKHHKIFH,JKKK@JKKIKKKKKKKKKK&KKAKKGKKKKKKK(KKKK8KKKKKKKKKBAKKKKKKKKKI$KKKKKKKKKAIKKAKKKKKHKKKKKKKKK5K*KKKKJJK7KKJKKIHKHBKKKJK5KKKJJFKKKJKJKIBKJKKKKKJKKJK8KKKK9AKKKKKK+KKK7KKKKKKKKK(KKKH-K,KKAKKKFKJKKKIG=KKJKKKKJK,/,KK6KKKKK-KKHKKKK5KKKKK8KK%KK8KKKK?KKKHKKKKKIKK*K,KKKKKKKKK=KCKGKFKKKKKKKKKKKKKK*DKBK&KKEKKKKAK,KKK.JKJKKKKKKJJKKKKKKKKKKKKKJKJKKKKKKKKKKKKKKK%KKKKKKKJKHKKKKGKJJKK:KKKKKJKKJK,JJKKKKJKKFKI;KKKKK;JKKKKKKKKK7KKKKK@#KKKK/KJKKKKKGKJKKKIKKGKKKK4KKKKKK,K3KKKKKKIKKKJKKBKKKKKKJKI0JKKHKKKKCKKKKKKGKKKKKKKAKKKKK:KIKKKIKKIKKKKKKKK9KKKKK.KIKKKKKKHKGCKKIK/KKKKKKKDK7KKKEKKKKKKKKHDK>KKKKJIKKKKKKKKKKIKKK5JK3KKJKKKKKKKKHKKKKK>IKKKJK@KKKGKKKKCKK-KKK2KKKEKKKGKKKK/KKKKKKIIKKK:KJKI7KKKKDKKKKKKKK>KKKJKJKKJKKKKKKKKKJKKKKJKKKKKKKKKKKI=KJK+KKKKKKKKKKK)>KJKKJKKKKHHK(KKKKKK@KKKKKKKKHKKK3JJKKKHKKKKKK@GKJKKKKKKKHKKKK?HGI@KIKKKK4KKIKKKK+KKK&JKEKKKKJKK'KKKKGKKDKKCK?KKKJKKKKKKFKKIKKKKKK=KKKKKK*KKKKKKKKK>K&H3KKKKKKKK3KKJJKKKKKKKKKEKK @rCer/2193/2167_59_CCS GGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCAATTCTATGAAGAGGTACATGACTTGGAAAGAAAGTATGCAGCACTATACCAGCCTCTTTTTGACAAGAGAAGAGAATTTATCACCGGTGATGTTGAACCAACAGATGCGGAATCGGAATGGCACAGTGAAAAGAAGAGGAAGAAAATTGGCTGGAGACATGAAAAATAAAGTAGTCATAACAGAAAAAAGAGCAGCAACAGCTGAAGAGCCAAATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTAGAAATGTAGATATGCTAAGTGAATTAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAGTTTTCTGACCCTGGACAGCCTATGTCTTTTGTGTTAGAGTTCCACTTTGAACCCAACGACTACTTTACCAACTCAGTCCTGACAAAAACCTACAAGATGAAATCAGAACCAGATAAGGCTGATCCCTTTTCCTTTGAAGGTCCTGAGATTGTGGACTGTGACGGGTGTACCATTGACTGGAAGAAAGGAAAGAATGTTACTGTCAAAACCATCAAGAAAAAGCAGAAGCATAAGGGTCGAGGCACTGTTAGAAACAATTACGAAACAAGTACCCAATGAGTCCTTTTTCAACTTCTTCAATCCACTGAAAGCATCCGGGGATGGAGAATCACTGGATGAAGATTCTGAATTCACATTAGCCTCTGATTTTTGAAATTGGACACTTTTTCCGTGAGCGGATAGTCCCGCGGGCTGTGCTGTACTTCACTGGGAGGCCATAGAGGATGATGACAATTTGAAGAAGGTGAAGAAGGAGAAGAGGAGGAATAGAAGGCGAGGAGGGAGAAGACGAGGATGATGCAGAAATTAACCCCAAGAAGGAACCCAGCCAGCCGGCGGAATGCAAGCAGCAGTAGGAAGCGAGGCGGGTGCCTGGCAGACCGACTGTCGGGACTCCAGGCCTGTGGGCGGGGCCCCGGCCTTGCCGCAGCACAATCCCGTCGACAGAGCTTACTCCATCTAACTCGTTTTCAAGTGCATGATTTTCACTTTCACTTTTCCTTTTTCCTTATTATTTTGCTTAACTTGTACAGTGGCAACTGAAATGCATTTCAGAAATAGGAGGTTTCGTCCAGCACCCTCTGCAGCCTTGGTGCCTGTAGCTCTGGACTTGCCTGGGCCCTGTGGGAGGGCCCCATAGATCACATCGGGGTGGGGGGGGGTCACTTGGCAAAAAGGGCCGAGGTCTGATGTGGTTCCAGGATCTAGAACCTCTCCCGCCCTCCTGCAGTTGGACTGAATTCTTCCCTTTCATTCGAAGAAACCCACTTGCTGTTTCCAGCTGCTTAATCTGCCGAGTGTGCAGCCTGCGTCACCTGTTACATGCTAATCATCTCAGAAGGGCTGTGTAGAGTAGCTGTGTTCTTCTTAGGATGTTGCTTCTTGATTTTCTTTTTTTAAGGGGTGGGTCAGGGTGTGACACACCAGCCCAGGCAAGAGCTGCTGCGGGTCACCTCATATTTATTTATCCCTTCTTGCCTGTGAGGACTGCGGCCTTTCGCTGTCACTCGTCCTTACCATTTCTGAACCACCTGGTGACCTGAGCGGGAAGAGGTGCCACTTCCTAGCAGGAGCAAGGCCTCTGCGGAAGAAACGCTGCTCCTGCCACCAGGGCTGAAGACGCGAGCCCGTCCTCGTGACGCAGGCGCCGCCCTGCTGCCGGAGCCGGGCTTCGGCGGTCTTCTCCAGTGAGGGCTGGGCTGGGAAGTCCTGCGTTTCAGTTGAGCGTATGAGCGTCAAGTCCTGCTTCTCAGTAGCCCCATTGCTGGGCCCCACCATTCATCCTGTCTGAAGGTCCTGGGTTTGGTGTGACCGGTTGGCGGCTGGTGGGTGGGATTCCAAGTGGGGGACGGCACTCTCCAGCAGCCTGGGGATGGCCGTGTCCACACCGACCAGGCCTGTGGAGAGTGCTCAGCCTAACCTTAGAACACATTTGTAACTGAATACAGTGTTTTCAATTTGTACAGAATAGTTAGAATATTCTATTAAAGTTGT + *%())'((((%()&()))'(#''%*62621241).40.-014200/536.+)-5/4495/03&4&31:9:59:05574998*3/42632,/2,/+,-85488089455477891-98/+67359'155203'*8(7469257//.2.522-.4555;8:844..03653(,1-)/%12,//133&-+1585.03)#23/22820.&#+'&&*54237765(1776451+#+6:-3324))*&3,7574/56*&*%-01.051626)2*1,2657151,658*34+5+93644,*43531(20&07,291481+&,15844.40+&314+2)33367828+5:43)1927/4664,511-5675726/7771464458/,0+&(++)14,066726605.:70242055/2648865/.*30-0/))*./)066464546*16(-94:9/84420/0/569.4;9:2:7247575861/78:8,0(832:675765507743:26340/)//53128515:2575/8,681693.,473477503/453/6146247(&1%02244'03234.83,-.5334:323,20./22//3/6972//+2,++27.02344'994982/254563,/0464*4+(20//)4566,7.21+25311+86/.1..-%,$)./+/.13131*13044-4704<.6>99<928=1=66661=::.;::737687;<834-+4-413;<9>;:89:7;::;.;92>27::940...#,,5*7366:58)5;;4&7626228:,*.3-4658%55930+96755=;7:835515:<;$070947;969:615<:99;<>217%233356;5555/8628.5332/375.,*1('*3+'+!,101+,40%./7374;55884649;==:==85?;?:>>>894<87>361>?,676&97945.38070(/33.74:377:527261/'$4:2474.26;7=7619824+6987:9::7,153987=3:/:6=?80843;-1-/*2!%./,630/4693/03)42-+622-2356.356/577:2;8:094)-54;;65=;99/8>;63(.6+04+98824)4586(1(6788-:,0&+849:8<)=8916289.:5648;;715<1;>==7.:=:5>>756>??>:4679?==;35:98/496474230.9776:2=6=51<603637=8:<7999686=<2&2?18;:6304--4140637+::7:72/1,545548+142693117%979285;87=:9:474/+5.30()1/1/3154-.,(&06026.2018./(98679,677,6927:48465;85846947023377586//5481//,266064*3)*567599:17./4666774527555998525,).32866391,769:/865,.2147924.,0+/,1/)/1.12)0/0.&215610/11+0+/,&-2,342.3-41/30/+.'220443/*)0)/4323'33,%%%2+-/54222+&,--./)0,1+4/32*.,,/010.),//.1-2.1%-,--)/(20331,,11..-./&-/132221122.32322/1/616563/5540/3235254/1)1036.5665/11.'1,,2)%'+-+.0,,-.10,0,213,63.56113..41000/56*'--0)54,,005231-1/-01+2+---1-1$%03.2//115-3/3-%/124664333(,06/*1631551.04+54212..-,0/100(.*$-,)/0$+-./2.33-,%$$&(&%&$+),*1(0,,('/..-+(,),/-)24061/1301-*53654-/51516443(3361.+/2-0/,+02/*043%.6264366///*&-.)+0,+0*1+220/000.50-1)+.,(**#0+032.(-/.%546,120./1.011,1//*.1$((52201./4+544041550.,-/4153225622.136/5/54111.-45545021*0120/1.2//*00-))422/1-12.,02//32.1.124-)/+/&,/.,)/230561522+11,4203*013,0.-12+)31+'00310,01*.1/12223 @rCer/2194/25_1601_CCS ATGGAAGAGCACCAGGGGCGGGGCGGGGCCGGCGTCGGGCTGCGGGCGCGGCCGGACGGGAGTTCCCGGAGAAGGAGCCTGCAGCCCGAGTCCCGTCCTCAGGCTACCCTAATCCAGGGACTCGGCGCCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGGAGGCAACGCAGTCGCCGTTCGCCCGTGGCTGGACAACACGGAGAATGATCTCAACCAGGGCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAACATGGGAATGTGCCCCTGCACTATGCCTGTTTTTGGGACAAGACCAAGTGGCAGAGGACCTGGTGGCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGAGAGAGCTTCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGAAATGGAACCCTGAACAAACACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAAGCTCAACGAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCCGGCTCAGGATTTTCTCGCATCCAAATGTGCTCCCAGTGCTAGGTGCCTGTCAGTCTCCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCCATATGGATCCCTCTACAATGTACTACATGAAGGCACCAATTTCGTCGTAGACCAGAGCCAGGCTGTGAAGTTTGCTTTGGACATGGCAAGGGCATGGCCTTCCTACACACACTAGAGCCCTCATCCCACGACATGCGCTCAATAGCCGTAGTGTAATGATTGATGAGGACATGACTGCCCGAATTAGCATGGCTGATGTCAAGTTCTCTTTCCAATGTCCTGGTCGCATGTATGCACCTGCCTGGGTAGCCCCTGAAGCTCTGCAGAAAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCTGATCTTTCCAATATGGAGATTGGAATGAAGGTGGCATTGGAAGGCCTTCGGCCTACCATCCCACCAGGTATTTCCCTCATGTGTGTAAGCTCATGAAGATCTGCATGAACGAAGACCCTGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTGGAGAAGATGCAGGACAAGTAGGACCGGAAGGCCCTTGCCTGAACTCCAGAGGTGTCAGGACATGGTTGGGGGAATGTACCTCCCCAAAGCAGCAGACCTCTGGTTGCCTCCCTGCCTCCAGTCATGGTACTACCCCAGCCATGGGGTCCATCCCTTCCCCCATCCCTACCACTGTGGCCCCAAAAGGGCGGGCTCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGGGAGGGATCAGCCCCGCCTGTCACAATAAAGTTTATT + KK%K@IDIKIKKKK2KKKJ:KKKK(KKK8I:JGEFKGKKKKKK=G?KKKJKAKKKDK8KG%KJ*HJ>JKIKKEJKKKKHDHKJ9KEHGKKKKKKIGFKKI7KIB7KKHKKKKKKKKJKKJKKKKKKKKKKJ-KKDBI>JGJEICFH?CJKKIKFGJKKKKKKKIKJK9KCKIKJKI=KKHKKKKA9KKKKKJIJG8K?2KJK(GEC(%KHBIKBKKKKKKKK1KHKKJB?KHKKKKI.KKKIGJIKKKKKIK0EIFJJG@KKH@KBKFKKKKKKK:HHKJKKCH?G:HJIKDKKK6KJKKD>JKJKKCKKJGKKKFEIK6IFJIKKKK6KBKKKH0K6KJJKKKKKJKK6KKJIK7KKI=G8IJKKKKKKKKK:KKFKKKJKKKGKHKJJKKKKJCIKKKKKKGKIKKAFKKKJKFKIKKKKKKKKKKHKKKKKKJKKKKKKKKKKJKKJJIKKKKJJKKKKKKKKKKK4KKKKKJKDKKKKKKKKKKKKKKKKKKJK5FDKKKIKIKKKKKJKKKKKKKKJKKKKKKIKF.KKKKEKKKKKKKFIKKGK(GJJKKKKKKKK@KJKKKKKKKKKKKJK%KKKJKKAKKJKKKKKKKKKKKK:KKKHIKKKKKKKKKKJF=6KIIJJJKKKJKKKKKKJFKKKBKKKIKK1KIKKIJKJKKKKKDCEKKK@KHKKKKKKKKKJ/IKKKJJKK?F=KKKKKKKKKKJKKKKH:KKHJKJKKKKKKKKKK(KKKKKKKKHKKJKKKJKKKKKGKKKKKKKHKKKKKKKKJKKGJKKKKKKKKKKKKKKKKDKKJKHKKKKKKKKKCKKJ8KIK:K@>KKKKDIKKKEKKFKGKJKJKKKKKKKKKKKKJFKIKJDKKJKKEKJKKKKKJKKKKKK=&KKKD>KKKKKKDJK7KKJKKK?JKK7KKKKJ?KKKKJ?4KK>KKKK7KKK5KHIKKKHBKKKKJKKJKKKK8CK=KKKKJKKKKHFJJKJKKJKEFKJKJKKJKKKIKKKKJKKKJJHJKI8KKKJKJKJKKKCIFIKKHKKKKK>KKKKKKKJKKKKKKDKKKKKKEKIKAKKKIKKKKKKKJKJKKKKKGKH5FIKIIKKKHGKIKGGIKGKKBJEKHGHKKJIKKKKHKKKKKFKKHKKFKKKKJKJKKKDKJKJKKJ@KHKJKKKJKKKK@KKKKKKKKKIKKKBKKJKKKKJKKIJKFKKKKFKKH8IJDG7H@K>KJIKKKJKJGKJKIHKKKKKKKKGBKIJJGKKK5KIKKKIKKJFJK(KJ@KKHJIBKK;KBKKJKCKKKKKKKKKKBIKKJGKKJKKKJKKKIKKKIKKJKKHKKKKAKK;KKKKKKKIKHKKKFKKJKKFKJKJKKHKCKKKKKJKIKK@KHKK?HJKKK2KKKKJKKK@KKBKKKKKKJKGJKKGJEIKBK>JKJ?KKAKDKKKKKKKKFKJKKKJKKJKHKFKKKFKKKKFJKKKKKKJKKJKKKKKFKKKKIKBKKKKKKKKIK(JKKKCKKIDDKKIKKKJKJHKKKJKAKKKIKKJKIKKIKKKJ@KIKKKKKKKKKK>KKKKKKKJKKKKKJK;KJIKKJIKHAKKJKKJKJKIIKJKFKKKKKJGKKIKKKKJJFKKKKKKKIFJKKKHKKKEKJKKKKKKKKKKKKKKHK:KKIKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKHKHBKGK5KKKKKJKJ>HEAEHJKKKDKKGJKIKJKKKKIKKJIKDKKKKKKKKKEKKHKFKK@KKKDJJKKKKKKJ?KKKKKJKKKKKKHKKJJKEKKGJIJDHKKDKKKKKKKK=KKKKKKKJKKK8KKKJKKKFKKCKKIIKKKKKKDKKKKJ@GKKGKKKKKKKKKKJKGKKKIIKGKJKKKHKJIKJKKKK:JKJKKK>KJKEKKJKKGIKK@KKKKKHKIKGKK9KKKKKKKKKIJKKKKKBHJJFGKIGEKKKKKKDKKKKKKGIKKKKHKKFKJKHKKKKKKGJC:AEFAF=?;BBC8CC@:3DEF@=F8>>A?AB.;>?98429=126=:FD*A<5BD?;D>?GE@CFFD?CE;EG>BE@B:BA2E@?@>:AEB>D>@CA-58:=F@>=9?E3E?DA=@CHE4@CACGDH>@?HC?@E6AEF@;=@E@I?HFC9?FEH@?A9DE>HIIIDFF7DFJ<9FDFG?>C>>:E>FAJG7F=FC/B9=?CAGCFFDHEE@D5BCBDDFII@DGBFHBGI?HG=C00@E;EAFFCG@CIG9GGFH:;HHCD7,BCC8CFFE?5@EA:DBDBAAGED<=EGBHD<6>FEC?:B;C&FFEC?CDDG;B5@?CIIIIHA8?=>AC=CE4FF+FB@CGAF@HAF=IEH;EDGHFD<>@4+AB@FHHE5@DAIGGHEDBAEHD)CCHFEAF@.?=FGIIIJIBHE8?F:=GHEIIB;?0CE:JH>IBHEGGBGHGDDDAICIFIIJACGH9DGE?F>:AC>EGHEGDH?CGD;HIIFEJ8FEIFHFFDFJGHIGCFFEGD>=IHFGFIEAI?BDHCFG7H@FGBDGHFEIEDFEE@HCFGIFDBCHHGJIIEBCGB>EGEEIIC>AHHFHI@HHF<=F@FHHDIHADGGIE@HBHFGBFGBDF>AFEEBC>FGE0E5;DCCGHG7ED;H=.CGFGC?DDBFDIFA;C:H=?CAA>CHFFH?CFD@HF@G=IICFF>EHCIBFDGG:FF:FHFICEGD>ACD5FJAHDB4C=>=HF<@&GCAH4CC;9:?15BDC@DGDCDI4GBDFDBEF5E?:7F>HE@?CAE8GBEFABIGD8GHGGAFDCJFECFBCCIGHHGIA8D@FCHADBHIGF5IG@EICFII?EGAECEHHIGIGCGD'DCD7BCD5DFGFFDH@HBC>HFIGDFEE;:;F@EFFHEG-EE?BGF0GIHHCIG1F.@EBCIEADCGBEEHIF?65BCD6HEIGIED:FHIHJIFICIJGJFIH;I>BED;GFFFC5EGAHFED;IBHF7F8AFIE;B>JHEKJKKJJG=FJI@JDJJH?;JHKJG:J?JJIHJDEFIKKGIDIJKK>EHB5FKIGJBF)JKHEGBA8IH>ACG.FHGACGHBHIGIBF?JGKJ=JIFIGKJIIKIJJKH=KI>DAJ?HHEF;=H@KJAJKHJECKIJI?KIJJJKD>HJ=HHJEECIJ>KJHHJIJJB?JKJ;J@J@GKKHEK8IIKGK@JJDICHKFHJJGHKFBKAJ?CAJ?J;JEBBC9?DGDDBEFJF:EFIIJHG=@=BA@IJIHKGBHDAHI@I@;FBFDIKIII @rCer/2197/2801_60_CCS GGACAGTGGATGCCGCGGCGTTGCTGCGGGAGCTTGGGCCTTCTCTGCTGCTGTAGCTGCCAATGGGCAAAAGAGACCGGGCGGACCGCGACAAGAAGAAATCCAGGAAGCGGCACTATGAGGATGAAGAGGATGATGAAGAGGACGCCCCTGGGAACGACCCTCAGGAAGCGGTTCCCTCGGCGGCGGGGAAGCAGGTGGATGAGTCCGGCACCAAAGTGGATGAATATGGAGCCAAGGACTACAGGCTGCAGATGCCGCTGAAGGACGACCACACCTCCAGGCCCCTCTGGGTGGCTCCTGATGGCCATATCTTCTTGGAAGCCTTCTCTCCAGTTTTACAAATACGCCCAAGACTTCTTGGTGGCTATCGCAGAGCCAGTGTGCCGACCAACCCATGTGCATGAGTACAAACTAAACTGCCTACTCCTTGTATGCAGCCGTCAGTGTTGGGCTGCAAAACCAGTGACATCACCGAGTACCTCAGGAAGCTCAGCAAGACTGGAGTCCCTGATGGAATTATGCAGTTTATTAAGTTGTGTACTGTCAGCTATGGAAAAGTCAAGCTGGTCTTGAAGCACAACAGATACTTCGTTGAAAGCTCCCACCCTGATGTAATCCAGCATCTTCTCCAGGACCCGGTGATCCGAGAATGCCGCTTAAGGAACTCTGAAGGGGAGGCCACTGAGCTCATCACAGAGACTTTCACAAGCAAATCTGCCATTTCTAAGACTGCTGAAGGCAGTGGTGGGCCCTCCACTTCCCGAGTGACAGATCCACAGGGTAAATCTGACATCCCCATGGACCTGTTTGACTTCTATGAGCAAATGGACAAGGATGAGGAAGAAGAAGAAGAGACACAGACGGTATCTTTTGAAGTCAAGCAGGAAATGATTGAGGAACTCCAGAAACGTTGCATCCACCTGGAGTACCCTCTCTTGGCAGAATACGACTTCCGGAATGATTCTGTCAACCCTGATATCAACATTGACCTAAAGCCCACAGCTGTCCTCAGACCCTATCAGGAGAAGAGCTTGAGAAAGATGTTTTGGAAACGGGCGTGCACGTTCGGGGGTCATTGTTCTTCCCTGCGGTGCTGGGAAGTCCCTGGTTGGTGTGACTGCTGCATGCACTGTCAGAAAAACGCTGTCTGGTGCTGGGCAACTCGGCCGTTTCGGTGGAGCAGTGGAAAGCCCAGTTCAAGATGTGGTCCACCATTGACGACAGCCAGATCTGCCGGTTCACCTCTGATGCCAAGGACAAGCCCATCGGCTGCTCCGTTGCCATTAGCACCTACTCCATGCTGGGCCACACCACCAAAACGGTCCTGGGAGGCCGAGCGAGTCATGGAGTGGCTCAAGACCCAGGAGTGGGGCCTCATGATCCTGGACGAAGTGCACACCATACCAGCCAAGATGTTTCGAAGGGTGCTCACCATCGTGCAGGCCCACTGTAAGCTGGGTTTGACTGCAACCCTCGTCCGGGAAGATGACAAGATTGTGGACTTAAATTTTCTGATTGGGCCTAAGCTCTACGAAGCCAACTGGATGGAGCTGCAGAATAATGGTTACATCGCCAAAGTCCAGTGTGCTGAGGTTTGGTGCCCTATGTCTCCTGAATTTTACCGGGAATATGTAGCAATCAAAACCAAGAAACGAATCTTGCTGTACACCATGAACCCCAACAAATTTAGAGCTTGCCAGTTTTCTGATCAAGTTTCATGAAAGGAGGAATGACAAGATTATTTGTCTTTGCTGACAATGTGTTTGCCCTGAAGGAATATGCCATTCGACTGAACAAACCCTATATCTACGGACCTACGTCTCAGGGGGAAAGGATGCAAATTCTCCAGAATTTCAAGCACAACCCCAAAATTAACACCATCTTCATATTCCAAGGTAGGTGACACCTCATTTGATCTGCCAGAAGCAAATGTCCTCATTCAGATCTCATCCCATGGTGGCTCCAGGCGTCAGGAAGCCCAAAGGCTAGGGCGGGTGCTTCGAGCTAAAAAAGGGATGGTTGCAGAGGAGTACAATGCCTTTTTCTACTCACTGGTATCCCAGGACACACAGGAAATGGCTTACTCAACCAAGCGGCAGAGATTCTTGGTAGATCAAGGTTATAGCTTCAAGGTGATCACGAAGCTTGCTGGCATGGAGGAGGAAGACTTGGCGTTTTCGACAAAAGAAGAGCAGCAACAGCTCTTACAGAAGGTCCTGGCAGCCACTGACCTGGATGCCGAGGAGGAGGTGGTGGCTGGGGAGTTTGGCTCCAGATCCAGCCAGGCATCTCGGCGCTTTGGCACCATGAGCTCTATGTCCGGGGCCGACGACACTGTGTACATGGAGTACCACTCATCACGGAGCAAGGCGCCCAGCAAACATGTGCACCCTCTCTTCAAGCGCTTCAGGAAATGATGCTGAGGCGGGGTACTTCGTTCAAGACCGGCGCTTGGCACCCTCGTTGGAAAGGGATTTTCAGCGTAACGTTTTCCTTCGACCTCCTTGACCTTCCCTCCAGCGTTGGCCAAACTATGCTGAGGAAACTGCCTCAAGGGCTTGGCTCTGCCTTCATGGGTCATCTAGGGTTTATTGTCTCCTCTTGCCTTTATCATCTAGGAGGAGACAATATTTTTTCAAACTTTTTGGGGAGTGGGGTCATTTCTGTATATAAAAAATTTTAATATTTAAGGTGTATTTATCTTACTGTTCTGAATAAACAGAATGGACCATTGAACC + &#%(((%&%()()(('((+*(%+,')+&''*--*+-+&()-,-*++'-/1)12-)7/52483&96104620-77479574*/3111-8/2086337+543159586:95)1;771400778926075+65433853%-8488827854452,.0*../:5;;89:9;7=2;:<:?<64.7655=:96613.:;0;;;.155585027:/:533:7>>4=;6(*-<=56<88'/888:8?;;85;75>6.*7393/39?<;7039&;76<6<947:6<78=8/?36:6,67=<=3:>88;=6:8><:0887:4:8;<=8/869<:?9<0(*+386=>:47&==<6;:798:=2:7//8;69=/=:49/2575<>:::>687.1464/=<>69-=;?=;7=8=;:7<952765//.398019:0<97482=52081:=<;109=<<15;<<97:;6:;=6576'585786::2656;78484<6758564=9:7<3;=;<37;>;;;:;8;<4;776;86/?8208<<33<7.9-854-%1+597<<:/-663:;==9:=;%:96:5==/5/-/>999:;:86;0=;<;.+:<0996/8:;688-2:+9;;3465879;;=<====39;;8=866=>:2;?298&7;<:4998>8:==878=9=2;5<2>7<:=;<7>>2<73?:;;58<=:=:=?<2>>6=9>9:>/9*8;66;:=66898-66>=.;8=18942:801:(7336;8;899=6==:>:578;/-<78:91<:65525457595:2><<97<,8352:653=>98<>7,74:5366::5-97991:4:9:96:575549/7/9968:55:3422569436654//848878-865554;::::6145(/185428857087838987/48/351186354/551166(9;6:485999.95854354.7:;89796115625:9/7660.44057374:89089;797;15;;78;:'5860426:9:9997:294:9:6-0059796553916:58825797541%4011%13..544.00363.06638050-0.79332$26454,1.54968:,1'5454-644612/02+/13-21)-+%3956:943.322545.49::8(64897682:82564846504'556*7-&*2+51::9:;9:;47245589/:;898/87:08745;98423/78898599862-89::,8551999.9957:47;292;996509;;4/4:928/479:/65.59533-554:;4:8534:62::6534943)/:8:;8777&9;5+:8162'8977596532-1334/972259688597:785-8;64:656;500:4486149857528:;7545-32-)411+1-+35+813183:4.18647609615::36.86628827046054794;591/98530-4544583+23%7697;53639/36:93681963&/01.4327:9-031+.2698138/4&4762/333+59733/06&7960435/5892,'-85244/34-884:5-35:437/83;:81/4979:99:18949314;;6345526566/67/6;:3&3,47,7822576:49965::9728-85:;;7:87.59;7372486759592061:;:48035807832675:759:389216%898:753*013.466:;;9661;8982:::69868-123(56220.96329:94:4637749975:763;0;8/718;6:9354,1695'615(57.44814790477:;79986/$75/5:66426578827474/7.546814;6;;68713668:55:6-702*:.6%2782.58;38561$#76:46382;7:75707408299379:7:66.5:759364.:908,-614)93(1457963724/259575607576.+086:65:2964,7727489887156448308.96456227867/56334617'38920829744::7457//463+5:852236:98453/8089265::885;9694954572+/1.8090;76874747)088/06/325240177-945145+775,28.3068:6:4::;484;5670;8258;6:;9:657*5815.0*35::7447899::2793/6698598/5415-86747159.5777)59-1196478:89385961.9975264.8254506(5:65133-)1176'51,6;9:803;:74:729'5:6489461:998/3.81:98/4373111.645:299;4:55343.8::914302:929*/5956516980640/-'.668273488/29:/7:161230,9:9439049;:9:/66799587489;6950*471638,86.3)3/3439::16;7:792,364/7/55:471+5287/3283).6+4314'9:233452:7998-7271658939969/459962:4677.4:7/7/989897,796913101-)10&55597889164+5.410+/::563769:59:/5999:9:47765/771334884249&492;834189495855995:64*30.)24450+-.5.24056-411)/31332*.1*4,150-+'#%)55524-422-6124510422,5-.$15-2214120*(1)+/1/(244.02/0'*52(2)01552/5- @rCer/2198/1962_63_CCS ATGGGGGACGTGGGGAAAAATCCATGGCGGGGTACTTGAAGCTGGTGTGTGCTTCCTTTCAGCGCCAAGGGTTCCATACTGCTGGGAGTCGCTGCAAGAATCGGACAGGCGGCTGAGCACCTGTGGCTGACTCGGCATCTCAGGGACCCGTTTGTGAAGGCTGCGAAGGTGGCGAGCTACCGGTGTCGAAGCGCCTTCAAGCTCCTGGAGGTGAACGAGAGGCACCAGATTCTGCGACCTGGCCTTCGGGTATTAGACTGCGGAGGCAGCTCCTGGGGCCTGGAGTCAGGTGGCGGTGCAGAAGGTCAATGCCGCAGGCACAGATCCCAGCTCTCCTGTTGGCTTCGTGCTTGGGTAGATCTTCTTCACATATTCCCCCTGGAAGGAGCAACTTTTCTGTGCCCTGCTGATGTGACTTGACCGAGAACCTCACAGAGAATCCTCGAGGTGCTTCCTGGTGGGAGAGCAGATGTGATTCTGAGCGACATGGCGCCCAATGCCACAGGGTTCCGGGACCTCGATCATGACAGGCTCATCAGCCTGTGCCTGACCCTTCTCAGCATGACCCCAGACATCCTGCAACCTCGGGGAACATTCCTTTGTAAAACCTGGGCTGGAAGTCAAAGCCATCGGTTACAGAGAGACTGACAGAGGAATTCCAGAATGTAAGGATCATCAAACCTGAAGCCAGCAGAAAAGAGTCATCAGAAGTGTACTTCTTGGCCACACAGTACCAGGGAAGGAAGGGCGCTGTGAAGCAGTGAGGATTTCTCTGTGCCATTTTCATAATGGTCATTAGCTTCTTTTTAAGCTCGAAACGTAGCCTGAGCTCCTTCCGGAAGAGTTCCTGGGAGATTCTGAGCTGATTTTGGAGATGGAACAGGAAAAGTGGGGAGTCTCTTTCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCGCGATCTCCACTCACTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGTGTGGCTGGGACTACAGGCGCCTGCCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTATTTGGGGTTTCACCGTGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCATCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCTGGGAGTCTCTTTCTTTCTCTCTCTCTTTTTAACCAAAAAGAGATGACAAAACTAAGTTCAGGGGCCATGGAAAATGAAAAAAGTCCTCTATATTGATTTGTGAAGAGAAAGTTATCAAGAGAAAGAGGTGAGGATGGAAGGATGAAGAGAGACAGACTGTGGGAAGAATCAGAAGGAATCCGCTGAGGCAGGGATGGGTGTGCCCATGTGTGCCTTGACGGGACTTCATCTTACAGACTGTTAAACTGTCACACAGAAACAGGCTTTCCACTGCTCCTCCCAGAGCACCATGCACAGGTTTTCCAGTTCTTTAGTGTGGCTATTTAAAGTAGAAAATCTGGGGCTGGGTGAGGCCACTCACACCTATAATCCCAGAAGGCTGAGGCTGGGGGGATTCTTGAAGTCAGAAGTTCAAGACCAACCTGGGCAACATAGCAACACCCACTGTCTCTACAAAAATGAAAAAACAAAAAACCAAAACCAAAGAAAAATCTGAAAATTTCCATCTGGGGATTAAATTCTTTCTTTCTGGTGAGTAATCTAGAGATTCATGCATTCTTTCAAGCAGCAGAAGTTCCCAGAGCGATTAGGGAAGACGTATGGTCTGAATTTACTCATGCACTGGGTGTGCTTTTGGTTTTCGCTGGAAATTTGTATCTGTGTCTGGACTCCCAAGAACATAAAGGTAATTGCC + 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@rCer/2200/25_2220_CCS ATGGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGCGGGAGAGGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTAAGCCTAAAGAAACTGTTCCAACTCTTGCTCCAAAAACTCTTTCAGTAGCAGCAGCTTTTAATGAAGATGAAGATAGTGAACCAGAGAAATGCCTCCAGAAGCAAAGATGAGGATGAAGAATATTGGAAGGGATACACCAACATCAGCTGGACCAAACTCCTTCAATAAAGGAAAACATGGGTTTTCTGATAACCAGAAGCTGTGGGAGCGAAATATAAAATCTCATCTTGGAAATGTCCATGACCAAGACAATTAAATGATGTTTTGAAATTGGGGTGTGGGGTGGGTGTAAAGTTAAAAGGAACAGTTTCCTTTTTTAAAGAATGGTATAAGACTATCTTTGGAGCCGCTTTTTTTTCTTTTTCATTTTTTTAAAAGATTGAGTGGTACACTAATAAATGAGAGTTTGAAATTAGAGGTAATTTATGTTTTATATACAGATTTCAAGACATTTGCTAATTTTGTAGTTTCATGTGATTAGTTTCCAAAGGTTACAGATAATAAATCAGAAATGGTACCTTTTTAAGAATTGCATATTTTTTTAGACACAACTATTAGCACATTAAGAGGGAAGCAAAAAGTTATTGTCTATTTAAAACTGCAAGCAGTTACTCTCTTAACTCCCTTATTACCTAAACTTGTCTGGCTCCCAGGAACAGCCTTATAGAGAGAGGGAGTATTGTATTGGAGGAAGATGTTACTGAACTATTCACTGAAAGTAAATTTAGATAAAATACAGCTTTTTTCCTTATGGGCATTTGTTTTGTTTCAAGTCATCATAAACTAGATATTGCATTGCTATCAGTGGATACAGATGCTTAGCTCTTAAAAGAATTTTTTTTTTTTTAATGTAAACTGTTGAATATTTGAAATAGCCCACTTCACCTTAATGGGTCTTGTCTATCTTCATTAGTCTTCAAAGAAAAACCATTTGCTACCAAAGTAAATCAGTATTTTGAATGTGCTTCTCCTGTTTTTTGTTTATTAGCTAGGTCCTGTAAGCATTTCCACCAGAACTTGAGGCAAATCATAAGGAAGCTGTTTCTTTTAAAACACAAACCACCACCAAAAATTTAAATGTACATATTGCTTAAATATTTGGCTGTTTTTAGTTTTTAAAAGGTATAAACACCAAAAAAAAAAAACAACATTGTATGAAGATGGAAAACAAGAAGATGCACTTTCTGTAGCCTTGTCTAAGGATTTAAATTACTAACTTGTGAACTCCAATTTGAATTGAACTTAACTATCAGCTTTCTTACTAGTAAAATTGTATGGTTTATGTTAAATACGTACATATTGACCAATGGCCTCTGAAAAAGCACATTTTAGATTACTGAAATTGAAGGAAAGAAAATGCATCTTCAAACATTTTTTGGAATCTCACCACATGTACTTTGTTAGATTTGTGTATTGTAGGGTGTTTGTTTTGTATTTTTGTATTGTATATGAACTTTTTTTTAAATGTGACAGTTAAACACATCTTTAAAAGCATAGTCACAGACAAAAGAAGCATACAGTATACAAATTTCCTTGAAAACTCCTACAATATTATATTTGGAGGCAGCTTCAGATTGTTTTATTGGTGGTAACTGCTTGCTGAGTCTTTTAGTTGGTAATAACTCCAGAGAAGCAGCCTGTGTATATTCCTAACGTTTTGTTCACTAGCATTTAAGTTTAGAATAAGCCCAAGTAAAACGATGGAAATGTATATAGAACTCTTAGTTCTTACATGATTTAATTATATCAAGATACATGAATTTAACTTACTTTAATGTAGGCAAACTATCCATTTTTTGTCCATTTTCCTGTTTGTTAAAATAACATACCTCTCCTACGTATTATTTTCTTGACCCAAATGAAATATTAACCTAAGGTCAAGCTGGGAGAGAGAAATGACTGAGATGAATGTCTTTACTAAAGTACCAATAAATTTGTCAAACT 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@rCer/2204/25_1962_CCS ATGGCTGGGAAGTGGCCAGAACTGCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCACGTGGGTCTCGAAGACCCTTGACTGCCTCCCCAATGCTCCGAAGCCTGAGCTTCCAGGGTGGCCCCCTGACCACCACCACCACCACCCCCACCCAACTGGGCTTAACGGGGGAAGATTTCCCCTTTAGATCAAACTGCCCCTTCCATGGAAAAGCTGGAAAAAAATCTCTGGAACCCATATCCAGACTTGGTGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAGAGCCATGAGTCCTGGAGGAGGAGAGGACCCCTCCCAAAGGACTGGAGACAAAACCCTCCGCTTCCTTGGGTCTCTCCAAGACTCCCTGGGGCCCAACTGCGTTGCTCCACCCAGACCCATCTCTCCCTTCTAGACCTGAGCTTGCCCCTCCAGCTAGCACTAAGCAACATCTCGCTGTGGACGCCTGTAAATTACTGAGAAATGTGAAACGTGCAATCTTGAAACTGAGGTGTTAGAAAACTTGATCTGTGGTGTTTTGTTTTGTTTTTTTCTTAAAACAACAGCAACGTGATCTTGGCTCTCTGTCATGTGTTGAAGTCCATGGTTGGGTCTTGTGAAGTCTGAGGTTTAACAGTTTGTTGTCCTGGAGGGATTTTCTTACAGCAAAGACTGAGTTCCTCCAAGTCCCAGAACCCCAAGAACGGGCAAGAAGGATCAGGTCAGCTGCTCCCTGGAGACACTTAGCCTTCTGACTGGGACTGACTTGGCCAAGTTCTCAGCCGAGCCACGCGGCTGGTACTGCAGCCTTCTGTGACCCCGCCGTGGTAAGTCCAGCCTGCTGAGGGCTGCCTCTTGACAGTGCAGTCTTGTCGAGACCTAACGCCTCAGTCTGCTCATCCGTAAAGTGGGGATAGTGAGGATGACACCCCTCCCCACCACCTCTCATAAGCACTTTAGGAACACATAGTAAAGGGTAGGGAGAGTGGCTCTGGCTGTGTGTCCTACCCCTTTAGTGTCCACCCCCATCCCGGCTTTCCGAGCTGATCCTTGAAGAAGAAATCTTCCATTTCTGTGCTCAAACCCTACTGGGATCAAACTGGAATAAATTGAAGACAGCCAGGGGGGTGGTACAGCTGTGAAGCTCGGGCTGATTCCCACTCTGTCCCAGAAGGTTGGCCAGAGGGGTGACCCAGTATTCAGTCTTCACTATAACTCTTAAGAGTTGAGACGCTAATGTTCATGACTCCTGGCCTTGGGATGCCCAAGGGATTTCTGGCTCAGGCTGTAAAAGTGAGAAGCTGAGCCATCCTGCCCATTCCTGAAGGTCCTACAGGTGGAACTGCAGGAGCTCAGCACAGACCCAGCTCTCTGGGGCCTGGTCACTTGGTGATTTCAATGATGGCATCCAGGAATTAGCTGAGCCAATAGACCATGTGGACAGCTTTGGCCAGAGCTCCCATGTGGCATCTGGGAGCCACAGTGGCCCAGCCACCTGGCTCGGGCTAGTTCCAAATTCCAAAAGATTGGCTTGTAAACCTTCATCTCCCTCTCTTCTACCCAGAGATAGCACATACGTGTGCACATGCATGCACACACACATTCAGTATTTAAAAGAATGTTTCTTGGTGCCATTTTCATTTTATTTTATTTTAATTCTTGGAGGGGGAAATAAGGGAATAAGGCCAAGGAAGATGTATAGCTTTAGCTTTAGCCTGGCAACCTGGAGATTCCACATACCTTGTGTATTGAACCCCAGGAAAAGGAAGAGGTCGAACTGACCCTGCGGAAGGAGCATGGTTTCAGGAGTTTATTTTAAGACTGCTGGGAAGGAAACAGGCCCCATTTTGTATATAGTTGCAACTTAAACTTTTTGGCTTGCAAAATATTTTTGTAATAAAGATTTCTGGGTAATAAT 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@rCer/2206/25_1928_CCS ATGGGGACACAGGCTGAGTGCTGCGGCGCGATCCTCGCTTACGTGAGAGTTGGCCCGGGAGGAAAGATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATTCGAGAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGACAGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACGATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGAAGATGATGAGTCTGTCCAGAGAACGTGTTGAATTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGACGAAGCCATCCTGAAGTGTGACGCAGAGCGGATAAAGCTGGAAGCAGAGCGATTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTGCCCATCAGTAACGATGAAGATGCGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACTGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACACTCCCATTTATACCCCCTTTTTCATGAGAAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATCGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCACGGCCGTGACACCTGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCACATGACAACAAGTCGTGGGAGATGTTTGAAGAGATGATTACCACCGCGGAGGAATTCTACCAGTCCCTGGGCATTCCTTACCACATCGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGACCAGGAGCCATCCAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCGGCAGCAAGAGACGTCACCCTAGAAAGCAGGCTGCAGAACATGGAGGTCACCGATGCCTGAACATTCCTGCGTCCCTGTTTGCTTTCATTTCTGTCCGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCGCCCTGCCCCCATCTGACTGTGGAGCTGAGAGGGGAGCAGTGCCATGTACCACACAGATGTTCCTGTCTCCTTGCATGGGCATAGGAACCCATCACTGATGACTGATGAAACCATGTAATAAAGCATCTCTGGGGAGG 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rCer/2208/0_15803_CCS ACAACACTATCACGGAAAAGCGCTGCTGAGGAGTGCAAGTCGGACGTAGTTGAAGGCTGCTCTCGACAGTACATCGAACGTGTGCATCGACTGTTGAATAGGATTTGCTGGCCAGCGACCCGTGCTTCCGTCTGCTCGAACACCATGCGAGGCCACTGGTAAAGCTAAAGCTGCGTAAGGGGGCCCGTGCAAACCACAAGCACAATAAGATGGCGATCAATCCATTGGCGCCTCTCACAACTCTCTCTTACAGTGCTTTGCACTAGTATACAAAATGTGCCATTTTAGTTACGCTTTTATGTGAGGGCACGAGGGCGAGCAGGGAGACGAGACCATGTGCGCATTCTGCTTCTCCGAATAAATATACTTCATACTGACCGCGGGTTATCTCATCTCATATCCTTGGAGCTATTACTGCCATTCCAGTTTCTGAGGAAAACAAGTCTCGCGTGACAGCTGCTGTTTGAAGTTCGAGGCGCTCACGCTTCACCCTTATGTCTCCATGTTCCTGAAACAGGCCAAGATCGAAGTGTGCCAACTCTCACTGGCATGCGCGGTGGCAATAAGACCGCTTGGCAGTTGTCGAAACCCGCATACCTTGGACTCGCACATCCTCAGTCACGTCACAGTTGACCACAACCCGATCGTTGCCGAGGCTGACGAGAGAATCAACGGCCATAGGACTGGAGATGCTCTAATGAAAGGATTTGTCGCATGGTCTATGTGGCAGACTTCTCGCCGGTCGAGTGATCTCCTGCACCTGCGGCGCATTGTACGGGCGACATAAGTGGTTTTGTCATGATTGTGTATAGGAGGGTACTTTATCGTGAGTAAGCGTCGGTAGTAACACAATGCCTGCAGTACTGCATACGTGTAGAAGACTCTAATCACGTAGTAGAATCTCATTACTCCCTTGTTTGATACTAGGTACAACCAAGAACACACTTATCTGTCCGACTTTATCACCAGTGTACTAAAGCCTTGTCCCATGGAGGCCCCGAGACCTTAGAGAACCGTAGACAAAAATCTGGTCCAGTAACATATAATCCTAGCCCCACCCTTGAGGGCCAAACAACACTTACTTTAAGTAACGCCACTCAGCAAATCGTCAAAAGTGCGGCGTATGTCCCAGAGCGGAATGCTACTTCCTTCTTCTTCCTTTTTATTACCCCACGTATTTTGACCGATTTCCCACTCTCACTTGAGTATACCTCTCTCCTACATTCAAACGCGATGTGCTATGTTGCTGAAATACCAGAGCTGTAAGAATAAACCCACTAGGGCCGCTAGAAGGTCGCCCCGTAGGTCCCTACTTAACGGTGAGGATCTCGTCCTCTACACCATAAACTCGCTAGCCATGCCCAGCAGACACCGGCGTGGGAGTCACCGCCTTCGTATACCTCTGACAAGCCTGTAACCAAGGTACACGCGCAAAGATTACCTTAGGTAGCGTACGAGCAGATACATTAACCAATACGCTCTGTGATCTTATTAAAACCACAGCAAGACCCAACTACCGCCAGTCTAAGCAGCAAGGCCGTTCCATTAGGACCATCGAGACCTCACGACTCACACAACTCATTAGCCACTAAGAAACAAGAAAAACTACGACCCTGGCACCCACTCCGTATGATAGACCCCAGCACCCTAAAACATACACACCCGAGACAGTGCACCTGGCCATGCTAAAACAAAAAGCATAGGGAACTACTCACACACCGACATGCAAAGGCACTGCTATAGGCCGGGGCGGAAAGGCATAGACCAGAAGGTGGCTGGGCCACAGAGGAGGTATGAACAACCCGTCTATCTCCTCCGAAACACTCAGGAAGGTGCGCAGAATCGTACATCTGCACACTCCATCTGTCCTCCAGCAACCACGCACACTCCTCTAGATAACCTGAGAGGCATCGCGAGCAAGAAGCTCCCAGTCCACTTAAAGTGCCGCTATTTGCAGTGACATATCACTAAGACGCTCTCTGGTAGAATTTCCAGTCTCATCAAATGAGCGGTGTGGACGGGAAGATATAACCGGACGTAGCTCTCCTGGCACCGGACCCATGCTCACACTCAGGTGCCTCGGTCCCTGACAAGGACTTAGTGTTATATTCAGGCCCTTTGATAAGTTGAGTTGTTCAAACTCAAAGGCCCGTGCTAATAAGCGGCTAGCTGGCGAGTAACTCATATACGCACGAGTACGATGGGGGGACTCGCGCGCACCAGGCCTCAACGACTCCCATCGGTGCGGACGTCGTCCCTTTGCATTGCATCGCATCCCAGCTCGCGCGTTCCTTCTCTACGCGCTCTCTCCTCCGCCTCAACACTACCCCTGGCCCCTACCTTCCTCCGCATTGTGGGCCACGGTGCTAGTCTAGGCCAGTAGGGAAACCATCTCCGCCATTTAATCGCACGTCTGAGCGCGTAACCGGGCGGCGGCGGCGGTGGAGGGCTCTCATCATGGCAGGGACGAGGCGGAGGAGCACAGGCGAAAGCCCAGGCGTAGGAGTCTAAGAACCCGAGCCTCCTCGAGCCCACGGCGTGCGGGTTCGCGAGGTGGAAGGCAAGCATGAGGGAGATCGTGCTCTCGCCAGACACGAGCAAGGACTGGCATAGAGTATCGACCTAACCCCTAACACTCACCTACCTACACACTTTACACCTAACTTACCTCTACCTAAAACTACGACCCCACTACCCACCCCTAACGTACAAACTATACTCCACTCGCAGCAGCGAGCTCGTCGCCCTCCTCGGCGTCATTCTGTACAGCCCGGGCTACCGGAGACTTGCATCCTGCAATCAGGTCCTCACTGGAGAGCTGATCAACCCTGGTCTAGACATACATGCACTACTACCGTCGGCTGCAGCGTCACGGCGCGCATCTGTCTACCCCATCTCACGGCATATGGGATCTAGTGCTGTGATATTGTTATTTTGGCAAATGACTTTGTACATGTGTACAGATCAATTCTGGTGCACTAACCATGGCTAAACAATCCAAGTCACGCCCTAGTGTGAGCCAGGTGTTCTAACAACCAAGGAAGACTACACTTGCAGCTTCATATGTAATGCCTCGTTTGTTATATTTGAGCTCCATAGGCCTATAAAATTCTCATAAAACCTGAAATTGATCACTATCAACGTGCCAGTGGACTTAAACCATCAATGGCGCTGTAATCTTCTTTTATGAGTTACTGTGACGTACACTTAGCAGGGAATCCTCAAGATAAATAGCTAATCCTGATCTGATCACTAAAGACAACACTGATTCCAATTGACTCAAGATCTGTGTGGCTCCTCTCAGGAGACTAGACTAATTCTGGAAAAGCGACTGGAGAAGAAATATCTGATTATAATCACTAAAACTCTGTTTTACTAATGACTTAGGAAGTGCTGACGATCCTGACGCAGGACTGCAAAACCCTCAGTATCTATACATTTGATGGAATGGTCTCCGCTAGAATGGTGATATACTTATGCTAAACTTGCTGGACAACGAGAATGATTGTCTTTGAAAAGTGTGGTATCACTATGACCTGTTGAAGAGTTCACATCTTATCTACGCCTTACCAAGGCATCATCATCGAAGCTATGAAAAGGCAGAACATGTTCCTCTACTCACCCATTTTCCCTCCTTTATACAGAAGCACCATACTTACCCACTCAACTCGAGCTGTGACAGGTTTTCATGGAGATAACATACATAAAGACAAGTATAATACCCTACAGGGGTATTCTGATCTGTAATGTCGCTTATATCACCACCAAACTTCACTGTCATATGGATGCTGTAAGCCGGCATCCTGCGCAGAAACCTTATTACCAAGAAGACTAGTCATTTGGCTTACTGTGAGCAGACTTATAGTGAGACTGACCACTTCCAGCATTGCCAGCAACCTTATCTCATGCTTGGAAGACACAATAGACAGAATCAAAGCACTCCGCTCTTAACGCCCAATAACCACCATTTGAAAATTTAAGGTTAAAAAGCGAAAAGAGAGGTCACATTGTTCAATTGCTACTCAACGCTCTGAATTAATCCATAATCCCTACTACCATAAACCACTGCCGAAACCAGACATTCAACCCCACACCCTCACCCCTAGCCAATAGCATGCAACGTTTCAAAGACACATACATTTCCCACCACATGCTACAAAATGCACTCTGTCATTTCACTTAATGCAGCACAGCATCAACCTATGCCCAACATGTTAATATTCCATATGTCTTGTTGGCATCTGCACTTATACATGTATGATGAAAATGGAATTACGGCGCGCTTTAGAGTAGTTCATTTATAACCAAACAAAGCGAATTTCATTTCTTACAAATCATCTAACCAGAAACTATTTAAATATCGCTATCTAGTTAGCGAAAACTTTCATGATAAGCAGCGTAGACTCAATGAAGTGATGACTGCAGATCAGAGCACAGCATGAGGAACATTCCACAGGCAAGCGTATAAGAACCGGGTTCTACATATGAAACATTAACTCATGAATTTATCCCTGGATAGAGAATCTGAAGGCATGGTACAGGACATCGGAACATGAAGATGGAAGAAAAGAGAAGACAGTCCTAACTATATTCACGTACTATGTGCTCTATCTCAATGCCTACTGCCACGTTCGCTTGTATTCGGAAAGACTGAAAACGCTGCTAACTAGAATGGAATAAGATCCTATATGCTTTTACAATAACACTCCTGTAGATTTGGTCCATTCCATAGTAGCTGGCACCTGTTACCACTGTACTTTGGATGATTTATAATCCTGGAATATTTAGCAAGTCCAGGTATATTTTTAAGTTGATGAATATGGTTAAACTTACATCTCTTTCTTCCAAAACAAATACTAAAAAGAAAATAAATGGCTCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTAACTCTGCGCTCTGATTACCACTGCTTAATCTTCTTCTCAACACAACGACTAAAGGCTAGAAGAGAGAGCGTAAAAGATTGAGCTTGAGATTACACTAGCAGATGGTATACTAACGCGAGAGACTACTTTTATCTCTTTTTAATAATACTTTTTTTATTTTTTTGTTTTCCAGCATTTAATCCTTATCTTTCCTATTGTATCTTAAGAAAACTGTATAATATCCTATTTCATCAATAAAATACAATAGCCTGGACTTGTCTAACATATTCCGGACTTATCTTCATATCCTAAATACTTACACTATCCAACACACTAGAAAGGTACTAACTCTACAGTGGTTATCCTTGACATAAAAAAAGCATATCAGGATTCTTATCACTCTCCATTCATTTAAGCGAGCGTTTCAATATCTATCCGTATAAAACTGCAGAACTGTAGGAACCAGTGCATTGGCCTACAACCACTACTTAACTACTAAGTCCGTGAATATAAGCTTTCATGTACTTCCTTCTCTTTCTCTCATCTTCATGTTTTCCGATGATTCCCTGTAACCTGCTCAATTCTCTTCTACTTCCAGCTGATAAATCATGGTCTAATTTCTCATGTATAACCCTTCCGTTCTACTATCACACTCCTCACTGAGTGAATGTCTCTACATCTTCTCTATCTGCAAATCATACATTCACTTTCAGATCTATGCCTTATCAGCACTAAGTTTATCCGTAATCTAACATGCATAAATACTTAATCCTGTAGATGACGTTAAAAAATGAAATCTTGTTTGTGTTAACAATGAACCATACAATAATGCCCCATTTCCATCATCCACACCATTTAAATAACTAGTAGCAACCAAGACAATTGAATATTCTGTGGCAGGTGATGCTTGCTAGACTATAATTGCTAAAATGACAGAGTGCATTTAAGCATGGTGAGTAAAACTGTTATCCCAAATCTGCAGTTCATGGAATTAAGCATCTTGTCATCGTCGGTGCATTATAAATTTCTAGCGTAGAGTTACTAAGAAACAGATGAACCTCCTCTGTCCCTTTCCACTTAACCCATTTTTCACAAATTGATGCTTATTGTCTCAAAGAGCAATGCTGTATTCTGTCTTTGTGCTTCCATGCATGACAAAGTTATCTGCTTGGACATGATGCTGAAGTGGTACGTCTCCAATCTGCTCACCCAAACCTTTCTAACAGACAGTTCACTTACTGGTAATAAAACGTTCTCATGCGCTCCAGAGCGGTCACACACCAGTCACCTATACGACTATGAAACGTTAAAAATCTAACACATTACAGACAGATAACCCCATGCGGCACTATATACCTATGCTATTTTACGGCCATGAAAAACCGTCCACAGCTCAAGTGGGAAATTGTACCATAATACTAACAAGAATTGAGTAAGAGGACTGTCTCCTTTTTCACTTAACTATGACTGATACTCCTGGAGCGATATAATCTGAATGATTCCAACAGTCAATAGGATAAACCACTAACCCTTAAAACTTCTTTACTAAAACTACTCTACTACTACTACTCTTTCAAAGACAATCATCACTAACTCCTTTCCAGCGAGTAGCAAAATTATTCACAATCAGCGTGAGACATTCCATCAAAATGTATAGATACTGTAGAGTTTTGCACTGAGCCAGAAACTCCACTTCCAATCATTTAAACAGAGGAATTTTATTATCATTTCTTCCTCTCTCCAGAATTATATCTCCTGGAGGAGCCCACAACTGAATGGAATCAGTTCTGTCAACAATCCTAATTATCTGAGATCCCATGCCTAAGATTGTACGTCACAGAACTCAAAAAAAAAACTTGCCCAGTTTTAAGCACTGGCACTTTGATTAACAATTTCTTTTATGAGATTTATGCCCAAGGGCTCAAATATACAAACAGCATAACCGATATGAAGCTGCAATTCCTTCCTTGTTGGTTAGAAATCACTCCCAATCACTAGCTGACTTGGATGTATTTTCCACCATGCTTTATAAGCACCAGGAAGATCTGTACACATATTTCTAAAGTCTATTTGCCAACATAAATCACACAATATTCACTAGCCTGATCCATCTATGCCGTGAAGGGGACATCCCTCGACTGCTGCCCAGGAGTAGCTAGTTGTCTCCATGACTCTGGAGCCTAGGTTGTACAGCTAACCAGTGAAAGTAGACTCTACTGATGCAGAAATGAACATCTCCGGAGTCCGGGCATCTAACCATAATGCGCTGAGAGAGGGCGACGAGGACCCCGCGCCCCTCGTCCCTCCTCAACGAGGCTTCGCGAGAGCCCGCTTCCCTCATGTCCCTTCGGAAACCCTCGCCCCCGCGGAGGTCTACCGGCTTAAACTCTCGAACCCGAGGCTCTATCGAGCCTTCCTCCGCCTCGTCCCTCCATGCTAGGGAACTCCACTCCACCCGCACCCTTGCCGCTCGCCCGGGTTCGTCCGCCTCTAGCTGCGGAAAATGCCCGGATGTTCCCCACTGCCTGCTGCAACTCCGTCGCTACAAACATATGCGGAAGAGGAGGTGCAAGGTGCAAGTGTGAGGCGGGGGAGGCGCCTACAGCAAGCCTGGAACGCGCCGAGCTGGGAAACTGTAGCACTAGCATAAAGGGATCGCACTCAGCGTCCCGGAGGGAGAGCGGGTCCGGACCGACCGCTGCGCCCCACCCTATAGTACTCTACTGCTGCGTTGATACCAACTAGGACCTTATAAGCCAGCATCGGTATCAACGCAGAAAGATTAACATGGGGACGCGCGCGGAAGTCTCTCTTACTTGTGAGCGGGAGTGAGTATTCCTCGTGGCGAGGGACTCGACGGCAGCGGTTCGTGTGGGGGGCCAGGTGGCCTCCACAGTCAGTCCATGGCAGCGCTGCGCTACCGCGGGCCAATGGTACGACACGGTACAGTGTGAAAGCCGTACGAGCTGAGCCCCCGCTGAGGAGGCCTAGAGAACCACAAGAAAACAGGCCTGTGCCGTTTACTACAGTCCTCAATCACAACCGAGGAGAAGACTTCAGTGAAGACGCACTATCACAACTAACTAGGTAAAAAGAAATACGCAGCGTGGCAGAGCAAGAATATAAAACTTGCCATACAGGACTTGGAACAAGAAAACTGAGCCTAGCAACGACAAGGTTATATCGCTTGTTGACCATTGATCTAACAAAAGAACCAACCTCACCGCTTAGACCCAAGGACTGGGGCATTACAAAAAATGCTGGAAATGATAATCAACAACAAAGCCAGACCCCACAACCACATCAGCAGACCGCCTATTAATCCGACGGCAGCACCAAACTGCAGTAGGAAATCTTCTCACCAGGGCAGGGATATTCAATCCGGCAAGTGTTGTGGTCAGACTGGAGCTAATCCTCAGGAATAGGTTTGAAACTAAAAAGCTCAAAGTCTTTTAGCCTCACCTCCATTGTGTTGCACACGTGATCCTTGGCCTGCAGGTAACAGTAGCTGCAAGACGCCTGGCATGTGAAGCATGTCACGCACCTATTTAGAAGACTTATGGCATAATAAGCGCAAGAGGTAAGAAGCAAATCAGCCCTGGACCTCGCTTCTGCTCAGTAGCGTGCAACATTTTGCTGTAAGCCATTCAAGGCCAAAGAAAATGCTGCCTCTGGGTGCATGTGCTGTGTAGCAACGCAGAGCTTTTGCTTACCCAGCGAAATGCTGGGTGCCAAAAGACGGCCTGGAAGACCACCTTGCGAAGCCTTAGACATCATCTGGGAGATATCGTAAACTTGTCAGCTCTCCAGGGCACTATCTCTCGCGCTCAGCCCTGCGCGAGCGTGTCATTGTGGTCTCTCAGAAGAGGGCTCATCGATTACAGAGTGAGAGAGTGGACTACAGGAGAACACTGAAACTCTCCAGTCGCCCTTCGCCTTCTCCATCAAAAAACGACTAATTGCCGGGCCAATCGAGCTTGGTCAGTGAGGTGACACAGTCCAGACATCGTGCACACGATCCTCTTCTCCAACAGAGCTGTCACCGTCGCCCTCCTCCTCCCGTGGGTCACTCGACGCAGTGTATATGTCCTGGAAAATATGATGTACTCCAACATTCATAACCACTGGAATGGGTTACCCCAACTGCCGTGACACTTGGCGGTCTCATAAGGAGCATTTTTACACTCAGGCATGGGCATCTTTCCATCGCTAAAGTCTCATGGCCCACTACACCACGAAGAGGACTGCACCACCGTGTACTCGTGCTGCTGCCCAAGAACGTGGGCAGGCTCTCCGTGGGAATGGGATGGTACCAAGTGCATTCAACAAACTGCTGCCGCTGCGTGCCCTCGCCCCACATAGTCTCACCTTATGGATGCTGAAGAGACGGCCCCGGGCCCATTCCGTGGCACCGATGTGGAGAGGGCTCAATCCAAGTCAAGGCTTGGCAGCCACAATCCGGCTAAGAGGAGCTCGGAGTGGATCGGGCGCAGCAATCAGCCCTCGCGCTCGTTCTGATGTATGTGCCGACTCACGCAAAGTGTCTTCAGGCCAGCTGGGCCCCTTAATAGTCCCTGGCAGGCAGCGAGAGCGTCGTCGGAGGTTCCTCTCCCAGGAGAAACATAAAGAACAATAGGAAGAATACCGCAAGAGTGAATGGGAAAAGTAGAGCGCAGCAACGCTCACAACAGAGTTCCGAAAAACATGTTAAGATACCCAACCGCATGTGGCCCGCCGGATAGCTCACGCGCAACGCAAACTACTTCTCTCGCCTGGTGACAAATCCGTATCACTTTTTCTGGGGCTGGGCTAGGCCTCCTGAGCCTGGCTTCTCCATTTTCTCTTGACCTAAAGGGCCCGTCGTCCATGCGGCCGAGGGCCGGCTGAATAAGAACCAGTATAAAACCGTGGTTGCGTTGTTAGGTCTCTGTTCGCCCCATAAACAGTCGACCTCCCTGGAGAAGCACCAGCAAGCTGTACTGTTGTGGGGTGTATTGGCACGAATGTATTAAGAAGTGTTAGGAAGTCACCGCCCTGAATAAATACTCGGTTCCTCGAGTGGCCAGGTAGTCTTAGCCCCTGGACCGAACGAGCCATCCGAGCGTGGCGAGTCCAGGGTGACTGGCTTTCCGCCCTTTTGGGAGCCTACCTCGCACGGAGAGAGATGAAGCACACATGCTCATGCAGGCGTAGCCTGCCAATTGCTTGCATGGTGATCAGGAGCACTAATCCTCCGCTTTGTCTTATGTCGAGGCCCTGACGGCAGCCTAGGAGATTCCACACAGTTTTAGCAACTGCTGGCAGGGAGAGCGAGAGAGCAAATTCTCCAGCACACCACCTAGGTCCCAGCGAGCGCACGGAATGGTCGTGTGACTACCTCACGAGACAGAGTGAGAGAGCACCAGGAGCTTCCAGCTGCCACAAGAGAGTGGACAGACCAGCGAGATACAAAGAGATTCTCTAAAGAGTCTATTGACACACACACTTGCTTTCAAATCGAGTTCTTGATGTCACGTGGATAGCATCACTAAGGGAAGAGAAAGAGCCTTCGAAGATCTCAGGAAACGGGAAGGCGTAGTGTACTTAAGAATGACACAGGATCTTTTGGGGGCGAGAATAAAAAGTTAATCCCCTTTGTTCACGTCAGTCACAGTCTCCGTTTTGCGTGCTTTCACATTCTACTAAAGTTCCAATTGCATAGTGACTCCCATCCTAGTCATCTGGTAATAAACACGAAACATGCTTGAGATCATAAAAAGAAACACACAGGAGGAAAAAGAAACCAATTTATTTATATTAAAAAACATAGTAACTAAATTCTGCTGATTGATACACACTTGCCTTATCTCTCTCGACACGAAACAAGCCCGAAAGTGAAAGGCTGCCCCCCATGGCTGGGGGCTGAAGACGCAATAGAGAGGGAGGAGGGCTGATAATCTGGATATCGTGAGAAACAGAGTGGTATGCTAGAGAGTAGAAAGGCACGACAAAGGCTTCCTTCACAGAATTAACGCAGCAGTACTCTTTTTTCTCGTATCTGTTCTTTTTTTTCTTCTGTTTTTTACTAGTATACAACGCACTCCGAGTGCTGATTTAATATCTAATGTGTGTTGGTAGTGCTTCACATTTCCTCTACCAGGAGATTGCAAGTTACACTATGAGCAGGGAGACTTATAAGTAGAATGTGAAAGCACGAGAACGGAGTACTTGCGGGTGGACTCGACGAGAAAACCAACACGAGAGTGGTGAAGCTCTCTCTCATTTTTGTTCCTCATGAACGCTAATCAAGTGTTGTCAAGCAAACACTCCTGCCGAATACCCCAAAACAAGGATACCGTAGTGGAGGAGCGGTGAGAGTAAGCGAAGAGCAATGAAATACATGAGAGGGATAAACACGCTGTGGAGGGGAGGGTTGTGGGCATAGGTGTTCTAGAAGGCTCGAGAGGAACACCTAATACTGTCTACGCCTTTCCTGATTGCGCTCCTATAGTATCCTTAAGCCACAGTCAAACACTCGATTTGAAAAGTTGTTAACTACTTGATATTTAAATAATGAATTTTATTACTGCAGTGGCGAGGAGTCTGTGAAAGTACTTTGCACCTGAGAAGCTCTGGTATTCTACTCTGGTCTGGGTGTCACCGCCATCCTGGCTCGCTGGACAGGGTTCCTGGGATTTGTCTGCCCAGCAGTTTGCTAAACTGGCTCAAGGCTCAGTGACCAGGAGAATGCCAACAATTATCTCCTGGATCAATGCAGCAAGGAGAGGGAATTAAAAAAAAAGAGGAGCATGACAATTGCTTTTTCTTCCCTAAGTAGGAGAGAAGCCAGCCGCGGCTGGCTGCAGTGATAGGCCGTGGTGATGCTGGATGGGAACGGAGGGGACCCTCAAGGCTATTCAACAGTAAAGAAAAACCGATATTGCTGGTGGGGCTTCTCCAGGGAGATATGGAACCTACAACACCAACCAGTGTTTTATACTTTCAAACAGGCCACCATCAGAGCAGCAAGAAGATCACATTAGGCCTAGCCCAGCCTCAGAAAAGTGATACTTTTAGACCCCAGGATTGCGGCGCGGTGCGGCCATTGGGTACTTATAACATTTTTCAAGCTCTGTTGTCGACTGCTCATATTTATTTCCTGTCACTGCTTGGCGGATCTGCGGTTGGGGGAAACATTTGGAGGGGCCTCACTCAATGGCACTTCGTGAGCGGACAACACACAGCCACGCCGCTAGCCCTGCGCCGGATCAGAACCTCCGACGCTCCTACTTGAGCCGACTGGCCTGGCCAAGCCGTTCCTCTCGGGGGATGAGCCTCTCTACTGATGTGCCACCAGGGCGCGCGGGCCGTCTCTTCGCTCTGATGGCTTCTGGCGGGGCACGCCAGCGGCCAGCGAGAGTGTTGTTATTTACATCCCGTCCCAGACTATCCACAGTTTCTGGGGCACGCAGCCAGACACGTGGTGGCAGCTTCCTCGTTGATGGACTGGTTGAGCTACGAGAGGAGCCAAGGTAACAGCAGATGTGTGACACCAACAAACTGCGATGGAAATTTTGGAGGGTACGTCATCAATTCCTCAGATGCACTGCGTTCTGACGTGACCCAGGGCGCGGCAGGAGAGGCGACGGTGCAGCTCGTGTGAGAAAGAGGACAATTGCAGAGGCTTGGACCTTGTATCAGACCAGCATTGCGCCAAGTTAAGTCCCGTTTTTTTTGAATGGAGAGAGGCGACTGAAGTCCAAGTTTCCAGAGTCTTAATTCTGTAAATCTGATGACCTGAGGAGACCAACAATGAAACGGGCAGGAGCTGAGCGGCACAAAACATCCCTGGAGGAGTTGGACAAGGTAGAATGCCACCAGAATGATTCTTGAAATGGTCTGCCGGCGTCTTTGGGTGAGAACTCCAGGGTAAAGCAAAGCTGGCTGCGTTGCACACAGAAGCACATGAAGAGGCACATTCTTGGCCTTGATATGCTTCAGCAAAATGTTGCACGCTACAACAGAGAGAAAAAAAACAGCGGATGCAGGCGAGGTCCAGAGGCCATTGGCTTCTACCTTGGCTTTATGCCATTCTTCCTAATGCGTGAACTGCTTCACTCGCCTTGCCATGTTCTGCAGGCCAAGATCACGGTGTGCACCATGGAGGCAAAAGAGCTTGGCAGTTTCAACCCTTATTCCTGATTAAAGCTTCCAGGTGGGGAAACCACAACCACTTTGCCGGTGAAATCCCGGCCCTGGAGAATTCCATGGCAGTGTGCTGCCGTCTATCTCTGCGGGGGGTTGGCCTTTGTTGGATTATCATCCACAGTAAATGCCAGTTGGGTATCGTAGGTGGTTTCTTTTTGTTGATATGGTCAACAAAAAACACTTGTCCGTTTCCTAATCAAGTTTCTTGTTCCCATCCGTATGGCAAATTCCTGCCACTCGATTTTTTTTTCCAGTTTTTTGGATGTTCCCACCTGAGTCTTCTCCTCGTGTGGATTGGCCTGTAGTAAAACCCAAGCGTCCTTGGTGTTTCTCTCCTCACCAGCCCGGGGGCAGCTTCGTCCCTCACTGTCCGGTCGTCCAGGCCCGCGTAGACGCAGCGCTGCAGGTCTGACTGTGGAGGCACCTGGCCCCGCACTCAAAGCCGCTGCGGGTCCCCTCGCCCAAGGAACTCACTTCAACCGCTCCAATAAGAGCCCGCGCGCGTTCCCCCATGTAATCTGCTTGAATACCACTGCTTAAGCAGTGGTATCAAACGGCTGTAAGTGCTGCAAGAGTACATGAGGGGGCGCGCCGCGCGGCCCGCTCCTCGGGCGGAGCGTCCCTTGGGCTGCAACGCATAGCTCCAGCCTCCGCGTGCTCCTCCTCGTCCCCGCCCCGCCTCACAGCCCTTAAGGCGCTAACTCACGCATTTGGCGCCCGTGCAGCAGGGCAGTTGGAACATCCGGGCATTTCCGCAGCTGAGGCGGCGACCCGGGCGGCGGCGGCGGTGGAGGAGCGTCCCCAATGGTGGCAAGGGGACGACGAGGCGGGAGGGAAAGTGCAAAGCCGGCGACGGAGTTAAGCCGGACCGTCTCCCGCGGGGCCGGGTTTCCGGAGGGAGGCACAGAGGGAACGCTCCTTCGCGGTCCGGAGGAGGCCGGGCGCGGGGCTTCTGTCCGCCCCTTCGCGCATTCTGTACAGCCCGGGCTATCCGGAGATATGCATCTGCATAATCAAGGGTCTCAGGGGCTTGCACCCTGAGACACTGCTTACTCCGTGGGCAGCGTCGGGGATGTCCCTTGCACGGCATTTGGATCAGGCCATGTGATATGTTATTGGGTTGGACAAATGACTAAATGAATGTGTACTATGATCATTATCCTGGTGCCTAAGACCAGGAAACATCCAAGTCACTGTGTGGAGTGTTCTAGTCCAACAAGGATTAGAATTGCAGCTTCATATGGTAATGTCCTTTGTAATATTTGAGAGCCCTTGGGCATATAAGATTTCTATATAATAGAAATTGTCACTCAAGTGCCATGAGGATTTGGGCAGTTTTTTGAGTCTGTGACGTACCAACTATAGCATAGGGATCCTCAAGATAATAGATTGTTGACAGCACTGATGTCCATTCAGTTTGTGGGCTCCTCCAGAGATGATATTTCTGGTAAGAGAGGAGGAAGAAATTGACGTAATAACAATCTCCCTACTGTTTTAAAATGATTTGGAAGTGCGTCTGGCAGTGCAACAACCTCAGTATCTATACATTGATGGAATGGTCCCTGATGGTGATATTTTTGCTAACATGGCTGGAAAGATGATTGTCTTTTGGAAAGTGGTGGTATCCTATGGACTGGTTGGAAAGTCTTCAATTAGTACCTCAAGTGATCATCATCCCGAAGTGAAAAGGAGGACAGGGAATCCCTTACTCATTTTCCTTTTGTGTTTACTTGGCACATCCCGAGCTGGTACAGGTTTTCATGCGTAAACTAGCAAGTATAGCCGCAGGAGGGTTTCTCTGTCTGTTAGTGTTTATTTAACTTCGAGGTCATGATGGGTGTTGCCGGCTCTGGGCAGAGAACCTTTATTACCAGAAGAAACTGTCTTTTGGCGTGAGCAGATTTGTGAGACTAACCACTCAGCATTGCCAGCACTTTCTTTCATGCTGGAAGACACAAAGACGAATACGCATGCTCATGAGACAATACACCATTTGAAAATTAAGGAAAGGACAGAGGAGTGTCATATCTGTTCTTTGTAAACTCACAGCGAATTAATGCCCGACAGACAGCAATGCAGAAGTTAAAGACACATTTCCCACCAGCAAATGACTGCTCGGTATTGCGGAGCGCATCAACCCTGCGACGATATCCAAATGTCTTGGTTGGCACTTGCATTTAATGTTTGATAGAGGGTGATGGAATGGGGCTTTTGGTAGTTCATCTGTGGTCTAAACAACAGGAAATTTCATTTTACGCGTCATCTAACGAATATTTGTGCATAGTTACGAAGAAGCGGAAAATTGACAAGTAGATCATAATGATGATCGGCGTGTAGAAATAGGAACTTCCGGGAAGAGCGGGGTTATATTACAATATGAATTAGACTCTGATTAATCCCTGGATAGAGAATCTAGGCGGTAAGGATCAGTTACGGGAAACATGAAGTTGGGGAGGAGAGAGATAAGAAGATCCTAGAACTTATTCACGACTCTAGTGTACCAATGCCACTGCTACCGGTTCTGCTTTGAATCGGAAGATTGAAACGCTGCTAACTGATATGGAATAAGAATCCTGATATGCTTTTTACAATACATCCTGTAGATGGTACCTTTCTAGTGTGCATGTAAGTTTGGAGATAAAATCCTGGAATATTTAGACAATCCAGTATAATTTATTGATGAATGTTATTACATTTCTTAAAACAATAAAGAAATAAATG 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@rCer/2209/25_1532_CCS 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@rCer/2210/25_2228_CCS ATGGGGAGGTTCGCGAGCTGTTGGAGGTCTCTGCTGTTCCTCCTGACATCAACGAAAACCATGTCATCAGAATCGAGCAAAAAAACGGAAGCCCAAAGTCATCCGAAGTGATGGAGCCCAGCTGAAGGAAGCGGATCGATCTGACACTGAGCAGGAAGTAAATACTACAGTGAGGAGCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGATTATACAAGTACACCTGCCAGGAGCTACGAGGCTGATGGCTGAGATCCAGACCTGAGAGCAGGGGTGGCAAGGATGTGCAATCGAATTGAAGAACGGAGGATTCAGAGCTGTGCATTCATGACTCTAAGAAGCTTAACCGATTTAGCCACATTCAGGTTGAAGAAAGAAGAGATCAGACCACGAGGCTAAGCAAAAGTAGATGCTATCACTTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCGAAGCACGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTATAAGGAGGCTCCACCAGATATCAGCAAGCCGAGTCACCATGGGAGACCCTCACCAGCAAACATGGCACGTCTAGACTGGGAGCTGGAGCAGCGGAAAGGCTGCAGGAAGTATCGAGAGTGCTATCCAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCGGTGCAGGAGTACCTTTTATGCCATTCGACCAGGCTCACAAGCAGTTATGAGACAGCCAGGCACTGCCCCCCTGCTATGTCCTCTTTGTCAGGCACGCATATGGGCAGGCCTGTGCTCATATGAAATCCTCCCAGCCCCTAGACAGGATAAAGACTTATCTGTGCAATCGAAGCAGTGTGGATGAAGCCAAGGCTCTTTCAAGCCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCGGATGCTGAGGAGGAGCAGAACCACGAAACGCCGGAGACCCACGCTGGGGTTCAGTTGGACGACAAACGCAAAGAGATGCTGAAGAGGACCCACTGTCCGTCATGCTCGACCTGAAGTGCAAAGATGACAGCGTTGCTTCACTGACTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAGCCAAATGACAACCGCACAGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGATCATGGAAAGAAAACTCCGAATCCAGCAATCAGTATCAGTTTGATAAAGTTGCATCCTGACTTTGACGACTATGTACTTGAGCTAGGTCACCCTACTTGTGGGTACAGAAGCTTGGTGGCCTCACTTCCCCAAAGAGCAGCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGCATTGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGTGACAGTTGCCATGAGGATTACATGGAGCTGCATTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCACTCATCGAAAGGGCACAGCCAAACTGCAGGCCGCTGTGGTGTTGAATCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAATGATGACAACATTCGGCCATGGAGGGTGAAGTCAATGTGTGCTACAAGGAGCTGTGTGCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCATGACGACAGTGTGGAGGGGCCCAAGAATTTCCCCAGGAGAAGATGTTCTGCGGCTCTTCAGGGGTCCAGCAGGATGAAGCCATTTAAATACAACCATCTCAGGGTTCTTCAGCCATCGCGACCTCTCGCCCAGCTGTGTTTCCCCAAGGCCTCACCCTGAGTCCTGGGCTTCTGCTTTCTGCTGTGGCCCACATGTGACTCTTGATATTCTCTAAAGACACCAGCCGATTAAAAAGCGTCACCT 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@rCer/2212/25_1683_CCS ATGGGAGAGTGCTGCAGCCGCTGCCGCCGATTCGGGATCTCATTGCCGCGTGTCCCGGACGACCGCCTGACGTGCATTCCCGATTCCTTTTGGTTCCAAGTCCAATATGGCAACTCTCAAGGATCAGCTGATTCATAATCTTCTAAAGAAGAACAGACTCCCCAGAATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTAATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGAGAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGGAAAGACTATAGTGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAACAAGAGGGAGAAAGCCGTCTTAATTTGGTCAGCGTAACGTGAACATCTTTAAATTCATCGTTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTGGATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGAAGTGGTTGCAATCTGGATTCAGCCAGATTCCGTTACCTGATGGGGGAAAGACTGGGAGTTCACCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTATGGAGTGGAATGAATGTTGCTGGTGTCTCCCTGAAGACTCTGCACCCAGATTTAGGGACTGATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAGGTGATCAAACTCAAAGGCTACACATCCTGGGCCATTGGACTCTCTGTAGCAGATTTGGCAGAGAGTATAATGAAGAATCTTAGGCGAGTGCACCCAGTTTCCACCATGATTAAGGGTCTCTATGGAATAAAGGATGATGTCTTCCTCAGTGTTCCTTGCATTTTGGGACAGATGGAATCTCAGACCTTGTGAAGGTGACTCTGACTCCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCAGATACACTTTGGGGGATCCAAAAAGAGCTGCAATTTTAAAGTCTTCTGATGTCATAGCATTTCACTGTCTAGGCTACAACAGGATTCTAGTTGGAGGTTGTACATGTTGTCCTTTTTATCTGATCTGTGATTAAAACAGTAATATTTTAAGATGGACTGGGAAAAGCATTAACTCCTGAAGTTAGAAATAGGAATGGTTTGTGAAATCCACAGCTGTATCCTGATGCTAGATGGTATTAATCTTGTGTAGTCCTAAACTGGTTAGTGTGAAATAGTTCTGACGCACCACTGCCAATTCTGTACATGCTGCATTTGCCCTTGAGCCAGGTGGATGTTTACTGTGTGTTTTATAATTTCCTGGCTCCTTCACTGAACATGCCTAGTCCAACATTTTTTCCCAGTCAGTCACATCCTGGGATCCAGTGTATAAATCCAATATCGTATGTCTTGTGCATAATTGTTCCAAAGGAGCTTATTTTGTGAACTATATATATCAGTAGTGTACATTACCACATAACATAAAAAGATCTACATATAAACAATACAACCAACTATCCAAGTGTTATACCAACTAAAAACCCCAATAAACCTTGAAC + FB+@<>79=E<9?C>?B=ECBCF3E@@BA:CA5EE%BEED>D>1BB:ABE<89><3;9B?@5;E0C8<,EFA=E;AE9BBECGD@=AFEC/@AB?@@2=/<>@5A+$4B:>EB?@E?=0CC<>@';A@?E3)BCD?@8?;B2@?D:D;CAC?E3B==C@DCDFFBCA>AABF4B?AF-DA<6=7DF@C99<'C35ACG@==:E?DBC6?3;;EFBFB@GCEGCA@BFFE:>A)E<=:B@A958;;;5;8=CFFF=(B>?C3C4GDBCDD:CC>CA;B?;EC>@+EB>9?GEDE@FCBGA91:9>63EFBD;AEE9A9C=B?8D>$B;AFCBEFGFBCGAEEFEGE:BD2>ABABC:E+A:;D@>:E@:5BE??;?7<5<9>?A;BB>->A==CC?@?C7:A:;8A>B7=:>8?<&;9A?<>@=??C<2CBB=@CAC@=B0C>=A89@876@-7;?:/B>9@>A&=>><.<>4)?96=3=<96@A?B<:=BA;A@;6647%7984B?5:262/70;AC<79<9<4A=<<=:7;8,.8>/89:7?@A?;A6AB98>)=:=>@C/ABB>ACCCA>>;893?;;<8A>><<5?>@<;<@@@?8/8>?=7;?A?,?@3A9B><8:=A?@34BA::;<8:6=<054?C:?<49:=6;>@;@5)A;@9?B@>=9?8?==B<71A@@.@BA8@<$46?0>92>9==BCC@C??88A?@?A>A;C?8<>=7>9AB9@>A<>186=@B79?:98;8;=87?=@@=;83875%620>@==;7;A/<<<4/59B?@C;@7;9@38@@:73A<03809/0?>2;:3A??CA=B=85?5>AA5@>4+80AAA@?;-:=.7B;=6848@1AC;=7BA??==.=>A5>@?A=>?A86B>7AA;A6?A6A;;?B=4A=:>2;;==>;8??BA=.?=61;@=5?6?>@>523<5=7AA?=<9;-517=@BC?;7;>;;<8A8@??8B<6<>C9@@<6758:@C=B>?@8?5>>:A?A@B8>?B;9?:CC=&7<;BB=:=CA/A=;A=@9=CCAC?@?=78(79::A;A';;;?=5<7=;A=BB?7=>/@A>:79C=>==4>8A7>0?A=>@7?7@AB>>B;9<=68=@B6CC@:=>>;?<96=-99<@<8>?=?=><+>23>7A;::=:',>;C27=>B:@@;@@9?.895?A?149=6,59:9?>A6)703@<0==9A2<77??AA?B5>?97/>5<4><<=B0651>.;-<85?C3=;3?C;:<59<5<9=6?0<;?>:A4?0?B.@>-59@B8D= @rCer/2214/25_1580_CCS ATGGGGGGGCCGGAGTGGTGCGGGCGGCGCGAAGCGGCGATTCCCACGTGTTGGCCTTCTCACGCTAGCCCACTTTGGTCCTCCTTGAGGTCCCGGGCCTGTGGGCCCGCTTCCTGCCAAGATGCCGAAGGTCAAGTCGGGGGCCATTGGCCGCCGCCGCGGGCGGCAGGAGCAGCGCCGGGAGCTGAAGAGCGCTGGAGGACTCATGTTCAATACGGGAATTGGGCAGCACATTTTGAAAAATCCTCTCATTATTAACAGCATTATCGATAAGGCTGCCTTAAGACCAACTGATGTAGTGCTAGAAGTTGGACCTGGAACTGGCAACATGACTGTAAAGTTGTTAGAAAAGGCAAAAAAGGTTGTTGCTTGTGAACTTGACCCAAGGCTGGTAGCTGAACTTCACAAAAGAGTTCAGGGCACGCCTGTGGCCAGCAAACTTCAAGTACTAGTGGGTGATGTGTTGAAAACAGATTTGCCATTCTTTGATACTTGTGTGGCAAATTTGCCTTATCAGATCTCATCGCCTTTTGTCTTCAAACTGTTGCTACATCGACCTTTTTTCAGATGTGCTATACTTATGTTTCAAAGAGAATTTGCCCTCCGACTGGTTGCAAAACCCGGAGATAAGTTATACTGCAGACTCTCAATTAATACACAGCTGTTGGCACGTGTGGACCATCTAATGAAAGTTGGAAAGAATAACTTCAGACCACCGCCCAAGGTGGAATCCAGTGTTGTAAGGATAGAACCTAAGAATCCACCACCACCCATCAATTTTCAGGAATGGGATGGTCTAGTAAGGATAACCTTTGTTAGGAAAAACAAGACACTCTCTGCTGCATTTAAATCAAGTGCAGTGCAACAACTCTTGGAAAAAAAACTACAGAATTCACTGTTCAGTCCATAATATTATAATACCAGAAGATTTCAGCATAGCAGATAAAATACAGCAAATCCTAACCAGCACAGGTTTTAGTGACAAACGGGCCCGTTCCATGGACATAGATGACTTCATCAGATTGCTACATGGATTCAACGCAGAAGGTATTCATTTTTCCTAGGTGTTTGGAACACAGAATTTTTCAAGGTCAAGAAAAGAAATGAAGTTTGTATTTTTTGTATTTGAGAAGATAATGCTTTTGCTTTAGAGACATAATTTACTTGACTGTTTTTGGTTCGATACTACTACTGTTGTCACCATTTATGATTCTGAATTTTTAAGTTGGAAAGTTCTAAGTATCCAAGTTTTTAATGTATAGAGCTGGTCCAATCTATTCACAATAATCTTCAAGTTCAGGAGCCGCAGAGACGCACAACTTTACACTTAAACTTATTATTTCTAACAGTTTATTGTATAAAGATGTTACTCTTCTATTTACTGTTATATACTGTGAGGCCTTCTTTAGGCCTTTAGCTCTGTTCCTCCAGTAGTAAAAACAGTTAAAATATGCTTCACTAGTCACACATTCCCCATACCATTTCATGTTATTCACATTCCCTGTACCATTTCTTGTTATTCACATGTACAGTAAAAATCATTGTTTTTTTAAAG + HC3KKKIJKEIDG<=4,B9ID>KHCJKKHDE8J?IIH8A;FK=CDJDEJD2HKKJKAKKIJFKKKFJHD?KIKFKKJKBHKKKFGKKJEFCAKKHKKKKKJK?KKGKKIK0KJKKKKK5B:KJE:EGAIEJH:7GJKKHDK=JKKKJKKIGIKKKKKK2BJHBKJGKK:JDIK@EGFI-JI1KKKKBKK:KKIJJKGCKJKKJKKJK-KFKJ:8IE)KK:FK@H>GKJHKJKEJJGKKDKIJK)CKKKGKAKK=KJJKKIKKKFCKKKKKKKKFKKKKKKKK>KKFJ@=E??DCK;KK6KKK8KKFKKKK@KKKKKKC?KJKJKIKEKKI1KKKGKJKKKJJKKKK1DA1?BIKJKKHJJJKKHKIKAKEHKIIKJKII8KJKKKKKKJKHKKKKKAKKKKKKHKKKIJ=K6KKKEKJKKKJKKKKDJHHEDJJKKAKGKDDKGHHKKKKKK7HKECKIBEIIG3KKKICKJ@K?@KK>JGKKKKKAKKHDKIJGJBHKIE@KH9KKDKK0GKEHKI@ICJHJBKKKKKKDKI?KKKGKKK-GAB:KKKJJHDEKK7KKKK8IHJ;5:?9C7CFIKD?HKIFCHHEAHJFJKJHKEH0A;*HKJKKK@KKKJKJKCK>C/HJJHIAKH8KKJHJH5G7JK>9D;?=A6FKJI@KJKK9JJIFJA=JJCIKJIEKHKIJJGC?BJE*BKIKHA6@<8B.>JJK/HJJD@J1IABJKJKKJK-KJIKIIIEJ5K>GKBK>KG4HC$BIE>@A>CK1C>EDHGBB6CFDECHJJJCHIC?GEDKKKEJIFJBGGIIJJH5KD>KEJID@KCKJ@EBGBJ??JFG9JI6D@BIGIJDJA?EE@II%DGC;>7>BJA$;DKBE.1KKK @rCer/2216/25_1507_CCS ATGGGGGCGCCTTCCCGGGTCAGTGCGCTGAGGCCTCCGTATCGCCGCTGCCGCCTGCGCTTAGGCTGCCGCTGCCGCCGCCGCCCGCGCCTAGCCTGCCGCGGCACGCCCGGCTGCACGCTTTGCTTGGCCTCGCCATGCCGGTGGACCTCAGCAAGTGGTCCGGGCCCTTGAGCCTGCAAGAAGTGGACGAGCAGCCGCAGCACCCGCTGCATGTCACCTACGCCGGGGCGGCGTTGGACGAGCTGGGCAAAGTGCTGACGCCCACTCAGGTTAAGAATAGACCCACCAGCATTTCGTGGGATGGTCTTGATTCAGGGAAGCTCTACACCTTGGTCCTGACAGACCCGGATGCTCCCAGCAGGAAGGATCCCAAATACAGGGAATGGCATCATTTCCTGGTGGTCAACATGAAGGGCAATGACATCAGCAGTGGCACAGTCCTCTCCGATTATGTGGGCTCAGGGCCTCCCAAGGGCACAGGCCTCCACCGCTACGTCTGGCTGGTTTACGAGCAGGCCAGGCCGCTAAAGTGTGACGAGCCCATCCTCAGCAACCGATCTGGAGACCACCGTGGCAAATTCAAGGTGTCGTCCTTCCGTAAAAAGTACGAGCTCGGGGCCCCGGTGGCCGGCGCGTGTTACCAGGCCGAGTGGGACGACTATGTGCCCAAACTGTACGAGCAGCTGTCTGGGAAGTAGGGGGTTAGCTTGGGGATCTGAAGTGTCCTGGAGGCCCCAAGCCCTGTTCCCTAGTTCAGTGTTGCATGTATAATAGATTTCTCCTCTTCCTGCCCCCCTTGGCACAGACGACACCTGGCCAGTCAGATGGTGTTTGAGGGTGGCTTTTCCTGCTGCCTGACCTTTCTAATTTTACTCACTCACTCTGATTTATGTTTTGATCAAATTTGAACTTCGTTTTGGGGGATATGTTGGTACTGTGATGGGGTCATCAAATTGTTCATCTGAAAATAGCAACCCAGAATGTAAAAAAGAAAAAATCGGGGAGGTGGGGGAGAAAGACCAGTTCTACAGTGACAGAGCAAAGCGTCAAATAATCTTTAAGGGAGGTTAAAAAAAAAAAAAAAAAAGATTGGTTGCCTCTGCCTTTGTGAACCTGAGTCCAGAATGGTACACAATGTGTTTTTATGGTGATGTTGCTCACCTAGACAAGCAGAGGCTGGCATTGAGGCTGACCCCCAACACGGTACATCTCAGATGCCTCGACAGGCATCAGCATGTCGCTGTGTCCCCTTTAAAGAGCAGTCCTGGAAGAGGCAGGAGGCAGAGTAGCTTTGCTGCCGTTGGGACGTGGCCATGGAGACCAGCAGCAGCGCTCCCTGACAGCTTAGGAGGAATCCTTACATCTTTGTCTGTTAAATTGATCGTTCTCATGGGGGTCAGAAAAGCTGGTCTGGAATCGCTGAATGTTGCATTAATTGTGCTGTTTGCTTATAGTTGAATAAAAATAGAAACCTGAATG + JK.KKKKKKIKKKJKK-JJKKKKKKKKKJKJKKKKHJKKKKKJKKKK@KKKDKKKKKKKJKKKKKGIIKKJKBKKKGKKKKKKK3KKJKIKKKKKKKIKKKKKKCKKKKKKIKJKKKKKKKKK*KKKKKKKK;KKKKKJKK@KKKJKC-KK>KKJKKKJKI#KKGKKHKKKKKKJKJKGK:K8JKKJKKKKKKKKKKKJKKKKJKKJKKKKKKKKKKKJKKKKK;KGJKKKFKKFKKBKKBKKKKKKKKJKKKJKKKHKKJKKKJJKKKKGHIKGDKGKKKKIKIKHKIJKJKKJJKKKKHKJDIJKKKDKKGKJKKKGKIBKHKKKKKKKKKKKKJGKKKJJKKFKKJKK?KJKIKJKKKKKJKKKKKJIKKJJJIBGCKKDKKKKKKKKKK9KKKKKKKKJKJKJK,KKKKKJK:KBKDJKKKKKKAIKKJKKKKKKKKKKKJKKKAKKKKJKKK>KK/KKKKKIKKKKIKKKJDKCKKKAKK5KKK8JJKKKHKKKKKKKKIKKJKKJKKKJEKKJKKKKKKJJKKKK7KKKKKKBK7KKDKKKKKK:HHI?KKKKJKKKKGKKKKJKKKK;JKKKIJ?KKKKKKK8KKKKGKKBKKKKKKDKKKCFKJKKKKKKKJKIKKKKKKKKKKKKKKKKFKEKCKGKIKKKK>KJKAJCK*HKKKKKKKKIJKKKKKKKKKKKK?KKKKJKKK3KIKKKKKHKKKKKKHKKKKKKKKIKKIJKKJKKKIK9KKKKJFIKKJKKK:KKKAGKKKKKKKKKKKIKKKJKKKGKKKGKKIKKJFKKJKKIKIKKJKJ7KKIKCJ6KKKKIKKJKKHHK>KKCJKKKKKKKKKKKKBKKKKKJKKKKKKKKKGKKGKIIKJKKKKKKKKKKKKKKKKKKKGK=KK@HGKJIIKJE?JJIGGFGBJJCGJH@GEKK6H@F5KFKKGFJEHJ;I;?IJKIKHG6@J?HJKIJFGIIJHJJHCIKHHGFJ;D7GIEHGKHJBJFKKGDHKCH@JICGGIEFEHG+JHEGIIJGHEAHKIHJJ=?FIHDJJJGJJ?KIC8=IEJI89DKIDBGJCFA;KIJ=EIHDEIIJKGGIKJKFKEE6KEI8I@EJCFI:H&HFFFFKCIHF=II:JCGI;BDJHKKA@E@HJG*HD?DHKEJDFHICFJBEHBEJKKAIGJJKCJH@GADIJIJIKKK:ECCIHGKBKJJKGKJHI8HG@EDDAA>KAFHF=DKGJ<>EDJFKJ.JHAKEHHFCFDEBGDG?DHBIBF8CAIJ>GBJFHEBJG@IA?05=8I?EIGHIIHIHGDHGE=B.IF6IGFIIIIGEEHGA@CA3HIGHIJHAAFHAF:AA4EDHF:-FD@HFCC=EHII:DEGF7GHFCF88GI@CE>:>A??GF7=GDF?FH?6>BGHFJJFFIJBGH>?=D7DE>?AGHC>>EFEJGH>G>JHFH=J=HGGFGHE;GIID?GH6C;H@GFH*FG9CEDD7JDA@F7H?IFFHDI=HI9FJDGGIGA<7DADICHFFC?@DCH@GHGFHC@EADIJIJ?AA:G5BHGEEIIGCHEHHJCIEHG6DBII?E??AJH6IFFH=FHCGDHGGEGG=DABIAD;HDF?E;F?F:IB==D-IICHBG?D8=CCDCGEA;ACGJJCGEH@HJAH?EGB=9GIB?FHF@@F6FEAE@E;BE=C?IAGIFIDEDD)BIEIDGDHAGFA=C@IDAC?A;HEDB=@E?GFCIIHII2HI?=GDFC;BDGD?BIGGEHI?HI>G?DBGCAE;EGHIHEECDGHEDHIAGF93JFBGG7CE>CD3IEDGB=JEH=GEC?B7:ADFFGCFHHJ>GJFE8GDA90BBG<6-;:7AFH?HDGB?89HGA9HG>EHG@GIA?<.BCFCC?G>:FBAFJ:8@DC>9JDGB;CDHEIDEDDFC;?:EIIE@?CC9=C>@D0DCCD9CECAEB?@JJ?JGHIBGGD7EHE;>$>>FCF?GB=DB6CC>EICBFGDDDDEG2E?BDIHFEFJ>DDGCED<:ACB7FDE8EBDFD@GFCBAB=3A;8B3;::DE=4B7=;;8@AEG@DD9CG;D@E?>6?9-?CBBEBB@3?BFGD8D6A?@9=$;B@F:D<:<=@>ECE3B@4@<0EDABEDEB:@B;5DCBCEDC7B>BA9@D@ @rCer/2218/25_2421_CCS ATGGGGCTCGTCCCCGCCGCGGCCGCGCCGCCTGCAGCAGCACCAGCTGCTCCTCCCCGGCGGCCGCCCCCCGCGGGTCCTCCCTGGCTGCGGAGAGACGGAGGTAGAGGGAGGACACAGAGCCGCGCCGCCCGCACCGGAGACCTTCTCCTCGCCCCGCCGGTTCCTCACCCTCGGGGAGCAACATGGATAGTCTCAGTGATACCTTGAAGAAGCTGAAGATAACAGCTGTTGACAGGACTGAGGATAGTTTAGAAGGATGTTTGGATTGTCTGCTTCAAGCCCTGGCTCAAAATAATACAGAAACAAGTGAAAAAATCCAGGCAAGTGGAATACTTCAGCTGTTTGCAAGTCTGTTGACTCCACAGTCTTCCTGCAAAGCCAAAGTAGCTAACATCATAGCAGAAGTAGCCAAAAATGAGTTTATGCGAATTCCATGTGTGGATGCTGGATTGATTTCACCACTGGTGCAGCTGCTAAATAGCAAAGACCAGGAAGTGCTGCTTCAAACAGGCAGGGCTCTAGGAAACATGTGTTACGATAGCCATTCACTTCAAGCTCAGCTTATCAATATGGGTGTTATTCCTACCTTAGTGAAATTACTGGGCATCCACTGCCAAAATGCAGCTCTTACAGAAATGTGTCTTGTTGCATTTGGTAATTTAGCAGAACTTGAGTCAAGTAAAGAACAGTTTGCCAGTACAAACATTGCTGAAGAGCTAGTAAAACTCTTCAAGAAACAGATAGAACATGATAAGAGAGAAATGATTTTTGAAGTTCTTGCTCCATTGGCAGAAAATGATGCTATTAAACTACAGCTGGTTGAAGCAGGCCTGGTAGAGTGTCTACTAGAGATTGTTCAGCAAAAAGTGGATAGTGACAAAGAAGATGATATTACTGAGCTCAAAACTGGTTCAGATCTCATGGTTTTATTACTTCTTGGAGATGAATCCATGCAGAAGTTATTTGAAGGAGGAAAAGGCAGTGTATTTCAAAGGGTACTTTCTTGGATTCCATCAAATAACCACCAGCTACAGCTTGCTGGAGCATTGGCAATTGCAAATTTTGCCAGAAATGATGGAAATTGTATTCATATGGTAGACAATGGGATTGTAGAAAAACTTATGGATTTACTGGACAGACATGTAGAAGATGGAAATGTAACAGTACAGCATGCAGCACTAAGTGCCCTCAGAAACCTGGCCATTCCAGTTATAAATAAAGCAAAGATGTTATCAGCTGGGGTCACAGAGACAGTTTTAAAATTTCTTAAATCTGAAATGCCCCCTGTTCAGTTCAAACTTCTGGGAACATTAAGATGTTAATAGATGCACAAGCAGAAGCTGCTGAACAACTGGGAAAGAATGTTAAGTTAGTGGAGCGTTTGGTGGAATGGTGTGAAGCCAAAGATCATGCTGGTGTGATGGGGGAGTCAAACAGACTGCTGTCTGCCCTTATACGACACAGTAAATCAAAAGATGTAATTAAAACCATTGTGCAGAGTGGTGGCATCAAGCATTTAGTTACCATGGCAACTAGTGAACATGTAATAATGCAGAATGAAGCCTTGTTGCTTTGGCATTAATAGCAGCTTTAGAATTGGGCACTGCTGAGAAAGATCTAGAAAGTGCTAAACTTGTACAGATTTTACATAGACTGCTAGCAGATGAGAGAAGTGCTCCTGAAATCAAATATAATTCCATGGTCCTGATATGTGCTCTTATGGGATCTGAATCTCTACACAAGGAAGTACAGGATTTGCTTTTCTAGATGTCGTATCCAAACTTCGCAGTCATGAGAACAAAAGTGTTGCCCAGCAGGCCTCTCTCACAGAGCAGAGACTTACTGTGGAAAGCTGAGAACTGCCCGATACACGGCATCATCCCATCTCTAATTTCCCTCTGTCCTCCATCTAGCGGCTTCTTCCGCTTCATTCTCTACCATACCACTTGTGCATGCATGTAATGTTCTAATACCAGTTGAAGAACTGCTGTAGGTACCTCCCTAATAAGATTTCTAAACCCATAGTTAGTGTGATCATGACTTTGTCAAAGGCAAGTCTCCACCCATAACTGTTCTCTTGTATCCCTGTTGCTTGAGCTACATTAAGTAGAATGTGCATGTTGTAGTCCTATGATGATGTAAACTTGGTACTACATAATGACTTGCTCCACACATGCAGTAAACTACATAATGATGTACTGGTAAACTAGAAACAAAGAATGCAGCAGGATCTGTCTAGCATATTAAAGATGAAACTGAATTGGAAAAATAGCTCCATTTTTTGGTGCTTGGGAAGCACAGTGACCAAAAAAGCTGTATGGCTGCTTATTCATTAGCCTTTCCTACTAATGTCAAACCCATGGTACCTAGAGTTAAATAAAATTCCAATGCCC 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@rCer/2224/1608_57_CCS ATGGGGGAGGATGTCGGTGAATTATGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGCCTCCCTGAGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGTGTGGGAGCTGGCAAGGCTGGTCTGGCAGTCTTCCCATGTGGTGTTCCATACGGGTGCCGGCATCAGCACTGCCTCTGGCATTCCCGACTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGCCTGGCCCCCAAGTTCGACACCACCTTTGAGAGCGCACGGCCCACGCAGACCCACATGGCGCTGGTGCAGCTGGAACGCGTGGGCCTCCTTCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCATGTGCGCTCAGGCTTCCCTAGGACAAATTGGCAGAGCTTCATGGGAACATGTTCGTGGAAGAATGTGCCAAGTGTAAGACGCAGTATGTCCGGGACACAGTCGTGGGCACCATGGCCTGAAGGCCACGGGCCGGCTCTGCACCGTGGCTAAGGCAAGGGGCTGCGGGCCTGCAGGGGGAGCTGAGGGACACCATCCTAGACTGGGAGACTCCCTGCCGACCGGACCTGGCACTCGCCGATGAGGCCAGCAGGAACGCCGACCTGTCCATCACGCTGGGAACATCACTGCAGATCCGACCCAGTGGGAACCTGCCGCTGGCTACCAAGCGCCGGGGGGCCGCCTGGTCATCGTCAACCTGCAGCCCACCAAGCACGACCGCCATGCTGACCTCCGCATCCACGGCTACGTCGACGAGGTCATGACCCGCTCATGAAGCACCTGGGCTGGAGATCCCCGCCTGGGACGGCCCCCACGTGCTGGAGAGGGCGCTGCCACCCCTGCCCCGCCCGCCTACCCCAAGCTGGAGCCCAAGGAGGAATCACCCACCCGGATCAACGGCTCTATCCCTGCCGGCCCCAAGCAGAGCCCTGCGCCCAGCACAACGGCTCAGAGCCCGCCAGCCCCAAACGGGAGCGGCCCACCAGCCCTGCCCCAACAGACCCCCAAAAGGGTGAAGGCGAGGCGGTCCCAGCTGACCAGGGTGCTTGGGGAGGGTGGGGCTTTTGTAGCAACTGTGGATTCTTTTCCTCTCGTGGTCTCACTTTGTTACTTGTTTCTGTCCCCGGAGCCTCAGGGCTCTGAGAGCTGTGCTGCAGGCCAGGGTTGCACCGGACCTCCATGGTCTCTCCTGGGCTCTAGGGCCTTTGGTGGGTTTGGAGAAGAAGCCACACCCCAGAGCTAACAGCTGAGCCCCTGCCACACCCATCCTCTGACTTGGAGTGTTGTCCAGAGGTGCGGCTGGGCCCTCCCTGGTCTCCAGCTTAAACAGGAGTGAACTCCCTCTGCCCCAGGCCTCCCCACTGGCCCTACACCCACCCTACCCTCTCCATGGACCCTGCAGGAGGGGAGACCCACCTCGAAGTGGGGGACACAGTAGAGGCTTTGCACTGCCTTTGGGGCTGGAGGGAGACGTGGGTCCACCAGGCTTCTGGAAAAGTCCTCAATGCAATAAAAAATTTCCTTCTT 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rCer/2227/25_1811_CCS ATGGGACCGCCGAGACCGCGTCCGCCCGCGAGCACAGAGCTCGCCTTTGCCGCTCCGCCGCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCTT + BD(CA?=9;:DHD?B;B6CAG>IC/BBEI@AE?<:@IGF%BFHDH;HCA:BF7@BFA75E-IFFI;?D229HD9C7<>HI@:GIDIBGHJDHFGIAAGFEEBAG@DHC>>9?HGFHFDF@$=A9:DFFGBB3IDFEBDCEA&:CDG@F>DH9=>7@@>@GDFD0;A.FE>3EGED;HEH$0@:@B9A>GIDDAGB:=A7@D@C+EEC=8B<@FC-<921;:;?A@:>=93A<;=%>ABCF7EDE?5C<AE7DGE?=@AF;E=+@:4/B?@GG8G@EIEDDA>GIEHB?=H2;CFCG@GC:?@7BBFDGB;7>I?DB=A9@G>?4EC?HBHAHC?>B;CDBEE;B2C>HGFF=4DFECCD9DB;:@AEFH?:G:@DGHDHIF*DC=:E>@3FBB(@CCBD=E7C?F=49:;=DE<>FC3FF;IIH=F;IBJFF.=AG4DGFEG==8>:FIHI3:<.>(<4BCHECE?CD=<;CFEDDIIDAEHA>HFEEAIGHDAA@@HC@@2EDFFGCHII?HD;BI>&CAE6DIHEHFGEEH5GIEGII@@EJH?AGH&<<9FG?FAHCGECG,DD1E@=>=<1;1C2BGDC:9>EIAI/GFFG;D;D;;6D8>@G>E?HAIC/HI@;E?FGF>>D=@BHGE;;AEG=BEGB9HF9>CHF>EE?98B;GDF>BDHIHDIHAI0CCAI?<6E@:@;HHFG;JHD)??BCIAEFIFFF7EDD:DEIAIBGIHCDGHCH9.HD?3>7=8ACCE>DCAC2ACDF9A7CG<=@B<>@ACF4DAACEC??C?>=E@CE@A;>D>@B=@:DD2A?GB>BGCFD8AEE@=;8@;A?9ABC8D2=D:DDG>BBEF9?B8?DCBCGBBCEG>AF;A?>=8E=4:AEFDDFF9CCCGBE;??<?E;CD.FB?:CFED@<54CE0FD@AG@A$BDC@@?B9@D>DDDD;>9E?EC=?A?7E?EC@@E@DB@E@A?C9E.78=><;@CDC*DA<928=@0A>=72:@FCF9G7CBFCDB>-CABEB@B@@B8@EA?F?<@BEDAE@:<6C=BEFAFEEE;=@@E;F?;=EFD5@AE(F@>61?A'BA?:AFBGFAFDDEB?>F>GE*80EC=@A5F0>;8DC@AAE?C;;@@F0AFGE=F@EED;@B;8<=E>BEAEEDC:;6;FDB0@ED>)BCCGF<;(?@C8A<=CEC@EEE><=B=B;AC:EFE=GE@C+??B@GGC@E-@DB:AB>EEEDB@A>CA;?AC?CEC=?@BCB?CE>F@B:A>CEEFDDBC5B=E @rCer/2229/1765_62_CCS ATGGGGGCAGTCGGTGCCGCATCCTCAGCCCGCCGCCATGGCCGCCTACAAGCTGGTGCTGATCCGGCACGGCGAGAGCGCATGGAACCTGGAGAACCGCTTCAGCGGCTGGTACGACGCCGACCTGAGCCCAGCGGGCCACGAGGAGGCGAAGCGCGGCGGGCAGGCGCTGCGAGATGCTGGCTATGAGTTTGACATCTGCTTCACCTCAGTACAGAAGAGAGCGATCCGGACCCTCTGGACAGTGCTAGATGCCATTGATCAGATGTGGCTGCCAGTGGTGAGGACTTGGCGCCTCAATGAGCGGCACTATGGGGTCTAACCGGTCTCAATAAAGCAGAAACTGCTGCAAAGCATGGTGAGGCCCAGGTGAAGATCTGGAGGCGCTCCTATGATGTCCCACCACCTCCGATGGAGCCCGACCACCCTTTCTACAGCAACATCAGTAAGGATCGCAGGTATGCAGACCTCACAGAAGATCAGCTACCCTCCTGTGAGAGTCTGAAGGACACTATTGCCAGAGCTCTGCCCTTCTGGAATGAAGAAATAGTTCCCCAGATCAAGGAGGGGAAACGTGTACTGATTGCAGCCCATGGCAACAGCCTCCGGGCATTGTCAAGCATCTGGAGGGTCTCTCTGAAGAGGCTATCATGGAGCTGAACCTGCCGACTGGTATTCCCATTGTCTATGAATTGGACAAGAACTTGAAGCCTATCAAGCCCATGCAGTTCCTGGGGGATGAAGAGACGGTGCGCAAAGCCATGGAAGCTGTGGCCGCCCAGGGCAAGGCCAAGAAGTGAAGGCCAGCGGGGAGGATACTGTCCCAGGAGCACCCTCCCTGCCCGTCTTGTCCCTCTGCCCCTCCCACCTGCACATGTCACACTGACCACATCTGTAGACATCTTGAGTTGTATCTGCAGATGGGGACTGGTGGCTCCCATTTTCATTTTAGCCATTTTGTCTTCTGCACCCACTCCCTTCGTACAATCTAGTCAGAATAGCACTTCTAGAGCACAGGTTCTCAGTCCAAGCTGTGGAAAAGCTCCCCTTATCCAACAGAGTTTAAAGGTAGTAACTTGGGTTTTTGCGAGTTGTTTACTAAGGACTTGTGGGGAGGAATCATGCTAAGCCATGACCAATGAGGAGAAGCAACAGAGCCTCTCTGTCCCCAGGAGCCAGTCCTCTGCTCTTCTGCAGTCAGGCCACTGCCTGGGGGCTCTAGTCATTCCAGTGGAAGATGATGTAACCTGCATGGTGATGTGACAACTGTTTCCTCCCTGACCCTAGAGGACCTGGCTCTAGAAGTTTGGGATCAATCCTGAATTTAGTTATGTGTTACATTTACTTTTATTAAAAAAGTATAGTATATATAAATAATACAAAACAGTAGCCCTTCTGGGGTTTCTTGTGGCGGTTGAAATAGTCCCACATGTGGTCATCAGAAAATAAGCCATTCCTCATACCAGTATGGGATCAGTTCCTTGACCTCTGAGGGGCAGGAGTGCTTCCTGCTGTGTGTGTTAGAATCCCTTCCTGCCTTGTTTCATGGCAGTGAAACGCCCCTTGGTCCTGTCCAAGTGTGTCTTTCACTGATTTCCGAATCATGTTCTAGTTGCTTGGCTCTGCCACATGGGTCCAGTATTCACCTGAGCATAACTGTACTAAATCCTTTTTCCAGATCAGTATAATAAAGGAGTGATGTG + KKKKKK.KKKKJKFKJKGKKK;KJIKKKKKFKKIKKHKKKKKJKKHKKKKDKKCIFKKKKJAIKKKIKKKKKKKKKJIKEJKKKJKJKKJKBIKK9KKKKKJKKKKKJHJKKKKKGIKKKKKKKKKKKHKK?KKKKK@KKKKK=KKCIKKKKKKIKKKKKK7FKJ=JEKIKKIKKKKJJ>=GI'IJKKKKJKIKFHIJHKKHJKIKKKKKKKKKCKKKGIKKKKKJFJJJCJKKFK/HKKHKKKKKJKJECFK2KGJJICKKJKKJKKKJKKJIHK>JKI9JIJKFEDKKKBKKKDJJHKDKJ;KHJKKKK>JJKKIGHFKKKJKJJIJKKKJKBHJJDK7KKKHDK?F<1DG9KJD5HJ?KJJ>K@KKKKKIKGKJKDBDFFKI4JJGKGJK@EHIK'JK>JJKGKE?JKK)KKIA)EIKKIKKKKIKKKKKKK7KKKAKJGKJFJKKJFKKKKF?GJFKFK:HKKKKDKKJDHKJJHIIE?9FKGJJCBDJJIDKKKKKJKGKKKJKKKFKKFK@KKKJKKJKHKKJKKKK6KJKK@KJKKKJKKKKKKIFKJ=KKEGJ6CKKKIKKJKHKKKJHKJIKKJKJKBKKKKGKKHGKDKIJJFKKK@KKKKFKJKKK0KKKKJKGCJKJGJJJKKHJJ@JKKKKKKKKKJK:KKKKKJIJKKK+FBGJKJKKKKJKIGJKKEKHKGIKKKKCKAKDJKJ?JKKKK32JJDKKJEJKKJKKKIKJIJKK,KKKJGIKKJK8KKKKK:KK?KHGJJKHIKHKIKHJ:IKKKKKJJKHJKJKHKHHFIIJKIK7JKIKKKEKKKGKKDIKKKKK9KKKKKKJJJJKKKCIBFKJJJHJ3JGKHKKEJGKJKHBKHGKKKKHHKJKKFKKKKKJJIKGJHKKIGBKKJJKJKKKKBKKJKKEJKHJ@JKHKKKHKJJKKJKKKK< @rCer/2233/25_2257_CCS ATGGGAGCTCGCGTCTGCGCAGTCCTCCGCCGCTAGTCGGAGCGAGCTAGAGTGAGGAGACCCCCGCCGGCCAGTGGCACTTGCTTCTGCGGCTAGTCCCACCCACGACCGCAGCCCAGCAACTGGAAACGCAACCGAAGCCTGGGCTGCTCAGCGTGGGAGGGCTTCGCGATCTTGGGGGACCCATTCGAACTTGCAGAGAGGACCGTGGCTCTCCTGGCCTGGAGAGTGTGAACAGGATTGTGGACTCTTCCAAGATTTACAATGATATGGTGATCCAAAGACTGGAACCAAAAAGATTTGCTCAGTGTTTTAGTTTTAAGAACAGTAAATTGTCTACCAGCACCCATCATGGCTAAAAGTGCAGAGTCAAACTGGCAATATTTGGGAGAGCAGGCGTGGGCAAGTCAGCTCTTGTAGTGAGATTTCTGACCCAAACGGTTCATCTGGGAATATGATCCCACCCTCGAATCAACCTACGACACCAAGCAACCATCGATGATGAAGTTGTTTCCATGGAGATACTAGACACTGCTGGCAGGAAGATACCATTCAGAGGAAGGACACATGCGATGGGGGGAAGGCTTTGTGCTGGTCTATGACATTACTGACCGAGGAAGTTTTGAGGAAGTGCTGCACTTAAGAACATCCTAGATGAGATCAAAAAGCCCAAGAATGTGACTCTTCATCTTGGTTGAAACAAAGCTGACTTGGACCACTCCAGCAGGTTAGCACAGAAGAAGGAGAGAAGCTGGCCACAGAGTTGGCTTGTGCTTTTTACGAGTGTTCTGCCTGCACTGGAGAAGGAATATCACAGAGATATTCTATGAGCTGTGTCGAGAGGTGCGTCGCCGGAAGATGGTGCAGGGCAAGACGAGGCGACGCAGCTCCACCACGCACGTCAAGCAAGCCATTAACAAGATGCTCACCAAAATCAGAGTAGGCAGCCCAGCTGAGGTGGACCACATAATTGGAAACACTCTTCCCCTTCTGTTCCCTTTCAAAAATAAAACGAAATATTGCATTCTTTGTTTGATTCTGGAAATGTCTGGGCTCCCATGTTCCCAGCCTCCGTAGGTTGGGAAGTTTTAGCGTTTTTATGCAATTTCAGTGCTAACAACTCTTCCTTTCCTGCTTGAATAAAGAACACTCTAATGGCATTTGAACATGTAATCAGCAGAGATTCCGAAATGACTGGTTATATTAAGCATTTTTTAGGCATCTTCACCTTGCTTAAGTAGGCTGAAGTTTTTTCAAAGGCATTAAAAATTCAATTTCTTGTCAGATACTACAAATAATTGTCTTAAAAAGTCTAAGATGCAGAAAATACAGTAAAAACACAGGAGAGAGAAGCTGAGCTATTGGAACAGGAAATAGAAAGAACTCTAGTTTCTGTCTGAAGTGAAGATTTTCTGAATTATCCAATACCATCTAGGTTTTCTTTAACATTTTATTTTGTTCTTAAGTTCAAGCATCTTCTCACTAATGTTTTTCACTATAACAGAGAATTCGTTTCAATTTTGAGTTGGTTCTCTCAACGATCTATTTGATCATTACACCCCTAATTCTTCCTCCGTGGCTCAAACAGTATTTTTGCTGTAACAAAGGCAGCAGGAAATTCAGACCCTGCTGGGCCTTTTTTCATCAAGTCAGGGTGATGTAAAAACATTGGAAATCTTTTCACCAAACCCTGAACTTTATCGAATGCTTAGTAGAAGATGTAGAATTAGAGACATCTATTTGTTTATCACCTAGCAGCAAACATAGTCCAAAAACAAGAAAATTAAGAATGGAGCTTAACCATGCCTCCATTGGGAAGTCTAGTTTGAGTCAGGTACGAGTAAGAAAAATTAGCCTCTGATTCATTAAGTCTGCCACATAATTTGTTTTGATATTTTGGATACATTAACTCACTTAGGAAAATTCAGAAAACAATGGGTGATTAAGTTCATTACAGCTGAATAAATGTGTCTAAAACAGATTCTTGTATCTGAAAGTACAGTCTACAACTGGTAAAACTTTGTGATTCTTTTCTCCCATTATGCCCTATATACCAAGATTTGGTACTTTTTTTAGTAGGAAAATATATATCTTTTACATATGTATGTATTTATAAATGCATAGATATATGTATAAAAATTTGTAAGAGTTGGAGGCATTAATTCACCATGCATTTGGCAACTTGGTGTAACTGACTTTATTTTATGTGACTATAATAAAAAGCATATTTTC + ,,$-,')-,&)+)($++#*,%++$+&((,(-,*+-,-,(-,)--,))'(((*+--())(&#'***,,,#+%))+,',((+-.--,-'+-,)-,'$+(+--,*----*,-.-(,((--(()**-,(+(--,,*&%$**(,(,.-,..*$&,,(,,-,,#'&%$')*-.---,-*&&-'-,+,,%,+*,+#)(,)(+,---+--)-,),*-,-)(),'-,(,(---.,,,(*+%+),+%&'%',+,(-,(),-.++&++,&+++--.-+----('')#&*-(--''--)-&++-)----)+(++*,,-,---)---,'),..,-)(,*((((-+,.-+(('(&)--,',))+%,,&-,(+...-,&,--+$(*(,((,(-+%+++)--()++*++)+'*'$%$*,*,-)-+()(&*'-+,,+%''&+%**-,,(#((%+,,,-)-,,,',&$)(.*,-,)+&--,,..+-*-.,))-,'+,(+,---.)-,#)-,.(,&((+,,+((,*+.,&-,'-,*(*,*,(&)))),-----(*%,(,,.,.----,-((,,,+,)))-()+,*+--,-*,+&,*),,,.,*,)-+&)+',((),*,,)),,)*+*,-,*-,%*-),)&,--)+)*,,,,)))'%(+(,+-+&(*+&'-,**(*,,),+-&'')+))*-*--*--,,',),,#$+-,,),,+,-&*,-)&------*(+()-+-.--*+.*$*-)+#++*-----,.-*-,--*,+(,')*'+*-)+,,*,%+'-,)-,,),$+,,,+*-+,(%)))),)+)+*--,)-,-,,$+),-*----,),('++-.,),*-++,-+((--)+,,),*(-,--+&&$%,-,--+-(,--)---,.----,(-,-,+----))*-(),,--*(,--').,+''',.*,.,,-'-(,,),--,)+(---*((*#'#').-,))---)(*--(,*(+(',(*,+&,'-,.&+(+--,,&+*...,.)----&-+&-+*(--,*&(,,,,+$,,+--.*,,),+%,(&#+,**,.-($+)..,(,)+&,+)$',-+$++-',)$++-'%,+*,*)'-)--(-,)+--,,)))$-..-+*+,.)--,*+((+%$,(+-##((((*&,,'-,,*+.+-.,%,(&'%',,'(,%*)+.-*'(,,&+*)---+.,,-,(*,-,,&+(,&#&%%&&'''''''(++*')(*##$"$&#$$)(--),,)-,.(,-,'))*(&%%)&&*&-*&---+-,'))$-+'&/(-+(%$'$%1.+-/)1).*()$*-&,-1(,)---%(/*,**'1110/+,,//))'$*(&%-,+''&$$$#'((+)+-%"#($%$)(*-%%'*+/.0+')*0),-/(,*/210/&/+),+,,0001)'((*))..,*1$%/(-/*),1.+2.+1.//-*+'1,/40.56.4+2+2333,6525)0)042)$-),)%+*,.-1/03-+//.'#./0'+/514-..,)4.30%)%')-/)/0)$'((*-+),.+$%-$*)*+//#,'*.01-,+01,1.-++**#(/0-,*-/2+(''$&+)(+,0$"$))''-0,//-3/013+21/'(-.21.,)-0)/+%34354300/(-066*.03-4/66554+.05-/$+),0/0103.312-*(()0./(-/+-,111/+.)---100*/-,,.-1,-1'+)()$)''.-+-'&*./-,$%(()+)(,'),(+)++),,**,,--,,*$%$+)&')*,+*&),#*,)&&##'&#%&%%$%)$)()+*$#$%')))'%(+#)((%&%$&(%#$(**,'*'(-,%,',*((+))$($"',+-++*+'+*'&#'*'*-+&*%$)+)))+,&(,+*&-(+)'))+(+*,(,(*+),)&-,'%(--,,)+'-+-(,+'')'),&&',,)$#&)),%)+)*(('*%(%%$$'%%',+-*'*#'#&,,)'-,-*)'-*)-,,.-%('&%&&,-)-&(,-),-,.-))%.10&/-,/.,0/10*,-0-0102,%-*)'$()),',)+/&*,..,%2.%%(),,%1,$%$&'((.--(,.1+$(&++%.$$-0.),0/$$$(*,&+,(++&*(---,(,+----++-+,&,,(&&++,+,,,((*')++*'),,*----)-++'*)(-,,-%**'-,'+-*-+.--)*$),**$+*&(&,--,.)-))((,%,&,*'--,)---*)++,++),,,.,%*+,+,*-+'#)++( @rCer/2236/2025_52_CCS ATGGGGAAAGTCGGAGGTAGCAAGATGGCGGCCGCTGAGGAAGACTGTGGTGTCGGGGCAGAAGCAGACAGGGAATGGAGGAGCTTCTGGAAAGTGCTCTTGATGATTTCGATAAAGCCAAACCCTCCCCAGCACCCCTTCTACCACCACGGCCCCTGATGCTTCGGGGCCCCAGAAAGAGATCGCCAGGAGACACTGCCAAAGATGCCCTCTTCGCTCCCAAGAGAAGTTTTTCCAGGAACTATTCGACAGTGAACTGGCTTCTTTCAAGCCACTGCAGAGTTCGAGAAGGCAATGAAGGAGTTGGCTGAGGAAGAGCCCCACCTGGTGGAGCAGTTCAAAAGCTCTCGGAGGCTGCGGGGAGAGTGGGCAGTGATATGACCTCCCAACAAGAATTCACTTCTTGCCTAAAGGAGACACTAATGGATTTAGCCAAAAATGCCACTGACCTTCAGAACTCTGGCATGTCGGATGAAGAGCTGACCAAAGGCCATGGAGGGGCTAGGCATGGACGAAGGGATGGGGAAGGGAACATCCTCCCCATCATGCAGAGTATTATGCAGAACCTACTCTCCAAGGATGTGCTGTACCCATCACTGAAGGAGATCACAGAAAAGTATCCAGAATGGTTGCAGAGTCATCGGGATCTCTACCTCCAGAGCAGTTTGAAAAAATATCAGGAGCAGCACAGCGTCATGTGCAAAATATGTGAGCAGTTCGAGCAGAGACCCCACAGACAGTGAGACCACTCAAAAGGCTCGTTTTGAGATGGTGCTAGATCTTATGCAGCAGCTACAGGATTTGGGCCATCCTCCAAAAGAACTGGCTGGAGAGATGCCTCCTGGCCTCAACTTTGACCTGGATGCCCTCAATCTTTCGGCCCACCAGGTGCCAGTGGCGAACAGTGTCTGATCATGTGAAACACAAACACGTTTTCCTCTCTCAGTCCCAGCCATGGGAACATCTGGAGTCAGCAGAACCATTGGGACCTGAGGCAGGAGTGTCATCTGCGGAGAAGTCTACCCGCTGCCCTCTGTCATCCCATTCAAGATTGTGCCATACAGCTGAGGCTTTTTCCTCTGTCTAGGAATAGGGTCTGTTTCAGAGACCATTTCTGTGACCCCTACTCCGTTGTGGTTTCTGCCACTATCAAAGTTTCCAGCTACCTGCCAGGTGAAGGAAGGCATCCTTTCTGGGGCATGCACTTTCTTTCCTTTCTCAAAATAATTTTATATGTGGCCACACTGGTGTTCATCTTTGTGCCCAGGGTCTTTGTGCCTTGTCTCTACTCCCTCTCTTGGATCTGGGGAGGAGGGACAGACTCCTGGGACTCTGTATTTCTATAGTTCTCCTGGCAGAGCCTTTGGAATGGGGAGAAACAGCCTGGGCTGGGGCAACAGGTCTGTCACTATGCTCTTCTTGCCTTCAGACAGACCATTCTGAATTCTCTAAAGGGAAAGGGCTTTTGCATCTAATCACAATAGAGTTGAAAGAGAGGCCTTAGGATTCTCCTCTCTCTAGGTGCTGAGCCTCACCTCCCTGTTGCAGCCTGAGAACTCAAATTGTTACCCTGCTTCTTCCTACAATGCTGTGTGATATGGGTGGACCCAGCCCCTGACCTTCCTCTATCCCTGCCCGTCCTGCCTCTTACCTCCTCTCTTTTAAACACCTGTTTATCCCAACCTTTTTGAGCTCAAGCTGTGATAAAGAAGGGCCATCCTATTTCCCTCATCTAGTCCATCTACCATTCTCACTGACTCCCCCTCTTCCCTGGCAGACACAATAAAACCCAGTGTCAGGTCTGGGAAATTAATGGCTATTCTTCCCGGATACATTCTGGCTTATTGAGATACATGATCTCTTAGAATCCTGTCCCTTGGTTCAGGAAAGTAGCTTGGAAAGGAGTAGGGGTATAGCTTGGGTCCCTTTCCTGCAGGCCCCATGGGGCAGAATATAATAAATATTTCTGAGTG + ,*,+,'+*%+*&(%'''(%)+(,',,)()&'%%)'*+)-(+%''&+,)/&*&-//+-'00,-)+-1/+.+,+'.+$-+'0*//..$,)0111+-/1/+&0%0'%/*,1.'.()---.-/*-&,-,./01(/1/%*-,&)++*+-+1+,+(*(+/.&)/--',1,//.*$..-%0.++%011/-1..+.-,/(,0.0*,0'0.0-/,*-2--11-0.+&+..1,1110,.,.-+&+%+*,1-+'()%.1100.,02*+)+)*++/+&%+0,+,(+,+*--0*/1*-1/...1-.1*,.2-2./0/'+,1.-/+'0*+++002-.1-121..)-+01-,/*01-%/0-$,-20.2101.+0/*)),00/+)%*-00.0*,*&-/)/,2+0/,0*.0//-100-&+.%+-+*(,'1-.+/,11//'-+&)*,&,)+-*-00$-3405114)616--456/0++.1,/54/3344200-',((&+(&%$%*#5/51/)3//2,1/1+-.+*45540550,42)3./04,).66346622---,-($0+(,,/.20.11)/--03+-03+05143553-,5032+)241../0)/..*(21*+.1/2(43062466310.'21,10.0,1#-6.22/.52412301143*$0,-20-4.3110+.*.+'+.'*15641)/,*522-.33/-/.0+&-*1-$)044.464,4+*-340+-/05-314+5665/223/&0-313255300&)102451633.3,//6412.&3*,+1.+.211+1*.33*1043-2-(+0-+0.3/+12$.-+($/3/1/.-656016)546/*411430(,-.2.0*),0055300+/04&4.21/2---,,1*-/2/.0/0,02%)+))+%'0+,0/.0(-0+102.+*+010//(/+1/,-*,1,**-0%*'--*+1-1)/--$&(&+*(*-5/3.50-/42'2)--2*3330&0100/2/5+/.-1*03%45/2036.2-4+$121/51/5.02.',,+%4-01002023.313.0/32'+2200*/2,04(202.54/4/+,$$*.1/*.-)40112)4-4001*%(44*2.-//1*13/'451524/.-/044-,3/1,*5625053/465361010-12-*-55.423.*&+('0.+'.'3401-3.5.-*0*+/*/'$$0-12/4.1042'+.00.%//3/54566+35416303,414404+//)212**1/)31304,10./062%31*20'-0-&-&)3425340,00/%/204-02115340-*(56/304-2-2*(*25252/(./113*54.)0+12+'/6+25042/,$.*$*-/22..,.41/-/34&0..4/0.'1&.)02232/,2510/40)115*,.--1%42,426145//*052/+2+10*0&4011302*453152530))/*2+.4$../15431%.0(+*+-/&3420&15120+/*1+103('/22/3'111+35//5/-)3/41/00&--3.0200-0/-/01/-+2(*2$0100*5353351)04142-0-(/1+.5462,34231550/,4-4/*20.*0310+//...+-.)(++%*,,*)&'.21+(-',&/4/62634-330&,42(45663/)312160/)0'+/+-5-)./0422,/104+2/4.44).-04+2(2.,/11(055,',30113.*-,435+44045-1$(0413154)35%021*,00)(0)'(2-051/0$.2555,*1,(0125+1,1111'2500014,344)/353'25)55554116/3/365/36.3)5//502.-*)./$+4+3)0/)33-/54/.-0,)*(45142235410$21451442(26501530,44-*6(,/-.24,554-1+'4(66/6/5521143+2/&143624/4232+-1&43365+$#,0/%43555'3&/5.21512/60.,-+/%/4/2//. @rCer/2237/25_1793_CCS ATGGGCACTGGGGGCCATAGGGGGGCTGGGGTCTCCAGGGAGTGACTCTTTTCAATCTCTGGGCCAAGATCACATGCAGGATACCATGGAAAGGAAGGAGCCCTCTCCACTCTCCTTCTCCAGAACCCCCTTTGCATAGTAAAGGGGAAGGGCCTTTGGGACCATTAGTCCATTTCCATTTTACAGACAAGGAAATCAAGACCTAGCTTGGGGGGAAAAGCCACCCCTGGAGTCACCTGTGTGTTCAGTGACACCCCCAGCCTGGGTCCCCTCCTCCCAATAGAGGCTGAGCTGGAGCCAGGGCAGTATGAGGTAGGGCTGCCACTGCCCATACCTCCTCCTCCCTTCTTTCTTTGAAGCCTAATGGCCCCCAAAAGATGGGCAGGACAAGCTGTAGCCCATCTGAGAGGTTGGGAAACAGGCCCAGAAACAGGAAGTGACTCACACAAGACCCCTCAGCAAGGGCGCAAAGGGGGAAGAACTAGGGGCTCCATTGTTCTTCAGGCAACAGGAGACCGTTGCTCCAGTGCATGTCTGCTGGGACAAGGATTCCTGGCCTCTAAGCCCTGGGCTGCATAGCCCGCTGGGCTCCACCTCTATAAGCCAGTGACTTCCTGGGCCTGGGTCTGGGTCTGGGGGAGAGGGTTGCCAGGGAGACTTAGCTCTCCTGGGGGGCTGGCCCAGCTGACTGAGGGTACACAGGATTGGGTCTAGACCTTGATGCCTGGGTGGAGGCCCCCGGGAAGGGGCCATCGCCTCTTCAGGACCAACTGGTGGGCGAGTTAGGAAACACCAGCTCCTGCCTGGGGCAGTGAGGGAATGGGAGCAGCTGTGGGCGCCTCATTTCAGGGAAGTCGCCAGCAAACCTTCAGATGCAATGAGACCTGGCCTTCCTATTGTGCTTTTCAGACTTTGTTTTCAGAATGCTTTTACCTCGAGTGTGCGCTTCTGCCCTCACAAGAGCCCCTGGGGAGTAGGTGGTGGCCTGTGCTGTCCTCCCCATTTCAAAGCAGGGAGCTGAGGTCTTGGGAGGGGAATGTGCTCACCTAAGGTCCCACTGTATTAGTGGGTGGGCAGGACTGGAACTCGGTTCTCCAGTAGCCCAGAGCTCACTCTTTTACACCCAGAGGTGGAGCAGATGGCTCTTGGGGTGGTTATGCACTTCACAAGCCAATTCCCTTCAGCCAGGAGCTCCTGGGTGCATTTCCGTGTCAGAAACAGCACCAAGTCCCAGCCCCTCTGGAGGCACAGCTGTTGCGTCAGGCAAGGCTACCTGCGTTTATTTATTGAGCAGCAGCGCTGTATCAGGCCCAGGGACCGAGCCCCGCTCCCTGTTCCCCCATGGTGTCTCCGAGGCCCTCTGGGAGGGCCCCACGTCTGGAGCGGCACCTCAGAGTGGACGGAAAGTATTAGCGTCCACGAGCTCACCCGACGCCGAGCCTGTGAGGTGGGCCAGTGGTGCCCACTGAACCCAGTGCTTCAGGGAGGTCAGAGTGGAGCCAAACCCAGGGCTGTGGGCATCACCTCTGGAGCCCTTTCACTCTATGACTGCTTCCTGGGCAGGTGGCGGGAAGGCAGGAGCCCGGGTCCTTAGGCTGGGGGCCTCTCTCCATCCACCCACCTTTCCCTCATTTCCTTCTCTTGGAGCAGGAGCTGCCCAGGCCTTTAGGGAGGGAGGGTTTCTGGGGCCCCTGGGTTGGAGTGGGGTCGCGTTGCATTGTGTTCATGACCATGTAGCTCATGTTGAAATTAAAGTTTTTGGCTTTTC + KKJKKKKKKCKKKKKKKKK-KKKKKKIDKKKGJHKKJKKKKKKKKKKKJKKKKJKKKKKKDKKKKKKKIKKKKKKKJKKKKKKIKKKKKIKKKKKKKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKKKKKHKKKKJKKKGGKKHKKKKKKKKKKKKKHKKKHKKJKKKKKKKGKKKKKIKKKKKKKKKKKKK@KKKKHKKIKKKKKKKK.KKKKKIKKKKKKKAKKKKKKKKKKKKKKKKKJKIKKKKKKKKK;KKKKKKKKKJKKKKKKKKKKKJKKKKKJKKJKKJKKKKKKKKKKKGHKKKJKKKKKJKKKKKKKKKKFKKKKKKKKKIJKKIKKKKKKKKKKKKIKKKGKKKKKJKKKJKKKKGKKKKGKKKKJKIKKKKKKKK=KKJKKKKKJKKKEKKKKJKKK?KKKK.KKKKKKHKKKKKKKKKKKKKKKJJKKKGKKKJKKKEKKKHEKKK@KJKKKKKDKKKKKKKKKKJKKKKDKKKHKKKKFKKJKKHKKKIKKKKKIKKKKJKKKFKKJBKKKKKKKDKCHKKKKKDKKKKHKJKKHKKKJJKJKKKDIKKKKKG=KKGKKKKKKK)KKKKKDKKJGJKIKKKKKKKJKKKKKKKKJKGKKKKKKKKKKKKKKKKJKKKKKKIKKKKJKKKKKKKKKKKKKKKKKKKKKKKKFKKHKKKKKIKKKKKKKGKFKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKJKKKKKK3KKKJJKKKHKKKKHKKJKKKKKKHKKKKJKKKAKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKGKKKK @rCer/2239/21_2162_CCS ATGGGGGAAGCGGGAGAGCGGCTGATCGTAGTCCGGAGTGAGGCAGAACTCTGAGCAGGTGTCCATTATGGTGACATGCAAAATCTGGTAGAAAGATTGGAGAGGGCAGTGGGCCGCTGGAGGCAGTGTCCATACCTCTGACATGCACCGTGGTATGGAGACAGTCCTTCAAAGCAGGAGCAGCTCCGTATGTGCAGGCATTTGACTCACTGCTTGCTGGTCCTGTGCAGAGTACTTGAAGATCAGTAAAGAGATTGGGGAGACGTGCAGAAACATGCGGAGATGGTCCACACAGGTTTGAAGTTGGAGCGAGCTCTGTGGTTACAGCTTTCAGTGTCACAGCCAGAATAATAAGCTTTCCGATTTGTTGGCACCCATCTCAGAGCAGATCAAAGAAGTGATAACTTTCGGAGAAGAACCGAGGCAGCAAGTTGTTAATCACCTGTCAGCTGTCAGCGAAGTATCCAGGCCCTGGCTGGGTGGCTATGGCTCCCAAGCCTGGCCCTTATGTGAAAGAATGAATGATGCTGCCATGTTTATACAAACCGAGTCCTCAAAGAGTACAAAGATGTGGATAAGAAGCATGTAGACTGGTCAAAGCTTATTTAAGTATATGGACAGAGCTGCAGGCTTACATTAGGAGTTCCATACCACCGGACTGGCCTGGAGCAAAACGGGGCCTGTGGCAAAAGAACTGAGTGGACTGCCATCTGGACCCTCTGCTGGATCAGGTCCTCCTCCCCCTCCGCCAGCCCCCTCCTCCCCAGTCTCTACCAGTTCAGGCTCAGATGAGTCCGCTTCCCGCTCAGCACTGTTTGCGCAAATTAATCAGGGGAGAGCATCACACATGCCTGAAGCACGTATCTGATGACATGAAGACTCACAAGAACCCTGCCCTGAAGGCTCAGAGTGGTCCAGTACGCAGTGGCCCAAGCCATTCTCTGCACCTAAACCCCAAACCAGCCGTCCCCCAAACCAGCCACAAAGAAGGAGCCAGCTGTACTTGAACTGGAGGGCAAGAAATGGAGAGTGGAAATCAGGAAAAGTTTCCAACCTGGTGATGATGACACAGAGCTGAAACAGGTGGCTTACATATACAGTGTGTCAACGACATTGCAAATCAAGGGCAAAATTAACTCCATTACAGTAGATAACTGTAAGAAACTTGGTCTGGTATCGATGACGTGGTGGCATTGTGAGATAATCACATAGGGATGTCAAAGTTCAGGTAATGGGTAAAGTGCCAACCATATCTCAACAAAACAGATGCTGCCATGCTTACCTGAGCAAGAATTCCCTGGATTGTGAAATAGTCAGTGCAAATCTTCCGAGATGAATGTCCTCATTCCTACAGAAGGCGGTGACTTTAATGAATTCCCAGTTCCTGAGCAGTTCAAGACCCTCTGGAATGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAGCGAAGTGCCACTGGGTTCTTTGCCTCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTCTAGATTTCCTCTACCTTTCTGCTCTTAAAACTGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTTGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGACTGATGATGCATTTTAGCTTTGAGCTTTTGGGGTTATTCTACAACAAACAAACAGTCCATTGGAAAGAAAACAGTCCCAGGAATTAACAGATCAGAATGTTCACACTGGTTAATCTTTTTCTAACAGTGAGCATGAAGGTAGCAGAAGCTGGTGTGTTTCCAGATGGTTCTTCTAACCAAACTAATTTTTCACTGTTGACAAGTGAGGCAAGGGTTGCACTGGACCGAAGGCTGAGGCTTGGCCATCTAGCATTCCATGCAGAATGGTTTCCCATAAGCATTCCTTTATTCTCTGTTCTATCCTGGGTCTGCCTCAACCATGAGATAGGAGAGTTCCCGGTACTAGCTGCTATCCAGGGCAGTTAATGGAGTCTTCAACCCTTTCTTTCTCTGGGATCCTGACTAGCACCTTCCTATAGATGACTT 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@rCer/2241/1825_55_CCS ATGGGGAGTCTCTGTGCGTTGAAGCCGGAGACCGCGGCGGCCTCAGCGAGGACCCTTCGCCCCGGAGCCGCCGGCCGGGACCGCAGCCTCTGCCGCAGCGCCCCCACCACCTGTCCCCTCCCCCGCCGCCTCCGCCGGAGCCGCCTCGCGCACTCTGGGGTATGGCCGTCAATGTGTACTCCACATCTGTGACCAGTGAAAATCTGAGTCGCCATGATATGCTTGCATGGGTCAACGACTCCCTGCACCTCAACTATACCAAGATAGAACAGCTCTGTTCAGGGGCAGCCTACTGCCAGTTCATGGACATGCTCTTCCTGGCTGTGTGCACTTGAGGAAAGTGAAGTTCCAGGCCAACTAGAGCATGAATACATCCACAACTTCAAGGTGCTGCAAGCAGCTTTCAAGAAGATGGGTGTTGACAAAATCATTCCTGTAGAGAAATTAGTGAAAGGAAAATTCCAAGATAATTTGAGTTATTCAGTGGTTTAAGAAATCTTTGACGCAAACTATGATGGAAAGGATTACAACCCTCTGCTGGCGCGGCAGGGCCAGGACGTAGCGCCACCTCCTAACCCAGTTCCACAGAGGACGTCCCCACAGGCCCAAAAAACATGCAGACCTCTGGCCGGCTGAGCAACGTGGCCCCCCCTGCATTCTCCGGAAGAATCCTCCATCAGCCCGAAATGGTGGCCATGAGACTGATGCCCAAATTCTGAACTCAACCAACAGCTGGTGGACTTGAAGCTGACAGTGGATGGGCTGGAGAAGGAACGTGACTTCTACTTCAGCAAACTTCGTGACATCGAGCTCATCTGCCAGGAGCATGAAAGTGAAAACAGCCCTGTTATCTCAGGCATCATTGGCATCCTCTATGCAACGGAGAAGGATCGCACCCCTGAGGACGATGAGATTGAAGAGCATCAACAAGAAGACCAGGACGAATACTGAGGGCGGCCGCAGCCCTGGCTGACTGCACGGCTTCCCCATGCCTCCCTCCCTGCTCCACTCCACATTATAGTCCTTTCCTAACACGGTCGGCCGGGTGCTTGTGTCAGTGCCGCAGCACTGGGGAGCCAGACGAGCGGGGCTTGGGGCATGGGGCCGGAAGCAGGCAGAAGCCCGTCCTGGGTGGCGCTGGCCCAGTTGGCGGGACCCCTGTCCACACCCACCCTATTTATTTCTGTTGTCTCTCTGTTGTGTCACCCAACATTTCCCAGGGTGCTGCTGCCACCGCCCCAGCCAGCCACCTGCTCCCGACAGCCAGCAGCTGGTATTTGACAAAGTCATTGGTATATTTACTTACTGGATTCTCCTTGCACTTACCTGTTCTTTTCCAGAGCTGACAGCACGGCTCGGGGCAGTGTGCCTGGCTTGGCTTCCCTTCCCATGGCTGGGGCTGGGCTGGACTCACCATTCTAATTATTTTGTCTTTGGCTTCTCAGTAACTGAGGGGAAGGCTGATGTCAGGAGAGGAGAGGGGCTGAGGAGGTAGTGCCGTAGGCCCAGGGGTCAGGGAGAGGGAGGGGGCATGTGAGGGATGGAAATGACCTCCTGGCACCAGGCCACCCACCCAAGGCCCCTGCCCCAGCACCGAAGCCCACTGCTGCCCTGAGGCCCCCAGCCACTCCCTCCAGCAGCCTGGTTCACCACACAGACTCTGCCTGACCCCATTGTCTGTCTGCTTCCCACCCACCCTGCCCACCCCTGCCCCTCAGGCACCAGCCTGCATATGTGTCACTTTTATTTAAATAAACTTGTGCGTAAAAG + @<=>A//193>JIIDDCGJCFK8GG?I>7?BI;HIJEDH@KCJK:KKG=KDGKK0K;JJKKJ)G/HJKJJIAKCJ;JK*:K8FIDKKJKJBIKDHI=JKJHJKJ5AI?BJGKHIKJK8GCGIK'BK5HKCGJGKHCG:/@KJKK4HGJGKAIECE=JJK*IEBK>K>HEHI13JH=BAHGG)HFHEJ8B7BGF=GI=E8CCJJJH>FAIEIDGCADA(>GG;B,;>D/82*98@'I/=EA.FF,B4IAFH;CJ=J>FHK0C:;G@BFDCKJ7AHKH=?3JCJ>8CGDD>JAG6>?4?4?-5F;;@C/;;+8B1@0CED;B:E3/7456==;:83@@2>8,;530<;8@?=EEE40=>BBF@EA<:B?:;B6@*=@???C=;955:&C8:9D735<7);>&<<.7%67&<:573):;*52>:4*$<8<*=4=8B;3=5=:1?/>E2=574%.6?2>7)'.(96:B3:D>?.>>B@2GADGEFEA??AFE<0-A-?C:@BCCE5><>6G;=95=:A>C@=3CCB$?7AC:?<=BA&B::=A6:9>BC0DB0<8CEEC@D'@C?0=3>E;A69=<=?>A>;8B<(<:&B69$BE0DBA@*@(G5039?BG98F?8>)>=AC(?@C0;BG9D9F1FDC>><9,?9=:;&6;2=??2>=*BCB@@6<=998:;5CE@8C.2->>4;>4)$&(=00,6;3+9=<%;;;A71AC@B@<><@.@@7:.9A?A<4(6@,AD*:A7:@A<ED-3F:6.D9<7=A>FJ3-C5EHF&>BCD/1BG/;EI-<7;)>+7C=@8<<&8:>;C6@F/95@C(;@@;=:DDFA;C<:89/C9CAB3D?C79@;F?@9DEAB79@(>6>/EA2B<;&B8E:=$?AEB8>66B7?D?;@6=8;@16>D4E9?AC(:<=;%:B;@7>23@F6>@?3:9@<';AD5A9AC1C:9><;9699$<<<11=D2*@-429+&9B11A>)C?4.==&>E2:A*?9@C(:AE?B:E<>A2=;<&CD.<9?/;C5@C@C@B;%.1<8:'>>C=>/9>DFAAF629/+87$-9@0;B:G;18)54=7B4CE@;;'67)8;<*;=??(G?>=B;7286B*FF@>>%579<=='B=;>=45E;A,=@?/59AFB.C??D&A6F7>6?98A'6=628@B4@0>@A$C1A.50@A;:>?<>523+D&/21?BC);AB=8';>&4,511A=E@9FA??0:AAC$8BBDD+:54<:%3CAAC&;AB:73;;@(64D.@C7@A>?'4@>@F7B;56C;DEBBFD>D<3BACCC=2@D=CC>2C8:D38&/>=;25=:C;@9776;B7:A929<79:-$547?CC0>FF0@:$=?@)B>%;25:$1>B<4; @rCer/2242/25_1754_CCS ATGGGGCAGCAGCAACAGGGTGCGGCCGGGTGGGAACGCGGGAGCGGACCCAGGAAGGCTGGTCCGCTACCGGCCCCTGCTCGGCTTGCAGGTCCCTGCGCGCCCCCGCCCTTCCCTAGACCCCAGCCGGGCCGCCGCCGGTGTCCAGGAAGCTCCAGCCTGAACCATGTTTTTCACCTGTGGCCCAAATGAGGCCATGGTGGTCTCCGGGTTCTGCCGAAGCCCCCCAGTCATGGTGGCTGGAGGACGAGTCTTTGTCCTGCCCTGCATCCAGCAGATCCAGAGGATCTCTCTCAACACACTGACCCTCAATGTCAAGAGTGAAAAGGTTTACACTCGCCATGGGGTCCCCATCTCAGTCACTGGCATTGCCCAGGTAAAAATCCAGGGGCAGAACAAGGAGATGCTGGCGGCCGCCTGTCAGATGTTCCTGGGGAAGACGGAGGCTGAGATTGCCCACATTGCCCTGGAGACGTTAGAGGGCCACCAGAGGGCCATAATGGCCCACATGACTGTGGAGGAGATCTATAAGGACAGGCAGAAATTCTCAGAGCAGGTTTTCAAAGTGGCCTCCTCAGACCTGGTCAACATGGGCATCAGTGTGGTTAGCTACACTCTGAAGGACATTCACGATGACCAGGACTATTTGCACTCTTTGGGAAAGGCTCGAACAGCTCAAGTCCAAAAAGATGCACGGATTGGAGAAGCAGAGGCCAAGAGAGATGCTGGGATCCGGGAAGCCAAAGCCAAGCAGGAAAAGGTGTCCGCTCAGTACCTGAGTGAGATCGAGATGGCCAAGGCACAGAGAGATTACGAGCTGAAGAAGGCCGCCTATGACATCGAGGTCAACACCCGCCGAGCACAGGCTGACCTGGCCTATCAGCTTCAGGTGGCCAAGACTAAGCAGCAGATTGAGGAGCAGCGGGTGCAGGTGCAGGTGGTGGAGCGGGCCCAGCAGGTGGCAGTGCAGGAGCAGGAGATCGCCCGGCGGGAGAAAGAGCTGGAGGCCCGTGTGCGGAAGCCAGCAGAAGCTGAGCGCTACAAGCTGGAGCGCCTAGCCGAGGCAGAGAAGTCCCAACTAATTATGCAGGCGGAGGCAGAAGCTGAGTCGGTGCGGATGCGTGGGAAGCTGAGGCCTTTGCCATAGGGGCCCGAGCCAGAGCCGAGGCTGAGCAGATGGCCAAGAAGGCAGAAGCCTTCCAGCTGTACCAAGAGGCTGCTCAGCTGGACATGCTGCTAGAGAAGCTGCCCCAGGTGGCAGAGGAGATCAGTGGTCCTTGACTTCGGCCAATAAGATCACACTGGTGTCCAGCGGCAGTGGGACCATGGGGGCAGCCAAAGTGACTGGGGAAGTACTGGACATTCTAACCCGCCTGCCAGAGAGTGTGGAAAGACTCACAGGCGTCAGCATCTCCCAGGTGAATCACAAGCCTTTGCGAACAGCTTGAGCCTTCAGCCCTCACAGATGCCCAGCCTCATAGCTGAAGTTGCCTGAATGATCCTCCTGTTGCATGTAATCCACTGGCCTCCCTGAGCATGTCCATTGACAGTGAGGTCCCACCCCTCATCTCTCCTTGCCAAATAGTTTGTGCCTTGTCTTGAAGGGGGTTGCTCCCTTGCCAACCTCACACTGCTATGATTGCCAACTCCAGCGGTCCCATGTCAGCCTTCTGATGATCCCACTCCACCCCATCTCAACTTATTTAATTCCTAATTAAATCAGACTGTT + KK:KKKKKIIKGKJKKKGKJKKKHKHK6IJJ(JKHKKKD9KKKKKKKG?KKKKKDK6KKJKKKKKKKIJGKAKHKKKJKKIK:KKCKKKJFKJEKKJHGKIF:HJKKKHKKKK>KKKKKKFKKKKHKKCKJ=IJFJ>JK5JKKKIKJIKDKKKJKKKKFKGKHKIKKKK8KKKKJFKKCJKKKJFKKCKKKKKKKKKKKKKKIHKBKKKIKKKKKKKKKHJKKCKKKKDKKKKKKKJKAKKBKKKKKKKKKJKIKKKKKKKJKKKGK/KKKKKAKKKKKFKKJKCKKKFKJKHJKHKHKKKKKIKKKKKKKBKKKKEK@KKKKKKKKKKKKKHKKKKKKKKGKKKKKGKKKKKKKKKKKKKKKKKKKKKKKKKKK&KKKKKKKKKKKKK>KKKKKKKK,KKKGKKKKKKKKKKK6KKKIKKJKKKKKKKKKKKKKKKKKCKKKK@KKHKCKFKKKKKKIKFKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKJKKKKKKKKKKKK&KKKKKKKKKJKHKIKKKKKKKKKKKKKKKKKKJKKKKJKKKKKKKKKKKKK*KKKKKKKIKFKKKKKKKKBKKKKKKKKKKKKJKJIKKKJKJKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKIKKKKKKHKKKKJKKKKKK?KKKKGKIKKKKEKKKKKKKKKKK9KKKKKKKKJKKKKKKJKKJKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKFKKKKKKKKKKKKKKKKKKKKKKKKKBKKJKKK;KKKKKKKKKKKKKKKKKKCKKKKKBKKKKKKKKKKJKKKKKK>KKKKKKKKJ%KKJKKKKKKKKKKJKJKHKKKKKKKJKKIKJKKKKKKKKKKK:KKKKKKKKKKKKKKKKKKKKKKKKKKKKKK/KKKKKKKKJKKKKKJKKKKIKKKKJKHKIKKKKKKKKKK?K @rCer/2243/2735_63_CCS GGGGATGGCAATGGACGCTTTATCGAGCAGCTGCAGGGTGGCAGCCTACAAGAAGATTGGCTACTATGACAGCACGAAGGATGATCTTTTCCTGGTCCAAAACAGATAAGTGGATTTGGAGGGTCCCCCCCCAGCTGACCAGACCCCCTGGTCCATCAAGACATTCCGCTTCTTGTCACAGAAACTCTTTTATCTCCGTCTCCGGTTCTCTCCAGCCTGGGCCATTGTCCTAGCTGTTTGTCCTGTCTGTCCTTTAACATCTACAACTCACATGTCCGTTTTATATCCAGAACTCACAGCCCAACCTGAAACAACCTGACTGCTGTGGGCCTGCTCACTGGCATTAGCTGCTGTCCTTCCCCCTGGGGCTGGATGGTTACCACATTTGGGAGGAAACCAGTTCCCTTTCGTCTGCCAGGCCCGCCTCTGGCTTCCTGGGCCTGGGTTTTTAGTCTGGGGCTATGGCTCCATGTTCACCAAGATTTTGGTGGGTCCACACGGTTCTTCACAAAGAAGGAAGAAAAGAAGGAGTGGAGAAAAGACTCTGGAAACCCTGGAAGCTGTATGCCCACAGTGGGCCTGCTGGTGGGCATGGATGTCCTCACTCTTGCCATCTGGCAGATTGTGGACCCTTTGCATCGAACCATTGAGACATTTGCCAAGGAAGAACCAAAGGAAGATATCGGACGTCTCTATTCTGCCCCAGCTGGAGCATTGCAGCTCCAGGAAGATGAATACATGGCTTGGCATTTTCTATGGTTACAAGGGGACTGCTGCTGCTGCTGGGAATCTTCCCTTGCTTATGAAGACCAAGAGTGTGTCCACTGAGAAGATCAATGACCACCGGGCTGTAGGCATGGCTATCTACAATGTGGCCGTCCTGTGCCTCATCACCGCTCCTGTCACCATGATTCTGTCCAGCCAGCAGGATGCAGCCTTTTGCCTTTGCCTCTCTTGCCATAGTTTTCTCCTCCTATATTACTCTTGTTGTGCTATTTGTGCCCAAAGATGCGCAGGCTGATCCACCCGAGGGGAAATGGCAGTCAGAGGCGCAGGACACCATGAAGACAGGGTCATCGACCAACAACAAACGAGGAGGAAGAAAGTCCCCGGCTGTTGGAGAAGGAAGAACCGCGAACTGGAAAAGAAATCATTGCTGAGAAAAGAGGAAGCGTGGTCTCTGAACTGCGCCATCAACTCCAGTCTCGGCAGGCAGCTTCCGCTCCCGGCGCCAACCCGCCGGACACCCCCCAGACCCCTCTGGGGGGCCTGCCCAGGGGAACCCCCTGAGCCCCCCGACCGGCTTAGCTGTGATGGGAGTCGAGTGCATTTGCTTTATAAGTGAGGGCAGGGTGAGGGAGGACAGGCCAGTAGGGGGCGGGAAAGGGAGACGGGGAAAGGGCAGGGGGACTCAGGAAGCAGGGGGTCCCCATCCCCAGCTGGGAAAGAACATGCTATCCAATCTCATCTCTTGTAAATACATGTCCCCCTGTGAGTCCTGGGCTGATTTGGGTCTCTCATACCTCTGGGAAACAGGACCTTTTTTCTCTCTTACTGCTTCATGTAATTTTGTATCACCTCTTCACAATTTAGTTCGTACCTGGCTTGAAGCTGCTCACTGCTCACGCGCTGCCTCCTCAGCAGCCTCACTGCATCTTTCTCTTTCCCATGCAAACACCCTCTTCTAGTTACCACGGCAACCCCCTGCAAGCTCCTCTGCCTTTGTGCTCTGTTCCTGTCCAGCAGAGGTCTCCCCACAAGTGCTCTTTCCACCCCAAAAGGGGCCTCTCCTTTTTTCTCCACTGTCATAATCTCTTTCTATCTTACTTGCCCTTCCACACTTTCTCACATTTGTCTCCCCCTGAATTTTTGCTTCCTTTGGGGGCTCATTCTTTTCACCAAGGCTCACATGCTCCTTGCCTCTGCTCTTTGTGCACTCATGCTCAGCACACATGCATCCTCCCCCTCTCCTGCGTGTGCCCCACTGAACATGCTCGTGTGCACCGCGTTTTTTCCCATGTGCTTTCTTCATGTTCAGTCACATGTGCTCTCAGGCGCCCTGCATTCACAGCTACGTGTGCCCCACTCACGGTTATGGGTCTGCCCTCGAGCGGTGTTTGGGTAGGCATGTGCAATTTGTCTAGCATGCTGAGTCGTGTCTTTTCTGTTTGCACACATCCATGTACTTTCCCTGTGTACCCTCCATGTACCTTGTGTACCTTCTTCCCTTAAATCATGGTATTCTTCTAACAGAGCCATATGCACCCTACCCTGCACATTGTTATGCACTTTTCCCCAATTCATGGTCTGGTGGGGCCATCCACACCCCTCTCCTCATCGCAGAATCTCCATTTTCTGCTCAGACTCCCCCCCATCTCCATTGCATTCATGTACCACCCCTCAGTCTACACTCACAGTCATCTTCTCCCAAAGACTGCTCCCTTTTGTTTTGTGTTTTTTTTTTGAGGGGAAATTAAGGAAAAATCAGTGGGGGCAGGTTTGGAGGGCTGCTTCAGTGGATAGTTGATGAGAATCCTGACTAAAGGAAGGCACCCTTGACTGTTGGGATAGGACAGATGGACCTACGGGGCAGGAGGTGGCGTCCCCTTTCACACTGTGGTGTTCTCTTGGGGAAGGATCCTCCCCGAATCTCCAATAAACCAGTGAACAGT + *)($()-*&##%'$&&&())%(&)))(&*()%&&((,'-.+(+/.%&))0(-2.102.210-(.')+-&+011+&00*/(,..+/+))(#1+-./*-&,0/),0)$(,,3,*)*+.$*('/+(.+(+20,+$*+-...3'/+%%-,,%31(/1&.$)/$),+3306/,/4...$,)'2-,,/.%+,%)12+00,+0-+1%&$#-..,,0('+%03(,/1313(,3'1-0&%&201.&/'0-+%21-'3,++%.(&-++)3-*10.&3/)(&)/&+3(.-)&#))''52'/4+3-34/4'11(+'+))-1-&,1./0)..-.&((*,+/)'#)+(121010(*++#)+()*'*&#"#+'/011-/403($+.*036*3&/1(($,,1%55-0//.)#2$320..0(+.)2+1+020./-,,.%22%/4/3'0.%0-.0.%4%/10(,..1&/4/*0-.*"&,(11.//4#31433.)/'3/20-,+$3.155+/3-/0250,(%*30-.141122-.$1$0243&.4/5/-.430**+21&53,1541&'+"11)2601')).11-134,+33*-565'0)0,$*31/55'-(,,'0*1/0-3/3-2/5+4/,.-,+3//)0*4--143,04)33*-/*3726$2223-6-083667'8:321-$4'.248275*6-6)33136/)%('+(/43+/'()4,745,,+096,7/124')1124--()3-4,$*.5:4996//92+0$5.+(598+301/654'631%-65%22*/3&02047(4//875:1,.2244(71'07+9768+)04'.*.'0036614(5+14015'2$5-+&+%/931/&14-,*3/(50.5372-3--/'/42+/336-8/025(0+3*/*742-5361-)&(/1+10476430)32-/.&5*11;497569/6.51%+3%&53%/:2/2-7-'.3(71137%6375324&538523.33:980254(.*.401/41+1.6.316;9670)2/.85)0((''*'(03,228.6,065#%.$'0,4*101--(.(&*)%5311/7,427721'-597-'#).0.+3-62,//2,4&72851-552%(*+&*+'.*&4--,/1-47-691655%32*-,/500,1541575*,,+#10*5(.3,,/)/52%/,200%+0/*(%-,.#-*.%1093/6/6'21+33920+411-4(0($#-%'*(+4-0/-43%''/.6-,%466-2*&$(*+./095+*12*)-'23632)12%2)*3;:'468<*3$*;;9(62+-67855$.0:37*<0151-)905>4>70&0.2/((4(,+31('67:+75505-.14;)007.'0/74304;8(-:7:'94;9=20-76<>4:4'0:377*1$46(*':,865803-6/),0#-7,867823.8;86&59<49625+8<839=2$36(;;9036)/1/<<>:7769943/(./0%5929=<45$.2587:4069:49%<56:28.10-'/1;4212241;%9/8:189)06:*/95-+,(428;8;8166734%562(/:77:6;3#1.8;.*72.8026/61%4)06*89793>?547622(29)3+,240)/(10*/29)6.-55-568;75/12$)9:2*+.4-$&417289+32(81/**)35,+20*43716;4*,3-245/50/4:0+11)&('041.64/5%)572)*.,%668+757:95487412*12:08887+,63/..2.454&3323492,181785(:05+(1)40:-0.*,0+71*%*+)-::0,5394323,$-12)3/5:366:4+6-3/(-531/+53433274+0*0/21:91818'1:5+3)*/-55-(+)(/,1,,1)4511$(/*22,*3-'+&2*')102&-+/))0/201)*)'.-&00000--.-,20+42/--00)*)')//1(+'./**++$'*/2*32100213,04//'/30+,-/521).(*&*)250./3/3)(/01)/-1(/./.)*/-'*-1*545.-'*-.,&')'242-,2*-*.)$0134-5520.4..),,&*+&%+'%,$'30/50213,,++/'.-)'&'*(#$./35).13+'-)-2.-$+)4525/6611+3*0,00,41,312+1.13.((-513340)4-1.-51230-4404+++5)010.&/&4515*3-1-'-((&3/$.1,/($')()++*/0)1./((*.-2%132&2,0()*--%0)11)100,)5-3,2.-+))0&$),)3((/,1(+(0443.('.,011.).02+')'#)#**00/20$0(-45'.6450350)%.0,0/-//22%451./143*)(/0-02*,111-3//(/3)+/(.,.0,,-/0)1/,*%..-&-/+**,-,&((-$.-.-+%%+$1/**,).,/.%&,,-(&())$(*0*,/%+%*+)$*%0/0(#((+*%*'(*'&%&(&')-*(.,*())00.,0*,&*',,0.)0*$(,%*2-22/,&,*$(.-,*.1(,/'0+//./&-++'$(,-/(+)'$)+#/1'0-*--/-*,)*/($&/,0*+'(&.&0.*0,#+121)',#(,0)%-')/*%.+))%#%$%.,' @rCer/2245/2205_62_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGGCGAAGGAGGCTCACACCACGCGTGTGCAACAGGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGAGGAAGAGATAGTCGCTCTGGATCACCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGTGACACCTTGCGCTTTTGCTGGGCACTGCGATGGAGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAGAACAAAACTCAGACACAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACATAAACTTTTAATGG + B;;@(8;7?,A>C;<+C@=A=FACBDB;@A=?D5??,E7?5@;%=?B@?:5B58A<>EFB:<=@CA801>>;+;?B4EF@D?@3>@;09<5>490/;7?<+;=?=;8=:-<>>:4<9?:>;;:@99*>:.;;@:'1:6<48=+@CD.7=:;=B6102:;<.67-3*A3;7:<=,>985;,=24959<80<59:*41>::99:185867)9761"%"&"/#'#1$"(''%%'/,0&)%'()+$+,&$*#"-)25*41-3,1..8351.0&59276(-7:49:>;>9876=7?6-1==>>>5=87990=&:8>060?6:888?;&74667*>?67?=B8?@@?;<=8749:7,0:=?=<<=)@A5?=:,;;53-7-=?;>=1<>?:5-86><48/?9;;;.*709;504/7:78<.=0?999>@4>47?>>95@98;6928:=7:0=3=6218?,7??4/<@;@84<74>B46@3CA37AAA>:<@>=&:=A3=:<79>:2A42><<7357*;/4=:<(8<68785572?<6<968)%..86829%7?B0@8@9&395;;@AA297)<5*-%*<7<>?8<110':?*/,=:;:::/713.-785+B@:AA=@5:)90;;';A7@@2@;:B;;9@96:0:198,/-3;<=&>;5940';=5@5>8>975?98>><3*=7<@/7:67%<8<9668-5B:>9A<===;99826?699<:/>A1@78;0BA@;>9=<*-5<5>7:::4-=.84<:>89:184B2;1:<60;5;?6899@:260=2:;>29>687;=06$22/::)<>9.@7:555;?3?=9<2B?=0?B:4)&669775%3406;;>@>3<953<%A?::B<@>9@=>(8=78?9>-:;68);6,4161<379@24?4=>592+4?;=C=39<9;A::7=8<>==(>8>B=<:>1=B=>5091532<575708B64=79:8>27,6334&518;8=6>::8=98;8776,527-8=:;/8069;:7>51111255;,3:7==5.418098..2+347985):,56<:34./1/:89472697<:/33770,+5$*)=:==9=;=8:6;7(:54673:997;92+8/446)3+19,899/9::;617669+60(22/94086:7702.61,6615531747115-93.2:+6527:63/:962/78839567--:693-)-868::6530-13(+2+)3735/4,29467&33556-2*73,.665+893:78698:/;617/5,35:7::593635,746360:914;767.496849463/3758368545413'4778146'424:4561-0(36651574:77/11923.48.;7764::65;1969432;485(2/358394957323:8731+%++18:25%6:::769645(,18(,342.,.14420%)25013830..7818540433/836+,)*86//5::74546/0/45555)3661:4)'&',3(4577001/286(510-,.+'/973157509;5-)/.05824.5.735:8:53543.-95//16:65(4..52-3,1+43-4.60/51616,4+022,79:03)1(%3+/&28+0847(66268611%1.+53.*26957,5122//03+6933675%5+918,66'907258&*..+)*&9365490(9777&678,3:99++1,/85&865421.1*99067:89*54,$3537361/54.5.5::26483.4(/0:/8918371+33(,014),3%*)850614869747091-..1(-692897:38:8:33/44,8)504)8413:15-00%)'.*+-1&053&5.55853+7-/566766:885684117754168317--:7967228779:3.37555/465948/1527&*6)6421*.5:631,3743579919394.1:477,3553+'1*0163650832+429:60396934$*38+/72617559) @rCer/2247/2177_48_CCS GGAGAGAAAATGGCGTCCACGGATTACAGTACTATAGCAAGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCACCCACTCAAGATATGCACAGACCACCCAGCATATGGCAACAAAGCTATGGAACCTATGGACAGCCCACGATGTCAGCTATACCAGGCTCAGACCACTGCAACGATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGTATAAGGACCATAAGTATACTACTCCAACTGCCCCCAGGCATACAGCAGCCGTCCAGGGTATGCATGTGCTTATGATACCAACCACTGCTACAGTCACCACCACCCAGCCTCCTATGCAGCTCAGTCGCAATGGCACTCAGCTGCTATCCAGCCTATGGCGCAGCAGCAGCACTGCACCTACAAGACACAGATGGAAACAAGCCATGAGACAGTCACTCAGTCTAGCACAGGGTTACAACCAGCCCAGCTAGGATAGGACAGAGTAACTACAGTTATCCCAGTACTGGAGCTACCCATGCACCAGTCACCGACTCCACTTACCTCTACCAGCTATTCTCTCACAGCCGACAGTTAATCAAGCATTCTTCACAGAAACCTATGCAACCGAGCAGCTATGGACAGCAGAGACTATGCAACAAAGCACATGGCAGCAGCCTCCACTAGTACCACCCCAAACTGAACTACAGTCAAGCTCCAATCAATATAGCCAACAGAGCACAGCTACGGCACAGAGTTCATTCGACAGGACCACCCAGTAGCATGGGTGTTATGGCAGGAGTCGGAGATTTCCGGACAGAGAACCGGAGCATGATGGCCTGATAACCGGCAGGGAAGAGGATTGATCGTGAGGCATGAGCAGAGTGGCGGGAGGAGGCGCGGTGGAATGCAGCGCTGGAGAGCGAGTGCTCAATAAGCCTGGGACCATGATGAAGACCAGTCTGTCTAGGCCACCTGTAGATCCAGATGAAGACTCTGACAAACGTGCAATTATGACAAGGATAAATGACAATGTGCTCTATGATCTGGCAGACTTCTTAAGCAAGTGGGTTGTTAAGATAACAAGAGAACTGGGCAACCATGACCACACTACCTGGACAAGGAAACAGAAAGCCCAAGGCGATGCCAACAGTGTCCTATGAAGACCCACCTACGGCCAAGGCTGCCGTGATGGTTGACGGGAAAGATTTCAAGGAGCAAACTAAAGTCTCTCTTGCTCGGAAGAAGCCTCAATGAACAGTATGAGGGGGGTATGCCACCCGTGAGGCAGAGGATGCCACCACACTCCGCGGAGGTCAGGAGCCCAGGAGGTCCTGGGGACCCATGGGTCGCATGGGAGGCCGTGAGGAGATAGAGGAGCTTCCTCCAAGAGGACCCCGGTTCCCGAGGGAACCCTCCGGAGAGGAAACGTCCAGCACCGAGCTGGGACTGGCAGTGTCCATCCGGTTGTGGAAACCAGAACTTCGCCTGGAGAACAGAGTGCAACCAGTGTAAGGCCCAAAGCCTGAAGGCTTCTCCCGCCACCTTCCCGCCCGGTGGTGATCGTGAGAGGTGCCCTGTGCATGCGGGAGGAAGAGTGCCTCATGATCGTGGTGGTCCGGTGAATGTTCAGGGTGGCCGTGTGGAGACAGAGTGTTCGTGGTGGCCGGGGCATGGACCGAGGTGCTTGTGGAGGAAGACGAGTGCCCTGGAGGCCCCTGACCTTTGATGGAACAGATGGAGAAGAAGAGGAGACGTGGAGACTGAAAAATGATAAAGGCGAGCACCGTCAGGAGCGCAGAGATCGCCCTACTAGATGCAGAGACCCGCAGAGCTGCATTGACTACAGATTTATTTTTAAACCAGAAAATGTTTTAAATTATAATTCCATATTATAATGTTGCCACAACATTATGATTATTCTTGTCTGTACTTTAGTATTTTTCACCATTTGTGAAGAAACATTAAAACAGTTAAATGGTAGTGTGCGGAGTTTTTTTTTCCTTCTTTAAAATGGTTGTTTAACTAAGACTTTAACAATGGAACCCTTGTGAGCATGCTCAGTATCATTGTGGAGAACAAGAGGGCCTCTAACGTACAATGTTCATGGTTGTGATGTTTTTTTTTTTTTTAATAATTCAAATGTTT 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@rCer/2249/25_2185_CCS ATGGGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCGGTGGATGCCGTGGTGGAGTGCAACTCGAAATTGGACCCCACAAAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGTCTCCCACAGATCTCCCAGCCAGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCATACCAGCGAGGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCCCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCCGCCGGTAACAACGCTGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCCGCCACCCCCAGACTCTGATCTCTGTAGCGGCCCCCTCCTCCCCAGCCCCTTTACGCCCCCTGCCTGCCACACTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGGGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCAGTGGACCAAAGGAAGGAAGCAAGCATCTCTGCATTCGCATCCTCTTCTATTAACCAGTGGTGAGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAAACTGCCAAAAACAAGACACGTAGCAGCGCACACTTCACAAAAGCCAAGCCTAGGCTGCCCTGAGCATCCTGGTTCAAACAGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAACTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTCGGGAGGGGGGTAACAGTGACGTGCAGGGACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTTATGTTGAGGCTAGAGGCATTTGGAACAACCAATCTATGTAGTTAACTTGAAGAAACAGATTTTTTAAATGTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAAACATCCTCTTAATGTGCAGCAAAAGCAGGCAACAAAATCTCCTGGCTTTACAGACAAAAATGTTTCAGCAAACGTTGCACATCATGGTTTTTGAAGGCTTTAGTTCTGCTTGCTGCCTCTTCTCCACAGCCCAACTTCCCACCCCGATACGTGAGCGAGTGATGATTCTTGTTCAGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTGGAATGGAGGGAAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTTCAGAGGCCGGGGTAGAAGCACTGGGGTGGGGGCGGAATTGGGGTTACTCAATGTAAGGGATTCCTTGTGGTTGTGTTGGGATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGGTTACATCCAGTTTTCAATCTTCGACAGCTGGGCTAGAACGTGAACTCAGTAGCTGAACCTACCTGACCGAGTCACGTTCTTGGATCCTCAGAACTCTTTACTCTTGTGGGGGTGGGGGTGGGAACTCATGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACGCATTCCATGGGACTTTCCTTCCCTCTTCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCAGCCAGCGCGGCTGCCAGGCTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACAGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAACATTGTAAGTCAGCCACTGGGGCCCGAGGATTTCTGGGACCCCGCGGTTGGGAGAAGGGAGTAGTCCGGCCTTCCAGGTGGCATGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGCGCAGAAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACAGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTTCTTAATGAGATATTTGTATTTATTTCCAGACCAATAAATTTGTAACTT 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rCer/2250/0_1889_CCS ACCCTGATAACCTATTGAGCATGGCATTGTCACCAATGGACGACAGGAGAAAATCTGGCACCATACTTTCTACAATGAGCTGCGCGTGGCCCAGAGAGCACCGGTGCTGCTGACGAGGCATCCTCTGAACCCTAAGGCAACAGAGGAAGATGACTCAGGTGAGGCTCGGCTGACGCCGCGCTCCCGTCGTTTCCCTTGTCATTTTTTGCCAGCTTGATTTCTGACATTTAAGTGTTCTTTCGCTGTTCCAGGCTCTGTCCTCTCCCGGCATTTCCTCCTGAAGTCTCCAGGTTTCTCATTGGTTCTGCCTGCGTTCTTTTCTTTTCTTCACACATCACACTGGCATGCGGCATGTTGTGGCGTGTGAGCATGGGGTGGCCGTGGTCTCTGTCCTTGACTAAGCCGCTCCTTGTTCCTCCTCAAATTATGTTTGAGACCTTCAACACCCCGGCCATGTACGTGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGCGACGGGTCACCCACACGGTGCCATTCTACGAGGGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGTGGCTACAGCTTCACCACCACGGCCGAGCGGAAATTGTGCGCGACATCAAGGAGAAGCTGTGCTATGTCGCCCTGGACTTCGAGCAGGAGATGGCCACCGCGCATCCTCCTCTTCCCTGGAGAAGAGCTACGAGCTGCCTGATGGCCAGGTCATCACCATCGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCCTCTTTCTGGGCATGGAATCTTGTGGCATCCATGAGACCACCTTCAATTCCATCATGAAGTGTGACGTGGACATCCGCAAAAGACCTGTATGCCAACACGGTGCTGTCTGGTGGCACCACCATGTACCCAGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTGGCACCCAGCACCATGAAGATCAAGATCATCGCACCCCAGAGCGCAAGTACTCAGTGTGGATCGGTGGCTCCATCTTGGCCTCACTGTCCACTTCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCCTCCATCGTCCATCGCAAATGCTTCTAAATGACTGAGCAGATGCGTAGCATTTGCTGCATGGGTTAATTCAGAAAGTATAATTTGCCCTTGGCAAATGCATACACCTCATGCTAGCCTCACGAAACTGGAATAAGCCTTTGAAAAGAAATTGTCCTTGAAGCTTGTATCTGATATAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACGTGTATTCAAGTTAACTGTTCCCTTGGTGTTTGTTTAATACCCTGTACATATCTTTGAGTTCAACTTAGTACATGTGGCTTTGGTCGTTTCGTGGCTGAGGTCAGAACGTGCTTGTGGAAGACAAGTCTGGCTTGGTGAGTCTGCATGGCCAGCAGTCTCCGATCTGTGCAGGGTATTCATGTGTCAGGGCTTGAGTGTTCTGGGATTTCTCTAGAGGCTGGCAAGGGCTCTGAACCAGTTTCTGCCCTGCCAGTCTGTCAGGGTTGGAAAGTCCAAGCCATAGGACCCAGTTTTCTTAGCTGACGTTTCTGCCAGAACACCGTGGGCTGTTACTTGCCTTGAGTTGGAAGCGGTTTGCATTTACACCTGTAAATGTATTCATCCTTTTAATTTATGGTAAGGTTTTTTTTGTACGCAATTCTCAATTCTTTAAAGAGATGACAACAAATTTTGGTTTTCTACTGTTATGTGAGACATTAGGCCCCAGCAACACGTCATTGTGTAGGAAAATAAAAGTGCTGCCGT 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EKK?KKGKKKJKKKJKKAKEKKJJKAJ=;KGIK@KBKHKKKKIKFK4KGKJKKGKJKK@KKKDKKK4KKKKKKKE:KKK@&FFKCA$KKKKKKKKIKF0KKGKKKKCKJ%K-BKKKKJKKHKKKKKK=K0KJKKKKKKKKKKAK@KIKKJKKKKJJK-KKKJ9KKKKKKGKKIKJKKHKAKKKKKJJ:KKJKIKKKIKKKKKGKJ'KKKKKKKIKKKHIKKBKIK8KKKKKHFDJFKKG@KKHKKKJGKJKEJ0KKEKK5KK8FKI(KHEKCKK%KKHIKKD?H&KKKKC:KKKHKKKKKKK@3KJKKIJKCKKKKKKKIKKIKKIKHIDKJIKK0KKKHJKDBB-?K @rCer/2262/25_2834_CCS ATGGGGCACGGCTTCCGGTGGCGGGACGCGGGGCCGCGCACGCGGGAAAAGCTTCCCCGGTGTCCCCCCCATCCCCCGCCCCCCCGCGTCCCCCCAGCGCGCCCACCTCCTGCGCCGGGGCCCTCGCGAGGCTGCAGCCTGAGGAGATTCCCAACCTGCTGAGCATCCGCCCACCCACTCAGGAGTTGGGGCCCAGCCCCCAGTTTACTCGGTTTCCCTTGTGCAGCCTGGGGCTCTGCCCAGGCCACCACAGGCAGGGGTCGACATGGCAGAGACACTGGAGTTCAACGACATCTATCAGGAGGTGAAAGGCTCCATGAATGATGGTCGACTGAGGTTGAGCCGCCAGGGCATCATCTTCAAGAACAGCAAGACGGGGAAAGTGGACAACATCCAGGCTGGGGAGTTAACAGAAGGCATCTGGCGCCGTGTTGCTCTGGGCCATGGACTTAAACTGCTTACAAAGAATGGCCATGTCTACAAGTATGATGGCTTCCGAGAATCGGAGTTTGAGAAACTCTCTGATTTCTTCAAAACTCACTATCGCCTTGAGCTAATGGAGAAGGACCTTTGTGTGAAGGGCTGGAACTGGGGGACAGTGAAATTTGGTGGGCAGCTGCTTTCCTTTGACATTGGTGACCAGCCAGTCTTTGAGATACCCCTCAGCAATGTGTCCCAGTGCACCACTGGCAAGAATGAGGTGACACTGGAATTCCACCAAAACGATGACGCAGAGGTGTCTCTCATGGAGGTCCGCTTTTATGTCCCTCCCACCCAGGAGGATGGTGTGGACCCTGTTGAGGCCTTTGCCCAGAATGTGTTGTCGAAGGCGGATGTAATCCAGGCCACGGGAGATGCCATCTGCATCTTCCGGGAGCTGCAGTGTCTGACTCCTCGAGGGCGTTACGACATTCGGATCTACCCCACCTTTCTGCACCTGCATGGCAAGACCTTTGACTACAAGATCCCCTATACCACAGTGCTGCGTCTGTTTTTGTTACCCCACAAGGACCAGCGACAGATGTTCTTTGTGATCAGCCTGGACCCCCCAATCAAGCAAGGCCAAACTCGCTACCACTTCCTGATCCTCCTCTTCTCCAAGGACGAGGACATTTCGTTGACTCTGAACATGAACGAGGAAGAAGTGGAGAAGCGCTTCGAGGGTCGTCTCACCAAGAACATGTCAGGATCCCTCTATGAGATGGTCAGCCGGGTCATGAAAGCGCTGGTGAACCGCAAGATCACAGTGCCAGGCAACTTCCAAGGGCACTCAGGGGCACAGTGCATTACCTGTTCCTACAAGGCGAGCTCAGGACTGCTCTACCCGCTGGAGCGGGGCTTCATCTACGTCCACAAGCCACCTGTACACATCCGCTTCGACGAGATCTCCTTTGTCAACTTTGCTCGTGGCACCACTACAACTCGTTCCTTTGACTTTGAAATTGAGACCAAGCAGGGCACTCAGTATACCTTCAGCAGCATTGAGAGGGAGGAGTATGGGAAACTGTTTGATTTTGTCAACGCGAAAAAACTCAACATCAAAAACCGAGGATTGAAAGAGGGCATGAACCCAAGCTACGACGAATATGCCGACTCTGATGAGGACCAGCATGATGCCTACTTGGAGAGGATGAAGGAGGAAGGCAAGATCCGGGAGGAGAATGCCAATGACAGCAGCGATGACTCGGGAGAAGAAACCGATGAGTCATTCAACCCAGGTGAAGAGGAGGAAGATGTGGCAGAGGAGTTTGACAGCAATGCCTCTGCCAGCTCCTCCAGTAATGAGGGTGACAGTGACCGGGATGAGAAGAAGCGGAAACAGCTCAAAAAGGCCAAGATGGCCAAGGACCGCAAGAGCCGCAAGAAGCCTGTGGAGGTGAAGAAGGGCAAAGACCCCAATGCCCCCAAGAGGCCCATGTCTGCGTACATGCTGTGGCTCAATGCCAGCCGAGAGAAGATCAAGTCAGACCATCCTGGCATCAGCATCACAGATCTTTCCAAGAAGGCAGGCGAGATCTGGAAGGGAATGTCCAAAGAGAAGAAAGAGGAGTGGGATCGCAAGGCTGAGGATGCCAGGAGGGAATATGAAAAAGCCATGAAAGAATATGAAGGGGGCCGAGGCGAGTCTTCTAAGAGGGACAAGTCAAAGAAGAAGAAGAAAGTAAAGGTAAAGATGGAAAAGAAATCCACACCCTCTAGGGGCTCATCATCCAAGTCATCCTCAAGGCAGCTAAGCGAGAGCTTCAAGAGCAAAGAGTTTGTGTCTAGTGATGAGAGCTCTTCGGGAGAGAACAAGAGCAAAAAGAAGAGGAGGAGGAGCGAGGACTCTGAAGAAGAAGAACTAGCCAGTACTCCCCCCAGCTCAGAAGACTCAGCGTCAGGATCCGATGAGTAGAAATGGAGGAAGGTTCTCTTTGCGCTTGCCTTCTCACACCCCCAGACTCCCCACATTTTGGTACCAGTTTCTCCTCATGAAATGTAGTCCCTGGATTCTGTGCCATCTGAACATGCTCTCCTGCTGGTGTGTATGTCACTAGGGCCGTGGGGAGACTTCTTAACTCTGTTGCTTCCCAAGGATGGCTGTTTATAATTTGGGGAGAGAGAGGGTGGGAGGCAGGGCAATGCAGGATCAAAATCCTCATCTTACTTTCCCGACCTTAATTAAGGATGTAGCTGCTGCTGGTCCTGTTCAAGTTGCTGGAGCAGGGGTCATGTGAGGCCAGGCCTGTAGCTCCTACCTGGGGCCTATTTCTACTTTTATTTTGTATTTCTGGTCTGTGAAAATGATTTAATAAAGGGAACTGACTTT 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AB-CCAA=@@C==ABCBCB>BB?ACBCC@0@;?4B@BB?>BCB:A=C@@?0@C?A?@;@5BC@>>/@=;;;>@;A>(AAAA?@??>?@)@@>BBABB@B?CAA/?AA1CCACACB8?A;?8@7A=C6=@>AAA@AC>CC.B@A>9B>>=>=B==A;@8CC@4<8;<1A???@A?CCAA/@A>,@=7AC3>AB8BBA3BB;BABB@3;2<;8/=<>AB=@B?A>>CAB3>=0=?;88B?A;@@>>>B8>?A99??@ACA;;?CA-@@6>:5=?.@=;BBB@>=A@846>@B6@B>?5ABBC??<>@.?>CC?:?2><<@:8>?@>AA6?>?=@A>A7>:CAB??>>C;B5:=?AB.@BCBA7@@6>CC?3A??1=2A??@>@AA8=,3@C9;=A?BC=A>A>AA<>?=9AC=A>=,?BB<6>@?>>;CB?@A:6>>2?=:=;;96<3=4?BCACB0?AA=ABAAA=BB<:??9828A=?@B:?:AAC@BA6@ABACA@69@:?:ABACCCB0A=AB?ACA>=@C?9BA@;A?A91?=49@CACA??B>A>@=ACB>B:A6B=@9?B:/<:A?>??C:>>B?-=7>>ACC>=;?B39?:?7:==?@;>;@C=<5:=CB;=A>A=CC>C3@B@5=B;AB?A=BCA=A@1;=?;?>6AA@C?/>;:9:>><:.B@0A@@@=>B5AAC?A?>@=@BC@CA7@C6@@A?==?6B>A@C5=AA*?>AB;@<=?)>=>>7A>;C;A>BB@=7?B;:;;@3@;?><8><163;>@?A5C::?>AAA<;>A>AA'@>?C>?CAAACA<:BA9?=4;?C@>>@AC?C;AC8B6BABBCC@<;>?;:9>?B,AAC?AA;=>?A9?>CACB?A>ABA>A=AB::=A>?<(8<<@CA=:>@CCAACA827BABABA@:=:;=;BB7>@>BB7<;?A@9=>?;AA?B=A>6?5?<,=A;ABAA9B7>?C:BA=CA?;ACA91<:;;;>;;A7)8;@?B:>;?AAAAAC@6@CB?BB>;:@A;6/=@?B7;C@6:9@A@<:B@;@A=>A=A=><@BBA==>>@AC<7BBA>BCCB@C?A>:<@C<:@A?;>@3>9>AB9A>C=>A5@?>BB<:8?5@BA@==@:B@B@@CB6BBACBA>/<;5@:A7=A?:A>B>CCBB>7?CAACCA?AC=:@-@A==<;686=38983=<<=;==>>8?=7=;;<=+<97=:=;<785<:6::8.;6?:<:?::=6>>>9=7;<*5=>371;>8?=>=2;94=8867?8>7:?>?7=43:89=><8=8;67075<9?<;::9819<<8(88>;68=>==:??;<9;20>=<=::;;>992=>?:2:7:?>:=6<8=:7;8;<=:=<:==15>79;57=7<5>=<29<==:?:999<899=?=>:>>>>8;:;>4:==07=9<=9=>?=??:49>>=?<9<=;9=;:;==>4>>1<===:99>9=<:7==9>>?<89=?:=;=9:==?>6:?>9===?7>::?>>===0:9?:;+<<;<==90=<8<9<<>3<+;;3<>:=::6=6=;=>9;<=:8=;57=??>>==>6<=>4<>8==:;>;?99>>9>:=9=7=95><>=<+;6*8>>=><>;>;998>:<<3>==3=<>/>=1=6929?=??:9=9<;8<==:=?:>9-99=<>>79=:627;>>?=?>8;5=?=8=>2;-6::.=<>=;:=7:<9??:5>;=:>2<-:<;>9=;9:=9;>756::<68>=788<>:%8=999?=<7=77=38:=<:/;>17=6<>9<7;9;?=2;?850.75;=:=6???><:99::=2=8;;578<*;=85<8=;=>>>13&:>><9>82960=<<9==?=<=;.==5-<9248>9;8<><><>;=:1=51;<;887(:84==7=32;<==<:=<>9=;38<>?=>>?>7>79=73<8=7>?:4:93=;9;<5<>>;=76(<===<:<9=;:<4=<=<.=9==9-=><;>>;?=>?>9=:;:78;:=9>/737715:7/65=??=>.:<:>;939?8?=;875=5?===<:-:>>=9=4;?><2;?<83=9<:9:=??9><7>>>=?:=;<3<<>>:7:=>:89:8=<:>9;==93969=:=68>>>9==:397;40);<9?9;7???;;=98<;,<1:::=7;6=8:=?2?<2<26<-==.793317>>=;2:<67==6,;:>5=>4298<;;><:7;';<<;>?<<>2;;=*3*7<7=?>94957==4:<:=<7999==?86>;9/<=:>=>?>>;:?89=:4===85:;:?>?=?7?<9?2=6;;=<877>><<=63=;>5:8<9>:730=0=?>56:??;;829>:=2;:<>>>8*<<;=>?=;?3>93==9?:3=89>>>:?? @rCer/2264/2399_59_CCS ATGAGGCACCCCCTGTAAGCGGTTCACGATGCCGGGGCCACGTGAACCCTGCCCCTGCCGGAATACGCTCCGCTCCGGACCAGCTCAGCCTGTGATACGCTGGACTCCGCGCGCCCGCAGCACGCAGCCGAGGAGTCAAGAGAGCCGCAAGCGCGGGGAAGGCTCCCCGCACAGGTCGGGAAACCGGCCGTGCAGCGTGGGGGACACTCACTCGGGCTGGCACTGGCTGCTAGGGTGTCGTCCTGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGGCTGGTTGTGGGTTTCTGGAGGGCCGCTCTCGCTTGTCCCACGTCCTGCAAATGCAGTGCCTCTCGGATCTGGTGCACGACCCTTCTTGGCATCGTGGCATTCCAAGGTTGGACCTAACAGTGTAGATCCTGAGAACATCACCGAAATTTTCATCGCAAATCAAAAAGGTTAGAATCATCAACGGATGATGTTGAAGCTTACGTGGGATGAGAAATCTGACAATTGTGGATTCTGGATAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGACATCAATTTTACCCGAAACAAGTTGCGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTGTCTGAACTGATCCTGGTAGGCATCCATTTACATTGCTCCTGTGACATTATGTGGATCAAGACTCTCCAAGAGGCTAATCCAGTCCAGACACTCAGGATTGTACTGCCTGAATGAAAGCAGCAAGAATATCCCCTGGCAAACCTGCAGATACCCATTGTGGTTTACCATCTGCAAATTTGCCGCCTAACCTCACTGTGGAGGAAGGAAGTCTATCACGTTATCCTGTCGTGTGCAGGCGATCCGGTTCCTAATATGTATTGGGATGTTGGTATCTGGTTTCCAAACAATGATGAAACAGCCACACCGAGGCTCCTTAAGGAATAAACATTTCATCTGATGACAGTGGGAAGCAATCTTTGTGTGGCAGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCACCTCACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAGTACCACGGCTGCTCCAGTTGGATATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATAGAAACAGATTTCTGCTCACTTCAGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGAACTGCAGCGAATGACATCGGGACACCACAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACGGTCGGGAACATCTCTCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAGTTTGGCATGAAAGGTTTGTTTGTTTCATAAGATCCACTGGAATGGTAGCTGAAATAAAGGAAAAGACAGAGAAAGGGGCTGTGGTGCTTGTTGGTTGATGCTGCCCTGTAAGCTGGACTCTTGGGACTGCTGTTGGCTATCCCGGAAGTGCTGCTTATCTGGGGTTTCTGGTAGATGTGGAGGTGTTTGAGGATGTACTATGTGAGCCTGCATATATTGTGAGCTGTGATTGGGGAACACCAATGCAGAGGCAACTCTCAGGCAGCTAGCAGCACCTCAAGAAAACATGTTAATTAATGCTTCTCTTCTTAACAGTAGTTCAAATACAAAACTGAAATGAAATCCCATTGGATTGTACTTCTCTTCTGAAAAGTGTGTTTGTTGACCCTACTTGACATTATTGACTTATTGCTTCTGTTTATTAAATTTTTTGACCTGCAAAATTAAAAAAAAAATTAAAGTTGGGAACAGGTATAAGTGCACACTATAGTCTAATCTACATGTAACACATATTTTAGTACGTTTTCTATAATCAGCACTGAATTCAGAGGGTTTGACTTTTTCGTGTATAACACAGTGACTTAAAGAGTTAAGGTGTAATAACCTCACTCTGGGAGTGGGAGTGTTATTAAAAGGTTATTTCCTTCACTGTCAGTAAAAGTCCAAATGTTTAGCTTAAGTCTGAGAGTCAAACAGTGTTAAGGATTGCCTTAAAGTTCCTTAGCCAGCAAAACAAAACAAACAAACATTTAAACATTTAAAAG 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@rCer/2267/1645_52_CCS AGCGTGATAACGCAGAGTACATGGGACGCGCGGCGCGGCGCGCTTGGCGGCCGGAGCTAAGCGGCGCTGAGCTAGTCTGAGCAGAGCCGGCGAGTGCGCGCGGGGCCTACAGGACGCGCAGGTGGCGGGTTGTCGACATGTCGCACGGTCACAGCCACGGCGGGGCGGCTGCCGCTGCGCCGCCGAACGGGAGGAGCCGCCGAGCAGCGCGGCCTGGCCTATGGCCTGTACCTGCGCATCGACCTGGAGCGGCTGCAGTGCCTTAACGAGAGCCGCGAGGGCAGCGGCCGCGCGTCTTCAAGCCGTGGGAGGAGCGGACCGACGCTCCAAGTTTGTTGAAAGTGATGCAGATGAAGAGCTTCTGTTTAATATTCCATTTACGGGCAATGTCAAGCTCAAAGCATCATTATAATGGGAGAGACGATGACTCACACCCTCTGAATGAGACGTACAGAATATTCCACAGATGTCCTTTATGATACAGAAAGGGAGCCAGATCAGACCTTTAGTCTGAATCGGATCTTACAGGAGAATTAGAGTATGCTACAAAAATTTCTCGTTTTTCAAATGTCTATCATCTCTCAATTCATATTTCAAAAAACTTCGGAGCAGATACGACAAAGGTCTTTTATATTGGCCTGAGAGGAGAGTGGACTGAGCTTCGCCGACACGAGGTGACCATCTGCAATTACGAAGCATCTGCCAACCAGCAGACCATAGGGTCCATCAGGTTACCCCACAGACACACTTTATTTCCTAAGGCTGGCCAAGGCTCCCATAGAGGTGCTGTGTCAGTGAAGATGTATGACTACCTGTTGGGAAGGACAAAGGGATGAGGCTCCACAGAGAGTTGGCTGCCACAGCCTCTGCCAAGCTTTGTCTTTGGGCTTGCTGCAGAAACCTGGACTACGGAAGATACGATACCACTGGAGGGTTGTGTAGGTGCCAGGGACCATCGTTGTTCTCTAGGGCGCTGTGGAAATTGGGTCTTGGCTGGTAGCATCTGGCAGTCATGGATAACGTTTGCTTTCCAGTCAATGTGGCCATGTGATTCCAAGTGTCATGTTGCTTTGTGGCAGGATTGTTGTGTGACTTGTTTTTTGTTTTTTTTGTTTTTTAAAGGAAACTTTGTGGGTTATAGAAAACTTTCTGACGCCTCAGGATTGTGTTAATAGTAGCCATCAGGAGGTCTCCAATTAAAACACTTGTTCCTGCTTGCTCCTTTCCCCTCTCATTGTTCAGCATTCTTGTCAAGTTGCCCAGCTTGGAGTTGTCTGTCACGCACATGTGTCCTGTGGTTATAGCTAGAAGATCAGGAGTCTCCTGCTGATGCGTGATAGCTTAAGCTTGGGGAGAAGGTCTTTTCCACTGCCTAGCTAAGCAGTCTGGGGAGAGCATGGGATCATTTCTGTGTGTGTGGGTAATCTGGTCGGTAAGATTGAGACTTAGTTAAGATTTCCCTTGGAACTTCCTTAATGTTTATTAGCTTCTAACTAGTGTTGTAAGTCCAATGCCAGAATTTGGAATCTGAGTTCTTCTTTTCATGGCTTTTATTCACTGTGACTAATAAGCTTCTAATAAATCTTGCCAGAC 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@rCer/2268/1824_62_CCS ATGGGTGTACCCCTAACCCCTGTGAGCATGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAGGGCTGGCAAGGCCCACGATGCCAGCAGGATGTGGACGAGTGTGCTGGCCCCGCACCCTGTGGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGCACCTGCCATGGAGGGTACACTGGCCCTTCCTGCGATCAGGACATCAATGACTGTGACCCCAACCCATGCCTGAACGGTGGCTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTGCCTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGACGTGGACGAGTGCCTGAGCAACCCCTGCGGCCCGGGCACCTGCACCGACCACGTGGCTTCCTTCACCTGCACCTGCCCGCCGGGCTACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCAGCCCCAGCTCCTGTTTCAATGGCGGCACCTGCGTGGACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAACATGAGGCAGACCCTTGCCTCTCGCGGCCCTGCCTACACGGGGGCGTCTGCAGCGCCGCCCACCCTGGTTTCCGCTGCACCTGCCCCCAGAGCTTCACGGGCCCGCAGTGCCAGACGCTGGTGGATTGGTGCAGCCGCCAGCCTTGTCAAAACGGGGGTCGCTGCGTCCAGACTGGGGCCTATTGCCTTTGTCCCCCGGGATGGAGCGGACGTCTCTGTGACATCCGAAGCCTGCCCTGCAGGGAGGCTGCAGCCCAGATCGGGGTGCGGCTGGAGCAGCTGTGTCAGGCGGGTGGGCAGTGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGGCCGTACTGGTAGCCACTGTGAGCAGGAAGTGGACCCTTGCTTGGCCCAGCCCTGCCAGCATGGGGGACGTGCCGTGGCTATATGGGGGGCTACATGTGTGAGTGTCTTCCTGGCTACAATGGTGAGAACTGTGAGGACGACATGGACGAATGTGCCTCCCAGCCCTGCCAGCATGGGGGTTCATGCATTGACCTCGTGGCCCGCTATCTCTGCTCCTGTCCCCCGGGAACGCTGGGCGTGCTCTGCGAGATTAATGAGGATGACTGTGGCCCAGGCCCACCCTTGGACTCAGGGCCCCGGTGCCTACACAATGGCACCTAGCGAGAAACCACTTTTAGAACTATGAGTACTACTTTTGTTAAATGTGAAAAACCCTCACAGAAAGTCATCGAGGCAAAAAGAGGCCGGCAATCGAGTCTCCCTGTTGACAGTAAAGTTGAAATGGTGACGTCCACTGCTGGCTTTATTGAACAGCTAATAAAGATTTATTTATTGTAATACCTCACAGACATTGTACCATATCCATGCACATTTAGTCACCTGCCTGTGGCCGGTAAGGTAATGTCATGATTCATCCTCTCTTCAGTGAGACTGAGTCTGATGTGTTAACGAATAGGTGAAGAAAGTCTTGTGCTGTATTCCTAATCAAAAGACTTAATATATTGAAATAACACTTTTTTAGTAAGCAAGATACCTTTTTATTTCAGTTCACAGAATGGAATTTTTTTGTTTCATGTCTCAGATTTATTTTGTATTTCTTTTTTAACACCCTACATTTCCCTTGTGTTTTTTAACTCATGCACATGTGCTCTTTGTACAGTTTTAAAAAGTGTAATAAAATCCAACGTGTCAATGT 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:<=;3;:>>?;:2:;%;<=7<>:>>>=7:87:%78?;<9<=:=857*>>9==<9;>=:8<=?9:>;<9;7><:99=;::+7=?27;;>><9?7?=5=9>?:<=7<:>=7:4:;9<;59>>;9<74:<4+;==-<9=:=4=<>=39>29;>=:=8=<6;<<5-97<=/789;:>=9>4;>?:98<2;6>3>==,8:979:7:5?=4>>>>;79756==>::916450;473;8;5:;:<27;6;-539/>=<=<*96<76<;982<==><=><;<6:991599,894;;=?<7<;97==86<==;169?9>;>>97:9<;>=:=78:6:7465378669::9:522488933445:76549489;3620-4:8696644/8354..)2-630&0-4348/4;078:40993390885:975;59738051-645775.:33648.34+:7:9::5:89:7252997:879898589289255416659898877/79989595829:6:3734483:6:968478.:5/7/169:99::;98486792;68378/4/3669985;5::18914362,2/+468.9677896:9/4476667245*3)62927567:8636/7763224.82858745,285/78/749740572::::25;78844::667687'97;9:::253469:5792885:759818798:3986:7987175456888::275566+87376-497995)29288;8058:6.875776:957587843:8039.-256.:99769-9825,/9::9997::989:638467'26969785(*1678:99.0768.99626-8:8::89:867941983:68:806:5070/*5::6764286246(83:35926864/959485897575:3:5-5:3/672318.625,7603647/84:5:6:851877&698:75+:65+07898:89889*64/8.329::::689:3:2;8:;7::5,9)68728:8;95.7:::566:73763745:::5514-76638246772158.555145-+/.334:867/921)75:674;9;98::66:987:764948979962/7:05./515:72-1103772:8:9:7813737:99:9316466;9;29850,5)7::17178485448;6456&70777696:8:;7395083*+5348:9:7-8719858,48985:8576494899:9;;3:96772865887:9%/:/681256664366515045-55666.341.614162/4646045144156654/044354146466624563.15455315646465566/+6/16,510355010204144000/,13*433'545-031)-*0345451/2--30250+*4436566222544655460464615353/3(21,6366363/22656466444634,.5431/54/05/26362665.43164.34-033/5664656.4336434421402413563302543//)15552/,124.0362./)/3//5565/54542/4656633524442).42%2145-532+55236564420446(5655525045342436510444-565663555535(50)-1020+0/62-5656544055253,64346561)3043513565441/2-032435*5660035633-3323/451/-36546441436 @rCer/2271/25_2033_CCS ATGGGTGGCGTGAGCGGGACGTGAGCTGAGGCAGGAAGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTGCGGCGCATCAGCGAGGAGGAGGCGGCGCAGTATGACCGGCAGATCCGCTGTGGGGACTGGAGCCAGAAACGGCTGCGGGCCTCCCGGGTGCTTCTTGTCGGCATGAAAGGACTTGGGCTGAAATTGCCAAGAATCTCATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTATCTCCCGAAGATCCTGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTTGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAATTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGATACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAGAAGGTGGTCTTCTGTCCTGTTAAAGAAGCCTGGAGGTGGACTGGAGCAGTGAGAAAGCAAAGGCTGCTCTGAAGCGCACAACCTCCGACTACTTTCTCCTTCAAGTGCTCCTAAAGTTCCGTACAGATAAAGGAAGAGATCCCAGTTCTGATACATATGAGGAAGATTCCGAGTTGTTGCTCCAGATACGAAATGATGTGCTTGACTCACTGGTATTAGTCCTGACCTGCTTCCTGAGGACTTTGTCAGTTACTGCTTCTCCGAGATGGCCCCAGTGTGTGCAGTGGTTGGAGGGATTTTGGCACAGGAAATTGTGAAGGCCCTGTCTCAGCGGACCCTCCTCACAACAACTTCTTCTTCTTCGATGGCATGAAGGGAATGGGATTGTAGAGTGCCTTGGCCCCAAGTGAACTCAAGACTTGGCAGCCCTGGAGATGCAATTGCAGCATTCCCTCCTGTATTCCCTGTCCCTTCCTTCAGAAGGCATCTCCAGGCAAGGAAAACTGAAGTCATTGGCCAGTACAAAACATTTCCTGCGACGAAGGAGGTGGTGCCGACGTGCTGCTTCCCATCACAAGCAGCTGCTCGACAAGGGCGCAGGGTGGCTGTCTTTGTTCCAGCACTGTTCAGGCTGCCTGTCATCCCGGGCCTGCCAGCTCCCCTGAGTGATGAGCACTTCCAAGCACCCCTCTGCCCTTTGTCTGTCCTTATGCAGTCACAGCCTCGCCAGCCTCTGGGGCGTTGTGGGAGATGCCTGCCAGGAACGAGCATGCTCTGTTGCTTGGGAGCCTCTTGCCACCTTCTTGGACTTACTCCCCACCTGATGTCTTACAGAGAAAAGTGTGACTTCAGGTTGAGAGTAGGCCCAGGCCCCATGAGGCACCAGTGGAAGCACAGCTCCAAGTTCAGACAGGTGCCCTTAGAGAGGAAAACCATGACAGGCAAATGCATTTCCTCTGGAGTTTGAGACCCTGACAAACAACAGGTGGCATCTGGTGTGCTGTTCTTGAGTTTTCATTTAGGATTAGTTGAGTTCCAGCTGGGTGTTGGAGAAAGGAGATGTTACCAAGTCTTGGATGTTAGGGCAAGACCTGCAATTTGAGTATTAGTAGGAGAGCTTGTCTTTCAATGCAGGTTCCTGGGGCTTCAGGGCTGGGAGGAGGAGCCTGCCCTTTTAACAGAACCCAGTCACATGCGCCCAAGCCACTCAGAGGCTGTTGCATTTCAGGGTTGTGTTGGTCCTTTGTTTACCTCCTAAACCACAGCTGTTTGTGTTTCACATATGTTGTGAATTTTCCTTGGTTCTTTTTAAAGGAATGATAATAAAGTTACTTGCTTT + CB%<67>AA;DEB6B/???B@1B?;@D=,=DABE;D;D9GB@E72?CB$8EECF=?/A<$+6;?'?>9FE2G<*=99CDBGFBDGIF%GEFDF.DC*:9CC@0CDEID4D@BEB=G5EG:GBEFG:A27HAHDH.EG?=?.@J.@?FI@0FIHHCI8E7B6B82@B<@,BFGGHHFC6H?9=GDHHFHHIFH7E?AC2BEABH9G+@DJGIIAE6GEEBA>EEHHBHGA3DGHFCA=??=B:CGEIJE4FG?IIDDI>>B,BFCA@ABBA=F7JIGIHHEBD>>FFB9AG>I@E9CFGAG@I:FC>>?F2EFEGG8E?@A7IDFD>GG;CEBA@C1DG@CIDIC6DBE>B?*FFHI8FE/?/EF=BIIFB==BE9GJF6F=IFEI<=IBDCDC=A;C:HF=D;,EBC;DDGFF0>C?5CC4>3BA>BDIH0B=EAC@BDE>C?IE:%B:.JGAGI=1?7I@GADD>7GFHH=CGCGII?GCGIEGFF@HGDDF@D?1%C@>@<5CCD5FD*DC@H>5=E>HEGFBBEE@?@C6A@>EH@FCGJ?JI?D@>FFAADBF:7:?4>,?@DGGDB3BGAHICH6EFIE?H3;GH83>>DHGD6D5FDG?DBGFGCJJBGBIGDFEE5FDHID@B0:>:GC598AAA<&>;=7A8@B+@??4??BH@3B9CEIAC@BA?HIEEH=H6>??IEI>F=94DFEIGC@C+=>FDF/4C@BFIF=A26AA8EB.BFF/FFF4D?E?E@I>17<=2;A3E>?@7FF2IJG?JED;HFBEA*@DJ3F*FJG@I(A>EJAGG2AAE@9?6=B>=8@BA3FEGB>>&8I:HDH=;EBCI$=9;1DHFFD5@?;CAF?*GG=D:E9GEIIDH+DGGHII9HH?FD=F:;2BG>=DD0E@FEG>A@A+A0@B7=:=IHHE7DC@I8CGGIHH0ICJH6GE,IHA6I=C>GEIB;EEEE,DDEEBDHFCFIGBCHGEHH>0AEG(HC?BCEAHGF4B?BFHI:IGCAG8F7IFID4IIFF:?F(HE?/EFH.:@B7-EJIHH?GIHGJJFDI>B:IGI8FFCIFHEH;AE>GDD?FHDFEFGIEBHAJI=A0>@?FJEFB*GB>ADFA@G=G?;=H??FI@HE>>;DCGJD@)><4:AEC6CABC9F?D1GE?E:6*;@EH7E9EDDFJCHAI?9BF1GEG9H>HFFDFGGE:DCDF7ECEEI?;JBJCHFH*H48+4:$AB?BHIGGG>DGFBF=9A,A@ECAHDJIFFFJH'BDHFFEE-BEFC>=5>@BBEI=GE5GEBAH?DIFC8JAHE=CE<=8EEA?1:/E7GE8IJGA=;BF3EI@:4H>C5DECIEB6CFF$DCFGII/FGCADA#?B:F;F@?DIHF&3@D:HE6GF;B<=B=.7=E?8E>6;9CCDF/B@BC=21)D8BABDEFED;9EFFJIAHE7JH5CEDBHB@E9GA@EA9EI5<@;8DCA0;FA?@;GGA9A?B9<>;*=> @rCer/2272/25_2044_CCS ATGGGGCACTTTCTCGGCGCTCCCTCCCTCTCGGCTCGCACAGCCGGACTCCGCGCTCTCCTCGCCGGCCGCCGCCGCCCAGCCTGCACCCGCCGTCCCCCCATTGCCTGGGCACCTGTTGGAGGCAGAGCCAGGGGTGCTGCATGAGGGGCCGCAGGGGCGACCGCATGACCATCAACATCCAGGAGCACATGGCCATCAACGTGTGCCCCGGCCCATCCGGCCCATCCGCCAGATCTCTGACTACTTCCCCGCCGGGGACCCGGACCTGAAGGGGGCGGCGGCGGCGGCGACGCCCCCACCCATCCTGGCCCCCTGGCTCTGGCCCCCCCTGCAGCCCTCCTTGGGGCCACCACGCCTGAGGATGGTGCGGAAGTGGACAGCTATGACTCGGATGATGCCACCGCCCTGGGCATGCTGGAGTTTGACCTTCTCTATGACCGGGCCTCCTGCACTCTGCATTGTAGCATCCTCAGGGCCAAGGGCCTCAAGCCCATGGATTTCAATGGCCTCGCCGACCCCTACGTCAAGCTGCACCTGCTGCCTGGAGCCTGTAAGGCTAATAAGCTAAAAACGAAGACTCAGAGGAACACACTGAATCCCGTGTGGAATGAGGACCTGACGTACAGTGGGATCACGGATGATGACATCACGCACAAGGTGCTCAGGATTGCTGTCTGTGATGAGGACAAGCTGAGTCACAATGAGTTTATTGGGGAGATCCGTGTGCCCCTCCGCCGCCTGAAGCCTTCGCAGAAGAAACATTTTAACATCTGCCTCGAGCGCCAGGTCCCGCTGGCATCCCCCTCTTTCCATGTCGGCGGCGCTGAGGGGCATCTCCTGTTACCTGAAGGAGTTGGAGCAGGCGGAACAGGGCCCGGGGCTGCTGGAGGAGCGCGGCCGCATCCTGCTGAGTCTCAGCTACAGCTCGCGGCGCCGGGGACTGCTGGTAGGCATCTTGCGCTGCGCCCATCTGGCTGCCATGGACGTCAACGGTTACTCGGACCCCTACGTCAAGACGTACCTGAGGCCTGATGTGGACAAGAAATCCAAGCATAAGACATGCGTGAAGAAGAAGACTCTCAACCCAGAATTTAACGAGGAGTTTTTCTACGAGATAGAGCTCTCCACTCTGGCCACCAAGACCCTGGAAGTCACCGTCTGGGACTATGACATTGGCAAATCCAATGACTTCATCGGTGGCGTGTCCCTGGGGTCAGGTGCCCGAGGCGAGGCTCGGAAGCACTGGAGTGACTGCCTGCAGCAGCCAGACGCAGCCCTGGAGCGCTGGCACGCCCTGACCAGCGAGCTGCCCCCCGCGGCTGGAGCTCTGTCCTCAGCCTGAGTGGACAGCAGTGTCCTGGTACAGGCCTATCGGGCCGGGTGCAGTACCCAACCTTCGCACGAGTGTGTTGCACGTTTACACGGGGTGGGCTGCCCCCACCCTGCACTACCTTATTTTTGTGAATCTCTGTGACCTGGGTCTGTCTGCTCGTGAGGGGCTGTGGAGTTCTATATTCATATATGCAAACCTCCTGCCTGACTCGCTAGTCCCTGCAAATATGCAAAGCCCCCCTCCTCTGCACACCCGGGCAGTGCTCAGAGCCCGGCCCCAGGCCCCCACGCTCCTCGCTCCTGCCTCTCCACGCTGCCCCGTCCCTCTCCCCCCACAGGGAGGAGGTCGGATTTAGGGGAGGTTCAGAGGAGGAGAATGCCTCAGAAAAAGAAAAAAGGACAAAAAACACACCCAGAGCCACTCCTTTAATACAGAAACTTCATTGCAAAAACCTAGCCCTGTACAGCTGCCCTTTTAAAGGGGTGGCCATCGCAGGGTCTCTGCCTCCCCAGCAGGGGGCAGATGCTCCCGGCCACTCGTTTAAATAACTGTCCCCTGGAGGGGACCAGAGTTTGAAGGCAGGGCCCTTGCCACCCTCCTGGGGAACACCCGTGCATGTTTACGCCTTTTCTGGTTGTGTCAGTGGCCGGAGCATGGCAGCTGGGCATCAATAAACACCTCTG + 8=.:2??473;<@>-;AB>?=4BB>0;?8=;18?=C:9?A:>:759==@;93FD@<475/123834:9:D=EB@55E?692877C-2+,194479+/2:43656<@;31:B8?8DD0A:>6886@4*7;-'11+28;@1<.:;?68:=6-;70;6/?C?9<=<=AD8?:2<:9:A3?:<(:00$@6BD?<49@C8B9:98<@1=8+4/7>>6?3<71>4:#2+//+757@C?9?E?E?5BAD8;'?897;,6)*.35332)8=1-5108621.--3<%-:/2$2'&03;:;):247,85:71?:78439B@965%=19<:6:+45-54*:4;563?=AD8868>4<4;.;@AEEA:D>@5<.@>BD7B:0@;<4=>@2=8>7?B6A86@=8C8/4,<=>@5=+3<6EA56B;6?A4>1,-7=;@8C:.=3;6:549=.=>BD4?:@9E5D@=AA45.9:<98;179=78:17=96.'3><7+;14>933,0>>;C>7<8@@B;8:7:>2@50<8<=>?>9C:::6>1D;?C5><<>29:3AB167;AA3?B=F7=88);<@C=BAC;ADCBD=>8>A@@BD=(@<8DA7<:C@??5>6C@?.8A>9A@D@FB>-99>@=B@,88)8<=:4;4=;40$A6;8EB>B94?AB?39797=?2;BB88AAD9;A>6;A8.:7A<=@>35?=680?=:9:<-6@?@ACEF@?:>66=9:=>98178/5575:9>BC4B>??@AD;=74997+19DF0562>B6:BDB@04824?=597547@0=D@.6/9<(5478>EF;';(@A;6?18>D:@=:24(9@CABBE>:>()08=,/:9C73=>C@AB8B?@D>0AD:B7?1@/9;E80:<92+?C7D:E@4:D<:>F5D7?8?):83A?;C59;9@CHCF:E>DBC7E=BHE8>G4FICIHH?4ABE$@H=>@CHC@ECFF<>B=C3D9A?@ADH*?B9FH?DA(CFF@H>=@:C77;?BDEB;;B=D@:)?65?61>DGE@87FE;EE@.<4@;C>?5FGHG?H@DEIGHEFFD>D:DB?AB==@C>96.=828%;9?:>+8FA2?6CDA>GFICCE>EE@+D6I;6>=11:9<+4>69:>?H9DBAI;;6C4;:6;:3CB==<@7:9C@B;@CBF/EEH:>;@7B>A;4D2AH76<=2>6=B.<<7=F:ED@:;E=4DEE@DED?HAAEEBAC=E:AC=CE>CA>FBECBDFF79C595B;2B;6:;769A:;+60:A@@AE?>6D6@;@>H@/?9=DC938?CFC@BGDG>=6;HFD-FA99@>>B?:?BHHBF?4>7@=86FGCH=CBA-3*A:79;8789;E>EFC>1=?F;A3AA8CCA)75=<88223-367%3074AEDG@E6CA@CD9>B:444/BBCDBEH6/3?8567@BA=B+@A@:3C5A=4B:5;;=-<=>.85,@CB9/>FEC.788D.HHFHG@IKDG:/9;5<;GJ;D@H=C3DIGKG0EE?8AJKJE7HCJC>E<9GIGF;=:DFJ:HGFEKEHGF4EE0FKHIC;IBDK:DGCF?HFI:=@A@AA@GIEAIH;IHCC?=@:CHGJACHEFBA5DF>>EAHID;KCFG>D9HA.DB9DFGGH;@6FH8F@>7C;755: @rCer/2275/25_1696_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + KJGKKJKJK?KKKKKIKKKJKKBKKKJ)FE=@IKKKKKJKJKJKKKKKIKKHKKEJIKHKHJKJJKJKIKDKKKKDKKKJKKJI=@KGKIJEKJCKJHKIEHKKJJIJKJKGFKKKKIJKKKKEE3KKKHKIIFHJKK2KGKIJKKKKKKKKKKKKJKKKKIKFKKKKK3IKKJKKKEHIKK>JKKIJKIJCKKKKKKFKCKKGDKKEKKKKKCKKKKJKKKKKJKKJFKKHJKKHKKHKKKKKJKKKKKKKKKKKKKKKKKKIJKKE?KJKKKEKKKKKJKKJKKKKKKFCKKJKDKJI8KKKKJDKJKKGK>KKKKKKHKKFJKKGKKIIKKKKKKKKKGJKKJKKK;KKKKKIKKKHKKIKKKKKKKKKKKKJKKKKKKKKKJKKKKKKKKKKKKJKKKKKJKGKKFKKKKGCKJIKIKKKK8KKKKKKKKFKFKHJKJKKKHKKKJIIKIKIKJKJJGKGGFDKKKK7IFJG?BKKKKKKFKKKKEKKKKIKKK?KKKKKKKKKKKKKKGKKKKJJJGKKIKKKKKKKKKIKKHKJJJKJKKKKIKJKKHHK8KKKKKKKGE(KKKG4KIKJKJKKKKKGKKKKKKJHJIKKKKKKKKIKKKKKJKKKJKKKKKKKKKHKG?KKKKKGKBIAKKKKKJKJJK5KKKKKKHKKKKIKKKAKKKKKJKKKKKKKHKKKKKKKKKKKJKKKIKKKJFKKJGKKKKKKIKKKKJGKKKKKKKKKJKKKKHJKKAEKHIKKKKJJF8KDIBAI4JKKKKKKKKKKKKKKJ2KKKKJKKKKKJKKKKKHKD?JKKKIKJKKKKKHKKKKKKKKKKK:KJKKKKJKKKKKKKKKKKKJKIKKIKKKKKKKKIKKGKKKKKKHKKKEKKKIKHKGKKKKKKKKKKKKKKKKHKKJKKKB?KKJKKIKKKKKKKKJIFCJKKKIKIJKKKKKKKKKKK7KKKKKKKIKKJKKKKKKKIKKKKK8IJGKIKJEJKJK7KKKKKKKK4KJDKKIKKKKKKKKKKKKGKJKIKK@KKKKKKKKKKIKKKKKEKKKKIKKKK7KKKKKKIKKDJ+HJKKKKKIKHKKKJKFHKKKJKKKJKKKKKKKKKKKKKJKKJKKKKKKKKKHKKKKKKKKKKKGKIIKAKKKKKKKKKKKHKKKKKHKKGKKKKIKIKKKKKJKKJKKKJKBKKKJKKKKKKKKKCKIIEIKKKKJKKKKKKJIGKKKKKKKJJIJIIKKKKKKJKKKKCKKK3IKKKKKKKKKKKKKKFKKKKKKKCKKKKJEKIJJKKKKKKKKKKJKKKKKHKKKKKKKJKJKKKKBK5KKK9KKKKKKKKKK2KKF@KKKKJKK @rCer/2276/1724_57_CCS ATGGGACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACGCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACAGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGCCCTCTGGGAAGAGTGTAAGCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAACGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCAACTTCGCCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGC + 36?;/?4CBB=CBFFEF3?E>CE7>??ADFDD@6=A<+CA0>=CBB=BE8;-=4GABD1@BB=><11)98=>959::A<==>6.A29>>(68;;:D=>BEG=ED>*BC6@@?B9=AA/AGDFG7CG>:2917FB799F9@AE79@B=4B6'E<6=B-C;D<@;@EB@A9)B6>@C=90:>5=BG@AE6<3?E.GDC@:<(@FEEEDBC2?>>(;>AC(9<<@ECC?F?5=<8BBEB=AAB.>A?;;:=;@2?AC=EBG5A@>8:?8897?65@7CA@:C@ECGECG3ED<@2==F5:>@*<8C<77D7=G,?AB==AB:=CA5CBC=9<354998$6E90.8?7/?0>>@BC>61:>#6:@(B;:@);??;A9=DE<4DFFDF7;AB63;@>C2@<@=:A5CBE:9G7BADEE@=6%@:>5E8?@A>@9>=F<>4>@EE=E2<6D8@=:76@ABA6(BA-B>?3@:?9D;?C>D5@*@CD>AE?>DC;A:DD??E4;D@>?,.6A8F:FC=3ADAEECE=@AA=@+AAE??96<2?E9??A/9=D8B56,>B:FE291B1;A>FFD<0BE7=8ADE*>B@><<=7@BGB?BC*2E4E2=A1C6BBBA:38>;>9C;>D1=2BCBD,E@7CDFFGDB=19EFEC?C@75A:>FGE1CBF=E?C::<>>>53<<=37E5=AA:FC;=494<;A8??5?D;EE/G7G:?:C/@?3CED:CEF23:E?E<;3?6=>CB=8F?D==0;65-6A4:;7:;86;3=<587?8;0A1;>>B.;=B:7;<>=39@A>8@9??:<91A?<8>98<;BA<<;-:A@9?@7?@=>:@;4=?;?B75@5B0@=@<<=>A*AB@:=>::<@=<56@B?=A@<.?BB?=67;275@AA:=B9@@9>@<::?=<:;/?0;=@>?@8:A6>BAB0A70<=95/:;:(4;569;>0=8B99@6=8=6@>A>0=@B:@;8032<3?AB=;@AAB>68986?&==;@A7;>>3?4BBA9ACC=='47A*.6=5::999>?:(,>6>C2<@4=<=;?<<@78C@BB93>=?C?9?>:9A>@A5??AB>.@5@=@09>;19AB>=>?B@>;B5BB>BB:><0>>>866B@466C<;9:.;BA:6>?89<:@7BC<97@C;C?>=><2@=4=AA:6?>A:BBA@;995B>=0>?;A=@;<;.84.882=6698;%28AB5>;27.>88<@8B<7<;>9=;AA?3=89@5>8=?B@B0:>=:;<-2265?=<9AB=;3?4;0;:;8>?:?:@B@@@A4;35=B@=6A6-:=A;7=;27=:?8><6=;1:=;68;)578+;?=82(616%421<8:27<(?@?7:=<=9.@?97:;:3=9:?A=8?;<58?;9:AC7?<;>9=<<@<8%:/38(<7:@,<;>>79+@9=68?CCAABC>1/8B<0,5>%;;7/)KKK?GK9KJEKIJK,KDC@DIJGD;E%IKKBKJGJJF?G):1IKCIJKJJG?GIJHICKKKHKKKKK:KKJK?KKJKKKEIKKKKKKIIKFKK4KDKKB0BKGHKKJKKK?HJCKKKIKJBKIKKK1K5KKEK6JFK%JKFKKGKHK@IKKK->KJHGHKK'CE@KKKK4JIJKKJJ7KHGIJJKK?AKK*FJKJKFKKKKKKK@KKK<0IIJKKJ%K@KK/KGK-KJKCKJKKJIIJG8K@KK?DFKG0'J@HH1K0KKKACK.7JK0GAKJKK1DK-K5K:KKKKKIIKK+KK,JKKK/KFF-HK+BAKKKIKK0JKKKKIGJKKKK-KAKHHKIIKIJK9IKKDJK(KKKKKBJCJKKIKAKK;>K7IIHKK8KFJKKIKJKFKKKKKCKKIJJKHKKHKK4KIKK;KKKEKKKKKKKKKKKJKJGK?HBAJK8KJDKKKKKKJKK5KJKK)JKKHJJJKAGHFK5GKHH5KKJKKKAJK=JKKKK@KIK:KKF4K7KBKJFK@KKKK@JKGKKK@BK;KGGKKKKGKKKK9KKJKDGEKKKKKK6GKKK6B?CK=CKDKEJE7ACHKBHI?GKK(JKKJAHKJJIKKCJK7KKICJKJKKIIKK;KKKKK@KJKKFKKJIIH$KJGJKIKIDK/EK8K:IKGEKKGG-;KK.JKKKKDKDKKJIJAD6FEFKKKE.IKJIKKKK@KK@'F%CFKKJKKGKJKKKKJF)>KHBKGKKKK=JKJJKKKIKKKHKGJJECKK(KKJFDHIKKHJKKAEI'JHFKK;KK9IDKKKKJKFK?KHKKKBBJKKGHIKKIJK;KJKKK:DKEK>KHK?JKHJKKJ7KKKKKKKKKJ,;KKKKGGJ:IEKJKKJKKKJHKK-KKJJ@JFJJ1IKK:KJKBBJKIKKKKKKKKKKKKJKDK3KKKI;>;7@D>.K@IHFKK@K9JK7JKHIKK>K.;JKF@KK5KBE@>&EE,K2KHKKKKK2KKKKAFK(JEKJIKK,H9KKJKKKK;K63&KKKKJKJG$JKJKBKK:<69?>7+9<468==<8,98>99376:782622-85269234*(83=>.=.3,52=6273<=,-'6:616&4>8=<<;;:(36&41%0:.=817)3#)67,<==89=:.6657'70;858:1&20:6%65*0<;;(8:2227'9=8=9869=:/3697+=788*7:)4175520%,-::)32.7165+20.7999*4'752839'18128:<*8&2*69&4&=688'<<==>>392331,3.915)21859==<8:4420.821)2)318>.>:><=3:;8974.====='38>?9;1;1==04:019564118<-<8>::94*62,%*4/*.529>9::78:><864$69564&:;7-437==2=*=79<9<=;?=9?9=17<6;68>>>3763&.)<-;00142419.8105,4.2152-55;1=:30483=95/6588=<6;/*0;&0585)>49?9;:(777>6/?86/5+.%16*446&31779%77430;:6+.197<<293:>8=:;4=2;+7<6/67,989:,7;.97<1:78:=052-?<:<:=9*9<809:73;;=*6(818189<79:5;98'9;;9=<<5=;51;773;>,)<;=5%6788624673;:9%'2*;=<-<36;<;=0=96:;572-;$.3=7==97=,;;93?58'2490=>?/>=28;<9:93923*:55-/16:5548832'7636(*69168;2179:<184692$-1;8>8:2/8.6:86405$<=3<<::=2=<52098893?9:667$883964=6:,;;>?9?9<;%8?;:6240>=*2(<1=9:5:/)10--(%+1=1=:2?8:8-;>-092178999;6$2/7323=9-%-<<.9-4:52:$0838+<<21=7)2<:$'*-'%'13/4:,9::18988'6638--$6&06-%0035.01(6:59597365%9;9:/35/9:955(7784455%853758.23318-63/1).45:2342,802&+)&2+7,8'56/27)*4:255,59775+36.*5%'+0-'63$38')'82-53.14$25.9+411,9036&-7$2;789)9848449/78/557:76499(573719::143'45./55541.711%,*5752&45,+0,-.%0,2*(16456&77(/)37)9:1,:-;85:-08-/6/&313;54(43441(4.94576&63;947&3553.8.056&477-74-64014%5/03038273/121%36.,*2-26264112%060.5/320/,$0665.63/254(.&5-22+,(31130--2351643%42033/2006001300,,2*+5$.355*214541.15'/4511203$3411*(--2,.2%3*502-0%01,+1/30*+'/(0224044)1/*.-0(152215353224.565666/044'51664+-)/222423.00551565352,5,0156511/.41)+31242/30-55625616600+61+/051.1226/0)124)$*+1%656,06/54)-41412663.0-&0040/3*523.6215.#*2*2&&%+.'122-144*02)4+)*-+3&'2%)-535341*'2.,#/422)-54126665-)1'1)22)41111+13*3-341506-).4)31,55+5626.-),05)3../6/)).(.156611150)555551*431124%,33&1/31055204-530(.20*1+13,3554&)4,-0*352*401+333,05645,56514/2.(*-.4621352332$...05240%(465553410'525,-051'532,$'44)12'*/2$200 @rCer/2281/25_1654_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGATC + ;;.>::<9/>=<=:(9:<,:56:=?;>6>?=?6>9:>=?<53$;590737378=;?<>:;9<=:>>>7:7>=>48>==9?>22:=::8=<>/<<::>>644?0<>79=7?<=:0<;209<9(;>99<4>9696=?7==28/$53:=0=><-.66;>?>>29<=%;99;:3:;7%8:8:6?:7<<<%64:=??9>=9<.975,8:5<%7;6*43100650887432559+;7;=;;6;<;85/<2>=8698:*69,//2924:=658889=:=:63:<8,>:=>5<>8=>>:::55=;=:6>;7>=*:888:970879;<697:3=96-7;:449::::0451065<;;:<=28941<;1=5=7;99=96:>9?>?1<38:20878>:<;===:=86:4A7:BBAA8:,706:;???B?@ABBB73>?C=<:866A>62@?::589:>B3?5=:>=:B@>B>=?:;;@@C?CC@1?>:@=B@*AA@<<5;:09;3;89/9922(98'5:@@B@?5=>>=;AB7ACA@B1@<@7=AB9@=@=:CACA5B@2:=A=9A?A@3@>9<<@<;5:?:;@@=?:>?=8>A7=@9@;?98AA<2@17>@08?:AAC:6%@;;581:.9>A9B@>@@=>>3=>A>=B@A@;>?==@B7?@3>4276>7?335$(526<<>CC@=CB/=<;:3<5><1@:9>9==B>>;B@?ACB3@??1?2;;9;<29=9:B<4;/.:?C@C6@;C57@=8A:AC;=B:A>=44:6/4A:>=ACB;A;ACA9;=<<::;:;8CB8AAAB6;:;9:3:@9=9,265=6>9;<83137857;959<5*82:;428B9C2>.39=&555:5?=<>AAA;?87:/9<6=9;=<269;:<5;8647497:0<-4003492587989<30688<<9;449:>9:8936651275652,**$/(&0+144/88<=@;=92CBBC=:@:@3>AC?B=6@@><3A==4>/?<=>=CA5>?@>AABBB@B4:<9A+@?=9:=>A@6?AC7>?.@>>7@8/AB?:@>@?>=/7?69?@=?><575344<5B>?@BAB=;256<9<:<;75557569:889=@>;A>@<5>7=?C?4??>=2=>A;?12*>>?=A?=AAAA?6>5;:<=A9AC6;8@<<==;:4;8<:=B>?A8>?<9==A;>B;@>?;8A@<5>78??;B6=;<>,7=2@@6=@@;B8B@:=<<=??9?=AA=B=:41)=>7>::@9=<=6@?>A5=;78.=5;B<@?9A395>:A>>;?BA7?4<>9;?600?=@;B:<<7>58=<3<>=?>>@>>C=7=6>73<2>;1<>>;B@7=9@;>?>?4@535(-796;6-<8:=:><<=:929=:>9?9=<;9<8;>9:3<=>6=;<2;2<<8>==8<<=9<77;6:;:;5=<9:<,9:;;;>:?:>7>>?1 @rCer/2285/1584_65_CCS ATGGGGAGAGCTCCGTGCGGCGAAATGGTGAGATGCTGCCCACCGCGCCCTAACCCCACGGTTCCCCGCCACAACCTCCGGAAGGTCAGAGTTCACATCCAGCGGCCTCGCAGTAGAGGTGGCGGCAAGGGACTGGTGGTCAGCCCCCGAGGCTGGAGGGCCCGGCCTGGGGGCCTGAGCACCCTGAGTCGGAGAGCCCGCTTCAGGTTGCACTTCCCCCAGCTGGCCCTGAGGCGGAGGCTGGGGCAGCTGAGCTGCATGTCCAGACCCGCCCTGAAACTGCGCTCCTGGCCCTTGACCGTCCTCTACTACCTCCTGCCCTTCGGCGCCCTCAGACCGCTCAGCCGGGTGGGATGGAGGCCCGTAAGCAGGGTGGCTTTGTACAAGTCAGTGCCGACACGCTTGCTGTCACGGGCCTGGGGTCGCCTCAACCAGGTGGAGCTGCCACACTGGCTGCGCAGGCCTGTCTATAGCCTGTACATCTGGACCTTCGGGTGAACATGAAGGAGGCCGCCGTGGAGGACCTGCATCACTACCGCAACCTCAGCGAGTTCTTCCGGCGCAAGCTGAAGCCGCAGGCCCGGCCCGTCTGCGGCCTGCACAGTGTGATCAGCCCATCGGATGGAAAGATCCTCAACTTTGGGCAGGTGAAGAACTGCGAGGTGGAGCAGGTAAAGGGGGTCACCTACTCCCTGGAGTCGTTCCTGGGCCCACGCACCTACACAGAGGACCTGCCCTTCCCGCCAGCCGCCTCGTGTGACTCCTTCAAGAACCAGCTGGTCACCCGGGAAGGGAATGAGCTCTATCACTGTGTCATCTACCTGGCCCCGGGGACTACCACTGCTTCCACTCCCCACGGACTGGACTGTGTCCACCGGCGCCACTTCCCAGGCTCCCTGATGTCAGTGAACCCTGGCATGGCTCGCTGGATCAAAGAGCTCTTCTGCCACAATGAGCGGGTAGTCCTGACGGGGGACTGGAAACATGGCTTCTTCTCACTGACGGCTGTGGGGCCACCAACGTGGGCTCCATTCGCATCTACTTTGACCGGGACCTGCACACAAACAGCCCGAGGCACAGCAAGGGCTCCTACAACGACTTCAGCTTCGTGACGCACACCAATAGAGAGGGCGTCCCCATGCGCAAGGGCGAGCACCTGGGCGAGTTCAACCTGGGCTCCACCATTGTTCTCATCTTTGAGGCCCCCAAGGACTTCAATTTCCAGCTGAAAACAGGACAGAAATCCGCTTTGGGGAGGCCTGGGCTCGCTCTAGAGCCTCTTTCCTGATTATGGCTGCTAAGGGATCTTTTCCAAACAGAGTGAGGGTCTTTAGAGAGGGAGGCCCATGAGGCCATCCAGGTGAGGGCCTGCCTCAGAGTGGGTGAGAGTCTGACCAGGTAGGACTTGAATGACTCGGCTCCCACCTGTTCCGGAGGTGCAGACAAGAGGTGGTGAGAGCCCCTGTCATGCCTCAACCTATCCTGTTCCTTCTCCCTACAAATAAAAAGTGCAGGCTGG + GKKJH(?GJKKIHFKFKKIGFGHK/IJ:GGIGKKHCBKK@1GKABHCDKBKKIKKK?KKKHKJKKK@HK8A3JB2KK$JHKIGDK4JJKKKKKKCKKK7KKIJHKK&?J9C0KKKKKKC)KKH)KK3KJKIKDJJKGKKIKGJAABIK=FHJI*KEKIJFJKK9HFKHIH6KIFFDJEBHG)FKK>GKKIKK3KJ@KJKGJKKKKCKK9KKKHIKFFK9KKKEHKKKHJKKIEHJKGKKKKKKKKKKDK4JKKK=HIJKKKBKBKHKKIIK>HJKKKKEIH@HIKHGFKJJKJKJKKKKKKJJKKKEFHKKHFKIKKKKKKAKKJE6&>GJ>KHGJKIKKKKJKKKKGKKKKKKHKKEKJB1IKEKIFHAKJKHD8KKKKKJGKKKKK8KHK@KKJKJJKKKKKJKGJHIJ>GH@KJKK9KKKIKKKAK8KKKKKGKKKKKGJKEIHK>=IJIFFJKIKK@JEDJ1CFKFDJKKKBJKJBGKEHKKKKGG@IDIKJJKKCHKKAJKKK/KKKKHKJ;IKK,AKIIIJHKKKK*JKKEKK8KKKKKKKK1?2;)IGK@CJBKKKC)K@DK%KKGJKKGHK7JKK=KKIHBKK>KIKKGKK=KCKIGKKHKKKKK:KKBKHKK9KDKKIKKKJFKKKKKGKKK9KKBIIKJJK5&BBK**KK(JKKJKKEKKKKKJKHKF8KKK$EJK-JKKKJJJJ??DAK.EJ2H2HGKCKKKKKKDKKEKKKK:IKKKKKIIKKKKAFK*KKJDEKKCIKKKKKKKKKKKKCKKKKKHKKKKKKGKKHIKKIKKHK:FGKGJAKKKKKKKK6HDJK=KK7KKIKIKK?KKKKKKKKKKIKKKJJHEJKK2C6KKGKHKKJKK/KKKKKKHKKKKHEJKKKKGKKKKKF&IKKHGKJKKKKKBK?KKKAKKK3FKJFIJKGKK6KKK@KIKKKBKCIJKIKKKKKKIKKIKKJK@KKKKKKKKKKKKKKK0JDJKKEKJKK>KKHKKJKJKIKAKKIKKHKK9KDKKK;KKIIFKCJKKFKGKKHIKKKK:IKK@KFKK.KJKKKKKJKKKKKEKIKKKKKKKK'KKEI3KKKGJ%KKJKKKKKKKK1KKIK'IKKJKKKKKKKKKJKKJ@JKKKCKEKKCKEKKKJAKKJKKEKK0KJJKKK9KAKK/HBHJDGFKKK&GKKK&BKKKKKK:JKBKK=KKKKKEK7GKKAKKCKKKKKJK>KKKDKKKFKJKKKGKKKJJKKKHJHK=7766882:78;>:?/=>;9986=84;262=;15:?96;:>=:55836:>869;96898:<79;?7<940'2175/4<-84*):603/:/723552.444763;83268<9/346/97<:-7;;==3;'3:0-787<:5'755&/:556%8:;:6257:+>=?7,;>>>:=?07617*>;8184==-.1-.()2-42:78<4;=>6?=?89;?<9>:4788<)7?99=69.-$49<:=?8;7944?=&6897/6:38=:'4:6&679987:83:998<886578154(1(-0*/.4876/9;>4<6;>>=:3=:'37:23:?>:5=.6=<=:96;>4:<4:49.>58>.3314606=9-9:8<5>8921$;911>9052=:9?><7?>>,79;2/:=:<1>.668:685>:4==?2==>1<0=9>1>2=98<:>83;<:==780503466<8)7;=?>?4:=;68?8C?1>95<>3>@A8?>>;6;29:84;A;68;:;+=<5(9;;93&89::2-===;:>6=79259<9847@B-99.:8:71;:8885=>>>@C?B>A=>C;:56:/?:)>5081;8801.,144;;<7549:==>;;.?7:7:=:89(2*279(@@>@/?BA;=?=4=BB<6@@>>?>@A:>?@1>;,7;?6@?-56B?5?=7ACC=A>5;B38?9@ABA1?<><=<@5>=A@=4778A2=:295<9:>?7:;8=@2057?:897'<@87963.5?:;?2=998986,-4+,.+/6+474'366;69$0111:42+3782(05/6*56.6%9/32-6582:?@>B34886:9:<*=<4620;-49880;8:0818=>>:C?755963)37790415<273.3*;&%(359>7:26469760885;=4@=7>=873?;8@;>@==9:B?=?==7@AA?A+>:B@7?49=4:21140&--5306377567(---&>637:9:;5;A=7@?8;:.6:?;>AB>:;?*?51=:7=<(@@;7?8:5A6@786:?219>56:=@@>63::7<0;<;;;@4=59<:=:<929/:-:9:>=<:?9A>:,5;67<.:99=72,5:><81;CA>9;::5=>69@-:23<:;6:9-.5AA<%11865)5)20=55;>3?88;BC;,<5-=@=9;?:<):=<;883>?7>7<8;.@7<87%288;:<-7-+-2/55603*-13.66/31,87>=8-:>=?5A;@5;'48?*6;33904>>@6;9958-/990526<<42967>2.=59<>3%<>;<77;;9865=689=>?B=9B@%569576.9;>962/:8;A195A8->?<1$6:=>4$-7:=:334>;;<=A?:593;>=@CC?A?BC546A:9A1507;<.:9<7--=::698>62254:79A8==(8<=:;73?4<=?29*539>B9>.;>=<7=>3>8?A@7:>=673?=90@=<;/=;;=:<>:A..:;=;/:0*++74)90?<9?9=B=>7=>A=6070?72974=A>::A48/:.7=9;5>53<45?/;5>8?875<7:6:0<=1--::.-;;??BBA9A;=3@;7(+4<;<>267=0)():1:9::6@75;9:/0779:45=;3;A8<6;8614:8,9:9@85020-*6578=>:=6=;539?=?.:9;6406377+:>/7211;;5;;+2)*&(/-:;;@=?9=A>91:21,/%.'6$8720-75C;A2877;4(10484=7?<6<<<5A@<3;533./55<;1=>:=+<3;58;337;,;9>?@;>?>=84;=8=6/6,-37682/6238972:96$33+/2333..426627>;/6=;+5580)==969=7B=A:B116>;4;9===/8798'2?;0;970A4;=5;?8)2674;7=:6;?=>;1>7,;5%.=;@78>8%<;7843'@>66664=: @rCer/2288/1719_57_CCS ATGGGACCCTCTGTGAACTCCCACTGCTGTTCACTCAGTTAATCTAAGGCACGCCAAGGGGTCTGCAGGAGGATGATGTCACAAGGGACTGAGGACGTGGGAGACCACCCTCCTGCAGGTAGGATACACCAGAGGGCCCAGGCTTGACTCTGTCCTGTGTTAAGGAGGCAGTGGTAGTTTTGCTGAGCTTGTCAGGTGTTTGTAATGGGCAGCTGGAGATTGGGGTCCTAGGCTCAGGTCTTTGAGAGCCTCTGTGTCCAGGAGAGCCCACTAGGCATCCAGTCATTTACTGCTTTAATGGGCTATTGCATGAGGCTGAGAGGGGCAGTTTCTTGCATCCGAAGCCCTTGGGCACCTTACGTCCATCCTAAGTGGGCCAGAGACTCCAGGCCTGCACAGAGCTGGCCAGAGCTTCTATAATAAAGGGGTCTCTGAGGGCACCAACAGGAGTGCCCATGGATTTCAAGGTTTGATTTTAGAGGCTGTTTTTGGAGGGTGCCCCATTTAAAGCAAGCTGATTTGTAAGCAGCAGCAAGAAAAGTAAGTAGAGTGTGGAAATGAGGACTACATTGCCATCAGAACCTCAGACGTATTGAAAGATGTTGGGCTTGTATGTCCTTAATGAGAGTGACGACGAGTCTCCTCATTTGTGCCCCTGGAGAACGTGGATGTGGTGGAGACCCTGTCTGCAGACGGTGTGCCGTGGCAGAGCTGTGGAGCTCCCTGTGGGCCTGCACAGGTGTGTGTGCCCCTTCAGGGCAGGAGGCAAACTGCAGCCGAAAAGCTGTGCAAGCAGACACTTAACAGGACATGTTAGCCAAATCTGTAAGAGCCAAATATTGGCCAGTTATTTATTGTGTAGAATTAGTAATTTTAATAATAATGGAAATTGGATAATGGATGGGACCACAGCAATAAGGTTGTAGTAAATCCACCATAAGGCACCTGTTTTTTTTTGTTTTTTGTTTTTTTTATAGGTTTAAGGATAGGAAAAATTGGGCTGTTCAATGGAGAAACAATGGATATAATCACCCCTTTATTAATTAGTAAGTTTTAATCCTTGAAGGCCTCATATTAACTGTTTTAACTGGAAGTTCATGGGGCATCATTTTATCAAGCTAGTTTGTAAGTACCAAAGACTGACTTTAATTTTAATTTATTATTTGTTATATTAGAGTGTCTGCGTCCAATATGGGATATTAGGGCATTGGGTGCTATGACCATGGAGAATTTAGACAAGCTATAGTTAAAGTAAAGCATAACTTCCTCCCGCCATTTTATATTTAGTTGCATTTTTAAAAAGATTACAGGGGTACAATGTTTAGATTTAGTGAGATCTCCAGGTATAACTGTTATTTGAGCCCCAGTATTAAGATTATGAAGCGGCCGGCGCAGTGGCTCAAGCCTGTAATCCTAGCACTTTGGGAGGCCGAGACGGGTGGATCACGAGGTCGGGAGATCGAGACCATCCTGGCTAACACGGTGAAGCCCTGTCTCTACTAAAAAATACAAAAAACTGGCCGGACATGGTGGTGGCGCCTGTGGTCCCAGCTGCTCGGGAGGCTGAGGCCGGAGAGTGGTGTGAGCCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCTGGCCACCGCACTCCAGCGTGGGCGACTGGGCGAGACTCCGTC + @EDC87A@5<@<=@BFA>=@C+?@>DC=;>9?=:::;DE984;C>EECBC>:08A:BADBA72>@76%AEFGEDA?CB,@;33A5:?7F>09C?A9B:B>A:>(?3EA?F;@@B>D:@>>;?C4ADCB?8;C8DB@374>>E=;=A?,A?@(CCBAD??A>?>1DAE5>B2B9CDF;9BA9EB@>DEA7?F@B?@C>>A@?:@.A?/C?3BD??A=@A:>=>%;-CA06BC;G9?@AEG?@>@1>ADC@B:CD6E@;ECFA><@CDF9?;<@?BD=>A9?AA@D?DC?<@B@E;?;?B8=@7?:D>2B(AB?DA89C<872;@A;=<.<;AB?1D:A@A4DA=:@;8?BE:71<<:<@0<9@5=?@B?;B;;51@?A<4BDBBD@99D3?CD:CF>=;-1?07=9;::==>7';1;>AC:3=A;??A>;=@<=;5?@<=>9?A@A>>A@;;910;7:7=@=>8;9>?A9:8176686037==66<6=;=@8745562=8=/4:9=7?>>9?838)3@>6?<98:$;7A@B>;B>4=766=:6;;AB3:5@<5:)B@@37A>>:=6696@?@<94;@B89274)78BC?==@8=;@;8?;A=@;59?=4A<=;.78+71>/979=3/600;+/)=;6;8<<=/?9:>7=97BBA:C;:><<3?75;<>>@;:9=:=>;/<6>>6-7&?C:>A8BA@:C>B?>>99=?CA>>48#'CDACA11>BECD??(5AD4BFCC:FD:=4=77@?+@?=CC7=8<7E>;?@A@>8;?A?+/8C9(7-5?:A0CF@>+C@CDFE@E@D;BA@=CB5@:CD?8D25B.D9D?BC8?:4CF@AEAFDGBB/A@E5>.A<4B<63BD?=?9FE;@;B@:@B:?<7>>?;B2F@<=?AC(8=6=:=;>.<8B:79)@DBDD0E>CBDBGDDGAE?AEB:ACB<>?A;=FD:D;DA7<=8AD69@>EA?DG7CE7AF9A=C49AADD@@6@D@A-DC=>>;<)@BEDE@FF?A@CDD@@AD1B?:A:?AD;?@978=A>@@@D6=A<=:>=E?;AAD3>>C:?/@$/77CFCGBB?C@>AB>@DDE8@B5BCDA:ACE9@G-AC7B5A=;>@C>4>A9>CB@@;27-;=CD8;05:AC=DBC<@EGCDA@FCD;>E?B>8DE=@A>(>DA:AEC9:9AADC<48??DDEC>7?=C:A@C=<@B8@8@D8:>5?@91@=255?@>3E@?C<<;>@8>DDBE=;=B>=>>?EC=DBBDCCDC@F?FC=@5A??A39=6FFBFF??C?FFA @rCer/2290/1698_61_CCS ATGGGGGGTGCTGCGAGGTCGGCGCGCAGCTCCGCAGCGGGTCGCTCGGGCGCTGTCCAGGCGGAGCCGGCCCCGCCCGGGCTGCAGCCATGATCAAGCGTTTCCTGGAGGACACCACGGATGATGGAGAACTGAGCAAGTTCGTGAAGGATTTCTCAGGAAATGAGAGCTGCCACCCACCAGAGGCTAAGACTTGGGCATCCAGGCCCCAAGTCCTGGAGCCAAGGCCCCAGGCCCAGACCTCTATGATGATGACCTGGAGTTCAGACCCCCTTCGTGGCCCCAGTCCGCTGACAACCAGCAGTACTTCTGTGCCCCAGCCCCTCTCAGCCCATCTGCCAGGCCCCGCAGCCCATGGGGCAAGCTTGATCCCTATGATTCCTCTGAGGATGACAAGGAGTATGTGGGCTTTGCAACCCTCCCCAACCAAGTCCACCGAAAGTCCGTGAAGAAAGGCTTTGACTTTACCCTCATGGTGGCAGGAGAGTCTGGCCTGGGCAAATCCACACTTGTCAATAGCCTCTTCCTCACTGATCTGTACCGGGACCGGAAACTCCTTGGTGCTGAAGAGCGGATCATGCAAACCGTGGAGATCACTAAGCATGCAGTGGACATAGAAGAGAAGGGTGTGAGGCTGCGGCTCACCATTGTGGACACACCAGGTTTTGGGGATGCAGTCAACAACACAGAGTGCTGGAAGCCTGTGGCAGAATACATTGATCAGCAGTTTGAGCAGTATTTCCGAGATGAGAGTGGCCTGAACCGAAAGAACATCCAAGACAACAGGGTGCACTGCTGCCTGTACTTCATCTCACCCTTCGGCCACGGGCTCCGGCCATTGGATGTTGAATTCATGAAGGCCCTGCATCAGCGGGTCAACATCGTGCCTATCCTGGCTAAGGCAGACACACTGACACCTCCAGAAGTGGACCGAAAGAAACGCAAAATCCGGGAGGAGATTGAGCATTTTGGAATCAAGATCTATCAGTTCCCAGACTGTGACTCTGACGAGGATGAGGACTTCAAATTGCAGGACCAAGCCCTAAAGGAAAGCATCCCATTTGCAGTAATTGGCAGCAACACTGTAGTAGAGGCCAGAGGGCGGCGAGTTCGGGGTCGACTCTACCCCTGGGGCATCGTGGAAGTGGAAAACCCAGGGCACTGCGACTTTGTGAAGCTGAGGACAATGCTGGTACGTACCCACATGCAGGACCTGAAGGATGTGACGCGGGAGACACATTATGAGAACTACCGGCACAGTGCATCCAGAGCATGACCCGCCTGGTGGTAAAGGAACGCAATCGCAACAAAACTGACTCGAGAGAGTGGTACCCGACTTCCCCATCCCTGCTGTCCCACCAGGGACAGATCCAGAAACTGAGAAGCTTATCCGAGAGAAAGATGAGGAGCTGCGGCGGATGCAGGAGATGCTACACAAAATACAAAAACAGATGAAGGAGACCTATTAACTGGCTTTCAGCCCTGGATATTTAAATCTCCTCCTGTTCTTCCTGTCCATGCCAGCCCCTCCCAGCACCAGCTCTGCTCAGGCCCCTTCAGCTACTGCCACTTCGCCTTACATCCCTGCTGACTGCCCAGAGACTCAGAGGAAATAAAGTTTAATAAATCTGTAGGTG + B>BBCAB2@??4EE>=DA??97659?CCF?7@>BD@CFCF>?A2?>B;BA@E=B2AC<;E8=C?76:AE:AAA2DD@8DB>><9<>:B9D>ACGAB?@B@?D?-6DBDBC9F@><::<62<0=?936>+A=BBC@7;9:;A6>/=@BB:+0>>;7%9@;C94;=:>A==A>>;>CA;:9<@<3>@8>@>>>.@2<=5><@><7B==<>A>B<<>;7>=?C=?=?@=<788>;*<6@8>>AB<36=5=A;=CACCB@?C?=C;CAB:>97@<:35>AA@;:B;>6C=?:>:>9:2=BA?<=>A>847>@C@@3B::=:?7==8=2?@@9<<9';?9?9?>/C>>7>;BC?<@CBC<=>=7:7AAB94;>5=;66A5<><=??3=;A1<:6:1257-=;8:580>?9>:>6?>>><;??8:<3:7602:?<492=/>93<:;58$.096<876/<86:;46=8/556>=6;9;;984859<.:86-<935:98>:=8751:9<>==97::<797<=68>;67<9>>9<=:182;.8=?;<98:26/5>;:68%(87)8>;'=8;882;9;:89<879:;=5>594=773;>25<<2:/9179(=856:#345238/650(4498:/5)31.77<4:<7>?8;:=?<72=6:>;<7<:?><=6==:>6=;.==>>822=:>=9<5=2>=<9831>?;=9>?>=87<=?1>>?569?:-<0=4;>:?>>?;:9=;:8>9:359+8-0/<=:>>678<:=;>686==>>:>;357=:8-;<0:58<703999=;>>;59/*:9;8;1858&.?<87<;3>=5>=3::?3:2662%277562:79:;2<==>4;=:99<7-82:=<83=9>?<>=-=98;3849417>>=<>9:>:9<:.97371.5;:+<9;>>?;931;(=>=95>?8;76>1298164(9:8>>=46&839<6>=4=6;;1:2:<5<9?=?>;79??7?=:9<64:1=>>8,9>;?<;/<;:2;4998>66-66:>=2<3939==?<2<;/>??9=787>>>?<7<(73<<9>?=:9<<848$9::=?;8>>??<<93::<9<=9:5>?4895,?;:7:=9>=3>=2:71;>;981<3<<+82200<*=6>=8/7<<:?:=5;>>9/57:98==;3:;9;;7982><?><:>>=6:7::%:=;>=8>;>=98+;:?=4542%97875>?=1=>;=6===9389=01?75;:9/::;:==9><>>:>;7<6=9>:=7<3?94207308'<>:<:?;>9=:58;:>:7,2=>>=>;;>=;8-=<752<<&59=<8=9;<>8;:>=88=>9;:;<<+;?<9>;><;=3=;>3==;?><;>:97>>;>>=96><=2;960<0>>>>9::,8=7=9649>=9=073*1:?7;58<:=:9:=>7;9=88=;?>>=?;??7>=6>99=<5>>;><6?9,= @rCer/2293/25_2098_CCS ATGGGAGAGCAATGCAGCACCGAGGAGGGAGAGGGGATCCACGCTATGGTAAGCCAAGAGGAGGAGAAGAGGGCAAAGGGAGAGAGAAACGGAAGGACTTACCCAGAATATCAATTGAAGAGGAACATCATGTACTTCAAGCAGCAGAGGCAGCCCCTGGCATGTTGCACTTCTTAAATTCTAGGAGGAACACAAAGGACAGGTCCAGGGCGTCAGCTCGCCTCCGGCCGCACTGGCCGCTCCACGCGAGGCAGAAGGGCACCGGGATCCAGGCTCCCTGGGCACACCTCTCCCAGCCCAGCCCAGCCCGGCGCTGAGCCCACCACTTGGCCGGCGCTCCGCTTCCTCTCGTTGCGCGACTTTGCGGAGCTGCCGCCGGCCCTGGCTGCCCCGGCGCGCGGCGGACAGTGCCGAGGGATCCGCCGCAGCTGCAACCGCTGGGCTTTCCCTGCGAAATCCCGGCCCCGACTCGCGACTCTGAATCGCCGGGAGCCCCCTCCCCGGGCCCTCGGCCCGCCCCCTGCTTTGCATTCGACCAATGGGCGCGAGGCCCTCCCGGCCCCGCTGGGGAGCCACCCCTCCCCACTGACACACTATCTTTAATGGGATTAGCGTTCTGCTGTGTGCCTAAACAAGTGCGCCGCGAAACCCTCGCTAAATGTCAAGGGCTCTGCAGCTGAGGGTGAACCAGAACCTTCAACGCAAAGCGCTGGTGTCTTTTACCCGAGGAAGGGAGCGGCGAGAGGAGGGGGATGCTGGAGGTACCCACGGCCCGAGCAAGCCAGAGGAAAGGTCTGGGGAGGACTGGACGGGGACAGAAGCGCGGCCGCTGTCGAGCTGGCCGCCGCCCCCTATGCACGTGGGGCCTGTCCGGCAGGGCACGCGTCTCCCGGATAGACCTACACACACTCTCTCACACACACGTCCCCATGCTTTGCACACGTGGGTCTGGCTAGGACGCACAGGGAGAAGGGACCGCAGGGAGGCGCGAGGTATCGGAAAGCGCTGGGGCCTCCACGGGGTGCGCGCCGCCCTCCCGCCCCCTCGGCGCGCACGCACGGGCGCGCACACACGCGGCTGCGCCAGGCTCCTGCAGCTGCGCGAACCCTACCCCCGCGTTCTCGGTTGGGACGCTGCGGCGGCTGGAACCCCGGGCAGGCTGACAGGGGCAGGTGGACGAAGCCGGGTCCTACCTTGCCTTTCCTCACGCCTCCTGTGCAAGAGTGATGTAGGGTGCTCTTGGCCACTGTCTGGGTGCTCTCCCATGAGGTCAGAGAAACAGCAGGAGAATGCTTTTGCTCCGGGCTTGGGAACATCCTACCGTAAAACACTGCAACTGGGCAGCCTCCCTTGGCTGGTGCAGAAGTCTGCATTGCCGACAGGGATACCACATTTTGCAAATGATGAGGATTAGAAGACTTGCAGGTGGGGAACCCACCTCTCTTTTGTGCTACCCTTCTAGTCGCTCAGGAAGAGAGTACTGAAAGCACCGGAGGGCAGAGCCACATTTTACCAGGTTCTGTAACCCACCCCCTACCACAGGGCTTGGCCTCTGGGAGACGCTCACTGGGGATGGCTGGATGGACGAATTCATGTCCTACCTGGGCTGTGGGTGTGGAAAGTCCTTCCTGGATCCCAGCAGGTATCATGTCACACTAGAACTGTGTGCTAAACCCCGGGTCAGGCCCTTGAAGAAACAGATATGAGAAGTGGGGCTCCCTGCCCTTCAGGCAGCCACAATCCAGTTAGGAAGACAGGAGGGTATTAATCACCACGGCAGCACAGACGGGCAGACACAGAGCTACCACAACAGGCATGGCCATCTGGGAGGGGACATTAATTCCAGCCAGAGGGACTTTCAGACCCTCATCACAGAGCTGTGGTGGTGACCTGTGCTGGTGGTGACCTGTGCTGGTGAGCCTGCAGTGTCACTGGCTCCCTGGCAGGCCCGCCTCCCAGAGTGAGAGCTCTCCCATTCTGAGTGCAGCTCCCCTACTTTAAAGGAACTGCAGTGGTTTTACCATCCTGAGCCCTTTCCCAACTCAGATGGGGAGCCAACAATAAAAGCTAGTG + 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@rCer/2294/2058_60_CCS ATGGGGGAAGCTGGGCCGGGCCGCGTTGGGCCTGCTGCTGCTGGCGCCGTCCGTGGTGCAGGCGGTGGAGCCATCAGCTGGGACTGGCCCTGGCCGGCGTCCTCACCGGCTACATCTACCCGCGTCTCTACTGCCTCTTCGCCGAGTGCTGCGGGCAGAAGCGGAGCCTTAGCAGGGAGGCATTGCAGAAGGATCTGGACAACAAGCTCTTTGACAGCATCTTGCAAAGAAAATCATCTTAAATGCTGTGTTTGGTTTCATAAACAATCCGAAGCCCAAGAAACCTCTCACCTCTCCCTGCACGGTGTGACAGGCACCGGCAAAAATTTCGTCAGCAAAGATCATCGCAGAGAATATTTACGAGGGTGGTCTGAACAGTGACTATGTCCACCTGTTTGTGGCCACATTGCACTTTCCACATGCTTCAAACATCACCTTGTACAAGGATCAGTTACAGTTGTGGATTCGAGGCAACGTGAGTGCCTGTGCAAGGTCCATCTTCATATTTGATGAAATGGATAAGATGCATGCAGGCCTCATAGACGCCATCAAGCCTTTCCTCGACTATTATGACCTGGTGGATGGGGTCTCCTACCAGAAAGCCATCTTCATATTTTCTCAGCAATGCTGGAGCAGAAAGGATCACAGATGTGGCTTTGGATTTCTGGAGGAGTGGAAAGCAGAGGGAAGACATCAAGCTCAAAGACATTGAACATGCCTTGTCTGTGTCGGTTTTCAATAACAAGAACAGTGGCTTCTGGCACAGCAGCTTAATTGACCGGAACCTCATTGATTATTTTGTTCCCTTCCTCCCCCTGAATACAACACCTAAAAATGTGTATCCGAGTGGAAATGCAGTCCCGAGGCTATGAAACTAATGAAGACATTGTAAGCAGAGTGGCTGAGGAGATGACATTTTTTCCCCAAAGAGGAGAGAGTTTTCTCAGATAAAGGCTGCAAAACGGTGTTCACCAAGTTAGATTATTACTACGATGATTGACAGCCATGATTGGCAGCCGAGTCTCTGCTTGGAGTTGGAAAAGAACAGTCGTTTCACGCCTCCTCCCCAGCTCCTTTCCCTGAAGAGGAATCAGAGTGAATGTTTCCTGTTTGATGTGACAGGAATTCTGTCCCCGGCATTGTTTCCACCCCCTGGTGCCTGTAGGCCACCGAGGGACCATGGGCAAGGACATGAAGCTTCCCCAGCCCGCACAGAAGGAAGGAGCCAGCTCCCAGCCACTCATCGCAGGGCTCATGATTTTTTACAAATTATGTTTTAATTCAAGTGTTTCTGTTTCAAGGAAGGATGAATACGTTTTATTGAAAATATAGTAACTTTATTTAAAATGATTTTTAACATTATGAGAGACTGCTTAGATTCTAAGTTGTTGGCCTTGTGTGTGTGTTTTTTTAAGTTCCCGTCATTATAACATATACTGTGATGTATCTTTACTGGAAATGAGCCCAAGCACACGTACATGGCATTTGTGCCACAGGAGGGCATTGCTGGGATGCGGCTGGAGCACGAGCCAGCTCTGTCCCAGGATGTCCCAGCGGACGCTGTCAGGGCAATGAAGTGTTTAGATGAAGGACAAGTAGGTAAGAGGACGCCTTCAGGCACCACAGATAAACCTGAAACAGCCTCTCCAAGGGTTTTAACCTTAGCAACAAAGGAGCTGTGGAATGATTTTGGCAACACTGTCAACATTTGTTAGAACAAGTCTTTTGAAAGAAAGTATTTCCAGTTTGTCACTTGCCACTCTATTTGCAAAAGGTGGCCTTCACTGTCCATTCCGAATGAGCCACACGTGCCCTGCTGGATTCTAATTATGTGAATTTTGCCATATTAAGTCTTCCTCATTTATACTAGTTTTTGTTACATTCAGTCAAATCCCCGAAACCTCCTATAAAGCTTAGCTGCCCCTTCTGAGGATGCTGAGAACGGCATCTGTCTTTATAAATGCAAATGGCTACCGTTTTACAATAAATTTTGCATGT 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@rCer/2295/1918_56_CCS GAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGACGGCAACAGAGTGGCATAGACACTCCGAGCAGCCTCGCCGTCGCCTCTGCGTTCCTGTTGACTGCCTGGGTGCCCCTCCCCTACTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTGGAGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGTCGCCTGTTTGCGGAGGTGCGGAGAGACTCCTTGGGGGTCTAGCACATAACGGAGTTCGGGTGTCTCGTGTGTGAACATCACAGGGTTTGTGGATGCACTTAGATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACTCATGAGCATAGTGATCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGAAATGGCTGCAGTTCAGAACCAGAATCCGTAGAAGCTAGCCTGTGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTAATTACCGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCAACACCTCCGGCTTCCCTCCTCCATCAGTCCTTATTAGCAAAAACGAAGTAGGCATATTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATATGTGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCGCGTTTGGCAACATATGACTGCATGGGATTGATAGGCAGCATATTCCTGATACATATCTATGTGAACGTTGTCAGCCTAGGAATTTGGATAAAGAGAGGGCAGTGCTACTACAACGCCGAAAAGGGAAAATATGTCAGATGGTGATACCAGTGCAACTGAGAGTGGTGATGAGGTTCCTGTGGAATTATATACTGCATTTCAGCATACTCCAACATCATTACTTAACTGCTTCAAGAGTTTCCAAAGTTAATGATAAAAGAAGGAAAAAAAGTGGGGAGAAAGAACAACACATTTCAAAATGTAAAAGGCATTTCGTGAAGGATCTAGGAAGTCATCAAGAGTTAAGGGTTCAGCTCCAGAGATTGATCCTTCATCTGATGGTTCAAATTTTGGATGGGAGACAAAGATCAAAGCATGGATGGATCGATATGAAGAAGCAAATAACAACCAGTATAGTGAGGGTGTTCAGAGGGAGGCACAAAGAATAGCTCTGAGATTAGGCAATGGAAATGACAAAAAGAGATGAATAAATCAGATTTGAATACTAATAGTTTGCTCTTCAAACCTCCTGTAGAGAGCCATATACAAAAGAATAAGAAATTCTTAATCTGCAAAAGATTTGCCTCCGGATGCACTTATCATTGAATACAGAGGAGTTTATGTGAGAGAACAGTTTGAAGCAAATGGGTATTCTTTAAAAGACCATACCTTTTTGTTATTCTACTCTAAATTTCATGGACTAGAAATGTGTGTTGATGCAAGGACTTTTGGAATGAGGCTCGATTCATCAGCGGTCTTGTACACCCAATGCAGAGGTGAGGCATGAAATTCAAGATGGAACCATACATCTTTATATTATTCTATACAAAGTATTCCAAAGGAACTGAAATTACTATTGCCTTTGATTTTGACTATGGAATTGTAAGTACAAGGTGGACTGTGCATGCCTCAAAGAAACCAGAGTGCCTGTTCTAAAACGTAGTTCTGAATCCATGAAAATATCAGTAGTGGTTATGAGACCAGAC 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@rCer/2296/0_1345_CCS GCCAAAGTTTGGAAAGATTGCTCTGAATGTTGCAGGAAAAAGGTGATAGTTTGGCATCATGGGATGGTGTTTTAGACTTGCCAGAACAGAACACTATTCACAAAGAATTGCCTGCAGTTTATTGACCAGCTTTCTCAGTGCCAGAGGAGAAAGGCAACAGAATTACTTTTGGATATTGAATCTGTAAATTACCTTTTATTGTAAAATCACGTAACATTAAATATAGCACATCCCTTAGCTGGATACATCTACTCAAACCATTGGTGCATCTTCAACTGCCACGCAGCGATTTATACAACTGCTTTTTATGCCATATATGAATAAGTACATTCCCAGGGATTGTTCCCAGAAAGGGAGACCATTTCATCTCTTCAGGTTGCTCATTCCAATACCATGAGCCTGAGCTTTGTTCTTATCTTGATACAAAGAAAATTACTCCAGACTCCTATGCACTCAACTGGGTAATAAAGTGAAAGTAGGAACATTTAATGAAAAATAGATTTATATTAAAGCTATACTTAGGTGGGTTTTTTTTTTCAAGGAAGAGAAAGAAAAGTGCTAAATTATAGATCATTTTTAAACCAAACGGGTAAAAATTATTGGCATTTAAAAAATAACTTTTTTTGCTCTTCAGTTGTGTTCAGATTATTTGATATGAAGTTTACTTTTATTGTTTTACATGTATTTGTAAATGTAACTAAATATTACAACTAATTACAAGTAAATATTACAACTACTTACATATATGTAATAAATATGAATAATATACATGTAATATTATGATACATATATCCATTCAGTTGAGAACTTTGTTTAAATTGTTGATGGTGTGTATAAGAATTTGGTATACAGTCACGAGGAAAATAAACTTTAAGGTTATCAAGTGGTTAATATAAAAAGAAATATAAAGTATAACTCAGCACTCTATCATTCTGTATTTGTATTTTCAATGGGAAGTCTTTACCTTAGGTCAGTGGTCCTCAAACTTTTTGGTGTCAGGACCCTTTACACTCTTAAAATTTGTTGATAAATCCATATGGATTATGTTGAGAAGAAGTTAAAACTAGACTAGGCGCAGTGGCTCACGCCTGTAATACCAGCACTTTGGGAGGCTAAGGAAGGCGGTCACTTGACTTCGGAAGTTTGGGACCAGCCTGGCCAACATGGCGAAACCCCAACTCTACTGGAAATGCAAGAATTAGTCGGATGTGGTGGCGTGTGCCTGTGTTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCGGAGCTTGTAGTGAGCCGAGATCGTGCCATTGCACTCTAGCTTGAGCAAAAGAGTAAGACTCTGTC 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@rCer/2297/25_3305_CCS ATGGGGTTGCCGGTAGCGGGTGTGGGGGCGCGAGCAGCGCAGGGCGGCCTCTCCCCCACCCCTCAGCCCGGGCCCGGGCCCGGTCCCCCCCCTCTCCCTCCACTTCCCACCCCCGTCGGGTACGGGAAGGTCCAAGTCGCTGCCGGGTGCCCGAGGGCCGTCGTGGCCGCCGTCGCCACGGGTCCCAATGGAGCCGCCGAATCTCTATCCGGTGAAGCTCTACGTGTACGACCTGTCCAAGGGCCTGGCCCGGCGGCTCAGCCCCATCATGCTGGGGAAACAACTGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCAGTGGTGGTATCTCCAGCTGCCCCCGGGGGGGACATTGCTTGGGCCCCCAGACTCTGTGGTTGACGTGGGGAGTACAGAAGTCACAGAAGAAATCTTTCTGGAGTACCTGTCCTCCCTGGGGGAGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAACTGTAACACCTTCAGCAACGAAGTGGCACAGTTCCTGACTGGGCGGAAGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGACAGGCACTTCGGCCCCTCCTGGACTCCATTCAGATCCAGCCTCCGGGAGGGAGCTCTGTGGGCAGACCCAACGGCCAGAGCTAACAGGACTGCCTGGGACCGCCCTGCCTCACCAGGGTTTTTCCTTTTTAAAACAAAACAAACCCTACCAGATTTCTATTTTATAATTTTACATCAGAGCTAACAACCAAGGGACGGCTTTTTAAATTTCCCAGGGAAGGAGACTGTCAGGCCGCATGTAGACAATGCTGCTAAGAAACAGAACAAAATGCCACCCCTTCTAATAGTATTATACTAATTTATTAAGGCTGTCTTGTCTGTGAGTTCACTTCGGATGCTGTTTCCTAAGCGTCCACCACACTGGAGAAAGGGAGGGGCTTTGTTTAAACAGAAAGCAAGAGTCACAGTTTGCGGGAGCCCCAACCTAGAACTCTTTCCAGAGAACACTCACGCTCTACCCAAGTTGCACCACCTGTGGGACCCAGGTGAGTTTTAGAACATCCGTGACCCGGAAACAGTTACTCTAGTGTTAATGAACCAAAGGATTTGGTGCACATGGGACCAGTTTCAGGATGACTAACCCAACCTAAGTGAACTCTTCAGCCACAACCCTCCTCACCTTCCCTCCCTTACCACAAGCAAGGCCAGTGCTGGAGCAGCCATTGCCTCAGGATCAAGGGAGTAACAGCAAGTATCAGGCTGGAGAAAACAGGATAAAGCCATTTCCTCCTTCCACCTAGATGGATTGCCAATCCTCTGCCATCAATTTTGGGAAACCTGCCTTGGTGCCTCCGAGGCTGCTTTTCCTCAGCATAGCTGATGTGTCATAGTTGATGAGGTCTGGGCTGGAGCAGCAGGGACCCAGGCCTTTTTTTCTACAAGTAATGATGTAGGTTATTTTGCAGTCTCTGTAACCACCATCCAGACCAGTATGCAGTATTCAGCTGGGGACCAAGGGACGGGATTCCCTGCTCTAAGAAAATACCTTTTTTTAATTATTATTATTTTTTGAGAGCTCTGTCACCCAGGCTGGAGATTGCAGTGAGCCGAGATTGTACCAGTGCACTCCAGCCTGGGTGGACAGAGTGGGACTCCATCTCAAAAAAATAAAATGATGTGGAATCAAGGTGGCAAGAAAATTTAGAATCATTTCTGATAGGGACTTTCCCTTATCCTAAATGTGTTTTGAAGGCACAGATTATTTCCGTTGTCATTCTGACTTTAGGGAAAGCAGGTTGGGGCATGAGTGGGCATTTTTCCTAATGACTTGCTGCTAGCAGTTTATTAGGCAGGAAACAGTCTGGGAGTCTCTAATCCAGAGAGACTTTCAGATTCCCTCTCTTCATGTGAACCTCCATTAGTTAGATTTTGGGAAAGTGAGTGTGAAGAAGGGACTCAGAGCTGCCAGGTACCCCAAGTCTCAGCTCTGACATCCTTGGGCCCCTTCTGCCACAACTTCCTGCCACCTCGCGGACTTGAATTATGTTGCTTCTTCCTGGAAGTCTGGCCTGCAGCAGGGGCCTTTCCTCTCCAAAAAGCTGCTACTCACTTCTGGCCCCATCTGCTGCTATCTGCCATTAGCCATAGCAGTTGGCATCATCAGAGTCTCAGCTAGAGGAGATGTCATTCTGCCTTAGTGTTTGCCTGTGACCTGACCAGGGGCATGACCAGCTGGGATGTCAAGTGACATTTTGGAAACTTGAAGATTACAGGCCAAAATGAGTGAAAGTTTAAATTCTTCTCAAGACCCACTGATTTGCCAATGTGCATGGAAATAATAAATTAGAGCAGAAACCAGCAGGGACTATTGTATAATTGGTGATCTACTGGCAAGAACTGGGCCCAAAGAGAAAGAATTTCTCAGGCTGGGTTCTTCTGGAGGGTAGCAGGTTGGCCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTCCCCCTTTTCCAGCTTGCTTGCCCGGCTCTGCCTTGCAGGCTCCTGCTTCATATCCCTCTGCCTGGGGTCTCCCTTCCATGCAGGGGGTTCTGGGCATCACAGCTCCTTTTTTTCTTTCTCCTCTCCCAGATCCAGTTTCAGCTGGTTTGCTTCTCCCAGCAGGTACCCTTAGGCCCAGGGGCAGCTCCCCTGAGAGAATTTGAGGCACTCATGTCCTTGAACAGCACCCCCCTTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGGTTTGTGGGGAGAGATCGAGGGATCAGTGAGCAGTTTTCCAGAGCTCCATGTCAAGGCAAGCTCTCCCTCCCCTGATGGGAGCCCCAGTGTCACTAACTGTGTAAACTCAGGCTCAGGCTTCAACTGCCCACCCCCATCCTCACATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTTCATTGTGGCCAGCTAACTCCACCTGGATGTGAACAGGCAAGCAGAGTGGGAAATGAGTCACGTACTTGTATCGCACAGTGTATCGGACACCTCCCTAGAGGTCCATTGGTTTAAAGAGATAGGGAAGGAGGAGGGATGAGACCATCACCCCCTCCCAGAAGTAAATCTAGGTTTTCTTTATGGGTTTTCTTTTATGCCCTTGAGTCAAACTAATAACTGTGTCTAGGACGGAGATGTTTGCTGGTTTTCTTTGGTGTTTTTTCTAATGCAATAAATTCATTTCTGCCTG 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@rCer/2298/1459_58_CCS TTATTTGAAAGTTGAAATTTATGAGCTTTGAAGATTGCAAAATTAAATAATTTATAGCTCCAAAAACAAAAATATACTTGTATATGTCACAGAAAAAATGCAAAATTTATAATAGAGTTACATTAACCTTGTTGTTTACCTTTCACTGATTTCTTACATGGTATAAATTAAAGTTCAGGCATTTATGGGGAGCAAAGGCCCTCCCCACCACCCCGCCACCTGCCACCTCTGAGGGAGTGGGAGAAGTGAGTCTGTGCCAAGATAGTACTGAGTCCTCAGATGTTGTATACTGTAAATTATGGTATAATGCCAAATGCAGCAAATCTTCAGCTATACCTTACAAGTTTGGTCATTTTGAAGCTTGACGTTTTAGTTTGCCATTATGTTAAAAACATCTAAATAGGTGTTAGTTTCTCAGGAGTAGATTGTTAGTGTTGACTTTTCCTGTAAAACAAACATCGTTCTTGGCCTGCCTTGCATTGTATACTAGACTTCATTGTTGCCTCTCATGCTTCTTGAGTTACTTAATGATTTATGCTAGCCATGGAAAGCTATCAGTAACAGTTTTCACGCTTATACCAAAGAATTAAATCTGATCCTTAATATCTGATATTTTGCTGGTACTTGTACTGATAAGTGATTATTGGAAGTCAGTCACAGAATTTGAAAATAAATTCTAGTCTCTCCTTAGCTATTTGATGCTTTTCATATAGGCCAAGAACCCATTGCAAACATTTTTGCAAGTATGAATGCCTGTATTTGGTCTAGGAACAGTACATTTTAGTCTGATTTAGAATTACTGGTAGCTTATTTTAAAGCAAGGAAAAGCAGCTGAGCTCGAGTTTGCTGTCTTTAGAACGGTTTGTGAAAATATGGTATAAAAGTGTTTTCATTTTCCTGTTCTTACCTATTGTATAGAGCTATTAATGCATTTTTTGGGAAAACCTTAAAAATTGCCCCAAATACTGACATTGAGTGCATCAAATAACAAATTGTCTTTGGTATATTAAACTTTATTCTTCATGCATCTGTAATTTAATTTTAAGTATAATGTTTGCCTTTGGTACAACTAAATTAAAACTCTTGGTGGTCACATGTATATAAACAAAACAATATGCTTTGTTGAAGGAAATTTTCTTTATTGGAATGTGGTTGTAATCCTTGTTCAGTTCTTAAGTTTTGGTTTTTTTAAAAAACAGGATGCAACTTAAATTTTCTTTGCATCAAGGTATATGCAAAACATTGATGCAGTGCATCACAAAATGGAAGTTTGTATTTAATGAGGAGGTGCTTTACACTGTACTTTTTGGTGTTTTTTGGAAAAGTTACATTTAGATCTATTCTGAAGCTGTTCATTTTTAACAAATAAATGTTACAGGTTTCAATGATTTATTCTTAGCT 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@rCer/2300/2236_57_CCS ATGGGGGCGCGTCTCCGCCGCACCTCGGAGACAGGAGCTACTCGCCCGGTCCTGGGCGTGGGAGACGGCGGCGGCTGCGCTCGCGCACCTCGGAGGAGCCAGGAGCCGGAACCAGGGCCAAGCCTGAGGGCCGGGGCGAGCCAGGCGGTTGAAGATGTCTGCCCAGAGGTTAATTTCTAACAGAACTTCCCAGCAATCGGCATCTAATTCTGATTACACCTGGGAATATGAATATTATGAGATTGGACCAGTTTCCTTTGAAGGACTAAAGGCTCATAAATATTCCATTGTGATTGGATTTTGGGTTGGTCTTGCAGTCTTCGTGATTTTTATGTTTTTTGTGCTGACCTTGCTGACCAAGACAGGAGCCCCACACCAAGACAATGCAGAGTCCTCAGAGAAGAGATTCAGAATGAACAGCTTTGTGTCAGACTTTGGAAGACCACTGGAGCCAGATAAGGTATTTTCTCGCCAAGGCAACGAGGAGTCCAGGTCTCTCTTTCACTGCTACATCAATGAGGTGGAACGCTTGGACAGAGCCAAAACTTGTCACCAGACCACAGCCCTTGACAGTGATGTTCAACTCCAGGAAGCCATCAGAAGCAATGGGCAGCCAGAGGAGGAGCTGAACAGGCTCATGAAGTTTGACATCCCCAACTTTGTGAACACAGACCAGAACTCCTTTGGGGAGGATGATCTTCTGATTTCTGAACCACCTATTGTTCTGGAAACTAAGCCACTTTCCCAGACCTCACATAAAGACCTAGATTGAGAAACATGCTCTGTAAAGGGTCTTCCTGAAGATGTGGATTCTATCTTTATATGGCAAGAAATCTACACCCACCAAAATTGTGTGTGTTTGGGGGAGAGAGAGGCACAGAGATAGAGACAGAGAGACAGAGAAGAGACCCCTTTAGAAGAGAGCTGAGCTGATTAAGCTGAATGGTTTTTTGTTTTGCTTTGTTTTTGCTTTTTAATACATTTGGAGCTTTGGTGGTATTAAAGTATTTACAACAAGCTTGTCCAACCCATGGCATGTGTCCCAGGACAGCTTTGAATGTGGCCCAACACAAATTTTAAACTTTCTTAAAACATTATGAGATTTAAATTTTTTTTTTTTTCCTATTTTTTTTAAAGCTCATCAGCTATCGTTAGTGTTAGTGTATTTTATGTGTGGTCCAAGACAACTTTTCTTCCAATGTGGCCCAGGGAAGCCAAAAGACTGGACACCTCTGATTTATACTAGCTCATCTTCCTTGTTCAAAAATTTGGCCAAATAGTTATTGTCAGCATTCTTGGGTGAGGATTAGCCTACCACGTTCTAATCTGGCCCTGCCACTACCATGCTCTACCTTTAGCAAGTTGGTTTACCTCTCTGGGCTGCCCCATTTTTAACTGTAGGTTGACGTGTCTGGAGTGATCCATCCCACCTCTAATATTTTGTGAATTTATGACTTTTGCCTTCAGATGAGGCTAAGCTATACACAAAACAGTATAAACTAGGGTACTGCCTCATACCTCTCGTAGGCTCTCCCAAATCTCTGTACCTTCCACTCAACCCTTAATTGAACCAAGCTTTAGTCAGGGGGTCTGAGTATCTACCAGAATGTCAGGAGACTCATCTTGCACAGTCACGGTGGCCAGTGTTTCTGGTGGGTTGTGCTGAAACAGCTCTTCTGAGAACTTCCAACCACTCATGCTCTAACCTGGGGACAGCCATCCCGTGCCTCAGAATAAGTACCAATTCATAGGTCATGCATGGTACTCTTGTCCCCAAGAAAAGTTAGGAAGGTTGTCAGCTGAGTGAGGGGAGGTGCCTTCTGGGTATCTCTGTGTTGGTGTATCTGTGCCATTGACTACAGAACAAGAAAAAATACTATTTGCCATGCTATTACCTTGGCAGATGTATGGGTGATAGTCATCTGTATTTGAGTTGAGATGGTCAGTGGGTTGTAAAATTCCCCACTAGCAGATATTCAGGGTGGCCTGAGTTACGTAAAACATGTGAGCAACACAGATTTAATTTATGGAGGAATCAAAGCTGCAGACTGGTGTTAAAACAACTTGGTTTTGTGCACACAGTTGCATGCATGGCAAGCTGTTAATCTCTGGGTGGCATTTTCATTATGAATTTGTTCACCACCTGTCTTGCTTAAGCTATAAAATAAATGCATTTGAC 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@rCer/2313/25_2176_CCS ATGGGGAGAGCGGCTGATCGTAGTCCGGAGGTGGTCCATTATGGCTTGACATGCAAATCTGGTAGAAAGATTGGAGAGGGCAGTGGGCGCCTGGAGGCAGTGTCCCATACCTCTGACATGCACCGTGGGTATGGAGACAGTCCTTCAAAAGCAGGAGCAGCTCCGTATGTAGGGCATTTGACTCACTGCCTTGCTGGTCTGTGGCAGAGTACTTGAAGATCAGTAAAGAGATTGGGGGAGACGTGCAGAAACATGCGGAGATGGTCCACACAGTTTGAAGTTGGAGCGAGCTCTGTTGTTACAGCTTCTCAGTGTCAACAGCCAGCAGAAATAAGCTTTCCGATTTGTTGGCACCCATCTCAGAGCAGATCAAAGAAGTGATAACCTTTCGGAGAAGAACCGAGGCAGCAAGTTGTTTTAATCACCTGTCAGCTGTCAGCGAAAGTATCCAGGCCCTGGGCTGGGTGGCTATGGCTCCCAACCTGGCCTTATGTGAAAGAAATGAATGAGCTGCCATGTTTTATACAAACCCGAGTCCTCAAAGAGTACAAAGATGTGGATAAGAAGCATGTAGACTGGGTCAAAGCTTATTTAAGTATATGGACAGAGCTGCAGGCTTACATTAAGGAGTTCCATACCACCGACTGGCCTGGAGCAAAACGGGGCCTGTGGCAAAAGAACTGAGTGGACTGCCATCTGGACCTTGCTGGATCAGGTCCTCCTCCCCCTCCGCCAGGCCCCCCTCCTCCCCCAGTCTCTACCAGTTCAGGCTCAGATGAGTCCGCTCCGCTCAGCACTGTTTGCGCAAATTAATCAGGGGGAGAGCATCACACATGCCCTGAAGCACGTATCTGATGACATGAAGACTCACAAGAACCCTGCCCTGAAGGCTCAGAGTGGTCCAGTACGCAGTGGCCCCAAGCCATTCTCTGCACCTAAACCCCAAACCAGCCCGTCCCCCAAACCAAGCCACAAAAGAAGGAGCCAGCTGTACTTGAACTGGAGGGCAAGAAATGGAGAGTGGAAAATCAGGAAAATGTTTCCAACCTGGTGATGATGACACAGAGCTGAAACAGGTGGCTTACATATACAAGTGTGTCAACACGACATTGCAAATCAAGGGCAAAAATTAACTCCATTACAGTAGATAACTGTAAAGAAACTTGGTCTGGTATTCGATGACGTGGTGGGCATTGTGGGAGATAATCAACAGTAGGGATGTCAAAGTTCAGGTAATGGGTAAAGTGCCAACCACATCCATCAACAAAACAGATGGCTGCCATGCTTACCTGAGCAAGAATTCCCTGGATTGTGAAATAGTCAGTGCCAAATCTTCCGAGATGAATGTCCTCATCCTACAGAAGGCGGTGACTTTAATGAATTCCCAGTTCCTGAGCAGTTCAAGACCCTCTGGAATGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAAGCGAAGTGCCACTGGGTTTCTTTGCCCTCCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTTCTAGATTTCCTCTACCTTTCTGCTCTTAAACATGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTTGGGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGACTGATGATGCATTTTAGCTTTGAGCTTTTGGGGGTTATTCTACAACAAACAAACAGTCCATTGGAAAGAAACAGTCCCAGGAATTAACAGATCAGAATGTTCACACTGGTTAATCTTTTTCTAACAGTGAGCATGAAGGTAGCAGAAGCTGGTGTGTTTCCAGATGGTTCTTTCTAACCAAACTAATTTTCACTGTTGACAAGTGAGCAAGGGTTGCACTGGACCGAAGGCTGAGGCTTGGCCATCTAGCATTCCTGCAGAATGGTTTCCCATAAGCATTCCTTTTATTCTCTGTTCTATCCTGGTCTGCCTCAACCATGAGATAGGAGAGTCTCCGGTACTAGCTGCTATCCAGGGCAGTTAATGGAGTCTTCAACCCTTTCTTTCTCTGGATCCCTGACTAGCACCTTCCTATAGAGATG 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@rCer/2314/25_1559_CCS ATGGGGATTCTGGCGCGGAGCGGAGCGGCGGCGGGTGCGGCTAGCGGGTCGGCCGCGGAGCGGAGGTGCAGCTCGGCTTCCCCCGGCACCCCTCCCCCTCGGGCGCCAGCCCCACCCCTCCGCCGGCCGGGCCAACCCCGCCGTACTATCCCCTGCGGCGCGAGCCCGGGGCGGCTCCGAGCGCCCCCAGCAGACCCCCATCATGGGCAGCCAGAGCTCCAAGGCTCCCCGGGGCGACGTGACCGCCGAGGAGGCAGCAGGCGCTTCCCCGCGAAGGCCAACGGCCAGGAGAATGGCCACGTGAAAAGCAATGGAGACTTATCCCCCAAGGGTGAAGGGGAGTCGCCCCCGTGAACGGAACAGATGAGGCAGCCGGGGCCACTGGCGATGCCATCGAGCCAGCACCCCTAGCCAGGGTGCTGAGGCCAAGGGGGAGGTCCCCCCCAAGGAGACCCCAAGAAGAAGAAGAAATTCTCTTTCAAGAAGCCTTTCAAATTGAGCGGCCTGTCCTTCAAGAGAAATCGGAAGGAGGGTGGGGGTGATTCTTCTGCCTCCTCACCCACAGAGGAAGAGCAGGAGCAGGGGGAGATCGGTGCCTGCAGCGACGAGGGCACTGCCCAGGAAGGGAAGGCCGCAGCCACCCCTGAGAGCCAGGAACCCCAGGCCAAGGGGGCAGAGGCTAGTGCGGCCTCAGAAGAAGAGGCAGGGCCCCAGGCTACAGAGCCATCCACTCCCTCGGGGCCGGAGAGTGGCCCTACACCAGCCAGCGCTGAGCAGAATGAGTAGCTAGGTGGGGGCAGGTGGGTGATCTCTAAGCTGCAAAAACTGTGCTGTCCTTGTGAGGTCACTGCCTGGACCTGGTGCCCTGGCTGCCTTCCTGTGCCCAGAAAGGAAGGGGCTATTGCCTCCTCCCAGCCACGTTCCCTTTCCTCCTCTCCCTCCTGTGGATTCTCCCATCAGCCATCTGGTTCTAAGGCCAGTTGAAGATGGTCCCTTACAGCTTCCCAAGTTAGGTTAGTGATGTGAAATGCTCCTGTCCCTAGCCCTACCTCCTTCCCTGTCCCCACCCCTGCATAAGGCAGTTGTTGGTTTTCTTCCCCAATTCTTTTCCAAGTAGGTTTTGTTTATCCTACTGCCCAAATCCCTGAGCCAGAAGTGGGGTGCTTATACTCCCAAACCTTGAGTGTCCAGCCTTCCCCCTGTTGTTTTTAGTCTCTTGTGCTGTGCCTAGTGGCACCTGGCTGGGGAGGACACTGCCCCGTCTAGGTTTTTATAAATGTCTTACTCAAGTTCAAACCTCCAGCTTGTGAATCAACTGTGTCTCTTTTTTGACTTGGTAAGCAAGTATTAGGCTTTGGGGTGGGGGAGGTCTGTAATGTGAAACAACTTCTTGTTGTCTTTTTTTCTCCCATTGTTGTAAATAACTTTTAATGGCCAAACCCCAGATTTGTACTTTTTTTTTTTTCTAACTGCTAAAACCATTCTCTTCCACCTGGTTTTACTGTAACATTTGGAAAAGGAATAAATGTCGTCC + F=CJKEH7IDG2JJFI:JIGJ@FC@E;GHJHD2BEDDC?962=FFAFDCG9=D::>AC@C@:=0AGEIDHKJIGEI6HKH>?DFE3GG?>&ICFD?D5HJIKEG8H?EHIDC7FJ/CFBAGEDC7AFBDEJ'@>F::?5GE>0:CJJDJII639KFHEDFKGG;HH4IJKEK:A>GKK,JJIGCIIHKJH@C@2ACJHHIIEGFIIIHGHHE>I6IICJBIJKGKCDADIBFF?=0E#@FDGIJIH$HHFGD?6=DI=JECGDFF:A6;BA'?9@ACACKK?BGJJHGFEDGEHEH3CDE=:?BI:FB@ADA/KDEE@8#B=86;B=E@9BF;IF>?HBKDGHDEKDBJE;IG.A8FEGGGH8DEJ=7EI7E-CEEFCHHKFH=1B:9%>DA<<@EBEH>FEHB5EDIHJHH?BIHECBDEK9K?IJIIBKHEHG,EFHE>CFIIFA>D%EEFGFHGIBFAB1>FGFHH?4<>HA0:E5C=>F8G9FII@H>CI2IGEEICFKK:ECCKFK(CCJI@J@H>K&JADJIJ>G:@9BBFKFE=F9<@H9?5CGBFFD@HHKDEI3ACFCCJ?GG=CDGB5KIF@G;?1-CHGI)DFG4FEIEEFHF=I:FGICGDDHB?CAEBBECGADC=DC:C8B?DEEEC<>?B<3;AEJGB;ECC>DAI@AHCD@CDGACFB6EGFB@>GAGEABEIJ=ED>HDBIAHFHHE@GCAJ9DCGHJ>E5@:@ACEGICE2C8HFGBHE=DDEI5BF@FCBJIIACAGI0JB?FFCI;BC?DEEHEBFIAH@DGIBHGFJIID9IG?DI:JBAB<8FB@DB=E?>CBEEEFAIFGEDHHC1;E;GFD?CDC.EB3:/<;5=AGCACHFGD>=@6=FGFGF7FFGAF=%D6=;FF?B8GEIGA;@1:4>B<>?BC@)BBA=?D:AI?C@FAEDHH69IJHJ?8HFGIGJKHHJ?@G:J>KIJAKJAJJJJHII(HKJIDFIIFI>GB2I;HJI9=ACIEF9GJDEGIHF/HCA>7JKIFJGC>'8H?DIJ@JJKFIKHJK>J869*40,75=3>45;=6:21,343;/5<78+-756/,42.1::3:9:>=4:87(6<>7722<7:<79>>10690->==;%4:<8118:988)9284<::07;:384(069:;9=:;64554.)/11266+46&55438>:9<6;24824;69668563*'643<<8<64;>8<057=;=7:://6=9316789$446?-6597&9932+8$+.,2678894:;;2;892'8.78.03=<95;75682596=659'9:2;5-<96<;=8;-08?9837/-1$-420,5/,540-/(5/$15664-,03-9/5-4)56454235'60/66649;:98*5::=8;989:8/+5$-8618<789749,/,4,99:#9=::76:388*99<<;;29.256+6367,8+93/-/58+8/:.-+'6,2-3*:45;2*/54=>:958=?;0=;17.55/56<8+8%::8599715/71,:3;17;923<:78260965'7566596/<3.3<8(51/(14869;4892229=?=069=46>.:<:;3/86+6797462.652:;5268.$230.&(..&105,89=<=7,<),/7653272764-,1<<78=972<7:<::783.86.8<9<0001<;9;88;+6.+10517588.1><85>9>;::.1683'/8<7&6<<6:<3=598,::<;98<=;=;74>;9*765+1:0550/<:/95=7-7;28-88666<>>6&71,686467)211:<4:=9510+66/47700.7-88:95=0039;%$)-.<8:0353638.074'08982602496;3092),657/;318862:)-7268>87<6<07401547168-247../+2.0.2+43)/2.1,/82.14'/86.0)+,/)/-3110723.-4.888:=-6'64=7;9<<7<:*36785:32:+8,9:.2929::6<29371818+5889=:-/.;949=8<3696&8:5&84110.//3:7698409768&-10,4002//0/:85,8212.-+<976;886:76053/=5249<;560065'%0378(98/47=;1949,:891821)2>;5=15/340.+-'&201342.0268221+*-/886764/7>76:2'++5+&+4376968./.49=45:;:2=<,-19.577:/789;*8::<076:87<>==7-&6;8=83&0-771:7<@>;@819;?5116=84<)688>84:7*58;;(8==;05$7:@>A@:67;97440244;=5>929?>9:41=?<808;:59;25??8:71963-:7496'3<58/:9*55831506%+,977+8.,:5+610.;/3-27:'1%0(,/540.,-1864,'-334.8>=>303;9552.3;5)2/350*55)/&,-.+718'.,6$45.)6/0-+20/--1.&'%,3,<<571+3#-#)37.)10*,-41,1')6).1--0(6,87368<7-*2.)068796<4198361059696'975996/7;228,559/1:355749758827)&,495$3688.5/2.221;647089.84878<3%---121/,&683*1,,324:'00532+69311975$3-1,9;5/856(1*$(/4)60<68<<;9$,-*(4:3(.484547*49;459$37&&<;66182--*20.30&8716837:/765*;83'/+45,737:=:<99<>:4544929;55:6;795<7/36/-47%69>:17050'1.59490066;/7;+842*45231574.666528677'6447830;/=3=7:<479(/3066;1368148/76:5==<14:5988)3578726943/.*#05726+99;84>1:1656172774;78987+97:5788993)-/%.10946:689$..$%40,-63'288982662.76380143.7/803%5305.57)643061702266834-)59-43)-2666/(06741/2522+/34431&3...,.508,298-,'.8669541'663:56,598399-7.7./733534364/561989263653:253375+450,-0+0.'5.5.79;8-3568687:4-45786535)5246+38:575853-4503354**35356::84)-/5 @rCer/2319/24_1785_CCS ATGGGAGAGCGGTCTTCCGCGGCTGTTTCCCAGGCTAGCTGGGCCTGTACCTCGCGCACTCCTCTGGCTCCTGGTCCTTCAGTCTCCGCTCGTCTCACCGTAGGCTGTGACGACATGAGCAACAAAGAAGGATCAGGAGGGTCAGGAAAAGGAAACATGACAATTTCCACATAACCAAAGAAGAGAAGGGAAGGATGTTAATTCATCTTCACCAGTGATGTTGGCCTTTAAATCATTTCAGCAGGAACTTGATGCAAGGCATGACAAATATGAGAGACTTGTGAAACTTAGTCGGATATAACCGTTGAAGTAAAAGGACAATTTTTCTCCTCCATAGGATTACAAGTGCTCCTGATATGGAAGATATATTGACTGAATCAGAAATTAAATTGGATGGTGTCAGACAAAAGATATTCCAGGTAGCCAAGAGCTGTCAGGGAAGATATGCATCAATTCCATCGAGCCATTACTACAGGACTACAGGAATATGTGGAAGCTGTCTCTTTCAACACTTCATCAAAACACGATCATTAATTAGTATGGATGAAATTAATAAACAATTGATATTTACGACGACGACAATGGGAAAGAAAATAAAACTCCTTCTTCTGATACACAGGATGAGCAGTTTGGTACTTGGAGACTGAGAGTCACACCTGTCGATTACCTTCTGGAGTGGCTGACTTAACTGAGAATTGATGCGGATGTGTATTAACAGTGTGGGAATGGGACATTGACACCCCTTTGAAGTGAGCCAGTTTTACGTCAGGTTTATGATGGGTTTCATTCATTGGCAACACTGGACCTTACGAGGTCTCTAAGAAGCTGTATACCTTGAAACAAAGTTGGCCAAAGTGGAGAATGCTTGTTATGCCTTGAAAGTCAGAGGGTCAGAAATTCCAAAACATATGTTGGCAGATGTGTTTTTCAGTTAAAACAGAAATGATAGATCAAGAAGAGGTATTTCTTAGAATAACATTACTCAGTTACTAATTCTTTGAGAACTCTAAGAGACCAATTTGTAAGACTTATTTAGTATTCATTTAACTTATGTGGCTTTTACATAGAAACATATTCAGTTGTACTTGTTTAAATTGTATACAAGCTGTACATAAAATTAGCGAAATGAATCATTTCTTATATCTTATTCATGAAAGTTTGCATACAGATGTTTGCATATATGCCTTTTTGAATTTTGCTGGTTAACCTTTATCATTTATCTTTGTAATGTGAACCTGTTTCACAGTGCACTTTTTGCCATAACTATCTTAATTTACTTTTCTGAAGTTTGGAGTGATAATTTTTAGTGGAAGCAATTTGTAATTTAAGTTGGTGATTTTATTATATATAGAAAGATTTTTTAGTTAAACTTCTGGACTTGAGCTTCCTATTTAAATTTCTTGTTAATATTGTGCCAAGCCTCAAAAATAGGTTTATTCCATGGAACAAGAATTAAAAATGAATAAGCTATCAATATATAATTTAATACAAGTTTAGGCTGGCGTGGTGGCTCACGCTATAATCCCAGCACTTTGGGAGGCCAAGCAGGCAGATCACGAGTCAGATTCGCGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGTGTGGTGGCATGTGCCTGTATCCCAGCTACTTGGCAGCTGAGGCAGGAGAATCGCTTGAACCCAGTAGGCAGAGGTTGCAGTGAGCCGAATTGTGCCACTGCACTCCACCTGGCAACAGAGCAAGACTCCAT + ?92@5:89?>8C?5:==?3,)8<)7&::.3;@&>>>@>00,B6-98;CB5EFEAAD;6-0*67)6)@=A:AC3B>8>BCFBF@?C12:D>B;9C/AEBF5@9-C1)HI2F/;;=@(D?74G2:E0CEA@35&:D>I067/H@3GCCEK@@C-7?/HDCFE?1AG1JJKHK>I/J'GI4F@JF%76DDKBEBA5E@5DJ&E*=GI@:@9CDAF:H5>5G@:G?*DABEBD?99*)<4=(EKE/F1JAF;6G:J8KJIC@?992$B@87C@E=:KJFAI-IJG;@@D7;3=+B8H4F2CG>C@KIC7=HF9I-GC-H>A3JAG;;>.IG2KJF4HII8*III%9/=H;7/1;D,<7E@?EIID8G7J4:B>5;AJ8;E:9;CKIE?BE:F999B1552?)>F429A6+E;2>A%DC>EC4GD8>*6CAA>EC?C1>'C=1EBA=C<3F<+F*BAB6/65&..A?6B=57*IJDF92/FA0@5D,DB@::@D7F/F)A6?:D@)86#>DA?CGG>G,;FDC2<(ABBF=:66=@A'D9G8E8BAE3G5F>@;5@2;:/EAB;B>=7G?25<+HHE$D/?@952:GD,B>(A0DD<3GC2=<75FH9BFAFE5@JI;ICE=AD>4<98;@-IIG@:=FCE>7+>-?@F3J38>6BJ2@?F6EH69A??A;6,#EA(7.IFFGBF@5J.?F&&=BGDDI=JH;J=G-FDCACG=G&EC:1EDB78>JFII6CB1A7?(IIDFCB6?B/>6=F<5?>JFBECD2:4I:&?C?@7E;-GF?1FB1:4@6)?;(;99/B2=<;%8:$-7236B;?==.4&3$;9:C?:*95=:C=?:&?:B<;=1E8;/DE(==>9>4;8;@A9+BCE<62:%:;=='9.7;8.B;CC>==7A?@<:B6&;@<;&=&>7706:@,.='>:<>96&4@AB<=7<6)($0:A1B92AAB;CCB+C?4881GB? @rCer/2322/508_60_CCS CCTCCTCACCAAGCTGTTGCAGTTTGAGGGTCGAAATCGGATCTCCGCAGAAGATGCCATGAAACATCCATTCTTCCTCAGTTTGGGGGAGCGGATCCACAAACTTCCTGACACTACTTCCATATTTGCACTAAAGGAGATTCAGCTACAAAAGGAGGCCAGCCTTCGGTCTTCGTCGATGCCTGACTCAGGCAGGCCAGCTTTCCGCGTGGTGGACACCGAATTCTAAGCCACAGACCGAGGCCCCAGCAGGCAGCGGCTGGAGGGATGCCACACCCCTCACAGGGCAGCCCCCAACTACATTTTCCCTGCTTACTCTGCCTACCTGCCTGAGCCATGTTCACCTGCCCACTTGTCCCTTGCTGCCTGTCCAAACACCCGACCATTGGCCTGTCAACCCACCCATTGGCCTGTCTGCTGGGTGCTAACAAAGCTCTCATCACTCCTT + IG@F2EIKKFFBKGKIJ>KKEJKK-KIKKAJAJKK@IIKGAHKIIHJHGIJHJAGIKIFKJKDGK>KKJKJFKKJKHGJGKJKEIKIK7GJKKKJKKE-KJKCKKEKHKIEJKKJDKHEJHD?A?J;KIJJGDIEKJKJDKEFHCCKKHKKK5KCJK>KKKKKJK?JKKKKKJJKKKJGKKKFIKKKGKKKJKHKFKFEGKKK@EB?JJIHDGFADCFK?JIDKCJIGFJHHABIACD8B;CHC>5JH=AFDHJGFHIGGHICBAAIG;IDEG?=KI*>@C7EDFGKKCEDHF;EFEJ:JHI@;=?GGHDJIJDH0IBEHIJ3AH=FGKHGE4@GC:GDI>IIEFDCGDC,CF>9=DG6BFI??>GD @rCer/2323/1570_57_CCS GGCGGCGGCGCGGGTCGTCAGCGGGAGGGCGCGCGGCCGAGCGGAGGCAGAGTCGGCGCCGAGAACATGGCTGGAGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAGGCTAAGCAGTATCTCGCTCACAGAGAGCTGGGCTACAGTTTCCTGTGGGCCGCATTCACAGACACTTGAAGACTCGCACCACAAGCCATGGAAGGGTGGGTGCCACTGCTGCCGTGTACAGTGCTGCGATTCTGGAGTACCTCACTGCAGAGGTGCTGGAGCTGGCAGGTAATGCTTCTAAGGATCTCAAAGTAAAGCGTATCACTCCGCGTCACTTGCAGCTTGCAATCCGTGGTGATGAAGAGTTGGATTCTCTTATCAAGGCTACCATAGCTGGGGGTGGTGTGATCCCTCACATCCACAAATCTCTGATTGGAAAGAAGGGACAGCAGAAAACTGCTTAGAGGGATGCTTTAACCAACCCTCTTCCTCCCTGTCGTTGTACTGTAACTGGGACAGAAGAAATAATGGGGATATGTGGAATTTTTAACAACAGTTAAATGGAAAAGCATAGACAATTACTGTAGACATGATAAAAGAAACATTTGTACGTTCTTAGACTCGAAGTTTGATAAAAGTACCTTTTCATGTGGTGACAGTTGTGTGTTGATTGGCTAGGTTTCTCCGCGTGTTTTATACAAAAATGGAATTGATAAACCATTTTTTACAAAATTAATTTGTCTCAAAACTGTTCTGTTCATGATGTATTAGAAATATTTTACTCAGACTTTAAGTATTTTAAATCTCAGATTGGTTATTCAGAGTAACCTTGGAACAGAAATTGGGAATATAGCTTTACAATGATTGATACCATGGTATATTGACTCTTACATGCTATTGATCTGTAGCACCATTTTTTACAAACCACTAGGAAAAAAACCTGCCAATTAAATCATGATACACCATCAATTATGAGACATCCCAATTTGAGAGGTGTTAGATTATGGAAAAGTGTGCATTTATGACTGAAATGCTAATGGAATTATTTGAATTCTATACTGAGCACTTACCATTTGCCAGGCCCTTTGCTGAGTGCTCTACTGACTAAGAAATTTTATTCCCCCACATTATAGATGTGGAGTCTAAGGGTCACAGAAATTGTATGCTATGCCAAAAAACGTTCAACTAGTAGATAGAAAATGACAGAGCTATGATTCAAACCTAGATCTGGCTGACTTCAGACCCTGATGTTCAGTTTATCAAAGGTTTTTCCTTTTGGTTTAAAATCCCAATTTTGGCCAGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTCGGAGGCTGAGGCTGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGTAAAACGCCATCTCGACCAGGCACAGCGGCTCATGCCTGTAATCCCAGCGCTTTGGGAGGCCAAGGCGGGCGGATCACAAGATCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCT + 4+2$-23,.23/9+7912,>?A=+&38=0C=DE@@1C8FDC4=6>92@?CD5AEFD;=3=?6$@@B>D@CGE?B9E9ACDAAE?2C@E5A8A:E?6?<+$>126*<:BD@F?@@CD@@=>?FAED-=<@>:::92>:4:82*4>:?7>13<775;0<<:27;@A@?:65==:>C?@;>?BEE?A48;B>;6;@GCFEC>AB;D8BA:CCC,FE?C6EG;FFC88BE<>?><@@7ADBBG9E;ADDD17AGAFDED<@=B6BDB@;?FFC9@<:E?E?FDB=@BC:C8@?=C==>>?B:7:A@A8CBAB196;<>>7;:;9>96?935956:7-979>?<596<56:<9/7B2F@7=9:4?192@*@C893@7@,9;B3;B?DD<?A>8<>@DDA594?B?=>:?2:9>=+;8=='97682@C:A=9=8?$CBA@=@A;D?C8BBDDC>?==;;9@=;9>-<;B5<@AC@;>;@?42:A:67=:??=EA6;E:>5?B=>;?9?:?:BE-?<667=87?49A>947--01118;42/89488*702603(/73,;>>8493,3=B<=&;B@@;C68B=@=,>:5B@@@;&:??ED>97<7:>;<<=08@EC6>E?A>A>8>?924>?6?AA@DG?BFABC;;:7=87<50<(@<>:69<;4@=47=A>989>6F>?89A7@EAAABF@CCB:B87@(@C?;15<<;D;>CE@>AF;>=94@726:>;F?:6B7AB@=B6?D?FDE?:B?DD<=?EDGG4<:?F3E>A88=G:?=@=BC'BADDA>C<@5AA+;<4?,<>8@=B3?CA?6@5DCA0:<7=AAB7<7@?:;A>:>0;8A9>=/?0=6=?B?@9<;9;>?BC@62;5=;>;@;8<@>:=>>=5A7<.=<=.:@.>7>>@=:BA7<;B@:A9;;A9<<53<>6???24<:>8;;-??>>;/,4==8;4=9:6:8<=6=?378649<;;4:02=/4783;67>8;:;992>=:88<359::17<6=2;;>:173;89;;;;88>;9>66<7,=;>=<<089?:><>;6?::865<;5=5<::<;:3.=;78807:%639==:%=98;<.?56;':;;3=>>.=9897$45:17=65,8?:;=9;3<;79>=;7565726+;977:<78;%184919692>;;378653:6<;6:1;*6;:89669$9A?7AC8?=?3>A?90A4>A9B87>@<+.?@<77358;97*5<45/B>BAC<6@<=6?B6>@@>8982(8><@=B>4:5'7=*@4C=A?A?8&7B6<>>=<7'-5:=816:9772>;=8=799=8:=78;73+141=949>0>8>299<<6: @rCer/2324/1752_59_CCS ATGGGGAGCGCCATTTTGTGGCAGCGAGACCCACAAATAAAGGGGAGCGCTGGGTTGCGGCGGGACTAGGAGTGCGGCGGGCAGGCGCCAGAGCTGTCCGGCTGCGCGGGGGCCCGGAGGCCGGGCGGCAGGGCAAGCAGCGCGGCCTCGGCCTATGCGACTGGCGGCGCCGGCGCGGCTTCTGCCTGAAGAGGATTCAAGATGACCAACGAAGAACCTCTTCCCAAGAAGGTTCGACTGAGTGAAACAGACTTCAAGTTATGGCAAGAGATGAGTTAATTCTAAGATGGAAACAATATGAAGCATATGTACAAGCTTTGGAGGGCAAGTACACAGATCTTAACTCTAATGATGTAACTGGCCTAAGAGAGTCTGAAGAAAAACTAAAGCAACAACAGCAGGAGTCTGCACGCAGGGAAAACATCCTTGTAATGCGACTAGCAACCAAGGAACAAGAGATGCAAGAGTGTACTACTCAAATCCAGTACCTCAAGCAAGTCCAGCAGCCGAGCGTTGCCCAACTGAGATCAACAATGGTAGACCAGCGATCAACTTGTTTTTCCTAAAAATGAAAGGTGAACTGGAACAGACTAAAGACAAACTGGAACAAGCCCAAAATGAACTGAGTGCCTGGAAGTTTACGCCTGATAGGTAAACAAATCATACTCCCCAGTCAAGACTTCCCTGACAGTCCCACTACGAGAAAGCTGTGGTGGGACAGCCAAGTACTCGTTTCCACACCAAGACTCAGACTTTTTGAGCCAAAAAAAGCCACATTCTTACACTGTCCAGCTTGTAATGGTTAATGTAAAACTTACCAGATGAACCTTGTGTTTCAGCTTTTTTCTTTTCCCCTTCCCCTTGCTTCAGAGGCCTGATGGCGTCGGACTATTCCGAAGAAGTGGCCACCTCCGAAAAATTCCCTTTCTAGAACATGTAGACACTTGAGAAATGTTCTGTTTGAAGAAAATAGAGGGAGAAACAGAAGTCTTAAGTCTGTGGCACACTGTGTCTTCAGACAGTTTGAAGGAATGAAAACCTAGAGATTTTAAATCATGAATTGAAACATGTAAAATTCCAGTAAAATGTAAAAATGGAATATGCATCGCTCTTAACCTTGAGCATAGTGACTTAGAGACACTGTGTATCAGTTTTGCCAATAAGACTGTGGACTTCATGATTGTTGTTGAACTTCTGGGTCAAAACTCAAATGAGGTGAATTTTGCCTTTAAAGGGTTTATTTGCTGAGAACCAACTTTTAATAGTCACGAGAGAATCAAATAATAGATGTCCGTACAAGTAGCGCATATATTTAACCATTTAGTTTGGGGCTCTATATTACTTGCTTGAGCCTTAATCAATGTGGTTTTATTCAATGGTTTGTTCTTTGAATGGTTGCAAAACTGTAGATTATCTTACTGAGGACTGTACAAACGTGAAGGTGTGGTATCAAACTTCAGGTTGAAACTGTTTGAAGCATTATAAACATTCATTTCACAACTAGATTGTATAAGGATATTAAGCTGTGATGAGACTCACTGCATTATTTTTTTAGTGAATTTTATGAAATCCCCATTCCATTCAACAGGCACATGTTTAAAAGAGCATTGTCGTTGGTGTTAATGGGGGAATGTGTTCCTTCATTGTATTTGGGCCTTTTGTATTGCACTCTTGATATTAAATTAAATGTGCC + <:/15'688<=59<>;)9?;(BA@>;5.?3D?DB829?$>A@8?CA>>>CCAAB?>*B(CEED<=<20?-9E0A;<3&:-7=7=@==B?C@??@C85045AB<=/7C6;8>>3?=GC??<8CDCAF@>>B(:;;?:A9DC=CABC=5@/B0?@@98>:6>:4><>>8@:.55<:A7=:<;9@@>4;98@BC=:B?&<>79:?:AA??>;<77A3CED?E>C>2149;B@<;BB>9ECFC,@=F;;
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rCer/2335/2468_82_CCS GGACTGGCAGCGGTTGGGGGGCTCCCATCCCAACAAGGGCGAGGGGCTCTGCAGTCGCTCACTGCTACTCCTATCTAAAATCCTCCACAGGCCACCAGTTGTGGGCGTTGGTCCAGAAGACTCACCGCCCTCCCAGAGAGTCTTATCAAAGGGCGAGAGAGGTGCAGGCGTGGTTTGCTTTATTCACCCTTTCCTCTGGACCATCGGCCAGTAAGTACTGAAGGATGGACCCCTTGAGGGACACGCTGCGGCGGCTGCGGGAGGCCTCCACATTGGGCGCGCACCCCGGTCGGCTGAGTTCCGGGTCGCAGCTCCGAGGGCCTGGGCCGCTTCCTGCACGAAAAACAAGAGCATTTCTGCATGACTCGCTGGGCCCAGGACCTGTCAAAGTCGGCCTTCGGTCGGAGCTGTCCGAGGTTGCATTCGCAGGGCGAGATCACCCTCTGGCCCTGAGGAACCTCCGGGCCTGGATGAAGGACGAGCATGTGCCAAGAACTCTGGCCACACAGCTGGACTCGCCTTCTATCGGAGGAGCCTTTGGCTGGCCTCATCATTGCGCCCTGGAACTTATCCCTTGACCTGATCGTGGTGCCCTCGTTGGGTGCCTCGCTGCAGGAGAACTGCGTTGGTGCTTGAAGCCATCAGAATTAGCAGAGCATGGAGAAGGTTCCTGGCCGAAGGTTGCTTGCCCGATACCTGGCGAGAGCTCTTTGCCGTGGTGCTGGGGGGCCCCAGAGACGGGGCAGTGTGGGACAGGTTCGACTACATCTTCTTCACAGGGATGCCTCGTTGGCAAGATTGTCATGACTGTCTGCGCCAAGCACCTTGACACCTGTACCCTTGGAGCTGGGGGGCAAGAACCCCTTGTACGTGGATCGACACTGCGACCCCCAGAACGTGGCAACCGCGTGGCCTGGTTCGTTACTCAACGCCGGCCGACCTGCGTGGCCCCCGACTACGTCCTGTGCAGCCCGAGATGCAGGAGGAGGCTACTGCCCGCCCTTGCAGAGCCCTCACCCGTTTCTATGGCGACGCCCCAGAGTCCCCAAACCTGGGCCGCATCTATCAACCAGATAACAGTTCCAGCGCTGGCGGGCACTGCTGGGCTGTGGCCACGTGGCATTGGGCCGGAGTGTCGAGAGCGTCGCTTACATCGCTCCCACAGTGCTGGTGGTACGTGAGGGAGATCCGCATGCGGTGTATGCTAGGAGGAGATCTTTCGGCCATCCTGCCATCTGTGAACGTGCGGAGTGTCACGAGGCCAATCGCAGTTCATCAACATGCGGGAGAAGCCCTGGCCTGTTACGCCTTCATCCTAACAGCAGCAGGTGGGTCAAGCGGGTGTGACCCAGACAGCAGCCGGGGGCATTCTGTTGGGAACGAACGGTTTATGCACATGACCCTGCCGCCTGCCTTTTTTGGAGGGTGGGTTGCCAGACGGGTTGGGCCAAGTACCCACGGCAAGTTTCTCCTTCGAACAAACTTCTCCCACCATCCCGCGCCCTGCCTCCCCTGCGCTGACCCGGGTGATGGAGAGGGCTGAAAACCGGGGGGGGGGGGCCCCTCCCGGTGCTTTTTAACCCGCCCGGCATTCGCCGCGCCGCCTGAGGGTGCTGCTGGTGGCCATGGCAGGCCCGAGGCTGCAGCTTGCACCACTGCTATGAGCCCTTCCCCAGGCCAGGCCCGAGAACCACCAATTGACGGCTGTCGCCTGCAGCTGGTGCTGAGACGGGCCCGGGCTCCAGGGCCCGAGGAGGAAAAGGACTTGCAAGGCTCCAGGCATCCTCAAACGCAGCCGCGCCTCTCCCTCCTGGTGTCTTCCCTCTCCCTGCCTCAGCTCTCCTCCTAGCCACTCCCAACTACGAGAGCAGGCAGGAGAGCAATTGCGGAAACAGTGCAGTGACCTGCCCCCACACCAACCACCCATGTATCAGCAGAACGAGGACGACATGGCGCCTCTAAGGCCACCCGTCTCCTGTGGAGCGGGTGGCCGCAGGGGCCCTTGGCATCTGACTCAGGCCACACCTATGAAATCACTTGCATCCTAAGGCCATCCCTGCCTCTAGAGATCTGTTTCCCCATGTTGTCTCAGTTTGGGAGAGACATTAACCAAGTCCCACTTTTGAAACAGTATTGATGATTCTGAACCGGCCAATTTCCTAAGAAAGCCGGCATGCTTGAGAAACTACACTTGGACAATGACAGCAGCTCCTTACAAGCCTGCGGGCCACCATCCTCTTCCTTGGCTCCTGCTTTTCCTATTTCAGACGATATCAATCCATACACACATTTAGTCAGGGAGGGGGGACAGGATGCAGACCTGAGTTCTCGTCTCCTTAGTCTCTCTGGCTGATGTCACCTGAATAAAGGCGTTCTTCCCTGGCAT + $'*-//,)//-/,#(*$%&((.-'&,*.-(+-*.-..**#,.-**),../-&/-(+#-.+*-/....("*&'-/+/.*--.,-.*'././*,-.,.///&.'(%)-"&"&&'--//,*,.,/----.*,%.,+,/..-/.+&/&.%.,*-$'&,.-,#*.-*.,...),.-/+.)+-*,"$#""%+*'',#'))%*$.'..-/,-.'&--.$&-..$//,/-.+///)/-)(#&#*.-+'/.////////,./)/'..),%.-&*&&*,(./.$/,*.../-.*$'$-(-./'/////.$),.*$#+,'-)---.)(-*$*&..,),...,*)*/++--.-)(''/)).,..*.'#(#.*,.-)&$'.*,-+#&$(-/(+-+/.#+,+**/-.+,#/)..+.,/&./..//,....+(-.&-.$/.-..,*.-,-'/,++&%#)&,($)(-)&',++)*-)&,(#',,-&*')'+/),,/..)//.//&,)%..'*#--/')+*-)+/'+.-&,-.).+*/*,"(/+))).),.*)/*,+',..+&(-.)/+('-/,/%),*/*.%(/*-/-'&%&.)&,./(&-(&.*-*)*(.-.#+-,)./+-.,/-//+&/**.'(,./(/.#/,/...$/-,/'+,('*#()/(,/*,-/.-)./*--.&.$.$*-).+*-/-,.'-#.',)-'*,//.),...(&.--/..../),/,(/-/,..).)*&&('(*(*-'+),-'$(##$..-.-&$,--#,/),-(-&,,+.-/*+.*+,-&-&(/".))))//(.)'+(-.,*/.-.//*/-/#'./-/+++%/'.(..$/.-//.//''-+,,#.+/..&,&&')).)+..,-)',.&/../.&),////.-..//./%)&(*,*/.'./..+.,,.-../**+,../+/*-/",,..-.*&-#-*+,-,,.,/),/.%-'+&)(.&,,-"/.),&-%-%+()''.&.,&/-,/)-.$+)+-.(./+((,/),&#'/+,.).&*'.+,++(/.),&%*)*&)+,-.'*&),*+).(+)+))*,'-'-((,.&(+-",/+-,*&./-#))(,//&-,+/-*%..)+.,))+*+/(./,),.//-+*-.+...)&*,&*##'&$&)+-,"*.(++../.,/*'&*)-/*/+&+$&($+-..&-'-..,"+&/.')*%&)-'"'+.))#((-*&-$(**)(+.)..*)...#%%($,%)*'-+(-))%&'&"..-.,///.(-#*,.).(/.///*,-,,/(*$-'%-''.--,/.)(,+(#--),-(-,./((,./.%'*/*/+),#-*(.(--$/,,'(+&'--(')-*#-+%%%-,(*+*&*(.-,.''+-$#,&$((,*&).(,,#.*#+)(.#$-.&-%"+-(+('./.*,*)''&%()&*.%.*(*)$#-(-'%'#&&#)#.%**,%'-&%#*&,'*('*..)&()($/*))'/-'($.,-.**/'&,&%'.+'(.+''***--)%&-..&)+.)&+-$"##(,'.%#(()#"-*('-*-**++'$"#&++$&'*,%,(#$+%(%$$$$$(&*&'*,.+",,,#$%"*()'+.*-'-*.,.%-.,....&&.'-%-,&#(,'.*'../,./+#.///+%'/)$&+.(,%///////+&.-.--,//&-..//..+,&*'')(*-.(+).)*#%#....,.-/',+,&$.-.(&/..../&$.(-...(,)-."!-'-+..%+(('.+((.,-#.&(+(,-.-*-.*.'(..*.#,**.,-/'..(-./*.//-./.-*-"/../,&/..'+&&+)))-$++-%$--..%-++.-(+)%'-*(.'-'&',.*,#&)")/),*-/,,+--)(&-.'*.('&#%#*&''&#++)$#$-$-'&$-.)+./-&//.,..+/),'$*+-).-,).-..+%.&-))-,,&#.,),%*/&,..,//').+..',)&+-,,%+..&-+&(--).&.,.)+$..'(..++./#/.%,()++,"+&,/(//..-.-.)$(+),(###.',#-,&/./.$../..,#,./*+&//-(,&(,&.*.".--".-%&.(+&*)&.//,*/."-./..#&+*%&..-.$//*/(,%*,.)-,*,-,#%,&&)....)#)&*-.'&)$.../%.&',((-,(+(,-././)&./,./%$#'/./)+/-.(&((.,)".')'.)(%/-,-..''.,'++."--'$/,/././',+...-"/--...*--.)(-**$+-..-#+&-+'%(*,.),/,..%'-.--&.-"...%$...&$%../)/.*(.,)&%#&+(..+/*.$"--.(.././)"+..'.'+,-%#././-//..+++//&..,.(.*&.*..+&*$.).$&.$'&)..+.." @rCer/2336/25_1589_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAACAGGGTTT + KK8KKKBK3JIGKKIKKKKKKKKKJKFKKKKKKKKKHKKKKKJKKKKAKKKKKKKKKBKKFKKJKJKKKKKKJH;KKKGBDHIKEKKJIKDKK@KKJHKIKKJKJKKJKKKJKKKKIKJKGKKFJI/KIGKKKFKKKKIKKHKKKKKKKKJJKKJIJKIKIKKKKJ=KKK8KGKKKKKGKKKHDKKKKKKKKKHKEKKIKGKKKIIKKIKJKJKKF6KKJKKFKGIKKKKKFKIJJFFKKKJKKKKKKKKKJKJIKKKKKKKKK3KKKIKHKEJJKH?KBKKKK@KKKKKJKJJKKKKKJKKKKKKKKKK>KKKEKKKKKKKKFKKKKKKKKGKKKKKKDKKJK'KKKKEKJKKKKCKKKKJKKJKKKJKBKKJKKKKKKKKKFKJKKKKKKKKJKKKKKKKKKKKJKKHKKKKKKKGKKKKKKKKKKKKKGKIKJKKKKKKKKJKKK=KJ4KKJKKKKKKKKKKKIKJKKEKKKBKKJKKKHKKKKHKKKKKKKKAKKKKJKKKKKKKGKKKKKKKKKJKKKKKKKKKKJKKKDKKKKKKKKKKKKKJKKKKKKIIKKKK&IIKKKKHHKK7GKK*KKGKKKKKKBKKKK3KKKKKK5KKIKKKCKKKKK0IKKKF-KIIFKK(KHKK=KKIKK)KKKKKKKKJKK+KKKKFKKKFKGKKKKKKKKKKKKJKGKHK5KKKKKKKJKKKKJKBCKKKKKKJKKKJKKJ3KKKKKKKKKKKKKKKKJKKKKKK&KKKGKKKKK$IKJKK&%6KKKKKJKJBKKCK2KKK7KKKKKKJKK&KK?KKKJKKKAKKKKJKKKKKKKKGJKKI-KKFKKKKKKKFKKK2KKKKKIKKAKKKKKKJKKJKKKKKKKJKKAKDKKKK0KKK*KKKKKKKKKJKJKKKKKKKKKKEKFKKKKKKKKKGK@KJKKKKKJKKKKKKKKIKKIKJKKKKKKKJKKKKGKKK9KKK,KKKDKKKKIKKJKGKKIKKKKKKK2KKDJKKKKKKKKKKKKKKEKKGKKKJGKKKKKKKHHKKJKKKKKKFJKKKKJJKKKJK@KIKKJIFHFK3KKKJKKKKKKKK,KKIEKKK:KKKHK(KKDKF@K5KKIKKKKKKKBKKKKIKKKIIJJKKK7KKKKFKKKKKEKKKKDJKKJKKKKJKKKKKKJGKKKKJKBKCKKKKAKK2KKKK7KKKKKKKKKJKKKIKHJKKKK)KKKJKH?GJHKJJKK5KJJKKKJ1KKKKIKHJGEKJKKKK*KJKKGJKJKK8>8;:;04;;:<<>4>94619-8(56,/-03412<89:2.853&8756=8::;+5,.33;999956,(8255:4;5(*4456/937:;78339?:988906:;5;6=<7899?>72>7557=087.;:696;9:*41.<;;6199;:->723853641,033<8738:890,7<===56676<<;32(07:;/86/:<829::=;=::>;6:=>>7;:;482;1%85597:9<;>7;<87.:765364;9;89848/;;==:6/.;55-6<448:<=>37%98<7><58<797:9::5+079132<7<8?;<;::==<;7>0;:=<29375<;87868.;5.#888:;=8;<.3:259955<9;4978=<;85;784:19716;4(33936.;85;89.9.8<9775?;;45589998,9.3,&/8298479(81;2:48<;@@;:=>@>08:14?39<>9?>+3*72+480:329=A:?8>A>==@0?48>;::<>AB=5=8A;=?C<7=?>=5789?0<4>C>?:?:=9@;@>@?B=0<7@;:=??5)9:@B3@A>?A8?@A;@>@?5;A>=>1<33'7:/89A>5;=>04/:5<<0=35=;>7?781;88?CC>+;A;7@B?>34BB@=C8AA=<:75:>>7=>>9:6>A?6:7>8A:?:59==@CB=A=A=694<<>9C>D3D=@5B=+4;/>852;@?E4?6<;==>EBEC;C8CD?@<:4<09D@E?@AE?;B:A><@E::E?B:B;??;FB?C:ECD>6>@?;@GG=EEA?;B>E;;52@>E>2DD0=EC??;AAECCC:@BC@B=D8=5DBACEDC<:BCD?;EE;F?7D94;;@E9DCDB24??D9?CC5B9?%B>>>531BBFGFD?DF7BE?=>E;9@/A;;;C=9+;EA?4??BA:@C;>B=>D:C?EDD3:21B?=@>EB=@7>=CC:BB?BFBGDF?=5A78>1>=A==?EB@;AC@DDCF:<DE@:A?8@?>C?F@FEC>;BF:GF8BCDBA>A=@7CCB>C@;;@:EFBBC=CGB>5<@>BCAB@GCEGA=.>ACBB/B1CED9??3>:@ECA@(@CC?BEE&7;%6>AD:A>EC;D>G?EA<8EDD?AAB2DDG;@.@?C?F?,DFE@9AB==@@DAFD?=@F;;<@=)9%C@C>CEEA6-;A=6=<4@E>G@/>A@;>:2AA?C(<;>>F;<9?>5A6=3=+@;?<>6>GADC%?>A=<5+AC5EGC5?B;><@>5@/DA<%BB><>6;93ECB7?BBB;F?D4A>@CGDGEBCEA8A;DFC6A?1 @rCer/2349/1605_58_CCS ATGGGGATTCTGGCGCGGAGCGGAGCGGCGGCGGGTGCGGCTAGCGGGTCGGCCGCGGAGCGGAGGTGCAGCTCGGCTTCCCCCGGCACCCCTCCCCCTCGGGCGCCAGCCCCACCCCTCCGCCGGCCGGGCCAACCCCGCCGTACTATCCCCTGCGGCGCGAGCCCGGGGCGGCTCCGAGCGCCCCCCAGCAGACCCCCATCATGGGCAGCCAGAGCTCCAAGGCTCCCCGGGGCGACGTGACCGCCGAGGAGGCAGCAGGCGCTTCCCCCGCGAAGGCCAACGGCCAGGAGAATGGCCACGTGAAAAGCAATGGAGACTTATCCCCCAAGGGTGAAGGGGAGTCGCCCCCCGTGAACGGAACAGATGAGGCAGCCGGGGCCACTGGCGATGCCATCGAAGCCAGCACCCCCTAGCCAGGGTGCTGAGGCCAAGGGGGGAGGTCCCCCCCAAGGAGACCCCCAAGAAGAAGAAGAAATTCTCTTTCAAGAAGCCTTTCAAATTGAGCGGCCTGTCCTTCAAGAGAAATCGGAAGGAGGGTGGGGGTGATTCTTCTGCCTCCTCACCCACAGAGGAAGAGCAGGAGCAGGGGGAGATCGGTGCCTGCAGCGACGAGGGCACTGCCCAGGAAGGGAAGGCCGCAGCCACCCCTGAGAGCCAGGAACCCCAGGCCAAGGGGGCAGAGGCTAGTGCGGCCTCAGAAGAAGAGGCAGGGCCCCAGGCTACAGAGCCATCCACTCCCTCGGGGCCGGAGAGTGGCCCTACACCAGCCAGCGCTGAGCAGAATGAGTAGCTAGGTGGGGGCAGGTGGGTGATCTCTAAGCTGCAAAAACTGTGCTGTCCTTGTGAGGTCACTGCCTGGACCTGGTGCCCTGGCTGCCTTCCTGTGCCCAGAAAGGAAGGGGCTATTGCCTCCTCCCAGCCACGTTCCCTTTCCTCCTCTCCCTCCTGTGGATTCTCCCATCAGCCATCTGGTTCTAAGGCCAGTTGAAGATGGTCCCTTACAGCTTCCCAAGTTAGGTTAGTGATGTGAAATGCTCCTGTCCCTAGCCCTACCTCCTTCCCTGTCCCCACCCCTGCATAAGGCAGTTGTTGGTTTTCTTCCCCAATTCTTTTCCAAGTAGGTTTTGTTTATCCTACTGCCCAAATCCCTGAGCCAGAAGTGGGGTGCTTATACTCCCAAACCTTGAGTGTCCAGCCTTCCCCCTGTTGTTTTTAGTCTCTTGTGCTGTGCCTAGTGGCACCTGGGCTGGGGAGGACACTGCCCCGTCTAGGTTTTTATAAATGTCTTACTCAAGTTCAAACCTCCAGCTTGTGAATCAACTGTGTCTCTTTTTTGACTTGGTAAGCAAGTATTAGGCTTTGGGGTGGGGGAGGTCTGTAATGTGAAACAACTTCTTGTTGTCTTTTTTTCTCCCATTGTTGTAAATAACTTTTAATGGCCAAACCCCAGATTTGTACTTTTTTTTTTTTTTTCTAACTGCTAAAACCATTCTCTTCCACCTGGTTTTACTGTAACATTTGGAAAAGGAATAAATGTCGTCCCT + 768>8350)-3169,1;5:667//<37-431765008143-09625&2(5;02.1<;;8399(613?3;<=56@C4:;:=5:8+::=)5024'1?<8:96:?;06>5;=9@5A9<:?022-2;<.<555:;BB>@?;:48>>=421:46;601:<58=84<9>3B;7A>=<=@4.0;A;:8=7:<165357;97@A@<8?:=3;9>4<;476<9597AB:9<=9;97:2B:=422<:>/;A8=3::8<82A@863?C<7808029=99=;A968=968;;1=;?8?.78>:>9373:<<;'1+924.7A?<=88457=9:6448%2?A>54=8>1<7578<9<4<>A:-$==5<@A@BB;>+A@?@65AB69:BA@597A9;666496%3:>@<(83=B@AA==A.;;8;A=1????'@C?@?=BCB?><><>4@=B<2>4/9<<@8=7A39:-9:<6A=C:9:/)432.2.:8<8A6?>?;29<43$86==<<><<7247:;;<>7534969:788)737>2;6:8?.669@B3'5;>78@6<=<:33:2@<5;=<54>(=9=4;:6<;;>>77=9@3C>;AA=2=/9???>;7618251;1>9=8;8@;+;AB;=4=;0@??4=;<3974/;.076463*2/8152B@A3973;88=6=:49;<3>2B=37;44+:;:.8::55-<78=@93.<5*,87294%?64/126+76AA@5.549A>@7>>CA8:8>;9@C6@/DF89?;:D083=;+;9.7:6C?C9<6:>:@CB.;:5<5=:@;C?C9?776.=;22;64::+<:=37=;;=CA6@A1>8<*;7<==A=47;4;5=@7<=?3:>>;248:.;6<*>8>2??>82&:A;.449;9;<=?763.*184:847:98/>43=:<:=9>.13=?>:;7=<<9;:;86163>==33;:4.87=7=43448:456:;461=9;=6A<>7A;>;37:261==:*;@/9=>3A7>3A7?<3=9@;A=>97C?B1A5@?B:2:9>B>299?99B>@>>>AA@67>AA8@=/?78;?4:;9<<*;B4B=;<<@?>>69AA>AC;>5:9+598B3:;9??><605=7:<7==8/<3<89:0;:16>:A9??=;=/7?@<87=+;AA?7:9;;49=>5A7>=7??=$3>?A?>::C<@><49;5AAA??=??8=>=9=2,'0>0>?3:5/88;@:6<08=?=0<4<:-=;>>3BB@6<:?@:58<<9>;<6<>9?;69=;:&-=@7>6@>?4>7;?>;><5562,?6B?>=>6=84337'525538-6>:76/=82;9336.:>>;466 @rCer/2350/37_4015_CCS ATGGGGACCTCGCTAGCGTTCCGCCTGTCCTCCCAACGCCCCGGACTGACGCCCCGGCCGCTAGCGTCAGCGCTCAAGCCATGAATTAAGGAGTTCACTGGAGGTAAAATGGAGGCCTCAGTAATAATTATTCCTCATCTTATTGAAAAATACTGGCCTTTACAATTCCACACCCTTTACAACAGAGGAACAAGGATAGACCGGAGATGGCCTTTCTTATTTTGACATTTCCATTATGAAATAAACAGAACTATAATATGGATAGCCCAAGTCTGTGTTAGTGTCACCTTAGAATACCTACTCAGCATTCCAAGTGAGAAGTGTAACTAGGCTTCTAATGAAGGATTATCTCAGATGAATTGTGGATGGAGAGACAAATCACAGTGAATGTGGAATGAAATACAGTAAAGTCAACACGTAATCTACAACTGAATGTTGTTCCCAGCTAGTAAGGTGTCCTTTGTTTGTGATGGTAAGAGCAAGATGAAATTACTGGAAATAAGCAAAGTAAAAACATTTTTTGTTTTTGGAAAAGAAAAACGGATAGATATGGCTATTTAGAGGTTATCCTTTAAGTGTCTGCCTCAATTAACTCTGACAATCGTTTATACTGACAACCAAATTGCCATTAAACAGAAGATTTTGGTGGAGTCTCAACCTAACGATCCAAATGGACTGGTTAAAAAATAAGAGGACTGGTCTTTTGAGAAGTTTCAAACCAGGATACACTATTTTAATAGATTCGAACTTGCTTTTGATTAACAATGGAAGTGATAGAGTGAAATCAGCAAGAGAAAAGAAAGGTCCTTGGATTTAAAACCTTTCTTCATCGGTTGATTCCTGAGTACGGTTTTTCAAACAGCGGCATGAATTAATTATCCGAATAAGCAGCGTCGATTTCAATGGCTCAGACAGGAGGGGTTTCATGATCTCCACAAATGGATGATGAATCTTGCTCGCCACAAGACCAACAGTTTATGAAATTATTAATTCACACTCCGAGAGCAATATACCCGCTACCACAGGAATTGATAAAGCAAAAAACTAGCAACGTCGCATCCCAACAAGTTAGAAGAGATTCAAACAGAAAAGGTGATCAGGTTGTGAACTTAGGCTAGAAGTGCTGGACCAGACCCAACTACAGATGGACCAGTTGGGGCATTGGAAGATCTCATTAGGGCCACTCCCAGTCCCTTACAGAGCAGAACCAATGAATGAGATATGAGAAGCCAGCAACAGTGAATGAGAAGTATTGGCAGTGTATTGTGAGGAACTTAATCAAGCAAAATGCAGCAACCTTGATGCTCGCTTGATGAGGAAGATCTTGTGGAACTAAAGTCATGCAGCATGTACAATTTCTAGTGGATGTCTTGTTATCGACAGGACACCAGATCAGAATCTGGACTATATAGGCAAATCACCGTTTACAAGCACATCTTGAGAAATTTCATGGTGTTCAGCCAACAATGATTTTGTCTCACATGCAAGGTTGAGATTAAACCTGGCCTTTATTAGTGGATGATTGCGTGGTCTTGAGATGTAAGCAATACCCTGATGGAGCACTAAACGATTCGCAAACTTTAAACAACTGATTGCAAGAGGAAGCTGTTAAACGTTGTTGATGGGTGGTGATATGCAGGTTTCGCTGAAAAAGCTGTCAAAAGGTCTCCCTGGATCAGATCTCCAATCAAAGGCATACCTGGCCTAATGAAAGATAGTAAACCATGAAAAAAAAAGAAATGTGAAAGACCACATAACCAAGGAGTGAATCGGACAGATATGCCCCTTAGAAACAAACGAGAATTCTGAAGCACATGGTAGATGTGCGAGGTTAATAACGATGCTTCAAGAAATGGTGCAGTTCACCCATGTTTTAACATGTGAGAAGCGCTGCTCAGGCAGTAGAATGGTAAGTGAATTCTTCTGGCATGCCTCTGCTTCTAAAGAATCACATCAGATTGCGGCGATGACTTAACAGACCATCAGAAACGAAAGTTTTGCTGAGAAAGCATAAGAACAATACTATAGTTGATGTTGCACAGAGCACTTATGAACTCATAGAGCAGACGTTTGCTTACAGGCACAGATGGTGCCACTGCCAGTCTTTTCTGCGTTGCACTTCATACGGTCAACTGGGGATACGCTTCCTCGATTAAGAACAGAAGTATGAGAAAACAATTTTACAAATAGCATCTGAAGCAGAGAGATGACATAGGTTGGAAATGGCTAATTGCCATTTCACAACAATCAACATGGCTGGAAAAGATTTTGACAGGAACTAAGTCCCAGAAAGCCTCCCTGAAGCCCTATTAATGGATGAGGAGCAATTTTGATGAAATTGAGCGTTGGGCACACAAACTCACTTTTCGGAATAGATTATACTGTTCCTCGTAGTCATTATCCATGAAGCGAACACGAGAAAAACTATTTTCGGAGAAGTCAGCAAGTGACATGGCTTCTACACTGCGAACAACCAATCAAGAAAAACAACAGCGAGAAACTCAGTCATTAATCTAAAGGCACGTCGGCAGCTGCAGACATCCTGAAGACTGGTGACCCACAGAGACCTAATAGCTACCAGCTACCTAAAGATTTGGCAGTTCAATAATCCCCCGCATAAAAAAATAAGTTGTCCCACATAACCTACCACCCATTAAGCCACTAACTAAGGCGAATAGAAACATTTCATTCACCAGTACCAAAATCAAAGTCTCCATTTCTTTTTTCATGACAAATAACGAAAATATCATCTTCTCCTTCTCATATGTTTAACTGATCACTTATTGCCACTAATATAAACCGGCAATAAGTCAAGCCAATGGAAACTTATTAATTCATTTAACTCTAAACATGGCTCGAGGAATTTTGTGTTTTTAGACAACTCATTTTCAAGTTTATACAATCTTAAGAAAGAAAGGAACTACTATAACCAAATTGCAACTGAAAACTGGCTTTAAAAACTGGGACCTTTACACCGGATTCTGAGCCTAGATCAGTTTTTGTAGAATAAGGAAGGGCAACTGATGAATGGCAAGGTCTTTCGCAAAGGAGATAGCAAAAGAGTAGGAATTTTACTCTAGATTATAAATATTAAAAAAGAATTTAAAAAGGTTGCTCCTGTGACCCACAGGTGACCTTACAATGTCAACGAGTATATATTATGCAAGTAGTGTAAACTCAATATATAGTAAAAATACGTCGGTTCCTACACATATATCTAAAGCGTTGTAATTAACATTCTTTCAGAATTGAATGGTAAAAAATTGTTTATTTTGAAATGTATCCAATAAGATGCGAAGAAATAAGACATTCTCCAAGATTCTTGGTTGATAATAATCATTAAATACTAGTAAGAAGAACCTTTTCCTAATTGTTATGATAACTTTAAAAGTTGTTTGTGTACATATAAGACTTCTCTTTTAAACAATCTTATTTAATTTCAATAGTTACATCCTAATTTTCCTAAACATGAGTGCCTTATTTAAAAGGGCATATCTTAAGGACTGTGAAGATGTTTAAATATTTGCTTTTTTCATGAGTGGTTGCATGATGTTCTTAGACAGGAACATTACATATGTAAGCATGTAATAATTATACATAAATAAGCCTGTCTTACTCATGAAAAATTATTGCTGACAATTTAGATTCTTTAAGAATTATTAATAAATGGAATACTATTATCTAATTATTCTCTTCTTCAACTTGAAAACATATTCTCAAAATTATAATAACTACCCTGAAGATACTTGTACTTTAGGGGAGGAAGGGCATGAGGAAGAAGGCATACACAAATTACTTCAAGTGTAATCCTTTATATCAGAAGTAATCTTTCATGCGATAAAATAGCAATGTTAAATAAAATTTATAGTTTCTCAATAGTCATAAAGCAAAATAAATTCTTAAGTACTGTTCCCCCCCCCATTACAAAACCAGAAACTGTATACTCCTTTAGAAAATATAAATTTACATCATGAAATG 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&+)('+.&-(/./*..*.-,++&*/./.(..&,/(-.-).$'--//'/&/.*#+'),*../+.&--/../-*.%.$-%',%#%&(,)%.-(&&,/.(,&',(&+-$%%(/,,*-),#(-./%#//+)-*-#"&$"*&)##$*#$&*$#$%&&))%&%,*%"%$#"#"$%&&""%()&'#%##$#',**+&&&*+-.%&'&$()'$)%)'&')""((#$),&'(*(+(%#"*(-,.-.$#'#'$%%+(&&-/$.%+////&./.((#$&'/.//")//&&+//./+/-#&,',)"/.*.....(--(..%,&)-/$/./+,-.((')%('-+-#$*'$-#/%.,--$)-#+"*%.+/-$/(../*-'.,,"&$#'",)./////-/)%'.---&$#(.)))$+-.//()#./'+"'&.//&&.-&$'+%##-+(.&--/-')$/./&+#/&*#..../-#$)(-'*.-/,#/.//-.#,./-"///-*-#./".)(-$&+(##&*,).//&),)...**&,+.*.*,.(,.(*)..+,')/$.-/..//)$.'+-%#&-&$).,-%./.""&%.%,&.,(.%-)-#-,(.%+/$-#.-.-$.#'--*..+%#-+."%#%."#-#&*+%,&+$,'"--).%/.($--*/.--.-,/.#/+.'*""$'-"-,)/'.-,//..+---#'#,+*,.-.('&,-..$.*)&+.)+./,'//,)*+#,.$*.--/##-&)&$$"&''-(."*+&.)-*/-%(,//./+&.*-/-.*-&../'%%)-",-*/./'.&*//-.--)//-+/../)-.&+-/.'/-*-#+"-+-#,/./+/--,(*//#+//-./"./.+/(-'.&#)/..)#,#&-(-(.('-$-.('"-.*'/+/-././*.--()+-#*//.#.//--(/".,.+**.(*/-//.&,.-,"#.('/*,-.//.$/*&"-(-//-..+*./,#/++-#/../('((+/,*/./+..+/-,%($$"#).$-.)..*-'./&('.(,,)&'%&#,'),%./$.%#*+*)$%$(.%.-./*.-.$.-/)'#$+)"*'".(../*..-./-//$(/-/.,*&%..-///..----.//)//%-%+%$$),$'&$*+-+*+$(&$%$#('#+(*'-.-#++$,)&$%#$%*',)(((**#-*(+--.,/.,,()*--/&+-,.'&).&*...'#./--)+%")$-.$+#(---.()+-#",(*,**/$-+/-.)*%..(##&-,.--'*+././/.$.)/-+,)$.&,&)../'#-($&)'/./...+#)',-''/-./#/.($.//..)$)"../.--..,-(...('/..///'//--.)$$&+(.$%)"-../&-+//.#'..-.+.-&++&*&"$'&+'+"*"+,#%'.,-&-)+)',.-,(-+)-+.*#(+**-.-)..''#&,-*,-&,*'.-)&**-+...,*-#-+.#'-&($..-*)',)-.*/+-)./*#*-*,,')($&'#"%*.(*,&-*..-..,.,,+'.'--(--,+&#'"&++,.//.)/-'-&"#&$%.*.-&,.,/'+.,$-'..*//(.#$$-$'*+(-'(...+'.+-$).,*.'*/-'/,(&,)'".(*/-.-.-#"+.%-#./*&/+.).-$'+)*(..+,+'-**#')&"$&-++/--(,#.--/%,,#.-./+.$-+*#%..*..-&'/.)'*(.$,(')%...)+..*$-%/--/,,*,++'*#,,).-.%-$#%--++--,*"##&''+',+,-"$&#$$$%)----.-(##'*--.+'---&)"*((#*$-&&)(*.%--..*-.,...,.$'+#'%'+&+($+(,..-,+-,*%-(%%,"%%*+,,*#&#$###($,&$(),#&---('$*'(..--,+-'*(*...&'.(-))(-&)-,((+&##(),$+)"-,)"#)'++*$%#(*%&*)$(*&*(',-..,--#+&$,,-..)'.#+'#*%#"%)%')($)---&(-)&$%$,)($*)(,,),,#(##+&',,#"##&%(''*#%+()$&)&+,(,,(*,.--.#--.#--**&+.,-,*&'&",-,),-*'+()-*-&-,,,)##&"-.*.....',(,".-.--(,.+.'-.#/"#+,($'"%,&&)(-+"..,,))--..-,%$&*&%*,-##--,(,(&,%&',&)&($,,-#'$++'-()-(,)(*%(#$'%+$*#'&,.+----&.,$+.&-&.,",--"'*.**--"()(%$./+*$./#,.-*)(#$&'-%*')*%.(+)(('$"(&,*%/..&-&*"%.&*-/-+/,#+,.%,.#-/%,.&--)*.,$$+'*(*(+#')%/-.'&.*..-,-+$,''%)##+.//./,&-#++%&&../&&,"'/-..%).."'.*.&'#./-/*&#//,#*$/((.%.-..'+'#+'($-%$,,++#'$.--&%(/*-*//.//,.+*-/,(-*&,.)/&(.***&.,#-'($&#&$*$(#,'.+"-(%*(.,.#'..#$+,).'.(%$%+)%#).'#&$-(%,,#"-.*../*'')%$".#/(./.**,.+/..///#/&*/.+/)/.-+-///.*-%*$"'&%'))*-//-//,#/*..)+-""$'&-%#""($%"$$,*$('""&'+&)#',".-)-,$#$-+.%'.+-*)#'$%,$('$*%(-,#$##%,.+**."&-+--#/.#-+/,,(/-+,$".-+.#(%*'--#(($%(--.%,,"&%"#%(#"!&(&-$-'&#',-.(&,.),+%)&,+'(,&+*"#'#(%+#"+**-),',-#(+&,+(,*.%#-%$().+(&&-&%,').$%$$#'%#+#&),*/--%##")+*"&#,$',,#&(&(,(*,##$$$%%(,&$$#+++("'-+."),'#*,'--($%$*'*#$%'#+$%#&'',($$%+$'')++++####*+$)''$''#$$"##$#&%($$$$'%'$%(',$')-,#$'/+#-,.()%')&/-.(*/.'-%..&)*#%#&+-,-#+,'#$#%&$"$*'.....*&*.,&#+#,%(+,,(*$'((%*+('')$(%++&(&',%-(+&(,'')%%),*)$&+#**$(%*###''##$$$&&+&###%%'$)-++,,*$*'#'$**$,+,.-'..."*'.,-#+.',,)--(,),&''*,,+,%%,&.--,+)#%$%%)--&++$*&)$*+&$$%$+'),,"+''+))##*)*,%-&%-%+'',&,'()-,(''.(.).),.()'.,/*+-./#%&&$,-%(+(/.)+-%..)#")+*#&/..*&,"((.#&#&/'$.'./$)+%$&'',*+)".$,'--.'(-&)$&)'*)&#)*%$-)$&$*##&'#(#%(%+&%&%%%(''+).)..$-'-,(.-.'..$-+('-%&'%,(,--(,---%'",,+"(%)*.(&-.##**/%(*-)')-,)..)()','-$,$///-///.*+/.-$.&$.)./,*/-//.&-.)*.-///(/+&&.--+//.$/++.#..-),-$./*&/..&-((-&,.//,(/"-*+'('.//,#//'/-./*.//#/..+#-...(....--#/*/#//////),#-&.-/.+%/-$(",#-"#/)*//+//%,//."-&/"//.//+,%&'%.-+&-#-///).,).,-.+,-.+/*/.)/.//--),/)(//,&*+./-*/.*"&..)+,/#,*...-/.-.,(/.)-%'$*+".*/-/.(.&''--..."".).-..*-'./+,,,-/..-./"/,),-,++,..-*.)-+/#/.--*$./',/(....-&.*,"-/..-./$--/-.*//$*.+.,///--/%//.*/.-**//#.,#,'&,(*,#.//(//.+.$&.*+'$-.$&#./.-*/./+%*//-./$/&&../,-)./((+&(../+.-.."##(*#$#'#$&$..-.&"**(&(/.,,$.///./(''-''$*.,.$'+#..",)*%+.+#)--%,-'(../ @rCer/2352/29_1680_CCS CTCTCAGAACCTTCCTGCCGCCGCGTTCGCACCTCGCTGCTCCAGCGTCTGGGCGCGTTCCAACCTTCCAGCCTGCGACCTGCAGAGAAAAAAATTACTTATTTTCTTGCCCCATACATACCTTGAGGCGAGCAAAAAAAATTAATTTTAACCATGAGGGAAATCGTGCACATCCAGGCCGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTCTGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGCGACCTGCAGCGGACCGCATCTCCGTGTACTACAATGAAGCCACAGGTGGCAAATATGTTCCTCGTGCCATCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCTTTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAACTGGGCCAAAGGCCACTACACAGAGGGGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTACGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCAGCTGACCCACTCACTGGGTGGAGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGGTACCTGATCGCATCATGAACACCTTCAGTGTGGTTCCTTCACCCAAAGTATCTGACACCGTGGTCGAGCCCTACAATGCCACCCTCTCGTCCATCAGTTGGTAGGAACACTGATGAGACTATTGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGTACTCTGAAGCTGACCACACCACCTACGGGGATCTGAAACCACCTCGTCTCAGCCACCATGAGCGGTGTCACCACCTGCCTCCGCTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAATTGGCAGTCAACATGGTCCCCTTCCCACGCCTCCATTTCTTTTATGCCTGGCTTTGCCCCTCTCACAGCCGTGGAAGCCAGCAATATCGAGCTCTTACAGTGCCAGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCCGCCACGGCCGATACTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAAAACAGCAGCTACTTTGTGGAATGGATCCCCAACAACGTCAAGACAGCTGTCTGTGAATCCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGCGAGGGCATGGACGAGATGGAGTTCACTGAGGCTGAGAGCAACATGAACGACCTCGTCTCTGAGTATCAGCAGTACCAGGATGCCACCGCAGAAGGAGGAGGATTTCGGTGAGGAGGCCGAAGAGGAGGCCTAAGGCAGAGCCCCCATCACCTCAGGCTTCTCAGTTCCCTTAGCCGTCTTACTCAACTGCCCCTTTCCTCTCCCTCAGAATTTGTTTGCTGCCTCTATCTTGTTTTTTGTTTTTTCTTCTCGGGGGGGGGGTCTAGAACAGTGCCTAGCACATAGTAGGCACTCATAATACTTGTTTGTTG 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&043608978;-8.55-&04.7*44+2201-+707:65:00475:3<:>/$;99:<<788:,607-:556:0?<59>959.436<85'==:74905>>>?<%5857&.=&<;:26;:05;8?8?9:4::;8:=*<8;;:::/9,:$1736>3=)'/-(89+>;;<;.5926954<91;596:;;9:8:19?957/60)3:8-827.7,30-453.699.5554/*0.33544*21&5.59-6651+010/28-212094349-1&44442565:4.94686/5%76-108/3,,'451/,0/1076424-62'/3545:33;5.941341.9.97.,.0.2%/%-696032.57/546'.3.86526++11255738,50885882+3,3'56348864778:29:04,/2204-.75071973'7237/821+.2%.0252'0687175'1%340:47539-10/4/05216/$84/,84/84/5:3:14.963640524:-*,42920929/45241580.85010166+0-22.30536.672.1&/11673)445553-626:9800'+476.34:+03.26363'533-135411(4%%)10-%31-2/5988+4*$.,$+03./&222-1(27596,2856921-3,5:36.4,8-..58%43,*3104:,2+&2647255578&631.5(/2,(3,%-2*4*'22-4/.1/.*2061($$427892845)/,/&.66::72%57,//68/54:&.-104662/4.1255346%''.614094196276:576-*')#-890306529:153*/16;..:64952.62&.,/03.22432181(/-2.3/294316,091((*%05%0805-1234*/25/03449.4;76*0115487::64-327428-'340+5)473.6-,/1-06:45&,.+-/3162&1356;9%873*'-+"$(/+4532:977-5128+6.45329.5-13;3364.348864:48596798:11,7/0/63/--20709,)197*.25385882:65256*64572491/0:'0645)$*./.84515:4060,3,*:6::97775//0305362-.09/482834:83469886013++:-54-.2266.78'443/-1144543*3*348824-84-:46+784%13,466384:718.87-2+/02884)4)66/39267//5*878#41-21:708:4,/81:8075(:6%79/693417'055'13+6+1563497-20*4/0324>5926/6949/5677#/;:17%,/.;6<183:4<5<23+/989<9;626323$21'-=:60/.28:58;246=>=999.3<;689:293;1<8,69/8<.:::>4695;95677=8:781487=/6*>+27137408(;90-<:020.4(,455,)-+%)+,%%573<:,7/41-*,+10+105;<:0=<:=9.*2778&2<7811791,).(-+8:9::<7?3440<:3817:9897=;=8$*&;547:5:4=8<1:% @rCer/2353/1200_66_CCS TCTGGTCTGTTCGTAGGATACCACACTGATGAATGTCTCAAGGAGAAATCGGGAAAGATTTGCACCAATGTGGGCGGTTGGAAGGCTGGGTATTTGCTCCCAATTCTGGTGAATAGAAGAAGGGCCTGGAGCTGCTTTGAAGGACTGCCTATTGGAAGCTGGCTACATCTGATAAGGTGGTCATTTGGCATGGATCGTACGCCTACCGATGTTTTCGGGTCTGGGATAGTATGATCATGGACTTCAGTCTCCCCGATGACCCAGCATGGTAACATCTCCCTGATCAGCTGGCTGACTCTGTACGTCCTTCATCAAGAGCTTACCAGTGGTGTCTTCGAAGTTCCCTTTGACCAGGTGCTCGGGGAGGCTTGGCAGAAGTTCCGGCCAGTGCAGGAATCCAGGTAGTTCGGGGATGTCTTCACAGTGGGGCCAACCCAAAAGGATTGCACAATGGCTGTGAACGGAAGTCCATGCAAACTGCTCTTGCTCAAAGTTCAACCAGAGTTGGCTCGTTGCCGAGTCGCTTTCAGGCGTGCATAGTTGAGCCTGGCCATATTGGTTGGGTGCGTCATGGTCATCGTTCTTGGAGGAGACTGAAGATACCTTTGTCGGGCTGTGCACTGGGCGTCAGACTGGGTGCCCCTTGTCCGATCTTGCAGCGCTTGGCCAGTTACAACCAGTCCTCAGGAATTGAAGAGGCGCTGGGCAGCTCAAGGCTTAGTCTTGCCGGCAGGGAACTTCAGAAACCCCTGGCCATAAGTAAGCATGTAGAGGGCAAGAGCAAAAGCCTTTTTTCGGTCACTCGTTGGCTAAACTAGACCCCTCCCTTGGTGTCAGCTCGGGCAGTTCAGAGGCCCCCGGACAACGATTGCAGGGTCGCCTGTAGTTTAGCGCCCCTCCACCCGCCGCCGTGGAGTCCGTGCCGACTTCCTTTAGAACTCTCAGAACCGAGCTCCCCCGGAGCTGTTTGGCGCTCTAGCTTTCTCGTCGTGTAATTGGGCCCAATACTGTTTTTTCTGCTTTACTTCCAGTGTGGGAGTTATGCTGAGCCTGGTGTATCTCCGGGGTGGCCAAGCAAGATTGCCTGCGTTGGATTTTGTTGCTTAAAATAAAAAGCCTCAGTGACCATGAGAT + ,&.'()-.+#'*)##)$"%',*+-.,..-)/,-/..+..+./(&--)(/-/,(-)./-/*,/.+.-%-,+..)$#$)()-#&+/+.$/-*.#-*(/..,-,-.#$,/.,#+-(/&.+,./+&+$&,./+..$//..#'.'+)%-.*/)/")/))+.+/$/+,*'".."+//*//./,).,'.(.'',+.-//(-/-./+./+.."-+..%-*$,,..'*..'.+',#,././/,//&//*,$/*/)/)..#)))/,//--,,+/.-#/(*#,../+.*,)////),///.'///-././/+.///-.,+.///,'*'"-.%+--'/./,/./-/*,/.+."+,+"*)+.+.-(/*(.#."-))()-&..)/+%+..).&*&'.'+,&,-.**-*)"+*)"/(-)(-$/.&$)./+.&+$,+../..))(*),-*,+$'))-%&.(.-".*,".)+*....""-%&+..,-#..--%)-+/+.($,.*.,%+$.#-.',-.,/'"/)/+)-%,,#.)-.(..$/-/)'/*/*&//)-+"-..).$-+-".($#$"""'-(+#,$)#+*,),##+""*$--..(',#.)"+(,,+-*.'())%"#'!#&,+#(*$+(-(,"&-(.)$$,..$.*./*,).*)#)*.).",%/)+*.$.",.-.+/).++$,./*&.,-+-&&.,+.,%/%((/).(,-+-+",--%*),*.-),+(.)--%"--$,*.+,.**$-*&*",)(++-'#(*&()'.)(+)'"+..&+/,$*.-#,"*&$-#+.#-,,'*&.)",###&+-/+./'.."..%.*-..*-#.--&))%,.**)-$+'....//.,..,)-(,.)"%)+-(('&'(*),.,&./.,)/.-/+(-,#*,...).,'()&-/*,**-*+%(+(&*+-)%.--)$-.+#...+.&&-.)&&+((,.-#*.#('"+$,$..*/./++'*+.*).%.//#*/,)/./,.+/*,),+&)).,/...$**#.+$))($*.(,..*'#)**,-+#('$+*-$(%#%-%),$'.+/"*//(//&.+$..'/..-.*.,"/*))./,#)*(-#''-"$'.)-*.",*#.)#.(*$.#$-+.+'**,/"+(&./*.++.///*,(.//./-& @rCer/2355/0_482_CCS GACATTGCCTCAGCTGCACATCCTGCCCTGGCTCGGCCACCCTGGCCGCCCTCGCTGCTGCCACTACCCAAGCCCAGCTACATTCCTCAGCTGCAAGCACTCGAGACCATCCTGGCCCTCCAGACCTGCCTGAGCCAGGAGCTGAGCACCTCCTGCGCTCACTCCAGCCCAACAGAAGGAAGGAGGGGTGCCCATTCGTCTGTCCAGAGCTTCTCGTCACTGGGGCTCACTCCTGAGTGGGGCCTGGGGCAGGAGGGAGGGACGAGGGGAGGAAGGGCGAGCGCCCACGTGAGAGAACCTGCCACCTCAGTGCCACTTGACATTCCTCGTCACCAGCAACATCTTGAGCCCCTGGATTCCCCTGTCCCACCAACTCTGCACTCCGTGGCCACCCTGTCCACCATAGGCACCCCCTGTTACAAGAAAAGCAGAAGCAGCAGCTGGGATCCCCCAACCTCAATCCTGCCATTAAATCCGCAAAC + S%$&()'*,')*)),-1-/(%#%$'*-0)%.&&&)*%+++..)*/&-*'00/0,*%/0**/1*$'-*.-)*''--,,0,.*102-0/0*/+,.&%+./.-,-*,***11-/1()*%05'-/)**)32/.4135*#+/-888699.6-2,53474:6)&243+227.4*4847856'(,6'*+5)$%$831)363+1&320--.'242861'1220$233450:55443534.579,,6189//42'53244063&02/%341:1.%032/,0(8$('*,-&--&*/36134-+5&4:(25,,4*#6++4'4-/:6*(.0.531507-7647356.-4&232)9-464+%5552%-*&'(652('+*-475938*%*$688/&,412%5/:36;93--$/0'467,*0.,#&%,2-*$+.%#0$,4,854%#$2/2546/.+*%-(-%*2-%.02.834*3"%8/-.2,+3,9/2(0/,&1/3 @rCer/2356/1718_60_CCS ATGGGCAGGCCTCCCCAGCCGTGTGTGTGAGCCCTGCTTGGACACAAGTGTTCGGAGGTGCCCCTCCGCCAGTTGACAGGGACCTTCAAACCTCGATGGTGATGCCAGGACACAGAGAGGACCAGATAGGTAGCAGAGACCAAGGCGCAGGGCGCTTCAGATGAGCAAGAGAACCCAGTCAAACCAGATATTCCAGTGGGCTGGAGGGACCCCAGACCCTCAGAGGGCTGCCCTGTGGTCTCCACAGTGCAGTCCCTCTGTATTCCCAGAGTGGATCGGGGCTTTCAGCCCCACCCTGATGCCTGCCTCCAGGATGGCTGGTTTAGTCTGAGTCCACGTCCAGACCCCTCTATTCTGCTCTGGGACAGCAGGACTTGAGGTCTTCCTGGGGGTGGGTATGGGGAAAATTTCTGCCTGGCACAACCTGCTCCAACCACTGCAAGTGATCACTCTTAGGCCCAGGGGAACACAATGACTGTCATTACTGATGCAGACCTGGCTGTGGAGAGCAGCTAATGTGTGGCCCAGAGAGCATGTCTGTGTGGCACACGTAGTGCATAGAATACGTGAGAGTTGCTCTAGCAGGGTGGGATCCTCACAGGATCGCCTGGGAGGTGAGGTGTGCGTGACCCACTGGTGGGAGAGGAATGAGTGTGCACACATAAATGGGCAGTGTGCATGCAACACACTTAGGGAGGAGTGGCCCAGAATTCAGCACACACACAAGGAGAGGACCCCAGATAGGAAAATAGGAAGGAGCAATCATTTGTAGATGGGTGAAAAGAATGAGGCGCAAGGGAGCGTGCACCAGGTGAGGTGAGCGTGTGCGCTCTTGGGGAAGGCCGGGCTCCCGTGCTGGGAGGCGCTGCCAGAGAGAAGAAAAAGGCAGCTACGGGTCGCCCTGGCTGGGCACTGGCGACGGGTCAGGGCGGTCAGGATCTCCAAACATGGACGTCCTCCCTCCAATCCAGAAGCTCCAAAAGGTGTCCTTAACAGCAAGGCTGTGCGGGGTACTCCTCCAGATGGAATCAGGAAGTGGAGACGCCATCCCAGGTGTGTGAGAGCGAGAGAACGAAAAGGAGACGGCAGTGTTGCAGCCCAGAGCCCCTGTCAGGGGACAGCCGGTGGGCAAAGCAGCCAGCCCACAGCCTTGTGGCTAGAGTGCAGTGCGGTGGGCCCTAGCTCCAAGAGCCCGGCACCCAGCTGGCAGGGTTGCCCATGCCCGCTGGCCACCTGCTCCATCCTTTAGGGTTCCACAGGCCCCTGACTGCACAGGGAGGCTGGGGTCAGCCTGGGCTCCCAGGCCTGAGGACATGCCTCCCACCAAATGTCCCTGCTCCAGTCCACTCCTGTCACCCCACGCTCTTCACTGGGAGAGAATGGAGGTGCTCGTGCTGGCCCTGGGTGGGAGCGGGAGTCCTGGTGAGACCCAGGTGAGATCGACCATCCTGCTCGCGCGGGGAACCCCTTTCCCACATTTGTGCTGTGTCATTGTTGCTCTGCTTCTTTCAATGTGTCAGTGCCTGGGGGAGGGAGGAGCACCCCCTCAGCCCCCTGAACCTGACCAAAAGCCATGGCTGTTGCTCCCCCCTTTGTATGATGCAAATGCTGAGATGTACAAAATCAACCATGACAACAAAGAAAAAGACTTGTACAGC + 6'15,24632$445:+254$123/4474==;:4.69;?864>=765*/201%/4.31,:99:7+462<7:>;;2::=<95/,*+<.;><7:./263://<<>67<5593;41<6;27649158:01807334267;8>::4;73&:94>=<(876?<><563374>8.93:;:?;673:9:;/4)2819/;8902&602&7;6(518*45-4&89;38.;87>:5<*59;9206'21()635.72350+7,33@,=??7<@7766?5=A;8<:?9:8=.758;?A-?5;BC@>B<>77>C=5A:8@=<;6:@=7@>B>/->0@;@<=<:&<=7'757===&1A?4;B95<=A<=@5=-8)=565'>;>9;.?8=8@9'<<19?:<63:?C.C@0<;9>%A8>;=664@C@@AE@E?7?>CD?;A?:=>?,8D=8=5?C9?>BD><:AAB5=A:46D1@E38=?BED@8@@=>@>=:>D3BAA?>%7?<9=:A3B?B:8GDE?:BB(BED+DD8:?:<6<>;>@=B=>FD4<=92$51@2?A2/@A:2<9@<=<4:@?3;:7>D>$@=C>AD:69:?E=56>C=>D>>AD&>?,ED@5-DB/7EF@E2>>@:8:;=@84=A7A-+9*955?C?%=A?=2=:BC;13774E;>+6)/C7BB?=F0A=>4.@CCA;?B/?E?4458:9BD@B:;787?FFE88E8::>&D1C,=0A>(=14@,;@7#8@?->B+BA=9:7,>BCA=>70&)78>(@>8><5:37C?6)0>DB-=?/=5=@/C?9695;7:E>:&>>%7;8?668;A?>C:8:?@B-7>?BB>9:7%23(<#>A7A>@;0>8;,85;7:,@4:/06:,=45%4437;8@?==::;7.<48;>@;7757;,,3.(*.&5:88+6=6+7>=@=84<3;?9=9=<;>,669;9;>54;=6>?69;4756&;>6=89;$@><@<995'8=@982=3437%8=><;;76=5===9A9<=B;A?=29;=<79>=4<;0346,=9'0670.1';1-44:>38.774+&4./1702*-1,7619:6/56.<757;<5339=9+><58<>1?:<6:=7;(>=>*9<:2<3:6>==3,;?988:=56:>:<<19==5705809>69.2=><=:6:79<1<51-690=?7;6764):;79896<2:>;=;6=6;?1:9:9577295:;:>?:<>96:99(:;6><>=<;=;80;158(;===81/:87656347./6798>89>880/2-65<<<.22-990>6<7765>23=67:?4<;=:7;+<;=:9/(2:9:;7:>=:;?9;9>>:89>>:796:>8=:.>8,-$;=;+764:9;=>=:0889/>??=6;54986;=-4<=78:;530739;:3==?=2;;<2>:55670:7<;>53:<>=.89567/;847918>8:?@3;>=@3@?7>B9?=9=>>6C>@>@>;-98:<;=984=7==72:=<=6>3=9:==8-81;693::38<>=<><>>=<;<-9:=;9==?<<-93>;:9;6:76:-2>4>.=46>>;<=<;:0<>=;<9?7A@>>>6'A;>88;;=3>>:=779><*?;ABACC><1<:9BB=AA@A6<5088=>C>>B@??;AA<9<>,==>A3;BC:A==5;=3B@@=<@B=@>63B:=A<=><@=B;B<>4=???;?@/9>A???<:;96<969::=?9;963;;>>>>==1=:=6?8=8(695:9<;0:8587:%7997>?2;2;6<:;;=6<<;<1;88/,30=1.=>9<86419=.9;=71346.66:8749;<;'7994305444.=9?:<:843469>39>=69;:6755+18/490:)8+21678<>;88869(6<9<>6=>8855>=>==:=77>5>8,0-04::6988399/9+5:55*484/4/:692:8;899:938.;94/316473631-365:2264,2--)399154.799:3566)6419654646:55;969::53988::6:61165%9-685:945948302797755'6959748;75943587665'336691479:97;699:44:::47785883;8::::98;928:95212:99+7477179:/46-52864&31462:*198+.$1884:678:8905863.79:0;8;7:96,97563535654027728886.52.8737246441437:868557:2583-858897708:87*08761,17-46628.5*-,+2$*/134&51550..2,2232,42035525566/12304356214-254415-54161533/20445-,464510-536505/05.56.4333*35105401*40,5455,42/0'1'-151103024'*2%1'4220$.61131500620.3131-1(,5/*2464163665665515425654462451316/05,334664433564666325346/45136456562255231444.4635013/4561305650466604/)46403/5555)6533/020/,4*456640.5343/)/224342+5+02205+/465,410/'03-/6 @rCer/2362/1572_57_CCS AAGAGGCCGCCCTCCTGCTGAGAAACTGTCACCAAATCCACCCAAACTGACAAAGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAGAAGGAAACAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGAAAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTGGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACATTCAACCTGGAAGGATCCCAGATCTATGAAGACTCCATCGTTTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAGGAGGAAGAGGAGGAAGAGTCAGAGTCGGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGAGAAAGGCCGGGACAAAGGAAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGTGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAATATGGACGTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAAAAAAACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAAAGATTGAAACAAACAAAAAAGCTTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACCTGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACTGATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCAATTTTCAAGGTTTTTATTTGTTCGGTATTGTTTTTTTTACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAGATTTCACCTGCATATACATTTTTCCATTTTATGCTCTATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAACATTGCTTAATTTTTTTGCTCTTGATTTTTAAAAAAGTTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTTCTTTTGTCACCCTGATCTCCTATGTTACCAATGTGTATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTCTTTGGTTGCAAGTCATAAGCCTGAGGCAAATAAAATTCCAGTAATTTC + D=DFDEG?FGED2@:?>BF:F?A3;6=GBFCA;=?3CBG>E;EE:B9A?GE;B@>B;E<@FFEEC4C=GG9C>7B:F2D;E>A>CCCED?FE9AAA@AB?D3E:ACA:?GGDBA2BBFEFE=E@;9BE;@D0D:AFAE?D>CFDBF>EDABEGEGDAEDACFCA>DE5EABACBCBGBFCEFADDF>4F@BDCBD2CECB-DCADDAEDGBEGGGD@A+G@CD6;GBDFEDFBBFEB=>CCD8E?FEGB?C>CD2D>DF@7C=A60+65B(B?DACC5FAC7D@=DE4:B:EB?@>;>5@HEC@@7FFIJH:ED?AC;AC9C>JFF>EDED2@>C6;DGAHCHHC9ACD?5?BEGCBDD>FFCE=H?FDEIH,HFH8GEC;GIIIADJGJIH@D@E5EGFIBIHB@CG=@?8EFCA>,IF;E9EHCCAGID7DGB4BD@BJHHGBG?C@@BAEI7E?HIE@BAE=&CDIA6CFIIGBED4FE=?3ECI9ID?EEADEGEJAIC=HACBJDIIDG?HIGGI?CIIIFJ9DGABBD,CFEG?GD:/AC9@>F>?CAC:CE@;52?FF9A898CB;E@D7E9D@5<=4D@ED6DACA9@@C@CC0?;CDGD:AE=5=B;BEFDBCA=D:9>?AEEFDBE&B=@:F?B;?C2@B:EEBDFCCB@BFCDC9DBB:6@A:=29BC@DEG?/C85CED3>8AD>??@CD=7BDBC>CDDCED+CD:<@588A?B?EA?9B@CDD??DE>?@D?EBCB@@=6A@EACC;>3:@*@@:FCDAAE->E>AA1CCDD+:5.6AC8=DB:CBD:9F>BFD@DDEA?CA>>@::@A9:>EFGCA=B@?B>?+DAAED?@A;B@FAF@EEDBD>DBFBB4;CAD5DEED7=GEE==2D8B@C=??B*@ @rCer/2364/1722_58_CCS ATGGGTGGCCCAACTGGAGATTACATGTCCTTCCGCTTTGAGCACTATCAGGACAACATCAGCCGTGTCTGCGAGATCCTCAGGCGCCTGACAGGCCGAGCCCGGGCCTGGGCAGCCCCTACCTTGATGGGGACCTGCCCCTGCCTGACGATTACGAGCTCTTCTGCCAGGATCTCAAGGAAGTTGTTCAAGACCCGAACAGTTTTGCTGAGTACCACGCCGTGGTTCCCTGTCCCCTGCCCCTGGCCTCCAGCCGGCTGCCAGTGCCCCTCAGCTGCCTGTGGTGAGGCAATACTTAGCTAGGTTCTTAGAGGGCCTGGCACTCGACATGGGTACTGCCCCCAGGTTTTTACCAGCCGCCATGGCCACCCTGCTGTGTCTGGTCCAACTCTATATCCAGAAGTGCTCTGCTCGAGCAGCAGCTGACCAAGGAGAGCACTCCTGGGCCCAAGGAGCCCCCAGTTCTGCCCAGTTCTGCATGTAGCTCCAAGCCTGGTCCTGTGGAACCAGCCTCTTCCCAGCCAGAGGAGGCAGCCCCCACACCTGAACCTAGACTATCGGAGTCAGCTAATCCTCCTGCCCAGAGACCAGACCCCGCTCATCCAGGGGTCCAAAACCCCAGAAAACAGAGGAGGAGGTTTGGAGACAGAGGGAGACCAGGAGGTGTCCTTAGGTACCCACAGTAGTGGTGGAGGCCCTGGAGACCCCAGGAGAGCCACCACTTTCTCCTGGGTTCTGAGCACAGCCCAGGCGGGAACAATGGTGCCCTCGTGATGAAGTGGCCTGTGTGGCTCAGGAGCCCCATAGTCCCCAGTCAAAGCAGAGTGGTGTCCCCAGATGACTTCAGACCCATAGCTGGGCAAGATGCTCTTGTTTTGGACTCTGCGCTGAGCAGAACCAGCTCCCCTACTCCAGCAGAGCTTGACCTCCACCCTGTGCCCTTTCCCTGCTCCTGCCTGCTCTCGGCTGCATCCCTGCCCATCTCCTGGGAGTGCCGTCCCACCCAGGCCTGCTCCCACGAGGGGGTCGTTTTGTAGGGCAACTCTCAGCAGATACTTGCGTCATCTTTGTCACCTCCACCCCATAAAACACCCCCCTTGGTGTCTTCCACACTGCTGGGACTGAACTGGGTCTGCACGTCTGTCCTGTTGGGACCTGGTTCCTGAATGAGGTTTCTGTGTCTGTCCCCTAACCCCACCCTCTCTGCTCCCTGTGATTTCTGTCCAGCTGGAATGTGAGGAAGGCTGCCTGGAGGAAGTAGTCACTTTGATTCTGCTGCATGAGTGGGATAGCATCTTGGCAGAAAATGATGTTTCCTGTGGGTTTGTTTACCAGCAGTCCTGGGCAACTGGGAGGTTTGGATGTAGGAAGATAGGATGCAAGCCCTTGCCAGGCTCAGCGGCAGGCATTCCCCTTTGTGTGTTAACGCTATAGTAGTCGGGCCTGGTGTTCTGAAGCAGGCTCCTCTTCCCCGCTGCTGTGCTGCTGTCCCCTGCGCGCTCTGCACTCGCATGCATCGTCGATTCAGCACTGAAGCCCAGTGATGTAAATGGCTCGGATCTCCCTCCTGGCGGACTATGACCCTCCAGGACAGGGGCTCTGTCTTAGTTAGCTCTGTGGTCTGGTACACAATTGGTGCTCATTAAACATGTGTTGGATTACTG + CCFC,BE9EG2B9BCD.EA@C:4DCDC9A=A=G=AD=ABBFC.FFC>/BEEBD>AD;F0F?DDEFA)GE*C+:GF+FFBCCC%8AGAGCBD@A:EABAACACFCB3C>CF?EGDF>CECGFEAG?CECAFAC?52>EFBDC2FGFBCB;AFBECCB7B=CFBC+CDD8EDEG8FFCFFC4@A>A@&9F?E<;47ACF6G.E4?E@AAC(-@D+?FD:CDCDCE>EFB@AEA<@@6BB5EGCFGEEB-?9A?@G9CEBD@F@E49BC+7@BA<112>6B(=A4F@BEEFFCEBA6ACFACBCFB>EC9CEAEFD8AFEC?BBEF;A=69;?BBD;==857CG;EG+G8G9>=DGGE/:CBCDBEFE*F:D:AEB;:AFDEC9>?3B6;@=9D>>>0@CBD=CA@G:AEE6GF53=ECFB@F=B@&EDCEAAD89B=F>EEGFDCA8:?DEDEBEABBAE=DFGE<=?)3@@?9@E.BFC@BE?EA?><9%A93DB=E@ABA@$??/CDE/FGE1?3DFD0D@FFD=@>5=F=B@#*.CFC@DEBGG@EDED2FG>CE4?2BD;B>DB:)8>8$=A;?87'?@7>==<@-:B*6?@A73:@@*@A=564A?6;A6;@AC<:>A3BAA(C?BC@@>@>?=B>A.AC,AB>*C;CC?@?>2@@@)?>@>5<;>?;B>B:B6BA5=;C>8>6=A053>B@(=A==AB=?3B;167>4CC<>?@3A7=;;<:<*A?>ABABC?B=>989$;CBAA;@C0BC8>=>CB??B==>?C;<9BB@8;*>-83BB=<<>>:83<>?99>=3>=4;?;:874<;:*??5=:2:94;66.=?8;=:84=<<+09>=6::;%8>??5877;=2315(106=?8<>>?1884(=?9=6=>;===(>?>>==<:'>>>><=*:89:<*:?;>>9>9$:6=7;7:=<7888261>>??=>><>=0:<::8:9$514<<,0987;<9'=6>3>8<2?5?<;<:>:4$:>>/>9:9?;>;=;+8866%<<5978:8>70:;:==(<='9??9<:::,?>896;;369<;6;;:'5:489<*;<<+::9:>>:::=)50.48>=5=:=7=(;6:3=3;=9:79>?7;>?3;58?9<9.:>3;>:=;63:=;;?7;5>2==9>9:7<7:5;==8/<5*4<36985646174<3/381;;9:4?=9<6??9<>5>:?<>?<9=886>=>>?=28?=>:=:-8?<9>+5.<::>>?=?8=94=?8=6==9+9<;%:;>=,0;159=<>>?6=9:+=<<0;63+29,9>>><<4>2><;>=>;5<;>>>>>-?;>?>>9>9>=9=6==79-75<6>;;<=<<*<9:<379;>8<=<<>;8<;&:998.96>=<>>=83694<8=;5<=8<>?>?<>98>=::9=60;;%76.*<;>;==08<3<748;=>>??;3:>27?;9?62=:7896??=648:?5=<:=;8(2842:79=4;=?><86766=86(;=>?:<9<:8>=?=>8;>99>==07=0><>>?>?<;=>>6-=82 @rCer/2365/1821_61_CCS ATGGGGGTCGCTGTCTGGGCTGCCCCAGTGGCTGTCGGCGCACTTCCGGGAACGCCTGGGAACCTCAGTAACCGCCTGATAGCGGCGCTGCCAGCTGGCCGGCGCGGGCTGCGAAGCGGGTGAGAGCGCAGGCCAGGCCAAAGCCCTGGTAGCCGCGCGGCGCGGGCCTGGGTCTGCGGCCATGGGGGCGTCCGCGCGGCTGCTGCGAGCGGTGATCATGGGGGCCCCGGGCTCGGGCAAGGGCACCGTGTCGTCGCGCATCACCACACACTTCCAGCTGAAGCACCTCTCCAGCGGGGACCTGCTCCGGGACAACATGCTGCGGGGCACAGAAATTGGCGTGTTAGCCAAGGCTTTCATTGACCAAGGGAAACTCATCCCAGATGATGTCATGACTCGGCTGGCCCTTCATGAGCTGAAAAATCTCACCCAGTATAGCTGGCTGTTGGATGGTTTTCCAAGGACCCTTGCACAGGCAGAAGCCCTAGACAGAGCTTATCAAATCGACACAGTGATTAACCTGAATGTGCCCTTTGAGGTCATTAAACAACGCCTTACTGCTCGCTGGATTCATCCCGCCAGTGGCCGAGTCTACAACATTGAATTCAACCCTCCCAAAACTGTGGGCATTGATGACCTGACTGGGGAGCCTCTCATTCAGCGTGAGGATGATAAACCAGAGACGGTTATCAAGAGACTAAAGGCTTATGAAGACCAAACAAAGCCAGTCCTGGAATATTACCAGAAAAAAAGGAGTGTTGGAAACATTCTCCGGAACAGAAACTAATAAGATTTGGCCCTATGTGTATTGCTTTCCTACAAACTAAAGTTCCACAAACAAGCCAGAAAGCTTCAGTTACTCCATGAGGAGAAATGTGTGTAACTATTAATAGTAAGATGGGCAAACCTCCTAGTCCTTCCATTTAGAAGCTGCTTTTCCTAAGACTTCCAGTATGTATGAATTCTTTGAAAATTATATTACTTTTATTTCTATTGATTTTATTCTGGATACTAAGGATGTGCCAAATGAGTCGGATACTAAGATTCATCCTTTGAAGTCATCTGGTGTTTTATGCAGTTATCCTCAAAAACATCAGCGATGTCTGAACTTTTCAAACATCTGTTAGAGCAAAATTGAAAGAGCATTTGGTAGTAGTCTTTTTGTTCAGTTAACAAGTGGTTGATAAAATTTCCATATTTTTCTGGAAAAGTTTAAAAAAAGTTACATGTCATTTGGAGAAAATATATAGTCAGAAATTTTTGCATAGATTGATGCAAAAAAGACATTTCTAGCATTGTGGAACATGGTGAGACACTATATAAAATTTCAGAAAGAAAGCAACTGGATTTACAGATTTATTGTGAGACACAAATTCACTGCTGCCTTTACACTAAGAAATGTATATGTTAACCATATATGCTGTATTTATTTTGTTAAGCATACTTTTAGTTTACTCAGAATTTTCAATTTGCTATAAAAATGTATCAATTAGCATATAGAAAAATATTACTTTAAGATGACTTGTTTCCTTTGAAAATACATATGTACTGAGGGTTATGATTTATGTCAGAAATTGACATAAGTGCTTTTACAAGCACCAAAGTTGAATGAATTTTCAACAAAATGTAATTCAAGTCTATGTTTTCAGATGTGACTCAGGTTAAGAAATGTGTTTTAGGATCTACTTGCTGGTTTTTCTTTTTGATCCAAATGTATGATCTGCCCTGATAAATAACAAGTTATAGTACCATCTCCCCCG + EFDGGD=@9C:=@=A@C@9B>;AFG9:6@E3CCD??B/@?EFEDCFEF:@FBEB@?B;A9E72=
B@8?C@BC?BFD4C8AAE?;>@G=@GEF@9AC@FG@B?CG@9>=ABDE=G;AAFEEC1@>3=1B=AB?@DEE@@BB<EE9@C8>?1<)C?BB?B2B@@A==@.5<3@9(3<;C?>0C;=7@=>C9A79>;>2:?;@>BCAA2B??A==AA=:6'?=<+?=ACB8>@?>=8<0?>>A>987?5=>>=@=>7==86;/7;?<>>@:C;?C4CC;38B<8C@8BC@C@9A>;>=5;9:41==869>A?@=;B@;@CB?87:6:=)==<:9=@:?=6+::==;A@CAA@:B5>7@9@9?3?@<9A?98:2???1A89?;@AC>?>?A@=8.;?C=66??=6BA>=BAB?BB:BA<>BC>CCA@1:??B>CAB>AA8@>9:<.BA<:>8@5<;>=>A2;@A@=<=C-B<<0??;=B?CA@::<=>B9=@B9@?<<68?@A@?8;=<2999==9@:A>@><7:2<6;<.<946/169A=CCC<@3.@80<8>>=>='<878;@<6;6;A*4:A:=BC><7CA@;B?A;>>A7AB8B@@?(=5B@<759,-*.(#%+/5.#-+8@>A>1>=FC:B@>GEEAFF8DG=FFBD@EEDFF=E>@>EC6EG9=?B;EBCBBEFCB9ADA(AFF2CACC8BAFB=8:GDFCDC=2ECAEBCA6AFFAD:GG;<>6<6DA?:?.=?<=C6C:FD6C>DC04C8?DA=>:4GBCEBCE1?;C=>BG@B>B>B?CC@@/ECCD1ACFEFCEA=BF;AFFF/DD<-D=DA9>B;A82EADED3E;BEC:<9ACADE9GACACEEB@6@DFF2FDEFDCBA;='BD7DFE=GGDGC?EB@>?7*9+F?BCF2C@?/9DEFFD0:ECEGED99D@:@$9:EEGGF=DCA;@A>BCFCEB7GGEE5BEEDBGBCF?FB;AEB=>=<?5B=7BC@C>CEEBDBE@<8@EF9@F>B9;CBFE?CDC03@EC?CDDFCAF6AB>$>D9CE7=?EDCFFCF1@EDCFGGB>2;AD>D:@;CEEBE/DG@?:A@EAB5D?FDB=)8=@BDBDCEBB5EACA>DDE8CFEFD4CC1CD9DFAA?B3;:B,B>+ABEA4@A:@?E=B>7E=C@?8DED5,0:DGDCBAEA5EDCCE4<::DC4BFCFDEC7>B2AE9DD6DEB9E=@EA6?BA>ECCEEE=@F>FC:AEB@B;CE?DCBD@C@?<:&@ @rCer/2366/1962_58_CCS ATGGGGGGGCGTGGGGCCATGGTGGCCTTGCGGGCGGGGAAGAAGAGTTTTCTCCGCGCTCTCAGCCGCTCCTTCGTCTGCCGCGGCTGTCAACTCGCTCCGGAGCGCGGGCGCCGAGCGCAGGGATACGGCGCCCAGCGGCGTATCAAGATTCTGCCCTCCAAGAAAGTCTTGCCATGACTGGATAGGACCCCCAGACAAATATTCAAACTTCGACCTGTTCACTTTTACATACCTGAAAATGAATCGCCATCGGAACAAAAGCTTAGAAAATTAAGACAAGAAACACAAGAATGGAATCAACAGTTCTGGGCAAACCAGAATTTGACTTTTAGTAAGGAAAAAGAAGAATTTATTCACTTGAGACTAAAAACTAAAGGCCTGGGCCTGAGAACTGAATCAGGTTCAGAAGGCAACATTGAATGCAGAAGAAATGGCAGACTTTTTACAAGGAATTTTTAAGCAAAAATTTTCAGAAGCACATGTATTATAACAGAGACTGGTACACAAGCGCAATTTTGCCATCACCTTCTTCATGGGAAAAGTGGCCCTGGAAAGGATTTGGAACAAGCTTAAACAGAAACAAAAGAAGAGCAACAACTAGGAGTCTACTCTGACCCAGCCAGAGTCCAGGTTTCCACAGGAAGCAGATGGTTAGAGGAGCTCCTTTTACAGGAGCTCTGAGAAAAACTGGAACTGATCTCAAGAAGCCCCACATCTCCCTAAGGGGCCCATGGCTTGTTTGGGGGCAGGGTGGGTCCTGGGGCACTGTGGGCCGCCTGCCTGCCGATGTGGGCTCTAGGCCAGCTTGTTGTCACGGACACGGTGTCAAATAAAGCCCAAGCACTGGGTGCCCGCTTTCTCTGTTTCAAATTATACCCATTCAAAACAGAACGATTTAAAAATACTGGCCGGCACAGTGGCTCACGCCTGTAATCCAGCACTTTGGGAGGCGAAGGCGGGCGGATCACTTAAGGTCAGGAGTTCGAGATCAGCCTGGACAACATGGCAAATACAAAAAATTAGCTGGGCATGCTGGCACGCACCTGTAATCCCAGCTGCTCTGGAGGCTGAGGCACGAGAGGCTTGAACCCAGGAGGCGGAGGTTGCAGTGATCCAAGATCGCACCACTGCACTCCAGCCTAAAGACCGAGGGAGACTCTGTATCCAAAAATAATGATAATAAATAAATAAATAAATAAAAAATACTAATAAAGTTTTACTGGAAAAAAAAGTCTGCTGACGGGAATGATGTGGAAGCTGACTGCCAAGCCGTCGGTGTGCTGGCCATGGGGTCGGCACCACCCTGGCTGGGAGTCATCGGCTGGTGGGTCCTCACAGGCTCATCCTGGGATGCGGTTGCGGTGTGAGTCAGCGGCTGGTGGGTTCTCACGGGCTCATCCTGGATGCGGTGCAGTGTGAGGACGTGAAAGCAAATTCAGCATCTGGTGGGTCCTCACAGGCTCATCCTGGATGCGGTGCGTGCCTGTGATCCCGGCTACTCGGGAGGCTGAAGCATGAGACTCGCTTGAACCCGGCAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGTCTTTTTTTTTTTTTTTTGAGACTGTCTCAAAAAAAGAAAAAGATTATTCTAGGCCTGGCATGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGTGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACTTCATCTCTACTAAAAATATAAAAACTAGCCAGGCGTGGCAACATGCGTGTAGGTCCCAGCTACTTCAGAGGCTGAGGCAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATATGCACCACTATACTCCAGCCTGAGTGACAGAGCAAGTCTCCATCC + ..-/1555'22152+(**21541311.-%4552(/0-+%6350/-'32.2)3+2.054050521+3/.+240520/10*1.,,.+$++025610%-//.-*')/0//1-.(503,/+*/3+*56.-*)'.+$&+)$$&%'%,-*(%)+$*'(&*'&&'&$#"$$+-)&*')*$-.)+%-&)'%&)**.-/0-+)),+,0/.*/..(),-*#*(&.*5/466040/4,-'/.-,62+$/-15238720354-2/03*-23490/,+0/50*.7%33/343/+'(55(-131.20+40,-*26101152-.,,,&),6,9.0*129-+-43*67/44,1(4+.543(//-/6,*.*18)6444-.5666,4445(603/.627420.04*---00(12/,-0/05(&',-'(%-.0/&(.'*-()04.1+.311//11*13135.02,$10423.3)420*&.*+044-3+(,&%.0/2(-881.=5/+1%/,)/2=;596704-,5*.)3'*-:<34-.8/11-+0-,2+//::596376-.6.%4:/5;;29:6<948:8990216(467=;:0*++5169925998'17+487<=84:68*6:14366436166<:34%5<9)66647:.4614<+7299-5372997048758/12022984243443-4;85158546876499:7/2652/1406466755,(/*)---,6285,3662.2+01.),2%-.9699-75663675+2474,&46,2:29;;;3:::5153261011/2756151/,*386.5550615:7344-,693624,,*4/+//3&/.30.-011++($465---218.34743040/-04;55762284-443,*-.3/14'7201435(87,8355-651341/).027315'98726679;67'9::96078110)5%4:6544925676738:795+561,8444343(5,346/1:90/5:;7.::9966:7385;6438-2-,3.557%6943.,..%6028:74415*22.090-3,$./(,8902&7:4498679/28.75/:7495867.8797943.163551:27080/7615/*1265353:864/4--*,+/+,*//&.--3265997525.39:&/21,*140+446/7662-2.:4899/+*114,&15+/16)864+000/1(**'-/15(&+)966-*6:39883&3)015/369948,66133225+.3(+8-0/104,7353416302.16210.///+$4'/3686350-331221&0),(0../0.,''',*-11'#(-+,0),'*.),3.812*-135/./'-0)4-0,*($#'()'(('#0..+&'&)(./162440,662473,5,+2433)0'1%&*44220-4+/-.+510,(76)133/23)2079*613+&6*1)..2/24748893353-06:653,0..343220,../2'(+,.*5-$1+&*/101(&)&(10,*)$#/-,205..6/2,/944702:65:67346/:3.25)35//*-948,2,45--+*31,2+01+-124521/,,*,*'($*040)1-'#$-/,/21*'/-)-530/'*1011&231,5-%&)'3/4-)3310-0&/5-04/-4+.)5234,*2,53-403//).1&)6)64944853..238.2953,815/663129668:8464604894+49:975708599872.48&425854544//-,+%'',&,08*/451452.+/.-5*-&%211,,,.1.,0.016-52-0/32/.0430&0252613.3,,/--/122.-521120.1,4642,565/+.-+(-,.++-/+/+#(*).***1)-%,+'-)-+*),.10,+.-)110,)-0,--,320* @rCer/2368/800_54_CCS GCACGATAAAACCAAACTGGCTTCTGGAAAACTGGAAGGTTTTGGTGCCTTTGAACGCTCAATTTTGACTCAAATCGATCATATTCTGATGGACAAGGAGAGATTACTTCGAAGGACACAGACCAAGCGCTCTGTCTATCGAGTTCTTGGCAAACCTGAGGCAGCAGCTCAGCCTGTCCAGAGAGTTTTGCAGGGGAACCGGAGATCCTTCCTCAAGCTCTGCCAATGCTCATCTGAGGACTTGGATGAAGAAATCTTTGATGATGATGACTTTTACCACAGCTCCTTCGAGAACTCATAGAACGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGCAGGAAACTTCGTTTCATGTCTTAGCAACTACTGAGTTTCATGGCACCTATTGACCATACTACAATGAATGATGACGCCAGGACAGAACTGTACCTCTCTTTTTGGCCAGCTCCACTCCTCCCGACGAGGCATGGGGATTGACATCGCCCACCTCCGACACCCAGCGGGCGCCTTGCTGGTGCGGCTGGTCCAATGGAGAAACCAGTGACTTATGGACTGAGTTAGTAGGAAGCCCTGGGAAGGTGCTGTGTTCCGAACCTGTGCTAAACATGCAAGGGCGCTGTCCGCCAACCCGCTTTAAACACCACAAATAAAGAGCACTGTTACTG + 00--,+*010(,*01,//1+-1-)0,+55..23,'.,,'-08*93/%((+1&4,)11+9292889)65358::.9878324621&-+/35;3,43)856.,+-712,:485:07-7&771979-80+775:99:6,45/421(9/68+3&789*9/1.62&1350347342+6/42$1%.-,(+.200$.$)310(613-5,3/-56.1)/'2..%,32/0/3&-321..1++-,,&,+1.4+72.,*1*/39-1384&/4114-,-&02521//.+//%35022*0*-4.(4./301//*2,%$$)1/./0,/2/.2//01%11'/%///+(0*'.-640./*%/(-(3././%,4,+45*06.)141&/+/+.+152210(533022/0.-&10,&24161-1$/5(50410**0(0+4/(.).''24&0.-*+#2-..0.#+.--(*-+43(-504*.,2-),-))46,+2/,/1.3.0262315200131*01)3-515142052&'#(-&1)*,%)%.).5312+2-%/&)-1%+.,*'3.$,340.(.1%1/0/21334'.1(.1*0&.-41+0/./0#%),%4-&%..,*.$&$&$'%./,$'41+/$2613/0-1./.5'..-$.+(--(+(.4031%-.110)+-4*630*104441)54010602(.&+'$+2#*,11046/51*2),2.-/$*0$3-31(/*,1(620*1+).+10(201)4-/,,/*.4-5'03 @rCer/2370/119_60_CCS CCAAGGTAGGGAAAAAGCACCTTAAAGAAAAGATATCAAAGCTGGAAGAAAAAAAAGAC + 8)013--860&1369+309753+9716:8=/(441376;)<-07+<1'<98:9:7%3-0 @rCer/2372/0_1558_CCS GGACGGTGGCCAGGGATCAGGCAGCGACTCAGGCGCCCTGAGTGTGCCCCAGCCGCCATGGCCGGCTGCTGCAGGCGTCCTGCCTGCTCTCCCTGCTCCTGGCCGGCTTCCTCCCGCAGAGCCGGGGACAAGATAAGTCGAAGATGGACTGCCATGTGGCGTGAGCGGCACATTTACGAGTACGGAGCCCTCACCATTGATGGGAGGAGTACATCCCCTTCAAGCAGTACATTGGCAAATACGTCCTCTTTGTCAACGTGGCAGCTACTGAGGCCTGACGGGCAATACATTGAACTGAATGCACTACAAGAAGAGCTTGCACCATTTGTCTGGTCCTTCTCGGCTTTCCCTGCAACCAATTTGGAAAACAGGAACCAGGCGAGAACTCAGAGATCCTTCCCAGCCTCAAGTATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTCCAGCTCTTTGAGAAAGGGATGTGAATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCGGAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTCCACGACATCCGCTGGAACTTGAGAAGTTCCTGTGGGCCAGATGTATACCTGTCATGCGCTGCACCACCGGACCACGATCAGCAATGTCAAGATGGACATCCTATCCTACATGAGGCGGCAGCAGCCCTGGGGTCAAGAGGAAGTAACTGAAGGCTGTCTCATCCCATGTCCACCATGTAGGGAGGGACTTTGTTCAGGAAGGAATCCGTGTCTCCAACCACACTATCTACCCACCACAGACCCTTTCCTATCACTCAAGGCCCCAGCCTGTACAAATGGATGCATACAGTTCTGTGTCTGTACTGCCAGGCATGTGAGTGTGGGTGCATGTGGGTGTTTACACACAGGCCTACAGGTGTGCGTGACTGTGTGTGTGTATGGGTGTACAGCCACGTGTCTACCTATGTGTCTTTCTGGAATGTGTGCCATCTGTGTGCCTGCAGCTGTGTAATGCTGGAGAATAACCACTTTCTCTCCAGTTCTCCATTCCAATGATGATAGTTCACTTACACCTAAACCAAAGGAAAAACCAGCTCGAGGTCCAATTGTTCTGCTGTAATCGATACTTCAACCTTGGGCCAGCATCTCCCACTGCCTCCAAATATTAGTAACTACCACTGACGTCCCAGAAGTTTCTGGGTCTACCACACTGCCCAATCCCAACTCCTCTTCCTGAAGGCCCTCCAAGGCTACATCCCAGCCACAGTTCTCCTGAGAGAGATCAACCTCCTGAGATCACCAAGACAGATGTGAGAGCAAGGGCCACGTACCCCATGTCAGGGGTGGCGTCTTCATGAGGGAGGGGCCCAAAGCCCTTGTGGGCGACCTCCCCTGAGCTGTCTGAGGGGCCAGCTCTTAGTGCATTCAGGCTAAGGCCCTGGGCAGGATGCCACCCCTGCTGCTTCAGAGGATGTGCCCTCTCCCCTCACTGGTCCATTGGCATGAGACTCACCCCCTGTCTGCCCAGTAAAAGCCTTTCTGC + S*12-,5,:(77%-3+492'3836-69:;:>*;54+A5-<:>>154&<==5(%:++65*1/#@2AA9=8DF*14BA@E+D@6)A?46;9?1/<=>9?:8?0:1='893??GC%A;?<;>8<4?&=DBB:6C;3@2.@7=-)*?+,1BG@D5;:=)B7DGFH7?BFB99BC71IEFCG:>A>:>C>(:?D8D:D0=B&01E<8@BH@97,@0@9B@;,C*$9?FF:ACIG=IDGC8?DEBFGI@F5J7C;38;@0DH:HECE36F:?AFI@?DD699E-IH;H.IB9ECCHBE;D=DDC3ED5EE+CE;AIHE%JJJCE%B%B:D:IB4KKEB83K1$>9IHBIHB=D:>?HJ*D?4FFFCHEH>E?>90C;+>;>3DBFCJG:A?BHC085B<6AE;A;B1@<&CC?BG@?5ED9E'A:;A=8D;HG&<@DCI@=B4D@E?0>46,$A5=>=C?->,<>&=-@8(3@67@,&=C>*BD@D@B>8;>:A)==1<92B7EE4>:BFBF<97=3?<,:AEGF=A8DB3GA>:9@5@B@=6<*94,6:>)5,10798&<<563:>?=<96>6>1<)2=:C7A:8:><1/=@+><:01:585+8>866($611&278?-?A7,8:7/87B8<5766;<5?29;#/-3+:7,4;331558)878&::894=$64(:<0A<:97:79:7?)@+>=:2'':;*93756.13<;6727&672=;2;679;567*:/664914-20+:8:775>??7893-3..451317.@;5:8<<0++=;6:6=42(=875+8452>51=:,7+<.96;7386.A<>=::85=90?7;8:<:>B?;A-;>A==?>BB<>;-:2<0$4>=;;@?88A94>;?5:;.;,74B:4;@79?8:6:/:20?>>>9@82B4$4+;BAB(4:;;69=146:,94?95=3=7;?7A<61=<98.2605=7<%#.<088<;7)=8$*;@9?,A8,36>==9<9%6>121/2..%8<482??-B?@?*9046414:>977;B&950<<%>B<@A<2/..5>:DB@;@#?3EC70B377>09=>5*%:8:('C;<;6?A>=&C@AB@>97;<442<'7<%>05:9=E>8"8<><,7:ABD=B>=>AB??8)BA;BB@&=:0$36E=.?:==9.;$39FDACD1DC@AD=A@>@@C;C=?A>@CC643892>66&=66+@DF:+/1.=)68&88677936?24/4:33A83:<7(11090'::9>=8@?7B3A4<9:6=484:41;;=A5;61:?&A=3;B68=?;697????A4 @rCer/2373/25_1890_CCS ATGGGGAGTCATGTGACCGGCAATGGCGGCGCTGACGAGAGTCCTGGTCAGCTGAGTGGAAATAGAAGGATTTCTGCTGCCATCATCTTCCATGGGCTTCCCAGCTCACACGACCTACAAGTAGGGAGCAGGGAAAAAAGAGTGAGCCTGCATGCCAATTCTAAGCTCTTCAGGATCAAATGTCGTTCGTCCTGTCCAGAATGGCAGCCTGTGGAGGCACCTGCAAGAACAAAGTGACTGTCTCCAAGCCTGTGTGGGACTTCCTGAGCAAAGAGACCCCAGCCCGGCTGGCCCGGCTTCGGGAGGAGCATCGTGTGTCCATCCTCATAGATGGCGAGACTTCTGACATCTATGTTCTCCAGCTTTCCCCACAGGGCCCTCCCCCGGCCCCTCCCAATGGGCTCTACCTAGCCCGGAAGGCTCTTAAGGGGCTGCTAAAAGAGGCAGAGAAAGAGCTGAAGAAAGCTCAGAGGCAGGGGGAGCTGATGGGCTGCCTGGCTCTGGGGGGTGGAGGGGAGCACCCTGAGATGCACCGCGCAGGCCCACCCCCTCTCCGAGCAGCCCCACTTCTGCCCCAGGGGCTCGGGGGCTCCCCCCTCCTCCTCCCCCCCTGCCCCCACCTCTTCCTCCTCGCCTTCGGGAGGAGGCAGAAGAGCAGGAGAGCACCTGCCCCATCTGTCTGGGGGAGATCCAGAATGCCAAGACATTGGAGAAGTGCCGGCATTCATTCTGCGAGGGCTGCATCACCCGGCTCTGCAGGTGAAAAAGGCCTGCCCCATGTGCGGCCGCTTCTATGGGCAGCTGGTGGGCAACCAGCCCCAGAATGGGCGGATGCTGGTCTCTAAGGACGCCACCCTCCTACTACCCAGCTATGAGAAGTATGGCACCATTGTCATCCAGTACGTCTTCCCGCCCGGTGTCCAGGGGGCTGAACACCCAAACCCAGGAGTTCGGTATCCTGGCACCACACGGGTGGCCTACCTCCCGGACTGCCCTGAGGGCAACAAGGTGCTGACCCTGTTCCGCAAGGCGTTTGACCAGCGTCTCACCTTCACTATCGGCACGTCCATGACCACAGGGAGACCGAATGTCATCACCTGGAATGACATCCACCACAAGACCAGCTGCACAGGGGACCCCAGCTGTTTGGGTACCCAGACCCTACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACAGATGACTGAAGGACATCGCCTTTGCCAAGGCCCCTGCTGTCCACCTCTACTAGGACCCAGCAGAAGCCTCTTTCTCCTCTCTGCCCCCTGCCCCCACAACACACCTGTAGGGGACCTGTCTGACTGGGAAGGGCGTTCTGAGAGGGAGGGGGCAATCCCTTCCCCCATCCCCCACCGGCCAAGTGTTTCAATGCAGTGTGAGCCACTCCCTTCTGGCAGAGGCCGACCTCCAAGGCTCTGTTCTCCACTCCCGGTGTACATATACTCCCCGTTTCCCTGCCCCTCCAATGCCCTTGGCTTTTTCTGGTGTGCTGTGCTCCATGACCAAGCAGAGAAAGGACCTAGGGTGGGGAAGGGAGGGTCTCTTGATTCCCAACTGCCCCCACATACTGCTTCACCGCTGAACTTAGGGTGCTGGAGAGGAGGAATTGGGCTGATATGAGCTCCCCACACCCCCCATGGAGCCGGCTGTGTGTGTTCATCAGATACAGTTCTCCCTTAACCTTGTCCTTTCTTTCCTGTGTCCCAGTCTCCGTCAGTCTGTCTTTCTCCGCTCTTCTCTGACCCCTGTGAGGAACCTCCTTACCCTGTTCTGGGAATCGCTGCCAGACTGTAGCTTTTAATTTAATAAAAATAAAGTAAAATATGCAACTC + 7:9?;;'8C??3C??48<85@5<=8C>;C?A7BB;8<:ABF?87:?@CAE:.:22=484$6:887+*:<=3C>>;>=7@9B@>CA>?:B4A<89B@93D9?EBBB>A;D0;:,/=?CB2C:4:7A=;??;6;?/@>B;:8)58@=A6A8<>63;>@4;:>$74(:2;A:A@3@9>;:B><>>?>75;A=@A7C:9@>:5/EB2=68E@@<=1??B=<67@>DB@A,8==>:(9:;77>3BCDC>5@<1<@@4C9A?1:>5;A0C;5FGA8>7>>?<:=95>:6)8B9=@1<9=CD78>@=>ACCCD>@1DI+9>A:9?=FBCFFA4C?F74B-9D8:18A59404;;$?2BDF(?15/DAG>IBF@(<8C:=3>/B7?:3@CA>;&3;@8<=0@58>C@D.?FEAB5;<;?(9:>==CCDD.:>-<1>,&43->>=;9;A@A;5A>=DE9?FA;>0DAD8AB6:EDCB8@>;8>;JB:;BD?E=?A8?BGD7:A>DI>:4>C>@F4D9@GHG@FF1D9C5ACF9A+>BFGB@B,<6@8EC?DE;=B6%;@@@B=DED>AG5DGCBFJ>>F>AE@?$=DE>EI=AG7HIDFI6@?3FB;C:<>@D=6HFGH??GFBJABHFH;DHC=D8@D==2IJGFBHC?8:8I653G8?HHGJ7.:>?==H@E?=;E20=E5@6@F9>8AC@$/;;;EGI?A?IBCC4BFAAFCD;AI)ADBB8DFFCE3=>C2=@F?F<9?/8B:G=K-@'CHJ@JBBB?A>+EEIJ:66D@DEHBJ=75E@31>7GHI=AIH9;,@7IG;5+?>HA>BH?KIKKIDH@D8AB'>4+4GE=D;6=EEG8GFGIBF@EG.BEJDIBB>KJIKHGEJKJEJKGIFCJH3FE?IIB-JKC?<==E@:<GCD<=E=DG;GG0;@FI@?KHE-FJFFFCF;K=HEKJKJ3CC87?CBD>DJAIKEE@GHCIGIB3CD3,BJ>J1CFJKDKCK<(KGDFEGIGKIGJABJKKJGEJJ=IKAJ4HCJIJJGEJJKK?CKGFAB6?AG367B;;;==E<>EFC@>2CF:=%?4B?=6EE>>HCB;HDGD;;-487<71@F@BD@FB3>GEHAHF<>@B5C(AA>.>?>DHCHBIAIF?FIHEIGFIH5F=BH8HGBIGGHHIFG91JFF8@F=CB<=@BFF@JJ(=>78@-AB3HBF&D25D@H4?GEEDAE;HDGA99>)E>4@FD?D5CJF:'3:6<;BFD=C=EC @rCer/2376/1687_52_CCS ATGGGGCGTCTGCTGTGCTCCGCGCGCCTTTACGACCGGAGTCCCTGAGTAGGCGCTTCCGGCCATTCATACTGCAGTCGGTCAGTATTCGGTTGTTGGATTCTGTGCGCTCTCGGACCCGAAGGTGACGGCGCCGCTAGGATGAAGCTCGTGAGATTTTGATGAAATTGAGTCATGAAACTGTAACCATTGAATTGAAGAACGGAACACAGGTCCATGGAACAATCACAGTGTGGATGTCAGCATGATACACATCTTAAAGCTGTGAAAATGACCCTGAAGAACAGAGAACTGTACAGCTGGAAACGCTGAGTATTCGAGGAAATAACATTCGGTATTTTATTCTACCAGACAGTTTACCTCTGGATACACTACTTGTGGATGTTGAACCTAAGGTGAAATCTAAGAAAAGGGAAGCTGTTGCAGGAAGAGGCAGAGGCAGAGGAAGAGGAAGAGGACGTGGCCGTGGCAGAGGAAGAGGGGGTCCTAGGCGATAATGTCTCTCAAGATTACTGTTTCAAAGTCATACGGATTTGGGATATTTTTGTACAGGTTGTGTTTGTTTATGTCAGTTTTTAATAAACATAAATGTGGATAGAGCTGTCTATTTAGTATATCAAAGTTTAGTAGTTTCCTCCACATTCACAAAATTACCACAGTGAGAGCTAAGCATTTCTACTGGCAGTTTCATTTTTAGATGATCAGATTTTAAGTTTTTCAACTAAAATTTTCTTTTTATGATGAATAAGGTTAAAAGAAAAGCTTTAGACAAATTTAGTTTGGCAGAGTTTAATTGAGCAAAGGACAATTCACAAATCAGGTAGCCCTGAAGCATAATAGGTTCAGAGGCTTCAGCCAGCTGTGTAGTTGATGTAGATTTGTGAACAGAAGGAAAGTGATGTATGGAAAATGAAAGTAAGATACAGCAACAGCCATATTAGTTACAGTTCAGTGTTTGCCTTATTGAATATGGTTTGAACAGTTTGCTGCTTTGGTTGGCTGAAACTTAGTGATTGGCACGAGAGTAAGGTACAGTCTGTTTACACATCCAGTTAGGCTACAGTTCTATGTACTGAGAAACCTTTAAGCTGAACTTGAGATATGTAAGGACTTTAGGCTAAACTTAACATACATATAGAATATATACCCTTTTACTTGACATGCACTAAATATGCATTTTACTGCTGACTTCATTCTGTGGCACCTACCACAGGGGAAATAAGAAGTTCGTTTTGGTATTTTGGAAACTAAAGTCCTTATGGGATGGGTCTAGAATTGATTCTCCTTTCCTGAGTTTTACTCTACGGAGTCTTAGGTACCTGGTAAAAGTTGTCTCTAAATTAAGGTTATTGCTTTGTTGTCTAGCTGCTAATGTGTCACTTTTTTTTCTTTTGCTTTTTAATCAGTTCTTAGTAGGATATAGTTTTATGTTTCCAAGTTGAAACTTGGAGTTAATGGTCACTAGATTAGCAGTTACGAGCCGTGTTAAATCTCTGTTAATGTGTAGTGTACCTGTCAGTGCCTCCTTTGTTAAGGGGTTCTTTGAGAACAAAAGAGAAAAGACCTACTTTATTGACAGCAAAACTGTTCTAATTGTTAATAGGATTTTTAAAAATTGTTTTTGATTTGTTAAGC + BIKHK40BKHIKKHJCAF;A4DIF=1F(:A7DD?=FBGEBA-I-:,>DEBB9@?I2AJJ*EF2E1;;JJHFGFG7HF:*H3ECJJJHKDKE1DFGIIKKAE3IIKGI;E@:HG'5A,@A?FGJJIKCKKD-IKBH+AIKJ;FDEIBEFII.KGD>HJ:IIDJ6F9+2@-DFHB<;<8:BFH;IEGECF?GKI=HIK1:I0<5@JIBHJI3KG9=I>GIIJ+DCB89I2F&<5:IJ?JJK=EEFCCHDIIJE*@-IJK>DGGFF/B<>H%D:HIDFKECA4CFHE?GEA:<:,?C@9HKG$=CCFHIA8I?GH=BEFG>FF=IHA;<1CB=HICDGHI-=3DGCCC3:E8D??=6%@'*CB+I98EE3:;D1@D:BC;CA@8D=BAD?E+3B5>B@B'>DGAE;I1HEGI?@E?HHC=>=F>FJI1CHGG:EAE0;1IED3ACB.A=;>5,E:B?<5F>?=?FGA>?4GFII>D@54*;4&?A5F@D0FBDFID7BEG4F-DDB1C:@@CGH?FG<C83+-<1;4B3:89/9??C<;GF5AEG.@BF1EFGE@@<=DFFA89>9?CHACC)>CIEFFHC.HB;AE@G@GEF-CCC8FA@*9@DCBB$F?>??BHD@;F8EDFCE2H:EBFEF5F3DI2EHG@;E>E.F5EB?<&BHFG0@>CD.J;D,;>H8HDG/JJ0@0@D<+ACG0DCEAD@EF;>>ADGA8E+:DG<%47AD?@*=D24B<$BFD='G?J=C'>?AG>IIFI9@C+@?:<:E4HDC>B34B@>9E95F<9$AGHECB,D>HHF6J>>H*3;F5F=EH@E<4EF@04C8FG':@IACF3?<@->=1@9DFFG68?CA8E798?92F@(2-4$=AB26*27=@ED==AAAJ9IGFGC@GGD;A8CIJF-E5(0)&'A@?B?.@BD?#156GFBG:FCGG8;E>F4B< @rCer/2380/25_1623_CCS ATGGGGGGCAGATTGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTATGAGCCCGAAGTTGTGGCAGTGCACCCCGGCGGGGACACGGTGGCGGTTGGGGGTGCGGATGGTAACGTCCGCCTGTACTCCATCCTGGGCACCACACTGAAGGATGAGGGCAAGCTCCTGGAGGCGAAGGGCCCCGTGACCGATGTGGCGTACTCCCACGATGGCGCCTTCCTCGCGGTGTGTGACGCCAGCAAGGTGGTCACAGTGTTCAGCGTTGCTGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGCCTGGTCCCCAGACAATGAACACTTTGCCTCCGGTGGCATGGACATGATGGTGTATGTTTGGACCTTGAGTGATCCGGAAACCAGAGTCAAGATCCAAGATGCACACCGGCTGCACCATGTCAGCAGCCTGGCCTGGCTGGACGAGCACACACTGGTCACAACCTCCCATGACGCCTCTGTCAAGGAGTGGACAATCACCTACTGAGGAGCCCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGCGTTTAACTGCAGCGGAACATGTCCTTTCTCTATTTCTGTGACGCGCCCCCATGCCCCCGCCCCACTGCAAGAGGCAGGAGGGCCCCGTCATGACCCTCGTCTCTGCGGGTGTCTGTACACGTTCTTCTGAAAGCTTTAGACAGGAACAGTTTGCACATGAAAAATAAAGCAAGCACCTAAACAATGTGTGGAGCGTAACTAAAACCCACAGCCCAACCAAACCTTGAGAATGCGGAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGTGGCTCTCACTGTCTGTCAGGGGAGGTTGTACAGGTGAGTGAGCCGGGGAGCTCACGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAAAAGAGGGAATATGCATTGCAGTTCAGCAAAGCCGGAATTCTGTGTTGAGCAGATGTCTGTCTCTCCCTAGTGTGTGACTCACACTGTGTGGCTGCCTTCAGAGTGCCACCTCCTGATCAGATGGGGGACACAACCCCTGGATATGTTTCCTTGTCAGATTTTGTGCTTGATTTTAAGAATGGAATTGTGGGTTGTTTTGGTTTCTTTTTTTTTTTTTTTTTTTTTTAATGTATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGTGTTGACGGCACCATGTCCAGGTTTTTTAGAACCCTTGTTAGCCAGACCGAGGTGTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCTCTCCTGCTCTCAGGAGCAAAGGTTAATTTAAGGACAAAGATGAAGTCACTGTAAACTAATCTGTCATCGTTTTTACCTTCCTTTTCTTTTTCAGTGCAGAAATTAAAAGTAAGTATAAAGCACCGTGATTGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCCCCTTGCACTTGTGAAAACACTGAGCGCTTTAAGAGATTAGCCTGAGAAATAATTAAATATCTTTTCTCT + ?,,@GFE@A?D?@CF@@CC@DFABE=C=>@AA7=?3.:96>C@;=?/;@<@???@>7=><;B=27@@?A=;:>58<<:>5?=CAACBACBC=@AC75@CCAC3@7@C>?C>@@BB>ABB;>C@BCB7@7B?49<=>53;B:8A::=7<8A<:CAB>?BA=8@99AC@C;<=>=-=A;=?9?/A=A>?A@ACB/?A@@9B?=;;@7A;:A8<6@B2>>/9=@8==C;>AA@BAC;=:>@05>BB>A1AC>CC>BA>C?C?<<69<1>CBA1BA;C?@8>9;>@>>=<6>CB>9;ABC=99CCCBC>;A;=B<85>4DBF8@>A=2>BFF9A>BBD=?;F=EBADDDDA5CBFF@?CFGG;CBFD;C?CFDCAFE@CE@G3@BC=AABDGDF>07.=?>2.67AECEB@;C>CGD8BBCB>AAA;BB>-;A6@FA?>F:AFFEF@?:C6>CDDDFD$57BFBCEFDEFADB>G?AGE@A:E?=E5BC>CDGC.BDFBBBB5DED>ECEAFE@@>-CAC3A@;9BCD?EAFFBE2E>>E<@+BCBC;G@A?:F98?<2AAE@@A:?==BCD3@CECEEBEFGFC:A@B8>E:FGF=GCACDEEDEDAAD?DF@@EEBDCD6DC@.?D>:@1==9@>ACE6EF@DDBBEDAE;BB>EEAGFF;;A3BB@6DC?6A>@><8E9D2>FC9B6@B=ED>@B7C;B?B5EDC;F+>6EEGECDEEE=CA@7ADD?E??EFD:ADAEDABE8AEEDCBGDDC?@EFCD5EC;DDEECDAEG@?F:7@DF@BC;<7=1?E?EFC?B@>9=CDEGADC@EBCF;FFED:CDCFD<;GG:;A73?E@D?D=E57@GE@D@*EFEAG8@:@&8;@?BBBBAAACBBBEED@DECCE>>=>FAGBAF?E9D??ECFA>D>E9FCC<>A:;BGCECC87<@C7=B>*6@;9C:@?=:D?BDGF@C;EECDE@?CDE=84=>A5DFFBCBAFGF?ECF?@D6C5>BCDCGD?D<:C8DDCD1:F8E<>)BEE>;DFGG?:EFEGE85DD>F*BFEEF7DEFFE8CBD;C=@C@BAFFABEE/CDEEAEFABC:BEBE;CA?>F?CG<>GGEE(DFFEGDEG@;AD2>):;@:BFF==EGFE4CC:EEBCEBE>DDEGC:B;FBEBC:F?GED?::/=EABBC@ @rCer/2381/1877_61_CCS GGAGTACATGGGGACTGTGCACCGACGTCGGCGCGGCTGCACCGCCGCGTCCGCCGCCCGCCAGCATGGCCACCACCGCACCTGCACCCGCTTCACCGACGACTACCAGCTCTTCGAGGAGCTTAGGCAAGGGTGCTTTCTCTGTGGTCCGCAGGTGTGTGAGAAAACCTCCACGCAGGAGTATGCAGCAAAAATCATCCAATACCAAGAAGTTGTCTGCCCGGGATCACCAGAAACTAGAACGTGAGGCCGAATATGTCGACTTCTGAAACATCCAAACATCGTGCGCCTCCATGACAGTATTTCTGAAGAAGGGTTCACTACCTCGTGTTTGACCTTGTTACCGGCGGGGAGCTGTTGAAGACATTGTGCCCAGGAGTACTACAGTGAAGCAGATGCCAGCCACTGTATACATCAGATTCTGGAGAGTGTTAAACCACATTCCACCAGCATGACATCGCCACAGGGACTGAAGCCTGAGAACTTGCTGCTGGCGAGTAAATGCAAGGGTGCCGCTGTCAAGCTGGCTGATTTGGCCTAGCATCGAAGTACAGGGAGAGCAGCAGGCTTGGTTTGGTTTTGCTGGAACCCAGGTTACTTGTCCCCTGAGGTCTTGAGGAAAGATCCCTATGGAAAAACCTGTGGATATCTGGGCCTGCGGGGTATCCTGTATATCCTCCTGGTGGGCTATCCTCCCTTCTGGGATGAGGCACAGCACAGCGTATCAGCAGATCAAGGCTGGAGCCTATGATTTCCCATCACCAGAATGGACACGGTAACTCCTGAAGCCAAGAACTTGATCAACCAGATGCTGACCATAAACCCAGCAAAGCGCATCACGGCTGACCAGGCTCTCAAGCACCCGTGGGTCTGTCAACGATCCACGGTGGCATCCATGATGCATCGTCAGGAGACTGTGGAGTGTTTGCGCAAGTTCAACGCCCGGAGAAAACTGAAGGGTGCCATCCTCACAACCATGCTTGTCTCCAGGAACTTCTCAGCTGCCAAAAGCCTATTGAACAAGAAGTCGGATGGCGGTGTCAAGCCACAGAGCAACAACAAAAACAGTCTCGTAAGCCCAGCCCAAGAGCCCGCGCCCTGCAGACGGCCATGGAGCCACAAACCACTGTGGTAAACAACGCTACAGATGGGATCAAGGGCTCCACAGAGAGCTGCAACACCACCACAGAAGATGAGGACCTCAAAGTGAGAAAACAGGAGATCATTAAGATCTACAGAACAGCTGATTGAAGCATCAACAATGGGACTTTGAGGCCTACACGAAGATTTGTGATCCAGGCCTCACTTCCTTTGAGCCTGAGGCCCTTGGTAACCTCGTGGGAGGGGATGGATTTCCATAAGTTTTACTTTGAGAATCTCCTGTCCAAGAACAGCAAGCCTATCCATACCACCATCCTAAACCACAACGTCCACGTGATTGGGGAGGACGCAGCGTGCATCGCCTACATCCGCCTCACCCAGTACATCGACGGCAGGGTCGGCCTCGCACCAGCCAGTCAGAAGAGACCCGGGTCTGGCACCGTCGGGATGGCAAGTGGCTCAATGTCCACTATCACTGCTCAGGGGCCTCTGCCGCACCGCTGCAGTGAGCTCAGCCACAGGGGCATTAGGAGATTCCAGCCAGAGGTCGAACCTTCGCAGCCAGTGGCTCTGGAGGCCTGAGTGACAGCGGCAGTCCTGTTTGTTTGAGGTTTAAAACAATTCAATTACAAAAGCGGCAGCAGCCAATGCACGCCCTGCATGCAGCCCTCCCGCCCGCCTTCGTGTCTGTCTCTGCTGTACCGAGGTGTTTTTT + 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@rCer/2382/0_1004_CCS TCGCGCAGAGCCTGGCTGGCCACACAGGAACCTGCCTGGGCCTGGCAGGCACAGTGGCCACACTGGTCTTGGCTGTAGCCGGGAACCTACTCATCATTGCTGCTTTCACGGCCTCCCTGCTTCGGGCCCCCGGTACATGCCCTCTGCTGCAGGGTGGCCCACTGGAGGGGGTACTCAGGCCAAACAACAGTGAAGCCCCATCCCTGACCCTGCCCTGGAGGGGGCAGAGGCCAGGCCCCCGTGCTGAGGAGGAGCCCAGAGTTGGGCCTAATCAGGTGGGGACACATCTCAGCTTGGAACCAACAGGGGCTGAGGAGAGAGGGCACAGGAGAGGGCACAGGAGAGGGCACAGGAGAGGAGGGGTGTCTAGGGGAAATGGCAGAGTGTGAGCGGGACTGTGAGGGGGCTCTTGATGGGAGTAGAGGAAGTGCTGAGGGTCTTGAGAGGGGAGATGCATGCGTGTCCAGGCTGAAGATGCCCCCACACTCTGTCAAGGCTGGGGCCAGGAGGTGTTGGGGTCCTTTCATCTGGCTCCATTTCTGGTGCTCCTGAAGTCTCTGCTCAGCACAGGGAAGAACTAACACGACTAACCTAGGCCTACCCCAAATGCTTCTTGCTAACCAGGCCGAGAGGCCACACACTTGCCCCCCATCCCCACAAACCAGGTAATGCCAGTTTGCCAGCAGCTATTTGCCTAGAGAGATGAGTCTGTCCTGGTCATAACTGTGTACTCAAGGTGTCCAGGCTTTTGGGGGTGGGCCTATCTGGGTGCATTGTGGATGGTTCAGTGGATTGAGGTGTGGGGAGGAGGGTCCTAGGCTAGAGGGGGGATCCCTAGTTAAGACTTTAGGAAGCCACCTTCAATGTTTTCTGGAACAAGGCAGGTACAAATAAAAAAATAAAACTTTGGAAAGCACTTTCTAGAACTGAAGAAGGTAAAACCTCCTCACCCCCATCCTCCTGACACCTCCCTCCCACACTCCATAAACTGGACAGATTCACAG 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S+(,,,'/&**0&(/-/.**&,()%*++$-/20,'-3(51-.-$.-/+.'-004+25%..*3210//0,3.6250,44+1+435646/4562.-,0466451446131+060140/6423-55,//.53560(5*+,0.-.1-4765+252.'11/626994428)#,.42-69:75533301,7065141-134)63411/441/3.6743)-/9745-/366/47-8:5;94:-8699572012442569576;5/669'.*95+)31.76817608<7,.6:/463:6:<+63>:7<<*2470><9?A;4657;<;817902174>7851==:?2:533+85677,21.4/+.244&2.9656./5356843+024038762014332:<57:/2:71,41/4774/:38;.:8584376,2-,--0))'02-566796834+25-//623'288226414;64125%*20,,/+0/0.478:9<6+;>96)/19.<;2'=5/01(54648-766<;;/>4:;3>>9618==73:/28,34178-8::074;/=7=9<4;<=-;55,9;:>8'3<:188<566:4(55/,4+2/3+2+534-3<239,689?<3405,1-+04;6:;91;9<<=:97:8970?<:>2&3&76456)9;5595958=783=<;+9<7.;84426<=+6:?<976263256506614;=606:4;8155/$/#/87176/631>3171+24537429;6%53213255403-&./06526473607*55106.786=1/674>>95;67;15:::==91;8:2:5569;7798':;945:=9==:>9=:5?==6;=<74;5:/7:28<==<*:256;9=;:8339=-;35=88;;7<49:=1?===7;;188<0/8;2;-8;<=>97:;8=/17?>852526:352'65//2,112,,+.31883056524539<;:0-<662>;565866;83'3263-7375-1(2352-( @rCer/2384/2052_61_CCS ATGGGGCTGTGGCCGGAGGCCGATCAGTGTTCTAGGACAGATCAGACATTTTGTAATGATGCCTGAAATAAACACTGACCACCTCGACAAGCAACAGGTTCAACTCCTGGCAGAGATGTGTATCCTTATTGACGAAAATGACAATAAAATTGGGGCTGAGACCAAAGAAGAATTGTCACCTGAATGAGAACATTGAGAAAGGATTATTGCATCGAGCTTTTAGTGTCTTTTTATTCAACACTGAAAATAAGCTTCTGCTACAAGCAAAGATCAGATGCTAAGATTACCTTTCCAGGTTGTTTTACTAATACTTGTTTGTAGTCATCCATTAAGTAATCCAGGCGAGCTTGAGGAAAATGACGCCCTTGGAGTGAGGCGAGCAGCACAGAGCGGCTGAAAGCTGAGCTAGGAATTCCCTTGGAAGAGGTTCCTCCAGAAGAAATTAATTATTTTGACACGAATTCACTACAAAGCTCAGTCGGACGGTATCTGGGTGAACATGAAATTTGATTTACATTTTGTTTGTGAGGAAGAATGTCACTCTGAATCCAGATCCCAATGAGATTAAAAGCTTTTGTTATGTGTCCAAGGAAGAACTAAAAGAACTTCTGAAAAAAGCAGCCAGTGGTGAAATTAAGATACAACGCCATGGTTTCAAATTATTGCAGAGACTTTTCTCTTTTAAATGGTGGGATAAACTTAAATCATTTGAATCAGTTTGTTGATCATGAGAAAATACACAGAATGTGAATATGCAGGTAAGTGATTACTGAAAATGTCTCTACTTAACAAACTTAGAATGACCTTTTTCAGTTTTAAATTTAGTTCTATCATTAATTGATCATTAAATTTAGTTTCTATCATAATTGATCATTAAATTTATTCTATCATTAATCATTAAATTTAGTTCTATCATTTAATACTATCATGAATGTGTTATATATCACTGATACTTTAAACTTGTGTGGAAAAAACTAACTTATAATTTTGTATCACATGCCCTGATATGTGTTCTGTTTCTAAGCAACATTTGTAAGGATTATTGTAAAATGAAGAGAGCAACTAAAACTTAATTTAACCTTTGCAGATAACATACTTACGGGAAATTTGAACAAATAAGTGAAACCCTGTGTGTTTAGTAAGCTGTGATAAACCATTTCTGGAGCACTCGCAGGCACTTGCTATTTGCCAGGTGCTTTATATATCATTAAATTTTTATCATAGTTTCAGAAAATGTGCAAAAGGAAACTATTGTCTCACTCCTTCAAAACAGTCCTAATTAACTTTCATATTAGCAGAGATTAAACTAGCAAGCAGGTTCAAGGGAAATTAAATGATATGGACCCTAATTTGTATCATTCTGAGTTGATTGTGTGGTTTATCATTCTGGAAATGTTGATACTTAAAGTCACCATTGCTTTTGATAAGTGATATTGATTAGGTTAAATCTTCTTTTAAATAGCATTTACTAGTTTAGCAAAGTCTGTGTTTTCAGAATTACAGTGGGCACAGAGGTGTTTCATAAAATAGGAATTGTGTCCCACTTGATAAGAGTTGGCTTAAATTTGATACTGTTGGACATTTGGGCTGGATGAAATCCTTGTGGTAGGGAGGGTTCCATGCTGTCATTATAGGGTGATGAGCAGCATCCCTGGACACACACTGGATGCTGTTTGCATCCCTTCTCCGTGACACCCACGTTATACCAGATGTTGCCAGATGCCCCTGGGGGGACAGCGTCAACCGCTGTCCTATAGAGTCAGGAAATGTTATAGGAGAAAAAAAATAACAACGACAAAGGCCAGTGTTCATGTTAAATAGATTGAGATTATGGAATGTGTATATTAATGTTAAAATTGTACCTTGATCAATGTACTTTTATAAACTTGCCATAGATATCTCAAATTTGAAATCTCAAGACAGCTTTATTATTATTAAATGCTGTATGATAATGAAGAAAAATAAAAATTTATTTCTTACAAAGTTAAATG 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@rCer/2385/25_1611_CCS ATGGGGGCCGAGGCACAGGCTCTGCTGCAGGAGCAGCGGCCCAAACCCGCTCCAGCGCCCGCCGCCGCCGCCAGCGACTCCCGTGTCGCGTGTGTCCCCCTGCGCACTGAGGAAGCCCACCAGCCCTCGCCAGCCCCGCGGAGCGTGCGATGGCCCAGCGTAAGAATGCCAAGGGTAGCGGCAACAGCAGCAGCAGCGGCTCCGGCAGCAGTAGCACGAGTGCGGGCAGCAGCGGGGGCAGCAGCAGCCCCGGGGCCCGGAGAGAGACAAAGCACGGAGGACACAAGAATGGGAGGAAAGGAGGACCCTCGGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGCCAAAGCAAAGGACTTCCGTTATAACTTATCAGAGGTGCTTCAAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGCCTGACCAAAGATGGCAGTAATGAAAATATTGATTCTCTTGAGGAAGTCCTTAATATTTTAGCAGAGGAAAGTTCAGATTGGTTTTATGGTTTCCTCTCATTTCTCTATGATATAATGACTCCCTTTGAAATGCTAGAAGAAGAAGAAGAAGAAAGCGAAACCGCAGATGGTGTTGATGGTACGTCACAGAATGAAGGGGTTCAGGAAAGACTTGTGTCATACTGGATTTACATAACCAGTAGCTTTGATTCAGGGACTGAAGTCATTGGCAAATGAACACCCGAAGCAGCCTCCTTTTTCTTTTCTTTCCTTTGCTTATGCAGGGCTTAATGTGCAGTGGGGCGGTTGTGATCTTACCGTGCAAGTCAACCATGTGATCTTGCCCAGTACAGCTACTAGCTAGTCCCTTGCTCGCTCAGCTCCCCCAACTTCTATTGAAGAAAATGGTACTCCTCATTCTTATAGTCAACTACAAAGTACAGAGAAAATGATGTTCTTGGTGGTATAATTGGTTTCTGTATCGTTTTGTTTCAACTCATGTATTCACTGAACTAAATTTGGACACTTACAGCAGATTGTGTTGTGGTTAACCCTTGATGCTTGTCTTTCTAACACACTATTAATTAAGATGATTCTAATGGATTTCATTATAAAAATATTTCTGGCATGATTTTTAAGTTAAATACTTCTCTGTTCTTTAACATGACTGATGTGTAAAATGATGGTTCTTTACTAAGCTGATATTTTTTATTGTAATTTGTTTAGGTTTGTGTCAGATAGATTCCTATAAATTTCTATGTAAAATTCTGTGTTAATGGTGCTTTTAAAATAATTTAAAAATAACCCCATGTTTTTGCCTTAGAGTAAGTTAACTTACTGTTTTCAGATAGTAGCATGACATATTTCTGTCTATGAAAGCAAAATTTATTTTCAATTTTATTTCCAAATATACATCCAGAGAAAGTAATTTGTATTTTTTTTTAAAGTAGGCATATTACACATGAGGGAATATGTGAATATGTATCTTAATGTTGTACATATTAAAATTATTCATCC 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@rCer/2386/1770_48_CCS GGAGCTGCAAAGCGCTGGAGGCAGCTGAGTGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACACAACTTCAGCGCAGGCGGAGGAAGCTCAACTACAAATGGAGCTCAGAAGGAGATCCGCGAGGCGCCCTGCCGCTGCGCGAGCGCTGCGCGAGAAGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGAGATGTCGGCTAAGGGCCGGACGGGCGCGCCATCTGCGACAGAACACGTTCGGGTTTCGGTTTGTTTCGTTCACTCTGTCTAGATGCAACTTTTGTTCCTCTCCCCCACACACCCCACTTCATGCTTCTCTTCTGCACCAGCCCCCGCCCTGTCTCGTGGTGAGTCGCTGACCACGCTTCCGCGGCGCGGCGAGAGCGGTTCCTCGTGCAGACACCAGGCGGCGAGGCTGGTCCCGGGGCCTGTGAGAGAGGTGGTGTGACCGTGGTAACACAGGCGGTGCGTGGATCGCGGTCCTTACACTGGCTGTCTGGTCAGCATGTGCAGTCAGGCAGGTCTCTGAGCGGCCCCTGGCCAACAGGCGGGTAGGGTACTGCTGTCTTTCCAAGGGAAGGGTCCCATGCGGGAGGGCACGGGGAGGGGGGGTGATGGTGCTGGGAGCCTGCTGTTAAGCGGGGCTGTTGAACTGGCAGGCAGGTGGTGGGGCTGCAGCTCCTTAATGTGGTTGCACAGGGTCCTCTGAGACACCTGGCTGAGTGGACACCTGGCCTTCTGGAAGCTGCAGTTGGCGGCCTGCCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCAGGGCCATGAGGCTGCGTGTCTAGAGGTTGTGGCAGCATGGACAGTCCCCACTCAGCAGTGCAAGATTCCAAAGAGCTCTGGCCAGGCGCCTAGGTGAGACAGCCCGCCCTCCCACAGGGCTTGCGGATGTCTTGAAAGACCCGGCCTAGAGCCTTTGGATGTGGCCCTCCTTGCCTCTGCCTGGTGGAAGTGGCAGCCACAGTCTCCGAGTTTTTGTGGACTGCTGCCACAGATCAGGTTGGAAGGCAGCGGTAAGGTTCACAAGCACCCCCACACCTTCCATCGGCACCAGAGGGGGTGTGGTCGAGGCTGACTCAGGCTCTCTGCCCACACTTCTGGCTGGGTTCTTCTCTCCCTGGATGCCCAGTGCTGCCTTGGAGGACGGTCATCTGGAGACGGGGTAGGGAGCTGTCTTGTACACTGCAGCATCCCCACTTCCCACAGAAGCCATCCAAAGCTGCTGCCTGCATTCGTAAAATGTAAGGGGCAGCTGAGTTCTCTTAGGACCAGAGCCAGGCCTCAGCTTCCTCCTGCGGGGCTGGCAGGCACTGCCAGCGTCTTCAGGCCAACCAGGACTATGGGAGGATCCTGACCCCTGCAGGCTCAGGGTCACAGGACCACTGCCCGTCTCCCTCTCCCCACCGAGACAGCCCAGAGGAGCAGCCAGCTGGGATGGGAACCCAAGCTGCCAATGTGCTTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGCTGGATTCTCCTCACGGTGGCACTCTCATAGCGAAAGCTAGTGTAATATGCACCCATCTATCACGTAGTAAGTGAACTTAAAAATTAAATCAAATGAACAATAAACCTGTGGTTTAAG 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@rCer/2387/0_1966_CCS GAACAGCCCTTGGTGAGCCGCCTGACCCTCTATGATATCGCGCACACACCCGGAGTGGCCGCAGATCTGAGCCACATCGAGACCAAAGCTGTTGTGAAAGGCTACCTCGACTGAACAGCTGCCTGACTGCCTAAAAGGCTGTGATGTGGTAGTTATTCCGGCCGGAGTCCCAGAAAACCAGGCATGACCCGGGACGACCTGTTAACACCAATGCCACGATTGTGGCCACCCTGGCTGCTGCCTGTGCTCAGCACTGCCAGAAGCCATGATCTGCATCATTGCCAATCCGGTTAACTCCACCATCCCCATCACAGCAGAAGTTTTCAAGAAGCACGGAGTATACAACCCCAGCAAGATCTTCGGCGTGACGACCCTGGACATCGTCAGAGCCAACACCTTTGTTGCAGAGCTGAAGGGTTTGGATCCAGCTCGAGTCAACGTCCCTGTCATTGGTGGCCATGCCGGGAAGACCATCATCCCCCTGATCTCTCAGTGCACCCCCAAGGTGGACTTTCCCCAGGACCAGCTGACGGCGCTCACTGGGCGGATCCAGGAGGCCGGCACGGAGGTGGTCAAGGCTAAAGCTGGAGCAGGCTCTGCCACCCTCTCCATGGCATATGCGGGCGCCCGCTTCGTCTTCTCCCTTGTGGATGCAATGAATGGAAAGGAAGGTGTTGTGGAATGTTCCTTCGTTAAGTCACAGGAAACGGAATGTACCTACTTCTCCACGCCACTGCTGCTTGGGAAAAAGGGCATCGAGAAGAACCTGGGCATTGGCCAAATCTCCTCTTTTGAGGAGAAGATGATCTCGGATGCCATTCCCGAGCTGAAGGCCTCCATCAAGAAGGGGGAAGATTTCGTGAAGACCCTGAAGTGAGCCGCCGTGACGGGCAGCCAGTTTCCTTAATTTATAAAGGCATCATGTCACTGCAAAGCTGTTGCAGATAACCTTTGTATTTTAATTTGCTTTGGTGATGATTACTGTATTAACATCATCATGCCTTCCAAATTGTGGGTGGCTCGATGGGCACATCAATAAAAGCCGTCCTTGATTTTATTTTTCAAGGTCCCTTCTGTCAGTGCTGTGCTTTCTTCCCTGTGAGAGCTGACTATAGCGTGTCTGCCACCTCTTCATTACTAATCAGAACTAGATGATGTTTAACTTAGACTGAAGCGTGACGCTTTCATCAGTAGCTTCAAGAAAGTCTAAAATGTTTAATTTGTGGAATTGGACACAGTATTCACAGGTTACCTGTACGTGCTCCTCCGTCCCTCCTGTTGGCACCCTTGCATCGCCCGGGCCTGATTCCTCTCGGGGGTGGTTCACCTCCACAGGGTCATAGTTCAGCGGTGAACGCCGGGCAGCCGTTTTCTGGCTAAGCAAAACAGCACCTTTCTCTTTGAGCTTCCTCTGCTGACCTCTGTCCCCCTTTGGATTTCATCTTCTGACCGAACCCTGATGTTCAAGTGGCAGAGACAGCTGATGGCCAGAGCTGTGGGGACACCAGGGTGGGGGTGCGCGTGGACACCCCAAACCCCAGCTGCTGTGTCAAGGCTGAGGACGCCGTGCCACCATCAAAAGGGGGTTCCAGGTTTTCCATCAGTGGCCTAAAGAAGGGACTTCGTCTTACTGAGGAGTGGGGAATTAAAGAGATTTGACTCCCTTTAGTGTTGGGGGCAGTCCATTCCCCAGTCGCTGCGGCCTCTGAAGTGGAAACTGAAAGCTGCATACCTGGGAAGGAACTTTCTAGCAACAGGCAATGGCCTTCAGTGGAAGAGGGAGGGCTAGAGGTGTGCCCAATACTTGGATGTTCATCTGCCCACAACAGCTTTTTTTTTTTCAAAAAAGCTAAAGCTGAAATGGATTTTATCATAAAGGATCACATTGTTTTCTTCTACAAGTAATACATATTCATTGTGTAAAACCCAAAAAGCAGCTAAAAAATAAAGCGGAAAGGAACCACTG 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S&-')/(0/*-'/01-.)1+(,//1&(*1**+-00.'(*010.,(.-(,..,,'(,,+&,1.+-)-010'-.,.++,.//,0.2$.(**,1*',&%)**.11*#&'+($($'%',)'),0+**(,+*+-,-2+))416501100/4/-5/-2//0)-+4/2-0&'(,/),,)#&154.,*-10,.01565)/33,3*-/64%3&61827-0'-44223017=88>8>4,3/6/907972,)78==;790()$5322%-593;318.8;,6=9<246<=6;=/95>7#0-804&36<-975784-78=<:;9>:=:;87=6.638;59-496,694=5:92,459=+:=<89526;-12:>7+54<<;6502284679237,333479/73:9::54:)7768:;=5;6547818/68/63+<152;9::-6=7+1;2;3;:293995.307/606=67010/7%754:98&45:348'47873;<9887:>9=4798'3..38=25640)62+4*551--2788/869699:<:0013756+675254,375%5778.73963:7=1.40,47402,5:8.55:496989::0985;>:351596==93=6307:947)211>=:42183736177=9725313..851254773;86:?>3<387.<';5=98*5=;24)9:916:?;?148>>=5=.7:7==4:83&+$03;:7)1,2626777096*487696933.11*9765137/29>928=69866.50/.606(87<5951:42566/-8<,99-8>85<3=9850=::6.5:>572+:;5,;.96=7955//4.4(*'7.(8;28:4=:9:3:><72+6=:==-74,6465=9;0<4:7=89872918/537123387,1=>6:07;<720<61/;55=(/213:3141<>>88+3599>2.9<8119;7342,03683.-2577.64/-+;==1<9>6:*830,/:8<3+228951:9043721&/0778361*41:51-8*.76;>:7888.1105144.)4./584;.,4214273..+,1'/5-2/354-34,/255/162+,4,$10;94762+./1/874226+/234230467987488368*4435-0$5633/&4&'6+3.*/.7-2-11701/4)5:945)33*00038.301+3/24+.$5955241',3556::998;87.9;3://13821.43790,55:/92:86,5)01&49451443/:4+51/..-6(3142-(655750263652839557/,*)/4'5/*//148829.3*358869-43715:59214559.00:(184-,))/15832.07)53533752$3-3/'/34(47+2413.)4-.125%7/120%160'306.4.3856885%.',/5302((*13)2.77478470/85+768362/0-+25.484,0..353*4612/0*/3$+(,)-5:343+%067704544)1-80,5136)655)2.,2)6/:15:(54-.-14)1(./8)47-/876627'25(655,04/6940'+08-4-42*241.%131/2301*31279475/3.//416+645439525.601++//*1/(52069573:1204'7--&(-620:8-4605/0/$5846869:6;9:934++187*565440/..-3-08/:462265'2*125*0549;6:791--86465(3204.246;8=451+98884=;.?@9=>;512060%+87-895776-92;4/3.200.,+/2$20+'**362+*5251035,22//652+35044-154),0+552/-0564+&-01142.354.36)/%,3,005250( @rCer/2390/0_1620_CCS ATCGACAGAGACCCACCTATTTTGGCCCGTGCTGAACTACCTGAGACATGGCAAACTGGTGATTAACAAAGACTCGCGGAGGAAGGCGGACTTCTCCGTGAGCAGCTCTGGAGAAACGTACTGCGCTGTTCCCACGAATGAGTTGGCCTGGCTGCAGAGGAGAGAGAAGGTCACGCTCGGACTCACGATCTGTGACAATCCAGGCTGCGAGGTGGGTGTCGCACATGGCGGACCATGCACCCCAGGAGCCAGACTTGTCCAGGCCACACCGGGCTGGCTCACGGCTCACCTGCTCAAAGACGCCTGCCTGACATCTGGACACTGGCACCCTCCACCTGGCGTTCCCACCCGACACGCGCCTGGAGAGCGAGGTGCACACAAACGTCCAGTGCATTCTGCCGGTGGCACCGCTCAACGGAGGGCATGAGGACACGGTCCTGGCTGGCTCACTGCAGGACCTGGGTATCCAAACGTGCCAGGTACACAAACAGTTGCAGGCAGAAACAACCTCCTTTCCATCACAAACAGCTTGGGAGCTGAGGCGCTACAAAGGGAACAAGACTCAGGCCTCCAGCCCAAGGGCCTTCCTCTACAGAGGGCTGTGACAGAGCAGAGCCACAGCACGAGCTGGCCCGGGCCACCACGCAGCTGCTGTCCACACCGGCCCTGCCTGGGCGGTTCTGAGTTGTCCCTTCCACCTGCCCTCCTCCGGCCAGGCTGAGAGAACCTCACAGCCTCTGCTGCGGGGACCCGTTCCCTTCAGTGAATGACTTTTTTGCGGACTTCATGACTGCCCAGGTGCGGGGCTCACGCCTGCAGTCCCACTGCTTTGGGAGGCCAAGGCAGGAGGACTGCTCTAGCCAGGAGCTTGAGACCAGCCTGAACAACATAGTGAGACTCCGTGTCTAGAAAGAATTTCAGGAATTAGCCAGGCATGGTGGTGCACCTCTAGTCTCAGCTACTTGGGAGGCTGAGAAAGGAGGATCGCTTGAGCCCAGGAAGTTGAGGGTGCGGTCAGCCACAATTGCGCCACTGTACTCTAGCCTAGGCAATAGAGCCAGACCCTGTCTCAAAAAATAAACAAAAAACAAAGACTTCATGGCTGCATGTGCATCCTGCCAGGACCTCAGTGATCCTGCCAAGAAACCAAGGACATCCGCAAACACGCACTCGCCCCGCTGGCCTAGAGGAAAGCAAACCAAACCAAGAGCCAAAACAACGAAGCCATTCAGCCCTGCAATGAATCAAAGAAATGCAAATTAGAACACCACAGCCTATCACATTGGCAAAGGGAAAAAGAATAAAAATACATAGCGCTGGCAGGGATCTGAGGGGACAGACGCCGCGCTACGGGTGGGGCTGTAAAATGGCATCGCTTCTGGGGCAATTTTCCAATGAGCGTCAGAAGTCACAAAGATGTTTGCCTCCCTGACCCTGCAGTTCCCTCTCCATGCCGGATCTGTCCTTCAGGGTCCGGTGTGGCACGGTGACGAGGGCTGCGACTACCGGCAGGACGGGATGCCACTCGCTCCATCTACCTATTCAGTGTTTCTGTTCTTTACTATCATCGAGCGTTGCTTTTGTGACTTGTATTTTTTTTAAATGCCATCATTAAAAAGT + S;=B>?;<7>7#3<:(:8<5><:(A6@D@6E>AE&?69=7@@>>?>97A:D?1EA4@=?:EC@C=G?=EGD;$6FB>,?=+:AE(?C3BB:BG=C2E;?AF;@ACEB=:;AB24GGAF@EEFIED=DDD,=3@DF74$E;7DD>E:FHI=F=;>EF<@F=<>9?A?=EI*GC>DJGI;IJ=FHCHIKGKIE><'DG4FKDE7KI4JJEGGGDE>GKI*ID-KI9KGGBCI%GHJFFKB>DHBKGH3JKJ:JA2E(I480=>-KIDJ7I?IKIE3K0:>:*DG7HG9*FB<59D;3E8.;69GID9?HEF?I8CKGE>GBKJDB2EJ?:JFHF/E@@E%C7IE?JCH&C=8DCKCC5K@KJHI8KE4:CBD?J1HJHIIA:K0IK?<>EHC1HCC?BAF,JH*GI=KB%?C@5HIB4K7IHAIE?%E34F&>B&?4E.DEG2C+?,%JK&3C@JFH?FHI:GJJHKF;F?6==HBBCJJ>JBIH4E2%$6>KI?KJF;IHG.IFAHIKJ1HDH2KJ23A9-B4JCIA5KEBE4=:93F8JICIKKG*KEDGJDB9E1HKKJCKKHIK7KIAJJIAEJBJFIB80KKJJJJI@KFHGKHGAHHHEKCJJ>>FGHH&HGEFJJIJG8D;BDHGI+JJJJGGJDHI,KF>.H=K>K6KKJ2JI=KJKJJIGKKB+ABJ2KJHJ>IHKJKGJ@FJK3ECFIDKEJKDJJJKEIKAEKJJ:BHHKJHKKHHK4KKKF7KCKEKAB>KK*IAC>*HG3KIDDI9E@ACKJJJFJJHIHGIDK%=;GBHIEJIDCKKCKK?KKJBJH+KJEHAJIGDJ>KI@JIIAKKKIKHJHJKCCKJJKKJKJKKCK?JJJICGII7CHGKHJ3DDDFFHKEGAKBDI6KJIDJJJK4KKKJJJ?KIG2EFJJHF.K@,6I@IHFJ?KJ>G@CDGFE>?H>FII5IC8H5';9/IHDJG>KC(8&C<>A9G@>B<=DJE5HH8>??DJIAI7*?GA8AF@CEHEIJ>JAJHCKG*KG$AGKKH@IG-IKEFEDIGJJKJIKH9KKK'KKKGKKK?5KKKJKHFJJDBKHE@HJDJ4KKC/KKKKJKG-KJKHCKJCJKKJJKJJ%KIKIAJ;KJKD?AKHBJ8A?JKJJFG=FDJG9IKKJJJEKKKHKJ)KJGHKFJJGEKKKJK.KKKKJHKKJI4KIKKKKKKJ;K>KKJIKKK:KIK>JJDJJDK1KKJKKKK;KKJKKJJJHF>-K4KJBHKKH2KKKKF;K88?,;8602:9=9433,:81938::7369.%/15+900881/::660*)45/077970/6/320257:540/00.196465.48.2+408341-4&/35-6258445377/'329646;9:67671.+130,398505567'35334/587-.$412+0-8302-5=6<5'2437462(+7;43:85624>:303:89/>092,562:8326;59>3?/:/6077829>2/916%40.89.=2.722-4.9-7098>5>7;;967(364=9<838795;6<<=;=486+2/531:28:79?27<17-5187+7216<<'31395<697><=25<:;<*1=:6=856;75;=86:839496;<+96,1/::3:;7(1,'/23696:059(43466831/5.2:/0*+38*1518%6368:617798(43548<&'0+6=024<4082=*7:(4'*.;6/232.3/2/*.2&02682=<401389796*2233.3,)02.+,31511$-7223755(0444510'.5*)5;=10&1'/7;7=84222278:>9/86:;3<84-7'38(544;91/9831:7;8>;<59124<;68784.)76486.7:59-'330856.,0&/193738<3%-02<:288).7633:6('.4<4(36-.2593/60,5.47=,9356:4<.23683.7149=?<87;8=2734829-'742784:94175<<9092;:798)7>><45+9:9>5)+-46933044/:?596,7;86473<745/828127:::664=%446$,,6<:)9+>98-8757270&;:2;2:1526:9'//-,)6857/,%2;49?98:7*,09%20;05076401/-%2:69<69376025?8<:18:8*2653.8093:+35<#08=97731901',11;5275:84222:98:03/4:99>9>5-+8813?$376:3956;:2=8368586,96788358:&873%-2;608;:-6.68:1:,<:;6426070272:327987=672335651)0+.0-35-/64.66/24<3=8?;7599-::21:>835/9;79867=*5:2010.497.266<9()%3678./35-1)03';48;16980200%0/+*+0'.+41433,0'''+082683298-)79+65.871;8;:54:5-03<+7616=66589918=87$60;79:296<*%#-,+,185462994.2::844;885,(0>372=88:;)=.1-91707>>=':4588/96:.92,6/57;7186)/0270662%4-74&7,;88.63$745301;8?>2<=?5;9(<8>*61137357>1=252?>9?=7;98 @rCer/2394/0_1792_CCS GGCTGTCCGCGCCGCCGCTGCGGGGCCATGATCCGGAACGGGCGCGGGGCTGCAGGCGGCGCAGAGCAGCCGGGCCCGGGGGGCAGGCGCGCCGTGAGGGTGTGGTGCGACGGCTGCTATGACATGGTGCATTACGGCCACTCTAACCAGCTGCGCCAGGCACGGGCCATGGGCGACTACCTCATCGTAGGCGTGCACACTGATGAGGAGATCGCCAAGCACAAGGGCCCCCAGTGTTCACTCAGGAGGAGAGATACAAGATGGTGCAGGCCATCAAATGGGTGGACGAGGTGGTGCCCGCAGCCCCTTACGTCACTACGCTAGAGACCCTGGACAAATACAACTGTGACTTCTGTGTTCACGGCAATGACATCACCCTGACTGTAGACGGCCGGGACACCTATGAGGAGGTAAAGCAGGCCGGGAGGTACAGAGAGTGCAAGCGCACACAAGGGGTGTCCACCACAGACCTCGTGGGCCGCATGCTGCTGGTGACCAAAGCCCACCACAGCAGCCAGGAGATGTCTTCTGAGTACCGGGAGTACGCGGACAGCTTTGGCAAGTGCCCTGGTGGGCGGAACCCCTGGACCGGGGTATCCCAGTTCCTGCAGACATCTCAGAAGATCATCCAGTTTGCTTCTGGGAAGGAGCCCCAGCCAGGGGAGACGGTCATCTATGTGGCTGGCGCCTTCGACCTGTTCCACATCGGGCATGTGGACTTCCTGGAGAAGGTGCACAGGCTGGCAGACAGGCCCTATATCATCGCGGGCTTACACTTTGACCAGGAGGTCAATCGCTACAAGGGGAAGAACTACCCCATCATGAATCTGCATGAGCGCACCCTGAGCGTGCTGGCCTGCCGGTACGTGTCCGAAGTGGTGATTGGGGCCCCGTACGCAGTCACAGCAGAGCTCCTGAGTCACTTCAAGGTGGACCTGGTGTGTCACGGCAAGACGGAAATTATCCCGGACAGGGACGGCTCCGACCCATACCAGGAACCCAAGAGAAGGGGCATCTTCCGGCAGATTGACAGTGGCAGCAACCTCACCACGGACCTCATCGTGCAGCGGATCATCACCAACAGGTTGGAGTATGAGGCACGAAATCAGAAGAAAGAAGCCAAGGAGCTGGCCTTCCTGGAGGCCGCCAGGCGGCAGGCGGCGCAGCCCCTGGGGGAGTGCGATGGCGACTTCTGACCTGGCGGAGGCCCCAGCCGGCCCTCCCCCTGCTCTGCTTCTGCACCTTCTGCATTTGGACATAGGACTCTGCAGGGCCGCCCTCTCTAACTGGCCTGGCTCTGGAAGGGCTGGTGACGACTCTGCCTCCTGCCTGCCTTCGAGGTGCCTGGTTTGCAGCAGACTCTCCACCCTTTCCAGCGAAGCTGCTCAGAGAGGGCGTCCAGCACAGTGGAGAGGCCGGCAGTGAGACGGGCAGACGGCACCTGCAGCCCGAAATGCAGCACTCCTGCGTGCGCCCCCACCTGGTCCCCGGATGTCCCCACCACCTGGACAGAGGCCACACTGACTGCCCACCCAGCTGTGGCGGGAGGTGCAGAGCGGAGGGCTTTAGGGAGCAGCGACTGCGGTCACCCCTTTAGTTCTCTGGGTGCAGACCACAGCACCTCCCACTTGGCATCCCCCAACACGGTGTCCTGCCACCCGGCGCCGGCTCCAGGAAAACACGCTTGCCTTCATTCCGGCAGCTTCGCCGCTCTCCTTATGGACTCTGTTCTGTTTGTACGTGGCTGATGTAAATCTCTTTGGTACAACTGAATAAAGCCTGGTGGCACTGC + KKKKKKJKKKKKKKJKJKKKK)KKKGKKKKKKKKFKKKKDKJKKK0KKKKKKKKKKKIKKKJJKKKKKKJKDKKFKK0KKKKKKKIKKKKKFKKKKKKKKKKKJKKKKKKKKKKKKKKKGKKKKKKKIKKKIKKKKKKKKKKKKHK>KKKKKKKKKKKKKKKKFKKJKKKKKKKKKKKKKKKKKKKKKKKKKKIJKFKKKKKJKKKKKKKKJKKKKIKKHJKHK$KK,KKKKKKKKKKKKKJKKKKKKKKCKKJJJKBKKKK?KKJKKHKJKKKKKKKKJKKKKKKKKKKKKKKKKJKKKKKK>KKKKKKKKKHKKJIKKKKKKKJJ2KKKKKKGKKKKKKJKKKKKJKKKKKKKKKKKKKJEKK@KKKKKKKKHIKIKKKKKKKJKKKKKKKHKKKKKEKKHKKKKKKKKKJKKHKKKKHK=KKKKKKKKKKKKKKKKKJKKKKKKKKKKK4KKKJKKIKKJKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKJKKKEKKKKKKKKKKKKKKKKKKKKKKKKIKJFKKKKKEKKKKKKKKKKKJKKKKKKIKKKKKKKKKKKKKKKKKHKKKKKKKHKKKIKKK@K=KKKJIJKHJKKHKJKKKKKKKKEKKKKJKKKKKKKKKKKKGKKKKKKGKK%KKJKIKKKKKKKKKKKKKKKKKFKKJKKKK @rCer/2395/669_64_CCS GTCCAGATGGTAGAAAACAAGGGATGGATTGGCATGGCTTTTATTTTGTTTTTTTTGGTTTTGTTTTTTTGGTTTTTTTTTTGGCTTGGATCAGGATTTAAAATACTGGAACGGGTGAAGGTTGAGCAGCCAGTCGCGGTTGTGAGCGGCATCCCCCAAGGTTCTACAATTGTTGGCCGGGACTGATTTGTACGATTGTTCTTTTTTTTTAATTAACGTCATTTCAATATTGAGATTCGCATTGTGTACATGAAGTCCCTTTGCCCTCCTAAAATCGCCACCCCTACTTCTCTCTAAGTAGAGAATGGCTCCCGTCCTCTCCCGAGTCCATCAAAGGGGAGGGTGATAGCACTTGTTGCTTTCGTAGTAATAATATGTAAATGCAAAATTATATTTAATCTTCTGCCTGTAATATCTTTTTTATTTTGTTTTATTTTGAATATATGAGCCTTTTTCATGCCCCCTACTTTTTGTCCCCCAATCTTGAGTTGATGTTCTGAAGGGCTTTTTGGTCTCGCCTGGGACTGTGGTGGTTAGATGGCAGCCAGGGCTTACCTGTACACTGGACTTGATGACAGTTGAATTAAAAGTGTACACCTTAAATT + )%)*)(($#%%*,-'&*.)"(##,+)$#.(-'+#-.).+#+*,($%#*)#&'(*))(%('+*,+%'#$&$)))#)(&&&%$%)'+)#*$$,-*+%.*'("**-#-.*+*.)+-($--%#,&%&*,".-/$+-,+,**)".'-#+..--*.,.-*&($*)#,-)-.$..-"+-,#.%+-()%./.--.''.../(./*.-#-(##$%"%)*.++#'%#+..&-%+(.-,./$/.*/("#.-.,*/.",.*($,,-..+()"+*.(,+-,..-),-"$/*$.-+*+$../)..-),.--.""--.-#.,&&#+,)./--...*),/-#/*-.",$#+-)$&.$,*.,+.%/,.$.$"+#.$+&+...").,.$/-/-/.."+-//+-$%*-(#"$+'&.,.&-*.#/)..$-/-.-"-#'%#)(,&#'#-,&)*#(&)&.-+/.$../-.).-$)&(-.//*,)(*)"-,''$)',+%''*++$.$%--"#"...&#,//..),*##('+)$.+-..-(*(*.,&.$&.--##.%-#'.-"))#..*-+'*&-.&.-*//.-..//#,.-.$..#/(.*./(..,#-+),%-/.%.*,../+-('+# @rCer/2397/25_1652_CCS ATGGGGAGCAGCCCGGCGGCAGTCTTGATTCTCTTTTGGCCAGCAGTTTTTTAGGTCCATCAGTACTGCACTGCAAGAATGGCAGATTTTGGGAATCTCTGCTGGCCAGTTTGTGGCAGTGGTCTGGGATAAGTCATCCCCAGTGGAGGCTCTGAAAGGTCTGGTGGATAAGCTTCAAGTGTTAACTGGCAATGAAGGGCCCATGTGTCTGTGGAAAACATCAACCAGCTGTTGCAGTCTGCCCACAAAGAATCCAGCTTTGACATTATTTTGTCGGGTTTAGTCCCGGGAAGCACCACTCTGCACAGTGCTGAGATTTTGGCTGAAATCGCCCGGATCCTTCGGCCTGGTGGATGTCTTTTTCTGAAAGAGCCAGTAGAGGACAGCTGTAGATACAATAGCAAAGTGAAGACAGATCTAAGCTGTGTTCAGCCCTGACTCTTCTGGTCTTGTGGAAGTGAAAGAGCTGCAGCGGGAGCCCCTAACCCCTGAGGAGTACAGTCTGTTCGAGAATACCTTGGTCATGAAAGTGACCATCTGCTGTTTGTTCAGATCACAGGCAAAAAACCAAACTTTGAAGTGGGGTTCTTCTAGTCAGCTTAAGCTTTCCATCACCAGAAGTCTTCTCCTTCAGTGAAGCCTGCTGTGGACCCTGCTGCTGCCAAGCCTGTGGACCCTCTCAGCCAACGATATGGAGGACGACAGCATGGATCTCATTGACTCAGATGAGCTGCTGGATCCAGAGACTTGAAGAAGCCAGATCCGGCTTCCCTGCGGGCTGCTTCTTGTGGAGAAGGGAAAAAGAGGAAGGCCTGTAAGAACTGCACCTGTGGCCTTGCTGAAGAACTGGAAAAAGAGAAGTCGAGGGGAACAGATGAGCTCCAACCTTAAGTCGGCTTGTGGAAACTGCTACCTGGGCGATGCCTCCGCTGTGCCAGCTGCCCTACCTTGGGATGCCAGCCTTCAAACCTGGGGAAAAGGTGCTTCTGAGTTGATAGCAATCTTCATGATGCCTAGGAGGGACCTGACATGGGACCCATCTGCTCCTCCAGCCAACTCCTGTCCCTCACATCCCACACGGTGGCTCCTCCCACCTCCTCTGGATTTGTTCACTCTGAGATCCATTTGCAGAGTGGGTGCTTAGATAGAGTGAAGCTGGCTGGGGGGCGCAGTGGTGTGTAGTGCTGCTGTGTATCAAAAGACCCAAGGTATTATGGGGCCGGTTACTCAGAATGGGATGGGTTTCTTCACCTCATGTTAAGAGAAGGGAGTGTGTCCTGAAGAAGCCCTTCTTCTGATGTTAAAATGCTGACCAGAACACTCATGAGCCCAGGCATCCTGGAGCATTAACACTCTGTGACGAGCTCCAGACCCCTGCCCTGAGTCTCATCTCAGCAATGCTGCCACCTGCTTGTCTTTCAGAGTTTTTAGTTTACTCCATTCTTTGTGACATGAGTTAAGTGTCTCAACAACTCCTCAGGGCACCAGAGGACTCACTCACTGGTTGCTGTGATGATATCCAGTGTCCTCTGCCCCTTCCACCCCCAACCACATTTTACTGTAGCTTGTATCTGTGTCCTGTTGTCATTTCTGTTAACCTTCAGGTATTAAACTTGCTGCATATCTT + +++.-+%''#+&''",)')$*+,-(-(*&,,*-*,-,(+(,$)-+*$,+**)'&-*-.+-)-(+')'(+--')-(--*--+.--++)&',*,-$+,,*,&--,))$((,(,)++',,(()**&%&&('&)&&(-))*#)*''(&'+('*'*)*))++*.--)+-)(-(*,-)*&'(((&+)$,+-**&(,+-&(*-$''#)&)&')&&**,+*,+*.-*(*'(*(+)#'+,'++,(,&+*''-,()&,,,-,(+,),+'-)(',(&+++,,(,+)(-,+,-(,-+-*)*-+--)($&)+(%()(&%*)'&'&'*&(&')'))&&#)+-)+-,,+(.++(+,,-'*'-,)-+-.+----*-,-,,()%(&&(++-(+()'-#$',)*,-)),''(#&(+&)--*-*))+',,--,&"((*&,,--(+'(*++((.-*',,-($)'(**)++.,((+,,,+-,-,+()),((%))(-())$(')+-.--+-*-,%'#)*$++,,(,---(,,'**(*(-*+*-+',)**,,+'&,(('(+*,--,#,++((,-+#+--*--.+#)''()''%%&%%+,+,*,&$*('&+&&+"$)&*-+)),.-.+(',-,,-,',+,$*%*,*%%*'+'-()(-,-+#()'()+,))',,,+,.-,,+(,--)-+-'#',-,),*+,,')*%)%,*,+(**))%&'#&+)'+*('+,'(*.),)-,)++-*'#*-,&*,-,,---,)*''&,,)$(),*,-*,(*,(&),*,+,-%,%'-&,-,%*)--+*-+#'&%(''$(*))+$)+(,,-,-,*)),),%+',(*-*&,&'-,)(,+*''-+-(,'&('$*%(('&&($)''&$%&$())''%"')(&(())*'(*,+)#*).')$%$'&)+(++(-'**+',)%()*,,(+*(++-*'$+))##'++(-(-+-*&,),%-,(+(,(,$)')''',,-+-+.,*--&(+&(&($**,(-&())++-&('#$(+-),,'++($.,-,,-./&)''*,*)+,,,0.-,110+110*0+,101.11++/&+-1+.+/+/**+,-0/011-0/+).)*%,'(011011,-+%)*-&0././()./1.2../2.01010-010./0+.,20/*,.--(*,*,.*+,((&,$+,,+)011-*/1-%)-/.-+,..0----))11-111+--))*&*,-/**(1../')+,//2,-01(-&,+)&+%%'/+,-*+%%,-)/0/1021',/)%+.11211.,+$*#)+,++.%//(.,-.0,(2100,-(/..21%-,*-/,0.)/../0..+0,.1-,+**'0/+-,,($,0'&.,&*-/--.2-*0/10)+2/0/1/,$*1.0/-*/*1.-2/0,'01000(1/-+&$+1,,.+/-..-0-/.,.1.)0-+2101()0,+&.0,0/).$'"%&'*&)++)+&**)*))+)+),+-*&)-+*.,,-,,''$((,*,,#')&))($$+*,+),*--.++)+-'))+,-*(*++,+---'%()---)(*(((#$++,*)(*)+(,&$%&,+,,+-)++)*'-,,+-,,+'')#&(*+(,+)(('*),-'**,-,&''&#%(().)'-.-*+.,)()%()('-,,-+-*++'((* @rCer/2398/1736_59_CCS ATGGGGACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAAATTGGAGGCACGATGAAGACGCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACAGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAACGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATTGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATTCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCT + 22469,.1213.50;;7;2/;;745-9;:7:7856643*971867/84:863)*,3-63658478459;?9/29;%>2?;5=73870*785(34::9:77+14-03+'(*+72&-5977:646..099-31586(9;24(.+5437568:-53,//.58771367'4).0/425445-9;:;6460&351)15201*6',//0244638.7/360;5694902577+8813:7.958733+32997:995565/747443*0933789*6648444.77./75/441.1768-3//25-9:9556929/494965;8669497,:8,88;938-1:149756895//1522%:089')21/557-8:8:96;8627'8;6/8,451-,7698/6/84:4144,80-;9566865+217888977/4:800673-4/57%978:;9/555.9962-'-',/.5$541645-1239;8:57751.25/555;567;89/:68269587-:756979589;4946/145504:;68301/2587460/66:.982762:2598707/527:1888782308*9:992;5:9:659562552.)$1127266914:6876427:+04847159874883/97644834/-826754564676/.34,081821*03/+46707-+,/67%6:/884844653525*7*53993;29837189548/1:48,29-6258:7919:3797..3%:,62,0%34-774883:7772923223074:85/1506)858815:953894.9;58.*316,5877/72,78:+9193966524:9555+42905'3226637889086235402,22*621/*+'+2/.221-'&*,3241&--/,2)013.310-1(),73/875:5589404455:78/745210576077//502%975:877313741.567*6/27366:913133,561*/3-)745285/65953.1//71,1/5878:::96:894,,10'/-/01-).15,106,.6)3643495372(0330432(78101017651666,//7130&1.5/824-778-41.53289397:881447041/2545/4193-9//51595.40445/,48446-678785217+23/2-364++,,++25777,)-560*&0'.0304469904/2)5+5628974,2/)-53:564,-741'3/+,6897,31453/54-4916:264410438)1/2886244,5:;574:5967:9784571,98647727:52704:56:7/6255/,&/18742152,$(*62.1349;22142972+,7,425-,+)-.$+(++11+..+&$02821,,-/2/*/+++,-%,41+(&,044..'%-,*',2,6,865688-,*.3+.0.+.2-/017+'//**+,00&13/0231-/023$21//132730,.22/.123*4310/344.3.71+-0,3%273455415145351550+)*$1059:6;9:;2746,86627787715:71*868;8:7=;26082759==89:927:==::=58>8<=<22<9794499<;:963=<9:;>:<=7.9297-==:5.;478+823:8;28;9/=8?:>*9=>8==<.;:<;7:6<8<>==: @rCer/2399/1930_66_CCS ATGGGGGAGTGCCTTGCGGCTGTAATGGCTGCCCCCAGTTGGCGCGGAGCTGGGCTTGTTCAAGAGGTGTTAAGGGTCTGGCAGGTGGCCCTCATGTCGCGAGGGAGCGGGTGATCCCTTTTTCCCTCACCCTTAAGCTTCCAACGGAGGTGCGTGTCCTGCGTTGCGGGGTCCGCTTTCTCTGGTCCCCGCTTAGCTTCGGCTTCTCGGAATTATGGCCAGGGCTCTGCCCTGGACCACTTCCTCGGATTCTCTCAGCGCGACAGTTCGGTGACTTCTTGCGTCCCCGCGGTGTCCAAGCACAGAGATGAGCAGGATCTCCTCTTGGTCCATCACCCTGATATGCCTGAGAATCCCGGGTCCTACGAGTAGTCCTCCTGGGAGCCCCGAATGCAGGGAAGTCAACACTCTCCAACCAGCTACTGGGCCGAAAGGTGTTCCCTGTTTCCAAGAAGGTGCATACCACTCGCTGCCAAGCTCTGGGGGTCATCACAGAGAAGGAGACCCAGGTGATTCTACTTGACACACCTGGCATTATCAGTCCTGGTAAACAGAAGAGGCATCACCTGGAGCTCTCTTTGCTGGAAGATCCATGGAAGAGCATGGAATCTGCTGATCTTGTTGTGGTTCTTGTGGATGTCTCAGACAAGTGGAACACGGAACCAGCTCAGCCCTCAGTTGCTCAGGTGCTTGACCAAGTTCTCCCAGATCCCTAGTGTCCTGGTCATGAACAAGATAGATTGTCTGAAGCGGAAGTCAGTTCTCCTGGAGCTCACGGCAGCCCTCACTGAAGGTGTGGTCAACGGCAAAAAGCTCGAGATGAGGCAGGCCTTCCACTCACAGCCTGGTACCCGTTGCCCCCAGCCCAGCAGTTAAGGACCCACACACACTATCTGTGGGAAACCCTCAGAGGATTGGCTGGCCCCACTTCAAGGAGATCTTCATGTTGTCAGCCCTAAGCCAGGAGGATGTGAAAACACTAAAGCAATACCTCCTGACAACAGGCCCAGCCAGGGCCCTGGGAGTACCACAGTGCAGTCCTCACTAGCCAGACACCAGAAGAGATCTGCACCAACGTTATCCGAGAGAAACTCCTAGAGCACCTGCCTCAGGAGGTGCCTTACAATGTACAGCAGAAACGGCAGTATGGGAGGAAGGACCGGGTGGGGAGCTGGTTATCCAACAGAAGCTTCTGGTGCCCAAAGAATCTATATGAAACTGCTGATTGGTCCGAAGGGCCATGTGATCTCCCAGATAGCACAGGAGGCAGGCCGCGACCTCATGAACATCTTCCTCTGTGATGTTGACATCCACCTGTCTGTGAAGCTCCTCAAGTGACCACCCTCTACTGATCCTCCCAGGACATTCCAGCTCAAGCTGCTGCAGGAAGCTGACCAGCAGCAAGGACAGAAGCTGACCAGATCTGTCCTTGGCTGGGACCTCCAGGACTGGTGAGAGACATGAACACTGACTGGCTGCTAGCTGGCCTGGCCCTGCTGAGTCTGCACAGTCCCTGCCCAGCTGTGTCTCCTGTTGGAAGAAGGAACTGGCCTTAGCTCAGTTTCCAGGTGGTTCCTCTGCCTGGGACCACAGCTACAAAGGTGTAGCTAAGAAGATGGCTCATTGGTGGGAGCAATATCACCCTACCTCCAGCTAGCTATGGGCCCAGAGTTTCTCCCTGAGTCGCTGTTGCTGGTAGGGAGATTTTCTCTTCCCGCCCTCACTTCCTTCACCTTGAACTTGGATAAGAACTCATGTCTCCTGAATGAGGTAGCGCCTTCCCTCTGCTCCCCAATTCTTGATCTCTCCCACCCCATCCCTCTCCCAGTCTTGGATACTAATAAAAGACAGGCATTCTGGTTCT + 6>CAAA;=);;C@C7<:>B=/?>:;@9@A3=A2;:1736145:3B5=9449:B;>@C>>A$.:/@A>@==>A@84?A2<@?956;<25=<*>BB@04;*:?3AA?A=7>?@8@:3:9>=7;@;@5A>@9=8;96<18?/74759/:C@B3>>B3@A;685:99*7:=4@7?=<3<;C?C>>;;166;9;A;6<<55?8:AA18.7??3;<+?;>BA?6@B?<>8;4=@=55+9;9A8=>9:>>>=9;@=4==A=<68:/-83?9B;7/42/,202/:=:>=;>:0.B=<=72<@%0=/4792768;4&1:-A@;9=@A?572:<6><<>2?70A=?3>;=::;?9B9<>AA;9@A@BC7'9;?06>8=3>5;5989289A==A=@@4:::<8??5>9>78=@6@8??::/?8AC@B89@>997=:::93-7<9?@62;8?68+9;877B?;>==:36==689@C=@:B31<>@7@A?@<>;=5=>=8>1B>8:->775?A<>>A;@::>??=6?;<9@A?:?==?<=>;<<3>:C@A>?=4>4<7:8B@@ABB5A@>.:97*6%4=8=:<,;6<7;=@<>=:96?>5:/0>6<;88918>:79=9>9==6<;8=13;>A5<86/703004>:5/384/=>9?27*2$2(<:88;8=@2:;977%:<56643<::7.02=7A;:626/3<;<8;>A:69155242;202242&1784867:19;:6:;;77<=@<@3:=:=,<97C:9?@95896496C57:=4=>B6??A>B@7A2:3=4;C99;8<979<5;25:34<95;24.(12*2,0-+1:228-5176(99:14:=6:=855,13%7,7577169<6=4<48<3922)744*6069508<=6776(3:66874571.&50534-9;=<=722152461<6><;3837+68:15<;*54<4:936=442,4*3/=65=::>=666-7.673313//3+/2.+4%(56893338664*372458:,>:;=759>>(8353:3?888?6?9>:7?885=5*:3143=87=<15:445*;9<70?:8=707(;438>3<>5=3636:+44:4>>-;<955;3344:49;781:.69;984>777/5;:)4:::=4?=:@<3=<:60@6<=:>=@2<5@?799<5?;:1=@@>2;3/5A/:A4::;?6B>B>3;>@+;A9<<9$:771A37>@8?<;;9@?BC>;>?<;@8@>;>A?=6=:B5>5:/5>$6>%6B7=?B;C?>?::51=A>:7;@=>BA@AB3?9>C:>:26BA>;957?99A:7<>=BB3@:?96;653538825=8=<95=;<6:92:6A*03B+?==<-779;//3?3C>>:@AAA38(A>9>A34'<4:%?9BAB?A?:AAC;<2@54?99A><;=>@BAAA2CC5=@:AAB4@>BC@B>>>0,=;=65A@A*<9;??>A?8==;(78/1=;=<;:;6859.AC=;C=@,AAC>:>:8@FD@:C=*+'@,AB&7?1,AABFF?E2F>BC6C>>:;=@,>1C@EB*=;?:.>?BAEAEEEG/@B;CE@?CCF@@C @rCer/2400/25_2143_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCATAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + 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@rCer/2407/25_2010_CCS ATGGGGCCGAGAGAAACGGCGCGCCGCGCGGAGATGACAGCCGAGGAGATGAAGGCGGCCGAGAGCGGGGCGCAGTCGGCGCCGCTGCCCATTGAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGGACCGAGTCTTTGTCCACTATACTGGCTGGCTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCAACCATGAAGGTGGGGGAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCAAAGATTCCCCCCAGTGCCACACTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACAGAAGAGGAAGATGGCGGAATCATTCGCAGAATACGGACTCGCGGTGAAGGCTATGCTAAGCCCAATGAGGGCGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGACCAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATTGTGTACCTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCCGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGTTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACGGTGTACTTCAAGGAAGGCAAATACAAGCAAGCTTTACTACAGTATAAGAAGATTGTGTCCTGGCTGGAGTATGAGTCTAGTTTTTCCAGTGAGGAAGCACAGAAGGCACAGGCCCTTCGACTGGCCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCCGCGGCCATCGAAAGCTGTAACAAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCAGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGCCAAGGCAGAGGCCTCCTCAGGAGACCACCCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCCTCTCCACCAGCCCTACTCCTGCGGCTGCCTGCCCCCAGTCTCCCCCCTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGACCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGGAAGGGGGAAAGGAGTAGGCTGGGGGATTGAGGTGGGGAATCATTTTAGCTGGTGTCACCCCCTCTTCCCTTCCCCCTTTGCACATGAACATATGTCCATCCATACATATTCATCAGAATGTTAATTTATTTTGCTCCCTCTGTTAGGTCCATTTTCCAAGGGTAGAAGAGGCAAGTGGTAGGGATGGGGTCTGATATGAACCCAGGGTGGAGAGGGAGACTCCTGGGCAGCCGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAACGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCCATTTCTTCTCCGTTCCCTTCCTCACCCCCAACGGTGTGGCTGATGTCTTCTGGTGTGATGGTGACCACCCCTTGCTCCCTGTTCTGGTATTTCCCCTGTCAGTTTCCCCTCTCAGCCAGGTTGTGTCCCGAAATCCCCTCAGCCTCTTTTCCGCACGTTGCTGAAGGTCCAGGCTTGCCTCAAGTTCCGTGCTTGAGCAATAAAGTGGAAAC + HI:JGD>=$$=>/8>DG==JEKJD4>GD-F9B4DDHEJKC9EHICC:EAI?ICA:EJJKFAIIK:KHHGKIKKKIBHJCIGJKFJGJEJCI?KKGKKKKK8KKJIGKKEKKCKKK?KKAJKKKJJFE&@-1E:KJJKIKJ8J;5C;KCHI3KBKHKJGKHKKC0JGG>HDHGDJJIKFGI/DKKKJKBK?E=KFKIKKGK.IGJKKKDKKDE;;KIIK9JDIJ>J%IKFHKJKKAJKKJJKDKKJ7AEGBI@EB:HCIIEJE?HEKEK>JHEJGGCJKCEKJ?CJKHKKJDKIAKKJKKGJKKK5GHKFKK4KIJIKDKKDKHKBKKKFIKFK,HJK;HKJJKHKKFFFJJKKKJF>KKJI?EKKJKHJKIJKICGDKJ1JKKJGKKKKKHKAKFKKJJJJKIKKKKKFJKKBKJIKCJIKKDKKI9CBJCKIKIGKKICFIEKKBJI6J'JKKKCKKKKD9BFKI>KKKIJKGK;JKH;KKJFJKJ@KKIKKKKJHKKKJKGFJDKJKKIKKJEK6KJKKHKKKGKKCJJKKKKGKKDJKKJKJEJKJKKKJJIIKJBKKKJKIAKKJKIJJKKHHHJFJJIHJKJGKGK9H/KJKKKKICI9KKGIEFIKJDKJJKJIFH5AJKG/7HKJ>KJ1DCEKJKFHKKKKJJKDKDKKJKIKKKKKJJIKKIBCDHFHKKKKKKJIHJBK;KJ6KFIIHFJKKCHJKJ/KKFI=KKKKGFKHKJ@KJKKIKKKKKEBGBIIGKKI:KK:KKKIBJKIIGKIKKK>KJ?KJKFFJJJKKJK;KKFIGKGGB:IKKKAKFIHJKK?KIIJJIKKKKKJKIKHKIHHHFKIKKHKG+JHD>KGGICFKIK7KIBJKAK1ID-?EAJJJBDJDKK3EKBDGGHKKCJKIKAJCI?@,AFJGKJJ=KJJIKKK?JJH2GKJCKKIFHD=BJGHHGKFKIJFJ?HJ=9FAHJJ6?BHIEJKKHHKK @rCer/2408/1808_60_CCS ATGGGGCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCCCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTACAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCTTGGATAAACTGAAAGCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTATTATGTGACTATCATTGATGCCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTGTTGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTCAAGGAAGTCAGCACTTACATTAAGAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGTGCTGGCTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTTAATG + KIKKKIJKKKH5JIIGBKHKHIKKJ=KHKKKIAKKGJE9KKK;H9HKGKCJJII2HHHFJKJCJJDIK8JEKKK4JKIJIECJJKKAKFKJIJGCIJIKAKDIKIEIIKJ?K=KKKHHKHDJKJFKKKKHEIJKCKIKIKKKDIKD>IKI33IFKDKKJIKKKJGKKKK5DG>KFBKKJKJJJ,KK?GIIKEKKJKBKKKKCIBGJIKK;KKDKFAKIHHFBCJAJEGI;EKH:CG0DH?BI@@HDF=CB?C?JJGDEGJGJIHDC7HGBEG>>:KJJIIGDIKAHEHJDJHGFJKKC;B<9DFIHII:KKIJI;HC?FFG6>:KKJHGJHK=KDIGDI3C9JGEFDCFJ>BHBJEIGJK@IIEBF@CGHGCJBCGF+EKBJJH4KIIH@DEHFFJG8>KKH?JJIJKGKGDJHJJ@KGBIEJKDHHDCIFI>CFKEKEHIIJJD?G@BGF:D:CCJHBKDDG3G5HHKEIFJGGDG@JAGAIGDGD?BJDHJJ@GKAEJHIICFDCIJJ:@I9DHGK@KGJFAGEHEFIJGKKA>KKGJBCIJHCJJI>IFHHJKHEIIECKGBEKII;CDIGBE?6G=;JCFJHDGI1KIAJKBG3JHHJIHKGJHIHBI@HHH+GHJKJ1IHBJF?;JHG0E9DFHKFHE:H?8IE>JJGKHIIJEFIF9IBDE=F=BHG0GD6947@DH6DCDFGHDFJK>IIGK9FHHHJJ9DJDJKAIGAEH=7;KJFIK@DJ>GK5GHKHHDIHGFEJK5H=GEFJI9KEFBGG@I>KJH6JJGGH0JJJCB7I@IKCJFHHHHCF@EKGJJEJGC>KFJF<>IIBEJGIH?GJ7GJHHHFDD+ABFJ5IJ@IGDFJIGJKAIIEIAHD29I6G@IIJGGIIIK?JEGAHHEEFIEGIICICCG6:G9FEIGDEHDCJGI>DFCFI@FH@C@@GHCFBHIGE=HIIAEGDB9EE>AGBI@AFFFFEFGIJEABC@A>BEDG@-DCGFHFIGHI?DI@ACD8HFIB@@EDC6EGFHG>4BDGE?G;CBFFGF0CCG7BBFH?@EIHEF3E??H@GI8GGBEH=FF@CFIHG4GE9GCCBE@FG/GHI2EF>>BC9FE3FDDGH&EJI@1<1778867)61=234)658,)315-2,-%-/98.74896,)3-43$2.4/564.838-/:2+..(0497+529+3;59:9::05;53%49;973878%37:2200/013%05&35%03,1,9:96771&98.1;5977(239/4:-3,:0:5778+*/-86:93&0/.(*+-5(630-48:-6356&083476077,604:7.5.:3..1-08;62555638718*&-8,;792-28,969988/-2%-3/284&438(958:60/44%)'.27)/,3%5-668+85758:/.9744-5*2*5)7'*8-52/0--4:*1632'4*55274:,88'5//:$,0/3152/4*+3///34%4433%-%*/6.0/4+1-/%.2*+(3/),3-2+552,.04/31,+6)2.24%1,+'+,(&/.%.2412/1%.,413*05612133+1-$',0&2*132/4+/(.'-35624611-0622//,.05024*,-)/.(0($'***),%-0.-4/../231/,).20)/-030310,.0'15..$.&//,*2410543,//1-),446200%&*/42&112625335+6,+60-36,+3)1354%23.3-46033300.5).)30/2(6.3+-4*0/443(13,0(./''/*&'524/+.52+06-315255*.-5531/2*42.0/.%0,/).1+651/1'-3)/33).401,&-.1'06220/25402.45060/13#(*4,6341+1/3+/1014534'#%115543)1(.253000261431)6+$,&,56(/,615--'.)/23.,(3#344/4(/(,,0,3/-00*2,/+1/),4246/2(254,)1,'$'2,302560+&&#(&152,//21''.54.-.20(/1,#-#$&.*454501533)26.4.,.,1).4214501/5,0*-01+/510*4(0414460362+53..05/142552))4(-2/015531//165-4//33120++/4,--)(60516102/51-++(/-5.4*45545550*35*/,0114/.)512.0/1*365320%31(+3)1,52.3.2521-1112-556240144,6,1/00)4/115+56513',45)312355220&4.423-245141241253/05134.0555.0304.60/2(1/'2/214-3/5510523)(*2)42552)/&.,/20+'4/4-2626/2(461210*2%-043442-+4$,3320534252644340513,)05)1/55+03)2*33*66*12&.1//20//)'4501504555454/555505002.40)-2(105555'/066-0'+021-424/142,1$+24113-01.6-12.1-01111*++)0,.1-*0,00.01/11(,10.0,,&+'-,)$''.0',,100/*++..)0-0/,.0-1--'*,.)0,10,,00''*/),2,+*$01/%-)..),---+,('/0.0/&.0++).%/0-%*/+-.00/.&0110112--+/,,*00010++,#,**2--'-20--1.10/-10*/'01+,++'0)01+/0.&/)011/&,-+*) @rCer/2411/2047_57_CCS ATGGGAGGCAGCGCGTGGCGAAGCCCTCCAGGCAGCTCATGTCCACACCATAGTGCTGCTTCACCTGGCTCCAGAAGCCCAGGCGCCATTCCAGCATCTGGTCGCTGATGGGGGCTATGAAGAGCTCGGCGGAGGCCGGCAGGAGAAACCGCCCTCCTTCAGCCACTTGGTTCGCGCGTGGAGGACGGAGCTCAGCATGGACTCGTGCAGGAGTCCGTAGCCATCCATTCGCTCACGATGGCATCCACCTGTTCGGCAACTCCACAGTCTCCACCGGTCCCGGCAGGACGTGCACCCGGTCCTCCAGCCGTTGAACCTTACCACCTCCCGGGCCTGTTGCCAGATGGCGCTGGCCTCTACCGCGTACACGCGCCGGGCCCCGGCCTGGCACAGAAGATACTCAGAATGCCGGTGCCCGCGCCCACGTCAAGTACCGTCTTGCCTCGCAGTGCTGCCCAGTTCCGCAGGAATACCCAGGCGGTAAGGCATCGGTGCGGACGCGGTCTGCGATCATCTCCTCGTGGACCGAAACGTCCGAAGTAGCACTCATAGTACAGCTGGTCCGCTCCCGCTTAGTCCTCCGGGTCGCTCCAGGGCCGCCTCCCGCTCCGCGCCATCTTCCTCTTCAGCTCCCTCCCCTCCTTCGCCGCCGCCCCCGACTCAAGCTTTCTTTTCTTGGGCTGCGACATCTTGGCCGCTCTGGCCGGCTCCCGGCGGCGTAGCGCGGCACGGCGCGGGCTCCAGGAAACGGGCTTCTGGACTTGTAGTGCGCGCTTGTCCTTCCTACTTCCTGCGGGGTCGCCTGGCCAGCAGCGCGGAAGGTCTTCCGTGCCTATCCACGGGAGCTGTTTTGTATTGCTCTTCTGGTGTCTTGGCATCCCTTTTGCCACCCACGACACCCACATTCTGAGATCCTTTCATTCCCCCTCCCACCCTTAGTTTCTCAGTTTTTTGCTTTCATCCCTTCCTGAAGTAGACACGCCCACTTAAGACTAATAATCCACCTTTGTTTCTTCTGCTCAACTCACCTCTGGTGTTTGTTTGTTTGTTTTGATACAGAGTTTCGCTCTTGTTGCCAGCTGGGAGTGCAATGGCGCTATCTCGGCTCACCGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCTTGCTTCAGTCTGCCAAGTTGCTGGGATTAACAGGCGCACGCCACCACGGCCGGCTATTTTTATATTTTTGGTAGAGACGGGGTTTCTCCCTGTTGGTCAGGCTGCTCTCGAACTCCCAACCTCAGGTGATCCACCCGCTTCGGCCTCCCAAAGTGTTGGGATTACAAGAGTGAGCCACCGCGCCGGCCTAACTCACCTCTGGTTTTATTCCACCAAATTAACATGGCGGCACCATACACACACTACCGTCTTTAACTGGACAACTGTAGCTCTTGAAGTGCTCCAGATGTGGCAATTTAGAAATTGCACTACATATTTCTCTTTTCTGTTTTCAGTGAGTTAGAGTGCAAATGTAACAAATTAAAACCTAACAATGCAAATATTGATTCTGATTCCAGTATGACACTAATTAATTGAGTGATTTAGGGCAAGTAATAGAACTTCTCTGGCCTTCAGTTGCCCATTCACCCACCAGAGAATCTTCATTGCAGTTGGGAAGAATTATGTTTCTGGTTCTACTTAGAGGAATAGTTACTCGGCTTTCGGCCCTGCTCTGATAATTCTGTGGCTCACTCAAGAGTTAAATCCAGAAAAGTGCAGACTCAAGAGCCGTCTGATACAAGCAAACTCGTTGCTAGGTGTATTCTATATATATATGCATTTTTTTTCTCCCAGAAATAACGGAATCCCTTTCTTTCGATCACTTTCTCAATGCAACTCATTTTTTACTATGTTTCCTTGTCTGGGCAATATTGACACTCTTCCTTTTTCTCTTCTATTTTTCTTGTAGTCAACCATCAGCTGTTACTCTCTTTTTGTTCATAAATGGAAATAAAAATATATTT + ,++*$,+'%$#(%*)'%%+-.*'+*&),)&%$,-10,/((*+/)/,,/*/++*&+.(1120,,.'-1,0-/)//.,///&)101/1**0*2)*12&-0.+$-46356403-14)533.000&)44/56-41,40&4,1$/20,/0.%(21215)251311++0,-.650*1+030/.026442*.+1()/41535+(34-,-154,*426/142511&002&0250/3+-'/21565311*0.+0-11/)).)%'))*(-01-0564/-+6/0+&0--26,63/(301*11-,064-2(+*)$'*1,,#01+/6/635/0-%/1+2.0)62/1%22/,0/%.3/5+((+./,(.'$/0+33443/1..,5332'66*/11'651*13%,-/-25/..011.3/(1*//2*.)00-,&32/.0%,0/354,+-,3/1542/51)/1131..)+--12.-'100,,/12+,%/232-,'+0.**(%0.)*00/(1./2+52..246:898(711(3886148811+.66774).908565%5745.137/8342/16267/+'65%2334725536603:266273(708509-334070-:4368,.51:66/6954573,,+436/986306948:73'294;8:95186028875'716+381:9;736588)3;2640/2261)23(&9+2+.+14+3/345)5,25::15468'-33986/0-&/448+:8788-849356054..02%,6/.23'24530,/414445124(4+7222965:96893685949827/:9995;9::77925::4604*12:27.744:39775)24990),15354/%.&0-,(1-32057.-+*7594:219762,667198,39:1-461'.77*89:96955)48152761-682301618990869161442/(4996672233$1/13&-#(,:*9,81640100.1%-,3278(7682857/35:1.6/46'-6,98,-88+'5134:3.6;8724..%56/;641:4/232.-,2%(322$,6127499342(657-56486.99.6(/8::/4+3347076*1998859897431348.348&,.58573'57*644&:2+7+97532(*//2'48;51065:88939,45,(92:9/18*/$566.::/3,37.4;84490:.8-8668687*,435881)619578703425%99+227;7/37*1,+7.1)-10325275467/54/:-:668:9656374'655/8/3,87-4',26+85(-2+)#,4%01.+59+846763:;585%372420'5+570+95264/66:0787(0/25&72,51'1'324-251882..1011*.4/$+//022(51+10%7.,27-14:575599::/11.55.,(521;9878988:-8:/78064:912)19689:02*164*)/,/71%812665,8554'3442778514499.55680*47'42577&.(59,48.54436*)64,425-1.759585797:537(85/:44,4-7342251**.(3+8/29-%*/-307965959989:28-6$.28:3)84+5:354:9-77.256791-0:399;845979.15)6%*:07054683*497.868039;4399:495-038/6975;4866'53%6/%,7,2667547073468:;88592317;86365,35.89:63685'86/4-876+32-4--6/5356236648*-,33'/33562/01/312-()62)*)#$()-/-,12+,131///4'42'311155.1.)25,3&261133,0662414021162+32/5111554,23366666-53545261141603,//./&16.565024,41-11&2,5533+54/50313331/&./$44/415412'2/).,)2210/224/./.)0'(2-/1('+#0-%34.+231.$02/-0.3 @rCer/2412/24_1857_CCS ATGGAGTCCGGAGGCTGCGGCTGCAGAGGTAACGCCTGCGGAGAAACTGCAAAGATGCTGTCCGTACGCGTTGCTGCGGCCGTGGTCCGCGCCCTCCCTCGGCGGCCGACTGGTCTCCAGAAATGCTTTGGGTTCATCTTTCATTGCTGCAAGGAACCTCCATGCCTCTAACACTCATCTTCAGAAGACTGGGACTGCTGAGATGTCCTCTATTCTTGAAGAGCGTATTCTTGGAGCTGATATCTCTGTTGACCTTGAAGAAACTGGGCGTGTCTTAAGTATTGGTGATGGTATTGCCCGCGTACATGGGCTGAGGAATGTTCAGGCAGAAGAAATGGTAGAGTTTCTTCAGGCTTAAAGGTATGTCCTTGAACTTGGAATCTGACAATGTTGGTGTTGTCGTGTTTGGAAATGATAAACTGATTAAGGAAGGAGATATAGTGAAGAGGACAGGAGCCATTGTGGACGTTCCAGTTGGTGAGGAGCTGTTGGGTCGTGTAGTTGATGCTCTTGGTAATGCTATTGATGGAAAGGGTCCAATTGGTTCCAAGACCCGTAGGCGAGTTGGTCTGAAAGCCCCCGGTATCATTCCTCGAATTTCAGTGCGGGAACCAATGCAGACTGGCATTAAGGCTGTGGATAGCTTGGTGCCAATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTGGGAAAACCTCAATTGCTATTGACACAATCATTAACCAGAAACGTTTCAATGATGGATCTGATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTGCCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTACACCATTGTGGTGTCAGCTACAGCCTCGGATGCTGCCCCACTTCAGTACCTGGCTCCTTACTCTGGCTGTTCCATGGAGAGTATTTTAGAGACAATGGCAAACATGCTTTGATCATCTATGACGACTTATCCAAACAGGCTGTTGCTTACCGTCAGATGTCTCTGTTGCTGCGCCGTCCCCTGGTCGTGAGGCCTATCCTGGTGATGTGTTCTACCTACACTCCCGATTGTTGGAGAGAGCAGCCAAAATGAACGATGCTTTTGGTGGTGGCTCCTTGACTGCTTTGCCAGTCATAGAAACACAGGCTGGTGATGTGTCTGCTTACATTCCAACGAATGTCATTTCCATCACTGACGGACAGATCTTCTTGGAAACAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAACGTTGGTCTGTCTGTGTCTCGTGTCGGATCTGCTGCCCAAACCAGGGCTATGAAGCAGGTGGCAGGTACCATGAAGCTGGAATTGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCAGTTTGGTTCTGACCTCGATGCTGCACTCAACAACTTTTGAGTCGTGGTGTGCGTCTAACTGAGTTGCTGAAGCAAGGCAGTATTCTCCATGGCTATTGAAGAACAAGTGGCTGTTATCTATGCGGGTGTAAGGGCTATCTTGATAAACTGGAGCCCAGCAAGATTACAAAGTTTGAGAATGCTTTCTTGTCTCATGTTATCAGCCAGCACCAAGCCCTGTTGGTACTATCAGGGCTGATGGAAAGATCTCAGAAGAATCAGATGCAAAGCTGAAAGAGATTGTAACAAAGTTCTTGGCTGGATTTGAAGCCTAAACTCCTGTGATCACATCAAATACCAGTTCAATTTTGCCATTGTTCTAGTAAATTAGTTCCATTTGTAAAAGGGTTACTCTGATACTCCTTATGTACAGAAATCACATGAAAATAAAGGTTCCATAATGT + @9&<;/<4?,B=/>>=??6:2:<'9@8>77,:6;@5>7,0A@><<=8?@>:40<8@<+@?9?>6?53@A>)<@4=8>66:C=5=21=-=B8(>A?;(;>,:*)$8@?2?7/@:?*('>98761B?&><'<;<=>&@??7=@?>:BB8?883C&>=/A;;+2;5286@B@:@AA;@/@888:;08?9-C@5;2C<=>56FH>J<93DFC<2C>8H+IJGI@KFCEEHJKB>FK@H=J@%HH@@BG?K?JDGK9HFEDEDHKGJBE:KKIIGKE1BH7FKII-H?HIIK2KKEII;K?EJ8H?B2C=JAHEK2G3JHGIE6I>F7>EDKFKGHCKFK@K?J>A958JIJJGHIFGFD:FHJ;KHBK9KE:E.IJGC6EJIK1KI9KKK/KJI1G=HGKBKGKKB5DG=KJKIFKII?G-@HJKH:KKC6E9KKJC9KAKKHKK@CKI@KKKKK>KJJJIKJJIDKG>5F=-9KEE+KIKJ4KGJJIGG1K6KKJI8J@K>KCHKKJKKGA*KKEH>KKDKGKJ8H>IKHIHCKKKKKKJKAKKK)KIIBJKJKK7KKJKK;AKIKKKJKKIKJHCKKKK9KKKKIKJK?KKKKKKKKKDIKKFKKKKKHKKGH@KHJIKKKH?KK=KGKHKKKIKAK?KKIKCDDJ/KKAKKKI@KK1KKKK@KDJKKKKK7KCKJIEJKF>HKKKKIKKKKGKKKKKGKKJKK8KK;KKKKJJKKHJKKJKKKKKKKKKKKI=KKKJ>JKKCKKKK%KKKJKKAKKKKKKK=KKJKKJKKKK*<)6IKK?GKKAKKKKJKK>KKIKJJGJKKKKKJKCKKKKIKKKFKKKKKFA&KKJJKKFKC7'KCJ2KFKKHKKKKKKIKCKKKKKKKJKKKKKK0KKB=DIJ*KKKFKKKKKKJI4KKKKIKIKCKKKGKIKKKJKKK&KKH8KKIEKGKJKK=KKKKKKK@IKKKKFKKJKKKJKKKKKJKFKA-KKHJ?8$HAJKKKKKF.KK9KKIKJK@KKKKK?KKIKJKKJKKKKKKKKKJKKKKJKJKKKKKKEKKJJKK'KKCDK>2HDKJ<:KK4KKKCKKDKJGKKI=4KHKB%E$BJKHKK)KKJK8KKJKKK;K;KKKK3KJEKKDKDJGKK,KKBKKKKKIKK:KKKK3KKK-KKJKJJCCE6@>;D3DB?@BB&?BACG:E?FD=:DD??6C1EAGAEB9D?BC;A7?<@BA;B@>EF>CDDA==AE?C>'F;B:;B,=7B:C@5:E>@B@89;969;ABBA=99E57A-EDG:EF7DE/E@?<5=?-7A-073)<>@-<BE>4B<=BA/?D@/A>:B;CCBBB%G;DEC(B4E>CCFBGD8?BBCBD*87E@>=;CD3FDE:B?@:5>--E9?BA>;DDCA@=BFAC@3>CEED'DABDD9<:CAB@F?3=>.?1@@EG9DE?:?9BA7%0?A$@G3E@G=DD1.C3A?BE>?C&@GA9B>E@B;?9>FE>D;:;DCB3>@*8A4A?CF>GBFF??1G>>@CF>EE;FFD>B@54;4=ABBDBG;?8;?:EGAEFFED7AEC@D06AB@%1D6?@>F?9;F9DB>BF@B5?0;@DF>AB@G@EDCGC>><)??)5BEB<=D:E:::@@1@D9FAEC:@E8BBC<=;EE=EEC=8@D=<,@4%<=<<@A%?7@;<%<96=/3;A<-;C?B>C?B>B@B6B??:877BC4B@=:=;'@C>:$-586@A1@9@=(=@=@C2C+=B:=C-C5?>>>=::%;@@B>B?8A5=2?9<>:>>@?7B??BA-7?0<+57=,9A,;59:7AC0,8;0;AC.C?4A3=;A2>>=@C@=<.010=@<=;9<;*28079/"+9+86;;:=@@)>6A:<<967=7?=?C=BC2<<85@>*;?=@9B076$75>;;8>>5:;?@0A>>AC<@B4@@BBA;?>=;@>7/9@43@,>A>6=<.>?<;;A?08->A6A=@B=5/=6=>4A9B8@@>(=9;?,C8=?CC2BB=?>AA->B.9??C98';0423;29AA(A*<=A7%9A:8-=>>:6=B>B=4?@CB?=A>;B9=5@A+:@94?%=@A6?;;B@8;=8:8?)9A9;=:@=B7<=A??6AB8CA::*=)2>7>;>==0?7<;=8=A?>C=CBCC;C5B@BA@5C=/>>A04/C5>@;9?C=><<@/:?<@C<6>5BB9?A:?9=AC;79>4A:476<8?;C:?,7<<4=9==5159:5=9<:=3<>:=?86>:=<;,-9.;$;>>><<;3856?:>=:88<<698::64588*04%275;8:=;-42>=89665>;;?8%;=>>??<6=;<>>3===3<;9:8895==9:9/8>=,<6<37:08'=<:0/41:=3??;:?8:>9<9:;#7<==4,,8383:8>898<.;<0>:=)>.75>==:<<2<788?8>??;=3?;98:)897:3;0==8;049<;,=><8??5<=137.934381;;92<=$:08>7:;;9:%9 @rCer/2418/25_1787_CCS ATGGGGGTGCCGCCTCTGAGTAGGGCGGGCGAGGAGGCAGCCGAGGCGGAGCTGATGGCTGCGCCGAGGGCGGGGCGGGGTGCAGGCTGGAGCCTTCGGGCATGGCGGGCTTTGGGGGGCATTCGCTGGGGGAGGAGACCCCGGTTGACCCCTGACCTCCGGGCCCTGCTGACGTCAGGAACTTCTGACCCCCGGGCCCGAGTGACTTATGGGACCCCCAGTCTCTGGGCCCGGTTGTGTGTTGGGGTCCCTGAACCCCGAGCATGTCTGACGTCTGGGACCCCGGGTCCCCGGGCACAACTGACTGCGGTGACCCAGATACCAGGACCCGGGAGGCCTCAGAGAACTCTGGAACCCGTTCGCGCGCGTGGCTGGCTGTGGCACTGGGCGCTGGGGGGGCAGTGCTGTTGTTGTTGTGGGGCGGGGGTCGGGGTCCTCCGGCCGTCCTCGCCGCCGTCCCTGGCCCGCCGCCCGCTTCTCCCCGGAGTCAGTACAACTTCATCGCAGATGTGGTGGAGAAGACAGCACCTGCCGTGGTCTATATCGAGATCCTGGACCGGCACCCTTTCTTGGGCCGTGAAGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCAGAGTCCGTGTGAGACTGCTTAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTGGCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGACGCTCAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTGCAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGACTCCCCCAAACCAATGTGGAATACATTCAGACGGATGCAGCTATTGATTTTGGGAACTCTGGAGGTCCCCTGGTTAACCTGGATGGAGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTTGCCATCCCTTCTGATCGCCTTCGAGAGTTTCTGCATCGTGGGGAAAAGAAGAATTCCTCCTCTGGAATCAGTGGGTCCCAGCGGCGCTACATTGGGGTGATGATGCTGACCCTGAGTCCCAGCATCCTTGCTGAACTACAGCTTCGAGAACCAAGCTTTCCTGATGTTCAGCATGGTGTACTCATCCATAAAGTCATCCTGGGCTCCCCTGCACACCGGGCTGGTCTGCGGCCTGGTGATGTGATTTTGGCCATTGGGGGGCAGATGGTACAAAATGCTGAAGATGTTTATGAAGCTGTTCGAACCCAATCCCAGCTGGCAGTGCAGATCCGGCGGGGACGAGAAACACTGACCTTATATGTGACCCCTGAGGTCACAGAATGAATAGATCACCAAGAGTATGAGGCTCCTGCTCTGATTTCCTCCTTGCCTTCCTGGCTGAGGCTCTGAGGGCGCCGGGACAGAGGGTTAAATGAACCAGTGGGGGCAGGTCCCTCCAACCACCAGCACTGATTCCAGGGCTCTAAAGAATCACAGAAACACTTTTTATATAAAATAAAATTATACCTAGCAACATATTATAGTCAAAAATGAGGTGGGAGGGCTGGATCTTTTCCCCCACCAAAAGGCTAGAGGTAAAGCTGTATCCCCCTAAGGTTAGGGGAGATACTGGAGCTGACCATCCTGACCTCCTATTAAAGAAAATGAGCTGCTGC + JJ1KKJGHFIK=JKKJ>KEJII0JJJ/HJIKJGJFGKJDJHKKHIKKJKJKIJJ=KCF>JKEB>KGK@KKJ3KHJH?JIBJFKHGHIKJKJFGKAIJ;KHGJI?GKIKKJDKI.KKKKIKKKKJJJK1HKKHB?KDJI4IKKEKJKJG>KJJEIFIKIJHKJKIKKKKIFKKJIFKIGKBKC/J9GIK:KKKK'JK+JHGKJJJII6KIIGKKGAKFKKJJI@GKI=KIFJHJKDKEJKKKFK=CD>F>KIGIEIJKKKK?FFIGKEJGKKKKKJKFKII+D=EEKKKGKKKDKKIJI7CJKKKKJKKIJKHF&CIGK>JKHKEKKJDKKJKK?FKKKKKIJJKCKJ9KJJKDKHKKK5F:??/7HB7JIKKKGKKCJ@KKJHKKJKKHFJI/KKKKKJK>JIJJEIHKK@IH'IBA>CKGK:KKDBGJ7KHHJEKJKKHJGK=B@IBGBCKJDJJJHKKEJKFJJJIKKJKKKHBIHC=KKKKKKJD7HKC:J7IKKKJKAKKKCJJIIAKKKKI5J?K@IKKIIEKKHKFKIEKKHIJKKKJKKFJEC?CIFKIBK@F@IGHCAIBJIJGKJFKKKKFJI=BKKKI6JIKKKKK?KKCJKKJHGIJKIJKJDKK@DIGI:KFIKKKKKBGJFKJJ=IJ>KHJIIIJKKHFEJKDKKJKKJFGHKDAKJGK<;J>KGJ;K@IHJII>HEIHKKKJJJHKJGIKCGJJJ4CIJHKJIKG5EGJKBJKGIGE5JEJIBJHKKKDK@IK@J:FKIJG7KKH&JIBFFFK@ABDI;H4:CJBAF>IF'AB?I6K;HJJJIFKKIJ8K7EAKJJKIKKKKJKJKKKJHKKD3KKKKKKKKKK@CKJGK6KJKKKFJF;FKKGKDBEKJIIIJFKI,HJJKKKFKKKKJGJKJ@HKKKGKKKKKGKDKJKCK8EJJKJKJJKJKKJKJKKKKIKKKKKJKKHKIG/KKKKKKIKKK6KIIJ>IJKIKJJHKAKBKKJGJKHJJFJ?KDKJ5KIJGEE@KJAGJKKKJKKDK1KJKKKKKKK4D@IGG2HJIKJEKKIK:BHI+EJJH5EGJKKKIKJI.FHKIAKJ9IKHGJKKJJKKBJKFKJFJKKKI?KKKGKJKK+JHJKJIKKJKKKBGKGJFGJBK?KJKHKJKKKKKJ8DEKDKKKK=GKKCJBJI@IKKKKJJKEKJKIJKKJKKIGKKGKJJHHKKKKJKIKJIKIJGJAKKJJKKKKKKKKIKIKKKJKHJJKKBJ8KJ @rCer/2419/1945_52_CCS ATGGGGGATTCTGAGGTGCACTGTGGAAAGGGCTTGTCGCTGTGGTGTTGCAGTTGGAGACTTGATTGTTGGTGACAGCGAAACAACGATAACAAAATGCCAGAGCGAGATAGTGAGCCGTTCTCCAACCCTTGGCGCCCGATGGCCACGATGTGGATGATCCTCACTCCTTCCACCAATCAAAACTCACCAATGAAGACTTCAGGAAACTTCTCATGACCCCCAGGGCTGCACCTACCTCTGCACCACCTTCTAAGTCACGTCACCATGAGATGCCAAGGGAGTACAATGAGGATGAAGACCCAGCTGCACGAAGGAGGAAAAAGAAAAGTTATTATGCCAAGCTACGCCAACAAGAAATTGAGAGAGAGAGAGAGCTAGCAGAGAAGTACCGGGATCGTGCCAAGGAACGTAGAGATGGAGTGAACAAAGATTATGAAGAAACCGAGCTTATCAGCACCACAGCTAACTACAGGGCTGTTGGCCCCACTGCTGAGGCGGACAAATCAGCTGCAGAGAAGAGAAGACAGTTGATCCAGGAGTCCAAATTCTTGGGTGGTGACATGGAACACACCCATTTAGTAAAAGGCTTGGATTTGCCTCTGCTTCAAAAGGTACGAGCTGAGATTGCCAGCAAAGAGAAAGAGGAGAGGAACTGATGAAAAGCCCCAGAAAGAAACCAAGAAAGATGAGGATCCTGAAAATAAAATTGAATTTAAAACACGTCGGGCCGCAATGTTACCGAATGCTTTTTAAGAGCAAAGCATATGAGCGGAATGAGTTGTTCCTGCAGGCCGCATGCCTATGTGGTAGACCTGGATGATGAATATGCTGACACAGATATCCCCACCACTCTTATCCGCAGCAAGGCTGATTGCCCCACCATGGAGGCCCAGACCACACTGACCACAAATGACATTGTCATTAGCAAGCTTACCCAGATCCTTTCATACCTGAGGCAGGGAACCCGTAACAAGAAGCTTAAGAAGTAGGATAAAGGGAAGCTAGAAGAGAAGAAACCTCCTGAGGCTGACATGAATATTTTTGAAGACATTGGGGATACGTACCCTCCACAACCAAGACACCTCGGGACAGGGAGCGGAGAGATATCGGAACGGAGCGTGATCGGGAGAGAGACAGAGACCGTGACCGAGAGCGAGAGAGAGAACGAGATCGAGAACGAGAGCGAGAGCGGGCGGGAGAGAGAAGAGGAAAGAAGAGACACAGCTACTTTGAGAAGCCAAAAGTAGATGATGAGCCCATGGATGTTGACAAAGGACCTGGGTCTGCCAAGGAGTTGATCAAGTCCATCAATGAAAAGTTTGCTGGGTCTACTGGCTGGGAAGGCACAGAATCGCTGAAGAAACCAGAAGACAAAAAGCAGCTGGGAGATTTCTTTGGCATGTCCAACAGTTATGCAGAGTGCTACCCAGCCACGATGGATGACATGGCTGTGGACAGTGATGAGGAGTGGATATAGCAAAATGGACCAGGGTAACAAGAAGGGGCCCTTAGGCCGTTGGGACTTTGATACCCAGGAAGAATACAGCGAGTATATGAACAACAAGAGGCTTTGCCCAAGGCTGCATTCCAGTATGGTATCAAATGTCTGAAGGGCGGAAAACCAGGCGCTTCAAGGAAACCAATGACAAAGCAGAGCTTGATCGCCAGTGGAAGAAGATTAGTGCAATCATTGAGAAGAGGAAGAGATGGAAGCTGATGGGGTTGAAGTCAAAGACCAAAATACTATCACCAGTTACACCGGAGACCCTCCACAAGGATATGCTTCCCACTGTTTTCTTTATACAATTTCCAAAGGTTGCAAGATGTTTTTTGGTGGATGAATATAATTTTATTGTGTAATTACTTGGTTCCATTAAATTGGTTAACTTG + +24759*9:.4,9:695573699-8&*2*27*50&614:65665075:723102+:67741:5886(0:1;9183-957740)664731563562/&475,04/9:672.8433346:252&220,6-8:11'1039:601/435555:80634610/045:22852/:08.7'5;9;7::;;82-3/11221-5;45/750::?979=6:680:48<;995:57734&1135,33+20*,%4<;<408-<:7<0:3780678(;5>;;718;7274589772943+7/<86<4:>867#-3;<9376<+2+8*5:7/919:9=976169)7;8)2'00:48<7930'909637=/623.6:1:2568:96=1>4><9=;7<-/>.:0<;55470830;6988=68<>=9==:=8;<2;<77:871;?:=791390255<9)4+610>379)1&59(:;51;*05663-9*20869345/466.66799769898):4231'6-$.76410)65:;471198723275012:4976175:6373223*22+&$(24372/33*,'056(3986+7641'386,4'1.-79&138543*67;86-65:$&9=7):56;797)7:4$*2264%+3%;89<<7843$3965307978;:6'919647;6-;84746;>379(3-3;481'19/;302$8?:?;=87+%3322285=72.8255<;74)/51=?1,012969<6895713/1;;9018275*3/(5&75:680<:7;2<2>40'3=?>.7:6(/94/&%??299;:::9=<24674/;;=6<9448=66/7795948?>98=%084+2970?9::08=44;279;8.<7;=4=185(;5:0373:<0161(/(7<188.00734;/:;5:+3:54=?869<5'86:-=>7;008;8+9=:/9928?8634857)51(039<;.;>;5/%595;7?;69?99==7>:;4<7754.97>;74:/41)2127)/5109.9=;5*4255$54:7388594-1957:6986874:7?;86.*;.&331,7:97/2-0033-885593:61662533601**&100830"$,)-262.2*8%--8265%).)%+/+(-5-3.2.168*767;59?<323%223413183633:52'340-23/(323;;39,7>8;88'7/16;==.;095?<=:;>:74-8,388:1267=?0578&,8498+24+49<=69;;<8<19+9713.9322)97=;49:;*59::<395<==<5.51+-4;??2=98:<,7=7)1&46-56?=>1=64:6.*0988<5.;<+661-989146/231/61/29645054511+/62,0/**21:5,*'2&%#&&(599934:A7<=7@:@65A:6935<6>?>,9>%>3;>;C;@@+@CAC8>C=A7791;>:46:1:9<0<<-+8$@:B@>AA5BC@2;);22/5-&=*A5963<:C@;:2<75'2596<<@/==5?A<948'>:;8B>BAC6AA6B1?>+<(;/8>/@?>%A=9?.@?>8?>CA?>7B??B6?.8=482=5;C4@=:>=/><5,:&5;-96>>8%79==A>@)23,,#5:6:02;?44/&?7>5<<3;;'2A9:>=7@:6443>>=/@>02920;<8%?=;:;3&=?*C?5>-=?'8%?)>=;-8779=?=<=.>70@11679+,*(<&0:<,<;--370=+>/;;@4??B?@B;6'<=*0)99>5@036+8 @rCer/2422/2561_65_CCS ATGGGGGGTCAGGAAGCAGAGAGCAGCAGATACCTGCAAGCCGCAGCCTCCTGTCTGGGAAGCAGCAGAGAGAGGACCGCTTCACCGGAGAAATCCCAGCGCCGCTTCAGATGCTGAAAGCAGAATGCAACGAAGCCCGTTGGCTGGTGAGGCCGCAGAGCAGGGCCAAGGCCGGGCCCTGCCCGGCAAGGACGCCCAAACCCCTCATCGGCCCCTGGGCCCCAGAGCCCACCAGGCTCTCCCGCCGGCCCACCATGACTTCGGAGTCCACGTCACCCCAAGTTGTGCCCCCCTCTCCACTCCCCGAAAGTCCCCAGTCTGGCCCACCTTTCCCCTTCCACAGGGAGGGCAGCAGGGTCTGGGAGCGGGGTGGTGTCCCACCTCGGGACCTACCCAGCCTCTGCCCACCAAGCGGACCAGGACCTAATTCGGCGACAGCCCGGGCCTCAGGCTGGCCCCGTGTTCAAGGGCGTCTGTAAGCAGTTCTCACGCTCACAGGGCCATGGCTTCATCACCCCCGAGAACGGGTCGAGGACATCTTTCGTACATGTGTCTGACATCGAGGGGGGGAGTACGTGCCAGTGGATGGCGATGAGGTGACCTACAAGATGTTGCCCTATCCCGCCCAAGAACCAGAAGTTCCAGGCCGTGGATGCGTGGTGCTCACTCAAGCTGGCCCCCCACACTCCCCACGGAGACGTGGTCTGGCCAGGTCGTGGGCTCCTAGGCTGGGTGGCTCACAGGCCAGCTGGGGCGGGGGTGGGGAGCCACACAGGTGTGAACGGGCAGCAGCCAGCTCCATGCCCCACTGCCCTGGCTGATCAGTCCTTCGGTGGCCTCAGTGTGCACGTCTGTCTGTCTGTCCGTCTGTGCTTGTGGCTGTGAGCGTGTAGCCTCCACCCACCCCATGACCCGTGACTACTGTGCGAGCTGGAAAGGAGGGTGGGTGGAGGGCGAGGCCCACCAGACCTGGCTTTCTCGCTGTCCACTGCCTTTCTCCTCCCCTCCTGCCGCAGACACGCAGGACCCGCTCGCCCTCCTACCCACCATCCCCATGGTGACTGAGCCTCGAGAGCCTGTGCCGGGCTCACTCCCCGGCCTCCGCCCCTGAGCTGTCCCATGTCAGTCCACAGTTCTCTGTGCTACTTACATCTCCCTCCCTTGGCTGAGGTCCCCCGCCACCATCTAGACCCTTCCCTCAGAAGCCTGGCCGGTGGGTGCTTTTGGGGAGGCTTCCCAGCCACTGGCAGGGGAGGAGGGACAAATACAGAGGCACACAGGCCCCTCACTGCTGAAGGCCAGCCTTCCTTCCTGCTCTGCTCTCAGTGCACTAGAGAGGTAGGAAGAGGGGCCTGAGGGCGGAAGGGGTTCGGGGCTCCCACTTCGCCGCGCCAGTCCCTCCTCCTCAGCCTGGCAGTGGCTCTGGGCTCCTTCCCCTGGGGCTGTACTGAGCCAAGCCCAGGGGTTTGCAGAGGGTGGGGGTCCATCTCTCCAGGCTTGGCTGCAGCCCTCCTTTACCCTGACTCACAAGCACTACTGATGCTCTGCGCCACGCCCGGCTGACAGCTGCTGAGGATGCCGCGGATGGGATGGACACACGTCCATCAGGCAGGGCCGGGCCGGGGCACCCACAAGGAAGGCCTCAGCCTGGGAGACTGGCCCTGCGGCCCCCGCGCGTCAAAACCCTCTTCCAAAGCCCTGACAGACCAGCGGCTGAGGTGTGGCTCCTTGCTTTTACCGTGTCCATCCCTGAAGATGTGTGACTGTCGCTGTCACCTGGAGTCCTTTTGGGGCCAAAGATGTGTATGCACTTGGGGTCGTGGCCATTCACTCCCATACAGGGGTGAGAGTGGCCTGGCCACGGGAGGCCAGGAAGGAGGGCCCTGTCTGCCTCCACCTCTGGGCGCAGCCCCTGCCTACCACCCTCCCTTCTAGACAGCACATCGCCTGACTGGGCAGAAGTGGGGCCATGGTTCAAGGGAGGGCCGGCCAGGGGTGGGACCCTTTATGAAACCCAGTCTGTGAGTTAAAACGGGGGGCTCAAATGCCCAGGATGAGGGGATCAGTGACTGTCTAGGAGGATCCCTGGCCTTGTAGGTGCCCCAAGACCCCAGGTAGAGATCAGCCGGGATGCCTGCATCCAACCTTGCCCCAGGGCCCATCACATAAAATCTGGGAGCCCAGAGCTGCTGAGGTATGCTGGTCAGCTCCCCTAAAATGGGCACGGCCCCAGCCTGTCCCATGAGGAACAAAGGCCCCTGGCCCCTTGAGAGAGGGCTTGTTAGTGAGGGATGACTCCTCCTGTAGGGAGGCCACCTTTTAAGGTACCACTATCAGTCAGGATGTGGTGGCATCAGCCCTGGGGCTGCCTGGGTGGCAGGGGGGCAGCAGCTCTCCTCCCCACTCACAGCCTTGCAGTGCCCATTTGGAATTCCTCCAAGACCCCTGGCCACCCAACCCCCCATTCTTCCTAACACTGGCAATAAACCCTCAACT + $$$$$$#!"%%%$"!#$%%%%%#$%%%#$$"#%%$#"$$"%$$%$"$$%%$%%$"#$$#$$$$%%"$#$$$%%%%$$$#"$"!$#$%%#$%%#"#$##$%$$%$%%%%$%%%$$"$%#$%%%$%"$%$%#$#""%%%&&##)%$$$$('))$)'))'%(((&))()''$(#(%()((&((('%#%#'(%)&$$())%))''$%%'&&(%('())''))&&%'%(&'#')$#)(()))'((((#$&&(#"&$')&')'%()(%%%%&(&((((%('(&'$($'''((''''&'#&%()(%'&$&(#)%'#&,-++(*-,-,)'))$#*(&(#*,)'-++%,)(++($(+&&)+)&,-),,($'%&'&'%(&+,+(*$**&*,-*&(+%&&%(&+'$%%+#&)+'',)))+(&&+.*'+$+-*&*++%$.*+(#%'')$%&)#+.**%)()%#'%$###%#+)%)$*)((($()*,(,+.*)'))(',-*-+'&'))+*%)++%&+.+,.)'#''&##(&#,,,.--*+%'#*+.++',(+*+#''%'&),*'(%))-&)*$#%)*))&()#$)%',-+,+)+)'**$&+',(*(&%,+'''('$)+-((,*)+&'-,))()('%$$'%(**'&)$($###&$((*+''&*-*+($*%+-*(&&')'$%('&$(&()$%**)&#+,*'(,-,%*,'$&&',--,,)&',')%&-(-+&%(*#'&+)++,**-,,-+.-,(*%%))'&%+(*'%#'$#%()%&&('%#&')*''%%#%#"*')+%,..+,+-,#&(&%'&&&$'#&*'((&'*')$#&&))(&&-*&))+*),-.+,+')(**'*&#%(,--+$((&+(,'#'*,(,(,))++(,'+*--&$$&*''++),'%&"&+&)++*)+(*,*+&(,*'(,''+$(&&$**+)*,)$+,()(--))+)()%))&%),*(*+$))&('*,$(,-),-,,-.+,(#",)),-,,*,$)&'+,&+,&*$%'''+&)&(#&%'$(**(+)+,&(+,(')+),*,'',))*+&&##%%$)%#&#%)%+&+''&##'&'',&$'%),++*,),---))(+*,&*,)(+(&(('''*''))##*,+&&**''$$%&'((,+)+++)+-.+-)+-*#&+)+--(((+)')'+)+*('($*')'**'&*-*-.)+-))-*$)--,+),-(*+)(',)++,(*(('*&'()'')($((&+()%***((%#,*,&*'+(-)))'))%)&''%'*'$%($(+('#()$#&'(%*',&%)))+++',+-$%'+%%#"&')$)'*(,(,')%,,-+,*()*'))'%)%&&,,&$&+-,+.,--.+*(),)'(&)*%&,')$+,),(+**%,)+.,*(%%**%&%"$####&#&(&'&))+(*($%'&&(,'*$%,++,,%($%'',+((((&%&$(&&$%$%%"&')&(#"###(#*&+(-%+(--')-%,-%#%+'%&&*+)%%,'#&*+*))&)&$',&+,,&+$,*(+%,(*,)&+'"',*&(%*,'(%)((%*',-(+++()((----)#'+*)),()-)+*)--'(*(,,'&(''-$#&'"%%%%"%',)*('&*-('(*-,--.)*#),%'(%)#&'**((&&''*+,,(-,,'+$*%&'),+*'((#',,**)&(+&&&',*)*-)(%$'(',,((&#$+))()&(#&,')',%%()(+)-,%$',.+&(&$*())$*($%$#+'(('*,%'(&$&$&-*+(,+((',+')+(((+(&((++)--)-+*()(,-)((*-))*((,+$(%())%,-+&,)))))*---++*'$#&,,+%,()*$+*(#,.+)%$&&*,-$)((#(',,((+(%(*#"##'%&++,+,,$'"%'+-,*)'#%)+**)-*))'(-+---..+*-*(#&)+%,&&'+*+(()#'+&+*,)*,'*(,,(+),%))*,%+,',,..+--,.-*+*-('&%$(+*,'*,&,-'(+-)-*(&,%++,-(++-&*-)*))$+-*,.*)*$++--')'+,,,%-*'(---,-+(),)-,$,---(),(((&',,,'&%%)(+(',-,-'%)(%)'),),.--*(*#'&&'#+++),*,*-,,*+()#&*$++,+)'',-,.+,)*,(,-)--+&&,(+',(,&(+--#(*-,.,'()+'(*+))($(*%**$*,--(+-+-*%+-+++-**,*+,(,%++-,*('(('')&)$&+)%&%+-++,,$,+.--,$,.')*(+.-.(')*&+'++,',.,+++#,()(+,)+-,&&-+,,(%**,,--(,-((+-.-,.(,+++-,,*-,*%(+*--)'-,)*+(,)--+(,)---,-*(---*)+,,))(%#*,**,*-.-+(+-.,'&(&'))+)+,++,#+,-*,*'$('-+++*,%',(*),*$'&,)((+*,+,.,*&+%-'-+,(,,*+$)'$(,+-',.,.)*-,**%*,'+-()--+.'--+*$#+-+-+*-+-&$$%%&+-+)-, @rCer/2424/25_3385_CCS ATGGGCGGCAGAGTGAAGAGAAGAGCCGTCAGCTGGCCGAGTGGTTGGACGACGCCAAGCAGAAGCTGCAGCAGACGCTGCAGAAGGCGGAGACTTTGCCGAGATAGAGGCGCAGCTAGCGCAGCGCGTGGCGGCACTCAACAAGGCTGAGGAACGTCATGGGAATTTCGAGGAGCGGCTTCGGCAGCTGGAGGCCCAACTGGAAGAGAAGAATCAAGAGCTGCAACGGGCCCGACAGCGGGAGAAGATGAACGATGACCACAATAAGCGGCTGTCCGAGACGGTGGACAAGCTGCTGAGCGAGTCCAACGAGCGCTTACAGCTTCACCTCAAGGAGCGCATGGGAGCGCTGGAGGAGAAGAACTCCCTGAGCGAGGAGATAGCCAACATGAAGAAGCTTCAGGATGAGCTGCTGCTAAACAAGGAGCAGCTCTGGCGGAAATGGAGCGAATGCAGATGGAGATCGACCAGCTGCGGGGGAGGCCACCATCCTCCTACTCCAGGTCTCTTCCTGGCAGTGCCCTGGAGCTCCGTTACTCTCTCAGGCACCACATTACCTTCTGGTGCCCACCTGGATCCCTATGTGGCTGGCAGTGGTCGGGCAGGCAAGAGGGGCCGCTGGTCGGGGGTCAAGGAGGAGCCCTCCAAGGATTGGGAGCGGTCTGCCCTGCGGGCTCCATACCACCCCCATTCCCTGGGGAGCTGGACGGCTCAGATGAGGAGGAGGCAGAGGGGATGTTTGGGGCTGAGCTGCTGTCCCCCAGTGGGCAGGCTGATGTGCAGACGCTGGCCATCATGCTTCAGGAGCAGCTGGAGGCCATCAACAAGGAGATCAAGCTGATCCAAGAGGAGAAGGAGACAACAGAACAGAGGGCAGAGGAGCTGGAGAGCCGGGTGTCCAGCTCTGGCTTGGACTCGTTGGGCCGCTACCGCAGCAGCTGCTCCCTGCCCCCCTCCCTCACCACCTCTACCCTTGCCAGCCCCTCCCCTCCCAGCTCTGGCCACTCAACTCCCCGCCTGGCACCCCCTAGCCCTGCCCGTGAGGGCACCGACAAGGCTAATCATGTTCCTAAGGAGGAAGCTGGAGCTCCACGAGGGGAGGGGCCGGCCATCCCAGGAGACACCCCACCACCCACTCCCCGCTCTGCCCGTCTTGAAAGAATGACCCAGGCCTTGGCACTGCAGGCAGGGTCCCTGGAAGATGGGGGACCCTCACGGGGAAGTGAGGGCACCCCAGACTCCCTACACAAAGCCCCCAAGAAGAAGAGCATCAAGTCATCCATAGGCCGTCTCTTTGGCAAGAAAGAGAAGGGACGAATGGGACCCCCAGGCCGGGACAGCTCTTCTCTGGCTGGAACACCCTCAGATGAGACACTGGCCACTGACCCTCTGGACTAGCCAAGCTGACAGGCCCAGGAGACAAGGACCGAAGGAACAAGAGGAAGCATGAACTCCTGGAGGAGGCCTGCCGCCAGGGCCTGCCTTTTGCTGCCTGGGACGGGCCCCACCGTGGTGTCCTGGCTGGAGCTGTGGGTAGGCATGCCTGCCTGGTACGTGGCCGCCTGCCGGGCCAATGTCAAGAGCGGTGCCATCATGGCCAACCTGTCAGACACAGAGATCCAGCGCGAGATCGGCATCAGCAACCCGCTGCACAGACTTAAGCTTCGCCTCGCCATCCAGGAGATGGTCTCGCTCACCTCGCCCTCGGCCCCCGCCTCCTCTCGCACTTCCACAGGAAACGTGTGGATGACACACGAGGAGATGGAGTCCCTTACAGCCACGACCAAGCCCGAGACCAAGGAGATCAGCTGGGAGCAGATCCTGGCATATGGCGACATGAACCACGAGTGGGTGGGAACGACTGGCTGCCCAGCCTGGGGCTGCCGCCAATACCTGCAGCTACTTCATGGAGTCGCTGGTGGATGCCCGAATGTTAGATCACCTTAACAAGAAGGAGCTCCGGGGCCAACTCAAGATGGTGGACAGCTTTCACAGGGTGAGTCTACATTATGGGATTATGTGCCTGAAACGGCTCAAACTATGACCGGAAGGACCTGGAGCGGAGGCGGGAAGAAAGTCAGACCCAGATCCGAGACGTGATGGTGTGGTCCAATGAGCGGGTCATGGGTTGGGTGTCCGGGCTGGGCCTGAAAGAATTTGCCACGAACCTCACGGAGAGCGGGGTACACGGGGCACTGCTCGCCCTGGACGAGACCTTCGACTACTCCGACCTGGCCTTGCTCCTGCAGATCCCCACGCAGAATGCACAGGCCCGGCAGCTCCTGGAGAAGGAATTCAGCACCTTATCTCCTTAGGCACAGACAGGCGGCTGGACGAGGACAGCGCCAAGTCTTTCAGCCGCTCCCCATCCTGGCGGAAGATGTTCCGGGAGAAGGACCTCCGAGGCGTAACTCCCGACTCAGCTGAGATGTTGCCCCCCAACTTTCGTTCGGCTGCAGCGGGAGCCCTGGGCTCTCCGGGGCTCCCTCTCCGCAAGCTGCAGCCAGAAGGCCAGACTTCTGGGAGTTCCCGGGCAGACGGCGTTTCGGTCCGGACCTATTCCTGCTAGTGCAGGCCTCCAGGTGACCTCACTCGGACGGAAGAATCTTCCCGAGGCTGGGCTGTTCCCTCTCCTGCCTGGACTGTGGCCTCGCCGGGAGAGCGGGCGGGGGAACTCGCGCCTAGGACTGGACCATCTGTACAGACCAGCGGGAGTGCGCGCGCCCGCCTCGCACAGGGGCCTGGACCAAACCACATGAACTGGACTGAGAGGGGGAAGAAGCGGGCAGGAAGAAATCCCGCCCCAAACGTCCGCCTTCCTTTTCTCTACTTTGTAATTTATTGATCAGTTTCTGTTGGGAGACGGGTGTCCTTTACCCGCGGGAAGGGGGCGGGGCTTCCCTTCCGGGCCGCATGCGGGGAGAGGCTGCCCCTCCCCTTTTTCCTGCCCAGTTGCGGGGCCCAAGTCTTCCTTCTTCGTCCGAAAGGAGGGGAGGGGAGACTCGCTGCTACAAGCCTCGCCCCCTGTGCCACTCAGCTCCGCCCCGCCGCGTCCGGTCGCCGGTCCCCCGGGTCATCTGCGGGCGGGGTCCCCTCTCCCTCCCCCGTGTCTCGTGTCCCCGGGGCCTCACCGCCCCCCGTGCTGTGGCCGTGTCCGTGCCCCGGGGGTAGGGGGCGCAGAATGGCGCTCCCCCTTCCCCTCTGGCTCCGGGGTTTGCATGGGAGAATCCTCTTTCCACGATGCCGCTGGGCGACGTGGCGTGGGGGCAGGGGGGCAGTGGGGGAGCCCTCGCCCCCAACTCTCGGTCGGCCTCCCCGCCCCAGGCGTCACTCAGTGATCACGGGTAAAGAGAACTGTTT + 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@rCer/2426/1123_52_CCS GGAGACCTGCGTGCGGGAAGCCAGCCTGTGCCCTGTGTCCCCTGGTGGGTGGCACCAGCGCCGGGGGCCGGCCACGGCCCGGTGCCTGGACTGTGCCGATGACTTGTGCCAGACCTGTGCCGACGGGCACCGCTGCACCCGCCAGACCCACACCCACGCGTGGTGGACCTGGTGGGCTACAGGGCGGGATGGTATGAGAGGAGGCCCGGGAGCGCCAGGCCGCCAGTGCCCCAGCACCCCGGGGAGGCACGGCGCTTCCTGTGCAGCCTGCACATTGCTGTGCAGAGAGTGCCGCCTAGACCCCACCTGGACCACCCTGCCTACCTCTGGCTGAGGCTGTGCGTGCCGGAGGCCGGGCCTGGAGGAGCTGCTGGCCGGTTGGACAGTAACCTGGTGGAGCTGGAGCGGCGCGGAGGTGGAGAAGGAGGCGCTGGCCCGGCTGCGGAGCAGGCGGCCCGGGTGGGGACACAGGTAGAGGAGGCGGCTGAGGGCGTCCTCCGGGCCCTGCTGGCCCAGAAAGCAGGAGGTGCTGGGGCAGCTACGAGCCCACGTGGAGCTGCTGAAGAGGCTGCTCGGGGGAGGCTGGCAGAGCTCGAGGGCCGTGAGCAGGTGCCAGGGCGGCAGCCGCCTTCGCCCGCCGGGTACTCAGCCTGGGGCGAAGAGGCGAGATTCTCTCCCTGGAAGGGCAATTGCGCAGCGGCTCCGGCAGCTGCAGGGCTGCCCCTGGCACCGGGGCCGGCCCCTGCCTGCTCCCGCAGCTGGAAGCTCCATCCTGGGCTGCTGGACAAGAACTGCCACCTGCTTCAGCTGTCCTTTGAGGAGCAGCAGCCCCAGAAGGATGTGGGAAAGACGGAGCTGGTACCCAGGGAGGTGAGGAGAGCCAGAGCAGGAGAGAGGATGCACCGAAGACGGAGAGACAGGGTGGGGTCCAACCCCAGGCCAGAGATGGAGCCCAGACCCCCAAAGAGGAAAAAGCCCAGACAACCCGAGAAGACGGAGTCCAGACCTTGGAGGAGGACAGGGCCCAGATATCCCCACGAGATGGAGGACCCCAGCCCACAGGGGTGGCAG 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rCer/2429/1715_44_CCS ATGGGGAGCCGGCGTCTAGGCGGCGCGCGGGAACGACGGCGGCCATGGCGGCCTCGGGGCCGGGTGTCGCAGCTGGTGCTTGTGTCCCGAGGTGCCATCCGCCACCTTCTTCACTGCGCTGCTCTCGCTGCTGGTTTCGGGCCTCGTCTGTTCCTGCTGCAGCGCCCTGGCGCCCTCCGGACTCACGCTGAAGTCCGAGGCCCTGCGCAACTGGCAAGTTTACAGGCTGGTAACCTACATCTTTGTCTACGAGAATCCATCTCCTGCTCTGTGGCGCTTCATCATCTGGCGCTTTGCTGGCAATTTCGAGAGAACCGTGGGCACCGTCCGCCACTGCTTCTTCACCGTGATCTTCGCATCTTCTCTGCTATCATCTTCCTGTCATTCGAGGCTGTGTCATCACTGTCGAAGCTGGGAGAAGTGGAGGATGCCAGAGGTTTCACCCAGTGGCCTTTGCATGCTAGGAGTCACCACCGTCCGTTCTCGGATGAGGCGGGCCTGGTGTTTGGCATGGTTGTGCCTCAGTCTGGTTCCATGGCTGCTGCTGGGCGCCTCGTGGCTCATTCCCCAGACTCTTTCCTCAGTAATGTCTGTGGGCTGTCCATCGGGCTGGCTTATGGCCTCACATACTGCTATTCCATCGACCTCTCAGAGCGAGTGGCGCTGAAGCTCGATCAGACCTTCCCTTCAGCCTGATGAGGAGGATATCCGTGTTCAAGTATGTCTCAGGGTCTTCAGCCGAAAGGAGGGCAGCCCAGAGCCGGAAGCTGACCCGGTGCCCGGCTCCTACCCACACGAGCTGCCACCCTCATCTGTCCCCAACCACCCTGTGTCCCAGACGCAGCACGCAGTGGTCAGAAGCTGGCCTCCTGGCCTCCTGCACCCCGGGCACATGCCCACCTTGCCTCCGTACCAGCCTGCCTCTGGCCTGTGCTATGTGCAGAACCACTTTGGTCCAAACCCCACCTCCTCCAGTGTCTACCCGGCTTCTGCAGGCACCTCCCTGGGTGTCCAGCCCCCACCCCTGTGAACAGCCTGGCACAGTGTATTCTGGGGCCTTGGGCACTCCGGGGCTGCAGGCTCCAAGGAGTCCTCCAGGGTCCCCATGCCCTGAGAGAATTGCTAGGGAAGTCATCTCACTTGGCTTCTGAAGGTCCTCCTTAAGATTCTCCTGAAGAAGTTATTTATTGAACACCTCTATGTGCCAGGCTCTGTGTTGGGTACTTTGATCAGTGTCCCTGTTTCAGTCTCATCTGCACTCACGGCAGCCTGTGGAGTACAGTGTACTGGCCCAACTTAGATGCAGAAAGCGAGACGTTCTGCCATCACAAAGTCACGTGGCTCTTCGGTGACACAGACAAGACTCCTCGCCAAGGAACTCGTGGCAGAAGAGGGCAGCGGTTGGCAGTGGCTGCCGATGTCTGTCCCAGCCCCACCGTTCCTCCCTGTGGCTATGCCGTGCTCGTGGTTACAGTGTCCTTGTGTCCGTGCGTCTGCCCTTCAGGAGCTCACAGCTGGTGTGCTTGGTGGTCCCAGGCCTGTGTAGTGTCTCTCCCCTGCCGCGGTCGCCCCACCCGATTCCTCTCCCCAGAAGCGGTGGGACGGGCCCCCGTGAACTGCAGCAGCATGCTGAGGGGTCCGTGTTGTCTGCCTTTGTATAAAGAAACAGTC 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@rCer/2432/1651_56_CCS ATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCTCTATGAGCAGCCACAGTAATAGTAGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGAT + BFDDHCJIJCB:FDI4B1IDIJKDJAHGK?FKJBIGJEE3HDGIBEFFHIJDDEGEGFHIFG8A@HIKFG8J?KCJKII=KIJDJKKID%7C0FIIJ2GDJJ<;C1KJKJH;GJAADH4HHJI,F;BJ;@F:+B@BDEIJE2B>7D=J:ICKEFC=(9>9&BA7;A4EKI=F?E>C57JIE:E8EH2?KGKDGKFFKGDDJHIIIJIJE8CIK@DHJH>FCFJIKK?>IJGGGDG=78?>*J@IDGIJ;GIHD>F?JDFGJ?CII8A9GFF?GJIKK8JHGEE@?AKKIIFHC9=F>8H9I2ACG@KBDCJDGDGDA=4FHH?EA3@CBH=HCG??+FB/=>A?<@7<89.<*>;F=A9.AC;7'>D9DBKFHK3GA;C1GGFAKJE3?JKJI>IJJIKJDCKGKJKJDFIIA0BHDH@@F;CHJJIKKHFFB>AIAKCGGHF25@E1,;)HA?CK=@:KCCAJIEFFH>JBBIJ?IHCKEEBAJIFFCFI6@IA;91&IH/>?CFJCJJAKIJFB4@@CHIH5JD9AFK@GC(AK@JK5JJ>KGBIDAC6FIIHDJHJHHBCA5HCIJHHK=KDE;1JAEHJIHFG=KCJKDGEJDCBAJCEJI6FJDHAD>CFDI?>9(C8738@?JKJKKJAHKCE)FKKGHC@>IB5DFFAJFGGIJK=GHKBJCEGBE2HKKIG28A5KIKJIFE;KAGB@IEJD@HHKK6IJKKJKKECB=;B>?D9B<9EJDKJJJG7>E3DKDDHJKGBIHJKE(B4A=BJKKDBJFJ5GIJEDA;HA@=F6FDCHK:CHA)?D?BG+C@=:+9/FBBDKI0CEIIAJ7HFJKCBGHIGEGGKF@C>@K=IGCGEEDF;:KGJIKI=IJGI?HJDIAADKH@JI@FKIHKKKIJ7BKKBKIFJAJKJJIG9EDJ=KKHIGJK5GA(JIDB@I7BDIHBGJGCBFGH5KK?>IJGICJCA<>+IGFEKEIHJKGCJIIGIKJ>IDHJ2JB>24K59)KKJKFEKJKEHJBJ:II@5@K@KGBFJJ@>F-HFFCHJCDKJJDK?F3C:EH=FGC:JAI6IAHJ7HG6J>KHIH?EDFFKJJKIBIKKKIHFIJ:H=J3JHHKIJDIJHK>JJ @rCer/2433/25_2273_CCS ATGGGGCTGGCCGCAGTCTGACAGAACGGGACGGAGCCAAGATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTCCGCAACGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAGCTGTCCACCATCGCCTTGGCCCTTGGGGTCGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAGATACCATCTATGATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTTCACTACCTGGTGGGAGGCCCAGAGTATGTGCACTGCCTGCTGCCACCCCTGGAGTCGCTGGCCACAGTGGAGGAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGGCCATCTCACACGAGCACTCGCCCTCTGACCTGGAGGCACACTTTGTGCCGCTGGTGAAGCGGCTGGCGGGCGGCGACTGGTTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCTCCGTCTGCTACCCCGAGTGTCCAGTGCTGTCAAGGCGGAACTTCGACAGTACTTCCGGAACCTGTGCTCAGATGACACCCCCATGGTGCGGCGGGCCGCAGCCTCCAAGCTGGGGGAGTTTGCCAAGGTGCTGGAGCTGGACAACGTCAAGAGTGAGATCATCCCCATGTTCTCCAACCTGGCCTCTGACGAGCAGGACTCGGTGCGGCTGCTGGCGGTGGAGGCGTGCGTGAACATTGCTCAGCTCCTACCCCAGGAGGATCTGGAGGCCCTGGTGATGCCCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGCTACATGGTGGCCGACAAGTTCACAGAGCTCCAGAAAGCAGTGGGGCCTGAGATCACCAAGACAGACCTGGTCCCGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCCGCAGCCTCCCACAAGGTCAAAGAGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAATGTGATCATGTCCCAGATCTTGCCCTGCATCAAGGAGCTGGTGTCCGACGCCAACCAACATGTCAAGTCAGCCCTGGCCTCGGTCATCATGGGCCTCTCTCCCATCTTGGGCAAAGACAACACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAGTGCCCTGAGGTACGGCTGAACATCATCTCCAACCTGGACTGTGTGAATGAGGTGATTGGCATCCGGCAGCTGTCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAAGTGGCGGGTGCGGCTGGCCATCATTGAGTACATGCCCCTGCTGGCTGGACAGCTGGGAGTGGAGTTCTTTGATGAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCATGTATATGCCATCCGCGAAGCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGTTTGGGAAGGAGTGGGCCCATGCCACGATCATTCCCAAGGTCTTGGCCATGTCCGGAGACCCTAACTACCTGCACCGCATGACCACGCTCTTCTGCATCAATGTGCTGTCTGAGGTCTGTGGGCAAGACATCACCACCAAGCACATGCTGCCCACGGTTCTGCGTATGGCTGGGGACCCGGTGGCCAATGTCCGCTTCAATGTGGCCAAGTCTCTGCAGAAGATAGGGCCCATCCTGGACAACAGCACCCTGCAGAGTGAAGTCAAGCCCATCCTAGAGAAGCTGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAGGAGGCTCTGACTGTTCTGTCTCTCGCCTGATGCTGGAAGAGGAGCAAACACTGGCCTCTAGTGTCCACCTCCAACCCCCACAAGTCCCTCTTTGGAGAGACACTGGGGGGCCTTTGGCTGTCACTCCCTGTGCATGGTCTGACCCCAGGCCCCTTCCCCCAGTACGGTTCCTCCTCTCCCAGCCTGGGAAGATGTCTCACTGTCCACTTCCCAGTGGGCTGGGGAGCACGGGGTTGGACAGGACAGCGACCCTGGGAGAAAGGGGCTACTCTGCCCACGTCGGGGAGAGATGTGAGCATCCCGGGTCACTGGATCCTGCTGCTGTAATGGGAACCCCTCCCCCATTTACTTCTCCACCTCCCGTCCTTCCCCTCATTGGTTTTTTTTGTGTGTGTCAACTGTGCCATTTTTATTTTATTCCTTTTATTTTCCCCCTTTTCACAGAGAAATAAAGGTCTAGAAGTAGTCAG + E?*JIICHDK?IIJJHIJKKHID%?IK1KKKKIJJHCJFGGIGDIJ8KKDJGKIHABFD@HIE>JKKKB@KFG,EHKIKKJIDIFKI7DJHJHEJF?IFJIKJHKKCHHFGKKHGKHEF?GHDJ>JFDCJIH@JEFJCGH8GCK?K?HHJIKKHJC;JCI7J/KKFKEGDKFDHGD<:FGE;IDI@HD6FK>JIDKGDK5?GACIEGJ4JFFGEJFKK4J3D2FC=A?>(;E7JG=IJF6K(IG@;=GG>DHIGJEJ@F-JKJJGI;I:9C>FACJJFIEICFFKEH?ADHEEJKIJKHGJCGEIKKIJDJJJKDJHIGJJJHJGJF:GIBGEKJCFF@KGIEFI;IIFJJKKIE6(DGG@KIJFKJ7GKJ7KII?ECGKFFDKAJJG5JI,KEG@FHGFHAG6D>:FAG3;8=8B>6:CEF?DIICC);9DDCBFHG>J=CEIHDECG>H@CD@JCIIGJGB=C9F7@C=IEJ>IBIEHFD@DFD?DIF@HEE@3EBIIC99DDFGDHH9HEACIIEGFFEAI@IIAB0JFEFAH@IHHCIIF6GAJC>DGCGHDG=FDBFGIIFGF?G:;CCIF@EH?HGII2ID?BGFAEGC=EBAHFFHEDH>GEIFJFGI>BACC??EIGGEIIGGBJEHBIJIHA9<9DHFDG=GA<6AGIHHDJDAHBHGJ@<4H:B=GBGI;GFCBE?H@CG2GCIICG;DB9B:JGIBEGIEDFG?B<>BFIIE*D9;30??=DH=HHHHIEDH8D=DHBBBEGFG=;AEGB@0A:GDFEBHGHHHE3F9?@JIIGIGAFI=GJHDKJ/KKIIE:K,JJ>EBCJHKIFJJK9FAC?A7AIAKHHFDFKCEJ;FHAIDGA?F>FECECA2IGGIIKIJ>HJHJKFKIFGCG@IKHH=B,JIFGHKHAKFGJK/EDH5JIKIK@KCI?AHBKJE>KJ+G<8CG4GEG>DF7BJIDAGIHFFHBKIJGHHFJJADIKKIKIEI:JFHJJFIC@&BF5AGEGJKKI=IGI@IKJEIJCDJ%C9:I9E8FDIDJ=JGHFHGFFIGDC?HJFDKFDIFIIFG?DIFB:H?4HCJE?G@FBJJIHKJEKCE=IJBIFCFJGFIIJG8=IIDJ5KHEDIFHHEJH)DBEICKKKFGK>FH:GFGHI;H@HI'>EAKJJJDJ=JACC4E?CDGHCKIAD-KAK=HBBHIHKKJFHCKJAGE5DE?CIJFDEJHJI<3ADBJF?HJGJHHAIIJCIIKGEHDKH0HF@HIIHA?DJEFHAHKE:EJI;FFIKHJJ2JIFFJHJ?EI3ID9EKDIKI2KGB8HFB@CEBCF6>C?.BGBJDJ=FIDJI>=FDJGC @rCer/2439/2184_60_CCS ATGGGGGGCGGAGCCAAGACGGTCGGGGCTACTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGTCTACACAGTAGGAACTCATGTCGTTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTGGAGAGCAGCTCCGGTGACACTCGGAGAAAAACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTACTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCGAGGTACAAACCAACGGGAGAGTATGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGGTGAGCTGCATGTCTCCAAACTCTTCAACCATCCTAATATTGTGCCATATCGAGCCACTTTTATTGCAGACAATGAGCTGTGGGTTGTCACATCATTCATGGCATATGGTTCTGCAAAGGATCTCATCTGTACACACTTCATGGATGGCATGAATGAGCTGGCGATCGCTTACATTCTGCAGGGGGTCCTGAAGGCCCTCGACTACATCCACCACATGGGCTATGTACACAGGAGTGTCAAAGCCAGCCACATCCTGATCTCTCTGGATGGGAAGGTCTACCTGTCTGGTTTGCGCAGCAACCTCAGCATGATAAGCCATGGGCAGCGGCAGCGAGTGGTCCACGATTTTCCAAAGTACAGTGTCAAGGTTCTGCCGTGGCTCAGCCCCGAGGTCCTCCAGCAGAATCTCCAGGGTTATGATGCCAAATCTGACATCTACAGTGTGGGAATCACAGCCTGTGAACTGGCAAACGGCCACGTCCCCTTTAAGGATATGCCTGCCACCCAGATGCTGCTAGAGAAACTAAACGGCACAGTGCCCTGCCTGTTGGATACCAGCACCATCCCTGCCGAGGAGCTGACCATGAGCCCTTCGCGCTCAGTGGCCAACTCAGGCCTGAGTGACAGCCTGACCACCAGCACCCCACGGCCCTCCAATGGCGACTCGCCTTCCCACCCCTACCACCGAACCTTCTCCCCCTACTTCCACCACTTTGTGGAGCAGTGCCTTCAGCGCAACCCGGATGCCAGGCCCAGTGCCAGCACCCTCCTGAACCACTCTTTCTTCAAGCAGATCAAGCGACGTGCCTCAGAGGCTTTGCCTGAATTGCTTCGTCCTGTCACCCCCATCACCAATTTTGAGAGCAGCCAGTCTCAGGACCATAGTGGAATCTTTGGCCTGGTAACAAACCTGGAAGAGCTGGAGGTGGATGATTGGGAGTTCTGAGCCTCTGCAAACTGTGCGCATTCTCCAGCCAGGGACGCAGAACCTTCCTGAGGGCTGGCCACATTCCCGCCCTCCTGGGCAGATTGGGTAGAAAGGACATTCTTCCAGGAAAGTTGGCTGCTGACTGATTGGGAAAGAAATCCTGGAGAGACACTTCACTGCTCCAAGGCTTTTGGGACACAAGGAAATCTCAACAAGCAGGGATCAAGAGGGTCCAAAGCCGACATTCCCAGTCCTATGAGCTCAGGTGACCTCCTCTACAGAAGGAAGAGATGCTGCTCTAGCTCTGGGAGCCGAATTCCAAGCCCAGGGTTTGACTTCTTAACCCTGAGGACCGCCACCTCTTCCCAATGCTTGCGACCAGCCTCATTCTACTTAACTTTGCTCTCAGATCCTATAGGTCAGTGAAAGGGCAAGTAGTAAGCTACCTGCCTCCCTTCCCCTAGACCTCTCCCTCATAATTCCAGAGAAGGGTATTTCTGTCTGTTTAAGCACGGACTAAGGCTGGGACAGTCCATCCTTATCCCTTTTCTGGCTTGGGCCCTGACACCTAAGTCTTTCCCACGGTTTATGTGTGTGCCTCATTCCTTTCCCACCAAGAATCTATCTTAGCACCTCCTGCCAGCTGCCCTGGTGCTTTCTCCAAGGGCCATCAGTGTCTTGCCTAGCTTGAGGGCTTAAGTCCTTATGCTGTGTTAGTTTCGTTATCAGAACAAATTAAAATTTCCAGAGACCC 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@rCer/2440/25_2240_CCS ATGGGGCTCGCGCGCTTGGGTCTCTCCCCGTCTCGTCTCTCGATTTCTCCTGGGGGCGGGGAGGGGGGTCTCCAAAAACCGCGGCGGCGACGGCGGCTCCTGAGCCGCTCCAGGCGCCCGTTCCGGAGTCGGGGGGAGGCCCAGCCGGGAGGGGGGAAGGGGGGAGTCTTAGTCATTTTCCCGCTCCAGCTGCTCCCGCCCGAGCGCGCACTCACGGCCGCTCTCCCTCCTCGCTCCGCAGCCGCGGCCCTGGAGCCGCGGCCCGGCCCCCGGCCGCCTCGGGCCGCTGCTCTGCTGCTGCTCACCGCGTCCTGCGCCTGTCAGGAGTGTTGGGTGAGGAGGAGTTGCAGGTGATTCAGCCTGAGAAGTCCGTGTCCGTCGCAGCTGGAGACTCGGCCACTCTGAACTGCACTGTGACCTCCCTGATCCCTGTGGGGCCCATCCAGTGGTTCAGAGGAGCTGGACCAGGCCGGGAATTGATCTACCATCAAAAGGAAGGCCACTTTCCCGGGTAACATCTGTTTCAGAGTCCACAAAGAGAAACAACATGGACTTTTCCATCCACATCAGTAACATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCGGAAAGGGAGCCCCGACGTGGAGGTGAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGTGCCAAACCCTCTGCCCCTGTGGTATCGGCCCCGCAGTGAGGGCCACAGCTGAGCACACAGTGAGCTTCACCTGCGAGTCCCACGGCTTCTCTCCCAGAGACATCACCCTGAAATGGTTCAAAATGGGAACGAGCTCTCAGACTTCCAGACCAACGTGGACCCCGCAGGAAAGAGCGTGTCCTACAGCATCCGCAGCACAGCCAGGGTGGTGCTGACCCGCAGAGACGTTCACTCTCAAGTCATCTGCGAGGTGGCCCACGTCACCTTGCAGGGGACCCTCTTCGTGGGACTGCCAACTTGTCTGAGGCCATCTAGTTCCACCCTCTTGGAGGTTACTCAACAGTCCATGAGGGCAGACAACCAGGTGAATGTCACCTGCCAGGTGACGAAGTTCTACCCCCAGAGACTACAGCTGACCTGTTGGAGAACGGAAACGTGTCCCGGACAGAAATGGCCTCAGCCCTTCCAGAGAACAAGGATGGCACCTATAACGGACGAGCTGGCTCCTGGTGAATGTGTCTGCCCATAGGGATGATGTGAGCTCACCTGCAGGTGGAGCATGACGGGCAGCCAGCGGTGAACAAAAGCTTTTCCGTGAAGGTCTCAGCCACCCGAAGGAGCAGGGCTCAAATACCGCCGCTGAGAATACTGGAACTAATGAACGGAACATCTATATTGTGGTGGGCGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGCAGCCCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCCTCTACAAGGTTGCATGAGCCTGAGAAGAATGCCAGAGAAATAACCCAGGTACAATCCTTGGACACAAATGATATCACATATGCAGACCTGAACCTGCCAAGGGGAAGAAGCCCGCTCCCCGGGCCGCAGAGCCAACAACCACACAGAGTATGCCAGCATTCAGACCAGCCCGCAGCCGCATCGGAGGACACCTCACCTACGCTGACCTGGACATGGTCCACCTCAACCGAACCCCCAAGCAGCCGGCCCCAAGCCCGAGCCATCCTTCTCAGAGTATGCCAGCGTCCAGGTCCCGAGGAAGTGAATGGACCGTGGTTTGCTCTAGCACCCATCTCCACGTGCTTTCTTGTCCCACAGGGAGCCGCCGTGATGAGCACAGCCAACCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACCCAGGGGCCAGGGTGCTCTTCTCTCCCCACCCTTCTTGGCTCTCCAGCACTTCCTGGGCAGCCACGGCCCCTCCCCCACATTGCCACACACCTGGAGGCTGATGGTGCCAAACCAGCCAGGGAACCGACCTGGGAAGTGGCCAGAACTGCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCACGTGGGTCTCGAAGACCCTTGACTGCCTCCCCAATGCTCCGAGCCTGAGCTTCCAGGGTGGCCCCCTGACCACCACCACCACCACCCCCACCCAACTGGGGCTTAACGGGGAAGATTTCCCCTTTAGATCAAACTGCCCCTTCCATGGAAAAGCT + 25,53:189885-6544$55916:=48::8..+$1.027238=5??9/*85&8=<<5*4017$1/0353688=/=>>;2:86,<98>946:3*30488876;;=3>;6:6<8+37<8==508+:5;<362+88328.*4)953643'482%546;:/,$8;<<<(.386:>7-9:%58$$779=;;=4-$0209*::8#53;,2<;4==;97327+<6;97569/767'4687/$.:668.+89?:70897+5+13/423492524347488/385:7/73757;+22-81686946=<97247.8>3::97;=250*776)==783==;83<;?<8:<4:4/91+679389=07,<:/93>>><845.;4:6-:;?)8-86<38.81;1(<5(09126:3;=><%:945594=3>::6:=><;27>>293230655*9684:690:8252748:4=652785?8<4/7;>7::8;3830395380420068=:;?<-;.9+7176*70/2%1:::;391.652;==9780209;=:>=:725=9=;898;105554:98=<8/=<)9:93>9.<=:87::;<5=>+>%.46==2;=82)756951:<>9><<94808;486556*69;:714:<;36/7+0/'+)5969;6-886-/48;29910:-69.<;;2:296):9<11;8*566=3709365$6=22/8.38,-48<>>:><,6496;:69/:;9,51<>;66=3;>:99826:=:2897:7/3099=?699>4;281*:86<707<95..3;84*3*9537/4094;==4.469394=>;9;46:4>6949.%7703.;99388?:1%6-/99;26,6027:<2;<90=:>*-%56(95;<8:;>1)36;<::/399/7$4;7=3..?;::18;<:9;>8??4:9:9:3;;/32(==:=;->>99;?/+61,:>2;7976/?/5&374%025,=9:69;299?>;397/778)206:<6::<-;:6291:8//61376.%34277-836(86:(,70065158>.97;3778;<<4;6>9<<49:721594613,598:4;>8.:44$3($69:19)5,262168:9>2=80+8:73:43/&-'-,7:;3'-.89888554<2)4*7298<1675/0264<33::064-<-3=<14'70;<848?<(<<8>:<68:<0*8879159+20,7/1:<=+:=;?:;358>>>65,*<;:2;<1/=:332;7<5905:80)76*28656976304491<9;5>>8?9:;?::>706942<7?:;;A:>=186)<&89@54*/$5.*,/139:;/=<=59647=9B<48<;=;.)3&:%;=>:C9+61%1.71,-4=<.81*@<15;79(=+597>4<-6<<08.749/6-608==4?=6<:'5754=<9854%><7;7>:A5<>8>9&940;@587;80/090B>==04486>20641538-0149,6#1/889<7;6?9?=<'<;52;/3=;:8;8:>903:>85=27)175*:6@@CAB;AC;071,7;=;,138;==997'8<43'4361=;612?=7<>:3?<3,-56<:=?<777?76(090)5@5;.'56=7-1=3569>==A5;/678949+>':;5'1@2:<6=3,<>:22B@4@03;886D;6?=6<3@;=;:924/4/763441/:7639;?0:<68=41542A66/9@A;>?C@C<=?;+=B@=BG0?@<1530;';D<;@19B:915..&<@B:>@>?=DC7C>?>FE?CC=@=@7F@&>>9::6C;5=-96>7>@A:*5)45D@33,)80.4.5>.1C04D8&99>==25*3=;8&;;6A.>-=@3CA=BCFB1DE+.=>@DBAB&75<)>(?@;*><9788'><>>=9):??=??=5<<9>96*.=5279;:>;9>>9>===>8>:=87?=>?;37;86<:>>=6>?>?<<>>6<>6/)/35685=>?5<16875=08::9::09796*3;888*>;<<5589(;>>95=7:=;<<39<:<6==8=/9=:?<=75=89==3=:7???=<;/:;:>?;=>>>:>68;6,2>>=<85?:<=5;>===:=8>78>??<:423965250938=:::::>:;8>;:?>?;<<66:;<===<.:;3=>7:98848%:>::;+;.<==>>>>>>8>A3?=+:A=>=>99A?B?C@B:=:B;A>=>:>:#/;@;6@=>??<=>AA:9.47A9@CA=A@@=C9B>A842>4>6A?C<56?>@6B=?AB>:B=BB=8@>C9C8AA.BC?,@A>6A>9;1:7A:;?B@CA?@0;=>,:3B?C===>B=BBC?0?@>=?@BB1BA;BCA:B>9?4AB<;=;6??;@=CC8A98>697CC=?A=/:==;@4;?*>?>97;??=>6,-1,58<3;1;?8@A3@??>5A@???<@>9@<8?B?/7475==9>=?@3)+>>BA?:-::<=:BB=>=AC6C>?<:=;<=;8;9<<;;CA=;C?CC=>??;=9:CABA>=:9==:BCB>CB=<=;?&49AB>C@@@<;/7B4BAC=BA??<@.@?>;??BC@BC?/<4=?@>@:=6?>?/:@-@=;5+:>5A>>BB:>=;?%@?A=BCAB7B:@2399:?86@<6?@C=BAABA<=?<>==?=>)??C===7B?>A@>A?B=?8:><@*<6?6BC=>=;;>59;:=>B@48AC>=BB;.75?<:B:AC;BBB=1AB@>C@:A9>6=?;<>>>=.ACA@AB=9@>';B?4CB=?<3@B>4<;=CAC/C@AA7BAC;ACCCBC<>B+B;@=>B=:A:A>=@=@;2<;@:=?:????B>96;;66><@<@;@:>;?-BAA?6?<<3'645;??@C@=CB@6>7BA?=A=?B=;=)7<@6>?:3>8<@2>=AB>:=:>@7?@AA>C,ACC@AAA=:5<=:AAAB9@?@6?2>A;A>0<7BACA>BAA???BAA,A828;;C>?4@@97A?7<8:=A=;>>B8<1:6;0:69669:<6;574.9;99>A:164>-259<>91=@@A;:0@?;>;0?<9BA/8==>?4??>=8@@C?><>A?ABC>;=77,.492:6A=?6@A?=:=@A9A:;:9A8A7:7=>B8B;5+4:>2<4C@>0?;?=@CA?=706:@7<=@@<4/)9<6?<3AC?A:=>?5849;9<>*;>?5A@@?A@B@A>>7@==;8B?1?46:;>-;==?@??694=?8=?5?=/9=8A>ACBCCB6A>?<==A>5EGFGBCBBBC@96ABCBE6DFFE=FDCEG;DD2E?D:3DB;=:;:C9FACBD@ECB9??A==7B@;>2C?@5@@:>;D=8=B>8A48GFF?>CDE?C@9BBBGA7F=FGCD:F8DACFAG=@EA?@GB?@D=3D<:A2D>:D;C1;>:/96=0FDBB>77<>>7C7ABDB)=CDGCDDE;EAE@@=@?A?FFE?FGGCBEC7FAGAD>?BFD59<=+@?;?@CB@?3?=(E=>5?@8==2CDEG;>EBCFE?=<7=BEGCA9@C?C>A;DDBB3@@B;D>A*>A@8A?;EAAGBC@9BC;DF4AF9DB@:=<;CBE6=C7G@D+>:D;BEF?EDECCB@GC>GDGGD?B:BE=FDE@=B=GBE9EGD8@@7CECBFBFE>FE@B9=?@?1BFG@EBA=@?:><4?@BBECEB>B/FBED:C:BB?AABAB:?F8EE;H==H?CFFHD:FDF8KKKDKKKKKKKIKCKKCKKKK1KKIKKKKKKKKKK=KKKKKAKKKKKKKKKFKJKKKKKFKK-KKAKKKKKKKIKKKKKKKJK7KK'KKCKKKKKK'KKKKKKKKKKKIKFKCKKKJKKKKK:KKKKJKKKKKGK=IKKKKKKJKDKKKKKKKKKIKKKKKKKKKKJKKKKIKKKKKKKKKKJ@KKKKKGK&KKKKJKKKKKKKHKKHKKKKJKGKKDKKKKKIJKKKKKKKKKKKKKKKFKKKKK?KKKKKK.KKK4KKKKKKHKKKKGKKK.KKKKKKKKKKHKKKKKIKKKKKKKKKKKKKFKKKKKKKKKKKKKKJKKKKEKK*KKKKKKKKKKIKKKJKKIK;KKKJGKKKGKKKK:K-KKKKKKKKKKKKJKKFHKKKKKKKKKK4KKKKKKK8KKKKKKKBKKKKKKK4KKKKK2KJKICKKKKKKKJKKKKBKKJKKKKKKKK2KKK3KKK$KKKKKHKKBK%KKKKK3KKKKKKKKKKKKKGKIKKKKKKKIKK'KKKKKKKJKKK$KKKKKKKKKKKKKBKIDKFKKKKKKIKKKK=KKKKKKKKKKKHKIKKKKKKKKKJKKJKKKJKJKGKKKKKKKKKKKKKKKKAKKKK=KKKKKKKKKKKKKK3KKKK,KKKKKKGKHKKKKKKKKKKKKKKKKKKCKIGKB@KKKKJKKKKKJKKKKKFKKKK'KKKJKKJKK.KKKGKKKKKKCKKKCK7KKKKKKEKKGKKKKKKKKKKKKKKKKKIKK@KKKKKKKJKKFK=K:KEKK9KKKKKKKK?K6GKKKJ&KKKKKKKKJKKKKKK-KK+KKKKKKKKKKKHKKDK&KKKKKCKKKKKKKKKKKKKKKKKKKKKKKKEKKJKKKKKKJKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKJKKDKKKKKKKIKKKKKK*KKKK>KKKKKKKKKKKKIKKKKKEKKKKK@KKKKKKKHKKKGKKKKKKKKKKKKKKKKKIKK;KKKKKKKKKK9=3;:58;4:77=<4616:>3=8;8>:;;<=9;>=6==>4>==165;?:;?3>=;;16=791;.5:7<36<69:4:;*;;8><:.=<:8887;48/:965>99>795>84<9>;?9>>>8=;>>?76>?:8===>9;:;0-7;<>9?78?=9>091,8<<>:;0>=>;=?==;=;89;-96'966=>87>55=9=<=?>5:8;=4;<>:4=<<9529><<1<:=8=<:?:=<4605=-:<5:079><7?>;?=3>:60&=;=::3>955:8>:9<;=:==.9788;6<=6>8;5973:96>=>066-;<96?>9?42/?<<=>8>>A;<<=;84==8A:->;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@rCer/2448/1988_55_CCS ATGGGGAAGTGAAGGTGGAAGCGGCAGCGGCTGCAGCAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGAGCTAAGCTTGGGCTGGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + HDKHJ0I6@IJJEFHJKCK:E7IEKIKB?6KAH<>>DJJCJ>IEJHH@IKFGEGFHIGKJBF=FJJCHJJKJGFCBBGEG@6EHHGHFGEBBCEIJIGHFHKIKAIJJBAGIFBGIFHDB6JJFJKI:DIKBDJGKI>DCK6DJJKJKGJHF$EFIFJGDJGJFDAGDC=JFJIBKHGHEHII>D/KFJHEBDGEJGGKKH4JHDJFGGEIAJIKGDBIKJJKJK;FJKJ6IGCICIFJHK:;>8FKGJIGFIIFJHIFDF(H@JEAGDIFGHDEDJH@;7DC>HDJII8I=K:JGIJHIHJJ;FK;K:KJKBIH@KIEGEKK=IFJGDJJKJ+J@IIF.F6FHEKGHHGIA:AH>GI3J?FKK;AHH*HIJJFKKJ8H5FFJI>@GKII?IKHJFIGDF8E?JHHAKCI0JHIHGDHKEHIKJIIH:KFJCGGIHFJFKIHHHJCFHHEGKGHD;EGEKIBFJJG?EIK9HIBIHHDC<;GAHFA8@K@KGGEJIGGBAC=GIJ0EGDJKJJIHAEHFGJ<@HAJAAIGHHFKKII'HAKJHIIHJHEKHIIAJGKDJGGJK?JIHGBCK8JFIKJKJAHHGFHGABFJIJIIHCKKBKGEIIHAFAHKDGCJHIJJ,@IK6KKKADFFHFDHKH@FK??FHC?EIJIKIBJIHIK4HAJHDJKJ8GA9DHFDG7>BC*JJJJ>IJIKFJKIKE5BCA><@GHGDIKED@KEIGHHII>AKF'E?GGHG6KGICBEGJAEBIEIHFHIEJ4JFHJJDGHII@CEIIDAJCJIHGKKKDIJF/III=G;EEJHJH/BFJIK;CFGH9E??EIFJCI9KJ@?HGHD,EHHKKIJKEJBIIHJBIKJJIIDJFCJHBDGICCIJIJKKJ?JKIJCKCG>FJ@IGHEH8GBGCBE:HHA&EI;JKJJHBDBIJFJ-FECDEBAAB,CI@IK>BDKGIKH)CIGBFII>IJK>HAFB$DEHHDIK@KKFJKAJIFHCEGJKHDJDFKKFBBKFJI=HHAGJCGJJJG@K;JJ>A>IGF9G@?EEJGCKEBHJDJIIGE=FDB&KFCBK=IHKKJIJI>IGC@CICJJCHHHEDEB@@IJHKJJI>D@FF@CFH>GHCJKIF1GGKIJK=I?HC=GG>GHICE=GDF7BH?GHI3IH>H8JIGHHG*K;JFCJ9IHAGIBKDI2IJAIIIDI79CA$F5HFD/GAKKIAIBAFJJ>FIJFIJK=HEJDBBF?BJGHGAHK4IJGGJDH3>A=4C7CC:EA@0>CF18>H;8GAEEECB>FA8FI8A=A1>EIFCIFH?IAD- @rCer/2455/25_1815_CCS ATGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAGTGCACACCTT + II3KF?6BGDC?KHK=D5JHJIKK5KKKKKKIDCKG@?D@;J@IKJKKKHJF7ACJ7K=KJKIIJKJEEGKFKAFJ.JJKKEKKKICHJKGJ(GGJKK4HI;KKKIEK+KDGJKKJKCJH;KKKJK8KKKK@?K0HKIJIGHKKKKKKJKKKGKIAKK>?K8GHFE%FJKKIHDKBDI>?KHK6IKHAJFKKKHJKDKK5GKKHJ@HJEGJ<2IHHIG?EKKFKIKEJ,KKGJFK7?ICIKHHKKKCJKFKKKBKKIG>KAKIGKJKJKKFHKKF??5H@1KKKCKKKE;K?IJK:K=KKKKJKKKJCKIHKH+0(JKKJIIJK7KKKEE8@GKJK=JJ/IKIBKIKJGKCKKJJKIK?HG0KKJKGD>GKKJFJBE/JJKIF>KK>JJJKEF=J=KKJIKKCJIKDIIIKFI4IDIFCK;J>DKAK7KHJKJK:FIC*HKJKAHEGKB-DJIHFB@GHI3KEIIIIE6IKJ5KJFIJ;A=HIJ7K=$E7HEJBKKEBKAKDIFH8KBKKKGCKHKEJ6JDIJBKJKJKAEJKKK6KKIK>DFKFJIJ:IJJJIIEGEK:F:FC1I??FH:KKKJI*KK9KJKKIK>JGKKCAB;KKKJKIKDKJFJKJGJJJ;JHI@:JK:AAKGKJEJ>EA@3KKJKJHKIKIGJFKJKKGKHKKJKKKKJFKKKJKKKAKKKJKKKJKKKJKKKFKIIKKDKKKKKK;KKKKKEKKKKJKKKKBKKJK:KJF;HKKKJK:KJKGAKKKJKKJKKKJ2KKKKKJHKKKJKKKKHCKKKIKKKKJKKKKJJK8KFEEKJKHDBJKJKKKBKJ@KHFGKJJKG8IKIFKJEJAHIKIIJGKKJKK@KKKKIKIKKKKCKKKKKKEC.JJ>K@>J:KJIJJKKKAK6JHKKKKKKKKIIKKKKKKKKKKJKJ7IKKKKKHJJKKKKKKK>KIKJKKKKIIKDKKKKKCKFJIJIKDKDIKK-KKEFJ9JKIIKKIKKDKAKK>KKKJIKJIKIJIKIEFKJ@EKJ:KFKKKKKCKJ=C4JKJHKK1@JJIAK)KKHFFKKF:KGGKKCIFCJKKKJKFJAKJHKIIIK>KIJH7KD8'KJIKKKJJJAKIKHK>KHKKKK4DIJKIH4IKKKJDJJGKKKKKDKKCJKJ+DG)HEDKIIKJIGKJK @rCer/2456/0_2163_CCS TGATACCACTGCTTGGGGACAGCCTCATGGTGGCGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAATCAGTGGCACAAGCCCAGTAGCCAAAAACCAGCATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCAGTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCCTCATACATTTTGGCAATGACTATGAGGACCGTTACTATCGTGAAAACATGTACCGTTACCCCCAACCAAGTGTACTACAGGCCTGTGGATCAGTACAGCAAACCAGAACAACTTTGTGCACGACTGCGTCAATATCACGATTAAGCAGCACACAGTCACCACCACCACCAAAGGGGAGAACTTCACCGAGACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAAGGAATCACAGGCCTATTATCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCCCCGCCTGTGATCCTCCTGATTTCTTTCCTCATCTTCCTGATAGTGGGATGAGAAGGTCTTCCTGTTTTCACCATCTTTCTAATCTTTTTTCCAGGTTGAGGGAGGGAGTATCCATCTGCAGCCCTTTTAGTGGTGGTGTCTCATTCTTGCTTCTCTCTTTGTCCCTGATAGGCTAATCAATACCCTTGGCACTGATGGGCACTGGAAAATATAGAGTAGACCTGAGATGCAGTCAAGCCCCCTTTGATTGAGTTCATCATGGGCCGTTGCTAATGCCGGGCCAGTAAAAAGTATAACAGCAAATAACCATTGGTTAATCTGTACTTATTTTTGGACTTAGTGCAGCAGGTTGAGGCTAAAACAATCTCAGAACAGTCTCAAATACCTTTGCCTGGATACCTCTGGCTCCTTCAGCGGCTAGAGCTCAGTATACTAATGCCCTGTCTTAGCAGAGATTTCATAGCTATTTTAGAGATATTTTCCATTTTAAGAAAACCCAGCAACATTTCTGCCAAGTTTGTTAGGAGGCCGCATGATACTCATTCAAAAAAAAATCCTAGAAATTGTTAGCTCTCGGGACACTGGCTTGGCCCACTGGAGCATGAGCTCTGTATTCTACGGAGAACTGGGGCAATGTTTTACTTTTCACAGTAAGGGCTACACAGCAGCTGTTCATCAAGAGTAAACATCGGTACAACACTAAACCTCTGGCTAGAGGACATATTCACAGTGAACATAACTGTAACATATTGAAAAGGCTTCTGGGACTTCAAATCTAATGTTTGGGAATGGTGCCGTTGGAGGCAACCTCCCGTTTTGTTTAAAAGGACCTATGCGTGGCATTCCTTTCTTTAAACTCTGGGTAATTAAGGCAGCAGAAAAGTAAATTGCCTTCTAGACACTGAAGGCAAATCTCCTTTGTCCATTTACCTAGAAACCAGAATGATTTTGACATACTGGAGAGCTGCAGTTGTGAAAGCACCATCATCATAGAGGATGATGTAATTAAGAAAATGGTCAGTGTGCAAAGAAAAGAACTGCTTGCATTTCTTTATTTCTGTCTCATAATTGTCAAAAACCAGAATTAGGTCAAGTTCATAGCTTCTGTAATTGGCTTTTGAATCAAAGAATATGGAGACAATCTAAAAAATATCTTACGTTGGAGATGACAGAAATATGATTGATTTGAAGTGGAAAAAAGAAATTCTATTAACATTAATTAAAGTAAAATTATTCCCTGAATTGTTTGATATTGTCATCTAGCAGATACGTATTACTTTTCTGCAATGTTATTATTGGCTTGCACTTTGTGAGTATTCTATGTAAAAATATATATGTATATAAAATATATATTGCATAGGACAGATTTAGGAGTTTTGTTTAGAGCAGTTAACATCTGAAGTGTCTAATGCATTAACTTTTGTAAGGTACTGAATACTTAATATGTGGGAAGCCCTTTGCGTGGTCCTTAGGCTTACAATGTGCACTGAATCGTTTTGTATAAGAATCCAAAGTGGACACCATTAACAGGTCTTTGAAATATGCATGTAATTTATATTTTCTATATTTGTAACTTTGCATGTTCTTGTTTGTTGTATAAAAAAGTTATAAATGTTTAATATCTGACTGAAATTAAACAGGAGCGAAGATGAGC + S'%#&(&$*#'*$'/4321511/5'-)0-631.+(/&.-01124/-,20246/,///13220/4622503...-/2463/0--55/312*-/+.'02.4/'1002.#*042664(%0//)',1/01.0-(401.-,5462-,--30.00'$+)-.+40.21&.%%.4./0154423-02004636163.&-1434+03.040+/+46655/.140%,1/**00.1-.0+244/*..*-/3043)0-0011)013)2-+4+-/+2/.$,&$+01,3/2-&-0/,001421554.200-/*.)/+)*(+%++-,/0+4.(0-14402.4/3250514432.,/321,410+..02,+.11145--(2116/561-3/+/)/2*-,))-//0+431321-.*2413$,/3/20./0+5202-/-'/.+1&43664130//10-*-/0141+3*15/'244./'1*114/+**01.//3454/2.03603.52)+.3)4/*0$*')',-./,/2/0'23.15522/+&*05/(0*'(+**042/,**.)3/.00*../43,,)0%.6/1*/#*.50-$**11456210*3320+0*(#,2333120)/.54544/205+3)+142666405140*01%-2022505114*'10154&14.42/*4--$*-06625.401151*)043,+41362,.2+*/+10(44524116/5560++06/'/-*.0,0*.+-//-&**/43%3//+30),32,$/43646541,/-0)-10163120/114)/0//+/&&(12120$-'&.,,,-$&.--/.100+-.5235,)).-.&(*'*25.2-*3253.-05-4,3-+5245.563665/352,55*)%233.400/41*42-/1,65,124,00.%/.1.2+&032../4//12224135+2550354155.4-+,1*/(0/.)1)./3./64-3+314/*,0114535,*$..%&&***.2(-2/014/66,#.*&00/-20,1,(4.326542,-146654650/0.0+,5052030-2024543)04*/.2121443261/4(43/62256565515)4.04540.15,/16.4530+46...+)11240320*-&*0044+/*./21515-623615+431150614-15661)3.210.45-1/2260-/0-3.15311*)00*20020+2/45/2122..%43,3415-111410+532113*02035/41*23//,310+404/4+3$10%010-0-*3,2*0+11501&.0/0/00.,*-556603(./(')*0+021-/11*/-1,&31(#/1')$),$*/0/34/63+46224,3431003)34-226465525+*.-)0024./-0301)+2+3545426616101/3245046540//5-53-/1/1246.54)/1/1.302-/5-$(4656-&%320/*,-5500/50--+1204321025,&-0.2463022,51130,.)/12-0652.1-/.-6-1)4-*/--0-5,231+0'/0-+302/042-4-565*+004%100(340.531-1-+23340.+40-5(5531/4+/)2+.*21*3/5'.41).412140/1)13'-*01%-.-//42/0421-41,/,220-30403+'/+(.054)-'002++126.55/3104.'52.,.+4-221(5,(*14.-1&00*320%114655+//1346150/46.6351$01/(-200*11263-.50,255254/6142633.-+2145*2/453.653'55512134565562452(1(+3-1013/*4//,&-/(+$,-04/(0(0,+*,,+(,1.).210.*+.-*&(.20-)/*5.20+.5521*66/46,*(,0/0,./.*.1511)3.3/2043(+2.-.-1-/53(/1..*-(-2540+*/'3'/135(,/,,+..6132+-(1/+43(0)$--+0-+#-(,(%'*+1%%$/51053/./2.)+,.00(%/034/12.52*//34'5.43/,/1./3.,022.0-656165/)1(-&.441(..-2'1*-,**-/1304/2061$(,6/&)-0,*44+10.--$,*))*&%'(%(-+.*,,-.,...,/%-/,11.0*0)/.)**..&&+21..+/*,//''..&+*-0 @rCer/2457/1887_59_CCS ATGGGGATTCAGTCGGGGCTGAGTGGTTTTCGGATCATGTCTGGTGGCTCGCGGATTATAACAGAGAACATGGGCCCAGAGGGAATGGACCCCGATGGTGTCATCGAGAGCAACTGGAATGAGATTGTTGATACTTTGATGATATGAATTTAAAGGAGTCTCTTCTTCGTGGATCCATGCTTACGGTTTTGAGAAGCCTTCCGCATTCAGCAGAGAGCTATTATTCCCTGTATTAAAGGTATGATGTGATTGCTCAAGCTCAGTCAGTACTGGCAAGACAGCCACATTTGCTATTTCCATCTGCAACGTGGGATTGAGTTCAAGGGACCAAGCACTAAGTATTTGGCCCCCACCAGAGAACTGGCTCAACAGATCCAAAAGGTAATTCTGGCAACTTGGAGACTATATGGGAGCAACTTGTCATGCCTGCATTGGTGGAACAAATGTTCGAAATGAAATGCAAAAAACGCAGCCGAAGCACCACATATTGTTGTTGGACACCTGGAGAGTTTTTTGATATGTAAACAGAGAATCTTCTCCAAAATGGATCAAAATGTTGTTTGGATGAAGCAGATGAAATGTTGGCCGTGGTTTAAGGATCAATCTATGAGATTTTCCAAACAAATACAAGTATTCAGGTTGTGTTGCTTTCTGCCACAATGCCAACTGATGTGTTGGAAGTGACCAAAAATTCAGAGAGATCCAATTCGAATTCTGGGAAAAAGGAAGAATTGACCCTTGAGGAATCAAACAGTTTATATTAATGTTGAGAGAGAGGAATGGAAGTTGGATACACTTGTGACTTGTACGAGACACTGACCATTACGCAAGCTGTTATTTTCTCAATACAAGGCGCAAGTGGACTGGCTGACTGAGAAATGCATCCAGAGACTTCACAGTTTCGCTCTGCATGGTGACATGGACCAGAAGGAGAGAGATGTTATCATGAGGGAATTCCGGTCAGGTCAAGTCGTGTTCTGATCACTACTGATTGTTGGCTCGCGGGATTGATGTGCAACAAGTGTCTTGGTTATAAATTATGATCTACCTACCAATCGTGAAAACATATTCACAGAATTGCAGAGGGGGTCGATTTGGGAGGAAAGGTGTGGCTATAACTTTGTTACTGAAGAAGACAAGAGGATTCTCGTGACATTGAGACTTCTACATACTACAGTGGAGGAGATGCCCATGATGTGGTGACCTTATTTAATTCCTGGGATGAGAGTTTTGGATGCAGTGCTCGCTGTTGCTGAATAGGCGACACACGTGCATTGTGCTTCTTTCTTTGGGAATATTTGAATCTGTCTCAATGCCATAACGGATCAGAAATACAGATTTTTGATAGCAAAGCGACATTAGTCGTGAGCTCTTGTGAGGAAAGTCATTGGCTTTATCCTCTTTAGAGTTAGACTGTTGGGGTGGGTATAAAAGATGGGGTCTGTAAAATCTTTCTTTCTTAGAAATTTATTTCCTAGTTCTGTAGAAATGGTTGTATTAGATGTTCTCTATCATTTAATAATATACTTGTGGACTAAAGATATAAGTGCTGTATAAAATCAGCCAATTATGTTAAACTAGCATATCTGCCTTATTGTGTTTGTCATTACCTGAGTAGAAGGCCTTTAAATTTTTTTAGAAGCATTTGAATGCATTTTGTTTGGTATTGATTTATTCAATAAGTATTTAATTAGTGCTAAGTGTGAACTGGACCCTGTTGCTAAGCCCCAGCAAGCAATCATCCTAGGTAGGGTTTAATCCCAGTAAAATTGCCATATTGCACATGTCTTAATGAAGTTTGAATGTTAAATAAATTGTATATTCACTT + $%%%$"!%#!#"$%%%"""#$#$%%$$%%#$%%#"#$$$&(&%%')(&(&(()((&#$''%''$(()(%(%'#$$'#(&())%%&%)(('&&$$"$)',),*----,),)+,)((-)-($',(&-)+-,*,'#*.*-,(),'"'+)*'&*$--,-)+)+(,',(,.,,*)*$'--)(+*$((+,-(--+)*,)*#%+#('-),#*-)*)*$(')+)&,,),'&)%-.,)*)(*%*+',&(,)+&'$*)&((*)('(&$&'''''%(%&&(',&,-'(')(%+)*)'(&$,,'(--(*'(&$*''-'#&%'$&$,,*+(-,--(-$('*#&(+--+%$&(((&*$-,,-),',*,)+,+-)$++()',*--,)--,*,--&-,,($-),,-)-,&),,-((%%,),,)()($'&,-*,,()*+($(.,,--,-'-'+.)+)),,&,+-)-+,,$&---*',++((,+%$'()$+,,)&()(-++-)-,*%(,)&,#*&'*,.,**'&'%'$"$%'#*%'%&"#%,%(*)#)#*(*)$'(+()++#%)&*&+)**%$&*#*+*&)(%%'-,),--)(',*$%&#"%%-)*),$%,$-)*'%((,$#''('+,(('++$-++(#"((%(&$+'*&)+$*-.--)&'%)&+,++%,--.,-,-(&)*(-)$,--,+*(*%,,)#'*--)(*---++'($+$$$,--,*+).+*-.-,,,&)#'*+*+%-,')),'-,+'++(+&*$+)-,++,,%,($(%""%*'',((,*#('*)(*('+%*$+.-.,*-+,%),,),,(%((,((-,(,+$,-+,-,))-,-),.--)),-*--,--,***+#)+*+$+*(&'-%&'(&'&&,++,',(*'&')),)%))$+)+&"+,,,-,$,-(,',),-,)#*(+)(*,,*-(&''))(-+,-(,'-,-'#,--,*)*')$((,,,-,--(*&&$)(-(''',$'((%+,)((((#*,-,)+)(''(,+##&),$*+()--,+(%)(('%'&')--*--)(+),)+$('+(),--(**-,,)++'*-*---(.,),'+*+,)%#+,,%'(*)(,-)$"$'*+,)&)*$+-)*)*$+,$))$('$(%%'(-*+)-*+$'++#)+()(+,'%&+&(')+((,*(&,)+$+-,),,,-'(,)&+,()(((#&(+('-(',.,-,-,+),---*)(&#$+,*#&*+,+-*,++%.,*&+(+),'('')*%(,,-()(+(,+),+)+(*#*(-.,'((,+&%$)',)#(&*%&*&))+-,,(%()%**)#,-,(.-*)&%$%&#*(&(&$+'(&).-)#"")&*%--(&*)--.-+*---,,*+**#(----*-*)','#'-.+(,((,()((,-,,'('',-(++&+,-,-)-))(,&,--)(('&#(*'+))/(),.)/,-*-+1221--,.0.*.*'..++'&/--001)'%11)/00()/++*/+(-0*+1/,+&/,121-)/1.,11,11-0'..+/&0-,'-0,,*&*./1---,1+-2-,,-,/1+-01,0-**+%-)*,,2-1.+0-/+*',1/&,100201-0'01,10/0'*%(1-),$)0/,1,.%,1+,./00+00.&.-$%(00(+,,+0%)+/$/'$(,$&&+///&0,0)-*,*.*/0(-).'-,,%-.,$+-+/2'"#.0&*)&/-%+0'-&/11)-%1'#+1/1*,%-,-1,.%/01,.01+0,/),-+,+-/22-.1121-1/++,--/'&-1-*/-0,00)-(.//$./,--*%,*/.+'/..)0-1.-0,-,,*200./,0.1-02-)00+1/%(*/%-.///'/--+.11. @rCer/2458/2627_54_CCS ATGGGGTGGCCGGGACACGTGGTGCGGAACCGGCGCCGCGCTTTCTGCTGAACCTTCAAGATCTGCGGTCTGGGCTTTGGTTGAAAGATGGCGGCCCTCACGACCCTGTTTAAGTACATTGATGAAAATCAGGATCGCTACATTAAGAAACTCGCAAAATGGGTAGCTATCCAGAGTGTGTCCGCGTGGCCCGAGAAGAGAGGTGAAATCAGGAGGATGATGGAGGTTGCTGCCGCAGATGTTAAGCAGTTGGGCGGCTCTGTGGAACTGGTGGATATCGGAAAACAAAAGCTCCCTGATGGCTCGGAGATCCCGCTCCCTCCTATTCTGCTCGGCAAACTGGGCTCCGACCACAGAAGAAGACGGTGTGCATTTACGGGCACCTGGACGTGCAGCCTGCAGCCCTGGAGGACGGCTGGGACAGCGAGCCCTTCACCCTGGTGGAGCGAGACGGCAAGCTGTACGGGAGAGGTTCAACTGATGATAAGGGCCCGGTGGCCGGCTGGATAAACGCCCTGGAAGCGTATCAGAAAACAGACCAGGAGATTCCTGTCAACGTCCGATTCTGCCTTGAAGGCATGGAGGAGTCAGGCTCCGAGGGCCTAGACGAGCTGATTTTCGCCCAGAAAGACACATTCTTTAAGGATGTGGACTATGTCTGCATTTCTGACAATTACTGGTTGGGAAAGAAGAAACCCTGCATCACCTATGGCCTCAGGGGCATTTGCTACTTTTTCATCGAGGTGGAGTGCAGCAACAAAGACCTCCATTCCGGGGTGTACGGGGGCTCGGTGCACGAGGCCATGACTGATCTCATTTTGCTGATGGGCTCTTTGGTGGACAAGAGGGGGAACATCCTGATCCCCGGCATTAACGAGGCCGTGGCCGCCGTCACGGAAGAGGAGCACAAGCTGTACGACGACATCGACTTTGACATAGAGGAGTTTGCCAAGGACGTGGGGGCGCAGATCCTCCTGCACAACAACAAGAAAGACATCCTCATGCACCGATGGCGGTTCCCGTCTCTCTCCCTCCATGGCATCGAAGGCGCCTTCTCTGGGTCGGGGGCCAAGACCGTGATTCCCAGGAAGGTGGTTGGCAAGTTCTCCATCAGGCTCGTGCCGAACATGACTCCTGAAGTCGTCAGCGAGCAGGTCACAAGCTACCTAACTAAGAAGTTTGCTGAACTGCACAGCCCCAACGAGTTCAAGGTGTACATGGGCCACGGTGGGAAGCCCTGGGTCACCGACTGCAGTCACCCTCATTACGTAGCTGGGAGAAGAGCCATGAAGACAGTTTTTTGGTGTTGAGGCAGACTTGACCAGGGAAGGCGGCAGTATTCCCCGTGACCTTGACCTTTCAGGAGGCCACGGGCAAGAACATCATGCTACTGCCTATGGGGTCGGCGGATGACGGAGCCCACTCCCAGAATGAAAAGCTCAACAGGCATAACTACATAGAGGGAACCAAGATGCTCGCCGCGTACCTCTATGAGGTCTCCCAGCTGAAGGACTAGGCCCGGCCTCCTGTGTGTCGCCTCCAACGAGAAGGAATCCTGCCCTCACCTCACCCTTTTCCGACTTGCCCAGGGAAGTGGAGGTTCCCTCTTTCCTTTCCCTCTTGTCAGGTCATCTACGACTTCAGAGAACAGACACAAGTGTATCCAGCTGTCCATGGGTAGAGCTACCCGATGGGCTTATGAGTGACCTAGAGTGACAGCTGAGTCACCCTGGGTAAGTTCTCGGAGTGGTCAGGATGGCTTGACCTGCAGAAAATACCCAAGGTCCAAAAGCACAAGGTCTGCAGAAAGTTCTGGTTGTTGACTGGGTACCACAGTTCACACCTATAATCCCAGCACTTTAGGAGGCCAAGGCAGGAGGATCACTTGAGGCCAGGAGTCTGAGACCAGCCTAGGCAACAAAACAAGACTCTGTCTCTACAAAAAGTTTAAGAAATGAACCAGACATGATGGTGTATGCCTGTAGTCCCAGCCACTCAGAAGGCCGAGGCAGGAGGATCGCTCGAGACCAAGAGTTTGAGCTTGCAGTGAGCTATGATTGCACCACTGCACTCAAGTCTGGGCAATGTAGCGAGACCCCGTCTACAAGAAGTTTTTTAAAAAAATGAGCCAGGTGTGGTGGTGCACGCCTGTAGTCCCAGCTACTCAGGACACTGATGTAGGAGGGTTGCTTGAGACTGAGAGTTGGAGGCTGCAATGAGCCGTGACTGCCCCACTGCACTCCAGCCTGGGCGACAGAACAAGACCCCATCTCAAAAAAAAAAAAAAAATTCTGGTTGTCATTGAATTGGGATAAACAGAGAGTTTGATGCTTTCTGCCTTCTGTCTCAGGTGATGCATTGCACATTTGGGATATATGGAAAGGAAATGAGGAGAGAAGTCAGGGCCTCCTCTGATCTCTCGCTATCTGCGGGTCCTGTCCTTTCTCAAGACCTTCACCATTACTGGCGTTTCCCTGTCTTCTCTTTAGTATGATCCCTCAAAACCTCACCTAACTGGAAGGATGATTTTGTCTCAGTTTGTAACTCCTAAATAAAAAGTAAACATGACACCT + BAEB=8;E?C4C?=?B=<3;09>A,C@D@B>CAEEBDEB39==@@DC?E7=D?F:A@ACAA@D:CCDDA.CCF9C=EAEDC8??CC;FGDED1B?;A?@CEFED?F>@<>:CCFE?EDGC?;A)B@>=>@@CF@AAFBG>E>>;C6F?EAC>EB0BA=:;?9?GFFFEC?BDE@?C@==AC@CB?BA/?DEEBDF>BCBDCFDBCB=@@;A9@DB:EAD/A=@D>DEFGGCDBEB<7EAEBABDCBEECACF;B?C3:FGCBB>EAB;9%=A8ECDE==2CBCAFC<9AED<9FEADDB4?5E@?BEC>?=EFG=F<<+DG=@@EAEB'ACB;@@??66BA?A>9:=C;AB7AABCA;;>7==79B?7?A9A?A?@6@>@>>BA>@A?AB6@>><@:%@A9?;BA9A)>:<.69;BAA?B-=BAAC99?:7>=A9>:B6@;@;AA=AB>9<9C@B@;C6B?:A<32B@9BC>?@<<=C>A;A?@B@C7?<38;B?@==7>@A?>@;@>:<&A=A@8>=B>BBC?<@.898>9;9@AB;=:>A>@B9B@-<;?6?AC@:92<@:?>A@>:BB7?=79A*@CA8A@9@=@@<<;B<@9>A;:=7=8@8=A0:;;=<;8?<<<:8%@;2@?@1>83?9AC8<8=?==>BB?:7%;7A>>@;38A>CCB=A9:?<;A>CAA@<>6@AB7B?CC?@<:A::0?'<@?;B=9?>81>9?CAB;@;CBBA@CB>96<;*7=B@>=ABB;<@:?68@<>=7>6CA>@@A>6>:=A>>>B?C@<=9<6>=-==7;@5=>A=::@75>B?>A@BB=@99>?9?=>:38=76:7876::2*11649=3929<3==89<<8766=78:=6<6+689::7?;3:'78>><7>8<>978585)9><:7;848;$5<=;86>91-46236815=4:;;;?=>?6<63<;87<6;?2;7=7:097=2=<=>916;;13;;?8*::=>?::=9><596;8<379;:88>=;=1<=?<4<=?<>4;:2>><:=;:89='=89=52668-=0;9/:>::86-9954643:6>>5,8466688<8;:?;<<2<8866=8:<7;4=>7<=,;9?877==;39=:27(78=079>=>:=:=:=97<:>6=:=8?>=<749==7==5>=21<9>:6:79;>86216:28=:>9:99)72083)8=)=78/::59;99;:35760>=:=/<>=:74=72:?<5?09=8<87,;69=5:>==-=8>?679*;::9<8;9;9<93=98;=:><=9;3888=2>>67641748>:937;4<96896<38:4:4399=6;9<594>:687137:3:768;2:>517)88<=1.=>68>;>>>8527;7965=17;;8358+5<0<97<7=:9>88=>5-5=69:;7===30417:<;65389=>>>36,9:=<=982;176:98895-57<8:460)+:6317$28:602:68263934-93*964=?>:<;729:39?<<::=8=6;/23<9=:8:618;;967>;837>;3986>>9;9829=?5:>=7>?:2659)>;=;399715=;>>::/0762+=>>34+13706<89=7:9.3<;3388589:43;=7><7;>19=-<4;:;>8624=7?9?8<3:8<9=:98;79==:983;9<57:/5::9;46:=<;3;49994479=987198>98436799;:1<8=6><7;<<53;46860.96;;::51)9;69;9?635788:899(>=?=<:97>:;2=?45;8716:::>98:68<-8::946=<9;5:=<==93;9<;75,782?7;9<9<;93;=:3:67=:;33801*)1=7;3=3328:42979=:>/;<586994:085::::60609996:5982665;7.5><:38=:<;<<<;:;88;;'=3>>9:?9<.4:=;3<2<8=?494:=7;;8*<<=5:3786:9;:9<996697/::8=55><<39/2=:2;/<:89<;?2:;9::=8;<=9:6-7185+6=8:=<93<=49>8<==5?;6.1+5/;=7:881:;81694-2/7=91=8:664.::%02-9(75:=;<8679391/98;87787-78/6:87<.34662//%/28::<==:7=;9;);<:<8:49:7;::/5-37<8989:>19<:;:/;:1-142#2985<697:=;<<,<<:;68498335:27 @rCer/2459/25_2249_CCS ATGGGATTGAACTCGCCTGCAGCTCCGGGGCTTCTGTGACTTTTGTCTTTATCGGAGCCAGGCTTACACGCCAGCAACCATGTCCAAGGACCTGCAGTTGGTATGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTAGAGATAATTGCCAATGATCAGGGAAACCGAACCACTCCAAGCTATGTTGCCTTTACGGACACTGAACGGTTGATCGGTGACGCTGCAAAGAATCAAGTTTGCAATGAACCCCACCAACACAGTTTTTTGATGCCAAACGTCTGATTGACGCAGATTTGATTGATGCTGTTGTCCAGTCTGATATGAAGCATTGGCCCTTCATGGTGGTGAATGATGCCTGGCAGGCCCAAGGTCCAAGTAAGAATATAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTATCCTCTATGGTTCTGACAAAGATTGAAGGAATTGCAGAAGCCTATCTTGGGAAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTATTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTTACGGCTTAGACAAAAGGTGTGGAGCAGAAAGAAACGTGCTTATCTTTGACCTGGGAGGTGGCACTTTCGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTTAACCATTTTATTGCAGAGTTCAAGCGCAAGCATAAGAAGGACATCAGCGAGAACAAGAGAGCCTGTAAGACGCCTTCGTACTGCTTGTGAAGTGCTAAGCGTACGCTCTTCCAGCACCCAGGCCAGTATTGAGATCGCTTCTCTCTATGAAGGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCGTGGCCCTGGACCCAGTAGAGAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTTCTACTCGTACCCCAAGATTCAGAAGCTTCTCCAAGATTTCTTCACGGAAAAGAACTGAATAAGAGCATCAAACCCTGATGAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAATCTGAAAATGTCAAGATTTGTTGCTCTTGGATGTCACTCCTCTTCCCTTGGTATTGAACTGCTGGTGGAGTAATGACCGTCCTTATTAAGCGTAATACCACCATTCCTACAAGCAGACACAGACCTTCACTACCTATTCTGAAACCAGCTGGTGTGCTTATTCAGGTCTATGAAGGAGAGCGTGCCATGACCAAGGATACAACCTGTTGGCAAGTTTGAACTCACGGGCATACCTCCTGCACCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCCAAGTGGTATCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAGAGAATAAGACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAGAACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGACTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCTGCCAGGAGGAATGCCTGGGGGATTCCCTTGGTGGAGCTCCTCCCTCTGTGGTGCTTCCTCAGGGCCACTATTGAAGAGGTTGATTAAGCACCCAAGTATAGGTGTAGCTTGTTCCACACATTTAAAACATTTGAAGGACCTAATTTGTAGCAATTCTGTGGCAGTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAATGCAATGCTTAAATAAACTATTTAAATTGGCAC + ./..142541,3202--,13/25523#..0*'*-/4140+',10,+)&43231,2).250,2.'-/32/334)41.3*0*)-3023/$4/2612551-0-50-$1(%**0,/--(30+02-*.*)*.,0(*,4(+)241'-124,0(2(144441+-1'-+,+*.-/(.1552//&-.)4/,//02-611--3,1+,24-3/31/6&21.3)2)02230)1305/02-2002.1*021+33(235.2(2-4*&/0321440-5-3./)+)$,&-)1/%**./.+&'')+$'+/.)./10+/$),****)'+.(%$%#%+*&*-,*-.+1//'*'*)'+*-'.,/,&('0',.02/,-$-++.--1.1.*''#*,)1/%,-+10''',*/+/1$'$#(%*"$'%'),+((-,&*.)00+')++++%-/2&,++/(&-*.+-200&'.12),,,,)'*00,##(*%*&)')$$&(&-*+,-+)//,*&&0+&&*(**/,10,/%,-&$'+/(1-/.+&&%%$+),,-0-)//1020+(**%,*-,,+$$,++%/+).&+),&*.),'-*.0,,*0/)&$(---/+0),0//+-',(1(+),1/1&./$'(**(+--*.'*.1,,/21*%.-*+(**(+(*$&$()/(%,$$#%%*)&)#'(*%)(*&&(*$),*)%),+/'.-',.*"&(+0,,0),/,)%%,,%,0%-*,0*.+-/-(-)+,2,/%-&))+*)-*/.21&&,/(++1000&+0-11+*&+/..+0-.11100'()')$*///.+$(*+,*%)+,#**/(+.(011)'.*-+%*--+1,-,11/%,+'&&')*)0,/)-.1+(,/*+.(//).,',-(##&&**-,'&+&)+,&(,)#&(#$%',+%&#'%'%(',+,'(,,(&%#%&(*--)(--+&+&*)($"$&+),,-+(#"&'()**)%*(&,#$&&$#+-+#"$&&"&'(-,,-%&-++-,)%'&()-,(+(,)--($&$'&(*'+*-,$&((,,)++)(($#,++-)('+%%()*(+$+&%)*(,&,-+(*+'($&*)##$%*'+'*)*)+,&**,))*'('&(*-+-)',)+++'&(#%&'%)&$(+,''+-+&&*&$,,-*)+((*,--*+'),--..,+**#*,-(,-++'+',,#&'(,)')&(&*$)'#&'+*%&"##$$%#&((',*&(+*,*,&')$$$(*&*))&&+$++,),*()).)+&*(%$(*&$()(('#)),,+&,+++-*'&''*),,)++++(+*,'&$,"$%%&&)+&+,*#)(+)')+*+,-+,*','++,-()*(-.--.,.)*,)$(,+',&(*),*)*(*$(-,)))+--*+&*)-+.-+++$',*)(,+'+$"&+,&$$+,.(-,('$)'((,()-+),-(,*-*-*+*%(%())-(++)+,(,)-(('').+.+(&-,-)*,((,)''()--((%()&'%%*,%#&',,*#''(,('+(#,*,()%%#"%%&))'&%'&(+)(&%,')())+$&"#($))*($)'()+#*+)+,%&#(+-)+)-,-)+&,('),(+,$+(%&(&)*')(#$*&)(+(,+-%$&+),&)++.-,)--((+&''-%(#&)(,--,-'+'))+.,&(-,-)-)(%(*)+,,(&((,))+''),))&&,)%%(+()&(-+$)(&#,(+'),&"$$+(,*&*+-)%.-+)+*.---+(*&,-,*)+'+(,-,())*,*+-,&'(*)(('*,-+&)))&,.+(+%*+-'+,),''(%*)+&,+*,,)-,,)++,--++#))(*)%''%(*&))(+&.--(-''$---()*'&#(&#'&%'&&*)*+'+(*-+*+..-),(&-*,-)(,)-+,)#(&,(++,,)%++'*)-&++*+%*()-,'-),--'*+(*-&)()(--+)++,.+#,)))(($)-%)+,(,*()++))')$$$""$$%$&(&,,$)($)*&"##&(*&''(-))',,',*$)'++,'*,$),,(.+-)()(',&"###%'),,(&*)-'+**,&#,'#')-,(+--%&'&),*,,(,,+&,&,--.+#,$'+,)()(&+'('())$%)-+#)('----,'+%*+&#%(('+,-,(-,*-,),$*&)-,,+*-)-,,)+,,,(---+-')*)---,-''.-*&,()%''))--(,*&%$'$%$()'',)(',--,,-++&#&)&%#*)*-,%)''"(,)--+#)*,1.%,*(*-,2%,+/) @rCer/2465/25_1935_CCS ATGGGCTAGATAAAAAAAAAAAAGAAGTAAATGTTTCACTGCTCTATTTATATATAATGTCTGAATTAATTCTGTGCAGGAAAGGCCAGGAAATTGCATGTGAAGTTCGGTGCAGTCACCACCTCTGTGTGACCTGAGCTGCAGTCTCTTCGCTGAGATGCAGATTTTAAATGAGACTGGGGCTGAGGGCAGGCCTCAGGCCTCCCAGCGCCCCAACCCCTCCTGGTCTGATTAAATGCAGTTCTTAGTGCAGAGACGTTTTAAGGTGCAATATATCTCTTCCTTTCACGTGGTTTTAGAGCCAAGCTCAAGGTAGTAGGACGTAGGGTCTTATTTTGTTTTCAAACCCCCATCTTCAGAGCGTAGATACATGCAGAGGCTTCTGCCAGGATACCACGGGGCCTTGGTGGGAACAGGTGGAGACCAGCGCTTGCCTTTTCTGCTGCTGAGTGGGGGTCAGAACCCACTCACTTTTGCCTGCTCAAGTTGCCCTCTTCCCGATGCTGGCAGCTCTGCCTTTGCCATCGGGGGTGCGGCCCATTGCTCAGCAACCAGTGGCCTTGCGGTGTATTTGTCCACTGTCCGCTAGAGTGGGATGAAGTCCAGAGTGTGGGTGTGCATCTGAAATGCTCATCCACCCACTGGGGACTTCAATGCCAGCTGCATTCGGTTTGGTTTTCTTCACTGTTGGCTTCTCCCCCCAGTTTTTTTTTTTTTTAAACATTTGTATTGTTTTCAAACTTGGAATTCATAGACACTCTGGCTCTAGGTTCCTTAAGGGGGAAACAAAGGATGACTTTATTTCACATTCAAGAAATCAGTTCAGTTCCAAAGCTGTGGTCCTTCCAGCCACTTCTAGGGACACTGGGGTACCTTGTTAAACATTCACATCAGTGCTCTCCAGCCGAGCTGTCGCCCTCCTATCTAATGGATCTGCCTTCCGGATGGTCAGTGACGCCTTCTGGAAGCTGAGCGCACACAGGTGCACGGCCGTGCTGTGGCCTGGCCTGCTGCGGCAGCATGGCAGCTCTGGTGGAGCCTGCTCCCTGCCATTTGGTTCCCCTCTGCCAAGACTGCAGGCTGCCCCTCAAATCTTCATTTGTCCCTTTTCACTTCCTGCAGAGCAAGCCTAGGTTAGAGGGTCTGCTGGAAATGGCCTTTGAAGACCAAGGATACCAGAGTGTGTGTGCTCTGTCATATTCTGTGATGAATGGGAAACAGGCTTCCAGAAAGCCAGCTCTCTTCTGAAATGTGACGGACCTAAGCAGGAAGTCATCCAGGACAGGAGTGGCTTGGTGTTGGAGATGGACGCTGTTGCCCTGCCATGCTCCACCAGGGCCACCAGTGTATATCTGGCTGGTGGTCTTCGGGCACGTGAGACCTGCTCTTCACTGTCTCTACCCCAGTTGGTGGCCTCCAGGATGGTAGTGGCACCCCAGAGCCCCCATCTTCAGCATGTTCCGGAGCCTCGGAGTGGAAATTCCTGCTAAGGCTCTGTGTAGACGCCTTTCTCCCATGATCTAAAGGGGACACTGTACTCTTAAGCTTTTGACCTCTGCCTTGTGTAGTAAAAAAAGGATTGGGGGTTTTGTTGGTTCCTTGAGAGGGCTGTGTTTTTGTTTTGTTTCCTTTTGTTATGTTTTGGCCTTTCCTCTTTGTCTTTCCATGTAGACCAGATATTTGAAAGGGCAGACGATGGCTAGAGGTGTAAGTGCAGCTTGTTTAGACGTTATTTCGGGAAACTTACCTTGGATGGGAAATGGAATCGTGGATTCACCAGGCCGGTGCTGGCACACTCAAACCCTCGCCCTTTCCCTCCGGTTCAGTACCTATTGTTTCTCCTTTCAAATATGTGATTGTACTAGCTCTTTCCATATGAAAGATTCTCCTTATTTAAATAAAAAAAAGTT 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@rCer/2466/0_2383_CCS GAATCTTCCATTCTGTTTCAAACATCAGCTCAGTGGATTTGATCAAAGCTCGTCTTTATTCGTGCCTTGTCACATGAGAGAGGTACTTGGAGATGCGTGCCAGATGAAATATAATTGAGCAGTCTGAAGAACAGTATTGATGTGCAGAAGGCTTTGTCAGGGGTTCTGACAAGATAGAGTGCAGAATTGAAGGACAAGAATGAGGGAACATATCTACAAGAAAGATGGCAAAGGAAAACCAGTAGATTCCCGACATCGCGAAGTGAATCTGAAATGTGCAAAAGTTGCTAAAATGACTGTATCTGGAAAGAAAGCAAACTATGGGATTTGAAGTGCCTGGAGTATCTTCTGAAGAAATGGTCATAGTTTCACACACCTCAAAGAACGGCCCATGAAGATGCCATTGCTTCTTTGATGTTCTTGAACTGCTTCTAAATCTGCTAATCCACCCCTGACGGTTCAAGCATCAGAAGAGCAGAGTTCAACCCCGCACCGGTGAAAAAGTCTGGCAAGCTGAGGCAGCATTAGATGTGAAGGCGAACTGGAGAAGCGGCAAGGAGGGAAGAGCTCCTCAACTTGGTGGTCATTGGTCATGTTGATGCTGGGAAAAGTACTCTGATGGGCCATATGCTTTATCTTCTGGGTAATATAAACAAAGAACTATGCTAAGTATGAACAGGAGTCTAAAAGGCTGGCAAGCTTCGTTGCATATGCATGGGTCTTGGATGAAATGGCGAGAAAGGGAAAGGGGAGTAACATGGTGTTGGTATGACAAAGTTTGACCAAACCAAACATGATGCACCATAAGGATTCTTCCATAGTTAGGAGCAGCCCAGGCGGATGTAGCTGTTTTGTTGTAGAGCGGAGGAGGTTTGAGTGGATTTGAGACTGGAGGACAACACGAGGCATGGGACTCTTGGTCGTTCTCTGGAGTGACGCAGCTTGCTGTTGCAGTTAATAAAATGGATCAGGTTAATTGGCACAAGAAAGATTTCAAGAGATTACTGGAAAACTTGGCACTTTCTTAAGCAAGCAGGTTTTAAGGAGAGTGATGTAGCTTTTATTCTAAGTGGTCTCAGTGGTGAAATCTAATCACAGATCTCAGTCAAGTGAATCACAAATGGTATAAAGGACTATGTTTATTAGACAAATTGATTCCTTTAAGCCTCCCAGCGATCTATTGACAAGCTTTTAGTTATGTGTGTCTGATGTTTTCAAGATCAAGGATCTGGATTTTGCATAATGGTAAATTGAAGCTGGTTATATCCAATGGTGACCGACTACAGGCATGCTCCTAATGAACTTGTACCGTAAAGGAATCACTCTGCATGATGAACTGTTGATTGGGCAGCAGCAGGCGATATGTTAGTCTTTACTTTGGTTGGGATGGATATCATCAAAATCAATGTTGGCTGCATATTTGTGGCCCAAAGAACCTATTAAAGCTTGCACTCGCTTCAGAGCCGAATCTCATCTTTAATATTGAATTCCTATCACTAAAGGATTTCCTGTGCTGTTACACTACCAACTGTCAGTGAACCGCCGTTATTAACGATTGATTAGTGTCTTAAACAAAAGCACGGGTGAGTCACAAAGAAAAGCCTAAGTTTTTGACTAAAGGCCAGAATGCATTGGTAGAGCTGCAGACACAAGACAATAGCTCTTGAGCTGTATAAAGACTTTAAGAGCTGGGGAGGTTCATGCTACGTTACGGTGGTTCTACAATAGCTGCTGGTGTTGTCACTGAGATAAAGAATGATGGGTCAGAATTTCTGCCGTGTTTCCGGATACAGTGAAATAGCTAACCTCTGTTTCAAAGAATCAGTCATTAAGTCAAAGGAACAATGTGCAATTGATATTTTTTTTAGATGAGAGGAAAAATTAAAGCTAAAATTAGCTGCAAGAAGTATTATAATCACCTCTGCAAAAATTATAAGTTGCCAACTGGCAAAGAAAGGCTAATGTTAAAACAACTTTCCCTTTGAAATGTTAGTAAATGGATTTACTTCGCTGAGATTTATGGCAAGTGTCAAAATAGTATCGAAGATACTGAATCATCATGAAATGAACTCTACTTCTGGCCAAAGCACAATGTATTGCAGTTTTCTCTTTTGATTCAATTATACTGCACATGTTTTAAGGAAAAGTAACTTAACTGGGTTTTTCAGGCAGTTGATATTTGACCTAAGCTTTTTTTTTTTTCGGTTACGCTAAGAAAAGATTGGGAAAGGTTATAATAAAGGTATTTTGTGGTGACCATAAGAATGTCCCTCCCCAAACAAGTAAACTTGTGAAGTTTAATTTGGAATTAGTGGAAGCTGTTCCTTTGAAAGCCAAGATATTATTTAAGTTGTAAAGCCAGCTAATAAAATGCCTTAGTTTG 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@rCer/2467/25_1947_CCS ATGGGAAGCAGTAGTATCAACGCAGAGTACATGGGGGAGGTAGCAGCAGACGCCTGAGAGCGAGACCGAGGCCCCTCAGGGTTTGGAGACCCTGACACACCCACCTTCTCACCTGGGCTCTGCATATCCCCCAGCCTTGAGGGAAGATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCAGAGGAGCCCGCCAACGAGCTGCCCATGAATGAGATTGAGGCGTGGAAGGCTGCGGAAAAGAAAGCCCGCTGGGTCCTGCTGGTCCTCATTCTGGCGGTTGTGGGCTTCGGAGCCCTGATGACTCAGCTGTTTCTATGGGAATACGGCGACTTGCATCTCTTTGGACCCAACCAGCGCCCAGCCCCCTGCTATGACCCTTGCGAAGCAGTGCTGGTGGAAAGCATTCCTGAGGGCCTGGACTTCCCCAATGCCTCCACGGGGAACCCTTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCCGGTGCGCACAGCAGCCTGGACATCGCCTCCTTCTACTGGACCCTCACCAACAATGACACCCACACGCAGGAGCCCTCTGCCCAGCAGGGTGAGGAGGTCCTCCGGCAGCTGCAGACCCTGGCACCCAAGGGCGTGAATGTCCGCATCGCTGTGAGCAAGCCCAACGGGCCCCAGCCACAGACGGACCTGCAGGCCCTGCTGCAGAGTGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTGCATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTGGCAGTGCCAACATGGACTGGCGTTCACTGACCCAGGTCAAGGAGCTGGGCGTGGTCATGTACAACTGCAGCTGCCTGGCTCGAGACCTGACCAAGATCTTTGAGGCCTACTGGTTCCTGGGCCAGGCAGGCAGCTCCATCCCATCAACTTGGCCCCGGTTCTATGACACCCGCTATAACCAAGAGACACCAATGGAGATCTGCCTCAATGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCGCCCCCACCCCTGTGTCCAAGTGGCCGCACTCCAGACCTGAAGGCTCTACTCAACGTGGTGGACAACGCGCGGAGTTTCATCTACGTCGCAGTCATGAACTACCTGCCCACTCTGGAGTTCTCCCACCCTCACAGGTTCTGGCCTGCCATTGACGATGGGCTGCGACGGGCCGCCTATGAGCGTGGCGTCAAGGTGCGCCTGCTCGTCAGCTGCTGGGGACACTCGGAGCCATCCATGCGGGCCTTCCTGCTCTCCCTGGCTGCCCTGCGTGACAACCATACCCACTCCGACATCCAGGTGAAACTCTTTGTGGTCCCCGCGGATGAGGCCCAGGCTCGAATCCCGTATGCCCGTGTCAACCACAACAAGTACATGGTGACTGAACGCGCCACCTACATCGGAACCTCCAACTGGTCGGGCAACTACTTCACGGAGACGGCGGGCACCTCGCTGCTGGTGATGCAGAACGGGAGGGGCAGTCTACGGAGCCAGCTGGAGGCCATTTTCCTGAGGGACTGGGACTCCCCTTACAGCCATGACCTTGATGCCTCAGCCGACAGCGTGGGCAATGCCTGCCGCCTGCTCTGAGGCCCGGTCCAGCGGACAGGCCGAGGCCTGCTAGGCCCCCACAGACCCAGATGCTCTGGGTCACGGTCCCTGTCCCCGTGCCCCCGCTTCTGTCTGCCCCATTGTGGCTCCTCAGGCTCTCTCCCCTGCTCTCCCACCTCTACCTCTGCCCCCACCGGTCTGACGCTGTGGCCCCAGGACCCAGCAGAGCTGGGGGAGGGATCAGCCCCCAAAGAAGTGGGGGTGCATGCTGGGCCCGGCCCCCTGGCCCACCCCCACTTTCCAGGGCAAAAAGGGCCCAGGGTGATAAGTAAATAACTTGTCT 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rCer/2470/0_1293_CCS GCAGCTACACGGTGACGCCCTAGCAGGCCCCGCGTACGCATGTGATAGTCGGGGAGATCGCTCACAGCACCGGCGCCCCTCTGCCAATTGGGCATGCTTGCGGAGCCGCCACAGGGGCGCGCGCTTAGCTCGCTCATGGGTCGCCTGCTGGTTTCTGAGCCCGGGAATGCAGCTGGCCCTGCGCAGTTGGACTCTAGACTTTTTCCTCCTGGACCCCCGCTCATTAACCAACCAACCCTGTCCACTTTGGCCCTCCCTCCCATTAGCCTCTCGGGTTTGGACCATTCCCCCTCCCTACCCCATCCCCACAACATGGGAAGAAGCTGCATCCAGGTACAAAATGTCGCTGAGTCTTCACATCTACTGCCAGACACCCCAAATCTGTTAGGCATTATGGATACATTTCCTCTAAACACACCAGGCACAGCAATACGACTTCATTTGCTTCGAGTTCCGTAGACACGACATGAATCGGGCTCTCTGCTCTTCGTCAGGGAGCTGGAGGCTGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTATCAGTCCTTTGACAGGGACAGGTGGGCAGAGAGCAAGGCAGGTAGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGGAATTAAATGGGAGTTCATCTGGCCTGGGTGGAGGCCAGGATCAGACCATGTGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGAGATGTGAACGTCCCTGAGGGAAGTTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATACGTCCATACCAAAACACCCCTGCCCACAACCAGCTTCCTGGCTGGTACCCATGATAATAATTGAGCTGAACCTTGGGCCCTCGTTGGGGAACAGGTGAGTCTATTTGAGACTTCTAGCCCCAGAAAACTGCCTCAGTCCGGAAATGGCTCTCATACAGGAGCTCGGCCCCCTTTTTTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGCCTGATCCACCTTTACACAGCCCAGGAAGCCCCATCTGTGCTTGCCTGAGGTGGTCGCAGTCACTTCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCCTTTCTATCCCAATCACCAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCTGTAAATGGGGGCTCCATTAGTTTCTGCTGCAGAGACTAATAAGATTTTGTTGGCTTTAG 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rCer/2471/1737_60_CCS ATGGGGAAAGTGCTGCAGACTCTTCCCTGAAGCTGCCGGCTGAGGCCGGAGCTGCCGCCTCCATGAGAGGCTTCCTCCTACACCCCAGGGCCAGAGGACCCTTTGCCACCAGAGTGAGATCCTAGAGACCATCATCCTGGTAATCCAGTGCAGACAGCATCAGCTCTGAGTTCACCGTTCTTAGCAGCTCATCAGCTCATAAACTACTAATCTTGAGTGGGCAAAGTTTGGAGCCCGGGGGAACCTCGTCCTACAGAGTGGCACCTACTCGTATGAAAACTTGCCCAGGTCCTTCACAACCCCGAGATCTCCCATTGCTCAGCAATAGAGACCCTGGGATCCAGGCCTTCCTCACCGTGTCGTGCTTAGGGAAGGTGATTGGAGCCACCTGGGATTATCCAGTTCCAGAGACCCTGCACCTCCGGCTAAACCCTGAGCCCACGCTGCCCACCATGGATGGCGTGGCTGAGTTCTCCGAGTATGTCTCTGAGACTGTGGACGTGCCATCCCCATTTGACCTGCTAGAGCCCCACCTCAGGGGCTTTCTCAAGCTCTCCAAGCCTTGTTGCTACATCTTCCCAGGTGGTCGTGGGGACTCTGCCCTCTTTGCTGTCAATGGTTTCAACATCCTGGTGGATGGTGGCTCTGATCGCAAGTCCTGCTTTTGGAAGCTGGTGCGGCATCTGGACGCATTGACTCGGTGCTACTCACACACATTGGGCAGACAACCTGCCAGGCATCAATGGACTACTGCAGCGCAAAGTGGCAGAGCTAGAGGAGGAGCAGTCCCAGGGCTCTAGCAGCTACAGCGACTGGGTGAAGAACCTTATCTCCCTGAGCTTGGAGTTGTCTTTTTCAACGTGCCTGAAAAGCTGCGGCTTCCTGATGCCTCCCGGAAAGCCAAGCGCAGCATGAGGAGGCCTGCCTCACTCTGCAGCACTTAAAACCGCCTGGGCATCCAGGCTGAGCCTCTGTATCGTGTGGTCAGCAACACCATTGAGCCACTGACCCTCTTCCACAAAATGGGTGTGGGCCGGCTGGATATGTATGTCCTCAACCCTGTCAAGGAACAGCAAGGAGATGCAGTTCCTCATGCAAAGTGGGCAGGAAATAGTAAAGCCAAGACAGGCATCGTGCTGGCCAATGGGAAGGAGGCTGAGATCTCCGTGCCCTACCTTACCTCTATCACTGCTCTGGTGGTCTGGCTACCAGCCAACCCCACTGAGAAGATTGTGCGTGTGCTTTTTCCAGGAAATGCTCCCAAAACAAGATCTTGGAGGGCCTGGAAAAGCTTCGGATCTGGACTTCCTGCGTTACCCTGTGGCCACACAGAAGGACCTGGCTTCTGGGGCTGTGCCTACCAACCTCAAGCCCAGCAAAATCAAACAGCGGGCTGATAGCAGGAGAGCCTCAAAGCCACTACCAAGACAGCCGTGAGCAAGTTGGCCAAACGGGAGGAGGTGGTGGAAGAGGGAGCCAAGGAGGCCCGCTCAGAGCTGGCCAAGGAGTTAGCCAAAACAGAGAAGAAGGCAAAAGAGTCATCTGAGAAGCCCCAGAGAAGCCTGCCAAGCCTGAGAGGGTGAGGACAGAGTCAAGTGAGGCACTGAAGGCAGAGAAGCGAAAGCTGATCAAAGACAAGGTAGGGAAAAAGCACCTTAAAGAAAAGATATCAAAGCT + 4.267$1=*:-222:71;:287:4<@46;?-@;#:=1A5>57=@4A*A48AB9;C;;?85@556@:7;7+4>(0(1;3(7.05@>*?B?)>,=:?@051?,49?6;=9023<01))42-)7?:;;'5@/9;+;7:4/;4,*.66712:-8?7)<,4,6.&)$-1%<,==44,63>==613-7?2>'3390@C@6=@53:.=A;.:2:&@>A.>7>=>=0BDD9/,,B>:6C7;'A3BD;>ADG->?C7C79;=CD;/.=EB2:A%CBB&BC-2>5E3?BBG;DI=+:3:A?>?:62#=9;B=ACB:1986FE7?HE0GCEC@I)E>E698@@HH@D4B>&@GF2BC6=2C;;6F=I*#&,:?EE0;9;8G78E8H;C0D@-3?&8:?7=D/7BFF89CC08CFA@F@:AA@B?<@:?>:E.:47,'<$F*DFB3AC@+DC@>:4:.>@>'4A170>BCD,4;B+;EAH8G<9==F/9.2>6C)5B5A=93AA<5E:DG82G>=G:BECDJIH.>:BCD<@F9CDE>*2.89?9@0?C>HH@<>7.97D:IFA:>,3:?05C58*?:G>3CGDC(//?20@6=IC*FAICD@9>/<:8?2;:>?AD;4$:*.A:5D5EE?8:;788;:675;885@C8CF13@85-7+?8:>B21#8-989$,7315?8?6=943@(A8::)9:6>88>>?7>79'495$6508/.5C<=;3&<;=<<.;62AB15=<&=*<=*ACB./(4@775091=4:126:;90?D(C9?7/?8><2>?86;8=001<:@6CCB;A24?B%?DA983A/(6;/2,%;<>>:A>5CA,/A9'+D38-74@6B8;AB'E5BGACA?74:E9>=#5;;=@8-<;'B3?FD;B)28>$3:99+6)?/=C=CB:<*:E?EFA=B>@0;>;-:;@AE:55FGD5DC@FFB49?=2A=;@&?615--.<<9>6AE?>26=1>C-:6C>>A%,;AF2AA;9.A5@D3A9*B8BAE=;BE4BB@)>/2CFC>;<6A5:ACE/<58A0D?:ABAEC::D?=%2:<+F91<)9BE2E5@F5@@B::FE>;?;:(50.99;?A;*=A@9C<:98;DE8::?=<>:@(183@E.D=?F@?>A@*:=?D7CB96FA8DG?C,0:@G:G>?D+7DE>39:D @rCer/2473/0_1421_CCS AACCCTTATCTCCCTGACCCTCCCAATTTGCCACCTCACAACCCCTACAAAAAACGCCCATACCAGATACTAAAACAACCGTAATATATGCTTCATCATCAGCCTCCCTCCAACATTATCATCTTCTCAAACCAAGAAACAACATTGGAGCTGACATTGAAATAACCAACCTAGACCTAACGCTGAGCTTCAAATTAGATTACTTCTCATAATATTCATTCCAATCGCACTATCATCACCTTGGCATTATAGAATCTCACTATGATACATAAACTCAGACCCAATATCACCAATTCTTCAAATACCTCCTATTCCTCACTGCCATACTAATTCTAGCACTGCCAACAACCTCTTCCAATTCTTATCGGCTGAGAGGGCGTAGGAATCATATCTTTTCTCCTATTAGCTGATGATACGCTCGAACAGACGCTAATACAGCAGCCATCCAAGCAATCTTATATAATCGCATGGCGACATTGGTCTTATCCTAGCCATAGCATGATTTCTCCTACATTGTAACTCATGAGACTCCACAAATACTAGCCCTAAATCTCAACTCAAACCCCCTCCCACTAATAGGCCTCCTCCTAGCAGCAGCAGGAAAATCAGCTCAATTCGCCTTCATCCCTGACTACCTTCTGCCATAGAAGGCCCAACTCCAGTCTCAGCCCTACTTCACTCCAGTACCATAGTCGTTGCCGGAGTGTTCTTACTCATCCGCTTCCACCCTCTAATAAAACCAACACAATGATTCAAAATCTTACATTATGCCTGGGAGCTATTACTACCCATTTACAGCCATCTGTGCCTCACACAAACGACATTAAAAAATTGTAGCCTTCTCTACCTCAAGCCACTAGGCCTAATAATAATCACCATTGGCATCAATCAACCATACTTAGCATTCCTACACATCTGCACCATGCTCTTAAAGCCATACTTTTATATGCTCCGGATCCATTATCCTAACCTAAACAACGAACAAGACATTCGAAAAATAGAGGCCTATTCAAACAATACCTCTCACCTCAACTTCCATAATCATTGGCACCTAGCACTTACAGGAATGCCCTTCCTCACAGGCTTCTACTCCAAAGACCTTATTATCGAAGCCACAAACACGTCGTACACCAACGCCTGAGCCCTATTCATACTCTCATCACTACTCTCTAACAGCGCCTACAGCACTCGAACCATCCCCTCACCCTAACAGGACAACCCCGTTTTCCAGCCCTAACAACATCAACGAAAACAACCCCACCCACTAAACCATTAAACGCCTCACAATGGGCAGTATAATCACAGGATTTCTAATCACCAACAACATCCCCCCACCTCACTCCCCCAACCAGCAATACCCTCTACCTAAAACTCTCAGCCTATGCGCAACGCCCTAGGCTTCTAGCAGCCTAGACTCACCT + S&-1.&(,'./.22'/(%**'$-/&(&+)+.2*&,$)#$(*$110+0/%'"$,-*+&00*./'.-**'$'$%../.+0-.-.-0))+,+*%#$)-,..11-/02&(+)&**.1-"#)+(,*&&)-+(.*00/2*0)(0/&'+$+$+&-+,(++&'%)-,%)$)(,')$)'#$'+(')$))111+/*)$&+*&,-)0-)$#,./&&+)&$.+//.&.,,%.+-,0-,,-+..(')****+0%+)&$&%+2/*,*'%.0//00/4,(&53(('/6712.3-97629.57*'1:23&+*%/3-/8383;2*(%0$858474-298;10821-6/62+11&0&/058342.79:21$&3709&((,-.0507-2*3.72598:6737-7&803169*634**57-(+0476606673355685/35744585892-953:2664)%+*&*84788+657,55265363377.$/87605854'427(052-712746345:63)+3+55024712(/+44017656,...-.),01&'#+.30(/+31843,2576/7(7535'/3+66284'78586/763-3)1(&//)75*69.352886+6)57445&466728759%*1848045:9336442/859/03-8/62319065:;2888+8564152,6)3538849:66489326%181.07402+3,,7/94((*)4$%10/7/4-1:64+71:33;;79/442)%0417)2-55-//09)31&2.-,'+514.2974)+:7+:843461(-/4/-,1.')-'''49476/44789(6(2427*'4/(,)-2('#78888"+33/5*3(854524/692-5+.-&5/11:1507;5/5,*86::8;747*4612/555/,7767915-2.52-)0(0.-205/.4+2,+%,.10/#%%2.22-.0410,#/01,1.+-0*&,,400+322510//%'..63.501+45616/+4/040*351)033312*(.6,300+-)$3///142,5.//,0*5,0'0'-3+2+()3'11&-'42$-23)42410455.46,1+1.64,502-1110.2/,-111.+&,3664)/2'/4.3/--3+1/0640/661'1215-'.0,%))'0004-3-/.64.2-.2-%%''**.)'2/5-3-155,&133%59:5/744).7.%693*51.,+*-,1-*.)2340.,//60,(/(/03/*1334600/50).4/$2(,/4'00)(4330-5(32*.**)%*++6.$1&%.&43/+/613'/06-+61-*2*.-'04554,-23*/*'$%/-21.0'/306+-($0./-/((2+0201$2/.-)2.2*,1/42#&53-.%0&-&-445*24/014*5/.01.)1%-&#,54/0,64'*'-++1.'%0/0.-$,(*%,) @rCer/2474/1576_60_CCS ATGGGATTTGGGGAATGGGATGCGCGAACCGGGTCCCTTCCCTTTCTGTCCATCCCAGGTCTCCTACCCGACTTGCTCGGACCCGCCGCTAGGTCCCAGGCAGAAATCAGCTAGTGATTCCCACTTTCCGCCCTGTATCTTGTTCTTCCCCTGCTTGTTTTTGTGTTCTGGCCCATGCCTGATTTCTCGTCCCACGCCCAGGGAGCGAGTCAAGGCCATGTTCTACCACGCCTACGACAGCTACCTGGAGAATGCCTTTCCCTTCGATGAGCTACGACTCTCACCTGTGACGGGCACGACACCTGGGCAGTTTTTCTCTGACTCTAATTGACGCACTGGACACCTTGCTGATTTTGGGGAATGTCTCAGAATTCCAAAGAGTGGTTGAAGTGCTCCAGGACAACGTGGACTTTGATATTGATGTGAACGCCTCTGTGTTTGAAACCAACATTCGAGTGGTAGGAGGACTCCTGTCTGCTCATCTGCTCTCCAAGAAGGCTGGGGTGGAAGTAGAGGCTGGATGGCCTGTTCCGGGCCTCTCCTGAGAATGGCTGAGGAGGCGGCCCGAAAACTCCTCCCAGAGTATAACAAAGCCATCCGGAACTATACCCGCTTCGATGACTGGTACCTTTGGGTGCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTATTACACCGTATGGAAGCAGTTTGGGGGCTCCCGGAATTCTACAACATTCCTCAGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGATCCACCTTCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCATTCTTCCTGGCCGAGACTGTGAAATACCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAATAATGGCTCCACCTTTGACACAGTGATCACCCCTATGGGGAGTGCATCCTGGGGCTGGGGATACATCTTCAACACAGAAGCTCACCCCATCGACCTGCCGCCCTGCACTGCTGCCAGAGCTGAAGGAAGAGCAGTGGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGCAACAGGTCGAAATTTCAGAAAAGACTATGAGTTCGGGCCGTGGAACCCCAACAAGGCCAGGAACACTCCTCTCACCTGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAACAGAAGGTCCCACTTCTCAGCTGCCCAGTCAGCCTTCACCTCCAAGTTGGCATTACTGGACAGGTTTTCCTTGACTCCTCATAACCACTGGATAATTTTTTTATTTTATTTTTTGAGACTAAACTATAATAAAATGCTTTGGGT + KKKK7KKKBKKK*KKKKK4KKKKKKKKEKKKK@KKK9KJKK:KK+KKKKKKKKKK.KK5JKKKKKKKK:KKIKHKKKKKKKKK@KKIKKKKKCKKK(KKJKKKKKJKKKKKKKJKKKKKKKAKKKKJKJKKK7KKKKKKKKKKKJKJKKK%KKKKIKKKKK1KKKKDJKKJKK%KKKKKKKKKK+KKKKKKK*KKKKK1KKK2KKKKKKKKKKKAKJKKKKJKKJKKKKKKHKKKKKKKKKKKK8KKGKKKJKKKGKK0KK(KIKKKKKKKKKKKGK%IJKKKKGJKKKKKKKFKKKKKKKKFKKK-KKKKKKK/KKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKK'KKK6KJKJKKJKKKK4KFK8KK*KKKKK@K/KKHJKKD=K8KK8KKKJKKKK?KKKKKKHKKK.KKKJKKKKKKKJKKKKKKKKGKKKHK?KKKKKKKJKKKKIKKK?KKKKJKKIHIIDKKKKKKKJKKKKKKKGKKKKKKEKKKKK,KK8KJHKKKKK?KIK?KKK4K'KIK2K-KK.KIKKKKCKKKKKKKKIKKKKK3KKEKK>KK0KKKKBKKKCKKKKKIKKKKKK1KKKKKKHK8KK;K8KKKKKKKK@KKKJKKJKKHKKKFKKKJKKHKKEKHBHJJKHKIKKKKK;JKHJGKHHKCK3IIJKBHJKKHKKJKKKKHKKCKKKKKKKKGGKKIKKKKKKBCKKKJKKKJKKKFKAEKJKKKKKKKKIKKKKKJGKIKBIK@KKKJKEKKFKKBIKDKIKDKKJKK9KK@KJ/FKIIKKKDKJKHJKBKGKKK?KBKKEK:GKKK?KFKKKKKKGKJKKKKAKJJKKKKKHIKKHJCHKKKJKKKJGK>HKKKKHKKBKKHKIIBJIJKJ;KGFKKKKKJKJKKKKHAKKKK6KKFKKHJKKIKKKKEIJCHDJKK@KKKKKKKK:KJJDKAKKKKHHKKBKIJJHHIIIGIJKKJKJKKHKKIKFIKK;JJKJKKKHKK@IKKKKGK=KHJKKKKKKKJKKKEKKKKKIKIJIKKJIKJ@JKG@JKJKKKHJKKK>KKKKJJKKHJIGK4JKAHKKKKKKKJIIDJKIKEKKJKKJKKIKKJKKKKKKKJIKAKKJKIKKKKKK,KKKKK7KKK'HKKEIJEKKKKKIJHHJGJKJIKIKKKGKJHHKKIJKJJKIKKKIKEIIHKKKKHJKCAIHKKJIKKHHFGKKKDHKKIJKKGKKGKKHKKKIKFKKJKKKJKJKKKKEKGKJEKAJJJKIKKJKJKECIKKEJFJJKKIKKKKKGHKJKKCKEFKI?IJJKKKK8KGKKKKKKKKK4KKFJKKKHKK=KKKKKKK@KKKKKKKKKCK=KIKK4KKK6KKKKKAKKJKKKKKKKDKKKIKKKKKKK:KKKKKKJKKDKKK>KKK2KKKKKKKKKKKKKKKKKKKKKKKK5KJKKKKJKKKKFKKKJKKEKKK,KKKKKKKKEKJK4KJKKKKK%KJKKKFKKJKHJKKKJKK,KKKHKK1KIKKKKK8JH4KKKKKKKFKDKK=KKKKEK@KIKIKKKKKHKKKKKJKKKKKKKKK1KKKKCKCKKKK%KKKKKKKBKKKKKKKKKKKI0H&KKKKKKAKKKKKKKKKKIHBEK6KGJKKKKKKKKKKKKKKKKKKKAKK=KK8KKKKKKK,KKKJKKKKKKKKKKKBKKKKKKKKKKKKKK5KKKKKKKKKKKKKKKKKKK$DKKKKKKKKGKKKK3KKK;KKDKKKKKKKKKKKKKKKKK/KKKGKKKKKKJK,K>JKK7KKKKKKDJKKKKKKKKK@@6>;<@<==A>AA;?<;?9@1B:A=>>>CC?9BB;?476;B==<5@;A;?@6?@B494:@@AA>1:=8>C4@:C>?5:0>?CC>?>>.>@><>;@AAC=C@=0=;;@9C;>C===CBA@A7=A@7A>C6<@8/0?:6%8=>=@9@@8:B8:=;05:@=4<.>A@?>>>58?>;>A>=?=>7;>==A;???;;59@::71:=;764:>9?BB3B=643@>:7@0B@?A<>=?BA?5?<>0>97:@BABFBC?=>E8/;=;B@AEAA:@A@==AA@>BD==89>7>.;9189)?@A@8C>:?;FF>AFA9@4/C/DG???BB=>@@EDCGF@C@C:EFE?F?8<>DEC;?5B>E@EBCC@0?>9EEC>EB/:DE;D<5>7:>E2A?EFAFBCDEB7CDEB?;E?E=DF44AEFGDD2DCAC1BEBBFD=EB>GBEGC?=@@A1=>B=(A<=>>)9EA>>CAEDE<3?FA4C><@8>7ED::5=>B;A@BA?D?BBCBF;?4CCCC1=A?=:BA6@:6=:8;4DA@A:;EAF;?@/;@;A>>4?:::>>8?:=8:A<@;9<88>,@@E>B?7DFAEF52>E=C8C@ADA85BCEE;>=>@EC:7<+;9.D94?>?CC;3::71%:555;=>@61A>5>>?B;?81=7*<9@@<9=??==0>>8>7B@AA<=D<::;?BD8;;<=FE;==?CDCC9D;;A*B@?0D>>@?BC)C@F?;ECBD59ECA;EDCEDEEF;GECDEEFCC5C=C8=+>96?CC4A>@4A>A=;>A??;A:=5,5AC<;C=4?=A<:6A@C9?;@AD>C9@:9A:DAB?CDB==D>FDCBDB@D?@E>DD??>@CCEC@AE;C?E>EGCGEBGFG@EA?FFEF>CGE?EEBB=>950=<<@?CC7AFC;?C7=AED5>+BAD;:>EF<@<;BE=CBA>@=?AC7>=7??9<6B<@>BADCACB@AE=-B:3;:;:7=C<=C@9<:?8AA@@>@1?9?=A07:<.0,2@@+67.?527@5:>A@?4B@B59'9EC=DE?>FCC?@BE7D;BADA=B@AC?@BA@DEED=27;9<;D;CEE:E9EGEDFAF?D@?DB>&?9=?:8AFCAF=1ACD:E?BB8:*B@D9F:E?@B@C7BE>A2?>CFGCB@AB;EBAC;>B/BC<:G@FEBC4C?C@DF=A:@:==AEC?;;>@'DEB<9;D?E@=?8E>=GC?:@FC@C%>BFC=?4EGEE?CE9BB4E?9FE6DA>@@7=?A;@;5DBDC9?BB14<.<)<=5A;2>8:?=>>5B967:695?0?A?;?<<@=>@?;<7>?87>3;?@A6:A>6:<:/;=8=;4>2?2:<=B=D=?A77@;@CAA<<=;<;=*?>?@<*A;?<7908;7>@E==E0@EAADDD@@B;AD@EEA?D4BA>C3BGC@@?E?@FCBCCC*EB>9B?BAA;:;54<+74?:58BD1D@30@B9;=:;?=A4A4?=2;3=>?@CEAADB5G>D4<:76=DEB::CC:EGGGAGDF=GI?GFEC6F@BBGHH:IIGBD6EID;E4IFIE>A2G?FFB?A=7=9A=EDCE??>;?;DCED-F5F2AEEE@9BCDEDA<8;=79>>9>ADABAA@3C=CFD?>?;@;FBA@EDA6>@<;C1>C9@B=D;9=?GCCC?C6ADABFCBFF>:AB=>>E:?@4BD7@/C?AAAEDBEB;=C;ABF@?EAEGEBDE3EB@:39A:A>?@=?A53BD@C>BB;*@=BAAE?<6>@EC?@>8:F@CFB=EDB>:A7;;3:F?EFE3BFB@@GFEECCCC;';BEB@-;78>=6>4=;@B>8849?? @rCer/2488/25_2375_CCS ATGGGATCACGCTCCGGCGCGCTTCTCGGGGAGGCTTGGACCGACGCGGCCCAGCCAGGAACATTCCGTGCGTGGACCAGCCGGTCGGGCGATGCGCGGCTGCGGTGTCTGCGCGGTGGAGCCGCGGCGCCGAGGCGGTGCACTACATCGGGTCTCGGCTTGGACGAACCTTGACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAGGCAGCTACGGCTTCCTCCCGGAACTCCTTTGCAGCTGACGACAAGGCCACTGAACCTCTGCCCAAGGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTGGGCAGAGCAGAAATGCCTGTGTTCCGCCGTTCACCATCGAGGTGAAGGCCAACACATATGAAAAGTACTGGCCATTTTACCAGAAGCATGGGGGCATATTTTCCCAAAGATCATTGAAAAAGGCTGTTACTGAAATTGAAGAAATGTGCAATATTTAAAAATGGAAGGAGTGACAGTGAGGAGGCCTGACCCCATTGACTGGTTCATTGAAGTATAAACTCCTGATTTTGAGTCTACGGGTTTATACAGTGCAATGCCTTCGAGACATCCTGATAGTTGTGGGCAATGAGATTATCGAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATCAAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCACAATGGCTGATGAGCTTTATGACCGGGATTATCCCATCCACTCTGTAGAAGACAGACACAAATTGGCTGCTCAGGGAAAATTTGTGACAACTGAGTTTGAGCATGCTTTGATGCTGCTGACTTCTTCGAGCTGGAAAAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGGCATTGAATGGATGCGTAGGCATCTTTGCTCCAGATTACAGAGTACATATCATCTCCTTTAAAGATCCAATCCCATGCATATTGATGCTACTTCAACATCATTGGACCTGGTACTGTGCTTTCCAACCCTGACCGACCATGTCACCAGATTGATCTTTTCAAGAAAAGCAGGATGGACTATCATTACTCCTCAACACCAATCATCCCAGACGATCATCCACTCTGGAGTCATCCAAATGGCTTTCCATGAATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTTCCAACTCAAAAGATGTTTGAAAAGCTGGGTATTCACTACCATTAAAGTTTAACTTCGTAATGCCAATTCCCTGGGAGGAGGCTTCCACTGCTGGACTGCGATGTCCGGCGCCGAGGCACCTGCAGTCCTACTTGGACTGAACAGGCCTGATGAGCTTGTGGCTGGCCTCAGATACACCTAAGAAGCTTAGGGGCAAGGTTCATTATCCTGCTTTGAAAAGTGCATGAACTGTAGTGCTTTTAACACAATCATCTCCTTAACACAGGGGTTCGTAAGCCTGGTTTGCTTCTATTACTTTTCTTTGACATAAAGAAATAACTTCTGCTAGGTATTACTCTCTACTCCTAAAGTTATTTTACTATTTTGGCTTCAAGTATAAAATTTTGGTGATGTGTACCAAGACAAAATTAGTCACCTGAGTAACTTGGCCACTAATTAATTAACCATCTACCTCTGTTTTTAATTTTCTTTCCAAAAGGCAGCTTGAAATGTTGGTCCTAATCTTAATTTTTTTTCCTTTTCTATAAGACTTGAGAATGTTTTTCTCTAAATGGAGAGAAAGACTTAGAATGTACACAGATCCTAAATAGAATCAGATAATCTCTTTTTTTTATAAAGGAGAGAAAGACTTAGAACAACACGGATCCTAAGTAGAACAGGTAATTGTCTCTTTCTAATAAGGAATTTGGGGTAATTTTTAATTTTTTTGTTTTTTAAAAAATAACCTAGACTATGCAAAACATCAAAGTGAATTTTCCATGAATGTTTTTTAATATTCTCATCTCAACATTGTGATATATGCTACTAAAAACCTTTTCATATACATCTTACCTCTTTCAAGTGAATTATTTTAATCTTTTCCTCTCTTTTCCAAAAATTTACAGGAATGTTTAGTGTAATTGGAGTTTCGCTATCAGTTCCCATCCTCTAAGTTTTGTAAAGTATTCAATATCTGATAGATACACTGCATCTTTGGTAATCTAAGATTTGTTTACAAATGTGCAAATTATTTACAGCATGACTTTATAAGCATTAAAAAAAAACTAATGGAGGTAAAACCTATATGCGATGTGAAATAAATTTTAGTGTTGATACTGTATGTGTATTTTTATTCTAATAAACTTTTGTGTTCCAGACT + (,%,*),),,--,*-)-())-,$&),*+-..,,.-,,(-(*----))+-,-,+$(+--.-.,(%+),-,--)((--),(+&(#'(,),,+))+(&$('*,))&%*'(+,(*+--),*#*&+',,),.-,&*+,(-+)+))))*'$+)),-*.*--,,.+*+')'),-.+.-.+(*$+,%)%+**-''++().*$+)(+)*---,&(,),.,(,-,--&,,)-+.-+.,'(#+'&'(,-*-++--+',)$$%$)*,)-----'*'.-+--(--&&'((,(*&-,+))-)++.-,.-,&*+(')*&--,&,+-)+*))',,.--,(&*+$&*,++-,--))'--)+))((%)#)%,)()((-+)+),(+)*+.,,),,.),')(,**$'%+),*+-+$+,'-*-,',()&&+()()'*-+((#-++%#%(,--'*-,-,,---,)-,(---,'*+---.-'#(,--)+)&+*&++*,)(+),,+',+#'(+*+-.,))()+,--,((+*(*,*(.)++'&$-,,,%+'(,-(.&)),&+-(*(,(&&&+,,(+*(+&--,(,,&(')('-)$'(&%$'),(,-,-*,$%$'()(%'())%%%(')((%''($$%&())(%('#%%')&)()((())&%&)$##')#(()(%(%$&)%&)(%''(%$('()))(('%%&(%'(&&%')'&(%&&&&'(&&)(&)(%&((&$%()#$$%&$$((()()()&#&%"'&'%)(#&'((%(%'('%(((((&()%((%()(#$&$%((('(((((%&(%(''('%'%%&#&##%%('')(''(())#('%%')'(&%$%&)(&%%#%&'(('(&((%))(%()))($$'(%$('"&'(%(''%'&))))(&(&))))(((%('((')('))()$('($(%$&(%((((('%$%(#%(%(()))(%$$((%('&))'$%&'(((%('(#$$%('%#$$&%$$&(()&))'))((($(')($'&'('('%'')))()(%'##'(%((''$%%(')($(())(%('%%('#'(%'%'%&$((%%)''%('&%(&%&(())())(%&%('('())&)(%))'$'#(()(()((('%)'($')($$&((&%&)#%$(())()(&%'))(&(((&)(&()'#((%(((&)))()()))()(%'$%%'%%%(%(()'())''(#'(&$$%'&&&)(%%$')&((()()'#')($('((%('&'#'('()((%(('#'(&$%)('))(%''(''(%($%''))%$'$$'##))'$&(((%(()((())%&)'%())')('&%)((()('&)'%'&(&&)((((%'$(%(('%)'$#&'%&(()()%')()$&(('%')(%%(()'$%&$&(%$(()()(%')()'(%&&&%&$%)%$((&)(%'))()))%&)%'&)'(')('#'''($'&(()))))))(%%$&'()()())(#'''&%$(%'))'#%$'()'(#(&))(%('$#%&(%%''()(%'#(()((&'(&(&%'%(()'#'(())((%''&#&%(')'(($()'(()))))))(&'#&(%#$')(%)))()$#''&'('#$('&()%()($((((($''&&)))()$'%'(&((%&)#&((&#(((%)'%&%'(&'%'(%#''%(')$((&)'(%'')))%'$('%('%$(((''$((('()')))(()'%&&))(&)($(&#''$((()'(&&'$%$')%''&()()))))))()()))))(&"$##$"%$'(&(#%&))))($$'%('(#%'&'$$$%'%((%%(&)((%%&)))()(&)(%'%%$%$(&($''%%(%'('%)))))))'(%'&&)%'%&#%%&%$$&%&%('$%&&)()%&()(%((%('#%#'')(()(('&%&(%((()()(%(()))%'($&($$&(%'(&(')&)))())'$'((((()))))(%(&)')*-,+,--++.-,(+*,&+++,--.(----.)--,)$&''&())())($+&(&&%$'*&)()'()+,&',((')&*(,)%)+*+(,)...,(&),+),,,*,*$(('#'--,)),,(,())((,*(--,(-,(),(%()"$&*(,'-+')%(&+)++,%,+'('),,''(&+*,)&#"####&'#$''&&&'#&%#$$'%$$&&&#$"%$$"""#"$$%"#%#%&'''(+--+#+,)))(*+++-..-.-,-)+-)--,&+,'&,++($*,---,-,**+,'%,-(+,*$*)#,((-,,,,.*,-+.%*,,,,++,,)(+,,-*)-+&,++''+-)&+,(+,,-,-+,,'$$)(&),&$&&%''$+%(*,,&$&)(&'+..,,+')+---*'-,,%,-(((,-.-.-,-,( @rCer/2489/2058_55_CCS ATGGGGGCTGCTGGGCGGTGACTGGCCCAGCCGCACCGCGTCTCCCGCGGTCTCTGCAGCCCCGCAGGCCCCGGCCCTCTCATTCTCAGCGCTGCCCTGTCTTGGGTTCCAGTGTTCCAGCTTCTGCGAGATGACGCTCAAGGCGAGCGAGGGCGAGAGTGGAGGCAGCATGCACACGGCGCTCTCCGACCTCTACCTGGAGCACTTGCTGCAGAAGCGTAGTCGGCCAGAGGCTGTATCGCATCCATTGAATACTGTGACCGAGGACATGTACACCAACGGGTCTCCTGCCCCAGGTAGCCCTGCCCAAGTCAAGGGACAGAGGTGCGGAAAGTGCGACTCATACAGATTGAGAAGGTCACAGAGGAGCCCATGGGAATCACTCTGAAGCTGAATGAAAAACAGTCCTGTACAGTGGCCAGAATTCTTCACGGTGGCATGATCCATAGACAAGGCTCTCTTCACGTGGGGATGAGATCCTAGAAATCAATGGCACAAATGTGACTAATCATTCAGTGGATCAGCTGCAGAAGGCGATGAAAGAACCAAAGGAATGATCTCATTAAAAGTAATTCCCAACCAGCAAAGCCGTCTTCCTGCACTACAGATGTTCATGAGAGCGCAGTTTGACTATGATCCAAAAAGGACAACCTGATCCCTTGCAAGGAGGCGGGACTGAAGTTTGCTACTGGGGACATTATCCAGATTATCAACAAGGATGACAGCAATTGGTGGCAGGGACGGGTGGAAGGCTCCTCCAAGGAGTCAGCAGGATTGATCCCTTCCCCTGAACTGCAGGAATGGCGAGTGGCAAGTATAGCTCAGTCAGCTCCTAGCGAAGCCCCGAGCTGCAGTCCCTTTGGGAAGAAGAAGAAGTACAAAGACAAATATCTGGCCAAGCACAGCTCGATTTTTGATCAGTTGGATGTTGTTTCCTACGAGGAAGTCGTTCGGCTCCCTGCATTCAAGAGGAAGACCCTGGTGCTGATCGGAGCCAGTGGGTGGGTCGCAGCCACATTAAGAATGCCCTGCTCAGCCAGAATCCGGAGAAGTTTGTGTACCCTGCCCATATACAACACGGCCGCCAAGGAAGAGTGAGGAAGATGGGAAGGAGTACCACTTTATCTCAACAGAGGAGATGACAAGGAACATCTCTGCCAATGAGTTCTTGGAGTTTGGCAGCTACCAAGGCAACATGTTTGGCACCAAATTTGAAACAGTGCACCAGATTCATAAGCAAGACAAGATTGCCATCCTTGACATTGAGCCCAGACCCTGAAAATTGTTCGGACAGCAGAACTTTCACCTTTCATTGTATTCATTGCACCTACTGACCAGGCACTCAGACAGAAGCCCTGCAGCAGCTGCAGAAGGACTCTGAGGCCATCCGCAGCCAGTACGCTCACTACTTTGACCTCTCACTGGTCAATAATAGTGTTGATGAAACCCTTAAGAAATTACAAGAAGCCTTCGACCAAGCGTGCAGTTCTCCACAGTGGGTGCCTGTCTCCTGGGTTTACTAAGCTCATAGAATGGGGGAACCCACTGTATGCCCTCTCCAGCATTTGGAACTCCACCCCCCTTGCTTTAAGACAAACAGGGCTGCTCCAACTAGTTTTGTGTCAGCTTCCAGCTCTCTGCAGCTATCCTAATTAAGCCAGTAGGTTCAGTCTTCTTGCTCAGGCTCCTGAAGGGTTGGGATTTGATTTTCCTAATAGATGGGGCCCCAGTAATCTGGATTTCAAAAGGATTTCTAGAAATTGGGGGTAAGCAGTACTACCAAAACATAACTGCTAGATCAAGGATGATGCACAGCAAAAGCAACGACCCATCCTCTAAAGCCTGCCCTCCTTTGCCTTCAACTGTATCTCGTTTGTCTTTTTATTTTGGAGAAAGCGTTTTTAACTGCAACTTTCTATAATGCCAAAATGACACATCTGTGCAATAGAATGACGTCTGCTCTAGGGAAACCTTCAAAAGCAATAAAAATGCTGTGTTAAAAT + AFGGCC-3EG>C?@AFG:@C%<8D2A?FFCD?A:FGE?EEED>@BCA:AC;E;BFDCB?B@=/DA>;?B>C1>G9?CFA@>CFC,=CG7FFD?>?=<@?D?FE@5@63G:/:E9=A?FEB@<=7A9=@C1G5B>B=%>6;7A@CB94BG@AA5?E.;=C:EC@@B=BAC:<7:<4;*48E-@>CCB6=BB;7@:EDF;CC2;6CDF24@EB*B=::BE;ED;3.5$9=>>9@F>?<=C=?;D=C7?C:@C=BC=D0BG6C?@8;CC=ADCFCDF=E?CFECDGAC@;DDB@52CEFA=?EE*A;ECB%EFGEDF?EEEFF?FBBFD@BF:@;>B>?BB&B><6D;AB0F8G@BDA=C/EG9C@??E@2B4=C?DFFDEC@E=>AD;ED@A5@4D?A$-FCF.B1@<=&:8>9F@GE@EDDBE8E'CE7>?C(BBFFGE@=A4D@AE,>?DGDCEGEBF=GECFEC1DGA;4ECD=B4ADFAD>D;BE5BAF@3>>>@5EE:GAD-AAGA7EBC?EDBGDEG<>=5ACE.E@><@?>BBC1:=AFB?A>8@/@?CB=C9AFGF3EC>;D@BA?FED=>D:FD?C>?C<>B>?A9A@CEGGAFCC>?5B=FECC1B8GDAEBF@AFFE=;?C=:+7<@ECAB9C8A?;@:EFG=C5=;CBEE>C+DF?ADFE<=CAADCD;>AA=@BEF5CBD@;E3FCA=>(=FDEEFFACBFDCFGCEFED?EG7GFE>==C?B0@DGDC@C9F>DE=>E4>9CD5D0>;B;DD,BG?>CD;FFD?EE:D?G3?>DFA;BD6@C:E>4>DFFBE7?A&8@EDCC3ED:BE@8ED7>9:9B@AE@@DE@AE??8?C:D@BAF2G>>AEDD=?D5B=C9;C@A>=?=B7;>3<@8?AB@A=+>?>3@3,6@;6=7=ABA.@>@?8=:2:C4;@A:CC9==>:>/@-?B4BB?=?99?@?&;>?@BA?;>AA:;8?7:9:55-6777';2855<1>7:3:<=2>9??6:=<8<==97;:77<<<.<>=>>=:>>9?;4038989;2>=;:5;9=9<=5>::,8=08881;':59;1:6?9=;0:99=:8868909>=:>>9929:,86>7,2;::$65;=799;;9:9:.9==58<0=3=<<4,67;,6>==2:2366.8718==0?98966%;?984:725>9650:?=0>><9<=8-1:1:>25;27-.41;798:;83<><9+8=;>>=47;,:7=+176:=;<6,<;:>2:>7=?7=1>=>??;8==>><915=<75536767055+458;.;683:7<,/99-;::=9:=7<6;<9*7>=2:187;:;3/84%*137'6.648/15:4;=9;=;)==+*#<,:;<6*133.628::%0==8450>'9??67 @rCer/2491/2018_59_CCS ATGGGAGTTCCGTCGCAGCCGGGAGTGGGATCGCAGTTCTTGTTTGTGTGTCGGTGTCATCGCCACTTGACAATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTTGAGGTTGAGCCCAGTGACACCATTGAGAATGTCAAGGCAAAGATCCAAGATAAGGAAGGCATTCTCCCGACCAGCAGAGGCTGATCTTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTCGAGCCAGTGACACCATCGAGAACGTCAAAGCAAAGATCCAAGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCTACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGTGACACCATCGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATTCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTCGAGGTGGAGCCCAGTGACACTATTGAAAATGTCAAGGCAAAGATCCAGGACAAGGAGGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTCGAGGTGGAGCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGATAAGGAAGGCATCCCGCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCTGCACCTCGTGCTCCGCCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTCACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGCGACACCATTGAGAATGTCAAGGCAAAGATCCAGGACAAGGAAGGCATCCTCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACTCTGCACTTGGTCCTGCGCTTGAGGGGGGGTGTCTAAGTTTCCCCTTTTAAGGTTTCAACAAATTTCATTGCACTTTTCTTTCAATAAAGTTGTTGCATTCC + D?C=*99C==@E8E>@A1B9D?=;:;EE@B99?:<:F>C8==EE@D1=FABCA@>5>E@?@5DDGCEA6EB;<;AF27=5A*C(A:66DG>>A=8AA7>)A?EBD;;FDBC'EADEC>E?A?D0E=;DC>E>=D6;8CBA3@;C<)C5$09B7A>;:6A@;8=C<9=<5;588,=@;;BB?8B1>B4;@4<95266>>;>968;4267:?;@><8:;56:<5<=41-9846517=A4;=;=:=9=A246?:7;1;8=6;?@;@>8=5>351?>9=:<-7/6;:98@60/27;=>;??6?>@=6<35:&@5@:?:9=<3.(7=2;;:<757;:85:8:5;>==<632/2=;/9;2=>:67?:3-4<=>8<6:9;53->>97<0<93688*31:?;=7<:,9;;98;:9<)8>>==29;2299;877=7;98>;?7989+7699:6237;88>>9;:79?7;>:?=>>08=7>;<.>6;88:+2873<04=;:><:2>:=8>:9932:9>9<=5:<355(4'89;3>:;=;:?9=;?0?:=0;,8593:29=8>:;?:;9>;;969:47;=56<2>?9?>?=9:6=:42=5=8>;>?;9>>7;994>?>890==7<9?19>=:38>=:*<97<=726=08:63:97?8:>:437232<1:<8=3=??8:<>456/2:;;>:6:87919?19;266;0==+56?93;>>:9-<;=835765857&6?99>;:824=17625,9'8>?7=5:69465:?9:?759?=;>8??/960<;*9;5<4:;6;5<895>192<78?;<=:<>;7:;6?;5;:>=>=2:6:95>><45;95>9>;;>==<,;=>49:9??>;6:49<28798:6632=;;::;8;55<>/9'4'5::66<;:728339:;908,-1/2)9;><683;7;:;;84:;::.=>91;<<,<::62:687=70==;<)>:><;,:;>==4>;:;9=:9::?9?<4;=(9;8::14=9;>7=9>?>;54>177>;91>>=3<=.8<5*89>4?:>:;8<*4<;8=:+8999=:99:8;;0=;:?94>??=><:=;88<<1;>;2;86<91;9;5:7$99984:3::8<94;<9>=?>9?9/8;999;<;3;=>>,19;77:67;8*8=;;>88;<:54$9==6>>6:1==.<:>787:3;=;28:9;9>=>;:9+68:;<1:>6>8>9;95?9:;=?;079=9==<==87=569736:5<46?>;:786:<7=:8:?=4547<85299;:<;?9<=-=>9;:9.=??;8:31)3276;96;9=;;>=761834-7=0:=7:9=>;862>;67:==5:9=,84:?999;72;<==>4;;71=59916;8=9;<9(:=9:6;?<6>?3=8:3=82:>??199,96>=2/22:8;<<=.=;=.=;490>=;;6:8>5248+:;3958563-3/1<9:7:<9826?:9849364:9:869$0<;>;;94:299577>:2878*7;2.<<)=:99:;9.5<3956;;87>=57>>=8<;2>?92:?63:>789(<,;==9;?=>=>=/36<:<99?98:3:=9;<6=<:>853/97/2><:18=5=:;99/>79:?<67&'$8::5+7:=9>=>9<=73=;7:7:>;?:8:>1>><=3922.==>=92:>9:;?8:58>>98890;83959<:;4:?8<4><6-;781>8:51<,>8>?<6=6;9?><;949<87&9><7=;467=-;:5/=<;9968;;=+;??8:=47:9866,::9833?:<= @rCer/2492/180_86_CCS CGTGTTTCTGTCAGTCCATGACATAGCTCAAATACCTATCTGTTTTTATGAGCAGAAGGGGTAAAACTAATAAAAACAAGACTGTATTACGTAG + $$*'&'(.)))'$%'#+)++/-.*,***).'*++,.+(+')++%&*&.*-.,-+,--)&'$,.**-(#/.+)')(()+.+',-+*%-'*+-('+ @rCer/2493/2748_55_CCS ATGGGGACTGGTCGAGATGGCGGCGGAGCGACAGGAGGCGCTGAGGGAGTTCGTGGCGGTGACGGCGCCGAGGAGGAGCGGGCCCGCTTCTTTCTGGAGTCGGCCGGCTGGACTTGCAGATCGCGCTAGCGAGCTTTATGAGGACGGAGGGATGAAGACATTGTGACCATTTCGCAGGCAACCCCCAGTTCAGTGTCCAGAGGCACAGCCCCCAGTGATAATAGAGTGACATCCTTCAGAGACCTCATTCATGACCAAGATGAGGATGAGGAAGAGGAGGAAGGCCAGAGGAGCAGGTTTTATGCTGGGGGGCTCAGAGAGAAGTGGACAGCAGATTGTTGCCCTCCCAGGAAGAAAAGTCCCAACGAGCTGGTGGATGATCTCTTTAAAGTGCCAAAGAGCATGGAGCTGTAGCTGTGGAGCGAGTGACCAAGAGCCCTGGAGAGACCAGTAAACGAGACCATTTGCAGGAGGTGGCTACCGCTTGGGGCAGCACCAGAGGAAGAGTCTGCCTATGTGGCAGGAGAAAAGAGGCAGCATTCCAGCCAAGATGTTCATGTAGTATTGAAACTCTGGAAGAGTGGATTCAGCCTGGATAATGGAGAACTCAGAAGCTACCAAGATCCATCCAATGCCCAGTTTCTGGAGTCTATCCGCAGAGGGGAGGTGCAGCAGAGCTGCGGAGGCTAGCTCACGGTGGACAGGTGAATTTGGATATGGAGGACCATCGGGACGAGGACTTTGTGAAGCCCAAAGGAGCCTTCAAAGCCTTCACTGGCGAGGGTCAGAAACTAGGCAGCACTGCCCCCAGGTGTTGAGTACCAGCTCTCCAGCCCAACAGGCAGAAATGAAGCAAAGCCAGCTCTTCCATCTTAATCGACGAATCAGAGCCTACCACAAACATCCAAATTCGGCTTGCAGACGGCGGGAGGCTGGTGCAGAAATTTAACCACAGCCACAGGATCAGCGACATCCGACTCTTCATCGTGGATGCCCGGCCAGCCATGGCTGCCACCAGCTTTATCCTCATGACTACTTTCCCGAACAAAGAGCTGGCTGATGAGAGCCAGACCTGAAGGAAGCCAACCTGCTCAATGCTGTCATCGTGCAGCGGTTAACATAACCGCCCAGCCAGCTGCCTGGCATCCCTCCTGTGTTTCCATGGCCAGTGGCCATGCGGATCGCCCCTCCTGCCCCCTTGTGCACACCCAGCAGTCCAGTGCGACCGTCTCCTCATAGCTCTGGGTTCTTAGATCTTGGTTGGACATTTGTTTTCTCCTTAGTTGCATTTCCTGGGTTTTTGTGACGATCAATGGACTTTAATGAAAAAAAAATAAAAACAACCAAAAAAATTGAAGGAATATCACCAGCATGTTGTACGGAAACTCTCCCACTGAAGCAGGCTTTAATTGCTTTAAAATTATATTTATCTTGGGGCTGTGGGAGGAAACTTCCTTCCATCTTCTCTACATAAAAACTTGTGGCACACAAGGCTTATTCACTAGTGTGTCCCACCTGCCAGCCCCAACGATCACTGGAGGAAGGAGGGGAAATGTGTTGAAAGAGGCTTTGCCACCACTCGTTCCCACGAGAATATATCACTTGCCCAGATAAAACTGGGCAGCAGCCAGAGTCCCCTAAAAGTGGGAAGTCAGAGCTACATGCACACAGTGTCTTCAGAAGGTGAAAATAAATACTTCCCTGTGCTCCTTTTACTCAACCCCTGGGAAATCCAATCTTGCCAGGCCTTGGCCAGTTGAGATTCTGTTCCACCTGCCTGCCTGGCCCTTTCCTCCGTCACCATCCAGACTGCTCACCTCCTGGGTATTCTTATGGGCTCCTTTATGGTTTGATTTCCTCCACGTGCAGAAGTCTTGAGTGGACCTAGGAGGTAGGTGGGGTATTTTTTTCACTAGGATACAGCTCATGCCAACCCACCCAAGTGAGTTCAGAATCAGGGTATCTTGCCCTAAAAGATAAACAGTCAAAATGCCACCCAGCTGTTCACTAGTGATGTGTGGCAAATCAAATCAACTGTTGAAGAAGGGGTGAGTTTTCCTGTGCTACAAGCATCTGTCACTGTTGGTACGTGCAGGAGGCTTCTGCTGGGTATGTTTTGGAAGTGAGTGTCACTACTTGGCTTTGCTTAGCAGATTCTGCTTCACAGTTGTTCTTTGACCTGCTGACTTGTGACTTGCAGAAACATAGGCAGTAGTCCTAGCCTGGTAAAGACCCTCCATCACCCTCATAAGTTTGCTTCCTATGCAGGTTTTGGGAGAGGAGGCCCATTGGGCTCTTGGATGGAATCCTTTCCCCTATTAAACAAACCAGAGACTTAGAATCAGTGCTGACTCAGGATCTCCTGGTTTGGAATCGTAATGTGCCTCGATCCTCTTTCCAAGCAGGCCTCACCAGTCTTTCTGTTTCCTGCTTCACCCCTGCAATGAGCCAAGAACCACACTACATCCACCTAGAACTGCAGAAGGGCTTTGTGGTTTCAACCAAGACCCATCCTGAGCAAGGGACTTGGCTTTGGTGCTTTTGATCCCAAAGTTCCACACTGACAGTGACCTGCTGGGGCAATGGCATCTGTCATGGTGTTTTCTCCAGCAGGTGGAGATTACTATGGAACCTACATATGGTCTGGAAAAAACTGTACACTGTTGTCACCTTGAACATTAAAAACCAGAATG + -,''+#)1/2/010&-.-+%0,'-/((*10-0..+.,&/1.11121-102/1.00%+*,-+1.-&//1*.+2/.0.0)*-0*2-/10,-112-+.2011102/.%-%0/-$-/,'--+&1-*/-+/10,,11,)*,#,'/0/'.11-011%+.,1.0,/*--0,*02,-0/'+/0/.,,20.**+&102/111110210112,,+/*00//.&-111-+0,*)+/,.0.%)/21//10.10.2/1--2.11-.+2121*)-1../10+)-&00012,12.,,*$*(,#)-(+/,/1-011'.00-+)'##'#*,).000-01--1.-10-1011-0).)##+0)++0./1,2-11.-)...1+1,1011(121/.(1.012111/.,00'$+,201.)-+&*'+0+++/*/11.-11/0(.10/)-1,+.-211.,12-121.*&,0.&11102*%/-**201/200100'.211.,+).20-$-)(-,%-11+))%,.+..21,/,-*)12/*12..2.11+110/.+'.('$/,0.(.--&112,0+*/./0*1-+0..1'-0),-1',-.,2/1-..011,01,.,/0)01*0/20--,10-,-11100+/10)0/2110.1,-,0.)1110.&/,02)111-....+.-/,/--'-0.+'/.*//&011.-.&01,--,.-%,-*./,-,..%(-.1112.1.++10*0+)01.20-,'1/1101//%-1.,/(-.2211/101122/2/12..00..+*12///&1.&&%..(.,../*01/.11,0+/0++*-'+1111212*/1.10-(/-/(+-&00(1112-0+-/'*(-/211-/0-&0./0/&'.&'2/1,10'2/1)$)&2)--*1.)%.0,0-10.,0,'10100+,&.,/1.2200-12.--&01-11.2-02.,01+10-+**+'010+1,//+0101/0.'*-,/,111.,1-111-/+/1,/1011/10-,20(-.//&2.0/*/-&112.0,.2011--112211121111.,-/.0+01',1,10--22,01110+-.1.+/11110/'01.,$*121211-/1-1,.+-.+11.1/1/(+)0-0.,000,1.0*212111-*).112.-'*/((+/110&.,&..,-1-11+..-.01+/&000+,+,110.21111/2.'**//12*,0+*-'/.)'211111/1-0+-/.10+$,*.110-0)($(.+$+--&/111.1/'22/0'/)*+111121/.1-20,01220,/-/&-1+-11.1210)/1.)21121-111.)-1/-10--11*-*./.22..(10101-1111))&-//%&2.0,/////.%1.+101(0-0/,-/-,01101121/+01011,)+.1/+/&-*100..1.00,11,2/0,0121,120,/1...+'#)+.-(-(1)%+0*11+,1,2211/.0/1+201('.,,.11-)-*000/&*1..1--01,-12.2112-.211110'+,,(*()0)0/.1/1)-0011(/,,,+1..*12112...2,01/0*.*%%%,,**1020/(2/.-2.00,+0+-.,1.2100'110-02.0/1++0-100/.0&.21,,10)0-),'01-1..2+0.,-/22/..202.0-0-,0+/11/*')/&0..$*+-+...11..,1./--+(1*0122.1-11,-100-11-11+0,0-+,,/&..--1,0++)-0,'01-/21...1/0.0+-*'.)/-1-20112111.021111002/1*1110.1.-0/2-.1+/-)-*'//-1/-0.,/2.-+00111-,/0*,2/.11-/...,2/0/2.-,01-0//.,0,1.*1022.-'121/--/1,.01+/1.21.-112---)()+'*,+')-+-+-*+....-11.)-.-110+)'.1121.-,,//.0-2-+'01(0,/,)..1..,+-),11.-/.01-00./20,1/,&+),.1--.11,..0(/*)%&-,,/01,-.-0011-.+1/.1///,0/10-112)+0.0+/-+0,0..00&100*,01.--)%.**..110-.,'-1111.11-*,*++,,'*.,001-,0+,.0+1)1.011.+-)'-+--,&-%,'/-0-1.1-1+,1.12020110-,+0)+,,0+,0)(-00---.1-,1*01+1/211.1.101,.11-+-.11001-,-,10..0-/-%,-.1.0-1+*000(00,,22/0-20-.0,+,0-10-1/'-1./,+'+-2/1-1/$0010)+..%0.(//1--0.,10*.2/,/&1.,20..+1,10.-/(./%'-+&0..&00&022,(&00*-)*+(%)),1010-1.(1.11-,2/0,(,0&+,(0.'2--,-+/*)-$(&*0'.().),-(--.),,.--.--(*'*(*2.++0-0/,*&*01)2/).+0---/11--112-011,+%)&()'1,$./,)///1210/*+/120++-.*0+/01*../&.-2+01)0/*)'1//))*%0-0.11.,00,/)%*.-%1.0//%/'-/01,,**.0220,.,12,/(10+0,&)/-+)+..,+..,-./-.,1-21/,,0/.1.0'+(*1.-0+---+,-./+'/2/.)02.110-1/,2+-)0/**/0)'%,112.+-///%/-0.1-+'0.01/$-'1,2/-,+/1212121-2-,02.,/ @rCer/2495/1883_59_CCS ATGGGGAGTGCCCTCGTCCCCCGCAGTCTCTGTGCGTTGAAGCCGGAGACCGCGGCGGCCTCAGCGAGGACCCTTCGCCCCGGAGCCGCCGGCCGGGACCGCAGCCTCTGCCGCAGCGCCCCCACCACCTGTCCCCTCCCCCGCCGCCTCCGCCGGAGCCGCCTCGCGCACTCTGGGGTATGGCCGTCAATGTGTACTCCACATCTGTGACCAGTGAAAATCTGAGTCGCCATGATATGCTTGCATGGGTCAACGACTCCCTGCACCTCAACTATACCAAGATAGAACAGCTCTGTTCAGGGGCAGCCTACTGCCAGTTCATGGACATGCTCTTCCCTGGCTGTGTGCACTTGAGGAAAGTGAAGTTCCAGGCCAAACTAGAGCATGAATACATCCACAACTTCAAGGTGCTGCAAGCAGCTTTCAAGAAGATGGGTGTTGACAAAATCATTCCTGTAGAGAAATTAGTGAAAGGAAAATTCCAAGATAATTTTGAGTTTATTCAGTGGTTTAAGAAATTCTTTGACGCAAACTATGATGGAAAGGATTACAACCCTCTGCTGGCGCGGCAGGGCCAGGACGTAGCGCCACCTCCTAACCCAGTTCCACAGAGGACGTCCCCCACAGGCCCAAAAAACATGCAGACCTCTGGCCGGCTGAGCAACGTGGCCCCCCCCTGCATTCTCCGGAAGAATCCTCCATCAGCCCGAAATGGTGGCCATGAGACTGATGCCCAAATTCTTGAACTCAACCAACAGCTGGTGGACTTGAAGCTGACAGTGGATGGGCTGGAGAAGGAACGTGACTTCTACTTCAGCAAACTTCGTGACATCGAGCTCATCTGCCAGGAGCATGAAAGTGAAAACAGCCCTGTTATCTCAGGCATCATTGGCATCCTCTATGCAACGGAGGAAGGATTCGCACCCCCTGAGGACGATGAGATTGAAGAGCATCAACAAGAAGACCAGGACGAATACTGAGGGCGGCCGCAGCCCTGGCTGACTGCACGGCTTCCCCATGCCTCCCTCCCTGCTCCACTCCCACATTATAGTCCTTTCCTAACACGGTCGGCCGGGTGCTTTGTGTCAGTGCCGCAGCACTGGGGAGCCAGACGAGCGGGGCTTGGGGGCATGGGGCCGGAAAGCAGGCAGAAGCCCGTCCTGGGTGGCGCTGGCCCAGTTGGCGGGACCCCTGTCCACACCCACCCTATTTATTTCTGTTGTCTCTCTGTTGTGTCACCCAACATTTCCCAGGGTGCTGCTGCCACCCGCCCCAGCCAGCCACCTGCTCCCGACAGCTAGCAGCTGTGTATTTGACAAAGTCATTGGTATATTTTTACTTACTGGATTCTCCTTGCACTTTACCTGTTCTTTTCCAGAGCTGACAGCACGGGCTCGGGGCAGTGTGCCTGGCTTGGCTTCCCTTCCCCATGGCTGGGGGCTGGGGCTGGACTCACCCATTCTAATTTATTTTGTCTTTTGGCTTCTCAGTAACTGAGGGGAAGGCTGATGTCAGGAGAGGGAGAGGGGGCTGAGGAGGTAGTGCCGTAGGCCCAGGGGGTCAGGGAGAGGGAGGGGGGCATGTGAGGGATGGAAATGACCTCCTGGCACCAGGCTCACCCACCCAAGGCCCCCTGCCCCAGCACCGAAGCCCACTGCTGCCCTGAGGCCCCCAGCCACTCCCTCCAGCAGCCTGGTTCACCACACAGACTCTGCCTGGACCCCATTGTCTGTCTGCTTCCCACCCGCCCTGCCCACCCCTGCCCCTCAGGCACCAGCCTGCATATGTGTTCACTTTTATTTAAATAAACTTGTGCGGTAAAAG + IIHFD&D@HBHI8?JHIJKKJ6HIKKHJJH>KIJDJJ:=KECHFIEIJEGIIEKDJK@IGFKKKIIH4GIKGJFIJJKJKIKFIKIKKKFGFGG:KJKJKJBKJK4JJJKJHJJKJKJKKKAKHGKIKEKGKKCIKKKFJJK?JJIIJHGKKJKJ2JKKJ@EGKIJJGHKKJGKJKKIKGKKIIKIHKGKJKEKK>IJGIIKFAHJKIKJKKKKEIIKCGKBHK>KIIHIJKIKJKJJKKKK6HCKKFJKJIJJKKIKJKFJDKKHKAKKGHDKKJJJKKKKKKIKIKKKKIKKKDKKIKKK:KKJFHKJJKIJIKJKJDIJJJC?KJKKJKKBKJKKIKK@KJKKKCKJKJKKKKKKBKKKKKGKIKJJKKKJJHCKKKJKKJKJ7FJKK=KJHKKKJKJJKEKKKJKJKKKJKKKKK>KJKDIKFKKKJKKKKDHKKKFKKKKKKKJKKKKKIKKHHEIJKKBKCJJGKKFKKKKKEJKKKI2KHGKKFHGKKKK4KKHJKKKKKGEFKIKKHKKJKJJKHKKKJKKJBKKJKKGKKEJDK8KHKJKKKKCIKKKKKKKKJKKFKJKKJJKGK?KKKHJKKK@KKK?KKKHKKKKKKKK2KJKKKKKKIJKKKK@JKKKKKKKKKKFKKKKIKGKGKKKCKKGKJ;JKKKIAHIKKK>KKKKKJKKKKKKKIKKKKGKKJJFE6AIKJKJKKHKFKJKKK>KKKDD;KKGJKHHKKAGJKKDKIKKIJHKGKKDHJKGKKIKIKKKKKKJIKKKIKKKKKJKJKHJKIJ>GGJKKKKJJHJKHKHKJKKKKCKKJKKKKKJKKIKKJGGK>KKHHKJDFKHKKKGGKJIKKAIJJKJKEHIKHJJJJKKJF:KDKKGGIGKHGJIKKDHFKEKKIKKJGK@KKJKKCKJK@JJHAKKIK=IKKKJKCKKJKJKKJ=KBKKKBIKKKKKJGJEKKKKKK5KKJKKJFKKJK9KKKKJKKKFJEKJKKKK=JKKKKKHF1?KKEGFKKKKFKKKFKHJKCCKKJKIKIKKKIBGKKJ1KEGDKIKJKIJKJKKKJKDIDKKK5JKJKKKEKDKKKKDJEKEKGGCKIKKHHCJKKKBKGKJDKKKKKKKKK7IJKKKJKKIKJFGKJIIFIKGKKHJJK=KJJKKCJKKJKKKJ>JAJKK=JIKKKK;KJCIJIGKKKKKAJKKKDKKKKDKHKKKKK8KKKKJKHKEKJJJKKFJKIKK9KKKKJKKDKJKKGKKEJKJ>JKK>JFJJJAKIKGKDKGKKK=KJKJKKH0 @rCer/2499/24_3704_CCS ATGGGGGAGGCGCGCGGAGCTGGGGGGTCGCCGGTAGCGGTAAGTCCGGCGTGGGTGGAGCCAAGGCTCCGGCCGAGGGGGCGGGAGGGCCAGGAGCAGCCCAGCCGGGGGTGTACGCGACCTACGCTCGCTTCCCAGCCCGACTGTGGCCGCCTGGTCTGGCACCCTTTCTGGACCCTCGGCCTGGCTCCCGCGGTCAAAACCGACTCCAAAGTGTTGGAGGGGTTCCTCTTCCCGGGACGCAGCCTCCCCGGACATGGCAGACGATGCCCCGGTCAGACAGAGCCACTGACCACCCCGCCCACCCCCGAGGCCGGACGCACGGATGCACACCCCGTCCTGGGAGGGACAGGCGCCCTTCCCCTCTGCACCCGCCGGGCCCCCCGCACCCCGCCGAACCCCCCTCCCCCGCCGGCTGCTGGACGTCAGATGCAGCCACCACTAACCCTGGGAGGGACAGACACAAGGACAGGCTCCCCTTCCCCTCTGCACCCTCCTGCTGACTGCAGAACGCCAAATGCAGCCAACACTGACCCTGAGAGGACAGACACACGGACGGTCGCCCCTTCCCCTCCGCACCCCCCTGCTGGCTTACGACCTCAAATGCAGCACACTTGACTTTGGAGGGACAGATACTTTCCAGCCCAGATTGGCCCTGGGGCATGGATAAGATACCCCCTGCACACATGCTGACCCCGGAACTCGAAGATGCCCCTGACTCTAGCCGACCTGCAGCCTGGGCCAGCACCACGCTGCTGCCCTACTGCACCAAAGCCCAAGGATGACAGACTTTCAGCTCTGGAGCCTTGTGATTTCAGCCAGACCCTCATCTGCCCGTTTCAGCCCCAGCACAGCGCTCGGGGCCCCACCTAGACCAAGCTTTGATCCATCCCTGCAGAACAGACCTCTGTCTGGGGATCATGGTTCTGGTCTGGATGAAGTTCTGGGGCCTCTTCCCAGGCCTGAGCAGGCATGGTGGGCTGCTGTGACTAGAACGAGCTGGTTCTGCAGTGGGCATTGAGGTTTGGTCTCACATTGCTTTGCAGGACTGCGGCCTCGATCACATGGACCGGATGCTCCCGGCTGCTCCCTGCTCTCTGTGCTGTTCTGGTAGATCCAGGCAGCCGGTGGCAGATGACACCTGTTTTGGAGAAGCGCTGGACTGTTTAAAACTGGTCACTGAAAGGAGAGTCCAGTCTCGTGCTGCTGCAGGGGAACCCTGCCTGGTGGAGCTGCTGTCTCATGTGCTGAAAGTCCAGGACCTGAGTCCCGGGGTTCTCTCTGTGCAGGAACCTTCGCAGCCCAGGAAAACTGCTTCAGTATCTTCAGCAGGGGGAGTTGCTACCAGGGCTCTTTGGGGAGGCAGGACCCCTCGGCCGAGCAGCCTGGCCGTCCCCACTGTGCGCAGCGGCTGGATCCAGGGCCTACGCTCCCTGGCACAAGCACCCCAGCGCCCTGCGCTTCCTGGCCGACCGACGGTGCGTCGACAACATCTTCTCCCTACAGGGAGACTCCAGCCTGTTTGTGGCCCTCGGCCAGCACAGCTCCTGGTGCACGTCCTGGCTTGTCCATGCGAGGTGGAGCGCGAGGGCACCCCTGCCTGCGGGCAGATGACTTGGCCGTCGTGTGCCCAGAAGATCCCGGATGCATGTGGAGGAGTCCCTGTGCGCACGGCCACCCCAAGGTCATCCAGGCCTGAAAGTCTGACCACGACCTTCGGGCGCTGCCAGAGCCCCTGGACGGAAGCACCTGTGGGTGCGGCTGAGTCCCGCGTGGCCTGTCTGCTGGAGAGAGACCCCATCCCGCCGCACACTCGCTCGTGGACCTGCTTCTCTGTGTGGCTCGTTCTCCTGTGTTCAGTTCTTCTGACGGCGGCCTGTGGGAGACGCTGGCGCAGCTCTGAGCTGCCTGGGTCCCACCCACGTGGGACCCTGGCTTTGGGGATCCTGAAGCTCGAGCAATGCCCACAGGCACGAGGACCCAGGCCTTCCAGGTCCTCCTCACCCCTGGCCTGTGTCCTGAAGGCAACAGTTCAGGCCCCCGACCCCCCAGGCTTGCTGGACGAGACGGCAGACGACTGCCACGACGGTGGACGCGCTCCTGGCCTCCAATCGTCCTGTGCGGGCCTCCTGTGCCGCACCCTTGCTCACCTGGAGGAGCTGCAGCCGCTGCCCCAGCGCCCGTCGCCGTGGCCCAGGCGTCCCTGCTGGGGCTCAGTGACTGTCCTGCGGCTCTGTGATGGCTCGGCTGCTCCCGCCTCCAGCGTGTGGGGAGCCACCTCTGTGGGACTCTGGCGGGCTGCGTCCGGGTCCAGCGAGCAGCCCTCGACTTCCTGGGGACGCTGTCAGAGGGGACGGCCCCCAGGAGTTGGTGACGCAGGCGCTGCTGTCCTCTCGGAGTGCTCGAGAGCCCGGCTCCAGCCCCACGGTTCTGAAGAAGGCCTTCCAGGCCACACTCCAGTGGCTTCTGAGCTCACCAAGACCCCTGGCTGCTCTGATCTTGGCCCCCTCATCCCGCAGTTCCTCAGAGAGCTGTTCCCTGTGCTGCAAGAAACGCCTGTGCCACCCTGCTGGGAGGTGAGGGACTCCGCCCCGAGTTCCGACCCAGCTGAGCAGCACTGGGGAGGACAGGCCGACTTCAGTATGCGCCCTCCTGCTTCAGAGGTGCCTGAGCTGGCCCGCAGCACTCCTCCAGGACCCTGAGAGTACGTCCGAGCGAGCGCAGTGACGCCACGGGGCAACTTTCCAGCCGGGCCTGCACGCCCCCACCACCCTGAGTATGCAGAGGCCCGTGCAGAGCCTGTTCCGGAGCTCCTAACACATTCCTCTCCGTGGACTCGATGGGCTTCCCACGGAAAGGGCGGTCATGCAAGTCTTCACTCGAGTGGCTGCGGGACGGCCACGCTGACGCGGCCAGGAACACGGAGCAGTTCGTGGCCACTGTGCTGCAGGCGGCAATGCCGGGACCTGGACTGGGAGGTCCGCGCCCAGGGCCTGGAGCTGGCGCTGGTGTTCCTGGGCCACCGTGGGCCCGCCACGTACCCACTGCCCCTAAGCTTGGTGCCCTACCGAGGTGGCCCCAGGCCCGGCCACTCACCGAGGCACTGAGGGCTTTCTGCCACGTGGGGCTCTTTGACTCGCCTTTTGCTTGTTTGACTGCGACCGCCCTGTGGCGCAGGAAGTCATGTGAACCTCCTCTTCCTGAGGACAAGATTGCTTCCTACAGCAGCCTGTGGGAGGCCGGGGGCGGCCCCAACACCGCCTCATGGAAGGCCGCGCGAGGTGCCGGACGGGTGAGCATGCCCACCCCAGGGGACCAGGAGCCTGAGGCTTGCTGTGCCATGCTCAGGTCCCTAGATAGGTCGGAGCACACTGGCCGAGAGCAGCGACCACGTGAGAAGAGCCCCAGTCCTCATGCAGGACATGCTGGCCACGGGGGCTTCCTGCAGGGGATGAGGCTGACTGCTACTAAGTAGAACCAGATTCTGCCACTGGGTTCAGGACTGAGGAAGGCAGTGCCACGTCCTTTCGTGGGACACTGCTATCCCCAGGGCTGCAGCCCAGCCAGTGGATCCTCTGGGGAAGCCAGGACCAGGAGAGAAACAAAGTCAAGAAATGCCACATTTTGATGTATTAAAGAAATGACTTATTTTCTACTCAAAATAAATGGCATTGAAGTCT + '($((%$%())')((%(%$#'#('%$&%%%#''))')'%((###"##$%$%%%'("#%%%$$$%#$%$(&%,(,*'&+-+-,%($'+,*,,+(+#&++)%(),($%$,,+&'))+)'#&(,.+,*----+((,(()+)')'$$&--('),-),-'),+--)-+*)*,%+',*(-*&+,&$$&'+-,)&(&'))'&*)(%+,,)----,'&%+*+--*-'-'"#&%%&,-)+*)&,(%)+*&&''(%%*#&*&)-),''*-'&)%%'(',))'*'(*&)(()*---*'-+(,)&&%(+*)*(--,'))*+&+&%#(',(+,-('(,#,-)((&$''*(+((''-+((-*++-&()'%,(&)*,--*-+-++&,+,--('($#%)*+*)*'+*+('(+%$"#(&&&'$%'(%'*+(*,',+,)-(,)+(+---*-)*))-,+%'*&+'-,+$)('&*&()+',-+'%,''*,))-++%,(&$&&*+(+,&++)'*,(')-+---))+)('%&)*,+*,..---))+('--,()--*)((+)(%&($'&(',)((*(("(')++,)--(%*%)((,&,,,+#&%**''+-,(-&$)%&%)(*'()(-+&%(&&%$&)%,%#%),(#''#'&('))*)*&"&)+-(,)*-+&-,*,,'-+(&,*-,(,)((*#$&$&)$%$((($%$%''''#&*(,(++'*-)*,,-*,.-++&'-,)(++,(&+--(++***))*-,(+$(()%'$(''''$)*'+,($($+*'(,'('($)))-,'((&,%)))++,**+,%*,-,,')-,,,$$$&$&*)-*'))'(',-*(($"$'))**'('))($$)'+)'+,+&''$#%*,+(,,&-,-&((,+,,+(++%%#$%+$+,,*(,(&))-*)++**%,*)(%&**(&##&''%)---,--(+)-)'+(-,&'%((*#+&'*%&$*+)&+()'-)-''(,()((*&+,'#&&((,)',,($))*)#',,)+--,*-,%&,%'#(&*-,+))'(,++&(+)+,((%$'#%#%+*&#&&$#,)),+%)&,,)'%)%#$'!$"($&$&'*'(-))$'-,)+.,))-,*('#(%)(),,),,+,--)+'&+*()**')'$)(#$%)('))-'&%'&,+,--+$&(()#**),.--,-&%#'&''(&($$)&$,,)))$)-,),,&$((*,'),())---)+*--)**$('&$%%&#+("#$*$(+&)'+-)()(''+--**+%%**)&$'+--(-*&-(+''(%(%,+),,(,)*)*%!!!!!!!!!!!"#"#$(''(,(&%$$%)'('*(,+',)-)'*##)'($'#')&&)&'))))'''(*'&$"##$'%((&),-(-*(*%('%"#'%'))*,#"$'%#('+((((#&#'(+#%('',)&'*+-*',+(('&&()%(+&$())((,*-+,'')+'&#$&#"&'($&&*%'((%)((+)*&'''&(&-'-)**+")*+()*$!"%%)&"%$&#&$$)$#&'(()*$(*(*%*,(,)+',)+('--)&'#('&"%&'+,%"$"),&())*()(-),)()',,*-(#'$*$('&%)*##'&()))$#$'*$'(###(&')'"&*)'(*)%)&*%,))%$#'$%"$)(&%(+&(*)##($%%##%*+$(#)'&&&(*'('#(,'-*)(&)($(*-+,'-'#&$#$&)*&#$"&$+'$#%&&&&"#$$'+)()#$')&(&&)&$#)&$'&%'))+*'-*(*&*++,)#$%%"$(%"($')),+(-(-,)('%,.+*)&).((&#%((('%#"((,,*'%%&+++*#)+)**,-++','--')$&%%%)(*-**',--,+)))&%-%()%&*,(&*,,)&*-,&'%(%#'$((+'(*+-,(*--,%-,)))--+'),,*%&"&,---+*--,),)**-+''+(',,(*+-)***$-)$).+$+%$('''&%+,-+-,'(,-*,(#"$*$'(,('(*%%*#,(-'%)+&).,+$*#%)$&((*)(,%&$$&((,',(,,**((((#)'($%##(,*,$+'(()#''*%#'#%%#$$')-&)-,-)+-+,)(&,-((,',-*),-%,+,)*)**((*+-+$&()*'(,*$(&'#$#$##(')(+)$*+,%+,(**&'&'''(%+&&)-)#"%*,-++.((,)&*')--((*%&),(*'%*+*(),*'((*(,)*-**')$(+,,-((&%,+,-,+$+*('%#(*----,,)).,,+())('(,-,((%+*(,)))+,-+&,((%(+,-&'(&%#%&)(,+('+%'-+**-,')((',*-+**-..+,+)+&#&#*'#'*,*-,--+-*),%(----,)-,'+.-*)'$((----),'---,)"&(,+,+,+.,&**+*'%*+---)&'+*%%*-))%%*'("$)+,&&#'+-,,)'%'('+(,-,,'$,(''*)*%()++#)&()&,),''&)*,.+-(%'#%'-),-(*(&+*-,+(,,&##))*($+-*,(%%%'%'%'$&-,),-+.(-,+*,*%(%*(),(,&)'')-+(*-*+%-,(+&,()+)'&)$(#&*)--)-+.,)()&)'',,+*-,$)#',+)*)'*)'*)))+$*%##'&'*(&#+,*-(+,+''&&$$%&&(#+*'%&)%'*$,&(),()(,(%#(-('$%#%**($#(('++)+),,-(-,**&+,&)$)$#!"$*&')(,((+),--)++,-,&%%&+,,-%(%*)+&-)*,,$+&+&$'()%'#('&%'&'%((')%%%#$%&%$()(&((#'((&#!%'%)((($%(%'$'(%(()())'#&'%&$%'("""#%%"%$''$()$$%$&('#%&($&&'(('#&&(##$%"#&($')$%&(&$'""#$$$%$$##&&%%%('$$##'%#"&$&('"$#'((#($$&$$$'&#$%(%&$&'(($%%%&$%(&'$$$$%)&()(('#''#&)()()(%%$&$)(')(%&"#()%&&'$(#')($&&&&#$$'#%%&'$&&$$''%%$&)("&%%(&(('####%$&)('(&&'#!"&#"&&#&&"$(()''(%&'$$#'())(###$%$&$$"""$"$#$$##$(&&&"&&&%"$#()()%($$'%##$%&'%'&&%(%&))(%(''(&%%(('$"%''((%#'#$('%%$$#"%%"%#$%%%$%&''(''$%$$$$%'()(%%'((&""%(#####$##'(""%$#&%%(()&%%')'(()(&$&&$&(%%&$(%((%(()$(($&((%$%)&))(&'#%#((%$(''$&$%)((%##&%%"&&(##"$$$$&($')&)((#&$#%''((###'&$"%('%('('%()(&*%%,-')**-*)$-,)+$,'($+(+&(,)-'&(()'%!##%'##$(&(*+*'(,)-$)&&'+((%'+/.)/+,&*#'*+/*,,&.0/+*%',&&##'-*&-.&)-'%*(/+.-/%.-/10../.-.,'#'&)*.'+&(-0/.1/+'/.*+*1/*//.0+-)+,&',.'&((.%$-)&(,+)+,-/1102.1021*011,1,)+()-/02011-1++,(),,10-.#&)*+'%,/10,'+)1,+)$1/,1./-++1//,)00-'*0.2,&*)).'&+%$%'##+-/.20'-'*+-1,&/+,)//)+,/.-%-&-$'(/..(11++/+$(*%,%%)+10.+&0/,(,-2-*/+.$&&)-/0*- @rCer/2503/0_1683_CCS TGGTGGAACTCAAGATGATATCATTGGGAGTGATTTGGCCTCTCCTCTCATATCATAGTTTATTCAGCACTTAATCCTGAGGGTCTGCCTGCCTAAGAAGGGCCTTCCCCCCCCTCAGCCGTTCCTCACCTCTCAGCCATATCTTTCGCCCCTTCCCTGGATCTGCGTGTGTGTGTCCGTGTGTGTGTCCCCTGTAATAGCCAGCTGTTATTTATACATATATAATATATATATTTGGTCTGTTTGTAGTTTTATTACTAGAAGATTTTTCTGGTTGTCCTTAACACCCTTCCTGAGGTTCCTTCACCTCCTCTCTCTTGCCTGCCTTCCCTTTCCCTTTCTTCCTGACTAGCCCAAGTCCTTCATTTGCATCTGCTATGCAATAGTCCCTCTCCTCTCCTTTCTTCCTCAGATTTAGCTGATCCTTCCCCCACCCTGGCCTTCCTTTCCTCCTCCCTCTCCGGTCATGCTCCCTCTGCCCCGCCTCAAAAAAGACCACAAAAAACAAAAGCATCTGTCCAGCTTCCTTAGGTGCATCTTGTTTGCATCCAATGGAGCTCTGAGACTGGCCCCACTTGTCCTAAGAATCCCAGGTCTTTGGGAGTGTCCAGCATGTTAAGTAGCGTATCATTACATACTGCCATCCCTTTCCATTTCTTTTTGTTCCATCACTCTTCTCTCAACTGGTGTTTCTTTTTTACTGAGGAGTTAGTCCCCATTAGTCCTTGTATCACATTTTCATTTGCACGACATACTTGCAGATGTGGGGAGCCTGGGCTTTTGGGGGACCAGGCTGCTCTGTCCTCCAGCATGCCTCTTCCTAGCTCTTCTAGTCCAGTTTGCCTCCCTACCCTCATTTCCAAACCTCTTGTACCCTCCCTCCCCAGCTGGTATGTAAGTGTCTTGGAGTTCAGTATGTTATGATGGACCAATAATTCTGCCACTTGGGGATTCTCCCACATTCCTGCTCCCCAGTTTTCATGTGGGCACTCAACTGACATTCCATGGGTTTCCCTCCCATCTGCCTGATCCACCTCCTCCTCCCACTAGGAGAGTTGGGGTTGCCACAATTGATCTCTTTTGGAGGGGTGGCTACCAGTGTGTGGGGGTCATCACTGCCTTGGGGAGGAGTGGGGCAGGGCAGAGAATCCCCCCAATTCCTGCCTGAAATCTCTGGCCTCACCCTGCTGGGGCAGGACTGAAACCCTCCTCCTCAATTTGGGGGGTGTTGCCCCATCACTTCCCAGCTCCTCTGACTTCCCCACCCCCGAATTTAGGGTGGGGTACTAGTCACTGCCAATGTGTGCATGGGACTTGCTGGAATATGGGGATGCTTGCCCCTCTCCAGGGCTATTGAGCCAGAGAGAGCTGTCTTTTCATGGTGAAGTGATTGAGGAAGGGTCTATTGTCTTTTTAAATGGCACAATTTTAAGGTCTGAGGTACAGTCCTTAACCTGCCACGGAGGGGGCCCCAACTTTCTTCCCCCACACTTGAGGTTTCTGTGTGGAGGGGAGCAGGATATCTAAGCTGTGGTGTGAAAGGGTAGGAGAGATGCTGGGGGCGGGGTGCTGTGTTCTAGACCCCCCATATATCCCAGTGTCCCTGCCCCCTCTTCCCCCACCCCATGCCCCAATTCTGTGGCGCATCCAGATTGTGAAAATGTACAATAAATGTGTAATGAG + S&'%%$#&#&'$&($(($%#%$"$('))',)+(,..)##"#$&'+)*&)'*)+,$0,3*/2.$65..-&-+-%/0(..6014$1./3%204*3.*01)4+65/-,(&.43+#%445/4)0)).%'&&*#(,)+/-(.,/2'-)%+'($$&(-(-)50+)4(*&#/41,10+12,1.,-('..0,/./)%0-1-/1+/,*146)331,,*.,3.(-',,.*/+1%-$)&&*$'/&*16;5:76&6491/6*772(+8,33-34750%21456:9;474--6*99:94(78,0,8.98.900'61746.648::::6684::4728-526.3:7;;*9959::/4&/-::74+(%37.66)&4144.',53*.6::::746:8.72*26)6./'-.463('/,*)3,+(1%(15.&71/2/581/+3-,%75580-570,7&43:08)/7)8:/9:)<=<95&6(-684<<97&89=9<=,:790*5*2(5768669)2,+)589:5((62.1432459456,$5(1%4/:6.86798366:9&4244<:.4/17'3$'+'0,267673-4%44+/,''$/'65,131:9,=*$048+:08=5::63;;:+<<=56386<%5835:<)974>*(568&4599:27/=:647,0969934681<8210<3(36,)9<8;:7;998780%.97960=?;48=4237?*;;865478:3==;9/2<;:6*3;:9-$8;5>05619;.+)2==9$*;23=?>->=:&84833,771<:'5128.5=2=775+6<.(1);;5*=6?=5:7*7&9;5206(<3:+=<99972:6,<9?6<:0$9;:>6?<4;63;?80(,5(+'$98*47473704<85/524;252=>):8>;;5;4/9>=+.);;1782*;7:84==47+/443+75/(;%9;;<27,5+==$9-2799%202$61038-79:799:7%<;4883<*='/8;>=2/%<<3$<:*:;,=>6(<98>>:99;:=6:121169(::.=5)867:;079?3/4738--8:==5847>8=6:8917.;>>>1;4+4%7;:8((<<;<:*;5=6):=:78<=/16>7=19397:95771*3+27710*7828;=&<;5653>8=)6)2:):=88<7;;3=+<'3;#86895675=6'437437;:.>&=;(795:?=;74>=(&&9;<4&/.5:9*85==857<0'3/&$&,75.748,.:,;9?487536>>=3<9>='<8:7:?7=063'68669>>-:;;??:>99:8:1:9:44%6;60$72:<5697<=884)'280.4$+<071?88=<2;<2-9)409<84=9379;6*:=;<4=>=8?<937=2>:>34(;57:;7%76:>493$:#1.50:1/0808$8$(376'#<84#77):9:36&9;9889<68><98;.<2711;:;867%::766:<+<297/-4/>048<94?;8::3=8&7;<=9:99:<727:6.=:::-&:83*24355;,;87:4(%9;940-1.*0/23?<4855(:1/,$:6==121;6>>:?71=;>18/%<;7'31:9084'2<5524158:=&;:38/79;24;:>32*&109=:>9-85038 @rCer/2505/25_1731_CCS ATGGGAAGCAGTGGTATCAATGCAGAGTACATGGCAGGGACAAGCCAACGCCAGGTAGCATGTGGCCACCTGCCCAGTGTCTGTGGCCTGGCAAGTGGCCACGCCCTGTGTCAGACCATCTGGGAATGAAGCTCCAGACAGACTTACAGATGCCTTCCTTAGGAGTTCTTGCTTCCTGCCTTGATACTTTGCCCCAGAAAGGCCTGGGGTTCATTCTGGTTCTTAATCAGGGTGTGTCACACTCTGCTCACAGGCGGATCCACAGCTTTCCAGTGCAGAGAGTCGAGATGCTCCCTGCAGCCCAGGCCCCGGGCACTTCCTGCAAACATCTCTGGGCTCAGCACCTGAGGCAGGTTTCCTGGGTCCCTCTCCAGCAAGCCTCCACCAGCAAGCTCGGCCCAGAGCTTCTCTTTCGGCGGCTCTGAACCGTGTGTGGTGTCTACAGCCTGCAGTCTGGAGACAAGCTTTTCCGGAGTGCTCTTGGAGCAGGCCAGGGTGTGAGGGGGTGCAGAGGCACCCGGGGCGGAGCAAGCCCCAGGTTGTGACAGGTGCAGGTAGACAACGCCCATAAGCAGAGATGGTCCTGAGCTCTGGAGAGATCCTTCCCTGATCCTTCGGACGACTACTTGGAGCCATAAGTAACCTCAGCAAAAACGAGCCTCTGCAAGCCACTTTTCCATGCCAAGCATCCACCTGGCCGGCCACAGGCATGTTTCTGCCACCCACTCCTCAAGATGGACAGGGAGCCAGCAGGCAGGCGGGAAGGGCCAAGTACAGGCAATCACCCCATCTTCTTGGTTGAAGCTTTATCCATGTATCATGTTCCTGTAGCCATTTTATTTTTAAGAAACTGCTAATACTTTCTCCCTAATGGAAGCCCTGACCCCCCAGAGAGCTACAGGTCTGCTCCGACGGGCCTCGGCCTGACCCGTCCACACAGGGCCGTGTCAGCGGCAGCGACTCAAGGACGTGTGTACATATGTAATGAGAAATAGAGACGTGTCAACAGATGCAATTCATTTCTCTTGGAATGTGTATTGTTTTTATTTTGCGAAACAAAACAACAACAAAAAAGCTTGGAACTCCATCACGTGGAAAAACTAGATCCTGTTGGTTATAGCATTTGTGAGTTCTCCACGTCTGTCTCTCTCGCTCATGTAATATACTCTGACCCTGCGTGGAAAGGGATTTTTGTTCTGTTTTTATTTTACCTACATGTACTATTTAGCTTCAGTGTACTAGTCCTGCACCTGTGTATTTTTAGGGTGCTATGGAATATGAAAAGAACGGGGATTTCAGAAGAAATTGTAACCAAATTCATACTTTGTATATTTTTGATATCATGATCACAGGTGATTCACACGTACACACATAACACACCCACCAGTGCAGCCTGAAGTAACTCCACAGAAACCATCATGTCTTTGTACATCGTATGTACAATGCAATCATTTCATACTTTAAACTGGTCAAAAAACTAATTGTGATTTCTAGTCTTGCAAAGCTGTATGTAGTTAGATGATGTGACAACCTCTAATATTTATCTATAAATATGTATTCAGATGAAACCTGTATATTAGGTGTTCATGTGGTTATTTGTATTTAAAGATCAAATTATTTGACTATTGCTAGACATTTCTATACTCTGTGTAACACTGAGTATCTCATTGCCCATGTTAATTTTTTCTAAATAAATTGACAAAAAT + 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@rCer/2507/2646_54_CCS TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGCCTTTTGCTTTAACAAGAAAGGCATTTAGTTTTCTTTTATTAAAATGCCCTCAATTTATTTGATGCCTTAGACATTTAAAAACATTAAGCTGTAGGAGCCTTGAAGGCCAGAACAAAGTTTTATCAGAGATGAATTATTATCACAACAGTTTTAAGTACACTTCTTTAAGAGGCAGAAGAACAACACCTGGCATTCTTACCAATTACTCCTCAAACTGAACATATACTTCAATAAATTCTTTCAATAATTTCACATTAGCAAGCTGGCAGACAGGACACGTTTTGTTGAAGAAATACTTCAAAGTGAAATGTTTCCACCCCGACCCCGAGTGATGGCATTCAATGTTAAGATAAATTTTGGTTTGCTAGATGAAAAGGCATTTGTATTTAAGAGAAATACTCCTCAATTTAACATTCCCAAGAAGGCTCTCAAATTGCAGTTCAAGAAACATAATCTAGAGTGCTTCTGAGTAAAACCAACAAAACCTATACATTATACATAAAAAATGCTACCTACTGTCAAAAATGTATTATATCAAGAATTTTATCAGCAGCATTTAAGAAATAAGAAATCATGGACAAGAGAAGACAAACATGGTAATGCATCAGACCAGCACACAATACACCATTTTCACACACACTGTCACCTGAATCCCTGGCAATTTCCTAGAGGTATTAACATCATACCTATTAAGAATTATTGGCCCCAAGGAAGGCGGGGTGGAAGGGTGCAATCTTTTTCAAATCACATCTGGCTCTACTTTCTTCCAGTTAGTATTACATTTGTATAATATTCTTATAGAAACAACTCAATTCCAATGTTATAAAGCACCAATACAGTATTTCATCCTGTACCAAAGGAAGTAGTTCTGAAAATTTACAAACAGGATTCGTGGGAAGGCACTTAAAGCTAAACTAGTCAAAAAAAAAGTCTAACAACAGTTAGACTTTTTTTTATACTGCAGGGTGCTTAATATTGTAATTCTTTGTTTATATCACTTAACATTTTGATCACAAATTTCCCAGTAAATTAAAAGCTATTCAAAACTAAAAAGGAAAGACAAGAAGGGACACAGCCCACACCCTGACTGATGGAATCAGGCCAGAGTAAATTTGCCTTCAAAGTAGGCAATGTTGTAACTTTAAGAAAGGTAAGATAATAGATGGAGCAACAGAGTGAAACAAGCATGGCCACAGTGGTACTGGACTCCAAGTATGGCTAGGGTCGGATTAGGACGGTTGACTTTAAGTGAAAAAAGAAAGTAAATTTCATTTTCAGACTCAAAAAGTCTTAAAGGTATCTTTGGATAAGTAAGCAAAGTAAATACTGTTCACCCTTGAACAGCATGAGTTTGAACTGTGTGGGTCTGCTTATACGCAAATTTTTAAAACCAAACATGGATGAAAAATACAGTATTCCCGGGATGCAACAGTACACACACGGGAGGGCTGACTTTTCATACAGGCAGGTTTCCAAAAGGGATGATGCAGGACTTGAGTATGCCGCAGATTGGGTATACACAAGGGTCCTGGTACAATCCCCTGCCTATACCAAGGATGCCTGTGCTTTCATATATATACTTTTTAAAACACATTTCATCTATACGCTTTAAGTGTTCCCTATTTTACCCAAATCTGAAGATGAATACCCAATATTACCATTAGTTCAGGTTACAAATGTAATATTTATAAGATTTGCTTATATGTTTTGGAATTTAACAAAAATGGATATATTCTTCAGTTCAGATGTACCTTTAGAGTCAATTAAATTATAAATTCAAAGGTCTACAAATGTAAATGCTTTCCTTATAATAAATTTGATATTTAAAACATCATTCACAATATAAATCCTAACACCACTGGTATGCTCAGTTCATACCTCAGTGATTCTAATACTTAAGAGGAGCATCTGTATTATCCTTTTCTATAAGACATTTAGGAAAACCGTCTCCCACCATTATGGGTGTTTAATAAGATTACTGTACAAAGTAATCTTATTAAGAAGGCAAGTAAACATTGGCAATCATTTTTTTCCCAGCTCATTAACTAAAAGCAAACAAAACACTTTAAAATGTCATTCCCCCTTAGGTAATCAATATGGAGAATCATTCTTTAAACAAATTCACCACTGAAAAATCAACCTTACCTTAAATCCTAATAGAAACACTCCCTTATTATGGAAAAATAATCTCCTTACTTCTCTCTACTCATACAATACAGAAACGTTACTGAAGTTGTGAACTGGTCTATGAATATGAACAAAGTTTTCCTATCACTGGGATACTGGATGGTTTGAAAAGGAATGCACAAACAGGCCTGCTGCTAGTACAAAGTGCCTTTTTACATGAATTAGGAAAGGATTCCCTTTCCTCAATCACTTTTTTACCACAGGCAGAAAATTGTGATAATTAGAATCTGCAATACTACCAATGTAAGATGGCTCTACTGAGCTGTGTACAATTACACCCAGAGTTCTCTCATGATTCCTTTATTCTATTGTCTTCTTTTCCTATGTGTATCTTAACTAAATCATATCAGAGCTAATGTCCCTCTTAAG 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@rCer/2508/1478_53_CCS CCGTACCATTACCGTGTGCCGTTGATGCAGATTGTTTGCTACATGAGGAGAACTTCTCGGTGAGGTGCCCTAAGCACAACCTCCCTTCCGTGCCCTCTCCCCCCTTGCAGACAAGACCGCGAAAGGCAGCCTCAGCACAGAGCAGTCGGAGCGGGGGTGAGGGGGCAGTGTGCTCGTGGGAATGGAAAGGACAGCAAGCACAGGTGAGACTGTGGAGATGAGAAGGTGGTGGACACTCGTGATGGAATGGAAATCGTCCTACCGTGCAGCCACACCCTGCCCGCCCGCCCGCTGCCTGCCATGCCAGCACTTCCTCCTAAGTCTCACATCACACTCAAACCGGTGACACCACGGAAGAAAGACCAAGACGTTGGAATGGCTGTTTCCATGGACACAATCTCATAGTGACAATGTGGGGAGGGGGAGGGTGGATGACGGGGAAAGGGTGGGGGAATTAAAGGGAGGGATAAAAAATATATATATATAATCTATTTTTAGTCTGGAAAGACTTTGTTTAAATGAAAGGTGCGCTATCCCTTTGATTCTATTTTAAATTATCTAGTTAAAGATCTCCAATTTGTTCTGATGACAAGTGAATTTAATGTGAAATTGAACTGAACAAACCCTCATCTCAAAAAGGACGGGTGTGTGGTGCTTTCATCTTTAGCCGTCTCACACAGTTCAGAAACACTAGACCCAGGATTGAAAAAGCAGGAAACCACACCAGAACCATCCTTTTGTCATATATTGTCTCAAAGTGGAAGGTTTTAGGGGAGGGGGAATATAGGACGTCCATGTTTTCAGGCAGGGGATGATGTTTAAACACAAAAATAATTTTTTTCATTTCCAGAAACACTATTTATTTTTTTTTAACTTTTGGGGTGAAATTGGCAGATGCCTGAGTCATAGCTGTGTCCTGGGTCACTGTGGCTGGTGAGACCCTAAGTGTACACAGCAGCAGCAAAACCGAGGGAGGACCCTCTGGGGCCCCTGTCTCAGCACATCCAGGCAGCTGTGCCTGACCACAGGTACCCGTGGGATGAGAGGAGGCCAGGCTGTGCTGCCAGAGCGCAGTGTGAGCTGTAGGCAGGATGGGAGGACTGTCGCTGTGATCAGAGTGGGTTAAGCTGACCAGGAACCCATTTAGCCCTTTTTCTTTTGCTTTCATTTTATAAGAAAGAGGACTGTCAGATAGCAGCCCCATGCTACGTGATCTTATGTTGTTTGTTTGTTTTGTTTTGTAAATTGTATAATTTTAATATCTGAGTTTTAAAAAGAAAAAGTACAAAAAATCTTGTTATGGCCTTAAGAAGGGTTAGTGCATCTTTCAGGGTCACTCGCATGGGATAAAATAGCTGTTTCACAAACAGTTTTATTTAAAAAACAAAAACAAAAAAATCAAAAAATC 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@rCer/2509/25_1975_CCS ATGGGGAGTCTGGGTTGGACTGGCGGCCGTGGAGTTTGTGACACACGAGGTGACACCCCTCGAGTCACTTCCCTTCCACTCCAGCTGGAGCGCCTGCCTGGCTTTGGGTTCGTTCTGCAGCCTTCGTCCCGCTCCTAGCCTCAGGGCCGGACTCCAGCGCAGAGCCCAGCCCAGCGCAGCCTGCCAGCAGCCGCCCAGCAGCCCAGCACGGCAGGAAACCCGGCCAGAGCTCCCCAGCAGCCGAGTCATGAACACCGAAATGTATCAGACCCCCATGGAGGTGGCGGTCTATCAGCTGCACAATTTCTCCATCTCCTTCTTCTCTTCCTGCTTGGAGGGGATGTGGTTTCCGTTAAGCTGGACAACAGTGCCTCCGGAGCCAGCGTGGTGGCCATAGACAACAAGATCGAACAGGCCATGGATCTGGTGAAGAATCATCTGATGTATGCTGTGAGAGAGGAGGTGGAGATCCTGAAGGAGCAGATCCGAGAGCTGGTGGAGAAGAACTCCCAGCTAGAGCGTGAGAACACCCTGTTGAAGACCCTGGCAAGCCCAGAGCAGCTGGAGAAGTTCCAGTCCTGTCTGAGCCCTGAAGAGCCAGCTCCCGAATCCCCACAAGTGCCCGAGGCTCCTGGTGGTTCTGCGGTGTAAGTGGCTCTGTCCTCAGGGTGGGCAGAGCCACTAAACTTGTTTTACCTAGTTCTTTCCAGTTTGTTTTTGGCTCCCCAAGCGTCATCTCACGAGGAGAACTTTACACCTAGCATAGCTGGTGCCAAGAGATGTCCTAAGGACATGGCCACCTGGGTCCACTCCAGTGACAGACCCCCTGACAAGAGCAGGTCTCTGGAGGCTGAGTTGCATGGGGCCTAGTAACACCAAGCCAGTGAGCCTCTAATGCTACTGCGCCCTGGGGGCTCCCAGGGCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTAGTTTGAGGTGTGACACCAAGTTTGCTCCAGAAAGTTTAAGGGGTCTGTTTCTCATTTCCATGGACATCTTCAGCAGCTTCACCTGACAATGACTGTTCCTATGAAGAAGCCACTTGTTTTAAGCAGAGACAACCTCTCTCTTCTCCCCTGCTTCATGAAGGCAGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTTCTATATAGCCATAAATGCGTATATATACCCATAGGGCTAGATCTGTATCTTAGTGTAGCGATGTATACATACACACATCCACCTACATGTTGAAGGGCCTAACCAGCCTTGGGAATATTGACTGGTCCCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTACCAAGTTGACCCAGTTTGTCCTTTAGGTTAAGTAAGACTCGAGAGTAAAGGCAAGGAGAGGGGCCAGGCTCTGAATGCGGCCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTCCACTGAAACGTGAAGTCCTCTTTTGAATGCCAAACCACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAACAGAAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGGGAATGGCTTTGATCCAATGGAGCCTGGGAGGTGTGCCCAGAAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTTCCACTTTTTGACACCTTATCCTGATGTATGGTTCCAGGATTTGGATTTTGATTTTTCAAATGTAGCTTGAAATTTCAATAAACTTTGCTCTGTTTTT + 66*>B@532:66B4>1@=27A8529A9>=;:0649512=9=<44/@<>688<:25;:6=5==,=7;6=5:?7;=06=8;;=.9;;9:65>90>:/9<9?><:<=36=-599:?9<86778;<8=6850>=<10<5*96>=9254/53:398*5.::24/8:89=<7<8759?;74976)<<9714%,75;9:87:0=<48177=3<8-==;97:0886>7275,59<737<83<4:8:67?':;;56?7=<92:'807=769;8&;27:4=->8.:><7.<<%038759:=AB?-:9>7B:B?9988<@9->918?7<>3>9=A;07;6@03B5:C7;>=<>?B8A3@<@@>CC=3;2257@A=08)8=@?=8.+,634-1,12<,3154.-(0<8@75#106*63.50/;:6<75>=3;9:34456485>51:82=@?=@=4?=9>=1:7?6,99936B26:>96A>9C5AB@5=48-55/249/7:>A7:4-9994&4232>?@646<5@9/@A=85=?5:6<<-A<:@@?)@86,<@@@9:=85@=?:A@===@;8.32719;CB2A94>7.A=><;,55;=73B<9;?289-23:41675.16A@;;50A084:29.?@<+?B?A+@>@1<89=872BA708399%6/28?8*32:3:=4A?2;<@=>>9BA@@6(<;98;98:A=><89<6B2:8:<:?85?B:5<;?:=8:4;*7:46@B<+A?BA;A.A?61=B7:@>@>=>;3=;::B6.9535775<.9=5590:;59/>:2;0>>5;B%737=><8<:;>:3>@:5;3292<<:+=;;+3;197868;>==<7?=@>9>==>5@?:667<=:@C@5678;9:;7=>->5=>/98<>>:A47<<<=?;)=9=5AAA8?:@?=>B8A=A;;>A=B>>;B>A:>7;CB=0>5>5@A4$673:5:;?;6,77;8;B<6A@.A9@7BC@C7?71;29=6>B?3AA8<9>A=B?6C?B&?<:86/:;64<8:;?56.0+4=4-==?;@1???;@B@?B8?;7;A9>8<56<:9A=--4444637;99ABBB<=8?95ABBAB905>;:96A>:@:7=56.,0<1;-73+3<<5?798=69;,;=5>?@C<@@9>234668:7693377119:9:).7<0:80+1250+4:<2;=<<7=>>>6=0:6/.1)5.6961;680562::6<2,<97;:2=8:<==+:>;&459841&2477<53//38=2+/.&,1=/6989::6<=-96::9:8)737766786.096<:478::88>2>7<<&09<9818=:6967><<9=5985:=;5:+442897-43233-,55146344:83=:87?703-05<25:<9?>23988;0=<7<>:+9<9**7764&498:26>;;0:?;:*:73,7==6.9;4$7.6<3;365/379803161)398;+2788<9=>;-7839:.:754%62292983--5188:>2:87;67047-<9;.7588;3?:2-08;58+7;:5<86:47&4348=:712,55&07454/329:==>:+<55:;9=6/:.52./+,<:7.-0/4<3;=>74442;:/99-71575)4189869:58/994676282&554757'076118985545,9988 @rCer/2510/25_1302_CCS ATGGGGCAGAGGGGCCAGCCCGCTGACAGATTCTCGGTGGCGGCGGCAGCGGCGGCGGCCCTGGACTGCGGGGAATGGGAATCCTAGGTCCCTGACTGAGCACCTCCCCCGCCTCCCTGCCCCCGACATGGCTCAGGAGAAGATGGAGCTAGACCTGGAGCTGCCTCCGGGTACGGGCGGGAGCCCGGCGGAGGGCGGCGGCAGCGGCGGCGGCGGGGGCCTCAGGAGGTCTAACAGCGCCCCCTGATCCACGGCCTCAGTGACACTTCGCCGGTGTTCCAGGCCGAGGCGCCGAGCGCCAGGCGGAACAGCACAACGTTCCCGAGCCGCCACGGCCTGCTGCTACCGGCCTCCCCTGTCCGCATGCACAGCAGCCGCTTGCACCAGATCAAACAAGAAGAGGGTATGGACTTGATCAACCGAGAGACGGTCCACGAACGGGAGGTGCAGACCGCAATGCAGATAAGCCACTCCTGGGAGGAAAGTTTCAGCCTGAGTGACAACGACGTGGAGAAAATCCGCCTCCCCCAAGCGCATCGATTTCATTCCTGTGTCACCGGCACCGTCACCCACTCGGGGAATTGGGAAGCAGTGTTTTTCGCCATCCTTGCAAAGTTTTGTAAGTAGCAACGGATTGCCTCCAAGCCCTATTCCCAGCCCAACGACCCGATTTACCACACGGAGGAGCCAGAGCCCCATCAATTGCATTAGACCAAGTGTTCTTGGACCATTGAAAAGAAAATGTGAAATGGAAACTGATTATCAGCCAAAGAGATTTTTCCAGGGCATCACCAACATGCTTTCTTCTGACGTTGCACAGCTGTCAGATCCTGGTGTGTGTGTATCTTCGGATACCCTTGATGGAAACAGCAGCAGTGCCGGATCTTCTTGTAACTCACCAGCGAAAGTCAGCACTACCACCGACTCTCCTGTGTCACCTGCCCAAGCGGCTTCTCCATTTATTCCACTAGATGAACTTTCGTCTAAGTGATTCACTCATCCTGAGACTTTCTTTTTGCAGTGGAGAGAGAGAATAATCAAGTTGGGGCAAACACTGAACTTTGTCAATTAATTTGAGGCTATTTCCTATTCGACCCCTTTTCTTTTTGAAATTTCCTGAAATGATGTTATTCTAGAGAACTTCTATGTCAGGTTCCTGCGGATACCTTTGAATTCAGTGTAGTAATATTTTCAGACGTTTCCCCAATAAGTGTGTTGAAGCATACATCTTTACGCTGCTACTATGTCTAAATACATATGTTATCCCTTGATTTTTT + KI$KKJJFKJ7KKKKKKKIKKHKKJKKKKKJKKKK&HHJKGDKK6KJKKJKKKIJK;K?KKJKKJJKKI,HK36KKDKK=KAAJKK7KKCKKKKJKJHFHDKJKF)KKKKKGKJGKKJJ:KGKKIFJKKCKKJJICKFD:KJIJCKJKKJJJK:KHKKIKKJKGKJHKKKK>EIHKKIEKKKK>KKKKKAK9CFGKGJK>KKEIKHKKJKKCKF(IJJI@KKKGFDBAGDJK>GIKIIK&HKKJJDEKFKGKEKIKJKKKKHKJKJJJJKDKHIGKHKJKJDJFKKHJKKJHKKKKKKGKKKKJBKAKKIKJAKJKJKEK;KK>BHGKKDJIKFKAK=HKGKJ8H?K4HKKKCKKJJCJKKKK@>HKKKKKDJJ2HI>IKF,HHKHKHJJ;JGK=KJDKKK-KE@II8KKJ>JJH2DDJ6KJGAJKJDKKJKKEHJHKKDKKKIKKIHGKFJKKKAJ;CKHJIJ?KJHKAJK2KK=KIK>K=KKKIKKKJKKKJKKKHJHHGKKKKKJK;KH>$KKJIJKKGKI:KKKKFKGKI>;JIKKHKKICCKKKKIJKKKKDKHKKFJKIIKIFKKICJI*KHC;J@KDKB1FGKKIJJ7KKKKKKKKGIHKFKIK@KKI>JKKHD@KKIKKKGKKJKKKKKGJFJKAKK?KKKKJKEJKKKJKKEKKKGGBKJB;KAJKKAJIKKKJ:KIJJKKKFJ0KFKBHKEKEJHJKFKHKK:CF=406AHJKIJJKCGKKGDKIKKGIKJKIIAHFKKFKGFGEKKBKIF(0D/HKHJIJIKJAIFFDJEGHJH?JIDKJK:KKJKEHGAKHK;KKDHJJHKIJDJ@J@AIFJIIGFBEBAHD4?H?FAHBKGAKJK8KKGKKIJJJCKKJIK.KIK:CJBEKJKK?KKCKKKIKKKJJJ8K:DJIHJJGKGKIKJIDJJJ3JKKKIKJKIIJHJIJFKKICFJIKKIAKJDK@KKIJ)JJJGJJIFKKAKKKJKJKFECKGKKJEJKKKI8KBGKKKBIJI71IJAAKKKK%KKKKK=KK;KK>JKHDKIEHF?I@KF=KJHIJCJ7KJ8KGJJKKKJK8D?KKKKIKFKJKIBJ6KKKKK?KKKKIFJHKKJKJE8JKKKEJHKJ?KKIKKJGKKKKJ?C?K@KJFKKJDHIKKKK;KKHJJJKKJJKKKKFDGJGHAEI:KGJ9KKKJH @rCer/2513/0_1516_CCS CTGGGGGAGAGGATATTTCCTTCACACCTTCTTCAGTGACGGGCGCTGGGCAAGCTGAGGTGCCCCGGCCGTGTTTGTGACTTGGAACCCCGCGGTCATGTGGATGAGTTCGCACAGACTGGGCACACGTACCGCCCAAGGCTCTTCCGCCGCCTGAGCAAGCTCATACAGACAAGGGATAGATGCTGCCAATACTGATGGACCCGAGGCACTACACCATTGGGCAAGGAGGATCATTGACCTTGTGTTGGAGCCGAATAGTCGTAAGCTGGCTGATCCCAGTGCCCGGTACTTCATGGGCCTTTCTTGGCTTGGTTCTGCACACGCTCTTGGTGGGGGAGAATCTTGGTTCTGGGTTCACCTCCTGCTTCATGGGAACGTTCTATTCTCCAGGTTGATTAATGGCAAGAAGTCCAGAGCTGGAGTTCTCCATTTAACCAGCGCCCAGGTTTCCACAGCTGTTAGTTGAGCCCTACAACTCGCAATCTCACGACACCAACCACCCTGGAGCCTCTGAATTGTGCCTTCCATCGGTAGACAATGGGCGATCTATGACATCTGTCGTAGAAACCTTGATTATGAGCGTCCAACCTAATTACTAACCTGATAGTCAGGTTAATAGGTCAAATTGTGTCCTCCATCACGTGCATTCCCTGAGATGATGGAGCCTGAATGTTGACCTGACGAATTCCCAGACCAACCTGGTGCCCTACCCCCGCATCCCTTCCCCCTGGCATCATCAGCCCCTGTCAATCTCTGCTGAGAAAGCCTTACCATCGAACAAGCTTCCTGTAGCAGAGATCACATTGCTTACGTTGTGAGCCAGCCACCAGATGGTGGAAATGTGACCTCGCCATGGCTAAAGTTACATGGCTTGCTGCTCTGTTTTACCGTGGTGATGTGTTCCCAAAGATGTCAATGCTGCATTGCCACCATCAGACCCAAGCGTCATCCTAGTTTGTGGATTGGTGCCCCACTGGCTTCAAAGGTTGGGCATGCAACTACAGCTCCCACTGTGGTGCTGGTGAGACCTTGGCCAAGGTTTCATAGAGCTGTGTGCATGCTGAGCAATCACACAGCATCTTGCTGAGGCCTGGGCTCGCTGGACCACAAGTTGACCTGAATGTATGCCAAAAGCGTGCTTTGTTCAGCTGGTAAATGTGGGTGAGGGGATGGGATGAAAAAAGGAAAGAAGGAAGGAAGGCGAGTTTTCAGAGGCCCGTGAACGACAATGCTGCCCTTGAAAAGAAGGTTATAGGAAAGTGTGGCAGCTGTGAAATGGATGAGAGATGAGAGAAGGAGAGAAGTACGTAAATTAAAATGTCACAAGGTGCTAGCTTTCTATATGTATATGTTAACGTTGAGAAGTTTGTCGTGCTGCGAGTTAATTTGTATGTAGGCGTGGTATGCTGCTGTATGAATAGCACTGACCTATGCTTCCTATTAACATGAATGCTGTTTTACAGACCCACAAGCGCAGTACTGGTGATGGGTTTGATGAAAGTATTCCCTGTCT + '$&&&$'*,$('(#%'&')')'')%+%)"$%(&$+&'-$%%(&+*)'%')+$---'"$)#,"&%''&"%++,)*+(+&$%++,-((+')-#%)*,./-//&$**-,($*#$+-)&#"#$&#%(*#+'$"%+)-'$(-#,.$,*,*($,##'"$-.----$-/...-/.-&,(-(.&#)(#+(((,'+(')#+%#+(#,,%'&(+'+%((-')$%*+')')&'((.&.-,.'-*&/'--(+*%$*&(.-,-,.*)-%).,$"//./,).'(.+/(.."%'-+.)&&$,*,($,),$-"#-**.-*-*&,-*&&-%'(-+$'--'.$-)-$+''('$%$&)**+(&-+)(*(',)))-+/%-*.(((-+,*''+*#&%'%+#$$)%%#+-)(...(-*.-,'%*.,*-%%'%'%(%#)"&)(-))*.+-,-%-()*.)**,%)(,&*(+(&+%,%&)--)/#-&&).+....%*)-&**/./.&/$..('+..&%,)*&)',#-*$($'+.*)*/./-)/$-,-(,(,**..-&.//.//.*-,((+/%//'/../,,+.////'/../,*/*/)..,%(././....*-),.(.%-$/...*-+,+.-#.(/-..).%*/...)./,*+....%.(,.+/).&./.../',/('-//,&.&-..,)+*,*-.&*(.)----(.,-)'',,-$)(.*.,((.(..../))%..-&%$(-'../$,&-.'(('..,+*.)&(-&+-&,'(...#$/$.....+.'$/,*-/).#.*.&.-#-,'.$,&(###,%-.',*/.*./*/().%',%')&.#-+/.,..,/-&&.%'.*/-/.(*,-"(./'-.&*'(/.,/.+-,"-'&)"'$*-...,*-.-+&.+#.//.+.&.&/-.,-../.$/'+-#'-,-&....)*'/'../-/)..++(.-.///./-*-")-....-'/-(%..-+-/.,*+)(+-..((+.///-+/,//('.&--&%&)/)/#,&/-.-)-%*'+)////-.-..-+&,--,&(-*'+%-+%*%'-,.&/)/$....*./.,--./-.+/-..+()$++'&+-.&).)--*,//..*)/.#-+)./-(/(..-//.%./(*/.)/,/$-,-/+(-*.)&$&./../.-)*.,...#./-.($&.///,&//./,%)--((*-++.,,+,(--*+(..%+#,&+)-)./,')).&$),.,.&-(#,.'..'.,//-)//')+-')..-)$((//*+.,-/'+/.,%#-,.-+&'-&./.()*,*'+-,,'*)#+*(,%+*'%$*"%,*,,'*$,%*($($&$)"&#,)-,,+,&#)(+*+)+,-%&*"&)****(%($($%*(.,,%&+,$).-,,&',-$--,.--+-/--+('%.)&+/.-.-$//---/-)/(+%/////(.'/..(/+//--(#--*.$"/'/-/./*.//+/)/.+,..'*+#..//-*%,',#+/.,,---(,/.)--.++'+&%**..+,*//.-,.(+/&//.. @rCer/2514/1713_54_CCS ATGGGGAGGAAGCCGGCAGCCAGGAGCGGCAGCGGCAGCAGCGTCCGGAGCAGCCGCAGCCTTCTGGAAGCTCCAGGCGGTCTTTCTGCCGAGCCTCGGTCCGGCCCCCATCCTCCCCGCCCCATCGGTTGTTGTCTGGGCGGATTTAAACAGTCAAGTAAAATCAAGCTGGGTAATCATGGCAGAAGGTGGATTCGATCCCTGTGAATGTGTTTGCTCTCATGAACATGCAATGAGAAGACTGATCAATCTGTTACGGCAGTCCCAGTCTTACTGCACAGACACAGAGTGTCTTCAGGAATTACCAGGACCCTCTGGTGATAATGGCATCAGTGTTACTATGATCTTAGTGGCCTGGATGGTTATTGCATTGATCTTGTTCTTACTGAGACCTCCGAATCTAAGAGGATCCAACCTACCTGGAAAGCCAACCAGTCCTCATAATGGACAAGATCCACCAGCTCCTCCTGTGGACTAACTTTGTGATATGGGAAGTGAAAATAGTTAACACCTTGCACGACCAAACGAACGAAGATGACCAGAGTACTCTTAACCCCATTAGAACTGTTTTTCCTTTTGTATCTGCAATATGGGATGGTATTGTTTTCATGAGCTTCTAGAAATTTCACTTGCAAGTTTATTTTTGCTTCCTGTGTTACTGCCATTCCTATTTACAGTATATTTGAGTGAATGATTATATTTTAAAAAGTTACATGGGGCTTTTTTGGTTGTCCTAAACTTACAAACATTCCACTCATTCTGTTGTAACTGTGATTATAATGTTTGTGATAATTTCTGGCCTGATTGAAGGAAATTTGAGAGGTCTGCATTTATATATTTTAAATAGATTTGATAGCTTTTTAAATTGCTTTTTTCTGAGGTATTTATAAAGTTATTTGAGGTTGTCTGGGATTGTATGAAAGAAAATTAGAACCACGTTGTATTACATTTACCTTGGTAGTTAATTTGTGGATGGCAGTTTTCTGTAGTTTTGGGGACTGTGGTAGCTCTTGGATGTTTTGCAATTACAGCTGAAATCTGTGTCATGGATTAAACTGGCTTATGTGGCTAGAATAGGAAGAGAAAAAAATGAAATGGTTGTTTACTAATTTTATACTCTCATTAAAAAATCTCTATGTTAAGAAAACCTTAAATAAACATGATTGATCAATATGGCAGATGATTTACAGTCCATTATATAACATTTGTAAGCCACTCAACACTAGCCTTACAAGGTTCATGAAAGGAGGAAAACATTAATTCTTTCTGCCTTTGCTGGTATAATCCACATAATAATTTAAGCTATAATTTATTTTTAAATGAGTGCCTCTTGGGAAGTTTCTTTTCTGTCTAACACTGCCTGTTAAAATGAAAATCTTAGGCTGGTGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCATTTGAGGTCAGGAGTTGAGACCAGCTTGGCCAACATGGTGAAACCCTGTCTCTACTAAATATACAGAAAAATTAGCCAGGCGTGGTGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCCAAGGCAGGAGAATTGCTTGAACCCAGGAGGTAAAGGTTGCAGTGAGCTGAGATCGCACCACTGCATTGCAGCCTGAGTGACAGAGCAAGACTCTCTC + .0338,97/<0>745273;:62?:<:54-547770=9::9;<>7?68,/54<;>794:?>;609;<=1;*-5:%01<<.:9?8/8:1-)168'8,'3/..65&489/:3.4%=<@>*.:586>?A99-84/1?,70*441-?=764=/36.5,3>@/:;<4;=<7=.7:.4=@9<693:55CA@4/8?>><;969/3539;86?<665.861@?;5674042125))::8894<<018;.>;9=:>9=,33'%5:=19<506:75*89<:3.+(677881<;-9/-42-0>67,.7,09./92>>2136375<3(8@=9803.76359;;29:2-16;75B048<43=,8A->C89,5FB9@507D3@;C;A9FA<2:8?6<6<:8:A9@913:48<7?,EA3<;55;8<>>7;A986:%><385?;:83A7;=554+8B2@<6@CA??=.F962.<>>6B39<=:439>5>:898A=<@;?>3?04)@6@0@C;CAC7=??B@A,3?E88/46=&:B/59=*:6<7@@:+>:;;8,DA5@;::0:5>:?::289>09B0,D9AE4<3B;7A5?F=;16:98D0B>;IHG9F@?>6E9:FGD$(==:'?A;D;;;=CD7?DAAD=87'89A6;;GAC?DF:=A@3%=E7<1>;943<9>1@=EA6@5CC8E6D@ICE?B03+820>6@464+1<;43:+@:@>>7@==@-AF:<-745A=78%$5<;B566==.+/;D*D@->6C/?=F6=+A7@A?B;BH7AA829@G>@<837;,>ED5?56A>G@:=;H1;9::7+89(H3G7@9.@2D/F@>>>B<$=;>90:CEE3AGG4DC37EDAA>A>@953?=?(7EHG.@:=$.09>:BB2A>83><9=;@CE:=D=G9<C??@85669*2FDH-/BAD@->5AD>E@>?683?B6//<@?:9>F;B;<:8>9%>99;=%4@DA@*6<@>6B59?E0;3:?9>>E;@GFB9<388?=;;7<77=*8>?=1816;>=@@@B3@=><4;?::>D?A:A;J;A@3=9BF7?39>C9=(C/6@;;AE8G@A?:;:?*=BCE81:,>>?2<9D=2AA/BBF?A6*.3-398;:5=?382*=B,@,B@;5=:6@=6:BGHC1=@&-(1*-7:(27G7DH)D@BFC/=>,;<9GE,@@D2=?;B8>/6<68.:C178?%EG1?D:EAC9JCHJI7BI5CCA>CB)@;F;@?8>:?:@(7=GGH8-?A>):-@:C:A>5G57?882@@@EE=@1D:=5>9>@+:/=B334935%25<-4951%7A<::>>8+;?474,25+=4B:;>>=??<8+0,61342 @rCer/2517/0_1745_CCS GCTTTCAAGAGTCCACAGCCTGAGAGGTGTCCCAGAGAAAGGGGACATAAGGGACAGCATGCTCAAGAGCAGAGGTGTTAGGGCAGTTTGGATTAGTGAGCAGCTGGTTTGCTTACAGAAGATTTTAGTGGCAACAGAGGACAAAGAGGAGAGAAAAGGAACTCACATTTATTGAGGGCCTACTGTGTGCAAGGTGTTTCATGTATATCTCACTGAATGTATACAGCCACCTGTTGTGGTATAATTTTGCTCTTTATAAGAGAAGAAACTGAAGCTCAGATGGGTTAAGTGGTCTCCTCAACACCAAATGCTAAGAAGTAATGGAGCCTAGACAGAACCAGAATTTGACTCACACTAGTCACCCTCACCATCTTGATGACTTTCACATTGTGCTCTGCAGTTCTGCAGAGATTTCCAGTAGTTCATCTCCAAAATGTATTTAAACTCTTATTTTTTTTTAATTGTTATTATTATTATTGAGACTGAGTCTTGCTCTATCGCCCAGGCTGGAGTACAGTGGCACAATCTCAGCTCACTGAAACCTCTGCCTCCAGGTTCAAGTGATTCTCATGCTCAGCCTCCAAGTAGCTGGATTACAGCGCCCACCACCATGCCCGACTAATTTTTGTATTTTTAGTAGAAACGGGGTTTCGCCATGTTGCCAGCTGGTCTCAAACTCCTGACCTCAAGTGATCCGCTCACCTCAGCCTCCCAAAGTGCTGGATTACAGTGTGAGCCACCACGCCGGCCTAAACTCTTTAAATCTCTAGTAAATAACAGCTAGATTCAAATGGGCTGATAACCAAATTTAACACAGAAGCATTCACCACAGGTTTGCGTTTATTCCAGATGGGCTCATTTGTGTAGACCTTAGAGCAAAGTTTCCTTTATGGTGTCTGTGTACGTATCTGAACTTTTAATTGTTCATAGATTTTAAAAGCGGTAGTACCACATGGCTGTTTAGATCAGACCTGTGTATTTAGGTCAGACCTGTGTATCACATAAGGTGTGAGTGCAGTGCAGATGAGCACATTTAGTTATATGTGCTAGGCAAAGCTCCAACACAGTTGATGTGTAGTCTCGTGGTAGATTTGTGCTACTGTAAGCAAATTGCTTAGCTTCTCTAGACATCAGTTTCCACATCTGAAAATAAGAAGATGAGAGTACACAGTTGTTATGAACAAATGACTTAATGCTTTTAAGCACGTTGCATGACATCTGGAACACGGAAAGCCCTCAATACATTGAAGCGCTTAGGATTTTCATGATGTTGCTGTCTGCTCATTCAATGCATGCTTTCTTTATTGTCCTGACAGTTGTGCGGTCACAAGTTATATGCTTCCAGTTGACTTCCAGTCTACCGTGGTGTTAGAAACCGTTTCAGCTCTTATTGTAAATTGAGTGCTTGTTGTTTTTTATTTGTGATGACTCTTCCAGCAGTTGTTGACAATTGTGAGAGGTTTGACTTTTAATAATTACTTATTTTTCTGATTGTGGTTCAGTTTAACTGAGAATATCCTGAGATTGTAAGAAAGCATTTTTTAAAGGTATACTGTGATCATTTATCTTTCTAAATTATATTTTAATACTGTTCGACCAAAGTGATGCGGTGTTACCATGACTCCCTAATTCATGTGTTTTTGTATTTATGAAATGGTTTCATTGTCATTTATTGACAGTATACAAAGTAAATGTTATAAATGTGAAGTTATAAAATAATGTGTGCTAATAAATCCTAAGTTTTT + 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@rCer/2519/2176_61_CCS ATGGGGCTGCGCTTCGTAGACGCCGCGTGTCCCGGGTTGTAGTCAGGCGTCGTCAGGAGATTTTGGACTCTCTGCAGACTGTCCCTGGATCGTGGGTTAAAAATCTGTATTCTGGTCTGAACCGTGGGAAGAAAAAAATAGTCGATCTGGTTTTTCTGCTTGAAGGACACAATGTTTCCAAACTAGCACATTTGCAGAGGTTTGCTGTACTTAGTCGCGGAAGTTCATTCTTCAGTGGCTTCTGCTACATCTGTTGCAACTAAAAAAAACAGTCCAAGGCCCTCCAACCTCTGAAGACATTTTTTGAAAGGGAATATAAGTATGGTGCGCACAACTACCATCCTTTACCTGTAGCCGTGGAGAGAGGAAAAGGTATTTACTTATGGGATGTAGAAGGCAGAAAATATTTTGACTTCCTGAGTTCTTACAGTGCTGTCAGCCAAGGGCATTGTCACCCAAGATTGTGAATGCTCTGAAGAGTCAAGTGGACAAATTGACCTTAACATCTAGAGCTTTCTATAATAACGTACTTGGTGAATATGAGGAGTATATTACTAAACTTTTCAACTACCAGAAAGTTCTTCCTATGAATACAGGAGTGGAGGCTGGAGAGACTGCCTGTAAACTGGCTCGTAGGTGGGGCCTATACCGTGAAGGGCATTCAGAAATACAAAGCAAAGATTGTTTTTTGCAGATGGAAACTTTTGGGGTAGACGTTGTCTGCTATCTCCAGTTCCACAGACGCGACCAGTTACGATGGTTTTGGACCATTTATGCCGGGATTCGACATCATTCCCTATAATGATCTGCCTGCACTGGAGCGTGCTCTTCAGGATCCAAATGTGGCCGCGTTCATGTAGAACCAATTCAGGGTGAAGCAGGCGTTGTTGTTCCGGATCCAGGTTACCTAATGGGAGTGCGAGAGCTCTGCACCAGGCACCAGGTTCTGTTTATTGCTGATGAAATACAGACAGGATTTGGCCAGAACTGGTAGATGGCTGGCTGTTGATTATGAAAATGTAGACCTGATATAGTCCTCCTTGGAAAGGCCCTTTCTGGAGGCTTATACCCTGTGTCGGCAGTGCTATGTGATGATGACATAATGCTGACCATTAAAAACCAGGGAGCATGGATCTAACATACGGTGGCAATCCACTAGGCTGCCGAGTGGCATCGCAGCCCTTGAGGTTTTAAAAGAAGAAAATCTTGCTGAAAATGCAGAAAAATTGGGCATTATCTTGAGAAATGAACTCATGAAACTACCTTCTGATGTTGTAACTGCCGTAAGAGGAAAAGGATTGTTAAACGCTATTGTTATTAAAGAAACCAAAGATTGTGATGCTTGGAAGGTGTGTCTACGACTTCGAGATAATGGACTTCTGGCCAAGCCAACCCATGGTGACATTATCAGGTTTGCGCCTCCGCTGGTGATCAAGGAGGATGAGCTTCGAGAGTCCATTGAAATTAATTAACAAGTCCATCTTGTCTTTCTGAGGGTAGCCAGCTGTTTTCAGAGCGAGCTGGAGACAGGTGGTCCTGTAAAAGCTTTGTCCTTAATGCGGGCACATTCCACTCCCGTGAGTCTTCAAAACTTTTTTTTTGGAATATATGTTTTTTTCAGTTGATACATAATAGAACAACGTTTCTGACCCTGCCATTTGCTTGTAATGTAACTAAGAGAATGTAATGGCATATATATTCAGTGAAAGTGTTTTGATGTGCATGTGTACTTTCTAAGTGAAATGCATCTATATACAAACAGCCTCTAAATCAAGTTCTTCAGTATAATTTATATATGTTTTTATAATTTCCTCACTAGTATAAGTGTTTCATATTTGAAAAAGTTATCTCTGGGGTATTACATAAAAGGCTTCACCTTATAAAATGAAATCATTTTTACTGAATTTTAGGAAGGATTAATGGTTAAATGTATGTAAAATACTAACATTAAGTAAACTTCATATTGGCCAACACCAGGGTTGTATTCTATGGATGTCATTATTTTGAATGAAGAATTATGTTTAACATTCCTAAATTGTTTGAGTGCTTGATTATAATTTGTAAAAAATGTTTATTTTCAATATTTCTTTAAATTTAAAATAAAGCTTATATTTC 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@rCer/2523/25_2257_CCS ATGGGGCTCTGGCGGCTGTCGCGACGGGGGTTCAGGGACCATTTATTGGGGCTCCCCGCTCCTTCTTCTTGGAGTGCCATGAGATCGGTTAGCTACGTGCAGCGCGTGGCGCTGAGTTCAGCGGGAGCCTCTTCCCGCACGCTATCTGCCTTGGAGACGTTGATAACGATACGTAAATGAACTGGTGGTGGGAGACACCAGCGGGAAGGTGTCTGTGTATAAAAATGATGACAGTCGGCCATGGCTCACCTGTTCCTGCCAGGGAATGCTGACTTGCGTTGGGGTTGGAGATGTATGTAATAAGGAAAGAACCTGTTGTGGCAGTGAGTGCTGAAGGCTGGTTTCATTTGTTTGACCTGACACCTGCCAAGATGTTGGACGCTTCTGGGCACCACGAGACACTAATGGGAGAGGAGCAGCGTCCAGTCTTCAAGCAGCACATCCCAGCCAACACCAAGGTCATGCTGATCAGTGACATCGATGGAGATGGGTGTTGTGAGCTGGTGGTGGCTACACAGACCGTGTGGTGCGAGCTTTCCGCTGGGAGGAGCTGGTGAGGGTCCCGAACATCTCACAGGGCAGCTGGTGTCCTCAAGAAAATGGATGCTGGAGGGTCAGTGGACAGCCTCTCAGTGACTCTGGGACCACTGGGTGTTCCTGAACTCATGGTGTCTCAGCCAGGCTGTGCTTATGCAATTCTACTGTGTACCTGGAAAAAGGACACTGGGTCCCTCCTGCCTCCGAAGGGCCCACGGATGGCAGTAGGGAGACCCCAGCTACCCGAGATGTGTGCTGCACCAGACATCTGGCCGTATCCACAACAAGAATGTCTCCACTCACCTAATTGGCAACATCAAACAAGGCACGGCACTGAGAGTAGTGCTCTGGCCTCTTTCCCTGTGACCCTGGATGGGACACTGAAGCTCATGGAAGAAATGGAAGAAGCAGACAAGCTGCTGTGGTCAGTGCAGGTGGATCACCAGCTCTTTGCCCTGGAGAAACTGGATGTCACCGGCAATGGGCATGAGGAGGTAGTTGCATGCGCCTGGGATGGACAGACATACATCATTGACCACAACCGCACCGTTGTCCGCTTCCAAGTGGATGAGAACATCCGTGCCTTCTGTGCAGGCCTGTATGCCTGCAAAGAGGGCCGTAACAGCCCCTGCCTCGTATATGTCACTTTCAACCAGAAATCTATGTGTACTGGGAGTGCAGCTGAGCGATGGAGTCTACCAATCTGCTGAAACTGCTGGAAAGCAAGCCGAGTACCACAGCCTGCTGCAGAGCTGGGTGTGGATCCTGACGACCTCCCTGTGACTCGTGCCCTGCTTCACCAAAACGCTCTAACCATCCAGACCACCACCACAGTGTGCTTCCTCAAGCCTCCAGGATCCACCTAGCCGTACTTGCCTCAGAGCTGGTGAAGATTCTTCCGAACCCCCTACCCCCTAAAGGTATCTGTGATATTGGCAGGATAGGAATATGCATACAGAAATGCAGGATTTGACTCGGACATAAAGATGGCACAGCGCTAGGGTGACCATGAACTATAGACCTTGCAGTCTTTTGTGAAAGAAGAGACAAGTTGACCTCTGCCCATTTCCTTGTGGACTCATCCATCACGCCAGCAGGGTCCTAGGACCGGCCTTGTTCCAATCATCTGGGACATGTCCCACTTCTCACTTTGACTGTGTTGAAAACAGGACTTGTTTGCGTGGCCCCAACACCCATAAGGAACCAGGCTTTAGGCCAGGGGGCAGTGGAGGTAAAGGCTCCACCCCATCTTAAGCCTGTCTTCCATGGCATAATTCCAAGTTCTTGACGTTGGTATTGTTAAAGAATGCAAACTGTTTTTGTTTTGAGGGATCTTTCTACAGTCTGGTCTCACCATTTCCTAGCAACCCTGAGATGATTTTCCCCATTTACCAAAGCAGCTGGGTCAGTGCTTTCTCGTGTTGCCATATTCTTCAGGTATTAGTGAGCTTCAGAAGCCCTGCTCCCATTTTTCACCCACCATTCCCCATAAAAAAGCTTATTGTCTCTAAGACAATAGTCATTTAAAATGTGATGCGGTTTATATCCAGACCACAATCAGAATTATATCTTGGTCATTTATGTGCCGCTGTTCTGATTCTCAGTGCTCTAAGTCGTGTTTTTCAACTGTGGTTGCAGTCCTTTGGTGGATTATGGCCAGCATTTTAGAATAGGTAGAATAGAATAAAGTAAAAT 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@rCer/2524/1087_73_CCS CCCTCCTGCCAGATGGCACCGCACAAATGCTCGGGATGCCTTTCTATGACTAAGCGAGGCAGGCGATCAGTCAGTTTGTAGCTGGGCGCCTTCGCTGGGTGATGAGGCTCAGTCAGCTGTCTGTACACGCCTGGTCCTGGCATGGACCCTGAACCTGGCTTCATTGGCGATGAGAGGCAACGATGAAGAAGGGCGAAAGTCCCTGTCACCTGAAATTGGAGACTGCCTCAAGTCTAGGCAGGTCCCCCCACTCGCCCCCACAGTGTGGTGCTGTGCAGGAGCGTGATGGGCATTTTAGCCCGTGCCAGTTACTCTTGTTTGTTGCGGTGACACTTTGTTCAGAGTGGGGAGAATTTCCCACCGCCGGTATTCTGTCCCTGTCTCTCTTGTGTCACCTAGCTGTTGAGGGTTGCCTTGACGGCGAAAATGCGCCCCGCCTCCTCCCCCAGGCCCTGCTTTATGAAGCTTGTTGGCTCTTGTGAGCCCCTATGCAAACCTTGTGCCTGCATCCCTTGAGCCGCACCCACGCCCTCTCCACGGCTCTCACTTTAGGAGGGAGGGAGCTTGTGCTTGAAGCAGCGTGCACTCCAGCAACCATCTATGGCAAGGAGCGTTGGAGGCTCGTCAGATGGGGACTCGCAGGAAGCCCGAGGTGCAACCTCAGTAGAGGCAGCACCTTACGCTTCTTCGCAATTGCCAGTAACAGCTTTGCATGGGGATTATCGCGGCAAGGCACAGAGGGCTCTGGCCAGCCAACGTCTGGCGGGAGCTGGGCGCGTTCAGCCCCTGGGAGGGGGAGCCTCTGCGCCAAGGGCTGGCTGTGCTATGGCGCGGGCGCAGCATTCTTCCGTGTGCTATGCCTCCCGCTCCCACCCTCATCAGCGTCAAAGCCTAAGCTCCAGCGGCCGCAGCCTCCACCTTCTCACACTCACTTCTTGTAATCTGCGACATGGTGTCTTCTTACTTTCTGCCTGCGTTTTGGCTCTTCTAGACCAATAAACCCCTCCTTGTGTT + ))*'*)-'&&..#/.&./.-/,."+)##.-..-,%#..$.-#$......--$)$....(,#'$,.,'./.#...&''.#,..).$%,#&*%(-(-,-&#+./...-%&-$-".*.$.(..#.")...*/+**.'"-../+..//)-,,-.+.,"$.*".$*/./).(./*".-*$%),%-.#"""++..).+)*%.*./.,,).//..,/*&."$.'.+."-,/,#.*,,',(.-#/+.//*.*)$()*.-$-$&'%')&+-#&..",$-.*+#-,*/(+."-%/(*.+'--""",-.*,+$..#-(#/).-&./*..('-(""".(...-+),*)+/%//...**&('.'.+$,).++',+#'*""&")&%+..)((.-$.&.#-.#.#-)')+*)..+...$.,-+*.$/*..%.-"+%'-$#&-.,"-)&)*&%-#)(-**)$*-#,(,,,%#-$""**+&$+-$.&,.+-.."*.#-+'+))+-+"&."").-.(."#).&.-,/-+,-#---,.&.")().,&+"--(#*%"&,**.&../..$$..(.)&%.'''"+-%#.-#.$)./-//./.(+&,.--"))(-**-%"#"*.".(-#,##"%$",#+$",%-%.."...%-#(#*#&),#"-,'"&&*++"..+-'--"#......$-.",#-+,#),+&")&--#",%""--./)/%+."%.,".-.#*#$----%&&-""-."-$",,-..*-,./..."".&.-.%,(./*-'".%$-%%$$+)$-"+")('*++"#(##-',)(*-*&&%##*'%'+,.#).")*""++(#&('',""+'$(",+*-(--+$"-,./(..%./*.,.%/..-.'*"*"***+$--&*$&+,+--)".+/.#-.+(,.*-$+*.#.,,).*+#(*.../+..,-.--"+.-,-.-..-../*-.*".,"/.-.$""-"#.*'-&"+#$+$-*-#(.,/+.+*-.+')#%$,,,+##),,"---+..),-%**,*,-%&***" @rCer/2526/1804_56_CCS ATGGGGAGGCGGGCAGCTGCGGCGGCGGGCAGCGGACGGGCGCACTGGCGGGCGCCTCCACCTTGCTCCCTCCCTGGCTGCCGGCTTCCTTTTGTCTTTCTGGGCGGCGATGAGCGCAGGGCCGGCGCAGCAGCTGCGGGCGCACAGAGGCCCGCGCTCCTAGTCACTCCTCCCGCCTCGGCGCGCTCGTTCCGGGCAGCGGCCCGGGCCGGCTGCGGCCGCCGCCGGCGCCGAACTTGGACTCGGGAAGCCGGCAGACCGCGTCCTGAGCCGGAGCAGGGGCATGGTCTAGCGGCCCAGTCAGGACACACTCCCCGGAGGTTCTGACCCACTCCCTCTCGGACTCCTCCTGGTCTCTGGTGTAGTCGCCGCCGCCAGCCGCCATGGGCAAGCAGAACAGCAAGCTGCGGCCCGAGGTGCTGCAGGACCTGCGGGAGAACACGGAGTTCACCGACCACGAGCTGCAGGAGTGGTACAAGGGCTTCCTCAAGGACTGCCCCACCGGCCACCTGACCGTGGACGAGTTCAAGAAGATCTACGCCAACTTCTTCCCCTACGGCGACGCTTCCAAGTTCGCCGAGCACGTCTTCCGCACCTTCGACACCAACGGCGACGGCACCATCGACTTCCGGGAGTTCATCATTGCGCTGAGCGTGACCTCGCGGGGCAAGCTGGAGCAGAAGCTCAAGTGGGCCTTCAGCATGTACGACCTGGACGGCAACGGCTACATCAGCCGCAGCGAGATGCTGGAGATCGTGCAGGCCATCTACAAGATGGTGTCGTCTGTGATGAAGATGCCGGAGGACGAGTCCACCCCAGAGAAGCGCACGGACAAGATCTTCAGGCAGATGGACACCAACAACGATGGCAAACTGTCCTTGGAAGAATTCATCAAAGGTGCCAAGAGCGACCCCTCCATCGTCCGCCTGCTGCAGTGCGACCCCAGCAGTGCCAGTCAGTTCTGAGCGAGCGGCCCCTGGACAGTTGCAGAGAAACACAGGCTTGTCGTGCCGTTTAAGCTTTGCTTGCAAGAGTGGATGCCCCGCAATCGTTCCTGCTCTCCCGGGCCCCAGGCCTGGGGCATGCGTCGCACCTGCCCGGCCCGGCGGCTGCGCCTCCCTCCTCCGCCTGACCAATGCGACATTCCTCCCCTCACGCCCGGCCCGGTCCCTTCCAGGGCAACTCCCAGGGATGTGATGACATGCAGGGTTCAAGTGTTCTTGTTCCAGGCACCTCCCGGCTCATGGGGAGCCCAGAGGTCCATGCCGAGGAGACCAGGCAGGACCTCCCGAGGCTGCGCCCCGGCCGGCCCATGCATTTTGTGATCCCAAGTGACTCTGTGGGGAGGGTGGGGCGAGGCGTCAGGAGGGTAGACGGGGAGCCCCTCCCGTGCATGGCTGCCCTCCCGTTCATTTTCTCCACCACAGCCGCTTGCACGTATAGATACTGTGGTCCCCTTTCTTTTAATATATAAATTATGTATGGTGAAGTGGAGTGTAATGTGTAGGTCCCGTATTTAATGCCTCTGACTGCCTTTGAAGCGCAGCCCCCTGTGGCCCGCAGTCCCCTGAGCCTGGCTGTTGTGTGGTATTTATGCTCTCTTTGTCTGCCTGTTTCTAAGGAAATGCATGTGTGCCCTGAGCCGTGACGATCCTCCTGTCCGTGTCGCGAGCACAGGCATTTGTGTCTGGTCTGTCCTCCCTGTTGATTGGTCTGGCATTTCCGGTATTAAAATGATACAATAAATG + HKKJK&DJ9IKKHKJIICEKK=JKDHHK)KKIKIHFKKJ%KKKJKJKHKKF/IKJDJJ>JIDKKKKJKK9KKK/KKGKFJJBKHJJIKIKJH5KKJKK;KKKJ7KE;KJ27JJIIKFHKKIKJKBIKKHKKKIGHKKKK@KIKHKKKKKJKK=GKIIGKDFKKJBKIJKKFKK%JK>KKK@IIDBIKIKKIKKKKDKCDJJ5KKGJK;K>KIKIKKKGKHKKEKKKK:FKKHKKKKKBKHJIJJKK7KCKK=KEKJKIJEKKJKKDKKJHKFK:IIKJKKK+JHKKAAGKHKKKKKK?BIKJKJEKIIIHEKKKK7KCJF:KFKJ@?KKEKJJKK?KK,DIKKHKJKKKKJBKJKDKKCKKKIHKKKKEHEIKEKDIIJK?KIHEKJJKBJCJJIKJKJKHKHKIKJKKKKK@KIKKCJGKCJKIKKKKKKHJGJKIIKJJKKHIHHGJKK,KKGKKKKIEGKKKKIKKKKKIKKKKGHEKIIFKDJKKJFIKKF=>JGKGKBKKKJKAIJCKKKKJJKCKKEKKKBJJJJHIIJHIHKKKKHKKKKJAGKKJKJKHGKEJJDCJIKKJKIBJHGKKEKJDGK(G;GK1JKKKHJHEGHKK-IHJKKJKKKFJJKFKKKIJKKKKKJJK:JGIGJKIKIAKCJGKK8IKIIKEKJK8KKKKKCK@KIKDIKEKJJBGIKKDKI;KFGFKH,JKCFCKKDHKJKKKJHKFJKKKJKGKKKKHK>@F&K:JI@KGJFKG79>K'JKAKK8CJ;KIIKBK>JKKKJIAKBKJFBCJKK)IKK?IKJIKIKJKKJKIKJIK9KKHK6GIKKJKK3$KGKKKK=IJJCIJK5JIEHKJIKKK3KKIJ?>DGKIHKJIHJGKKJDJK@KJK9KKKKKKKK5KAKJJAJKCJJKJJKKK=JKIIEGI3J@KIIC?JGIBD?IH&CKK+FKKJ4KJIKJJJJKKKKJKK5IJJ>KKKK2KKKKJBDHK)HGKJHJKEGBHKJD@9H.KKGKKKKKDIGKGIJDCKJCJ+KJKEJKFKKK:KGKJJKKHKBJCCKKG?KKFKKKJ=I6HKKI?GKBKIFJJIKJEBJIKJKJHJJKKGGHJ;IHKEFIJK7JJJ?KIEB-JJGJJHJGJIKK+EIFFIKJIEDFGF>JBIICIICJFJAB4HJE@G @rCer/2528/0_978_CCS CAAGTGACATTTGGAAACTTGAAGATTACAGGCCAAATGAGTGAAAGTTTAATTCTTCTCAAGACCCACTGATTTGCCAATGTGCATGGAAATAATAAATTAGAGCAGAAACCAGCAGGGACTATTGTATAATGGTGATCTACTGGCAGAACTGGGCCCAAAGAGAAAGAATTTCTCAGGCTGGGTTTCTTCTGGGAGGGTAGCAGGTTGGTCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTCCCCTTTTCCAGCTTGCCTTGCCGGCTCTGCCTTGCAGGCTCCTGCTTCAGATCCTCTGCCTGGGGTCTCCCTTCCATGCAGGGGTTCTGGGCATCACAGCTCCTTTTTTTCTTTCTCCTCTCCCAGATCCAGTTTCAGCTGGTTTGCTTCTCCCAGCAGGTACCCTTAGGCCCAGGGGCAGCTCCCTGAGAGAATTTGAGGCACTCATGTCCTTGAACAGCACCCCCTTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGGTTTGTGGGGAGAGATCGAGGGATCAGTGAGCAGTTTTCCCAGAGCTCCATGTCAAGGCAAGCTCTCCCTCCCCTGATGGGAGCCCCAGTGTCACTAACTGTGTAAACTCAGGCTCAGGCTTCAACTGCCCACCCCCATCCTCACATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTCATTGTGGCCAGCTAACTCCACCTGGATGTGAACAGGCAAGCAGAGTGGGAAATGAGTCACGTACTTGTAATCGCACAGTGTATCGGACACCTCCCTAGAGGTCCATTGGTTTAAAGAGATAGGGAAGGAGGAGGGATGAGACCATCACCCCCTCCCAGAAGTAAATCTAGGTTTTCTTTATGGGTTTTCTTTATGCCCTTGAGTCAAACTAATAACTGTGTCTAGGACGGAGATGTTTGCTGGTTTTCTTTGGTGTTTTTCTAATGCAATAAATTCATTTCTG + S//7;99/1+/248'22115605519<>68(11>=97)>A:8>;4?1>3*43;8<9;1=9,,7+/89>?<;6@>?=0A>6;69<509883/026;>;8:50;9<>A:CC-@@:>4<489289;5==:'.4<(67;;?@==>8A5>@<87'A5=3>9@1+/8669?6483(35:;9&29=+223,7773/718787+23:6/./7=@89?9D:?>9A4A@?48<9=885:8:0$:4<4::=7839=:3469<>::?>;3>9(:7918:3/578868-:2<675:'315:3(,&457;<87;98:>9265.8591:=7:;.942+:8979<55/:549;70-58.5167:7;7?7:0017;6?;<$:9:<@<@@9<;>:=677;?>>?A9)64/*.1(5.42:8%.(.7.8508985<:::0;624(75722163-5+188=6309712+1.$20,317979216/22-*-1<:6A6:::8;?68.59<05;A:5@8/7;28>>81/=A=8=8:05/,.13/78:6<;;18>9<587=2/50++0+(&50*2/34(/0,1567B@?979<26;76774>,*061.516>76?=78025958<4/0758(:7+38<:74563:=;11,2:94331344:8>8:,22=962535=9;=;;6596812-.*3038>;48<292/294/*6-3846495*572$-8=7;:16838657;=9-;7*0/04245;/8>8+78.:3?565+28=59=:2,8:5:36(:65389283505,2-585'1/575,3*5<;7;6+:706/60844=88552-8+27/8:4;6>71+40<:5:;<;9;4:65;1790499;1*.7/5=;=96<4779>4=98;=38.77:078?6:81.298934*<7=8'61)461883.3;998 @rCer/2530/1982_64_CCS ATTGGGGGGGCGGCCCCCAGCCCACAGAGTCCGCGCGGCGTCCAGGGTCGGGAGCAACCGCAGCCGAGCCCCAGGAGCGGGCGGCGTTGCCATGGCGTGCGTGGGCTGCTCACCGTGTGCCTGCTCCGGCCGCCCGCGCCCCAGCCCCAGCCCCAGTCCCCGCCCCAGCCCCCGCGGCACCCGCAGCTGCGCGCCAGACCCGGGCCGCCGGGACACGCGCTCTTCCAGGACGTTTTCCGCAGAGCAGACAAGAATGATATGGGAAGCTCTCATTTGAAGGAATTCCAGAATTACTTTTGCTGATGGGGGGTTCTCAGCCCGGGGGAGCTGCGGACTGTTCAGCGGCATTGATGGGCATCTTACCGGACATTTAGAAAACGGAAAAACTGTGTGACTACTTCGCAGAGCACCTGGGTGTCTACCGGCCGGTGCTGCTGCATTGGAATCGCTGACCGTTCAGTGCTCGCTGCCATGGATGCCACCAAGCTGGCGTACGGAGGCCTCCAAGGTGGACCAGTTTTGTGACGCGCTTTCTGCTGCGGGAGCGGTGAGCCAGCTGGCAAGCCCTGCAGAGCTCGCTGGAGGGGGCGTCAGATACTCTGGAGGCCCAGCCCGTGGCTGGCGGTCAGATGCAGAGAGCATGGAGGCGCAGAGTAGGCCCGCGGCAGCCGGCGGACAGGACGCCGGGCCCTGAGGAGCGTCAGCCGGTCATCCACCTGGTCCCCTGGCTCTTCTGACACAGGGCACAGCTCAGAGGCTGAGATGCAGTGGCAACTCCAGGTGAACCGCCTCCAGGAGCTCATCGACCAGCTCGAGTGCAAGGCCCCCCGGCTGGAACCCCTGGCATGAAGAGGACCTGGCCAAGGGGCCTGATTCGCACATCCTCGTGGCCCAGAGGCAGGTCCAGGTGGCAGAGGAAGGCCTGCAGGACTTCCACCGAGCCCTGCGCGTGCTACGTGGACTTCACAGGGCCCACAAGCCATTGTCTGCATGTGTCTGCCAGAAGATGCCGACGGTGCCATCCTTCACCCTGTATGAGTTCTGGCAGGATGAGGCCTCCTGGAGAGGGCACCAGCAGTCGCCCTGCAGCAAGGCCTTCCAGCGCGTCCTCATCGACCACCTGCGGGCTCCGGACACCCTTCACCACTGTGTTCTTCCCAGCCTCCTGGTGGATAATGAATAACAACTGAGCCAGACCTTCACACGCCGAGGACCCCGGGACCCTGCCTCCCTCCCTCTGGAGCCTTCTGCCCTGGCCAGCCCACCCAGCGCAAAGACCAGGCCTGCCTGCTCCTGGACCTGGGCCTGGTGGAAGGGCTCTCAGCCCAGGGATCAGGGACTGGGCTGCTTGCTTTCTATTTATTATTGATTTTATTTATCCATGTATTTTATTGTTTGTCACTTCAGCCTCAAGCTACTTTGGCTTCTGCCTGGCTCAGGAGACCTGGATTCTGGTCTCTCCTGGCTGAGCGACCCAGGGCAGGTTCTGTCCCTGTGTGGGTGGGCCTTGGCCATCTGGCTGCCTAGCAAGGGTCCTGGTTTCTTCCCGCTGTCTTTGGGGCCAGGCTTCTGCTCCTTCCCAGCCTAGCAGCAGAAGCAGGGCTGATGCTCAGGGACCAACCCTCAAACTTTGCCCCTGAGGCTGGGCTGGACCTGGGTGCCCCTGTTGCCCTCCCAGGCCACTAGGCTCTGACTCTTCCAGCACCCATGGATGTGCCAGAGGCCTCTGGGTTGGTTTGCATGCCATTTTCTTATCATTTGCATGCCTCACCCCACCCATTCTCAGGGCACTATGGGAAGCCCAAGGTGACCTGGCCAAGTAGCAATAATTTGGGCCCAGGGTCACCTATTGCCCCCAGAGCCTCTGAAGCCCAGGCTGGGACCCCAGCACAGAGGCAATAAAGGCAGTGGTCCCTTC + &#$(('&''$')%((&(%('))##&'&$%'((%"#'%&)())(())'(()($'(()')(('%(($((%'''$#$$&&()(%%)('"''')((')('%$(&(&%)%&%(((%((%((((&%$%(''%#%#&#%))'''%))%$%&'''$%$&('%((&$')%&(((#&()())'((#&$&(($(((((%#(&($%##%''$"()$(%'%%%&#%''%'%%#'(%%&$&(%%(%%#""$""%((%'%(%''%&()'(%("%$((#&#$($%($&%(#)'#&$)&+'.+')-,-((+,,+&,-,)('$$%###(&+,-,,*#"&&%)#*++%(#&'&&*&+%+,((-+(%((,+((*$(,-'$($(*-(),#&+&+*'),%,-)'(*(#%*((*--,+%(,+'(,,)+(,+*+'$+.*)(&,(+.,,-.,*)*,+,'&+,,(,&--*)**+'&)#+(,%"*,-)+-+()%,,+%&*(%(),-*,(#(((,++)(),+($&',$'(+-*(#*&(,)++(),,*##&$((+--,,($"$&*&*,',*%''(*'%$#%'$&%)*%$+**)*+%+-+),+)&((,%+,++,-,-(,-,*(-,+&'&#%+%),*++%'#$,++)*'##'&%(%''(*'(&$&(&%'&,,-'&,)(%$&'$%'%&+%+*#%''&))(%(''+'%-.&*&%-+-,-,*)-+,-,+.*+-.(,)-1/2-*)*)10/-,.+(&)+'&-/)/+(,%'-+./-00*-,.,01+,0)),*/),+.0/0-*().+-+/0+.++(+/(+)*$0/.1)*,%*0',0.+.*11001--(',*/,),,12*2./++**&.&(-*(*%%$'',(%-*)00*--1,*2..2/2.*%+,.(0%./..'0,.0/,01*()).*$(,&**+$"&(0-0/*)&&),)110,-+,'-(/(()(+0,'$%##%'+)+.'-,(()%$$"(&*+(-)++*($&%(),),.(),&""($+&%(,(/-+)+0,',))%/+',()*+(.-+%+$#%('$*,+*#,/'-+.+,0+*,-,'+0..).+0'+*,'-/+,+(*)+-'&+%.-$#'$,'&*0-,)+(&01.*,+,,,./)++2*.-2-.,0.101-11.11-',0-02+'&$(()).0-0(+/0(+('$-.)%,0/01/-'.2..--112/-01021/,.+&,&.+,*.2//0)/301/1//''4(+0)-2*34//.--)..0/.-/&-,'%&-0,/.0'32.(-0/-,,+4.1+01*+*&+-150'+,--1-/,''/.31/-0.01/2'2-(/2//.00.0+60%.,,55%---522,**))'%',.01-.6631/2%),(-+/'$0/0)%/0%2'++00&$-&/(++/1*)*&*)'%$"$*-%/..,-*.'+,--+---*1/12/32.212,*))*$3.44541/,'1011/+*1425602441+,/+/5/5-/,-&&%-+0.1*/1'16*/+*/420)05-510.-15/1/.,1/,+&*,/.,2-&+.0(1,&$.%%%%%)*&$.-+,(..+)-'41*&*&)0(1-*2/0261/1(-%(,+%-10***)1,))'-.2,/.20)36-*1/%0020215.56154056-3'+0'00,0./1+/1&/++*%,%(,%,+/'%+42*,54/0.-,0.115.505661551211.&+*&54*,366/..+0/*42*-&+11-2(../3-64/22-..,/.5)14.*,1'11.21603412--3+0,-.%.1*020***,4%14*-/0.0.'.3(,'/(21+/0/+*(&$(.%),-(*3,2-/,'0-1(2-,-0(,+101.*)*/6/3(6,5.40$2*'.((,%2/,).,*-0)04140/0-,2*'*0)2.0(.,114/3'.46341-405(.0.&(%.+-*30//5/211121-6/1+++0/*14.60/ @rCer/2531/1764_59_CCS AATGAGATTATCGAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATCAAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCCACAATGCTGATGAGCTTTATGACCGGGATTATCCATCCACTCTGTAGAAGACAGACACAAATGCTGCTCAGGAAAATTTGTGACAACTGATTTGAGCCATGCTTTGATGCTGCTGACTTCATTCGAGCTGGAAAAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGCATGAATGGATGCGTAGCATCTGCTCCAGATTACAGAGTACATATCATCTCCTTTAAAGATCCCAATCCCATGCATATTGATGCTACCTTCAACATCATTGGACCTGGTACTGTGCTTTCCAACCTGACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACTCCTCCAACACCAATCATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATGAATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCAATGAAGTTCCAACTCAAAGATGTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCCCTGGGAGGAGCTTCCACTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTGCAGTCCTACTTGGACTGAACAGGCCTGATGGAGCTTGTGGCTGGCCTCAGATACACCTAAGAAGCTTAGGGGCAAGGTTCATTATCCTGCTTTGAAAAGTGCATGAACTGTAGTGCTTTAAACAATCATCTCCTTAACACAGGGGTCGTAAGCCTGGTTTGCTTCTATTACTTTTCTTTGACATAAAGAAAATAACTTCTGCTAGGTATTACTCTACTCCTAAAGTTATTTACTATTTGGCTTCAAGTATAAAATTTTGGTGAATGTGTACCAAGACAAAATTAGTCACCTGAGTAACTTGGCCACTAATAATTAACCATCTACCTCTGTTTTTAATTTTCTTTCCAAAAGGCAGCTTGAAATGTTGGTCCTAATCTTAATTTTTTTTCCTTTTCTATAGACTTGAGAATGTTTTTCTCTAAATGAGAGAAAGACTTAGAATGTACACAGATCCTAAATAGAATCAGATAATCTCTTTTTTTTATAAAGGAGAGAAAGACTTAGAACATACACGGATCCTAAGTAGAACCAGGTATTGTCTCTTTCTAATAAGGAATTTGGGTAATTTTTAATTTTTTGTTTTTTAAAAAATAACCTAGACTATGCAAAACATCAAAGTGAATTTTCCATGAATGTTTTTAATATTCTCATCTCAACATTGTGATATATGCTACTAAAAACCTTTTCATATACATCTTACCTCATTTCAAGTGAATTATTTTAATCTTTTCCTCTCTTCCAAAAATTTACAGGAATGTTTAGTGTAATTGGATTCGCTATCAGTTCCATCCTTAAGTTTGATATTCAATATCTGATAGATACACTGCATCTTTGGTAATCTAAGATTTGTTTACAAATGTGCAAATATTTACAGCATAGACTTTATAAGCATTAAAAAAACTAATGGAGGTAAAACCTATATGCGATGTGAAATAATTTTAGTGTTGATACTGTATGTGTATTTTTATTCTAATAAACTTTTGTGTTCCAGAC + 6,433100,,-2416./*08)7494407323,;1::8533'5.1.7.7597%+-2746(0352/55.85*-611'--34145..+3/%-55-/3636)+52*-93954.$(/+34-,4:,61:0&#,.-&*200765&0.74//)+$3/&++9$632064+21..3'220(-5+2-2*53$%%252503*-)589&&,%*(/86+)/1-$,0)1(1)&*.248:+45#+1*66/02//'-(2'112*703.;;2)*0242264(69250,358&55+144936767-35)6.4/'81%26+371473=;63(3374$/8*530&2923<569;8936315484226)8<2>=.529=>8>979:+7>8083;?::9;<856957227';,9=9,>@73&273?0=2;*>&<8;7%B@=:F>BCABF7ACAC:E<=D;3>/85&):<-<>78.?9D8?@=64/:F:4:4+%9FCD36;>+@2,?D>>F,BAAJ?<>93B5JADB=>:A>65DHCG&FE<>G:>.H?>>(E=9%<;>=;;?C(C1G?BD:BE$@@:>EE0*6FH-BG9GG4CD@DDBI3DA?>?4B5;H8HJF+AE=A$$?H?===8F:FCEFBC&?F@GK?F7=3:AH87C?HB@CEIF0GICEHCAA)FBGCB34@@@D6ED7C>3C8D8C>@6G2F8=@9>0AD9/HDFHIFEGI,;:F95%3,'>>AH<@GH3AH9DFH,<;:*98*D5FI9EG;GDD?=DG&DIG/ICGKJ820:0:3HAH>JH?A(CHCDIHDG4>6CHK1B6>;@FHJHGH*G/JKI)JIA=AFF:J@EH:I;E@EHIE.DD?AEH9A=A7::BJ9CAAIACCBH3<@@>?ACF?CB9GEG:DDA=6:DAF?CB;?>/3GJKKIJH+6:DD/E/6%;&FC4DIGE1KEEFK?AH:A?>0>9IIKFFHDCJ9?GEGHI4IEAJJGAGBJC;FHICAE=:@;$F5.5FEBFDKDG?-5<@F9:?H;AC/B;AHDAIJDHFGE7E4;?FH5B53EB<2&F;CF99G&9;GKDJ9F;JD=F*;B7(;=HC,J:D+HFA/H==:E9G;CIII0AB5,79FH6F@ADEH?9(=A?2BB6C69HGD;AEF=A?>6?C>C=DFFC?>%A>I4*E=;A08@HI%J9BED94CFI8BHBGK8AB:>?=:837GHC;CE@ED:FB?CA?AC0?EDC@>D8FEFCABA;B6FAA>ECEAEABBG@BBC$>@C?;?AB7EF7?/>@;D=>GEEGC?;AAD8@A>@?CFAB?BCAC:DCD@CBBCF1;B:4A;<7-/>@@=<<4C;AD>>7CB?A?CDC?=CFEE;@=9:B?DBFD5=;A@B3B=B;>B?7FABABD?86@EDC92;?<><<9@??@>C?>6>8AB@:/C?9@=@A=<><+>??;ACA53?A@@?A@)>?@2BA=;8=5>:;>2@?<76>;B=506->6A@?9B?;?359@==?A0@<=>;??7/;.@AB;=AA;;B9C@B9@:?=;?C;>A;>B7@;?A9A>@?5<>>?BB>CAA<<@?;=5=;?<5BA?7@5=A=:8><;56A@A;8:@>A@B879<-;=B?:;;01@??AA>BB:<>9;69???6?=>>9?@>?>;/9BACACCB=;:@A:==A<6B><>@(@==?=?A=A?A8CAB<@>5@DFD5?D?FGGCDB33DGF;E@EEC=BEBE>/B@@BADFEBC@@ED=:@C7FBBB1C@9B@0ADEAFEB=C?33=D??F@9?BC=C>?AAC4D:EA:EFG??C?3D=EBBDGE?D;=9>>>?FEEAEF=B?B=7AA@C3@>B<9>4CCB=C6@AEE5;?A+B?@@=D@AA@AA7971A>A=;=C9;+EEGDCEE@5A<=62>D@;@3:9<;A?<6A?B8@A@?EE8C88E=>;=(B??ABB<:9A4A,C8AE4=DD=<;AFF>>A@6DF??DEEDD'D9BB5C@E6?C;A>>=AFD@CEBEAB@,FBDB<;?DFFDBE<5DED>:@@C6@CEG?C;ED=B:AD<@?@:GB8A=9@@@A@4DDBFCBEF>GBC=;BGBED@>>B2B;>E>BCF>>=AFC?2CECGC@?ACB?@4@D=20AD@B>@55ACAA'=:=A>@EAC>9A@73CF3EG7GD:@9EAECCBC@69A9A>?AC=?BE7:?<9@CBDDD=ED?ABC4E;BB76.CDCD7?D6E1@BD@:CC@F@@=3B=C4ADD@9EEGEFG@:FEG=ED@AE@C@EDGEEF=CEGEDECBBCF>B?C>EFCCAFC9D?D<>2DBBB=A4D?FBBBG?E4@@37?DAAGDDCBD?B=A=CA:C?=763B:?B>CEGG>E>FEE=EEGEABA$BEDA@E@CCB:7BF8BA?7DDED:>>=D>GC@AE8<<9=8?A@9?<==6:5AC@8@D>A?@7@BF3BDDABCGGDBCB,EEGBBBDC7EEDGACD1EDE=>ADA=D3B>CCDEEF:9EFEE9CDEF?FC?EC@DE&GDFEEDD?:F;CDEBCCCE7<>=8889@C@GDGE>B/DF@AE;A5CAD@DE?DE;C9>>9?:?EAECCD=C?=AC8=E>=EBEEBABAB=@9?;E@>E;?CE=>:?;EBA>D<;>9CFE<;:A=BCDF?A=D7>7EE@:C*DE>?CA-EDEFFGA>83>?;DBFE:ECD:5D7EGACEA2;<>:DBEF?AE?DCC?7DFD@C7BC=CG?CCECECC?-B?BABFAE@@EF@A8;)AD@CB>FE?@GDBCDF;8=A:@DEDBCEBEBBAA?9=)G>FDC?D7=@F7A7;@4AEGE@>;?@?>8;@AED?C?::;=BCF?7>=B%ADFCA@8FEGE??GCEBD2EE?@>?;DBE;B>?<;EDDE,EC:BAFF?GCDFCEDDF?EEGDFB@CA1EB>A3D>?C?FFCE?CEGFGFEA=F@DGGFDDA?E=BDD?C@8DEE=D?DDC?9@@DB9C@69D?F?F;ACF?BB:F<@B;EFAA4D=C?>GDD@DECBAD:FCA?DGFEEFCEDF8G?BGFCA<>E?FEECAEAGABDF?FGCECEE5@GA?=BBBE9:BD4D6::4@B;:A<:833E>BFBDB@CC>ACC?BE9BDDC@<3BEDC:E5E>BBD;>:>%E;9,@C=DBEEB8ECA28:9BBD9AE>ED?5>EB4BC4BCEBBGEEBB>DEECB3@BE?A?G?@@8AF=>GEEE3>B=E@;B?@B@>=$:CC5A5ED0E?BFABAD>5-99=7D @rCer/2534/25_2288_CCS ATGGGTCTCATTGAACTCGCCTGCAGCTCCGGGGGCTTCTGTGACTTTTGTCTTTATCGGAGCCAGGCTTACACGCCAGCAACCATGTCCAAGGGACCTGCAGTTGGTATTGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTAGAGATAATTGCCAATGATCAGGGAAACCGAACCACTCCAAGCTATGTTGCCTTTACGGACACTGAACGGTTGATCGGTGACGCTGCAAAGAATCAAGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGCCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAGCATTGGCCCTTCATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATATAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTATCCTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTATCTTGGGAAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTATTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTTATCTTTGACCTGGGAGGTGGCACTTTCGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTTAACCATTTTATTGCAGAGTTCAAGCGCAAGCATAAGAAGGACATCAGCGAGAACAAGAGAGCTGTAAGACGCCTTCGTACTGCTTGTGAACGTGCTAAGCGTACGCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGATTTCTTCAACGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAAGTCTGAAAATGTTCAAGATTTGTTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTAATGACCGTCCTTATTAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTCTATGAAGGAGAGCGTGCCATGACCAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACGGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAAGAGAATAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTCCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACTATTGAAGAGGTTGATTAAGCCAACCCAAGTATAGGTGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATTGGCAC + JIIKKCJJIJ7JJIKJJIKKKIKIEKKJKKGKIKKH7HIKKKJJG?JJEFKJKKKJKKGKJHHKDBEIGKKIJHKCGJIHBKCKIKJKGJCKGKED>JBJI;HAKIKKK=KJJIJDK?IGIKKGJKJKJKKJKJKKJKKKJJ=JKKKDIKJEJDK*GGEIGGHJJHHHJ8CG@JDKKKJIHKBKH9KIEKGE?IKJGJB@KFIC(IIHHKJKJIDJJKJJHJKIEKIGEDHKJKFECKHKKJJGEEKKKKJKIKIKEKKFKFFIJ/JGDKJHJKFK(JD4G?GEJH.KEFJAKJIG?IB?IJ5KJJJHJHKIJJJKH6HFHJKKKJHIIIIJIGKKJJJKC@DIK0KKKKKKIGIKDJKJK>IKIIJFGIIHHKJKJJJJKKKGG=KHJK@JKJJKKKJKJIKHHJJDIKH@IGKIHFHK?HJKKJEKKJKKKKIAJKIGEDJJIKGIHJAIKIKJKKK@IH2JJDIJGKKCKHKDIJJJKJKGKHJJEDAJKIKIJHICHEIDHDJJGHHJKKJID5GKKEKKKJHKKKEIKKKKEKKKJKHGKJKIKJEKGJKEKKIJKKKJKCKKHJ/KKJCKKCKDJJDKHKHGKDGKJK=KKKKKKKKGIKKKFKIJKKKKIJJKKHKKKCKKKKJKJJKKEHKDKKKJGGKK@KJKIIKHKK@KJHKJKJKKKKCDKIKKKKJKKHKBKIKAIKKJJFJ=KKKCKKJKKKIKKKIFKKKK=KEKJK7KKIJKKIHJJJ9KKKKKKKKKHK4;JJ5GGKKJKKHKKKKHFJHKIKIKJKHHDKGGGKKKKKJKJKKJJGDEEDKJKKKKKFK@JIKKKKKKIKKHA?I=JKKKJKKKKKKDKKKKGKIIJJJKGKFKKKEJI=IKKI>KK>KKDKKKKKIKI;KKKKJKKKJJ8IKJKJKIKKKKJ?KHGEKIKJKIKDKJHJKGKIGGKKFIJKJGKKJJKK8KKHHKKKHKJJKKKKKIJKKIIFKGKIKIJKHKKHHKJKKIIIHI8FKKJKJKHIKKK9JKJ5KIHJ:K@KKIFKKJKKJHK8KJJKJIKFJJJKKGKJKHJIJKBBJKJKKIKKIKDKKIIKJ1KKKKIC9AJKKFJKKEGK:KJJJJHKKKKF8FD=KJJ>KKJJKD@KK8KKKDFAKKBE @rCer/2535/2204_60_CCS ATGGGGGCTGTGATCCGGGGCCCCGGAACCCGAGCTGGAGCTGAAGCGCAGGCTGCGGGGCGCGGAGTCGGGAGGCCTGAGTGTTCCTTCCAGCATGTCGGAGGGGGAGTCCCAGACAGTACTCAGCAGTGGCTCAGACCCAAAGGTAGAATCCTCATCTTCAGCTCCTGGCCTGACATCAGTGTCACCTCCTGTGACCTCTACAACCTCAGCTGCTTCCCCAGAGGAAGAAGAAGAAAGTGAAGATGAGTCTGAGATTTTGGAAGAGTCGCCGTGTGGGCGCTGGCAGAAGAGGCGAGAAGAGGTGAATCAACGGAATGTACCAGGTATTGACAGTGCATACCTGGCCATGGATACAGAGGAAGGTGTAGAGGTTGTGTGGAATGAGGTACAGTTCTCTGAGCGCAAGAACTACAAGCTGCAGGAGGAAAAGGTTCGTGCTGTGTTTGATAATCTGATTCAATTGGAGCATCTTAACATTGTTAAGTTTCACAAATATTGGGCTGACATTAAAGAGAACAAGGCCAGGGTCATTTTTATCACAGAATACATGTCATCTGGCAGTCTGAAACAATTTCTGAAGAAGACCAAAAAGAACCACAAGACCATGAATGAAAAGGCATGGAAGCGCTGGTGCACACAAATCCTCTCTGCCCTAAGCTACCTGCACTCCTGTGACCCCCCCATCATCCATGGGAACCTGACCTGTGACACCATCTTCATCCAGCACAACGGACTCATCAAGATTGGCTCTGTGGCTCCTGACACTATCAACAATCATGTGAAGACTTGTCGAGAAGAGCAGAAGAATCTACACTTCTTTGCACCAGAGTATGGAGAAGTCACTAATGTGACAACAGCAGTGGACATCTACTCCTTCGGCATGTGTGCACTGGAGATGGCAGTGCTGGAGATTCAGGGCAATGGGGAGTCCTCATATGTGCCACAGGAAGCCATCAGCAGTGCCATCCAGCTTCTAGAAGACCCATTACAGAGGGAATTCATTCAAAAGTGCCTGCAGTCTGAACCTGCTCGCAGACCAACAGCCAGAGAACTTCTGTTCCACCCAGCATTGTTTTGAAGTGCCCTCGCTCAAACTCCTTGCTGCCCACTGCATTGTGGGACACCAACACATGATCCCAGAGAACGCTCTGGAGGAGATTACCAAAAAACATGGATACCAGTGCTGTACTGGCTGAAATCCCTGCAGGACCAGGAAGAGAACCAGTTCAGACTTTGTACTCTCAGTCACCAGCTCTGGAATTAGATAAATTCCTTGAAGATGTCAGGAATGGGATCTATCCTCTGACAGCCTTTGGGCTGCCTCGGCCCCAGCAGCCACAGCAGGAGGAGGTGACATCACCTGTTGTGCCTCCCTCTGTCAAGACTCCGACACCTGAACCAGCTGAGGTGGAGACTCGCAAGGTGGTGCTGATGCAGTGCAACATTGAGTCGGTGGAGGAGGGAGTCAAACACCATCTGACGCTTCTGCTGAAGCTGGAGGACAAACTGAACCGGCACCTGAGCTGTGACCTGATGCCAAATGAGAACATCCCCGAGTTGGCAGCTGAGCTGGTGCAGCTGGGCTTCATTAGTGAGGCTGACCAAAGCCGGCTGACTTCTCTGCTAGAAGAGACCTTGAACAAGTTCAATTTTGCCAGGAACAGTACCCTCAACTCAGCCGCTGTCACCGTCTCCTCTTAGAGCTCACTCGAGCCAGGCCCTGATCTGCGCTGTGGCTGTCCCTGGACGTGCTGCAGCCCTCCTATCCCTTCCCCCCAGTCAGTATTACCCTGTGAAGCCCCTTCCTTCCTTTATTATTCAGGAGGGCTGGGGGGGCTCCCTGGTTCTGAGCATCATCCTCCCCCTCCCCTTTCTTCCTCCCCTCTGCACTTTGTTTACTTGTTTTGCACAGACGTGGGCCTGGGCCTTCTCAGCAGCCGCCTTCTAGTTGGGGGCTAGTCGCTGATCTGCCGGCTCCCGCCCAGCCTGTGTGGAAAGGAGGCCCACGGGCACTAGGGGAGCCGAATTCTACAATCCCGCTGGGGCGGCCGGGGCGGGAGAGAAAGGTGGTGCTGCAGTGGTGGCCCTGGGGGGCCATTCGATTCGCCTCAGTTGCTGCTGTAATAAAAGTCTACTTTTTG + =?A>BC87@@/?E@9B@B7@<1BGCE@E=FB.2>G@?B?@7B,<=>EC@=A7@@DEE@<;G;>@B7>@EA=0;=ECG=DDB@FFBCA>8>;9/(&-&@>3E;=1>@:)BD?B@@EF?E;CDEA@9;CAA:BC?7?B7EEEABFB<6=ECB@7AA>=@6:?@=:>6AD>CA?:B9@EAB=>B7CBEGB4;C8<6:C6C:CB=;@BDB?@9BCD9ECB<@D><5>A3>9>>?:CD>4=8;7:<8:B@>@ABD=D=>=E?9,B:C9ADCAE@97BEEA>BBBEBFEDG@GBC?FF@CB>FEC?E?@@E7A@:=E@C9?1:-58;D=C?;A9;?5EBFAFCCFC4D;?BDECEEBCB7>EE>28E>;@1;;8<92DAF;FA;@?;@4;?DFFDBBEDD-C?B<=>?,A;@8BDA@8BFD@CD-CACCDAFF=8+==>D?9EBBD@A?B;?FB?>?C@45C6D>>?C@:=C.;<@8B1AC@CB:?;/7@A@ABD9;9+1EEAAE5B:BB5A8@BBBEGCE>:AD=>A4:@B>;EDDD>@@>78C<>90BA?BBFBEG>:F;E?A>B;>:ADB77@;=A=@C;EDCC.=@8EB:D>B@<@BB44?@6EA?BAD:C>>???:A69*C9+EBCE9DA71DEDCA*@ADBDC@8>EGD@>DDA:<@8:8ECDED>EF=FBCFG=EFBC<<76D<:=6AB8A>@98ADDDE;?A??CF??FEEB?BC;B>=>B@9B;FCB7A8=D4BDD:<<7B><6=,<7755<997>B7FCFF@G?658:A@$>DAC=9B=BAE>B;>B=@D3CCE6A?GFD?=A87C1?B6;C@BB&A?77DBB7@=@?=3?FG876?>E>EDC>A8E;@>=72;A?E@@3>=D;=@CACD@1@::D>FA:FAA>?;E@BF6:B?:C?DCDDDA>FE@@95BAC);<==<=;C:@87E@F?>?F?A7BA>F5D<:;?;F@:>?=4DB<7:CD8@;<77?@>=:A>'7?8C8BADB3AF@C>D@?C;B?AD4;DC@=C:DD,A89=@6=D=>A?FB<=55A?B==89&=A382C0?B@ABA9F;4/3@=:C8B>EE:BA?<899>77:>A>@:9>C=<8B?@EC3?4@>B1B<>BB86?<9AAF?=CDBC5B<:D?<9:9A>>=87<<+<@?>?BABB;?C:C<69B9C;B=?@AB7EBDCEEG8E=A>7C:CAA:C724>FBCD?:=BE7;>CEC5?;?=$BAFCCA77+:AD4@1E;CAD@EEBBE9DEACB?>7EGCABCE9>0?5DF?IDDD<5C;9>?7>:%>A,8+>D=BC/AB385.?1@8FAACA>@JH;EA9A<@2:GDFEB?>1C@@?B;C;>C?DGAGIABECEAC%A99CBCGBDEBD-GHGEG@@CEC+2 @rCer/2538/1741_52_CCS ATGGGACTAGGGATGCAGATGGATTCGGTGTGAAGGAATGGCTGCTGCTGCCTCCGGCTCTTGAAAATCAAGTTCAGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACGCTGCTGCTGTTTGTGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGACCAGACAGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAACGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCTGAACTTCCACGCCATGTTCCAGCCTTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGCATCTGAGTCCAGCTCCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCAACTTCGCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGTG + EIKF)@KKIKK:J?BKHKJJKJKJ?DKBJJGHKIKJKJKKCKKIJIKJJKK7GKIK8>DKKICJIK-JIK;IKJJJJFI=KFKHKFGK8KJKK=KKKCK9JCHJ4GKKJHDJJIJ@AKIFJGHKGHKJJEGHJK(JHJIJKJJJGKJIKH>IEBHKKK*JJKIKK>KKKK4KKGJJKKJFKGKAKFJJKAJJE=KKK9EK=IG:CKIJJKJHIHKK>KEKKIHJKJKGKJI=KKIKBKK=KIJKKKFKEJBIKKK4KKI?&@GKK>KKHIKKKEJHDJKJJHKJHKJK1IJJKKDKFKFGKJJKKK?GJEKJGJJ>KIIKK?KJ?IKKKFKIKKCJ=FKAIKIJKHABEJGGGJKKIHKKKKFIJIEK@GHHHKIECIDKKJHKKKJJKHJKKJJJK%IKKJDHF9AJIKKKHJKDJJJJJJGJKJKDJGB4FKKEKAKKKKIKK;J(9CKKKKKJKK9GK:F,H&..KJGIKHBJEKKK5KKBKGGKKIJKKJHFEIJ7IEFHKKIKJHKKKHKKF68GGI&JKJKJHKI$KIK>JKJHIII#B>K9KEFKJJIFGKHCJIJKIIIKJJJJKK>JDJGJBKIIJKFJKKJJFIKJHKI=KCJ4KFKIKJKGIK8HJK?JJKJKGKDJI=EKIJJJGGGKKKJKJIJIK9K8JKJKJKKKK?KH9HJJKKHAJIJKKG;JKKJJKKJKKKKBKKKKHKIHJIK2HKKK;FDEIKKKJKDJKIKKBJJKKJKEFJGJFIAGFGJIJGK=KIJ2KJFEKIK@JKJKFGK@IJK>FF;KBKKKJKKKHK@EJKHFJJJKK@CKJIKIKKK;IHEJGJKKKIKFEGIKJKJJIIHHJJDH@9F@K(=HAFE=GKEIKEHKEKK5=HHHK@IJJG,HHBKG9CKEJ@JJKGJDFJJHHJKJJI@JI-HKKJKKHGIJKHK9JKEHJKKKJKK)FGJKJJKKKKKJEKJJ)EKFIJJGD@F;J@JK=KFIKHKKCJKKBKKA@JKIFDG$6G?BHGEBHHG/IHIHAJJHF.I-GDFKHGCDGIHK9EKGGKGKIIHHEJKAJ>JJ8B?IKIHJKIIK:HGKJKHJCHKFBHHJKHK @rCer/2541/1455_54_CCS ATGGGGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTTAATTTCAATGAGATCAAAATTGCAAGACACCAGCAGATGGAGAGTGGCCCAAAGGGCTGTACTGCCTCTTCCTTCCCTCACCTGTGATCCCCTGCCCTCAGCCCCCAGCATGTGGGATGCCTTGGTCGTGGGAGCTCACAGAGCTGATTCAGGCACTGGGGGTCTTGGACTGAAGGCCTGACCTCTCCCCGGGGACCTTACCCACATTCTCCCTCCTGGACAGGAGACACGGACTGTTGTTGGGGAGGGACAGACAGTAACCCATGGCATGCCCAGTGGCCTCCCTAAGAACGGGGGAGCTTGTGTGATGGTGGTGAGGGGATGGGCCCCTCCTTGGGGATTCCCATTGCATCTGTCACACCATCCATGCTGTCACATTGGTGGCTCCAGCCTGGGCTCTTTAGGGACACAAGGGCTCTTCTTCTCCCACTTCCAAGAAGGAAGGGGCCTCCTCTTCTGTCTGAGGTGCTCCTACCTCAGGGCTGGCTGCAGGAAGGCTGAGGCGGGAGGATCCCTGGAGCAGTTGTCAGCAGCCCTTTCTTGAGGGCCAGCTGTGTGCCAGGCCAGGCAGGGGAGGCTCTGATCACCCCCCACACAAGGAACTCAACATCTGGTGACTGAGGACAAGCGTCACAGTCCCTTCCCTGTAAGAGCTCATAGCCTAAGTGGGGGGTCGAAGTACCTAAAACCTGGTATGACAGGCGCCATAGGGGGGGTGCCTTCTACGTGGGATTTGTGCAATGATTTTTGGTGTTACATAGTTTTGGAACAGTTGTACAGTTCCTTGCTATTTTTGGCAAATGATGCTGGTCTTTCATTTACAGAGGAGTTGGGTGCAAAGTCTCCTTTGAAAAATTTATGTGAGCAAGGAAAAGGGGAGAGGATCTCAAAGACTGAGTTACCTAGATCACGTTCCAGGGGGTGCGCGACGGCCCACTTGGGCAGGGGGCCCAGATGTGGGAGCAGCTGGCTCAGGGCCTCGCTGGCATTTCTCGGAGTCTCTTAATGTTGGTTTTCTTGTCGGTGAGCAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCCGGGCCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTTCCTTTGTTGTTTTAAAGGGG + KKKKKKK1KKDIKKKKKKKKKKKKKKKKIHKKKKKKKKKKKKKDKKKKKKKKKKKKKGKJKKKCKKKKKKJKKKKJKKKKKKKKKGKKKKKKKKIKKKFKKKJKJKKKDKKKKKKHKKHKKKKKKKKKKK5KKKKJKKKKKKKKKKKKKKKKKKJIIKKKKIKKIKKJKKDKKKKKKKKKKKKKJ@KHKKKKKKKKKKKKIKKKKKKKKKKKKKKKIJKKKKKKKKKK>KKKGKKEKGGKKKKKKKBKKKKJKKKKKKKKKKKKHJKKKKJKKKKKFKKIKKK:HKKKKKKKKEKKKKFKKGKKKKKJKKKK>KKKKEKKKKKHKKKKKKKKKKK8KKKKKIKKKKKKKKKKKKKIKKKJKKKKKKKK@KKKKKKKKBKKKKKHKKGKKKKKKKKKKKKKKKKKKK9KHKKKEKKKKKKKKKIKKKKKKKJKKKKKKKKKFKKKKKKKJKHKKKKGKKEKKKKKKKFKKK8KKKJKKKKIKIKKK8KKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKFKKKKKKKKKKKKFKKKKKKKKKKKJKKIIKKKHKKKKHKKKKKKKKKKKKKKKKKK:KKKKKKKJKJKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKKKKKKKKKKKK>KKKKKKKKKKJJKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKIKKK2KHKKKKKHIKKKKKKKKKKFJKKKKKK6KKKJKKKKKKJKKKKKKKBKKKKKKKK?KKKK3KKKKK8JKKKKKKKKJKKKJKKKKKKKKKKKKJKKKKKKKKKKKK9KKKKKJJKKKKKKKKJKKKKKIKKJKKKKKKKKKKIKKGKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKKKKKKKKKK