@rCer/1/1823_55_CCS ATGGGACCGCCGAGACCGCGTCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAAGCTCGGCATGTGCAAGGCCGGCTTCGCGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACGCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCGATGGCCAGGTATCACCATGGCAACGAGCGGTTCCGCTGCCCTGAGCTCTCTTCCAACCTTCCTTCCTGGCATGGAGTCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACATGTACCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCTTGCCTCCTAAAAGCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAATTATGTAATGCAAAATTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + -,12$#),45+./221&0*0*#/,40,5/02502644))4155-.052,00)1//0.0#5/.03&-3(/3/334224/0-&/++),..)+%3.32*011+,-)'/1--.+&+/+0(.+,0/0+#%.-$''1-1.,0-0/0&1)-%./0/'&%#*'+),('(-).0%%.&,&/.'0++.,%)(&)11.1/,+%-),,,#/2//'&%++/%,11-00-,+--'-1.,1//&),2.--+',+*(%,$'.).,*(*,0-/.)*1.1-,-/./-/&10-&+(,-/-+/-.'10,+-+&11,-/0+/*,%(++0.10/-$0),,..+1110,111-1..-*11010,/-1,*-,200111*01*111...0,/(/1210---0.11.1011220,.,)+.(//.-+#$0.1*.*,,%./1+11.,0+200*0/,(1-+,-2100-0-11,.1.11-,000)0.100,/01010+(++&+,/+0--0+++.+%2--*-*,)%0/0//1--,,,'*+.+*1.*-000-/10,,+(&'00%+,+//,)1,,(,&10,..01-),,#*.-221+-/0+/'-021.-0,-+,0.-1*11*/01,.--11)-*./,*0/0,/-/110/&./&02-*00&20//%*2/11010/'0112/././)/$..12.).+/1..11-//+01...111....+/2/*+1+1.1*0,00,01(1,.010.11*+&1,0.,+001-11.0/.1+01111-01,.,0-+..10.+..20+-/,0.-'0.-,0/+(+*,-/+,/-//0)1010-1,0.,0/01-*%01/0&+.-1./&020$,0/,/'*',*0++&/.-1200++(/,*,2-/'-+$.-/,0200.2-,*1-200.0,//%*10/,.)'#(/*1-,.-1--110,*0-00-21121111(.010-12,,-/00.(00..%(,'0-.111,,01,)+*,0-/.2,11110*,*010,**+--(/*1*%%010+-/$/2001.011,)(&,2-110,012/-++&+,*1101.%/201002-)-/)(,..-0.01.12./%/,1211111)-),,1000,0'-11,10,-,/110/*(-2012.0-21-,*)'-+-)+&0--),.)124303.3*/,-/.4/4-35646660.536-41344/.4432560411(6/1+510/*504314/35,5656362560-63664665406.4-100210-41104)51*/5+522545+10-3)33'1554622-1+565231540,655)2660006655631+555444$)455-'052,-+4544443-#-031114./4/20.1%+154,//1.232-+.16361641/24415104.2162'545410/1301&06-23/4.56121133(2)-24+/26524)0*1.23.0*35.//.0/11/&614/52211532552./+05026654512315533'32014'0.44'.2-1530.2#)1240.03*02333.2/3.10.*33166/51/6033210-*+(.0.//0/)341'.2/0,+045211+5511)/402/5%/012136/&1*,03&24543&64+02/0+306.6000045563*,213(.0//$-/31*//(.320565405*40345443##(.121)-.2+.0)311+-1*154/+-%31500432+2.3+014+166105546-/1006200/-*.51-)6+40*,-/264664156/2555612.625621355(54522./.() @rCer/3/2341_60_CCS ATGGGGACTGCAGCACTAGCCGTCTGCAGCTCCGGCCGCCACTCGCGCCTCTCCAGCCTCTGCAGGCCCAAACGCCACCAGCACCATGGCCAGCACCATTTCGGCTTACAAGGAGAAGATGAAGGAGCTGTCGGTGCTGTCACTCATCTGCTCCTGCTTCTACACACAGCCGCACCCCAACACCATCTACCAGTATGGGGACATGGAGGTGAAGCAGCTGGACAAGCGGGCCTCTGGCCAGAGCTTCGAGGTCATCCTCAAGTCCCCTTCTGACCTGTCCCCAGAGAGCCCTATGCTCTCCTCTCCACCCAAGAAGAAGGACACCTCCCTGGAGGAGCTGCAAAAGCGGCTGGAGGCAGCTGAGGAGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACAACAACTTCAGCCGGCAGGCGGAGGAGAAGCTCAACTACAAGATGGAGCTCAGCAAGGAGATCCGCGAGGCGCACCTGGCCGCACTGCGCGAGCGGCTGCGCGAGAAGGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGGAGATGTCGGGCTAAGGGCCCGGGACGGGCGGCGCCCATCCTGCGACAGAACACGTTCGGGTTTCGGTTTTGTTTCGTTCACTCTCTGTCTAGAGAATCAAAAAAAATGCAACTTTTGTTCCTCCTCCCCCACCCACGCCCCAGCTTCATGCTTCTCTTCTGCACTCAGCCGCCCCGCCCTGTCCTCGTGGTGAGTCGCTGACCACGGCTTCCCCTGCAGGAGCCGCCGGGCGTGAGACGCGGTCCCTCGGTGCAGACACCAGGCCGGGCGAGGCTGGGTCCCCCGGGGGCCTTGTGAGAGAGGTGGTGGTGACCGTGGTAACCACAGGGCGGTGGCGTGGGATCGCGGGTCCTTACACTGGGCTGTCTGGTCAGCATGTGCAGGTCAGGGCAGGTCCTCTGAGCCGGCGCCCCTGGCCAACAGGCGAGGCTAGGGTACCTGCTGTCTTTCCAAGGGGAAGGGGCTCCCCATGCGGGAGGGGCAACGGGGGAGGGGGGGGGTGATGGTGCCTGGGAGCCTGCGTGTTAAGCGGGAGCTTGTTTGAACTGGCAGGCAGGTGGGTGGGGGCTGCAGCTCTCCTTAATGTGGTTGCACAGGGGTCCTCTGAGACCACCTGGCCTGAGGTGGACACCCTGGGCCTTCCTGGAAGCCTGCAGTTGGCGGCCTGCCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCCAGGGGCCCATGAGCAGGCTGCCGTGGTCTAGAGGTTGTGGGCAGCATGGACAGTCCCCCACTCAGCAGTGCAAGAGTTCCAAAGAGCCTCTGGCCCAGGCGCCTCGGTGAGACAGCCCCGCCGCCCTCCCCACCAGGGCTTTGCGGATGTCCTTGAAAGACCCGGCCTAGAGCCCTTTGGAGTGCTGGCCCCTCCTGTGCCCTCTGCCCTGGTGGAAGTGGCAGCCACAAGTCCTCCTCAGGGAGCCCTGAGGGGGATTTTGTGGGACTGCTGCCCACAGATCCAGGGTTGGAAGGGCAGCGGGTAAGGTTCACAAGCCACCCCCACACCCTTCCCACTCGGCACCCAGAGGGGCTGTGGGTCGAGGCCTGACTCCAGGCCTCTCCTGCCCACACCTTCTGGGCTGGGTTCCTTCTCTCCCTTGGATGCCCAGTGCTGGCCTTGGAGGACGGTCATCTGGAGGACGGGGGTGGGGGAGGCTGTCTTTGTACCACTGCAGCATCCCCCACTTCCCCACAGAAGCCCCATCCCAAAGCTGCTGCCTGGCCCATTGCTGTAAAATGTGAAGGGGGCAGCTGAGTTCTCTTAGGACCCAGAGCCAGGGCCCTCAGCTTCCATCCTGCGGGAGGCCTTGGGCAGGCACTGCCAGCGTCTTCCAGGGCCACACCAGGGACTATGGGAGGATCCTGACCCCTGCAGGGCTCAGGGGTCAGCAGGGACCCACTGCCCCGTCTCCCTCTCCCCACCGAGACAGCCCCAGAGGGAGCAGCCAGCTGGGATGGGAACCCAAGGCTGCCCACATGTGGCTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGGCTGGGATTCTCCTCACGGTGGCAGCTCTCATAGCGAAAGCCTAGTGTAATATGCACCCATCTCATCCACGTAGTAAAGTGAACTTAAAAATTAAATCAAATGAACAATAAACACCTGTGTGTTT + =>??<8685>7*29;99>=78::3176;29<:8;839;677>?<>?4<>0==3<0=4:<57705=72/=<72;=455268?9>900914:;2=5?;@40<77;;:888:8>>A==>7<<5?4;,9@9<<>??@>B==<8<4:<598=6;98=BA:<3=7<<=?AA>A=3/&?8?9<-<@;@>;?A2<47??=ABB;=>87:85>=AB9A@A=75A;?:?A;4A6<;<5>;?CC;@?>=?@A57@@@A754<7>>?=>9@;4;=<::1-=8=1-<:?2<3<;<@C8?7;>4B:,=B9@?=;=55>?;:48==0==B226C>=?+@<9563326:?A0<9:0/=A;@8;89*2462948:;/3'4;:;>8<-486:7@<7/<.9:921,2'21;=586=56:7<6=67<2><<:;(?=3=;<9.8<8<9<7?A8=<==>>>=;=>>>3':57::/3/<35-67864;8;@=:)<;9749<58;5.57<563725<<39=7B@>6:A3@@4>?;9;7?2==5;5C=7B8;85>B<779B?6;<;8;299-1;8(;B>494'4:=4=5.(1*##)%)(*...'&('*#%')(*,,,%#,37:3:75.$/53741773.471*1+2).$//.3&7;8CAA76A;>;@>2;066B>7<<8<:93;;>8+87:4>B47->5876/5-85;?9@>@/56@B@?;:821<7=.65*70::4?3/6.<=;0:<=9A9-6077>469=7A2<:+9-:9909/>;<=4833+6129265;926>496<:>9/6>3>5:=@<78;9??4;702;06;=7;+=7-1)088<99:9AA:=7>9,>8@:;7C<<307=:358;885713;8;%67;99C9:;849376@<:>:0,+43%;=A661--/*&2*058075=<=75B=3A@;==07@C@88//26,3;84=B<;8<59*<3429A;8,:3<98568:040.73+1;?6=@=<8;==A?@>7:6:17%28183:98.,;;>B96:64=03?-&9276595;79@;::978257?8A5A7<4=759:=?=2=;3;;1,1286003312(2?A>;:4=69-67/036>:1663'/7963:473/;'298@9@C:=7>73=818/3,+*2013$.544<>?<6<>2135%4+>42410*881911,+<8;7CACA5@;7:+8<8=8=<4704>=;<;739-;BA:@<=7:<7=B?A?=)060:*8;4-:?;===,:7=8<;89>9=*+6717-;=2;9:598BA:?.=8:=8<<84=<.<5:19:;?A7>C6.:94?1;;><28743+8@4:<87ABB:;=:<@;>?=CCCC0;?>9/>;88/6@8:7<@=:5:8,;8<=/@CA:A>B8@:;?246>=89(;80>8A;:B?>8>2A=392.>9487<76:;:<::&)=?A6?3;A=;=7>36BCC>C>;@>=;CA;?2<<770;8:@9A3<:=:+949=3@?C::6747.;=1=76.,>>>:.4=B85%8?<95;<>;?-5?@A0A:>B.9*4>8@C637:8=B@@B?>5?<7:;4>?AA2>7?@<<=@?2@>><.;;?A>A?;6AAB=>A?9?@0;;6;5>:C@C=A7=;:;<21>1=,68><5;?>*@;B::8-:=>953-&;,:A?.@:;<=?86:B69:/7=@@/>A4>5<3<==?=?<+=;<=><>348=:9/6B?>6??>*/7046>29<9<0=<:243-.%1+09/689@>A?<4:7=958.,:=*<864<=867<=CC99:;>/C=>@8>7=78/<>97782)4;?7497%154:*5=>?;75:.48.?91536416;4-35(<>:4+3:5921,+,24+27<5<9680696031,<98:/45.6,1.-00-23542296202385798/;;61.66:507360.0=:;=8-*5%05.<;68)9>78233613-3275=<:75276. @rCer/5/2043_56_CCS ATGGGTAGACTGGGTCAAAGCTTATTTAAGTATATGGACAGAGCTGCAGGCTTACATTAAGGAGTTCCATACCACCGGACTGGCCTGGAGCAAAACGGGGCCTGTGGCAAAGAACTGAGTGGACTGCCATCTGGACCCTCTGCTGGATCAGGTCCTCCTCCCCCTCCGCCAGGCCCCCCTCCTCCCCCAGTCTCTACCAGTTCAGGCTCAGATGAGTCCGCTTCCCGCTCAGCACTGTTTGCGCAAATTAATCAGGGGAGAGCATCACACATGCCCTGAAGCACGTATCTGATGACATGAAGACTCACAAGAACCCTGCCCTGAAGGCTCAGAGTGGTCCAGTACGCAGTGGCCCCAAGCCATTCTCTGCACCTAAACCCCAAACCAGCCCGTCCCCCAAACCAGCCACAAAGAAGGAGCCAGCTGTACTTGAACTGGAGGGCAAGAAATGGAGAGTGGAAAATCAGGAAAATGTTTCCAACCTGGTGATTGATGACACAGAGCTGAAACAGGTGGCTTACATATACAAGTGTGTCAACACGACATTGCAAATCAAGGGCAAAATTAACTCCATTACAGTAGATAACTGTAAGAAACTTGGTCTGGTATTCGATGACGTGGTGGCATTGTGGAGATAATCAACAGTAGGGATGTCAAAGTTCAGGTAATGGGTAAAGTGCCAACCATATCCATCAACAAAACAGATGGCTGCCATGCTTACCTGAGCAAGAATTCCCTGGATTGTGAAATAGTCAGTGCCAAATCTTCCGAGATGAATGTCCTCATTCCTACAGAAGGCGGTGACTTTAATGAATTCCCAGTTCCTGAGCAGTTCAAGACCCTCTGGAATGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAAGCGAAGTGCCACTGGGTTCTTTGCCCTCCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTTCTAGATTTCCTCTACCTTTCTGCTCTTAAAACTGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTGGGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGACTGATGATGCATTTTAGCTTTGAGCTTTTGGGGGTTATTCTACCAACAAACAAACAGTCCATTGGAAAGAAAACAGTCCCAGGAATTAACAGATCAGAATGTTCACACTGGTTAATCTTTTTCTAACAGTGAGCATGAAGGTAGCAGAAGCTGGTGTGTTTCCAGATGGTTCTTCTAACCAAACTAATTTTCACTGTTGACAAGTGAGGCAAGGGTTGCACTGGACCGAAGGCTGAGGCTTGGCCATCTAGCATTCCATGCAGAATGGTTTCCCATAAGCATTCCTTTTATTCTCTGTTCTATCCTGGGTCTGCCTCAACCATGAGATAGGAGAGTCTCCGGTACTAGCTGCTATCCAGGGCAGTTAATGGAGTCTTGAACCCTTTCTTTCTCTGGGATCCCTGACTAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAGGAAAAACAACACACCATTTCAAGGAGTCTGGCATTCCTGAATCCTCCTTCCCTGCTAGGTGCCTGTCACCTGTCTTCACTGCCTGCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCCAAGCACCTGAACAGAGGACTAAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGATTTATGTAAGAATCTTGCACAGCACTGCTAATGTAAATTTCAGTTTTTCCCCTCTAGGACAAACACTTACCAAAATATGCAACTTTTTTTTGGTGGGAAGAGAGATTGTCCTGTGATTTCTACCCATTTCCTGAGGCCTGTGGAAATAAACCTTTATGTACTTAAAGTTATACAGAAAATAGAATAAAGTTAATAC + DGEG*9BKJ?GGI/CHIJ+IJKEKKK4H>JFGIJFKCJHKFGJKCHKJKIKK?KKHFEKFK9GAJDFFIHGKEFJCHHHKFKCHIIHKIAJIJHIDGHFHFGCDF?KK?FI:KKK;I0>KGFJHDDIBHIEICHGH6KKF5HK;KHIGGD;GCDHKF9KJAAIJEHHHKG7HJGD4JHJEKJHIDFHIJDG:CHKFFIJJKIIIKKK@EFJFEKCDFHDKGDIEJIDAAEB@ACHK;JJIHJIJKIG8;%;H;GBG=GII4EHFG8G5JGFCCFJCIFIID;GHH8IHE>CJ:EAFFII.JJ=HHIBG?DA=:=DJHGIIJEFFBE7J6C9GEEF9B;>J@AF@EDG:IFBHHBE;IH?FHF=F9IIJG+>HHIEECEGF4GHAD@?C5F8EEDIG5GEGFHIGHFGI=G;GAFH>IHJFGHIGBHFHJEIGFFHF-;>JJ>FFGIIFCHH?FHBHAG>EGIHAEGDI@FC3D:GCF9FABD?EHBC9CH;DGB0G?GGD6C@E?EDDFCHGAJIGGHFEHGCHEHGI/I>C=IHHFGDGHE@FADFDJIHJGGF?F:CICCHFE@CGFC@8F9DI6EF?E>DBGDHG6AI=?GF=J@DHIEEIICJG:FHHI?;DC8:@IIHEEDA=GE;EDCF95=D5H3ECD@EA9?BE=AFFDG?9B8?B+D?DCA?DG:9E?FE85%79CFGC@@?CDFEE7F@ECA>EGCECF?@=C;>D@CDFBD@F?B@?F6A;>C:AE>7E8AF>>C,CG@FEGC7DD97FBBE?E@A5@CB=FDBE?EADCC0AED/FDE?@AC@BDEC:?@)5.>C?=*<;965=3:0?>D5BE7BBECECAF?EADAE@ECG;EB9@A?F;GGCEECCBG=CCB+@EC;ACBC?@?E>EDF@AFEAE;BGA?DC4AFB>EF?:FDE;5>EEE@AD@FEFE@AFFF8EAGEADEC>GFEG?B>A8FDFGCCEE?CFC@D7;AEE<7CCB&BE>AE4?>B@=?A6GCDA?GFE=>9<>EF;?BFFDFE>)65>=G9A7>DC@ABE@?EF>@ADB1>6>BD1CCE6ABFA2E=@:;>C?9EGB@BE4E?F>3AB@DFEE4ED9D;>DCAEGCC;@3BA:FE9FE-?E8FA;58 @rCer/6/24_1545_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGTTTAACTGTCTCTTACTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTT + @B%AEF2E1=EB47CGE=6DAJDFJB@9FGADC4HH4G2>GGC9EDD;A?B5@;C207H>1HFHBI/FJEHFEGF7CCGH7DG?HJ:J==B?.=AC:@@G6C/BFHICJ+IFIGH8G4H.GHHEDD7'@BCJ?IFFI4GFEC7GF8I<@EFGD?EEB4F5(CFECDFBEEFHDGHH:J;@?G=EF;G9BAHKJJAKGEKFFHEDKII@IBKKEFK?JKJKK>7K?J3KJG@KE:JJKJKFKGA&KC@JJFD@I;GAKCCJI=KIJII>;>KAIH>JIGEJFK:JGH63I5I;KJDJJIKKGJD?I>?EICKKJI;KJIKEJECEDEJGJHJ:IIIKJJJJGKJJGBKI5HEIEHEJJIKJKKEJGJKFKJHDKJCHJFJ8;KHIJA:HJ;JJJIKCKHG0BKKJJ?KKK@KHHKKKG%G;HIJJIKJFJH2JGIBKHJ;CKHFCIDKJGKKHAEIF3JHAEFKKHKII;GEHJIFJGAKKHJCJDI6KCKJKGFJ5GIK8AJ;HFJJK/JHEJHHKKJ'JCKEKKFKBK-KJIHHKJFEKKJ?KFK,GH;GF9JKDGJ5H8(KJCFIFC'JI=JK7KKKIGJBJI-KFGKGJHH;KJJ@G>HDIHIF9'G.EF?KIEEE1:ACKHJ(JFEIDIKJAHHJKGKJFHFJKIKKJIKGKIJ?JE;IHG0D2CHIIFADJEFHKKGIGKKDFIGJHII?KKDKIKHK3J>K>IHKKGJ,KKKKKKIJHJ:KKHKKIKEKG?J7JH@KJI>IKKBKJKJJHJJCCI5KKIK+AJKEI@K:JGDAEH?JKKGKJKJ6IDKC9IKKCIJ@KI>IFAGGJAIJIBDJIFHGKDHGIJIFGBEEFFE?FFJHKDJGKKKKJCH(JGKHKJADKJB?EHJJJKAGJJ&GJHIKIKIFJ*K=JHKJHKI>JJJHJCJICEGGKKGH?:G7KIKKFKHJKJKKJJHK@KJKKKIJDJFKJFJ;HGKKKDGKHHKJDIKIKKBKHJ>EFEB>GKIAIDG4KKKK7KKKA0KKHIJJKJKIHEGEJJH+J@FJJGKJIJBIAH6G;KG @rCer/7/24_1655_CCS ATGGGAGTTGGAGTCGTTGCTGCGCGGAGGGAATGAATGGGCGCTGGGAACACGCCCGCGAGTGGGGACGCGCCGGCCGTAGCGAGGGCCTTAGCGTGTGATGGCGGGGTCTGGTCGCTTCCCCGCAGCATGGAGGACGATGCACCAGTGATCTACGGGCTGGAGTTCCAGGCACGTGCTTTAACACTCAAACTGCAGAAAACAGATGCCATCGGTTTTTGGTTGGGACACAGTCTCTTAAATATGATAATCAGATCCACATCATAGATTTTGATGATGAAAACAACATTATAAATAAAATGTCCTCCTCCATCAAGCGGGTGAAATCTGGCACATTAGCGCTAGCCCGCAGACAGAGGCGTGCTGGCGACCTGCTACAACAGAACTTCAGACAGCAAAGTCCTGACATGTGCAGCCGTGTGGAGGATGCCGAAGGAATTGGAATCAGGCAGCCACGAGTCCCCCGATGATTCATCCAGCACGGCGCAGACCCTGGAGCTGCTCTGTCACCTTGACAACACAGCCCACAGCAACATGGCCTGTGTCGTGTGGGAGCCAATGGGAGATGGGAAGAAAATCATTTCATTGGCCGATACCATACCTGCTGTGGGATTTACAGGAAAGCTCAAGCCAGGCTGTGCTGGCCAGCTCAGCCTCCCTGGGAGGGAAGGGACAACTGAGTTCACCTCGGGCGTGGAGTCCGCATCACAACTGCACCCAGGTGGCCACAGCGAACGACACCACCCTCCGTGGCTGGGACACCCGGAGCATGAGCCAGATCTATTGCATAGAGAATGCCCACGGACAGCTGGTGCGGGATCTTGACTTCAATCCCAACAAGCAGTACTACTTGGCCAGCTGCGGAGACGACTGTAGGTGAAGTTCTGGGACACCCGAAACGTCACCGAACCCGTGAAGACCCTGGAGGAGCACTCCCACTGGGTGTGGAACGTCCGTTACAACCACTCTCACGACCAGCTGGTCCTCACTGGCAGCAGTGACAGCAGAGTCATCCTTTCCAACATGGTGTCCATCTCGTCGGAGCCCTTCGGCCACTTGGTAGACGACGATGACATCAGTGACCAGGAAGACCACCGTTCCGAGGAGAAGAGCAAGGAGCCCTGCAGGACAACGTCATCGCCACCTACGAGGAGCACGAGGACAGCGTCTACGCTGTGGGACTGGTCCTCGGCGACCCGTGGCTGTTTGCCTCCCTGAGCTATGACGGGAGGCTCGTGATCAACAGGGTGCCCAGGCCCTGAAGTACCACATCCTGCTGTGACTCCCGGCCTGAGTTATCCAGGTTCCACTGGGTGGTTATGCTCTTGGCAGGTTCCCAAACAGTCACAGCTCTTTGGCGGTGACTCATTTTCCAGGTGCTCCCTCTCTGGAGAGCGCTGTCCCCTTCCTCTAGCAGCAGCGTTTATGAATGGGGTGAATGGAGCTGTTGTCGACGGCACGCTGACGCCTGAACCCAGCCGCTGTCGGCAGAGACGGAGCCCCACATTGTTATGTGAATAACAACATTTTCTGTTTTAAGGGTGTTAGGAGTTCCACTTTAAAAAATGTTCCTGCAATAGTAACTCTTCTTTCTCTTCAGAGTAACAATGAAATAAATAAATCCACGCTGC + -&%+($'#(%&+,,('$,(*,'*-)(,%%(++(--(-+(---,))(*+(+'$%&$%*--,(#''***(+---+*(,(,-),,),+(,,''(+$((%%*,(,&'.*(-+*-/-.2/1/,//%,-.---*,0,/20&0,1,/(,,-,+.*,.'-1+-.'+),$*./.&-,.1,*',.)**1/20%*..'-0-01.-,/+,)+-*,/.),/12/$(),)111.02+.+10,,+'.1/-/0&,$+))+*)-+,+&*(*'%$)))'+,/.010)0/.%(+/-11+0./.%,-)(*&***+(&.00/11*0,*-,/,1(.,1*0-0-/.)0/*.,-0,//)+10--(')%($'(%./00,(-+(+,+*++''*(*+*))*('%)'((((%'"&'**(*,-+,,.0/&,0-,*,-+-,-/--,,*%$*')&&145,0542.-4(-//,1#'-*24.3(.,20-2021%/0/-,*034+-),0,2,,*&-15212-2'&.153-0//0*+/.)+.105536/-.(/./2+.*203455,%.%*-,4/3)552424124-3343*5)54161*1/2.3646/&00.1/4*5552)5)1*155.&25452#+/255651665.664322105625./*3206.15.'.43,(+/06,5-3623564162,-661*53,4/66'+%--30$&).2'-./5&31#$/..3441254/4301(/15440-554&01/604+02005+224444+2.-42,02511633-54213//556563.32141242/,/34%/4,214./04666.//51(,*14,32,/352+55564+5550164+55164262012.1415.04/2636/3422555)5/3*35/4+54$-152)2*01)2&03*+*%423126//41023-(+)324.)050/466/.2233+31*-)-06225.6212-,643265.6504.311-3/024,202/456,04652/2212004462421240,-3503,,.322-116/4320-62.--0004+2.2324665%,-/066466.6&/,/2636550020+4*/4625-/23261/.3026)33./1,///,0%-2506,3+1./-4).-/2)&/0/443102513+/56366414404-406415)-+./.3-520+10/33/)30/-0/$33)/1161/651+&%,/53635/64.2*654-40*2053465204304(41()53/4./50)32540/00-.&11/%2*5564*1500*21314.4325265-422*5.*01256352652566150512-10)2/-56340,//./,416551220)66,65101135005545)52,4424164+001$/1,)/215030.-6645,4&$1144/)/0//.%243(//6544115246.,53#33.(015*(15451-3566624,2/44.,*2006530(5/135/364456+530516565631/3)+/)*2/+.)/*1532/,464.642(.0-3*(/2(11+)230301*/2,)4(///-%*-.0/4)3$)-(*23&/3303/4*0-2(-/+3434346311*350350/-21514+2.%5212/4242.#1.,.311/2,208/83 @rCer/10/0_1630_CCS CGTCGCAGGAGGAGCGCGCGGGCACCGGTGCCGCTGACCGAGCGTGCGAGGACTCCGAATTGGAGGCACGATGAAGACGCTGCTGCTGTTGTGGGGCTACTGCTGACCTGGGAGAGTGGCAGGTCCTGGGGGACCAGACAGTCTCGGCCAATGAGCTCCAGGAAAGTCTGATCAGGAAGTAAGTACCTCAATAAGGAAATTCAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAAGAAAGAGGATGCCCTAAATGAGACCAGGGATCAGAGACAAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCTGGTTGGCCGCCAGCTCGAGGTTCCTGAACCAGAGCTCACCCTTCTATTCTGGATAACGGCGACCGCATAGACTCCCTGCGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGAGCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTCCTTGAGATGATACATGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGTGGCTTCCCACACTTCGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCATCACTGTGACGGTCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGAGAAGTGAGATGTAAATGTGCTTTTGGACCTACGGGGCATCTGAGTCCAGCTCCCCGAGATGAGCTGCAGCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCAACTTCGCCCAGCCACTCCCTGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGTG + S5463&*1:-+85*56653%72'.0,(>975>=<>A=;>92*-<88:62;@/10)%#5>.?<>:*>.37<5)0'7<==66AA:9<>72(61=*;A@6>89@>@(===@5&:05@?==&>>:4=>?:2,??.:*7.'106=;1<:.?&A+>DF89=3>:>(B/8F.D.C@%8A*GHEAA=C6GBC>8576@C>@5&:==82?3CB?E8E2;5?@E>E@@BB,'>51,3,=7E:BH8B=>D6I::H-6:(0$C2=?967ED?7*GG=1JJF=1=6:C56D;**2E0F<@H,GGFH6IF;,'-5C+C'+DBAE3B7:+HI8=E?2DDHH53?'?5E<@EHGG>BF>IEE@F>:<6D5B9G407&=02:4A+@#CF/D>?BFA.1FF;+8*@++$3F@8B%$H/E6ECH54D4FB05B4@/7.4;8+A:@<@IGD441>9CG2=JB7JB?B?G79/I?IIE>B;H(0A;@H7@CG>@:9FFA;.H5G<;J8D31@7EG7IIB5G6)H,5&?A'%;0)&(=9.-?)5.<';?E9FIDGFFG6FCD,FCF?'E(EE56&DC+2(A-0CB$<7$A@,C9>'EFHF6BIF>EE>>:B=5E/C>:=?HDAF3E4G?8-E+%'75IDIB:GC58=BC8B8=E55I=D84AI?JFF9??<&=0JA2HEGEA*5ACD=I4JEBH,HG8/EHB:C;?F>7HGBHFIG:FJGF??E/CG>7:;1FI>@G>@GFICIF@-6;,D9FCFGE=51$G>@F5HEGG5?FIHD;CAIH=G*?HF9I%@ID5H>>BI2:?BFAH<5B9>3II9=?F7E1J?;=5=*B2)F25DF6HAD/D1F0C4G8I1..7?>5G,1B:+FB?688=:5D@9@6?DHC;5D>IAB=@B>3G)F;2J8IJ43DC6FDG:=J)2:>%B==J=+F;?-IIHEIG:HH;,E*J8BHJHI+EDEB3A-C3(G/B5CE>@9H@7DC,JF/5%;E(IFF4G;AE5FI4IEFE@ADBE@?9:B8:4&:&A@BE;CF@0F)CCF2:7G6&A;3/%GBG=HH)@BAEDB=/@D4D7IG1>)=>>D*07B6?A;58<<*F1:@8B<@9CIA9HH0DHFD;B0:EBID7&@:I>;HF+FGIH:GE<%@>>?@7?EF:8AF @rCer/11/487_52_CCS TGATGCCACACACAGTCAAAGCTGAACTAATACTTCACAATTGCATGCCAAATACATTTGATCAACAGGAACAAGTACCCTAGAGAGATATACCGCGCAAATTCTATTCATTAGAGATCCATCCCAAAATCTTACGACCTCCGATGTATGGATCAGGATCGATCCTAATGGTGCAGCATGCTTATCAGGCTGGGTGTCGTTTGTCTCACACGATTTAAAAAGTACTACGGTGATCTGAGTTTCAGCGCGTGAGCACATCCAGGCGGTTTTCTTATTCTAGTTGACTTTCTCCCTGTACGTAAAGGGACAAGAGTAAATTAAGCGCTTCCCACTTCACAAAGCGCCTTCCTATCATTAATAATGATCCTAGTCTTAATTTAGCATTAAATACCACACATTCCACCCGATAACAGGGTTTAAAAAAAAAAAAAACAT + #*&""*,+)%.)#,..,.&--."..+-&'+*-,.$&/.-#/$/#',#$+,#--,#..),/-.-+,#".(%'&&,.(.,+,--."+#*...+..,../--*-.%-,%,*-#"**-'*"'')*!!##%"$%")*$++-',++"-,....",.&///./*/".*'$-,--..-()/.*.,,##)"#'+($""""!+'+#**,-(,..#,--"-./+.)(,&.+,..&/"..%)-....$-"+$(+/*/+"*."%,&)'"(-',+%$!)$##&#+#&+")(#&#%''--+),+.+**(("&..#.#'.)#..--.%,""!--%-%.$-%#*#*$-..&-&,,(+-).*.&&--&%$//").-#+&(+.#--'&&&-(%%-+(+-.%&$#)+.*..+..*//,'.,-.+,//#,+..+*(,&).''('&)$**(*'++#$ @rCer/13/2403_78_CCS GACAGTTACCATGGCCGAAGACGCAGACACATGCGCCAATAGAGCTGGAGGAGATGCAGCGAAGTAGGGGTTCTGACCAGTTGGCTATTGAGTCGCCTGGAAGAGCACCCGTCGGTATGCATGCAAACTGGTTGAAGAGGACGGTAAAGATTGCTGGTATCAGAGATCTTTGGTTATGTTGGTATGAACAAGCGAGAACAAGACTGGAACGCATTGAGGAAGGGATGGACCAAATTCAATCAAGTACGATGAGAAAGAAGCATGAAAAGAATTTGACGGACCTAGGAAAATTCTGCGGCTTATTTGGTGTGTCCCTGTAACAAGCTTAAATTCAAGTTGGATGCTTACAAAAAAGCCTGGGGCAATAATCGGATGGGCAGTGCGGTGGCCAGCCAGCTCTGCTCGATGTAGTGACGAACGGGAGCAGATTGGCCATCTAGTGCGCGCGCTTCATCCGCAGGGGTAACAACATGATTGTCGAGAAAATGAAATGGATGAAAACCTGGAGCCACGGTGAAGCGGCGTCAGTCGGGAACCTCCTTGTCACATGGCCCTGAGATATGAGGCAATGAGATCGATACACAGAATCAGCGCAGATCGACAGGATCATGGAGAAGAGCATGATTCCAACCAAACCAGAATTTGATGAGGCACAACCAACGTGCAACACAAGATGCTAGGAATGGTTAAATGTGCCCACGCCGTGTTCTCCTCTGGCGAATGCTATCGGGCAAGATAGCTCCTTCATGCTTTTCTCATGGTATTATCTAGTAGGTCTGCCACACATAACACACATCAGTCCACCCCCATTGTGAATTGTCTTGTCCTTGTGTCATCTGTACAGCTTCCAACAAATACTTTTGTCTTTTGTCTCTCTGGGTCTCTTCTTTCCAAAAGGTTGTATATAGTGGTCTCATTGGGTATCTGTTGCTCTAACTCCTTGAGTCGTTGAGTTTCATTTTTCCTTTTCTCTCCTCGGTGGCATTTTGTCTGAATAACAACAAATTTAGGCAATGCTCAATGTTGCTTTGTTGATTCGTTCAATTCCACCCGCTTCCCTGTTCCTCTGTAAGTAAAACTGTGGATCATTCCACCAGAGCTAACGTGCGCAACACCAAGTCCTATTGATCCAAATGTCAAGGCTGAACTTGCCAATCTCTAGCAAAAAAATAGTTCGACCGTGCTTCGGTTCCTCTGGCTGTTATCTGTCCTTTAGTCGCATCCATCCCCAAGATTAGAACAAGATTGCTGGAATTACAATAAACAGCGTCGATATGCAGGAGGTAACCGAACGTCGCATGTGATTTATGACCAGTACAACATTCTACCTGGGCAATGGATGGAACCTAACACCCTGCAGACCATTGGTTACGATTCGCCCGCCTACTTAAACAAACAAGCGGTTTCCATGACGGGCATAGGCATAGCTGATGGACTAACAAGCTGCACGAACACACATCTACAAAATCAACAGCCCACAAAGAACCCAATACAACCCTCAGAACAGAAGTCAGAGCAGGGAAGGCCACACTGACCTCCAAGTATGAGAGACGTGTCAACGAAATTAAGTGCAAATCCAGGACAAGAATCGACCTCACAACTAAACCGAGCATGCAGGTGTGATCTACTTTATCAATCACTCTGCCAAAAATTTATGATTTAGGCCGACTTACCTTAAAATCCTATAATCATCCTTTTTTTTTTAAAAAATAAGAATTGGTTTATAAAAATATGCGAATTATGACCAACAGAACTCACCATTTAACTCCAACTTTTCCAGCACACAATATCCCATGTCTTGCTCGAACTTATTCCGTTAAGGATGGATGTAAGGAAATATATCGTTTGTGACTAATCTTCAGCAGTGGGCCCTACAGAATTCTCCTGGCAGAACCCAGTCGAATCAGTGTGCTGGTGCAACACCCGTGATCAGACCTCGGTAAAATAGATATCTATAAAGGCGGCATGAACTCGTTCTACTAAACCAACAACATTGTGCCCATCTGCTGTGTCCCTTGTTATACAGCCACAATTCTTGTGTGGCTCTATCGTTAGCATGGCCTACACCAAAGTTGCTAGAGCATGGTGTTAGTAGCTGATAAAAAACCCCTTATACTGACCACAATAATATAAAATGACAATGTCACAAAAAATATAATCCCAACTGCGTAGGATCCAAATAGTCTCACTGCTTATGAAGCAGGTGGTAATGATTTAAATATCCCCCTGTCCATTCTGTCAGTTTGTGTATAGTAGACCATTGAAATTTTGTCGCTGTTAATTATTATTATAAAAGAATTGTAAAAAAAAAAAAATAGAAACTAC + '##*-*&,((--&),,,.-..,/./'...".+(..+)--."..&-).)-%-../.&-#----&,$*)%&##&,(,,,#+-$$+',,&#*..#...$.-'--,"+/.).,,$...,.///.$//.))-,..&-#'*%,-&+../+-,+../.$/...*./////",.#..),/,/*-..-#.'--&..+-(+%&'.-.,.--")../+.(//../)./-(,-.+),//)/.-+,.#+,.).",+,#''#////!-,..-'('.#*.'(+&-,.)*..&.(,'*'#(*,%)&+),./-.).(%#-&)-+.....-,,.)/-./--///+/,/+&/+./-$.'.//./*/+.*+*+.',.'.#,(---.&-.'-(&&-$))$,"')*'--)*(',*,-+-(+-.---.#.)-),'%,,..+'.+&.,&,&-)(.)+-.&-"..(."+..#-./*.//../-)'"''---.*-#.*/.%*+--.%-.((.///+.+),),+***.//./+/.+.'#/*.$#.,..(.$.//".).+')%--.+.(#+*//.&//&,+,&..-//./-$.*.../..,%.///#.../,//-//"/-"--.//.///+/*.//-/-&-./-.%-.#*..()*),,#-'+-.-.+.-+%#,.&.,.)-(*-&--,.,..-.-./.()-//.(.--.).-./-(*/,./..-*-*/.#,(/..'*..,.(...*...-&/..-/-.,'.%.//...-++-(%/...--'(&-,)-'-$-'-)-..-..)--*--+*&+,),,$$-+(-(------'-++*+&#)*.-(-../-.$.,)-%.)(,-%./.-.*//./."././+*.,+,--+../,.%,,--.&,&.+,....*..,))....*..),-,,(*&(*-$+&+'+..../*--,+%'"!+'++'!'%,#&,.-..-.+--.)..-..",)-/.,),//*(*+&-..),,/').-.&./+&)'(.-&'$$*%(-.-$-).--..(&,*,,.)$.-./..-../+*$.-,#%%+"..&+-#&).--+&-(,(#$('$$&#&$+)$&%$%+"+'('..*+-//.--#'"-.,(-,-,$&,-)...+/$.'("+%%('%$(*-+))##%)&"%##)##,,,.*(-)-,$'#$'#-%$*,...-+*%&-%($'+,,&+,$#,)++,##&($,-'-',-,&--&.,-'((----,*)+%#*#&%+&-*)(#.+&$&(&..-$((&'',+$+$%()))&%#"#%+'+,&(+,++#("'$+$(&+*#""%%#&&)((&-+#-+(-$-,%'-((((*..*-,,*$(+('&$$'-+-'(-$$(+'&,%&,",".%--).)-)))(&",..(&(-&##$#''(,%#&&"'$"#(*,,,*)-&'+-*-----.%).),--..'(*""""#()##*&'&#*)+*'%#($$#(%)'%$"##'*#*(&*++++)""$&)%$+%,,+...*()..,),*+*($(,*(#-('($&#&%++*-,(((###&#)"%)##"*)#()$$"&-....+--+'----%"''*$'+#%'$')*,--(.-%.(-&%*'$%#)(+#$*()&!)$&$"&''##$#'(*"*%)+&+&#&&&+)##%&*&*)((#&#"$))(#,,-(+(,$##)+)())*$#--,&.,#),-#$&&)*#,*'-,%#(%,-,%#../-//./...%'%(%)(&+.)(()&",,-.,-#+$)$)+%-%&))"&%'#')&-%'%*-+('%,+&##+,((,+++%$,)(+#)''&*%$#'$#*()$'%%#)'+&###''))*##"'&&+(%,&-(&&$--'-$'$-*,&%"'%(#$#)%(*((#""%###$"))*,#(,*+%$%$#&$%"*$##'$+*$+''+#%'$%&(&&''##'&&+)&#)+&,-,*-$*&,*$(,+#'*++($%(**&$##&%##'#*%+,%&("###+*&))#'($)*"')$++-))*'&*"#"##)(*+'*,++',(&-,+$$'$&#)$&)$*&$($#'##$)$$'&&,'+*'$$#*+)+&-'$#)&$#+)+%'%&"%#%%###"%'%###)++))$)#$'***'*)*+-,+(*%'#)%$&$*)**#'%$$%&#$$###)#))$#'(%()----,,,&+#$*---&(*+*#++%%''&(%'"$#)%'$&**-+%&*#)"$)&%"#%#)*"$(((()*%&#&$*$#((%)&#$'#++)&"'#"()&'*('$#$#&$&&#&$#%++-,,)*-'(+'*$$"&&(#**$&,+&+%$%&$$%%$#'(%)+%%%#(**&$*&%#'###"($"##&"##$####$%%$'(*))##((&( @rCer/16/25_1478_CCS ATGGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACACTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGTCCCTATTGCAGGATCAATAGTTCTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTATCGCGACCTCTTCTCCTGATCCATATCACCATTATATCAACAGGACTTAACATACTATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACACGAGGAGCACTCACACTCACATAATCAACATAAACCCCCTTCACACGAGAAAACATTAATATTCATACACTCGCTCCATTATCCTTCTATCTCTCAACCCAACATCATCCTGGGATTTACTTCC + 25#959&8''2=8:A:?B@.@AA+;A;DF;>FDC'CDB,D9@@9B;BBB7F;DFBI>G;@D6=>:C??I:(HECFA=I9GC(C;IIFG4D8AFA/:(:=CH>J?>I;HIC8FE;C8JJKBK<5F7GBC?:HEDDIHE;FBEF(E4I<:FDJH7*@?IGBIII>80?>+AB8G7E+F=/G9GCBFK9JAJJIKIJ3JFJHG>G+J;GCA=HABB>I=BI@=8HIFF;-C;+BC4)A>E@AE9:?61H/3?GJ6JFBI>H8=@+:8<1=2DD>DF9IF34F4D?D80BBA;??CIDHB?;C312C(68+/(?C9F;1DCBC*FEE,GFCHDAD9HGB>?A;;IAHHIC<*CD?:AACC=-9269;A;GD936<7.GHHJ>=1A>3@@;07'A:E?13<*CDBDAGB:G(@A8IDA0==?@F?FF=G@C,CH?F/CDGDEED;DEIFD@CD4;11B=8FHCB9FBBE8HE@D@,F7B?4B?@D<;9+E;:,$B9@@H5G+B0F@E*E/G?EH1HB4GEH2=42GB@ECH:EEECEGEIH=B:<@&3A5FGG???4BDC;07@G?F9>G98B:@<2+@@=BC54%DFE?C>HG2$A=BHA=8C9@@H?59?<7=4FI4GCBGFGGGH>9+A)B@4FG99@/8B9A.@B1IG@;EF=J5BE)GHFE@D7HHG(GF;:F@IABD&BDD-EJDFCEIJ@79I9B<5@/:&@DDBA;G==DDGEG/?<@EJ=9<6A=EFGD6DGCH@7CCEE==8+.26.5-256.3.'0-.01,69010,4,.*/-5-5884.<40335780662790./*0712517915+608/&0+3,95-161''828;8725/+..5/9/0985559=76597)48;5#2792<76=18(/58/6.89=2;4(%,(%&1,(3+3&28%7037;1,6?)8462436#28=93;'67*3.-'6.:;10::;0112:6+2951.1742$0;:2;7562,)033)+%3893<5840*8,27(51#269:39136:85,3':7/)&&'&/'&'60+4815'0897>87%27.0.6-202.6489>:(+':90<0/<01%-3-8?=513833/106 @rCer/18/26_2169_CCS ATTGGGAGACCACCAAGAAGACGTGCAGCCACTCTCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCATTGGGCGCTTCTTTGGCGGTGACCAGGGGTGTGCCCAAGCGGGGCTCTGCAAGGACTCACACACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCTCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCCAGGATTTGCTACGGAGGCAGAGCGTCCGACTATAATCGGCTCACAAGGGATTCAAGGAGTCGATGGCCCAGGGCACGCTTTCCGAATTTTAAGCTGGAGGAAGAGATAGTCGCTCCGGATCACCCATGGCTAGACGCTGAAAACCCACCTGTTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGTCACATTTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACTACCCTCCACCCTTGACTTTCTTTCGCCGTGACGGTGACACCCTGCGCTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGAACAGTCAAGGAGTGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAAGCCCACAGCCGGAGAGTCCAGGAAGAACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCCAGCCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCCACCTTTGATTTTAGCGGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCATCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATAGTGGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAAGTGTACACTTGTTCCTGAAATTGAAATAAAACAAAACTTTTAAT + '$%#(('$'%&&"''($()(%&$$'$&($&,'$)%')*,'%')(+(*(((,+--.---%,-*'(-+-,,%+,&&-+%*-.,-(*.,())$'&(''&(--*++*%,)()&(,-)*',,.,()+))')'%,('*$'%())-*&,,(,*+(***--)--+'****%,)-*(%&'$$)()'(((,(&++(*,)*,&'$$%#'%$(+++,()$,*&++-(------+#*%''*++&%*+'#%&*-*-,$,+',&*$'##%()),(),(&'--*$(*&&)----),-+)-,,&-)&&'),,(),%+++&*),*-&(*(+.,),)-)++'*(+.--+,-,(*,()+*------+*,*.-*,#)*-+%)('*)',,(%#&&+,-,&$$'''(----(+,-+%##"""##'+&%*)&(*-,),(--$&#%,)(+-*$#%',%.-),()%(),'(',-*,'-)$&&,(+*,))*)+(-*(,,-)*#'$'''()*$&),,,'*+&(*,(+**+,!#$&+,,&,,-'$*)'-+-(((+$+---,%($"#*%)+('+-+,)-,+)+(&*(,%$&$'%(-))-*""$&'),.%&&+()-,$-&()*--.+-.,-*)*)$---)-,--.-)+&,)-+'+('#))'$++)%(.-(*$%(%+',+--+-++,)$+&'&$*-+,.)*&-,(*%+('-*--,*---'((&$$()'+,%)(&%%$#'*'(&,,')*,.-),(*)*)*.,,(+*,-,.-,-$'&,+-()''*%*('*&#(***(,+-)%*'')+&(+-)-)-,,,*,-,.+)*),,$++(++.)(*(('('-,'%$$+++++((-,*+,-&),.,--)*+%*+--+-+&$,-+,&*$)&,,,,,(+-&,---+(%%"#$))(-+)-+,,#*-*.-(#****+.--,,"$*---,'',,$&#,+$,,*(++..---,+-*,-(*''))'++,')-*)*,-,$&(')*&--+-),,,-)-,%,--,)-,(*&')&*--+()%(%()--.*-((#+)(&&')**)(&&'*,(,*)*((''##)*+%"%+--,'%(',,,&*+,+(-+%*(++-)+.,,(),)%+,(-'*(&'#%$$)--**-,+&+..+)(&)+),.+'+(+--+'#)*&,)&,(+--,-&((&*(+)'&''-(-(*)#'$#((*,'*,-*)+'*''+*(+,)#+''%*-)++$+.,--,.--+&**$*%')-&*&,---+.-)--(*-+*(,*--+*-*,('(--,))(')+),-++)'+))&$(((**'+-)-&&,)*((,-,(--,$+&$#'**+-*-(#'+,,-.,&*-)*+--+++(*,-,)*),()&(),&&&'-,'(*+&''(),-,,)+(,(+++,%)(+()+,,),),,,'(+-).)'*()-,-$)*&)'+-*-,*%+-(+*,,(+))(.*+)&*+.,*&%,&#'&#,&+-,,-),)*)))++-,+.-)+,.(,--*),(*,,(),'-((*$),)#('*--)-,-,)+%*+()**('##$%-)--,,,%%$)#*+)+&).-(&*'),),))%+*++,(,,.,),)**),,..+)*-,(**),,,,'*'+"%+(+--(-(&('#&%#$&(,&,,(()))&'',(,-----)(,*&'&(-*&,,(*(-,'"$)(,+'*&(('''*+-*)+--**)(*-.,)(*'+'-*$).*-*-,+$$$*(*(,,+.-,-)--).-+,-,'+,(,),&(&()(,+((()((((++'''%)-$(),,*((+*)--)(),,*,).-,-+$*%'%'($$'))&('+-+)(*'*&)$*))+,(&+,-(,&)'-+.-)*+#+*&&&'+-,(-,))&-*$"")++%&++),),(',,)*-*)&%&&$,)(--+$+,&,$(+(&''''(+++,(+'*)%)---*,,()+.)'--.-,*-,')(()(*,)**)-,,)+%''+,+(*-+-&--),(,(*-+,()))+),(('--,,*(+*.$%'-+&-,+&&,(**(,--)($&)(-,(-*#)*(&)*(,---,--*$,(&+-,(,,))-,-')&')),(-((*,+*)((')&%$$(#%##%%((%(''))%%%)))(&()&))(%(&%(()'&(#&'()%(((()'))&(#$%(&)$$#"$)&%((&)('%(%%%$$$)'$%&"$)% @rCer/20/1755_81_CCS TTATCCTCGCTCGGGACGCCGGCCGTCCTAAGCGGGGACGCCTGGGGGCGGCACTGGTGGCGTCTGTGTGGAGTGGGTGCCATTCGTAGCCTCGTCTGCCTCGAGTGGTCTTGGCGCGCCGTACCGCTCTCGGTGACCGGGTGAGGGAACCTCTGTGCGGAGGGGAACGCTCGCTGGCCCCCAAGCGCCCGCTCCTGGGGTTGTCGCCAGGGCGGCCTCCCGCCAGAGGATACCACTCGTTGTTGAGATGATGGAAATTGAGTCCTCGTATTTTCTCTCCGGGGCCCCCACCTCCCCTGCTCGTATGGTAGTGAGGAGAGAGTGTTGAGAGATTCACTGCCAGTAGCGCCTTTACAAGGTGAGAGTCTCGCGTGTCCTTCCCCAGCCACTGAATAACCAAAGACACATGGATTCCTATCAGAAGTGGCTTTGCCAAACCCAAATACTCCCCAACCGAGATCCATTTTGGAAAGCCCTTACCTCCAGTCCCCATCTTGAAGTTGGTCTGGCTCCTGGCTCTACGTTAGGGACTCGGCTTCTGTCTGCTTACCACTCCAGCGTGTGCTTGCTCGTGGCAGGACAACTGGATAATGCCACAGCTTAGCAACCCCTCTCCAATGCTCACCTTTGGCTCCTCTTGCGCCCTATCTCGCCCTTTGAAGGCCGGAGTGTGGCAGCAGCGAGGCAGCATGGCGAGCCAGTTGCGAGCCTGCGCAGAATCTTGTAGAGCATGGAGACTCTCTGACACTGTGGGATACCGGTGTGCATTGGGTATTCTTCCTAGCGCGCTGGTACTGTTCGTCAGAGGGGCCAGAGGTAGGGGAATGAGTTTTCTGATTGGTCAGGAGGTTCCGCGAGAGATTGGACAACGGTAGCACAGGATTATCCCTCCTGTAGTGAGTCCATTCTGCTTTGCCACCTGCGAAGTGGTGATTCTCTAGTTGGCACAGAAGCAGTCACACCATCTGACATGCTGCATGGCTGTCCCGGATTGCAGGGCGTTCACGACGTCTTGAATGGCTCGCTTGACTCTGGAGGTCTTGCGATGTACCAGAGTGCTCAGAATTATTTCCGAAAGAGTTGTTTGCCTTGGCGGATCTCACTGCGTGCGGAGCTCTCCGTCGCTCGCTATGCTCAGCGTCACCATAGGATCCTCAAATTCGGGATCATGGTCGCCACCCGAGTGTCGAGCGTGACACGCACACAAGGGACACCATGGGGCCACTAATGGCGCCTGCTTCTACGCTACGCCCTGGTGCGCACAGCGCGAAGTGGCAGTCTCCTTTGGTACGCGCCCAGGTATCCCAAGACGGCGCCGGCTCCAAGCTCGTCTCACACCGCAGCATCCCGGCGACGCGCGGCAGCGCCACAAATGAGGACACGCGGTCTCTTCTTAGGCCCTATTACAAGGGTATTCCTGTGACCTATGAGCCCGACAAGTTCTTCTGCTGGGCTCCGCTAACTGTATCTGCTAATGTGAACAGCTCCAGCAGCGCGCTGGAGCCCACCGCACACGCCCCCATCGTGCCTGGGCGCCTGCGGTTTTCTCACTCTCGCCCTGCAACTTCTGCTAACTCCTCGCCCGCGTTATAGAATACGTGTTGGAGAGAGGTGGAGAAACCCTCCCTGCTCTCACGCCCTCCTCACCAACAACAAACGTCTTTTTTCCTCTTT + -),.))&)+'(%$*'-.-+.-**--&*,$-,-,.)%'.'/*-.-)&((.#*,..+.),%&'%,#-,+,-.*)-'-)$,,$&-%+-.-+(**%,-,*,*(,+'+'&',%((+&'**+&,%),),&(+')**).+.--,--)("&,,)'+*'+*+,,%-,-)-+''%**-.--(-,-.*)*'%%-%.--'*+")'#(+)$(*'+,),,&)),($'-(&*+#)*+%$$+*)%*+'.,,..,+.(,+%,##%+%+(-",'-,#-,+,++,----,$(****,*,-(&#%(&&$'&)&$*(,----".+(--)$&(*+&,(-+-+-*-+-'..,-*%,'(---*'#,*'&*(+'*,%*..(+&+..,-..-....)//..-+'*$+)(//'--.++.,#.-&+%&-."(-..#.$..%,-#--///++//.*&'()%*%(*-,(&.,,....+,)%)+.-,/#-/)-/.%%&.)-*).&,-.*//..,-/.(*'(*,-&"*.'+.'"/,*/./,---.&)',-...--+$-*&#'')*-)+,#+'-,,#-$,'&,+&--&),-'*++$*&)'&*&*+),)'-.(,-*,.--+-++'-.),-)')&(#$%)'(%#&)*##)(&,,,(*('+(,&#-)(&()*+#)-+-'&(,,.)*%.&*++(*,'$-'&%+(&,----*.,.-'.+-,,)+#.,)--)+)%-*-,++#-++++',,-+-.*.-++,.$-,&,.,'"&.*"*(...&,..-.&.--'*%+*+,.-.)#++,)+,'-($,,.),.)-(%(-'/,/$//,*--./,*-/#.-+-&+)''"'.%,),,-%#$%+-*,,%&$&...-/).(#'(%*($&$*&-&*.%,#,-.(.(-%,--,-.-.),-+*),-$--''),(.----++-&'#(+)+&,$-,&,*.)+*..-)+,-,+*,*,+++&($(*+-&,-*+-+--,,..//.,.+.-+./(.--.-%+,"--.#.*$$..+($.),-#-+.&+*..,*//./....")&-."//,---/,/#.+.".,/+..+'/"+/#/+.#+,&,(/-+-,&.)..&-.)&"&#$#-%)).",-(%.'*-')(#,%-.&...----..,.-'(-(-,*)'((*-+(-')'+,&+--*-""(*-,%.-,&)-,)--,&'*+*+.(,-*'-*+-+(),*+*,-(*+-.)**#*,,+)+*',--,-)*+,+,&$#$+*..,...%+%&(&(+,&--)+)#,-.,,&,,+%,+,+,,"&('-*-,+-+-&+**)&*,+*+,(.---+)%(%(&,$,%+,*-)+#)%(#)-*+*,,,)..)%,(+.&(.,,++.-#,-,'**,+)(%&%+/-//-,&-&).+-.-/,/*,(/(.+*---+-&..-('-..-,,#'#..-)&,$',((-*."-#-,+%-*',."+,,-+',-$+,..-.((**,#(+#-,(-,)*-,,,,'(--*$,+*)"#,++..*-.('$%+,),&,,,-,,)(-,'(,)+)****#(+%(%,+'-,),*+.'+'#&(*%*&+$-,,+'()#$,))-'*')),)'*&($$&-'*+,--,+--$$+'$+(&()'%++-$&$+'+&$#+'(((..-,-..(.&,.-.,.*-.#,+/'--,,.,&-.+.-,--../),&&+,-"$.--..,--,+...-..(*&+,',...*+ @rCer/23/1597_61_CCS AACATGGGATGAGCAGTTCTCTAAAAACATAAAGCTTGGAATACATGAAGACTCACAAAATCGGAAGAGCTTCAGAGCTGTTAAGGTACTACACATCTGCCTGGCGATGAGATGGTTCTCTCAAGGATTACTGCACCAGAATGAAGGAAACCAGAAACATATCTATTATATCACAGGTGAGACCAAGGACCAGGTAGCTAACTCAGCCTTTGTGGAACGTCTTCGGAAACATGGCTTAGAAGTGATCTATATGATCGAGCCCATTGATGAGTACTGTGTCCAACAGCTAAAAGAATTTGAGGGGAAGACATTAGTGTCAGTCACCAAAGAGGGCTTGGAACTTCCAGAGGATGAAGAAGAGAAAAGAAACAGGAAGAGAAAAAACAAAGTTTGAGAACCTCTGCAAAATCATGAAAGACATACTGGAGAAAAAAGTTGAAAAGGTGGTTGTGTCAAACCGATTGGTGACGTCTCCATGCTGTATTGTCACAAGCACATATGGCTGGACAGCAAACATGGAGAATCATGAAAGCTCAAGCCCTAAGAGACAACTCAACAATGGGTTACATGGCAGCAAAGAAACACCTGGAGATAAACCCTGACCATTCCATTATTGAGACCTTAAGGCAAAAGGCAGAGGCTGATAAGAACGACAAGTCTGTGAAGGATCTGGTCATCTTGCTTTACGAAACTGCACTCCTGTCTTCTGGCTTCAGTCTGGAAGATCCCCAGACACATGCCAACAGGATCTACAGGATGATCAAACTTGGTCTGGGTATCGATGAAGATGATCCTACTGCTGATGATACCAGTGCAGCTGTAACTGAAGAAATGCCGCCCCTCGAAGGAGATGACGACACATCACGCATGGAAGAAGTAGACTAACCTCCGGCTGAGGATGACTTACCTGTTCAATACTCTACAATTCTTCTGATAATATATTTCCAGGATGTTTTTCTTTATTTTGTTAATATTAAAAGTCTGTATGGCATGACAACAACTACTTTAAGGGAAGATAAGATTTCTGTCTATTCTAAGTGATGCTGTGGTACCTTAGGCACTAAAGCAGAGCTAGTAATGCTTTTTTAGTTTCACATTGGTTTATTTTAACAGACTGGGGTAACGTGTGTTGTAAGATGTATGTAACATGATGTTAACTTGTGGTCTACAGTGTTTAGCTATCAAGCCGGATTTCTAAGTAGACCAAATCTTGTTATTGAAGTGTTCTCGAGCTATATATACCTGGATGTTTAGAAAGTATTGTTACATCTTGTAGGATCTACTTTTTGAACTTTTCATCCCCTGTAGTTGCCAATTTTGCATGTACTAGTCCTCTAGAAATAGGTTAAACTGAAGCAACTTGATAGAAGGAACTCTCCACAGGGCTTGTTTTCCAAAGAAAAGTATTGTTTGGAGGAGCAAAGTTATAAGCCTACCTAAGCATATCATAAAGCTGTTCAAAAATAACTCAAGTCTTGTGGATGGAAATGTAGTGCTGGAGTCACATTCTGCTTAAAGTTGTAACAAATACAGATG + C688,9;(990765:4B/=2;4:GD?-B7=;E2C:6&F9E99DE?7.K5=ED>EHJIFJ08IH,>5B$IGD$JGBIECFKK@I;D2CGH9EH?>AAF6B**(:=K:KKK&FIKKCKIIKDKKKKK1KDJKKKKFKGJJKDFKKIJHKKKKK1KK'KKKK.KCJKCK>IBJKKKKCKIKKK@K?KKKKKKKKKKJIJJKKD+K3KKIKKK1ICA@KKJ>K:ABK:KKKIKKKDKHK@KKB.D.KKKJKK:EAKKKIHKK;AKAKIDKKKJ=?KK.JKDKKK1KEKGDJK=KBIKKK/JKK$3>K(FKGKJJJKK1KK/KKJK9IKJKKKKKKKGKE?>KDK;KKKKJKKK8KKKJCKK:FGKKKK6KKIKIKEK/DKKJKJKKKK?GKIDK5KIKGEKCKKKJ:GIHKKCK@KKIFJK2DKEGK?>?KHIKIJ+=6K+K/K;EA?KJK$B2D?K@KI:K*K9F8K9IJGGFIBKAKIAFIFKK+KKJKHH.BKK3JK>KKJJKKFG;DCJKKBK;HGKKEKKJKIIJK8FGKKKEHKKKKKIJKKKEIKK(IEK@KKKK':JJK@JHJGHKKKJKKGJKKKJ@?:FKJK>K.FK/HKJEIAJKIK9DKFK;KKKJK'EKKJIKJJJGKKKJKK?EGJJJGKKKKKGJKKKGKKK3KKKHJ@JKJDGJKKKKK&IKKK=JKKJJ?K0KJ=>JKK,KK;KK3K@JKK=KK>EKKEKK@KKK2EKIKKHECFGJHKK=H>:FKKF=K$J(F>JHEKDHIJFK:KK3KJCKIKEKKK/FJJKKKKB @rCer/24/25_1646_CCS ATGGGATGCCCCAGTTAGACACATCGACATGGTTCACCCACTATTATGGCGATGCTTCCTACACTATATCTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCTTACAAAAAACCCTACCTTCAATCCCAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCCTACTCGTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCAACACCCTGCTTAGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGATCC + 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@rCer/26/0_1635_CCS GCGGCGATCCGAGCTGGGACTGGCTGCAGGCGGCGGGGTGCAGAGGACGCGGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGGTCTGCTGAGAACAGAGCCGGTCCCTGAGAAGGGAAGATGTGCTGCCACCATCAGTGCCACAGAGACCCTCTCAGAAGAGGAGCGGAAGAGCTAAGAAGAGAACTTGCAAAGGTAGAAGAAGAAATCCAGACTCTGTCTCAAGTGTTAGTAGCAAAGAGAAGCATCTAGCAGAGATCAAGCGGAAACTGGAATCAATTCTCTACAGGAACTAAAACAGAACATTGCCAAGGGTGGCAAGACGTGACAGCAACATCTGCTTACAAGAAGACATCTGAAACCTTGTCCCAGGCTGGACAGAAGGCCTCAGCTGCTTTTCGTCTGTTGGCTCAGTCATCACCAAAAAGCTGAAGACGTAAAAAACTCCCCAACTTTTAAATCATTTGAAGAAAGGTCGAAAACTTAAAGTCTAAAGTAGGGGAACCAAGCCTGCGGTGGTGATTTTGGAGAAGTCTTGAATTCGGCTGCAAATGCTAGTGCCACCACCACGGAGCCTCTTCCAGAACAGACACAGGAGAGCCTGTGAGATTCCTACCTTTGTTCTGCTACCCACTGCCAGATGCTGCAAGCGAGGTCCAAGCACATCTTGTCACATGCATTGCCATGAATTTCTACCAGATGTGCTTTATTTAGCTTTACATATTCCTTTGACCAAATAGTTTGTGGGTTAAACAAATGAAAATATCTTCAACTCTATTCCTGGAAACACCCTTTAGTGTACATTTATGTTCCTTTATTTAGGAAACACTGTTATAAAACACCTATAGTACCTGGGACATTCACTAGAATGATCTAAGAAGCTACAGATTGTCATAGTTGTTTTCCTACTTTACAAAATTGCTCCAGATCTGGAATGCCAGTTTGACCTTTGTCTTTATTTCCTTTTTTCCCCCTCTCTGAATCTCTGTATATTTGATTCTTAACTAAAATTGTTCTCTTAAATAATCTGAATCCTGGTAATTAAAAGTTGGGTATATTTTCTTTACCTCCAAGGGAAGAACTACCAGCTACAAAAAATATTTTGGAATAAGCACTGTTTTGGTATAAGGTACATATTTGGTTGAAGACACCAGACTGAAGTAAACAGCTGTGCATCCAATTTATTATAGTTTTGTAAGTAACAATATGTAATCAAACTTCCAGTGACTTGAGTGGAACTCCTACATCCTTATTTATCACCATTATGACAGTAAACATTTCAGTGTATTGTTTATTATACCACTTATATCAACTTATTTTCACCAGGTTAAAATTTTAATTCTACAAAATAGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAACTAGCCGGGCGATGTGGCGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGAAGCTTGCAGTGAGCTGAGATCCGGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCGTCT 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rCer/29/0_3927_CCS AGATAAAGTTACTCAGCCACACAATGGAAATAGACACAATAATTAGTACCTTTTAACCTTCCATAGCAATCAGTCACAGTCTATATCAGGGTAGATGCGAACTGTACCACTAGAGTGCACAGAACGTAATAGGAACTACAGATATAATCAATTAGAGAATGGAATACACAAATGCGAGATCCTCTTCTACACTCTATAATCGATTTATACACTACGAGAATGCTATTAAAGTCACTCAGAGAGATGAGATCATTCACTGATTGAGAGAGTACATATAAGCAATAAGAGCCGCGCCGTCGAGACATAGTCAATACATCTCTAGAAGACCAAAATATAACCCACAATTTGACTAGGTTGAGCTCAAGCAGCTATTAGAACACTTATAGCATACGTAGCATAGCTGCAATCTGAGAGCTAATACCTCATTAGCGGAGACATACACTTCGTTTACCCCGAACACCGAGAAAAAAGTAGAATATAATGTGTCACAGTGCTATGCTATGAGATTGAGAAGAGCTTGAAGAAAGAGTAGCTGTCCCCAGCGGATAGAGAGAGACCGCCGCTTGTGAACTCCATATTGCACTGTGACAATCGACCAATACTTCTACCACATCAGCACGAATTTGCAATATATGGTCGAAGCTATAGGCAAGGACTCAGCATGTCACTACTCCAACAGGTCTCATCTTATAATTTTGAGGTGGAGAGAAGATGAAGCGAGAGGTACCAAGTACGTTTATAGGTGAAACGAGATGAGACCATGGCAACGTCACAGCCGGAGTGACACTTCTCGCCGCCCTACCGTCCCAGGTGCCTGGCATAAGACAAGAGTTGCTAATATACAGTAAAACTATATTAAATTCCCAGTTATGCACCCAGCAGATATACATGAACGAGGTGCATTCAACCTTGAGCGAGGATGCTGCGTAGCAGATCTCTGCAACCACGGTCTTTAGCATCTATCGATATTATGGAGTACTCGCAACGAGGGGCGTGGCTATTCATGCGGGGCGGAACACTCACTGTAGCATCCCTCCCACACACATCCGATCACCTTTTGTTGAATGTTTATAGCGTATCTAAAGCGTACTGCGAGATGAGCACACTATGAGATGCATCACATAAAGACTATCGAGGCTCATCATGACACTGCTCGACCACAGACTGTCAAAAGATATTAAATCGTTCAAATCTAACACCGCGGTATGCAGTTTTTATCTCATTACATCGAACGGCTAAGACATTGTCACACATATCTAGAAAATAGTCTAAGAGAGCATCTCCGCATACACGCCTTCTCAGAGTATATTCTTTAATTATAGCACTCCGGATAGAAACGGTCGAGATATCTCTGAGCATGTGAGAGGTAACTAGAAGGAATACAAATAGGAACATCTTCAGCATTAACACAAGGTCAATCCATGCATATCATATGCCCTCAATATGAGCAATCAACAATTTTTCGAAAGCATAATGGAGATCTATAATTTTTTGCTGAGAATGGTTGGTTCTCTATATTTGATTTCTTTGTGAGCGCCCGGTTTCACGTTAGTTGATATCAACTGTCTCCATCTAATATTTCTCGTTCAAAACTTCTAGTCCCCTATCACGCTATGAGTTTTCTAGAGCTAACCTAGAGGATGCACTTAGCGCTCGTCCATCCGTATCACTCTTGTCATAAGTGAGTAGCCAGTGGAGCAAGACTTTTGGAGTTGCAGACTGATGGATTCTAGTGGAGCAGATAACTTTTGGAATATGGGACAGTCGGTAAGTTCACGCCCCGAAATGCTTAACCCACTGGTGGCTAAACACGACGTGGCGCGCGCGCCTCCATCGGCAGGTTATCCTGTAAGCTTGCTAGCGTCAATGTGCAATGGCCACTATTTGACATTCCGAGACAGAAAAGTCCTGTTCCCCGAAGGGTGACGTAGCACCATCTCACTCTGGTGGTTCCTCAGATCCAAGATCTCAGCCAGCCTACCCAACAAATGCTACTCCACTGGTTAGCCAGGCACGACCTCGGCACGAGTGTGAGGGAGGAACATCTTTAGGGTAACCACACACTCCGGATGAGCCCGAACGGAACGGGGCCCGAAAGAGGGAAAGGCACGAATCGGCTGTCCCACAGCCCCTATCCCCATGTTAACTCTAGGCGTTGATAAGCCAAGCGGGGCTTACTCTCATCATACCAAACAAAAAAAAAACAAACATCAATATAATACAGGGAATGAAGCAAAACTGAGAAAAGATAAGCCAGTGTAAATCAACGCCACAGAAGTAACATGGAAAAGGGCGGACTAAGCCCCCCCGCGCCGCCTTCGGGCATCCGGTGTATTACCCACAAGAATGATAAAGTTGGTTTTATTCAAAGAAGGCGAGCTCGAAAGAAGCCTCCAGGCGTCTAGAGAGTGAGCTCCTAAGACGACAACGGGTGCGCACCTCCTCAGTTTGAGAGCTATCCGAGACACCCAAAGAGACAGAGCTCACGCTGCCCAAGCTCCTTCCCTTCCAACGTGCCATGAAGCTGCGATGATTCTGTGAGGACTCTGTGTACATCTCAATGCCGAAAACCCAAACGCACACGGATCCATGCACTGACTGGGGTCGGCATCAGGATCCTTAAGGGCACACTGTAAGAGCGTGCCTGACTGAACGAGAGCGACACATGCGCTCCGAGAGCAGACCACATGAAAAGTCTCAACGCCCAACGCAGCAAATCAGCAGGATAAGGAGTTTCCGAGAATCTCCATGCCTGGGCACCGAGTGCTCAGGAGTTAATCTACGTTCACCAGAAGATTGAATATAGCCAGACTGACCACAACCCACCTGGAAAGAAACTTCGTTCTGGCCCCTCAAACCGCAAAGATGGTTTAGTTTTTAGCAGAGTACCGGAGCAAAGGACCCTCACGACCCCACAATAAATCTACGAATTTGTAACTCAGGATATGGGGACTTTCCCAGCCAGACTCTCTCCGACACCAATGGCGGGAGCATAATCTGATAGCCCAGAAAACCATTCTGAGAGAATTACTGGGTAACATCGGTGTGCCCACTCCAGATCCAGGACCCCCAACCTGGCTTGTACCCCTCAGACCCTTGCGGAGCCCAGCTTGGACATCCCCACTCCCTTCCCAAACCTGGAGCCCATCGGAAACCCACTGAAGCGGCTGTGTGCCGGGGGGGGAAAGTGAGGAAGTTACGAGGTGACACGCCTTCATCACCGGGGCCTCCAACCTTCCACAGAAACATCTCCTGCCCAGAGCCTGCCTGGGGGGTCCGAAGTGAGACGACGCCTGCCTATGGCCAATCACACGCAACCCTGGCATGTCCCTGACAGACAGGGGATGAAAGCTACGTGAAGGCACTGACTGAGCCCGGGGGAACTGGCCTCTGACGCGGCCGAACAGCGCTCTGGGCCCAGGCTGGGGGCACTGAGGGCCACACATACATGCATGAGCGAGGGCTTGCTCAACACGGCATGCCCGATGCGAGTCCCCAAGACAAGAAGAGGCGTGTTCGACCTGTGGGCCCTTCATTGTAATCTGATCACCTTCACAGAAGGAAGTGGACGCTCACCACGCTATGCTCCTCTGTTCTTGTGGGGAAGTCATGGCCCCAAGGACCAGCATGGACCAAGAGGCTCAGTGAATGAATCAAGGTTGTGCCACTAGCCTCAGGGCTTGTAGAAAATCGCCCGGTAGGGTGCCTCCTCCTTGAAGGAAAAAGAGAAAAGAAAACACTGAGTGGACCTGCACAAGATTTCCAACAGCCACCCACCTCTCCTCACCTCTACCATACAAAGGCCTATCCTGCAGGACCTGTGAGGATATGATTTCCAAAGGCCCTGTGAACCTGAGCCCTCGCTCCTCGATGTGTGGCCTCTAACCTCACCACACCTCCACCACCTCAACCATAAACTGTTCCTGC 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@rCer/32/0_1390_CCS CAATGCCCAGATCAATAGCAACCTCTTCATGAGCTTGAACAAGGATGGTTCTTACACAGGCTTCATCAAGGTTCAGCTGAAGCTGGTGCGCCCTGTCTCTGTGCCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGCGGGGCCCCAGGACGGGCACAAGTGTCAGGCGCCGCACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTGCTGTCACGCACAAAGGCACGTGAAGTCATTGAGGCCCTGCTGCGAAAGTTCTTGGTGGTGGATGACCCCGCAAGTTTGCACTCTTTGAGCGGGCTGAGCATCATGGCCAAGTGTACTTGCGGAAGCTGTTGGATGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGACAAGGCCCTGAGCTTCGTCCTGAAGGAAAATGACTCTGGGGAGGTGAACTGGGATGCCTTCAGCATGCCTGAATTACATAACTTCCTGCGTATCCTGCAGCGGAGGAGGAGGAGCACCTCCGCCAGATCCTGCAGAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCCTGCCCCCTCGGGTGACCTCTTGTACCCCAGGTGAAGGCGGAGAGCAGGCAGCACCAAGTGCATGCCGTGTGAGTGTGACAGGGCCAGTGGGGCCTGTGGAATGAGTGTGCGTGGAGGCTCTCCTCTGCTGGGGGAATGAGCCCAGAGAACAGCGAAGGAGCTTGCCCCTGTGTCCACCTGTGGGTATAGCCGGGTATGGCTCTGCACCCCTTGCACCCCTCTGCCCTCATTACTGGGCCTTGGTGGGCCAGGGCTGCCCTGAGAAGCTGCTCCAGGCCTGCAGCAGGAGTGGAGCAGACAGAAGTCTCCTCAATTTGTGTCTCAGAAGTGAGAATCTTGGAGATGCTACAAACAGAACAGGGTCGCGTTTGCAGGGGTGAGGGCCCTCATCTATGGGGAAGGTTTTGGATTTTGAATGTGGTCTCAGGATATCCTTATCAGAGCTAGGGTAGGTGCTCAGAATAAGACAGGCATTGAGGAAGAGTCTTGGTTTCTCTCTGCAGTGCCAACTCCTCACACACCCTGAGGTCAGGAGTGCTGGCTCACAGTGCATCAAGTGCCTTAATGCCTCATATGAGGAGGATGTCCCTGGGCCAGGGTCTGTGTAAATGTGGGCACTGGCCCAGGTTCATACCTTATTTGCTAATCAAAGCCAGGGTCTCTCCCTCAGGTATTTTTTCATGAAGTGTATGAATGTATGTAATGTGTGGTGGCCTCAGCTGAATGCCTCCTGTGGGGAAAGGGTAGGGGTGACAGTCATCATCAGGGCCTGGGGCCTAAGGAATTGGCTGAATAAAGATTTAAAGATCC 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S-23/5:;::793/43710+759865;5563788/75/55/5/9583635:5:37,2*,/-12<9?=+63<4::6:;9>8<<=6658<978;;05/..1.5784799482086;90689<6*431362;;:>2<987;;9#4568<(:69;/>><$:85<75466$53;'587652450'249164<9985;3412<9>;76:8<8<4>=9876972.234247A;5=:>47?@>A=A?CA?@B=@?47@5@=92<3A?7<=.<<=0?>=3796916359713757<%0./47;::07><5;:4:4:98;87141.;92)99:2;85=6;443199<=57::6<6=725=7<7783994675146/;;6735.2,/977:33/<<=;/007838;7;54752=)4->5030:8<;9=3298<<;==6?=?31;6<:6)6767176;3:/639075735235079<6656533321,102052.-$+0-/10;<:<:=;783'88.272966=8:2-9==:;<959:989><<=:?3297;5*2@?<0=7'0:028;;<:=@BC,C9B5?9><=;15:<;8<92>@AB;8/5<;AA:B?9:?849,4:;=0<7$0;0.59?:;8>990477<@;5A=B?;;?<15357756:582(25:BA(75475;<(>466C>FC887666A;9@BD>6A9>6683=><1>A<9?473??>@895@<=/72,1:;7425<:?:72;<24/7<%>=7>?A=6.A@>:<<=.2//7<3;;C5BB<:-4<7;8=B8;'=?=?HBDB7DFDAF:?,AC@E:4E:BD=HG>D;CDHA>CC9GG@CHEBH?D@EF8FB6A@GCB85?EB:EBC9AFHEDHHD>3D@AE>DCE9/B/>9CBDA?=FC@@CCBC(@<>F0029;188=DGC97=A<>@;FGIGJF7=8>=B>=@=ECGE8IG>'8/0&@E?/3;3;7839;-6:,3;=A=<>=A2<8:6=D:@@CBDFE8&58D=A04<1,;=:84=A4;@98?,@@B7.35/77@,94<>47=:-6.;@??><>?=8;=7C2?A?@?>:@?=6;?;=:99AA1>=AB;==>8+-3??A=:A;B-?CA2=1767<9>C;@>7<:95746032687:<>=?=;=<<;*=@;@C=9?@'24;/&458>6;;:9,'399A>A<49145==8;/6=:=5@<.;8>1;8:?87=3=AA0:3)479;,55<05=@B>9346<4A3<75998=B5-8&;:A5@5:7?B695<96@B;?5?EA?@A@< @rCer/35/21_2228_CCS GGAAGTGGAGGTGAGCTGTCGCGGGCGGCGCCCGGCCTTGCTCAACGCTGGCAGTCCCACCGTCGCTGCCGCTGCCGAGGCCTCCTGCAGCCACCATGTCCGCTAGCGCCGTCTACGTGCTGGACCTGAAGGCAAGGTGCTCATCTGCCGGAACTACCGTGGCGACGTGGACATGTCGGAGGTGGAGCACTTCATGCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCACCCATCCTGGCCCACGGAGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAATGCGTGCGTGTCGCTGGTCTTCTCCTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTCATCATCTACGAGCTGCTGGATGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTGGAAACAGGGCCCCGCGGCCCCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTCCTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAATGGCAACGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGGGTCTTCCTCTCGGGCATGCCCGAGCTGCGCTTGGGCCTCAATGACAAGGTCCTCTTCGACAACACGGCGCGGCAAAAGCAAATCCGTGGAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAACGACCGCACCATCTCCTTCATCCCGCCCGACGGCGAGTTCGAGCTCATGTCCTACCGCCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATTGAGAAGCACTCCCACAGCCGCATCGAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCAATGATGCCGACTCACCCAAGTTCAAGACGACGGTGGGGAGCGTCAAGTGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCGGCGGCAAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCCAGCGTGGAGGCTGAGACAAGGAGGGCAAGCCCCCGATCAGCGTCAAGTTCGAGATCCGTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCGTGGGTGCGTTATATCACGCAGAACGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCGGCCAATGCCCCGGCCTCGGGGCTCCTGGGACACACCTGCCAAGCCTGCCAGATGGAGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCCGCCCAGGGACCCCTGCCTTCCCCAGGCCACCTGCTCTGCCGCTGACAGTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTGAGAAGGCTCGTCTCTTTGCCCTGAAGTCAGTTTCAGGGAAGGATGTGAAAAATTTTCCCTTTTGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGTACCAAAAAGCTTGGCCAATGCTTGCCAGCCAGCCAGCTGCAGTTGGCATCTGCCACGAAGGAAGCACCAGCCTCGCCGGCCAGCAGGGGCGTCATTTTGTTGCCATTTTGTTGAATGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCGTTCGTTGCTGTTTGTGTTACCCTCACTGTCCTATGTCCCACCACGTCCTCCGGCACTCAGGCAGCACTTAGTGAGGACGAGCCCTCACCCCTCTTGTCTTCCTCCCGGCAGCGCCCGCAGCGGGCCGTTTACACGTTGGGCCGGCACCTGGCGCTCTCGGGAGCCACTGCAGCGTCTGCCTGCTGCCTGGACTCGCAGCCTCGCTAGGTCACAAGACGCTGTCACTCAGCCGGATCAGTTATTGACCCACCAGGGAGGTAGGGATCGGTGAGAGACGCCGGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGCCCTCCCTACCCTGTGTGTGTTCACGTCATAGTTACATTAAATTCCATTCATT 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@rCer/36/0_1757_CCS CCAGATGAAGCAGCTTTCATAGAAATGGAGATAGAAGCTACCAATGGTGCGGTGCCCCAGGGCAGCGACCACCCCCTCGTATCAAGAATTTCCAGATAAACAACCAGATTGTGAAACTGAAATACTGTATACATGCAAGATCTTCCGGCCTCCCGGGCCTCCCATTGCAGCATCTGTGACAACTGTGTGGAGCGCTTCGACCATCACTGCCCTGGTGGGTAATTGTGTTGGAAAGAGGAACTACCGCTACTTCTACTCTTCATCCTCTCTCTCACCTCCTCACAATCTATGTCTTCGCCTTCAACATCGTCTATGTGGCCCTCAATCTTTGAAATTGGCTTCTTGGAGACGTTGAAAAAAACTCCTGGAACTGTTCTAAGAAGTCCTCATTTGCTTCTTTACACCGGTCCGTCGTGGACTGACTGGATTTCACACTTTCCTCGTGGCTCTCAACCAGACAACCAATGAAGACATCAAGGATCATGGACAGGGAAGAATCGCGTCAGAATCCCTACAGCATGGCAATATTGTGAAGAACTGCTGTGAAGTGCTGTGTGGCCCTTGCCCCCCAGTGTGCTGGATCGAAGGGGTATTTTGCCACTGGGAAAGTGAAGTCGACCTCCCAGTACTCAAGAGACCAGTAGTAGCCTCTTGCCACAAAACCAGCCCACAGAACCCTGAACTCAAATGAGATGCCGGAGGACAGCAGCACTCCTGAAGAGATGCCACCTCCAGAGCCCCCAGAGCCACCACAGGAAGCAGCTGAAGCTGAGAAGTAGCCTATCTATGGAAGAGACTTTTGTTTGTGTTTAATTAGGGCTATGAGAGATTTCAGGTGAGAAGATAACCTGAGACAGAGAGCAAGTAAGCCTGTCCCTTTAACTGTTTTTCTTTGGTTTAGTCACCCAGTTGCACACTGGCATTTTACTGCTGCAAGCTTTTTTAAATTTCTGAACTCAAGGCAGTGGCGAAGATGTCGTACTCTGATAACTGGACAAATGGGTCTCCTGGGCCTGGCACTGGTTCTCCATGGCCTCATCCACAGGTCCCCTTGACCCCCTCTTCCTCCAGATCCAGCCCTCCTGCTTGGGGTCACTGGTCTCATTCTGGGGCTAAAAGTTTTTGAGACTGGCTCAAATCCTCCAAGCTGCTGCATGTCCCGAGTCCAGAGGCAGTCACAGAGACCTCTGCCAGGGGATCCTAACTGGTTCTTGGGGTCTTCAGGATTGAAGAGGAGGAGAGTGGGGTCAGAGGATCCCTGGCCACCAGTGCCAGCATGCCATGATCTTTAGGAATGGGACAGGTACCTTCCACTTGTTGTATTTATTAGTGTAGCTTCTCCTTTGCTCCATCCACTCTGACACTAAGCCCACTCTTTCCATTAGATTATGTAAGCAGTTGTAGTAGGATAGCAATTGACATTTCTCGTAGACTACCCAAACTTTTTAATACCTGTGCCATTCTCAGTAGAATTTATGAGATGCCAACGGCATAGCCCTTCACACTCTCTGTCTCATCTCTCCTCCTTTCTCATTAGCCCCTTTTAATTTGTTTTTCCTTTTGACTCCTGCTCCCATTAGAGCAGGAATGGCAGTATAAAAGTCTGCACTTTGGTCATTTGTTTCCTCAGAGGAAGCCCGAGTGCTCACTTAAACACTACCCCTCAGACTCCTGTGTGAGCCTGCAGAGCCTTGAAGCACAATGGGAAACCAAGCACAGAGAGGCTCTCCTCTCCTCTCCTCTCCCCTGATGTACCC 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S%/,,,.1211***$))*-'(.+0-,(0/100(,-,++)'*((./&.*0-/0,.-2/-*'0*&(*,+-#(*++11./1,.*.012,'*'00.2111++1,/()+/-,./20+*&,+,&.,.1112((#$(,/--(*&/(0/'(32611)-.%41(46$0&+621.20+,0265152321,-.1(/1/.04*+303-,(53142-$.3/2%-./)3*%20.,5,1..3+/.1$/-,*-2.613410+4-*-*)+)&&*/.0011(/&$-,22.-((*+(+-)++02*-.$'*-4,002'6.1,))($./1.0,%.55.6'2/,,#-(*,.0-$+**)(-.-)./1.61/52/)./&,+&"%&%-)--01)0/-3*250+2/(0.3)1-0.0/564//*'1*&-/)%$./+/+-$*(',*01..*),0),1/../-1,0/)042--16//522/,++&'-)'3&,.3.1&1,-10,%'1+..-/,036*).+/,,1,(-++*-,($-112-%,./1/),%#)-21*1+1)....(+-162/+32&%$()5997.43.011%44376,31881,255/2381:638947/::94.--383+6333%'$%0.30%/458:81145,1602..-*-%/-221-7231-6202*4.8148''*&#((#$+()$.((-(0*-&'12.*+&),$.01-)-,/)++-)../((+&+)+22+,,332+/3/4434032.0112/351$,-0.-/+-$(.&-**(1:08+3-2023/)/71774%,./--16980309=:?;?76:98,5::41;;,21(47-6)//156/2650350.)-4706499/57*4/00))+4/72444/61(2/1,9:9/84&,279,4/(461.53015.60/.04,.$&253025/59/60:9964)(6263)+*7963414771&154.54555'14,24-%7&-,-07;97:.65,9/%+2)1,.),")#'/0./2225'1-6./+21-#322,301,$4$&*-#)/17203'3&10+.527&1-+.,'-1(-'42,463-*&.&0,/$$('3',-.,,%.,(4.3'1.+*3(35/5(/-,21+,.494996,(4-%&03/13&413/*71210&*235*41,2/2-*#*.$3,,,.,23)3375-3(3/+35/,4/0/0-%.'67710./05,214,&)//&10-,4.2.142)+5.53&0*877455;9.355/53.50/**/++/303+%3/13222-3:3'(&'968$2/,*$+-.%4564''1+4294*3%$*/.13*36,51+*0/21-2705*5.)467&560.%2*520-4654**-/938.5*42-"+&1$.36120/-421*#$$/$#)(+1,$#00$7/38157'#,.08'02++0/3600*,0(%+)(2.,/*86-+)0187/53'*/321.',&#%-/#*/,%&)*+%*-+)2+236:2-10-,'+.2-/2.-14.222.4.53%.-563,'635;8498-.0-'*,&+3/3(6/0//6,18/75652)-997*9:709,.08099:6240+4-11/3043465%340//1(/,3851*7*&12435'4475:24./1598-30(3545-32203:2985584-3-2896;0*'(/403/303(/2451-*)&+,,//++).'1(-,(/01$'12/*.//(.-,4.00#20.$,1/6,'13(223$1*.55254,44/54+1'-2030*302455&)*0/1*$021)32 @rCer/39/25_1934_CCS ATGGGGGCGCCTGGTGGCGGTCCCCGCGCCGAGACGCCGCTAGGGCGGGCGGGGGTCGGGACGCCGGGCTGGGGGCGCGTCATGTGGCCGCTCACGGTCCCCGCCGCCGCTGCTGCTGCTGCTGTGCTCAGGCCTGGCCGGACAGACTCTCTTCCAGAGCCCAGAAGAGGGCTGGCAGCTGTACACCTCAGCCCAGGCCCCTGACGGGAAATGCATCTGCACGGCTGTGATCCCAGCGCAGAGTACCTGCTCTCGAGATGGCAGGAGTCGGGAGCTGCGGCAACTGATGGAGAAGGTCCAGAATGTCTCCCAGTCCATGGAGGTCCTTGAGCTGCGGACGTATCGCGACCTCCAGTATGTACGCGGCATGGAGACCCTCATGCGGGCCTGGATGCGCGGGCTCCGGGCGGCTGATGGGTCCCTCTCGGCCAAGAGCTTCCAGGAGCTGAAGGACAGGATGACAGAACTGTTGCCCCTGAGCTCGGTCCTGGAGCAGTACAAGGCAGACACACGGACCATTGTACGCCTGCGGGAGGATGTGAGGAATCTCTCCGGCAGTCTGGCGACCATCCAGGAGGAGATGGGTGCCTACGGGTACGAGGATCTGCAGCAGCGGGTGATGGCCCTGGAGGCCCGGCTCCACGCCTGCGCCCAGAAACTGGGCTGTGGGAAGCTGACCGGGGTCAGTAACCCCATCACCGTTCGGGCCATGGGGTCCCGCTTCGGCTCCTGGATGACTGACACGATGGCCCCAGTGCGGATAGCCGGGTCTGGTACATGGATGGCTATTACAAGGGCCGCCGGGTCCTGGAGTTCCGTACCCTGGGAGACTTCATCAAAGGCCAGAACTTTATCCAGCACCTGCTACCCCAGCCGTGGGCGGGCACGGGCCACGTGGTGTACAACGGCTCCCTGTTCTATAACAAGTACCAGAGCAACGTGGTGGTCAAATACCACTTCCGCTCGCGCTCCGTGCTGGTGCAGAGGAGCCTCCCGGGCGCCGGTTACAACAACACCTTCCCCTACTCCTGGGGCGGTTTCTCCGACATGGACTTCATGGTGGACGAGAGCGGGCTCTGGGCTGTGTACACCACCAACCAGAACGCGGGCAACATCGTGGTCAGCCGGCTGGACCCGCACACCCTCGAGGTCATGCGGTCCTGGGACACCGGCTACCCCAAGCGCAGCGCCGGCGAGGCCTTCATGATCTGCGGTGTGCTCTACGTGACCAACTCCCACCTGGCTGGGGCCAAGGTCTACTTTGCCTATTTCACCAACACGTCCAGTTACGAGTACACGGACGTGCCCTTCCACAACCAGTATTCCCACATCTCGATGCTGGATTACAACCCCCGGGAGCGCGCCCTCTATACCTGGAACAACGGTCACCAGGTGCTCTACAATGTCACCCTGTTTCACGTCATCAGCACCTCTGGGGGACCCCTGAGCCAATGCTGTGGCTCAGGCTGCTGCCTGGGGGGCCTCCGGGGGCTGGGGGCCCTTTTCATTCTGCCTGTGTCCCTCAAGGGTGATCTCTCTGTCTCTGTCATGCCCTTTCTCCCCGCCTTTTTGCTGGGCTTTTGTTCTCTGCCTGTGTATTTCTGTCTATTTTCTCAATTTCCCCTCTTCTCCTTTATTGATCCCTGCTTTTAATACACTTCTTTCTTTCTGCCTTTTTATGGATGTCTTTTTCTTTTTATGGCTCTGGTTCTCCAGTTCTTTCCCTGTCTCTGCCTCTCTCTGTCTCTCTCACTCTCTCTGTCCTTCCACCCCTCCCTCCTTGCTTCCCACCCATTCCTCATCCCTCACTTCCACCCCCACCCCCAGGAGTTGAGTGCATGGATCTGTTTCTTTTTTTATTTACACTTTTTCTTTCCGGTTTGCCGGAATAAACAGGACCTTTGACATT 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rCer/41/25_1680_CCS ATGGGATGACCTTACCTACATAAATATTTATACTAGCATTCACTATCTCCCTTTAGGCATACTACTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAAGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTTCCTCTTCATAACTATTCTCCTACAAATCACCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCATCCTTAACCCCTTAACAGAATATATAGCTTACCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACT + *-,2,.(/*(.)---*'0111&..*(#&(%%'&(,/,./.-'%)+,)+)0,(-$*$$'((&*.&%+&%//,.+-+-(*+,).1,&,..0%,501/410/0**.$1,*3543#.*36:835-022&5648%1'06%35378(('%-32+30%*/./01&01:::728;061:40(2//0.4881-4-3/=:47-7:96:;>8==1=9;78.3978::98<=*=:>8?>1685249<<9:;;97;9?/>714(/;9744<<4=>9;:*>>=:5(6586++$8)503==;;85754.7(57812;9-:77782*0-28;7:67?=9>3?8??>8;;>6;4:?;::8:8370745//?19692;=79+<=;.7;'988==8982876?3+;09/<:461:864>'8/=7(3<3,499;57;3<4=78997:6'920=:<,=<525.:109<8*;194.8/,=635(2>=969:4;4/93>91$941637>9,1.(,9=5>76>6,6(1502=:)05>;5;9,=$67830'.-1+>;;,*;2-*009;=0=18>7>9::887<.289./7;87.*56'47395672;03&,/13:=>6<:>=>=9>3>:<9-<;=6;61?>>=:??7/>=.=:.::;;;9;2=>8-=>7'878;8::>:8>::3;==;<:8=/<83.=:<747<:>1<:>49=::613=5=*=;-,)46<=20/384;3A=;5?<@>?@;*+<>?:6;;9,88.7028&;;4>1(;+447,3?4->61==7A8CC@B2?>?=7;;A>2:>@6?@;:BB>9C5@@><<52:9.A@18==A=+?<:35<@B>:8BF=;@9<@&9AEE7E+F><,8:B+BBD@CA6D;=@?5&9/D5DA===7D9C?;B5?A4D>+@B@)AAADD=;>9?4/=ED6C0CE=A2C9FA*A==>5@9/EB/729<3>8C?9D?.BD?99C,>B2?6;:D1F/A99A;@A?E9;D?C>%:-48BA?3D'D?<);4CC=AB?C@8/B9B=8C;#955?A?8?>@6B8EGE295AC=BDFFDD5EDAEB@D@DB8DE9>8A@A=BC>=?B3C49CCACC8>'D:A;?;G9CC@B@)B@)B;;@FCFE@BB@>*A?;;97*;;85A8@9:4:;64<18=:F@F@AF(D0==->>>A:>A7GAC8:9C.:4(=@BF59=>5?;A71@1>;.??::,;@BA?B*A43<9:?:?D8B=18:C95@;?.CB7;,C=AA5=<1AD:E4E79DBF:B81=?9;B7E=D6?D>FE?BC/?4<A<2?=;9DCFF<=?5A5/2;D=E:=:C?9@B4A57;@A:-,<1;573>::;/5863=<.'43@<7=->>B5?@?5=:AAAA=E@:?@@C?AB6=F@=BDEFCA<>A@B-C=670:AC)B>>CDAC@CD=C9AC*FF>=>=;@D:5;3?>?B9CCB=D7BDA<<=BDD@A(>=@@?:F93B>A@8C>%A@B*B@6*02)==/2+785(#)496@80(/62&/;7(5AA8=69(4%68<:=9$*.5-84&0&/=@6>B?A12A@7???=;3-?5.@2,-'(,:13+:&>CB=3?9@47,7C,.97>37C0836;3.>=><<9#55:@A<3?672+;*7/9.&8/??%>?>'A@A1C=A6)6;?76981DA;7.C71;F:G>/E<';74.35AC:6/.+1859>?<.%1*90'AB,A@>@=>3DD9B'-%50C161B3C1@=:0C/-B=7>CF?@(@:(':-><',;630%;556,B)0&C.8C5F;BBE,<)>A2'9*E?957/8:4"#B8<&>63C&@<2958689@=51'0&6.484>;?95/@17?6>@AD;7>.(*->A8B2@+1*@6E<.<3?(49E9(B,>(=@:;:DDB/4$?>:.1+/AE?3*%621@0;=D2(.&4C0B:EG8*05@>=6':@C(E46<=BA9:)B9BC'1#+4A08>@2B@1G@E4E=B+;=9>D?0+>/?2/E'>:3G+68&=,<-?-:;?;C@G9E.'CCE%&'/A+CB(E>';'>:*2''5*&:5(.)>;:*1+.1@5=+8A,*)+;7'3-4=9A4;B<7<41$%0.+67%==@@C.*0?:.(/2,7,#7(188/:$2+-56&2>C?+=+28+>(&1<>-@=;'%1;$1-78:6'<%(92'@@9;):;>97-%)47&1+>?50:9/3%8@-86:';7?3/4671.6@5272;8&4045:-3(#,#))63'52+098)$/$4;=9(*/=>=93>2/4,9;;.;-<>>>=1?;7<<:2>6498<629237./6*>>=3'9/65&),9,($+.,)+4=38+==<.2*1#263<9;+54;<);.+;/1751)7(.,)*(*(3'$++8<175(:2242/:9-&)1<*,%/276:%<;+;87=0>.B/24/;8.<<,,6$:20;?5?/+A+?*)0+5'63=4517%)-;188%#3//7-&=908<-65::3>A);<:2+02:774(48)823;.>;A=:;6<*==:-$363<.ACCB??BCBB53BA;/8A//A69B>)>:310@181%994*=;*33).<5'.59;<>*;4@)=+;<1(9%73?3<.A8-5<+>99=9%::9'-<)%505)<12)>'5;&;>,@/5-=/+&7@<.=1(;2<55.;CA/@7'.1><@+>40,%$5:=;6;7=&;=<%<149?>91'7'.64,*'7791=++.4*3?@@0 @rCer/48/1917_60_CCS ATGGGAGCCCGTCCGCCGCCGCCATGGCCACCACGGTGACCTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATTGGCAAGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATCTGGTCACTGGTGGGGAGCTCTTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTCGGCCTGGCTATCGAGGTGCAGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGATATCTGGGCATGTGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCCGAATGGACACTGTCACTCCTGAAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGATTTCTCAGTGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCCGCACCAGCCAGTCTGAGGAGACCCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGTGCCGTGTGGCAGACAGCAGAGCCTGGGGGTGGACGGGAGGGGGCTGCTGAGGAGCTGACCCACCGCCCCATTTCAGAGCTGCGCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCGACTGCCCTCGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCTGGTGCCTGTGTCTGCAGAAAACAAGACCAGATGTGATTTGTTAAAAACAAAACAAAACAAAAAAACAAGATGACGACGACACCACAAAAAAATTGACATCAGATG + ICHG/HAEK=:6K/9J9JKF=C8:@IAC+JA7DJKKKKJKJ?JKKJK:JIKGKHKKKKKKGKGJKIKKKKKGJJKKKJGJGK0K>BJA>?@D2KICGJJKKKCK6HJKJKKFKFKKK.K?GKCFJGKKKBKKGJIEEGIG?K1FGK@JKJK:7JBHHIKIGKJKEK.GD9IJKKKJJJKKIKKKKKJKKKIKKKGKKK@KKK/I@:I8IKEKKJGKKIKKAJKKKKKKKKKKJHKKJ:IKKKK.IJF=>%IKKFIIIKCGJJ/;KCKFIJKCK?IKKGKJKKKKIGIKJ@JJKKKK=JIK+KDKKKKHGK?FKJK>J@IKJKIKKFK?KKCKJK@KKKJDKIKIEEG-EKHEFKDK6JFCK.KIAGJB?=>HJIJ>>7CGK8HICJJJKHJKKJKI&GKKKJKKAK0JKKKH-I>K:GKI?JKIKGIJKK.EJK>GKKKKKKKHKKJKKKK/KJKEI@KKGJDJKJIKJKKKK:KH9KEJKK?KII9K7D4KK3KKI@KAGJ:CHKKKKBJGJJKKJ6KFK0K6KKKFJHKDFKK7@K&KJKJKK&KKAKK2JK?JKKIIJGJK>?KKIFK-KKKK*KI3KH2HJ@JJ)>>GKKIKF7IEK*DBBD=JHC@=GCJDKAFGH?HFGK3JFEKK>3FJKIJDJBKKIKBH@KDHKKKIHKHKKJKJKGIKJJKBHHDK>I?KI*KDKKBJKKJKGKKKKIHIGEIIKKGKCGGH>EIKBDJ9IKKKKKKKCEIJJBFKK>HJJK@?GJJHJKCKKGBKGJKKFKKFGIBKAH=@GIHK>9JKHJCH(BEGK?@JKIJ?KKFJ?JBJJHHJ4JE>>?=IAKJKDEJ?IIJ;KJG@JIJAKK-G=IHJB5IA>BE(I?IJKJJ-8=C$9GFFIKGKJKJI7IIJKKKACGKJAIDHHFI=JGFHJB:K?67HI+BK?IHJ>HKII>GIKCHBIEI)KE>@FJ6JHG9FF=GHH7FI$$@AA%IHJI+JJKF'FEBJEJK/AJ1JIIGHJJGD@G@&64IGHIKKKK(K0JKFFKJEGGKI @rCer/52/25_1722_CCS ATGGGGGGCAACGGAGAGAGACTGCAACCTGGGTTCCGGAAGTCTGAGAGCTGGAGCTTTGAAGCCACCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGCTCAGCGACATGTCCTCACCTACATGGAGGATGCAGTGTGCCAGCTGCTAGAGAACAGGGAAGATATCAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCAGGGAACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGAGCCTTCTGGAGATGCTTCCGAACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCTCACTCAGAAAGCAGCCAGGATTGTGCTCATGGACGACGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCAGTTTTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGATCTGCTGTCGGGCAAGAACCCCAACACAGTGATCGTGCCGACGTCATCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGAGGCCGGCATGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCTGGAAAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCGACGTTCAGAGACTGACCTTCTATGGGTTCCTCATGGCTCTCTCAAAGCACCATGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGATCTGATGCACGACCCAGCAATGGACGAGGAGCTGGAACGGCTGCTGGCCCAGGTCCCGGGCCTGGTCAACTCGATCACAGCCAGTCCAGAGGCCAGTTGCCTGCCCTCCCGGACCCCTCCCCGGGTTGGCTCCCCCTGGAGACCTCTCCACCATTCCCGAAAAGTGGATGGAGAGAGCGATGGCTCCACTGAAGAGACAGACGAATCGGAGACTTGAGGAGTCCGAAGGGTCCAGCCCACAGCGCCCTATACCTGCTCCCACCCAGCCCTTGGCGTGCCCACCCAGCCTCCTCTCCAGCACCTTGTTGTGCTGCCCTCTGCTGCTGACAAGGCGAATAACAGCCCCAAGAGCGGCCAGAGGGGCGCTGATGATCAGCCCAGCCAGTGGCCCCGGAAGGGAATGGCCTGCTCTCCCTGGTCCTGTCAGCCTGCGAACTTCACTCAGGCCCCAAGCTGACAGCCTGTGCTGAAGCCACCGTATCACTAGGAAGGGGACTTGGCCGTAGCCTGTTAGTCCTCCTAACCTCTTAAGAAGAGCGGTCTCTTCTGAACCAGCCTCTGCTGGTCCCCTGATAAGGTTCATCTCCTCACAGCAATTCCATTAAGGGGGAGAACCCGAATAGCCACGCAGGGCCTTGCACCATCAAGGGTGACACCTGCGACGCAAGTACCAGGAGGACATAACCGCTGTGGCCTTCTGTTGGAGAACAGCCAGTAGCCTTGGTAGGATGGAGAAGGGTGGGCCAGAAGATGATTTCACTTGCAAAAACTGCTTCAAGTCTTGACCCCTTTGTGTCTAATAGCTAAATATGTGAAACAAATAAAGTCCCTCGTGTCTGG + ID/EGJCG?>FE;BF?CIA?9IJHHCH>EEDJI?IHKCKCJIFFIIBJKJJDJKHGE3FIH:IH>H>$IFEEGF9IJHH>GIF>F<6F1EAFKBKGH7CE;?>?@C9AH@GEJIGHCJI?HFHHEJIKJKKGKJIJED=HCE&BJ?;EKHJDFD>FFIKEGIKHDFH0=IJIDH>G>?IHIJ7IHGJHKIKHEJH5IKIIKGKGJ>JIIEIG>?G?E@EEHHHGFIC7E@@HHCD@DB?A>CFFD??B>D<=AGCGGFG=CFC7>E<'@9CACHHF?D?EIFF4ECD?IEGCFCC<5@DC<.?ABEEGC::<@ABF?FCEDG?CBGE;HIGDH@D8G>>A8DIEBFGHHG7DBADHE9H?;8<=,F8CED7EGH?I9=B>BEDJFCDBA@<4<4B6=FIFHFJAI,F:A??ECAAEEDBGD@GHA0F=G??:C>EAGDHEBG(:@<<9EB;EF?9;A@FDH3=GCD5DEA4CC?;2:>?=DJGFE:FAEGFGFJFGECEI@JC9HEJEF8;EIEC@DF8D9GEHHH>KC5CJIIJH5<8EGKKKKKCHJK<>I3GJ7FIJGGB@:$I@FCGJIJFEDIEB?9IGAJFIGEKEIJ62AEFDDBI>HGIKFKHHGKJGIFK9IF@7HK8G>0IH@:/AIJ>GA8HGCAEAGJEJD?@BKDJ4ID?HJCKIK1K8CGIHDCA86HKHJCH>HGA2G=HGAKJH6KC6:5>AKFGEE@KKFAJKHG8KD=>;I?>,E=FHFD?G;>9D@ABECDCHFHG;JJGEGEGJCII@F=JFDI@CEEHAI@GG;JGHJJ;IB6J?>I;JKKGKKHIF@I2GGIG)IFFIHEF7E7HB9CJK?GEEJEKAFGAIAHGI4F:HBJK?IBFJCKJG>?H6=IFGCKAFKGA@FDJFI@HHKCFIGKF?AHFC7B:FJG=JEDA8JEDGH?JAJGCFIFBJGCJIGIHGJIJ82G9E>?IJ3JGHHFJEEDJE7H5?CGIJKKGKIHG5??II*EBFJB@CHCJIIKIIADGEFAD=AAB>FJ9EIA?AK;=FI?JK8HCICKFDHH4>BGGIJFHIE/DEJIJJHGJKH;KJHKEIIJ=IKJCKJEJKDFIBEIJHF,:BIIF=CC1:FII6JDG4EKJEFDF7JKG2KJDKIJCHCGKKHJHKKKKHDEIKHKJIJIKJDJFGHKJJJKKKJKJHKKKKKFJDH8KD2KF8KKGJKIJKKJGCI7IKAKIKIKCKJEJGKD;HJJJI@KJK?KJJKDGCJBK:JIKKKKJKKKKJHKKJKKKJH8JDIC>;KGHKK8KKFJKJGKKKKFJKKKH@5KKFKJCKKKIKKHKIJHHEGGKJJKKEIKDJHIJJGH:JHIDKHHKKKJ&KJKDH:BFIJKIKKJJAGIJJKHDFJFKBKKKGKJ?KAKKKIFKJJIGIKJJ;JDKIGCI>FJKKKFDKKJGKCKBK)KKGFHHKKJKGKDKKKKKJJIJKJIKKJKFKKK>JJKKJIK7HIGBCHGJHJFG;KKKKKJJEKK?KJJBC&JGEJFKIHH0IJKIKKKKFIHJIKKIIFHGKFJJJBKJKKJKKKKKKJJKHI?KKKKHKKK5I7KKKGKKIGHIDJJEKKGKJGKKJKKKCKKKJ8JH1HJJCK2KKKJJJKKKGK4KJA8KEHKKJDKKHKKKBIIJKGFKKDGJ:KKKJKCJKIAEJJKJK=KKHKKKKKKJKEEE:JJKCKKIJJK&KFIIDKKJHJKDKDKJEID@KK3KFGEKKKKKJHKKKJKKKKKFKKKKJGK@KJIHJEJ:KIKAJ4KKKKH3JEKIHJK?HKJHHJKKFIKHKJJIKKKKJJKJ0KKKKGJJJKKKDKBKKKGFKJKKKIJ?JKG?GG@KFGKKIJCKJFKJJKIIIKJH=KKEAKIKKKJK;IKJCK:KKKKKKKKGKK5KKIKKGIKKKCKKECKKKB>HKIHJ9KJKKE?GBIJIKKDKGKJKKKK5KKKIIKKIKCF>KJJJJJHH;JGKKKKJKJKKJJKKKHDJHJKKKHJJ8JDFGKKIK;JJJJIKKKI+KKIIHKJGD:KKKHJKJE6HGDAHIIIEJK=JKK8KKJCII9JKGHJI2JKKKHKEKJKKKDKCDAFIKJKKKJKJJKKKK5ADJKJ@KIJCEK8JKEJ?JJKJ0GKKDKIEKKKJKII?I@JGG?GK@DH@C,IG>AD3CKBBG4HJK=H;DKGDI;HDAHIJJJBKHHCCBEGIHDIHJFJAHHBJKJ @rCer/54/1565_61_CCS ATGGGGCGTGCGCCCAGAGGCGCCGCGGGAGGGGTGTTCTGCGAGCTCTCCGGCCGCTGCCCCCGCCCCTGCGCTCTTGGGCGGGGAGGTCGGAAACCCCCTGGCGAGACCACGGGCGGACGCTTCCCGAAGAGCTGCCTGGGCTGCAGCCGCGGAAGCCTCGCTCTAGGAAGCGGGAGCGTGCTGCGGCGCCCTCTGGCCGCTGCTGGAAGCCGGAACCTAGCCCGAGCCGCTGCCCCTCACCGGACGCTGCGCGCGCCACCGGCCCTCCGCGGGGCAGGGCTGCTTTGAGCTCGCCGGGCGCCCTTTGGCCGTAAGTCTCACCCTGGCCCCGAGGCGGGAAGGAGTGCGTGCTGTCCCGGCCAGAAACGGCTAAAAGGAAGGGCTGAGGGTTCTGTGCCCAAGGCGGAAAGCCGTGCGCCAGGGCGGCCCTCAGCGGAGATGCCTGCACGGATCCGGGAGCGCCGCTCGGGGCAGGGAATGAAAGGGGCGCTTGAGACTGGAGATTTAGGGAGATGAGTTCCTTGGGAACAGCGCTGAACCGTTTCTCTGTCCCACCCTACCCCCCGCTTATTTTTTTGAGGCAGGCTCTCGCGCTGTGGTCCAGGCTGAGCGCAGTGACGCGATCACGGCACATTGCAGCCTCGACCTCGGGGCTCAAGGGATCCTTCCACCTCAGCCTTCTGAGTAGCTGGGACCACGGGGATGCACCACCACGCCCGGCTAATTTTTTTTAAAAAGTGTTTCCGGAGATAGCGTCTCGCTGTATTACCCAGGCTGGTCTCGAACCCTTGTCCTGAAGCGATCCTCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGCGCTCGGCTTTTTACCCCTTTCTAACGTTTTCCATGCCCATCGGTGCCCTGCCCACCCTCTCTTGATCTCTAACTTTTTCCTCTGTTTTTTCCTCGCTGAAGTCTGTTGGCTAAAGAAAATTCATGTGCAAGTTCTGGATGTGAATAAAGTCCTGAGGTGTGTTAAGTGAAACTGCTACAAATTTGATTTTATGGACTGCTGCAGGCACATTGAGAGGAGAAACGTCAAGTATACCAAACAACCGTTAGTTGAGAGTGGTGGTATTCGGGTGATTGGTTGACTTTTTTTTTGCACTAAACTCTTTGTAAGGCAACATTAGTTGAATGAAAAGAATTGTGATAAACATAAACGTGATTAACACAGAAGAGGCAAATACTAAACAAGTCAGAAGAAACAAGACCCTCTCCAAATAAACAGTAATAAAAAGTAACTGATTTATTTGGTATCCAAGAAGTTACAATACTGCTAGACCTAATAGAATGAAGAGATGGAATGATGTAGGGAGAAAGGCTCTGAAATCACAACTGGTTGGAAAAAAACTTTAATTGTATAATCTTATTTGTCACATCCACCTGCCAGATGTAAAGCTTATTGCTGTTTGTGGAGATGTGCAGACCAATAAAAAGCCTATTTAATGAAAGTATCAG + KHKKK/KKKKKKKKKJK>KKKGCEKKK%KHKHKKKKKKKKKKKKFKKKJKGKKKKKK7KKKK@GKKKKJKJAKK=KJKK=JKEKKKCKKJKKKK7JKKKKKKKK;KKKK-KKFKKKKKIKKJKKHKKKKKKKKKKKFKKKKKKKKKKKFK>IKGIKKKJJKKKKKEHHKK&GKKKHKIKKKKKKKKK7FDJK:KBKKKKKKKIKKKKKKKKHKKIKKFKKJEJKKK=KBH:KK7IKKKKK(KKKHKKJKK1KHKFJKIKKGJKJKKKKKKJKKKBKKIKK0KKKKKKKKJJJHKKKKKIKK2JKKIKK+KKKKKJKJKKKKKCKJKKIKKKKKKFKKK4KKKKHKJKKKKKKKKKKKKKKK?KKKJKKKKKKKKJKKDKAJKKKKKKKKGKHKKK9KJKKKKKK>HKJ%KKKKKKK2KKKJKKKKKKK8KKKJKKKKKKKJKKKKKCKKIIKKKKKKKHJKKKKKKKGKGKKKKKKKKKKJKKKKKFKKKKKGKKKKKCKJKKK%JKKKCKKIKKKKKJKDKKHKKKKK@KHKHKKJKKKKIKK+KKEIKKKK-KJHKJKDKKKKKKKK7KEKJKIKKKKKKK1EKKK'KKKKKEKJKI@JJKJKKKKKKKKKKKIKK:KKKJHKEKKKIKKKKKKJKKFKFKKKAKKKFKKKKKK?KKKJKKEKKKFJ-JKK1KHIKKKKIKK/KKKKKKJ>KKKKKKKIKKFKKKK:KKGBJKKK1KKKK+KKHKKKIJKKKK8K;DKKKKJKIKKJIKKJ)KIIK$AKK3FKKJKKKKKKKKKKJKKKKK8KKKKGKKKKKK3KKKKKKKHKBJKKKKKJKKKKKKKKKKK@KHKKKKKKKKKJKKKKKKKKJKKKIKKKKKKKIKKKKJKKKKKJKKKKKKKFJIJKKFKKKAKKJKJKKK7KKKJKEKKIJKKJKBKJKKKBKHGKK:K:KK)KKKKKKKKKKKKJKK1KKKKKKKIKKKJDKKJKJKIKKJJIKEKJK6KKKKJKKKJKKKKKKKKKKK6KKKKJKK@EJKKKBKKKDKFKKKKCKIKKKIAKKKKKKKFKKKK;KKFKKKKJJGKKK=KKKKKKBKKKKKKKKKKKKKKKKCKKKIKKHKKIKKKKIKKKKKHKKKKKKK4KKKKKKKJKKKKKKKKKJJKKKK>KKKAKKKKKKJKKKHKJKKJKHKJKKBFKIKIJ7KIKJKKIKKKKEKKHKKKKJKKKKKKKKKKKKGKKKKKKKKKKKKKKFKAKKKKKKKDJJJHKGKJKKKJKBKKKKKK(KKKKKJKKKDGI=CJKKDIKKIKKKKKIIKJJE>JKKKKKKKKHKKDKKKIJKKKKJKKK>KKKIKKKKKKJJJKKKCKKKKKKKBJKJKKKK+KJJIKK8KKIJKKK @rCer/55/25_1759_CCS ATGGGGAGCCCCAAAGGGGTGTGTGCCAGCCGACCGCTATAAATAAGGCGCCTCCCAGTGCTCACCACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACCGGGTGCCGCTGACCGAGGCGTGCGAGGACTCCAGAATTGGAGGCACGATGAAGACTCTGCTGCTGTTTGTGGGGCTACTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGACCAGACGGTCTCGGACAATGAGCTCCAGGAAATGTCTGATCAGGGAAGTAAGTACCTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAAGAGATAAAGACTCTCATAGAAAAGACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAGGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAGCTGAAGGAGTTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCGGGCCTGGTTGGCCGCCAGCTCGAGGAGTTCCTGAACCAGAGCTCACCCTTCTACTTCTGGATAAATGGCGACCGCATAGACTCCCTGCTGGAGAACGACCGGCAGCAGACACACATGATGGATGTCATGCAGGACCGCTTCAGCCGCGCATCCAGCATCATGGACGAGCTCTTCCAGGACAGGTTCTTCGCCCGGGAGCCCCAGGACTCCTACCACTTCCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTTTCTCCCTATGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCACAGCCCGGCCTTCCAGCACCCGCCCACGGAATTCATACGAGAAGGTGACGACGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCGGCCAACAACCCCGCCCAGGCTCAGCTGCGGCGGGAGCTCAGTGAGTCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTGCAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCAGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTTCTGACTCAGGTGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAGGTCTCCAGGAAGAACCCTAAATTTATGGAGACTGTGGTGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCAAAGGGAGAAGTGAGATGTAAATGTTGCTTTTGGACCTACGGGGGCATCTGAGTCCAGCTCCCCGAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCATGTCACCAAGTGACCAGGCCCCAGCCTCCAGGCCCCCAACTTCGCCAGCCACTCCCCGCTCTGGATCCTGCACGATAACACTCGAATCTGCTGCTCATGGGAAGAACAGAACTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGAGT + CC*IIDFF1HFE8G=0ECECAEFCC@FAE>GI:9?:BA=896FFAHBIF@CJ?1DDGF@G?CA;BEEDFCBEGEDFHCH9DFGEIAEFC@AC@FEEB>H=A?GEH8HG@:=EIGCFG>A?A2C;BA3EC>EBCAA2@B7C8DABC;F9>A6D>9B1;>DEAEA0@>8CDFCEFFCBF:D8A;>4<=A=>6+CE8(7A7FDD='A:AAFA?=EBCE=FEB8D=?FF>>?A($7<4AB>@?>=7<$<7?;@6A=B;;&<&?<:8<:;BA=9?6C97)-59?@B<5;CAB0BAA@;>7=;>>@:@5A83@AAB@=?<<5;29817?>:<8=A??BBA>BB@:=?==?B<636=B0BA?7=8A*53<>9/9==?C>A?CC@>=C?CB77988:%9<@@:;7.4;:?@A=:A?C?@:9::>69@;A@7:8:;>;2??>C>:;9:;>56?89>:@6:;6>8@>=BC=A>B@C?B>;1.4;9<<-@7BC;8(>@@CB=&765;77;+7;=<>BB=@:>>=;CAA=A@@@>&@76=><>@C/=1BC@7=<9>?6B@B?35>?C<8>@4?@-CA><=07:AAA927?:B?BCA=A=?>;>?9C@4A=@5.2@?<@7CBBB6864@C>;>;>@A>C;2?6:=?9;+<7;)=6,9:;B54>@8CBB?>.A@>?A?:@<>=B?;-BAB@?>7@4CAC,BB::<@:>9=C9?89A?C@B>A>?7A?AA:<>;?@C7A>@;*B6B?==9B???><3>>88?48;;A:E=DEDC7=@8??<==;<;A>@>@5A@9=8C/A@3>';::9.4:8=C?>@B?C9BC?CA1B@=9=@=B:8?7=:;B=?;C05B>A?A@A?B>9@5@BB?CB<;/?A@B<4@AC>2AA9?A7@>=9BABA:?8>:?A@@7>4?:?;>=@C@=A:@@B<;=:<>6?:??-7;:@ACA?3C<48AB+=57<@2@AA;B>>@63@A'9<@9:@>4==C<:1?703==4A<>A<822:;9?@BB;:;7??A7;:<4@4@?79186B@:<>=>B=AAAC6@9?7A9>9?5=B<>>A><5B>@@?CA@B3@@>A=;?=B==B@7?;<'<67:=>AC@>A6B4BBACCAB?47A79:BA>CB6@58/7@8=A55B83AA?=BA>>@4>?@-C@<@AC@>@BB>;@A.@=:>0>@86BBB=?::B6>B1C=:CA5>=:AA:31=@?972??A91;;:B>BB8A9?:+659676781;5>BB>?:=:@:5;%<;4$79.6':<<:47=7???A=?::@==>:)1B@:?8)9A@66'70.774A89>3<9:=:=;A=?A>;=<>9;;4>5<<3;6+>;=BAA@=%37988=9:> @rCer/59/2155_53_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCAGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCTGAGCAGATTTAGCTGGGGGCCGAAGGCAGAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCAATTAGCTGAATTCGCGTGTGGCAGAGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGTCTTCCTGGAGATTTGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCACAGCCGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGTAGGAGTCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCTAACACCTGCTGACATCTCCTTTTGCTCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAACGCGTCTTCTTAATCCCACTCTAATCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + 32:A:5@=190D>=A?87F9DGGFAE@KJGK:KKECK36>*D;E.CB@J=65CJHG>=EJEFGHKK;DAC@BI*5+<&:7GJA4G<>$?IE0J?E+@&?G>)I=DG/=9=F?DC*,20.EJ:F@2=@B)IB:/E1KG;<&E8;@DEB)5A+:@>BK;CJDGF48>I4K?J@9@E@E9:CD?BGB,4)$AGFEC3C;I1HHAJE8EJ@FAB/EFKJGGK>GEJJECJHFABDC'AGEHC1D.@EEG=IEIBBK0DHIAHHHKAJ?A.H=AHFKH.I8DHE?F@FJ>JDBG.EDHIEJFDGC=G;A=>9;DI8JIJJ3@+C17/0IHF69I(BAAI*IIKI@:C85>D4FA;@>IAKEJ3II?@@0FFK3K+I1BC=K>KKI@JK&KHJKI)KKJKGKKK?KKJKJKGIJ,HG>J9>:I7K1AF?FFJE@CGHIKGJ'FGIH1J>HJFI-BG:FG?IIGHK@2AEK8H9BK%+1JE6JDFDH=GDIJJKG69K0?-KKG=IHK+FFBJKK(K=KAFIKKCGKKKFKHHGGA@>9E.BJA4>JH-KAKKKKKKI7HG@?I,JJIB;HJJDG-GF@@?A=C4FEKFK6HDH@I:IJKIFIKIEH.JIKIJKKFH?HDKIKJJIJKJKFJIG9$;K9E@BIJHEFHF'JIJIE,KKJJ@I3AF+&KDAJK6JGIKKJKKKJKII(53KK3D8J+KKHC@;GGCF@G2AAIBHK2KK@JJHIGJBC=HG,HJJIIA4@55IDHF3GI@BIA@@)FIKKCKIHK??B,K>JIIAKBH,GHCJJE-JCKJHJ9FGKEKBKJAII?DJ@JFE4K%>J6G?K:FC%E(%=HA7I;C8CAB=FJ+KKJFDJKDK&G=DJ3FJIIJHJJKJ8EKHBIGIE9ADGGED>$DCDI9FI=>FEK>IIB1EHH>G:HH'>>9EIEJ0IB?3H.HC(BGIDI6FKKCK>HG9A>4F;K32IJ0DEFFK9<+4K6J>%AFJ@GJJ,HK8G=?DD&8IG1>?IHGHFIJIIDHEIKJG<,7<@8I:HB::;FJ+DAKDIK8JK=H=78*=DDAAFJ=GJK;JJK5KJE4?9(=K07EE,DI@HKIBDB6CG>JJH)CE=AH8G4J3KDKK93EDKKJ)>=F9BI,HDGABIH1-JH0<>A*GI>G3FJHJBCGCE=EDE/09,CFC6%>ECD,=AKJ'8A9A6A-?@-E3A<-@0;6DGAGD5;*)1163-HKDCHB>;98;2@58G*A?@I@A3>I9?GJK9?2B->CA?>DKKCBGH3:@@CBIJ.HAGK0>A@):#<>FBGD79&8D*JC?>A-4C>88F.JCFE/HJ<)C78CC?/6CH7D79DFD2@&@EG,6CIJ/BH*4HE5?>B @rCer/62/1507_55_CCS ATGGAGTGCGTGCCCTGTCCGGCAGCCGAGGAGACCCGCGCAGTGCTGCCAACGCCCGGTGGAGAAGCTGAGGTCAACATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCATCGGAATATGTACCACTGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTGATACTGCAGGGCAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAGACAGATGTATTTCTAGTCTGTTTTTCAGTGTCTCTCCATCTTCATTTGAAATGTGAAAGAAAAGTGGGTGCCTGAGATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGACTCAAATTGATCTCAGAGATGACCCCTCCACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAGACTGCTGAAAAGCTGGCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTTACACAGAGAGGTCTGAAGAATGTGTTTGATGAGGTATCCTAGCTGCCCTCGAGCCTCCGGAAACTCAACCCAAAAGGAAGTGCTGTATATTCTAAACTGTTTTCTCCTTCCCTTCTTTGCTGCTGCTTCCTGTCCCACTACTGTAGAAAGATCGTTTAAAAACAAAGGAATAAAACCATCCTGTTGAAAGCCTCTGCGTCTTTTTACTCACCACCTTAGAGCAACCTCTGTATTAGTTTTGATCAAGAATGCAATATCTTATAGAAATTTTTTGTGATCAGTAGTCAAGTTGGACTTGTTTTAACTTTCTGCTGCTTGAGTTGCCTGATGCTCAGAGCTTTTTGGTTTGGATTACCATTGCAAAAGGGAACTTGGTCTGGCATTAAGAGTTTCTCTTGGAGAAAATAACAAGAGTTTTAACACTTCTAGATCTTAGTTCTAGATGGAGAAAGTAACACAAACATCATTTTACTCTTATGATCAATTGTTAATTGTAATTGCATGACAAACCTTATGGAAAAGGGTGACTTCTAGTAGAGTGTAACGGGAAGGAGGATTCTTTTCTGGTTTTCCTTTGTGCAGTGAAACTTTGTGTTGCTGTTGCTTTGGCTGTCTGTGCTGTAGTGGAGTATTTGTCAGTCTGGGTGGGGAAGATATTGATGTATCTGCTACTGCTTTATGAGTTCATTTGTTACGTTATCTTTTAAGAATAGCATCCATTTAAACAGTTGACTTACAGTTTGTTAATGTTGAGATGTAAAGCTGCCACTTTATATTTTCCTGCTTCTGATTTATTGTGAGGGAAATATACATTGGGTTACCTTCAAATTTTGAAATTAAAAATATACAACTGTTTG + =:=6>AF%CFBC/B.@/@A<:;:48=,664ADCCAA6>@8C8>@=B21'7B3BE@?>A>E?=4D=FAE;=BABBBA0=?:*<9A?(@E=DDA5<6=>23;%9@@@C9;=CIIAAE3@CDCH:G8?=5<)?>BA+:>/41,0/.=9;4@+><<=&C=?1<;6>:0$=<-<:9<'=53C5=?>3;@4>B>;7;9<2/$0,@:?4;93595.>63;9<;==??;?>>9=??%:84??0=7:9>6993:<<85=914=>,7=8;/2>;4?4A<7>71=23<>3<941;7;>A<8@7:A/4075>=4?@CAA1?6;8#0<><8@*1<=):B<&;>6?>?60<>?(?>=:,?BC<><27<8;2=@=@C:C>?B?=5@=81=8:?1=>9=>,>36159'7&:)8>@=;A6762%78>6??:>??:@=&=C@?8A9>6/>=><9+4+;<;@5>B65:+;;'&28A:8<<5A<774;3/7759:=/<7<>5>$6;@;<%@?@<<5<4824@428:;<5C:2&&7;78=>8849389:7.9+=@?.=27@7@B@:?;':;:>>7A=:4==>-;=89;;2:;.>.><585:B5?>5><>+@-A97;?B94366=@/@AA?;=77ABB399>8@69;.<8@CCA>=5=B>;=>0C:?@;7;.=;6BCBB?F;BC+B?@<>B;2?DDF*1D@69<<27=B>/;5<3:/:6>$,7;+><8<=<=74*9=?>B/A>@>B>9;C59/;924:C>732;-0178164227'9:=?C@BC?=A=CAC=9:@56=?<>>499@B>):98;3:/77889AC<->/A8=9A?@?@>-@5>AB2<2:6>?=><@=/>+<1&;?8=?98<87>84A?@@>C7;A<8=;70#&-)@4=>91289&59-<<6;:38=@(B*<>;A8/=@;A?BA>3>AA??<47AA2:/@2B@?A@BC9B;;?:=593;8:;B;=;@AB@=:=*@1>9>=91@A<-14(/2)$96<;:<68:::<57@:;96'77;.585?=?:BA@7B<;*?6AC1B>-@?=<775>>@8BC?B=@<95+),2>?6::83$0;;>(<5;<:<@6CC><=?A2@B;::44?7=A/998A@C=2<>A3?=,ABAC<;6;7==7C:9?27=B@;@?'<>?1AA2==89-68>>3>>7=<3A=@><)6;;=<9A?A8<8>@;25&4<2;:7BCC6@8B>?@367@?;:$9?:798;<9*.8)95553&30#-+?+:=5A=?A7,@AA,BCA>CB?=;9(?<473A,A=A<<2: @rCer/63/1517_58_CCS ATGGGGCAGTGTGACCGGGATGGCGCATTTTCTTGCACCGAGTAATGCGGTGTCGCTGGCGGCTGAGGAGGGCGGAGAGTTGTGTGGTGAAGTAGTGGGAGGGATTCATGTAGGCATCGGGAAGAGCCTAAGCCCACACTATAAAATAGGAAGTTAATGCGGGATACAGCTACTCCCGGACCGGCGGCGTGAAAGTCGTGATATCATCGTTGAACTATTGGCTTTGAAGTTTAAATCCAATGGAGAAGACTCAAGAAACAGTCCAAAGAATTCTTCTAGAACCGTATAAATACTTACTTCAGTTACCAGGTAAACAAGTGAGAACCAAACTTTCACAGGCATTTAATCATTGGCTGAAAGTTCCAGAGGACAAGCTACAGATTATTATTGAAGTGACAGAAATGTTGCATAATGCCAGTTTACTCATCGATGATATTGAAGACAACTCAAAACTCCGACGTGGCTTTCCAGTGGCCCACAGCATCTATGGAATCCCGTCTGTCATCAATTCTGCAAATTACGTATATTTCCTTGGCTTGGAGAAAGTCTTAACCCTTGATCACCCAGATGCAGTGAAGCTTTTTACACGCCAGCTTTTGGAACTCCATCAGGGACAAGGCCTAGATATTTACTGGAGGGATAATTACACTTGTCCCACTGAAGAAGAATATAAAGCTATGGTGCTGCAGAAAACAGGTGGACTGTTTGGATTAGCAGTAGGTCTCATGCAGTTGTTCTCTGATTACAAGGAAGATTTAAAACCACTTCTTAATACACTTGGGCTCTTTTTCCAAATTAGGGATGATTATGCTAATCTGCACTCCAAAGAATATAGTGAAAACAAAAGTTTTTGTGAAGATCTAACAGAGGGAAAGTTCTCATTTCCTACTATTCATGCTATTTGGTCGAGGCCTGAAAGTACCCAGGTGCAGAATATTTTGCGCCAGAGAACAGAAAACATAGATATTAAAAAATACTGTGTACATTATCTTGAGGATGTAGGTTCTTTTGAATACACTCGTAATACTCTTAGAGAGCTTGAATCTAAAGCCTATAAACAGATTGACGCACGTGGTGGGAACCCTGAGCTAGTAGCCCTAATAAAGCACTTAAGTAAGATGTTCAAAGAAGAAAATGAATAATGTTAAGCCATTCTTGATTGGGCCTCATAGCTTATTTTAGTCAATTTTTTGTCTTTTAGCCTTAACCACCTTTAAAAAAATTTGTTATTCTCCAGAAACAGAATAGGTGAATAGGGGTGATGCAAGTGAATTCGTTTTCATTTAGAAGCCCCTCTGTACAGATAATCAAAATTCAAAGTTGAAAGAATCAAAAGAAGCCACAGTTATGTAGGTCTGATTTGAATGTCATAATTGCAGTGACAGGACATTACTACCAGCTCTACCCTACTATCATCAATGTTGTGTTTATTCCATCAATAAAAAAGAGTCGCTTCCAG + <6>=9*872:592<<>D@8FCB@BC=@AD=)?>+C<=D564<9B1:;:<9A<;8EBFC6=C3:<>>@2;7?@@CD;4792=<=?B@:<8AA>DA@AA=8???E?@:ED5;4E=747A<<67=A6;<<7:67A=74><<;2><>=7<@:AB8C:7?>6<:@>>;><::1:<@>@;>87@B<8<9;6;9431@>8==?@A*?A69;8$6;1/A@@=<<5<;7:;7><79,8>=(75;;>:9>2>=:;,;@>;779='<91'::9;.:8<85<:2+@A8>7>@91>5<3:)@C984<74:8AA@B7A10@=?A@>9068*77/9=@3<@A6A59<;1680357666$80,6B>A=98:9,65<4<,44?8>@>@<9@@=514=89635:<;>;>$;<6;;<8959:;=3:@<=?>?A>57;=;>8?:8=7*473.;79869>2=9?=<699/673<@;@=:<9'@9=9@:>=<<.2;>A6=7/;298B;4A.?AC<9>B;9<47?>3<<@5842?A:9?9989;;<+<9@598;::9;=?C=8>=1?6>760659;=9*==0>:@77,046-0*70;==:@;<;6;88;=(;<1;610:49?8=12;<9357B=9>?/2;:+=99@0>44A37-?9:<>A893*98<8;69=0?><=<<;?>C;ABA8B6;?<5<;1C51./654@BC>>A-<7<;@;:0:27>014+5.),4=<6/9'1:+:5756<7465:6<64:808==59)>>?8,9;AA85>C?>-778:;:6.A<969>7A>C>@96=A5;5<9AC6<;=.;68=9<452:75;96>9?AB;C9@5@=;7'7=;5-94;7;7<;=>7A<:>A<7>::B?;7;;34825/*33===A<;2;256:734-,;1=8;966=7921<=>23A9=65=;9=@:;4=9=8:;5;988579@7<@6:<3<94>8:;0;8<>;691*-24+51-,9.8:,=><5>67<85;31'5;1/-8'5987:-81:77:14@CC9>@2,,35:616+43;6=>52573=):>6@<16:)>?=8:5*7+86435956,)785.'.;2;1;:97:)8508==/2/=09-81.(:9665*00/577$0:147553.,03/159;25<::34-3.048545<96.:7892;19568:0/'1;;?;9/8:86;94)4261*336>;5837/80/040.4%61844454)8=;,:719798:%4474<5%9<;<12=;9787/11/)13(33-86303:336%9589986413%3543,0872:4.33443/>;1;76038:697;57867992=<25<196::9>6539::3'989;6;898:87: @rCer/64/1613_56_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCTGTAAGCTTAATGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCACCCGAAAACAGGGTTT + 5476$9+0+94>=><:830,4/3+/:&33;2>=86<-76=796190874;1<9:;6>?:?<>9773<8964:<>=3>=97=959<78<=??:==;*+38<1;<=>:9+=>3:>>>>=70;5>=?96;8?=89:88<==2;;9=;/=537156;:-857>?>;=?>57$7??7;>>5:3:=47>;)<:727;8:3:?>=71?=<>?8=97;7;;<;98?7;>:9><=>;:?;=?9:7;(>>99287,:>;9(=;<;>???8=9>=?>59;-7:><===:85188$/5=>;=3=2+<=?9::4?9:5:8:,:;7=787=1:>6<<6;<4;<58@<><;@@='?:A:C;C9>?@A><5>B>79>B:=B8:>A>;=;?3;?8:><;%<<;70<<<65+$3:47??@;10%8.33*2:675;;>=5<7AA>?.B:<=>?>??ABB2:<,A<=*C@;C==CA;@?C@@;<;B@4?C@@>67;@66>9C?BBC:CB@?5BAAA<1BA;>?3<:68//.8<=&;=>.:?.7=>?5=;??A43=BA6:=AA=@96;;=299/A5B;05)25=6;;=<>9:>;6:@C99>47<=:?B>2:87A:C<>;=<<7;:=>?+=B4>>=?A@1@?BBA>-BB6<=A0:BA@@<;.@9<>6?><@>?>79A;?>=A9@=5@?7>A5;B9@C?A?==?>=C9:0:>ABA=7B;8@>B-A??<=5?<=>>A@>6<==5@;9>?9:=>&:A;7@?@92B@>?@<(;@AA?6;=<=>;9;/??:1;,?A?=34&=>>@/<:=8)>=8<=8?@?:B?>:?@=>27=AAA@3=36=+9CA=9=7=>1@/A8=?B?B>>???@=:@:@<>=;==@7:<>AC;8<@,BBB?;>9=3?>B899=8;9*3=67?=5(=7/;;940?<6B?9>6AB>A?8A58?B<;6;23<>A?=:;?@@2>4@>7>6.8:A0:;<<:.;?5274>2?7>=A:@7;<<9<=86(<@:->=C:@>=/@5<:1;>8?=6;@;AA>@9@B7=5<=3'194:;759=9?.@@BB;A<=5=5<=6;B=73)?C9A8>7@=3;;.88;@C6?A?<>@>7:CB?A@C=B?@BB?>@><>;<6?A@A2919;:=>&8*6:7=<@=6;39<67>9=<=8=9599;;@<77B?4?3<:>A5?=8@?-=A@>*AA69%==-56B=@3:3==@:9A:>:=?A7>7=>>:=<0=<>@A=,;67?>8@@3898,9@924;<@2A@:;6:@>3:21:9-*7<46*9;+?>B??;;?=0>>8?8?28;:51:0984)346:162;71=6<78:/6,3486+8341&0.0.4.$,)/&86;8/79;9327( @rCer/65/1666_55_CCS ATGGGTCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATTGATGAGGATCC + HJJJ4DJECJIHKEKJKKIGHJJJI>DGHHHGKGJII?IBBGIGECHIGCHGIICHHKKKC?DJJFGJJG6GJ?JKKDJGGF4KKHKKKK=JKKCKFKJHKKK;KHBBJJEJKFIJ@BHJEJHHC+FJ?GFIGIIK@JHI2FII0>GIHK@ICKFKEIJJJJKDIKJJHK5@KJH?GKGIID4FJHDKJKJAHIGJKGJJIJ9FJFIJKKC=EJ9JEKKDFKKI,HIH9:E8BK=FG/KD?EHF8DDHHJJHJB>FGI;JCID6EGEFCJDDECHICHDIJJ;EI>EFHHFJF@9G=HFC@IFDIGD0JGCH8DIJGFFJBDEEHI+HDEIIHJ@BGEGJDJGGHIJIEJCIJG7FB@@JI>GIID@CEEDGHIJGEFB*?FA9B9;CF=B5FBFE?E7><4B>BA;:CCB@DA2?C=C>*B>@A?7AC@=?BE?AEBFBGCEE?FEC?CE>?BFBBB4B>ABGFEBFDE>;9DEC>@4;D?CEE@CA0>ADABBBFBBF>;FFE?B?@G>@B=A7C89?AE*AEGEGEEAFCCE;F?>BB;-:9E=@CDBECGB;GDGCBG?FD;AEC;9EF@AFFEA8EF;D7FE<=CAFG>BAEB@BDBE7DDAF=GDFG>DBBGA49F;A=4><+95ACE8?=DBEFBBDD3>=0@C6FFEFF:CF;C=CA?DBFFB;;?GGEE>B?<5:1@D>;B;DDB@CC8D>@@@9=;BEF=:ADDD?E;G>GAGAGEC?C??ACCE9@7ABFEC:BDGFDGEDCBAC;>DCCF?CD:CE=FA@>AGFECE-7GCBBC=GD>F@A9@D9B=B3A3CD@C>6C;9EC6EC6GCFC@B@@EE@B=D>?FA>GABED6?E?:FAAB7DCF=@C?D?C@>:>CFEF;5???BDFC@@ABB@?FEEAFDA?>>@E@ACBE6FCD;=DGCAE@CDD4CB@GCGB;CGGECDBECCGFEBACA<?FF?BG=C?AB1=:7BBGBF@FEFFG=?A=9?;B>DC?DD@BC?ECBE?F@C8FDACEFDG;D@AFBEBE-EB>DEGFD:C= @rCer/66/2382_48_CCS GAAGACCGCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCGGAAAAGGCTGCAGATGAAGAGTGAGAGAGGAAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAAATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCAGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAAGAATGTTACTAACAACCTGAAATCTCTGGAGGCTGCGTCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAAGAAGAGAAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCCGGAGCTCCGTGGGTCTTTCTTTTCTCTTGTATGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTGGAAATGTCAAGCAGATTATGAATTACATGACCAAATATTTTGTATTGGAGAAGCTTTGCGCACCAGTTAAATCTCATTCCTTCCCTTTTTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTCTTCCTTGAGTTGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCATACTTTCTTAAGACAGAGGCCACTTGGTTCCTGGGAGAATAGGCAGCCCCACGCTTTGAAGACCACAGACCCCAATATCTAGTCGTGGATATACTTAAAACACTGAAGAGCATATAACCTTTTTGGGTCAACCGTTGGTCAAACTATAGGGACCATCACACGGGTAGGGATTTTCCATCCAGAGCCAATAAAAGGGCTGGTGGGGGCCGGGGGGTGGCTATTGTGGGAAGTCATAAACCACAGATAGATTAACCTAAGAAATCCTGGCCCTTCTCCACACTCCACCATGCAGAACAAACATCCTCTTAAGCAATCAACGTAGAATGCTTGGGTAATAGTCATAATTACCCACATATAGTAATTAATAGATGGTAATTAATAGATCCTTGATGTGATGTTCTTTTGTGTATCGCCTTCATTCTAAAGTTCTCTGGCCGGGCGCGGTGGCTTTCGCCTGTAATCCAACACTTTGGGAGGCCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCCAGCCAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTATGGTGACACCTGCCTGTAGTCTCATCTACTCGGGAGGCTGAGGCAGGAGGATCACTTGAACCCAGGAAGTGGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGTCAACAGAATGAGACTCCATCTCAAGAAAAAAAAATAAAATAAAAATAAAGTTGTTCTCTGAAGAGCAAATGTCTCATTCCAGTAATGACCCACTCAGCCGGAATATGGTGGAGTTTTAGTCCAATTCAGGTCAGCCATATACAAAAGACTACAAGTCATTCATAAGTTGAGCAAAAGCGTTTCTATCTATTAGCAGAAAGGGCCTCTCTGGCAGCAGAGGTTAAAAATTGGCCCAACTTCATTTCCATACTTCAGGGAATAGCAAATTGAAGATTTACTTATCTAGGACTTGAATTCCTTCTTTGGGACCAAGTTAATAAAAACACCAGAAACTCCTGATTAAAACTGGATAATGAAGGATTCTGTAGACAGGGCTGCACGTATCGGCTTTGTTTGACTTCTCTTTTCTCAGTTAACATCTCAGAGCTGGAACATTCCACATTCCCCAGCAGCGTGTGGGGGCCGAGTAAGTTACAATTCCGACTAAAATCACCCTGTGTCTGGCTTATCTGAATCCCTTTACCCCCACCCCACCACCCCACTCCTATTTATTTCAGCACCACACTACCCAGGAATACACTAGCAAATTGTGCAATGGAATCAAATCCACACTTTTCTTTAGATTCTTGCAACTGTATCATATGTAATAGTATCACTTTTTCTACATTTTGGTCGAATAAATTTTTACATAAAC 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+/,155+553560466/6-41/0-356165201+44/,5445114311,./,102+45633/10/)6403+300645/561/3,-&514,(1-0%1.252-54..0/3/-6-516224+546656446,1--3)).56451415011)*22*34211.6220+.44620.24)500/543./-44)31561.14,10/,,$(.4-64-1//..50316452/4,(302.50305/1.-46-42+4556,/(3500).0.4/021&1/*#.1(&0%**54053113(/43/145-//646+1433.2-5651.13+./)4530241+.664634+.,021,41/0053432001.++&)03*1.&,055,.2+*+*5515522*)///.''1*401501522)/.13,33/0/0.-'04+3/0032(,-21-41+131*065640'51122166260,55114/-0)10133/&3/31/041).5/041-01--//*%+&34*31+50305,42.16151/662444/.543.11-+56262.0#(/*13,+,.2-0'3244%54514.45516621*++-,4)2+46/54196:293388.15+653&32'1.212&23&*02-2$62699117,2.0(/34580*+64)57(833:4.*4-499,85+96-1+/42.+)032736'4.020210444-59/;9936/598,337871+53+0/51.3%3714)34:8254/42586647/4507956;743(.+&53101+455::3504:47327,23.78*0887::-)498,6.5232587.:74558871513226968;0728:27:65/1927:767,645804060526401002458633'/84-5:1334.+6+2026'./32441.1159:/4948,:03184353/38&35'4127/8345444720+,3.0'9620442)-51'6346*96.:1588.9:726/825/6454:223/&-0.-88;4/20769/2973-5&67'+(/42+47265-*00353876647924-3.25657*887/52514612(.1&$$%:-942364$-1-025-:3944,3,385)5(43466119026515:603.7-8976739+715:6421205.5233440851353&/10/1'3-.+0',&/6120151615601.23--.20'93265::685(2(5.:6/636.1%1-.36347-4313893696571*5./22.277/685-65/0-*-+*+'245-414-4,%,10+11(0-19601+2//.4727,:2,81023.+414523)7+)+,28479511+3)0/617576+5)6.3/%.')/5*6115,2/./3'68;875:4133155%-0370261-0-9906848280/785.41-'.223+*3&5486668/9478316254674677-63:328931/48/35238:05/,3&054/0,39793438:,431/.0515.6915887+1954556(4).+1264613-269;2.54440366817142.345/3:/68801)-+0(-/*015576*-/+54/43-465271''05072398/33-+156658*,%(%33,41&0/4130,2714514.46755275442653437058-/+3444541$/982,1/,14)-58185263.305224*883.785448871360-'.2-2/15/,443122--2%404/3/236072)+)/.%5866)/.:.422210*00-0.'+/32/.)*142(35.5,364,4/,2.3777337565%0//74444-/1-24-1332-,.&26.3522,344.341134455407688)%(4.25))'+3,4/06'1360/0/,4056/21552021,;1+-)3233'+$"$43752,5441*13-4,976-7871-6.2955-23,2,2-.24(1+0)#.634564643/5+/62%1-713670,7310246.--742040.25-13/839/61#%034;8-2/6-846;4388:63.6,222409/5-4586+1+27,5.4180618349622433--+-,./1/311123,/,92633&-3(),105,)'2,(+.26+2.0-/20+)0*/(808622.65320,05+')"'$#'&",*),$#1&(,(*'5/&&$3/12$)..%/*24202*5170005,05/3$4-240/16421.2)**,25./715-5799%+50,+3,332$356135,5000*12/*0*2/1,123203165/.83//2254855-,./9593/)6).-278594+5672(4431,/'0 @rCer/67/1175_55_CCS TTGGGACGTGGTGTCCGCCATCAGGGCTGGCGGGACGAGACCAAGCTGCTTGTGGTGGACAGGGAAACTGACGAGTTCTTCAGAAATGCAAAGTGACCCATCTCAGGAGCACCTGAATGGTCCCTGCCTGAGCCCTTCACCAATGGCGAGATACAGAAGGAGAACAGTCGTGAAGCCTTGGCAGAGGCAGCCTCAGAGAGCCCCAGGCCAACCCTGGTGAGATCCGCCTCCAGTGACACCAGCGAGGAGCTGAATTCCCAAGACAGCCCCCCAAAACAGGACTCCACAGCGCCCTCGTCTACCTCCTCCTCCGACCCCATCCTGGACTTCAACATCTCCCTGGCCATGGCCAAAGAGAGGGCCCACCAGAAGCGCAGCAGCAAACGGGCCCCGCAGATGGACTGGAGCAAGAAAAACGAACTCTTCAGCAACCTCTGAGCGCCCTGCTGCCAGCCACCGGTGACTGGCAGGGCCGAGCCAGCCTTCCACCCCACCTTTTTCCTTCTCCCCAGTTACTCCCTGAATCAACGTACAAATCAGCACCACATGCCCTTTCTTGACAAATGATTTTTCTAGAGACTATGTTCTTCCCTTACCTTAGGGAAGGTGAATGTGTTCCCGTCATCCTGCAATTAGAAAGGAGACTCTGCCTCCCTCCTCCTCACTGAGTGCCTCATCCTACCAGGTGTCCCTTTGCCACTCTGCTGGGATATCGCTGGGACCTGCACCATGCCAGGATCGTGGGACCAGGCGAGAGGCACCTTTCCTTCCTCCCCCGTGTGATAACTGGGTCCAGGGCTGATCATTGACTGCAGAACTGCCACTCTCAGTGGACAGGGCATCCGTTATCCTGAGAGCTGTGGCAGACACATCTTGCTTTCATTTGATTTTTGTTGTTAAGAGTGCAGTATTGCAGAGTCTAGAGGAATTTTTGTTTCCTTGATTAACATGATTTCCTGGTTGTTGCATCCAGGGCATGGCAGTGGCCTCAGCCTTAAACTTTTGTTCCTACTCCACCCTCAGAGAACTGGGCAGCACGGGGAGGGTTGGCTACCCCTGCCCATCCTGAGCCAGGTACCACCATTGTAAGGAAACACTTCAGAAATTCAGCTGGTTCCTC 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rCer/73/987_56_CCS AATACTCAGACTCTAAAGCCAGGTATCAACTGACACTGTAGCTCTTCTGATGGCAAGAACTCAATGCTGGTGCCACAAGCTTGGTCTAGGACTGGAATTTCAAGCATAATGAATACTGTACATTGTTTAATTTTAAACTATTTTGCAGCATAGTACCTTCAGAATTTAGTGTATCTTAATGTTGTATGTCTGGGATGCAAGTATTGCTAAATATGTTAGCCCTCCAGGTTAAAGATGATTCAGCTTTAAGATGTTACCCTTCAGAGGTACAGAAGAAACCCATTTCCAAAAAGTCCTTTCAGTGGTAGACTCGGGGGAGCTTGGTGGCCCTCTGAGATGCCAGGTTTCTTTTTATCTAGAAATGGCTGCAAGTGGAAGCTGATAGTATGTAGCACTTTGTAAATTCATATTGAGTAAATGAATGAAATGTGATTTCCTGAGAATCGAACTTGGTTTCCTAACCCTAATTGATGAGAGCTCGCTGCTTGATGTGTGTACAAACTCACCTGAATGGACTTTTTTGGACAGATCTTCATGACCTGTTCCACCCAGTTCATCGTCACCTCTTTTACACAAAAGGTCTGCAGGGTGTGGTCACTGTTTCTTTTGTGCCATTTTGGGGTGAGAAGGTGGATGTGATGAAGCCAATAATTCAGGACTTATTCCTTCTTGTGTTGTGTTTTTTTGCCCTTGCACCAGATATGAAATAGCTTCCAGGAGCTCCAGCTATAAGCTTGGAAGTGTCTGTGATCGTAATCACATGTGACAACACTCAGAATCTAAATTGGACTCTGTTGTTCTCACCACTCAATTTGTTTTTTAGCATTTAATGGGTACATTTTAGAGTCTTCCATTTGTGTGGAATTAGATCCTCCCTTCAAATGCTGTAATTAACATCACTTAAAAAAAACTTGAATAAAATATTGAAACT + 1+#4.8:2*($-/(79754&>6%@B<6?(2@D<CD=<%DCA(>F95?5#6>I8IF<>F*;:<.EGE>FEH4=2=?EA?&F:FG699CG2>JDC837G%3%@.FE?-B?<4(79FIE:KCKFH/HB.AJGIHJ0JAHE&6D@&<8<,B+>/@::D;GCE2K=FCCGDGIHHE(GDDIK@HF?>/@96FF3F>:;H;6>JG+5F*FC:F5:C%B:;2>K9H>@HJK9J48@:7A4BB;$I;%9>BB5H8)2EB<@IK:BJ3HKK174KJJK&1FH4KK8II1IG1@HD9,JCJJJI&>>GK;HAHA.CG/8BFH9CCE)F6CGBC/%&79?-?9*&@D3AC2;7BD9G=1%B%CBE9DHF?9':<>CJ@9@5;&9.F3.EF?8%C>B,EH9E6AG9C@%BIDD24D>A=2>/'5BBEFHDE=CE;)$99.8=7EG::=8;B5B,D:=C+@:>BA<<&E.F@D?=B:F(A?F@C@/8-D6B'-:F1B.E1-BH83;0B:%=EHII8HG=')DF):1B-,9E./9A6ACFF3:C@=,;66?.DEBF:F@?032<0F>?/@JIEA8?58+&@=IJ>C%I;5D:;7.F5;:9ADHHGC+CG@;B)/GBC8<;$.11>5-08-.CBE?;?-9:5FJF>G/IA2+&/>BA1#**CF?=E7D9HCD4;;$79:?DC'HGH-ADEG:>.2@D&/8581+I;:,;D;HCI+@A=C>CJH>G:(FGEF>C@I==H<%@=F@5@G@FIGD>JBIG@E@FAA78@3;@E@A5F=A=D87C@B@DE8G>>H@:B@:CA@CHGGECG?EHF;DFBG?DFIB>AH?;3ADFAD5DEFBC-?HCAFA;>F67?A@CB;4>D1:32=4IAC@D5C)BE@:EFBF@C7EHGB5=30HCGFHDJIGB3GHDA=FD6E>IAEAC<7;GG:A?>CHB6ACH>CE;FC@9GDG>BC?HB7GD?G8A?EAJC?FHH:A<:BEFABG:I@9E7FCGFEFHE:8F9CDAIC@B7:B@C@8F2HD:4<>?<@GC@.E:?BBEFB5EED1D7A>B@EF5BHFHADGB@CIEEJG;@@DFAEBG=F>CBDB=BIFECC9HFG>EDIA<@A>=G9H=5BCCDCCIIC08AFCGGGAFDFDIEA7@C>?F>>9>JD>E>HCCJJHHIHBD??,B@C@>G?C;ECF:C<:F@GDD79H9;;D<8CADHIEFI&CFEC>>850ACB9<FFG2A>1CF8C4D:B4?ECC>FAI6FB@G:E?8HHBG9CCG9HHD>BE>HI=?BDGIDIA6B@;??EBA@DEGH6D3ADC?DGAE@0E?7?>-(6BFGHEDEG46?78=57AA?@C?E@@DI:9B?;JIBFH>HIGJAI:DIIEIBDJJFBJJ>9D6?E=B@@ACEE@<0$6=C=AAIHGI?JI4FKE@BF4CF=;=IHKHE6>F@JJFA?HGE8EHIKEJJ>IIAIE9;FFFCAGE<17A6GC:709;9FFIF<>H.C);8GI8C4B;A@??>9;BE9@@>5D:51=4434<=@1B=HFJ;DIHGGJB@K?KDHHJJKIHFJDI@HFH>1FJAGIJHDK3I>JEG>AJIJHK;JJDJIAHH:EI>GBIJFFEK;D/F?D4ED4HBB:JIIJE2IHH@FAJDCI;JJKHKKEKCGFF?G?FJGJH?IDFEEE1GIAI@HKKJ%FIFA21D@>GKGKE7H-JGE8E==I:1EHJ%EGCD;JJIGIIJH:82GFHHGJFDB;JIBFJDAJDDEC5E@FJ2DACECIB?IBKCHHGCH:AFK(EGHGHHEK @rCer/77/1073_58_CCS TTTTGATGACAACAAAGGATGCTCCTTTATCAGGGGGCCTGACTCCAGCTGGTTCTGCCACCCTGTTGAAGCCTGAAAAGGCCCAGTACAGTATCCTCTCCAGACATTGCAATTGCATGAAGACAGCCCCGATTTACTGGCTGCTAAAAGGTGCAAATCATATCGGAAGTGAACATTATGAAGTCCTTTTAACTCTGAGGAAGGCATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTACGACATTACAACATTTCGTGCTTCAGTAGGTATGTATTTAATTTCCAAGTAATTCGGAAGAACACAGATAACGTGGTGATCTTCTCTGAGAAGGATCAGATGAACTTACGCAGGTTACATATATTTTCACAAGGCTCCTTCTCCTGAAGAAGCCGAGGAGAAGTGAGAGCTCTGAGGAACTCTATTGTTTGATGTCCTCCGCGCAGATCGAACTACTGCTGCCACGGCTTGAACTGAGAGTCCCATTTCTAGATCATCGATTTTCTTCCTTTACTTGTCTCTGCCACCAAAATGAGAACTCCAAAGAAGGATAGAAAAACATCTTCTGAGAGAACATTTGAGAGTCCAATCTGATACCCAAAGAGATTCTCTGCGACCAAAAGAACCTTCATGATGGAATAACTTCAGTAAGAATTCCTGTTTAAGATTTACAGGAATACTTGAACATCAGTTGATGATGCAATGATGGCAAATGCAGCCCAAAATTCCCTTCAATACTCCTAAAACAAAGAAGGATATTACTACCGTCAAATCTTGAACGCCATTACCCAGGCCGGCTACTGGCTGAGCCATACTGGATGCCCAAGTGGATCATGCCACTGACCCTTCTGCCCGCACACTGACCCACTACAAGTCAGCTGCCAAAGCTTAGGTGGTCTTTATCTGTAATGTGAAAGCAAATATTCTTGTTGTTGTATGGGACTATGGTAGATAGGGAACAATGAGTCAACTCAGGTTAGCTTGGTGTGAAAAAAAATAAAGTCCAAATC + ,*)',,,+,+"&$#('(%&"$.%0,)*$)*,&)//.%-00$,.,601-,%+*3'2/'-*443)',.'-.&$$'&063&'&(/1%%,2/2-/)3(-*22221/*0004-0/-)0()2-*+40/.,*/61501546//201)5411/+6601/,$26642/511351+6/-5/41411.1),3.4530253)6,33,05431602.4165410)/,545+33)61+2/.--*01%63644)1/+-$/2,0450.421+4*'2%3(*/46653+2+-+/3)(1431(604.*2/1/31$*1&12)0-0301-2.114652.-/)-,-.4603-2-%--6011/,34012+3'00+0/1/-0#((521/1*0+44*//'522%+)((0*,0+&/665/2))60+*)$(%&&)'*.1*$,$2-0-/)3/1-.-.0&.56.0'1301)2/%45432566502*3220231*-3$+0-%$),(6403./.-*.30)*552//1.(.)0.4/0/42*06/2/#%)222(-,.,)&'0,--,$02,10*$1*,-1+/0%%1&(&,(*%/10.'(%%0,$-0,(%*)''))..$')$))*/)0-&.%%-+)-,)./(*---+'+/+*&-+.1'*//#.-$+,,&0'&*0//,1+%0(,1-1*$$--00*.,01.''-'0))'&+&-,.-*2/',&'%&2111+/**)$%1-,1.'+./.-0$)'.-0)%&+')10+)-,'0&-1,1+02-,111210/0,(&*0*)0),,/(0.&--,121/%.10*/-/*02*),-./0-02,-./)0.#"'"./-+++%+,00*,#)+)/*/,*20+1,,.1,/.+#"..*11-0.0,&'&/&-02.+*/-/($$$12011+&-2/&011001,/%//&,++&0.',+%+*,,,)#+&/)-,),-,-*((+++$+)'#((')*&+.,),'(-**-+),(,&'')--+,))-&++)%%&',*,-,('()(,&+,-,(,%+,+(&)++*))$$)(#%+-#,.*), @rCer/80/224_105_CCS TTCACTCGCTCCCACGACTGAAAGCACAACACTTATGCGAGCTCACCCACTGAAAGGGCTGCAGGCATGGCTGTACCCAAGCTGATTTCTCATCTGGTCAATAAAGCTGTTTAGACCAG + )'&(&$#'%#()%$%('%&%%%%'$'#''((&#"%$""$&(&$"$'$$%'()))('*++-,*1---+(/#(/,''(+$1-,00*122--&,+,0(2,.00(++'&*'(*/.,-/+304/ @rCer/81/30_1998_CCS TGGGAGTGTCCCAGTGTGCTGGATGAAGCTGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCCAGCAGCAACCGGGCCGCCCCCCAGGATGAGCTGCGGGGCAGGGGCAGCAGCAGCAGCCAAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAGGTCCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGAGCGGTCCCAGGGTGGACTGGCAGCCGGAGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCATCCCTGCCCTACTCGCCGTCGGCTCCCCTCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCCTGAAGGATGAAATTGGAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAAGAAGCTGATCCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAAACCGCTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTTCATGGCGCCCGAGTCGCTCTCCGAGACTCGCAAGATCTTCTCTGGGAAGGCCTTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCCGGGCCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGGGC + F;JA?KGJGBKEJHIKJFDBFKJJGHKIK@>KIKKFJJI;GKIII@JH;I??BBDIBCEHJBGHIGAKIEHJJH@AKCE3IDIKI)FFGC?B?GFFJGGHAKK)JHKJG)IEEHGFI>>FFBD@DCKCKJKJKKH?JJ;FEBG7IJ7HBIJAJKDKKICKE@JI>@IHGKGKKHE,<;JHHK:GHEAJHKJKK@KBIKIBKCJKKKHF-DH;JEJGGKIDJ?EEHIKFFJJGE:KBFK5JHI<>KHK>KKKKKDDJ8HEJKKEEGF?H>JKGICKGKIKFJ@KJ(KJIIBHIHKFIKEFD>DKJAKKKAFBFJHH;KKKJGKJJDJKHKFKKKJKAJGKJGJIGIK=KKJKKIKFBKKI@KIE=KKKKIJIKKIKGHGAHEGEEDFAJJIKHFKADGIJKKKKKHJJJKKKBHKGJKK?KKID?JKKKJJGJ9EKJKK>K4KIJJJ@G:8@E@IEIJCGKJJKK@KII;JJDEHKII,JJKJKJKDK7CGKJCGKKFIFEJDJDK@KIJJDKKKK'KKKKKEKKGIIKIAKHKCKJKGK@KIDKK=KHJHFKH-EEDHFA2@IKKK?KHEIKJDIGHIKKICJKEKGHKKFGJCJHKKJ?KKK.KKKGKKKJ@JAJCKKIKGJG.58KKKK?KKKJ?KJJJJKKJHKKKF6JEIJJKIJKHKKJFKKKKKAKKKJI>KKIKCHHKHKKKKKKFKJ5FJFIKKEKKHKJIKIJKDDJCFJKK;KJCKK9KJGKEKKKKK:KKKJIKH>CHDKKKDK=KBKKKKKKK@KK@KGDKEF9FE?HKIKJ?KEKKIKIKKJ7KJKEKKJKKKJKKKKGKJKIKKJJJHJJKIKIKKKHJKJIJKEG??KKIK?KKJFKKB?JKJJJKJIKJKKKKKKKHKKKKKCIJGJKKKBKJKDKKJKIKHKKKKKAKKKKKKKJHKKK=KJKJKKJKKKIJK:KKKKKK?KEKFK@HHGKHKKFKHJKJKKKHIKJKKJKKKKKKKKCKKG?IJGH?IIKKJ6JJJDKJGKCJIBKFGKIKKKJJKKK?KKJEJKIJKJ8KKKKKKJKKBKHKKJKKKJKKICKKJK7KEIFIKGIHIG='KKKKKKK@KK8KKKKKAKKJKKKKI&GKKKIJHJKKKDJFKJJKKGJJIIKKIKKKKKKKKKKKIKK>KJKKKKJ?KKKKIGKKJKJKKKKKKKEGKKFKKGIKKKKKIKHKJKKKEKBKKK0KKKKKDKKKKKI8@7GD5<-B9?CF@BD8;@C7F@>@;G1='8<@C2@C:=:B@G3DB4??@@8B6?@<9:8;3&A8>>BA?CCD7B9CDGGG6BB1D0EFEEEA?0D??@FAE8DB6@@@C@F@ED?DGAD@CGGAC@>?C7@EF9AD8?B@ACG6@BD7=AE@A<@AE8:>=B9A@?@8FA<80>AA@B;;EBA=D>7@(AEE9DDDB6BFB=C9;=ADCC'>>F?9CFGB>AC@0CDD2A8DBFCDAADFGG?C-DEDFFDE>BF;?A@@25C>E>CB?=CDCAAFE6:EDAE@=F?EBB;E@,>;9??;0>C1-6<.?596@C@0?EB97>EBB7CB4D8D=>@>27<<=:>:>GAGD5CGCE?BBEA5:B<>=6D>@FEA8J>@A27E@8;9@6AC6:@,B8;EAF;@;CB>D=<0FB>:AB8C?E9>9G<3/>)..:)7@?>A,>C;@?D8>A@E<78A2:ED,EB>@D:C>3?:C:FB@;.8AF>B=FG:FA@6B=A@09;74A>@C-B=>$?@A:5>,;?;EGFBC<:BABC4?D@?;;DBC@?E?:A?CA4?E>?3B6F@FEGA6DCCADBD5GCDD@FECC@ED9E78CD58D@;>FDC6BGCCB?5>?EFF92>;<<1BC?28A@=A:?@B549@959=DD?F:C??ED?@4B5CA7D;@DAEAFB>=DBACAA-<9C>@@3:897@<6@=4;:?DDB=D5;F;DBA=C:?@-9@:;>FB/:<63:<;:>CA>=C9A@5?4@A?C=?-::9?3A@2<=A;>?=B?C7;3<*@><4=@>=5=@CC9AC:855-588;<:5<68,=5==77A<@?@?;;6=AB=AC>@?C@=?4;?3?;A7<2<>><6=.;A2??<=7@=0@>;5-783<;:??:'<<=2-:A?6A<;?>C>?7@<636;@>=<@=A@8401;@?;@4?:58<3@B:=>6>B=9><>B?;;AA:@=6>9?6A1=;=@9<:?':>;<)@@98C<>?>=7;9<-;4;?=07:9<80?:@5@>B=:<:>BA:B?@?8=2=?@C@@>@>=89>6<6?>7.==<>?.@=>9>@;><<'+>(=@=99:98:8?>6>=@>>=0@?;>:79?:8BC<79/<=9;>6=>9 @rCer/85/2436_57_CCS ATGGGGCTCTAGCGGGCCGCGTAGCGGACATGGCGGGCTCCCGGCTCCGCGGCGGCTCTTCCTCCAGGGCGTGGCGGCCGTCTTCATGTTCGCCTTCGCTTCCCTCTACTCGCAGATCCAGGCCTGTATGGCCTGAGGGCATCCTACCTGCAAGGAAGACGCTGCGGCGCAGGCAAGGGCCGCTGGCAGCAACTGTGGGAGACCCCACGCTGCTGTGGGAAGCGCCGAGACTGGGGCTGGACACGGCCCAGGCCTGGAGCTGCTGAGCCTGCTGGGCGCACTACTGGCCCTGGGGCCCTGCTGCTGAGCCCACTGCGTCACCCCGTCGTCTACCTGCTGCTGTGGGCTGCCTACCTTTCGGCCTGCCAGGGACTCCCTGCTGCTAGAGACTGGCTTCCTGGCCGTGCTGGTGGCCCCGCTGAGGCCAGCCTCCCACCGCAAGCAGGCCCCCAGGGCGGGCGGCAGGGCCCTGCCCATGAAGACCTCCCTTCTGGCTAGTGCGCTGGCTGCTGTTCCGCCTCATGTTCGCCTCAGGCGTGGTCAAGCTGACCAGTCGCTGCCCGCGTGGTGGGGCTCACTGCCCTCACCTACACTACGAGACCAGTGCCTGCCCACGCCCGCCGCCTGGTTCGCACACCACCTGCCTGTCTGGCTCCACAAGCTCAGCGTGGTGGCCACCTTCCTAATCGAGATCGCCGTGCCGCCCCTGTTCTTCGCCCCCATTCGACGCCTGCGTTTGGCTGCCTTCTACTCGCAGGTGCTGCTGCAGGTCCTGATTATCATCACTGGCAACTACAACTTCTTCAACCTGATGACGCTGGTGCTCACCACTGCGCTGCTAGACGACCAGCACCTGGCTGCTGAGCCTGGCCATGGCAGCCGCAAGAAGACGACCACCTCCTGGCCCAAGGCCCTGCTGGCCACACTGTCGCTGCTGCTGGAACTAGCCGTTTACGGGCTTCTAGCCTATGGCACTGTGCACTACTTTGGCTTGGAGGTTGACTGGCAGCAGCGCACCATCCACTCCAGAACCAGTGGACCCAGGTGCGGGGCTGGCTACGGAAGTTCAGTGCTGCAGTCAAACTGTCCCTTGTGAGCACTGCGACTGTGGCCTTGTTCTTGATCAGCCTGGTGCCGTACTCCTACGTGGAGCCCGGGACCACGGCGCCTCTGGACTGGGCCCACCGCTGTTTGGCGCCGTGGAGCACCTGCAGCTGGCCAACTCCTACGGCTCTTCCGCCGCATGACCGGGCTTGGTGGGCGGCCTGAGGTGGTGCTGGAGGGCAGCTACGATGGCCACACTGGATGGAGATCGAGTTCATGTACAAGCCTGGGAACCTGAGCCGCCTCCCCAGTTGTGGTGCCCACCAACCACGCCTGGATTGGCAAATGTGGTTTGCAGCCCTGGCCCGCACACGCACAGCCCGTGGTTCACAAGCCTGGTCTTGCGCCTGCTGCAGGGCAAGGAGCCAGTGATCCGCCTCATCCAGAGTCAAGTGGCCAGGTATCCCTTCCCAAGCAGCCGCCCACCTACGTCCGAGCCAGCGCTACAAGTACTGGTTCTCCCAGCCTGGAGAGCAAGGCCAGTGGTGGCGGCGCCAGTGGTGGAGGAGTTCTTCCCACCGTGTCCCTGGGAGACCGACGCTGGAGACACTGCTCAGGCAGTTTGGGCTGCAGGACAAGAGCCCACCCCGGGCCCGCAGTGCCAACAGCACTCTGGCCAGGCCCTCCACTGGACTCGCACTCAGCTGTCTCCTCTGGAGGCCCCGCCCTGCTCTGGGGCTCCTCGTGCCATAGGGGCTGTCAGAGTTGTGCAGGCCCTGCTAGCACCCTGGTCTCTCCGGTCCTCCCCCTGGCACCAGCCAGCGGGAGAAGCGCAGGCAGCCCCCATAAAGACTCTGGAGCTGCCTCCGAACAGGCCACCCAGCCCCCAACCCTGTACCAGTAGTTCTCGGACCGCCCGGCGAAAGAAGTAGCTGTTTCTCCCGGCCGCGCATCCTGAGAGGTTGGGTCCCTGGGACTGCTCTGGCCTCCGGCAGGACAGGACCCAGCACTGTGCCTTAGCTGACCTGCAGGCCGGGCACAGGTTGGGGCTGCCCCTGGGTTTGCAGGGTGCTGCATTGAGGGCTCCAGGCCCACCCCACGCCAGCCACGCCCCTCCCAGGACTCCACTGTTGCTCTGTGATTGGCCAGGAGGGAAACACGACCAGCTCAAGACCCCTGGGCTGTGGGGTCTGAGTCTGGAACCCCCACCCAGGCCCATGCCGGAGGGAAGAGGCTGACTCTCAGGGAAAGAGGGAAGCACCGTCATCTTCCACGTCATCTTCACACCAGCCATCCTGCCCTTTAGATCTGGGCACCAATAAAGGAGTCTTTTGT + E?BIJ/EE@>GICJI1@9DIG?@8EG%IIIEI3>HA+AHIJ1E=GDB'><6*IDH6HBJFJ4D:;F4?K/:=IAKIJKKJIJHI3IK&K3KHJJHH,J'EIHHK)9?HKCJHKCIFCK5E;KGJHDIDEKHB2&CFCG0JK3HI/KAJ@DH&JJKJHEJIKKKG:JFBEHH$IJHEJCGCHA@K4KGGKGK>I>CCIHCIK4GCG2?HHBF2EI+?@3@@J(FHDGK7KIJGFJHGJKH2IJJJHDJ9D&KK9KFGIJK5AKKEKKJK(>JFGIAKK8HIIFGE?8CFAGDJCC>#CHKBGJJIKJE8JI8FIJ>CJKHEK>?FKFJEKIFGKKJKJGFIHBDGBGHJJJJJ:JKKJKKGJJKE><=+JJJKFJGHEIEIGEK4HK3=GIJKH4B:GKEJG3C'EJFHACABJ@@FAEB6CKJKJJFGJGJFHDIKHK@HJHJH.JKHGIJJ?IFEE1II&JAJCKDJKKJ8KHKGKI8BDJGGH0GH?GB*GK'KJ'K?K.KK-JHDJK+I%B6DBGK>FJB8HJJKJFI0IEJKJEKBIKJGI@KK?1K=DF5>G>DJJKAKH@EJBJGGBDEHHI7E:DK@GBFA=KDIJGKK:I?:HEHIJJHC9FJC:DBHHBEAJIJ7HGFK>FKJDHC4KCE8KK4JDKEHIHJKJD6>K>B@A8IJAJIKHFKKIFJHIGIKFIB;BEEEJFE;GGEEFCAEG?D7HKEJ8KK:JJGJHDJ8IKGFCF/IAIG?BCIIH>DD*DFKKAJI)JI*HGK&HGI;JDHK8JHGDH$&K*IBBG+GIHI4B@IJDCJHKECGKHGDJHFEEJJJ%CBH@E+FC3ICFGKIICKJ92GCECF@?7CI0KIGCHJ?HKI.>I'7I8ICGJHFGFJIIJIK:DEB*J+HGKJC>J(AG4FCK?KE:F6EJCFJEBCH-JKKI9CGK/GFEHKFD>DK9CF;IHJ>39/=;J=9HK.G2C92DC=?3,H1EJ%?BHIB=HAHHF6BGBEHJCFF*HHCI$GJIKBEDGE?7>H:I=E5I::IAF56?F$?DCJKH6CE<.IGED*?IKGHIH2IDEJIBGGF?C:=3J@HII8II)E>GGFK2FJI:5J=KJ3@A@B%FJ&A?$>@F?CDJ?JAH=DJC>HCCE7D'IKGJF:FJF>GA;JIHHBJHCHIHKCB>&HGI-FAG.DIJGJGIHK:=8E>E:B9+=>EHFIED2HH(IHAGBAEDJH-BI2FA@AGC/G=CB(AIGGF)BB7HEG5JHHCGJFGD(;A@('DGHHJ9*?BCFAG44EJH6HDAJB@J=:DDBBH7DI@GJ?JAF48+5DE*FDKKKK6KCJE2IEKB9H@D:KKCHDCDAIJJB:JJ'BEEI4D9G>G>FE6AB?FDC;HG6>1HI7;H?5JGCC%03DK*JGHCB2F=;9E&AGIIKI)CFG*;F2IF>@G*GB@%=C6AB?>';CGEC@7C?D,H5HD4C&.C?'>B%JI'DAAD&C)>KJ+=:JHIAICH7+A99C?HHACGBDJHCKI7,C$EJJ8EBKJ/KK>BJIDBBKK29BJ8B:EHI5B*B/FEIKK;GA @rCer/87/1951_56_CCS ATGGGTACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCGCTCGAGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGTGTGCACTCCCCAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCAGCTGGCCAACTTCCAGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGTGCACCCTGCCAGCCACCCGGAGCTGCATCTGTTCTTGGAGCATGTGGATGGTTTTGACAGTGTGGATGACGAGTCCAAGCCTGAGAACCATGTCTTCAACCTGGAGAGCCCCTGCCTGAGGCGTGGGTGGAGGAGGACAACCCACCTATGCCTACTACCTGTACTACACCTTTGCAACATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGCTTCCACACGTTTGTGCTGAGGCCACACTGTGGGAGGCTGGACCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAACATTTCCCATGGGCTGCTTCTGCGCAAGGCCCCTGTCCTGCAGTACCTGTACTACCTGGCCCAGATTGGCATCGCCATGTCCCGCTCAGCAACAACAGCCTCTTCCTCAGCTACCACCGGAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCCCCTGCAGTTCCACTTCACCAAGGAGCGCTGATGGAGGAATACAGCATCGCCACCCAGGTGTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCGCAACAGCGTGCTCATGAGTGGCTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCTGAAGGAATGACATCCGCCGGACCAACGTGCCAGACATCCGCGTGGGCTACCGCTACGAGACCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCATTCCGGAGGAGGCGGTATCACCATGAGCCCAGGCCTCAGTGAGCCTGGTCCATGAAGTGCCACCACATCGCAGCACTTTTACCACGTTTTGTCCTCAGACCCCTCCCATGCTGTGTGGTCTCTGCATGTCTCCGTTCTTGTCTGTCTGTGTCTTGCATGTCTCCGACCATGTCACTGTCCTGAGCCGCCCAGTGAAAGCAAAGCCTGGAATCTGCTCGTTGTTGTTTGGGCTCAGGTAGCACCTGACGGCCCAGGTATTGAGGGTCCCCCCTGCTGGTGGCCCTGTCCTGGGGTCCTCAGAAGCCTGACTGTCCTACGGGCTTCTCCAGTGTCCATAGGGGCTTGGGATGGTTGTGGGGGCTGGCCCTCTAGCCTTTCAGGTCCTTCCTGGACAAATCTAAGCCTTGGCCAGGCTGGAGTTTAGGCCCTGTCTTGTTCATGTAACCGAGGGTAGGCGGGGACCTGTACACCTCTGCTGTGGGCACGGGGCTGCTGAGGTCTGTGGAACTCCAGCAGCTCCGCACTGGCTAGAGCTGGGCTGAGAGCTCAGTCACAGCCCTGGGCTTCCTGCCTAAGTGGGTAGACGCAGGTGCAGAGGTGCTGGACACATCTCCGCCAAGTCACTGCCCAGCAGCCTTCTCCGTCCTGTCCCAGCCCACGTGCTCCTTGGGTGTCAGCTTCCTGTGCCTCTGTGGGAGAGGCAGCTGCCGTGTGTTATGTCTGGGGCACGGTCACTGCAAGTCCTGGATCTGCCACTCAACCTGGAGTGGTGTTCCAGTGTGGCTCCCAGAGCTTTGACCAGATCCTGATCCAGCTGGCCCTGTGTTGTGTTCTGGACCGAGGCCTTTGCTGTGAACTGCAGTGTTCATACGACCCATCTTCCTAGTGCATGAGAAATAAGATTATTT + =GKK+JGKCCGKF@KJJHKGH?DIHEGDDHKJKKKKKIFK)KKFKKJBK&EKJ=JJJH(DGKJJKKKIKKKKKKKK%KBKKKKGJG8KHKKKJKKKJKKKK:KIFDKKKKKKK;KKKKKKKKK>KEKKK%FH,IKKK>KJKJKJJKI.KJ;K1KHIK&KCKIGIKDKGK'HK9KCK*IKIICAHKE;HK?EFK9KHKDKJK(FGGJKKKKJKAK0JKIKKKJGAE9@KKIA6K7JIK,KEKJJAKFKFKKJJDHKBKDHKDKKKIK8I?KBKKKDKKKKKJKKKJJFK'KKBKKKKKJKGKKK;EKKKKFKGI@>CE1AKKIJFKK&JK,KK$JKDK6KHK>KKKKEKKKJIK)KKKEKJDB'DJ,JCKKJJJKCKHDKIHJ@IKGKKKKII4DJJKJGFKDK6:JJIF@KKFKK6GJK?K9IFJIK>JJKKKIKHJK4I<=J>DJJ;DHK)GKK>EK>E2JHKFJ:K6IHIDKKJGH>K:KKKKKJKJKHHEIGIH?:EFK2EK=JIJKGIHK/K5FKH:KKHK8>JKAIHEK%KKK?K'EKHHAJJKJKKFKFKJ8CKKDKHKEHKKJKAGKJK=KJK@AKHHKKK9KFJI-IKADI6JGHKKK?DKKK>KK1IK,.+BKAGBKIIKHJK7HK>IGCBK6KKKIJBGDJIJ@J4JGKKKHK@JAK,IKKGJ%@KK&B;IIKKCKKKK4JK>HK5@BKJ?K?FHKH7IK9KKKGKK9;@JHI/KCJKKK9KKKIKGKKDKK%CFK2KJKK6JKKKKK%FJIHK7BE.KH,IKKK:HKKK,IJ)EK9DK7>KHJKKKJKBI0@JJKKCGK>8EK0FIK?AK8KHHKKK.=KEKI&IKKJKHKJKKJK:KHF2KK2HJK?HK*KKDJIJ:KK3K=C9FK9JKKKEKKKKG=K=K@K'K9IK+JJIB=*KJ?JJ+KH$FKKJJJ%IKJJKKBKHKKKIHCIJIKKKKBK6@%7@JK?=IJI9FKKKH@=?JAH+KI:CI-H7KBK9D'BFGIJKG:KKGK32HKEDIJKK2KJKG=KFJBKJKKK9K,)JAKDJ'GKJKJK9:FKK2IIIJKJKEJGH,J8JB;*EGHJK+AF@<@.KK3:EIDK4:8;I)HIK4FK;KKK1KGKKAKK>KK=KJKKKIJAI6K'FIK7KKKI=&FGEK$)*JI4HGJJHKJEK>0)K&HKKHCKK+ @rCer/88/2593_56_CCS ATGGGGGCCGGAACCACCATGTGCACCTCTATCCATGGTCATCCTTGATGGAGCGGAAGGCAGTTTTGACATCAAGCTTCCGGAAACAAAGGCTTGCCAGCTCATGGCCACGGCCACACTCAAGAGGAACTCTGGCACCTGCCTGTTTGTGGCCGTGAAACGGCTGATCCTTTGCTATGAGATCCAGAGAACGAAGCCATTCCACAGAAAGTTCAATGAGATTGTGGCTCCCGGCAGCGTGCAGTGCCTGGCGGTGCTCAGGGACAGGCTCTGTGTGGGCTACCCCTCGGGGTTCTGCCTGCTGAGCATCCAGGGGACGGGCAGCCTCTAAACCTGGTAAATCCCAATGACCCCTCGCTTGCGTTCCTCTCACAACAGTCTTTTGATGCCCTTTGTGCTGTGGAGCTCGAAAGCGAGGAGTACCTGCTTTGCTTCAGCCACATGGGACTGTACGTGGACCCGCAAGGCCGGAGGGCACGCGCGCAGGAGCTCAGTGGCCTGCGGCTCCTGTCGCCTGTAGTTGCAGCCCCACCACGTCACGGTGTACAGCGAGTATGGCGTGGACGTCTTTGATGTGCGCACCATGGAGTGGGTGCAGGACCATCGGCCTGCGCAGGATAAGGCCCCTGAACTCTGAGGCACCCTGAACCTCCTCAACTGTGAGCCTCCACGCTTGATCTACTTCAAGAGCAAGTTCTCGGGAGCGGTTCTCAACGTGCCGGACACCTCCGACAACAGCAAGAAGCAGATGCTGCGCACCAGGAGCAAAAGCGGTTCGTCTTCAAGGTCCCGGAGGAAGAGAGACTTGCAGCAGAGGCGAGAGTGCTTAGAGACCCAGAATGAGATCCAAAATGATATCCAACCCAACCAACTTCAACCACGTGGCTCACATGGGCCCAGGCGACGGCATGCAGGTGCTCCATGACCTGCCTCTGAGTGCTGTGCCCCCTCCCAGGAGGAAAGGCCGGCCCCGCTCCCACCAACCTGGCTCGCCAGCCTCCGTCCCGGAACAGCCCTACATCTCGTGGCCCTCATCAGGTGGATCGGAGCCTGGTGTGACCGTGCCTCTGAGAAGTATGTCCGATCCAGACCAGGACTTTGACAAAGAGCCTGATTCGGACTCCACCAAACACTCAACTCCATCGAACAGCTCCAACCCCAGCGGCCCACCGAGCCCAACTCCCCCACAGGAGCCAGCTCCCCCTCGAAGGCCTGGAGCAGCCCGGCCTGTGACACCTGAAGCCGCCAGCTCGCCGCAGGGCCCGGGAGCTGGGGATGGCCTCCAGCATCAGTGCCAAGACTGAGCGGGCCCTCCAGTGTTGTCAAGGAAATGTAGAATCACTTTGTAGATATGGAGATGAAGAAGACAAATCTTTATTATAATATTGATCCGTTTTATGCCCGCATTGTTCGTGGCAGTAGACCCCATCTGTTCGTCTGCACAGCTATGAGGCGACACTGTCCGTCTGCCATGAAGGACCCCCATACAGCCTCTCTCCCACCCCTGACAACCCGAGAAGCATGTGGGGCCCTGCCAACGCCACTTCCTCAGCAGAAACCCGTCATGACGCGGCTGCTTCGGAAGCAGACGTCTGGGGACACAGCCTCAGTACCAGTCTTTTCCCTAGTTCCTGAAACTTCCCTAGGACCTTAGGAGAATAGTAGGAGGTCATATAGCATTCCCAGTGTCACTTAGAATTTTGAGACAGAGGAAAGTGGAGGTTAGTTTGTGGCCTTTTTTTCACTTAGCCATCGCAGTCAGCTGCAGAAGTCCTGTGACCACCTAGTCATGGCCAGAGCCCGGGACCAGTGACACCCTGCGTCCCGGTGTGCGTTCAGTTCATTCTGGTCGCAGCCATGAAGTGTCACCAGTATCTCCTACTGTGAAGTCAGCTGTGCTCTCTGCTTTCCACTCGCTTCCACGGCTTCGCCTCCTGCATAAAACCAGCGAGTGTCGTGGTGCAGGCAGGCCCTGTGGCCTGCTGGGCTGAGAGGAGCCAGAGCCCCAGGCGCCATGAAGCAGCCACTGGAACACCCCCGCCGCCCCCCACCCACCAGTCCTGCCCCTGCATGGAGCCCCTGTGGTTAGTAGCCCGTATGATCACGTAGACCCACCCAACACACTCCTGCCACACTGGCCCCAGCCCACGGCGCGGCAATGCCCTGCCGGGGATTCACCTCACCCTTCTCGTACCAGATGTTGAGTGACCAGCTCTGTGGCCCTGTGTCGCCAGAGGCTGTGATTAACTGTGGCGGCAGACACAGCTGTCCACAGCTTGGGCCAGGCTTCCCCTGTCCTCCCACCGGTCGGCTGCTGGCAAGGCTGTTCAGGACGTCACTTCTCCAAGTCAGCACTGAGTGGCCAGCAACCGCCTAGCCCTTGCACCCCACTGCCTCCTGGGCCTTCTGCTGGATGGGCACCTGGAGGTTCTGGTTTTACTTTTTTAATGTAAGTCTGAGTCTTTGTAATTATTGAATCGTGAGAACATTTTTGAACATTTACCTGTCAATAAAGCAGAAGACGGCAGTTTTAAAGC + 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@rCer/89/1719_63_CCS ATGGGGTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTTC + 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@rCer/90/25_1970_CCS ATGGGGCGGAGGGAGGACTCAGGCCCGGCTTGTAGCTGGCTCTGTACCCGGTCGGTCGGTGGCGCGTCTGTTGGGTCCGCGCGTCCGGGCAGCCGCCTTGCCCTCGCCATGGCGCCCTGGCTGCAGCTGCTGTCGTTGCTGGGGCTGCTCCCGGGCGCAGTGGCCGCCCCCGCCCAGCCCCAAGCCGCCAGCTTTCAGGCCTGGGGACCGCCGTCCCCGGAGCTGCTGGCGCCCCACCCGCTTCGCGCTGGACATGTTCAATCGCGGCCGGGCTGCGGGACGCGGGCCGTGCTGGGCCTTGTGCGCGGCCGCGGCCGCCGGGCGGCCAGGGTTCGCTGTACTCCCTGGAGGCGACCTGGAGAGCCACCCTGCAACGACCCACGGTGTGCCGGCTCCCGCGTCCAGAAAACCCTGCTCTGCAAGCTTCGAAGTTCTGGATGAACTTGGAAAACACGTGCTGCTGCGGAAGGACTGTGGCCCGGTGGACACCAAGGTTCCAGACAGCAGAAATGAGACTTTCAGCTCAGTCCTTTCCCTGTTGAATGAGGATCCCCTGCCCCAGGACTTGCCTGTGAAGATGGCTTCAATCTTCAAGAACTTTGTCATTACGTATAACCGGACATATGAGTCAAAGGAAGAAGCCCGGTGGCGCCTGTCCGTCTTTGTCAATAACATGGTGCGAGCACAGAAGATCCAGGCCTTGGACCGTGGCACAGCTCAGTATGGAGTCACCAAGTTCAGTGATCTCACAGAGGAGTAGTTCCGTACCATCTACCTGAATCCCCTCCTGAGAGAAGAGCCTGGCAACAAGATGAAGCAAGCCAAGTCTGTGGGTGACCTCGCCCCACCTGAATGGGACTGGAGGAGTAAGGGGGCTGTCACAAAAGTCAAGGACCAGGGCATGTGTGGCTCCTGCTGGGCCTTCTCAGTCACAGGCAACGTGGAGGGCCAGTGGTTTCTGAACCAGGGGACCCTACTTCTCCTCTCTGAACAGGAGCTCTTTGGACTGTGACAAGATGGACAAGGCCTGCATGGGCGGCTTGCCTCCAACGCCTACTCGGCCATAAAGAATTTGGGAGGGCTGGAGACAGAGGATGACTACAGCTACCGGGGCCACATGCAGGCCTGCAACTTCTCAGCAGAGAAGGCCAAGGTCTACATCAATGACTCCGTGGAGCTGAGCCAGAATGAGCAGAAGCTGGCGGCCTGGCTGGCCAAGAAAGGCCCAATCTCCGTGGCCATCAATGCCTTTGGCATGCAGTTTTACCGCCATGGGATCTCCCGCCCTCTCCGGCCCCTCTGCAGCCCTTGGCTCATCGACCATTGCGGTGTTGCTTGTGGGCTATGGCAACCGCTCTGACATTCCCTTCTGGGCCATCAAGAAACAGCTGGGGCACTGACTGGGGTGAGAAGGGTTACTACTACTTGCATCGCGGGTCTGGGGCCTGTGGTGTGAACACCATGGCCAGCTCGGCGGTGGTGGACTGAGGAGGGGCCCCCGCTCAGGACCTGGTGCTGATCAGAGCGGCCGCTGCTGCAGCCTGACGTTGTCCAGGCCCCTCCCGGGAGGTACAGCTGGCAGAGGACAGGCACTGGGTACCTCAGGGTGAGCAGAGGGCACTGGGCTGGGGCACAGCCCCTGCTTCCCTGCACCCCACTCCCACCCTGAAGTTCTGCACCTGCACCTTTGTTGAATTGTGGTAGCTTAGGAGGATCTTGGGTGAAGGGTGGTATCTTGGCAGTTGAAGCTGGGGCAAGAACTCTGGGCTCGGGTAATGAGCAGGAAGAAAATGTTCTGATCTTAAGCCCAGCTCTGTCCTGCCTCCGCTTTCCTCTATTTGATACTATACATTTTCTGGTTCCCTTGGATTTAGGGATCGTGTCCCTCTCCACGTCCAGGAAACTTGTAACCAACCTTTTCTAACAGCAATAAAGATGTGTCCTG 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@rCer/97/1094_55_CCS ATGGATTAACCCACTAGCTCAACCCATTATCTACACCACAATAATCATAGGCACACTTATCACAACACTAAGCTCGCATTGATTCCTCGCCTGAACAGGTCTAGAAATAAACATACTAGCCTTCATTCCAATCTTAATAAAAAAAACAAGTCTCCGCTCTACAGAAGCTGCTACCAAATACTTCCTGATACAATCTACCGCATCCATAATCCTCATAATAGCAATCATCTCCAACAACCTACTATCAGGATGCTGAACAACAACGAACTACATCAGCCAACCCCCATCCCTAATAATAACAACCGCCCTCGCCATAAAGCTAGGAATAGCCCCCTTCCACTTCTGAATCCCAGAAGTTACCCAAGGAACACCCCTAACCTCCGGCCTACTCCTCCTTACATGACAAAAACTAGCCCCCATCTCAATCATGTACCAAATTCACCCATCAATCAACACCCACATCCTCCTAACCCTCTCCACCCTGTCCGTTGCAGTAGGCAGTTGAGGAGGTCTAAACCAAACACAACTACGCAAAATCCTGGGGTACTCTTCAATCACACATATGGGTTGAATAATAATAACACTAGTATACAACCCAACAACTACAATTCTCTATTTAACTATATACATTATCCTAACAACTACCATATTCCTGACTCTTAACTTAAGCTCAAGCACCACAACCCTTATACTAGCCCGCACCTGAAACAAATCAACCCACCTAGCACCACTAATAGCACCCATTCTCATATCTCTAGGAGGCCTACCCCCCTAACCGGTTTCCTACCTAAATGAATTATCATCCAAGAACTCACAATGAACAACAACTTCCTCATCCCCTCTATTATAACCATCATAACCCTACTTAATCTATACTTTTATATACGCCTAATCTACACCACCTCCCTAACGCTATTCCCTACATCCAACAACACAAAAATAACATGACAACTCGAAATACAAAACCCACACCCTTATCCCCCCACTCATCATCATCTCTACTCTTCTACTACCAATCTCCCCCTACTCTTAACCTTTC + KKK3KKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKJKKKBKKKKKKKKKHKKKKKKBKKKKKKKKKKKKJKKKKKKKKFKKKKKHKKKKKKKKKKKKIKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKAKKKKKKKKKKKKKKDIKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK6KKKKKK6KKKKJKKFKKJKKKKKKKKKKKEKKKKKKKKKAKKHKK?KJKKKKKKKHKHKIKKKGKKKKKKKK-KKKJKKKKKK2KJKHKKKJKKKEKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK1KKKKKKKK,KKKKKKGKKKGKKKKKKK=KKKKKKKKKKK?KKK>KKKKIKKKKKJKKKKKKKKJKKKKFKKKCKKKKKKKJKKKKKKKKKKKKKKKKKKKHKKKKK4K.KKCKKKKKKKKKKKKKK-KKKIGKK&KKKKKKKKK6KKJKKKKKKKKKIKDKKKKKAKKKKK5KKKKKKKKKKKKKKK?KKKKJKKKKKKKKKDKKKKK=KKKKKKKKKKJKCJJKKKKJKKIKKKK?KKKKCKKKKKKIKKKKKKKKKKKKKKKKKKKKKJKKIKKJJDKKKKKKKKKKKKKKKKKKK3KKK9KKKKKK=KKHKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKJKDEKKKKKKKKKKKKKKK9KKJKKKKKKFKKKKKKKKKKKKKKKCKKKKJKKKKKKK7HKJKKKKKKKKKKKKKK(IKKKKK9KK0KKKKK*KKKKKKKKK'KHKKKKDFGIHKKKKKKKJKKDHKKKKKKKK3KK;KKKK+KKKIKKKKJKKKKKK @rCer/98/1843_61_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCCAGATCATGTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTAACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCACACCATTGGCAACGAGCGGTTCCGCTGCCTGAGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCTTGCCCTCCTAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCAC + 7/997003+073.0*03*4663843566+550779288:79=;95==887*:?:<7/418=.5;=7><7==//99348545)751<:9;6=>;<656:;264/8<==6<=>=:896764<;>67/84950.61766<2?996)7>2:;78;/>98=<720:;:>=09<0?8868:/89<*=:62;80)::8&+29=:/8?999<;9:;56623127337:-433793:800)0-782-43743656)734254;-881'5965948346;8346.151/1.%.86/2028*215667,76/3:,02'24:771/9/*592*/03799.,'21,)*+.47;:81/+.1-5093/.033*7831/.1.52545+14:65732685++556.552134)%64266.854789/)1771046,74;800854061,'*0000284363)*,*.3103+#5419;:;4(53/6944.526377986112731.0+/-4458558:457882'--1,955+,47;58.8.83-&/1673//*3.5246211)121*1./0544+44/11*,*(++30210%+(,.-,20/31)004/01&/1-/2'.1040.-0*'-.-04.4.340-3--/624-//(451/5/23//0533&02.05534501+356/0/*-/*'0,/,/%+2314,51...5)345+42-3(22,*+5-/-10-/512/55602./'+*1'+/).-14124525141+,11536/.-)0)1/--(+,5222)12+23+/546214515/+21(-105551/1315(20')35-03,1,46+4.54021$,'3.*.(2,14*/,&034,/.2..1.)3-)($$+*--)+#1,-*2-2++)'&2'0.1'1123.33162+0,2-',20*//20612/2416234)*0/%1,,1/40.444'/)/.,5.0,1-645.00*416110,/.46061252)3535+0/1)3,10)223-.31404''14'52062/+2642/51,$,-0/(5613/1*'3%/203/+()..0/04-0531401+%6,4414402.21'2354,0-/4//2542,56/311-')10.52410543+5643/4*-041.4.2).1315455.1652/23214*2/4120)*56/544+)4*40+2210405431/--0-6646355014/24+-642454*345644556462//.*31,01.*555.,.25.)2.,0&2-)465512012*31350-3(1444-.412*45,/133/0-0,4--**0*564/5-0+(661265,3454+4456)2,0.1201/1$4/03-//+')21)1/613435*/13-0%024403)2,0355645/,021..'0/1*005/3*)24560-.%34./,(+3345/63203-604312)211+54441-&13*/1034130&1'352,4-/,1,04,/1-,+0152-/3-23/5412-/%%*0$''/46-/3)$/0%24)5&.6/51/00.55004*+,,560+4/23)3522.02..1'50046/15041414-362.52*'--*446323-530&/1-'3+53146(*)/1.,#.24463(/,-.3+304,/.62.422420$(/45*5325.1-12$02012+.141312)2.,/2564*-20212%555422(,'$4,,053250,,01)4(312)204/-3600263+4420'+/1+5,4.26111-)-$/6/02534,+2210/'.44065143(34+0.22'5343.. @rCer/100/25_1556_CCS ATGGGGTGTTGCGTCACGGTGGGCGGAAGTCGCGGCCGCTGTTTTGAAATCGGGCCGCGGGGGTCTCTCAAGCTGGTTCCAACTCTGAGGCCCCACAGCCTCCCAATTCCGGGCGGACCCCTGACGGGCCTGAAGCTGCAGCCGCGCCATGTCCACACCTCCGTTGGCCGCGTCGGGGATGGCGCCCGGGCCCTTCGCCGGGCCCCAGGCCAGCAGGCCGCCCGGGAGGTCAACACGGCGTCGCTGTGCCGCATCGGGCAGGAGACGGTGCAGGACATCGTGTACCGCACCATGGAGATCTTCCAGCTCCTGAGGAACATGCAGCTGCCAAATGGTGTCACTTACCACACTGGAACATATCAAGACCGGTTAACAAAGCTACAGGATAATCTTCGCCAACTTTCAGTTCTCTTCAGGAAGCTGAGATTGGTATATGACAAATGCAATGAAAACTGTGGTGGGATGGATCCCATTCCAGTCGAGCAACTTATTCCATATGTGGAAGAAGATGGCTCAAAGAATGATGATCGGGCTGGCCCACCTCGTTTTGCTAGTGAAGAGAGGCGAGAAATTGCTGAAGTAAATAAAAAACTCAAACAGAAGAATCAACAGCTGAAGCAAATTATGGATCAATTACGAAATCTCATCTGGGATATAAATGCCATGTTGGCAATGAGGAACTAAGCTGATATTTAAATTTCCTGCTTTACACATGTTATACCGTTGTTTTTTCCCTCAAGTATTTTTTTCCCTGTGAAGAAGGTTATTTATCTGCTTTTATTTTAGTCACTAAAACTAAAGTTTGTATTTTTACATTGTGATTTTTACTTAAAATATTCATTAACTTTTTTTAATGCTATTGATCTTATGAAAGATTATTGTAATAAATTTGATGGGGTTTGTATTTTGGTTAATCTTCATGAATTGAATAATTTTTTTTAAAGCAAAATAAAGTTTTTTAAATAAGTTTTTAAATTTGATTAATGGATTTACTCATTCCAATAAACCTTTTAGAAGAAAACTAAATATTTAAATATTTCTGCAGATAAAAGTATCAAATACAGTCAGTCTGTATACAAATTAAAATTAAAGATATGTTACCATTTCAGCTCAAGTTTTTAAATTCAATTTATTGCCAAGCCAATTAAAATGTATATTTCTATGAATAGATGAAAATTTATCTTTAACATATTCTTCAAGTGTTTGGTCTTAAATGATCTGTCTCTAAAAGGAGAGAAACTAATGATCTAAGGACAACACAAATTGAAATCACAACTGTGTGCTTATCTGCTCTGCTTTAAGCTAAGAAGCAATCACCTAATTTTTTAGGTATACCCTAAAATAATCATAAGTGTGTTTTTGGAAATAGTACATTTGTAGGGATTTTAAATGAGATACTTCTATATGACAGGTGTTTTTTTTTGTTTTTTTTGTTTTTTTGGCCTGTAGTCAATCCTGTTTAGGTCTCCCTGTGGGAGCTGATCTCTCATATTACAAATAATATATTCTCAAATAAAGAGTTGAAGTCTTC + KK'K??F@3KKKKKKKKJKK6EIKKK:KK+JKIKJKEK4KK5KKKKKG$@JCJK9K2KE,KK>HKK4IKKGKHKKFHGGIGKKJKEKKKKKKKKCKKKKFKDIKD=KKKK>CHJKFDKKKKGKFKGKJKKKKKKJJJKK@K1FFJKI>KKKKKKEKABGKJKJKIIKK4CKH?KHGGKJJF<>DICKHJGKKKJKBKK7KKKKJGKKKKAKKKFK>KKKJKKKJFKKKKGJHBKGG8KKKKKGJGK=KKDK>KHKK,JKCKKKKAKJHKKKDAG(5@CCIHK=IK'KKKKK5FKJK;KKKK'KKKIIK(IGHKDJJKK:KIKDKKBKKKKKKKI-FHJICKKKKKKKKKI3KKFGD=HKK%JJKKKAFKKIJKKBJIFEF6JKHKKK?K+G8EF?%JJJIEIKK'IHKKKK6?EKKJKJK:KKKFJKCHDKKKF=EC2E&%KKKKK7KKK>JGJDIEKKJ4IHKEKHK>JHJKHCK7GKJKKAK&E=8KKKKKKKKGKK,KKKK?KKKKKIJ+FKD5IKJKGKK7KBK/I?KKKKKBIJAKKJKHKKK?KKKKHKKIKK0KKK0KJKKJJJHJKKHJJKK4KKK>KDEJC1IFJJBJCKKKJKKBIKJKJHKKKHKK2KKEKKJKJI7KKKKHJGJHHKGHHKKJJKKKK8KKJKKKK.D@7HJJKKIKFJKIGK9IKKJKIKJIDJ3GJKKEKKKJ8JGKJKFKJEJKK%KIKKKKAKKIJKB5HH?KKEIK5KKG4KKK8FFKKKAIKKJFFKGKHIHKKKKJKKK+IFGKKKIF;1KKKKKKKI5KKKKKKKKGKKKKIKKGGKEGKKKJKKK7KIEK2HKKHJ3KKKKCIKKKKKKHKKGJIKJKJKKKBJJDEC?DHIK6KKI:KKKKHIKG6KHIFDKJ @rCer/102/20_2386_CCS ATGGGGGTAGGAGGAGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCCACCGGTCTCTAGGTGTGCAGCTTTGGCTGGTGTCATCGCCGTCACTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCGCCGAAGCCATTTCCAGCGACTCGTCGCACCCTTTTCTATCTACTTCGTTCCCCGCCAACCGCAACCATTGACGCTATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGATCGAGGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCGGGGCCCTTATCTGGAAAGAAGTTTGGAAACCCTGGGGAGAAACTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCAAGTTTGAGAAGAATTTCTATCAAGAGCACCCTGATTTGGCTAGGCGGACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAAATTTTTATGAAGCTAATTTCCCTGCAAATGTCATGGATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGATGGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGAGTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCCACATCAATCATCAGCCATTCCTAGAGAGAGGCGATGGGCCCATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTATGGTGGTGCTCCCAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACTCCTGGAAGAACTGATTGACTTTTTAGAGTGTGGGAAAACCAATCTGAGAAGAACAACCTATCTTGTCCTTGATGAAGCAGACAGAATGCTTGATATGGGTTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTCTTGAAAGACTATATCCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTTTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAAACTGCTCGCAGTACCAAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGGTCGTTCCAGGGTAGAGGAGGCATGAAGGATGACCGTCGGGACAGATACTCTGCGGGCAAAAGGGGTGGATTTAATACCTTTAGAGACAGGGAAAATTATGACAGAGGTTACTCTAGCCTGCTAAAGAGAGATTTTGGGACAAAAACTCAGAATGGTGTTTACAGTGCTGCAAATTACACTAATGGGAGCTTTGGAAGTAATTTTGTGTCTGCTGGTATACAGACCAGTTTTAGGACTGGTAATCCAACAGGGACTTACCAGAATGGTTATGATAGCACTCAGCAATACGGAAGTAATGTTCCAAATATGCACAATGGTATGAACCAACAGGCATATGCATATCCTGCTACTGCAGCCGCACCTATGATTGGTTATCCAATGCCAACAGGATATTCTCAATAAGACTTTAGAAGTATATGTAAATGTCTGTTTTTCATAATTGCTCTTTATATTGTGTGTTATCTGACAAGATAGTTATTTAAGAAACATGGGAATTGCAGAAATGACTGCAGTGCAGCAGTAATTATGGTGCACTTTTTCGCTATTTAAGTTGGATATTTCTCTACATTCCTGAAACAATTTTTAGGTTTTTTTTGTACTAGAAAATGCAGGCAGTGTTTTCACAAAAGTAAATGTACAGTGATTTGAAATACAATAAATGAAGGCAATGCATGGCCTTCCAATAAAAAATATTTGAAGAC + FA/KKKGJIBFDBHDDJIHKFBAJFD=?HGGEE0DCII;F8KCKIKBHK:GHGGKGIIKKKKE9JK8KDF7IJAGJC>JGHKK@JJIH?KJIKJDGKGKC2IJIKIIBI4ADDKIH2KJAIG@IIAKIFKIFHJ?G@HHHH7AIJGFJIDCKI5KKIIJHHH5DFCCEK=FJFI3HCK5KHEIIHJDJK=IIBJCJH8DF?IKGHKIFKD/FAHJIF?JEK/KHJBKK=FGJKK:?,@?E:GG/@5FFFAHEACD?DB@FCB=I@K2II?GII8GGIKI6KBEFI@AH=D8EH:AIDKKGIFFIJFA8F)DGGIAFG?5EI@HDJFHH:8A@I>HGFD2JD;?ABI=@(>FGI@AE?AHBFJAKBF8E@8@:@IIHIH@4?DDB3>?7;AAIJ:GAA=?IJIE5JH=EFC4C?DFFI7HIGH:AGDIIHC1B5J>K:KKKJEIA@=H2@JHIH0F?HGHEJJK.IID6EF7IH>@H4>AGGDKKGDJAIGG=1JAHHIJHH:GI;G?;HJJICH.KGAG>D3FB;GKH@JDJ?ABHIJIKDHCCGHJHKEKHJFJGG?+FFEBKHEJ@IFGHG9KCBHIF?KKCIB8I8G=>=ED@EGIBHCEI+JKK+D??HA+CBJHEH9A;KI?G-DHGFCKD<==FCE@D@JI2@GKJKG9KGKKJJFGIBEAA?F%FEH?@;@BFBHJG*KIFFC>E@>DKHJHF=HCHEEJGFH>JF@DJEGKJJF5GKHKJB@KC@ABJHGJ?JGCDE;F5EIGCBHBKIG/IFHJJCIJEBDH9FHCG<5<-KJ7DJBGGGHG9J46HJFKFIG@K>F&?6I9K?DJKIK@'DHJEKHFKGKAJF:B@HDIJFGJJK4HIEAF@FG8F2E7$CF=FGH9B=8DBGJJDHEFABAFDKFDD4EBAJA<>8CE@FD:<>@HA;HJI2IHKEEJJ@JIBKJF;;,FFID7DHH?@KE&DF@6>->FAFHEF9F4I@GHIIDEBJ>9@EFJ4I;DIEE/FDGGIEDIAFJGHIEF@IJG,HA=BJ=K0HGDIHI1DJ1C:,FE6EHDJ/@0G?D.HG:=>>=HJ?JHK?GGIDK?I:C*FDEKHCD0IICB8C>E@G?AFBIIJDG>I@B,KKIE@2GHK8KBBEJ7JI8HC,DBA?ID@H@CBECCEB?EDHBBA,DDIAEJ>BF@JH9IGDDED3;A%@B@AEFCHA.A>DEH=KBCAH>CHJJGDE$?DDFF9ACD@CCFD2FGGFFCD7DA=>GG0G;C?=>*9CGIH4KIBG<F@/FKH@GKFJG=IG.IJH@:F;HG8FDGGIAGJ?K@G:JBI8$DIKDGHF9HJF?KIH> @rCer/103/0_970_CCS TTAACGGTGCTAAAATGAAAATTCTAACCCAAGATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACTCATTAATAGTCCCATTTTTTCTCTTGCCATTTGTAGCTTGCCCATTGTCTTATTGGCACATGGGTGGACATGGATCTGCTGGGCTCTGCTTAAACACACATTGCAGCTTCAACTTTTTCTCTCTAGTATTCTGTTTGAAACTATATCACCGAGTCAGACTTTGGTTCATTTCATTTCAGGGTATTGGCTGCCTGTGGGCTTCCCAGGTGCCTGAAGTGGGCAAAGGAAGTAACAGACAACGATGTTGTCAGGATGGTTTTGGACTAGAGGCCCAGTGATGGGAGAGGTCCCTGCAGAACCCACCAACCAGAACGTGTTTGCCTGAGGCTGTCACTGAGAGAAAGATTCTAGGCTGTGTTATGAAATATAGACATTCTCACATAAGCCCAGTTCGTCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACACTAGGCTGTTTGGTTCAGACTTTTGGAGCATGGACTGTCAGTTCTCTGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAATCAGGCTCTTTCTCAGGGGCTCTGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAATAGAAAAAGTGGAGTTAGTGAATTGGTTGTTCTTTTCCCCGCATTTGACGACTGTCATAGGTTTTTAGCATGTTCCTCCTTTTCTTCATTCTCCTTTTTTTTTCTTCTATTATTAAGAGAAACTTCAAAGTTAATGGGATGTCAGATCTCACAGGCTGAGAACTCGTTCACCTCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACGAACTCTCACCCATGGTGTGAAGAGTTTCACGAATCTTTCAAAATAAAAAGTAATG + S#),+&,,--+&,*&'+',++)---)-$+(&%$&&*-,&'($$((-,(+,+--,-),,-)*-,.(,+)'--.#(,,,'(+))'$,"$)+%)-,%)''+++,))*(+()+..-,(++#&'%'*(,*,%%#$&&()-)'(''$-.,'(&)*,,-)),'+-((-+'(('*$*,(((,)('(*+-'+'&))('',$#('''#+,(&&%))+&)(%%$)*+))(("#"""#$'$((&&'(((('-,(#"$&&(-,,-,).-*')**(#+(-,)+),--'&(+'&)(**+'))#&--,$$$%%*)('+$#$'+'*--/+)))&#--.*)#)+/0'%*',/0%/0'$3154+4312&21,01612*34--3&01565/--.1)5./0.*3262611-6523&(14)+53)-+-2,+-*-)'*'&,'+54--,/+/+$4/.21+)0//,#1-,.-1025*)/42'%/01251&31./+)*,/)'#)(&+**--%++.0.+--01)*.,*/.*,//.)-.342.)3301..04*5206*/15,05+111#,*+/14&33((0()-*(00,21(6)+0*.65250%0*3*.*255-%+-.*/00'+(),2*1152)24/'005)1024$/#,-'+'-/,/*54/*-42#)(%0212//01+-.+.24--20//0*3/405*1//0+*1''++0/2+/05/-(+'%),3/)1)/2.&/,--242614/,/+//.)*.,/)01/00%-)((,..30.*/*%(3*,(-*././#$+-66420/1011+2(*''/$0.),.214-.01$+#&+.-*+..#%)//(+*#+-%5..)'$&-(33%,4+41+00&.,)$$()1210465/)+01/261)&3(0$&/5).))($'4,.1-60031-'555556641065,324102420/)0,%/'-*-,.%,.1.,//*+*-5100*455610,/..%/,2(11#&&%(-/25-4+3 @rCer/105/2202_56_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGCGTGAAGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAATTGAAATAAAACAATAAACTTTT + ;<>5*88>@@B<>:=/1<++-785=?A6AD<05-3+6.>5C5=CBE7JKH@AEDHG&AHH0<:IIHKJJGHFFKFF.IGGFCFI?A9IH5GEIDFCFH7CCI>DJ>?7?=@*9?4D9A?@:AEA&=FGH?J4G=>6CD'::8AF?=5:E=<$@B>F@*9@IBAF=F?:@B=HHGD:?FIFG(E:H@G8CBCABH?D0G1@BDAD>F;=CJKI0FA@D>C@@BECEGK-EDD@H9A7:@5G1ED>GH@I?E>F9>CBKA:EJFA4:DJKKHIF>AF>DG@+4B>F>IF>HFJJ3IIJGICIIHA/G8FIC;B'A?AFH>@B7>+FFA3K????CB+@HHHEECD+AHI8HKJKKIJKAHB47F4EGGH??4A>@+GK?>FDHE;@@4AAB@F:@EJI,JBBJEIJ2H?BB@E;?86=>BF>2*98=)23'&?>>E;=3IBIFG.2G=IHEI;??>CEKBIF+GBA8;A;@DFGA?1E6F2ID,I1HJJ.<@F(?BBA%6JAGDF@A3@9:?EFHIBDDEGH6A9BA21@=C;E9JDJFC>C7FCBEAKDAFFIFJKKB?>4DAHB1:B?GGA??=>?DFDIAIEE7E@CAA$EIKKICAEBDH5FHHJHE?GHDIB?FF>>?7AC?$53?<D@C@>DAF4DGKD:9FFC89??@9ADE<>=<2,=@5?2E7GCBDIFG?BJIDJJ6@>A;8CFHDF.AEE8?76%25?GFFBA;G?A$GKKIGCH7IHIKHG@.8>&8CC6EE=F?EE8C:?E?BHEE>7/,;BICE.DH@:15-B2=?:=@>BB7>GIIC@><>=5;9A>:?=5C;F?F;<):6A???=?051B?=FHCDIFCHGGF=><5;GFB4ECCDHGH=%03:7A.89:C@>9;'@17+27:8=G;A9FE@2=@><9CBDEAA->D8DA&?;CD=CC@78A5?A749D@4>E@>C;CHI?=EIECD8EA*C==B*;>CCE@EE9C84D$7=DIF=42:<7>DEEJ=GHAF=@=CC1:F(A?:+=CEG:B:BJ8B9>'CD@F>ADHJC?8C?498E0;G5FC0B??3>G;:?B7==CBEF6DFCID=A>;5B=FJECA8J@@6:DE4:3C9D=@'9?CG@GHA/@43C=6BH>=?81;8@A=?844B?BC?G31BC=9?B;=D,CB;6?;=@@?=/=B587.B=B/AC;7-1GA=?;(<;:==C9>CB<>6?CECFA;?C@E<;2CD;3:C7CFEEB:B;;FI;?C;04<58?<@'GCFADDG65>>.A?B*CEA42:669<>?6;0;::8(>B?E8?<=%.==/697D;E=;;0345$6?26140??9>40>ECCE7971=<310-AAD4=2>78<*<;?GDA6=:>==35<61=.@+A;G59DGC6<=CEBB;D?6)@1921=3&44==B@3)<+3B9BIC5<><8C5=77,7=DC@@?BCB:E?>C:==HI>GHADA@?8HAD>18(?EA.:67<>DA+EDEC>??8;CCEHC4:?EGIIH>>9?=@85=-B>D16=7:;CFG<>E=GAEEIDC2BA>EIF??B6A=8CGHIEIJ@CD6GFGEEH:2;DC=%8'5$131;+55:-0847?9-535%39;=;;;:66;>7<=4==9;872329>8;;=97%:5)30$7>=0/0848:60<0@<%9;=5'9=9@72-/;65=8-3=<&7:6>;>:)136::8;:A?-<<:<8A7<298C>A74?A-7::6=74;7>@:@>;8;.323009<97B<-95+><;8>677=;A+?;;79<-?>BB:=<&>:(%:5;7<9.=3<>A':295;(6=:=<=??49)8,:)?>DADA2:9@+B:2>91A5A<@>?,DB@9;B(BFEB<8>&?F>FFA<8<7@A@7?=@:1AB?EEE;*BBAA;5BA::9??=/C?:9)=6AAA0=?7@8ADEF?CF8>,????A?:CEABC=::;*=>=BAB+>CA=??6?/7?7>=:3B@?73>76@>=?BD@C>7?2>B9>.(8;:7@4>8?4?E@=58@EA4BE>/=??7;+@BF@:;:A<7;?<8>?:9-8+:7E<3A?@9BB9&::*899>66BD?@>=C6/58/1B>$9E>;8$A<?=4B;'0-4.;=E>;71:?<:?@4EE<>7:3?9D9;;A?AC:9?@BE.B*8<9>AADGFE9DD6'B):A;@14:;=D9GCA94:4998<:=@$79>><>:56'=7D@CCE@@<;9@BC;;:7=8=@0:>%::7239:7=83;8+;?378-99)43>7+5:=67>676>A>C9=@C<-:9<)837:7==@9015'84<0>81;88+28/6;1@<89:?@7@0<2<7:(0(66',%1$&1/65=?3:>@9<:@A9385:;<147)>68>B*4,48>;/2.:9C@9:6<%9:7=;:D.?A0DFF6FD?;E9>-6?BD>5=FCA1DDAF@<4>C9@?>?=73:/8>AA@D+=;A@1@>57%65&9=@:?CDB<>;=>$45001;9E=@2978;=@->CA;@E;D7=0B5E:==EB(1CFBEGF?H.D?=6DE8A?:@6D>CAED5C7E@IHBJ>D8?.8;'.'/5<,4+08872/86-4:*4(02:877CHFE6?A/;55DF98:EFACCD?4C@E@DCG>?BE;HEHFG9C5CE=(7>EGA;CDEB@%::EDB?>@H@@D@=1GG0078/EHH?IEFH=8/F>CGF?+@+IA&CDHFEH0DBEDADA647A>=*HGIFEE>DB?E?C.;HA8,5AECDAAFD>D6*@C>GGG97&D=C768/145B/AB@F@5$::11><2/CEFFE;E;FHIC;E?GBC@AGGBI@EDH5ADFEC/>*6B=HA4?C>(=?>7/E):ACHCEAA,EGC8FFHAE:E%A77>;@19880:6:.?9HEFB:;7=+0?CA5AB?:#8547/0>EC9E@B=.@397:3@8+6:;C8739:9*?B'>>?>D*B;&9/6>>6/@7*6+5)4C7%93#4(<=;4,;8)7.//9))/<<:4$9'9;=8:/@;F>D8GB:7D@FBAFFE@8B>?3DD>H:B>=?:=@<)BGC8*A=8B4GE=?/7@:A&?/39-@F=CH82$>EICE?EDJE?4ED:9=>-AC9?A@=99?@E;C*@E?=?9;BGI:8H7EA@;AGA=D>7A%A9ACD?+GC(=5.@A$514AD<@AF$;3981==@CDE8JG?I4EA/8:?DD,IA6FF,HF6CFCF8HHB4EGBEF9HADCA8-E><>)?F?8?D?9@CF>C@DEED<4GHI)CCC>:D=I5HA'EGCGC>AGGB?G;D@8B<-< @rCer/112/2177_54_CCS ATGGGGAGACGCGGAGCTGGGAAAAGGGAGGCAGAGGAGGCGGAGGCAGAGGCAGAGGCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCGAGCCCGGCGCCGAGACCAAGCGACAGACCGGCGGGCTGGGCCTCGCAGAGCCGGCTCTTCCGACACCCCAGCTGGAAAGGATAAGCGACTCCTCGCTCGCATCCCGGGAGCCGCACTCCGGGACTGGCCCGGTAGTCAGGGGCTCAAGAGCACATCCCGAGGCAGGTTTTGCTCAGCCTCCGACGAGGCTGGCCTTTTGGAAGGCGCCTTCAACAGCCGGACCAGACAGGCCACCATGACGAGAATTCCACGTCCGCCCTGCGGCCAAGCCCAAGCGGCCAAGGCCTCCAAGAAGTCCACAGACCACCCAAGTATCAGATATGATCGTGGCTGCCATCCAGGCGGAGAAGAACCGCGCTGGCTCCTCGCGCCAGTCATCCAGAAGTATATCAAGAGCCACTACAAGGTGGTGAGAACGCTGACTCGCAGATCAAGTTGTCCATCAAGCGCCTGTCACCACCGTGTCCTCAAGCAGACAAAGGGGTGGGGGCGTCGGGATCCTTCCGGCTAGCCAAGAGTGACGAGCCAAGAAGTCAGTGGCCTTCAAGAAGACCAAGAAGGAATCAAGAAGGTAGCCACGCCAAAGAAGGCATCCAAGCCCAAGAAGGCTGCCTCCAAGCCCCAACCAAGAAACCCAAAGCCACCCAGTCAGAAGGCCAAGAAGAAGCTGGCTGCCACGCCAAGAAGCCAAAAACCCAAGACTGTCAAAGCCAAGCCGGTCAAGGATCCAAAACCAAGAAGGCCAACCAGTGAACCCAAAGCAAGTCCAGTGCCAAAAGGCCGGCAAGAAGAAGTGACAATGAAGTCTTTTCTTGCAGACACCCCCCTGTCTCCTATTTTCTGTAAATACTTTTCTCCTGTTTTGTCTTGATGCTCACCACACCTTTTGCATCCTTCTGTTCTGACTTTGTAAGAGACAGGATTGGATTCTTCAGAATTACAGAATAATTCATTTTCCTTAACCAGTTGTGCAAGGACAGCAACAACCAATCTCTATAATGATGAGAGTGTACTTATATTTTGTTTGCTATTAACCTACTTACGGGTTAGGGATTTGCGGGGGTGGGGTGGGCTTGTGTTTTTGTGGTTTGTTTGCCATGAAGGTAGATGGGGTGGGGAAAGACACGAGGCAGTATGTTCGGCTAGATGAGAAGGGAACCAGAATCGTGAGGTTAGTAGGAGTATCTTTAGGTGAGTGAGCTTTCTTTGAGTTGGGCACCCGTCGCGAGAGTTTCAGAACCTTTGGCCAGGAGGAGAGAGGTGGTAGGGAGCAGCCAGCCGGCAAAGGAAGGAGGTGAAAAAAACTGCCACCGGCTGACTTCCACCTCCCAGTGGTGACAGTGGGGCCCAAACCCAGTTTCCTTCATTCTGTAGTTTGCCCTTTCGGTCTCCCTATTGTCTTAGGGAAAAGGAGTGGGTCCAAGTGACAGCTGGATGGGAGAAGCCATAGCTTTCCCAGTCACTAGGATGTAGCCATTGGAGGATCTTTGTGCTCAGCAAAATTCTCTTGTTAACGGAGTGAAACTTCAGGGGAAGGGTGGGGAGTCAGCCAAGTGCCTCAGTGTGCCCTGTTGAAACTTGATTTTTCCATGCATCGATGGATTGTGTCCTAGGAAGACTTTCTTCTGGATTTTTTGTTCTCCTGTACAAGAGTGTCTTTGCTTGGTTTGGTGGGGCTGCGGCCACTTAAAACCTCCCGATCTCTTTTATTTGAGTCTTTACTTAATAGTTGTGCTGGGGAGGGGAGGGGAGTGGCGGGCAGTGGACAGTAAGACATACTGCAGTCGATTTGGGATTGCTAAGTAGTTTTACAGAGCTAGATCTGTGTGCAGTGTGTGTATGTGTATATATACATATCTAGGGTTAGTACTTAGTTTCACGCCGGGAGCTGGGAGAAAACCTGTACAGTTGTCCTTCTCTTATTTAATAAAAAGAAAATCGCGTACTTGCGCGTCCCTCCCCCCGCTTTTAAACAAGTGTTACTTGTGCCGGAAAATTTTGCTGTCTTTAAAACTTTAAAATAATTGGAAAGG + (0110(',/0-00/-/(..,&110*/**/(()./1.+)*%,,**1,+''*,&.+/),&++',.2.+*%*1*/.+)1,*,,*/&.0+&(#&'./1(-,-0,+.++.2/0(,10./)+'+%.-,-0&.+.+$/'//-/+1/*0+2,'(*##1,+.0*/(*%+*0*+$,1/0,+*%###()-)-*1,(++/,-1/-,&((%+**))+'(,1)).%.--0*10)-'-),(/.0.,'-%00-,,%'%,**(/&.-1)-)/+-./+,%00/01,-1,,+-101')0+%.(-00,1+/,0-1/0*/%*2+,)&200--2.0+/*//--)/.(1,($#('&.(,%1-*11++&,0-)0,01+1(*%/2/0,)()-%+++&2/0*/.-2/,2/,+/&,/)$&'#()-%('#$)$.(%0-&,,-,-0,1,1-+,&(&2.00**2,0+1-%/*+(,-+,,(,.(2,,/0102--+'',)+$*).(+/,(++.1/--/,//+,/0.+/)-0$*-+,-%-0/+//),0-/-0,,02/%*(+&.++%+/)011,&((%./.*/-$&+,(-.,01+/*)*(%*/(/01(/00,,',0.+11,-./(*()'1)%+/,1,2/-,,1,..1/).%),-1///)%&/0+(%,(/0'%*%+%)*+')/',(.#.1/&*-%1*&.%+#%%/1,11),*'20*+),*2-+++'2--2-*,,*00-).(.#)011+1*1+1,,/,$00$(0(*.*')(%&/)/&),&.'.*-)+1+12-&+0,-+,0-*)%*,$($-+%..*+/-/',.*211.0*0'/*-'/1'''+,&0&--20/$(-2-01-%.(/*&2/-&-*,&1--,-.0*00-/0*,./$$1/10(/.0+22,*0&1-.&1211.%,0+)-+-.2*+121++/...&0+$&,+%'&#"%&$*%,01,-/*./.)+&0-0+(/),+*-.*%&(0.$#/-/%/(,,+%.*-&#)*+*.'-+$#*-&+**02/0(1*,/'/,,**/0*0,1++.0/./-'..,,*()%%.&,(&/'(&-1+0)%+1+-',-/,.%-,0,/,,-(11+-11--'(&)()111++/),,1+,0.0)()*,++,%*,+'1.1.-..++-%0,.'%/.%1.+,/&/))"$*//'/+.20.+'02/10/'/'.,.1**//0$#0.&**(**('*-,'((''/.).01,/0--/',,+&-0-.0/1.*+1/1*),+-/10/+12/-,*,--+*)#(&-*-/*--'-.*./&.)*%(&))+.,+,1+-0,,-,*-*-,/,&',-)+.$+--)++1./.-$+,.&-)..,10+,.(/)'$).-10,,011)1,&1*1,,,'2+1,*0)-0,+)+--0.*,$)),)**+-,+0+,,1,2011/*,+*&0/,'&*%#$,-.-#%)&)'+*$+&-'-**/+/*0/,/,-%'-12-,1#.*+,...'02,*,)-/'*%0-%(%%#&-+&)$%$*.-.)..-&((&()&,,.-,&(+.(.0,-%*11*-,+%,*/,$/.$(-&.,1./.,11,//1-)(+$,+,**-((&$'(+%$',&,)*,$%$,.+')/./+,%000.&+/$+&+--&.''/%(/+-111(+'%)'+%-+%,%%))&*'%+-$*/*.-+).%200/'+111+*(00'-.'1-0++1)-)*.-/0/11,,,0+(-.&.)$%+.-//)2/.-//$),1--1,,0,-)'*0)1-(**&*)%,/)-2-10/)*/.///%.0)(,2++')0-.),*%,-)--.%),2.2.//&1+,*+*%,$+-.,.*-+*&11/(/'(*0*,.-..-01/)-02/0/,*-+/&%+$(+(+(,,-.$,/&202++-1-(-00-)*/00)*//(/./+0.0011-/)'%)(+-,),.-+/--110-0)++($+0'2//+0-./-$+*$00101240031.-.+.))%'%('&('(&++&%)*,/.%.,).%&..*-3'5--*,-,(&-,-/+)+$((##+$(+(+,+%%&))(#,*)*)'+,*())*.,-&&&#-$$+,$*('%((##&*)*&&'*+(,'**%+()++)+*$$,---+'(#*),#%(&,-),,&-),**(',,%")$#')$*%*(*),,)&-)$#'(&)--+-.-'',$+,-'-+(,, @rCer/115/1820_65_CCS ATGGAGGTGGGAGTTAGGGAGGCGACCACGAAAACAGTGAAGGTCGGAACCGACAGCCTCCGCCGAAAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGGAGCAGCAGCGGCGGCGGCGGCGGCAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGACGATGGCGCGACTGGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCTCTACATAGACGACACCCTGACGATGGTGATGGAATTTCCTGACAATGTGTTAAATCTCGATGGACATCAGAATAATGGTGCACAGCTAAAGCAGTTCATTCAGCGACATGGTATGCTTAAGCAACAGGATCTAAGTATTGCCATGGTGGTGACATCACGCGAAGTCCTGAGTGCACTTTCTCAGCTTGTCCCATGTGTTGGTTGTCGTCGCAGTGTGGAACGCCTCTTTTCCCAGCTTGTAGAGTCTGGAAATCCTGCTCTTGAACCCTAACAGTAGGGCCCAAGGGAGTCCTGTCTGTAACTAGAAGCTGCATGACTGATGCAAAGAAGCTTTATACATTATTTTATGTACATGGGTCCAAACTAAATGATATGATAGATGCTATTCCAAAAAGTAAGAAGAATAAGAGATGTCAATTGCACTCCTTAGATACGCACAAGCCAAAACCTTTGGGAGGTTGTTGGATGGATGTATGGGAACTAATGTCCCAGGAATGCAGGGATGAAGTAGTTTTAATTGACTCAAGTTGTCTTTTAGAAACGCTAGAAACATATCTACGAAAACACAGGTTTTGCACTGATTGCAAAAATAAAGTCCTCCGAGCATACAATATCCTTATTGGTGAACTCGACTGCAGCAAAGAAAAGGCTACTGTGCTGCACTTTATGAAGGCTTGCGGTGCTGTCCACATGAGCGACACATTCATGTTTGCTGTGAAACAGACTTCATTGCACATCTTTTGGGTCGTGCTGAGCCAGAGTTCGCAGGAGGGCGAAGAGAAAGGCATGCAAAGACAATAGATATAGCTCAAGAAGAAGTTCTGACCTGCTTGGGAATTCATCTTTATGAAAGACTGCATCGAATCTGGCAAAAACTACGGGCAGAAGAGCAGACGTGGCAGATGCTTTTCTATCTTGGTGTTGATGCTTTACGCAAGAGTTTTGAGATGACCGTGGAAAAAGTACAGGGTATTAGCAGATTGGAACAACTTTGTGAGGAATTTTCAGAAGAGGAACGAGTAAGAGAACTCAAGCAAGAAAAGAAACGCCAAAAACGGAAGAATAGACGAAAAAATAAGTGTGTGTGTGATATTCCTACTCCCTTACAAACAGCAGATGAAAAGGAAGTAAGCCAAGAGAAGGAAACAGACTTCATAGAAAATAGCAGCTGCAAAGCCTGTGGCAGTACTGAAGATGGTAATACTTGTGTAGAAGTAATTGTTACCAATGAAAATACATCATGTACCTGTCCTAGCAGTGGCAATCTTTTGGGGTCCCTAAAATAAAGAAAGGCTTATCTCCACACTGTAATGGTAGTGATTGTGGATATTCATCTAGCATGGAAGGGAGTGAAACAGGTTCTCGGGAGGGTTCAGATGTTGCCTGCACTGAAGGCATTTGTAATCATGATGAACACGGTGATGACTCCTGTGTTCATCACTGTGAAGACAAAGAGGATGATGGTGATAGTTGTGTTGAATGTTGGGCAAATTCCGAAGAGAACAACAT + HJK&JKJKKKAKKKJKKKHIKAKKKK0HKKKKKFKK?KKKJK@CKKDKCKIIKKKKKKKKKKKIKKKKJKKKKIKKHKKKKKK>JKKHKKKGKKKKKAKKKDKKKKK0KKKKGKCKKKKKKKKKKKJKKJKKKKJKKJKKJKKKGJKKKKKFJKEKJKKEJHJKKKCJKKK=JKKIKKIKKK8JKBKK>KKKK>JJHJKJKFIIKKJKKCKKAKKKKKK=KJKKKKDKKFKKIHKKKKKKKK>KHKKHDGKKKKKKKKKJFIJKKKKKHKKK0K@KK4KK4JKEKGKKKKFIBB5KKIEKGKK7KFKKKKIKKKK%KK;KIFKKJKKDIKJKIKKGKKKK=KJKKKKKKKKKKK?KJKKKI7GKKKGKKKKKKKK>KIKJKJKKKKKKK/KKKKK9KKKIKKKIKKKKKKKKKKK?KJKJKKKGKKEKDHKKGKKKHJHGJEKIKKHKJ@GKKKKKKKKKKKIKKKK>JKKK1K$:AKKJKIKIHKKKKKK5E0:IDJKFK8JJKKK2GHKHIKIJJCAJHIECKJFIKKIKJK6JKKJKKKK:KGG1EJK%HKKK8JKKFKKKJKHJJFKJKJK>G@KJIDIKBJK:JEABGIKB79J:BGKK?JGJKGFKKDKKHKCKK/=JHJKKDKJC2KHJKJBK?J:JJ=E>EC?D4JGFKAGKKGF5*IKFIIIAJ0JKIJKKGHFAKGIGKKK;GGKEIKJIHKJGJKFFIF4<87H8JKBKKKCKKGIJJ9='KIBAI>IGI?KHEKJJ=IHKKJIKHK=GCJKJGHJKKKKJ>FJKIKAKIK1KGAJC+JKKII'KKFKKKGKKKKJEKKKIIHBGFKKHJKKKKKKKKJ,IIHKKKJCKKKJKFKKJKIKKKHIKHKKFKIKFKDK&KKBJJIKKFIIHKJ5KHJJGKIKKHKDKKKEKKKKKJ7KG@HCKKKJKHJKHJKHKJKKJJKJJKKH?KIIH9KK@KH4HHIIJGJKKKKHKK:KKKKBKDHKG-CEJKJKJGKCEJGBBIJFKFKEGJDCKBKAKKDKJFIKJKJDKI6KB@H?JJHJKKIKKKIKGKIKJFJKKKEJKK@KKJHKE2G1FKBK @rCer/117/2308_58_CCS CCCCCACGGCCCTGGGCCCTTGAAGCCTGGAGAGTCACCGCCGAGGGATGAGGACGCGCCAGCCCGGGGGACGCGCGGCTGCTTCGCGGCCCCAAGCGCGCAGCGCCCAGCAGCCGCGCGGAGCCTGACACGCTGTCCTCTCACCTCGCGCACAGGGCTCTGCGAGTGACCTGGCCGGCGAGCTCCGTGCTGCATGGAACGGCTGCAGAAGGCCAAGATGGACAACAGGTGCTGGGCTACAAGGACCTGGCGCCATCCCCAAGGACAAGGCCATCCTGGACATCGAGCGGCCCGACCTCATGATCTATGAGCCCCACTTCACTTATTCCCTCCTGGAACAGTGGAGCTGCCCCCGCAGCCGGACGGACTGGATCCCGATGGGCGGACAGCCGGTCGCCTGGAATCATCTCTCAGGCTTCAGCCCCAGAACCACTGGAACTCCCCGGAACCAGCCTGCCCATTTCCACCACCCTGAGACTCCCGCCCAGATTCCAACATCTACAAGAAGCCACCATCTATAAGCAGAGAGAGTCCGTGGGAGGCAGCCCTCAGACCAAGCACCTCATCGAGGATCTCATCATCGAGTCATCCAGTTCCCTGCAGCCCAGCCCCCGGACCCCAACCAGCCAGCCAAAATGAAACTGACTACTGGCCGGCCCCCCGTCTCTGGCTGTCGGGAGACAGAATGGAGGAAAGCGGAAGGCGTCCTCGGAGGAGAGCAGAGGAAAGGAAGGAGGAGGAAGATGACGAACTCTGGAGAGGAAATGAAGGCTCTCAGGGAGCGTCAGAGAGAGGAACTCAGTAAGGTTACTCCAACTGGAAAGATGATCTTGAAAGAAGAGATGGAAAAGTCATTGCCAATCCGAAGGAAAACCCGCTCCCTGCCTGACCGGACACCCTCCATACCTCCTTGCACCAGGGAACGTCTAAATCTTCCTCTCTCCCCGCCTACGCAGGACCACCCCTGAGCCGGTACAGTCCACAGAGTTCAGCCCATCGGGAGTGAGACTGAAAGCCCAGGCCTGCAGATCTATCCCTACGAAAGCTAGTGGTGACCAACAAGGGCGAACCAAGCTGCCACCAGGGGTGGATCGGATGCGGCTTGAGAGGCATCTGTCTGCCGAGGACTTCTCAAGGGTATTTGCCATGTCCCCCGAAGAGTTTGGCAAGCTGGCTCTGTGGAAGCGGAATGAGCTCAAGAAGAAGGCCTCTCTGTTCTGATGGCCCCACCTGCTCCGGGACGGCCCCCTTGCCCCTGCTGCTTCAGGCTCTTCCCCGGCGGGTTGGGAGGGGCAGGAGTGGCGTGGAAGTAGGGTGGGCTCCTTTCCTCAGGTAGAGGGGGGGCCAAGACCTCTGCAATCCCGGCAGTGAGCTACGGACTTTCTTCCCCTCACAAGCCTGGGGCCCTCCTGCTCTCGTCCCTGACCCTCCCTGCACAGGGCAAAGCCAGTCGGGGTTCCGGCACACAGAGTTCATGTTGCACCATCTCCCCGCCCCTCACCCCAGAGGTGAGGAGGAATGAGGGGCATTGGTGGTTAGGCCTGTTGGCTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTGGAAGCGGCCAGGCAGAAAGAGCTCCAGGCTCTCGTGTCGCCCACCCATCCCTCCCACACTCACTCCTGACAGCTTTCCCGCACTGCAGCCTCCTGCCCTCTGATTCTAGTGGGAACAGGCCCCAGCTCAGCCTCCGGCAGGGAGGTCGCCTCCCAATTTCAGCTTGCCCTGACCTCTGCTCGCAACCCCCGAGCTTCAAGCCTCTTGCTCCAGCCCTGCGGCTTCCCCAGAAGCCTGGGCTGAGGGTGGAGATGCCGCCTACACATGACCCTGGCCCTCCACCTGCCTCCGGGCCACGAAATGGGAAATTCCAGCACCAAGCCAGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCTTGATGGGTCAAGAGGCCAGGCCTGGCACATTTGGAGTGTCCTGGCTACCAGCTCTCACCCACACCCACGCACCCCCCACACACTATGCTCTCTCAGAATGTATTTATTGGGGCCCCCCCAGCGCTTTCCTCACCTGCCCTGCCACTACCTTACACCCCCAGCTGACTTCTTTCCAGTCCACGTGTGTATATAATGATATCTATATTTGCCCAGGTCTGGGTATTGCTCGCCAGACCCTGAAATCCTCTCCACGTGTGGTGACCATGCTGGGGGAGGGGACTCGCTTGGATAAAAGTCGCATTGGGTTCCC + )*&)(&)&#','**)%++$**(+'*,*)*%,0*/()*0()20-.))&-%/-3')+.,211--20*01-/'.23/0$1-20513$&%)'*141,*,45530--+))$%$-000-,16410,'--0-2/./1*+.*24./41($#3)&-*&(%','/-*1.)(&'$(#(+.*)*+),%%%,)(#($.(,*')&&)',0,2/*/)*%+*&(/*((((,,&(%(&&,)#(%(&+$%(*+'#*-,*)*$''(+,*$&%#'%)+)%+),*'('*0020-+2*+0,)-*011+-,*%+/**.1&+&(),'',,%--+%&//$,*&$))'/(-'#+/))+/.+*+%%%&//,-.,()()$$#%&'%%#$$#"!"%$"!!"$##!"""&$$+/0.-+*-%+*,/+*-(-+)(+%*'--+*+&0)-.+,)$('*%*'/),')**,'*%#$---$*&&%&$(%.#&%)*#*)*&,,'+'&,-'(0*00#)&-)222/'230'4-601)-3--452/3++41.3&.-+$%'2+(.02203(*)(''2'2,(31.31.42,2401262/-53+62551051)3.0+31+*21-*/21022431'$*2'24'/0,.*42.022450+510321-2/0*)02152/)'0($'-/4)2-2.*,0202/4+#'%.//0$015)0*1*.11*4#&)23+3652**1,.-$51()3215-4.5/,/)*.0.311,-050/,.,)-(,*+)&%'.*#*.-/%/0*.$33,&.+//6/0004-,.%%2353-)'1-*+.*/-)542,.2./)/)*+2,*,/)/0-0/-.*3*&002*,#0'461-,+40/1.0546.2/.//013.*.//&&$(($$50/52.3'05.1//00$*)*0346+34)2/10/1*/-+0.+3('2-+)*4/41+*'))'&'&$+$**535200.'.55)+.0.14(045*51411.%1,0*,/)),-%$#-/+(#(%$)+1)21+20*/-,20,'%+.+4+-.($)'2..+%/)&$%%-262/2,1)-++&%%$,021360**-(,,#//-%'/,+40$))30/*'6/$2*-)4-1+.*(/0),+.3053*.0%%**,'-+0,.(('$#)/$%)).4101/)352.-*4/6.0+2(19-()$)-1/.5.1*9:42424-73*028:+-/'41*3202,2.,*6111/%5:54-**/0062.4,),*+)&4473.,+4..4',$3-51/72.$011:8425-44'+11&/5/-$:29;57405/1176/9/7'2+%4(77:.:3083+8&4--,124)024)+'(714.25-+,*/303'%3/+4,;4/%):0'-24.243793-42/-638/0.9,4745)7332(+1'52963144322:.-0/1'53,998&3344802:4369:.591/67:8456/22/47+-30/11-%/)-1.52.741443*374-.3,/0-'.(51643.464663/4/51345%3489.7/752**&7668,.0,284*3,.5(-6--&+,,.)/83--,$0-2,2-2400--43642-2)/12+2+26184&(64+9:7053+3)1)',4312/&)4&2,4/2-1+&,1438;641.8772889-6.-/3302352*()22400023+5:7/-2&54)&+%-(11-5054/-'894656.+25034)*/--*$3.$-,11/-.43335701.343))-))(114/309/.46756967.7706.640328.5*2-'12042125735889-10211(+1)0)0687+5229663.%23--..&.51.,1).*&,540/16/3550.51.**%1/0+2-%(36,55002-.11)/-%///.*--.35-.-0//1-)1/31.)25+)1+..'0*)''+/(,5/)(1%1/6./,021+,+/2,001556..-%'+%+'-2)03&.'4)-132)'/&5.#+)/1%303-*/0)51.0,4+/..3/0,-,#-*+-,/.2111-)*,0-/204552/.6-/3)/0*1''('(+..,'&&'+-*-114.13.'+-'-/*(-'$(+)'$$,/'%%%)+-.%)*#-0)$")&'',,&$',.&(($&#)'),(,'&&"%#%'$%&(&'&,,&'$'$(*+,/+),,)+%)##($$'**,*+/-,+**',*.&0.,+),(000./-,(,*'+#$',&%&)*)*))$$%*.%%&+2.,%*--*$&.+*,'$#).'''&%%$#)'%$%%"$$%%)&#$#$&$%''%)('%&(#$"*+& @rCer/118/1672_59_CCS ATGGGGGAGACAATGAGGAGCACAGCGCCAGGGGGCGGCCTCGCTCCCCTGGCCACCGCGGGGGTCGCGGCCTCCCATTACATAGCGTGTCTCTCGAGCCCTGGCCTGCTCTCGGCACTGCCACAACGGACCTAATATGGCCGCTGGTGCCGGGACCTGCCGGGCCCGCGGAGGGTCGGGACGAGGTCCGGGATCAGGAACTGCTCCCGGCATTCCTCGCGGGTGTATGGCGTGGGCTCCCTTCCCCCTCTCTGGGTCCCGCGAGGAGACTCTCGGGCTTTGAGGTAGCATGGCCCAGGGCTTGATAGAGGTGGAGCGAAAGTTCCTTCCAGGGCCTGGCACAGAGGAGCGGCTGCAGGAGTTGGGGGGCACCCTGGAGCACCGGGTCACCTTCCGAGACACCTACTATGACACCCCTGAGCTGAGCCTTATGCAGGCTGACCACTGGCTGCGACGACGAGAGGATAGTGGATGGGAGCTCAAATGTCCTGGAGATGTGGCTGCTGTCCTGGGCCCATTGGGGCTGCAGGAAGTAGCTAGTTTTGTGACTAAGCGGAGTGCCTGGAAACTGGTACTCTTGGGAACTGATGAAGAGGAGCCACAGCTCAGGGTGGACTTGGATACAGCCGACTTTGGCTATGCTGTGGGTGAGGTAGAGGCCCTGGTGCATGAGGAGGCTGAAGTACCAGCTGCCCTAGAGAAGATCCACAGGCTCAGCAGCATGCTTGGTGTGCCTGCACAGGAGACAGCACCAGCCAAGCTGATCGTGTACCTACAGCGTTTCCGGCCTCAAGACTATCAGCGCCTGCTAGAAGTGAACAGCTCCAAGCAGAGGCCACAGGCGACTGAAGATCCTGATAACTGCCTGGGCTAGGGGTGTCACTTCCTAGAATGGGAAGGGAACTCTGGGTCTAATGGAATCCACTCCTGGCCCACTGTGCCTCTCCCCTCAGCGTCCCTTCTGACAGTGACTCCTCTCTCTCTAGTTCTGCCTGTTTCTTCCCCCTACTCTAAGCTACTCTTCCTTGAGCCCTCCCTGGCTGCTGCTTCTTCCCTCATCCGTCAGATGCAATCTGTGGGCCGCCCCTCTCCCCTGGCCGCTAAGCAGCCTCCATTGATTTCCGCTCGTGTTTATAGGATTTCCACTTAGCCGTGATCAGTAGTTAAGCACAGGAAAATCCCTTGCCACCCCCCTCCCTTGGTCGATGCCATTGATTCTGCCAGCAGCTCCTAAACCGCCTTACAGCTGAGTTAGACGATGAGAGGAGGCAGCAGGGATTTCCCTGCCTTGGGGTGTGGGAAATAGAAGCAAGTTGAGGAAATGGTTGGGAATCCCAGTTAGAACTCTAGAAATTCTAATCTGATTTTGCCACTGTGCCCAGCTCTGGCCCAGAGGGTAGAGTGCCGCCTGTAGAAGTTTGGGGCAAATTTGTTCCCTGACCTGAAGCGGGTTAGAAAGAACCAGCAGCCGCCCCATCCCCGCCCCTGTGTTGAGACAGGTTCTCAAGGTTCAGGGGAAGATGCATACCTCTTATGTAAGAATGCTTTTCCCTTGCTGTTATTCATACACATTTTCCACTTCAAATATACCCAAATATGGCTTTCCTCCCCTC + KKKKKKCKKKKKHJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKEKKKKKKKJKKKKIKKKKKKKKKKKKKKKKIKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKEKKJKKKKKKEKKKKKKKKKKKKKKKKKKKKIKKIKKKKFKKKKKKKJKKKKKKKIKKKKKKKKKKKKKKKEKKKKKKKJKKKJKKKJKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKIKKKKKKKKKIKKKKKKKKKKKKJKKKKKKJKKKKKKKKKKDKKKKKKJKKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKGJKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKJKKIKKKJKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK=KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKK-KKKKKKKKKKKKKKKKKKKKKKJKKKKKIKKKKKKKKKFKKKJKK>KHKKKKKKHKKKKKKKKKJKKKKKKIKKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKCKKKCKKKKKJKKKKK>KKKKKKKKKKKKIKKKKKKKKKKKDKKKKKKGJKKKKKKIKKJKKKKKKKKKJJKJKKKKKKKKKKKKKKKKKKKKKHKGKKKGKKKKKGKKDKKKKJKKKKKKIKKKKKKKKKKKIKKJKKKKKIKKKKKKKEKKKKKKKKKKKKKKKKKKKKKKKCKKKKKKKKKKKFKKKKKKKKKKKKJKKKJKKKKKKKKKKKKKKKKKKKKKKJKKKFKKKKKKJKKIKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKIKKKKKHKJKKKKKKKKKKKK?KKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKEKKKKKKJKKJKKKKKKKKKKKKKKKKKKKKKKDKKKKKKKKK=KKKKKKKKKEKKKKKKKKKKKKKKK4KK @rCer/119/25_1774_CCS ATGGGCTGTCCGCGCCTAGGAGCGGTGGGCTCTGTGAGCAGCTAGGCAGGAGTTGAAAATTTACAGAGTCCTGAGGCTTTCAGACTGAAAAAGGCTTTCTTCTGTCACTGACAATCGCCACCATGATTCATAGTCTTTTCTTGATCAACTCCTCTGGAGACATTTTCCTGGAGAAACACTGGAAAAGTGTGGTCAGCCGTTCTGTTTGTGATTACTTTTTTGAGGCGCAAGAGAGAGCTACTGAGGCAGAAAATGTGCCTCCAGTTATCCCTACCCCTCACCACTATCTCTTAAGTGTTTACCGCCACAAGATCTTTTTTGTGGCTGTGATCCAGACGGAGGTCCCCCCTCTGTTTGTCATTGAGTTTCTTCACCGAGTGGTGGACACATTTCAGGATTATTTTGGAGTCTGTTCAGAGCCAGTGATCAAAGACAATGTGGTTGTGGTTTATGAGGTATTGGAAGAGATGCTTGACAATGGTTTTCCATTGGCTACCGAGTCGAACATTCTTAAAGAACTCATAAAGCCTCCCACTATCCTTCGAACGGTTGTCAACACCATCACAGGAAGCACCAATGTGGGTGACCAACTTCCCACTGGGCAGCTGTCAGTGGTGCCTTGGCGACGGACTGGGGTGAAATACACCAACAATGAGGCCTATTTTGATGTGATTGAAGAGATTGATGCAATTATTGATAAATCAGGCTCCACAATTACTGCCGAGATTCAGGGGGTGATTGATGCCTGTGTCAAGCTGACTGGCATGCCGGATCTTACACTTTCCTTCATGAACCCTAGGTTGTTGGATGATGTCAGCTTCCATCCTTGTGTTCGTTTCAAGCGCTGGGAATCTGAGCGCATCCTCTCCTTCATCCCTCCTGATGGAAACTTCCGCCTGCTGTCTTACCATGTCAGTGCACAGAATCTGGTTGCAATCCCAGTGTATGTCAAACATAACATCAGTTTCCGGGACAGTAGTTCCCTTGGACGCTTTGAAATAACGGTGGGACCCAAGCAGACGATGGGGAAGACCATCGAGGGAGTGACTGTCACCAGCCAGATGCCCAAGGGGGTCCTGAACATGAGCCTTACTCCATCACAGGGGACACACACATTCGACCCAGTCACAAAGATGCTGTCTTGGGATGTAGGAAAAATAAATCCACAAAAGCCACCAAATTTGAAGGGGACCATGAGTCTTCAGGCTGGAGCTTCCAAACCAGATGAAAATCCCACAATTAACCTGCAGTTTAAGATCCAGCAGTTGGCCATTTCTGGACTCAAGGTGAATCGTCTGGATATGTATGGAGAAAAGTACAAACCCTTTAAGGGCATAAAATACATGACCAAAGCTGGAAAGTTCCAAGTTCGAACCTGAAGGGAGCATTTGCAGAGGGAATAGTATTGCACACTTTTTCATTTCTTACTTGTCTAAAAGTAAAAAAAAAAATCAGCCTGTCTCCTAGGTCAGTCCCCTCCTGGACCCACCCGCTCCCTTTTTTCCTTAGCCTTCAGTGCCATGGAACTAATCAAGGGAGGAAAAGGTCACCAGGGAGAACTGGATGGAACTGAAACACAGCAACACCAGTTCTCAAGGACGAGGTGTGTGATGGGGTAGGAAGCTTGGTGCTTATGTAACCATTTTAAACATGGTTTCTATAGAAAAGACCAGCATTGTTTAGCTTGCTTGGCTTTAATTATCTAAAGCCAATGAAATACTTCTTTGTTGATTTTTAAGGTAGAAAGAT + IJ&HIIIFGJKJJGHKFKFKJKKJKH?KKKKJJIKKKKKHKKKKKKKKIKKKKKK8KJK@KKKJIJJIKKKKKJHJKHKKKJKKKKK8KKKKKKKBKKC?GKKKKKKKJKKJJKKKKKKJJKHJKB:KIKKKKJI=KKKKKKKKKK>KKKKKKKKKKJKKKK7KKKFKJIEKI@KKKKKKJK4KKKKKIIJKKKKKKKKGKJHJ/KKKIKKDKKK8KKKKKH?JHKKJJKKKKKKKKK@KKJKK@KKKHBKKKKJJJAKJKKIKKKK=9KKHJBKKKGJKKKKKGBFKKKHKBKFJKBKKKJKKAKKKFKKKKK6KKKKKIKJKKIKGKJKKKJKKKKKIEKA:KKKKKJKKIJKKKKKKJKKIJKKKKJKJJKKKKIHKKKCKJIKJG?KKJICKJKKJ8KKKIKKJKH?G=KKKKJK=KKKKEKJKKKKKKKJKKJKHK>KKH?KHKKKKJJJKKKKKKKIKKJKKKKKFKKIJKKKKKHKKKKKGJK>KKFHKKKKJKJKGKKKKKKFKIKKKJKKKKKK>KKKJKK0KKKKJKJKKJKJJKIKKKCKKJKIKKK6JKKKHKGIKHKJJKKKH1FIKHKKKKJEKKI:KGKKJ6KBJKKKGKKIDIJKBGKKHIKJIFKFIJIKDK3FHJKKJHJK4KKJJ@KKKKFIIK>KIAJKG;GAKKGHJJJJKJKIJKJKKKGKG;KKKJDJE?FKGKEKIKJKKKKJKIKKKKJKKK@;EJIG;KKKKKKE7KKKIKHKJIFKIKJKHKKKKK+KKKKKKKKKKKKJD;JKJKHJJKKKIKJHIJJ6KKKJKKIBKK7KKJ?KKJ6EBKK0KKKKKHKJKIKJKKKCJJDHGKJIBK=FKJJKJKKKFKKJDK?KKKKKKKJHKJCIKKKFKIIJKJKKKJKKKK(KEJJHKIKHKKAIKJIAJIJK:KHKJIKJ;J.=;EGHIC?KJKJJHK4KJK@KBJJJJDKKKKJ;J8KF9KKKFKKKJ;JK6KKFHEJJIGKKKKGHKBKKH5KKKKKEKJBKKKKKJKKAKKDKAKHBJI*JKJJKIKKK@KKKJKKKKCKKFFKKK:KKJKEJBHKJKHKKKII @rCer/120/25_1939_CCS ATGGGGGAAAGGGGAGGGGTGCCTGGAGAGGCGGAGGCTCGCGCGCCTGCGCATCCAGCTCCAGGGACCCTAGATTTTCTATGGGATTCCCAATCTGCAGCAGAGATTTACCCGAGCGTGTTGCGGCAGCGGCTGGGCTTGCTAGGCGCTATCCAAGAGGGATTTAAGCAGCCCAGAGCTCCGGAGAAAAAGAGAGCGAGAGAGAACCACACACGCTTAAGCGTTTACCCGAATTAAATATATATTTTTAAAAAGAACTGTTGAGTTTTATCATTTTCGTTAAGTGACGTGCGCAGCGCTATAACTGCAGGATGGGGAAGCAGAATAGCAAACTGGCCCCCGAAGTGATGGAGGACCTGGTGAAAAGCACAGAATTTAATGAGCATGAACTCAAGCAGTGGTACAAAGGATTTCTCAAGGACTGTCCAAGCGGGAGGCTGAATCTTGAGGAATTTCAGCAGCTCTATGTGAAGTTCTTCCCTTATGGAGACGCCTCCAAGTTTGCCCAGCATGCCTTCCGAACCTTCGACAAGAATGGCGATGGCACCATCGACTTCCGAGAGTTCATCTGCGCTCTGTCCATCACCTCCAGGGGCAGCTTTGAGCAGAAGCTGAACTGGCCTTCAATATGTATGACCTGGATGGTGATGGCAAGATCACCCGAGTGGAGATGCTGGAGATCATCGAGGCTATCTACAAAATGGTAGGCACTGTGATCATGATGAAAATGAACGAGGATGGCCTGACGCCTGAGCAGCGAGTAGACAAGATTTTCAGCAAGATGGATAAGAACAAAGATGACCAGATTACACTGGATGAATTCAAAGAAGCTGCAAAGAGCGACCCTTCCATTGTATTACTTCTGCAGTGCGACATCCAGAAATGAGCTGATGTCAGTGCTATGGACTGCACAAAAGTCTCAATGTTCCATTCAGTCTGCAGCTATTCACACACACACACCCACACCCACACACACACACACACAAATATTGCTTGGACTACCTATAAATGGACTTGCTTCTTGTGTTTGAAACACTTGTGTGCATGAGAATGTCATTTGCTAATGAATTTTAAAAGCATATATAAAACAAAACAAAACAACCTGCCACAATGTGATATGTGTAATATCATTTCATAAAAATCCCTCTTCCTCCAAAGCCTGGGCAGAAATGTACTGCAAAGAGTTATATGATTTCTTGTTCATGTTTTGCTAATGCTTGTATCTCCTTGATTACATAATGTTAGTAGCACTGAGACCCCCACGGTAATGTAACTTAATTATAAGCTATGTCACTACCCTCCTATAAAATAGTATTGGACAGACACAGAGGGACCCTTGGCTCCTGTGTCTGGTCCACACACCACAAGAGCTTGTATTATCAGTGAATATAAATGTACTACATTTGCATGCCTTTTGGGTTTGCCTTAATTCTTACCTCATTTGCATCCTATCGATCTGGAAAGAGCTGTTTTGGATGAATGCAGTATAAAATGTAAAATCCCTGCTAAATGACTTATTAAGTATATCTATCTATATATACATATACACAAAGATATTATTTATCAGAAGTAAAAAAGATGGAAGTGTATTGGTTTCTGTTTGAATTTTCAAAGGCTTCCAATGTGGTGGCAATAAATGTCCCAAATAAATTTATAACAATTGATTTCCCCCTAATTCTTATTTTATAATTTTAAAATAGCAGCAGATGCTAGCAACAACTTACTAAATCTACTCTTAAATACACAACTTTGGAATTTGAAGAATAATGACAACAAAAGGGAAAAAAGCAACTTTCCAGCTTTTCATCCAGGCTCCCAAAAGAGGGACAATGAACACGGCATGTGAAAAGTAGAACAGATTTGTTCATCCGAAAAAAAATGTTCATTCTCTGACAATAAATTCTATCTCAGTGT + 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@rCer/122/0_1078_CCS CAGAATATGCAGTCTTTGAGACGGGTGCCGGCACCATTTGCCCAGGCAGTGGGCAGGAATATAGCCAATCCCACAGCCATGCTGCTGTCGGCTTCCAACATGTTGCGGCATCTCAATCTTGAGTATCACTCCAACATGATGCAGATGCAGTGAAGAAGGTGATCAAAGTTGGCAAGATCCCATCTGCTGTTCCTCTTTCCTGCTCCATCCACTGCCCTTTTCATGGCCATCTGAATGCAGAACTTGCAGCTCTCCTTGGGGGTGGAACAGCAAGGGATACAGGCAGGCTGAAGCATCAGCTTCACCTTCACACCCATCTCCTTTCCGCTGCGATTCTTTCCTTCCACCTGGTCTTGTCTCTATTTCTTCCAAGGAAGGTAGCCACATTGCGCCTCTGATCTGCATTTCCCATCATCTTTGCCTGCTCAGCCTCCTGTCTGCTCTGGCTGCAGCACAGCTAATAGTGGCTTAAGAGGAGTGGGCAGGTCCATGTGCTTCCCAACCTGGCTCCTTCTTCCATTCCTGTGCATTGCCTCTTTTTCTGGCTGTCACGCATTCTTGGATTCCATTTCCTCAATCACATGCCCTATCTCCCTTCATGGGCTCTCTTTTCTCCCTCCCCACGGCTGTTGCCGGTGGTGGCTGTAGGTGCGGACTCGAGACATGGGCGGCTACAGCACCACAACCGACTTCATCAAGTCTGTCATCGGTCACCTGCACCCCCATGGGAGCTAGAGCCCTTTATTTCTCCAGCCTTGCAAGGACCACACTCCCATACCTTCAGTGCAGTGCACCAGGGAAGAGACCTTGTGCCTCTAGCAGTGGACCATGGTCACCTTGCTGGGTAGAGCCTAGGTTGTCCTGGCCCGCTTCCTTAGGGGAGACTGTTGGGTGGTGATGGGAATTGTTAGGCTGGACCCAGGCCACATGGATGATGATGATTCTCCCCACAGGTTCGAACCTCTGACATGGGTGGCTATGCTACTTGCCATGACTTCACTGAGGCTGTCATTGCTGCCTTGCCCCACCCATAGGCCTTGTCCATACTCATGTAAGGTGTCCAATAAAGAACATGAAC 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TAACCTCCCTGTTTCCTATGAATCCGGGCAACATACCCCCGATTCCGTTACGACCAACTTATACACCTACTATGAAAAAACTTCCTCCCCCTCACACTAGCACTACTCATATGATCCACCTCAACACCCATCGCAATCTCCAGCATTCCCCCCC + S$#%%$%+)(%#(&'-,,(&#*()/&.22/433+106466433645456)462,505/46,4-44%./2501./-/0/)/004+2))355.5402305445124434263541.4)5.()-4.453,4.2/525-6552/45112561256466 @rCer/125/25_3486_CCS ATGGGGAGGAAAGCGCAGAGAATCGCCAAGAAATCAGGGTGCTCAGCCGTCTGCAGGTGTGGACCCAGGGCCCAAGCCTGTGGCTTTCAGTCAGCCCAGTCCGCACCTCTCCCGTGGGAGGTGCTGAGAGCACGGGACCATCCTGGGCCCCTGGGATCTCAGAGGCTGGACCTTCCTGGGAGACTCAGGAAGTCCCACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCTTTCTACGAGGTCCTGGGCCTGTCACCCTGAGGACGTGATCGAGGAGATCATCAAGTCGGAGATCCTGGATGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGCGACTTCTCCGCCTTCAAGGATACGGACAGTGAGCTCAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCTGCTCATCGCTTCCTAGCCACAGAGGTCCCCCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTGCTCAAGTACCCAGATGTTATTCAGGAACTCAAGTTTGATGAGCATAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATTCTGCAGGGGAAGGTGGAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTTTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCTGACCGTTCCCCAGCCCACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACGGACATCTCGACTGCATCCGCCTTGGCAGGCAGCAGCAACCAGTTCGGCAGCTCCGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCGGGCCCTCGTGGACTTGCAGTACATCAAGATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCCTCGCGCATGGAGAACAGCCCTCAGTTTCCATAGACGGGTGCACCACCCACATGGAGAACTTGGCCGAGAAGTCTGAGCTGCCCGTGGTGGATGAGACCACGACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCCCACGAGAGTGCCATCTGACAGGAGGGCCCGGACCCCCCGCCTACCCTGCGGGGGCCTCCCCAGTGGGCCCAACATGAAGAGAGGGAACCTGTTAGTCCAGAAAGGTTGCAGATAGATAGCCTGTCTGATTGAGCAGCCAGATGGCCCCCAGCCTGTGGGGGATCTGGCCTCTGCCAGGGACCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGATGGGGCAGTGGGCCAGCTACCATGAGCAAAGGCTGTTTTTTTTACTGAGAGTATTTCTAAACTAGGCTCATCGCTCTTCTTTTTAAATATAATTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAATTTTTTTTTTCCTAAAAACTATAAAAGAAGAAGGGTTTCTTGTCCTGGGAAGCAATGGACATGATCTGCTCCCAGCCATGGCCTTCCAGCTTGTGTCCCTGACTGAGGGAGCTCTCCCTTCCCCCTCCTCTTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCGGCAGAGGCTCGTCTCTTGGAAGGAAGACAGCTCTTCACAGGAAGCAAAGAACCAACTGGCATGGAGATCAGCTGCCTGGGCACCTGCGCCGTAGCTTGTCTGACAATGCGGAGGCCAGGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCCGAGCTATGGAGAGGAGCACATCTGCTGTCAACCGCTGTACCCAGAAATCTCCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCAGGACTCGGCTGAGGACAGACACATCCCCCCCCCGCCTCCCATCCAGCCCTTTGGACAACTGGCCCCTTCGTGACGGGGCAGACTCAAGTGTTAGCAGGGTCTCAGGCCTTCGATTGCTCACCCCTGCTCCCTAGGCCTGCCCTCACTGTTACCAAAGGTTCCCCCTCGGCAGGAGGGCATCTACGTTGGAGGTGACTTGTCTAGTTCTTCCTTTTGGTTCCGGGAGGAACTGTCAGTCATCGGCATCTGCATTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGAGAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTCCCCAGATTCCTTATTTCGAATCCCCAAGCCTCAGTCCCTCTTGGGGATGGGGACAAGAGGACGTGTGGGAAGCCACGGAAGCAGGTTCTTTATGTCCTTTCCTCTGCGGCTGGCAAGGCTCACCTGGCCTTATCCACCCCCTTATGGAACCTCAGGAGAGGACAGCTCCTCCTAAAGGCATGCAGCTTGCAACCCTGCTTTCTCACAGGCGTGATCCTAGTGTGAGAGGTCGTCCTGCCCTTGCTGAAGTTAGTAGTACTGTACCAAGAGCTCTGCCCCCATGTGAATTGCTACCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAGAACTCCAGGTTTCCCAGAGTCGGGGAGGCTGTGGGACCAAAGGTCCCCGTTGGCCCTTCTGCTGGGTGCAGCAGGAGCTGGGTCCTGAGAGCCTGGCCAGTGAAACTGCAGGCCTTCCGCCTGAGTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGAATCCTAACTCTTAGGACCAGGGATTGTCTTGCACCAAGTATGCCTACCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGACGCCTGGAGAGAAGGTGGTGACACCCGTGGGTTCTCAACTTTAAGGAAAAAAGACACAAGACTTTTGTTCCCTATTGGGGGAAAGCCTTAGTCTTCTCCAGGAGCAGCTTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTGTACTCCTGACAGCCTGACTGCCAGGTGGAGCAAAAGACGTTGGTGGGGGTGTGGGAAGCAAAAAGGGGCAGGTGTACACACCTCCACAGTGACCTCTGTGCACACGGTTACCGCCAACTGGCTGACCCTCCTCTTCCCTGGTCCATTGATCATCCTTCTCACAGAGGGTCATCATTATTTCCAAATACTGTTGGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCACTTCCTATTTCAAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGTCCCGCCCGCTGTGTCTTCCGTGTAAGGGAGACCTTTGCAAATGGCATCCAAATGGGTAGGCAGGTCACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTGTGATTTACTTTGGCGTTATGAGTTTGACTCTCGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATAATATTTGCTAAAGGATATATGGAATTTATTTTTGATTGGTAATAAAAAATGAAATATG 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@rCer/126/25_2042_CCS ATGGGGCTCGGCAGCAGCCTGTAGCCGCTGGAGCCGCCGCTACCTTTTCGTGTCCGCGTGGCGCCCGGTCCCCGCCCGCCGCACCATGGAGGGCTACCACAAGCCTGACCAGCAAAGCTGCAAGCCCTGAAGGACACGGCCAACCGCCTGCGCATCAGCTCATCCAGGCCACCACGGCGGCGGGCTCTGGCCACCCTACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTCCACACATGCCTACAAGTCCCAGGACCCCCGAACCCACACAATGACCGCTTTGTGCTCCAAGGCCATGCAGCTCCCATCCTGTACGCGGTCTGGGCTGAAGCTGGCTTCCTGCCCGAGGCGGAGCTGCTCAACCTGAGAGATCAGCTCCGACTTGGATGGCACCCGGTCCCCAAACAAGCTTTCACCGATGTGGCCACTGGCTCCCTGGGCCAGGGCCTTGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACGAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCCGTATGGGAGGCCATGGCCTTTGCCAGCATCTATAAGCTGGACAACTCGTGGCCATTCTAGACATCAATCGCCTGGCCAGAGTGACCCAGCCCGCTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCAAGCACCAGCCAACAGCCATCATTGCAGACCTTCAAGGGCGAGGGATCACGGGAGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCAAAAATATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAAAGCAAAAGAAGATCCTGGCAACTCCCCGCAGGAGGACGCCCCCTCAGTGGACATTGCCAATATCCGCATGCCCAGCTTGCCCAGCTACAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGAGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAGGAGCACCCGGACCGCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACACGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGTGGCTCCCACTGTGGCGTTTCCATCGGGAAGACGGCCCTCCCAGATGCCCTGGAAGATCTGGCCATGTTTTCGATCAGTCCCCACGTCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCTATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACTGTGATCGGGGCTGGGTGACCCTGCATGAGGCCTTGGCTGCCGCCGAGTTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCGCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGATCCTCACCGTGGAGGACATTATTACGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCTGGCATCACTGTCACCCACTTGGCAGTTAACCGGGTACAAGAAGTGGGAAGCAGCTGAGCTGCTGAGATGTTCGGTATTGACAAGGATGCATTGCACAAGCTGTGAAGGGCCTCATCACCAAGGCTAGGGCGGTATGAAGTGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGTAAATATATGTTTTGAG + 781;89/16*:8399>>7858675:89=03;50(2.27<81853*9::73796469:44'%=9'97-:.2:;:.3<<89=:;;,9/=8=6%349+97=584=1,>/3638025#%.74238.33&8:'79=8;9;9<)<76;=-:/183::78:<;751/$39:==(5+982=0:6=:(79);940,(2=*4+/=>047:990--42/00$.2/5553:-61:;36,:31646<-.&7<;(3=86$89>7$:52,@':%<:7(?-/GGF2(5?4@@56.8+:.=88A=3/>:822))+%0<&<$5A67@=+:70;?70-A>A9898-+;24+%<<6:91@2*0/>A,B.8=@5CC<9;>?.=68=;887=4:>C)98('5A1A=(AA,'ABA>DDC)@<9):CB;8<5/G.C4EE)99?'?C/6;C6E@@9BE>9*?5F>*7<,:2ED8DE1BB3FE?A.8<6@9E5*@88:C981;B<83<=A:DEEB5G?;AB;&?907493@BD1023ED+<8DDEC8=CCE4E>B;8=C?E4DD?;D3@4?BDABA0F2>.A1:9B:BBAA8>;C5@82D;E-D229?8F>B?A>8;C7FC4.?506:0=AB>E@7AE6D@A8G.:&?-2B%8/CA2*$3D?;40DC:%7->,1<6D27?4::<#%/77?9A3/?%6$&59&@@%0)*.3>?0864;(<642&02?3471-16C>>/(:;5=3'67<(*>:*78;7142,B-3=<=@498B2;=/C<5C,5>7/:%205+>38,A=@-A=;>$?>>//>527*@;11/?C?C:::.=<(@%@3:=5=>B5494B<:?=1A=3@@537?<5(=<.=*>>:2>3B=7=<-+@5-=::9.?8C-@1<;96:.A+?2?9?7-A>2><8?)97@B;<3?@63>=0@@=,<>37=<=;B>==;><<4A&60+<'5&3:.=59<=B9A:'<@<:A7*350>@$7=@CA77A?A@@>6-<.166;-,;=83@9A72:9B9.:=?AA;@B?:7@@8>@9CB??A;?9C;8B>8:+>A<-=5<9@;>4CC1B-5::;778;&==>>81=5>,:95:4-3-<8CB;C4CC=7<.4717>>8@..>,>695=6:@<6,79><6=6;C::2=>6;866-??+;7*:$=.=C&):;@?1+&9?C1=;=?&<=<>>?:87=0(@BA781<>0?<9;8@+:<<;)AA*B,585@7B>B;CA&4?2/(@2;2:>3@5569)><+=.=465&;958@?>717B>;6?:;@206C?9@@3B)>>25>>9;@968;;BA>C91A@8=;4:3C>?18.77;?;A499B2AABC0>1;70;$+@?>?C??5<<8:?>=974=4/9<7:@>?6A=AB-@BBA-*A?:B>C?4AB<,>?@@?C@0BB=8=>>@C75?,?47?861->;:>@'>=>6=>9<>14:0.;/<7?&>;8?4C3:B?2&9@;B3;<'>563A/7C7%,4::7>:>7)<:=-8305++4,=6;95-#138=48748469;=/::174=;?=;17=3:8?9;970(6870>:9'83)43$58)7897:;7+97*378008717928=;+;/>*8044%;:==754)<8::>>?:;1=609132876'42=5:%-05?=;%42/36+63;;+*7:>=):558=<77768:6>%7/7403;<97%6405=;?=:=:<4<<<=78;54,85.33:0$855+584/..48-:9:::6 @rCer/130/25_2207_CCS ATGGGAGTCTGAGGCGAAGCTTCGGAGCGGCCGGTACTGTTGAAAGCGACAAGTGGAGGCGCCGCTTAGCGGCCGGGACTCTGAACTATGGCGGCTAGTGATACAGAACGAGATGGACTAGCCCCAGAAAAGACATCACCAGATAGAGATAAGAAAAAAGAGCAGTCAGATATATCTGTTTCTCCTAGAGCTTCAAACATCATTATTCAAGATCACGATCAAGGTCAAGAGAAAGAAAACGAAAGTCAGATAATGAAGGAAGAAAACACAGGAGCCGGAGCAGAAGCAAAGAGGCAAGAAGACATGAATCCAAAGATAAATCCTCTAAGAAACACAAGTCTGAGGAACATAATGACAAAGAACATTCTTCTGATAAAGGAAGAGAGCGACTAAATTCATCTGAAAATGGTGAGGACAGGCACAAACGCAAAGAAAGAAAGTCATCAAGAGGCAGAAGTCACTCAAGATCTAGGTCTCGTGAAAGACGCCATCGTAGTAGAAGCAGAGAACGGAAGAAGTCTCGATCTAGGAGTAGGGAGCGGAAGAAATCTCGATCCAGAAGCAGAGAGAGGAAGAAATCAAGATCCAGAAGCAGGGAAAGGAAACGGCGGATCAGGTCTCGTTCCCGCTCAAGATCAAGACACAGGCATAGGACTAGAAGCAGGAGTAGGACAAGGAGTAGGAGTCGAGATAGAAAGAAGAGAATTGAAAAGCCGAGAAGATTTAGCAGAAGTTTAAGCCGGACTCCAAGTCCACCTCCCTTCAGAGGCAGAAACACAGCAATGGATGCACAAGAGCTTTAGCTAGAAGGTTGGAAAGGGCAAAGAAATTACAAGAGCAGCGAGAAAAGGAAATGGTTGAAAAACAAAAACAACAGAAATAGCTGCAGCTGCAGCTACTGGAGGTTCTGTTCTCAATGTTGCTGCCCTGTTGGCATCAGGAACACAAGTAACACCTCAGATAGCCATGGCAGCTCAGATGGCAGCCCTGCAAGCTAAAGCTTTGGCAGAGACAGGAATAGCTGTTCCTAGCTACTATAACCCAGCAGCTGTGAATCCAATGAAATTTGCTGAACAAGAGAAAAAAAGGAAAATGCTTTGGCAGGGCAAGAAAGAAGGGACAAATCCCAATCTGCTGAAATATGGGAAAAATTGAATTTTGGAAACAAGGACCAAAATGTCAAATTTAGGAAGTTGATGGGTATTAAGAGTGAAGATGAAGCTGGGTGTAGCTCAGTTGATGAAGAAAGTTACAAGACTCTGAAGCAACAGGAAGAAGTATTTCGAAATTTAGATGCTCAGTATGAAATGGCAAGATCACAGACCCACACACAAAGAGGAATGGGTTTGGGTTTCACATCTTCAATGCGAGGAATGGATGCAGTTTGAAAATGATGACACTTGTAAAGTTTGGGACTTATAGACTTCTTGTTCTGATGTCAGGTCCTTGTTCACCAAACAGCTAGCATTCTAGCTTGCATGGGTGTTGCATTGACTTAATTTATTGAAAAATACAAATTTTTGTAAATATCAGATCAGTGATACTGGTGTTAGTGTTGTAATCAGGTTAAACCCACTTCCATTAAACTTGACAGGACTATAGAAGGACAATATTTTTTAGTTCATGAATTCTACTTTTCAAATATATAAAAGCTGCAGGTGGGATAAAATCTCATACATGGATTTTTTCGTGTCCGCTGTCTTGTGTACTTTTGTACTTAACCTTGTACAGTTATTTTCATCTCTTGAACATGAAAGAAATGTTATGTAGATGTTCTTTAGAAGATCTGGCCATTTGGTACATAATCCAGCACAGATAAGCTGGGTGGTGATGACAATAAAAATGGTTTTCTCAAAACTGGTGTTAATTTAAGTTACCTGGGATGTTTCTTTGAATTTGTTTTATGGTTTCTGTAGCATTTGGCAATTGCTGTTAGAAAACACTAGCTAGAAATCACCCCCACCCCGGCCCTTTTAAGGCCAGTTAACTATACTACAGGCAATACCATGGTGAGCAAAAATGTAAAAGGTGGGAGGAGAAAACTTATTAAAATAGTATGTTTTCCTATTATAAGGGACAGACTTGGTATTCAGTGTTTGTCAAATATTACATGTGTTATTCAGGAAATAGATTAATGCATTAAAGGGATGTAAGCACTTTTATTTTAATAAAGTGCCTTATG + D@7GDAEF=9DD8A;@+CB@@FBCE:2:8A?:DD@FGE9@CBA@EBAE?78C@C@DB@AGF3GFC54<<;EEC?F@EBB<7;A4=@=?BC?@A+B?=?EC@BA@@>AGE8FADD2?A*?>6<;=C5@D.75=ECEBC8CB4AB/?3B?;:BA2C1BCB(@AACF:EFA@?;D:@9C;@6B+60?3%7<=:>@B3F7=9D=F@0C@955ABA5F%B@=88'@AA5DB?8:@B9BA?7?B?C;?;EAG>:9A@?=<@-A@<<@D??B:->A98/63GEEF=F&;@CCE@@CA:?BDCD=<=C?0A7C@:F?@<,BBA@>CE@B7@EBFA&>>=8?>@5AA>=8:E>/:8?77??>:?:2?;B/@%B2B?C:CF@4CA@>AB4@DECCA9?::E9B@E94::5=ABC9EBCC=E@>DG47;EG<8A5EF=?ED?F6>E9EBDEC??9EEFD=6AEF;DE=A9C8$??7@DFG@A?EC,A0=FE<:B??DBBC+D;BFFFF=B;@993>;36?A9BA.EFFE2@=AC;>FC+D>7CF:E@;@;FE?EC5GFGGE?7B>FA95DCEG<0<>6?@A@:69+:@'9<<4><8?7=;>?9>?@;>1=:#9<9CEECB?:A39::&B/F2AB9EGD?B@C8>E9@;D*?D>?;BAD@AFE<5>=A><,;@>;59:@%0/6B86@;::C>ABA@@E;7;9AD9<)6:38?6<7=>818B@*C-CB<;AEBA9CEC?3:A=0;>A?BBB3:3==BBE>>8>7EC?>5D2;:B@BC=+D:A=E?39>BC7(9G1CDGGA42;CBCB6FFAE>IEA6A@7@@=??B>B>@DDCB1>FHHHC9F4JJJFDA*B?>C<9:EHF@D9'B;>36&?C@H,HD?:GHFGFG3AE??7FDD@>=EC6?ED?:DD6B5BGFG:AAEII@7DEDE7EFAE=ECDD1F:EFIFCF?JGGGHFIH@D&DCB=DBD@=@EA6GB?HI4GH-BAEAJEG?GDBGDDA?>FFD3EC6EB?BHFA<8E;E@BDGFEG8FGEG>GB?E6HG4JI8JE8FI@>AG?B>GF8D7CIIH2EB:8HD?4BE?.=@5EFBDGIDIGIH<<@?EGGFJFDHBBDICIAJHAI>GI3ACF<5,8DDFEE+CBDHDFBBAF@FFA:AD1@FGE3D9FG>H@GC$>-5?ED@5>C8@FHHCFI0HG%=>>AA<9BEDBC-<@>EHEHBH@C@?<0F9B8A@FFH>C?DFIGGFGICHGE<@E?ECHEI>C/>DA%E@@CEDIDGE=):>FCE@:AD4FAFC4DC?CC9:1DBHFHD=GFEFH/@AD>9GIG@D>DDFC?EHEH;(FEFG=;E?EEDGG:EA0C*AFDBFEE5FIEGC:EAIHF?B?DDDG3E?9G2IDIIGE2=HFE<.FD4BA0EEHHG5?BE1C@8CD?;ABBCB;<7?IGGDIGAJJBDEDBFDH==GA/DIH>=EB<>(<>;:AAA3=D2A>IBIDG=?G9CEA'HDJDI8FE=?=9+3@GE?(@>C6A;?CA?2BDG?H9CA=CB@6F?FHF@E8C9IJ&@B@6>DC @rCer/131/25_1772_CCS ATGGGGCAGATGACCCCACTTACGGAAATAGCGCCAAGTTAGTGTACAGTATCCTCGAAGGACAGCCCTATTTTTCGGTGGAAGCACAGACAGGTATCATCAGAACAGCCCTACCCAACATGGACAGGGAGGCCAAGGAGAGTACCACGTGGTGATCCAGGCCAAGGACATGGGTGGACATATGGGCGGACTCTCAGGGACAACCAAAGTGACGATCACACTGACCGATGTCAATGACAACCCACCAAAGTTTCCGCAGAGCGTATACCAGATGTCTGTGTCAGAAGCAGCCGTCCCTGGGAGGAAGTAGGAAGAGTGAAAGCTAAAGACCCAGACATTGAGAAAATGGCTTAGTCACATACAGTATTGTTGATGGAGATGGTATGGAATTGTTTGAAATCACAGCGGACTATGAAACCCAGGAGGGGTGATAAAGCTGAAAAAGCCTGTAGATTTTGAAACCAAACGAGCCTATAGCTTGAAGGTGGAGGCAGCCAACGTGCACATCGACCCGAAGTTTATCAGCAATGGCCCCTTCAAGGACACTGTGACCGTCAAGATCGCAGTAGAAGATGCTGACGAGCCCCCTATGTTCTTGGCCCCAAGTTACATCCATGAAGTCCAAGAAAATGCAGCTGCTGGCACCGTGGTTGGGAGAGTGCATGCCAAAGACCTGATGCTGCCAACAGCCCAATAAGGTATTCCATCGATCGTCACACTGACCTCGACAGATTTTTCACTATTAATCCAGAGGATGGTTTTATTAAAACTACAAAACCTCTGGATAGAGAGGAAACAGCCTGGCTCAACATCACTGTCTTTGCAGCAGAAATCCACAATCGGCATCAGGAAGCCAAAGTCCCAGTGGCCATTAGGATCCTTGATGTCAACGATAATGCTCCCAAGTTTGCTGCCCTTATGAAGGTTTCATCTGTGAGAGTGATCAGACCAAGCCACTTTCCAACCAGCCAATTGTTACAATTAGTGCAGATGACAAGGATGACACAGCCAACGGACCAAGATTTATCTTCAGCTACCCCTGAAATCATTCACAATCCAAATTTCACAGTCAGAGACAACCGAGATAACACAGCAGGCGTGTATGCCCGGCGTGGAGGGTTCAGTCGGCAGAAGCAGGACTTGTACTCCTGCCCATAGTGATCAGCGATGGCGGCATCCCGCCATGAGTAGCACCAACACCCTCACCATCAAAGTCTGCGGGTGCGACGTGAATGGGGCACTGCTCTCCTGCAACGCGGAGGCCAGCGCCCAACAGTGTGGATGTCGATGACTTCATCAACACAAGAATACAGGAGGCAGACAATGACCCCACAGCTCCTCCTTATGACTCCATTCAAATCTACGGTTATGAAGGCAGGGGCTCAGTGGCCGGGTCCCTGAGCTCCCTAGAGTCGGCCACCACAGATTCAGACTTGGACTATGATTATCTACAGAACTGGGGACCTCGTTTAAGAAACTAGCAGACTTGTATGGTTCCAAAGACACTTTTGATGACGATTCTTAACAATAACGATACAAATTTGGCCTTAAGAACTGTGTCTGGCGTTCTCAAGAATCTAGAAGATGTGTAAACAGGTATTTTTTAAATCAAGGAAAGGCTCATTTAAAACAGGCAAAGTTTACAGAGAGGATACATTTAATAAAACTGCGAGAACATCAAAGTGGTAAATACTGTGAAATACCTTTCTCACAAAAGGCAAATATTGAAGTTGTTTATCAACTTCGC + KK)KKKKKKKJKK7KKKKH?EKK&I9KHCJGKK;KBKKHKBJIKHGKDB=>EICEJ7?AB?=KIJAHAHKGJJDFKKKKKKKKKJKKK7KHJ5KJJ4KEKIKHBK6IH?JKKGKKKKK,KKFH1KH@GHCKKK%IK9JKKJGKK?KKKJGKJKKKKJKKJ:KJ*KKK?IKKBKE9KEK?CK@K-EG9KKJ5KKJGHGB4KKIKGK-KKKKKEKIKKJ7F9KKKJ0KKDK@KKKEJIHKKKHDKJJKIEK=KKGKK>KKKK2KHKKK@GKAFIJKKJEKHKIJ>GKKHFKHKEFE6:K$KHHFKEEK5DFG2H0D16IAKKGK7KD@KJKIFJFGK=KFDFKKEKJKJ@@&GKKKJJ5H*JC:K=K)KKK(KG0KKJEKFKC>JGJIJ6K;JF&KJKJIKKKIKKCEKKJ:=KJFBK;K4KKJEKKKHKCHI9K6KJKJ'I3BEHKKFKAKBKKKGFJKICHFK.KKIFKFKJBK;HK&KJ?HJKKKJKK9KJKKGFEHI7KKK8KIKKKKJ=KIFKKHKKKKKJK5KKKC5KKCJGBKGKKK>KF2KKJKIK&KKCJD9KGK9K6KKIKJG?GG?GFFJJKKKIEHKKGKEJ=K4K%KB1KGK;K3KHKKKKJKKF>JKBFFKGJJGKBJ>KGKCKKIKG'JE.I9KEFKKK@KKKKJG,JEJG:K@KF=EIE6J*GJDKJEAK=JJIIGFA(JK6KKKCFKK5EIDKGJHIJ;EKC6JKKIEBAKFFEJ:JFBKDKFKJ5H63K9KFGII-HHEKJKGGHKIKIHFBIJIJHJIFKJ:IJ7KGKJIHKFH3KEJFJHK:I:GKD6FJBF;J@BFKK>EBF5@K;JFK?IKKJDIJAKJJAFC@JGKHC8AAGDII>EEFKKBJFKF?5KJIIAKJ@E)J>>KI7KKJJHKH@FJFIKKCAEAKJKIK;KKKJKC?,KKKHIJJDKK=*IF.J&F98KJ:HIKDHGHEJEBHKBK8K:KEKKKKJ=JEDCJE4KKJ6KIBI2JJCKED0IG(BDGKIII=.KKIIJKFF&KKGA=2;FHIHK7KDKK?KJBGJ/J@'JFIKJ?KKGHKJKKGKIKJ @rCer/134/1914_59_CCS ATGGGGGACGTCGGCGCGGGCTGCACCGCCGCGTCCGCCCGCCCGCCAGCATGGCCACCACCGCCACCTGCACCCGCTTCACCGACGACTACCAGCTCTTCGAGGAGCTTGGCAAGGGTGCTTTCTCTGTGGTCCGCAGGTGTGTGAAGAAAACCTCCACGCAGGAGTATGCAGCAAAAATCATCAATACCAAGAAGTTGTCTGCCCGGGATCACCAGAAACTAGAACGTGAGGCTCGAATATGTCGACTTCTGAAACATCCAAACATCGTGCGCCTCCATGACAGTATTTCTGAAGAAGGGTTTCACTACCTCGTGTTTGACCTTGTTACCGGCGGGGAGCTGTTTGAAGACATTGTGGCCAGAGAGTACTACAGTGAAGCAGATGCCAGCCACTGTATACATCAGATTCTGGAGAGTGTTAACCACATCCACCAGCATGACATCGTCCACAGGGACCTGAAGCCTGAGAACCTGCTGCTGGCGAGTAAATGCAATGGTGCCGCTGTCAAGCTGGCTGATTTTGGCCTAGCCATCGAAGTACAGGGAGAGCAGCAGGCTTGGTTTGGTTTTGCTGGAACCCCAGGTTACTTGTCCCCTGAGGTCTTGAGGAAAGATCCCTATGGAAAACCTGTGGATATCTGGGCCTGCGGGGTCATCCTGTATATCCTCCTGGTGGGCTATCCTCCCTTCTGGGATGAGGATCAGCACAAGCTGTATCAGCAGATCAAGGCTGGAGCCTATGATTTCCCATCACCAGAATGGGACACGGTAACTCCTGAAGCCAAGAACTTGATCAACCAGATGCTGACCATAAACCCAGCAAAGCGCATCACGGCTGACCAGGCTCTCAAGCACCCGTGGGTCTGTCAACGATCCACGGTGGCATCCATGATGCATCGTCAGGAGACTGTGGAGTGTTTGCGCAAGTTCAACGCCCGGAGAAAACTGAAGGGTGCCATCCTCACAACCATGCTTGTCTCCAGGAACTTCTCAGCTGCCAAAAGCCTATTGAACAAGAAGTCGGATGGCGGTGTCAAGAAAAGGAAGTCGAGTTCCAGCGTGCACCTAATGCCACAGAGCAACAACAAAAACAGTCTCGTAAGCCCAGCCCAAGAGCCCGCGCCCTTGCAGACGGCCATGGAGCCACAAACCACTGTGGTACACAACGCTACAGATGGGATCAAGGGCTCCACAGAGAGCTGCAACACCACCACAGAAGATGAGGACCTCAAAGTGAGAAAACAGGAGATCATTAAGATTACAGAACAGCTGATTGAAGCCATCAACAATGGGGACTTTGAGGCCTACACGAAGATTTGTGATCCAGGCCTCACTTCCTTTGAGCCTGAGGCCCTTGGTAACCTCGTGGAGGGGATGGATTTCCATAAGTTTTACTTTGAGAATCTCCTGTCCAAGAACAGCAAGCCTATCCATACCACCATCCTAAACCCACACGTCCACGTGATTGGGGAGGACGCAGCGTGCATCGCCTACATCCGCCTCACCCAGTACATCGACGGGCAGGGTCGGCCTCGCACCAGCCAGTCAGAAGAGACCCGGGTCTGGCACCGTCGGGATGGCAAGTGGCTCAATGTCCACTATCACTGCTCAGGGGCCTCTGCCGCACCGCTGCAGTGAGCTCAGCCACAGGGGCATTAGGAGATTCCAGCCAGAGGTCGAACCTTCGCAGCCAGTGGCTCTGGAGGGCCTGAGTGACAGCGGCAGTCCTGTTTGTTTGAGGTTTAAAACAATTCAATTACAAAAGCGGCAGCAGCCAATGCACGCCCCTGCATGCAGCCCTCCCGCCCGCCCTTCGTGTCTGTCTCTGCTGTACCGAGGTGTTTTTTACATTT + :=CGAB2=IIHCJ9:<6?=B::EG>@8ADA?A1?/BB:?89=A4@CC@@AB>CA:==BA80>>+?;GEB8BCE4:CDD@F;D>EBFBFFA9@A@?>:2'AEDIHHF@?AEBB?9@GIDCIHFHDFI7GHIB>FGFIGCDIJ@FBGBC>DH@FF@F1?EGF2BIFCBEE3=D8DHEFCADFFED?.AEHG;GII=HGHABB<@?A>=G??IBGCG7F?;<4:CBFFD9?>FE=F;+DCHDCE>8D?9=FHDHEGF>CIJFCG>AE>@ICHFEFIHFH>H?IFACDGG/BG:J@FDFBCE3EBA1@>@4E?CAEEHFF@DAGEFBED@>6+>DFE9?CDDA@>:@BA:CEBG8:C4E4>F6FCFDE3EDHHEC*FDFE,@CGDCEAD/BCC>A6HDCE@;9DDE@@GHC>BGHCA@FG6CFGFH?HDCBEFDHA>ECHI5JJDEBHAEECEDDFFI@HIFDHBDF7H?IICFC=DIDHCEHDEGGA3A?D=E=FB>;FECHIDGICIIFFEBEEDFB7DG9AC@GF,GDF8AECDABB7FGH:@FCDEGED@8G?>=CH8C@D6A?8=@D?D;FEJEHFCCHCH=@C6G;AA3CF#FEFGIFGEBDHCFAJGHE6DC=IAF?CCDBF;DGGFIIGG=GJ>@>A7DFCHH:HDF?9FBG=H?>F3HIE?E@=FHFBGHFB4FBBEFGICIHJHDIFA@AE1@HFG0G;HHIIIG;EHECGE=A?ACDF5DEFAA>FGAECB<2DDABCB?G:GFCC8D@GG@BAB@E>=;DD@ECC?BAEFAABFB??@BDC/FC>??E@@FBGC:;EFFFDFAEBGB@@FDA;CBBDB?E=?BED@C2?GBBDB>@3DGGA;@FGBBDADEGFCCDD@BC?5FD@BE:A2B==?E>DBBABADC8E@=5@7?@2>D@7BAFECBA>?/AEAEEFBFDGEEE>GCCA5GFB:=?8@BDC=ADGCDFA=FCC:@;77?GE8@=9FEECBBDA;DBB@A3FEC@=FGDD>C>DEG@CC:>@@BA=61FC>FFD=5?1D>EF7FFECC;CD?>EAD7A?E@ADBCEFCBFCGAG9ECCF?8EAGDE;DFACGGDFBF=FGCDB@EBDBECA@=GB=?C4@D>:DCEAA2EDEBEGE6DED@@D?EEAFF9E1DCECF?EFBE=@DGCDBD;FDABEA;AA;E;EDDFA?CBBC4CBE:;/BD9EGFDFDDBBCBGE>A?1D@=9ABEAGB9AB2?EFCADD><3=C?F><BDC?2@E @rCer/138/0_1165_CCS TCTCCGCAAATTTCCTGCGCAAGGTTCAGCATTTGAGGGTGACGATGGATTCTGTGTGTTTGAGAGCAACGCCATTGCCTACTATGTGAGCATGAGAGCTGCGGGGAAGTACTCAGAGGCAGCAGCCAGGTGTGCAGTGGGTGAGCTTTGCTGATTCCGACATAGTGCCCAGCAGTACCTGGTATTCCCACCTTGGGCATCATGCACACAACAAACAGGCACTGAGAATGCAAAGGAGGAAGTGAGCGAATTCTGGGCTGCTGGATGCTCACTTGAAGACGAGACTTTTCTGGTGGCGAACGAGTGACATTGGCTGACATCACAGTTGTCTGCACCTGTTGTGGCTCTATAAGCAGTCCTAGAGCTTCTTTCCGCCAGCCTTTCCCAATACCAACCGCTGGTTCCTCACTGCATTAATCAGCCCAGTTCGGTGTCTGGGAAGTGAAGCTGTGTGAGAAGATGGCCAGTTTGATGCTAAAAAGTTTGCAGAGACCCAGCCTAAAAAAGATACACCACGAAAGAGAAGGGTTCACGGAAGAGAAGCAGAAGCCCAGGCTGAGCGGAAGAGGAGAAAAAGCGGCTGCCCTGCTCCTGAGGAGGAGATGGATGAATGTGAGCAGGCGCTGGCTGCTGAGCCAAGGCAAGGACCCTTCGCTCACTTGCCCAAGAGTACCTTTGTGTTGGATGAATTTAAGCGCAAGTACTCCAATGAGGACACACTCTCTGTGGCACTGCCATATTTCTGGAAACTTTGATAAGGACGGCTGTCCTGTGGTACTCAGAGTATCGCTTCCTGAAGAACTCACTCAGACTTCATGAGCTGCAATCTCATCACTGGAATGTTCAGCGACTGGACAGCTGAGGAAGAATGCTTCGCCATGTCATCTCTTTGAACAACAACAGCAGCTCATTTCTGAGTCTGGTCTCCGAGCAGGAGCTTGCCTTCGCTGAGTCCAGATTGCAGTGGACTACGATCATACACATGCGGAACTGGATCCTGGCAGCGAGGAGACCAGACGCTGGTTCGAGATACTTTTCCTGGAGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATTCAGGCAAGATCTTCAAGTGAACATCTTTGCCATCGCCTAGCTGCCGCACTGCCTTCGGGAGATGGGGTCATTAAGGAAACTGAACATT + S,+/654)11(3/)/0/,%63:&543&4413/3571-65614::904:6-1&(0.566-:<006-61):60*78=?>/>=<36658773=:%9;6$.+0>;4,3.59?=27-(&1)4):66764)+>9-75$.595<1/::9533*'4891--49;&7+8534+46+$,013+006-,30)+16))$77&%&&3040%243'565-&-,*9,*4151,&$2/59933:664/:6(.3&644703(&82(7&974326:79,3%.(3:=:801*96-:7;:12$58/;>:=79;9$55908638*74:6+/5&3+4127::&,5586655355.&)14-0442+411176:28557&2993(3..((/209:(56698'-5,67+752:,214-99:758.9-8487-1&/51704/53:65/;88'&0/+2%6/4$$71*5179095/148,0187-7203&*&,53'67510546(8:::%%3579-32,,$0264&61'333000,)899'/0)#"%/342%0,::-:&0*(9$08:85;5687/62&.05&538-999(038'2,04/-:762&.*//.5,767-18&73:4472.3-0-40:0..+6498437/6+66915,:94331-63)4/2.-*,8'(3)89477:65::*+68&02*935077+0(28188.34737-29,83146678665'.(,'477819-:17636665650(0'584640/2233199/6+0)2&2+6:6546;-63+*404(4&90*8&78+57865696/864443&25729+.4,6-6-66:474/99758325763-:1-1-97//'2(,3:.662(378/9185977$14/0.)1/24)213(*61035&$.0453&(/#31,,1#'4/(411035*(.00%025/(/*5.0$,-1$.430%$/)5554161*/*3$11141-10622/-)$")#&+/1+00+55)1/.10/-15521/#.,55645*44*555,+,30320+/52255515,3.5((10.#*0&350163%/.'/+-#)%1*141,2(+/)444*040-6*54/1')-0$22*5151//50-0&*))3*2,,%#-4.020%,'/,1+(++.,#..!$-%0.5$!162200%230&.131(2*/)640*-)-..16 @rCer/139/1801_58_CCS ATGGGCTTTTTTCGCAACGGGTTTGCCGCCAGAACACAGGTGTCGTGAAAACTACCCCTAAAAGCCAAAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTACAAATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCTTGGATAAACTGAAAGCTGAGCGGGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTATTATGTGACTATCATTGATGCCCAGGACACAGAGACTTCATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTGTTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCTCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTGTTGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATACGAGGAAATTGTTAAGGAAGTCAGCACTTACATTAAGAAAATTGGCTACAACCCGGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAGGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTGGTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACTGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGAGTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGTGCTGGTTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGACAGTTGCGGTGGGTGTCATCAAAGCAGTGGACAAGAAGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTT + */;?$099=>9%>BBA:>>=6<:*<@4@?70?A<>=AB>@=<79<;=2BC<@A;/;??8?A@A<>B@2=B?@C@=B=?A<?BABCC?BB@:?C@@6>>479:=7795<=A>B?B<58=8;?6;;7C3BB=A;2;B9=44:-=7:=&:>?@=*8@5@A??=C?9>79??C=B;B>1B@5@?9@A/@AB?A?AA5=@AB>A>:@B6?CB>A4<=@C8;;;BB:B@9><=?@68B884C>A:>;7B@C?@;A?95:1.1;4'2=568,(4:=99:8*=??A;B:815B?>A;/:><;9;97@:CA>B=@B@4A;>=6:<&4=0=@1;B7@@:8:/7341;>@;4=95462?;8@@>C;A:?4<9=;;59AA=8>@8A?@>:=@B<:@*??9?>=A69?;8-8?=9>3>38;9;8=86>=33/==<>5;=69;;5;8;>=89=68=.4::92;6=>:>5<2?9>=:7=/08158905/2=96>8+482/*9::;<;:123<420702-==:3;=97*78/<>:6>=>?=;:>84:6?:1342<7>:>7?=<:19;<:0=5>8?=;56<=+;0>77>>8?;7=-;=>:>>3?=82=094:477=>=9>;;9-=9;38=7==5*204-<067'=::==78?=<-943>>?79:=1=8<6.=;?>9489==51>=;:=0;;9;?=?6318)28:461*=7516;;93?99864<8<5=;786(67;:14),3939/46;53=7=7;<<769<35+13.56-<4::8>:2:?6>9>9>;;6;77<:>=><<.6'089>;;>69;34>8:>9:+8455'15=;9:'::>>?>;;;;:4/77<8;A;>;9B>A=C=BA?A@5:3*,6377B>A=1<1A;C?=70AC=;@:CA@B;BCC=992;67:>BAC=<8;$<801<1>AA?B@C><;=?/8;*?3=@6:(>ACBA@=>A:=.@:A8=5<@@>=@CA?=BC=C4B9.:;,8@=B;CBCC??89;9&3;@=<6@7BC?9<6>;9=>?=;>98*:8<2;4<8:3789?==/<::$;893=:<:9?89;265301<;:87$6>>8>5;=9>;5832=867;44/=;=9;;=1=;9;928:265>7?;<31>6==;4:97<<;<7<93&06<:=>?<==>928<9<5--5447:545.53057937854604775651541:86777958;6:75:8130633855833*:7*8999,8;34755045.64978569;68415974863:33787635,5779+8:9836623016;77:73+1.5.48993074:591783582-23457122536253382)62822:55;88678566)/10/3$.45&.9-2(6+6439;457435&/:2.5455/14:674070612:94)%695-8383110668(55;:7406397;5590186333878#/6646986567%98875/::7:7:184330/3/5:4;;6660958:;9:9:67::.677-53185989983*5186*.6,39197731667456.89.879:72281596-776-:;86;589998-764, @rCer/140/44_3568_CCS ATGAGAGAACCACATAGTCCATAGAGGAGAGAATATCGGGAGGAGACAACCGAGACAGAGGCAAGACAGGATGAGAGCTGCAACCAATGCTGCTGACTTAGACCTAAAAAACCATGTATTATTAAATCCTGTCTTCAGGCCCCAAACTGTTCTGTTCAAACTATCTGACCACCTATCCAACAAACGGTCCCCTCAGGAACCATCATATAGGGGCTGAAACCTGACAACTTGGCATAGAACAAGTGCACTTTGATTCCAGAGAGCAGAAGTTTGAGAGTAAGAAACAAAATAAAGACCACCTAACAAAAACGAAACTCTGTATTCTCGCCCACTACATTACATGCTCCCCTTTGTGGATGTCAAAGAGACCAGAGGAAGTGGACCAGACTAGAGAGAATCTATCGTGGTCTTCTAAGGAAGATTAATCAGAAAATTTTAAATCACAGTTATCCTGTTCACCTAAAAAGCCAGAGTTAAAGCCTCTAAATTAGCCCCAGGAATGCTTAACAGAGGAACAGTAATCGAATCTTACAGATTGGAAAGTGGAGGAAGACCCTATCTGGGAATCAAAGCAATAGAAGCGAGTGCTCAAAGTGAAAACTCTAGGCAAAGAATCCCCGACAAATTTTTGAGGTCAGTTTTGTTACCAAAAGCACTTCTGGATCCCCGAAAGCTCTGAGCCGACGGCTCGATGAACTTTGTCGTCAGTGGCTAAAGCCAGAACCTCCACCAATAGAGCAAATTCTTGGAGCTGCTCGTGAACTGGAGCAGTTTGACTGATCCTGCCTGAGGAGCTCCAAAGGTCTGGGTGCGGGAGCACCATCCGGAGAGAGTGGGGAGGAGGCTGTTGAGCTGTAGTCGGAAAGATCTGGAACAAGGAGCTTATGAGTCCAGGGAACCAGGCTCTATGACCGATGAACATGGACATTTCTGAAGTATGCTCTCGTAGAGGTGAAATCCTGAAGGTCAAGCCAGGAACCAACAGACAAACCAGCTTCAAGCTATGGCTGACACAAGCTATAATTGAATCTTTTCGACCTCCACCAATTTATCGGAGAACAAAGATCGAGTGAAGATAGCCTGAGAACAGGAGTTGGTATTCAAAAGCAAGAAAATTCTTAAAAAGAAATGGAACATTTTGGCGGGATAGCAGACGTCACAAAGAGACGTATCTTTGGATTCTAAGTTACATAAGAGAAACTGGTAAACAAGACAGGCAGGCAGAAAAGCAGCAGGACATTCCAACTCGCAGAAGACGTCCACAGGTTCAAAGAATGTGGAAAACTCACTAAGAGTTCAGTACTCTTAGACCAAGAATCCACACTGGGGAGATAGTCCATAATGATGGTGAAGCAAATGTGGGAAGCCTCAAGCCGGAGTCAAGTCCTGAAATGAACATCGGCGGAGGCCACAGCTGGAGAGGAAACCCTTCAGTGAAGCGAGTGTGGACAGCCTTCTAGTGCTCAGCAAATGGGCTCCATCACTAACACAGAAGAATCCACACAGGGGAAAAACAATGAAATGCCAAAGTGTGTGAAAAGGCTTTTCCTTTCTCAGCTCATGCCTTGTTCAGGTTCATCAGAAGGAAAGCACACTGGGAGAAGCGCTAATTCATGCGTGAGTTGTGGACCAGCCTTCATTCAGAATGCAGGGCTTTCCAGCAATCTCCGAGTCACACTGGTGAGAAAACGCCTATCAGTGCAGTCTAGTGCAGTAAAATCTCTTAGAAGCGGACCCTTCTTAAAAACATCAGAAAATCACACGTGGAGAGAGCGAAACAATGAGTGTGGATGAGTTTGGAAAAGCCTTCAGTCATCATTGCAATCGTTATTAGCATTATTAGAATCTGTACCTGTTCCAACAGTAACTAGACTAATTCCTCTGATGGACCCTCAACCCCTATGGGGCCATTACTTGGAAAGTAAGATTTTCAAGTTGGCCTTATTCTGTTCATATATAAACTTATTTTTTGCATTGCAGTGATCCAATTGTCTACAAACCAGGTGTTGGTAGCTTCTGTGATGGATGACTGTGATTGTAGGGGGTTCTGGATGGCCCTCTTATTTCCCTATCCTTTGGTCCATTTCTAAATGATTTCACTTTAAAGGGACCAAATCTATATGAAATAAATTGTTATGGAGGGGCTGTTTTGAGGCTAATATCTCGAGCATATGAATAATTCTAAAAAGACCAGTATCTATTATAAGCTTTTTAAAAAAGATTGGCTAAGATCAAAAGGATATTCAGAGGTCAATCTTTTTCTGTACAGAGTGCGTAACGTTTAAAACACATAAGTGTTTTGGGAATAAGCAATTGTCCACTTATTCCCCAACAGGAAACATTGCTATGTCTCCCCTAGGAATGTGAATAGAATAGCTTCTTTAAGCAGCATTATTCCCATGGTATAAACAATACTCCGTAAGTTTTTAATGGTTTAAGGAAATCGTATGTCTTCGGAAGTAGGTGATTACCAGGCGTGGCTCACGCCTGTAATCCCACCACTACTTGGGAGGCCATAGGCCGGCGGATCACGAGAAATCAGGAGATCGAGACCAATCCTGCTAAACATGTGAAACCCACGTACTGTATAAAACACACACACACACACACACATCCTACACATCAACACCACAACACACCAACACAACAACACATTAGCCAGGCTGGGTGGCGGTGCCTGTAGTCCCAGCTACTACCAGAGCTATGGCAGGAATTGGGCGTGAACGCCGGGAGTGGACTGCAGTGAACTCAAGAACAGCGCCACTCACTCCACGTGGAGCGACAGAGCGAGACTCCATCTCAAAAAAAAATAGAAATCTAATGTCTCATATCATATCAAATTCTCATGCTGTGCATTACTGTATTTAAAGTTTTCCATTTTGTTACGAACATAATAAGATGATACTTTAAAAAATCTCTCTTCTTACACAAGTACCTCTTTAATTCAAATGCCTTTTAATGTCCGCATATTATCTTTTTGGGGGTTGTCAGCAACTTTGAGTGCCATTGCAGGCAGCATCATGTGAAGTAGTTTATAAAAAAAGAAGTCTGATATTTTCTTGGGCACTTGCTGCTTACTAGGTAGAGACCAGCATGCTCAGACATTTATTGTTAGGGATTAAAGTTAATGCTCTGGCACCAGAAAGCTGTCAAAGATTTTCCTACGCCCATTTCGTGAGTCTGTGGGACTTAGGCAACTTATCTACATGCTCCTATCTAATAGTCCCATCTGTAAAAACAGAGGATGACATCGTACCTTCTCATAGGGTAAATAAGATTAAATAAATAACAAACTTGTACTTAAAAAATGTAGCTCTCAATTAATGTAACCATTATGATTAACAATAAGAAATAATTACCATTTAACAAACTATAGGAGAATTCATTATAAGCTAATCATGTTTAAAATTAGGATATTGAAATGCCTCTGCTAGACATTGTGTACTACTCCCTTTTCTTCCATAGTCTAAAACCTAAATGCAAGTAATATTTCAAAAGAGTGATGAAATAATACAGTTGAGTCC + .,)#-.-).,/--.%#-"%++'#(')))$(($&"&*-++*,-(+$.,##&-.(/*//-//,/%,.),/-,*.././.-.-.*#&-(+"-..,./.#-,-",),#-$$%$$-,/*/$"..."-$#+%"*/,//.-$.).()))/+%*.(+%-/-"-&,'#)./-,--('-/.+/-+/%%*./-%/,#..'**-//"-.%.#-#+/.--#*,*+,/.%,%/,//../-#.-%*('./#--#.)&...#--,&'/..&)-//&/.-/./+//,+%-.-$/.+--+&,.,-))*))//-.#,(-").-,#(*//.&+'..*+,.//#./,.(-/.+"&.*-/+/./".-'*)-.*+&-'#/)...*+/,.+/,/.#'-.+///-./"//-/...%,,..+/"/#+-(/.%-+*-/.+*&-,),"'%.+/.//%+*$(-+*,-*.//,-/.-,/%+.)"--./%..,$+%./,..//+.#+$./+.//#,+/-/*.*++//.-+////(-#...//..%..///)"///%.//-.&///,..-.+&..%,-+.-+*/&*"//././,+-($/&+#.-$),%$*$)(+))&,(+-.&(-.--*)+$'$&+--**%%,-%,"%$%,-'-%(#'$(%(+',*"--.,+%..-+,+/"&*./"/.-/./.-"-'&#-&,*..."..&)-*-.(..+-.&--"-),%-+-(-..*.+,.-*--,&..+///*%$&$(-.&,$/#.././,*/$..(,-,'-+#-.//,.-"#//,-/-///.+.'/.+"//*-&&,"-..,+.,./*,"$-.+%//,-././-,-..//#*/.,-$#/.,.+./*+*+.+,./,../-&-#//*/-./'-/$)&.-./-/.-)//+.-*///.//*/.-#.&)*-,+/,///-./.-/#/.-/#///*.///.+../+,/../+..#"//./..,+#&,--'.(+**/&"%-,&$..-+/.%-.#&'/,/*..."./"-#-////-).%-//+//.+$/+///-)#..,#/+*/'.."*..*)***#+//,/.-/*//+*#&..*-/*.."+/,/.#/".//*/./.'"(-.*.$)///*,/-+,..-*.'$'**../"*/,%)#$".,--($*+/-+//).+/-//,).&(/),.///.-///.),.#*+&/*.////.(///*-,-/,/*/%/..#.//*"#../)$../#'.)'.&+.///--&//.+,+/-**.///*-/.,/**"-+.)"-+".///*//..,#,/./+..."/,)/.*/*//.#-'*/-/$/.$-."//(//+.-""/--,.*&,*)//&./+/...//*+,+..-#."$-&//&.,-&/.%.,*###,*//,-,-,+//+/),$+),/..'/'.*/&"+//.+*,//+/././*,/-+.%,+../."...-/./#.+*,'++./..//+#,&".&.(&-'..*/-+.--.".#/.-#///.,+/-"#,,"#."..//.%/////,+//+/.%-)/-..,*%*)#((/.+,./-&///(),*.,/.&/.*-+&//*.#*%.).-%--".%-..'/&-+/.&++/..(.+"-(--*,+(..,%,$%.-/./,,'.-+/,./.#($-#/&/./*#%..++.-.-*-#.-&/,....,-./+).$//-*+-.(.,.../#,+/.(.+&/../-//..//-,$,((/-"+../&////)///.-#../*//-.,(*'#,.,**-+*(-++--(+.-&.,.-+(*//,././+%%.-//..(#/--+-.,-++&+(,#$#,---../##/../+-+---,-*/.+/,&//-+.//.&.),.*///"(-.../*/**-"+.+/*/--+#%.#/-,-,&,$-%-.%*-.-././-*/)/,#+,//"..-%)+-./)/*+),.+/,+-+,*/"/%/-*+.-+-//&./-,'(,/+//#..)-"',/.)./*-//(////%,$/.%//.*(*+..-/..+/////'#,/$,+.///.//-+.)/.#-,&+,../#(+%+..-//#---&././/,/./..//&,)*-'+(..--#.*+*".*+,/.-,.*$(-)/,#.'-.).*//.+-//-%././',),"..*.-+/--,-(*''+.'..././*-$.-*/-*/.///(,.)(,,./-,+)-)-+$."*+,-#,-$'.)./-"/+&//+-+*/.(,%(,..+./(./,..,'..+)+-,+('&'())))&----+,.()..-)&+#)(,&/././//.*...&-#//.+,&./......-+,.&)-"$#..+)*+&&//+//.+/."/-,*-(*-*++*)-"((.-..*,-$$#.-(''*.%.-/.,%*"+)..(.,*/)&,.)**.+.-.+/.//.+/*//%///*/,/./&.,/..////.//#/+%//++-'..*'##+##,&"&-&.#/--,,*/*-/..(*)-"-.,+//.#////,.*"/,,#$#...&,//.//*#//,../.-/.////*//-/+/-+,..,&(./##.-,,,/.*,/.#//))//*....-.)../.&*).*-.#.////,/.+,/$+.%/.*/,,+)///+./-+/,,"../-$/,,.(/***/.&-../-/.+*-+///--,.%##!$&-.-".,"/.,,.-''-*,*#.$,-,/*/.-#////)/*.-.+/&/&+,--'+/+*)-)//.,/#-*-//.///.."+/.$//../".,///.+*/#+-*//..&,+#,/--,-),--&.-///-&/+/-"/)//%-*#./.+/&.$/.,#+/////+,#.///././'/./-*-.+//--//,,''+,+)/*.-,+///.%",.+*///&$./../-/,+/&--,/(-.../#"//-//..//./,/$+//.,*(*-..",,,.(/,",,"/.+/,,,#*,////.--"'.%)$...)-,$,//+."&(/*,...+$&.(+.+/.//*'&#.&-+,)/,"."/,-),//+,//-/.%'+-+'%'',.-..+/.+-//).+/...#./..*(./-///..././&&/+//)//-*-'/-&,,*&.'*//-/+-...."+'--,,-+///.,../-/--*-%,-.$#,-,*-/.+...$//..)&%)-,,.-$/-./---$).-+/-&/&*/)-.//.+.(,#%#&&--#-$//+,-#/,*+"&..","*)./.,.#-/./.$#///*,,//+-//*.*/.-//&/.,#(/---*,./../%/)&&'&&///.//#)*+)/-//..-/////,.//-/,.-+.(./..--//+$//,.//.*,+/*-+,/.!/-)/..,-//-./,-,,).-/.*./.../*-,,+).+*#.."/-.////..+//%-,-/$)*//+.#//-///,/*/.-+/'*///&-..*,/.#"-//"%**"+'&/////.'%,-*.///../-/#./-+//#-#..,)/."////#.,/'...'%(#&$*.+*/."-+.-//-./"--*/,-/-+/.$/%,.#%/./.+,,,,)..+.%..",*%//,/"-$..-'---#+. @rCer/141/25_1777_CCS ATGGGGGCCGTCAGAGCCGCCATCTTGTGGAGCGAAACCAACGCCTGGCTCGAAGCAGCAGCTTCTGAGGTGTCCCTGGCCAGTGTCCTTCCACCTGTCCACAATATGGGGAACATCTTCGCCAACCTCTTCAAGGGCCTTTTTGGCAAAAAAGAAATGCGCATCCTCATGGTGGGCCTGGATGCTGCGGGGAAGACCACGATCCTGTACAAGCTTAAGCTGGGTGAGATCGTGACCACCATTCCCACCATAGGCTTCAACGTGGAAACCGTGGAGTACAAGAACATCAGCTTCACTGTGTGGGATGTGGGTGGCCAGGACAAGATCCGGCCCCTGTGGCGCCACTACTTCCAGAACACACAAGGCTTGATCTTCGTGGTGGACAGCAATGACAGAGAGCGCGTGAACGAGGCCCGTGAGGAGCTCATGAGAATGCTGGCCGAGGACGAGCTCCGGGATGCTGTCCTCCTGGTGTTCGCCAACAAGCAGGACCTCCCCAACGCCATGAATGCAGCTGAGATCACAGACAAGCTGGGGCTGCACTCCCTACGCCACAGGAACTGGTACATTCAGGCCACCTGCGCCACCAGCGGTGACGGGCTCTATGAAGGACTGGACTGGCTGTCCAATCAGCTCCGGAACCAGAAGTGAATGCGACCCCCTCCCTCTCACTCCTCTTGCCCTCTGCTTTACTCTCATGTGGCAAACGTGCGGCTCGTGGTGTGAGTGCCAGAAGCTGCCTCCGTGGTTTGGTCACCGTGTGCATCGCACCGTGCTGTAAATGTGGCAGACGCAGCCTGCGGCCAGGCTTTTTATTTAATGTAAATAGTTTTTGTTTCCAATGAGGCAGTTTCTGGTACTCCTATGCAATATTACTCAGCTTTTTTTATTGTAAAAAGAAAAATCAACTCACTGTTCAGTGCTGAGAGGTGATGTAGGCCCATGGGCACCTGGCCTCCAGGAGTCGCTGTGTTGGGAGAGCCGGGCATGCCCTTGGCTTTAGAGCTGTGTTGAAATCCATTTTGGTGGTTGGTTTTTAACCCAAACTCAGTGCATTTTTTAAAATAGTTAAGAATCCAAGTCAAGAACACTTGAACACACAGAAGGGAGACCCCGCCTAGCATAGATTTGCAGTTATGGCCTGGATGCCGGTCACCAGCCCAGCTGTTCCCCTCAGGAACATGTGGTGGCGCAGAAGACCGCGATCAATTCTGCATGGTCATAGTAGAGATCCCCGCAACTCGCTTGTACTTGGGTCACCCTGCATTCCATAGCCATGTGCTTGTCCCTGTGCTCCCATGGTTCCCAGGGGCCAGGCTGGGAGCCCACAGCCACCCCACTCTCCCGCAGGCCGCCCCACCCACCTTCAGGCAGCCTATGGGACACAGGGCCCCATCTGTCCCTCGGTCACCGTGTGGCCAGAGTGGGTCCGTCGTCCCCAACCCTCGTGCTCGCTCAGACACTTTGGCAGGATGTCTGGGCCTCACCAGCAGGAGCGCGTGCAAGCCGGGCAGGCGGTCCACCTAGACCCACAGCCCCTTGGGAGCACCCCACCTCTGTGTGTGATGTAGCTTTCTCTCCCTCAGCCTGCAAGGGTCCGATTTGCCATCGAAAAAGACAACCTCTACTTTTTTCTTTTGTATTTTGATAAACACTGAAGAAGCTGGAGCTGTTAAATTTATCTTGGGGAAACCTCAGAACTGGTCTATTTGGTGTCGTGGAACCTCTTACTGCTTTCAATACACGATTAGT + IH(KKKF?KGJJKKJJEKKFKIIFFJKK(IFGJI$IDIK;KJJ8KK>KI?HJ8JKH8HGGGIHKKHJJAJ;DD*JKGHJ@IKJHJJGKIJFKKDKKKG;>?>%D;GG&JB?A@IH>?>FB@CEGH:B>@=II7H/FKCG)KGK62KH%KKJJI:8DHFJKJJIJEK@IG?GIH-HH;JJGKBIKKJKK/KKK2K?FCKJKFF:=JEKJJKFKIHAKHKJJJAKJDHGHFDFHJJD8I9DGB=G%@C<=IAG=;JJ5GF6KJHKKKJJICJGGAD0JKFFBG?KIC?KH1EHHIFJKGI3@@JKIJ4FAG&GIIJHHJHJKIBJFEHKC=FFK;KKKEEKK@KICJKIJKK;JG@KJHKJJ6GKJIGKKIJ(JJJGAKJKKEIKKJIGK>KJKKKKK@JKJJ2KKKKKKCHGKIBIHFEK0KKKK5KKJDIKGGKHKKJKKKKK@KJKK;IKI:K@KKHKKKEK>KKKKHKKKKKKGKK?KKKKKJKIKJAIKK>KKJDKKBKKKJKKJK;KHK,FKKKHK@KKJKKKKKJKKIJ:)@KKKK>KKKKKKIK@KKIKKJKFKKKKJKKGKKKK?KKHKIJIGJIK:K:KKKB@(JGKJ@KGKKKIIKG=5KKJKKKHKKKKKDKKKKKKKDK8IKKKDKKKEKKJJKKKHK&KKKKKKIKEKKGKH/FKKKHJGK3JKIKKIKIKKAKKKK,KEJ7K=KHKKKKKKKKKJH>KKJJIKKJKKBKKKK@KKKK;KKKKKKKKKJKKIKJJKIKBKKJCAKKIAKKIKKJAKKKAKEKKKKJK?KKKKKKK.KK4KJKKBKDJKFK?K:KKGKKJKKHK8KKK/KK4KKKHKJKGKKKKK=KJKKHKKKJIKK@K>K:K:C8EJIGHK-KKKHKKKKKKKKDKKKK @rCer/142/25_2693_CCS ATGGGGGCAGCCCGCGCCTCCTCGGCCCGCGGGCGCTCTCCCTCGGCTGCGGAGCCCCAGACCCCGGCCACACTCGGTTCGACAACCCCAGACCCCCGCCAGCTGCCGCGAGTCTCCGCTGCTGGAATCTTGTTAGCGGCTGGCTTTTTGGGGGTTCTGGTTTCCCGACATTTTTGTTTCCACCCAGGAGAGGATATCGTGATTTTCCCCCTTGAGCCCAGCTCTGCTCTCTGGGGGGGTGGGGGGCGCTCCGAGCCGGGAGCCGTGCCAGCCGAGTCGTGCGGGCTGTGGCAGGGAAGGGCCACCATGGATGTACTCGAGCGCAGAGGAGAGAGCCGCCCTCGAGCGGAGCAAGGCGATTGAGAAACCTCAAAGAGGATGGCATCAGCGCCGCCAAAGACGTGAAATTACTCCTGCTGGGGCTGGGAATCAGGAAAAGCACCATTGTGAAGCAGATGAAGATCATCCATGGAAGAGGCTCTCCGGAGAGACGTGAACAGTACAAGCCTGTTGTCTACAGCAACACCATCCAGTCCCTGGCAGCCATCGTCCGGGCCATGGACACTTTGGGCATCGAATATGGTGATAAGGAGAGAAAGGCTGACGCCAAGATGTGTGCGACGTGGTGAGTCGGATGGAAAGACACCGAGCCCTCTCTGCAGAGCGCTTTCGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCAACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTAACTGGACAGCCTGGATCGATTGGGGCCGCGACTACCAGCCCACCGAGCAGGACATCCTCCGAACCAGGGTCAAAACCACTGGCATCGTAGAAACGCACTTCACATTCAAGAACCTCCACTTCAGGCGTTTGACGTCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCGTGTCGCGCTCAGCGGCTAGACCAGGTGCCCACGAAGACGAAACCACGAACCGCATGCACGAGTCTCTCTGCTCTTCGACTCCATCTGTAACAACAAGTTCTTCATCGATACCTCCATCATTCTCTTCCTCAACAAGAAAGATCTATTTGGCGAGAAGATCAAGAAGTCGCCTTTGACCATCTGCTTTCCTGAATACACAGGCCCCAATACCTATGAAGATGCAGCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATATTGTTCACATGACTTGTGCCACAGACACGAATAATATCCAGGTGGTGTTCGACGCCGTCACCGACATCATCATTGCCAACAACCTCCGGGGCTGCGGCTTGTACTGACCTCTTGTCCTGTATAGCAACCTATTTGACTGCTTCATGGACTCTTTGCTGTTGACGTTGATCTCCTGGTAGCATGACCTTTTGGCCTTGTAAGACACACAGCCTTTCTGTATCAAGCCCTGTCTAACCTACGACCCCAGAGTGACTGACGGCTGTGTATTCTGTAGAATGCTGTAGAATCCGGTTTTAGTTGAGTCTTCACATTTAGAATTGAAAGGAAAAAAGAACATTTCTCATGTGCTTTGTAGCTTAAAAAAAAAAAAAGGAAAACTCACCATTTCATCCATATTTCTTTCTTTTTCTTGCAAAACAAACATACCGTCTGCACCCACGCCGGCCCCGTCCACCTCGCGGCGCAGCCCTGGCGCTCCTGCTGGGGGGCAGGCCCATCTGCCGCCTGGGGTCCCGGTGCGGTGCACCGATCCGAGGAGTGTGCTCAGGCCGGGCTTCCAGAAGGCCACAGGCCCCTGCAAACCCTGCTGCCTGCCGGCCGCCCAGACACCACAGACGCCACCTCGCGCCCTAAGCCACTCCCGCCACATGCTTACTCCAGGTTGTATAGAAAAAGCACAGCTCTCACTGGCCAGTAGCTGCCAAAAGAACACCCATCGTATATGGAAATCCAGCCCCATAGAAAACAATCTGCCCACCAACCCCCTTCTACAGATAGCCTTGTGGGGTTTTGGGTCTTTTTTTTTTTTTTGTCCTGCTGAGTACTATGTATTACACCCCCAATCCAAGATCAGTTTTCTAGTCTTTGGGAAACGGGTTGTGGTTTTTTTTCCTTGCTGTGTTGGATTTCCGGTCCCGGCTGATACCCCCCTTCGTGTGTGCGCCCCTCCCACCTCTGCCTTTGTTTCGGTGCCCTGTGTCCGCCTCTCATGTGGGGATGTTTGTGCTGCAGACAAAAAGAACAAAAAAAATTTTTAAATACCACAAGATGGAAAAAAAAAACACAAAAAAATTAAAAAGATGGAATGTAGTGTTTACATTAAAGCCACCGTTTTCATGACCAATCCTATGTCATTTCTACTTTGACTAATATCCAAACCCCAAACCTCTTCACGGTTTCACTTTTAAGACTTAATCTTTGCTGAAGAAGACCAGTCACAGCCATTTCAATAAAGAGGAGGCAAAAGACAAAACACACAAAAAATAAAAATAAAAAAAAAAAGGAAAAAAGAAAAAAAAGCCCACGGGTCTTTGTAAGCCTTTCTATTCCCAATCGGTGAGGTTTCTGTGATATCTTACACACGCCAGTCTACTTCTCTGACTAATGGAAATTCCTGTGTAGCTCAATAAAGAGAATGTTTGTC + ''%')(++,)(*)**'+-&&*-,,-%**+,%,(+&$"&''**))'-%((+-.-,(--,#'+(+*(%**+,,(+(($()--*((##%%-+&'$$)++)#%&'))--(-'+-*+$,)$*)((+$%))&)(,)+#%'()+,-+('+)#,,*&"%))&$)*&&*%+-*-.-,,)%*'&%+&(*#$'&--,(*'$+&*''((+-)+)(,*'#,,,,,-+)('-+%%+,'''((-(-,%*&$(++)),,*,-*)&%(-+%&*)$('&((,,)+),,-),+)*---)),$,*()*-,,,(%+,(($-+&**&+%$%)*--,)-)&$----,(),,--,,-,-)--)-'#*,*--)-),-)+(-,()*-)((%-*'-))#)&(-(*,)(.-)),'-,,(,')-&*(,--+'*'(&')*,*,-'+-,%(,,+,%*#('(,-+*$+))(--(-*,.--,),,-,)-+'%)&)'((+'++)#(+(,*"'$#*+'&))*)%+1/)(/),-11-+-*0*&-+.%+$'$,0-++1),01+1*&(&-/,+1,--.1+0*10,',-*-&)-02/1-,%'%+#()%*/0.--,-2(,(*1,10&.-02001.%.+&-+-+)0,,1'/+,-((0)+*-111*$+)',-.0/2*,',#*+.0/-/'(-%'--%+,.'*-0-10'$,),+"%,,/-++**,0,+*0.+-,0,,/+-'/)/,,%(/*/-01/---0,.2+2,1*&+++2/)*1-.0.,'&-$-,.,+&.+%'*%/*)*,+$"(+),,).-,-0%,-,+%-.,%+,))/,#*+&,/-)/-),11121,--0+0)-0+,,002,12+,*',))-#++*#()(%%-0)((,&--,.*-+*..120'0*$.-'+/'0,3('.11$/,00//$,450*0304-.//3.1.4650)03142.53523$3,1165.2632620.4545,21//464,/2/65/1+)//12(*0/)/2.3-33.3.43,.%*&+(&#).+$')1)+..2+'&,/0.+/-'3*+5+*-/4)0+,..+++)/%,/0-.30651)*2.04/21,..)3(--4&+.(+)*)*-./5*(%,03/3,$-344*544/0,42'3-,65640235+33'1452.%0/2*/0,5*3+05),1%-441*0.11292'.28571'5/'-/(.-316940988799/4.3:9044303.,*+322234143552)748(789+548:.9:::56::724-.6493.:9,,85(/34+(2$1+/)+.4366670(-81642342&2*-29:-5&-895:1,23--697.4,/6644(.:5-..487.75.547;8;449060+.&.2542.3+/4'/2..)/1*163/&-,/.2,1'*%.23+/15/5055369258+7.+22561'4%3687559557:7&13528615-/83-64.55457$32465/7(76('1,144249761:-33764,206054%9856-,80;6;665/4,20745./0064.421%.-/1,+.'$112+'2421752,734:7812987)386383;9/1/.+41114./7/242%866?932&<===8,&7<;1=968/+&'-*8(::;<8:8)'#87769:9;;9:7.2)9:977343810/:542/6463-7:6,464)5268,+275/66:3$/04474'81-55223.95(,313*6%753/$#../6.88706156152:81077331.:514&$66874-'$8$)4229356;:+821:::55:9,41/7445942/443'2980'380423/56,3497;%724'7-.3/49)7-6:86&2&852268/97/9:136-816..17&.114/472*344475949947693281752&+9915:3082-&,977*)-.-412/88-,16(*.'10.2143'6450/656:993*'3639871:*212471238(7352,2.79;;:41880%1312)640///5'4424446,7778'463.-095428&2-9:2&%523,898955215)2--07:3#/--%1-+3+455445544240382-6-5/.8,14/-/.(+,+&3-1'/77::/4(/5-739744*&68)&,*/+5&226;;0579*83(1*(25$7632441,0(,28/144.0'7+/3120,22,80/4359592%/05642529+74619691:02.+9410296-.*4$214.56.*3,989713856140&%3325-(,%%46543-,4761'3/7:0&19%74/22250#-)01..*&,42(&/64429683:-5.'/$677777/.--+3&55442,+7&./,/03-/7&6%61'5.3-22184)7)441*4+'35%0435+4776:.3326'1',514(781545/3992/,-794465*88,5.4+331713&,-2404,472--$0/1-7,47.7+00928:::.-273%1+74:14.4022.11/$-/1)30&7:2/.54366&998477&88.77913++952/1%22///&741588777,+0&36576,%03.0488922927*6446(253575.7;*37/).-87;;3:5542440-4(7621585-4675&-+-4868)2:49-)36-495/4-4270/7112).1#)*/.211521021)0.'14255%0/4*2233% @rCer/145/1181_46_CCS GTTGCATTCAAGAAGACTTTCTCTTACGCTGGGTTTGAAATGCAACCCAAAAAGTACCACAATCCTAAGATCGCCCTTTTGAATGTCGAGCTCGAGTTGAAAGCTGAGAAGGACAATGCTGAGATAAGAGTCCACACAGTTGAGGATTATCAGGCAATTGTTGATGCTGAGTGGAACATTCTCTATGACAAGTTAGAGAAGATCCATCATTCTGGAGGCCAAAGTTGTCTTGTCCAAACTCCCATTGGGGATGTGGCCACCAGTACTTTGCTGACAGGGACATGTTCTGTGCTGGCCGAGTACCTGAGGAGGATCTGAAGAGGACAATGATGGCGTGTGGAGGCTCAATCCAGACCAGTGTGAATGCTCTGTCAGCAGATGTGCTGGGTCGATGTCAGGTGTTTGAAGAGACCCAGATTGGAGGCGAAGAGGTACAATTTTTTTACTGGCTGCCCAAGGCCAAGACATGTACCTTCATCCTCCGTGGCGGTGCCGAGCAGTTTATGGAGGAGACAGAGCGGTCCCTGCATGATGCCATCATGATCGTCAGGAGGGCCATCAAGAATGATTCAGTGGTGGCTGGTGGCGGGGCCATTGAGATGGAGCTCTCCAAGTACCTGCGGGATTACTCAAGGACTATTCCAGGAAAACAGCAGCTGTTGATTGGGGCGTATGCCAAGGCCTTGGAGATTATCCCACGCCAGCTGTGTGACAATGCTGGCTTTGATGCCACAAACATTCTCAACAAACGCGGGCTCGGCATGCCCAGGGGGGCACGTGGTATGGGGTGGACATCAACAACGAGGACATTGCTGACAACTTTGAGGCCTTCGTGTGGGAGCCAGCTATGGTGCGGATCAATGCGTTGACAGCAGCCTCTGAGGCTGCGTGCCTGATCGTGTCTGTAGATGAAACCATCAAGAACCCCCGCTCAACTGTGGATGCTCCCCCAGCAGCAGGCCGGGGCCGTGGTCGTGGCCGCCCGCACTGAGAGGCACCCCACCTGTCACATGACTGGCTGGCTGCTGGGTGCACCTACTCTCCTTGGCTTGGTTACTTCATTTTACAAGGAAGGGGTAGTAATTGGCCCACTCTCTTCTCATTGGGAGGCTATTTAAATAAAATGTAAGACTTC 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'/-30)31851/-).)444(-0/3,31,4531+68*06:.232/1514033-')52-.418326425(,+30.-6,625&390,8,7.5/620+1,//4'--4,3.0,&&7.372%3626353.2*-)15*648412735,335$10-/*5.1-012+-0+-763/8224477)00113'5,.4.3.,0/3,.'*)63/+53-90-56152-1$(+#$4/-.(+7975/52.2626.+(&*&%--&,4.*1$//4)('$0%/*-1010$4-534430-()83456.455(./+-/-0.152.-.6849054130,(-+#$%*'*-6.0+12-.-(/.00)-,-/0,-+4+2*136604(./2,446./624*42(..%(5*17/3/2(556'03/--*%06+1+'2/*+,-4334+3.)6+04-.%"#$&$'-&+***30+.2%/(/.+.0)/0$2$10(/),%++(#*/)117.53(408365065.5/2&21),()*()/*3+6(--'.4*02800.4/(34/)/*+/10122,0'*2784*6%(/16..2/$.)**,-&+11+02-0-44752/8,447,*'%)626&./)9)060-(235+833,2/,&)-1((6/,54.14*/3*4424-4/633&&,57%'41(5,46/.*+*-$+1.*021&.'+/0,7,+*2-6+1+829760,0+)/*0159&/5,2603=43.2(51/3<8873.-4:451,(12**&.-796996;7'#,4(4)36580,,4252,10---2&::26./).222'#'9:.41.764*7703*84+82..)607;65677:=24-<371219::;4=943,92312-1*8146-51%85=3,:80;374:7:9769=:098883;573:=845003521/07:74;23376872640(68/42'/89<354<93016;151,684030.7);70)888;2946/,)+'*.8689298.624;96:8-+1//4/5-8755;/091<8,28*29:7:3=7578.;-<8743*0/0+54450119786131/559*2024466).23,10225-//-$8*0*.389:3.)05&/40.534'(./-0+69)%1+55:/7.7=25<:707770095-3'/ @rCer/146/1083_62_CCS CTCGCCAGTTTTGCTAAGTCTTGATTGCCACATGTGATAGACAGTTCTGTGATGGAGCAAAATCCTTGAGAAGTGAGCCAGCGCTAGTTCTTCAAAAGATGAAGACAAGCGCAGCAGTTTCAACAGAGGAACCAAGGAATTAATCTTCATCATCTTCTAGAAGAAGAAGTGAATCAGCAACTGATCTTATTGAATTCCTAACCCAGGACATAACCCCTTTGGTGTCTAAGGCGGCATATTTTCTACCGTCAGCATCAACTTAAATGGTTAGGTCGTCCTCACAGCATGACCCAGTTGTCACCTGCAGACAGCCCTGGGGGGACTTTGAGTGACTTGCACCTTATCCCAGCAGGCTCCCAACTGTCTCAGGCAATGGAAGTGGATGGAGCTGAATGACTCTAGCAAGCAAGGCTATTCCCAGGAAACCAAACGCCTGAAGCGGACACCAGCTCCAGACTCTCTAGGCCTAGAAATGGAGCACAGGTTCATTGATCAAATATTGTCCACCTGTCGGAACGTGGAGCAAGCCAGGTTTGCCAGTGCATACAGGAAATGGCTGGTTACTTTGAGTCAATGAAAGAGGTGAATTAGTCCTACAAGGTTCCCCTTTTAGTGCAATATTGCTTTCTTTTATTATTTACATAGTTGGCATGAACTATTTACTATTATTGGCTAACCATATGTTCTTCATCTTTAGGTTGAAAGTCCATAGTAAATCTTTCATTTATTTTATTTTGTTAATAACTGGCATTCCTGTGGGGATAAAATAGTTGTATAGTTCCTTCGTGCTAAACAACGTGTCTTAAATTTTCTGTTGAAACTTCTCACCCTTTGTATTTCTGTAAGTGGGGCTTCTCATTTGGTTTTTCCTGATTGGTTCACATACACACCTCTACCCACCTCAGTCCAATTGCTGCATAGGCAAATTATTTTAAAAATTAAAAATTTAAGGCAGGCGGAGGATCTCCTGAGCCCAGGACTTTGAGACCAACCTGGGCACACAGCAAGACCCCATCTCTAC + #"$%%%$%%$%$%$$"""$$$"$$#"$%#"""#$"#$#$#$%()(('#%%%"'&&##%&(($()&$$&%((%$%$()&((&())'%$%(()&##&($(&%&)((($$$'$&"#$'%(%%#''#'()&$#)()))((('$)&)('&$%((&(((((%(''('%()'$)''%(&'#$&$'#"'%$$''&('&$($$)%%#''#%$%(%'$$%$$$%''%'%#(',-,&%)',())+)'(*+,+%+-+-'"((#%)(++'#)('')'),'$$',,%'#$1-.-*&/))&-,111+.--'1101+**,10+.,,02,/%'(*/-'001/,..+$*,+0+)'(/,0)0,(.*)+-'*,+%,0(*0+/,0../(00.0-02,-)112.'*..0%01,,,10,-)+'*011,110*0,10+/)+-&0/'-,)++-.+-/1-0.1*'+%+---++-,102.-1,/.-110,',-*1./+,&/1,/,0100.'.*-1..*,*0-,*'&$++&%*,-112..212.,1,0-/'.0+,20-0,//+/0+).*',+)+.-21021,1,,/0-0,++00(01.011-*,.1----+11.)/.,101*&/*/+101(*-/(*)*&,,10,*$,1/*%,---+0/0(+0)*11,/*,+000**%-,-.)-.0-12*1,*++-1.-)(--1,/1+')0+'#)('/+,+)+&/...&-,)(**1-+**00,.)-./0'/+-($+//((.//0&01)+++,).100'+0+.0-0,/-0+++-,*&%)',-+'*-+..+.+/&,10(+'+,*-0)0*.-+,1-,(*/21.+&020,)/'/+'--/).1(.1)..*.'('(*(*+,((,0$)2-1,()*+(1,*+0/%.11,/+*.)2/0)$#$)*,,('##$&,..,(-*)-,-,.)&$-)((('++,*&''-,)-+'&)+$')-((.*+,(##*"$-,-)"#)&"&),(',)---*,+----),-))'),$,---$&-(--+,-&'#'*('(+(#"&-,-(*%$(*(,+ @rCer/147/24_2166_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT + KKDKKKJIKKKKKIKEKKHKKKKKKKKKIIIKKJKKEKKKKKKJKIKKKKKKJKKHKKKKDKKKKKKKCGJFKKJDKKHKGJKKKKKKIKKKKKJJJKKKKKKKJKKKKKKKKKCK>KJK?KKKHKDKCHKKJ6IKK=KIKJCKKKKJKK=KKFKJKKHGKKKGKKJKKEKKKKKK8KKCKKKKJKGKKKKBFIKK)KKKJJKJKKK2KK0KK(KKKFJJJKKK5KKHKKHKKKI@DCJKKJKKK+KKJFGKKAKCKKKCK@KKJKJKKK(KJHKKHIKJKKJKKKKKKKKKKKKKK>C;AAKKKHKEKKKK9K?KKJ;KECKKKKJKK;KEFJ8KKKFKKIJKKKDKKJKKKIK:KKKKIKKIK,KKCJKKKKJJDKKKKKKIKKKKKKFHKEKKHIKKJJKKJKKKJKKKJJKIKHJK@KKFJKKJKFKKKHKKKKKJKIKGKIKKKK>KKKJKK9KKKKKKKKKIKKJIKKJKK7KKKJKKKJKKKBKGHKKKKHKCFIKKK:KKKIJFJIIKKGIKJJIKIKKKJKGIKI9KKHJKJHKKKAKBKKKKJIKKKKJIKKKKKJIKKHIKHKKHKECKKKHI9EJH>KH9CFJIDKJKJC)IKKKKKIKFKKKKKJK:KKI&HIIHKKKKKKKKJKKDKIKKJKKHKKKKD=JKKFIHKKJKKI6KKKKGKKJKKKAKKFK:KHJKJKKKKJJKIKJKKBKKI>IKKIHKKKKKK9K%ICGKHKKKKKKDKJDJ=KK9HGGF5KKKIK4KHJJKKEKEKKJKGIKKIKFIKG=KKKKK2KKKIKKKKKGKKJKD7JKJKBKKK?KEKKKK@KJKKKKKKK:KKJCKKDEKKKKKKBIKKJKKKKJKJKIKKJKJI;IKJJIKKIKKCDGK6KKKKKKKKJKKEKK=IKIKDJKKKKJGEKKKEKIKKHHK>KJGKKIJKKKJKHHI;KIKKHKKCJK9KKJKKJJKKKIKFK(KKKKJFCFJGJKJIKIKIGJIKICKJKKJCJAJ?HAKJKIKKKKKKJKJKKIKHKIIJGDK5GHKIHJJKI6JH92JJAHIJKKKKKKKEKKJFA-HJKK.KKKGKKKKIAKKG6JCHJDKJKEKHK/IKKKK6KKKKIKH@HKKJKJHIKKJ(KKKKJBKGJJ?KJJKKKKKKKJGKKKIKIKKKJKK72'KKJKKJHJGKI5I3GFHKKKIKKJHK5IIIKGKKK@KKBKJJJ9KKK>KFKJJHIGFGGJKKFKHKKKJJFGK1KKKKIKJJJKIJJ;KKJKIKGKKK=KK:KKKD@2KHKHJJKBKKFKKKKEIJ6KKKKKDKKKIEKKKKKHKIKKKKKJKKKJKKJHJGKFKDKHKKJKBKKKKKK7IJKKGKHKKKKHIKGKJKGKJIKJKHKKKJI@JKJKGKJJKIKIIK@KKKKIHGJKKKHBKKKEJKKKIHKIKKHBKKJKHK=@KKJ'I @rCer/150/1967_55_CCS ATGGGGGGGATACATCCTGGAAGGTTCGTGTGGGGCTGGGTCCCGGAGTGGGAGACGTGGAGTGCAGTTTGGAGACCCTGACACACCCACCTTCTCACCTGGGCTCTGCATATCCCCCAGCCTTGAGGGAAGATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCAGAGGAGCCCGCCAACGAGCTGCCCATGAATGAGATTGAGGCGTGGAAGGCTGCGGAAAAGAAAGCCCGCTGGGTCCTGCTGGTCCTCATTCTGGCGGTTGTGGGCTTCGGAGCCCTGATGACTCAGCTGTTTCTATGGGAATACGGCGACTTGCATCTCTTTGGACCCAACCAGCGCCCAGCCCCCTGCTATGACCCTTGCGAAAGCAGTGCTGGTGGAAAGCATTCCTGAGGGCCTGGACTTCCCCAATGCCTCCACGGGGAACCCTTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCCGGTGCGCACAGCAGCCTGGACATCGCCTCCTTCTACTGGACCCTCACCAACAATGACACCCACACGCAGGAGCCCTCTGCCCAGCAGGGTGAGGAGGTCCTCCGGCAGCTGCAGACCCTGGCACCCAAGGGCGTGAATGTCCGCATCGCTGTGAGCAAGCCCAACGGGCCCCAGCCACAGACGGACCTGCAGGCCCTGCTGCAGAGTGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTGCATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTGGGCAGTGCCAACATGGACTGGCGTTCACTGACCCAGGTCAAGGAGCTGGGCGTGGTCATGTACAACTGCAGCTGCCTGGCTCGAGACCTGACCAAGATCTTTGAGGCCTACTGGTTCCTGGGCCAGGCAGGCAGCTCCATCCCATCAACTTGGCCCCGGTTCTATGACACCCGCTATAACCAAGAGACACCAATGGAGATCTGCCTCAATGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCGCCCCCACCCCTGTGTCCAAGTTGGCCGCACTCCAGACCTGAAGGCTCTACTCAACGTGGTGGACAACGCGCGAGTTTCATCTACGTCGCAGTCATGAACTACCTGCCCACTCTGGAGTTCTCCCACCCTCACAGGTTCTGGCCTGCCATTGACGATGGGCTGCGACGGGCCGCCTATGAGCGTGGCGTCAAGGTGCGCCTGCTCGTCAGCTGCTGGGGACACCTCGGAGCCATCCATGCGGGCCTTCCTGCTCTCCCTGGCTGCCCTGCGTGACAACCATACCCACTCCGACATCCAGGTGAAACTCTTTGTGGTCCCCGCGGATGAGGCCCAGGCTCGAATCCCGTATGCCCGTGTCAACCACAACAGATGTACATTGGTGACTGAACGCGCCACTCTACATCGGAACCTCCAACTGGTCGGGCAACTACTTCACGGAGACGGCGGGCACCTCGCTGCTGGTGATGCAGAACGGGAGGGGCAGTCTACGGAGCCAGCTGGAGGCCATTTTCCTGAGGGACTGGGACCCCCTTACAGCCATGACCTTGATGCCTCAGCCGACAGCGTGGGCAATGCCTGCCGCCTGCTCTGAGGCCCGGTCCAGCGGACAGGCCGAGGCCTGCTAGGCCCCACAGACCCAGATGCTCTGGGTCACGGTCCCTGTCCCGTGCCCCCGCTTCTGTCTGCCCCATTGTGGCTCCTCAGGCTCTCTCCCTGCTCTCCCACCTCTACCTCTGCCCCCACCGGTCTGACGCTGTGGCCCCAGGACCCAGCAGAGCTGGGGGAGGGATCAGCCCCCAAAGAAGTGGGGGTGCATGCTGGGCCCGGCCCCCTGGCCCACCCCCACTTTCCAGGGCAAAAAGGGCCCAGGGTGATAAGTAAATAACTTGTCTG 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@rCer/151/272_58_CCS GCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATTGGC + &,021*-.5.-5320634..0&1696.15#99::0.9:1;144/636183::0.452+336;?>*3=88'@@6A=:6847686<;8?8:>:;<;;8/79C;B==>1;<1635@49=4C>CA<34A8@>5488&=>A=7=6B>9:9=25/+3-,-252)(3748972;38978;76/323/4<73789<4;(+=--1<=.>=>9968;1.=6<4> @rCer/153/2301_58_CCS ATGGGGACTGCAGCACTAGCCGTCTGCAGCTCCGGCCGCCACTCGCGCCTCTCCAGCCTCTGCAGGCCCAAACGCCACCAGCACCATGGCCAGCACCATTTCGGCTTACAAGGAGAAGATGAAGGAGCTGTCGGTGCTGTCACTCATCTGCTCCTGCTTCTACACACAGCCGCACCCCAACACCATCTACCAGTATGGGGACATGGAGGTGAAGCAGCTGGACAAGCGGGCCTCTGGCCAGAGCTTCGAGGTCATCCTCAAGTCCCCTTCTGACCTGTCCCCAGAGAGCCCTATGCTCTCCTCTCCACCCAAGAAGAAGGACACCTCCCTGGAGGAGCTGCAAAAGCGGCTGGAGGCAGCTGAGGAGCGGAGGAAGACGCAGGAGGCGCAGGTGCTGAAGCAGCTGGCGGAGCGGCGCGAGCACGAGCGCGAGGTGCTGCACAAGGCACTGGAGGAGAACAACAACTTCAGCCGGCAGGCGGAGGAGAAGCTCAACTACAAGATGGAGCTCAGCAAGGAGATCCGCGAGGCGCACCTGCCGCACTGCGCGAGCGCTGCGCGAGAAGGAGCTGCACGCGGCCGAGGTGCGCAGGAACAAGGAGCAGCGAGAGGAGATGTCGGGCTAAGGGCCCGGGACGGGCGGCGCCCATCCTGCGACAGAACACGTCGGGTTTCGGTTTTGTTTCGTTCACCTCTGTCTAGATGCAACTTTGTTCCTCCTCCCCCACCCACGCCCCAGCTCATGCTTCTCTTCTGCACTCAGCCGCCCCGCCCTGTCCTCGTGGTGAGTCGCTGACCACGGCTTCCCCTGCAGGAGCCGCCGGGCGTGAGACGCGGTCCCTCGGTGCAGACACCAGGCCGGGCGAGGCTGGGTCCCCCGGGGGCCTTGTGAGAGAGGTGGTGGTGACCGTGGTAACCACAGGGCGGTGGCGTGGGATCGCGGGTCCTTACACTGGGCTGTCTGGTCAGCATGTGCAGGTCAGGCAGGTCCTCTGAGCCGGCGCCCCTGGCCAACAGGCGAGGCTAGGGTACCTGCTGTCTTTCCAAGGGAAGGGGGCTCCCCATGCGGGAGGGGCAACGGGGGAGGGGGGGGTGATGGTGCCTGGGAGCCTGCGTGTTAAGCGGGAGCTTGTTGAACTGGCAGGCAGGTGGGTGGGGGCTGCAGCTCTCCTTAATGTGGTTGCACAGGGGTCCTCTGAGACCACCTGGCCTGAGGTGGACACCCTGGGCCTTCCTGGAAGCCTGCAGTTGGCGGCCTGCCTGAGTCTGCTGGGGAGTGGGCATTCTCTGCCAGGGGCCCATGAGCAGGCTGCCGTGGTCTAGAGGTTGTGGGCAGCATGGACAGTCCCCCACTCAGCAGTGCAAGAGTTCCAAGAGCCTCTGGCCCAGGCGCCTCGGTGAGACAGCCCCGCCGCCCTCCCCACCAGGGCTTTGCGGATGTCCTTGAAAGACCCGGCCTAGAGCCCTTTGGAGTGCTGGCCCCTCCTGTGCCCTCTGCCCTGGTGGAAGTGGCAGCCACAAGTCCTCCTCAGGGAGCCCTAAGGGGGATTTTGTGGGACTGCTGCCCACAGATCCCAGGGTTGGAAGGGCAGCGGGTAAGGTTCACAGCCACCCCCCACACCCTTCCCACTCGGCACCCAGAGGGGGCTGTGGGTCGAGGCCTGACTCCAGGCCTCTCCTGCCCACACCTTCTGGGCTGGGTTCCTTCTCTCCTTGGATGCCCAGTGCTGGCCTTGGAGGACGGTCATCTGGAGGACGGGGGGGGAGGCTGTCTTTGTACCACTGCAGCATCCCCCACTTCCCCACAGAAGCCCCATCCAAAGCTGCTGCCTGGCCATTGCTGTAAAATGTGAAGGGGCAGCTGAGTTCTCTTAGGACCCAGAGCCAGGCCCTCAGCTTCCATCCTGCGGAGGCCTTGGCAGGCACTGCCAGCGTCTTCCAGGGCCACACCAGGGACTATGGGAGGATCCTGACCCCTGCAGGGCTCAGGGGTCAGCAGGGACCCACTGCCCGTCTCCCTCTCCCCACCGAGACAGCCCCAGAGGGAGCAGCCAGCTGGGATGGAACCAAGGCTGCCACATGTGGCTTTTGTGGGACTCAGAAAGGGAAGCAGAACTGAGGGCTGGGATTCTCCTCACGGTGGCAGCTCTCATAGCGAAAGCCTAGTGTAATATGCACCCATCTCATCCACGTAGTAAGTGAACTTAAAAATTAATCAAATGAACAATAACACCTGTGTGTTT 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GGAGCGCCGGCCGCGGGAGCGGGATGGAGACCAGCAGCCGCCGCCCCCGCGGTCCAACCCCAACCTGGGGCTGAGCCTGGACGCCCGGCTGGGCGTGGACACGCGCCTCTGGGCCAAGGTGCTGTTCACCGCGCTGTACGCACTCATCTGGGCGCTGGGCGCGGCGGGCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCGCGGGCCGGGCGCGCTGGGCGCCTGCGCTACCACGTGCTCAGCCTGGCGCTCTCAGGCCTGCTGCTGCTGGTGGTCGGCGTGCCAGTGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCTGGGTCTTCGGCGACCTGGGCTGCCGCGGCTACTACTTCGTGCGCGAGCTGTGCGCCTACGCCACGGTGCTGAGCGTGACCGGCCTGAGCGCCGAGCGCTGCCTGGCCGTGTGCCAGCCCTTGCGTGCCGCAGCCTGCTGACGCCGCGCCGGACCCAGCGGCTGGTGGCGCTCTTGTGGGCCGCCTCGCTTGGCCTCGCCCTGCCCATGGCCCTCATCATGGGGCAGAAGCACGAGCTGGAGACTGCGGGCGGCGAGCCGGAGCCGGCCTCGCGCGTGTGCACCGTGCTGGTGAGCCGCACCGCGCTCCAAGTCTTCATCCAGGTGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCACTAACTGCTTTCCTGAATGGGGTCATGGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTGCCGTCCACTTCTGCCCTGGGCAGCTCTACTCCCAGCCGCCTGCAGCTGCTGAGTGAGGAGGGCCTCCTCAGCTTTCATCGTATGGAAGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTGGAGCCATCGTGGCCATGTATGTCATCTGCTGGCTGCCGTACCATGCCCGCAGGCTCATGTACTGCTACATCCCTGATGACGCGTGGACTGACCCACTGTACAATTTCTACCACTACTTCTACATGGTGACCAACACACTTTTCTACGTCAGCTCAGCGGTGACTCCTCTCCTCTACAACGTCATGTCCTCCTCCTTCAGAAAGCTCTTCCTGGAAGCCCTCAGCTCCCTGTGTGGAGAACACCACCCCCATGGAGCGGTTACCCCTGAAGCCCCACAGTCCCACCCTAATGGATACAGCTTCAGGCTTTGGGGATCCCCCAGAAACCCTGACCCGAATGTCATACAAAAATGAACAGAACAAGCAGAATGACCAGTTGCTTAATCATCTGGCAAAGCAGGTGAGCAGCCTTATCACTAATCATTCAAGCTTTGCAGCCAGGGTGACTTCCACCAACCCCAGCTCTGCTGAGAACCATCAAGTGCAGGGAAGCCACGTGACCCCTCCTAGCCTCAGGCTCCCTCATCTGTGTAGTGGAGATAAGAAGAGCACCCATCTCTTAGTGTTGTCTGAGACTAAAGTGCTTAGCACACAGCCTGGTGCATAGTAGATGCTCAATAAATTTTTGCTGG 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AATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCACATAAAACCCCCGCATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTT + &EF1HG69H=;FEAHH>@4FB:GBIEDG>%C=?D@;2BA>9>A)CF;HBHC4CBD>FFIC=D7DGFJEGGGFBE2GH>E4GD8:IEHHI?FI>G?BC+(:)<=:=B:.:7DAFB=C4HG?EEDF2ED?=@@6:@(9BAD&6:C@<@+99;>8@B/8:31*.4'?@AD;5DGFHIBF@IDIHBAFC:3BGIFCH?3H=64?CD5;D>E=BDAI6BC<6?GBGCGH@@H=FA;/FEAG=>8@>EEFBGFCCEDFIEFFIB=@1EG?8GIH'CBBH=G@GC??=HD.DH>;B62?9GIID3@F:HG4DDBIB?CA;>6=A?:>H>DDFDC>DC*EI.HG=I;E?B8=<;E>I8GB>G8IE28?C=>F@<=E>0?DDEH@?FF4GG=;=9?G?5C-;@H;A6>9A=6:;;B8BBCB$27:C?E5BDDCDF>8:<97:A<2(=8=FE>HH5CBEJHAG:GEEE6B1;??D@@>EJ?HF.@:-@(EE;EA,?A@D=DDE>:CA=@AAE>8C@?EHA7E?@9AAB8@?8&CGC>?A>H>FD4EB4AA<=;B7+GEBD99@;A<:B?:C45*<&,/A8C>D:E5->A;;<75$470=BEH>:=DHEBBC@GC6GE@C8=@C??;=?79:@>::@;C?DD<954B0DC7779;E*3;5385)=3.A>I?;C?>=8)8BAA>H@5HHAB>>J;H@=2FH;9F?;?ACA:2BF@EE=H@:D@IIEB=GI:HFFC:FH==(AB@?9H>A?CB70?2BDIEF7HJCC;FED;<@>=,#9==>E;%7:CCH?FE?7=>4C7D>F<8K=@H2FFJIE=CBHEFDDGCAC/B==AB.AA93>?DFFCG?G@E7HE9C;BB@8H(=AADJFID6>>:ECH@G?CC3?E;?FDIHF?-;8,BA9@A%::8&C;8>@EHB@:A2A@J<&:A75<;C=4@CD?HC(0HHHGIDBIH6E88E?ABABAEFFCIFA?KH@@H?HJCFH@IDJICGGHEIE@H?C3EI?DC2FBFI/EGHJC@9D:6;DH@AB=HHJHJ7IH@J?JKJHKCA@BCA?6<173:8;5@;736:036@=9<=A<>;><<>9>==AB997B8?A59075.:5@9:8362>5?=1=A9@/74:8<::6A;<=A7B><;;8;<.,'B57;;*6975/B?8@@79/=4+;<:??<=80:*99;>46%9=:+<=@<.;=?BA;3=@>97/6=<91963492?:?4?=;7<(:976B-==0?=>AA?A7:56;-:@?97=<@>@2?<3>:A4;A8><1<2177::C>B@&<9:074?=7>9A3=&449,$8687;;,81=C:=@6A?=:=::7/9?+56>99>@=4?=?A=:9.;6<:8>=;?9<1.=6882;<4?=B44'<=;3=>>79B@7A?00861<=<:>@><=B>;;51)3893-::3>>;>=?;79A=C8?976?8<=A?A=BA95:68CCA8&@*09:1?<>4<:3>8C>==>=:@;@A8?73:9;;8<6=6:=>47=4158=9A=?8@/1@;:0>82=5419996===6><;?AA2:70<:0==2791/12077>>)8;;::<928790:*,*:63=/@<;9@9(:,>@A==<787BC;C6=;=:8::7(25:&844=><6?;44-;2*6<5&2/5-+.8:;<7<;;64/6050370*'+7&/588;>8.,)1%*/79:0.39=835+76=)89691+-842899>45=7;817596/046';<99%49819/77<;.2.3=9557>9.3.2,35333325278882/87=66126;+547808=,88(8&3799(:::/.'-87:91677(1(2<;5;>(33885???=883:4:8.:=BA8C@?B@9A:;.35>4.8<79/?>3)1;;)9.('=;@>978<=9896,:9144%05<@ACB?>@EBBCGE23%>7/52(-))'5:8943881/:34>6;;<:6?AC4B7BC@??0A67>?+=;7A9=70==A*/52/@=A-%C8@>:@9$?<<5C1@6@,@777;8/<98-?.@?1;;B0DD?D@D6>426AC1D8398ECDB2=>9A)?DBF3<457D84D@7:?6:89:;CD@<<4235.:;E9C7;%@B=;E:=D59>A@E,1:AC?/>A0=6:@?AFE=98362=@5<<=27@@>@92;?=3CFA>C$=<47AE?E01=:C8E>%.66572?123;:2':5A/?<7BC6:'9?=+AAD0::AAEEA@B@EBB:B==?EFF7?+?=AC%9::<>=;@34:>1=4@>9=?7;GAE;BA<@F@AA>E874,-665#85@@5+<7-;/89:<;=3>=?96D=3'8)#;A>:&837;>AED5:?:A>;627<=824:0>/835:<=<@?8?4;ADA,E?E9=<:8;E0@9AAB=83*/28@7?AD><@>,;*/>1:8@G@BCF=:>>DECC@(6/=;ABCE?CGDCC=@D9-CDBA;12=6@8@>1>:*89CD=E0=2(2FF=5ACC>B965>90:;<=<3;A;)?5?<&79B%58;;@;(>>3:@3<@AB:6<531@6AA7:;4<65/8<AAA6/9+=?;D?69?=<1B=A9@B0A13->%665>FD<3:?8D53<9606@;?24?=:@;A?>9>C-@?=4=>8?;<3<7>96C:+<)-<*199+-?;B74FH<<;>BC;9;/@3D6 @rCer/166/2002_58_CCS ATGGGGGGATCGCAGGGCTCCCAAAATGGCGAGTGAGGCTGCGGGGACTCGCTGAGCAGCGGAGGGGGAGCGTGCAGAGCCGCTTCGGCCCTCACAGTCCGGAGCCCGGCTGGGCCGTGCCGTAGGGAACATGCACTTTTCCATTCCCGAAACCGAGTCCCGCAGCGGGGACAGCGGCGGCTCCGCTTACGTGGCCTATAACATTCACGTGAATGGAGTCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGGCCAATGTACTTCCTGCATTCCCCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACCCATTGCTTGGGAGCAGCGAGACCTTCAACAGTTTCCTGCGTCGGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGGAAGTGCTGCTCAGCAACGGGCAGAAAGTTCTTATCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCCGCAAAGCTGGATCTTCCAGATGACTTGATTGGATACTTTAGCCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGCAAGAGTTTGAGCTGCCTTATGTGTCTGTTACTAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTGAGGAAGAGTTATTGGGACTCTGCCTATGATGACGATGTCATGGAGAACCGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCACCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAGGTCTCCAAGAAGGAGTTCCTGAGACTGGCCCAGACACTGCGGCACTATGGCTACCTGCGCTTTGATGCCTGTGTGGCTGACTTCCCGGAAAAGGACTGTCCCGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGCAGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGGTCACCTCCTCTGTGCCATTGCCCAGTGGAAGCACGAGCAGCCCGGGCCGGGCCGGGGCGAGGTGCGCCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTACAGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTGGATGAACTGATGGTGAAGAAATCAGGCGGCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGCACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTGAGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCTGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAGATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCTTTACCCGTGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCAAGCTGGGGAGGGAGGGTCTTTTCCTTCTCCCTTCCTACCTTCCCCTTTTCTCTTGGCCAGGGGCCTTGTAATGTACCTTTCCTCGTCCCCTGGGCTGGCTGCACAGAGGATTGCCCCTTCTCTTTTCAGAGCTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGGACCATGGCTACCTGCCTTGGGGAGGAACCACAACTCCCTCTGGGCCGCTTCTGGCTTCTTGGGGCCATGGGCCAAAGGCCAAGGGATGGGCAGAGGTCTGTGTTTGGTCTGGCCTAGTTCCCCATCATTAAACTCAGCCTGATTGCTGCC + HKHKKKK/KKKKKKKKEKCKKDKKK=KKKKKKHKKKKKKKKKKKK.KKKKKKKKJKJKKKKFKKKKK1KKKKIKKKKKKK:KKKKKKKKK:KKKKKKKKJKKKKKKJKKKKKK>K?KICEJIIKJBEH9HICDFKHEHIKEKEICJKII.IFGDGHCDHGHJJFGB4KJIKCJKHKAIJIGHJFHCKJIJFBHGEII3IIE>HCJKJCH>EGCJKIDIFIJJHKDKIJ;IKJHCIIHIIKJEHGIKHKHHFE9JKHKC;B7HCII=I18?CEE:@E@BJBJ3IK@IFKIKJD=H,:JJKGIKI@KJGGGCH8I;D@K>HGAJFIA@HDH;5:FIH?JJ>JIKIGH>C>JIJHCGIKIKI=AKKHHJ?K@JAIIC-GDFFDJD?@GF;HG7HKAJI:CIJJKHAD;GDJHJJIAC<>BD-D@HGHIJ2JKKFIJGJ6EGFJJEICDE2JJEDEKBF@HHEKJ>HAHA5FGKIJFDCGBDJHCIBJHK?E?DGG,JGA=78HCEBJD6FJKIIDIHJJIGE@J>HB0=BHHJIJDFEHDFAGIB48FJJ8KFJIIG;IKEF7JKIJHJKKHFGGI?KFJEEHAGJKJE9G?KCIIFI>ICJJAIHKE>B9FGFEFKKKHIKIIGHI)JJJBHKCJCGC@EKKFJGEFCFJFHGFD,8KJK=FDIDDDFKDJHCGAG@IH.HJKJJH>70EF?HFECHGI@JGIED4IJEJFCGIIKBIKCJKJB@JJ>IIFKHG:JEHI>=DCH=EFJ7FHF?FE:FAJJGGFHCJKHIIG8FCEBHHCHJI+EIHH>*A>BAGJGDEHJGFH:JDIBIIJJIHJJCJK>HFGGICHCKKFIJFKKKEHGIDKHKK=>CI/ICBKGJ@KJGKJKJCKIGIFGHHK;KHGKIEHKIGJGABJK;KEBHFJGKKHE=H3HFHDFG=JED4FFEEJFIBD@,IHGH8HHF@HFE@ADHFIIG6DGC6FFF8DHGCB@EH@IHFA?DBCA;;@JGBIIBIHIEB@'DCJBC@9A=;@HFEIIJGCEJCH=FHCAFBE>C8EBG?HI5CFCHFEJJA>HD<>EHCG7FCBAAFC<9?EB7@HFHGHIG?IIHGBEC?EHCGEIG@AIH:H@DJJE>FDEGG0IEGI9CEHDAAGH<7BED>:G84=G?GACFGD>FCH>?=AAD?D7E?HHA7DGCF5DGHAIBGE:=;5GCBCF1AG>>9>A: @rCer/170/1907_58_CCS CCGCGATACTGGTTGCCCGCGTTGTGAGCAGAATTCAACGTGTATCGCTGCCGCGAAGATGGAGGGGCCTTTGTCCGTGTTCGGTGACCGCAGCACTGGGGAAGCGATCCGCTCCCAGAACGTTATGGCTGCAGCTTCGATTGCCAATATTTGTAAAAAGTTTCTCTTGGTCCTGTTGGCTTGGATAAAATGCTGGTGGATGATATCGGTGATGTGACCATTACTAACGATGGTGCAACCATCCTCAAGTTACTGGAAGTTGAACATCCTGCAGCTAAAGTTCTTTGTGAGCTGGCTGATCTGCAAGACAAAGAAGTTGGAGATGGAACTACATCAGTGGTTATTATTGCCGCAGAACTCCTAAAAAATGCAGATGAATTAGTCAAACAGAAAATTCATCCCACATCAGTTATTAGTGGCTATCGACTTGCTTGCAAGGAAGCAGTGCGTTATATCAATGAAAACCTAATTGTTAACACAGATGAACTGGGAAGAGATTGCCTGATTAATGCTGCTAAGACATCCATGTCTTCCAAAATCATTGGAATAAATGGTGATTTCTTTGCTTAACATGGTAGTAGATGCTGTACTTGCTATTAAATACACAGACACAAGAGGCCAGGCCACGCTATCCAGTCAATTCTGTTAATATTTTGAAAAGCCCATGGGAGAAGTCAAATGGAGAGTATGCTCATCAGTGGCTATGCACTCAACTGTGTGGTGGGATCCCAGGGCATGCCCAAGAGAAATCGTAAATGCAAAAATTGCTTGCCTTGACTTTAGCCTGCAAAAAAACAAAAATGAAGCTTGGTGTACAGGTGGTCATTACAGACCCTGAAAAACTGGACCAAATTAGACAGAGAGAATCAGATATCACCAAGGAGAGAATTCAGAAGATCCTGGCGACTGGTGCCAATGTTATTCTAACCACTGGTGGAATTGATGATATATGTGTCTGAAGTATTTTGTGGAGGCTGGTGCTATGGCAGTTAGAAGAGTTTTAAAAAAGGGACCTTAAACGCATTGCGAAAGCTTCTGGAGCAACTATTCTGTCAACCCTGGCCAATTTTGGAAGGTGAAGAAACTTTTGAAGCTGCAATGTTGGGACAGGCAGAAGAAGTGGTACAGGAGAGAATTTGTGATGATGAGCTGATCTTAATCAAAAACACTAAGGCTCGTACATCTGCATCGATTATCTTACGTGGGGCAAATGATTTCATGTGTGATGAGATGGAGCGCTCGTTACATGATGCACTTTGTGTAGTGAAGAGAGTTTTGGAGTCAAAATCCGTGGTTCCCGGTGGAGGTGCTGTAGAAGCAGCCCTTTCCATATACCTTGAAAACTATGCAACCAGCATGGGGTCTCGGGAACAGCTTGCTATTGCAGAGTTTGCAAGATCACTTCTTGTTATTCCCAATACACTAGCAGTTAATGCTGCCCAGGACTCCACAGATCTGGTTGCAAAATTAAGAGCTTTTCATAATGAGGCTCAGGTTAACCCAGAACGTAAAAATCTAAAATGGATTGGTCTTGATTTGAGCAATGGTAAACCTCGAGACAACAAACAAGCAGGGGTGTTTGAACCAACCATAGTTAAAGTTAAGAGTTTGAAATTTGCAACAGAAGCTGCAATTACCATTCTTCGAATTGATGATCTTATTAAATTACATCCAGAAAGTAAAGATGATAAACATGGAAGTTATGAAGATGCTGTTCACTCTGGAGCCCTTAATGATTGATCTGATGTCTCTTTTATTTATAACAATGTTAAATGGAATTGTCTTGTACCTTGACTTAAGTATTACACATTAAAGTACAACAAGCTGTAAACTTGGGTTTTTGTGATAC + /(-,1-*-002.52058283;<5:47>?8@>C>C??>1?>80:=>9@;55;4<4.968/:><:?@?79;??268@?=0160;?6:7>59808<=;?,?,>;89>@89=1A=2><@2@95:8:B4:28;42:-;36=<:&@>A<2:05/4(6)33&67<;/68>36*0C7:;418@;+<>5/7;:80,024BAA>@;3<85@?0)<2:BA>59:9;>;39761?::1<;;=C=?>7>B;:59863-=@:=:4=:9:5<>?:@@8=3068;+9?8<=A;B5>;A<3>2@A79<4:=>=;2:1:749==/6:2<;6:3<4>9>66-:6>C=B<::9=::?@CA*0><;,8=3=?@;>=78?=3>:>@A;3>1B?(=@:*A;9@=8;36;+98?A6=3@;===C:A>?/:87@9*@A89668?7469?:85,229@5=<:=6725;)9+-8;74<5@5:8:89>9<82@?=8C;=;93==<;672;2=(;:<:+<5>;=/=>?66539216<;<:;3380483090,225=:<>A>>8/,54704..---,39:2555385:;981;84;<38$>C>A@<-;?;:9:B,A?>;D=B;7;:95*+,>76?763+3;A;8(<8;>?D8D@;A:035;:;5:>?=A>9B>;A>;07<5D+'<@>A?A4D699?=4@CB=91?5@:6A:E@=BB98/?A?2>=61=149/*64=:C@==76699:C.)%&%-C89?>;7A=:B?>B>%8:A>@B=?6A?@@1;7*:0?ACD6FD=178359<%,5<::)@B>@A;<1AE3D92<99678?F;EFE=:?;9?69>@@D>;;<19B:?9=C<:<&;0>27>@;;ADB@8BA@EEGC?@4B9>>?98'F@C?BCC?C@3142<7EB@>=48;==+=?H?<=C0:5;4-8316&9D;:9898=2B8BEGF5I@BED;?AGFG624DECGFFHHF7CDE>>>FBGA=E8@I:DFDCGEFAG?@@CBABE>9DGFE?D??A>DHEHC@@5CDFE8HHCAB:E@JCF>?>4=BIA@BHDCCE+F?=B8>C6@CEDIBFBDCH>@I?DA@E?7E;GFEFFD;DC*@F7D:=F@66D(?BA=-5=ABC:>;@0FGC?D@E7CB=@D9CIIHED=DFB=>52C;@>9=G@B9D6E;HFIGE@IGEIIGBEEG6GI=DFC1EE5CCACE>BH?>E7FF6DDDBA;AC8B?I;GHDHCCH;GF>HFFDCGJD=89<6B>HFIDAD??C;8?EFE?B?A?7*=ABFBF>6>E3GHFED7A@G99B @rCer/171/1854_59_CCS ATGGGCAGAATGAGAATGAGGAGGAAAATCTTGATAAAGAGCAGATTGGAAATCTAAAACAAGAGTTGGATGACAAAAGCGCCACTTGTAAGGCATATCCAAAGCGTCCTCTGCTTGGACTGGTTCTGACTCCCACTCGAGAGCTGGCTGTCCAGGTCAAACAGCACATTGATGCTGTGGCCAGGTTTACAGGAATTAAAACTGCTATTTTGGTTGGTGGAATGTCCACGCAGAAACAGCAGAGGATGCTGAGCCGTCGTCCTGAGATTGTGGTTGCCACTCCAGGCCGGCTGTGGGAATTAATTAAAGAAAAGCATTATCATTTGAGGAACCTTCGGCAGCTCAGGTGCCTGGTGGTGGATGAGGCTGACCGGATGGTTGAGAAAGGTCATTTTGCTGAGCTCTCACAGCTGCTAGAGATGCTCAATGACTCCCAATACAACCCAAAGAGACAAACGCTTGTTTTTCTGCCACGCTCACCCTGGTGCATCAGGCGCCTGCTCGAATCCTTCATAAGAAGCACACCAAGAAATGGACAAAACAGCCAAACTTGACCTTCTTATGCAGAAAATTGGCATGAGGGGCAAGCCCAAGATCATTGACCTCACAAGGAATGAGGCCACGGTGGAGACGCTAACAGAGACCAAGATCCATTGTGAGACTGATGAGAAAGACTTCTACTTGTACTACTTTCTGATGCAGTATCCAGGCCGCAGCTTAGTGTTTGCCAACAGCATCTCCTGCATCAAACGCCTCTCTGGGCTCCTTAAAGTCCTTGATATCATGCCCTTGACCCTACATGCCTGTATGCACCAGAAGCAGAGGCTCAGAAACCTGGAGCAGTTTGCCCGTCTGGAAGACTGTGTTCTCTTGGCAACAGATGTGGCAGCTCGGGGTCTGGATATTCCTAAAGTCCAGCATGTCATCCATTACCAGGTCCCACGTACCTCGGAGATTTATGTCCACCGAAGTGGTCGAACTGCTCGAGCTGCCAATGAAGGTCTCAGCCTGATGCTCATTGGGCCTGAGGATGTGATCAACTTTAAGAAGATTTACAAAACCCTCAAGAAAGATGAGGACATCCCGCTATTCCCTGTGCAGACAAAATACATGGACGTGGTCAAGGAGCGAATCCGTTTAGCTCGACAGATTGAGAAATCTGAGTATCGGAACTTCCAGGCTTGCCTGCACAACTCTTGGATTGAGCAGGCAGCAGCTGCCCTGGAGATTGAGCTGGAAGAAGACATGTATAAGGGAGGAAAAGCTGACCAGCAAGAAGAGCGTCGGAGACAAAAGCAGATGAAGGTTCTGAAGAAGGAGCTGCGCCACCTGCTCTCCCAGCCGCTGTTTACGGAGAGCCAGAAAACCAAGTATCCCACTCAGTCTGGCAAGCCGCCCCTGCTTGTGTCTGCCCCAAGTAAGAGCGAGTCTGCTTTAAGCTGTCTCTCCAAGCAGCAGAAGAAGACAAAGAAGCCAAAGGAGCCGCAGCCGGAACAGCCACAGCCAAGTACAAGTGCAAATTAACTGCCCTGGTCAAGTGTGTTAGTGACTGCACATTGCTCTCTGTTCTCTGGCTATTTGCAAAACCTCTCCCACCCTTGTGTTTCACTCCACCATCAACCCCAGGTAAAAATGTCTCCCTCTCTTCCTCTCACACCCATAGCGGGAGAGACCTCATGCAGATTTGCATTGTTTTGGAGTAAGAATTCTATGCAGCAGCTTAATTTTTCTGTATTGCAGTGTTTATAGGCTTCTTGTGTGTTCAACTTGATTTCATAAATTAAAAACAATGGTC + KJKKJKIKKCJKKKKEDKKJKKKKKKK*HKKFJEJJKBHKIJKKJKIKFKKEFEHJKK@KKDKJJKJKHGKJKEKKK34E;K@KKJKF3HEJG9KKHCKKK8IIKKFC@FJ2IF>@KIIKFEDEJJK@?EKGIFEJ2KIJK<;HKEKIIEDJ38F5GEKIGKADKKJGH9GKKJD@IKADGDFBKKKKJKJJJKJKKHKDKJKDI;KJJIGKK?JJJKJJKKKJKAKJKKKDJ9FAKKKKKKDKKKIJJKKKKKFDK=EKCIGJ@KEKKJIKJC=4KKHJAI?KIII?EKAKIIKK'HJCFKFKK4H>IIEKK?=F>K?KEKKKKIJEHKIKKKECKFKKK;KI84KK+KKIKKK;JAIFJKJK?IKKKKKKKKDIKKJJKHKFKIJJKHHHIFKFKBIKKKKKKIKKI=JJIKIKJK@??JJKFJJ@JKIHKKJ8HJ@IKHIJD6GGJKKKIJGEEKHGGKHKKKFKKKEJKKKKKKHKKH@HHGBFF@K5H>KAAIG@@H0:GJKIHI9KK6KIJKKJJKKKKJKIKKKKKK-ECDH?HG><9;CDKK=II/GIJ:FJH4HJKKIJHIIIFKKBKKFDBAKK=ICJKKJH?KIJK8KFKJJKJKGKEKICJKIKJ=IJKKJIK=KKKIJJKKFHBKKKKKGKJKKKGJKFJKHKKFHIKKJIKGKCKKKJKCKKKKKIHKKHKGKK?KFJB=JKKKFK=FKGF7JKKKKKBKJKJKJF=GKAKKKHH5JIBIGIKHKIIKKIKKBKK?KKK3KJKKJKKJJJJDKJ@ICHKIKKKIKKHKIKH6KKKKIKHKGKKKHKKKKHKIKIJKJJCKKKKIKKIIJJKKJBD=CKKKAHJKKI=GFI9JBKJJKJJKKH0KBH-AIFKKKKKKJK>IKJEKIJKDAKHJKKKJEGJKFKEHJAIJJKK8KEIKKEKJKKKGIJKJDKJ:0IFCJKKKJEKKJJ>GKGII@EIFEIK9KFHKK9HKDJK@KH3KKEEI>JEFAKHKJGCKIGKFGJHKHJGDEJEKDJIDJGGJIKHEEK7GKKKJKIIHKDKIJE@KBKKIJKJKJ;JJJKKKKKKJKKHKGJHJKKHKKIKH?JACJI4KKKKHJKCJJKJK=KKKKK8KIHBKHIKIJFKK;IKK>IKJCKKKHAKKHKKKKHJIJKB@KE7EKKKJJF(KKKJGHKKKGFDJIKJKEKHKK4KJJJJKIKJ>HA@GF8HKFKGKKJ @rCer/175/0_1099_CCS CCAGCTCCCCCTGCCCACCCACGCATACACACATGCCCTCCTGGACAAGGCTAACATCCCACTTAGCCGCACCCTGCACCTGCTGCGTCCCACTCCCTTGGTGGTGGGACATTGCTCTCTGGGCTTTTGGTTTGGGGGCGCTCTCTCTGCTCCTTCACTGTTCCTCTGGCTTCCTGTAGTGGGACCTGGGAGGGTTCCCCTGGCCTTAAAAGGGGCCCAAGCCCATCTCATCCTGGCCCGCCCTACTCCACTGCCCTGGCAGCAGCAGGTGTGGCCAGTGGAGGGGGTGCTGGCCCCAGGATTCCCCCAGCCAAACTGTCTTTGTCATCACATGGGGCCCACACTTTTCATCCTTCCCCACCTTCCCTAGTCCCTGCACTAGGTTGGGCAGCCCCTTTGGCTCCAGGAAGGCAGGAGGGGTGTGTCCTTACTCCGCTTCACTGTGGCCACAGCCCCCTTGCCCTCCGCCTGGATCTGAGTACATGTGGTAGTGATGGAGATGCAGTCGCTTATTGTCCAGGTGAGGCCCACGAGCCCTGTGGCCGTCACCTGAGGTGGGCTGGGGCTGCTCCCTCACCCTACTTTGCTTCCGCCACTCAGCCATTTCCCCCTCCTCAGATGGGGCACCAATAACAAGGAGCTCACCCTGCCCTCTCCCAACCCCCCTCCTGCTCCTCCCTGCCCCCAAGGTTCTGGTTCATTTTTCCTCTGTTCACAAACTACCTCTGGACAGTTGTGTTGTTTTTTGTTCAATGTTCCATTCTTCGACATCCGTCATTGCTGCTGCTACCAGCGCCAAATGTTCATCCTCATTGCCTCCTGTTCTGCCCACGATCCCTCCCCCAAGATACTCTTTGTGGGGAAGAGGGGCTGGGGCATGGCAGGCTGGGTGACCGACTACCCCAGTCCCAGGGAAGGTGGGGCCCTGCCCCTAGGATGCTGCAGCAGAGTGAGCAAGGGGCCCAAATCGACCATAAAGGGTGTAGGGGCCGCCGCCTCCCCCTGTTCTGTTGGGGAGGGGTAGCCGTGATTTGTCCCAGCCTGGGGCTCCCCCTCTGGTTTCCTATTTGCAGTTACTTGAATAAAAAAATATCCTTTC + ?GDFH;>EHEGFH4AEC9HHHDC;BEE?BGB;CCG?JJHCCF@DFI<>;CD=DFCEDB>$@AA;A1B<:D;@B==B-FD?DA?EBDAC5A<-@F<5E?C2G5GG%>AB@EFEFBC9;29&AAB:F6:F>>4BD;A:FDA@5A4@8A,FC@GI9E?ED)F@>9AEFJE?D@9EHDFFD6?D@ED;+/BE@?GEHCDH?EH)CBAC@@HB3B%CGDB:C6EG1JJJJEA>I4EGACG?E;IHDG;?CGDD:8,HGG+DCBDID3FCIC=GBE8G,FE;@7D860A;3A>B(?<@<=:1?@3=0C)A>98>+>B:9DC:D?C4B:1?:E;C??9?8(@60309?>=A9>?:4&C5??DA:C:>B.?-@<59C6GCCA4=91=??6=?7D=&8*9BB<967;:;@@C:F@@?EB:C3?/-A.B?;B<>@?GD>C?7B3?B@<CD?)@?C8?>2:%C;=@@?CB=:@'?:3:0;7??4>89AD5<1::5AC(:A>9:5E@EC8A;,>?;36=A8GF@FE9DA@9?%>A4D5FB==:399=E'AA;@AA>==9745C=7ADBD&C@=??A8@8AC?BI,++@4CHGD.BAA8B-CDCC.GCAFG<@BFG7@AHEI=HADF9BA,AHIFBA8FCBE9>8A?F@HIH@GDH>A>BCE@ABH?GGIAIG:FIF?BI?C>F=IDJIAEBDH=?>IBGG?HC=FA>HDE2E=GD,B95=?BB%GG:2?CII=J>>>B7>>':DF>9II?4E?A6>DJ?6>DEHEACEIEE6DAH;GEFDF>FCDC?G*IIG>DIDJIH6HI;DEIE:HHF/D?BF4IDJC@DJD;BG8DG=BDG=ACBFAC5B=9,=@5CF?CBFFGC-5:AA=I7DC@)ABFFIIAIF4F9'@DFBDC=DA=G5F4JGFE:HGHADBICC=8DGF=0GC8E=H@A+DFD<=EE7@4GD@J???GFCFCGDE=>B=>;CA)DCBCC@A@=2>&D@< @rCer/176/2869_57_CCS ATGGGGGGGAGGCAGCCGTCTGTGCAGCGAGCAGCCGGCGCGGGGAGGCCTCAGTGCACCGGGCGTCACAATAGGCAGGCAGCATGGGGAAGGGGGGTAACCAGGGCGTGGGCAAGTTCTTGAAACCCCTGCTGATTGGTGAGCTGGCCCCAGAAGAGCCTAGCAGGACCACGGCAAGAACTCGAAGATTCATTGAGGAACTTCCGGGCCCGAAAGAAGACGCTGAGGACATGAACTGTTTCAAGACCAACCACGTGTTCTTCCTCCTCCTCCTGGCCCACATCATTGCCTTGGAGAGCATCGCGTGGTTCACCGTCTTTTACTTTGGCAATGGCTGGATTCCTACCCTCATCACGGCCTTTGTCCTTGCTACCTCTCAGAACCAAGCTGGATGGCTGCAACATCGACTATGGCCACCCGTCTGTCTACAGGAAACCCAAGTGGAACCACCTTGGTCCACAAGTTCGTCATTGGCCACTTAAAGGGTGCCTCTGCCAACTGGTGGAATCATCGCCACTTCCAGCACCACGCCAAGCCTAACATCTTCCACAAGGATCCCGATGTGAACATGCTGCATGTGTTTGTCCTGGGCGAATGGCAGCCCATTGAGTACGGCAAGAGAAGCTGAAATACCTACCCTACAATCACCAGCACGAATACTTCTTCCTGATTGGGCCGCCGCTGCTCATCCCATGTATTTCCAGTACCAGATCATCATGACCATGATCGTGCACAAGAACTGGGTGGACCTGGCCTGGGCCATCAGCTACTACATCGGTTCTTCGTCACCTACATCCCTTTCTACGGCATCCTGGGAGCCCTCCTTTTCCTCAACTTCATCAGGTTCCTGGAGAGCCACTGGTTCGTGTGGGTCACACAGATGAATCACATCGTCCATGGAGATTGACCAGGAGGCCTACCGCGACTGGTTCAGTAGCCAGCTGACAGCCACCTGCAACGTGGAGCAGTCCTTCTTTCAACGACTGGTTCAGTGGACCACCATTAACTTCCAGATTGAGCACCCACTCTTCCCCACCATGCCCCGGCACAACTTACACAAGATCGCCCCCGCTGGTGAAGTCTCTATGTGCCAAGCATGGCATTGAATACCAGGAGAAGCCGCTACTGAGGGCCCTGCTGGACATCATCAGGTCCTGAGGAAGTCTGGGAAGCTGTGGCTGGATGCCTACCTTCACAAATGAAGCCACAGCCCCGGACACCGTGGGGAAGGGGCGCAGGTGGGGTGATGGCCAGAGGAATGGTGGGCTTCTGTTCTGAGGGGTGTCTGAGAGGCTGGTGTACGCACCACTCACGTACTCCGTGTTGGATCTTTCTCCCTTTCTCCTCTCCTTTTTCCCTTCACGTCTCCGCATAGCACCCTGCCCTCATGGGGCCTGCCCTCCTTCAGCCGTCAGCCATGACCCTCCAGGGCTCCCAGCCCTTCTTCCAAGGAGCAGAGATTGGTGGCACGGCGGGTGGCTCTGCCTACCTCCACTCTCTGCCCCTAAAGGTGGGAGGAGACCAGCGGTCCCTGGGTCTGGCCTGTGAGCCTCCCCTTGCAGCCTGGTCACTAGGCTCACCCCTGCTTCAGTTCTTCAGATGCTCTTGGGGTTTCTGGGGGCAGGTCCTAGTCGGGCAGGGCCATGACCCTCTGGGTCTGGCTTCACTCTCCCTGACGGCCGCCATTGGTCCACCCTTCGTAGAGAGGCTGCTTTGTTACAAAGCTCGGGTCTCCCTCCCGCAGCCGGGATCAGTACCCCGGGCCTCTCTTAAGATGCCAGGGCCCCGGCCTGCGGGCACAGCCAGCCCAAACCTCAGGCCCTGGAAGAGTCCTCCACCCCATCACTAGAGTGCTCTGACCTGGGCTTTCACGGGCCCCATTCCACCGCCTCCCCAACTGGAGCCTGTGACCTTGGGACCAAAGGGGAGTCCCTTGTCTCTTGTGGCTCAGCAGAGGCAGTGGCCAGGTTCAGGAGGCGCCAGCTGCCTGGAGGCTCAGCCCCACCCGCAGCTTGTCCTCAGGTTGTCCTGAGGTCCAAGATTCTGGGCAATCCGACCTTCTCCAAATGCTCCATTACCAGCTGGGCAGTGCCAGCCAATCCCTGGCCATTTGGCCCCAGGGATGTGGGCCTGCAGGCTGCAGGAGGGCACTGGAGCTGGGAGGTCTCGTTGCAGCCCTCCCCATCTTGGGGCTGCTGTGTGGACGGTGCTGCCTCAGGCACTCTCCTGCTGTACCGCCCTCACTGTGTTTAACCTTTTGCTCCAGGATGCGTTCTGATAGAGTGGGCAGCAGGCCTGGCCTTGTGACAATCTGCCTTTCACCACATGGCCTTGCTCTGTGGCCCTGACTGTCAGGGAGGCCAGGGAGGCAGAGCAGGAGGGAGTGTCAGCAGGAGCTGCCCTGAGGGGCTGGGAGGGGGTTACCTCATGAGGACCAGGGTGGAGCTGAGAAGAGGAGGAGGTGGGGGCTGGAAGTGTTGGTAGCTGAGCGGAGGGGCAAGTGAGAGGGAGGGAGGGAAGTCCTGGGGGATCCTGAGCTGCTGTTGCAGAGTCTAACCCACTAATCAGTTCTTAGATTCAGGAGGGGTGGGCACCAACAACTCAGAATGGGGGCCTTTGGGGAGGCGCCTAGTTCTCCCAGCTCTAACCAGCCAGGAGGGACCTGCATCTAAGCGTCTGGGTTGCCATGGCAATGGCATGCCCCCAGCTACTGTGTGCCCCGACCCCCGCAGAGGCAGAATGAACCCACAGGGAGCTGATTGTAATGTTTATCATGTTGCTTCCCCACCCCTAAATTTTTTTGAAATAAAAT + *++,++'*#*,+++&+&+(**&),,(,,(+(++$*'+*,)+,-+**-)-,+++('*(*)(++(,*'(,*.+-,.,-,,**'((&&--+')+,*(()$+,,((*,,'(&$*,%(**)-+(-(,,)%'*%%+'+$(,,-)',--)*,.+-..,,++(+++-*+,+$,-((--*#*%%)&(()++(,.--,("#$,+(%+''%(-%(',,(,'#*('$%,'*''$+-,*-*,)++,+'#),*+&-.**-..,)+(.+%$)-,.200,.1*/2.00112,.2-01../12--/*/)1.--&--+/(***++&)(+,.0,+./-0')//.%/*02*00,//0*/2,/,0(-)(0.'0+$+0*/)//+//0+2/,-)#''$&(%+0*-2-.+'0.2,%+*&.(/11*-,#,.1/0*1/.0-.).--11/010(.11012-)*+%0)+&*)./1+/.-0/+',-++,/-./,,*+'+0,2.*(,(/,2,,,((*)/*/,*/0-0,/*,'',+--.-),-0-/-*''2/*++''''*/0/0&'00/.')%+*-.2-,)1..+./)1.11--011-./*-.-'.0111010#0-0-121+1,+%*-+++---+0-+%%/1.*-).--*&,1,/+*,2/01,0-/0/0*.*/2.0,/1(*-.'(1//,*'0,,2-.100+''2/..+(10.11./--+)*+&')*&*+-'))*,),+),+--*$&,-,',.*'()(&,)$,+$)&(+-,((,-))-)'*',.+.+---(.*())---*),-+(%##+*,,-*,-)+*(-'),&&,,-',+%&,-*-,*-)+')*(%))))&&+%,)+&(&)**',-(())(+-'+(+*,**('+(-*--*-*,(+)(,'*,$,,,**(#(,()*'----+)(+)($)+&&&%)-(',-),-)*-+,&+'-+)(+*()(&+&*&%*-,+',,*)-,-(,'*$*'-,()&,+)**,)*&(%(#""%'('*(%&'(+'-)*&*)%&'$$&#%&&$-+,&,-(-,)+((&&)))&%""""$'(&(+*&))'+'++*+((&'()'&(+%$'$%$%%&&%&%'(*#+(,,,+++%()+-*,(,),+*%)&+('(+'+))&)-**(,',-*-,+),-)**()*'&(*+'',,)+--.+--,,*(,+()%((#+--.**),--*)-*.-------&+).+)++)()-.),-+,+,,&,--)*-,*--,*-.+.,(,+,,-*(,-),,)+-(,+*,.,(*',)-,(),(,,),'-(,'+.,).,+,.-,(*''$)'(''*$(*(')-),,*$%(('()$,-,',,*)*+)-+&*,-,,*-(,(*(*-*,*+*()+)$)+&+)+',,,+(,+--$+,*,((*(,-,)+$**+(')++,''%,-.,-*,)---),-)$,.,-*),--*+,(,,)-+.-+(,+-.*(,'(-)'#%)-',,--#*+),+**-+.-+,()&((,+(.+*%$$+),(+-+),.+,,+'#)&+,.$&-+)+(*,-*)-,&'&(,$-++,,&&&',,*.,-+()&+-+(*,+&+)(+++%))&$,-,)'+-*(*')$&&*,-,%#$$$'+,')(+*+*,&)(,-*,-).+-.+--,,),-),,+,*'&*-)+(&%),'--.,,+(*)#+-++(++*(%*$&-*'(,&,+,..-+,,,)+.++))-,*,.,,)+*,(+(,(%',,-(,,()(&#-$,,'(,-+((%#*)*--),.,,+()%+-,,--(*,,-,(++,',-()*&(*&&'*))%$+'+)++(+*,)$&,*.*+-)&-,++,%),*#'&&#+-*,+&+--**)),,,.-..,+''(&'$')(,+(-+,,++,+(-(+,++(,--,--,--,)+--*,-**#))-*,**$+)++-(+*-(,,)*(*,,,-))*,-&)+-,*))**%,,--,*(*',-()-*+,&--,('%),+(-('+)%'))--.-+)*-*--)+*,+,+-*,.,,-*-'(,(((-,,-.--,''$,,-.+-,))('&'*-,)$')%%&(+*.+,)-,,,*.-*+)),(')'))+-(-(+(--+).#'*&%+,-)$*$,,-,-(.-)-,'&)&+-*),)+$*)(+(*'*(+.,,-.,,)-*--'-&-+-,+'+'-)'%*+,$'+,'*,#,)'+--.,,'',-)(,..+($()-*(+,(&$#+)%,)%,,*--,---+&()+(##(+,*+--(,+(*---+-.,+,.*+-+),-(+-++%))&()'+&*,$,,,)%"'),%+---,-),)+(-)-+++'')*&*)+,,*&+,--*,-,(,+&)&,-.,*$$**-&+)*+$#"**'((+,-,-+),+)..++(,,--,')%,+.($(*)(,+*,.*,*+*+*+--*-,+%,%'(+..,'-,*'+*,(*('+.,+,-*((-,--,()*#++,--*-&*-)&)(&''#+----*-)*-*)*-----(+.,)-.*++)+-,,*-&+',+---*++,-+*-,,+,)-'''++,*%-(',()-*-,,*$%%,+%,.,+--#)+--'**)%),*(*&&*(%'))),$,-(,--(,--,$%)*'&,,(++--+,())$*+(-,,)&',),-'(,((),+)$&'&+$(,.+)(-+*&,.,)((,-.,(,++*&+',)+)))&(-&(',)%+-,)&+(($+)+*--+$'(-,-(--*%"+$,-*--)-*(),---,)*')+',+-.+)-.,*()')(+&'*,+()&-,**#++(,--,+,,%*,,,++$*)+)+,*-,(+(+,-'*+#',---)+,-+',.--,-)-+*--+$+--,+&,,(,---*-+-.++++&(+,,,,%,-+&%),+$* @rCer/178/1293_57_CCS CCAAGGCTCAGGCCGCTGTAGATAACACCACCTGCCATTGCCCCAGAACCGGGACAAAGAGCACGGTCGCTCAGAGAGGCCCAGGTACCAGTGCACCAGAGAAAGCAGGACCAAGCCTGGGGCCCCTGCCTCCCTTGGCCATCAAGATGATGTGGAACATCTCGCAGGTTCCTCAGCGAAGCTATCTGAACACAATGAGCCAGGAGCTGTCCCAGCGAGCCGAGTGGCTGGCCGGGAGTATGGAGCAGTCACTTACAGAAAATCCAGAGAGGTCCCAAGCAACTAGCCCTCACCCAACATCATCCGGGTTCTCCGCGCTTTCACCTCTTCCGTGCCGCTGCTACCCGGGCGCTGGTTGACTACCCTGATGTGCTGCCCCAGCCTCACCCTGAAGGCCTGGGCCACGGCCGGACGCTGTTCCTCGTTAGAAGAACTATCCTGTACCCTGCGCCAGTACCTTCGCGCGAACACACCCAGCCCCGCCTCGCCACCATGATGATGCTGCAGCGCTGGAAGGTGTGGACCATCTGGTTAACAGGCATCGCGCACAGAGACCTGAAATCCGACAACATCCTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCTGGCTGATGAGGATCGGCTGCAGTTGCCCTTCAGCAGCTGGTATGTGGATCGGGGCGGAAACGGCTGCCTGATGGCCCAGAGGTGTCCACGGCCGTCCTGGCCCCAGGGCAGTGATGACACAGCAGGCTGCGGCTGGGCAGTGGGAGCCATCGCCTATGAATCTTCGGGCTTGGTCAATCCCTTCTACACGCCAGGGCAGGCCCACCTTGAGAGCCGCAGCTACCAGGAGGCTCAGCTACCTGCACTGCCCGAGTCGGTGCCTCAGACGTGAGACAGCTGGTGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCGAGTAGCTGCAAATGTGCTTCATCTAAGCTCTGGGTGAACAGATTAGCCCTGAAGAATCTGAAGTTAGATAGATGGTTGCGGCTCTCCAACAATCGGCTGCCACTTTGTTGGCCAACAGGCTCACAGAGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTTCTCTGCTCATGGAGGCAGCCCTGTGATGTCCTTGCATGCAGCTGGTGAGTACTAAAAGAACTTGGCATC + *''$&#&($#%$)%('$######&"#%)($(%''&$"$$#$"##$&(&$$%"""$%#&(%%&&%&$#%#'$$%$'$*,++*$%'&%'-,+-**%((%#%&&*''&,++(,-*,&%#""*,,%%,-()*&$#)-)+&,&-')+'-*'++)+#'')*+%%&&%''&*)&$-*)('#(,,,)(+&%))+$)()*+,*)')&',((*&+'()#%,,('+((((+('&(,,&$#+++&++#)%&',-,('/1,0/*+.+/,-,/0/*--+'.10,/(/..%1(,,-&-(*(12((,-'-$(&,'+'-+-(-1,0+/02.10.000).+,&%',&-.0*01*110-..+-*&21)#"%*/*1+,/-,*+,&.+-&+)$/,/.-,&$$%&$#-//+'*0*0.1.451)/./5606-/+.2-+351%1,)/.+)$(2,21*21,*2''+'+04,52,46433232'.'.,-%.0.(-*/1142/131/%%+)*)1,*-/(*.-00311+-(/3-1),/+53)(,(1+-242602,(35.,#**403$)44,1&+')()221+0&&10,+-6,/./1+/041+#&+./*4250).1-%*3,*60-0./0.(+3-.(0*.3.+0%..1'-,4%0+.332,)#'-'//,++,%$"$-/5.$..3/442551.+*0%3525/-3-/.-310*011656151/1/).,'3513/%.*40../%(433()-/5+,/)$4$2+6/041666354210/-+3*#**&*-+,,%)-/.%!!#(1-5/400,01(4/5,4)*1//.-(31'+/2.100)140(#)450466,/,1022/%12.31/-,#+&),&+.)1+,*%,)//2/+0)+-0,23146//(241/*161642((&./.$-/0.-/'*13,(#,/3-(,.5340*0+--$--262+,01112)+)0%54,0(+'+'+110+-&+/.&,00+,+''/0)&0,+,0,-&+//,,+%(,11---.&%,*..%)*0,11(&&$*0/.',&%'-1-,-'+''+.),-./)&&(--1*&%('+'**0-/%/20100'.-02.+-//&25/4'1'*$1,5*$+.452522214)33%40526.21-.0112'324/41-+5/566/+5.2..0'2/42*+.&)&&**'.0/,*&(+)/0'0,-22-)/+-+110-11111+,))1*++)).%01111.10/+1/,+),/---+'.+,,$"#*/*%'%#%'$/1+0)&'$- @rCer/180/0_1232_CCS GGAGAGTATTGAGCCAAAACGTGCTGTAGCAAGAGGGATCTGGAAAACCAGGGCTATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGAACATCACCTTAGAGATTACTTTGAGGATATGGAAAATTGATACCATTGAGATAATACTGATAGACGTCTGGAAAGAAAGAGGCTTTGGCTTTGTTACTTTGATGACCATGATCTGTGATAAAATCGTATTGCAGAAATACCATACATCAATGGTCATAATGCAGAAGTAAGAAGGCTTTGTCTAGACAAAATGCAGAAGTTCAGAGTTCTAGGAGTGGAAGAGGAGGCAATTCGGCTTCGGGGATTCGCGGGTGGCGGTGGAAATTCGGACCAGACAGGAAGTAACTTCAGAGAGGATCTGATGATATGCAGTGGACGTGGATTGGGATGGCTATAATGGGTATGGAGAGGGCTGAGGTGGCAATTTTGAGGTAGCCCGGTTATGGAGGAGGAGAGGAGATATGTGGTGAGGACTGGATATGGCAACCAGGGTGGGGCTACGGAGGTGGTTATGACAACTATGAGGAGGAATTATGGAAGTGGAAATTACAATGATTTTGAATTATAACCAGCAACCTTCTAACTATGGTCCATGAGAGTGAAACTTTGTGGTAGCAGGAACATGGGGACCATATGGTGGAGAAACTATGGTCCAGGAGGCAGTGGAGAAGTGGGGGTTATGTGGAGAGCCGATACTGAGCTTCTTCCTATTGCCATGGGCTTCACTGTATAAATAGAGAGGATGAGAGCCCAGAGTAACAGAACAGCTTCAGTTATCGAAATAACAATGTTAAGGAAACTCTTATCTCAGTCATGCATAAATATGCAGTGATATGGCAGAAGACACCAAGCAGATGCAGAGAGCCATTTGTGAATGGATTGGATTATTTAATAACATTACTTACTGTGGAGGAAGGATTGTAAAAAAAAATGCCTTTGAGACAGTTCTTAGCTTTTAATTGTTGTTTCTTCTAGTGGTCTTTGTAGAGTGTAGAAGCATTCCTTCTTTGATAATGTTAAATTGTAAGTTTCAGTGACATGTGAAACTTTTTTAAGATTTTCTCAAGTTTGAAAAGCTATTAGCCAGATCATGTGTATAAGACATAACGTTTTTCCTTTAAAAATTTAAGTGCGTGTGTAGAGTTAGAAGCTGTTGTACATTTATGATTAATAAAATATTCTAAG + S'-*-2*-$5*45-0*383035-56.487.+0.1&#$''*)26%72.&31(57,-+8333:98726&84+9+4)0'75312-337:&31:,538.95,51-55,%1)733664.504610&7)1/6,74530+&(.-3:):40/9535--9429406*)16-*4<556/0/0$5*6,34<7'&251227:/>?7?:4??65?96%8<65/-3'401073)426$/1/;?>44985/667/1'656,%0+30)2/4)203;28:-;;::/1;7:84165/:1>;/9,46408529%3&;799+,4:15>>>;21698272>72=/:9978075(0-35$3927*)6.):=5289879./94&64&93-9->+$<56=4092$8(21:66=55?'.=6973$)39995'68/$140+%573.*1-2:;;:2)7-9>72.;7503.60+==;80(01%%,8.$1)6)8,)==*:)=9*%/&.55/'8;*9.;240>8%-+%))+739(00382%2)0,-4,36$33:9469/>.-88>:/+7.<9)44./<778,66+%&6,672,5(9))-)9'4)5698=244+094++&22'595*&(156'3)(.,52)+13%3+:242&0,3*,.23,3/941:5'-5320-++6/)0-496+380,16:4%+0(4%300+'+&)'/-8$$''%/-,2-5743/5-:31:+/,2&63*643-663280-06985/)486+&/.-%(53.4---%34616*.6;54639435.&431'+:689.-914.30.235*.'7,-/::,2-*752(/36-4*&4/613.9426..4/37645&0+744/25483),1+'+/5230,313/68/+57,71)37.5135:3747/+.)'-5372-4-2&77'262-,69&76&5,:,0/,0.1&7556796438172::88655-&%3+1;9/5'72/+4-33.34/772%3',,1-0851&333*$%-,,/2&/154,546)4060+04(4*-0-1,2/63&0(-)3//641+*/25352+3+)4)%(.1012044.$2,.342$2*$230&/22/.),1235,5.-)/)..)%%'&.)-/5521/44/'4433-0,2+#21/2/55&0050(*555465550/2)()..*,1,4&/0+(%2+%*).#0)4)/264-$%/2,#/0 @rCer/181/21_1807_CCS GTCTGGTCCGGCGGTAAGATGGCGGCTGCCGCGGAGTGCGATGTGGTAATGGCGGCGACCGAGCCAGAGCTGCTCGACGACGAAGAGGCGAAGAGGGAAGCAGAGACTTTCAAGGAACAAGGAAATGCATACTATGCCAAGAAAGATTACAATGAAGCTTATAATTATTATACAAAAGCCATAGATATGTGTCCTAAAATGCTAGCTATTATGGTAATCGAGCAGCCACCTTGATGATGCTTGGAAGGTTCCGGGAAGCTCTCGGAGATGCACAACAGTCAGTGAGGTTGGATGACAGTTTTGTCCGGGGACATCTACGAGAGGGCAAGTGCCATCTCTCTCTAGGAAATGCCATGGCAGCATGTCGCAGCTTCCAGAGAGCCCTAGAACTGGATCATAAAAATGCTCAGGCACAACAAGAGTTCAAGAATGCTAATGCAGTCATGGAATATGAGAAAATAGCAGAAACAGATTTTGAGAAGCGAGATTTCGGAAGGTTGTTTTCTGCATGGACCGTGCCCTAGAATTTGCCCCTGCCTGCCATCGCTTCAAAATCCTCAAGGCAGAATGTTTAGCAATGCTGGGTCGTTATCCAGAAGCACAGTCTGTGGCTAGTGACATTCTACGAATGGATTCTACCAATGCAGATGCTCTATATGTACGAGGTCTTTGCCTTTATTATGAAGATGTATTGAGAAGGCAGTTCAGTTTTTCGTACAGGCTCTCAGGATGGCTCCTGACCATGAGAAAGCCTGCATTGCCTGCAGAAATGCCAAAGCACTCAAAGCAAAGAAAGAAGATGGGAATAAAGCATTTAAGGAAGGAAATTACAAACTAGCATATGAACTGTACACAGAAGCCCTGGGGATAGACCCCAACAATATAAAAACAAATGCTAAACTCTACTGTAATCGGGGTACGGTTAATTCCAAGCTTAGGAAACTAGATGATGCAATAGAAGACTGCACAAATGCAGTGAAGCTTGATGACACTTACATAAAAGCCTACTTGAGAAGAGCCCAGTGTTACATGGACACAGAACAGTATGAAGAAGCAGTACGAGACTATGAAAAAGTGTATCAGACGGAGAAAACAAAAGAACACAAACAGCTCCTAAAAATGCACAGCTGGAACTGAAGAAGAGTAAGAGGAAAGATTACTACAAGATTCTGGGAGTGGACAAGAATGCCTCTGAGGACGAGATCAAGAAGCTTATCGGAACGGGCCTTGATGCACCATCCAGATCGGCATAGTGGAGCCAGTGCTGAGGTTCAGAAGGAGGAGGAGAAGAAGTTCAAGGAAGTTGGAGAGGCCTTTACTATCCTCTCTGATCCCAAGAAAAAGACTCGCTATGACAGTGGACAGGACCTAGATGAGGAGGGCATGAATATGGGTGATTTTGATCCAAACAATATCTTCAAGGCTTTCTTCGGCGGTCCTGGAGGCTTCAGCTTTGAAGCATCTGGTCCAGGGAGTTTCTTTTTCATTTGGCTAATGAAGGGCAACCACCCAGAACCCAGAAATGCAGATTCACTCAGTTTAATCTTGAATGTGGAAACAGTTCACCTCCTCCCTTCATCACGTCTCCATGTACTTAGAGCAGTTTCGTTTTCTCAGTTGGATGCCCTGTGTCTCTGTGAGTGGGGTGGAGCAAAGGGAACCAATGCCGAAGACCGCGGGCAGGGGAGGGAGGCGGGGGTGGACAGGGAGGCAGCTTGTGAATTTTTGTTTTACTGTTTAACTTTATTAAAAAAGAAAAAAAAAAGAAGAGAATAAATGTTTTGAC + 6,&88;5+73553:;5>4<50?5/1:=BC=?F:5==AG>:DA6AB=B:EB>;0HG=C?IFHG:FFHIEGII&C@:;HFGGJD?9ID9B>DFGG=B?8AEF2G,=0>9-?7<839=%5==B:F3=D9AGG7/',@EA5FGDEHD@HD==?CDF@$IGB;>DFHHGG>68C5@IE,?FGI;JKKK;KKJ@KK3KKIKKJ:KJKKJG=-DK;9HFKCJ:KKDIKJCKKKKKJKK?KKJKKJJJDIJKJJGKKH1HGG>DKKJKJC0KKIJJIEGKGJJ=F>KKHDHK>FAJ@D>KJHKIDE,EI'>?BBIHKB5FFKJIKIKJCBCKKHJG-GGGJIFI8CEFIHIH8B3;43EG?2KFH?.FF@I2IKG;KHJ2K;$JJKJJJJEGKKKK4KBK?KKCKKCKE%IH+GGG/;*HDDE=K:G?,B=I>G'FBC7KKC;F@JEJBFH@KGJJIKKKE>@IKKKHKJJKAKH%FDIGJKHI:=/KF7KK:JKKKKHGKK=K>BGK?=E@I@AH?DJAI@HH7GD*A>C86HHJFGJIJDFFIJGIDKIGF9JB=G>CK5H6=F/JGFBDI>IJKI@@KCE6JJ3IH7DJHGGFFJB8H?HK1CG?G@AH7BJAKDJ8E7JEJJ=JKIFJJ?G=IHKEF;0JC0/4<>HDBCJIGAD=*KIFHCKKI.JJK@:.:9>=80><8=/==?>?840+.65;:;>5248@9:4?===?6=88;98-4312:$;3=<>8;3;86<9<202,*/690?;7653042':BA@<7@<>3=:4:.<==996>B<6/;82/3592:5.'+<913643?;>?69A88??>;8@:85?CA??::<<=4B<69;55.,/96=.95?4@8@;?.>&?:8%7;96>:<3246::);7252-:;<4?@;5,.;1@97;3=A:3BBA><218:9'64-7<><<:9210.+4;6;859>41+$>A@9:1;<::9,=4=AA=A4=::57<=BA>;8-;AAA<6:8@62>$;3>5493$;9@8@B2:A7@@:>=:5;>694>9?6;:<2:9C7=C-A;0A<;=A@>;<6836@:<>/=B5;88;<7:+??;17,180;8@9@9@;;73..5877=@=99399@?1@@=9.5B718:8,/:7056=/B@?>A8@;3-4;A?=B9>0;5A;A=:A6:5;:=9;<=;:B<;<:;A;8964BAB@6579<@B;B>?6<4>CC==B=<@15348:=>:AA4==;6:<63::23?=5?:-A=<=?4=@6<<1?9>/@;A:;C??:A6>=?>@@@6@>5;B5??,B7BA3@?===@@>6>7>9;969/:A5;>=6;1:>98'<4?<;A9B98?>7279:??7B<<=52==4>BB@782;:5<>4*:;;;/:@7:@65.<<@664<<=9C8599>:B?;;:BC>=>6<@==;7?471-:<77=1:==8BC;7=?;9<:<56=?<8:7;-9=1:<9;0:<)<;;? @rCer/183/1555_56_CCS ATGGAGTACAGGGTCGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAGCTGATCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCTCTAGCTAGCTTAAAAAAGCCATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATCGTGGCTCATTGGTGGGCAGTATTACTTATGGAATTGCTCTGATCATGCTAATGCTGGATTATTAAGATATGCATGTTCACACTCCAGTAGTAATCCAAAGTTGCCTCTCCTAAACCACTTCAGGCCTTTAAAGAGGAGGAGACTCCACAGCCATTCAGCAACCCCAGCGTCAGCGGCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCTTGGTTCTCCTAGTGCTACAATGGGAAATTCACTCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAGAAAAAGTGCAAGAGATCATGTCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCTGAAAATTCCAATTTGGGGGTGGGAGGTGAAAAGGAACCCATTTTCTTATGAACAGATATTTTAACTTAATGGCACAAAGTCTTAGAATTATTATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTCCACTTGCAGGCAACTTGGCTCTCAATAAACTTTTACACAAATTGAATACATATATTTTTTTCAACTGCCAATCAGGCTAGGAGCTCGACACTCAACATTGAGACATCATTGCAATGTACTACCTTGTTATATGCAGAATGTATTTCTTATGTACACTGTACTTCTGTGTGCATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGTCTTAATGAAAATTACTGTTTAATTGACATACTCAGATAAAGAGAATGGTGGTATTCAGTGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAATGAAAATCAATTTACCTTTTTCTTATGATGAGTTGGTTTGATACTCATTTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTATGCTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCATATACTACTTCAAAGTTCATGATGTAGATGTCTGGTTCTGCTTACGTCTTTAAACTTTCTAATTCAATTCCATTTTCAATTGATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCATGAAATGATTCTTTTATTTGTAGCTACTTATTTGTGTTTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGCTGTGTCTTGGCCGGCGCGGTAGCTCAAGCCTGTAATCCAGCACTTTGGGAGGCTGAGAGGCGATCCGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCGTCTCT 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><=-1/678636&0$'19?>>;81740(=&=74?:6*'553;96?<85468827-:<:50%0)&/62)8:1=:9>9;?;;32512&:4<>:983=5;762)2.7:.,%;79;63:4638721-6:1746950,118:37<1+366=>==:-:=144331%7=71$320<81)9>56794):9:+4:9<;89;;985:%>.99=>>=33::9*35;71840&1450<)>6;59==96252:3+672;47*379-65$7:;;=40./758%.7=98:47959*)376>:3(5<09=454,(20/#&6-927-8(87:3$/6(%':?5??75-6.76'0.-'77.9303=);;5-99><986:)/89875<>96/:<&278'18238;4;=>6<99-2515/-5<0974/7;5487;<3788:(7%+,9/70-$#%3+'+2-7)59+545#3,"&).446./8&89355%9-99934-2(021555,)959429487%13$27364)-07.5664325&.233,&6428435006/05284:5544057',*&84'636(-(;6::1587(25.1%+-574':7:1;864(9783.2:208*..%$.-&4.4(00%*(28*77+7.6:5551.*3625,5636-7547+58422*3585-83)($(22(94513227'340;414'0/;3853:9:356:6439:6.275'49:6:648(/3&-:5;9:70796)/1.%5:69/53101112.**&-32+434557/./0%34+*3-1*20+&%013,23./&1,63,&##242,'56-(111.*44(1-('))33.*".(223213*7748,,-.$)/43625&610514.3/6*1/+/&4252(2.414%+,7733.356:6'4-57<1864:75/)9:2597*-4/732.747*13(,)/-$0073-&76761$+1231,01(3(4'7.107:/060%.:6%&,776+10%673948.7540587',:333(45605.65.32-343232*9:7322&34'02783-05:248472%4467&'/&15865%234-2$64%3,773378888856%749..3407402,159596546+2*)+*/558196::9/'93.3.80:662,9/454920331670367/82041-+-./,.2483216915::/460-40023//583750.2-&7%357:994.80035$06055:7:63(:26:2;5:/2657$8:/;805501(4667+,33%,1/81)2279+/46/310&6254375#7':8-60)12/684'214+3-0+'-0-6.951&.3)761#+/6868364693)3349657091'+5998-55973-.25524.53-*4848-97986798900(5-1#+3*1&,45589:/46/63*2,36*3097%65)6--.3,150*/&.'/$$/#(1-//55,60+5-//*50//,**)'-./-2302645-0044-3/'0&3540 @rCer/184/1927_63_CCS ATGGGGAACATTGTATCAGACCTGCTACCTATACTATGGTCTACCTCTCCTCCAGTGGAATTACAAAGGCACTAGCTGAAATGCCTTCTAGAAACAGAGAAAATGAAAACTACTTACCTACTTTTGATAGCACGGATTATTTATAAAACAGATTGAAGTAACCCATTAACTGGCAAAAAGAGAATGAGATCGGATTTAAATGTATGGCAGTAAGTCCTATTGATCCCTCCAGTTATCTCAGTATGACTGCAGTATATTCATTCACTAAAACCACTCATTAGATACCAACTACACACCTGGCACTGCAGATGTAAAGGTCAGTCACACATGTTCTGACTTTACAGAGTTCACAAGTAGCAGTGGAGGAAGATATATGTGGAAACAAAAAAGGCATCGATTCTATTCAGAGCACTGTTATGGCACAATGGAGAGAGGGGTCTTTCTACCTGAGAAGATGAGGAATAGGGTCATCGTAGAAGTGACTTTAAGTCTTAAAATTAAGAAGGGGATTCCAAGCTGCTTCAGGCAGAGACACACCGAGCTAAAACACAGAGGTATGAAATAGCATGGGGACTTTAGGAACTGCACAGTTCATTCTAACAGGAACAAAAGGCTCAAGGGTCAAGAAATGAGGCTGTATGGAAAGAGGTTCAATGTAAGTACTTTATAAAATAGATTAATTTCTGATTCAATGAAGCATCTCTTGATCATTGTGTACAAGGCACTAAATTCATCATGGAAAATTCATTAGGATGCATTGCCAGCACTTTGCAGACCTGATGTTATTCAGCCTCAAGCTTTCCAGTGGCCAAAGGAAAATGCTGACTGCTTTTCACATATTTGAGTCAAAGATTTTTTTATATGGTCAACGAAGACTAATACAAGGGCAGTGGGATTTTCACAGAAGCATGCCATGTTGTTGAGAGCCTCTTAGATCTTCTCAACTGTGAGAGAGAAAACTGAAAAATTTTGAAGACACTGAGTCTGGAGAGGGGATACCAATCACTGTCCAGTCAGGCGTTGGTGGGAATGGGGAAATGGCACAGGAATGCAAGCCTCTCCACCCTACCCCCAAAACTCCAGCCATACACTCATCATTTCACAAAATATAAATGAGTTAGCATTAAACATTTCAGAGTAAATAATTCCTTTTCCCGAAATGCATGAAGATAGAGTAACAGTCTTCTCACACTGTATTTTTAGGGTATGGAAAATTTAGAAGGTTAAAGAATTACTGCTTCAATTTTTCAGTTAAAAAAAATCAGGAAGCTCTGTTCATTCAGGCTATGCACCATGTGCACAGTCAAGAATTAGCAGAAAACCTCTGCATTACAAACACTTTGTGCTATAAAAAGTAATTTTTAAAAAGCCACTTGTGTGTGTGTGTATATATATATATATTTAAAGCCAAGGTTTTGATACTTTTTTACAAGAACTGCAAGAGAAAACAGATACCTGTCCAAACCATATACTTTTAAAATAGCATTTTTTTTCCATACAAGCTGTTGTTAATTTGGGGGTAAAATGCTGGTTTGCAAACTTCATCAAATTGTTCCCAAGTGGATTTTCCTTGTTTGTCTTCCCCCACCAACCCTCAAGTTACCATATTCGATGTAAGAATCAGGCATGTTAGAATGTTGTGTCACACTAACCAGTTCTGCTCTTTTTGTCTTTTCATTCAAGTTCCATTAGCTTCTGTGCGCGGTGCCCTTTGCAGTCTGGTGTCTCTTCCAGAGGCAAGGGGCTGAAGATGGCGTGCTGCATCTCACTAGCTGTACTAACATAATCTTGGTAAACTGAAAACCAAATGTGGACATTTGTAAAGTCAGTGCACTGTTTCTAGAGAGAGATTAAATTCATTTTT + 6=:?>9A25AB@DGEECD:4;89495D8CFCE5<6@)9DEE3;1CBEFFA;8EFF8CFD8G6>DA9@?*;<>?@@EE7>?CDD6B/A?DDCG5@DBFDAAEFG=FCEE?C=@C,@F??<:>C9EDDCE)B7DB3;D=C>DFD6B@?*=C1?:>>:>9ADFB=+=@B><;E>ADA6@;@@:?*=:0=?FDB<1=16@EAD;:BEC?DCGFBABD@>==91@C=A779??B>?=>;;;FD>6=?FDGBDCEBBFCGA=8<92@DB@CA>BGAE:&G?<:>:A>FEECBE<,8@CDCA(>9F<:>B9E;AACG=BB>?FEEDEC@:BC>>B99C9AE?B=B8AA>;%B?B>6::CG=B??BD3DCFFC<0?9B<;C7@DEBA?<6FED?CD=?CE=D:C86C>=BA+A:CCCC:8==$>F:=9C@?8.4783;:;48<=B:=9=>:>165;>&AAB@59A>9AB>C=B=@?:?@1?B?1C<=<;@6C?3?=<1:?5=A@8CCC<<7:>;B;>?CAC>@??@><=>?<=;6>/9=AA?=7?8A>@ABB=>>A993<;;75A?96&8=?<37-;5A6<@8:A;;:.'9.1.9(8:02,99=>+>:0:@>8;<@0B@?>>@9;24:A>:9<8;8@A.<>?2<;BC5A6@B;C7C9B?7A7?CC8;@<?@@>=8)7<<4=*>:B=:79/=@60:159@<4>A=7=>637:+<@@;<@6<7@9:B:;=A8<:;;0=CA;==;=AB??=;3?==99=:(:9?,AA498??399/5;;;:6;73?B710<=C8A:CBC?=B84?>6>@AAA)C>7BB<1;@18>6>:>>>?>;>6=?4<@<=>94/>=4/55;<@<(=AA(=9==B>?(>7;>9332;>B<<>7><4.=@CA;>@>758/;=8===2@BA=;73ACC6;@0A>B=A?96=??=:<19A=.<<6<=:<:@@:09>B3@A6A5?==2A@/9BB:A6?9C?7B?9@:=A?A>2>:;3?>?8)>2?<299:@??@+??8>?8>438BAA=>?C:><5;66>?.@>=;8=@@/>;BB<C@=:>5>93@@?6BC=>;@?1;7=0558933919)//12,0422109('5906B?=@A6A>@3A:>4<4@AA=>@AA2<9:3@:;?:>9B<84258;%AB==B>>6=A:?/:@:98<>;@=>=?B28>='@=BC>AAA:=>>(5347BCC;8BB?C?C??CA<>5?BB?-7705&36<=>=CC=>@??BAA9@C::@=,<=?>6AB3>99;;89??<2=4=;@=@>==?@6A?6<::=9=7..%53*$*+-430'9).3FEAFDA7:7>@@;<>3<;:>;G6;C8DBBFFA=>;>>5BDGG8>C*BFEE:=8;F8=8AC9>>A7B?1CC0AB@DE;@>CF@4@>CEA@BB?=BCFA9D?D>1?8?A@?=>FB8@2DGDFDGCDBD:) @rCer/185/1600_55_CCS ATGGGGGGGCAACTCTTTTGAATGGAATCGGGCTGATTCATCGCCGGTTCGCAGAGTCAGAACCGCGTCGGGTCTGCGCCGCTGCTGCTGTTGTCTCTGTCTTCACGTCACCGCAGAGGCAAGACAAGGGTCCAGATCGCGGCATCCAGCTCCCGCCCGCCTTCAGGAGAGAAAGAAAAAATAAAATATACTTGGGGAAATTGTGCCTGCCAGAATTAGCAAGAGCTTTCTTTAAGAAGAAATTTGTCAAACTCAACAAATTGAAGGTTAACACCTTAAGAGTTATAGTTATTGACCAGAAATATGGACAGACTTCTTAGACTTGGAGGAGGTATGCCTGGACTAGGCCAGGGGCCACCTACAGATGCTCCTGCAGTGGACACAGCAGAACAAGTCTATATCTCTTCCCTGGCACTGTTAAAAATGTTAAAACATGGCCGTGCTGGAGTTCCAATGGAAGTTATGGGTTTGATGCTTGGAGAATTTGTTGATGATATACCGTCAGAGTGATTGATGTGTTTGCTATGCCACAGTCAGGAACAGGTGTAAGTGTGGAGGCAGTTGATCCAGTGTTCCAAGCTAAAATGTTGGATATGTTGAAGCAGACAGGAAGGCCGGAGATGGTTGTTGGTTGGTATCACAGTCACCCTGGCTTTGGTTGTTGGCTTTCTGGTGTGGATATCAACACTCAGCAGAGCTTTGAAGCCTTGTCGGAGAGAGCTGTGGCAGTGGTTGTGGATCCCATTCAGAGTGTAAAAGGAAAGGTTGTTATTGATGCCTTCAGATTGATCAATGCTAATATGATGGTCTTAGGACATGAACCAAGACAAACAACTTCAAATCTGGGTCACTTAAACAAGCCATCTATCCAGGCATTAATTCATGGACTAAACAGACATTATTACTCCATTACTATTAACTATCGGAAAAATGAACTGGAACAGAAGATGTTGCTAAATTTGCATAAGAAGAGTTGGATGGAAGGTTTGACACTTCAGGACTACAGTGAACACTGTAAACACAATGAATCAGTGGTAAAGAGATGTTAGAATTAGCCAAGAATTACAATAAGGCTGTAGAAGAAGAAGATAAGATGACACCTGAACAGCTGGCAATAAGAATGTTGGCAAGCAGGACCCCAAACGTCATTTGGAGGAACATGTGGATGTACTTATGACCTCAAATATTGTCCAGTGTTTAGCAGCTATGTTGGATACTGTTGTATTTAAATAAAGCAACGAAAAACGCTATTGATGATGCTTTCAGTGTATATTCCTCTGTTGTTCCTAATGCTCAAAATCAAGGGACCTCTGAAGGTGTACTTGGCTAAATGTAAGACATCTGGCATCATCTGCAGCACCGTAACACCTTCAGTCTCAGTTGTGCAATTACTTCTGTTTCTTTAGTCAGGGTCTTTGCAGATTCTAAAGTTATACATGAGTACATCAAAGTGGACAAATTTTGTTAAGATCCCATTTAATATTTGAAAAATCAGTAGCACAAATATATTTTGATTGTTACTTACAAAATAAAATACATTTACAG + KKKKKKKK5KKHKKKKKKKKKFKKKKKJKKK7KKIDKGJKIIKKKKKKKKKKKKKKKKKKKIKKKJKKKKKJKKKKKKKKKKKKKJIKKJK>KKKKKKKJJKEKKKIKKKKHKKKKJKKKK=JKKKKKKJKKKKKKKKKKKKKJFKKKKIKKKBKKK:KKKKKJKKKJJKKJK*KKKKKK2KKKK?KKJKKKCKKKIKK)KKKKKK>KKKKJGKKKKKKKKKIKKKKKKKK;KKJKIKKKBKKKKKKJKKKKKKKKKKKKJKEKKJKBKKKKKJKKIJKEJKKKK@KEKKKK=KFIKKKKKKKIKKKFKKKKKKIJKKKKKKGHH=DKK@IKKJ:IJK@KKK@KJKKKKIKKKKJKKKKKJJIKKKKJK>JKKKKKKAKKIKKKKGKKKDJKKCKK>KH?KKKI3%D>AKIKKKKKJKJKEKBKFKKKKKKJKKKKKKKIKKKKKJKKKKKKKKKKKJKJKKJKKJKKHKKKKKKKKKIKKJKKDKIKDKKKKKK&KKKKKKKKKFJK@KK:KKKKKKKKKKJK?KGKJJJEKKJKEIDEJJK3C7J9F?KKKKKKKKKKKKEKKKHKIKKKKJKKKKKEKKKKKKKKIKJKKKK=KKKKKKKKKKKKKKKFKKKKKKKKKKKKKIKKKKKKKKKKFKKKKKFKBKJKHKKKKDKKIKKKKKKKKHGG/IEFI-KEKJKKJIK3KKJKK9KDKKJJIBKKKKK?KKKIKKJJKKIKKGKIKJKKJKJKKKKJKKI=JKKKKAKKHKKJKKKHKKKKKFIJKKK=KK7KKIJK,IJIA@KKJJKKKK?GKK(KKKKKKKCKJK>KGKKKGKGJKJKKEIKJKKBKKKJKKJKKDIKIJKIKKKKJIJJJJKJKIKKK;KHKCKKKKKKJI(IJAHKK4KCIKGJJJGJIKKK7KKEKIIIIKK7KF?K=KIJEIKGJHJ@KHIKKKKJKKKJKKKKIEGIKIKFKHKKK:KK2GJK3JKKCKKKKKK2KKKIKKBKKJKKJKKKF.IJKKKIKHBK9KDJJKAKIKKGKKBGHJJAKKKIK1KKK@IK*KF7AKKJK=KJIJKHHK7K;KKKKJKIJKEKKKKGKEKJJKIJKJIJJK6JIJKJKJKKKBKGKJKJK@KKKKKKKJKKKKHKGJKKCJIKKKJKKKEFKKKIKKAIKKK?KK=2*;86-765<+<89=7=><*812331&<21-57+$73799:68;;9<79:86'6-01;4;3%7>BA=?B=@847,56;B@@6;>36:=8;>?B>>9=@?>:=(;8<4=><5==44C=5:-=?;?<<27=<>=:>97>4==534<-9-59;6:+%647:75-;1@74<9:.A?+5;5;6<;:;BA:=2>0%>=@;7<=?@A33,,577-37>:'86>9<<88@A@A8<7.6:=<719:5<67/6<;1;67@89=97<7B:?C79::74;7@;?8>22<1548?EA@?*9>;79B::?<@9=BDB0=;2AE==4?A>:9.:864@30=<;FFAF979?88;B2-;7;7=CCE;B@9E7BD=?3<==912&;:75:4929@:73:4:7.>;2)8>>?,AC<58?D8EE?2B@>92BA%>941==+B/<2:?224<95F><>A@A>:;D4=,3631$*8;:?9;093=4@?C170@><4&><;;:7A=6376/<57@C@399><6312;>7;@;5AE/C5>>D&??FA4BBF?C6FBCDFF-AB4@>>CAC8B:EDB?@B@D@C>B3A;8/A@7CF3BB@42BCB988??B@0?88=?2BAE5='>?DC;?6=34;7@416-69)76<4@-9A:99 @rCer/190/1897_63_CCS ATTGGGAGAAAGCGCAGGCGCAGCGGGTTGGGTGGCAGCAGCATCGAGTAGCGGCCGGTTTGCGCAACATCCGCAACAGGTGTAGACAAATCCCGCCTGACTCCGCCCTGGAAAGTCCTTTTGAAGAAATGGCCCTGGTGAGGGCGGCTGGCTGTGGAGACAGAGCTCCATCCTCCGCCGCTGGAAGCGGAACTGGTTTGCCTGTGGCTGGACGGGACCCTGGGATACTACCACGATGAGACAGCTCAGGACGAGGAGGACCGTGTGCTCATCCACTTCAATGTCCGTGACATAAAGATCGGCAAGAGTGCCATGATGTGCAGCCCCAGAGGGCCGGAGCCGAGATGGCCTGCTAACTGTGAACTACGGGAAGGCGGCCGCTGCACCTCTGTGCGGAGACCAGGGATGATGCCCTAGCATGGAAGACAGCGCTGCTGGAGGCAAACTCCACCCCGGTGCGTGTCTACAGCCCGTACCAAGACTACTACGAGGTGGTGCCCCCAACGCACACGAAGCCACGTATGTCCGCAGCTACTACGGACCGCCCTACGCAGGCCCCGGCGTGACGCATGTGATAGTGCGGGAGGATCCCTGCTACAGCACCGGCGCCCTCTGGCCATGGGCATGCTTGCGGGAGCCGCCACTGGGCGGCGCTTGGCTCGCTCATGTGGTCGCCCTGCTGTTCTGAGCCCTGGGACCTGCAGCACTGGCCCCTGCGCTTGGACTGCTAGACTTTCTTCCTCCTGGACCCCGCCTCTACCATCCAAGCCCTGTCCCACTTTGGCCCTCTCCTCTCCATTAGCTCCTTCCGGGTTTGGACCATTCCCCCCACTCCCTACCTCACTCCCACATGGGAAGAAGCTGTCATCCAGTACAAATGTCGCTTGAAGTCTTCACATCTACTGCAGACACCCCCAAATCTGTTATAGGCATTTATGGATACATTTCCTCTAAACACACCAGGGCACAGCAAATACGACTTCATTTGCTTCGAGTTCCGTAGACACGACATGAATCGGCTCTCTGCTCTCTCGTCAGGGAGCTGGAGGCCTGGTGGGGAGAACAGGAGTAAACAAGAACTTGACAAAGCTGCAGAGTTATCAGTCCTTTGACAGGGACAGGTGGGGCAGAGAAGCAAGGCAGGTAGGCTGGAAGAACAGTTATTGGCAAGTGTGCAGAGCCATGAACGTCATGGCATGTCCAAGAATTAAATGGGAGTTTCATCTGGCCTGGGTGGAGGCCAGGATCAGACCATGGTGGCCTTCTAGATAAGGAGCTTCCTGGGTGAAAGGGAGATGTGAACGTTCCCTGGAGGGAAGTTCATGATTGCATCTATAATATATTGCCTGTTTTGTGAATATTGACATACGTCCATACCCAAAACCCCTGCCCACAACCAGCTTCTGGCTGGTACCCATGATAATAATTGAGCTGAACCTTGGGCCCTCGTTGGGGAACAGGTGATTCTATTTGAGACTTCTAGCCCAGAAAAACTGCCTCAGTCCGGAAATGGCTCTCATACCAGGAGCTCGGCCCCTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGGAGATGGCAGTGTTCTTCTCTGGGGCCTGATCCACCTTTACACCAGCCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCTTTCTATCCCAATCACCAACAGAATGCTAACATCCCTGCCTGTAGCCAGACTAGCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAAAAAGATTTGGTTG + %##)(''&((%((()()(&'%$(&%'%)%()&%&(('(''$$((()&''%#$&$$$&$,,$#"(+'(*'+*,(&+&,,'&,,,+((,'$')01).0--,5.21&136425/.-%/-2-152+31&154*51*52*-2541//4&41+25603).01*,*/0+4.4555.455+56110(%,56466522,3-0-3060012$/015/43322566,15)..0+(-1,50$4-26512054.11+-/0061554/3,,..,**)*+))340/0623/1%,0&/-),+.32/15/14)02254)$.1562422/-./41,1.+1**.(#,-*-2,,.-,302/4+02,6++).*,(&&0-,%-*%"$*/15/3(0.00%,&('0,)(+&*-&+/..1*./)-()&)#)$)'((')(*/-.//+.,,./34001///*522462.54.531,((/-%/,1'1113510264121,36/6103.42242.0,1)+../../2.0.*4/)+*231134)45///3224005553+04651/4/.'-60/34/1-23/562.20/2-1//1+4505313/*2502441,&44+,5*)$.1413/'0-,,%0+2061*)/26/3&5565+-0-3/3101621126534)2.0-0'3515644.2(+441*(51,02112,5.0/1141)5425564662/03&3312,-*11-4430562+0/-.-642/4656/2.4-%11#/013/405/104331()#(0/,52*51/22,+54.31001-136-55064/'%(0,-124/&0%.0,5/+516543'31+4+0333+./..,0(3.(-4(+,50,14.152(0.14/.*-(*2*2)+0454('$+#.&/55/55.254/*-3)/155/4)464,3350.$.53401343(54*0403-003***0--..-.20/-1.*,-.,*,'.43,-)1+4/114*54./205202/540062-304,%-50111/,-1)422143353102300'0.5#0/-/3434,*4110,24022+1342630/*,&.2/&*($(*,*+01*-')/36155*43221/153/,)3.32260246/1-51/44+4/225+166.213/,1121'-&&/2-'3560652+)%/-11540,3.(%.1400*('*3+-0),.44).).2./(..))%..0045003*5514,+-%))*)/(/30-*-.*-'(.0-/+)*#0*/)-.1/1*1)/5)0/-)-/.*.+/,)/'))1.52.+)-40.%+(/2.0./41%0*44*/0$'*+45523)-14/04/561-13,10-1)2-/014-5532+)00-*,0))3/56+5//4/$..3324/511/3/0.1+-1++/.5406+),'.+)0455'&/3*-%3*46,$1610141154/*01/*-*&(+)+'44+521.*1,1/11&4/%,-/1+'..$2/05,(.1#%&0104-(+3.0+*.20))32&135462-02-+'.-+)//)0.-3)45,10/(201/.*/40,&&*0/(,))#),/$.1-/*,1+*-**00,*.3.('&.54255,.3.2240/1*-'/*--*-..-)'#%/22.-/.433&)2-0/+.'%,#63).)43/(+,0'*,(/-/-+.*'',./,--.1'0*010-10*0122/11/1-01*).,+,**-//(110$/+'1/.,(&%-)-'(%----+%*/.*220111122-0(/,,--.,,)%*$00-*-,,)011)100-/,01--+'$*)1,'0&//.+1,1-//-&0/*,+$(*+)()*&)*00+**0(-*--*&((')--+(%"'*&#%#%%)',(+ @rCer/191/555_87_CCS TGTTACCACAAGTCTTTTTCAATTTCTCAATATTATGAGAACTTAGATGTATCTGTTTAGTTTCCTGTCTAAGAAAAGGTTTAACAGATCAAATGTTTCAATAAGTTGTATAAACAACCAAGAAAGTAACAAAAATGAAAAGAAGATAATTAAATAAAAAGATAAAATCTATCAATATGGGCCTGGGGCGGGATAACAACATTATATCACAGCCATTTGCAGGCTGATGGCGATGAATCACTTTATTAGCCGGGAGTTCAACCAGTCTGCGCGACAGTGGGAAACTCCCGTCTCTACTTAAAATACATAAGTTTAGCGCTGGCGTGGTGGTATGGGCGCCTATGTAATTCCAGCTAGCGGGGGGGCAGATGCAGAATTGCTTAAAAACCTGGGAAGTGGAGTGTTCAGTGCCGGGATCGCATCACTGGCTCCAACCTGAGGTGAAAGATGAGGACTCAATCTAAAAAT + '+"',*+--)$+)$(')*)--&$*##**&--,#$+-&,&'+-))."'/(%$,$+#%$'.-.%"-+&-*-,-$#+%#,"'"+(.%-.'%--,*--.#*',..-'++'#(**%-%&-',-+$,-#(+,*,%#$,*',.+$%#*",(&+"+$.(-)$,-(+*+,."(#'&-+'#+,&&)#'#)$(*#*&"&%'"##&*+,+&.".**%)/*%*+,"'#)%%#&)")(,--",'+*&,&"*.,,'.((-"#-.*/-)%+,"(-#+(,...#-/+-*.-'&##%$(+#+,")*+-.#'"-.+",&-,...--"*-,"%%**%"$-()&+(#'-+&-##-*&.,&)#".#+-'.*.+-...&"%"#'%#('%,..",$.*,+-$-(-)'%*#+,".+)&$&(.-'')$+.(+-.-+)%'*)+,--**/-*,..%*'-*++*'-#",(../#*,(/..,'))/..,.*.)*(('# @rCer/192/25_2051_CCS ATGGGTTCCGGTGCCTGCAGAGCTCGGAGCGGCGGAGGCACCGACCGAGGCTGCACCGGCAGAGGCTGCAGGGCGGACGCGCGGGCCGGCGCAGCCATGGTGAAGATTAGCTTCCAGCCCGCCGTGGCTGGCGTCAAGGGCGACAAGGCTGACAAGGCGTCGGCGTCGGCCCCGGCGCCGGCCTCGGCCACCGAGATCCTGCTGACGCCGGCTAGGGAGGAGCAGCCCCACAACATCGATCCAAGAGGGGGGTTCGGTGGGCGGTGTGTGCTACCTGTCAATGGCATGGTCGTGCTGCTCATGGGCCTGGTGTTCGCCTCCGTCTACATCTACAGATACTTCTTCCTTGCGCAGCTGGCCCGAGATAACTTCTTCCGCTGTGGTGTGCTGTATGAGGACTCCCTGTCCTCCCAGGTCCGGACTCAGATGGAGCTGGAAGAGGACGTGAAAATCTACCTCGACGAGAACTACGAGCGCATCAATGTGCCTGTGCCCAGTTTGGTGGCGGTGATCCTGCAGACATCATCCATGACTTCCAGCGGGGTCTGACCGCATACCATGACATCTCCCTGGACAAGTGCTACGTCATCGAGCTCAACACCACCATCGTGCTGCCCCCTCGCAACTTCTGGGAGCTCCTCATGAACGTGAAGAGAGGGACCTACCTCCCACAGACGTACATCATCCAGGAGGAGATGGTGGTCACAGAGCACGTCAGTGACAAGGAGGCCCTGGGGTCCTTCATCTACCACCTGTGCAACGGGAAAGACACCTACCGGCTCCGGCGCCGGGCAACGCGGAGGCGGATCAACAAGCGAGGGCCAAGAACTGCAACGCCATCCGCCACTTCGAGAACACCTTCGTGGTGGAGACGCTCATCTGTGGGTGGTGTGAGGCCCCCCTCACCCAGAACCCCCTGCCGTCTTCCTCTTTTCTTATTTCCGGCCACTCTCTGGCCCTCCTCCTTCCCCCTGCTTAGCTTGTACTTTGGACGCGTTTCTGTAGAGGTGACATGTCTCTCCATTCCTCTGCAACCCTGCCTGCCTCCCTGTACCAGAGCCGTGATCTCTCTGGGGGCCCCATCTCTGCTGACCTCCTGGGTGTGGCGGAGGGAGAGGGATGCCACAAAATGTTTCTGTGTCCCACTGTCTTGAAGCTGGGCCTGCCAAAGCCTGGGCCCACAGTTGCACTGACAGCCCAAGGGGAAGGACCAGTTGGGGGAGCTGCGCATGTGAGGCCCTGGGCAAGGGGTAGGGCTAGGGGTGCGGCATGGGCTTCAGAATATCTGCACAATTAGAAAGGTCCCCAAAAGCTTTTCCTTGGAGGGTACACTTTCTTCACTGTCCCTATTCCTAGACCTGGGCTTGAGCTGAGGATGGACCACGTGCCCAGGGATGGACCCACCAGAGCACAAGGGAAGGTGACTGCCTGGGGTGTCCCGGGACTCCTGTCAGTGCCTTCAGCCCACCAGCAGGAGCCTGGAGTTTGGGGAGTGGGGATGAGTCTGTCAAGCACAATTGTTCTCTTGAGTGGAACCAAAGAAGCAAGGAGCTAGGACCCCCAGTCCTGCGCCCAGGAGCACAAGCAGGGTCCCCGCAGCCAAGGCAGTGGGATGGGCTGCTGAGGAACGGGGCAGGCAAGGTCACTGCTCAGTCATGTCCACGGGCAACGAGCCGTGGGTTCTGCTGAGTAGGTGGAGCTCGTTGCTTTCTCCAAGCTTGGAACTGTTTTGAAAGATAACACGAGGGAAAGGGAGAGCCACCTGGTACTTGTCCACCCTGCCTCCTCTGTTCTGAAATTCCATCCCCCTCAGCTTAGGGAATGCACCTGTTTCCCTTTCCTCCTCACTTTTGCATGTTTTTACTGATCATTCGATATGCTAACCGTTCTCAGCCCTGAGCCTTGGAGAGGAGGGCTGTAATACCTCCAGTCAGTCTCTGGGATGAAACTCTTAAATGCTTTGTATATTTTCTCAATTAGATGTCTTTTCAGAAGTGTCTGTAGAACAATAAAAATCTTTTACTTC + D>)CFEHKGH;JJH5ED>EKJ<>IIFJJ=J9KKKJJKAIJKEGDEHEKIKHFIIEHHJ?F@K4KJJDJ@HF/JIH2HFHEEB>HIK8KFA:;JIA%J><;+JJKIFJHB:IIABC$EFIK=CKBD=JIKBKFFKGHKGGGIJGGIJEBAHHHHHAEIIK=CKKJJIJJIEHCJKJJJFG;E/FKF?F?GGJAE?@FBCA9CGJ?AKIK9IIGE?IGCFG*HD?HKI8IG>G?KHEHHEIKGBFF@EH9IBKG>9FGJFGEEKJJCDJIKGJIIIKFJF5@GEHJEBCIFIBHF?CHIDKKGHJFJFDCAH$C9>>BFEFAKJIKICHDG@GDIKIFJGGKGB9KFFHHIDJHIKIFI@KGJI.7CEIFCFIIFBC@>I?E?$@999ICBHID=I+JKKKHF6KKKJ:KFIHJHGHGHF>:JJFHJ;KHDEGHI9KJIG;HJ8KIIJK.KDDCIH2KK'KIFFEF6FEGJ>FKGBIE0>6FCG?JH:IG'EGI8IKJII)JJKGK4I7EA&BBC@DE=%G@C@FE>KFHFGH+HKJ0KKH;0KG+IIIHK?6HKGAHIJKIBEHBE@A@GIEKJCFJ;E:CE;@CFF=I>?HEAJEI?:6@>;B?7FHDHGHEAHHI;@$EC>?JFDD>D8>FEI>HHDAFEHFHGDBH8?1:3BD'CA>>B9:@E,<7JE*HEEBDBJE?A1FFDAA<;EDAFIH?=7C@@H?G.JJF1HEI7=?GIH1IBE>JHIAC5E8AE7GA@DE>E'DFB6H60GAFI?DF7E?A?D6H@AHBJJEI8EGE8GJGJHIFC@BEC*BCAHD?E?EIIB1BB7HI1GJDIBDJIIIF3JJGCBFIG3IHHIGEIIHFII>HEGEGI?=@IAJCI??H@A?875EHIGIDFIDH.EBGA4G4'?CA>??IJD;H9G(FDABGDCA-?;-EC@DD+AEGGCE(HDEFI:JI @rCer/193/1857_55_CCS ATGGGGACCGCCGAGGACCGCGTCCGCCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCCGGTGACGGGGTCACCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGAGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTTCCAAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACAGTGCTGTCCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATTCATTGCTCCTCCTGAGCCGCAAACTCCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGGACGAGTCTGGCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAACAAGATGAGAATATGGCATGGCTTTATTTGTTTTTTTTGTTTGTTTTGGTTTTTTTTTGGCTTGACTCAGGATTTAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCTCCTAAAAGCCACCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACAC + .*01.,./,*1*/,,&,.'+'.+.'*('')#011.,1,110,*')&()0($)$$'('.*,&.2/1/,/(/20.++,,-%%0*+-,%'%)),)&**-&,$(11/+/**&&())(.()',,'-00-.+('#.2,+,1'-*$)+,,.*-%.-((,***$(,+00,-.+/*.'&%%(*$-/(+,*--))+.-')0*./1-/010%)/.0-*%-%+/0*,,/%*/(.++)#)&-$)('//++*-(0--$'(,.11/,/10/,//0)*//)0(+',-,,,,'.,)*(+(,.(+.01..,.(*-*)*),&,245150/.0(/+-/4463340)./2-**'&&+,,*,+,&*,*.0+430.601.+1144221//*00.+-/-/0+&/22.-)3-5-03.5111431%*-,1433/-4246-0/0111*,,'/-342*,'4$,+%',+'**-))%%((,)%)+-,.(&&*/.-.&.,-+0'/,+0*-/),0..12/,,.,,&+0,*,**+-/.2/+.,)/,&//...+0-1/*/*(.(//,,***()*()/%*(&'.,(,12,'//*+%.-+00.0,/'(('+$+--'')&'-2-'#%%,,+,()(%##&').'.++*)%+,--)'&''----++')**-*+,%)(,++*'')%00).,-/-0))+/.'0//-/2.,.*.,.,+*'-,--*.*'(),0--'-,-0+**,&(+-,0-,/-/0(-/*,+--)(,-,*(-/0('.$0,/+1).+*.%*++.,/-,-(-0+&*%/2./-0,/++&/'(%-*1,.*,&,1.)-%&&)/012/-,-(1.-,/*(-,/+0)1000-0,+)$)&/--+1,0.-//0,0/'%+1*.-,.'.,/0+0+././)+02/-*-010+),,**#1-*+'+*1&/,/0++,//)(',-(($&+(+*(.&'&00-'.0/.)0.02/.+*,&+(*$#,+&)0-+*.110/.,(-&,*((0*/)+*%''/,'00.,))&)((%/*0.10-''-0++2-/)+)'+'%,-,*/+*+/()(($.(*+++-0/*(,&(12..,1.%+&#...*%&+00-(++''-,'*-'(+-*)(,+-*+)%#*+'''(),%(,&,)$'#",(%"'%"&%$%(+))'+)*)'&)+*).+(%(*+,)*(,(+),(()#''*'()-(','-*&&*'-)-)+,+-.---+)&&,)())&%&'$$()-*))$%%*&)+*-(,%'+*--))(+'('&++(,++()-,*$#+,-+))(,,),-*'$&)'(*%)*$*+()&#$#%$%&)*+,.,--+&+(*,#$)')'&*+''%&#$,',++(%&-.,+)(%&)+,,,,,#%*+$,1.2-*,-/.0.0-1',*)(&/-.,,/+,)*(%*/,$)/2.)&,*-.$,-/***/1.0-/1.12-2..(-,/*-++*%)/11'/.,,2.,+/,-11112+0*&(,,,,+.++*+,0,.-/.&+(%,.../-.,#,).+-,)0/)1.'0*+))++-')(.'.0./*(/.0.2+*..,'01+1%+2,/022,.1*+/,%.-+**&*-0*/.-,1/,'-/)1-*,/),-0/+.*('.002,0+/012201-,'&/.*(1.,.*,1/01..)#0,--%.(,.&)*(*.,,,,$,.,-,/$,)(/21110,0+)*.,-+-,+)&+./)%#$-0#%.--++.,,&'()+./(,#,*+./1--*0-/.,0*/(*,-*&/)./+1.101/0+-,2..0+//-%0).,+/0)+11*),/*/-*,-,2/01,--00+%%(%,+//+-0-*-/-0121,)%+,+,-2001,0/1,),/111./. @rCer/195/0_775_CCS GTGGGCTTCAATGTCAAGAATGTTGGTCTGTCAAGGATGTTCGTCGTGGCAACGTTTGCTGGTGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCCAGGCCAAATAAGTGCTGGCTTATGCCCCTGTGTTGGATTGCCACACAGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAGATTGATCGCCGTTCTGGTAAAAAACTGGAAGATGGCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCTATGTGTGTTGAGAGCTTCTCAGACTATCCACCTTTGGGTCGCTTTGCTGTTCGTGATATGAGGCAGGAGCAGTTGCGGTTGGGTGTCATCAAAGCAGTGGACAAGAAGGGCTGCTGGAGCTGGCAAGGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAAGATACCTGCCACCCCACTCTTAATCAGTGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTATAAGTTTAGTTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGAGAAGAATGTTTTGTGACCACTTTGGTTTTCTCTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTTAAAATCAGTACTTTTTTAATGGAAACAACTTGAGCCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTTAATG + S(%))#%('$&&(('"#"$'++%))))'(+*&*-,.-+-*-)*,+,-+-((''($++*(,+.)++-+-,%+&*+*+)',,)'*'(+&,)-+-***((,))++&&*+,+,+**-+$',-,/./,)/+1.0$+))*)'(,,./'/00-1-,21%-.*,-2201)+111.())0-,1.++),((-0/,-*00+(-1+'10)-/..%+1**/1.2/.$*)''+0-+'.002-/2(',01.20,.201*../%&**+)0.,%--+1-10/%.(,/,-0)**,%*,0+0,++&'-,+,-())'*).,)-,%)$$**)+.&,..(.+-*%(&%+'',)-//.-+$(+-,-.1'+-.01/$/,..*/,1(%&(,.,()$$&&'%&%%%,*.,%$((#")./,,/*0*%),+0/1/1,/,&'-))-$('*/.'+.,**,+%&('-+/.-+%)&,-,(+'$),,+$+'('*,(*%(&'###$%&+$&'*+,+(%'%)'%%)(+&($*+-(()(++,)(,..+$#(%&$-.,((&*/.&+)(+.,/+0+,,$'()*)0+)/),.0-21'(0%&,,+#(&'($%//-*1-./-+%%*%.,-*.,.'&#$%)++,(+'$*1*-*+)+,'((.%)(,1*$*&+,/./0,-*,,,*,..&-)(-)/*/00'*"%)//,..,000(-,*(&-.,'*0*+%**&($%*')$#'('*&(+&&%&(+(,*&*+(*)+,+)(+&,''$((#)'')().+&')'*&%%"('(')*&#&$&$&$++&&**#)'**++ @rCer/197/0_2302_CCS CTCCGCTGCGCGTGGATTTCTGCTGCAGAACGGATAGCCATGGCCAACCAGCACAGGGTGCAAATACCGGGCTCCATCCTGACTTCCCAGCTTTGCCCCAACCAGGATGCTGAGGCTCGTACACTGCATGAAGGCTTGGCAGTGACAAGGAGGCATACTGACATAATCACCTCCGGACAACAGCAGATGGCAGGGAATCTGTCAGAGCTACAAGTCCCTCTACGGCAAGGACCTTCATTGCTGATTTAAAGTATGAATTGACGGGCAAGTTTGAACGCTGATTGTGGCCTGATGAGACCACCTGCCTATTGTGATGCCAAAGAAATTAAAGATGCCATCTCGGGCATGGCACTGATGAAAAGTTCTCATTGAGATCTTGGCTTCCCGACCAATGAGCAGATGCACCAGCTGGTGGCAGCATACAAGATGCCTACGAGCGGGACCTGGAGCTGACATCATCGGCGACACCTCTGGCCCTTCCAGAGATGCTTTGGTCCTGCTCCAGGAACCAGGGAGGAGGATGATGTAGTGAGCGAGGATCTGGTACAACAGGATTCCAGACCTATACGAGCAGGGGAACTGAAATGGGGAACAGATGAAGCCAGTTCATTTACACTTGGAAATCGCAGCAAGCAGCATCTTCGGTTGGTGTTCGATGAGTATCTGAAGACCACAGGGAAGCCGATCGAAGCAGCATCCGAGGGAGCTGTCTGGGGACTTTGAGAAGCTGATGCTGGCCGTAGTGAAATGTATCGGAGCACCCCGAATATTTTGCTGAAAGGCTCTTCAAGGCTATGAAGGGCCTGGGGACTCGGGACAACACCTCATCCGCATCATGGTCTCCCGTAGTGAGCTGGACATGCTTGACATTCGGAGATCTTCCGGACCAAGTATGAGAAGCCCTCTACAGCAATGATCAAGAATGACACCTCTGGCGAGTACAAGAAGTCTCTACTGAAGCTGTGTGGGGAGATGATGATGCTGCTGGCCAGTTCTTCCCGGAGCAGCGCAGGTGGCCTATCAGATGTGGGAACTTAGTGCAGTGGCCGAGTAGAGCTGAAGGGAACTGTGCGCCCAGCCAATGACTTCAACCTGATGCAGATGCCAAGCGCTGCGGAAAGCCATGAAGGGACTCGGGACTGACGAAGATACAATCATCGATATCATCACACACCGCAGCAATGCCCAGCGGCAGCAGATCCGGCAGACCTTCAAGTCTCACTTTGGCCGGGACTAATGAGTGACCTGAATCTGAGATCTCTGGAGACCTGGCAGGCTGATCTGGGGCTCATGATGCCACCGGCCCATTACGATGCCAAGCAGTTGAAGAAGCCATGGAGGGAGCCGGCACAGATGAAAAGGCTCTTATTGAAATCCTGGCCACTCGGACCAATGCCGAAATTCGGGCCATCAATGAGGCCTATAAGGAGACTATCACAAGTCCCTGGAGGATGCTCTGAGCTCAGACACATCCGGCCACTTCAGGAGGATCCTCATTCTCTGCCACGGGAATCGTGAGGAGGAGGAGAAAACCTGGACAGGCACGGGAAGATGCCCAGGTGGCTGCTGAGATCTTGGAAATAGCAGACACACCCAGCGGAGACAAAACTTCCTTGGAGACACGGTTCATGACGATCCTGTGTACCCGGACTATCGCACCTCCGGAGAGCTTCCAGAGTTCATCAAGATGACCAACTATGACGTGGAGCACACCAACAAGAAGGAGATGTCTGGGGATGTCAGGACGCATTCGTGGCATTGTTCAAAGTGTCAAGAACAAACCCTCTTCTTTGCCGACAAACTTACAATCCATGAAGGGTGCTGGCACAGATAGAAGACTCTCACCAGGATCATGGTCTCCCGCAGTGAGATTTGACCTGCCAACATCGGCGGGAATTCATTGAGAATACGACAAGTCTCTCCACCAACCATTGAGGTGACACTCCGGAGACTTCCTGAAGGCCTTGCTGCTCTCTGTGGTGGCGAGGACTAGGGCCACAGCTTGGTGGCACCTCTGCCAAGAAATGTCATCAGCACAGCCGCCACGGCCAGCCTGATTGTTCAGCTCCAGAGACTAAGAAGGGCAGGGTGGGAGGGTTGAGGTTGGGCTCTTATCTTCAGTGGAGCTAGGAGAGGCTCCACTCCCACGGGCATCGAAGGCCAGCACGACGAGCGACTGAAAACCGTAGCATAGATCCTGTCCACCTCCACTCCCTCTGACTCTCAGCTTCCAGCTCCTCCCCTTGCTACAGCCTCTGCCTGGTTTGGCTATGTCAGATCCAAAACATCCTGAACTCTGTCG 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@rCer/201/1659_58_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACACTTTCTTTGACCCCGTTGGGGGGAGATCCTATCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTT 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rCer/204/2657_63_CCS ATGGGGGGGGCGCGGGCGATTTGTAGGTAATGGCGGGCGTTCGGGCCCTGAGGTGCAGCAGAGGATGCGCTGGCGGCTGTGAGTGCGGCGACAAGGGCAAGGGCAGCGACTCCTCGCTGTTGGGCAAGAGGACTCTCCGAAGACTCGAGCCGCCACCAGCTGCTGCAGAAAGTGGGCGAGCATGTGGAGCTCCGTGAGCGAAGACGCGTCGGTGGCCGACACGGAGAAGGCGCGGCTCGAGGGAGGCGGGGGGCTGCGGAGGAGAGGCCCGCTGGTGTTCCTGTGCTGCCGGCTGCGGCGGCCCGCTGGGCGACTCGCTGAGCTGGGTGGCCAGCCAGGAGGACACCCAACTGCATCCTGCTGCGCTGTCAGTTGGGTCGAGCCGGGCATGGGGGCGTGGGGTCGCCTTCTTCAGGTTGTGCCGCGCCGGGGCGGCCCCGGAGGGGGCCGGGGGCCCTTTGGCGCTGTTCCAGGGACTTTGAGAGCAAAAAGTCTGAGAGTGTGAGCTGTCGCAGGAAAAGGGGAGGAGGGTCACCCCTCCACCTTTGGTTCTCGGGCGACTGGTTCTGTTCTGGGCTCCCCCGATCCCAGAAGAGCACGGGTTGAGTCAGCATCATCGTGAGCATTTACTCAGAAGCAAAGGCAACAAAGAATAACACTTTTAAAGACCCTAAAAAAAAAAGAGAAACAAATGGTCAACTAGACCGTAAGCACTTGAGGTGCAGCCAGTACTATTACTCCCCACAGAAATTAGCGGGCTGGTGTATCAGCGGATACCTCTACAGTCTCCAGTGATAGGGGCCGCGGAGCTGACGGAACACAGTGCTATGGGGAAGAAAGGGAAGGAAATTTGCCGTAAAAGCACCACCAACCTCATCAAAAAATTGGCGGAGGAAGGAGGACGTAGCAAAAAGAGTTCAGAAGGTGTTTCCTGTAATGTTTCTGTGGATAAGGAACAGAAGTTATCCAAACGTGAAAAGGAAAATGGTTGCATCCTGGGAGACTTTGTACTGTGCAGGGTGCTCGCTCAATCTTGGCTACGTGTACAGATGCACGCCCAAGAATCTTGATTACAAGAGAGACTTGTTTTGCCTCAGTGTTGAAGCCATTGAAAGGTAAGTTTGATATATAAATGTTTACCTCACAACTGGTGTTTCAGAAAGTTAAGTTTGCAGAGAAATTGGCACGGAAGTGTCCGAACTAAATCAATACTGTTTGGTTAAATATATTTTCAAGTAATGATTTTCTAACAAAGCCAGTAATTTTTTTTTTTTTTTTTTTTTTGCTTTGACCTGCTTCTTTATTTGGTATTGGAAAAAGTCAGACACTCTAAATTGTAGGAGAAAACACTGTGAGAAATTTTTTGGAAATAAAAGTATATTCAGTTGTTTTTAAAAAATTGAATTGTAGTTTAGGTAGGATTTTGCCCACCGCCCCTAGCTTTTTATTTTATTTCTTTTAAAACTTATTTTTTTAAGATATGGGGTCTCACTCTGTCACCCAGGCTGGAGTGGCAATGCTGTGGTCATAGCTTTCTGTGTCCTTGAACTCCTGGGCTCCAGCAATCCTCTTGCGTCAGCCTCCCCAGGCAGCTAAGACAACAGGCGTATTGCCTGGGGTCTTGTGTTGCCCAGGCTGGTTTCAAACTCCTAGCCTCAGATGATCCTTCTGTCTCAGCCTCCTGAATAGCTGGGAACAAGTGCATGCCACCACACCAGGCTTGTATTTTTACCTTGTACCATACGTCAGTTATGTTTTTTAGGGTCCTCTGAAAAGCAAATTTGTGTCAGAAGATAAAGAGCTTTTTAAATCTTGAAAGCCAGAGTTGAAATAGAAAAGTCTCTAAACACAGGTAATTTTATTCTGTACGTTTTGTATCTCTGTATGAACAATTTGTCAGTGAAGAAGTGCTTCCCCCACAAACGATATTCTCATAACGTCATCTGTCTTGATCGCAGAAGAGTGTGCCTGTTTCATTTCAGGTGTTAGTAAAGTTGATTTTTGGGGAACTCAAATGAAGCTAAAGCTTAATTCAACAAAATATAAGACATTTCATGACAAAATCAAAACTATGTATTCTAATTTTGCTAAGTAAGAAATACTCTTTGATTCAAATCAGTATTTTGTTTGCTTCGATTCTTTGTGGTATAAATAGCCTTGTTGTTGGATGTTAACATTTTGTCATGGCCAGAATAGGTGAGATGGTGATGATTGTATAAAAGAGTGCAGATTGTAGGTTGAGAACTATGTTGATAGAATTATGCTTTATTTTAAAAATTTATGCCTGCAAATAGTTTTGGTAAAACACTGAATATCTACCATGTAATGTATGACATATCCAAATTGCATTAAGTGTATATCTTAATTATTTTTAACCATGTATAATTTAAATGATATGTGTGTTTAATTTTTATTTTTCAATTCAATAGAATGGAAGATGTCTTGAAAGCATTACAAATGAAGCTGTGGGAAGGCCGAATCAAAATGTCCTTTTGCCACTTGTAAAAGCTGAACTCTAGTCTGTGTCCTCCATTCTGCCCCCGCCCTTCCTCCCCTTATTTGTTAAATGAAGCACATAGTGAGACGTCGTCTCT 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@rCer/205/1801_60_CCS ATGGGGAGTCCGAGACGGTATGGCTGCGGCACTTCGGCCCTCGAGTCGAGTTCTCCTGCAGGCATCGCAGATTTCGATGTATCCTGGGTGGGAGGCTCCGGCTCCGTCAGCTGCCGCTGCCCTCTCGGAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATAAAAGAATTTCAGCAAAAGAAAGTGGCTGTTGCATGCAGTCTTCCTGGCACTAAAGAAACCTATTTAGAACTTGAAAGAGAAGCTGACCCAGAACAAGCTCATCTTGAAGGAGGAGTTGATAACCTTACTTCATTTGTGTGAGTCCCGGGACCACGTGGAGCTGGCTAAAGATGTCATTTACAGGTACCATGCAGAGAACAAAAATATCACTTTGGGGGTATAAGTTTGGACCGCTTTTTTGTGAGGCTGTGTACGAGTTGGATCTCGACGAATCGCAGTGGAGTTCTTGAAAGACCAGCATTACGAGGTTTCTTCTCAGACTCCACATCATTCAATATTTTGATGGACATGTTATTTATCAAAGGCAAATATGAAAAGTGCTTGGAAGTATTGATAGAGATGAAAACCAAGATGTGAAGTTCACGAAAGATACCTATGTTCTTGCTTTGCAATTTGCTACAAACGAATAGCCTGAGTCTTCAAAATCTGTACTACATTAAGAGAAGAGCTCTACTCAAAGGAGAAATTCTCTCCAGGAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGATCAGAATGAGTTGGCAAAAGCTGTGTCCATTTTTCTCAAATCATGAATCCAGAAAGCATAGCCTGCACTAATTTAAATGTATAATCCATATCCAGTCAAATGCATTGGAAACCTGATAGAGACTCTAACAAATGCTGCGGAAGGAAATTTATCAAATTTGTGAAAAGACATATGTTCTCAGAGGAAGTGCTGGCCAAAGTGAGAGAAAAGTGAAGGATGTGCCTGCCCTGTGGCCAAATTTGATGAGATCTATGGGAAACTACACATCAGTGGCCAGGTCACCAATTATTCTTTGGATGCTGTGCTCTGCTACACCCCAGGGACAAGAAATCCCACACATGCTGTTAAACAAGAGGATGGTCAGCCGTCGCACCTTCCGGCCACTCAACCAGTCCCTGTTGGCTGAGTAACCTGGTTTCAGTCCACCTATGGATCTGAGGGGCCTGCTTCTAGTGAGTTATTGCCTTTCCTAAGAAGTCAGGCATCGCACTTCAGCAGACACTGTACTGACACTTGGTCTCCTCCTGAAATTCCCAGATTCACTGAATGGTACCATGCCGACCTGTGAGAAGTTATGTTGCATCACTGTGAGGTCTAGATGCAAGCTTGGCTCCCTCAGAAAGGCGCTTCCCTTTGCACTGCTGAGGATCTTTGAAGGAACATGGTCAGTCTCCAGTTCAGCTTCTGGCACCAGAGTGGAACCCAGTAAGCACCATCAGGAATGAATTTCACTACAACTGTGGACAACTCTGATTTTCAAGGGAGTAGTTAACTTGCAAATTACATCCTTGCTGAATTCAGGAGGTCTAAAACCCTACTCTACCATGTTAGAAAACAGCCCAGGATTTTCTCATTGCTCTGCCATCATATATATCTATGACTAGAGCCCTCATTTTTCCATCTGCAAAACATAATGCCTATGTGTATTTGCATATAGATTTGAAATCTTCATTCAAGGTTCGGTAGGATCAGATTTTCTCAAAATAAGATAAATAAGGTTCAT + 31046%;945+6329=<57//?;599<9-:<1:9<=4;;-6<>38<:858>47+<4778792;9>=;=::;65+=;9:8;63?;359'5,3%+7)59;<=93:?7<836868:>8=4+8;6:88)636>?>:<8:069;;<2;26:94:>=:6.$*:;177,68)<8979<<(;>=,3232;966(:3*3;:7+.494701;127=;903<99.8./244%.48#79-5==675291>:7<=?;256903;2:=745;3=9:94?=/82;9<,:49>.>;7,7;<2=>;;19561743483-<:,49-,;=4=<6:;99375:2'3,325=8??:4+0><38?4<6;>:;>=;;==;::'07078<9:2643&)9-.:3<7:9<43:6>5329;7%9971<241620*625,6786/67664<3>9<0:$49:/%,**-3.08.7743716243448%-426;824$-5),25/76667778983:5.35+3535/+6547546,-45/::80157::5:2887,2304433&7/948&127.331,%3955::7648865&2.6-43'+-/6+6;:841367-60079537,39555(5555$+78-::47'384691%38580/6%.484110'0356'7/,--1536:6655&2/14+,)8868,231764'935814&3.40027,850653166/666664-56844.:4048/58:1100#(6%06-,4499.9-4653+9:591737-04507$/3777&1/,196/5923554,4141/5;7.547436*74089414+(&/023*40++81242.58076842'/-14$04124-65.76843-9528945560499/8*:643(7/*+-343$'7*777520'759997'-4*268*032/53655300,5+85-8767271476$628787052-898.4:7651-3768155&*1(2:56,60*.41,/5(863826763/,7,5:7:;847217676436/540:998554319/3/6769.573880667*+6;59:95843(44-'39522)77599398,0.&438/3,625:2-50666:75:346;38&7/9,5960;6385;;9:85*:56448976.2#)3+65-5.749.4:::7797558:99228'50236;5403979:51/5+*69656/6.63467442-3117872741.-&,491324:7:.7/354041(33*2+,65656545::936499,/.+.'14-99954:7414)-29;488/5:77/,37+6572:9815-+26.74:90#234848:55744.3294:30475.49:986*589443/40/03.5206-9:7246/6.676*14+--2(027;3,&046446233516/36:0:63(91505&(38:4/%4.+4435170,44558:;597176.47*:1::9716::567,097.3)---.025)531490072345(42.9.6964':49922:4628748;51.6:;697&5137370:;6(77466+/(-89727.403)6488852;6.148+64:78454&68-4%19424.,)3+316,352/21/.372*)&(5:98):877645421(%,%/54329151584825-/+4/'-/)52977(97759297:56'88-:880.85958+,.815+066+98869:06:3854632395;73'424 @rCer/206/25_1554_CCS ATGGGGGAAGCTCGGCTGATTCTCGGCTCACGCGGGAGGGGAGTAAAGGGTGGCGTTCCGGGGCTGGAGTTCGGTGGGTGCAGCCTGCTTGCGAGCTGAGGCAGCCAGTGGGGCACCTGCGGACGGAAAAGAAAGGTTGATTACAAACAGGACCATATTTTGCTTCGAAATGGAACCAGCAGTTAGCGAGCCAATGAGAGACCAAGTCGCATGGACTCATTTGACAGAGGACACTCCCAAAGCGAGTGCTGACATAGAAAGGTTAACCAGAATCAGGCCAAGAAATGCACAGTGATCGGGGGCTCTGGATTCCTGGGGCAGCACATGGTGGAGCAGTTGCTGGCAAGAGGATATGCTGTCAATGTATTTGATATCCAGCAAGGGTTTGATAATCCCCAGGTGCAATTCTTTCTGGGTGACCTCTGCAGCCGGCAGGATCTGTACCCAGCTCTGAAAGGTGTAAACACAGTTTTCCACTGTGCATCACCCCCAGCATCCAGTAACAACAAGGAACTCTTTTATAGAGTGAATTACTTTGGCACCAAGAATGTCATTGAAACTTGCAAAGAGGCTGGGGTTCAGAAACTCATTTTAACCAGCAGTGCCAGTGTCATCTTTGAGGGCGTCGATATCAAGAATGGAACTGAAGACCTTCCCTATGCCATGAAACCCATTGACTACTACACAGAGACTAAGATCTTACAGGAGAAGGCAGTCCTGGCGCCAACGATCCTGAGAAGAATTTCTTAACCACAGCCATCCGCCCTCATGGCATTTTCGGCCCAAGGGACCCACAGTTGGTACCCACCCTAATCGAGACAGCCAGAAACGGCAAGATGAAGTTCGTGATTGGAAATGGGAAGAACTTGGTGGACTTCACCTTTGTGGAGAACGTGGTCCATGGACACATCCTGGCTGCAGAGCAACTCTCCCGAGACTTGACACTGGGTGGGAAGGCATTTCACATCACCAATGATGAGCCCATCCCTTTCTGGACATTCCTGTCTCGCATCCTGACAGGCCTCAATTATGAGGCCCCAAGTATCACATCCCGTACTGGGTGGCCTACTACCTGGCCCTCCTGCTGTCCCTGCTGGTGATGGTGGTCAGTCCTGTCATCCAACTGCAGCCCACCTTCACACCCATGCGGGTCGCACTGGCTGGCACATTCCACTACTACAGCTGCGAGAGGGCCAAAAAGGCCATGGGCTACCAGCCACTAGTGACCATGGATGATGCTGTGGAGAGGACCGTGCAGAGCTTTCGCCACCTGCGGAGGGTCAAGTGAGGGACACTGGAGGCTGGGCTCTCTCGACACATTCCCCAGCCAGTCACTCCTTCCCCTGTGGAGTGAAGAAATAACATCCTTCGAATGAGTTTGCTCTGAGCCTGTGACTCCTCCTGCTAGGCAGAGAGCGCACCCTACTACTTCCATGACAACAAAGGCAGTAAAAACAGATATTTCTTCCTTCATGGAATTGGATTTGGATTTCTTGAAGCAGGCAGCTTCATATTATACTGATTGGCTC + KK(KKKJ?KIDKKJKJKKHJKKDI>KIH?>JJH>KJC+KKKH?HBKJEKKKIKKKBK@K'KKKF->KKJKKKCKKJKKIKKKKIKHJKIKKKKKFKKKKJJ#3HDKJBG$KKK9G>KJKKKK>KIK7KKKH6KKAKCKJFKKBKHKC3KKFDJKKKK;KKIJKAK1KDKKKEKKKKKKJJKKKKKKKHJJK8K.KKKKKKIJJKJIKKIIKKKKKKKJCKGJJEJFKK%KJKKKF:GKKEKJKBKJK'KKKKAKEKHKK>BK4KKEDKKJKFKK+KKKJHJKIJDJBKGDKKKK9I9KKKGEKK5JHHKKK>KKCKHKKKIKK>KKKIKCKIKKJKKK2KKKKKKHKKJ7KKKJGKKKKKKKJKJJK2KK5KDEKCKKIKHKKKEK?K0KKKJGIEKKKKCKK5KKEDKKKKKKKJKJKKGK8GIAJFKKEDIIKKKFKKKKKKE5KKAK:KKKHKKKKKKKKKKKKKHKK@KKGKKJFKKKDKKKK)J2KKJKEKKIKEJ8IEH:JKJEKIJKJKJGJK@KKI'KKKKKKIKJFA@HKJBKKKKKK>KEKBKKI/HKKKKKKKFKHKD?KKK@KJH;KCKKKF-IBFBKKHD5KKKKKKGKKKIKKKHKKKKKGKKKKKKEKKKKIK2KKCAKKJHKKJ?JKH8KKKBKK7KDKKKAKKJKKKKII7J*IFJJJKKG(KJJJ:KK0KKKD*KJKKAKDKFKKHKJJKHHJKIKKKKKKJKKC8JIKKKKD89(KKK:KHIHIKKKIE)KKJKKIJKKKJ>KFKKEIJKKKK(K3KKG@HJKKDIG7GACJKHHKIJJ6=JKKKKKKKFIJJKKKKKAKGKKIKKIKBKKJHKEKKJ@82JKKHKG4KKHIJIJKIKKJHJEIEI0?K;KHFKKKKKKKJKJKKKJHD:KK3K2KKKKJKEK?K9KJJJJJKIIBKIDKJKKKE5KHJHKJGJJ@KKJKKJKJKJGKJFKKKKKKKKKK+KJKK.KG>999=1=9.:==/=:7=;<:<68:55-57>?=>=5>>;><=9>><2>>3?9>5299:1:154=;:*88?=9?>>?9?=>=762:==99=>8>?:=9<<6<16;:=2;>=7=4>9?=8=8?4;;=:99395==5:;?29>6583::;<7=0;?:998=?;4>=967>.782=?:<>=82866>?9:,>4=?=<;:567;<=;196-:;2714.4-8=7;99:8:6*;>7296>=0:;<6:5=;0<6>=:>:5=;=>?;<7;:4<>=62:79?><39=2?=6>>3<=??;<:?>;2>;:?><>;<;83793>5;2;==;8,57696>==>>/3>?>17<2>><<8<>:>=<:5=87?;>=9:89><;<=>:<3=>;?>;;<82:<5=5=?<98329>999=3=<>>;=>??4<=764/7<077';77>??=>=;:579>>;;57:6;28=<2>8:99?=>=2;=:82=>>9:=895::2<08?<=88;%98>?88;3==:>>9<=1=>92?2=:<=8:==9:?>36:><;+?8=3<==6:5>>6;;3;9=88<=2:7857??7>9;68=>?;>;:988<-?==647=:6>?>>?99359*:<<&::/<999+565::9;>=<3=:=:===(;:=26<.;=9?9;8:2<1? @rCer/212/2399_59_CCS ATGGGGGAAACGCCAAGCGGAGAGACTCGCCGCCGAGGCGGCCTGAAGGCAGCGAGCAGGACAGCAAGCGAACCACCTGGCCGTGTTTGCAGCCGTCCACCCGCCGGCCCCAGCGTGAGCTCCAGCGTGGCGTCCAGCTGGCGTCCAGCGCCGGCTCCGGCAGCTCCTCCCCACTGCACTGCCCGCGCCCCCCACCGCGCCCTCCCGCTCAGCCCGCTGGCAGCACCGTGGAGGCCGTCCTCGGTTCCGCGTTAGACCACATCTTAGCAATGTGAATATTGCTTCCCTGGAGAAGGATCTGAAGAGCAAGACGGCCACGACCTGGGACCAGCAGTGCCAGGTCGCTGGCCGGCTCTGCGCCTGTTACCATACCCGGCTCCCTGCCCGAGCACCATCGCTGCACTCGCCGTCCTCCGCGTCCACCTCGCACTCAGTTCGCTGTCCCAGCCCTCCCGGGCCGGTGGTTCCTCGGCCATGACGCCTCCCAGCAGCCGCCACCCTGCGTTCAGAGCCGGGTGCACTGGGCTCTTCAGCCTCATCCTTCAGCTCCTTAGTTTGAACGGTGTCCCGGGAGCATCTGGGACTTTGTTTCCGGCAGCTTCTCCCCAGCCCACCCTATCCTGAGCGCGGCCCCCATCCTCTCGGGTTCAAGTCCAATGGACTGAGCTGGCCCGGGTCAGACGGCAGCTGGACGAGCCAAGAGGAAGATCCGGCAGTGGAGGAGTCCTGGCAGCAGGTGAAACAGGTCTGCGATGCTGGCAGCGAGAGGCGCAGGAGGCAAGGAACGTGCCCGCGTGGCGATAGTGACCGCAGCTGGCGCTGCAGAAGAAGGAGGAGGTGGAGGCGCAGGTGAAGCAGCTGCAGGAGGAGCTGGAGGCCTGGGCGTAGCCTCCACACTGCCGGGGCTGCGGGCTGCGCGGACATCGGCACATTCCCTGCCTAAGCTGCACTCGCTGCAGAGTCAGCTGCGCCTAGACCTGGAGGCGTGGATGGCGTGATCTTCAGCTCCGCGCCAAGCAGTGCGTGGCTGCGGGAGCGGGCCCACGGTGCCGTCCTGCGGCCTGCCAGCACCGCGTCCTCTGTGAGCCGTGTGCGGCCGCCGCACCCGAGTGCCCCTACTGCAAGGCCAGCCCTGCGGTGGTGACCTCAGCGGGGACAGCACCTCCTGCTGGGCATCCTGGCTCAGTGCTTGTAACCACAGACACATCGTCACTCACCTCTGTGCCACCGATGTGAGGACCGAGGCTGGGAGCCCCGCCCGCGCTCAGCCGTTATCATGAGGCTGGGAGCCCCGCCTGGGCTCGGCCGGACAGCTTTCCTGTCACACGTTGTCACCTATCTAGTCCTACCGACGGTTTCAAGGTATTTTCCTCAAAAACCTTAAAGGCAAACCCACAGAACCCGCCTGCCTGTCCTCGAGGGCCTGGTGCCTCAGGGTCCGCGTGGCGCTGTGATCACAGCAGTTTGTGGTCCTGACACTCTGTGACTGGACCACTGGGGCTGGGTCTTTCAAAGCACTTTGTAAACCGAGGAATTTAGAGTCATAAATTGCTCTAAGCTGCTTTTTATGTTGTTTTTTAAATATGCGATAATATGAAGCTTATATGTGTACTGTGAACTTAAATATTTCATATCAGTTATTGTCAATTCATAGTATGCTGAATATATTAGATTTCATATTCTGAAACTAGTACTTATGAAATGAGCGTTTATCTAGTAGTAAGACCTAGGATTTTACATTTTCCATTAAGTGCATAGTATTTATAAGCAGAGTGATTATGGATTTAGATGTTTTTAACTCGATGAAGGAGCTTGTTTTCCGAGCCTGTGCGCACAAGGCACTAGGGTTGATATTCCAGCCTCGTGACGTGGGAGCAGGAGAGCTCCGTCCTGCATTTCTGGGATCCGTGGCCACTTTCCTATGTGCCTGTGCCTTGCTAAACAATGAAGGAACATCATTGGTTTTGTTTCTCCTTGAATCTCTGAAGACAGTTTGGTACTAACGAAAATGCAGCAGAAGGATCAGACATCAGAGGTTTTAGAATTACCTTTTTAAGAGCTGTCTTCTGGCCGGGCGCGGTGACTCACGCCTGTGATCCAGCACTTCGGGAGCTGAGGCGGGTGGATCACCTAAGGTCAGGAGTTTGAGACCATCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGGCGCCTGTAGTCCCAGCTACTCGGGGCTGAGGTAGGAGAATCGCTTGAACCCGGAGGCAGAGGTTGCAGTGAGCCAGGATCATGCCACTGCACTCCAGCCTGGTGACAGAGTGATACTCTGGC + EBA9<>%7C7;EGBA:<::1EE@;?;<>B6273344=&593@(A>D:71?5BEFB=ECE?:?9BDF49%5512$<:0=@-76>C@>C.ADAED-C0@=AB?;:&D:CB@A5EE@A>?=?DA;>A==<<<=7+7;-)?<36$/8@$52>CE=D@1?4DE.A:>;7A1;2D=FCAC>@EGA9>>+C7B4>;5G=4B<=$020@B3BA??:?66DG=?@6BEABE>)A3BDA@$<59:@;D37<@E'BD<9=;7*:A>6=B?@@=@=A3B-A)>@5A?8DD<08++>?=68FC?:>;23B=CFG:@>>(;86>=<9?9AF69A=$9AA;?==7BC@1A=BB?39@=&09;':8(6/5:58%2.?.@CF3G>C>96B=E:>@=+1DB5?@<@?8105)==<B@B=8=1BA/A;A>*/>B(6?8?8E;?<%D;:;>0<%-4<24A/A;757;,BF3@?-=3763(7-9?@%=AA6$->='C,?A2>C4-85&-0BA%:12E;=82:'DA'>B&>F@?;=>6A4?>BD>2>A='22;)64@(=+<0??881=8>4A++3(1/6E/*E-24)>>;3?58=3:=C2>A@=@61=8(?B=FFEB?:A>7*8>?A@@D@5),*?(D6DE?ACB(DB6>4)%985<@C9733&676:=71A>3/57'/5;BBAC;?=64=7;:1BA3;A?CD:AEB4@AA96=5;8@/4C/>563B=>A28,?D7;A982:<+:@5<<;=*7B>>CG>;AAF?@:C?1%?CEBGA@>47)<-=B><:D@?>90&2/$.90=@D2ACC?;:=)=BG3C?F==='>EB24?4;B.A4@7B?998=9<11B/?BDBA@A7:?<'9194;??C(;?E>F?;<<'.2<:<8)12<=58@9@C?FFA@ADD6:5;>),@0CC/?C2=BD+EF?CBDC>;3$4?CE<72@:C2@+;B3A663:7CFC;A;=:72>4301=AC4@F0?9?3:?BE7:>DD?0>-5:@=4B:ED@-EGAEF@3:6;C-9'D=>=>E=DC0=453C?@B=7;A=FCEBGB=;D9@DCCC3@><:-.@6+1;A-=<9589:87@>&82A<>:91';@:@B%3;29>9@?>A@@6BC5@;@=CD>@;@DD><%1>=?:12E9?F:@80:=;'52;=2?5BGEG:>.CAA+B.C@2>;4$;@@@>C.=0D@@<:?69<=A?=6:;3=6@E3C;:C?>*8<+=97=>;81.%3(8'5':54'@DAECECC?B868,D88>1DC:919A2==:C@<6;?%9=>8;::B>-AEEB<+><:;>@CFDDBA7?4;F@/337A@E9<=?><47-=A=9834+??A?:98:?-A7:58$>0A=?<7??9A<7-@+:744.5BB:<599B@<9;998:63%/86-4+7867974;=07(6870;<*>===4=>?:;:?6>015;7$+2::8=83=39=:6;(;9<1+9<4;8#3;=76*;*52=;763?:96**566&277(;:>;4862:<88$16;-:98'7.72335/3677:&79>=><=;7)9$9<=<4532>5959:0:=;,8;:37+/:0;;63'9,+;:8=:>;;:;:,98;&7>9==;<*7:780:3>;876$6::75&<<9*5=9:*07>4;:6:2<>87+92390849<<32.$747:29.437:'19;4*45%9>30322869989:.;=>>=5:.?>;:?638$8,/>456)68$9964:73838<=,4;<,962;;8:*502<9.48:239=,;9>8;.;>8<+<=7;;1;?99):>0<=<44=6:;>27;2=:0/177(6:6399(2:663 @rCer/215/0_681_CCS CCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAAAAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAATACAACATCCTGGAAGGGTTGGAAAAACTCAAACATCTAGACTTTCTGAAGCAGCCGCTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCACAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCGCAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAACAGTGAAAAAAGACAAGCCAGTAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAGGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCCGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGCAAAGCCTGAAGACAAGAAAGAGGAGAAGGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAGAAGTCAAAAAAGAAAT + S#&/1(0//6465.3-54065+111/++777:5::0653.'+.95/+5+25.24.=646<.=%3358=639<8>C>@871BAA.@>6@9%>./8:6<1#7@@7@83116??:BA:.60=;8=%94;-?BB=@-@2;A?>>;39<777;:<:;321:>7.4.6/8<;-66<97731/9;==:>7>=:62.9B==67-8;>=97?>0?852=:<3@=<<881=>=;59/:=;6:?:<=<<:06*89:99:5;97:><;9<4C<::>1@===?8?4@BB5>>AB?:95A@53)9:.=>1@BBBAA?BBB==5B>=@?B;;<@?A2=?,8A?<2>49.>31<4==?C;?2#>><::30A93AC.>88B,:>;@=8=0?8@B88:*?@@8@A37?C0/9<<>B@>@7C4C3C744??6?=>@?99@=?>A@>A@=;A8<81?.A=-?=<@?BACABC5@7:97:BA;A:C=A7?=?B<>9<>@9CA;>>9CCA5:34=A@8A9C@2B@;05B685>AC3CAA<>C4CC069A@9775:BAA7?BA>7=69B47%8@;43;8?A@@.A=B@>AA2C6ACCC8B.BA=A?+<6?C4A>@:(DD?A@9>78B*@ADA;8.5DC @rCer/216/24_1932_CCS ATGGGAGGAAGGGAGGCGGCGGCGCGAGGAGGAGGGAGCGGCCGCGGAGCCCAATCGCTCGCTCCCCTTCCCGGGTCCGCGCGCGGCGCCGCCTCCGCCATTGCTGCGAGCAGGAGCAGGCGACGCGGAGCTCGGTGCGCGGAGCTCCGAACGCTGAGCTGACCTGCCGGAGCCGGGCGTGGCTGCAGCCTCGGAGCTCCCGGAACGATGGTGAAGTTGGGGAACAATTTCGCGGAGAAGGGCACCAAGCAGCCGCTGCTGGAGGATGGCTTCGACACCATTCCCCTGATGACGCCCCTCGATGTCAATCAGCTGCAGTTCCCGCCCCCGGATAAGGTGGTCGTGAAAACCAAGACCGAGTATGAACCTGACCGCAAGAAAGGGAAAGCACGTCCTCCCCAGATTGCTGAGTTCACCGTCAGCATCACGGAGGGTGTCACCGAGAGGTTTAAGGTCTCTGTGCTGGTCCTCTTCGCCCTGCCTTCCTCACCTGCGTCGTCTTCCTGGTCGTCTACAAGGTGTACAAATATGATCGCGCCTGCCCGATGGCTTCGTCCTCAAGAACACCCAGTGCATCCCAGAAGGCTTGGAGAGCTACTACGCAGAGCAAGACTCCAGTGCCCGGGAGAAATTTTACACAGTCATAAACCACTACACCTGGCCAAGCAGAGCATCACGCGCTCTGTATCGCCCTGGATGTCAGTTCTGTCAGAAGAGAAGCTGTCTGAGCAGGAGACTGAAGCGGCTGAGAAGTCAGCTTAGCGGGATGGGCAAGTTCCTTACAATGTGTCACTTGCAAGTAACAAAGGGACTTGAGGGACATTTCATTAAATATAATTACTGATTCTTTAGAGGTTACTCATTTATGGTGCAATTGCTTCTGTTTGCTAATGCTGCTTTGCAAATAAAACTTGCTGCCGACCACCCACGGGCATAAAATCAAGTGCATTTCAGCATTGCCTAAAGCTCTGACACCACTTTTCATGTTAAGATCTTCATTTAGCTCCTTTACTGGATTTATTGGATGCTGTCAAAAAATAAATTTACACTGGATATGCCAAGGGTTTGGACCTCAGATAAATGCATTTTGTGGAATTGATTTCTTGAAACCACCCTACTGTCTGCAAACCTTCCTCCATAGCCATATCTAGAGTGATCTCTCGCTGTGCTAAGAGCAAGCCTCCTTCGCATTTCTTCCACTGCCATCAGCAGGTAACTGTGCTGATGCTGCCAAGATGCACTGTAGTGAGTGGCATAGAGAATGAGGACAGAGACCCACCTGCCCCCCGTGCTGAGTCCTGAGTCGGGGTGGGACGGCCCTGCAATGTGGCAGGCTCGGTGTGGGTTTACTACTCTCTCCCCTCTGACTCTGGCATCTTGATAAGGAGGGAGGGGCACCACCCACCTGGGTGGCGACAGCTGGGGTTCGCTCCAGTGTGTGTAGACTGGCAGAGCATGTGAGGGAGGGGCTGGGAAGAGATGGGCCTGGGCCGGTGAGGCGCAGAACTCTCTCCCTGCAGGTGGTCTGTCTGCTCTGGGACGAGCTGATGGGAAAGAACGCCCACCGGCCCTCTCGTTCACTTCTGTTATGAACACATTTGCACCAATAGCCCTGTTAGTTTTAAAGAAATGAGCTGGGTGGGAAAAGTGGAAAATGTAATTTCTATTAAGCTAGGGCTACTTTAATTTTTATTCTATGAAACTGATATCCTTGATGTGGGAAACAGGCAGGAAAGGCTGTGGGGTGGGGGGCTGGTGTGGCACCGTGCAAACAAAATGACAAATTTCAACTCACGATCTTTGTAAGAAAATTGTTCCAGTTTGAATCTTGATATTAAAGTTTATGTTTACAAGATTGCCAGTTAGATGAACTAAGTGTGTAAAACAATTAAATAGAAAAAAGACATT + 4*(2--%-36156/)14125263625-46/034(12,0604/644.246456,2/445.1425/56531464)322-0134531010434//42465565061./15//001*02361022+/531050-.23343,040*133.//11(2424664113511214-6,44/04,241-1$3/4263(/32/.4544)*551515/2104545-3*+2%*,-46226+32.14+05-03)05522436/4.)06235414**%(543.5.14610,'/1,25-6641440-15.'132.4554566166354653505354652)30,1/5201646-23411,2%112/2*244122240,2003,.2044645263436,453664300.1152%021221-3364365*4144632.255022345642353463/3414/555152)0/6514..4445.*0-+50*0555.621$,5-223144000213*2,20/3-6413356534,.33-415452,52.2*.*/2452-555+5+44-/3306554-1/1$/.24-316565214/4,440236.653622-460443),105,4,/15265343,64+4.-55+4455156)2/41002/0*/'./3545551-,$)*246/5/66440+41-0.1642511544153440140//-1135/0-4544352/,24.5450.(,+-040332+/1+4610144426526240264100/15102*51-('-23*3413'/01-41124444*454344/5./)1--6636660#.//36645.(0341.6.4405452266441.,20,52014/60235215+250+.5531/3140/,03/1(43-4434.34.43153130231*0/0-%*0144(/,)-.1/.322)55302)-//,7459:447/598.2580963:8,5&+$554/535251+386582656:8;659,/911.163:5889.999:6$3266769;9;74888::2$6:9984389+992848:7;67:53363;,86-::698:99:930357:7555'6335:7:9;7;::6978,993999:5447087885512428878:;6;4:;:5997784+79/-388.8631530/86::0848:972::260/:79:.78498288.174:59.4+838:6677697/:99:818896%17..,53989:6::7::566.2,0,598,*52798;768487:49655/:673628*6794857655/'445968957619794(8779(505556919896778135.487;566,9436766463/30,3,-84:7:94374557577328/7/69-334;74)859985:52986.881:41/7:6::36587;;6+8899.7;827:6:7642948:4;8.9885956261/7656:;:556;886579:3498999478174:468.:9:7767;672655'1169/53;78;:76107879/9789878:9:3-44048700636;52,779:;9;-84864144786::;:57-8676894-885;957:696:744/::8:751/$6542787&8842055:7;;739:66;99)36%21/266437;;15-296;:8580399868+8727/9:8:54848731+351375563$1495827/5;;49;::4855(59;;57/&/7264411:9698735748(0982694/376;98+8865676463*3551:,7463467:.52:4-667:?<5<2)0477817;5;:174?9::<::7<45.860883:0855616+;<4;63(84=5;:.856*417=6::-9=45-55:-84145%799:70/675< @rCer/219/2249_56_CCS ATGGGGGGTAATGTTTTGGCCGCTTCAAGATGGCGGTGCAGGAGTCGGCGGCTCAGTTGTCCATGACCCTGAAGGTCCAGGAGTACCCGACCCTCAAGGTGCCCTACGAGACACTGAACAAACGCTTTCGCGCCGCTCAGAAAAACATTGACCGGGAGACGAGCCACGTCACCATGGTGGTGGCCGAGCTGGAGAAGACACTAAGCGGCTGCCCCGCCGTGGACTCCGTGGTCAGCCTGCTGGACGGCGTGGTGGAGAAGCTCAGCGTCCTCAAGAGGAAGGCGGTGGAGTCCATCCAGGCCGAGGACGAGAGCGCCAAGCTGTGCAAGCGCCGGATCGAGCACCTCAAAGAGCACAGCAGCGACCAGCCCGCGGCGGCCAGCGTGTGGAAGAGGAAGCGCATGGACCGCATGATGGTGGAGCACCTGCTGCGCTGCGGCTACTACAACACGGCCGTCAAGCTGGCACGCCAGAGCGGCATCGAGGACCTAGTGAATATTGAGATGTTCCTGACGGCCAAGAGGTGGAGGAGTCCCTGGAGAGGCGTGAGACGGCCACCTGCCTGGCCTGGTGCCATGACAACAAGTCCCGGCTGCGGAAGATGAAGAGCTGCCTGGAGTTCAGCCTCAGAATCCAGGAGTTCATTGAACTCATCCGGCAGAATAAGAGACTGGACGCCGTGAGACACGCGAGAAAGCACTTCAGCCAAGCAGAAGGGAGCCAGCTGGACGAGGTGCGCCAGGCCATGGGCATGCTGGCCTTCCCGCCCGACACGCACATCTCCCCGTACAAGGACCTCCTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACAACTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCACAGTGCTACAAAGAGGACGGCAGCTCCAAGAGCCCGACTGCCCCGTGTGCAGCCGCTCCCTGAACAAGCTGGCGCAGCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGATCTCCGGCGACGTGATGAACGAGAACAACCCGCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTTTGCCCAAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTATACATCATGTAGGCCCCACGTCGCCAAGCGCACGCCTCGGGGACGGGCTGCAGCGGGCGGGGAGGCCGCGCCTTCCTCCTGCCTCGCGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGACCAAAGATGAGTGAGCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACAGCATTTTGATTGGTAGGATTTTGTAACACGTCAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTTCGAAGGAAACTTTTCTTTAAAGACTGACCTAAACACTGAGGGAAACTTTAGAACGTTTAAAATATAGGAGTCCATGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAACGGGCTGGTCCTTCACCACCTCCCGTTGGCCCTGGCCCGGCCGGGAAGGTGGCAGTGGCACTGGACTGACCTGCAGTGACCCGCGATGCCGCGCCACAAGGGACACTCACGGCTTCATTCGAGAGCTGCTGCCAAAATGCTGGCGCCGCCACCGTCAGGGGCTGGCTTCGAGGACGCCCGCTGCCTCGCGGGCCGTGTCCGCGGACTGTGTTCGTACGTGCGTAGTTTCGATACTACATTGCGGGGCTGTGTTCCTACGTGCGTAGTTTCGATATCACACCCTCCGTGTGCCGCCTTACTTCCTGCTTTGAGAATGTATAACGTGGAAATCCACGGGACCAAGTTTCTGCAGAGGCCTTGCCGGATGGTTCCATAACTGTAGAGTCTAAATACTATCCATTACAGAAATTAATCGTTCAGTTGAGAGAAGTACTGATGACTTTTCAAAACAAATGAACCATCGTAGTTGACAGAGAACCATATTGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGACTAGCTAATAAACTGTAAATGTAAACCATGCGAATAAAATGGTTTTCTATTTCTCATTTCTGTGT 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A?DD=59)0@75BB?D.B4GFGFF?DB7BAAGBFE>>@=>>0=?FGECEB>;CCBEE8DBF;79A@CB;>FB3D2AFBFB>BD@BFA;:CFCDF/BAAFE3@@3?DDDCBC*D@C1?71(??2;ADE;4>?=EFFD:=CCFDD<7::?;=A??=5>&DG?B><8@DA;=?CB?@69?>=8<7:;9D6>@:>?F@BAA?DD?6<;B<;?<07>?A;C=>ABCB=GE@CA@@>96;C2D?G>>>A9E?FGDB;E@D;@G?ABC>DD@D6FBFC@@D@BBEGD@>BEE@??5D@DC@=-B>?B;=BFGECBFEEB9=,@::3C?A;;-B:=C?;A3A>@65<=:??>;C09:=9EB3:C@?=CAG=EGA;=?<69ACEEA?=EAE8CGFCDCB@B9B;;<<;->+?A@=@@A@B91=??ECGAED1@BE7FFG8?D@BECBCCB2<7;:C=FC=>?:8C9E>>E>ECE>@F>@B@EA;;;==C@=?@D0DA@8DDEE>@F@F;@<=9<8=9:@8D@CC8?>@A64B>;D?8=@.FCA:9@FDCB<:A??9=:8=:0:81310+6@9>>8/@@A><7?CAA?>9?FA<8:'>?)61':@7+CB?888>@BA8DGC7>:EFF>>2>D:?BBEB564==?BA<6?@<82'?9>;GCA@@@@=9<7<;=@9#=<4<7<:;*>?8975?<95<@A?3(3@E@DGCE;:A9CC<>EEE(9DDE2FAC0BA9@A9A>==784=A@?>CAC6?A?>5132<798::-08'@44>C@;?B@A=<=ABC9@88>@A<<;97<9;4::<;85;0<8<78;290:'98<=:.4.<:57=>>=9>@AAAB?@@B<599>;88@7;-2<:.868;:;6798,63461:3669:66+*1272$.1+3300294556/+*0/0++,4734302-/2.,7;:4<:717499&<;BA866:9BA;6;.AB<8261(6.1779:4=?A==@46=?;@C@??9=;:?>=<<8907B:B6BB6A=@?4AB;-?<=A96::><)4;9:;;<>3<=B9C=A<606;74*7+802>:75/36:084699;?:@@<9)A???;66>?:BBAB>5<=;;A><*;?<:=@:->@A=88.5:=8@7A;7<@;+99<9731<@?8B==8*67718825*1':9::78=59>2B?28?67=:=':,7AA=BB;286@5=/1ABB>=;40;;:<9C=C==AB7@<@7?=C<@<@A8>?A9@@:9?C5@??AA=;CA7/=@&?>=<:6.<2:;A;;2:>C=>69B<>-<9?=9;8;A>9<8;8>B<>B1?:?=A>6:?5=CB<8A6??97;%<<)>A>B@=:?B8=@:8647;4?1@=>5/;3??@?.6;57/1-$:9B7ACCBBA-C7A;BA79732';::?@8>/>;:<-113,?,@A@@85>A7649=?;A8=9B:679:=<350/'0<8?>:69>B<;6+6;:>=;@-9=<>2=99@:<5>A5@2<934;8:;?>2>@490>B@3?>:8093A::+A8?C;A=B5?9B=>2?B?>>:=9*9*?982:B:@A?BB9?2@C7;475<;8@9A=@?>;.?B94;>45064:@68:35:><9??;9+=<:5-:27-;>;6@=ABA>?7;C<729@>AAA?=;33;=?B<>A=B<=?2473>>6=>5=5.7==?<>8?06>@?2<;:::99:9<8=:8<:36728:88=919:;?>78):8=>77<::=>1<9<<>:.702;=5;08;98466:89, @rCer/221/0_577_CCS GAAGATGTTAGTGTTAACAAATTGATGTTTGTTTTCTGTTGATTTTAACAGAGAAATAAAAGGGTAATAGCTCCTTTTTTCTTTCTTTTTTTTTCATTTCAATTTGCTGCCAGTGTTTTCAATGATGGACAACAGGAGGATATGCTGTAGAGTGTTTTATTGCCTAGTTGACAAAGCTGCTTTTGAATGCTGGTGGTTCTATTCCTTTGACACTACGCACTTTTATAATACGTGTTAATGCTATATGACAAAATGCTCTGATTCCTAGTGCCAAAGGTTCAATTCAGTGTATATAACTGAACACACTCATCCATTTGTGCTCCTTTTTTTTTTTTTTTTTTTTTTAAATGGTGCTTAAAGTAAAGAGCCATCCTTTGCAAGTCATCCATGTTGTTACTTAGGCATTTTATCTTTGCTCAAATTGTTGAAGAATGGTGGCTTGTTTCATGGTTTTTGTATTTGTGTCTAATGCACGTTTTAACATGATAGACCGCAATGCATTGTGTAGCTAGTTTTCTGGAAAAGTCAATCTTTTAGGAATTGTTTTTCAGATCTTCAATAAATTTTTTCTTTAAAT + S*00+,101*$./'#$)%%(--60001(690+05-.-)%412#676$32844.$0.&%/4/&)/-4239/*65;0955122)02.//47512022'2543$4.67.015-6*/14)/21,+075-12;632.4&/1,(33./(6842--)-.*.((13-(461848,097+*+31/.693%32-/+486(4390)7.9623+22:/:63030(/,656:6245:2/4733&31(05'.35,-)-1,*./&,/-,.8211:>16276283617*10-8/;3)<-785-871-.()+6/2228005718753,71.8<70;=<=8%;38::896633889:==:72-(2*/.700747)5437-26.16',,-,/%63./2731-,''+*03)26*,2()&-+,.,*43*#%)&.1-295-38+89-3*)+.'661/1*31.84/370-42-138>:86*,14<:27965167925.-395)265606529.%,773><>62;89133625<97,4;9132.*+101--+9/8)=;6645+4/0'%0,36774*2:5.2676(2)%:57;03.1;'412 @rCer/222/2022_88_CCS ATGGGGGGGGTGACGCGGGCTGGGGCGCGACGGTCTCGGCAGCGGCTGCAGAGGGAGCGCAGCGCAGGGCCACCATGGGGGCCCAGCTGAGCACGTTGGGCCATGTGGTGCTCTCCCCAGTCTGGTTCCTATACAGTCTGCTCATGAAGCTGTTCCGGCGCTCCACACCAGCCATCACCCTCGAGAGTCCGGACATCAAGTACTCGCTGCGGCTCATCGACCGGGAGATCATCAGCCATGACACCCGGCGCTTCCGCTTTGCCCTGCCGTCACCTGAGCATATCCTGGGCCTGCCTGTCGGCCAGCACATCTACCTCTCGGCTCGAATTGACGGAAACCTGGTCATCCGGCCCTATACACCTGTCTCCAGTGATGATGACAAGGGCTTCGTGGACCTGGTCATCAAGGTTTACTTCAAGGACACTCATCCCAAGTTTCCCGCCGGAGGCAAGATGTCTCAGTACCTGGAAAGCATGCAGATTGGAGACACCATTGAGTTCCGGGGCCCCAACGGGCTGCTGGTCTACCAGGGCAAAGGGAAGTTCGCCATCCGGCCTGACAAAAAGTCCAACCCCGTCATCAAGACAGTGAAGTCTGTGGGCATGATCGCGGGAGGGACAGGCATCACTCCGATGCTGCAGGTGATCCGTGCTATCATGAAGGACCCTGACGACCACACCGTGTGCCACCTGCTCTTTGCCAACCAGACCGAGAAGGACATCCTGCTGCGACCTGAGCTAGAGGAACTCAGGAATGAACATTCTGCGCGCTTCAAGCTCTGGTACACGCTGGACAGAGCCCCTGAAGCCTGGGACTACAGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGACCACCTTCCGCCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATCCAGTATGCCTGCCTGCCCAACCTGGACCGCGTGGGCCACCCCAAGGAGCGCTGCTTCGCCTTCTGAGGGCTGGGCATGGCCACACGGCCACCCACCTCGCACACCCCATGCCCTGTCCACACTCACCCAGTCACCTCCCCACATTGCACACTGGGGCCCCGGGTTCAGCCTGGCCTGCCCGTGCCCTGGTGAATCACCCAGCCGAGCAGGCCCCCTGGGGCCCCTTCAGGAGCAGGGCTGTGTCCCAGGTGGGTCACTGCTGAGCCTTCAGGGTAGGCCCTGCCTGGCACTTACTGGTCCTTACCAGAGACGCCCAGTCCCATCCCTGTCCTCATGACCCCTCGTCCACCCCACACACACACTACAAGGCTGAGGGCTGCCAGCAGCCATCTGCCCACCCTTCCCGGCCGTGGACCACAGTCAGGATGTCAGCAGACACAGACGGGCAGCCCAGAGCTGCGGGAGCCAGGGCCCACCCCAGCCTCACCTGGCACCCCCACTCCCGCCTCAGGGCCAGGCCCAGGCCTCACCACCTGACACTGTGTGAGACATTGACACCAGAAAGCCCTCTTGGGGCACTGCTCCCCGCCCCAGGGCCCTGGTCAGCCGGGAGTTTGGCTCTCCTCTGGCTAGAGTGGGAAGAGGGAGCTGGCCACGGGGCCCTCCCAGCACCTCAGCATTTCCTTCCAATCCATCCAAACACTGAGGCAGCCTCGGGGAACCCCGAGCTGTGGGGTCGGCAGCCCGCTGCACCATCTCAGGGTTTTGGGGTCCTGGGCTGGGGCCACCATCCCTGATGGCAGAAGTCCCACAACCACATGTATTTATTCCTCTGTCCTAAACCGTCCCCTCCTGCCCTCACCCCCAGCACAGGGGGATTCTGAGCAGTGCCTCTCGTCTGAGGGACATATCGGTGACCTCGACGTTGCCTTTAGACTACAGTTGCATTAGCCTCTGGCGTATCGGCTTTTTCAGAGTCATTTATGAGCAGAAAAAAAAAAAGTAAAACTTTGCTAATAT + KKKKKKKKK(KKKKKKKKFKKKKK'KKKKKKKKGKKKKDKHKKKKKKKKKKIKK@KKKKKKKKKKKKK@KKKKKKKKKKK6KKIKKKGKGHKJKKKKKKIKIKHKJKKKKKIKHKKKFKKKKKKKKKKEJJJKKKKJKKKJKJKKKK?KKGKKDKKKJKKKKKKKKKKKFKKKKKKKKKIKKKKKKKKKKKKKKKEJKIKJKKKKKKKKKKKKKKKKKKKKJKK2DIKKKKKJKKKJKKIKKKKKJKJJKKKKKIKKKK/JKK7KKKHJKKKKHJKIKKKJKKKKKKKKKKJKKKJIFKKDKKKKKKKIIKKKKKKKJKKKKKKKKKKKKKKKJKKKKJKKKKKKJKKKJKKIKJHKKKKKKKKKKKKKKKCKHKJKKKKKKKKKKKKKKKKKKJKKKKKKGKJKKKKKKJKKBKKKKKKKKJJJKKKKKJKKKKKKKJKKJK=KKKKKKKKJKKIKJJJKFKJHKKIKKKJKHKKKKIJKJ8IJKEKKKKKGKKJFKKKCKKKKK=KKKJKKJKKIKKEKKKKKKJKJCIKKKJKKAGKKKDKDJICJJGKKKKKKHJJIKKKJFKKKIKKJKKKGKJKIFKKKK=KK;KKK:KKKDKJDKHIKKKKKKIKHKKKIKK@IKKIKKJKKKJJKKKKHIJFKKKKK?KFKKKFKKJKIKKJKK>KKKHIKKKK=KKJKKFKK6KKHKKKKKKKKIKJK@JKJKKKJKJKKKKKJKKKKJIJKKKKKKKKKKKKKKHKKKKKJKKKKKIKKKKJKKKKKKKKKKKKKKKKJKK@KKKK:HJKKFJKKFKKKKEEJKKIKKKJKKKK=JKKJJJJJKKJC>KJKKKKKKKKKKKKKK+JKKKKDKKJ3IJJKJKJK @rCer/223/1925_56_CCS ATGGGGACCCTGAAGGTGCTCACCTTCCTCGTGCTCTTCATCTTCCTCACCTCCTTCTTCCTGAACTACTCCCACACCATGGTGACCACCACCTGGTTCCCCAAGCAGATGGTCCTGGAGCTCTCCGAGAACCTGAAGAGGCTGATCAAGCACAGGCCCTGCACCTGCACCCACTGCATCGGGCAGCGCAAGCTCTCGGTCTGGTTCGACGAGAGGTTTCAACCAGACTGTGCAGCCGCTGCTGACTGCCCAAAATGCACTCTTGGAGGACGACACCTACCGATGGTGGCTGAGGCTCCAGCGGGAGAAGAAGCCCAATAACTTGAACGACACCATCAAGGAGCTGTTCAGAGTGGTGCCTGGGAATGTGGACCCCATGCTGGAGAAAGAGGTCGGTGGGCTGCCGGCGCTGTGCCGTTGTGGGCAACTCAGGCAACCTGAGGGAGTCTTCTATGGGCCTGAGATAGACAGGCACGACTTTGTGCTCCGGATGAACAAGGCGCCCACGGTAGGGTTTGAGGCTGATGTTGGGACGAAGACCACCCACCATCTGGTGTACCCTGAGAGCTTCCGGGAGCTGGGAGATAATGTCAGCATGATCCTGGTGCCCTTCAAGACCATCGACTTGGAGTGGGTGGTGAGCGCCACCACCACGGGCACCATTTCCCACACTTATGTCCGGTTCCTGCAAAGATCAGAGTGAAACAGGATAAGATCCTGATCTACCACCCAGCCTTCATCAAGTATGTGTTTGACAACTGGCTGCAAGGGCACGGGCGGTACCCATCTACCGGCATCCTCTCGGTCATCTTCTCAATGCATGTCTGCGATGAGGTGGACCTGTACGGCTTCGGGGCAGACAGCAAAGGGAACTGGCACCACTACTGGGAAAACAACCCGTCCGCGGGGCTTTTCGCAAGACAGGGGTGCACGATGCAGACTTCGAGTCTAACGTGACGGCCACCTTGGCCTCCATCAATAAAATCCGGATCTTCAAGGGGAGATGACGCAGTGAAGGGTGGAGGATGGACGCACTGTCACACCTCTGTGTTTTCCAGCCCCAGCATCTTGCCGGAGCCGTTCCATCCCGGAGCTTGGAGGGGCAGCCTCAGGTGTGTGCCCAGGCACCGCTCACAGCCTCTTGCACCAGCCATTGGCAGCATCTATTCAGCAAGGTCACTAAGCTCTGCCAGAGTGGCAGAGCATGTCTCGGAACCTGTCTTGAGTGGGGACAGCGTCCCCCACCGCTGCCCAGAGCTGGGGAGGCGCTGGGAAAGGTTCAACCTCCACACACTACAATCATTGTAGCTCCCGGAGCGAGCTTGGGGAACGAATGTGGAAGACGCCTATATTCTGAGGGACAGGACAGTTTCCCAGGAAGATGGGCAGAGACTTGAGTGGCGATTCTGTCTAGCACAGAGACATGCCAGGCGCTGTTGGCACCCGGGGCAAGATGCTGCCCTTCTTTGCACGAAGCCCGGCCTCTCGCTTGGCGTGACAACCCTGTCATCTCTTCTCCCAAAACTCATTTATGAGCCACCAGAGGCTCCTACCCCAAAGATTTTCACAGAAACTGGAGGCCAGGTGCCGTGGCTCACACCTATAATCCCAACACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGTCTGAGCAACATAGTGAGACTCCTGTCTCTACAAAAATTAAAGATTTAAAAAAATTAGCCAGGCATGGTGGCACACACTTGTAGCCCCAGCTACTAGGGAGGCTGAGGAGGGAAGATCTCTTGTGCCCAGAAGTTTGAGGCTGCAGTGAACTGTGATTACACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTCTC + 33@;<-5<8/<=>9;86:?::@;4;1=8048=:/*560;<6;?:7-36:83;<6+',643.;66365>74<:4==8=43(59946:*99,8;1$/34+997(7-8B;;>888/?<;?;2?0:@=A287=@?=<0=56?@?BA.;=2:6>B>?=9?18:80:50465+759<=51+6;?78=?-99.424+5C<=.@75>=3:B2=?F>:>CD9:96-06<<10>8B4A:<7;1?:;>=996=A87;'0:=>;643@6:6>??=9>;58?38=966257*4;4>A4>8;.4?>9:318>>=>>4<604A5;>4>C2<>>/A<<>6C@@9::)<7*8;=4=?98(:4?59@?.1@<(7?=<.C7=76<;78=:5>6?68-:3=3::'@0=>6=>7<@;;237(7/:?,6,@:<<<;8*=64;+3;37*:6<27=>>1>;>7,<=76;40?5B987+9;@.05@A46;555<68/335;3-=>-:?5=-89>69>A-:;?<47;<37>>BA@1=@?<3;2=:?87>&=9>8;=.:=:6C84=;5>=:1;1=<939A87;>:3C=:=9<<:6418::=@3:68471;/?@844>;@=A>6:.=;5=?@>9;8>:7?67==0>?;84-3+6-5)>84+:78<96==:48:9@@@4=@>>@78;.;8C<,;>98C>9:5.;8953&7.3;:8=;?=?8;=;3B>=?9@2=7=5>?;4.467-<96:99:9A;B:6=@74346=?*=@;?:><7429'@?AC9=@:5@57B<7A2;;=:8885=;=7:>'AA<8=A;%7=)/>-8)8=A=<>A2%53;>6@>49:3-962.33331/04525*9=C@<*B:39?&A;=79<516<@?>;<:@:640?<<7?B?:4AA9844A1;,<9<1AA:>>;:6?>:>08>@;:2::;(9;-6?;.69;@>9=A>;7;@A2<98A6=<13:3773A=?<=;,228<86)A9377>,;=;@599:@:<57;04872978/&4.3-6:7878376,+0+./*871:>;<66-93/347/2:+32*2/&/:;3>;<899:458677244370;364:/686.242%+2.681-9=99+19;5<9643)39637-//2)477534)1/'/2,44>5=?.>59<-,87<85=95;5<9-8.959799A93714=:6:<698<:9586>1@;7;==253.;;4;.;<7-526;=36.559<=108229=-5:3-1-8/4+889':8;;;9.;2?:;=:29B;:7=7<9<;566=;><2>>=1?64/AA24@=99;?431*/8)2&8C558:>14/40;?9;=79=7;0<8C;49716-:>-A<8;:'8:>><==9;7;8876981829::6=>:4>96::7>261,53>57/:37887:'?::8969;:6>2859$:=467519;9:2766'5::::62=?68><:67496<9<>>35<2+<>>=<120/&-625368573/02#9*16)1605'6489=:1?:=9:87=664,938=63.85;9;95=<:8<68,:385/:2.32-46+4>>>:178;0;:;64;::<8;>:85&:86*7<<,:;>49/6;8473729;=:9090193?73:<7<8932).:118;90,02667/5885:;325:6+576 @rCer/225/2827_53_CCS AAGATGTGACTCGGCGAGGCAGCTGGAGCGTTGGCGCTGCGGGGCCGCAGGGGTCGAATGTTCGTGGCATCAGAGAGAAAGATGAGAGCTCACCAGGTGCTCACCTTCCTCCTGCTCTTTGTGATCACCTCGGTGGCCTCTGAAAACGCCAGCACGTCCCGAGGGTGCGGGCTGGACCTCCTCCCTCAGTACGTGTCCCTGTGCGACCTGGACGCCATCTGGGGCATCGTGGTGGAGGCGGTGCCGGGGCGGCGCCCTGATCACACTGCTCCTGATGCTCATCCTCCTGGTGCGGCTGCCCTTCATCAAGGAGAAGGAGAAGAAGAGCCCCGTGGGCCTCCACTTTCTCTTCCTCCTGGGGACCCTGGGCCTCTTCGGGCTGACATTCGCCTTCATCATCCAGGAGACGAGACCATCTGCTCCGTCCGCCGCTTCCTCTGGGGCGTCCTCTTTGCGCTCTGCTTCTCCTGCCTGCTGAGCCAGGCGTGGCGCGTGCGGAGGCTGGTGCGGGCACGGCACGGGCCCCGCGGGCTGGCAGCTGGTGGGCCTGGCGCTGTGCTTGATGCTGGTACAAGTCATCATCGCTGTGGAGTGGCTGGTGCTCACCGTGCTGCGCGACACGAGGCCGGCCTGCGCCTATGAGCCCATGGACTTTGTGATGGCCTCATCTACGACATGGTACTGCTGGTGGTCACCCTGGGGCTGGCCCTCTTCACTCTGTGCGGCAAGTTCAAGAGGTGAAGCTGAATGGGGCCTTCCTCCTCATCACAGCCTTCCTCTCTGTGCTCATCTGGGTGGCCTGGATGACCATGTACCTCTTCGGCAATGTCAAGCTGCAGCAGGGAGATGCCTGGAACGACCCCACCTTGGCCATCACGTTGGCGGCCAGCGGCTGGGTCTTCGTCATCTTCCACGCCATCCCTGAGATCCACTGCACCCTTCTGCCGCCCTGCAGGAGAACACGCCCAACTACTTCGACACGTCGCAGCCCAGGATGCGGGAGACAGCCTTCGAGGAGGACGTGCAGCTGCCGCGGGCCTATATGGAGAACAAGGCCTTCTCCATGGATGAACACAATGCAGCTCTCCGAACAGCAGGATTTCCCAACGGCAGCTTGGGAAAAAGACCGAGTGGCAGCTTGGGGAAAAGACCAGCGCTCCGTTTAGAAGCAACGTGTATCAGCCAACTGAGATGGCCGTCGTGCTCAACGGTGCACTATCCCAACTGCTCCGCCAAGTCACACAGGAAGACACCTTTGGTGAAAGACTTTAAGTTCCAGAGAATCAGAATCTCTCTTACCGATTTCCCTCCCTGGCTGTGTCTTTCTTGAGGAGAAATCGGTAACAGTAGCCGAACCAGCCGCTCACAGCCAGGAAATTTGGAAATCCTAGCCAAAGGGATTTCGTGTAAATGTGAACACTGACGAACTGAAAAGCTAACACCGACTGCCCGCCCCTCCCCTGCCACACACACAGACACATAATACCAGACCAACCTCAATCCCCGCAAACTAAAGCAAAGCTAATTGCAAATAGTATTAGGCTCACTCGAAAATGTGGCTGGGAAGACTGTTTCATCCTCTGGGGGTAGAACAGAACCAAATTCACAGCTGGTGGGCCAGGCTGGTGTTGGTTGAAGGTGGGGGGCTCCCACTCTGTCACCCCTCCCAGCAAGTGCTGGACCCCAGGTGGCCTCTTGGAGATGACCGTTGCATTGAGGAGGACAAATGGGGACTTTGCCACCGGCTTGCCTGGTGGTTTGCACATTTCAGGGGGTCAAGAGAGTTGAGGTAGTGGGCGGGATTCCAAGGCGAGCCCAACTGAATCGTGGGGTGAGCTTTATAGCCAGTAGAGGTGGAGGACCCTGGCATGTGCCAAAGAAGAGGCCCTCTGGGAGATGAAGTGACCATCACATTTGGAAAGTGATCAACCACTGTTCCTTCTATGGGCTCTTGCTCTAGCATCTATGGCGAGAACACAGGCCCACCCCCTTCCCTTGTAGAGCCATAGAAATATTCTGGCTTGGGCAGCAGTCCTTCTTCCCTTGATCATCTCGCCCTGTTCCTACACTTACGGGTGTTTCTCCAAACCCTTTCCCAATTTTATTCCCTTGTTCATTTCAAGAGCTCCAATGCGGTCACCAGCTGAAAGCACCTCCAGGAGCAGGTTGGAAGGCAGGCACCACGGCAGGCTTTCTGTGATGATGCCACCTAGTAGGCTTCCGGGGTGCCCGCTAGGATGCAGAGATGACCTCCCGCTGCCTTGCAAGCAGTGACACCTCGGGTCCTTTCCGTTGATATGGTGAAAGTTCCCGGGTGGAATGGATCACATGAGGGTTTCTTGTTGCTTTTGGAGGGTATGGGGGATATTTTGTTTTGGTTTTTCTGCAGGTTCCATGAAAACGGCCCTTTTCCAAGCTCATTGTTTCTGTCATGGTTTCCATCTGTCCTGAGCAAGTCATTCCTTTGTTATTTAGCATTTTGAACATCTCGGCCATTCAAAGCCCCATGTTCTCTGCACTGTTTGGCCAGCATAACCTCTAGCATCGATTCAAAGCAAAGAGTTTTAACCTGACGGCATGGAATGTATACATGAGGGTGGGTCCTTCTGCAGATACTCTAATCACTACATTGCTTTTTCTATCAAACTACCCATAAGCCTTTAACCTTTAAAGAAAAATGAAAAAGGTTAGCGTTTGGGGCCGGGGGAGGACTGACCTCTTCATAAGCCAGTACGTCTGAGCTGAGTATGTTTTAATAAACCTTTTGATACTTC + .),0+('00,,.<.%+02&'5>>830:3;:65628;8=;69..*:373.-2/$8;6:4=966<1=>=6;/7=<=5230:5<><;06/>=?=CAA9:585;?0:3..4>=2:>=9791:/98<56@7345689=>=1889706>:467:<;;4:>526604*8<;9,21:?;72146774604;;989:,<===89,2158078,978839678002.40-423.,).).1/3&)'360031#-0542(56//-/*+.1.-,,$08.++15/12346.52'2/<=:70,181=8==9<8094=8>8548=78=<5654755(<9::08167.4=<=4:88<.523=;8567(0:49755+85:;82826)772:8<4297;2?6>;5925:1217.%.1626.3.1.-6./*201)4787387>5707245520479=67:=;-7876<=478?7=>?994679:97==87(6=9>=;9).1//70)4071.941*752+-$-7578.4289.882'5324%:8:==;888858;:33+?<796<65>7&'&:750<868.*13948144:@6;>=9A9<8,/65).6:;;782/<941;2:?793;;754:9(96<,<55289;1:25==3797@)=;A755;605:AAA?;;'/18:8/7?8968+/,'3636@=?::B;9,5.9-7;==.=>107:0>>:7-9==7;6=952&8;.6:/,40)++/.$12//1/340>9;59&?:7566'/+67796*38/5366:396;7942./676+.5(45%8/68230476,21898<932520../10+44.9/7<9;939=>;:52:9677(593<9324422.+1)30008/93035+$*8,=:;154-<6-242:37;92:87631141102-,1)5124-6:698393:;;:6626'81/$1/#)&,+0/+./0803(30.00)%-41/057-8>641591+:99:77*510457554'7/73:5'/971**116(.1532/110-#(/10//0%8246*83+162;48<1:;7:739163)96-;907';=<932<<>;5>;=:48?9466<4736;;.9=<<>>=08<4275::78<<:0:514-/452-82;:<3<;81??=4=:.*6:9>=>?>>;<5.=<<86+01656598;:33287748786::0/127'7204;65100(*$14/.225;2827/26:4'53-77997211:99+;3/711524200&2555387644,0,01)**0(++4355626177176.2024/0'140./.7783193267942585-/:,85/&/432-+23'78(134114/)1.%%$-',)(#23:<99<67=98>;3713896767687+23175:9568754237(/546-0591-*--(1*.-,--301,'167830//,*121;6=27481<8=>9=3879=9>>==6778:0<=;=2=7895;5388;9?:78*0;16:::0=>93534923128'5546;90;3/149>68;:7159&7:4=79<7>9;2;:-=4>=>>>9794386&<1896;=:6<==672<1<<:-7:;2=?>:==:0<9:96+?;=<;+8;9<>89:;9784>>9;5540:580/=;83078=+33;;22;1>?<>8>?::9*16*3:,7:0799=9>::;89:4:1<<>799:9=99>371158:9;0;96&7955064;0398$6?42&.;7839989;=<96/6<2=/214/44/9.)4375114033(223-9?9=686;;809>/9=7<12),,'827=2/36788=97><6=87753=;9>6>7=?9;:3:70:)9795819.3/;4>>>8:9(9.771699683=+6336444.0-.,/+42:54,<;#,/11.#6-:=676492503758665;96664--,,++.*08$13(86'7/%28=?<8-%;+4/:>7&6268=>48880<55445:92=8:8-6999(667496&0629;021.8*9:6563+/4(453:7<==:4:84/65736+)(-/+0(02782,/09472769,3).8.9986%(32/70,(543.75802)4312//63:9990-,/.&(559/455&06-977744%.81528--)9899(3455/--)125.73969:;856:334533-4143626694794768(89:4,18083/675956753.75/231,2/)+,%01('41683-*,4/3.321353-+3.7616524668742/33/-'&))./4)2./556*6133.2459;;36:8953+4,4*--324-%/3./2*528)/-1+,.22,:5797.3../'3,((.3-3+42452&'*+54994586319/1011(450843--0/+536+8415*281+1,12,/-.24))415%/224*4433952723/3'/6:.96:53:7515312895:847:7450049:20967::9-/.21:9083(.4+71:45320,2,4443.5%0*3+4:-96/5678255248439-7493-15066851+(.-)-5.464'471-.&32,*57188)4)5264.;9445989.:57997(41941,79/-+664$()/2.3#9:2498:684-.404.44(2;96357-9:86/823883649:9983.9/11+.1%107&08263627 @rCer/226/2307_58_CCS ATGGGGCAGAAGCGAGTCGGACTGTGCTCGCTGCTCAGCGCCGCACCCGGAGGATGAGGCTCGCGTGGAGCCCTGCTGGCCTGCGCCGTCCTGGGCTGTGTCTGGCTGTCCCGAGAAAAGTGTGAGATGGTGTGCAGTGTCAGAGCATGAGGCCACAAGTGCCAGAGTTCCGCGACCATATGAAAAGCGTCCTTCCATCGATGGTCCCAGTGTTGCATGTGTGAAGAAAGCCTCCACCTCGATTGCATCAGGGCCATTGCGGCAAACGAAGCGGACGCTGTGACACTGGATGCGGTTTGGTGTATGACGCTTACCTGGCTCCAATAACCTGAAGCCTGTGGTGCAGAGTTCTACGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTGAAGAAGGATAGTGACTTCCAGATGAACCAACTTCGAGCAGGAAGTCCTGCCACACGGGCCTGGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAGCACGTAAACCTCTTGAGAAAGCAGTGGCCATTTCTTCTCGGGCAGCTGTGTCCCGTGTGCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACCTTAATCAATACTTCAGCTACTCAGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGATGTGGCCTTTGTGAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGACCAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGTCGGTAGATGAATACAAGGACTGCCACTTGGCCCGGTCCCTTCTCACACCGTCGTGGCCGAAGCGTGGGTGGCAAGGAGGACTTGATCTGGAGCTTCTCAACCAGCCCAGGAACATTTTGGTAAAGACAAATCAAAAGAATTCCAACTATTCAGCTCTCCTCATGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGATTTTTAAAAGTCCCCAAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATATCACTGCCATCCGGAATCTACGGGAAGGCACATGCCAGAAGCCCCAACAGATGAATGCAAGCCTGTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGCGTTAACAGTGCAGGGAAAATAGAGTGTGAATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATCATGAATGGAGAAGCCGATGCTATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCATGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAACACACCCAACCTAATTGTGAGAATACAGCAGAGGAAGGATATTTTGCTGTAGCAGTGGTGAAATCATCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCATACGGCAGTTGGCAGAACTGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAGTAAGATCAACCATTGCAGATTTGATGAATTTTCAGTGAAGGTTGTGCCCTGGGTCTGAGAAGAACTCCAGTCTCTGTAAGCTGTGTATGGGCCAAGCCCAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGGGCTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGAAAAAACCCGATGCATGGGCTAAGAATCTGAAAGAAGAAGACTATGAGTTGCTGTGCCTTGATGGTTCCAGGAAATCTGTGCAGGAGCCTGCAAACTGCCACCTGGCCAGAGCCCGAATCATGCTGTGGTTGCACGGAAAGATAAGGCAGATTGTGTTCAAACGCTGTTACTTGACCAGCAGCACATGTTTGGAAGTAGTGTAACTGACTGCTCGAGCAACTTTGTTTGTTTGAGTCCAAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTCACTAACCTGAGAAATGCTCCACCTCACCACTCCTGGAAGCCTGCACTTTCCATAGAGCTTAAAATCTGAGAGGTGGGGCTGCCACCAAGGTGACGATGGGAGCGCAGATGATCCATGAGTTTGCCCTGGTTTCAGTGGCCCGAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCT + 9:;54*;68<.=>=89<==4><=:859285<:>=?>?4=;;48,168+901?380-<:69>>;$46:-=8663>=>54584>;>:?:<8;+668$7<>:73:=:969=998,;358?=1967=>:>;=11031455<9<979;35>=6338*.(1%2.:<>;8:<=2;%$&75<89,=;;25=>>/9.:9>3?<<904$67--);=764=97>08?768;399?6>>;=:3%3=/61%9;=8?:93<>7:9929+682=:8567=)>;?93<46:;;9:;278<6<;>4>:467$/<*0-9><3;=98>:=8:;79=1777'949?7632;7,=:2:=83/4$7==:88)67254<0;;::=,9985:<=9585065>;4;4=?<==8:>5:34.25;>>?9CA?@7>6A?48;487C?73?<;>7?=>5C=:?AA@;.;891;/<@B4;17&676&:<'949>?/9>C55B;=?A@9+:<%<39178<<&7=4=75840:A3??>8795>+&;=77&<5A;>B=A>@<>-?<31;:07.)4;.8@6>A=@?.:8=><8?==;;&=?B?=<<062>@1?7:.25?@;8;=0=9<;@A<@;7697A687?8<57-?;>;&>AC>?DD:;%E@GA8&4C>??@EGAB@;EG::0AIDGHGFAHFEHEEFDI;DB<@F?GEJ=6BCC)J:IBHB?@B@>C>BBG?EFEIBJH@B5=B-A+E7G;C8,D(FHG1IDHGIGHBIEE/EHFC>>/BF@ICHGDI@@D.EA7B5/C5F=I?DIH=>I,=DHF7ADHH9D>@?@=B%:9C2>EHHE2GHF5@;G>>$79@)DFJD>=EB5G54C:CBEC?:@?D*IA@EECIC7@AEC>@BH?BGHDEFAIB?DGGFI?@>BFI@FF8DGG=BF9CFIIBFB4:ACAJ=GAEHHDD@;%IH@IE<=AEDG??>BC(CFEGCF:=2BA>FF>BF>GCB/E3IBEG=CF@4HCCBIEE?848A*A1='=E?FBEHABCGE>-DDDC>EEG8HH2CJ>FGACAB2;E0D?>9=>E@FDC*C5IH@BID?EA1FJGCIHBHGIAD;./C4>:JFDD@ACHFHCE>?A==EABBHJE:G(GCEGA5EHAFAHFEG*EA@=?E?=#DIFBIGDGG;)*E$FIGJF>DEAFHB8ACCEA>'?IF>DB=7>3IEE%.F>BD*AB(?H?EFDC=G)IGH:C?*>E?BGD=FG8CF8DEIFIAB?>@AB=@:CDG+CBIGFAB,FE?GE?AF-A?AGHG?I@3?CGFGD@CHIDGD@>FH,I>A@D>;:;FC?H?B9HEDB5HD@7D@BBDDFE=CG>CCD5BC05F?E@>>>6;FCG9?EG=?>AAH>BDGGHFIF;;.DDIFDDD8I>CD=@B>>B$@@B@C5:E>CC7C957?ABFCAG@9E1CFBD=DGCA?BE96&B785B@ABF;BDE1CC=B3/8CA@@;B3CCDCEFA6@<:(AA5>D/?DDBB5AA6=;;;9/@@6>6=A>G6E??FC;<;<15A9;:7;@CD>@?B9A-:B;=4:483;=F @rCer/228/25_2401_CCS ATGGGGGAAGTAGTGGTTGTCGCGGGGGAGCCGGAAAGATGGTGGTTACCAGATCCGCACGGGCTAAGGCCAGCATCCAAGCCGCGTCGGCTGAAAGTTCCGGGCAGAAGAGTTCTGCTGCTAATGGGATTCAAGCGCATCCAGAAAGTAGTACTGGATCTGATGCCCGAACTACTGCTGAATCACAGACCACTGGGAAACAAAGTTCAATCCCTAGAACTCCTAAAGCTAGAAAGAGGAAAGAGCAGAACTACAAGCTCACTACCAAAGGGTACTGAACCATCTACGGATGGAGAGACCTCTGAGGCAGAGTCAAATTATTCTTCTGTGTCTGAGCACCATGATACCATTTTTAAGGGTAACTAGGAGAAGGCAGATCTTAATTGCATGCTCCCCAGTGTCCAGTGTTAGGAAAAAAGCCGAAAGTAACTCCAACAAAGGAGTCTTACACTGAAGAAATAGTCTCTGAAGCAGAATCTCATGTTTCAGGTATTTCTAGAATTGTGCTTCCCACAGAAAAAACGAGAGGAACCAGAAGAAGTAAGGCTAAATCTCTGACAGATCCAAGCCAAGAATCTCATACAGAAGCTATATCTGTTGCTGAGACATCAAGCTCAGACATTTCATTCTCTGAAATTGCAACTAGAAAAACCAGGAGTATGCAGAGGAAATTAAAGGCACAAACTGAAAAGAAAGATAGTAAGATTGTACCAGGAAATGAGAAAACAGATCGTGGGCACACCTGTGAATTCAGAGGATTCAGATACCAGACCAACTTCCATTTACAAGCAAGATCTCTTTCTGAGATAAATAAGCCAAATTTCTATAATAATGACTTCGATGATGATTTCTCCCACAGAAGTTCAGAAAATATATTAACAGTGCAAGAACAGGCCAATGTTGAATCTCTTAAAGAAACAAAACAGAATTGTAAGGATTTGAATGAAGATGCCAATGGAATAACAGATGACGGGAAAGAAATTAATGAGAAAAGTTCTCAGCTGAAGAATCTTTCTGAACTTCAGGACACTAGCCTTCAACAGTTACTTTCTCAGCGACATTCAACCCCCCAAAATAAAAATGCTGTATCAGTGCACTCTAATCTGAACTCTGAGGCTGTAATGAAATCATTAACTCAAACATTTGCAACTGTGGAAGTAGGCAGATGGAATGACAAGAAAAAAAAGTCCCATAAAAGCAAGTGACCTGACAGAGTTTGGTGATTGTGGTGGTAGTGATGATGAAGAAGAGTCCACAGTTATAAGTGTCAGTGAAGACATGAACAGTGAAGGGAATGTCGATTTTGAATGTGATACCAGACTATACACGTCTGCGCCCAACACATCTCAGGGTAAAGATAATTCTGTCTTATTAGTTCTCAGCAGTGATGAAAGCCAACAGTCTGAAAACAGTGAGAATGAAGAGGATACTTTATGTTTTGTTGAAAATAGTGGTCAAAGGGAGTCATTAAGTGGAGACACAGAAAGTCTGTCATGTGACAATGCATTGTTTGTAATTGACACAACTCCTGGAATGAGTGCTGATAAAAATTTTTACTTGGAAGAGGAAGACAAAGCAAGTGAGGTTGCCACTGAGGAAGAAAAAGAAGAGGAAGAGGGTGAAAAAAGTGAAGATTCATCAGACCATGACGAAAATGAAGATGAGTGTAGTGATGAAGAAGACTTACTAAATAGCACAAAGGCTAAACTTCTAAAGTTGACAAGCAGCAGCATAGACCCTGGTCTGAGTATCAAGCAGTTGGGTGGTTTGTATATTAATTTCAATGCAGATAAACTACAGTCTAACAAGAGAACCCTAACACAGATCAAGGAGAAAAAGAAAAATGAGCTTCTGCAGAAAGCTGTCATTACACCTGATTTTGAAAAAAACCACTGTGTTCCACCATATAGTGAATCAAAGTATCAACTTCAGAAAAAACGCAGAGAAGAACGACAAAAAACAGCAGGGGATGGCTGGTTTGGTATGAAAGCTCCAGAAATGACAAATGAACTGAAAAATGATCTCAAAGCACTGAAGATGAGAGCCAGCATGGACCCAAAAAGATTTTACAAGAAAAATGATAGAGATGGCTTCCCCAAGTACTTCCAGATTGGAACCATTGTTGACAATCCAGCTGATTTCTACCATTCACGAATTCCCAAGAAGCAAAGGAAAAGAACTATTGTGGAAGAACTGCTGGCTGATTCTGAGTTCAGAAGATACAACCGAAGGAAGTACTTAGAGATCATGGCTGAAAAAGCAGCAAATGCAGCAGGAAAAAAGTTCCGAAAGAAGAAGAAATTTCGCAATTAAGATTTACCAAGCAAACTGCCACATTTTACATCGCCCCTTTATTTACTTATTAAAGGCGTTTTG 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rCer/229/2011_54_CCS GAAGTACATGGGGGCGGCGGCGAGCGGAGCCGGAGGAGCCGCCGCAAAGATGGAGGAGCCGAGAGGCAGGCCCCAGTCCCTGCGGCAGGGTGGCACGCTGACGGGCAAGTTCATGAGCACATCCTCTATCCCTGGCTGCCTGCTGGCGTGGCACTGGAGGGCGACGGGAGCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCAGGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGTGAACGTGTGGCCACCAGCATGCGGACGGTGGGCAAGCTCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCATGCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAGGCAGCCCACCACCCACCCTGAGGAGACAGAAGAGGAGCTGACAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGTGGCCGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGACTGTTATTAGCACCTTTAAGAAAAGAGCTGTTGAGATCACAGGTGCCGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCTGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGGCTTTACTGGCTCAGTCCCCAACATCCCCACCGAGATGCTCCCCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCAACCAGTTCAGCCTCTACACGTCTCCTTCTCTGCCCAACATCTCCTTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCTGTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCGGCGGCAGCGGCGATCCACAGTGATTCGGCCGCCGCGCCGGGGGGTGGGGGGGCTGCGCGGGACTCTTTTTCTTTCAGACTGACCGCGGGGCAGCTGCGGAGCATGTCGACCCGGCCCGAAGGAGGCTTATGCGGGATTTCAAGCGGTTACAAGAGGACCCACCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGGTGGAATGCAGTTATATTTGGACCAGAAGGGACACCTTTTGAAGATGGTACTTTTAAACTAGTAATAGAATTTTCTGAAGAATATCCAAATAAACCACCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAATGTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATACGATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGTCCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGAGTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAATAGACAACTGGTCTGTTAATCTTTTTCATCATTGTTGTGTATAATTTACCTCTCAGTAGAAAGGCTAACAAATTTTAAGTGCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAGTCCTTCAGTTTAGAACCTACAAAGCTTGTGTATCTTGATTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATTTGTAATATATCCTGTTTGTATTTTTTTCCAAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTACTTTTTTCAAATATGAATGCCTTATTTTTGAATTCTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATACATGTAAAGCTGTTAAATACATAACTTCAGT 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'$&,)**)*)'%&$'($()$&&'++/)'*1)/+,1..01%1--2/33,03,6(2581671866470410+,#'$.)24215343-11(-%180874-/51247938805<-01.:/9:950(=5744838?2==4<668/47047&8:58.:3974668;(=<75:8162=08%/77;%112=.7477-20.9<9<78:45;::816099::<8;437,4*:7>965939=6177<4=96<93?:957;56.972=81159<.6:58=367.)#14650464-3.8055714-(1=8=029?::;;(;8--960#20').4;080468/9;6-1':9::64839;999<6275197/;;51&)*8?=4;9);5*38788;:)8:?504676.616420/37174/4<84;)018+*95=05-28:;770,;8==7=:4;>>;2)8>1==.747,36:/738032;8442);8987;9/893:478>/<<69781-212;87;-7;899=<5045*::;>>><<=8)36=;6;3<:92=?491862986159>9:?;7=6<.0$2;:)5.+435479&:-::<;.0219.<)3<=><&(046627;280:<3=99,7%(89<;763*;;;9:/54.4*49:6+0408<<8/310256265:4.>:5151)9>;;75654;:=73228>;=;<9<396<433489*8:15:319(:.=54:856)87031+72=;476:847=77>049=/96;>16+787799;)=55.:;:?65?<8;99-,($633$1:=7?<958:?49;;<<3;7*8<3,.10'&%-081*8?;=;:>;:/37749:8:9=4;-5<<=467*<2>8/0=<<;*<932?-<8.@/?3:4@?8=BC>4:?=@9?649?7/)>67?A>6;<0;??<4@;2;=/<4;79621/*&7;658.>8=2):65?@@6=92:B:=@?:<'>262/26>9>983473<635@>4>191/<=<.48412/'4763+/0#,36989:;024697653$6:;7:=:<65.99<<<<>@2==3::=<797:963<=887@>(8;=A3BC7A;?A;9;,4=>>><2=:?9BC=B@C6B4=A@0;:@?=BB63B625/)-'686:;<:;5=9=4:6BACA:<78/,,)<3<864285.%450862@;:4;17?7367*9=4:8886<C8=9;<73@=<>>+38+573@93-/<:5,<@@(28:@/81-1<<@854%217(=399;@55=;=/?773532%77?;:==67977*0206398'88;4#/674615275>=;51;633>:49.02<793<:8/98-:9:79>2186<:<6&83:;>;7;4;:3>354836<7<72179=5:2=:9/)/53><6?4=<583772;==>:.>9=>:9?658<*?;/9=?:6909>:>>;<>=:<63><:18=<5/76382<<:58<8?=<=5<=6<=.89:+77/=9?:749=12-995682.,>:53:/9>=7;(=789=;==1235:9812:-;<5325?637&:=897778<>3782+?6;=825?<9?8?34,568<83>=?>:??43,=958056=84:=8;9;83)2888;;'39=.=>=>6>?7=8897078:8:#:.>=61;<6*025=87,7+=>860;;<1(*/.=;8*9:><85<3=9;8;=8<:1989<114>>:974:<1)27;0,0.98??9>:8;9;:9:)=:?;>;;52+-+99;/>73<9<97/<=9)78>861+68(989268848;9':579';6<7+:38;;;:%96,*82'0*14381:43//#1>=0=;<=3>=66<241&<;91=?9<=2;9=> @rCer/230/1733_55_CCS ATGGGGCCCTCCCCAGAGCGCCGAGCTCCAAGCTCCACCCGCGCTTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAGCCATGGCGTCCTCCGCGGCCGGCTGCGTGGTGATCGTCGGCAGTGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACCTATGACATTGAGCAACAGCAGATAAGGAATGCCCTGGAGAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTGCTCTGAAAGGCTCCCTGAGTGCCGAAGAGCAACTGTCCCTCATCAGTGGCTGCCCCAATATCCAAGAAGCAGTAGAGGGCGCCATGCACATTCAGGAGTGTGTTCCAGAAGACCTAGAACTGAAGAAGAAGATTTTGCTCAGTTAGATTCCATCGTGGATGATCGAGTGATCTTAAGCAGTTCCACTTCTTGTCTCATGCCTTCCAAGCTGTTTGCTGGCTTGGTCCATGTAAGCAATGCATCGTGGCTCATCCTGTGAATCCGCCGTACTACATCCCGCTGGTTGAGCTGGTCCCCCACCCGGAGACGGCCCCTACGACGGTGGACAGAACCCACGCCCTGATGAAGAAGATTGGACAGTGCCCCATGCGAGTCCAGAAGGAGGTGGCCGGCTTTGTTCTGAACCGCCTGCAGTATGCAATCATCAGCGAGGCCTGGCGGCTGGTGGAGGAAGGAATCGTGTCTCCTAGCGACCTGGACCTTGTCATGTCAGAAGGATTGGGCATGCGGTATGCGTTCATTGGACCCCTGGAAACCATGCATCAATGCAGAAGAGGAAGAAACAGCAGAGCGGCAAGGTGACCATGAGTCGGGTGCAGCCTGGCCTGGACCACTCTCCTCATCGAGGCCTGGATCTTTCCATCCACCCTCACAGCGGCTTGACCTCAGCCTCCAGGAGCGCTGTGCTCCTATTGCCTGTCCTCAGACACGGGCCCTGGGTTGCCATATTTACCCCCTCATCCCAGGGGTCACACTGCTCAGGCCACCTAGACCTGCTCCTAGGACAACTGGCCCTCATCCCTGCCCCAGGACAGACAGGAGCTCAGCAGAAAGGCCGCCAGGCTCTTCAGAACTTCTCTCTGCACTGGGCTCAAGTGGCCGCACCGGGCAAGAGCAGGAACCGTCTCTGTCTTCGTGTTCATGTTGCAACATTTCCTGCTTTCCATTAGTTGCATCTAAGTGGAGCATTTAACGAATTAAAAGAATTTCCAGCACCAACTCCTGGCTTAACCCGGCTTACCTCTTGTTTAACATACTGATTTGGATTTAGGGTGGTTTTTAAGAAGGCTTGTTCTCAGTGACAGTTCCCTCTGGACCATGTCACCCAGTTCTTGACCAGCTCTGAAGGACTCTGGAGGCCTAAGCAACTTACACACACACATGCACAAATCATGAGTGCTTCAGTATTTCAACCTGGGAAGTTTTGGTGTATGACATTGTGATGTTATGTTTTGTGGCACGATTTTTTAATAGAGGAGAAAACAAATAGTTTCTGGCTCCCTGTAACAGCACACGCATTATAACAGCCACTTTCTGAACATTCTGTCATTTTCCATCCATCCTTATTGTACCCATTTTACTCATACGGAAATCAAGTCATACAGCCAATAAACAGCAAAAACACGACTGAAGTC + 1,06:+??99::<*:7689<9:>>:>481=77:9:<;??7=<97<8:+;>713:<89>4=9?;>=;9::29<<9.?6>?86=:8595,789<68/876=1=0.+/:6=8:2/78>7::53=53273$176379:?088:;;6;78;*>59;908999/;;42=<=8>?=9:-:*:7(9:<84$3,63=>;178,*556,>=7<15<;1-60:,-53<235=<:=4485:9=7=.78:898:52774493:,:;69<-8174;79+75:<6.>:,369+6/.7<5736<309714.97:9=>5<;99:62.=997:564.9-;:6:/?55:2446.*497;;7>>=4=0>=;;:51:14062677784;27:62<9444<8;2988;6;?7>>:9788:)==<;75>9>=>:>69682=8:6;84159=:8;<7;589843.>::8>2817:;=6;;/<54;7=:87;<7;73+885=8;<2?9=930/,+4$679-354'478;<11=98:<=?9==>:<:1+-94:(7:86211228,508206384(06.27-770:247786:15)1.,0-53-6-414./6..26688+1*1,28778,656-6/'..4;7965&2593495:841-4102)49617/$$.25*0814:19453549/9;452'2:;:48,19.91:6./.9908475;9.08:835.9:3,599,9-'986:508855589.;:4/8577;8106671,)6640304313%(1+85-9+1+0/.7691-9::4:469:46-69:379:958358;/98/207719-(-1%-6545&496-44.06/3*6739:9741375371558757675:;-$'.470;3'7:477:131::879:378-947437936056233-22::7:845317/3:853408399,./.7643356(+8'290-8--2+,203:2/1527)449:86&1779,6643+239//13./7,/:09559:2855:957.5/688475:19703345:709:998(08+6645:3881:76312275439062;9993:;85+7/0//7715428463365816/47'2::;9639563::6;899*3;9/0981:86%3/75729:7648./07433548723873*.,6148213/:218358-57:68814:7:608;55/4451/7429847%8:5,02+46)4/.10/4.-$-&4/985:955-::2;79:5:;949:/9765:547583'40--)96683-486+/7,8344&3.95,0-99020(4037921857951::6327:368-,1465275*263&,5.6:5::5:5:84/.9//95:99*39+24.42684-35-56,--*,1798/875356'77133-7:68-96595/54.27(:5*1:-8-08:9+93,/,32.9:96&765.378.458:750958213,+310213%502536..2236-$-/8*.3:7:1,9;69';;26:63145:3-438-326+--85949503573''465.:92'5:::6+5+2%45026824258132&'365645334(,2-%14/;<:=60:=936;.=.6;49>7;<:==508:52898*:1:82<8<:*799 @rCer/232/1581_57_CCS ATGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAAGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTT + KKKK3KDKHKKKJJKKK*KKKKGKKKJKHK@KJKKKJKKKKKK2KKKKKKKKKKKKKK>KIKKKKKKJKIKGKKKAKKJKKKJIKKKKKKG3KK%KKJKDK8KKKIJKKKKKKKKKJIKKKKKFKKGKKDKJKKKKKCKKKKK?K+KJJJKKK+KIKKKKKA>KKKDKKKKKKIKKGHKKKKIKKKFKKK8KKKKKKKK;KK>KHKKKKK=KKKKKJIKKHKGKKGKKKKKKKKK+KKKKKIKJKAKKKKKKKKIKKJKK5KKK7KKKKKKK@JKIKKKK.FKKKKKHKKKJKKKKKKKAFKKKKIKKKK0K@KFKK1JKKKAJKKKKJKKKKKKKDKDKK2KJKKKHKJKKGKKJKJKKKKKKIKJKDKKKHKHKKKJKDKKFKKK9KKEKKKKHKKJJKKJKKKK4KGKKKGKKKKKKKKKHKJKKKJJKKKJKKKKI:KEKJJKKKKKKKHKKKHKKKKAKIJKIKKKGKKKIKJJKKJ4JKEKKIKKKKJKKJKKKK3JKKKKKKKKK:KFKKJKKFKCIJKKGKKKKKF:IFF=IB@C(JKFJJKIKGIKKEIKFKIIKEKKJJKIJKKJKDKKKK?KKK7KJKIKKK=KKKKKEKIJKKKJKK7KKKK;KIIKHKKFKKFKJHCKKKIKDKHKKKKGKKJKKHKKJJKKKJKJK;KJKK>KKKDKHKHJKIKF@KI;K;JFJJKKKKHKKKK@IKEEJK@KKKK>@KKCKKKGKKKJKEKEJKFKKKKKKKKKKKJKKKKKKFJKKIDKKKKKJJKGKKKIJKKKKKKKKKKKKKAKKIKKBJK8EKKKKKKKJJKKKKGKEHKHIKKK5FJ7KJIKKKKIJK?KKKHHKKKGKKKKKKKHKKKHKKKKKKGKKK+JKKKKKKKKDKK9JKKJKFKK9KK5HGIK2KIJKKKKJKKKKKKKKKK>KKKKKKKKKKKKKKKKKKKK8KKKK+KKKKKKKKKKKKKKKKKKCKKKKKKKKKKKKKKKKEKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKK,KKKKKKKKKJKKKKKKKKKKKKIKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKDKKKIKKKKKKKKIKKKKKKKKKJK@KKKKKKKKKKKKJKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKHKKKK5KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKJKKKKKEKKKKIKKKKKK4KKK @rCer/235/25_1927_CCS ATGGGGGCGGCCTGCGCCACCATCTTGCTTTCCTTAATCTGGTAGGACCGTGTGTCAGAACAATCTTGAATCATGAAGCTACTAACCAGAGCCGGGTCCTTCTCGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAGCCTCAGGACCTTGAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATGCTCCTCTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTCCAACAATTTAGGAACCACCCATTTGCTGAGACTTGCATCCAGTCTGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCATGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAACCATGGCTTACACTGTGGAATGCCAGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTACTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGTTTGGTTTATCTGGTGTGAAGGCCAAATACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTCTTGTAGCAGAGAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCGTTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCGACTCAGCAGCCATTTGATGTTTCCGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTCGGGATTTATACTATTTCCCAGGCCACAGCTGCTGGAGATGTAATCAAGGCTGCATATAATCAAGTCAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCTGGATACCTAATGTCAGTGGAGTCTTCTGAACGTTTCCTGGAAGAAGTCGGGTCGCAGGCTCTAGTTGCTGGTTCTTACGTGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCTAACGCTGATATCATAAATGCTGCAAAGAAGTTTGTTTCTGGCCAGAAGTCGATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGCTGTAATACTGACGCACACATTACGGGAGAGAGCTGAACATTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAATCTCTAATATAACATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCTCAGCTGACCTAAAGTCAATAAAACATTCTGCTTAGGTGTTTTTCTTACGTTTTTCTCAATGAGTTAATCAACAAGTATTTATTATGTGCTGATATTTTTGTTTTGGATGCTTTAAAGGAGACAGGAATATAATTATTGAGCATAGAAGCATTAGAAACTATTAAAATTAAGGCTAAGTGGCTATCAGTATAAATAGTGCCAGGTTACTATTGGTGGCTTTTCAGATGAAAGCAAGTTCAAAATTTGTCATTTTGGGTATCAATAGCTAAATGGTCTGGTTTTTACCCCTGTTTTGCCTTTTTTGCAATAAAATTATTTCCGAAAAAC + DKCKKKKKKKKKEKKKJKEHKJAIIKIK8KKKKKK=KJIKIKKBKKFIK;JCKJHKKJ@KJKKHJJKKKKJKKIKKKKKGGKJ=KKKJJKHKKIKKJIKAKJHKJKKJKJKK7KIJCKHJIKIKJIJJJDJJGJKCIKKJJFIICBKJJKKKKKGKKJJFKKKKJKKKK>KKIGKBKKJKIKJ+IKJ@KJ8KJKJKKKKJKJKKDKJKKFKKKKGKHKKFHJJKKIGIIKJGKIKBKDKKK4KGJCG:KKKKIHIJKKIJHJKHKKKJKHJFGKEKKKKJIKKIKFKEH>BKII6FHIKKKJJJKJHKIIKKKJJKJFKJKKJK0KKJIKFFJFKIEKJFKJI>KKAIHHIKKIIJJ>JJKIHKDKKK=KHKF>KGDKJEFBKJFKIAJGK;F?KIJK3HI?KKHKDKFKDDEF2GGKKAFKHKIHHKEHG4BF@2JEKK?K?5JI@KHD/HCHKKE3JHJJH=HHGKFKHJC@KFD=ECJGHDKAI/IEJJAKKGK;KICBID?FJIJJJJ7KIKFDKHHIKKJAJK8KKEJJJ4J2IEJI%JJIBI7IJJHJKEJKKJ7KJ;JKEIIKFJ>I,DCFJJG@IHKCK@JFDHCKJJIKHCJHJFJK@AHB@J>CHBH?KBHHJFKHHKGKDKHHFJF5HKGHDJK?IHEFJKJKKGKJGIKGHJJJKJKKGKK;JIKHDHJHAKKCKII-FFFHHH@JKEKEF@JIKJF=KG;=HJJIEBKKDJIEJGJJC:JJE;HGKH@EKEG=67DEEIHI>KEKJFGJFIKGJIJKK=IJ@KFKGCKK;JFFHFJJHHKK>HIIIJJ7HKFCEDG?KK.I=FDI=EIKI@FDKKJDKJEKKKKKJKJCJKJ>JHKDFDEFGGKEGJIKJGKJ8KAJ6KJKJHJDHIJH:=G=@KKKK)IIJBII8JKFGKJKHK9KKJK@KKDI:HI=IJJJFH:IK6KKKJKKK;JKAKJJKKHKK=KKJGKHKEJHBIDKKKKKJJGGCKKIKJGKJFIHKJJCIKJKKHKHKJHKBKJJKKKJKJGKKKIKKIIGJHKJDKJKKHKJKKJK9KIKKE<8KKKKKGHKCKJKKKJKIKKKI@KEKKKGKJHAKGKKIHDGKBDHI@KKGKKKJK2KKKJIJHKKJ=KKJKIIIKDEKKKIJIKJEKJGKKHKKHDKFKKDKKIKKKJFCJKKIE.IKKKHKKIIHJKJIIGCKDKKIKKIKECHEGIEKKK@JAKKKI?IJIJ@KKJFIJIGEDKH8JIKFHKIGIK@KKKKKKKJ-KKIJIJJ:KKKJJJHHJHKK8EIKFKKJJJ?KKHJKIKKEBKIKCH4KKKFHKEKKHAAKKIKEKHKKDKBEKGKJGKJJKKJKJKJ:IHKHJ;KC=KKKJFFJHJJFHJHKKHKGKKKKKKKGJIKIKJKJH>KAKJJK@KCG=KKEFJ;G5FKKFKCKBJKK?KKKGKGG/BKIJ?.BBGKIGIJKKKJIJ1KDCHIGBIEDFG8GGCF5BCHGCHJ;JG6FIBJGGGDIH3@C@;GBCCA;89=<+;,:*F8BJAB55DJ=?CI9@C9>7EFCG@BA8;9GIHG>430HIJFIIJHHADG?EEK18J;IG@=0AB>E@A:J@F-A>JHGKIKFG08<=C@CHKHCGHAEEE.IGI>19-@642+GD@FD8>?H9;@?I6GJGIJC8DCJCDHKE?B?2?.I>8H4F;3=;JFCG:9,2AHB=9AF4-CIEKACHDFCEAH@DEHFJCEBBE@HII@@:KJBJKDJ?A2/1@9>@JK9JI;KDKKKEKKAE8KII:H9:7CEE:EB7>JF=JIKKHJ>9IJ.HEEC?EHGJJ??JEHBCJI?G6DF?AEJI@FE1/3D977;;0@E<@0;@D>JE>GEHCI@CF?>FGGKHKIEJCJ@BBE?FKKG2J;A?=-?G48D5DFJ;GCKBKEH7IJKJJIKCG;G>>9EDFEH=E=IFKKKJFH=KFKCH?BGEIGIA?AHB=:HHGFKAHAJ=AFEEAIHHJ?@HJFAGEBB:I;JJJJCJFKHKBKGDCIKKK:EAGJDGGIEB6;;5:(654:>IB>JKAFIGJJGKD>5?GAB<8DI9H:C<6ECCJGKH;EJI7BA@:>8:G=6>9EEI3GFGDBB8@7=.FD:C1JJBH5BED@4GEJGJ&HD=FGJCDD??=%@EC?BKB?@>B>:F1?5A>E4DA=BDG9GKAHIGKHCD2C<=><=F=J3AI.FBB3J@A35CE-E;6FIKI;27)4+64@H:CIAEJ>CE>*<@HIBJHJJKGAI@EBI3JJJKKJIDKJJI@>?3-9AH7ABCKFHAEGIKGJFJDKEK;IFJJ>GEAIC@@@AB55@AD7I?>4HKEAI>JHEF@IAAEFCB3GD?C7>C7HAC@7>>E0CAEBJ9=DA85:C?:CECJJAH@GFC7DG9IJCFF@BI:>HGDKDJBGF;IHHB'=DK?K>C?7@8;>EB7A:BD8F8DAAF>A6=>?HGD0G@BD=<8AAB-BB?=?<*BB.7@FGCIFIIGEKIDEH=KHIBIG @rCer/237/1627_57_CCS ATGGGAGGCCACCGCGGCTCCGTTGTTCCGCTGGGGCCTCCGGACGCGCTCCCCGCGCAGGTCTCTGGAACACTCGGGCCGAACGTAAGCCCGCTTGCACTCACACTGCAGTTCACACCCGCAGGCGCGCTCGCACCCACATTGCCGCTCACGCGCGCTCACACTCCCCACGCGCGCTCCACTCCCGCTCCAGCCCGAGCCCGCGAAGGCGCAGGCACCGCCGCCGAGAGCGCCAAGGGCCCCACGGCCTTCCATGGCGGACCTAAGCTTCATCGAAGATACGGTCGCCTTCCCGAGAAGGAAGAGGATGAGGAGGAAGAGGAGGAGGGTGTGGAGTGGGCTACGAGGAAGGTGTTGAGTGGGTCTGGTGTTTCCTGATGCTAATGGGAAATACCAGTCTCCTATTAACCTAAACTCAAGAGAGGCTAGGTATGACCCTCACTGCTGGATGTCCGCCTCTCCCCAAATTATGTGGTCTGCCGAGACTGTGAAGTCACCAATGATGACATACCATTCAGGTTATCCTGAAGTCAAAATCAGTTCTTTCGGAGGACCATTGCCTCAAGGGCATGAATTTGAACTGTATGAAGTGAGATTTCACTGGGGAAGAGAAAACCAGCGTGGTTCTGAGCACACGGTTAATTTCAAAGCTTTTCCCATGGAGCTCCATCTGATCCACTGGAACTCCACTCTGTTTGGCAGCATTGATGAGGCTGTGGGAAGCCGCACGGGATCGCCATCATTGCTCTGTTTGTTCAGATAGGAAAGGAACATGTTGGCTTGAAGGCTGTGACTGAAATCCTCCAGGATATTCAGTATAAGGGGAAGTCCAAACAATACCTTGCTTTAATCCTAACACTTTATTGCCAGACCCTCTGCTGCGGGATTACTGGGTATATGAAGGCTCTCTCACCATCCCACCTTGCAGTGAAGGTGTCACCTGGATATTATTCCGATACCTTTAACTATATCCAGCTACAGATAGAAGAATTTCGAAGCTGAGGACGCATGTTAAGGGGCAGAACTTGTGGAAGGCTGTGATGGATTTTGGGAGACAACTTTCGGCCCACTCAGCCTCTTAGTGACAGAGTCATTAGAGCTGCATTTCAGTAGCCAAAGAGGACAGGAACCCTATCTTCATGAGGGAGGAAGACAATGGTCCTATAGAGCCCTTGGATGAGAAAAGGAAACTTTTGAGCTGCACCTTCAGTTTATCCTCAAAGCCTGCGTTGTCTTCATCTAATCCAGCTTTGATGGATGTCTGTGATGGTTGCCTGTACACTTGCTGAAATGAAATATTAGAAATGGCTGTATATTCCAAAGAAACCTATATTATATATCCACGTTACTGCTGCTAGGATTCATATTTGCACGTACTGTTTATTGCTTATGTGTAGAGGGAATGAAACTAGTTTCCAGAGTTGTTATTAATCTGAATATATATCATGTGTTAATATTGAGAAAGGAAAAATACATTCCCAGTGTTAGTAGTTCTTCATTTCCTGTCTCCAACAGAAAATTAACTCATTTTAAAACTAGTGTAATTCTTGATAATAAATTAAGAGTTTTG + JJKK$FHDKKKJ%I:K,GKK>KK?KKAA?KJKKKK0K,GKJK5KKKKKKKKKK)JJKJKK>KKKKIKJICKKKCKKKKKKJIK>JJJKDI,JJKFKKJKKKEKKKKKK*FKJKKKKKK/KJJGK)KJK&JJK-KKJHIB6KKKKK;KKKJKKIKKKKKKKKGKKKKHKK*&GDJG9KHKK9KJKKKEJHIK=BFF'*I-IIJH>D?FD<:IKKJKHKHKKKFJHKK?J>AKHF'GKJBIJ/IICJIG4KGDKKBJKKHKKJKKKKECKJB?CIEKBHIJJKD=<*=IIHF>JII=)GKH6KIFKKGDKKAKKDKK8F9?FJ@?+FCB9JKKKHJKKKFCKJKJKHH=AJKJHDH;JKKKHIJ@KI>FJK6JIKG5JHII?KJKFKDJGIJKK@GDK?JIHDIKAJJEGDEJID>DECGJ&KHKKIBJDHJJH*KKKKHFKKKIJAKKJKKKK+K:KGJKI.EFJEIADGH>FHKIIIIEGGJHJKKI=HKB@=BHKIIJKHIHAAJJDKK?KKJKHKCIJJKHGIJ7KJFEKK6AHKIKJGCKIKHKKAKIKKKDG4/KJF<;HJHHGGJEKH=GBKCKF@KKKHK:JFIDDH7JEIHFIKJ9IF>GDKJCFFKIKJKKFJK@KK?GEKKKKKKCJJIHE8DKKKCFHIBIJKEHJ@HDJHK>KKIIH=JGIKKK;KK6KFJJKK>FKKKGJKFKGKA;KCFBKKIFKIGJKKK&GHDKHKHKFKKJIK=JKKHK@KHKKKJHJKBI'IIKHEGKJ6K9IKKKGJKKGIKKCKKKK@FKKK>JB?KJKKKJJKIJGKJKK;KJKKJKKGKK>JKK+KKKKFKKKKKKFKKJK@KKKKKEGIKKHIJEKKKKKJJJHKKKJKKKFKI1DJHKK@KKKKGJKHIKKKKKHJKKKKBDKKIKHJKKKDKKKKKKKKIKGKK>KKHGIDIKHKDKKIIJ7KK%KHKCK@JJ@JGKKKKKKJKJKKFKKKKKKFKKKKGJKK>KHKK?KCJKKJKKKIKKK?KIJKKKBHCJJBAJCKKIK>KKKFJKK?EKKBKGKKJKKKKKFKKKKKKKKKJJKKKK4KKIIKKKKKKJKKKFKIKKGHKKJEJKJ?KK8JKIGKIDKK@CFKJKKKKAKKHKKIIG>KKIKF@KGKJEJK8?KG @rCer/241/1852_59_CCS GGATTTGTTTCGGGGGATAAAGGAGGGACCAGCCGCTCATTCGAGAGGACGCAGGAAAAGAAGCGCTTCAAGGACCGGGACTAGTGGCCAGCTAGGTGAAGGCAGACAGCGAGTGGCGACGATGTGATTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACGATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGAAGATGATGAGTCTGTCCCAGAGAACGTGTTGAATTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCCACAAATCAAAAAGTCCGACTCCTCATGACGAGCCATCCTGAAGTGTGACGCAGAGCGGATAAAGCTGGAAGCAGAGCGATTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTGCCCATCAGTAACGATGAAGATGCGGCAACAAAGAGTAGAGAGATTGGGGTGATTGTACTGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGCTGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCTTCGCACTTGGAAGTCGGGCTACACTCCCATTTATACCCCCTTTTTCATGAGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGAGCCCATCGCTGCCTGCACCGGGATGATGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCACGGCCGTGACACCCGTTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCACATGACAACAAGTCGTGGGAGATGTTTGAAGAGATGATTACCACCGCGGAGGAATTCTACCATCCCTGGCATTCCTTACCACATCGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCGTACATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGACCAGGAGCCATCAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCGGCAGCAAGAGACGTCACCCTAGAAAGCAGCTGCAGAACATGGAGGTCACCGATGCCTGAACATTCCTGCGTCCCTGTTTGCTTTCATTTCTGTCCGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCGCCCTGCCCCCATCTGACTGTGGAGCTGAGAGGGGAGCAGTGCCATGTACCACACAGATGTTCCTGTCTCCTTGCATGGCATAGGAACCCATCACTGATGACTGATGAAACCATGTAATAAAGCATCTCTGG + '%%%'$'''%'(%%#$()))()%#$'#&#$$()($$$$$(()%"%#&%((((()($#"#$'#%()()&()(##&&#"%"##&&#"#"##$%$#!#!"%)')+-((',(+'*,*+,%(/1510/-#%(/*04014+.015/13))10//'41416021)5,1.-24102651+.-//1654.22/01%25/4,*,*)$$-/+2.21061+.012*1*/-&/+'-441(.,+&+$+54-0%00255..%-265626456434.523,.1/.0-21++1//2461/).*)%*.221/*0()0%40221'$'*%,*)#121.$-0*11655/,)(.00413*3544/*410.21-2.(2)1.//-*/+52(/$44,+%..-653435/*.+01(4)5/3-1+..-11*.*14//34')*5/3+421510254(.3/466%,.#21/+'+'*41)()&(3$)##)15320%())./221612+0+/0-/4/+/00230/'01-,41+$'.0))(,)-+//*//4)/4-3/02-44,)&&&%%&.,-(2&$*7+.-03,-+.%605:7(6485(97/2)41(0:66:;990,2+12..28954543393+44,22:+53'3-1$53+)*'*332,#(-.0/.254)453(**28887/8861,2724511,1,.92404/3::3032036.743.47..86825988-02//--47174-,.240722704-57-5+976.7-785.(1'817817+&8*7,+$',#13343/.(3885%,//1*5:1/4,14+2-$013:06606448(*+81.0.31%+)2#+0-12670-3-3329652876451/,-,$364)465938-01*3,366981/$3&34+30-0+'6*+*-+.0*/650..-,-+546-15/(:1.1.12/0'52--6.253.0-6&457808/5*791:639835/791334466682121-0-,6*20+210651514440050-35--*.(+/).'*+*45/4461,-)0.4'1015("/-+%00$+$32242&300154611/242432015303/..51143).401-,./2236.13/63550544,%40+1/-/0,3/,/-54/3+-3-//*-6114640(6.2.04+$',/-.-,///+0)1.5140.1-(',$00*0-*10*/-,0--++1*,&',).-(/+21*-%""$)+1.--/,3/(63--+&,/-2542--4.+(1001142-+*)0/1(1/.(&-1,+1)0.*0(/0'54113..-.3426040/503+552*-41.0-0*-&*(0-0.2.202010.14040556524.+1/23(#-./1)33.-13)(&*$001//.+'$)-/0+1414/.5+55/005+,0+0-)-/1..)315/3-&0/.)21224)20,)6221&3/+$-3'%+41+*.1&31+0-*(+05150.,03(5212*4//4*--3'*.$-*/0%2-3/3300&.450/1/1012&*/543232'&.4),%*.4-.)3+430341,0.&+211352*+20$+32--44(*0)1)1-2.054+5404-3230/1./302/1/.210%101,/25/*)3440*+*.5652.-//53(3422231,(./15-4-110412226-,234*4..32-25.+-'.561/00563,)3--3/*.0.*000++&..0,),,+$$+.01.62./3/-4,)*0465-402.4/4*41..*,1544*(%-3.+-*,.30*00341,.4.,50513/.35).*1-+.*(024&+1/-)+)'/. @rCer/242/1998_57_CCS ATGGGGAAGTGAAGGTGGAAGCGGCAGCGGCTGCAGCAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + KJKKJ4E)HFEKHJIEIAA+F;@@CBD>G?E>@C1IECBIJJ>CG@KKJGCJHGE=HJGGJ?HKGEI?HDCIH:CF,;JKFBGHDFG?HKKDJHJJK=BA?GBJHJHIBKKK@FIIKJHC9EDD>JGIABDE=HEDKHE@AAA@GE:IDJHJEG3JHEBA=?KF@IIHAECG=KK>GGJFGHDBBK@DJEHJDJG/@JK>HFFKGHBC)I0KICEB=EH?JHKKEKKKJJICEIIIG?CEKBFKJCEHJH6IFGKCBK=G=9IGIIIBEFGJKKIFAKHHACFDJDHA>JKH2HIDD><59/8:6<&@?@:27&5,9====D;>EH5=;7<68E9:=<;A99BAEE7;9=EA?B?D:A3=/A>ACBAB@@9>8:<CA;A?:@8>>:>;>@?3C?@9A?DB/B9>5:@=G?DFGB>DEEE@65?GBDIFBEAB;32:<>:?C>>ED;54FA>H=>5;4>>=EEA@D9=CEB=/@<8GFBE=DD?>6>DFIFA@DDDFCF@GIGFHHGIGFGACFFD?D8?2=CB;5A<>GD;D8FDBHACDIE?DAHH>GGC@JFAG3><;GG.GD?6@3IEDG@B@(79B?0<<1AIEB6@@47@?;DDC@:=GFC@FHBG@DDIHB9>E>/I8?=,?A%?7HEG8?FF=AE?IECJBBCE@FGIA@HB9;?8AEA??43H=H@DB>E/BF=:AAD5-7>BA9?DEAD264;0$>=?+F;><>@:;=92?:@FC<@A6@=96AE9>83494DF<4><1?6;96CC4>I2@@?=>>A8=?<>>4&9;49?6HAIE:==>E>08@A/27=DB=78=-A8D;<:E@B@H@@JGEA5A=F5A:9>&.;;CC::;=BFGFBH5F>DFC<88DD7BDHIFGHEAC<==F<9B=DHD=E=CA0B:A>=6B8<H;7G>F@@C/DGIF>FDA&ECD8JHJ@=>=GG??>@:EIG6DA6;C(@G?EF8I;:5GHGDFE>>IIIJCCEED=CB?=;9@@8>5?70E?7>6?;>?D@=8><9,7@@H5>F@8;E>EE9>09FIFG>:C=BEC6=3;/:;37??CABFC<>2H>BE2DCF@D>=FD8HHBEAJFGD@862G451EIDG?FIHFC;G?E@9E8@BFF=:4GE?;A/@E?FGI0CFFC@?A+>B5?DEFGBBC?E5;@DFCCB?67AEBD@8D?>?>>;?;53BG?FBFF?B>EEFEC?E>?CCA;=B2C@C;9=7?>FEBDE@9E??;=/>>9;><==>?=89:>;:7:2(:929:997742,1724=;>8;>89871<689>7==>/;);616+4325<>::<<.0-0-:71;94710-62:5/:+2.65.672/7*178>4=;18718;<9;=/789:3;6=15;.18.<9,*0/7890=97/3;39<(;::::3989;79:767623:799672<85=<7<:8:2<=9=97=<575;4624;.769:9;57:7:<>8<3;7:9414999/61<>0:44890;<>9:=9>=15&73,;9<99258827:338<;>A3;=;>6:279=<:0/9097;:<9;=5=??:440::;?>>26<5<72943:87646:898=:?==:>9>;0>95=77<=27549(5,23:1:649+56-3;+*15/003-9+8:(=59871.1=;<,<-0:1.4160;9=;<3)63:==5;4;>=>>=>8=>=:<9?==:7680752:>:/=.;:89<.<<;)4)356:97;==09:><9>98<39<87<8-$89:9258;6;5/=,<8958>>6;7*5;=:;>/<95=:4?>99267>887$<2888<9<*3/-83/)3435:1121:9:9;;:44(&55:8.6078573:360.40226,68858::4666:8;9;689:2647:;:49860:9:80+298826(5-054/5:859867-4987899*42559848-43+24,4,2184931622;966:47::755&21275*776:://45298'/8;:6598195*.8::98999/,8541768487(,66;75-787875842;+3872:-678:3;8:74;;2756461-04-::8*9994625882289156/88:896:183929/98::2::9:/8273::5995;9398257::366:464;;8/-238*852:99-84,85;6:815:99931378958:8466798<0>5;=:84;/=;:;4;;5,:28;86=7>);:8:5:<7673<<><>88>66&(..08:096/5%*.:;=>8=8====7::960'99569;:?,::=;9??4;958;5<6==<=>7;.==635;:7<;=>>=9=>?=:;2;;=4?>;:3<347>8;39;<>:;9;8>;2===:=?3-85.7;;<26<.689=?;=<9?8<7=984518<=<99?8=2:8=7::?:7-:>>214,<>=>=:<;?>;=8:45=9?=?=?:<835<9;<>6<<::<==<7=65653;=:><;7>=9=>5<::898?>;;:<6:99=3793298=;98799=9?26<4:51=<;:9.47<5?<36:9==*7821:-9=;==>:<><7<:?818=0;/<64<>7;<729:5:?<=><=9;:6299;7<9:76;574-#;880.775/-5;6>/&25 @rCer/245/25_1432_CCS ATGGGGCTGTTCGCCTGCGTCGCTCCGGGAGCTGCCGACGGACGGAGCGCCCCCGCCCCGCCCGGCCGCCCGCCGCCGCCGCCATGCCCTTCTCCAACAGCCACAACGCGCTGAAGCTGCGCTTCCCCGCCGAGGACGAGTTCCCGGACCTGAGCGCCCACAACAACCACATGGCCAAGGTGCTGACCCCGAGCTGTACGCGGAGCTGCGCGCCAAGAGCACGCCGAGCGGCTTCACGCTGGACGACGTCATCCAGACAGGCGTGGACAACCCGGGCCACCCGTACATCATGACCGTGGGCTGCGTGGCGGGCGACGAGGAGTCCTACGACGTGTTCAAGGATCTCTTCGACCCATCATCGAGGACCGGCACGGCGGCTACAAGCCCAGCGATGAGCACAAGACCGACCTCACCCCGACAACCTGCAGGGCGGCGACGACCTGGACCCCAACTACGTGCTGAGCTCGCGGGTGCGCACGGGCCGCAGCATCCGCGGCTTCTGCCTGCCCCGCACTGCAGCGCGGGGAGCGCCGCGCCATCGAGAAGCTCGCGGTGGAAGCCCTGTCAGCCTGGACGGCGACCTGGCGGCCGGTACTACGCGCTCAAGAGCATGACGGAGGCGGAGCAGCAGCAGCTCATCGACGACCACTTCCTCTTCGACAAGCCCGTGTCACCTCTGCTGCTGGCCTCGGCATGGCCGCGACTGGCCCGACGCCCGCGGTATCTGGCACAATGACAATAAGACCTTCCTGGTGTGGGTCAACGAGGAGGATCACCTGCGGGTCATCTCCATGCAGAAGGGGGCAACATGAAGGAGGTGTTCACCCGCTTCTGCACCGGCCTCACCCAGATTGAAACTCTCTTCAAGTCTAAGAACTATGAGTTCATGTGGAACCCTCACCTGGGCTACATCCTCACCTGCCATCCAACCTGGGCACAGGGCTGCGGGCAGGAGTGCACATCAAGCTGCCCACCTGGGCAAGCATGAAAGTTCTCGGAGGTGCTTAAGCGGCTACGACTTCAGAAGCGAGGCACAGGCGGTGTGGACACGGCTGCAGTGGGCGGGGTCTTCGACGTCTCCAACGCTGACCGCCTGGGCTTCTCGGAGGTGGAGCTGGTGCAGATGGTGGTGGACGGAGTGAAGCTGCTCATCGAGATGGAGCAGCGGCTGGAGCAGGGCCAGGCCATCGACGACCTCATGCCTGCCCAGAAGTGAAGCCCGGCCCACACCCGACACCAGCCCTGCTGCTTCCTAACTTATTGCCTGGCAGTGCCACCATGCACCCTGATGTTCGCCGCCTGGCGAGCCCTTAGCCTTGCTGTAGAGACTTCGTCACCCTTGGTAGAGTTTATTTTTTTGATGGCTAAGATACTGCTGATGCTGAAATAAACTAGGGTTTTGGCCTG + 49%>9=9<81772+67.3=:455;;2326;898<9A=<25>@@8?6,26(47488-?9:=.=93<0;<.><8.>=:>=8>53B=;>+B<4A@=0=<:<=B8C><761=B:D?;?CA<3=%;=;=90ABB@?5@%<;A<5=83;:;=<25'=8D@CA@;8@AE4$69<;==:>9>?B?CB84A>@D3;?AE:=E66:32>-:<9@=D98BH:=E3DE3HE?G?6A?=;A<@E;B-GC?2IFFH8;FD2FD/E:>EFF=G;H>5<9BA>F>;-:FECF9@6@?9@0<89=*75;9=>24?>:C?;F+DC97;<@79?9EFEE@.ECG<7=84AC?593:A?B9:1/6;;4%(38?>@@29/9;>B?(@BF4AAB@CGCAEEDDD8?A5+684@;=5FF?=?>5D:9A3G;3<>B1@<.?C36B=9E?.13:BD1C?7A>+<=A=<%3<9;@=9:3=<:)29.AA;149<38?BD?F>=<;>5<6B@7@A+:;D7G4;811D8987@E<@?>4AA>E,GCA:=7D>=:;B@7?;*@??C>7C=;AFDDF@B7?AIHF8JA6BH7:K>J9H4BHK7KK4FFHII=IEEGGHJBC>:0KA:BE=5@?8;A8B@GI%KKFC7:2DC6GDB1JJKJ5HKJIAJJJ?JH@FJHJI'CDCEKIKEJJKEJGDDD;DKJCAEEJD@>@HH@@3CE?CIJI+HK:KDDKCKEIGJBH<@GKHDCIFCKK?+KJEI@KKKJ?KF*7J:K.JIKIKKI+KIEFKKK<=GKJHDKJGII+DIHDJC@EFH>8FH@6JKKJB&IC;KHK;D1CII @rCer/247/1486_71_CCS TCCAGCCAGGAGGGGTAATGCTGCAAGCCTCTTTGCCCTAGCATGGATGGCTGCCCGGGGGTGGCTCCCCAACCACTATCCATTATTCCGGCCATGTCCGGATCCCACCTCCACCATGTCTTGACTTCCCTCCCCCCAGCCCTCGTAGGATTCTCTCTGGCATGGAGGGCTACTCTGTGTTCGCATACCAAGCAGCAGCCACAGTGGCTCAGACTTCCCCGATTTGGAAACTCAAAGAGCTTACTTGCCATCTTCAGTTTCAGACTTTCCATCTCAGTCTCTATGACTTATAAGCCAGTTATGAGGTAGGGAGGGACTCATGTTCTTACCCGCCCCTTTCGCCTTGCACCCGCACATACCTATACTCTCTTTCCCATACCATCCAATTCCCACAGGCCCGTCATTTATCACGGGTTAAGCCTCCACCTATGGCTCGCACCTTACTAGAATTGCTGCGATCCCTCTCCCCCTTACAGTAACCTTCACCTATACATAGAAGGACAAGTTCGCAACTTTTGTCTCAGTTAGCTTCTTATGCTTGAAAACCCACTCCCTGGATTTATATAAGGCTTTCTCACCTCGCTAACAGAAGTCATATGTTTGTCAGTAGATGCTTTATATCTCCCCCCCTCACTTTTCCTCTCCCTCCCCCCCCGGCCTTTAAGCCTTGAAGTTGCCAATGATCACAAGAGCAAAAGACGTTTTTGTTCCAGGAATACATTGACTCTGTTTCTGCCTGCCTTTGTTTAACGCTCTTAGAGACAATTAGTGTCCTTGTAATCTTATATTTTTCATTCGTTGACTATATTTACTCTCTTTCGCGCCAGAAGGGCTATTGCTGCGCGCTCCGTCCGGGGGTGATCTCTGCGCTGTGGTATGAGAGAGGGCACCTGGGGAGACTGGTTGGGACCCGGACCGTTGGGAGCCTCTGGCGACTACGCAGCTGCCCTGTGCTCTTGCTTTCGTCTCCCGACACTTTTCTCGCCTTTGCCCCGGCCACCGGGCGTTCCCGTGTTTCCGGCCCTCTGGGGTCGACGCCCCTGTTGAAGAGTTGTTTCAGCTGTGTTCTTTGCGTTGTATGGGGATATCTTTTGCATATTTTCAGAGCTCTGCCTTTTTTTCCGATCTGAGATCCTGATCGCACTAATGTTGCTGGGTTTGTCGCGTAGAGTGTTGCAGGTGCAGGTGGAAAAAGCGGAACTCGAGCACTTTTGCTCTCGCTGGGACGTATGATGATTAAGTTCTCTCTTTTGTTTTTTTTATACGTGCGAGCGCCCGCAGCGGCGCGGCCTAGGACTCGGACTAGGAGTGACTCTTGCATTTAGCGGGTGTGGAGTTCTATCACGTTATTGTGAATCTCTTTTTTTAATTAAAAATACATACCCCATGGCAAGATTTAATATGAGGGAGAAAGG + .,-//+--,).)###-++".&.--,-/,././'*.'-,.././//+""-*///+-,.+(*)./+.%)**+,-++,.+%-#+$(*..).--(,..//.--.,&.-+*",,.,+%(',/..&.$.../%-%&*#('&'*-.&)+-,*(,&,--(-*))++'"**($,%++).-...--,&($)+-+,',-&+(/,*/').,-...(./,.*//../-$-+*,.'#+%.%.(*&..-&.+/()-%.(-$.+&&*.*)---.&%.//.,/&+-*//...//,+,"-,///,/&)+.$/,-//,$-".*-+-..)$+-%#.-/-//++#..(-,+(&)&&%&#)++$--$/,.-(%.-.&..-%++.---+,---(&**$,-+-+,.-,"-+)(*',...)(+(#')++#"#+*--(+).$-'('-.''.(-&,*.'.-**+-,-'$+,-),-)&%-(%',---***,*-)''(),$--.#.*++'*#---,--#-.-,*-,*-'-')+.-#,-,,+'*')),,%'',()#----(--(,),,)&-,'(%&$*---+++--+-,#)+**&*$-'+&"#$'#)##&%&%$'**...&.-%.,)-"%$+%)-//.-/.&/..$+",,.--#('&&&(,%$+,&((&'#**&&$#&&#%&%&+.%$%&%$.-/,&/)..,//*/+..*%#-/(....///-.%,+.*-*)$%)%)'',+,+&#)%*#'&)(,(,'*&%#$$)+&&$##%*$%--%)*'&,$#%&&$,(+''(%-%+*'+)%*-'))*$-++$,&+-&)'%(+&((,-$-($-%*+,(',+&,-,,(+*-(*$*--+"+&'()*&%*()+%(*(&,'$-,+(,%))',-#-,--..(-(+&(+&&###'&*&)#*%*'($$+'#%+(),#.*,#-)#())'-',,&-$&-#&%+&&%--.*,-'$,#,,))---+&(&-,+*+(&&%-*-)+.,..-'(*$+$((*$$$'(&+$)*'),#%#$,$###&$-*%%./)'*'-*.-$+('-)&$#+#')%$#%&,&&,#"#',,*$-'&.",.(.-&')#.'+'.-%),-%).%,+#-#".-(&$*.#,&&+()'&'%&&)#%())++%#(*-%(,&&##$&%)--.#,.'%),'$)-+(',(#'+%&-*-'-(-'-%-'+-'(-'.-)-"*-,-#.&#,)&,(,*&&("*'$%*.+-),)'**-)-)+(-'*),'%$&),)+-*%+,--",.(*.*-',%*-'')$('('%),*$"#($'),',)(--'---).%&&,)--),&),'+)%&,,,(,%*',(,+--,((-,--"--.(.#'''&&+&(%',,(,%)--'%,%'&&(,*')(#-,-#%-$'$#,('$''&'-%)$#%'.)$).'%%%#&*-%&%(+&(#,*++,.+)'$#(,,$&+$ @rCer/248/24_2033_CCS ATGGGGAGCCGAGCTGGGGCGCAGAGCGCGGGAGGCGGCGGCGGCGCGGAGCCCAGGTGGCTCCGCTGCCGGATGGAGTGTCCCAGTGTGCTGATGAAGCGGCGCATGCACCATGTCATCATGTGTCTCTAGTCAGCCCAGCAGCAACCGGGCCGCCCCCCAGGATGAGCTGCGGGGCAGGGCAGCAGCAGCAGCCAAGCCAGAAACCCTGTGAGGCCCTGCGGGGCCTGTCATCCTTGAGCATTCACCTGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACCTTGGCTTGGCCCGGGACCGGCCCTGGAGGCCGATGGCCAAGAGGTCCCCTCGACACCTCCGGGTCCCAGGCCCGACCCCACCTCTCCGGTCGCAAGCTTTCTCTGCAAGCGGTCCCAGGGTGGACTGGCAGCCGGAGGCAGCCTGGACATGAACGGACGCTGCATCTGCCATCCCTGCCCTACTCGCCCGTCGGCTCCCCTCAGTCCTCGCTCGGCTGCCCCGGCGGCCGACAGTGGAGTCTCACCATGTCTCCATCACGGTATGCAGGACTGTGTGCAGCTGAATCAGTATACCTGAAGGATGAAATTGGAAAAGGGCTCATATGGTGTCGTCAAGTTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAGAAGCTGATCCGGCAGGCCGGCTTTCCACGCCGCCCCCCACCCGAGGCACCCGGCCAGCTCCTGGAGGCTGCATCCAGCCAGGGCCCCATTGAGCAGGTGTACCAGGAAATCGCCATCCTCAAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCAACGAGGACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACCCTCAACCGCTCTCTGAAGACCAGGCCGTTTCTACTTCAGGATCTGATCAAAGGCATCGAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTCGGAGAAGATGGGCACATCAAGATTGCTGACTTCGGTGTGAGCAATGAGTCAAGGGCAGTGATGCTCTCCTCTCCAACACCGTGGGCACACCCGCCTCATGGCGCCCGAGTCGCTCTCCGAGACTCGCAAGATCTTCTCTGGGAAGGCCTGGATGTTTGGGCCATGGGCGTGACACTATACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGATGAGCGGATCATGTGTTTACACAGTAAGATCAAGAGTCAGGCCCTGAATTTCCAGACCAGCCTGACATAGCTGAGGACTTGAAGGACCTGATCACTCGTATGCTGGACAAGAACCCTGAGTCGAGGATCGTGGTGCCGGAAATCAAGCTGCACCCCTGGGTCACGAGGCACGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAACTGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATCCCAGCCTGGCGACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTCGAGGGCAGCCGGCGGGAGGAGCGTTCCCTGTCAGCGCCTGGAAACCTGCTCACCAAAAAACCAACAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCTCCAGGGCACCGACCCGCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCCTGCGTGGAAAGATGCGGGCCCCGCCCCCGGCTCCCCGCACGCATGCATCCACCGCGGCAGGAGGAGGCGATGGAGCCCGAGTAGCTGCCTGGATCGCTCGACCTCGCATGCGCGCCGCATCGCCTCTTGGGGGCTGCTGCACCGCGTTTCCATAGCAGCATGTCCTACGGAAACCCAGCACGTGTGTAGAGCCTCGATCGTCATCTCTGGTTATCTGTTTTTTCCTTTGTTGTTTTAAAGGG + /,$.,-.0055,551*/--,1*13220130440'13/53+30,4555).1('101)2,'3.11354'((0+)$.'0.0.+-$*-...-223/$&$)+/-*$56665322-/566:53,,,.67.%+,)(,-+')'%(1+)%*#'%*5(1&00084"-/12/(,8845866233./7211*13/2/3/97-(25567&43.:92'83277566443335/-55'.50&*3.2./838,-23,(/4463899+:6461:0+3,3(302-06239+.-,0+,&-*-$,+*-$23816::9124-2.132710%,42:-:5'.../.()&8679;5+8$47.1+8'--431-3+%14113.**)&---2(488,864&22::86'8648.0-.---%+-3558;:8)/-4,2595%+#)+22-69-.3433777806522+2.35/:756636.41-22936565499229945468%3*'/66.3/5+201327%/582299/,*363040/103..2#,.).155.473.-2/4+528865,*3.445962'3,,171'(7::687%5,50-3226384)+*503884401543/),.+.&201-1-.,-(,-1)565&1/004:33-1.*)-66546/1:3;7*;&;6>3=>:?6,09:9471=0:+2-.7=;068482>=3.85>-7;+;:22&<888-7871<>=2<47-+-824286/6749)65,22&20+,/3(622:/,,1./6-28<8332*793;225::>;79,:45&>6(<8+238;9>9;97;1.%',3*0258/:;9=>3:87(9,0(;)49:;94:6472-658269;7/<:0+/053$413;9:=<3?99<9<>8%854><;:2:6728:3-3012620381,-./4.529(324*4*$.,6872+*1/0*05(63206-11)-*5548-/5/4.77536826'-3+3,1021-+&)7:65(,5625&581:.524:8,32+0(.30/43/211(22.0/2024,4:72126331)02'('8,5)32:4453,236242-&42,2%45736445195,(466-0.,'*2++1.+,&.9.40836&612,5783-.,057/+2/..0-3,4//(**165/95.--*.8:90,$/132853%2-1432,2-013*-21)*23-5716222855350+',.1208,-&)2775365+48344846713839993.*),%134+0/091(01353:63.5$1416423+-4018.04578:65,.7/)500)-2/+((30(+0'.6070453:*2.*'15/9845213569--527-2+034,30+*19579:092631457)7635162/(+,-,-32-/+017/2*&0+43./0,044761//74-919-5585)/2336*/05154-511+473-%/,-3,87463484022)25.34/5/58879:755-6/5442,'524;2952560766787767/4.-635579365/34469386.2/+$/17../95534--/2(5822*-0,103/88=+:/2*-/7652$2:9>94'6.381==1956762-06/':;8325;386)=;7)486=1.7/88587831785256:-:<72)54=<JHJHFGKKKKJIJJAAE<@EKJJKCJJGKKIJIJKG2JKJ5KH>KKKKHJFFJJKB1KCIJEKKKKI8KKKJKJKHHJKKKKJIKKKKJI;KKKIKKJGJKJHIIBKGJ>KKKKGGJJHK=DC?JEH?KIBJAKKI>FKKKKKKHIIJEIHKGKKKBKIGDKKKKKKKKCKK;KKKKKKKKIFC2AKJKKKKKF?KHIE;HHKKKJJK8K;GEEGKK=KKKKIKKKKKICKKKJIHKKJGE:JI6JH=@JHK.GDBDKFIDICCGJJAKKK7KKGE@JJKJIFKKEJJKKEK=GHIKE2G9FIKKJKKKJKGKHKKKJJDJGD>JK:KKCJK=CI>GJKIFCIIKIDHIIKKKKKK<=FKHKFKE@DHKKHKKKK>JKKEEKKDKKKKKKKAKKJKKKKJJGAG6GCIKJIFJKJJIFIKH8@5DKKKKKKJKKKKCIJKKKKKIKEKDKKIKKKKKJKKJF>GGKKJIIKKJIIKCIGEJIFKJIGK=JKKKKJKKJKKKKGKJKK@JIGCJKHKHKKJKJKKCFCKJKKKKAKJIIJE?HBCKIJKCHFK>JGKJDKGJG?D=K?KK;GFKIKEJJHDKKKHHCJF9JKFKK*JIGJB99?EECKEKJKJKJKKHKKJKKCKKIIKKGKKADFKFK'KIKKKKHBKKKJIK?JKEK9KKKFJIKJHIHFC:KKJAAGHI>GJI/KIKH>KEJHKJJGIBAK2FKKCJKKDGJKK8>DJKJHJJGBJFJIJKBKKHHK=KKCCKBF;FHEBEKBH9FH1KGCHEBHEH9>C=I>GKHADJEGHE4GJGIAIFFB5?B>JEHHHK>ABAI>GABH:E4EGIH,;AEDFB,BGH9@DIF@E>=A:'?3?3A:D6>A8@@@C=+ABE?E>A:=%F?A:<;<<24CE?GHFCDDD<%??HIK-GEEHJGF4H@BBJFHFBJ3H?ACD@@<>@99=042FAGHJ=GAHJIDIFGGGID*GE=@D'DIH?HGIKGGFDC>@E @rCer/252/1943_63_CCS ATGGGCCCCTCCCTCCCCAGCCTTCCCCGCGAGCGGACGCGGCAGCGCCTCTGTCTCGCTTTTCTTATTTTTTCCCCCTTTCCCCTTTCTTTTTTTTTTTTTTTTTCTTTTCTTTTCCCCCTCCCCCCTTTCACCATTTCCTCTCGGAGGCGCTTCCCCGGGCAGGGCAGAGCCGGTCTCACCCCCCGCCTCTCCCGGCCCCCGCCGCCTATGGCTAGAGGAGCCCCCTCCCCACCCAAGCTCGAGCGGCGGCGGCCTCAGGCCGGGGGTCATCATGGAACTAATTCGCTGACCGACCCAGCACCCGCAGCCGTGCGTCCCGCTCGAGCGCCAGCGCCGGCGCCCCCGACCGCTTCCCCTCTTCTCCCTCCTCAATCGGCCCGTAGTCCCGCGCGCACCGCCGCCGCGCGCCGATGAGAATGAGGTGGTAACGGGCCCCGGATGACCCGCGTCACCACTGTGAGGCCTACAGCTCAGCCGGGGAGAGGAGGAGGAGGAAGAGGAGGAGAAGGTAGCTACATCAAGCTGGCTAGCAGGCAGATCCAAAGGATATCATGAAGTTTCCAGGGCCTTTGGAAAACCAGAGATTGTCTTTCCTGTTGGAAAAGGCAATCACTAGGGAAGCGCAGATGTGGAAAGTGAATGTGCGGAAAATGCCTTCAAATCAGAATGTTTCTCCATCCCAGAGAGATGAAGTAATTCAATGGCTGGCCAAACTCAAGTACCAATTCAACCTTTACCCAGAAACATTTGCTCTGGCTAGCAGTCTTTTGGACAGGTTTTTAGCTACCGTAAAGGCTCATCCAAAATACTTGAGTTGTATTGCAATCAGCTGTTTTTTCCTAGCTGCCAAGACTGTTGAGGAAGATGAGAGAATTCCAGTACTAAAGGTATTGGCAAGAGACAGTTTCTGTGGATGTTCCTCATCTGAAATTTTGAGAATGGAGAGAATTATTCTGGATAAGTTGAATTGGGATCTTCACACAGCCACACCATTGGATTTCTTCATATTTTCCATGCTATTGCGGTATCAACTAGGCCTCAGTTACTTTTCAGTTTGCCCAAATTGAGCCCATCTCAACATTTGGCAGTCCTTACCAAGCAACTACTTCACTGTATGGCCTGCAACCAACTTCTGCAATTCAGAGGATCCATGCTTGCTCTGGCCATGGTTAGTCTGGAAATGGAGAAACTTATTCCTAATTGGCTTTCTCTTACAATTGAACTGCTTCAGAAAGCACAGATGGATAGCTCCCAGTTGATCCACTGTCGGGAGCTTGTGGCACATCACCTTTCTACTCTGCAGTCTTCCCTGCCTCTAAATTCCGTTTATGTCTACCGTCCCCTCAAGCACACCCTGGTGACCTGTGACAAAGGAGTGTTCAGATTACATCCCTCCTCTGTCCCAGGCCCAGACTTCTCCAAGGACAACAGCAAGCCAGAAGTGCCAGTCAGAGGTACAGCAGCCTTTTACCATCATCTCCCAGCTGCCAGTGGGTGCAAGCAGACCTCTGCTAAACGCAAAGTAGAGGAAATGGAAGTGGATGACTTCTATGATGGAATCAAACGGCTCTATAATGAAGATAATGTCTCAGAAAATGTGGGTTCTGTGTGTGGCACTGATTATCAAGACAAGAGGGACATGCTTCCCCTTGTCCACCTTTGCAGCTGTTTCTGTCATGTAGTTTCAACAAGTGTTACCTTTGAGTGTAAACTAAGGTAGACTACTCTGGAATGAGACATGCAAAATCAGGAAAGGCTGTAGAAGGATATATACCTTAACAGGCTGATTTGGAGTGAGCCAGAAAAAAAAAAAAAAAAAAAAAAACTACTCTCATTATTTGTGTGGCTAATTATAATTCAGTGTTATTTAAACACAT + >9DA>?=;DDAC6C8B:,7AFFFFEFFDECBBBD?'@ABB?@&@C>?90:@.?:;<+;=>;=3*D=C?A<>BDECC&;<68519<'1276=?$:?903$77@;;:295>B+<5:AA=-4>0D;B@A@4CF==B:B=?AA?@A4AD@B2BACFB3@7BE:,7?5FCD.CDB:>>3D:<<9C>-;@>.3DBGC?<6%CB=%:5:DD=B9%:?@>:=BBBA>;<8ED88.@DDA?A>>2;?99@7$0&08'8;.=505-+;+96A:7A:>-<568355:06:.3BD7=?+@9BB?:@5?;@>>8-=A4D7@C>B6BBB2<6C@BB>C;9?8BA5FCFAB*D>;74@5@GDF?B>5=;C3@@D?>=E?CAFAGF?7>=@:DBCG?BE>2AF@D=AD7?97F=FBEGBF8?::'B2ED=CBCCB?,CA=A8E=GDEG>EB2EC@AD8CAD5A>?A?@$=>DDAE@E6@E?FCC@??@DB.A?BF@>9.=3C5-CD=BFE?E@AB;@>@A=0:@@1>@>D@E9;>,;<:;?>>EF7@DF0AA??@@??B<9:C;D;9=9=6C69BB6DC56CAD9@8115=E:AD<>@=FCB?=:A9B=4C96@CAB0=@@C6E;=A@@><;:CBA)AFA=GG=B4@C@=6>C1<.@>==>1?77=;69.@@C:86<>AA7>??9274;?>A:A4@B6@6@??3@??;:>>C:@<;:>.A??>@=-B9;783A1::::05%>C::?7=@??59@9:@9>38=-<87<=;;295972>;6<;712<;>?:63:>@@A8<C=>;@@5/3<<9>==>7=9><:<9>;=:B=A5:19@?4:7#:?<:?<><>>B3<;A;@<7==@13.B<=979?;@AA,?@5C<9==;8A232=6B0719897918<<9::9637)6;6<*3:038<9<8.=?>=;<8=898806<8><:78.0/<&=5<33=6;=>:9773;<49=7-897745>>9>>*1589?85/14.=:;=4==4:4===5477<<=;;7=261110=17078';:68'789:3)'6>79:==7=9861448<::53;<<=/83:4860089?;9.<5=79&/535*=:2=72:6<8-1+242;7689'7.030)77235)6881(5:8927<<0105:8257417?66849:55/53002+**414323&+22/51243977110859'3.2734'./0/30:6&;>>=7=:04/3971450(:163979171+:751::;)778;;?9?54;:><4<.8:77<<;:8:<:9:;<;;;:8846$;7:<;9-5386=8;26,6>=;>>;>?836:;:7>;:-881;>?56<5,390? @rCer/253/0_862_CCS GCAGTAGACGAGCAGCTCGGCCCCAACCACCCTGGAACAGTTACAGAAACTTTCTCCAGTATTCAAGAAAGATGGAACTGTCACTGCAGGGAATGCATCGGGGATAGCGATGGTGCTGGAGCTGTTATTATAGTAAGATGCTGTTAAGAAAGCATAACTTCACACCACTCGGCAAGATTGTGGGCTACTTTGTATCTGGATGTGATCCCTCTATCATGGGTATTGGTCCTGTCCCTGCTATCAGTGGAGCACTGAAGAAAGCAGGACTGAGTCTTAAGGACAATGGATTTGGTAGAGGTCATTGAAGCTTTTGCTCCCCAGTACTTGGCTGTTGAGAAGAGTTTGGATCTTGACATAAGTAAAACCAATGTGAATGGAGGAGCCATTGCTTTGGGTCACCCACTGGAGGAATCTGGATCAAGAATTACTGCACACCTGGTTCATGAATTAAGACGTCGAGGTGGAAAAATATGCCATTGGATCAGCTTGCATTGGAGGCGGCCAAGGTATTTGCTGTCATCATTCAGAGCACAGCCTGAAGAGACCAGTGAGCTCACTGTGACCCACTCTTACTCTGCTGGCCAGGCCACAGTAAAACAAGTGACCTTCAGAGCAGCTGCCACAACTGGCCATGCCCTGCCATTGAAACAGCGATTGCATTTGATCAAGCCATGGTGACACAAAATACACTTGATCATCAATAGGAGCCCATGCTAGAAGTACATTCTCTCAGATTTGTACCAGTGAAATATGATTTCTGAACTAAAGAAGACATTAAAAGAAATTGTATTCTTGCCAAGTAACCACCACTTCTGCCTAGGTAATATGATTATAAGGAAATCAAATAAATGTTGCCTTAACT + S$&#%,($#()+,'$*#&%%%,*,$'(),,*,)',#&&$*)-+*,---*-%$!##(-+-))%&&&()%)+')'),**,,(+)),(((++..-.,-)&+-(()%&),($#*,$&%''&%''*&*,&.+'""#%#%"')((,(00-1'+)#%))+/0(/*..++',(''*("$+&%*))#$/)(,/(--1,++'++-0/,/,11./+/+1-,1/(*#(+(,,/*+.))&#(.---20/)101.*,-./2.,,-,&'$,,..0/,&))-&&,+..-)&%%(,01(/+(,.$*&*-,,15'1/($$')%+16*44654-&--+(+)16%*.;569011/0/:6944<=::776139:821(20,&+01284695767<628799/4-533577)53/47351&$'222*/1(3%,5:48:-7>683('/6;:<69<::516242:16)0174:48<:,=.54:50*),#-0-'&'$(&(1454:/9:2<1,/05,687:86;32>3:/73874'425<-(*.437138457502-.&02499-9916477<921458<009;,5*,555-/3-*,/12-'14((2293+')51)-47-5//2-00243020662+++2163.'(.)/%*146122()**+1/4-$'(./)1-/).23125.26.654203*5,,32-260/.,/,%//3++12#&433,,+.#%443+-&6'113-335..+5-.02305602+4346&5.*03)-8:03(4/--065*:98692154(9991:+<>7**%244::><-956=3:6<=;:?9@=88?5:2)91;8553315'68==:>54.,*33-8)7868?=59,:85(42361958;238?53 @rCer/255/24_2327_CCS TGGTGTAATTCAGCAGACCTTCACTGGGCACCTGTGATGGGCCAGGCCCTGTGCCAGCAACAGGGAAGGGAGATGAACAAGGCACGTTTCCTGACCATGAGGAGCTCTTGGCCTGTCCCTTTTGCAGTGTTGGGAGCTGTGCACAAGCAGTCAGGACTTTGGGACAGAAGTTTAGTTTAGGGAGCAGGATAACTGCTTTGACAGCTACCCACCCTAAGTCAGATGACAGGTGTAATTCTGGAGGCCCTGACAAGTATCACTGAGGCAGGCCGAGGAGCTCTCCAGGGAAGTGGGCATGTTCCCTGAATCTTCCTCACTTCTAATCAAGGCTGACTCAGTTCACTTACGGAATGAAAGCCAGTCACCCTGCCACTGGCAGAAATAACATGGTGACAGTCGAGATTCAGAGAAAATAAGACAGAAGCAGTCCTTTTGTAAACCCTGACCCAATGTATGCCTACGTCTATCATACTCACCTCTGATGTCTTGACACGTCTGGGAAGGCCTTCTCCAGCTTCCTGGAGCCCACCCTTTAAGCCGTGGGACTCCCTGTGTCTCATCCATGGGAAGTTCCAAGAAGCCCAGCATGGCCATCAGTGGGACTTCAGGTAGACTTTGTCCTGTAGCCCCCACTTCGCCCTAAGCTCCCCAGCATCCTGTCTACCTGTCTGTGGAGTCCGCCTTTGCTTTTTCCTTGCAGGGAAGAAGGTCCCCTTTGTGTCACTCACCTCCCCAGGCTCAGAGTCCCAAGGCCCTGGGGTTCCAACTCACTGTGCGTCTCCTCCACACAGACCAGCAGGTCCTCCTGTGCTGACTCCAGGTTGCTTCACACTGGGAGGGTGGTTGGAGCTTCACACACCTAAGGTCTTGTGCTTAACAGTTTAAAGGAAAGTCCTTGTTGAGCAGAACTAAGTTCACAGGGAAAGGTACACACATTCCTCTCTCTTTCTCTGTCTATCTATCTAGTTTCCCCAGCTTGGAGAGCCTTTCCCTTTGCTTCTTTTCTGAGCCACATAAGCTTAGAAGAAAAGTCCTAAACCAAGAATACGGTCCTTGGCCACAAAACAGGGCCTGATCCCCCATCAGAGCTATCTGAGCCTGCCTGCCTGGGCACCTGCTGCAACCATGCAGCTACCCTGCCAGGGCGCTCACCACACAGAACCGCAGGGCCCAGGAGGCATTCCACACAGGCACTGGCCCCAGGCGATAGCCACAAGAAGCCTAGAGCAGGAAGCAGAAGGAAATGCTAACGAGATCACACACAGCTTCATGGTGGGTGCGGTGGGGGTGGCTGGGCTCTCCCAGGACAGAGGGGACTCTGAGGTTGGCAAGGCTCTCCCCACTCAGCCTCATGGTCCCTTATCTCCTATTTTACACTATTTCCCTCTTGAGAAAATACGTGCTTTCCGGATGTATTAGAAATGCATGAGCTCACCGAGTCTACAATAAAGTTTGAAATTTAACTGCAAGGAATTAGAAGCATATTTGCAATCATTGCAGCTTCTTCTTTCTTCTGCTCATAAAAGGAGGGAACACTAGATAGAGGGCAAATATATCTGAAAACCTAATTTCTTTCTTTTTTGATAAGGAAAATCTTTTCCCATCTCCATCCATAACATGCATCAACCCGTGAAAGAGATTGTTTCTATAGTAACTGGTCTGCGATCTTTTGTGGCCAAGAGAATAGCAGGCAAGAATTAGGGCCATGACAGAATTTCCACGAAGCTCTGAGAACATGTTTGTTTCGAATGTCTCAGTTCCTCTTTGTCCTCATTGTGTACGATCTGTCCCCATCCTTCACTCCTCCCAAAGCTCACACCAATTTTGGTTGGCACAGGCACGGAGCTGGTCCCCTATTAAGTGGCATTTATGTTAACAAAAAATAGTTCAGAATATCAGCCTTTTTCATTGTGTCATCAAAACAGCTTAAGAGGGGACTACTGCCAATGTCCTCTAGTCTGACCTCCACCCAGGGAGACCCATGCAGCCTTTTTCAACTTTCTGATTCATGGAAATGACCTTGTGCAGCTTTTCCCACCTCCTAAGTGTTTCTGCATCTGTTCCTTCCTTTGGACCTCACAACAAATCCTGTGAAGTAACTGAGACATCTGTTGTTAGACACATTTTTGTGATGAGTAAACTGAGGCTTGGTGATTCTATGTCTTGTTCAGAGTCATTAAATGTATAGACAAGCCCAGACTCCCCAGTTCCACTCCTGGTCAGGATTCTACTTAGGGGTCAGTATGCACCTAACAGACACTGCTGCAAACCTACTATGTGCTAAGCATTCTACCAACGGCTGT + "$&'('$+),*'')*'&))-.,(%'%+'%$&%'*,+,'+-.,*+*,+-.,($+,.--*,.)%$)*',&-,'#%++---+.'-(,-+*-)$)),-(.)')*(-,)++*'*(-')+,'),-$()%*,)*&**-)-,(,)''+,)+((''((*,--*)**).,$,+')(,'+))+++()#+,,-++$)*()()*-"%)+$*((&+,+%),)-,+(+*%',,--,&())%''')&'&'*)-)')+%#%%&+,(&(*-+-,-+)&+,&&-','*&(*'%+()(,,')'%'-,'*)&&-+'%,*$,&)(,-),)-,-+.---,)+)&'+(-,,#'*),-+*,,)--**-,-*--.'-','-,,,(&+',(%*')'#')(($+(),#&)+,.--,%-%%*-,-)-+--,+,*-+*)'-,),+-,+(++)*+)*(++,)+++-,(,-,-,)((&+**)(,,')'',,'#&+-)+'()()(%*+,-)'+,*&&'(&"')),++(*&#*&&('-(*+-+++,-+,+,)-,(-&'(+-,(*+#%#$%%&&((&)*'"##')'*'*(%&,-*,-*)$)+%+)(+&)&(+--('+'$)%+)+,#*)),+('(-++,(',*#+(,)%#(,,))'%-,(+(())))))()($(&)&())(''&))%'&($()%('&$%#%$#%&($%$$%&'&)&')&))(#"&&&)'&$(('($))%'%')&)('($%$%(((&((&&&&&')'%'&''$%%(($&%$$$&%#%#%$)(%%('&%%')()''&)(''&%&(%()()'())))'()'(&'((#&(%')%()''(%$$%''''('$'%%%'(((%((&%%''&$%$%$''&(('('''((('$%%$%('##$&%%$&((()%(%%%"$&#'%#$"((('%$%))())('$#'('&($''"&'$((()&$$&%($&&(&((&')$##&%%''$%%&%&$%"$$%$##%"$#$$%%&#%$%&($'&#'&&'(%(()'()'#'&$$#%$#&'(('%#"#&''%'')(%$%&(&)($('(%(%&&()&%('&)()(&#(,'+,$*'-$%*+$)++*(*..,*),&+%,(*,,)'&*(+,'),--)+)')&)&((($'&%'+++,.-,&++(+-'*(','*(,*(#"$&*(-+%++)+**)*(,$**+)*,-$+,+'$)*)--''+(+.-,)+&-'(*+(),,)'#$%&+*(,),+,,-+-+,*)-.,*)''&&(++*$+)-'*+--+',','-(,-+%'(-+'))+------*'$*'+,+)*.-*-+',)(,+%(&()&)-**#,,(+,,&%-+&,*&%(*%)(+*()*-+-*($(&+*'+)((+'(%),-,,,(&((+)#)('+(,*-)-'%&+)+'*%+)((+*')((,+'++'+(+,,-)++)++')'('#(+*+,-)++(',.(+(,+))-*,--)$&&&'((&(*,+%'#-%#--,%*++$)''*)&*%+-,*-&$$')*'*%,,(+)$#)%'%)-'(,(-,,+-'(-%%)&&)(')+(+*)),+)#&'($&&(,++-),(#)+,'(-+((-+'++)(+'#%&)%+,+)*((+&,--,.-'%)-,+(&('&%&($*'**('+--$(+(+,,('&''(#%&'%%$(#%"%%,+-.---(+(,*$()-+(-,-',,((-)-())*+--,()--+$+(&)'%)(+,,'(*-.-+),&$*)#'&%(&-,,.-(**--*(*+%(&(,(*'(-)-#('))'&*+*-,)(((+,',,+*,-,(('',&$%,&+,,)--,+(&()()--++-(%&)-----)*..,'*.--*+,+)(($*++..+(**%)'((&*#$"$%$"%##&&#&&(&',,-')*+%'$#*($'*",',',&,&#%('(('%''()$(),,*$*,%-,,)(-+&),((&('((-.('*(,(+(-+-,$+*+,,*-,-)-+%"$+)+--++,,,.)-+#()**&#*-+((,-()',.,)*+)$*)($%%''((&'%#$'#$))&%$((%+('&&'(&"$))%#"'(&)'*(,+-,-+-,(+),')'+)--,-'$)()$%**,*(&((-**&'(,+,(-))-'*(%$&%+*(''$(*+,-++#*--+''*'(,,,,,')---)--+-)+*+(++&++%))(&'*&&,))--,,((+-+&)%+++)+-,'&(*)&(.+(-*('(,(+'(+&)+'*&,+)(*)(-+&&%'))++*',+)*+,,+,(+)+*)+$"%(*$%(*(++('+()--*(%""#""$('(,+-,+(&())&$'((**--*,++-*,&$*)$''+++%)-&'(',+*(&,,&&) @rCer/256/1970_54_CCS ATGGGGGCTGCGCTCGTGGCCGGGCCGGGCGGGGAGGCCGGTCCGCGGGCGGGGCAGGGGCGGCTCCGCGCTTCTCCCGCCGCCGCCGCCAAGGGGAGTTTCCAGGAAGTGGCCATATTGGATCCATTCAGCCGCAGCCGCCCGGGCGGAGCGCGTCCCGCAGCCGGCTGGTCCCCGTCGCGGCCCCTGCGCTGGTCCCAGCCCGCCCGCCCGGTGCGGAGCTCGCCATGGCGGCCACCGACCTGGAGCGCTTCTCGAATGCAGAGCCAGAGCCCCGGAGCCTCTCCCTGGGCGGCCATGTGGGTTTTGACAGCCTCCCCGACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGAGACTGGCATTGGCAAATCCACACTGATGAACACGCTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTACGACCTCCAGGAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGAGATCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTTGACTACATCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCATCACGCCCACGGGGCACTCCTGAAGTCCCTGGATCTGGTGACCATGAAGAAACTAGATAGCAAGGTGAACATTATTCCCATCATCGCCAAGGCTGATACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGCGAGCTGGTCAGCAACGGGGTCCAGATCTACCAGTTTCCCACGGATGACGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTCGCCGTAGTGGCAGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCTGGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGCGACTTCGTGAAGCTGCGGAAATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGGCGCTGCAAGTTGGAGGAGATGGGCTTCCAGGACAGTGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATATGAGGCCAAGAGGAAGGAATTCCTGAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAGAAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAACGCCGGGAACTGGAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTGAGGAAGGACAAGGACAAGAAGAAAGCCAGTGGCTGGTCTTCCATTTACAGTGTCACTATTCCCTGATGGAGCTGTTATGTGCCGCTCCAGTGAAGGCCCCAGCCGGGATGCTAGGCCTAATAGTTCAGCGTGGAGATGGCAACTCACGTGGTGCCCTAGGTGCAGCTGCGTGGTCTGGTATACATGCTGCAAAATTCACCCAGTTCCCTCATTTTAATTTTTCTAACCTAGAGCTTAATTTTAATAACTTTAAAACACTTCTAAATATTTATTTTGGCACCAGCATCAAGACAAATAATATCCTCTCCCATTATTTTCATAAGTAACACAGATTTCCTGATTTTAAAAACTAAAAAATACTGCTAAACCTTTCTTATGTATAAAGTATGCCTATCATATACAGGAGAGGTGGGTAATAAACTTCCTGTAATG + CJJFKK-KJKKKKJIK@KDKCKK/K;KK=KKKK9JK/KAK9JK#?IDE4FDHK%JIKKK+KKKFIIJKK$AKEKKKK/KKKKKKKKIKK>K8KKK8GIKKFK4JJDK>KKKJK?JKKKGJKK>KBFIKKJKKI7KKKKKK38JK$KKKI>JK=DKK*KCKK5KJK;KKK3K:=FKKJJIKKJJKEIKKKKKHK>JKDKKJ?IKKIKKKKKGE:KKKH3JKHIIJKAEHIKKKKCKGJIKAKKKKK5IKK&JKKKK)JJJKJKKKKIK=DKKBKKGKJKKKKKKHHI>KGK?KKCKCKJJ3DK5KKKK2KKKGJGKKHIKKJKKKKHKKJKJJHHGH*CK=KKKK1KKJJJKJKJKKHJKKBKIKKKKKKKKIK4KKKBJKKBJKBKK;F9KKKKKKHKKKKKKKKKKEJKKJKJ;GJKKKIKGKKKFKKJJJK3KJKKKKCKKK4GKAGHK?KHKBHK+K9KK=KK/K7KKFKKKKKKK:IHKKIKK5HJKK4GKKK>HJJJKEFFEJKKKKK?GGIK(K9KJFI1HEHK+@J=GJHKI6JIK4KKKIIKKFK@K6KGKGK5KKKF@KKJJKIFIJKJ1J)K=EK%K3K5DJKIKJKHKICKK>KKKK?KJKCKJ>KGHCICJKBGG=AJKKBK5JKK*KCKKDGJJJDK9K7JAIKJEKFHI7HJ?KKIJKKKIEKGKJHEG?K9KKKFIKCJK5F:KJIKIGGJJG$JJKI=K5KCKKJGI>JKKDJK>KKK7KKIKKKKDFIK6DIK0J9BJKDKJ0HIKD@KFH;K=KK2GKIFJDGEKKKK7KKKJJK9I5?J&DGKJKBJ7KKK6B=K-KKBKJKKIIJ@K=KKFKKKJ@HKJKHKKJKCIJKBKKDGJH0KKIK?F@KK(GEK(KIKIJIJKJKJKJJG8KFHGGDKHKKK?KKKKK6K?DKKK7GGA'IK$JKJJJI(K=KKKK0JHH;K0JIKKKJKCKGKKD,I5IKJ @rCer/262/0_1851_CCS TGGGGCTTTTCAGGGCGCTGAGTGGTTTTTCGGATCATGTCTGGTGGCTCCGCGGATTATAACAGAGAACATGGCGGCCCAGAGGGAATGGACCCGTTGGTGTCATCGAGAGCAACTGGAATGAGATTGTTGATAACTTTGATGATATGAATTTAAAGGAGTCTCTTCTTCGTGGCATCTATGCTTACGGTTTTGAGAAGCCTTCCGCTATTCAGCAGAGAGCTATTATTCCCTGTATTAAAGGGTATTGATGTGATTGCTCAAGCTCAGTCAGGTACTGGCAGACGCCACATTTGCTATTTCCATCTGCAACAGTTGGAGATTGGTTCAGGACCCAAGCTAGTATTGGCCCCACCAGGAACTGGCTCCAGATCCAAAGGTATTCTGGCATTGGAGACGTATATGGGAGCAATTGTCATGCCTGCATTGGTGGAACAAATGTTCGAAATGAAATGCAAAACTGCAGGCCGAAGCACCACATATTGTTGTTGGTACACCTGGAGAGTTTTTGATATGTTAAACAGAAGATATCTTTCTCCAAAATGGATCAAAATGTTTGTTTTGGATGAAGCAGATGAAATGTTGAGCCGTGGTTTAAGGATCAAATCTATGAGATTTTCCAAAAAACTAAAATACAAGTATTCAGGTTGTGTTGCTTTCTGCCACAATGCCAACTGATGTGTTGGAAGTGACCAAAAATTCATGAGAGATCCAATTCGAATTCTGGTGAAAAAGGAGAATTGACCCTTGAAGAATCAAACAGTTTTATATTAATGTTGAGAGAGAGGAATGGAAGTTGGATACACTTTGTGACTTGTACGAGACACTGACCATTACGCAAGCTGTTATTTTCTCAATACAAGGCGCAAGGTGGACTGGCTGACTGAGAAATGCATGCCAGAGACTTCACAGTTTCTGCTCTGCATGGTGACATGGACCAGAAGGAGAGAGATGTTATCATGAGGGAATCCGGTCAGGGTCAAGGTCGTGTTCTGATCACTACTGACTTGTTGGCTCGCGGGATTGATGTGCACAAGTGTCTTTGGTTATAAATTATGATCTACCTACCAATCGTGAAAACTATATTCACAGAATTGCAGAGGGGTCGATTTGGGAGGAAAGGTGTGGCTATAAACTTTGTTACTGAAGAAGACAAGAGGATTCTTCGTGACATTGAGACTTTCTACAATACTACAGTGGAGGAGATGCCCATGAATGTGGCTGACCTTATTTAATTCCTGGGATGAGAGTTTTGGATGCAGTGCTCGCTGTTGCTGAATAGGCGATCACAACGTGGCATTGTGCTTCTTTCTTTGGGAATATTTGAATCTTGTCTCAATGCTCATAACGGATCAGAAATACAGATTTTGATAGCAAAGCGACATTAGTCGTGAGCTCTTGTGAGGAAATCATTGGCTTTATCCTCTTTAGAGTTAGACTGTTGGGGTGGGTATAAAAGATGGGGTCTGTAAAATCTTTCTTTCTTAGAAATTATTTCCTATTCTGTAGAAAATGGTTGTATTAGATGTTCTCTATCATTTATAATATACTTGTGGACTAAAGATATAAGTGCCTGTATAAAAATCAGCCAATTATGTTAAACTAGCATATCTGCCTTTATTGTGTTTGTCATAGCCTGAGTAGAAGGCCTTTATTAATTTTTTTAGAAAGCTTTGAATGCATTTTGTTTGGTATTGTATTTATTCAATAAAGTATTTAATTAGTGCTAAGTGTGAACTGGACCTGTTGCTAAGCCCCAGCAGCATCATCCTAGGTAGGGTTTAATCCCCAGTAATTGCCATATTGCAATGTCTTAATGAAGTTTGAATGTTAAATAATTGTATATCACTT + S##&&""%''%""""#%$%$"%%&(#('''&&%'(''&'(($('$%'#&%)(&')&'%#(%'&&&#$#&$'''(#&(&('$%%&))(&%()%$&&#!$$'(()(('''$(%((#%%'()%(((%(%()(%&$&'&)%&))%%%&$(')((('))#&'')$'('$#$''$$%&$%(')))((%(&&($%')%)))'%(()$')%)()(&$%#&'(($''&'(($('%((#%&))(&#&&(#&&'('##%''%#%%($$%((&#"%%(((''((%$%+*'()(+$((($%(($('),+)*'+)('(&$#&%&$'($&))()('%')$#')'$###"$&$"#"#%'%#%(&$"%%$"#($&)$#$%&)%(%#$&$&#&$##%)%#'&%(&)#$$(%(''""#'%'$%$()%)*))$./01)&*..(+'((&#%*,+)-$$-*)+,,11*/10112.+/0%+-+*(-1,+*$,110,)+$%#&)*+(-*),-&,*0,+.++/.%0',)*+0,12,)*-%&)0%/./(*),'+*(,+,111101*0/+.*.),0,1,1,0&.,*(.1/-1*,0-101.,-./)10()),&+)(%//$."+,),&-*-(-.//0&,-1-+/)11102%0///**,%.00/(&**,0*+-0-,0*)00,,000*/.)00&.,.&-+1,-'00,/+*0.,,0+1+0/./+//$00+0#'*(1010%,11-0,+$-0.).'-'+-0,,)/,01&'&&)0&,-)%.0,1,&'&)/--,/000.+-0+-,,'.&+00(.,+*&../.,0,200*/00-0-0/--*'+*.10-+&)$-.++-*-+',*.10'+.1-/.+*0',,,.-&-*$/--#$,'.00,+.+001-,-/2+-0,&,+-(/)&))*+*#(-+011-+%0/.+1*&,0-*+01&/+)(),++110,($*+-111,+(-+--**.+.+&000-.+/,..&/..+-%..+)$$(+10-().+%.)/%%'/.1-,,+',**+%*-0,011*&.+$.+1&010+),,--./+*)&,(#(((,.)+/*-..)+211&+,'/+(1*()**,'/-.1*.))-1/&//.').*0*0-0-/,00'(%*+-,&,++/11,%-.,210,1*1.(.,./.2-&-+-220%)./+/0/+1.0.'1111-1/',.0,/,'-*./,./'#0-)**(,110)(*&+-1.-/1+--&-102,)(,/&+-,01-,&-'-2,+,.*-...,01)0,0+0-,010-/&+'0&022,-%'*1*+-'0,01-.1120..1)/,0/,00-&,10&.$+'#%*,-0.,,**.*(-)-&,0&/002//&--++111)1/+-*,.2,'+110-,,(*,+,0./%'+)-1110&/.,+&$(,,&'*',-',/')(/()/,*,),+),-*,-+).)*($,((,,.-),-(*)--+$*+%$%,*-,)-,-,'+&-)%)(**'('$&+#$('$)('+,%,-&),+++)--,(,-&$+')'+&$-*%')%,,&$----)+*$(*+,+.%*-,,'*+),(+&,*&('*-)'&+$$)*)(((&%$',)-,+))$)&"$%((+*,*+#)*'#&(#%*+)*(')+-&)'%+($&&$(&)+&()),+&*--))),-,(-+)+,,-)+(*#),*&)(&()#%$($(,-&,,&#%$+&)+*-+,,((--*+#)-,%+,),,%,***'--(,,)',*-,,--,'&(*..-.21/+#'$#)%*'')&0&$*-)%&%$+/-(-,(+)&%*',++--))**(('$((&(%))(())*.-'&))'-,)+(%,+)+))&++,,'))*&&)&)&$((&+$(),*(',((,+,'+,-,-',)$$+&')(+()$$)),. @rCer/264/1756_55_CCS GGACGCGTCCGCCCGCGAGCACAGAGCCTCGCCTTTTGCCGCCTCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGCGACGATGCCCCCCGGCCGTCTCCCTCCATCGTGGGCGCCAGCAACCAGGGCGATGGGGCATGGGTCAGAAGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGCGACATGGAGAAGATCTGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCGTGCTGTGACCGAGGCCCCCTGAACCCCAAGGCCAACCGCGAAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCAGCCATGTACGTGCCATCCAGGCTGTGCTGTCCTGTACGCCTCTGGCGTACAACTGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAATGGCCACGCGGCTTCCAGCTCCTCCTGGAGAAAGCTACGAGCTGCCCGATGGCCAGGTCATCCCATTGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCACCTTCCTTCCTGGCATGGAGTCCTGTGCATCACGAAACTACCTTCAACTCATCATGAAGGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCAGCACGATGAAGATCAAGATCATTGCTCTCCTGAGCGCAAGTACTCTGTGTGGATCGCGGCTCCATCCTGGCTCGCTGTCACTTCCAGCAGATGTGGATCACAAGAGAGGATATGACGAGTCTGGCCTTCATCGTCCACCGCAATGCTTCTAGGCGACTGTGACTTAGTTGCGTACACCCTTTTTGACAAACTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGATTTAAAAGGAACGGTGAGGTGACGCAGTCGGTTGGAGCGAGCATCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTCTTGTTCTCTTTTTTAATAGTCATTCCAATATGAGATGCATTGTTACGGAAGTCCTTGCCCTCTAAAAGCACCCACTTTCTCTAAGGAGAATGGCCAGTCCTCTCCCGAGTCACACGGGAGTGATAGCATGCTTCGTGTAAATTAGTAATGCAAAATTTTTTATTCTTGCCTTAATACTTTTTATTTTGTTTTATTTTGATAATGAGCCTTCACCCCTCTTTTTGTCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGCAGCCAGGGCTTACCTGTACACTGGACTGAGACCAGTTGAATAAAATGCACACCTTACAAATG + (#'$%#%'$$"&&%'$('%((('%&%(('%%%%)'(&')'%%&$)((&$'%$#$'(&))())'((%($($%#(#$$(&(&%''#$&%'%%$#&($((('+(%')*((-,-+),*.'--/'&''&&(&.%-+2.'2/1,,1,,%(/.&*0/+*.+$-$%',-,&&,&---+&0/'..*%'.)'$-)#0.0/.&$$,(,$-%.*)-,+/,&*,&$..&01+*'&(,*$-,&.1'$$21&-110/4-/1400%&(+(-/.-,%,(3++%(*+1'002.0('*-5-+14150531*3%3).&"+-562/.$$$/&314.,+*.0(-*,1-)&().3322532*+(*,20-/+.//*50340-%&'34-2.212$$41+/-(-,2010(-36/164+1-1'3(3+/*/.,(0&/-.+16214//+0.+003-.3//-%+&/5+(,,-'++-+4,4+//10$',6032+.)52411'-++,#04100%(*.,-*&#)-/(&&-$$00.1(,02,/02,-2/0(354/0$%%-2123+/10.,0+,4'/2/&02+0442(3/.*46143222%,/42/('/*++/,')-/---$)-'#-.62//*-0&34*),.0140,$((.0*2-1-,+(*./-,1-231/0.4.-,&/01*1.60)0-114,6-30/-/+%04*243.,+*1,+411,0).)/,/*25,'*0400-*02211#/55303036526660&*,+(/'-0#-5.02/3)./.%+-)/%-4564*#&-+142//.350*/*,,1336,0600-(&#/*05+#+.),/,.1203+-)000/.(&(245/-$//-+/2-&()5*303/-+-1$.,.1(*)10+)/+$(/$)-..26,04.3*500/-,0)1./+.13+,&.10-002*,1031.).25+,1.*54(1011*)$()-,0*/*-0,,-)$',,,*+&,-%*-+./.,+12/./)...*1.&001-+*++-0&.0')$))&&*.0.)0)+(%0)&&/+,1.*/1+**()2.10+,)0.-0)$,)+)($*01-1+,/+/(/.-.+$+(,++$&(''*-(,&'(*((((',,'&&#((%'))),+$(*)+,,(&#'#)+("%%$'#$)+,,(*+,,*'*+&+#)'#%++%$#%(-('#+#+&&,,$$"(++$#,*'&$(%0)+/0)0-+$)()('%10%/*0.**,#+.+'+0,0,-1+%/..%*.%,//+*%*-(0(-,,/&/-+%$,,$#&+-.01'-.0/(01,/)*(+.../-,,,#,('&#/**)''%-..',-,"*,-*+--,.%,%+)+$/0&,+00*2+/*%+,,//,-.1.+&(-%*-'&#&+,&,/0/&1)+..%(+,,'$*+*.%$/,/-%,'#21.02*)%,+-*%&*%0))$+**+/.(+11,0-,,-,!&(/(.--&))*02,+'/.+*$(#'-0**(&#$'))'++0*()-%,+'($&(''#'%*/0('$-+$)'(%./%,&)'(&$--,*,+0)1,&'%$&#,$')'+*+0.**)$.0..'#$()//#,-(1**&/*"*+.,#$(*+&-011),.,,&)%)('*&*./$,'%!$)*#$*+,,*%,//0/',,*/&./%/,-/,(.,.-$+,*.$.,00--)%.1,++///.**))'$((,1+)./%*-&(,(*'.122,20%)'%2*4061000(/40,.1-#-0+.3461400-/.-01 @rCer/269/25_1911_CCS ATGGGGAAAAAAGAAAAAGGAAAAGGGAAAATCAATGCCTATGCTACAGCCCAAAGACTCTGATCTGGATATGAGTGGCAGAGCCTGGGCATCTGCATTTTTAAAAAGCTCTGGCAGCGGTTCTGCGTGCAGTTGGGATTATAAGCCAGTAAGCATCTGAGGATGCCCTCTTCCTAGTTGGACCTTGGGTATTGGGCTTTGGGTGTCCTGACCATTGTTCCCTGCTACAGGTCTGGTCAAGGACGCGGCAGGCCTGCGTACTGGTGCCTGACCACGAAATCCTGCACTGCCACAACTGCCGGAAGGAGTTCAGCATCAAGCTCTCCAAGCACCACTGCCGGGCTGCGGACAGGGCTTCTGTGACGAGTGCTCCCACGACCGCCGGGCTGTCCCTTCTCGTGGCTGGGACCATCCCGTCCGAGTCTGCTTCAACTGCAATAAAAAGCCCGGTGACCTTTAACCCCAGCCCCCTCTCCAAGTCCTTCACAATTCCTTAGGTTCTCAGGGTTAGAAACAGTCTCGCGAGGTAGGCCCTCCTCCCGGTCACCTGCTGTGGTGTGTGTCCTCTCCTCTCGCATCCCAGGGCCACTTTCCCTTAATGGAGGTGAGCCTGGCGGCAGGCCCGAAGGCATGAACCCCTCAGGCAGGGGACTGAGCAACTCAACACAAAGGGAATGAACCTGAATCTGTTGCATTTATTTCAGTTAAAAATAATGAATATATATGTGTATATATCTCTCTCATATATACATATGAAAGGCACTCGGGGCATATCGAGGCTGCTGCTGGCTGCGAAGACGTCACACAGTGGCCCCCGCACAGGGTGAGGTGGCAGTGGCAGCACGTCTTCCTCACGAGCCGAGCCAGGTCCACGGCCACCGCGTGGCTGGCCCCTTCCTCTGCTGCTGTTGGAGCCTTGGAAGCCTCTGCTGTCCTTGGCTCTTCCCTCCATGCCTGTCAGCTGCCTGGGGAGTGAGCCTCCCAGGTCCTTCCTGCCTGAAACGGCCTGAAGGGAATGCTCCCTGGGTCTCCTGGGAGTCGAATCCCAATTCTTGGCTTAAGCCTGTTTTAGTCAGAGACCACCCAACTTAGTGTGCAGGTCACCAGAGTGGGTGGAGGTCAGAGGTCGGGTCTTCAGCCCTGAGAAGTGGAAATGCAGGGGCTGTGCTGTCACTGGTCCCCCAGGGGATGGCAAGGAAGGAACTGAGCCTTCCCCAGCAGGGCTTCCTGCCCCGACGCTTCTTTCTCCACTCGGCTTTTCCCAAGAGGCGGCACCCAGCTCCTCAATCGAAGCACCCGCCTCCCCCACCTCAGCCCCCTCGAGCCCACCGTCTGCTTCTGAGTGTCGCACTAGGATTTTCATTGCTTATTTTAAAGTGTCTTAATCCTTTGTTCCCCGACACATAACCCTCTAGCTCTCGGAGGGGCGATCATGAGAAACCTTCCAGGGAAACAGAGCACAGGATGGACTGTTAGTTGTTTTTAAAAGTCTATATATAATTTCAACAGATCATAAAGAAAAAATTTATCTCTTTGGTCCTTGCAAGAGAAGTCAAAGGAACTTTTGTTTCTCCTCAAGAGCCTGGACATCTCTGTCTGTCGTGACTGGAAAGAGCCCGTTGTGCTGAAATCTGTCATCATGGTGGGTTTGATCTTCAGTGGCCAAACATGAAGAATTAAAGTGTAATTCTTGACTGAACTGGTGGATGGGTTGAGCTTTAGGGAAGCGTATGGCAGTCATTCCTGGCGCGCGTATCGGTGTGACATGAGCCCTGGAGTGTGTCGTCCCTCTCAGCCCTGCTCCTTCTGCCTCCTGGGGCCCAGTGACTGGGCCCTGCTCTAGAACTGTGTACCATCCAATTCGCCATCATAAAGGAATCTTCCTG + EA/G?G3JEIHEFFB)CAEA9@GF;HIGEGCEFD@C)7;GDIAHIHHGFG@C:FI@8FF;EGF6IIIIAIIF2:CCFFACF<49GFEEDHAE?DF.IIJI@H??BI9HFF;BD8F@E?I@DII>8J5CJHHE8JJIII?HHHAJB:/4=I@<<@GCIIHGH%@>HEGIHFHH=IB(=;D9?GGD-?:IC*A3B>E8AFFFGB=KEJJGJIJAJ;KGKEJHCFJJJKDFEF5AHIIJK=KCIJI>HJIJGH0EFJF$GAIDKJJJ9KHDHKDIJF8IFGJIEFH@&:7AFF=<0AKIC?KID+E>9DIJF?AHKKHKJKK+>AKKIHHEKK3GE?=KKHGGF@KFHHJHDI:=BB9KKJ>IF(HBAJ4DIKKIJJAE@5D:8?AD5CJJFID8?JJD#CCKFEJKJ0EE6DIE:HFAA?:DIJGE;BFF@GFIJA=BJJIJGHKEKKDKAJKJJ'JJI>BECFJJJ7HJKKFFIKIAFEKJJKKKG:BG9FICGKFKKJKJBAKKK5KJKJJCHJGG9JIKGFKH;G9KKJK?K5HIJJGIKJ5JJI@K&IJBEKJKKI3KJIFJBG:HDKJHCJEGKKJKHCGIDGJJJA=BD>F?FF?GBH4F;GBJFA;CIHIFGHKKFI;JHJJC:E:EAIHB?IHHKDC:E;IIBDJH.EJKKDF:FFHIJKGG@AKC,DGDFF&C@=GKIJIACEIJH>KDKGHIAFCJDK;%E@EI>>HIKJJG0C@2IHHGHJCH3<@>>9FH6DGFHKJBHF7GEEBBF4?KJJ=J?F7F?GHGAGIF7BB&E<J>FIGIKIHADI?C<=A6GDCD8FJBH4HHHFHDIJE?I3E?A@@EID;AC?EI@FKHFJCGCHAHKGGF+FKJ7HAC@87JKI:JHCBCF?CCGC8JHHFIJH8'GEHJFGEJBKJFJBJIEKJ3KJJIJKHJHAKFD0JI6JJGFJJCJKJKIKKIKHKIKHKKJKHGJKIGKGHIHJFKJIKKKIJKJKKE4EEKKJJ@KKJJAKCKK=JHK@@G6GCKIEKJAJKKDJKJHFFI?HJHGKKCKHEGJKKKIIK?KJEKKKJEKKKKIHJDECHKKKGKKFJHKCFKJF9KIJJGGJGKIK:KKKKKGJA=KKJKIKJJKGHJKK?KJFJIKJJKEJIKJJ9KKKKH;GKJKKJD@KK9KKKKJKICKKHHIIKKGDIJEKJJGJHKHKC?KKKGKGHI?EKEKJKJAJIJHHDDKIIH@KGKJKGJKI3KIIEJJEHJKEKIKKKKKIKIJJ@II>KBGAAKDIJFKIKJIKJDJKBKKFCJGEACKI>EFJCKIHK;HBK8BIHJH>KFKFJJHDIKJHF=GG;?DFKJBKIGHJGD>EJF6KJJJKJIKJKKE?DH+IEFE@H0IIJKIJJKF-IBI?@DEDIK>KIBKJH1KKJGEDKEIBJJ>KKKKEHKGKKKE8HDE/FJK8KJJFKKJKIKJBKCJJ>KEKJIEKKKKKKKKJKKKJKKKIHIJ#KKKEGKFHJGAFKJKJKKKKKIKKJIKKKKKKKKKJKEJKKKK=KKKKKKIKKKJK9KAKKKGKKKKKKKKKKKKKKGIKKFJKHJKKKKGKKBKKIKKJKKKKKKKKKKJKKKGEKKKJJJKKKKKKKKKKKKKKDKKKIKKJGFJFEB:C/=;;8+740'4=/)A=$9<;B?6>B<=>2:/-(;64);2>$<-95:3CCA%/1=A2BAB?:;?*@5:>9B?;BAD=A2$1856:=(B@.::55%?:8B@0D>DD>)858(,69<<=F>:(9<#4:68='=8/49/%855<7CB=6@=:5#:;9@B;,:,;=8;?A4C=57C?.B>C>BB9>96@;;737@.43<55=7B;4C-1,3A7:9B79C2878<8@3A>@430AB6+*@><(;/;=?58=3A>2CCCC@>>;29<2555:9:=@;->:7+%290&198-039=>B;A2'>?>/87<=@=6'@=66=82<2;8204<79=<>''&>;=:4./2CCA0'<=>=>=@;2@?C'=*=A>+?A;(=4CC46.6?4/@&=885+3<>47-65;AB;CA3@>(=>:4,833'8;:-<@B=CB?A?<<1:806/6/1868<:<4/+4>;2@@0<+?1?<$;7-03?=?:<9;?@=66:6B:=8/<<>11367:$04;>6388@6<75@'80>23=??=?>B=/*)?<=0;<=7?/34==2<>,@==@=C;50B6.4A=/>7=<%.4>.;1>;6::.A/6?>892@@71=89?B-:.)4%>5>6->6C:;4B@:=<07;@;<27A&7>@>;5+;9A?9>6<76*$,%:AAA68)&71B;C?96BB@7?=6??78-58@7=:7?=&1+;6;96,B;62>%.0>9474:476.3534@B?44>;7>44*4=;4)<4A7<4($2>-@=C:<<9<>95=>@>:23$*/..9;C<973@,8*;,%6&871;.@.5AA;9;68,=)<=@B46)8658:.+533.'0+/2;,67,::?9?(@33:72<;93+/+.-44@@,88-C?<0E.A24=693?;7%6?BA09?3?'>DC@G6>:DAA(==%'#6,(44DC<=DC=@6079-067>@.==6:@B@31>GCAEC?:7>/?AB88A=?@6199$:;3A<;:=*80678B;<84D8%/2:?90=???9'66F;>:<:CB89#0-/B>&>=>=@9>85+0.'@84B5BE(ACB@A672C6:C@AA,=>>?6@A)9E@B'>=@??>:25#'-(55>88$4.19,>34,5:=?>AA819/5@964>=:?@@9:0BC?@4=40;2?60+1>>AB<>C=70;,4:$8-3@1<4,-48415>:57B7A;8(40@@C>:7=.?9;:4<=-;47)7930:/:5=729&3@&;88C68>@8?=&6A>@8CA<:%788@18@95=6<*:=-;;>4>67'8%;'A<38;.1%220<*@A<6=:/@96=5C;1=80A09+<<382<:=;1<:9:==;=862687&*%&7;<)=7;<>?9A.?@A(8:C@(//-@88>=7<8>182A=1:9-845&790$$((8A?=,-6::1<64<+4(,+*<69&/858:@?8?&@<<%5=0?A6<(9>@>.;-.9B:B5<@B0@45?@4259*4--<.%;,*%@?>'9;0=:4&?A7$06(28.),+8<(7*7?53206.+==+52=<-<:A;>-4899A7=2',20&8<=./&<7 @rCer/273/25_2145_CCS ATGGGAGGCTCAGTGCTGCGCTTCGCATCTGAGGCGTCTGCTGCGACAGCTCAGTCAGTCGCGGTCTGTGTGCCGGGGGCTCGTGAGGAGGCAGCTCTTCTAGTAGTGCTCGGCGTCAGACATGGCGGAGGCGATGGATTTGGCAAAGACCCAACGGGCCTACCCATTCCTCGACTCTGTTCGTGAGGGAGGACGGCAGCTCCATGTCCTTCTACGTGCGGCCCAGCCCGGCCAAGCGCCGGCTGTCGACGCTCATCCTGCACGGCGGCGGCACCGTGTGCCGGGTGCAGGAGCCCGGGGCGGTGCTGCTGGCCCAGCCCGGGAGGCGCTGGCCGAGGCCTCGGGTGATTTCATCTCCACGCAGTACATCCTGGACTGCGTGGAGCGCAACGAGAGGCTGGAGCTGGAGGCCTATCGGCTGGGCTCCGCCTCGGCGGCGGACACCGGCTCGAAGCAAAGCCCGGCGCCTGGCCGAGGGCGCTGCAGAGCCGGAGCCGCAGCGGCTCGCGGGGCGGATCGCCTTCACGGATGCGGACGACGTAGCCATCCTGACCTACGTGAAGGAAAATGCCCGCTCGCCCAGTTCCGTCACCGGTAACGCCTTGTGGAAAGCGATGGAGAAGAGCTCGCTCACGCAGCACTCGTGGCAGTCCCTGAAGACCGCTACCTCAAGCACCTGCGGGCCAGGAGCATAAGTACCTGCTGGGGGACGCGCCGGTTAGCCCCTCCTCCAGAAGCTCAAGCGGAAGGCAGAGGAGGACCCGGAGGCCGCGGATAGCGGGGAACCACAGAATAAGAGAACTCCAGATTTGCCTGAAGAAGAGTATGTGAAGGAAGAAATCCAGGAGAATGAAGAAGCAGTCAAAAAGATGCTTGTGGAAGCCACCCGGGAGTTTGAGGAGGTTGTGGTGGATGAGAGCCCTCCTGATTTGAAATACATATAACTATGTGTGATGATGATCCACCCACACCTGAGGAAGACTCAGAAACACAGCCTGATGAGGAGGAGGAAGAAGAAGAAGAAGAAAAAGTTTCTCAACCAGAGGTGGGAGCTGCCATTAAGATCATTCGGCAGTTAATGGAGAAGTTTAACTTGGATCTGTCAACAGTTACACAGGCCTTCCTAAAAAATAGTGGTGAGCTGGAGGCTACTTCCGCCTTCTTAGCATCTGGTCAGAGAGCTGATGGATACCCCATTTGGTCCCGACAAGATGACATAGATTTGCAAAAAGATGATGAGGATACCAGGGAGGCATTGGTCAAAAAATTTGGTGCTCAGAATGTAGCTCGGAGGATTGAATTTCGAAAGAAATAATTGGCAAGATAATGAGAAAAAAAAGTCATGGTAGATGAGGTGGTTAAAAAAAATTGTGACCAATGAACTTTGGAGAGTTCTTGCATTGGAACTGGCACTTACTTTTTGACCATTGCTGCTGTTGCTCTGTGAGTCCTAGATTTTGTAGCCAAGCAGAGTTGTAGAGGGGATAAAAAGAAAGAAATTGGATGTATTTACAATCTCCTTGAACAAGTATCAATGTGTTTATGAAAGGAAGATCTAAACCAGACAGCAGTTGGTCTACATAGTAGTAATCCTTTGTTGGAATGGAACCCTTGCTATATTAGTGACAAAGTGAAAGGAAATTTAGGAGGCATAGGCCATTTCAGGCAGCATAAGTAATCTCCTGTCCTTTGGCAGAAGCTCCTTTAGATTGGGATAGATTCCAAATAAAGAATCTAGAAATATGGGAAGATTTAATTATGAGGCCTTGAACACAGATATCCCAAACCCTTGTCATTTCCCCAGTGAGCTCTGATTTCTAGACTGCTTTGAAAATGCTGTATCATTTTGCTAACTTAGTGTTTGGGGACCCTGCTCTTTGGCTGTTCTTTTTTTGGAGCCCTTCTCAGTCAAGTCTGCAGGATGTCTTTGTTTACCTACCCTCAGTTTTCCTTAAAACACGCACACAACCCTAGAGAGTCTTAAGAATAATGTTACTTGGTTAATGTGTTATTTATTGAGTATAGTTTGTGCTAAGCATTGTGTTCGATTTAAAAATTAGTGGATTGACTCCACTTTGTTGTGTTGTTTTCATTGTTGAAAATAAATATAACTTTGTATT + ??.AC@@AAFEB-*8C>><7<=@FFC@B=>@EAGF9EDFFE>9ED9BFA@CFBE@CBBEACF*C8:9CCEA49A%CCCCC>?B?CD'9A+;=CEEACC?FEC>DA5AAEBF3=>:?FC9DG@B.>?>E@;??ADB=@@3@8*>DCGG>>&@A5DB&A>6A;?)B=?<@4BAEBDFFB?E@FD@<@=.EDC>D5B%5=3?@<FE@@E@AEFAE6E;>A@@C3G*B>D2EFEGFB@=A;6B?CDED@EF@EFAGDC8AAA?73-D2DA@@F?@@A:,CF/CEEAG?@GFE+?(%CE?BEF=@;7C.FEF0A,A9?FGCBFB>AB;AECB99?2?F@F;?DAA=@CDEC9E7C>>AC1C9>+FACFAAEEB9EEAFAA&B<3B)C>?=GEBD=9BCE=BB;BDE@<;DDB?EFBAD9?:6.@DEECECEFA2F>CD6A@GEBD>DD>C8;FCBC@4EBF;E?<@*>AF=AAD=G6@9AGGAB=FBE>CE@2ADC@0B+CBEEA5=@GBAAB>9C4CC=3D<>GAEA>=3CB5;G*B576>BB@CC;;A=FBC@FCA:4@=EEE/?DBB61%?5B=:C?78;?8CBCBFEFA=2@@C5??-A@C@D,DFGCEAE>D8?8?CGED&@;AB;B=%=ABB4<2;=CFAD?DBE5?*=57@EB?CCAH0E:?IA8BD?IF>??IBAG;DA3G9A@D:A>6;5A=7DFF-=C@=?C;<$;:=?EIDDEABE>2F>BDC;4FCA@9,56=2A+DC=CFGEFC@H=92:->84AHEAG8HFDAB@B?EEHFHFI?EC@>>4@,F;>JF8BC=EA6G0+HCDED9FHDCEBJIJDCD4F8(G@=ECDD.C>=FE0H@>E:9HJIGF?=AAGFGDFBDEG/GGII2EHDI3?BA<7@C9?:BFCD=3B?>2AB<>A:@F>(G@@=978C@@E@DG@D=FFDJC?@8BH6FGAD=FFG1IJJIJJIFEEGD/FE?EI=C@9?5>AHF?GBD<@B@G@A;2==D7=?DC1<<;A48@7=<9*;;@?;(8632.&==94:?6:4A?:A1>'==<=-<54>;EEEF@6?3-CB;A*(=*:A;>832=?=<7=47?48;4FB5CA>&C@*B@69C-G:EB8BGFF;AA5==7;=B@=7C;8A=ADB@'>=BC)EF@EBFD?D=@?DCBFDBD3B91?ADD5E6?*8>CBDCB;CDFFD=5AA@?>@>EAECC6CDBG>CBE@>>D=C:GE;GCECAGC96:-BD/BA1FA8=9:@8586(459=A85AE;AAC=81;@=9CA>ADF>@EB@:DDCEC??D61#@7,7@?AA;:AA>?@>3F3A?4EBF:3:>7AD>B=;1>D5+:<;::B=GA<+:1=?;:BEF>F=EBCDA>7CBGC>FDD2;874CF@ADD=$?;8?FF5FE?7>6>1EDC>B>2=E:7;;B2B><9?78+:8EA=:47:4B@C@DBEBFF2EAA6@:9=?@;@C?F;CFFFF7A<;<04::%97AD:=CA#<91EF0D>C@?3CACAG?@3?=EB0A>:D@CD@BC@2@B1C;?<(942:?:AB;GGFA@6> @rCer/275/1673_57_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTT + KKKKFKK9JAKKJKKKHKJKKKKJKKKEKKKK=KKKKKKKKKKKKKEFKKKKIKKKKKKKHKIJKK4GKKKKKFKBKKKJKKKKKKKKKJJKJJIKKKKKJKKKJJKKKKKKKJKKKKFKKKKKKKKKKKKKKIKKEKKKKKKKJKJKKKKHKBJKKKKKKKKKKJKKKKKKKKKGKKDKJKKKKIKKBKJKKKKKIKEEKKKHKKK*KKKJKKKKJIJFJKKJKIKGJKKKJKKKKK?K=JKKIKBKKKCKDKKEKKKK?KKKKKKKKKFHKKKKKEKBCDFJKKKKKJKKKBKKKKKIAJKKKKJKKKKKGKKKKKKKGKKKKKK?KCHKK+KKKKKJKKKKK>=EKIJKKKKEJKKF>EJKIKKJKKKKKKKKKKKKKEKKKKIKKKKKKJKKJIKKK>KKKKKKKKKDKKKKKKKKK9KKKK*KKKKKKIKKKJKKKKJKKI9HJBKKKKKKHKKKHKKKKAKKKJKKKKKKKKKKKKKKKKKKIKKKKKKKKIKKKKJKKKKKKBKKKKKKKKKKKKKKKKAKKKJHKKKKKKKKKIKKKKKKKKKKHGIKKKKKKJKKGJKHKKJKKKKKKKJKJKKKK3KKKKKIKKKKIKKKKKDKJKIKKKIKKKKAKJKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKJKKKKKGKKKKIKKAKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKKJKKKKKKJKKKKHKHKKKKKKKKKKKKKKKJKKKKKKKGKKKKKKJKKJKKGKKKK1KKK:KKKKKKJKKKKIKKKKCKKKKKKJKKKKKKKKKKKKKKKKKKIKKKKJIKKKK9KKKJKKKKKKKKEGGKKKKIJKHKKKKKKKKKKKHKKKKKIKKKIKKKKKKKKKKIKKKKKKKKKKGK;B>62::;(@?C8=<=:@=A@BB5=;6=3B;<6=3>=@B54==>B7>A8?;A0?=;>B692567(95C=@?;;9<8:79>807B9?<9=A9?=A>@@;58367;=;4=93;==?==6<>>>56>?;>70=8=88=6;;:9;>:549;::&;8><;96?;<*.<==5?=:2;:==;==>;><<:878>>=3==6<=,;3:48>=:6468;68-8>=?=:<9:<07#2,6<:2;>;78>=;=;>799805;.;;;<>9::=5;/969=8989.76/6:;=6<:;3<=;;74;=8:98845>6511382=;;:>>?<93<99?=675:;767);=7>;=5>:;3/:5/78;0740889;=0067=<8.7:724626583567870/86%&53-;:489<66<;:-<::.;<6;759=51::>6/2/447.;=<:7:<55::4=959;4>9:;/65>:?=><93:4+1:9178;:7;>>=<625>67<7:>=:0779732837,66$594;8=80;<;6:58/6>9795788<26=6=507.585:?==?=8:8=2>/?9?B?:=?<=7=@438@=;?=>.;?>=9;@=:>5:BAB;==;:<:?A>??@@;283.6=;8:562;=;;;8B+@96C====;?@=A;C>?::88275:9<&;<;?C>8696;9'48<@<:<;>/=@:-BA@@;=C<@>A;@:;=<+<>>1?>99=9>A??;A;4<=7B>?;655>;?9A?>A?>;C:B@@AAA;8?A<:<>9>@<@?B;=A?8C::@>;?524=;@';>62;<*@89:>6;5+6<97<6A>8>=>,?BA?C=;@<6A>:<>6:;9:5<BA79<=@<4B?@=@<9C6>AAC:7<@6?:.;6BA@?C8?3>>A=A9?A>?=B?@A;9A8;6?>BAA>?,8<<=:9<;<>6;>$=?3@==>@AA@=@=<@676-@=?AAB?6&4<<:=@C@>>>77==>=&=@A@>B49;>;443=:A4=;2?CAC=B@?:A?06+193646>==;-?@6>8@>A@===;62:9:;8B>AA9;3>;4?B>?-9>;;<9B>A@=B<::;8==AC:>>?;?A47:7;8:3??@9=A?C>;>:96498>648BB:51;9&;=C?><=>701?#<=77;B@<=:?;9?;:=)=?-:7>997>8@3*A=:=:=>AB?A@7>=-:9=A?4=@=949+831>>@49>,?>8=??-<79?-<9873=<30<:>>?:6?=?B>C@A9@?<@<@CC<@:=4@;67;0;8=:<<&>:6@A:+<845<<;6,:23:91551:=:1<9<>@>-0@;65=@@=<>?=B1<@<:/72A;97<:=:+:<8==9>7@B54663<9:A>2>;@??=@63AA::@1A:=>>.;C@;=;B@9A?@:@=?>A:CAB=??-/?BBBBA*A?@:< @rCer/279/813_52_CCS CATGTACATTACATGCTGCTGCGGCTGTTTGTACGCCGTGTGCGGTTGATGATGTTTCCAACAAACCATGGTTCAATGGCAGAATGCGAACTATGAACGCTCTGTGACAACAGCGCTAGCCAGTCCGCTGAGTTTGGTTGGTACTTTGTGGCCCCACTTGGCATTCGTAATGTGTGTTTTGACGCCTATGCAGTATCAACTTACCGAGCCTTTGCGGCCACTTTGTGACTGGGTGAGACACTTGGCCAGAGTATCATGAGAGCTGCTTGCGTGCTGAGTCGTGTATGAGATGCGATACAAAGCTCATCTCTGAGCAGAGTGTAGTATTCATAATGGAATGGTTAGAGGTGGTAGAGCTGTAGATCGTGTATGAATCGCGTTGCTTGTACTGGATGTGTGTGCGGTGTAGGAGCATACTGCCTCCGTGCAGTAAATGGTTAGAAGGCGAGTTTTCAGGAGGCCTAAACCGGCCTGTCCCTTTTGAGAAGGATTTCTGAGTGCCTTCGTGGGCATTCTGGTTATTGAAGCGATGAGTGATTGTGAGGAAAGAGAGGAAAAATAATAATGGTCATCTGCATTCCTTTGGCAACTGTACAGTGCAGCAGTCATGTCCCAGGATTTCAGTTCAGCTTAGTGAAGAATTAACTTTATGGTAGATTGTTTATCACATTTTGTGATTTGTCGTTTTGTCCATGAAAATAATTTAATACCAATATAATATTTTCCATGATGTCTCTAAAAGTAAATATGATGATATAATC + .,&+,+"&,'-)(&++)-*,+.&%-#+%,)&,-..%,-),&.**('(),,+%*%&###,#(+)',%%#(***&,-++*(---$+(.*&((%#$##!$"&&$(+..,---+,$+--,,.*+..-+---(%/(.-&(.$,'%("'(*"$-*)%&+'*--&$.(**/*-//+(#-$#+*'$#+(+&.(,&,%('''$.-$-./-*...''%')#&%&&#**',-.%$(),,,'.+%'$-%'(')&"$%'..'+(,&-..,..%##.,+,,'*)+,(-'(",("&#%%+---'(#/*/+--.*)".-+#,-#'&+,(..-,,(,*)($#$""%&""#$#"#%"#$&$#-%+&$#$(&'*"&))*)+$%*((&##'!*+&++*'##+*'$%#,(&$&",.--*+),.,+)..,/(*,+*.(*,*)*.),-/,./(+-"%-,),&.-+-,(.-*(#((*/.+%)$'%-%.().)+)+.'#,)*).&#$(.,.",).-$-/)//%.+*(,')*+&)$*-+%.'($(%*'%%.,/.).&-/*++-/+--*/&***,--*//','#+.--%-/.'/,,$//.*.-.,$..-((-(-*$*.-+*,-(+,-#)*(,++%,,)"+).,'.%($--,)).$./,(.-+.$-,(--&/)-.**.+-+".-.,#()$#%%-,&#*&#(++*.,)(,--/.',*.-+#.#.,'().-*%"$++'+.,,/-/*.-*+,&)'(,,),&+,*(*(&*%'&%+,(&)&#"'#$&"&"$'"+ @rCer/281/25_2236_CCS ATGGGGAAGCGCAACCGTCGGTGGGTCGGGGATCGGTCGCCTGAGAGGTATTACCTCTTCTGGGCTCAAGATGGACAACAAGAAGCGCCTGGCCTACGCCATCATCCAGTTCCTGCACGATCAGCTCCGGCACGGGGGCCTCTCGTCCGACGCGCAGGAGAGCTTGGAAGTCGCCATCCAGTGCCTGGAGACTGCATTTGGAGTGACGGTGGAAGACAGCGATCTCGCTCTCCCTCAGACTCTGCCAGAGATATTTGAAGCGGCTGCCACGGGCAAGGAGGTGCCGCAGGACCTGAGGAGCCCTGCGCGAACCCCACCTTCTGAGGAGGACTCAGCAGAGGCAGAGCGCCTTAAAACCGAAGGAAACGAGCAGATGAAAGTGGAAAACTTCGAAGCTGCCGTGCATTTCTACGGAAAAGCCATCGAGCTCAACCCAGCCAACGCCGTCTATTTCTGCAACAGAGCTGCTGCCTACAGCAAACTCGGCAACTATGCAGGCGCGGTGCAGGACTGTGAGCGGGCCATCTGCATCGACCCCGCCTACAGCAAGGCCTACGGCAGGATGGGCCTGGCGCTCTCCAGCCTGAACAAGCACGTGGAGGCCGTGGCCTACTACAAGAAGGCCCTGGAGCTGGACCCTGACAACGAGACGTACAAGTCCAACCTCAAGATAGCGGAGCTGAAGCTGCGGGAGGCCCCCAGCCCCACGGGAGGCGTGGGCAGCTTCGACATCGCCGGCCTGCTGAACAACCCCGGCTTCATGAGCATGGCTTCAAACCTAATGAACAACCCCCAGATTCAGCAGCTCATGTCCGGCATGATTTCGGGTGGCAACAACCCCTTGGGCACTCCCGGCACCAGCCCCTCGCAGAACGACCTGGCCAGCCTCATCCAGGCGGGTCAGCAGTTTGCGCAGCAGATGCAGCAGCAGAACCCAGAATTGATAGAGCAGCTCAGGAGCCAGATCCGGAGTCGGACGCCCAGCGCCAGCAACGATGACCAGCAGGAGTGACGCCGCCCGCTCCCGGTGTGATCGCGTCCTTCCCTGGCTGACTGGAAGCCTCTGGTTGTCTGCCGTTTCCTCCTGTTGGACTGCCCGAGAGAGGGGAAGAGAGGGACCTCGGACCTGCATGTCAAGATGGATTTTCCCCTTTTATCTCTGTCCTCCTCCACTCCCTTTTTGTAACTCCCTGACAGCCCCCGAACCCTTCTTGAAATGAGAGCCAGCAAGCTGAGCACAGACCAGCAGTGACCTACCTTCCAGCCCCAGAAAGCTCAGTCACCTGAGTGTTTTCTAGAATCCTGGGGGACTCCTGGGCCGCTCTCGGAGAAGCGACCGGTTTCACGTTCAGCCGTGTGGCTTCCAAAGCCTTTTACAGCCCCGCCCCCCATCCCGTGGTGTGTCTGCAGGAACTCTCCCGTCCGTGAGAAGCCGCTTTCCCAGTCGACCTCCCGGCCACCCTGGCCCCGTGCCTGCTCGGAGGAGCTCACTGCCAGCCGCGGCCTGCGCGCCATGGGTCATGTGTGTTTGCATGAGGAACTCTTTAGTGGCAGACACCTCAGAGACGGCTGTGGTCACCCCCGCCTCCGCAGCCCAGGAGCCGTCCTGGGTGCATAGGACCAGTTTCTGTGACTCTTCTCCAGTTGGGCATGTTGACAGACATGCGTTTCCCCTCCTCCCACCCTCATTTTCTGGTCCTTGCGACAGAACCAGGGGCGACATCATGACCTTCTGTCCCGGCCGCCTTAGCCCTGGGCACAGGGAAGGCAGCTGGGCCGTTTCTGTCTGTCCTGTCCTGCTGTCCTTCTGTCCTGGGTGTTTCACGGACCCAGGGCCCCCCCAGGAAGCTTATCCCCCTATTCTGGGTGGAGGCCACGGGGTACCTCAGGTGCCACCCACCTTGGCCCTAAAACAGCCACCAGGAAAGCAGCCAGATAGCCGGACAGCAGGGGGCCTGTCTCGGTTCCTGAGGCCTGGGGTGGCAGGCGAGCCCATGCGCCGTGGTCCCGGCTGCAGGGTTGTCAGTCGGAGTGTCCTGGGGCTCCCTGGCTCTTGGCCATCTGTGAGGTAGGCGCAGTACCGTGTGTCGTAGGTAACAGTAGGAACGGGGGCCGCCGCGGCCCTGCAGCCCCTCACGGCGGTGAGGCGTGTGCCGAGCCCACCCGGGGTGCAGGGCGTGACGTGTGAGGAATAAATAGGCATTGTGACCT + IJ+KKGCKKJKEAHEJEFIJKH3JKHJ5JJF=HIKKJ;EHFJJCID=F>HHJCCGKHIJ@HIJIKBKD:H+JJI@7CFF;FJI%IKGFJKKKIIHJDIB@4J>KHGJKJJJKJE5HCHGI/IGF?DB:KKIGFKJJHKKKBGI(B>HKJ@;JBGDH@CI?I?EAKIKJJK@KJGKJIKKKJFBGKCJIEIK-KKHEJGJK@KKJEIJKKDKGJGIKIKKFIKJIKIJJFIIHKKBKHHKJKKEHJIE,CIKIHKKJJJJDHKHKGEJGIBKIBHHII(JKFKCEKJKKKKKFGJJGIKJGIJ>KHGJJJJ9AB8IIKJJ5J?KHBKKKJ5=H@KKK?KKK@HAKHG:KJEJJGKJKAKJKHKHKKKGKDKKJ/C9KIKJIGJJKKEGGHKJJKHF@KIHJKK4IBH?K:JKJKFIBKKKKI-KKKDIHHK;KGIJHJFKKI6JKKJJ:KCKEKHJGJK3HJCK+FHK5JDKJIKD?BJJ>KJFK.KKKKJJ77GIJJKKJAD?KKJKKKJKJ8KKJJG9JKJJ:D6@FJKJHJIBJJK7KHIK9KHHJJDJKDHJKIKJKKJKIIAKJJI:EKJKGHJKGKJIG-KJEJJJHJIIG@IJJGJJJ?KGFKJGJGJHEGJKIKGIKKKH?=HK8KKBEIFKKJKHIAJHK5KJI7KDJKKKJCG8IJ>JD@?JK=KHGEJKKKJ5KK@GIIKKK=KKKKIIKKKKIJFIGJ>JKKFKJBHEIIJFJKIHHKKBKIKKJKHJJ;C<=EJKK-KKD8JIK6EKKGFJKKKKIEJD@IJJKFKKKKKJAKJKKIJDKIKJHGFHGIKKH?KHKJKFC%KHKKJ'KKIJKKJJJIKJKKKKJBJKHJ4IKGIKKJJKKKHGK7KKJJBKKBD>IIADJJ>FIIEFIDECGJHJAFA?CHHJ$ABDH=KECGJKACKFEKHIE3IFG7JEKIFIKK0H5)JJJJHHC?GAKKKJKF@$DDFE<@?IE5+II?EKIDJ*JHJ6KJKJDAKBJHFKJADKH?J@DIKHKFKHJKJ;KJEJD?JKDGF9EHAIIIJJJBJKKJHIJ>K=KJKIJIA1IKHKHJJHHAKHGKHHFKBGBIKAKH$KIJHHGKKBHHJKKDJJIEFFKKKKJCKF'IEDK>?JKI9KF7IKKKJKIKIKDCCCAIKCJKKKJJJJKICKI>J6KKK>JIADEHGKKBKKJIK;ECEHGH>KHJIGKKKJHH9KGJKJ?KIJIJ3HF)GFCJJKKDKJJFH:IKJJIDC.GFHJKJJCJIEKKKDFHJDGJJD.KKIH>KJG=JF(KGA@FJCKHKKGHIJKIKKGKK8JKE6IKKKKKKKKEGKEKHKKKJKKKHKKJ1HKIJKKIKJKKHKKKKKKGJKKKKJKJKGKKKKKKKKJFD42@KKKJKKKKKKKKCKKKKCKJKKKJIJ?KKIK@HKKHKJCKKJHJJJKHKDAIJ;DKJKKJ;KI5KJ;K8GKKKKJIKKJ6KGKKKKKCIKEBKKKKK>JIHKGJAEKJKIJJJFJK@KBKEK8K3IKKKCKKKKCKBKKK@KKFKBKGJIJIJJKJJKHGFKBKGKKKK,KKJKIKAKBK>JHKA@KKKIJIBIB?IC:JEKKIJKKK?KJKKGKKKJHJJJJKFKI9KKIIKKEKFIIJJKKKDKKJJ7CFF&JKK=JIKJEAIHJ4?J=JHEKFGKKJIFKIDHEJHKKGIK1;JIIGJ5KJADDGKDGGB=?FJHJ=JHCJGIFJHIHFEHKHKJKIFACIEHCJKJIIJ0JKIJAD:IFGEG;DKIJFECGJIEG)FHKIJKBGJHJH8JJEJEBIHG<@JJKKGK>E>F@EFJ7JIII5FJFKGJI*EHHHFE2IJKKFFHEIHJ7JFKKEGHJE@GKBIKIIJKEJKBIFG/KAKJI:FKKJJJDDHD8JIECGKHDIKJJ7AJHC?E?EFJEGHIKK?JGIAH=F>HKIIK?GICIJHFHEAAKKKKJ:KJGGKKKAKKK>BE:HIIIKKEJHGFGH>JDBAIHKIEIHKFFKBIIJEJJJJE;IDGB4;FG;D9GE3EHHJ@HKKGCHJ8FF1HIKDEJE=HI7JGIIKKKBIKGII4IKJJII@8J9HJACHII7HE;GJKI=JIGK=DIJFDEHH*JKKHADKFKJJ>JIG?JJJJEAFAB@8>HIKJFKIIKH:FJJKFDICKKBE9IJI=HH:DGJJ2EJIFIK==/F1-FG0JKE+I.ECA@5FHJGKJA;KKIHJAIFKH@JC*B@&GAKGKJ.G31>HCAH=KIJJEJJB6&KBBKKKG>GJKFKGJIJJI+I=H9@K?G0D:BE1H:.J5'AB8-FJ,FIE4IH>EJH1K@;.KJDK4KIK?HJDG,JEDKJ:?A:D6JHHKKIJ6GEJJG*JKJD21&J4IIEK:JJIJ?FJ1D/>GGK@KCHKF=AIKKKJKJD>KK@FKKKHJJE2IFJKB7KFGJ@KKK@K6KFCDKEJEKJIFH@DJHKK:JK+KIB2JKK>KHHIKKKKJJG4EGI5;KA'F?JH:>,KEFKKAKKKI7@GIK:KKJJKJG$@K+JK8HFK,KKK8KGKGIGK>BCKJ-ECIJJ9EH;=JKKI7?IJGKIKKIHKGIAK3KJ2?EFKIKKEKBJK7K.KC@KJKAC-IKKJKCD?D7J>6J2;KFK.3KKI-IKIHIIKJFKJK=KCC?@KIFKKHG?K5JKJJCGIHKKIFHKKKKKG(KKKHHHEJKK7K&JJ>2J.;<<%K0>KJKKKKJDIKKGK&G$'KI>@=<5AEKHI:KAGGJIIKI6JBK;1HKDKAG'KKHKKIHDEFK:K:KKK3KGJKCKK@KKKKK.J&$KJIKBKICJKJCKI>CK?K7,KJHEKIAKCIJKEFEKJKDKKJFKICFKK>FKK6K>K+K=K:K8KH??KK;KDGI;=?GKCIJI+GGJIJKKEFJ%KKKKJI@'J/4F>,KK6KHIJHIJJFKGJKJIKKHK%KKKEKKK=KKJJCKKKKHE>KJ6B.KBKK>KKJ.KKI@KKKKJ*KKHKAK;EJDKKIKIJKKK@KJJ;J@KKAKDFII>KKKIKI50K.KKJKKJ+KKGKKKK>KK3KKIGKK$KJKKGKKKKK:EIH>KKKJGKIFKHKKKKKKKGKIKIKGKKKKGKJK?KKKIJKKKJFKKKKJKJKKKGKKKH/KJKKJKKKKIKKKKKJGJ1JJGJ9BKJKHKIKKKKKBAKIHKKK%KKKKKKKJKKJJKKJKJKKKKIJKKKKIKJCH4KCKJKIAKKKKKKJKJKKKKKKKKKII>KJKKFKJKKKKK/KKKKKKKKJKKJKCKKJKIKKIKKKKKKKKKKKKJKKKKKKKKKKJKJKKJKKKKKJKKKKKKKKKKKKKIKHKKKKKKKJKKKJKKKJHI7KKFKKKKKKKF6KKKJKKIKKIJKJKKKKJKK7KKKKIKKHKKKKKJK&KKKKJKKKKKGKKKKKKKKKKGKKKKKKKKKKKJKKKKKKKKDKKJ?KKKKKKKKCKI@KJKKKKKKJK7KKKKKKIKKKKKKKKJEKKKIKKKKKKKKKKKBGKIKKKKKKKKKHKKKKKHKKKKKKJKJ5FKKKKBKJKKKJKKHKKKIHKKK(KKK1KKKKKKFKKKK&KKJJKHKJKJKKKKKKEKKKKKFKKKDKKKJKFKKKIKKKKIKKKKKKKKKKK7KKIKKKBKKKKKKKKKKKKK>KKKKKKKKKAKKHKBKKAKDJKKKKKKIKKKKKKKDK @rCer/290/382_58_CCS TCTCATACCAGGAGCTCGGCCCCTTTTTGTAGCTGTGACTGTCACCCTCTCAGGCTTTGTCTCATCCTTCATTCTGAGGAGATGGCAGTGTTCTTCTCTGGGCCTGATCCACTTTACACCAGCCAGGAAGCCCCATCTGTGCCTGCCCTGAGGTGGTCCAGCAGTCTCCCCCTTTGGTCCCCTTCCAGTCTCTTCCCCTTTCTATCCCAATCACAACAGAAATGCTAACATCCCTGCCTGGTAGCCAGACTAGCCCACTAAAGCTCCCTGTAAATGGGGGCTCCATTAGTTCTGCTGCAGAGACTAATAAAGATTTGGTTGGCT + (($%&*'%*(/)%+.,+1+/.*%*.21)/),0,,1*01,0-1,00,--,/1))))%($(10/0+/0,/+-(1--+,-,$'/100-'*//,2-.,$)&'%,0&.,0(,/,*-,.'#(&*-'0/-%./(/(1/.1..0'*))'))-0.2,)/11...#-+)10-4/0450/5.*(*)4/-+/+$0(5,26..985)002'16))04/0-$0(/+'&)(002&,(0520/(0**-.)'#+-26.*+10../-)/4562.1.).0$&10-0(7360.)02287.109426,57577.:68435091,750*267.8511(70844)4. @rCer/292/2288_60_CCS AATGGGGACCCGGAAATGTTATTGAAGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAAGCATTTCCCGTGGTTTCCAGTATGCAGCCGATTGATACTGTGTCTCTACCCAGTACAGGGTGGCAGGCTCTGTCTGCACTTCCCAGTGGCCAGATGAGCCAGTCCCGAGTATGTGGATAGAACAGTTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACGCCACACATAAGCTTTCTACTACCAAAGGTTCCCACAGCCTGTTGAGGAGAAGGTTGGTGCTTTCACAAGATAATAGAAGCCATGGATTCACAGGACCTTTGAAATACAGTAAATGGAAGATAAGATTGCGGCCCTGCGCATGTATACTAGCCTGTGTGGAGAAAATGACTTCGGGGAATTCTTCTAGGTGTCAGATGCCTGATACATTCATTCATGGTTTCTTATAACCCTACTCCACGTCTGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGAAGAGTACATGTGTCGTATGCATAGTTCATTTTATTGTGGGAGGATGTTCAGCAGCCGCGGCGAGTCATGGGGTTAATCCTATATCCTGAAAAAGACATGATCCTCATGACAAATCATTTCTATGCAGCGATCTTGGGATATGATGAGGGGATCCTTTCAGATGATCATGGGCTGGCCGCTGCCCTCTGGAGAACCTTCTTCAACGGGAAATGTGAAGACCCTCGACATCTTGAATTGCTGTAGAGTATGTGAGGAAACAGATGCAGTACCTGGATTCCATGAACGGGGAGGATCTGCTTCTGACAGGGGAGGTGAGCTGGCGCCCTCTAGTGGAGAAGAATCCTCAGAGCATCCTGAAGCCCCATTCTCCCACTTACAACGACGGGGACTTGATGGGCTGGGCCCTCTGCACGGCTGGCCAGCTGGCTTCGAGGAAACCTCCAGGAGAGACGTGCCTGTTGGTCCAGGACCCCGCAGAAAGTGGCCTGAACTGACCTCTGAACAGCAATCTGTCAATACCTGCCCCATTTGTGTTGGTTCTCTTAGTGTGCCCAGGAGTATGATCTGCTGGATCAGGGATGGGAGCACCCCTAGCTCTCCCACGTGTCCTCTCCCTCGGAAGCCCGAGTGAGAGTCCCCCAGCAACACTCCCCAACCCTCCAAGCACTACCTGTGACTGACAGCTTTTCCAAAGGCAAGGAAGGGATGGGCATAGGTTCAAAAGGGAAACCCCCCAGGGGTTGCTGTGGCCTAGAGGCGGACTGTAATGCTGCGGAATCTGGATGGCAACCATGTGTTGTCCCTCGGCTTCCAGCCATGGGGTTGAGTTGGCCATTAAAAGAAACAGACTTCTCTCTACCATGGCCCTTCTTTATTCCAGGACTTAGAAACTCGCCTGAGTTGGTGGCTGCGGTAGTGAGGGCACCACCCAGCTCAGTTAGTGACGGAGAAAGGGAAGGGCTGGATGGTCTCTGCTGCTGCTTCTTGCCTCTAGTTCATGGAGATGTGTCTCTGTTCAGGCCAAGGCACAGCCAGCCAGGCCCCTCGTCTGGGACCCAGGAGGCCTCTGATGACCAAGGGCTTTCACATCCTACGTCATTTGGATGAGGCCTTGAGACAAAGTCACCTTTGTCACAGTGAACTGATGAGGAACATGCTGTCTCCTCTCTTTGGCTCCCCTTTCATGAGATATTAGGGAGAAGAGAACATTCCTCCTGCTTAGTTGTAGCAGACCCAGACCGTGCCCAGCTTTGGGCCCCTTCCCAACTTCTGAAGCACGTGCTGCAGAGCCACCTTGGTCTGAGCAACTGGGACCAGCCCCTCCTCCCATGCAGGTCATCTCTTGGGGATTTTCTTTAAAGTGAAGAAAGGGAGTGGGGAACCATATTGCCCTTCCTCCCCCATCAAACTTCCTTCATTTAACTTGCTATAAAATGAGTCATATAAAGAAACTCTATATGGGTGAGGTATATCCCACTTCTGTGAAAACATTACAAAATCAAACCGCCTCTCTCAGTTTATTTAAGATGCTTTTGTTGCGAGCGGAGCTCTAGAGTGAAGCTCCTGTGTGTGTGAGATAATAACACCTTGTAACTCATTACAGCTGGGCACTATTTACATAAACCAGAGCTGAGCCAGGCAGGAATTTGCTGATTTAATTTATTTTTAATGGAGTGAGTATACCATGCACCAAAATAAACTTTACTGTGTGTAC + ,),---((++'-+.)+'#+,--)+,',-*--,,)---+'(,.,)+)---(.,-))(&(%,,,-**)%#&+)-.*),#&(-)--(()+($(----(-,--.*(--*#+---&%$('(-*)$**'')%%$)(&,,-&*(,)(,*)#++,-',-'+(,,'%#()')&,,-((*,-*)),,&%$'*,),$$'+))*$'*,),-((',*$&-,),-++,,-.,+,.----,)---((-((('+),.)&,--)*(+,&(+&,+&+('$-*&&),,''(**&--.,*,-(-)-,.,&,--,('(),$(&#%$,,+,&,.-*'-)&+')***-+&+(--)+++&,)(,-,)-()()())"#'')&,(,-&'#$$--)----*'&%%%&%"$&,--*+,)*(*--#)*-((&(%#&$.+(')&#&'$$&#(()*'#'&,&())+))**)'&((''()&,*'$*)()''(&'*,),-)*(,*,(##'''*))$((,*$,)()*,((+(''('%$('-)()'+$#"#'('(,%#*''&%&$&%"%#'&('+,+'&)(&'#$&$'$)*')-,,)'*%&,+("'((+#'%%)%((--,)'(,,,)%)('&(+(&))$'('&#*'--+(,%,)+-))(((%(%#$%$%%((%%%#())'('$$'$(&#&((&()'%$$"#)()('%%$$&#$#&%''$"&#%%(%$((((&%(%&)&%"'%'&%%&)(()()(&'(%$$%%%(%('''#$&&%'$'()())&$$#'$$%$&$%'(()((')((&%&$#'(%((%'$%$'%&((%)%%(()())))())(%()'(%$$()%()'&')%()((%('%()((())'%'&$%($$$#'%()(((%(&%%$%#$"%%())'(&&'$()'%'''$&#)((('%')))%))('$)()'%$$"$'()())%')()'#')&(()()'$#$$&%())))()(($#'%()%(($%&$%%%%%#%#$%($($((%#$%'&'%%('%(((%($%%'%(()(#$(()%(((('%&%($$"$%())'&#&$&"##$$$#'''$%%%'##$&""'%%%%%&'))))'%''%()(%'%()((&()%$##'((%%()$'($#$&(($%''((%'))(())))')%&"'))')'&$)(&'($()('))(('%&(('%'%##""##&'(($&"#%"&($$#$%&''#('%(&&%'%(%%#%%)()#'#&)$$""'#(((%(($((('%(%%$)()('''&"()(('%)))))$#())#"!('#(()('#$$#$##%)('%')))'%(%$())'($())(((()(&&%)((%(((($('((#'))(()&((%$(&(())))))(&()()(('%)'&%%%%$&$&$'&$'$%''%'(%'%($%$(&%%%()))((%&$#(%%%'$%&((#'%('(%'%(()())()((&())))))&((('%())'$(&()'%('$')(($%(((%#'(%'%))((&%&%%&$"%()('%''(%(%$#$$&&#($$%&%$$'($$$&$"(%()()#$((%%%$')%%'$%%&)&&%&$()))())))()%$$##%%('%())'%&'#()&()()('%'%()(#$#%$))(()%($#%%()&%()'%()))(&($!&()%&"%$(('%'))(&*$&-*(('+)'(,-,)+,&(&'#%#('(-',*--,*-*&(-,-((&+($&$$')-+'&((+-()---+'-,-.-,,&)(**'*',))&)%&+$%$,-),,+&)++(,+$'$"#&&*-#(*(,-),)*'($-.*,-,&%&&+')+).--,+,&,,+(,--(')+,'(--),,&,+,'+*'**+)'#$)#++&--**()(#(((&&%##'(,,,&$'%"&)'-&)('#()*+',)(&,,%((*)*-..*-.)(-++--(-(*()*',$+-.+-)-''%&#&#,&(+)&(,),()%,)--).,-.-),,(*++&#'(+)(('()-*),-,-*)),-++'')-)+-++)(,,$(-.*,-.+),*(((,*$(,+'*)---(-*,+(-),,&#+,(+-,(+-)-.,-*,(),,')*,&*+&)(**(--),-,--+)+)---&&"")-$)*&($&&&%&$%#(---.,**+'-++&+%+-+*&'+(------(---,))-),*-,..-.-,*),*--+&+&*----.,+(,-&')-,$$)$,*(,+,++,,$*#*-*)('%#(+&((-'+-)'+-,-)&%'*,$&,*)+&*,,),,*,- @rCer/293/1854_51_CCS AGCGGGAGTGTTTGTGCCCCGGAGCTTTGATGAGCTTGGAGAGATCATCCAGTCTGTGTACGAAGATCTTGTGGCCAATGGAGTCATTGTACCTGCCCAGGAGGTGCGCCCCCACCGTGCCATGGACTACTCTGGGCCAGGGAGCTTGGTTTTGATCCGCAAACCTGCCTCATTCATGACCAGATCTGTGATGAGCGAGGACAGGAGCTCATCTACGCGGGCATGCCCATCACGGAGGTCTTCAAGGAAGAGATGGGCATTGGCGGGGTCCTCGCCTCCTCTGGTTCCAGAAAAGGTTGCCTAAGTACTCTTGCCAGTTCATTGAGATGTTTCTGATGGTAACAGCTGATCACGGGCCAGCCGTCTCAGGAGCCCACAACACCATCATTTGTGCGCGAGCTGGGAAAGACCTGGTCTCCAGCCTCACCTCGGGGCTGCTCACCATCGGGGATCGGTTTGGGGTGCCTTGGATGCAGCAGCCAGATGTTCAGTAAAGCCTTTGACAGTGGCATTATCCCCATGGAGTTGTGAACAAGATGAAGAAGGGAAGGGAAACTGATCATGGCATTGGTCACCGAGTGAAGTCGATAAACAACCCAGACATGCGAGTGCAGATCCTCAAAGATTACGTCAGGCAGCACTTTCTGCACTCCTCTGCTCGATTATGCACTGAAGTAGAGAAGATTACCACCTCAAAGAAGCAAATCTTATCCTGAACGTAAGATGGTCCATCGGAGTCGCATTCGTGGACATGCTTAGAAACTGTGGTCCTTTACTCGGGAGGAAGCTGATGAATACATTGACATTGGAGCCCTCAATGGCATCTTTGTGCTGGGAGGAGTATGGGCTTCATTGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGCGTATCGTCATCCATGGGACGATATTTCATATGTTCTTCCCGGAACACATGAGCATGTAACAAAGCCAGGAACCCTACTGCAGTAAACCGAACAAGAACTCCCCCCGCAAGGAAAAAGTGTACAGACAGCTGCAGTGGAGCCTGCTTATTTAGCAGGGCCTGGAATGTAAATAGCCACTGGGGTATAGGCACCGAAGACCAACATCCACAAGCTAACACCCCTTCAGCCCACACAAAGAAGCTCATATTTTTTTTTATAGCATAGAAATAAAAACCAAGCCATACTGTGACTTTACTCTGCACCTGCTATATTTATTTCATGGAAGCATCTAAGTACTGTCAGGATGGGTTCTTCCTCATTGTAGGGCGTTAGGATGTTGCTTTCTTTTCCATTAGTTAAACATTTTTTCTCCCTGAGGAAGGGAATGAAACATTTAAGGCCTCAAGATACTATACATTTAAAGCACCCCAATGTCTTTTTTTTACTTCCCTTTCTTCTTCCTTATATAACATGAAGAACATTGTATTAATCTGATTTTTGAAGATCTTTTTGTATGTTATGTGTTAAGGACTTGTTTGGTATCCCACTGAAATGTTCTGTGTTGCAGACCAGAGTCTGCTTATGTCAGGGGGATGGGACCATTGCATCCTTAGCCATTGTCACAAAATATGTGGAGTAGTAACTTATATGTAAAGCTGTAATACATTAAATGGAAATGCAAAAGCTGTGAAATGTCTTGTGTCTTAGTTCTCTGTATTTATGCAGCTGACTTGTCTGTCGTAACTGAAGTGTGGATCCAGGACTCCTAACTACTTTTCATCTGAATCCACAAGATTCTGGGCAGCTGCCACCTCAGTCTCTTCTCTGTATTATCATAGTCTGGTTTAAATAAACTATATAGTTATCAATGAAG 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@rCer/294/25_1612_CCS ATGGGCCCTGAGCTGGTGTGCAGCATGCTGCGCCTCTGCTCTGGCACGCGGCTGCCTGCGCTGACCGTTCATGTGACTCAGCCGAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGTTATTTGGATCGTAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCCGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCGTTCGTGTGCTTGAAAATTGGAGCCTGCCCGTCAGCCCATAAGCCCTTGCTGGGAACTGAGAAGTGTGTATGGGGCCCAAGCTACTGGTGCCAGAACACAGAGACGGCAGCCCAGTGCAATGCTGTCGAGCATTGCAAACGCCACATGTGGAACTAGGAGGAGGAATATTCCAGCTTGGAGAAACCGCAGCATTAGTTTTTTTCTACTTGTGTGTCTGGGAGAATGAACGCACAGATCTATTTGACTTGTTATAAAAATAGGGCTCCCTCACCTCCCCCATTTCTGTGTCCTTTGTTGTAGCATTGCTGTCTGCAAGGGAGCCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGGCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTTAGCCCGCCCTCGCATGGCACCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGCTTCTTGACTGGAGGCCATCAACCCTCTTGGCTGGGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGGCTTCTGAGGTGGCCTCCTGCCCTGGTCAGGGACCCTCTCCCTTTCCTGGGCCTCTCAGCTGTACAAAGCAGCAAAACAAAGGCAGTTTTATATGAAAGATTAGAAGCCCGGAATAATCAGGCTTTTTAAATGATTTAATTCCCGCTGTAATAGCACAGGGATTTTGGAAGCAGCTGCTGGTGGCTTGGGACCCCACTGGGGCCACGGTTTCTCTGTCCCTGGTTCAACTGTGATTTGGCTTTCCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGGTTCTGTGGGTTTGGGTGGGAAGGGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCAAAGGCCCCGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACGTGTCCCTGGCTGCTGAGGTGCTGCTGCAGCCTGCACCCCTCCCCCGTCTCATAGAGGCTCCTTTTGACCTTTCTTTTCAAATAAATGTGGATGGCGAGTTCCTAGGCCTGTGGCTCCTGTTAGAGGGCGGCATGCTGAGGGGTCTGCTGGGTGTGGGTTGGACGCTGGGGTGTGGGTTGGATGCTGTCTGCAGCCCACTTGGGCACCCATGCTTCTGTCTACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGATACGCAGTTGCTATTAAATGGACTTTGTGAGTTTTGTTTTGCACTAAAGTTTCTGTGATTTAACAATAAAATTCTGTTAGC + JC-JH=JKKKJFJKEJIKFHJKJKKEJJJKJCJIJKIHKJKKEKJAIJBIGKKK*IGJKKJKJJCKKHKJFE?JEHKKKKJ->E3KKKKJKKKDAC;KDFJJHKKKK8HKJKKJKKKKIDKHI?KJE4EKKKDKKBJJKHKKK/IIF9I9JFKKHKHKKGKJDJ:JE-C@JH6ECE;HJKKHJJJBGJIGHJKGKKKKCKDFJFJH@F?KJKIIIG4KJJK4KFB6=FKJKKHKIKKI9KKEKJH>KHJBK?J'JKKJJJKKKHJKKKKKGKKK%=14??IHK8KJJKJKGKIIKFJ4JKGKF%HF@JHC1KKGH=;DKKHKBKKKAA?KJ/KKKKI3BAHGE=9EDEEJKKJHKCJE;GCKJGJKEFKIICK/KKHH/FJKKGK4KKKKEKEIHAFAIJHJJFA?EK@JHCK8KKAJG?FGIJGFKIKHHHI@IJEFJJJBFC<5EKCKKEKIK>JKJKJBJJEHIIJJ3>JDH5FG??D8<6I=8E=DHKKJJ/DHE5KKKIKAKKJJKJ@GHEBK@HKJJK4KGG1KF?G?86IIIHGCIEKEEJHJE?HGCGI-:BIK>H9KJFK,HEKK?IJDKIJ?BDE.H9HFFHEAFIDGGKJJHI?F3JKBHKK>KKIDKJKDKFJ:CJKI8KKAHJKKKK9KJJCDJIJKHHAEB579IBIAG?AEHE1JHD3BF5DHACAKHIJKGF<7IJJIIHKHKJ???KKJIAHKDIEH/@KKKH@HBJJFFKDKJKJ4GHHFEI8CGJEKFKKKKHKKKJJBIKIKKKKKFKKCKKKKKKKK@BJKKK1JJFKHIJKKKJBCKKKIKKKK8KIFKKKKJKKKIKJIKKKJKKJKIJIKKKKFKKJKJKIJKK:KJHKKIIAKKAJJKFKKK>KKKKJKKHKKKKKKKKKKKKJKKKKKKKKKKKKKJKKK8KKKKCKKKKJKKAKKJKKKIKIAKKK@KJKHKKKKJKKEKKKKK)HIK&KKKIKKKKKKGKKKKKKKHKAIKKKIGKJKKHKKKKKJKKKKIKK6KJKKKKKKKJKKJKKKKKKHKKJEKKKDIJKKFKKKKKCKK@FKKKBJBKKKKEJKKK9JKJAJKKK(HKKKKK:KKIGDKKJKKJK?KKJKKKKKKKKKKKKKKKKJKK>KKKBKIKKJKKKKKKKHKKKKKJKK>KKJKCHKHJJJKK?KJKFGKJKKJKKKKKKDIKKEKJKKJKKKKJKKKKKK=KKKIKKIKBH@IJKJKHKJKKHKKKKHKKKKKKKGJKKKKIJKKKKKK=KJKIKJKKIKKJ7KJKKCKJKIJKHKKKKKJIIJEKKKJGIKGJKKKKKKKIKKKEIKKKBKKKKGJKKJKKIKKKKKKKKKKKKFJKJHKIKKK?GJKKIKKKCKKKKKHKGKKIKKKJKKKCKKHKKKDKKKKKFKIJJ=KIFKDKIKKKJKKKKKKKJKKKKKKKKKJKKJKKKKKJKKKKKJGKJKKK9KJKIKKHKKKGKKKK;IKKKK/HKKKKKBKIKKKKKKKKKKKKI?KKKKKKKKBKHJKKIJKKKKJKKKKKKKJKGKKKKIKJKKKKKHKIKIKKKK@KKIKHKKKKJKKKK>KJKKKCKJKIKKAKKJKKFKJEKKKKKKKKKKKK*BKHKEKIKKKKJKKKKKKKKKKKKBGKKKKKIKKKKKKKIKKBKJKIKKKKKKKKJKKKFJJKKKKKKKGKKKKKKKKJKIKKJDIKKKJK5DKKKJKKKKKKKKJKKFKBJJKKK>KKKKKKKKKKKKKKKKKKJKBKKIKKKKIKKKHKKEKIJJKK1FKBKJKKHKKKKEKKKKHHKJ2JKKDKKKKKKJKJK3KFIIKCKJKGJKKIKKKKBKIJJHJHJHH@JKEKKKKKIKKHIKKKKKFKKKKKJKKJI@KJKKKJHKJGGBKJKKKKJKIKKKJGKJEKKJKKKKJKJKKKKJKKKKKKJKKKKIKKK/KKKKFKIKJKKKK/KKKJIKHKKKKKKKKKKK?KIIKKKJKKA:KKIKJ7KKKKJIKKKKKJKKKKJKFKKKKKKKDKJKKKKKKKJKJIKKKKKKKKKHKKKKKKKKKKKKKDKKDK;GIKK:KK6KJJEJIIKK@KKIKJKKKKKIKKIKKGKKFKIKKFIKEHFAK(KKHKKKKK3HKBJKFKJKKGKKHKKK=KEEKJKKKKKKCKJJKKJKJKKKKIKCKBKKKKJKKKKJKKKKKKKJKJKFKKKKKKGKKKKJKKKKIKGKJKKKIJJ@KKKBFKKKKKDKCJKKKKKIBKKKK+IGKK=GK?KKEKKKJKKKKKJ5JKKKJKK9KKKHKKKKEGIJKIKKKKKIKKKKHKKDKEEEKKKKJKKKFKKKHKI42<968;=;<9?4<1826==8:6)3=>978;886>9=49==>18872/86+837860;<64:7.897;=63/1604;=>;3-'221969;>5>>0=09:9=5;:6:<<;<>*:>83:89289;:=79>7=:=;=?>?>5<3=9999<<<7=8<;85968=;:1=<9=><8:>79/>=96:7?65=64586=3:<;=<=:;;>73;=>:==>2:<4=:;9==;?=<66=::9:+:7=;>>>>=5:=9>>64:=8592775==95::818=9425=,9;-)>>:?6;;;>;?>9;?8725492;:;=>);9983<;28?07:>;8=054:9=<5><0=>9;=5<<3=6?;==.:9.:87>==70;<;6286/03058=9?:??6<@?>;581/876:;;>:;A>A<'@@>:31;?8)88:;6?>=23;?7?7>=5=?;A8>><<<>;@@?>3?CB>?>221>9AA:7@?;><<3>;98A?@<;:>CA:=;A:>>@B>?>A=4>B:=><=>@A-C?919:3?>70;725B??@A;6?@5?5&2<::CAB>=B::>@=3@B3?8:==<;5<89>C<<>;<;:=>=7AB?4>=ACA3A@A?713>???A@=9;>==>?=5?8==;?>>+A@><<5>A<=)74999<@@:9:495@A>=@5?>@BA?=AACCA?>>??9A>@2<@:A54<@6?@,9::6@C;:@6=>86;B;??8/7@<9?@=ABA9A>;B>>?>-@;;:;@<<@:>>?@:@;?A@;-?>>=;9>8>;0=9:905.6;9:?;=8A=<>0A;2?=>A>@B?A=A-4A>@;?4A?@>97?:3;+==*8/586364-;<9==<;:@@399<(@0>?82=;>32<9(=5@:=>?:64>A>A=:B=:7<@6?=A>?>A>=9@@@@:<(@A;B@7:C>A8>2?2?<@=BCC><;=A9<418?7?/:3=A9CB:B9?B>B;C9AB>9A9??:4?5CA@BB@7<=7>B6@@A@C@@B>;6=C=AA<846?>=-@AAABAB@@@@=@7BB@;4;>4A?>>>>AA8>:3@:@BB:?<>??7B@B>>@8B=??@4?>AA?AB:A8ACB>:;:AB9B;;@<=@95:@@@7@@=AA.>;C6;?=;C>@=:7@A5>9A?A9B>ACA71>>B?B>:2@AA<4@=>>8@@CB=?7BB=8??87C=5:;??<=,<8<>1=A?;:B=@CB8@A<>>?B@@77=AC@;?=C?@=88<5<@B@B;A>ACA=7=:@@?;@B8BB;>>=A/=CABCBB<>A>B>B><=@>?137=:;8?@>AA>C:CB?@@@A76ABCA8>;>=0?AB>CACAC<=??=;?/@:;<B?@@==C=?==;A@=6@<:ACA<90=?=:@6@2>.<<@=139:>@AA<-@@A<@A<<6A9;4<3<:>7<;ACAA>FCB;E=C@>?E9EA:CEB6?4=B@@F?FFEA@FA@/>CBGGFBG=2@BC@CG1A9?BBA@>?@>DEEEF8C@=@;BCE?CBD;@E:6D:>A>9;A?E:CBB8?FDE;A;EFDC?+?B?:>=?DF?FD/DFFACEG@?A:>?9B3>< @rCer/307/0_2040_CCS GAGTGCCGAGCTGAAGTTCAAAGGATCCTACACCAGCGTGCCATGGACGTCAAGCTGGATCCTGCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTCCAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATATCAAATAGAAGCCTTGCTGATGAGAGCCTGTGAGCCCATAATTCAGAACTTTTGCCATGATGTGGCAGATAACCAGATAGACTCTGGGACCTAATGGAGTGTCTGATACAGAACAAACACCAGAAGGACATGAATGAGAAGTGTGCCATCGGAGTCACCCACTTCCAGCTGGTGCAGATGAAGGATTTCGGTTTTCTTACAAGTTAAAATGGCCTGCAAGGAGGACGTGTTGAAGCTTTGCCAAACATAAAAAAGAAGGTGGACGTGGTGATCTGCCTGAGCACGACCGTGCGCAACGACACTCTGCAGGAAGCCAAGGAGCACAGGGTGTCCCTGAAGTGCCGCAGGCAGCTCCGTGTGGAGGAGCTGGAGATGACGGAGGACATCCGCCTGGAGCCAGACCTATATGAAGCCTGCAAGAGTGACATCAAAAACTACTGTTCCACTGTGCAATATGGCAATGCTCAGATTATTGATGTCTGAAAGAAAACAAGAAGCAGCTAAGCACCCGCTGCCACCAGAAAGTATTTAAGCTGCAGGAGACAGAGATGATGGACCCAGAGCTAGACTACACCCTCATGAGGGTCTGCAAGCAGATGATAAAGAGGTTCTGTCCAGAAGCAGATTCTAAAACCATGTTACAGTGCCCGAAGCAAAATAAAACAGTGAACTGATGGATCCCAAGTGCAAACAGATGATAACGAAGCGCCAGATCACCCAGAACACAGATACCGCTTAAACCCCATGCTAAGAAAGCCTGTAAAGCTGACATTCCTAAATTCTGTCACGGTATCCTGACTAAGGCCAAGGATGATTCAGAATTAGAAGGACAAGTCATCTCTTGCCTCAAGCTGAGATATGCTGACCAGCGCCTGTCTTCAGACTGTGAAGACCAGATCCGAATCATTATCCAGGAGTCGGCCCTGGACTACCGCCTGGATCCTCAGCTCCAGCTGCACTGCTCAGACGAGATCTCCAGTCTATGTGCTGAAGAAGCAGCAGCCCAAGAGCAAACAGGTCAGGTGGAAGAGTGCCTCAAAGTCAACCTGCTCAAGATCAAAACAGAATTGTGTAAAAAGGAAGTTTTAAACATGCTGAAGGAAAGCAAAGCAGACATCTTTGTTGACCCGGTACTTCATACTGCTTGCGCCCTGGACATTAAACACCACTGTGCAGCCATCACCCCTGGCCGCGGGCGTCAAATGTCCTGTCTCATGGAGCGCTGGAGGATAAGCGGGTGAGGTTACAACCCGAGTGCAAAAAGCGCCTCAATGACCGGATTGAAATGTGGAGTTATGCAGCAAAGGTGGCCCCAGCAGATGGCTTCTCTGATCTTGCCATGCAAGTAATGACATCTCCGTCTAAGAACTACATTCTCTCTGTGATCAGTGGGAGCATCTGTATATTGTTCCTGATTGGTCTGATGTGTGGACGGATCACCAAGCGAGTGACACGAGAGCTCAAGGACAGGTAGAGCCACCTTGACCACCAAAGGAACTACCTATCCAGTGCCCAGTTTGTACAGCCCTCTTGTATAGCATCCCCACTCACCTCACTCTTCTCAGAGGTGACACCAACCCCGTGTTAGAGCATCAGCAGGTGTCCACTGCGTTGTCCCGTCCAGCCTCCACTCATGTCCATGGTGTCCTCCTCCTCCTCACCGTTCGTGCAGCAGCAGCAGCTGGCCGCTGGGGTTACTGCCTTTGTTGGCAACTTGGGTTACCTGCCTGTAGACAAGTCTCTCTCATACCAACAGAACTTCCGGTACTTCCAGAACCAACTCACCTGACCTGCAACTCAAAGGCTTTTTTTAAGAAAACC + @4?;=2::4579C;CC;A@:?@4:?BDGAEC;:DCB4D.A;BA>;?DDBFB5EC@7/>6;<;;6590-8?<>=>?CB>;BA?BF1A?3>:=6D>ADE866?.?;BE>FDF@B@D@::7BC8>@@A9?=F4A=2B;AE?6<,>=CG<>E=A235(BA5D1C,CEA)8@8'@BDDDG;A@A?FE:FCEE=B4BE7BFE?C872A90)DB4?>D*>79@?;F>E>0ED>>5;:<4B.:<459B?DC@2)*?+7=7@?G88D3C>BBB@6GCDE?C2C=EB?BD:A>C>:@:6C9EA*B>?7C-DE><6@883<@+>0:CFBAA38DFD:>>;=2EBA9A8,;>6?,@>>FA;82>>AAA;0??D@CG>EC<>D8=>?B=B?EEDEC49?FDE?E9D==G2A8B7873=779ABF2=57E>=?;=A@8B>:>>AEF>;CBG>@A;CB-<>6>/./82&8=<>A?DD>A9?3CDC5EGGFBE@A=?FFADFE<=@B=A-A;F;:7:2@=@*@BAA9DE5ABDAD??+ECE?=DB=8*043?(B:B+@?<8C:FB@DB;CB7A8@FDAC7E?ADF;BB8:?9.77AB?AEB=7GED71@4F=7EF>>DC3BBC8EF<;///AF:4@4@@:EDA@AF:GBC@@1D??;@@C;8;=CBED?BEEBD5E@>D>@BGD82>:<><@5$)7EB=2>3E?(5596B=?+:<=+A?6?ADCA6A@?@45:@>?9A?E6=5B898:-@@C=)>?B<@/>>B@80@@;B<868;=EBA>C>>69?CC1B::13>=?,>??DD<@B5D;BBD,DDC>BBBCAFAEG9BFDA<@?5?@A=2:C7?@B?@FBE;D:B@2=D+DAC?2GFEA=:9:29:1A@@(>84/:=@E??>8;;4>A9;;C:E@DF8E=>C>7A>?CEFC?49:?@BA>0E<4**B/?BD+A?FA?;CAF?@85A?D@A:A@FDD>G;5D<@1D?C8FA?FB2C4B>C6A.DDC>@?CD'CD@AEGF4D=B5D@;2=F5=A+?B4?79B7/A98:F8AA;CC?/AD&=83D*>@?8>A<<;AB%9=>?C9D9?%488?A?=?25?B=?@AAB/ABCE:=@;BA8>B?>?D>BE=BA>ACCBC@?@AC?@49/BA*<3??C@:E:F::7B;@A8BAFAG*A;=7B8DE>EIHBJIEEHJI:FE@B>BEJ=HH?J=?E=FGCGHKFDFHB@=4,=4BED36EF>6@=BBF:D/DCBBD;E:>@ECGFCD?CAGB/?=F>E6G@9AF=EA?DJAEB7E?GE5F=?F/EE9@@)CIIIFD5?G1EFH9F @rCer/308/25_1569_CCS ATGGGAGAGCTAAGCGGCGCTGAGCTAGTCTGAGCAGAGCCGGGCGAGTGCGGCGGCGGGCCTACAGGACGCGCAGGTGGCGGTGTGGACATGTCGCACGGTCACAGCCACGGCGGGGCGGCTGCCGCTGCGCCGCCGAACGGAGAGCCGCCGAGCAGCGCGGCCTGGCCTATGGCTGTACCTGCGCATCGACCTGGAGCGGCTGCAGTGCCTTAACGAGAGCCGCGAGGGCAGCGGCCGCGGCGTCTTCAAGCCGTGGGAGAGCGGACGACCGCTCCAAGTTTGTTGAAAGTGATGCAGATGAAGAGCTTCTGTTTAATATTCCATTTACGGCAATGTCAAGCTCAAAGCATCATTATAATGGAGAGGACGATGACTCACACCCTCTGAGATGAGACTGTACAAGAATATTCACAGATGTCCTTTGATGATACAGAAAGGGAGCCAGATCAGACCTTTAGTCTGAATCGGGATCTTACAGGAGAATTAGAGTATGCTACAAAAATTTCTCGTTTTTCAAATGTCTATCATCTCTCAATTCATATTTCAAAAAACTTCGGAGCAGATACGACAAAGGTCTTTTATATTGGCCTGAGAGGAGAGTGGACTGAGCTTCGCCGACACGAGGTGACCATCTGCAATTACGAAGCATCTGCCAACCCAGCAGACCATAGGGTCCATCAGGTTACCCACAGACACACTTTATTTCCTAAGGGCTGGCCAAGGCTCCCATAGAGGTGCTGTGTCAGTGAAGATGTACGACTACTGTTGGAAGGACAAAGGGATGAGGCTCCACAGAGAGTTGGCTGCCACAGCCTCTGCCAAGCTTTGTCTTTGGGCTTGCTGCAGAAACCTGGACTACGGAAGATACGATACCACTGGGAGGTTGTGTAGTGCCAGGGACCATCGTTGTTCTCTAGGCGCTGTGGAAATTGGGTCTTGGGCTGGTAGCATCTGGCAGTCATGGATAACGTTTGCTTTTCCAGTCAATGTGCCATGTGATTCCAAGTGTCATGTTGCTTTGTGCAGGATTGTTGTGTGACTTGTTTTTTGTTTTGTTTTGTTTTTTTTAAAGAAACTTTGTGGGTTATAGAAAACTTTCTGACGCCTCAGGATTGTGTTAATAGTAGCCATCAGGAGGGTCTCCAATTAAAACACTTGTTCCTGCTTGCTCCTTTCCCCTCTCATTGTTCAGCATTCTTGTCAAGTTGCCCAGCTTGGAGTTGTCTGTCACGCACATGTGTCCTGTGTTATAGCTAGAAGATCAGGAGTCTCCTGCTGATGCGTGATAGCTTAAGCTTGGGAGAAGGTCTTTTCCACTGCCTAGCTAAGCAGTCTGGGAGAGCATGGGATCATTTCTGTGTGTGTGGGTAATCTGGTCGTAAGATTGAGACTTAGTTAAGATTTCCCTTGGAACTTCCTTAATGTTTATTAGCTTCTAACTAGTGTTGTAAGTCCAATGCCAGAATTTGGAGATCTGAGTTTTCTTTTCATGGCTTTTATTCACTGTGACTAATAAGCTTCCTAATAAATCCTTGCCAGAC + BF0IKGGHHJJHKKK@KKGKJKJJIJJ9JJ@EKJHJAJE=K,KJ=KK1KK6KKKJK'CFIHKIHJ0HE;IJC?(;;F@IEF5AICFGBB0IIJJIEIEKIK9IA,HJII>FKKJCK:G?HJKJJD7KJHKK6KB$IHAHJ-I=?:JGGKAIEK'ID,K&KKKK77-H9KKBKKKJJKJKKKK?KK?KKFK5KGFJK@JIK2KJK?KIKKGKK>JKKGF2GKKKKK'K'FHJ@KKJJDJKKGKGFKKJ5KKJ;GGKJKH%JKKKKIK>KJKK>KKKKKKAKKIGJKCHKJK7DKJKGJBB>KJKJ/KKGKJIEK9KKGKKKKFKJCKJKCJKKKFHJCKD*IJJJKIKKIHKJ,H<@H:EIFIKKKKJJHAG?0IKIJJKKKJKKK@HKIKKKKJKKFKIHD>#KKKKKKCDKKGKKKKIGKJKKJB-IJ-IIGIDJFD3FKEHF2KGKHJFIG@F?KJI-JJJHC=JDJJAIJFKJIKKKIKDJFEKJHB$EBE9=KK=JKKCKKKKJ-KG?JKKKKK8KJKGJKKGKJKJ?CJ4AKK%DEJKIAEKK@GFIIE4JKKGKKH:KK5KJK4JKKHKHKK/I'IJJFBBHJGKKJK>JKGKJFKFFKKJ9HJKKHK?>;BJKH&CKKKK@;FIBKJKKCKKKIKIHKFIFK%HB:FH.9B3KIKJ2KKGHJKHIH4IJKC&JJJIIHH;KKFFJJJ*66GIGGEA>BJ4GKGKI=BH=EJFKJI>#FH@K*J9H:KKHAKD6GKKI6K5K7>,CIEAJGJJKBKIKJ@G2JFJE<'GGGFK/JICK=H@;??JK;7KKII&J;>*I>DEHJDA)=E5GI%IKI:KJJHFEKI+KJJKJF@K=JKJKKGK5IJCI,KKKKDK,KGBF+H@JG@KCIG,KKJIIE@K>KKKDIFE?JJKJ?KKKEKKKGHD?CHE'7IHAJ@=@FK(J@K;JCGIKDIDKKJFG*KKKFFH9JKKKBKIKI'IKJJFKKHKE$8HKK6KKJJ@KKFKJIJK.KJDKDKFGFEIKE?DGJE@KJHKJ@H=JFIJJBGIG?KHJ5J6I@,IKJKFEKKKDK8JHHHJJIKJJKJJHJKJKFHKEH9JK&KKJKBGJKCKJGKHKKGKBKGIKKHKHK>EKGBKKJKK?K:KKJJHKEJE1IJHGIGIJKKKCJG+==<:(CJIKKE??JJEHIJHKJAKJ/JKJKKKKJKJJIHJCC>CJ:@BEKBKK??A%IK?HBD2KKJBKKICBJJKK2KHIJJKKKJKI;AFH9KJGIIFJKD3H@FIJKCFKG0HFD@3C=G3=GAHIIKA8IKH%IJKIK9KJKIKI>KKKKKIKGI.KK0KKDKKK>KJ9K?KIKKKKK+KKJ@JJAJFKJJJKJII:IKEKDJKKHHCKJKF76KKI=K@KK4JKKKJKKKKH)%&HD8KKKJCH9KI8KKKKGKKJKKKKKKDKEKKIKIK=KBKKJJJ7KKIBKKKK(KE=KJ @rCer/312/2688_59_CCS ATGGGGGCGGGCGGCGGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGGCGGGGACACTCCCGGGGCCGAGGACGACGAGGAGGACGACGACGAAGGAGCGCGCGAGGAGGACGACGCGTCGGGAGCGGGGCCGCCCAAGGCCGAGTCCGGCCAGGAGCCGGCGTCCCGCGGCCAGGGCCAGAGCCAAGGCCAGGGCCAGGGCCCGGGCAGCGGGGACACCGTTACCGGCCCAAGCGGCCCACCACGCTCAACCTCTTCCCGCAGGTGCCGCGGTCTCAGGACACACTGAATAATATTCTCTGGGCAAAAAGCACAGTTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCTGAAGACAGGGGAGCAGACGCCGCCACATGAACACATCTGCCTGAGCGATGAGCTGCCCCCCAGAGCAGCCCCGCCCCCACCACAGACCGGGGCACCCTCCACCGACAGCCCTTGCCGCCGCAGCACAGCACCCAGATGGCACCTCCGGGGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGCCACTCGCATCGAGACCGAATCCACTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAGATTCTAACCTGACCCCAGTGCAGAGGCCCCACAGACCCTGCAGAGCCCACCTCGCCTTCCTGCCGCCCACTGAGAGCCGGATGTCGGTCAGCTCCGATCCAGACCCTGCTGCCTACCCCTCCACGGCAGGGCGGCCACACCCCCTCCATCAGTGAGAGGAGGAGGGCTTCGACTGCCTGTCGTCCCCAGAGCGGGCTGAGCCCAGGCGGAGGGTGGCGGGGGAGCCTGGGGGGCCCGCCGCCACCTCCACGGGCATCTCTGAGCTCGGACACCAGCGCCTGGTCCTACGACTCGGTCAAGTACACGCTGGGTGGTGGATGAGCACGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCGGAGACTACAGTGACGAGAGTGACTCGGCCACCGTCTATGACAACTGTGCCTCTGTCTCCTCGCCCTATGAGTCGGGCCATCGGAGAGGAATATGAGGAGGCCCCCGGCCCAGCCCCCTGCCTGCCTCTCCGAGGATTCCACGCCTGACGAACCGACGTCCATTTCTCCAAGAAGTTCCTGAACGTCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCCGGAGTCCTTCGGCTGTTCTCCTGCATCATCAATGGGAGGAGCAGGAGCAGACCCACCGGCCATATCAGGTTGTGCCTCGACACGAAGACGAACTTGAGCTGGAAGTGAGATGACCTCTGCCTAGTGGACTCCAGCGCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACCGGTGCCGGGGCGTCTTCCTGCCTATTAACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCCAGGCCCTGGCCAAAAACAGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAGGGCAATGACGTCCTCTGTGCCGCTATGCAAAAGCATTGCCACCACCCGCCGGCTTCACCGTGCACTTTAAACCCACCCTCCAGCTGCGTCCTGGAGATCAGCGTGCGGGCGTGAAGATAGCGTCAAGGCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCTGTGGATATCATCCAAAGAACAACAAGTACGTTTGGGTTCATCACCAAGCACCCCAGCGACCACCGGTTTGCCTGCCATGTCTTTGTGTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGATACAACCTGCCCCACAGAAGATATCTACCTGGAGTAAGCCGTGCAGCCCCGCCCTCTCATCCCCGGCCCTCAGGCCAGTGCCAGGACAGTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCTACCACAGGGATGAGGAAGTGGGGCTGCTGGCCCAGGGTAGGGGAGGGTGGGGCAATGGGAGAAGCAAATGCGGTTTATTGTAATATATGGGATTAGATTCATCTATGGAGGCAGAGTGGGCTGCTTGGGGATTGGGAGGGGCAGGGCTTGGGGGCAGGCCCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGCCCTGCCCCATCCTGGGCCTTACCTCCCCTGCAGGGCTCGGGCGCTCTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCTTGATGAAGCCTGTGCCACCTGCAAGTGCCCACCCTGCCCCTGCCCCACCCCCACCGAAAAGCCGTGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACGTGGAGGTGAAGACCCCGTTCTCAGCCCGTCATTTGCGGACTTTGGGTGGCTCCTGCCACTGACCTCACCGGCATGCTGGCCTGTGCAGGCCTAGGACCTCAGTGGGAGGAGGAGCTGCCGCAAGGCCCTGTCCCAGCAGGAGGGAGGCTTCCTGACTGACACAGGCAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATAAAGTGCCATTTTCC + (,-*)-(+,((**#**'+('$(''(,%,--*,&,)--,.-.,-,-*++)*()-----(+*+,+)+--+$+,,$)-)+()-+,&&+%(,($%#+,)&((*,(+('%$()(-*$+*,--+%,)),-*----+)((,(+(&&&#"%),-+&-,)*&,',)%'&'('-)-(*-+-.,-,-)**',-.-*(+,(+)'-+.**&'+-).+),+*-&*,,,.,)--*.,'*-(,,((#$'&'(*,-*--)&$,-)-**-+++&,((,*'+*+,.**-*-+(%#)(-)*-..++,,*--,,*(+,',--+''',-,--*-*,&(*$$$)*)'('$&%('(,($")((+-++$)&',*(,)+..*+-*+-))',-+*-++((&''&,.-,+),*)-,--*#*)*+.,-.,$$&#**'*-+*%%**&&,,--+,------+(&+++)$+(+--,-..*',,,--)),&)+*+++&(%+&)(*'$*-),.,(,-,,,)%(&,)%&*)-,(,,)*+($)&,*(,-*-),))')+*+**(##()+,'(+)+-,,.+-,,-----(),-)&'+%$&),+------,&-)--)+.--'('+'%*'*&'*,))*(&(*)&)))%+#,-)'(-,,'%&%&&'%-%+(,...*+&,,-**('&,--$#&()-..-,-,*'))++'((''#+-,,-.*$++(-***,,,'(,--.-.+'()-,-*----+(,(%+'+'+%&,,&)+)&$')-,-()().(--+(+*-.+-.,*&&((''&(#'-*--*-,(%$)')$)()---+**$++(+'+-)%,+-*+***&*,*(+))%,*$)(&'#&(&+*+)-*'+-+--,**&$&-**-++'%$%(%(,+,,'(-,),(&))+&+,+(,)(((((')+'---.,-,')*$*+',(+*')*,)**'((,,+&%)(#$(*&'*$,*+))))+(,+-,*)('('+,&-,,),&&(-*&((*),'+$,+-++**-+,'**--+(+)((')+--(-,),---*+(*))-+--,,----,.+---,-,*)),,),)+),-,-*)+&(,)*--,,$-('&')')+&-,.*-(&)-,-+(%''&'#)#&'#),....)---()--,--,)&$)-+,,%--+*+-*)'),,,',%&'*('*),,,%&,.+*##*&,.-,+'**%),&,.(,,()*),.(*%*((-.*-(&&&'+*+(---,%#,&*+-.)''$'--.---*---)&*-+-+*%&-)()(()&+--*'**)'*,.---)*#')),+%,,*',$+-+,),+*,(()&,&,(+(-,**(+(,,,-*,,)($'&%(,*+#')&(($#'$%)&$'''%'&$'$%'))(($((&#'$'))('&&$%(&$)$#$'))('%$#(%&$%$())&())((%&&$$('&$)$$%(((%''$"#$$())))(('#"$$&#&%#()'%%)(%$('$()'%)(&(&()&&)')))))($&%%(%()(%&)()&'&#(($'&(%(%$&(&%#%#&'''((&%#$$#'%$('$#$)(()&$''##()(())%('&'(&'%&(()))('#&'%')(((%'))('($%$''#'&&(()))(%&($$&$&(%((&%&)##%$&%'('%$%(()))((%'')%'(()&%$(()))&#&%(&'&'(&$$#&%%%#((($%)&&&$)(&"&()#%$%((%(%%(%($()))()())($(%()))'&'&())&))))))&)')))))'%)(&)())&'(%()('$($#))'))&)&%(('))'(%()&&%$%%$%'))&((&(%&)%()'(%)&&()(())&(%((%('$"$&%**&,.-..)%((&+*$+,+*&),+),-,)(,,,(+'&$+,++---.--,,-.)---,--*-,+'##$&$#+'+-,+)$(()(-)--(++,),*+-,)(*'*&*-),(,,-,*(*,,,+')%"*-*,*+#'(*-)+-+-+)(*',-.+-.-*-,#+-+'%,+---,-.--*%(-',*,((++)*--)*+)+&+$-,+(('(,)%#(,,$,--,.,)%&)'*,#%,-*(-,..,,'##&'+(%#()-&)(*))%"$+*&&*&+%,,,-)*)++(++()*,-(+%(*(**--*-*(-+',((,)*),*-+')#*&)*+''&$&&'%##')(%&%%,-'#*+,'),',(-.+,*++#,+-,)'%+'&)'-)+'*,(,(*'*,.+-.+(+--(+(,--+($+,*+&+),(*-.-,*)#-+,(,-,*('&#$&#&-,'*,-*,(----*--(+-(,--.+,(-,)+,(),-(----+$+,-(,')&(+,**,'(-,))')+%,)-.-,+,*%$&%&%)(-,-)-),-*&$%++*$(-+(+))(,-),(,)(,--+-*(*-*'(('().))+),+-(*,-+$"'(%+((&*%-.-.-(*)'+,()-,$+-),-)())'%$'*($&+(,,--+#+,,-*$,.,-,-&'&'*$*-+))**,(())-)--,(,.+--,+)-,(-+*,,)(+&'%$&++,))()&),-*%--+&)*+$')(*-),)--*+',,*+-+-,&*(+,,'+%+')%*-.,,-),(#,&,,*+*)---+),)#*-++*$')$($$&,.,*&'(''$&',(---',%'()'(-**-*-('***$-+ @rCer/313/0_1361_CCS CCTGGAGCACGCGCGCGAACCAGCTCAATCAAGAAGAAGAAGGAAGAGCTGGAAGCCAAGCGGCTGCAGTGCCCCTTTGAGCAGGAGCTGTTGAGACGGCAGCAGAGGCTGAACCAGCTGGAAAAACCACCGGAGAAGGAAGAGGACCACGCCCCGGAGTTTATTAAAGTCAGGGAAAACCTGCGGAGAATTGCCACACTGACCAGCGAAGAGAGAGCGCTGTAGGGCCAGCTGCCAGGCTCAGGCCACCACCCACCCTGGCCTGGACACCCTCCTCCAGCCCTTCTGCACCTGGCAGCCCTGGGCCCCAGGCCTTGGGACGTCTGTGATGTTCCCACCTGCTTCTGTAGAAATGTGTCACCCAGAGGGCCTGGCTCTCCCTGGGAGGCTGGGGCCCCTAAGCTCTAGGCTTTTCTTCCAAGCACCCAGACCTTCTGCTCCACGAGGGAAAACTTGCATCCTCCCTGCAGGGGGTTCAGAGCCCAGCACAGGGGTTTTCTCTGCAGAATTGAGGAGGAAGAGGCAGCCTCTGGCTTGACAAGCCTTCTGTTCTGCCCAGGCCTTCCCACCAGGAATCTCCAAGGCTCCCCAGGGCCCGCTTCTCCGCGCACCCAGCTCCTAGGTCTCAGAGAACTCCCCCACCTGCGATTTTACCTGCAGCCAGCAGAGCTTAGCTTCAAGGTCACCGCCTCCAAGCACTGAGGGAGGACGGGCAGGCAGACCGCAGGTGGCCTTGTTTGCTGCCATCCTGACCAGGTGGAGGACACTAACAAAGACAGCTGTTTTGGGTGTTCTCCCCTCACCCATGCTTTCATCATCCCCTCCGCACAGCGCCACCGCCACCCCCCCGCCCCATCCAGGCCTTCTAACCACACCTAGCCAGGGCTGCCACATTCCTGCGCCCAGAAGTCTGCAGCGTGCCTCACAAACTTGATTGTGCATGCAAAATCACTGGGGATCTTGTTAAAATACAGCTTCTAACTCAGTAGATCGGGGTGGGGGCTGAGATCCTGCATTCTAACAAGCTCCCAGTGAGGCGGAGGCTGCTGGTGTGAGGACCATGCTGTGAGCAGCAGGGCGTGGGTGCCCAGGGCTGGTATGTATTAGAAATTATCACGCCTGAAGCCATCGCTGGCCCCCACCTCCCGTGGACTGATGCCCCAGGGATTCCCACCCCACCTCTGCACCCCAGGTTTTCTTCATTATCCATCCCACCCCAGACTCCCACCCCCAGGAATTCTCCATGAAGACTTTGGCCTAGCAAATTGTGTTGGTTATGTGAGTGTTGTTTTAATCAGAGATGTATGTGATGCCAATCTGCATTCTTCCAGTGTGACCACACTGTTATGATGCAAATCTAG + S%(()'(%#%%$#$%$+12121-*10%/0-0/1/5..600634.6542.-06/43,3)/*+-/'2462/.(()/*+,1-,,,/10-0/-0(00/,110.1-10111+.1*/),/01+0110(1100,-',10201,1'012/0.-/*1-.,(./1/,+,/.20+0%/./1*.+,*(***))*-.*./--*&.+'+,00+'.--0111/%/*)'*+(+,10''')%01%)11-/1+1-*-,*11,1%..*1/,10.(/,*/2-1.).-01/20/-00/2+-'-**20,-.012,'00,-)11,%(,%.-+-1/.2+1,1/),*..++*,.)-&.%/2+&.*/&/2,+10.1,,1-+-*.,)#,-,00*12+10-100+/&/.//20/+,+0+000%/./-.2.*+&*)&.+-12,&,1/-.21--)1-''&$$'0.+11/*0%&,,%.-%+,-+,.-'*0&0*%.01/1-'+.0/,1111-,+2/$)*'-+&-,-$,0.//*(%-*)&+$.-,*.'-1++'--.1,1)1'*1121-11,0-20,--0//1.1'*)&+/1/2,.'/*11+,1-1211,0--,-2,0*,(0111,22)0-.++10.,-/.1,/*-0,,)--00,-21--,*010.,+%$+++-00211.11&.1,'&01--,0)1,1111.+*%,*.1-0/,.-21..%-,&.001&0.-/,+.)"'%'&,-0)1,),%//-,.(/,/112-&-/2%*'#*,.*&,+/-)).01,,1-%-.&0-&0.1-0,-210221.-(-1&0&/0.+02'.)//.(0+(..0(./)010-120+0.,0#-,,/020--10-*'$-*./-'0,#*('(+/(*111.'(,///.2/2,($.+.&.-,2-/,,.,*-..-'&'+0.+)..%--*$-/00,2+./(+1.,+$//,/)-.,*11/02.102,.*0(,+&%(-0//-/0&0//.')(00(1'././01&0*,).*%(&).1.+0,,/+"--,)%*0.)(,/010216165+'1*./01(/3-2.5.-$,2,3352650+131/1-2,/+)0'/'&)().5-5121*.244.+1-%,+'-3//0663)43,-+2/41304250/%22%0.232/.++/1-5/)420-30,04$/0/.,'1,'35/**10%,+121(3132-243%((+0..2440$4-202/+&0233%))345/)-..*33))200,33-(300./4*&,442(35300(,&,(*,)(1155+.0.4&..'3'1.144(0**.+-/+/02,2+-/00*,+-*/+&*++&+(*(('&$&.0,,)//(*+$+(1)''*)+%*))*$/()--'*.*1(0+)'+&-*+&'&++(//*)''% @rCer/314/1517_55_CCS GGTATGGCGTCCGTGTTGGGCTCCCGCCTGTGTTCTCTGGGGATTCACGTATAGTCCCACCATCTAGGACAGGGCTGGGGCAATCCAGCCTGAGGAAACGTCAGGGGAAGGCCCAGGATCCACCGCGAAATCCCTAACCATCCAAAAGGATCCGCGCCATGCGTCAAGCCTGCCTGGACCCAGTGGGGACATTTAAAGTTCTACAATGAAACCCATCGGAGATGCAAAGAGAATCGCCTCTGCGGAGACAGAAAACCCACAATCGAGCATCATCAACTTGCCAGATAAACAAAATGGTGATATCAGAAGAACAGATAAAGTTGCCATCCACCGAGAAAGCAGAGCCGCCGACCTGGGCCCAATTAAAGAAGCTGACACAGTTAGCTGAAAAAAGCCTGAAGAACACAAGGGTAAAATGAACTCCAGAGAATATGCTGTCTGCAGCCTTGATGATTGTATCAATGGTGTCTACAGGTGTATCCAGCAGCTCCGAAGAGACAGTGACCAGTGAGAACGGGCCATGATGACGATGGCGGTTTTGTCAAAAAGAAAAGGGGGATATGTAGGGAAAAGAAAGAGAGATCAGACTGCTACTGTGTCTATGTAGAAAAGGAAGACAAGAAACTTCATTTTGACCTGTACCTTGAACAATTGCTTTGCCCTGAGATGCTGTTAATCTGTAACTTTAGCCCCAACTTTGAGCTCACAGAAACATGTATTGTGTGGAATCAAGGTTTTAAGGGATCTGGGGCTATGCAAGATGTGCTTTGTTTAACAAAATGTCTACAGGCAGTATGCTTGGTAAAAAGTCATCTCCATTCTCCATTCTCAATAAACCAGGGGCACAATGCACTGCGGAAAGCCACAGGGACCTCTGCCCTGGAAAGCCAGGTATTGTCCAAGGTTTCTCCCCATGTGATAGCCTGCGATAAGGCCTTGTGGGATGGGAAAGACCTGACCGGCCCCAGTCTGACATCCGTGAAGGGTCTGTGCTGAGGAGGATTAGTAAAAGAGGAAGGCCTCTTGCAGTTGAGATAAGAGTAAGGCCTCTGTCTTCTGCCTGCTCCTGGGAATGGAATGTTCTCGTATAAAACCCGATTGTACATTTGTTCAGTTCTGAGATAGGAGAAAAACTGCCTTGTGGCTGGAAGCGAGACATGTTGGCAGCAATGCTGCTTTGTTACTCTTTACTCCACTGAGATGTTGGGTGGAGAAAAGCACAAATCTGGCCTACGAGCACATCTAGGCATAGTTCCTTCCCTTGAACTTATTTGTGACACAGATTCCTTTGCTCACATGTTTCCTTGCCTGACCTTCTCCCCACTATCACCCTGCTCTCCTGCTGCATTTCCCTTGCTGAGATAGTGGAAATAATAATAAATACTGAGGGAACTCAGAGACAGTGATGTTTGCAGGTCCTCCATATGCTGAGCGCAGGTCCCCTGGGTCCCCTGTTCTTTCT + %%%$.-*.'-0.512938;55;-8705:3<><3776%4?;::4&33&32989,-201&2,09+62=5:4<8461(24368548=7>;8;075+8;9:5342'0*11<0798,5/65;;89;8<<:27=2582622:<0=883/%547796:<510;27940,-*0-2/&332162*3655:96989=<;<<86()/&(.1484/3$441;:>::1=9;98:.*4984'75953//-69=7-41A?:5<>.:6-:>>6B9.8@@9>=<84;3A?4=5+%6+4=B4;><@.B@6;678?99<362==:5=@==6@4997<=94@9=AA>3;=@8:64:=B;3><@+99(D9A;;9)2=998;?A?====::?9B>,78<=6?;A9D79D9C5<3A9?B?C>6;9679.8@E?4-<+220237?;88&3;6:0155<<3;9;<21160,;;5;47977=3;/9=C754:/9>6<4.@BA',8>>@<;6?@??/6:=526:1:;77?96>@?6?B9;:6/28;9@;>:@8@74<98<7@?@99>70+324&=409:3.21;8?=::6:<2>0:8-:<497=:A<13:?&9<:928;3899)844B@4@0989%:78>C>:?<9=6=>3>:6=54=>&C=?6;A;7=::0*0164-7&;3/6@A2=>;>-<;:>67;;61;20:689868>?,=8A?=@@B;6<121A:?<1880<.><>1?=>6BA6A:99,69103/79/064+7412A@B<747,11,:=;/6<27=,35(<3674@608;/694*33'88045&::=><;7>77>.>7>=.?/?<=/63=78:-<6;;25:1.@;=:A=>;;705/*2+177<67949/617924<1;783638651.-6738><;@4?B=387A@75;8@.5966?A8:<48<:<670/3:3<@?:=11+4:;>5:B?6A:;7<4?4<=6<9.8-&/'+%*/*269$,2,8>6-8-98.3:<1536,1689;69<:350.814/90.1988,6*81<8;<@/@19@;@>9%3=<=5?:@==29:;71,26=8,7:;6?-*;C743:;5?<64*3*,7#+1,/-9611+3/1(22&233624))/057-/954796,/(-1.*-2'%,-4&)835,&/1+.*2503/-2248+/.57)29894113:538418:9645335543*51%/:2+,24:43/66,-5;48:341::45:885477751+//-'375*19564:910102&79 @rCer/316/25_2184_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAAACTGCTCACTACGGCTCCCCTGCCCCAGAAGTCACACGGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGTTCCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGACGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATGG + >=2>826:7,838*7(348-84716:<:28/<72>9(97>=404:580:**-661))(0085*'/-21)41.871390,571@4/839*.)::3505-/78?1<6571<654*573).49.3<>=51=88@3:352<.:5>1(:8;*:5,0/1:66:B9-<:77:989:A>9B+>@25.?@;<><><&4/'+),008;=8'1-02282-972867,75@8?:90<:6@:=86.363=7A3663.:4/69%036;:=6=8=-4-'-1)%/0$%;9;5@6554;5/0-20)/4;@4B8>3?CCF>9:=-:;?-:=29=;C4ACB?=16@?<>1;>>DAD2=@A;C<7987BB?=;5468?;<567?89-3=@<)6@==@?:04;974+9:1=;CFAD73=;::@9?AB)>E8:>3>AE?@<=36(31'770-47:,;C@AA96A58<<(:56=/>:5<>?9/C<8?:7/44758C@7CA?;@>1:5A9A;;><=)-.41.9)27928=7405>C>(,&77/>83>@<88=AEF?;@:<9087570>@@B2>=C1;<@?%<1@*197.@6>3>8:?735BGC<8;?17?@B@?CAD9@EFE8><;93=/38BB=DBAE?@C@=692.33>=68>3?<=84;=?:@:3D24(C?2=38A>;6<6@2>:-:)<77>7=,035:9;5+4)<54=;-A<=;AF?;6E@@A4A8;>B?@5099E@82;-89561,;7ACDEA;B:;:9B8B>@;DGC91;;>@AB5=8>6$87*236;DCD5FG?)=:=7/<>@;=A$'@EEB@*4>8=FEBFE7:CEDCF:<@F@DC5,10GEICAD?04;>:=?@EFI*@C>;DE>ADCCA:>8609B>==BEAJHG:<:9C=BABG?7B4FIG:@D@A>'@A>7@779>HE?FCDD=;CD7?0<;(*:9E@C97@=<&><:;65G=??6=4-CFGB@:?D9E/:@F<;AE6HB@=D:FFB57AE9E;:A>H?C1@>DD7DD2E?A@AEE;=A8E=BEAC:2?2@=D=@DAF>BC9?GD=BDB;52B<;BEB=A?DBHHG8=>AEDIE4F:<@B:7:A>@C8@>H@7;HEB=6C>=6@IE>D>E=1<5;;B=85><;8?6?CC=A9?=?B:@DCAEH@H:1CFB?CG,B@E?8@A5IH?C>;;<8DFI?@:BCCECEB1D;I?D;>DCEF<9=E@=;C?F;FFHADH?B-<0=A<<;8>DCB8EHIGIDE;?@@?/=1>?9=@EFHDF:E3CC?DFDIDF8-A@?A9HCC>H3=6<0?@EDD8DBBGBE>>BB>7@F?=FFBF?GIE@E?>DIE=<(=HHD<4;=:<0>;;?CCDIC0BFC3<<88>:?ABG6DC4IHF7B/DC@;>2:B>CED=AB>G1GFD9D>E6D;?3:FDIGGDH>86CF3=68?;;DADBEA?:EE<=@E7ABA2D8B799:@890@?,><=C>:CA@6/'50<8:=D?799=CEFD=@B?9?5<;><79=EB>A;=:AED<>2=EGD:F9:AEBEC+>7>>A;E>@CBHKGFA9EGI>KEKEKJKHKIEKJCIGBGIHEBHHKBKIHGJEIJIICGCJJJEKAJHJKJJFHBGJI@GEKKIJJHIJFCJIKKFGKAJDEHHF59FKJJCIKG@;IKJI.JIHHFIFG:B13GJAKEK?@IJHJHEHJKAA9GIKJHJGGEFI6KKKIH@KJICHGBJI:KJHJJ=JDIHK?GIIBI5JKIGHFHHACCHJHEKGGJ?IJB:EIJBBBKKHHKGEJFAFGHHJKIJEIJHA?FHKJEKFI@K@JJ8IBKI:EKDKJDJKJI?KKJJJCCKKIJJEKIHIJ=I@:KAHFKHKJKJG>GHG=IFB;CJJI>G9HHIIIJKGFHCE?HGHIJHG4JFFGGKJ41IH?HI=IJGFIIIKJ>KKKEKIJ@FFKKHJ6JJDJGIJIJG@IJGD>IFHKIGIIKKHKKCGHH>>7GFFHGEJKGFIIIEIJH?FFKHF?IH<@IA@GFKJJHADJJF:JCI8D8JCIEHFKFIFJH=JIJ@IGKGIKGJHCKDGEFCG<>EBHHKKJBG?JIGJJ%HIIJDAKFKGDCHH@KJK?KJJIJIDKGKHAFIFK?KIIKJIJ2KHJKKKDKH=KKKKIFKDIJGKJJ@KIEHJJKJAIIBAII)GIIGIHIHGBGKIJKGJJIHJ>HKKJKJKJKIJJJKKKJDKJHGIFKI>KKKJFKJKF&HKCKIJKKGIJF:JGIKDDKHJCKDGGIKKJKDKKKIGJJJJKKH2JKHJ2KKJKKKKII?KKKKKKKKKKI9;9;8+182.43549895=25;18:5:12:=976884,$10*+5<495=/1642(3::7396:7=9;698,)8199<>89<.13:40.+9?9?32=8836<>-?9;<;=:3=:97/.5;%7;83-:;3=>;:85>8>91;:>;<:>;542742/*/9721$3**5<:2=92935;+<=:96%:8;;<;<5:1:49887:9&22.39668>7;>=;4598)997+('-088)33:;7:69=;;>3<6?;:;7<>5:806;;967:.=01<;9947:99:93:98==95:=96&8<82=4;5>>?;:8477861,56?>>;89.7<5;99-.**6.>>===:418=4/<;>>?<628=8<:777;'>18028>72+>:>>::4734;:7<25<:860<7473==:9::->?>;;9>43:8;/5191;$37=26768;;1/;6/4:44735&5.112/%552942/12$04&1'4/4/4;4:75%16.-5839992167.,55572:220933*5809677:/275694945576084:9::27110'16/;27397.'01539--,2+979713.5*1:219655681-345:.0.6/2743582/2059543941-2:5617'49/547-.729345+.9.*(*,37353:93:5,5633'555:956971;8:/60-8,47/84954303)368::2327786&95:7:::725-86:722%86553547/68::8:66199:51064'6.323431765%/*3219:39897-06959949:8+7/97794663035635;;63;698(4)199;5247.:956.395653,+507:/7:8431752+3978879309/1871/220$6.3+,&2.954-/96,*7'9:787:74-.55.4562--.7&98/12&2:1.)'321.-.78/1.7:9277:;7:84*3%+/**-246453/./-.#25587/656:26463/831590,/+9:59/584344%947:0687/)5'9:921768802+%-82&35),-::255138'16497701'9:20055486:32$1527-57043'3+4-5978;33(-1-52.*5320(862:8676777250,/4/5$0--4:1+:266478758763203(3/76:6:77706,3,..1/,3'35/03935:60/3*/030%651066037*471+,6935833/594706/621726892*177-516/&,5843,:22.5./2/63435698442035-&)//-,*5754)/1+.2*95:450*2/:++0%85:163523/(816403612.+417868556'2144-40564544-116/$*$-,/34;448/1/665.4264/5465-1.45216+,3'86721/44288:5-310/976:68418/..535/636679.2285878:8512,2.45,./&30-22+,%04656.764344526,-/+63*/53447-84(-30)+,4/1+03/.12/:5745838/169746406-90.2("487/200/+358:8677464869.5-274098877/15*-441)50/11./1.)4405.+1&37733/3010/(976+7/.,8-64742.8305186-5+369597357/667,6648/476/4..*(/+16*4442954/2.51024(.06)+/-030*/(+,/4+250344+*132,&,(0&)*,(&&#'.*02*1+40/334/.1033&*0/0*0,2..0/11-.1-+%',-&1321.*1,/-0&2-2/+01,).&,..-/21510)21/1+..30,+/*,*)&/0+1.4-5&,/..&)%%-%,,/,.02%),*4,*.0001(-//*0*/$(11)'%.3-&0-..,312+/-210-%..(/%.1)-/0*(*0'2335/.-+,)-.+,&0++**,-&..'.(),)*,,--,&(./(.--/)'(*).-''(++')(*,)*$'(,+)*&)&%#,%*,+-)$+**$(,-(&()(')'+(',*(*)"'#'-,(#,*),-+--(--)++(-'*(%&#,+(**%(),''#)&),-**))'',''" @rCer/323/2812_61_CCS ATGGGGAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGTGAGCAGCACTACGGCCTCCTCTCCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCCGCCTGCTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTGCCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTGCGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGGAATTTCGATGGCTCTAGTACTTTACAGTCTGAAGGTTCCAACAGTGACATGTATCTCGTGCCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCGAACAAGCTGGTGTTGTGTGAAGTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATAATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAATATACCCTCATGGGGACAGATGGGCACCCCTTTGGTGGCCTTCCAACGGCTTCCCGGGGCCCCAGGGTCCATATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTACCGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCCCAGTGGGAATTTCAAATTGGACCTTGTGAAGGAATCAGCATGGGGAGATCATCTCTGGGTGGCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCTAAACCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGGCACCAGTACCACATCCGCGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGCCTAACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAGGGTTACTTTGAAGACCGTCGCCCTCTGCCAACTGTGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTTCTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCTGTCAAGCCCCTCCTAGTTCTTCATCCCACTGCAACTCTTACCCCTCTCCCAGTTGTCCCAATTGTAACTCAAAGGGTGGAATATTAAGGTCGTTTTTCTCATTCCTTGTGCCCAGTTAATCTTGCTTTCTTTGTGTGGCTGGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACCTACCCTCCTTTTTTTCCCTATCACTGAAGCTTTTTAGTGCATTAGTGGGGAAGAGGGTGGGGAAACATAACCACTGCTTCCATTTAATGGGGTGCACCTGTCCAATAGGCATAGCTATCCGGACAGAACACGTTGCAGGAGGGGGACTTTTCTTCGAGGTAGCTGAAAGGGAAGACCTGACTTCCTCTGGTTAGGTTAGGACTTGCCCTTGTGGTGGAAACTTTTCTTAAGAAGTTATAACCAACTTTTCTATTAAAAGTGGGAATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTTGGTCTCTTGCTTGTGGGACTAGCCTGGCTTGGGACTAAATGCCCTGCTCTGAACACGAAGCTCAGCATAAACTGATGGATATCCCTACTTGAAAGAAGAAAAGGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTATATTTAAATGTAAAGACAAAAAATTATATGTATGGTTTTGTGGATTATGTGTGTTTTGCTAAAGGAAAAAACCATCCAGGTCACGGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGAGTGAGGGAGGTGGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATTACCACTTCTGGGTTTCTGCCCTGCCCACCCTCTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTAGCAGTCACTTGATCTCTGTGGCTTTGGTTTTAAAAGACAGACACTTGTCCACATGGGTTTAGAGATAAGAGTTGGCTGGTCAACTTGAGCATGTTACTGACAGAGGGGGTATTGGGGTTATTTTCTGGTAGGAACAGCATGTCACTAAAGCAGGCCTTTTGATATTAAATTTTTAAAAAGCAAAATTATAGAAGTTTAGATTTTAATCAAATTTATAGGGTTTCTAGGTAATTTTTACAGAATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGGACAGGGCTGGAGTCAAAACACTTGTAATTTGTATCCTGATGTCTTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTATAATAAGAAATAAACCCCACCTTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAAGTCAAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCCAAAGGAGCACTTATAAATCAAACCT 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rCer/325/25_2032_CCS ATGGGGGGACCTGCTCGAGGAATGGCGCCGCCGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATCATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACAAGCATGACGTGGAGAGACTGAAAGCCTCGCTGGATCGCCCTTTCACAAATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGTGCCCAGGTGCAGATGCAAAGAAAGCATGTACCTACATCAGATCTAACCTTGATCCCAGCAATGTGGATTCCCTCTTCTACGCCGCCCAGCCAGCCAGGCCCTCTCAGGATGTGAGATCTCTATTTCAAATGAGACCAAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTAACCAGATCTACCATGCAGTTGCAGCTCTAAGCGGCTTTGGCCTTCCTTTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACGGTCCAGGCTCTGCAGACAGCATCCACCTGTCCCAGCAGGCTGACCTGAGAGCATCGTGGAGGAGATTGAGGACCTTGTGCTCGTCTGGATGAACTGGGGGCGTGTATCCAGTTGAAGAAGGACTGGAAACAACAGCGTATTTGTGGCTGCCACTACAAGCTCATGGATCATGTGGGACTGAGCCATCCATTAAGGAGGATCAGTCATCCAGCTGATGAACGCAATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCTCTGCGGCTGCTGTACTTTCCCATAATCGCTACCACGTGCCGGTTGTGGTTGTGCCCGAGGCTCTGCTTCCGACACTCACGAACAGGCTATCCTGAGTTGCAAGTCACCAATGTTTTGTCTCAGCCTCTGACTCAGCCACTGTTAAACTAGAACATGCTAAATCCGTTGCTTCCAGAGCCACTGTCCTCCAGAAGACATCCTTCACCCCTATAGGGATGTTTTTGAACTAAACTTCATGAACGTCAAATTTTCCAGTGTATTATGACTTCCTTGTCAAAGTTGAAGGTGACAACCGTTACATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGCATCACAAATGTTGATCTTTCCACTGTGGATAAGATCAGAGCATTGCACCCAAAACTACCCGGGTGACGTACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTTGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTCGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATCGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCTACTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGGCCTGAGAAGAGGCCCCCACCGTGGTGTCCAATACATTCACTGCCCCGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTCGCTCCTAGCACGATTATATTTCACCTGGACATGCTGCTATGCTGGGCTCATGTATGTTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACTGGCATCTTGGCAGTGTGACGTTTCTGGCTGGCAATCGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAGGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAAAAGAAT + 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@rCer/326/0_2627_CCS GGCTGGGACGGCGCTCCGGGTCCGCGGTTTCAACATCGGAACAAACAGCGGCTGGTCTGGAAGGAACCTGAACTGCGAGCGGCGCGCAACGGCGGCGGCGGCTAAGCACCTAATCGGGAGCCTGCAAGTGAACAGCTTTGAGTCTTAGACAGCTGGCCTGGAGGAGAACACATGAAAGAAAGAACTCAAAGGCTTTGTTTTTCTGTGAACAGTATTTTCTATACAGTTGCTCCAATGACAGAGTTCCTGCACCGTTGTCCTACTTCCAGAAGCACAGATTCCGAGACAACCACTTGAGCAATACTATGACAATAGAGAACGCAGAGCACAACGACAGCGAGCCTTGGCCACCTGAGCCATTATCTAAATGACGACCCCAGGGTAACTCTCGGCAGGTGTGGAGCAAGATGAAGAGAAGATGAGGAGCTGACATTGAAATATGGCGCCAACATGTGATCATGCTCTTTGCCCTGTGACTCTCTGCATGGTGGTGGTCGTGGTACCATCAGTCAGTCAGCTTTTATACGGAAGGATGGGCAGCTAATCTATACCCCATTCACAGAAGATACCGAGACTGTGGGCCAGAGAGCCCTGCACTCAATTTGAATGCGGCCATCATGATCAGTGTCATTGTTGTCATGACTATCCTCCTGGTGGTCTGTATAAATACAGGTGCTATAGGTCATCCTGCCTGGCTTTATTAATCATCTCTATTGTGCTGTTCTTTTTTCATTCATTTACTTGGGAAGTGTTTAAACTATAACGTTGCTGTGACTACATTACTGTTGCACTCCTGATCTGAATTTGGTGTGGTGGGAATGATTTTCCATTCACTGGAAAGGTCACTTCGACTCCAGCAGCATATTCATTATGATAGTGCCCTCATGCCCTGTGTTTATCAAGTACCTCCTGAATGGACTGCGTGGCTCATCTTGGCTGGATTTCAGTATATGATTTAGTGCTGTTTTGTGTCGAAGGTCCACTTCGTATGCTGGTTGAGACAGTCAGAAGAAATGAACACTTTTCCAGCTCTCATTTACTCTCAACATGTGTGGTTGGTGATATGCAGAGGAGACCCGAAGCTCAAAGGAGAGTATCCAATTCAAGTTAGATGCAGAAAGCACAGAAAAGGAGTCACAAGACACGTTGCAGAGAATGATGATGGCGGCTCAGTGAGGAATGGGAAGCCCAGAGGGACAGTCATCTAGGCCTCATCGCTCTACAACCTGAGTCACGAGCTGCTGTCAGGAACTTTCCAGCAGCATCCTTGCTGGTGAAGATCCGAAGAAAGGGGAGTAAAACTTGGATTGGGAGATTTCATTTTCTACAGTGTTCTGGTTGGTAAAGCCTCAGCACAGCCGAGTGAGACTGGACACAACCATAGCCTGTTTTGTAGCCATATTAATTGGTTTGTGCCTTACATTATTACTCCTCGCCATTTCAGAAGCATTGCCAGCTCTTCCAATCTCCATCCCTTTGGGCTTGTTTTCTACTTTGCCACAGATTATCTTGTACAGCTTTTTGACCAATTAGCATTCCATCAATTTTATATCTAGCATATTTGCCGTTAGAATCCCATGGATGTTTCTCCTTTGACTAAACAAATTGGGAGGACAAAGGTGATTTTCCTGTGTCCACATCTAACAAAGTCAGTTCCTGGCTGACTTCTACAGCTTCCTTCCAAGTCTTCCTGACCACCTGCAACTATGGACTTTGAAGGAGGTGCTATAGAAAACGATTTTGAACATACTTCATCGCAGTGGACTATGTCCCTCGGTGCAGAAACTACAGATTTGAGGACGGGTCAAGGAGACATGATGGGCCCGGAAGTTGCTGTGCCCGTCAGCAGCTTGATGCTTGGTCACAGGATGATTCGCGACACTGCGGACTCTCAGGACTACCGTTACCAAGAGTTAGGTGAAGTGGTTTAAACCAAACGGAACTCTTCATCTTAAACTACACGTTGAAAATCATCCCAATAATTCTGTATTAACTGAATTCTGAACTTTTCAGGAGGTACTGTGAGAAGAGCAGGCACCAGCAGCAGAATGGAGAGGTGGCAGGGGCTCCAGCTTCCCTTTGATTTTTTGCTGCAGACTCATCCTTTTAAATGAGACTTGTTTCCCCCGTCTTTGATCAGGTCAATATGTGTAGATTGACTTTGGCAATTCTTCTCAAGCACTGACACTCATTACATCTGTGATTGTCATTTTTCCCAAGGCCAGTCTGAACGTGAGGTTGCTTTATCCTAAAACTTTTAACCTCAGGTTCCAAATTCAGTAAATTTTGGAAATAATACAACTATTCTCATCAATTCTCTATCATCTTGAAGTCAAATTTGGATTTTCCCACCAAATTCTGAATTTGTAGACATTACTTGTAGGCTCACTTGCCCCAGATGCCTCCTCTGTCCTCATTCTTCTCTCACCCCACACAAGCCGTCCTTTTCTACAGTCAGTAAGGCAGCTCTTGTCGTGGTAGCAGATGGTCCATCTATTCTAGGGTTTTACTCTTGTGTATGATGAAAGATGTGTTATGAATTGGTGCTGTCAGCCCTTGCTGTCGACCTTTTCCACAGCAATGGTGTATGCCAAAGACAGTAGATTAAAGAAGAGTAAATGGCTGTG + S!#$##%%$#%$""#$$"$$#$%%$!"$%%$$%#"&($$$(%$'&$##%')$%$&&%&$&$(')(.-)'%$'(+--*))+&*$#%#'(++*+-+*--.-*)+%'++')+)'%(*)"*+)()+---+*,($#)*(%#$,-(&$($&(-),,,*+',-&,*&,'(-&)(,''%+)--,.,(,%'&&#%&#$#&%)%+*$#***++)-,*$)+&&$*$'&)+&%(%)*,+-+,(&+')&)*(++)%###,*,((+.('*)%&)(++'*,,()#&$(-,**-('&&%&%'(()+-,,*,('%'%()*''&()&+*)--*&%&,('%*#$((%&%'*%*$&&'#((&''*',(,'#*)(&('+)*++*-*#)*+#&(*,%+*+''(*&+,*)*+*')**&)'#'()$(*))(&*+(,)$&'(%('))&*,,(+*,',+))(+*)&%%+(+*%#+(*())((+)(($')(&((""(***+--,*(')-++)+--*)*'#''(-+%$#((-,)(#),&'(+)),%%+,*##&$%''*+,'&**.),,')()&))%*%$(&&*+-'&)(+)-*+'+)++&%(),,&&--'(+-,+(,(+*+)+*+++($$"#),-*''*,+-*,$'**)&)''()(+%$*%&(*)$%+#%,-,+'*,,)+''%'*#%)+,)*%)'(&%'$''((%&&($()'%)((#(%,+'*"&*(),*&#')%*),)'$'(*#&*%&%*&&---,,#$'*,-+*-+((&%*)#%())%)%"$##(-,,-(('*+,**)+'+-,(%&+'+)(%++&%)((*+'((%%$*+$'+%,(*''+(&**%''*+()**(-+)+,(&(('&,++-*$(*(,+)))(''(&*&$&((,%$')),(++%$(***%+*-,)$&#%))#((&*+('%$'*)($'($()('--)-+'+))))%+&'*+(%$*+,-,&#+++-+',+)(,,#&$'((')#((*),+++-+*#*%-()('())),*+,'('')*-(,)((,+-(#%&$"$)()--*#+&&%$,,,#**,',#(,,+-,((%%'*#%$"%""'*%&'-)++,%&)+#$#&$&(')*#'$%"'+$,,%,,(,(+%'+,%###*)+%(,+($$#&)*(+'&,*)(((')$)*$#''*+&%&+-*)+((#),-*'+)+)'$)(+)'%&),'+&$)$**,(),%)((--,,*&())'%',---,)))%')$)$,+,),''+)*('""&%&&)+-)--+%(*&),&*$),)$''-(-,))*(%&(+*,''*#$&,(&&(-,++,,',)'#+.,&)(''+*-*)'++***,--(+-*)*'''*--)*%)*,+&)(+--,#+"$'*)+++%$),,(***%,%#&(*%'%$&)#%(')%($#&)'&+&**()$#&'&),--%()('('&&&'*-&*(+*..--+'),*,))*.'&+'+(%,))++-%$*)%#'$,*,++*+,-('$%').)%&$%$'%'*''%)#))'*(*&,*(,..+,'%**.,'*$'#+%)-(+)#*)$%'&%%&)-,$#&&*%'**'(&')+'*&*-,-+,-,())+,*+((,,((*-+*-*&*%&(-,'-+)-*-(%&&,*')''#,+'(&#$"'##(('#&,+()),*)-,(,,,+$(+)((*,*--(-&%%)+(&*'%'')++$($)')'%&)'$"$&,*(*&'''(-*-(*&)%'((((+*,,')),(##%**%*'&&$%''($*&%%)())&))&#$%&$%$(+''()&(),&&)&')))$))%',-,),%+*$++,(*)(-+,,).-*+'()-*)(&"%&%$)''$',*'$$*),&+%-)+&%',(+,+,+%*)'((&$%,+-+-+)#'+-.)/)%(++*,0/-/102%,)+'$%$'%0-.)$,*$$&(''&(./2)0,.01.12+*)%+1,+10,.*0*)$*..-00----.)/,0-%-0)0+/-'&)(-'*))/+,,+.1*-,,+/*0/&*/)*001-0-/*1,'*,-0)-),0-0%,*/.*,)-*110/-1.),-0-/-.1/0,*/&,-++''1-,111*++/&'&-*%*-+/&-*%)++/+1-%+%&&,///,00.(,&+%,('0./0)0/.//-.0.-/+0'//%'$*%--/*).%+110-+.+(0.(./--.+(#'*+'%.1-,-/*1#+(00,0(,,)10&'%-+(...0021-/,),)0//'+/)1-1.0),/.)$)+011-.,$*,/1.,1&%/$'-#&'2--/..*0)%0&+%,,*1-.0.),+%+-./'/0-+%-./00+-10/12,/,/.0//21-11-.1%-*,++&...&-**/)/,(*$**1--/1'../,*/.(.1,++/0--/100%./$+.%+)(.,,#*+)%(&.,%,/11*/)-/()-)+*/%--.)./*%-0-/,-,%-.&.+/...+,,-,--1/*-))0.11-,.*,.,+/-+"$$%(-*-+-,+1,*%''0/.&)'+*-.0'/-,0.21+0***"!&&$&"#&(''++'%+)+(&)*+%(%$)##$%+($((%$$#$$%$$"####$##"#$#""$#$%%$$#$%"$$%%%$$%%%%%$%%$$#$"#%#"##$$%"%$%$%$"#"$##!"%$#$$"%$%%#$""$#$$##%"#$$####%$$%%$%%$$#"# @rCer/327/24_2229_CCS ATGGGGAGAGTCGAGAGTGGGAGAAGAGCGAAGCGTGGTGAGCAGCACTACGGCCTCCTCTCTCCTAACCTCGCTCTCGCGGCCTGCCTTTACCCGCCGCCTGTCGGCGCCCAGAACACCTTCCACCATGACCACCTCAGCAAGTTCCCACTTAATAAAGACATCGTTGGAGGCCATTACCGGGCCTGCTTGTAGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGTCATGCCTGCCAGTGGGAATTTCAAATTGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTGGCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTATAGCAACTTTGATCCTAAACCCATTCCTGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCCATGCGGAGGAGAATGGTCTGAGTACATCGAGAGGCCATGAGAAACTAAGCAAGCGGCACCAGTACCACATCGCGCTATGATCCCAAGGGAGGCCTGGACAATGCCGACGCCTAACTGGATTCCATGAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCATCGTAGCGCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGACCGTCGCCCCTCTGCCAACTGGACCCTTTTCGGTGACAGAAGCCTCATCGCACGTGTCTTCTCAATGAAACCGCGATGAGCCTTCCAGTACAAAAACTAAGTGGACTAGACTTCTAGCGTCAAGCCCTCCTAGTTCTTCATCCCACTGCAACTCTTACCCTCTCCCAGTTGTCCCATTGTAACTCAAAGGTGGAATATTAAGGTCGTTTTTTCATTCCTGTGCCCAGTTATCTGCTTTCTTTGTGTGGCTGGATAGAGATGGGTCAAGTTATTAATTTCTTCACACTACCCTCTTTTTTTCCTATCACTGAAGCTTTTAGTGCATTAGTGGGGAAGAGGTGGGGAAACATAACCACTGCTTCCATTTAATGGGTGCACCTGTCCAATAGGCATAGCTATCGGACAGAACACGTTTGCAGGAGGGGACTTTTCTTCGAGGTAGCTGAAAGGGGAAGACTGACTTCCTCTGGTTAGGTTAGGACTTGCCCTTGTGGTGGAAACTTTCTTAAGAAGTTTAAACAACTTTTCTATTAAAAGTGGATTAGGAGAGAAGGTAGGGGTTGGGAATCAGAGAGAATGGCTTGGTCTCTTGCTTGTGGGACTAGCCTGCTTGGGACTAAATGCCTGCTCTGACACGAAGCTCAGCATAAACTGAATGATATCCTACCTTGAAAGAAGAAAAGTTCATGTTGCTTGGTCCTTGATTTATCACACAAAGCAGAATAGTATTTTTTATTTAATGTAAAGACAAAAATTATATGTATGTTTTTGTGGATTATGTGTGTTTGCTAAAGGAAAAACCATCCAGGTCACGGGCACCAGATTTGTGACGAATAGTCCGGATTAGAAACCAAGCATCTCCTTTTGAGTAGGGATGAGGGAGGTGGTGCTTAGAAAGATGGTGCTCTGGGGTTAGGTCCTCATGACACTTCTGGGTTCTGCCCTGCCCACCCTTGGAGAAGGTGGGCACTGGATTAGTTAACACGTTTCTACAGTCACTTGATCTCTGTGGCTTTGGTTTAAAAGACAGACACTTGTCACAATGGGTTTTAGAGATAAGAGTTGGCTGGTCAACTGAGCATGTTATGACAGAGGGGTATTGGGTTATTTTCTGTAGGAACAGCATGTCACTAAGCAGGCCTTTGATATTAAATTTTTTAAAAAGCAAAATTATAGAAGTTAGATTTTAATCAAATTTATAGGGTTCTAGGTAATTTTTACAGATTGCTTGTTTGCTTCAGCTGTCTCCTACCTCTGCTCTTGGAGGAGATGGGACAGGGCTGGAGTCAAAACACTTGTAATTTTGTATCCTGATGTCTTTGTTAAGACTGCTGAGGAATTATTTTTTTTCTTTTTATAATAAGAAATAAACCCCACCTTATTCCTTCATTTCATCTACCGTTTTCTGGTTCTTATGTTGGCTGTGGCAGGCCAGCTATGTTTTCTCTTGTCATGACAACTTCTAATTGGCATGTACAGTATGTTCAAGTCAATAACTCCTCATTGTAAACAAACTGTGTAACTGCCCAAGGACATTATAAATCAACCTAACATAAGATCTCTCT 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rCer/330/2584_54_CCS ATGGGAACACACCACTGCTCAAAGATGACAAAGACAGAAAAGCCGAAGGGAAAGTAGAGAGAGTGCCAAAGTCTCCGGAACACAGTGCTGAGCCGATTAGAACCTTCATTAAAGCCAAAGAGTATTTATCGGATGCCCTCCTTGACAAAAAGGATTCATTGGATTCAGGAGTGAGGTCCAATGAGAGTTCTCCCAATCACTCTCTGCACAATGAAGTGGCGGATGACTCCCAGCTTGAAAAGGCAAATCTCATAGAGCTGGAAGATGACAGTCACAGCGGAAGCGAGGAATCCCACATAGCTTGAGTGGCCTGCAAGATCCAATTATAGCTCGGATGTCCATTTGTTCAGAAGACAAGAAAAGCCCTTCCGAATGCAGCCTGATAGCCAGCAGCCTGAAGAAAACTGGCCTGCGTGCCAGAAGCCTACAACCTGAACCGAACGCCCAGCACTGTGACTCTGAACAACAACAGTGCTCCAGCCAATAGAGCCAATCAAAATTTTGATGAGATGGAGGGAATTAGGGAGACTTCTCAAGTCATTTTGAGGCCTAGTTCCAGTCCAACCCAACCACTATTCAGAATGAGAATCTAAAAGGCATGACACATAAGCGAAGCCAACGTTCAAGTTACACAAGGCTCTCCAAAGATCCTTCGGAGCTCCATGCAGCAGCCTCTTCTGAGAGCACAGGCTTTGGAGAAGAAAGAGAAAGCATTCTTTGAGAAAAACAAGCAAAGGAGAAGAGTATTACTGTACCCTTATGACAGAATTGTCCTGGATTTGACTCCATCCACGCCCATCACCTTTCTACATTTCGCTGACAGATCAGTAACAGATGATGAGGCGAGGTAGAAGAGACATCCGCAGTGTGACAGAGGGAGCGCGAGAAGCATGACTCATCAGCCAGCCTCTATTGTCTTTGTAATTAGAAGCTTCAGAACTCACTAATACCACTGTACCTTTCATTGGCGCATTACCCCATAAAACTTTTTGAGATGAGGTGAGATCTGGGTATAAAGATAGGCCAGAAGTATTTTAAAGGGCTTAATTTGCCAAAAAGAAAAGTAAAAAGCTAGAGACCCTTTTTGCAGAACATTTGGTGCCCACACATTTGAGGGAAGATGTGGCTTTAGATGAAGCAGAAGCAAACCCTGCTCTTAGGGTCTCGTCTAGATGAGTGCACAGCCTATGACACTACAGGGAGAGGTCAGGAAACTGAGATCCAGCCTTCTGGGTGACACGGGCATTGTTTATCACAGAGGTTCTGAAGTTTAAGTAGCAAGTACATAATGAAGAGGGCTTTAAAAATTGCTGAGAAAGCGAGTCACCAGGGCTGGCAGTAGTGTAACGGGCTGTCCTGAGCGGTTAGGAGAGTAGATGCTGGGAGGGCTGGTGACCTCCATGGGTTTATCTGTTGGAGACTCTTCTCTCCAAATCCCAGGCCTGGCTTCCAGCACCATCCAGCTGTGCCCAAGAAGCCACCCTGGTCCGTTCTCCAACTCTTTTAAATGGTGCCCAACTTTTCTAAGTGAGCTTAGCAATGAGAAGAAAAAAAAAACATGAATTCTTTATCTGGAAAATCAGGGAAACATGGGTAATAATAGGCACTAATAAATATTATAGATGAGTGAATGAGGAAATAATTACATCAGAAAGGTCAGTGACAATTGATAAATGACAAGGAAATATTAATTAGGTAAAACTAAATCATTGCTCTGTATTCTAGGATAGACTTTATCTACTTCGTCTGTTCCTAAGTCAGCATGTTAATTCTGGGGGAGGATCATAAGAAAGGAAATACTTTTTAAAAAGAGTCTAAAAACATGTAACAAAGCAAGGATAAAATTATATATATATATACACACACATATATAATATGTGGTGTGACTGTAAAACTGTACTTTCCATTAATTATTAGCGGAGTTAAGAGAATGATCACATTGAAGTACTGTGTGGACTAGAAATGTGCCCTGTCATCATGCAATGAAATGTTATCGTTTAAACATAGCTCATTTATGTAGAATGAATTCTGGCGGTTTACCCCACGTCACAGTTAGGACAGTAGATGGTGAGATCGCAGATGCACAATTATCTAGATTCCGTGTTACATTTCAGTGTTTATCACTCAGTGGATTTTATTAATATGCTGATTAAGTTATTTACTTGGCCAGTCATTGTGCTAAATAGTTGCTCTTTTGTGTTTCATTGCCGTGATGTTTGAGTGTAATCTAGCATTTTAATACAGTGTTTATTTTGCATGATCTTTAACAAACGTGTTAAGCAATTTTAAAAAGGCAGGATGTTGTTGACATTATACACTGAGTCTTAACATTTAATATTTATAGTGCTTATTAGTTTGCAAAGTTGTATACTTAGGAATTATTTCAGAGACAATGTTTTCTTTTTCAGGTGAGTAGTTGCCGCGTAATATCATTGGATACATTCTTTATACTGTTTGTGAAATTAATACTAGCATATTAAGTGTATAAATAGATTTAGAAAACAATAAAAAATTGCATGCTATTCTGACT + ADED,I@HJF?JAGG?CH;IIH9EIH?FHEB.HFHDGIHK5>GGHJEKK<>H+I:EGFFH=:CHHDEIK@D>FEB>E@>D@A@D><7EGFHEJ:IHB8B8I5JEF>>HC@KKCBEG9JECD,IHFGGHC'K?EJGGIGHJE?IAIAB4>.JHIH9HK8JBJHDCA9B/?HHI:K:IGEIIJKH=HAFFH=C?JJFCHDF>7BC1:HJJHEHII1FAHC@6A:I@ADHID:D2FEDC@,C5HJ?6A7GIJHCHGJI?HJFGH@FAD=DC8EGGD;@=GGFHKKH6DHK>KIJCJHJK6HKHDHF-CDJFFGF>6DGK0E33GHHGJKC@ED-DG=@GJJCFFKIHDJCA?HJ@AKDE@0AEIJFGC@9BCJGI;@>DHGFGJGHIGEHBD@C>IJBEFECA83.DIKKEJCIJ=A+41ED;GAKEJJAGG*I@>B>KJJ5;K:I;KJK@FD7:C;DE>FJ>F4IHG;KHH;C5AG>H:GF?%C7:DCIGFCE1F?IBI@FF9?EE$GCHI;:?>@8>=@@:,A=DDA9DJEE1FHJDJHH8B:DIFFKECBAA26AEEBFEKGJ=CFBC>CFKDEFBA,:AHDGJDGKDB9IJJKFJIGIJCGK>FJH5FIJEKFKKKKD/HGIBFIKGK=GGKFJJKKDHHJJECF1E9K5DJJGBJ=JKJ>,@FKJ6IEKKB=+AHHJIAHGHHBBCGG9DJGCJ1BBIJ7G>AJJKKDGIKKEJJKKGJJ<>KKH@AJKJ9EKIKJHGDKFIGIFGEJK0IBJDKIK7FGJJKKKFKDJ8E4KKEKKKEEBJKFKHB2DH=DGEB7JKK6CFKJ*HKKIHGFE%K;K;IKKHKJJK8KIK9GJG@DFKIEJDJAEFJ>KJJKJKJKKA6C(==AIE8D,GKI3?AA?J3GGA'IJ@E@&FK+H?BAG0IJ@-JFICB1HIFIKAG>:*F1G$C77FGJIH8D;D?JKBB>@<:IBGD@I8FJ?HH>FE,;=J>BAD5F;DG-;KAF?FJFFHHDHHJ>GJ)G4H?F)DIIE(>IC=JJDFI;:H=3E>BH3HGJJJJ=(BFKH2D@=CCGFCAA.><6>CH;@C?%IFD&J5FF79=.-5*1$2(($75.63*0@DDFE><@3/DA(.AB925?/;@6:FH;A8HHE=B@C?@BFC@C8EF,KAKDGJHGHIH,;KBEGH>@GFEBFG97G8=E3JEFBDA::;AC'C>FGA@GFHEB*C9HDG5GI;GG3CEFE'JKDGIDHHDJ;BI8HIIKEEEFIH(BC:FFHJHEFE@<HEKCHBGFGK=HCEDC/IGBC@IHCHAJ=IG=FFHI36<6;8?<)BCGFG1A:D=GF=FEGCHDHF7@==H=8D7?D@/CEFBHI4A@C?D8G;ED?0?>690@@=;1=:BBC:DCHBB0=<7E?7DCAEJ4FG;%CBB:/BF<=?GI$$%C5=A-9@:>==AE3FFC8HHE7AAAD.C?79?6>?FH>J;D>AJACD=EED*BH=DEGFJ:BDFDC,CFG3=?8DEABG8AF?GCCBICD5:@>HBEIGECIFDCHHG;@9CIECI?/<-6<<'A:>)@EI?>>E9ACJGH8AFFA>BFJ?EGDGJF?E@HIH3EGAEB??BB%E1EFEAC9DBH<>GGC@8 @rCer/332/0_730_CCS AGGGACCTTGCTACTAGAGATCGTGACTTCCTCCGGGAGCCACAGTCATAGAATCCCGGCCAGCACGTCCCTATGCACCAAAGGCAACCAGTGGTGTGATACGACGACCAGGAAAGCGTCAAAGCAGGTGCAGTACCTGAAGGACAGGCAGCTGGCAGCGCCATGGTATGGGCCTGGACCTGGATGACTTCCAGGCTCCTTCTGTGGCCAGGATCTGCGCTTCCCTCTTACAATGCCATCAAGGATGCCTCGCCGCAACTTAGCCCTCTGTTCTTCTGCACACAGCACGGGGCCAAGATGCCCATCCCTCTGGCTCCAGTGCCAGAGCTGATCACTGCCTGCTGAGTCCAGTTGAGCCTCAGTCTCCCTCCTGGAGCCTATGCAGAGGGCCACAACACACAGATTGAGCTCAGCCTGGTGGCAGGGAGTAGGATGGGCTGCGGGGATAGTGAGGCATACAATGTAGACTCAGGATTAGTATACACTGTTGATTAATGGAATATTTACAGATCCCAAGCCTGGCAAGGGAATTCTTAACTCCCTGCCCCCAGTTCTTACAAAGACACCATTTGGCAAGCTCTATCACCAAGTAGCCAAACATCCTACAAACACAGTGACCATACTAATTATACCCTCTGCAAAGCCAGTTGAAATCTTCACTTAGGAACGTAATCGTGTCCCTATCCTACTTCCCCTTCCTAATCCACAGCTGCTCATAAAGTACAAGAGC + S(((##%#&'$#('$&###'($#%'(%((%'$&##%'((()()'(*$$'',(,(+(#$(+-'&&%#**$00+)/-*,'+$&*+0*-/120'+-0$%$%.-*0,)-/0,0.,1'*(,+,,/%,*)+('+*-.)+*/+,,0.*%),10,+*.-'0.2++)-+0/0''/+++*(()/3-54%*.)*$155.*0$0/-5+-120244(3'0'--&/.(./+0.#)/+4/))(,-)&,011653510+0*,-$110++.5)*1,(,),)0/./+//42&11,-(,/45/10141656).('$2..'044&$2220*-42(2580#''*-&2,,,,/21)$,.&707679.%4.77()74:53:*461/(,&4)+*.$(*40.69.-.:792'99&5304:-44++345$2#-/4351')6005*)4,.'34/$+,')*$,313'04%02423/859:.4453&45:-1*$+.3559'52-50652-+-02(65:5:89/38,,'7$4$)-/)3+.0&612:8294+92,8&7217-73,1$8(/,7115%0)/3*&+7/-3,#-8.'260.1&'38(64+9.64156952&//97-1%)8%57/.1$737:&*$0550,,2-2:-/10&34'0/,-(2332498-785&76.%63*461&*7124.3417+6*553:55',-0+:935,55::6+9#2551:(51)+(+54614&185-+(.%33228675,--3 @rCer/333/25_1932_CCS ATGGGGGAGAGCGGCGCCGGCCTCGGAGGCTGAGGAAAGCAGGAGGAGGTGGTGGCGGCGGGAAGATGCTGCTCTTTGGCGTAATTGCAATCGATTAGGATCGTTTCTCAAAATCAAGTTAGAAGTGAGAGTTCAGATAAGTGAGGCCGCCATTGCTGCTTTGACACCTCAGAAGGGGAGAATGGATTATCAGGAGTGAAAAGAAGAGCTGCTAGGAGTCAAAGAAAATATAAAAGTCCAGCACTAGGGCTCCTTCACCCACCAAACGCAAGGACCGCTCAGATGAGAAGTCCAAGGATCGCTCAAAAGATAAAGGGGCACCAAGGAGTCAAGTGAGAAGGATCGCGGCAGGGACAAACCCGAAAGAGGCGCAGTGCTTCCAGTGGTAGCAGCAGTACCAGATCTCGGTCCAGCTCGACTTCCAGCTCAGGCTCCAGCACCAGCACTGGCTCAAGCAGTGGCTCCAGCTCTTCCTCAGCATCCAGCCGCTCAGGAAGCTCCAGCACCTCCCGCAGCTCCAGCTCCAGCAGCTCTTCCGGCTCTCCAAGTCCTTCTCGGCGCAGACACGACAACAGGAGGCGCTCCCGCTCCAAATCCAAACCACCTAAAAGAGATGAAAAGGAGAGGAAAGGCGGAGCCATCTCCTAAGCCACAAAGTGCATATTGGGAGACTCACAGGAATGTGACAAGGATCACATCATGGAGATATTTTCCACCTATGGGAAAATTAAATGATTGACATGCCCGTGGAAAGGATGCATCCCCATCTGTCCAAGGCTATGCATACGTAGAGTTTGAGAATCCAGATGAAGCTGAGAAGGCGCTGAAGCACATGGATGGAGGACAAATCGATGGCCAGGAGATCACTGCCACTGCCGTGCTGGCCCCTGGCCTAGGCCACCACCCAGGAGATTTAGCCCTCCAGGAGAATGTTGCCACCACCGCCCATGTGGCGCAGGTCTCCGCCACGGATGAGGAGAAGGTCCCGCTCTCCGAGGCGCAGGTCCCCTGTGCGCCGGAGATCACGCTCCCCGGGACGCCGCCGCCACAGGAGCGCTCCAGCTCCAACTCCTCCCGATAAACAGGCCACTGAAGCTCTCGCCCCTGTAACTTATACCCCACCCAGCTCAGTTTGTCACTTTCTAGCCAAGGAAGATCAGTAGGAAAGCAAACCCTTCACTCGGGCAGAATTGCAGGCAGCAGTCAGCACCCCTCTGCCGGCCGGGCTCTGGCTGCAGAAGTGCTGTTGGTTTGGGTGTTGTGTGCCTGTCAAGATTCCCTCGGTTTTGTGGCTAGGAAGCTCGCCCGCTTCCAGTTCTAAGAGTCAGTTCAGTGGCAGGGCCACCAGGGACAGGTGAGGCTCTGGGGATGGTGTGACCCTGCCTGCCTGGGAGCACACTTTTCCCTTCCCTAGTTACCTGAGATGGTTGCCAGACTGTGCCCTTGCTGTTGCTGGGCGGTGTCCTTTTGGAAAGGGAGCCGTCCCGAGCTTTAGTGCAGCTGCCAACCCTGTTAGCCTCGGCCTCTTGAGGCCTCTTCCAACTTCAAGGGTCACACCCCCAAAGATCCTCTCACCTATGGTAATTGCTGTGCATGGTTCTGTCTGTCCGTGCACCCATGCACACACCCCACCCACCACCCTACTCTGAAATTGGCGAGTGAGAGCCAGCTGTGCGGGATCATCATGCAGCCATGGTTGTGCCTGCCCTTCGTGGTGGTCTTTCAGGTTATCTTGGCAACATGTACATTGCTTTTTTTTTTTTTTTTTGCTTTTTTGCTTTATTGTACAGTCAGTACTATAAAATTTCTCTTGAGTTTTATACCTTTGTAGCATTTTAGATGACATTGTGTTTGTACTTTGTTGTGTAGAGTGGAAGAATTGTGTTGAATAAACCCAAGATGGAATG + =?%@?@981,9B:C5:&:=9A14>7&=57C5(<:-@;&<<0C>:?>;3?=AB/D?9;?:5$9.2C@.C/;BB?=:#C6:F@2A=575*CB;<=8?(<;6C@7B@7<8D;B?7#3>.39@;5=4=??:9=&:;<<&=;:3<$;EE94>9=;A*CB<&134,%3+9=>;<>E8ABA>:C9AD9<1C4G159ECA:A+FBB6FA+FC+EE/)9?@)@6D+0;A,683:B=?GA51A949%AD-BF@)B<=@;BECE?<@EE2>-?:<7/>>4B=72649993C9@?;;7A*80<@;A@=CE1/+ACGB?>A@>:><@DB?C@?3C-7?;>.)E?BE@A2?5@@?A92>E@CB;A@E5E9=5EF8BDG@>)?DA>EA7C,<=BB3A8A?:8AA(?=>84>@48?545/8@=>0?28A?;5.859,>6;3C'><>:)<=A@4A)896,<2>B;<=7>:-79:1:?A2:4<:49>>B?98(784A@7>4;+?86155AA@C?0=8%/=;?@9@9#C:?>B@F=5=@DACDEC946,@CG0JB:JIGD9IH8GGG?H%AD>?>CE=G=CGB&D>?BAG%FF8DDB7E@E#DDAB?FBFIA>$B3CEAE?D347BHBBCFEI0JFF;D.IACIADC=B5GGIIIFFBHFFHIEGG8F@@DDAD>G;E>G;DIBD&DEGHCGE5JIJI@BDHF?E?FED.E:C7B?HHFEGFCF$A:AA7I6IDB.=,E72HC(BB<3?8D<7EHHD/DF6*F>;93<4EB@AH=+D8(?;:DC)FC,>+>&E?;=G%;@H?3FF6J@EDIEHADHH>5>GEBDEEIHG=JIEIF7IA*AF@:D?2DG;C3HADCGG<9GBC,?GD(B75B>8F96CA.CAD79E?>';@A@E8F@DDG0F=)7IB+@BB?99DFBA@H:E78AGBFAB)EF@<@:EI9GFH10D+IHDA>''(D4>A'?G;@BAD'HBJ5D6IA;>@F:JH84>HBJ>E(@5C+@148AGCH?@F7HD=HHCG?*A=BGD&>:CH;GC8120HII9@=C;/A/A:I?6@(79>5G4)CAAC@>F=E.@@A5?:AB:DBCGB:HG8H=>;8=>4??FF>F;D?FA?4:8H=7E6GGE-ICG<-@0HHI9A+BD0CD?57DF9C:H:G*AG:G&*;7G/8,:2H4G:'BD8-8251)AHH0D>5,9=F8F:AC1EG49=E?->2@HF:F@FDAC6E/B@??=E=@CBJH@BC@*5EADHA<>>><;AGE1'@B>:=B/2CHEDDE?9FI@A)9F@C>>?<@=DFC??,8>BB@F@F7=A/@BC0FHC&FHGECBDBBADIHHE@@C%EGFCCEB+BAA?FF8?FD===A=<8<573.>CC:>4CA:/DD82&HGB,A8-B@I@GI9BHG:FCIEGCF>AAH;B@F6;EC@CJB(JJ;8IG@DHBGGDA=E6AF@@'AH9CBKJ':92GG(EJ;FF5$;I6E8I @rCer/335/1958_54_CCS GGTCCCGGTCGCTGATGGGGCCGGTGGCCGAGCCGCCTGTCGGGCTGGAGCTGGCCTTCTCGCAGCGCGACCACCGACGCGGAGGCACCTCTCGTCCCGAAATCGACAGAGGGCAAAGTGTTGAGACAGTTGGTGTGTTTGAGGTGCAAAACAGAATGGAAAATATGAGACGGGCAGCTTTTCCTTCATAGCATTTTGGCTACCGAGTGTTGTCCTGTTTCCTGGCAGGCAGACTGTATACGGGATGTGGCTTCTGCAGCTCCAGAAAAAGCAGAGAACCCTGCTGGCCATGGCTCCAAGAGGTGAAAGGCAAACTCACACTTCTATCAGTGCTGATTGATGCCGTGACTGCCACATATATCTCAGAGATCTCAGACAGAAGCTGTGACCTTTTGGCTAACCATGATGACAGCCGGCCCTCTATGCCATCCCAGGCTTGGACTATGTCAGCATGAAGACATCCTCCCTACACCTCACTGATCAGGTTCCCATCCAACATGAACTCTTTGAAAGATTTCTTCTGTATGACCAGACAAAAGCACCTCCTTTTGTGGCTCGGGAGACACTAAGGCTGGCAAGAGAAGAATCATCCCTGGCTGGAGCTCTCTGATGTTCATCGGGAAACAACTGAGAACATACGTGTCACTGTCATCCCTTCTACATGGGCATGAGGGAAGCCCAGAATTCCACGTGTACTGGTGGCGCTACTGTATCCGTTTGAGAACCTTGACAGTGACGTGGTACAGCTCCGGAGCGGCACTGGAGGATATTCAGTCTCTCCGGCACTTGGAGACAGTGCGAGCGGGGGTAGTGGCAGGGAACCTGTGTTATCCAAGGAGCAGCCGCGTTCAGTATACAGCCAGTCTCGCTGCAGGCTTCCAGTGGGCACATGTGGGTACATTCCGCTTTGAAGACTGATGGCTCCCACTTTGATGTTCGGATCCCTCTTCTCCTGGAAAGCAATAAAGATGAGAAGACACCACCCTCAGGCCTTCACTGGTAAGGCAGCTGAGCCCAAGTGCTTCCTTGGTCACCAGGAAGAACAACTGTCATCCCACAATTGCTGCAGAACTCTTCTCTCCCCATCATGGGCCACAGTGGTCTCTTAATTTGATTGTGGGTTCTTTTTGTGGTGAGGTGGTATAACTTTTCTTCAGAAGACCCATGTGGGACACCTCCAAGGCTGGCCTCCTCATAAGCCCTGCCTATACCATGTTCCAGTAAACCTCTCCACCTAGGAACTGTTTCAGCTGCACAGGCCTGGAGGAGTTTCCTGGCCTGTCACGTGAGGTTTGATCAGTAAACCAGTGCACGCTTGGCCACCCTTGCCATTTCTGCTCCCAGAGTCTCAGACTTCCCTTCTGACCCAGTGTTGTGCCTTGATTGCTTTCTCTGCTGCCCTTCCAGGGAGCTGCCCCCGGTAGGCATGTGCCTGTTTCCCTCTCAGCCTGGAGGCTGGCTGGACATCTCCTACGGTCAATGTGCCTCTCAGCTAGTTGGCAGGGTTGCTGGACTGGACTCTTGTTCACTTACCTTTTGCCAAATGCAGAGAGGGAGACCAGTGTCAGAGTCAGAGTGGCCTGGCTCTTAGCACTGACCAACCATTGCCATTTCTGGCCTCGCTAGCCCAGAAGGAGGGAGCAAGCCAGTCGGGTTCCTGGAGCAATGGTCGCCAGCCCTGAGCATGACTCTGCCAAGCATCCAGACCACAAATGCAGGAATTTGGCCGAGGAGCAGCTTTAGGTATGGATGACGACTAAGCCAAGCTACTTCCTGAGCTTCTCTCAGATTTCCAAGAGCCAGAGATGAATTGTGCTGCAATTGCCCAATTCTTAGGATTTCTTCTCCTCTGCACTGCAGTGATTGGTTAGAGGTCATTTTCTTGAATTAATATTAATACAGTT + -'*(&$-(,'$)--#)+-)'-'*'()'*%+(%'*)$*-+"&#$%,,0'*.--+$+,21100/'&1/$%(,,(+")%,$.(5,150-)'$0+-(0/5503-+''-0+$).015*356-21/2/&-.331.2$-//55)56-3+.,5*%.,.%1034/33%343%0+.042-%$2&5532435)3.20640,0*,133$++5220)3-)#+0'14/*033,%,)4620)5,)//.0//-+$+$&4+/0.54015-452/44230+))/121&-0+/,.1--.&+''03(2,400%005.*'(((*0/3,)20.,+#*+$$)+,4$,12*)-$+(&*366340105&4*,.%..1&(+-251/*%.*($)-1+(/%1*-)*+4+%1%/)045/,$"#1()24'1*5-/22134030).(+-'---+0/83,375,25.-5*9)-475973493'29584152516.302&70*),25#,.6:5/55419156%94738428)16-33,54%37917422&&91,+50-.577'5401798*3-1-)4:4055&97;345155,(416/3*2*5(+692543,.18+.5.,)5//.%62'479-.4775507:82432637575*/1&26.$22-/2)',%.-+/4/002.4011455-70*2511644&.42'212&3(-43(((5+4,3)*&,,)./&,0,34/0520-359:7544571'$2775:6771.2)&04592*.'-45/6'3-&7'+-8:6*5.49127/96567558%+2-2:20-/&01&2-553/1269(-%&)$%%+$'2513,%160*7+:536844159827*3-59908:.05960+',/10#/17/4%)2:963224:8:4+4&9342254(+1--40,84+,'23404(11./')1&,/(002..-/+05(2-/1%+0(353131366-(+$21.33&%2,34&,12,6::.55361.51-12/3&/32&4447*9'7059%7:65:0++'742-43'89'.-33-,343093:67;:9,<5%5)5:+5<681=699858'95;/<9;49768=:69<,>36:9:020$2.-/686+;5;87081'),4(7,>;72)847+:-4.(1%(7;<8&51<32/12)3=>A>5;065B->?6=3B7BBB:@)@?4BABBC>A@A0?A?-7<=42)<,/9-7)9>4;=,<3@4?C:98(>:@>?<:9;;?'96:5B=(A?B=<>&=A;=@:;1<=,C>@@5A3<==B;<>7>=;&A@,;=@<>AA@?8B8B>>A;5==AB3>*>12C@:?3:<:9AA=???==>C3>7>98:?:<@@7C<=?,C989A;7:03863*&/76A*54<9<;6<<:.0:8171:5<=,?99(5@;A8A6:37,<7<8>585:=>49*788:/;3938:-=><>0>A958&-;'6747$3/&4:;.8;/;;1+--/-10..*)035610/,25410*21411-126..)1/+/1*601051,2111)5--%065635455-5260,25054,,$*5*-%&($++,%)&%-2*.20(,301.#)$+'/10*.+2-*,$#*./**$/-(+$').+1.-/0'213.650.511*1-1201(50))/223'2(42)0(1-//0*,(,.)(0/'-522(04522,5-(*456.)5,4-5202+5/)''+)/'0'.+-/(-31/0(.%1+(,/-&*010'/(*&2)%+,11.12&)(///$%$&&+0,02-(-.',2/-',((&'+)111,.+.00,0)-%20,,+1,,&)*-/'+0(-.*-(+*11/,*$%)).--+ @rCer/336/25_1489_CCS ATGGGTCAGCGAGGACACGCTCCACGAGAGCAGCCCTTCCACTCTCCGCCGAGGAGAGGGGCTCACCCTCCTCGGGAACCAGCTACCCGCGTGGCTCCCGTCAGGACCAGCCCGCGTGGGGTCCTCCCTGCCTGCTTGAAGGGTCTGTCCAGCCCCGGGAAGCCACCTTGGCCCCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCAATCAGCTTCCCCCATCCCTCCGAAGGACACCCGGCAGGCATCCCCCGGGAGGCGGGGGCAGAAATCAGAAGGGGTGTCTGGGACCTGGATGACCAACAGGGACAGGGGCATGGTCGTCATCTCAAAGGCCCACACCCCCAGAGGCCACACTGAGCCTCCCAGGGAGCCCTCGAGTCCCCCTGCCCAGAGACGTGGAGAGCCTGTGGGGGTGACTCGGAGCAGCAGGTGTGTCCCGGGCGGGCAGCACCACGTCCAGGGCAGCCTCCTCCGCTGAGCGAGTCACATGATACCAGTGCCCGGCCAACACTCCCTTGCAGGAGAAATTTGCAAACCTCTGTGGATACCACATTTCCATTTTTGTGTTGTCTCCAAGGCCCCTTTGGAGATCTACTTTGTTGGTTGTGTTTTTTGGTTCCTTTCAGAGAACTGTAAACCGAGGCTGAAGTGCCCCACTGACTGTGCGAGGGGCAGGGGCAGGAGGACCGCAAGACCTATTTATAATATTTAGCAAACTCGGCCTCCCTCAGATCCCCCGCGAGGGAGGCCGCTGGACCCACCCCGCTGTCCCCCACGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACTTCCCCTCCTGGGTCACCTCTGATGGCCGCCGTCCACTGAGAATGTGGACAGTGTCCAAATTCCTGTACTGTAATGACTAAAAGGCGTTTTCTCTGAGACTGACAAGGCAGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCAACATGTCCCCCTTCCCCCGAAACCTGGCTCAGTGCATACTCCCGTTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCCTCAGTCCCACCCCAGGATAGGCGCCCACCACCTCCTCCTCGTCTCCGGTGGTCAATCGCTCCTCCTGTCCCCACCCCAGTCCCATTTTTATGGCTGAACTGATATCTGAAACAAAACGAAACTGCAAAACCTCGTGTGTCTTAACTCCCCCCGGGATTCCACTGCATTCCTCTGCCCTGTGGTCTGGTGCGTGACAATCCAAAGCGCTGCGCCTCGTGGCCGAGACGAGGGTGCTGTGTCCCTGAAACCCAGAGCCGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACAACACTGGTTTGCAGCCCAGGTTCCCCGCCCACCCATCCCCACCACACCCCGTCTTTTTAGAGGTCTCTCTAATAAATCGGGTAATAAGCAT + 4:4?><=986>=5A;0>;A5<<<;>A8@>9@7?>)@@???B<8<7>/5070?>AA6?B;?4BA9<@>5>>CB7>61;;7?@?=A>AB7B==:@<@=@?>;<:8AB@29:5?@3><:A;:89&?@?<:8>>:?9>6A>??;;46A@81<>373>:<<@1:@>7377:8@7?====<4=1>=179837=629:9<:<579':;17;7/:549%768(&;354576:8=:9<=:=?;7><$9+6474;:=<7?<:743299>=>5?8=>9/>97>94;7;4829:87=30<9<;92?::=9?>5+<2<=>:<5:7;9?862=;;<=,>4%49=8>:484=:5=::81-=<5=180??335:,7:92<:;==9>9;,2<9;==<6::>:8422776=1:68.&5*899=8448==;>86;><<=>;?<7==>=77?6/=;78>5;:<95=95704758;;=5<3<&34/27?7<;5;=*697;56:49689><.<:4<5;?4?>;9<75;59::?;=7:=<:?7,=;:=:<==?;>>=:=.:9<4??;:?=7?0<9>=:7:1977)27;188:8%5<9667;.;6=398;2587(796=:3>>+946.97054:859-<:;:<=<9>5619%933?=;995:=>>:977)85<;;6>>:=?:>9<3.7??=?8<>6+;9=8>6=<;;8=;8;><.;;<9;><<568>?;=>:2<5074;>==0/:>=66=37259;6+91874)5:>7/84=>>;=776=9-7=>=831459:6=4.3<;6>6179;789'5/=149<53:.:=9;*;5;;3<5695;=>486,9:;868<+:;5938;<;>:=85;>8:19:9:0>:98648<63178<68=>=::59=;><6;;3?>:?9;45788:*863985:=8&;896+8%99757789598/:36:88395).-72.7886987654*855639'454/88-*5(/0*/239*3,424(4065:642#55.166:989-/1+-3+&87065639824258.6::8/+63;23:8,,.6:788943.8,01/3995/89:521/:82&23,..24551*475392/#-4780987369;792;;0173%35559584981666194910'6650()49228564.$/55488307./,682498843532.02452458;67929759159::5.339:717556247894576(20(%,/508;9869;5:85013(56/*0/*222969:2684;28::/659630-33392:/728575;86641,6;8:675699558,5189:6*5:9/262/03::78;7./.869645+35888667636::5445;8/8766.8993530.3,41 @rCer/337/2077_59_CCS ATGGGGCGTCGCCCCTCACGCTGCGGTTGTCGCTCGTGTCCCGCCGGCTCGCTCCGTGTCGCCCTGCACTGCTGCGGCCGGCGCGGCACCATGGCTGTGTTTGTCGTGCTCCTGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAGATCACCGGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATACCAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACCTGTTTCATCGTCCTCGGGCTACTGTCATGGTGATGGTGAAGGGAGTGGACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCATACCCTTTGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGGCTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTACGCCAGCTCCGTAATCGCCTATTTCAAGAAAACTCTGTTCTAAGTTCACTCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCCGAACTGCAAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTGTATTCACTGGAGCTGGCAGGTTTGGATGAAATTGGGAAGCGTTACGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTTTGCAAAAGTTTGCAGATGACATGTACAATCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTTGTTAGGAAGACAAGGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCTGTGGTTTTCAACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCATCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAACGTTCCCTGTGCCAGAATTAGAAAAGAGCGTTGGAAATTGGCTGTTTTGTTAAAATATGTCTTTTGGTGTGCTTTAAAGTAGATAGTATACTTTACACTTACAAAAAAAATCAAATTTTGTTCTCTATTTTGTGTGTGCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGATGTGAGTCCCACTGTGGTATAGATTCCATAATATGCTTGAATACTATGATATAGCTATTTAATAACATGATTTCATTATGTTTAATGAATTTGGAAATATGTACTGAAAGAAATGTAAAACATTTAAAATAGCTCATGTTATTATGGAAAAAAGTGCACTGAATTTATTAGATAAACTTATGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTATACTATGAATGATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACGGGAAAAGGTTTTTAACTTAGAGTGGCCCTAAAATATGGATGTGCTTATATAATCACTTAGTTTTGGAACTGTATCTGAGTGACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGACCTACATGGTCTAGTATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATACAGATGCTTTTCATTATACACACAAAAATCCCCAAGGGGCATTCTGAGGCATGAATATAAAACATTTTTATTTCAGCAACTTTTCCCCTATGTAAGTTACTGTGGTTTGTGGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAAATAAAGTTAATAATGATTC + KKKKK&KKKKKKKK/JJKKKKKHKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKK@KKKKKKKKIJKKIKJKHKKKKHKKKBKKKKKKKKKKKHKKKKGKKKKKJKKKKKJKKKKKKKHJKKKKKEKKKKKKKKJKKKJKKCKKJKKKJKKKKKKKKKKHKKKHHIKKKKGKDKKKEJKKKKCKKKHK8HKJKKBKB,KIIHKKKKJKKDKKKKKKKDKKKKKKKKKKKJFKKJJKKKKKKKKKKKKKKKKKKKKK=JKJKHKJKKJKJKKKKKKKKKIJKJK;KKKKJKKKKKIKEKKKK/JKCKKKKKKKCCJEIJKEJJKDKK5JKKKIJKKKKKKKKKJIJIJKKK(KK/KKKKKKKKKK@KKHJKKHKK?KJJKKJGKKKKKJKJKKKIJKKKKKEJKJKKJKJKKKKGK=KEKKKKKJK8KJJKJ=5I;KIKIJJK;JKKIKCGHKDKKHKKKKHKK8KDKK@JIJKJKIDKKKKEKFKKKKKKKIJKK?KCIHJJKKKKJKKKKKHJKKKFKKKKKKKHJKKKJKKKKKIKIKFKKJJKKFJKKJJKKKJFKJKKGGFK@?KK4KJIKJKKKKHJJKKJKKJKKKHKKKJKKKJHKHJKBJKHIKHKKKBKBIKJKKIKHIEIKEKJKJKKKKEKEJJJ=KKKKJKGJKKKJJKK@KFJJKKKKIKKKKKKIKKGK?K2KKCKKKKIKK7DJHBH?FIJK+IKK9KFJ9K>JGJKIJFBKG@IJJGKHGFGKKFFAKFDJKIICIJJKKJ*JBI9GGGIIHKIA/6;5.6.199/85/6545;67096>;80385434387*78./2/..()30+2;7;=>4757-$9;2=?9=9;=26=88,603:.67(6=6);9.:/(68657-5075%643214)9019635320:7;12=<=..+:583::/43762;8=;63:3:>.>=6798:67-89098;793(7575:79:8>:42/-293827=;?598:<:<476(9>9170/56>:19;5745/378:665;;6:.7<.<657=:>6;<9702::/6:?::-7<17152937=0=7,2,4=14922,55390*816062-90471+64*7132782/22154547(0948:8325210-73),65/973-5531644593;981878486/)2.40)10855955666.+2474.-,/28:183367+2(/$39529664),62*,1245/63745;58+0.)3119916.6737+4)9:2888.1093+219+/501)45::/:99;985:6426764893142/$847829:926675144-796986)9961)/664(74629:272)67666(54453'783+1'/93284++85,985109;/729758:1+355516.42(.461-13.2076.-63342&670410194637)446632'22(7326-5986+747150*25--528&646+3134-8.86-;8775/1345:07746,+0.6//11/005/'$34/,(*042.3349701,05258277%539/8;752-27-5492(*(117/32+./5:15486:554$.75675814),-+0+-:-.502-79442489425+/217389749279659/52/11:70131395:7;15782(357860)3/43248*58-*&3896756674748)9:59.02,3150%487574765+33/458253365294+41-316566343/974(1,458335*7,186:2(1-+4422%20297:6117,24;7568,8817,44;55997:893+475+354$4:79,:6;592*6/1974/85480558728.55-0/136036*,626:293613;8552-508228:574866422/03%5,'&13/2.42+.+2.0,'&/2--2+32054&.7+34,37.,(/35519/2(44,3:6583-030%,94-,4,,0*769/(3./(-+5452-674763.,-714+529679.4864733905/4/,3611*94657,238/172:27882*582867%50:6937.8*9225,89385444/4.*-/-155-3876-/0243386485382143-76-5638788040+48*127:-:2796151184343'356,/85111(62-7.596+277264934479+:5647835/+/520*12*2-10+01/+055624-,.6;9:5419-641/3.11.(64866611*-65586:2..58,30065.7:8:4*.95*%2423403352281495456843;-5953'/965;14433/43604384/5/19524588;8(2/2.1.21--25411.07'75.5-24023/2326.9596006,015623,0+/1.01*.3*2*/34.1,50.1*.0-4-1/&05*/1,(.&-54465)(5(53143--2/36,.4220545/1)563543066332315,1,1245.4.101.)/54*5540400542/50-14,/4)%3.5330/3$'2,432165616601-550233'.-24*2.)2/234.443/-0 @rCer/341/25_2137_CCS ATGGGCAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGCGCTTCTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGAGAGGACTGTCCCCTGAGCAGATTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTAATCCCATTTGCCCCCATTACCTGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCTGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAACAGAAAACAGTTTCAAACTGTCCTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCTCCACGTTCATCCCTCCACCTTGGACTTTCTTTTCGCCGTGATGGTGACCCTTGCGCTTTTTGCTGGGCACTGCGATGGAGGCACACAGTGCAGAGACAGGGACTGGGTGGCAGAGAGGACTGTTGACATCCAGCTTCCTTTGTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGGGGAGGAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCACAGGGTTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCCTGTTGCCCTGCATGGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAACCAGAGCCACAGCCGGAGAGTCCAGGAAGACTTACGCCTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCTGAGAGATAACCAGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACACATCCTTCCTACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTAATATCATGTCTATTATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAATTGAAATAAACAATAAACTTTTAATG + 32'1318465711183;36;/5:80308/1,73'6)4:-/,.5/85425/+123)#.,#,214&,'624/1&2*#3745+7688)9.13:,.-1146--7&668135(13769;9/2;.4:*,**26354.+.23+627/2::%.+5429606.6878(4136268-5/51(685'(&8/84*3#&+*+,+310242,641-.0.'98'565-46:6&2**96+3,78+01,,1*1.1+.-50%10.2657.55060-65962(,,-1-5440.%54527:9:4;69(12%33331,*$853(45+3-03.16+02515::8;6.688+9815945/6576685-+98+8:95133373'63356*83+3004430/0$6313774227((98861'87747,898;/74,-1,72251412(56%20.,/487+0.01.2,/8.7757$),68011:4:87:47)868&23/94;:83.35329,756-5762550)28393407'43/5/36:,3:94(*$.1054.3)(*$(/3(0-22,//2/+-20,0.0--/1+(//.-1/**0112-0./&/+11101&-%/2+.)/,*-*--())+'&+%/%(..4%//-(0*/0&.2/2555%20...04./1(#-1+&$/.*0&/0)(3*'%%/1.(,)3(33101632-01/1./.0/('$-.4*)(1,//*.'0/'0,23,'2164+44661036(0(.-)/26&1//-04*0%/'/1$330-.&033.*2*541*425662*%(55223053+)-+1//()$+4+016-)56)(-15264+3444+4/35(+)31.6632-415)342.%02/425211+550/&&-412.+3461..+4/*153(3(,/2.+,44-/56652+22523.03./($#.,40*-.,466441.+-20053665-1+11/3031../-'5/*1+/14,'$+-,%(132/2405.-.-44113(0,)-0/**$+*0323'(,.'.35443442-..54)2/5.&'(*)&3.-30%.+12034/061/%444./44.10)-2-06,''055(1(2-1,+&264664+15++(,./53..4(025151(22+4/*/*.0/22/3.4611)224,5)).+-126*0,/..0365-5/-22/21-.4+313/-33&/23/(/+3.4053*2*040-.30+225.15321++1/,.2100.()-.501/$450/,#11.32$(&%/+-/5-21'/.,5/%-226*'-+/'/)-*4,&-,256-%4-0++.'&*%111626)34;1199:57/2'7658307258:5'44974*$35273(74565/1)2,+2#757943219+/12++32-0404)3841,69.,$4191573$2(.'6188654081193,5.466/299897%5333353,4+2/240-,4.101951:4;6774/9466:69/:883-4.08(5&74613,'4997892-/)1-)8'74/3354,-35'04%13157983577:3;16/63.+1*,#%)+$840/,%*$3+9,9586889203,*10.2),..3+10&.9)4607207::4932.7-1.23;5739.'-2-708&034%47:44845/46+1*/)0,*),+)../..-1-1,-&/031,4958+85914/2645+-&-900/$$469:0,%5$)1.,-/621-2441&)%2%,(524559-87(86.-68602-81.+287&465.2)0,00)&.51/.03/)#$%-/2./*'3%/06.5&30).&(55475*5292271+/01-'01-./010*.%+,,14*3:040-54.430/*&'/.%..1/,8+521+2/)3+0528973306/75751)(+43)022/,351281'.12210353--2(01&-1*..*%.056919562,,*//5617.-'2-6292(876).+5.8)0)*'2/'5555-1.&88561*4546.562,389656677:6:81*243/1784(/39786'-0,-'+59752645845.55*41/)//145:94-833*11-2,0654277.4+::9:94854(-1&.(891%8&/819:82567(22.679*762++4. @rCer/344/25_1708_CCS ATGGGGGCAGACTCTTCCCTGAAGCTGCCGGCTGAGGCCGGAGCTGCCGCCTCCATGAGAGGCTTCCTCCTACACCCAGGGCCAGAGGACCCTTTGCCACCAGAGTGAGATCCTAGAGACCATCATCCTGGTAAATCCCAGTGCAGACAGCATCAGCTCTGAGGTTCACCGTCTTCTTAGCAGCTCATCAGCTCATAAACTACTAATCTTGAGTGGGCAAAGTTTGGAGCCCGGGGGAGACCTCGTCCTACAGAGTGGCACCTACTCGTATGAAAACTTTGCCCAGGTCCTTCACAACCCCGAGATCTCCCAATTGCTCAGCAATAGAGACCCTGGGATCCAGGCCTTCCTCACCGTGTCGTGCTTAGGGGAAGGTGATTGGAGCCACCTGGGATTATCCAGTTCCCAAGAGACCCTGCACCTCCGGCTAAACCCTGAGCCCACGCTGCCCACCATGGATGGCGTGGCTGAGTTCTCCGAGTATGTCTCTGAGACTGTGGACGTGCCATCCCCATTTGACCTGCTAGAGCCCCCACCTCAGGGGGCTTTCTCAAGCTCTCCAAGCCTTGTTGCTACATCTTCCCAGGTGGTCGTGGGGACTCTGCCCTCTTTGCTGTCAATGGTTTCAACATCCTGGTGGATGGTGGCTCTGATCGCAAGTCCTGCTTTTGGAAGCTGGTGCGGCATCTGGACCGCATTGACTCGGTGCTACTCACACACATTGGGGCAGACAACCTGCCAGGCATCAATGGACTACTGCAGCGCAAAGTGGCAGAGCTAGAGGAGGAGCAGTCCAGGGCTCTAGCAGCTACAGCGACTGGGTGAAGAACCTTATCTCCCCTGAGCTTGGAGTTGTCTTTTTCAACGTGCCTGAAAAGCTGCGGCTTCCTGATGCCTCCGGAAAGCCAAGCGCAGCATTGAGGAGGCCTGCCTCACTCTGCAGCACTTAAACCGCCTGGGCATCCAGGCTGAGCCTCTGTATCGTGTGGTCAGCAACACCATTGAGCCACTGACCCTCTTCCACAAAATGGGTGTGGGCCGGCTGGATATGTATGTCCTCAACCCTGTCAAGGACAGCAAGGAGATGCAGTTCCTCATGCAAAAGTGGGCAGGAAATAGTAAAGCCAGACAGGCATCGTGCTGGCCAATGGGAAGGAGGCTGAGATCTCCGTGCCCTACCTTACCTCTATCACTGCTCTGGTGGTCTGGCTACCAGCCAACCCCACTGAGAAGATTGTGCGTGTGCTTTTTCCAGGAAATGCTCCCCAAAACAGATCTTGGAGGGCCTGGAAAAGCTTCGGCATCTGGACTTCCTGCGTTACCCTGTGGCCACACAGAAGGACCTGGCTTCTGGGGCTGTGCCTACCAACCTCAAGCCCAGCAAAATCAAACAGCGGGCTGATAGCAAGGAGAGCCTCAAAGCCACTACCAAGACAGCCGTGAGCAAGTGGCCAAACGGGAGGAGGTGGTGGAAGAGGGAGCCAAGGAGGCCCGCTCAGAGCTGGCCAAGGAGTTAGCCAAAACAGAGAAGAAGGCAAAAGAGTCATCTGAGAAGCCCCCAGAGAAGCCTGCCAAGCCTGAGAGGGTGAGGACAGAGTCAAGTGAGGCACTGAAGGCAGAGAAGCGAAAGCTGATCAAAGACAAGGTAGGGAAAAAGCACCTTAAAGAAAAGATATCAAAGCT + 72)::9<:*;7915.31<;179=<:<37>:;985;4:<;=;49=>461:48=3;:52<89.21289;;55-66.(<=9;8=7?6=82;629846:;:=<6=976:<:058059247>5.08.602637:671-::5&332=08970-3:<:8.142:;>36:285>69=<>730;94;084944989>9884:9:3135,36897>88.<765827793==>.?>=?9;170+53.53534=1049=?75396571,;9:8755762:>802-7=6318<80:<820:586565(,5,;;=<8>?78107:6;3<::812596?;=240<3;853=69257,1707*;8887961/14+.35*/(--)23&,9:<7;46?17345=>9?:7<.<9;<:0=24:=7%104<+9<8,3/43;=6>=2:=9>>777-9;7467:)499220//'.6+:5:3==<29:=8)873135008;<>;44;(:59;8/591735:;629;837948655345'6699:375:6(869545?:9:6/9049;2<=3;59?8?748<49875,509):9;:<<072139/:=>;;<7:>1=99738=9>=8-97799?29:8.:9.8;=:67<=?8:<:/3;8=;6;2;=>>2;62&9501&56527+878<939;<*868<>3594/:;7<;:2,00,6<:>;6.1778241::;<;.;=<&5771361:39*67-:7;:=3=72;.12.+47252664)35/50;80<>><10376<98=:<:,60*;:-<=:<;:<8;3<778=:<<756:4=;9>3?;<<<=9?;=7:/<8:9667<>?:?2:9?877)9=78;5:67<648;6*<99870:89?=9=;:4::74086%<6:,<<=;;+1,3:049=88=::7==15-<;:*<=;<:329;9:;>:;6;-9>9==15;1;>=8879/0:73<925==7;36257379<4:;9744:9;30.+0><8:/:;625=/><-12=4;7=89=<8798580*9919,8441:51(5571461,548.:0866591,33:556:72754/6:64.3529&3253188)55648-548:46&52057979;81,$0492%1222:5/31247-6-82*:736754:;9::5=21<;=;6538;?82+=2788=6986=:=9>=><<74833:325/79969:=9185<*9=8102<1<3=435;;9828622=<-====169186?;8?>81=>0-7:68'90'35>;;;'8:$386?21<:7-1;8.>9?>>4:*46:9<2:;.95.271>:=78>;>>3:3.51:80930>0;9;8;>99<<*99;):5=324*+90(=;84:9:?>562>:9953(71267969;/)7,636881>>>2?>::?==900=5=96259>?;=89;7.85*/6)8+;>=7>:9;97+68/9,04-:4/%00097<+5/80)54??:,6<0366710;0=;?:?>>67:53:'3734066601:8;99:):7==<74;789:8==(88287;=4;<523-/2:6/<*==2><8;66>;?<:16;:=>;<=>>8;;:595;76>9=+44:82**77<5:;=87253648=<>99=,<9=8;>4<9>36<<8<49+771&039:===;8.=;36; @rCer/346/1534_59_CCS ATGGGAGACGGACGGTGGCCAGGGATCAGGCAGCGACTCAGGCGACCTGAGTGTGCCCCCAGCCCGCCATGGCCCGGCTGCTGCAGGCGTCCTGCCTGCTCTCCCTGCTCCTGGCCGGCTTCCTCCCGCAGAGCCGGGGACAAGATAAGTCGAAGATGGACTGCCATGGTGGCGTGAGCGGCACCATTTACGAGTACGGAGCCCTCACCATTGATGGGGAGGAGTACATCCCCTTCAAGCAGTACATTGGCAAATACGTCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCAATACATTGAACTGAATGCACTACAAGAAGAGCTTGCACCATTTGGTCTGGTCCTTCTCGGCTTTCCCTGCAACCAATTTGGAAAACAGGAACCAGGCGAGAACTCAGAGATCCTTCCCAGCCTCAAGTATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTTCCAGCTCTTTGAGAAAGGGGATGTGAATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCGGAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTCCACGACATCCGCTGGAACTTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCTGTCATGCGCTGGCACCACCGGACCACGATCAGCAACGTCAAGATGGACATCCTGTCCTACATGAGGCGGCAGGCAGCCCTGGGGGTCAAGAGGAAGTAACTGAAGGCTGTCTCATCCCATGTCCACCATGTAGGGGAGGGACTTTGTTCAGGAAGGAATCCGTGTCTCCAACCACACTATCTACCCACCACAGACCCCTTTCCTATCACTCAAGGCCCCAGCCTGGCACAAATGGATGCATACAGTTCTGTGTCTGTACTGCCAGGCATGTGAGTGTGGGTGCATGTGGGTGTTTACACACAGGCCTACAGGTGTGCGTGACTGTGTGTGTGTATGGGTGTACAGCCACGTGTCTACCTATGTGTCTTTCTGGGAATGTGTGCCATCTGTGTGCCTGCAGCTGTGTATGCTGGAGAATAACCACCTTTCTCTCCAGTTCTCCATTCCAATGATGATAGTTCACTTACACCTAAACCCAAAGGAAAAACCAGCTCGAGGTCCAATTGTTCTGCTGTAATCGATACCTCAACCTTGGGGCCAGCATCTCCCACTGCCTCCAAATATTAGTAACTACCACTGACGTCCCAGAAGTTTCTGGTCTACCACACTGCCCAATCCCCAACTCCTCCTTCCTGAAGGGCCCTCCCAAGGCTACATCCCCAGCCCACAGTTCTCCTGAGAGAGATCAACCTCCCTGAGATCAGCCAAGACAGATGTGAGAGCAAGGGCCACGTACCCCTGCTGCTTCAGAGGATGTGCCCTCTCCCCTCACTGGTCCATTGGCATGAGACTCACCCCGTCTGCCCAGTAAAAGCCTTTCTGCAG + KKBF2<9?HJ-KHKFDKIKAKEKIKJKJKIJIJKKEKKJIIEIHGK$GDECJJ@KKKKKBHGKKHKKJIIK>KKCKHCAH?BKKKKKKKGKIKJKEJK=BBFIJKJJHKKKJBHJCKK>D9KFHKGHIKJKHFI7EJKKHKKGKKBDJHJIJHIHKI>KKKKHFKFKCJKKJ9KKIDKKJKEIHIB+KBGJ@A36GBFKKK@KKJKK:DKJJDKHKJKK:KK@J:JJJKJIAJKIDJFDJKJDKKJJHJJK8KJK>KJKJKBHKHJHJI;FFF;DH>?B7FA0HD7G?@?EJIGEKK3KHFJHK9GKJKHHJEKIKKK@JJ+JKKKDKJKAKK2KGJKK,KJKJKFKKKKIHHFJKJKIKJHKIAJKAEIJ>FKKGKJIAIKFFFC=KHJKKFKKJJIKIGJIE7E>F7DJEHFKJJ@GJKIJGH8:EJKEHFKJKGKHEFIIEKIIKEKJKJEH?IKHKHKKJJKKKEBCJJJD=IHKBHCGBFI9E>JJEJFJGBHDBD'KGI@CKKEGE=BHGJHKJK=HJKJKKIKFKHIH@KHKKCEHD?KKAGKKIIK?>K6KJJKEIJHFKGFKHJCDIHGJJJK9KKEKJKIKIKKK;@KKKK2JKKJKKJ8KIJJIAKIKKJKDKIKJEKJCHKJ:JJJIJFIICIBHJ7JKI3HKJ1?KKKGKKHJJIJFBKCK4HKGHKJIKJKEJDKFJF?IJJJIKBKK>BJ5HIIKKKKKBKKBKFKIIIJIEKK?KDKKJBDCGCJKJKCIJJ:KKGHFAHH4HKKKKGFJCBIJK9EKKKKFJ9JKGHKDHIJKGKJKKKAKKKDFEGHKHIJKK@IGHBFJBKAKKKJKKKIJJIKKHKKKKKKKKKHHKKKFHEKK?JGBBKHKKJKJKGFIJJIKKKKGJII6CKKJKAKJ*KBJHEIJFKFA@KFF>IJFKGJKKIFKJKKBG$IKIGKFEIH1KKBKGKKCKH>JIKKKKKKKKKEKIGJIKHI4IKKKFGJHKKAKJKKJKJIKCEKK;JK;KKHKAKKKKDKEDJJIKJJKKGK;KKDHIKKIJJK?JKKJKKKGJKK;JKEFJKDKIJ@K@ICI@EJK1=BHKKF%JKEJKJDEKCFJDKHJEBDC?JHJJIJKJ2JIIIGKK;CGKKKKAJKIIK=JKJKHI @rCer/351/1691_62_CCS ATGGGGATGCCCCAGTTAGACACATCGACATGGTTCACCACTATTATGGCGATGCTTCCTACACTATATCTTATCGTACAACTAAAACTACTAAACACGAACCACTACCAACCACCCCTTACAAAAAACCCTACCCTTCAATCCCACAACATCCGCTGACAGCCAAAATGAACGAAAACTTGTTTACCCCTTTCTCAACCCCAACAATTTTAAATCAACCCGCCACAATCCCCATTATCCTATTCCCCACCCTGCTAATCTTAACCTCCAAGCACCCCATTAATAATCGACTAGCTACCATTCAACAAAACCTGACCCGATTCACCCTAAAACAAATAATAATAACCCACAACGCTAAAGGACAAACCTGATCCTTAATACTAACATCCCTAATCACCTTTATTGCTACAACAAACCTCCTAGGACTTATGCCCTACTCGTTCACACCAACTACCCAACTTTCCATAAATCTAGCTATAGCAATCCCTCTATGAGCAGCCACAGTAATAGTAGGGCTTCGCTTTAAAACCAAAAACTCCCTAGCCCACCTCCTACCACAAGGCACACCCACACCTCTCATTCCCATGTTAGTAGCAATCGAAACTATCAGCCTACTTATTCAACCAGTAGCTCTAGCCGTACGATTAACCGCAAACATCACAGCCGGCCATCTGCTAATACACCTAATCGGAAACGCCGTACTAGCACTATCAACCACCAGCCTCTCCATAACCCTGCTAACCTCCACACTTCTGGTGTTACTAACCACTCTAGAAATTGCAGTAGCCCTAATTCAAGCCTATGTCTTCGCACTCTTAATTAGCCTTTATCTACACAACAACACCTAATGACCCACCAGACCCACGCTTATCACATAGTTAAACCCAGTCCCTGGCCGCTGACAGGAGCCCTGTCAGCCTTCTTAATAACATCCGGCTTAGTCATGTGATTTCACTTCTACTCTACCACCCTGCTAATACTAGGCCTACTAACCAACACACTAACCTTATATCAGTGATGACGTGACATTGTGCGAGAAAGCACATACCAAGGCCACCACACAACACCCGTCCAAAAAAGCCTTCGATACGGAATAACACTGTTTATCATCTCAGAAGTATTCTTCTTCATCGGCTTCTTCTGAGCATTTTACCACTCAAGCCTTGCCCCAACACCCTGCTTAGGGGGCCAATGACCACCAACAGGCATCACCCCTCTAAACCCCATAGAAGTACCCCTCCTAAACACTTCTGTATTACTTGCATCCGGAGTTACAATCACCTGAGCTCATCACAGCCTCATAAACAACGATCGAAAACAAACAATTCAAGCCCTACTCATCACAATCCTACTCGGCACCTATTTCACCCTACTACAAATCTCAGAATACTTTGAAGCACCCTTCACCATCTCCGATGGCATCTACGGTTCAACATTCTTCCTAACCACAGGCTTCCACGGACTCCATGTTATTATCGGATCCACATTCCTCTTTATCTGCTTCATCCGCCAACTACTACACCACTTCACATCGAACCACCACTTCGGCTTCGAGGCTGCCGCTTGATATTGACACTTCGTAGATGTTATCTGACTACTCCTCTATATTTCTGTCTATCTGATGAGGAT + JKKKK8JKKKKK5GJKFIEAJKJGKKJKKKBJEJAKJKHJKGCJCHHKHKKJIKKKJKCJHKKKKJKDHJKCCIJJB=KJKKK?KKKCBKKKK:GKKAKEJBKKKKCJKJJJKDJJHK9JK?5KJJGGJJJKKKKGKHKKJJKKK9KHKKKKKKKHKHKGIK?CGKKKJKKJDKJH@KK4JJJ8KHIKFHIJKFKKK/KJDHKJKKJKIKGKJDKKKCIKKKHAK:KJDEKJKKEKKK:JJKKKK8KFKKKK>KKK6EK5JKJKJKJIKKEKJJJJHJK6HJJIEEJBIIKHKJDKJJ=IJIKK7JJBHJKJKFI5JDIKKKKA@C:JGHIKJHDGGAFKHGKK9KKIKJ3IKIEJBGI.JIIKGAHDKKKK?KKKHKJ=KKHHIIHKHIKFKHKKIHJKKKKJKKKGJJKKKJJIIGFJCKDFF6GDFKKKIJHIKKGHG?K6KJJK4KKKK@IIJKFKGCK7JKA>9KIJJI?BJK@KGKIKEKKKJKJKIKKJJJKJBC>GAHCE/GKKKJI>KJKJKJKKK=>KJKK>KKKICJKKBJKKIKFKFKKKJKKK>KKIKJKKKHDHKBHHKKIKKKKJEKKD@JJ5KJBDKKKKKIIKK?KKJKKJI?JKKHKFKJJKKIDJKDKKJJGHJKJIJDDEIKK0KK@KIBKJGKIJIKHKJKKKEKK=KCKICK3HKKIK8KK2KHKBHKDKCIKBKE;JIKHJKGKBKKKKKJKKJIKJGD=H>HIKKKI8KIJKJJCKJKKKKJFIKKKIH=EFEK?BKKKJJKKCKJK1KJKIJ1IAJIKKGKGKJDKHCHKDJKJKI:KKHK>KHKKGJJJHKKJKKIDGGKKJKJJ>GKKKHK?KIKJKKHDJIBJIJJJCGGIK@KKJKKJH6&'+>..4)2&@ @rCer/352/27_1749_CCS GCGCTTCTGCCCTGGCCCTCTGCGGGCCGCTCCGCCGGTGCTGTTCCTGGGCGCCTCCGTGCTCTCGGCCAACGCCTCTGAGAGCGCCCACTCGAGCGCCCGGGAGCCGGAGGGCGGCGGTCCTCGCCGGACCCTCCTGTGGGCCCAGGGGGACAAAAGTGGCTCTCAATCCAGCACATGCACATTGAAGCAAGTTAAAGGATTTAATATGAAGCACAGAAGCAGATAGTGCCAAATAGCAAGCAGTAGTTGGTACAGCATTTGGTGAGTGGGGCAACATTTCCTTCTCCTGCTGCTGAGATGGCAGAAATTAGTCGAATTCAGTACGAAATGGAATATACTGAAGGCATTAGTCAGCGAATGAGGGTCCAGAAAAGTTAAAAGTAGCACCACCAAACGCTGACCTGGAACAAGGATTCCAGAAGGAGTTCCAAATGCTAGTGTGATAATGCAAGTTCCGGAGAGGATTGTTGTGGCAGGAAATAATGAAGATGTTTCATTTTCAAGACCAGCAGATCTTGACCTTATTCAGTCAACTCCCTTTAAACCCCTGCACTAAAAACACCACCTCGTGTACTTACGCTAAGTGAAAGACCACTAGATTTTCTGGATTTAGAAAGACCTCCTACAACCCCTCAAAATGAAGAAATCGTGCAGTTGGCAGACTAAAAAGAGAGCGGTCTATGAGTGAAAATGCTGTTCGCCAAAATGGACAGCTGGTCAGAAATGATTCTCTACCTGTGTTGCGTGGTGGGTCTGCTGCCCGCCACTTCTAATCCTCATCATGAGAACATCAGGTATGGCATTTCAAATATAGATACAACAATTGAAGGAACGTCAGATGACCTGACTGTTGTAGATGCAGCTTCACTAAGACGACAGATAATCAAACTAAATAGACGTCTACAACTTCTGGAAGAGGAGAACAAAGAACGTGCTAAAAGAGAAATGGTCATGTATTCAATTACTGTAGCTTTCTGGCTGCTTAATAGCTGGCTGTGGTTTCGCCGCTAGAGGTAACATCAGCTCTCAAAAATATTGTCTCAACAACTGGAAATATAAAAGATTTGCAAACTTCTTTGTTTCTGTCTCTGCGTTGTATGCCATTTTATAGTCCACTCCCTGAAAATGTATTTCTTCCAGAAAGTCTGGAGGAAGGACCTATATTTTTAGAAGTGAAGGTATATTCTGTCACTCAGCTGTATTCACGTTTGAGCAGTTCTGCAGTACAACCTGCTTAAAATTCTCCCTTTGCATGTTTTGTAAATAGGCTCCAGTTTTGTTTTTTAAAAGGAATTTATTTTTGCCTCATCAGTCCACACAAGTGATTCTGAATAGGAGAGAGTCTGTAGAGAATTGATTTAGATAAGTGTCTGTGAAAGAAAAACAATTTTTTTGTCCTGTTTCTCAAACACTGTTAAGCAGTTTTGTTAATAGACATTTTTGCATCAACACTTCAACATTAACACTTTCAAAGTCATGGTCTGGTGCCAGATTTGAGAAACTCGAACACCTAATATTTCATAACCTTCTTCATTAGGTACTTGTACAGATTAAGTTCTAACATTTCAGCAGTTTAATATGTGTGCAATATGTGCATTCTTTCATTTTAGTTTTGCACTTGGTTTTCTATAACGTACGTTTTTACTCAGTTCATGTGTGAACAATTTAAAAAAGTACAGAATAAGGTACAAATGTAGTGTATTTAATAAACTGTCAAGC + 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@rCer/353/24_2109_CCS ATGGGGAGTGACTTGAAGGCGGGGCAACAAAGGGTACGGCCGATATGGTGCTCCTCGGCCCGCGCTTCAATGGTTATGACAGTGTTAACTCTAAGGGGAGAAGGAATGTGTGACCATTAACAACGGTTAACTTGCATTCCCCAGATAGTTTGGATGAGTTACAACCCAAATCTGCAAACTCAATACAGCCAGACCCTGGGAAGTGACCCTCTCGAGCCTCCTGTACAAGTCCAGGAAAAAGAGCCTGTTTTCCCTTGGACAACGTGAGCAGTGAATTACTGCTCATTCAGAATTACATGTCATGTGTTACTGATGGCCAGGTTTAGATACCAACCTATTTCTAGAGGAGAGGTGATTTGATAACCTTTTCAGATATCACTATCACTAGGCAGAAAAAGGGTTAATACTATGACAGTGTCCTGAGGACAGTAGAGAAACTGCAAACTGCAGAAGTACCTGATCTGTGGCCCTTGGCCAGCATCTCTCCATATCCTGATTCTGTAAGATCAAGTGTTTATGCAGAAAGAGAAGGGACCGATGATTTGAATGTGACCAGATGTATGGCACGCCCTTATTGCCATGCCAGCATTTGCTATTCATGATGTTAGTATTCAAAAATCAAGAAACACTCTGCATGGGCCATTGGTGTCTACTAATCCAATCCGTTGGAAGAAAAGACTGGAATCCACCACTTACTAGCTCCTTGGGCCTCAGTCCCCTCTTTTCTGCCATAACTAAGGACCACCTAATCTAGATGGCTGCTGTTATTGTTCAAAGGAACATCTTTAGAGCCTCAAGCCCAGGAATAGTCCATGGCAGGCACCTGGTAAATGTTAGTTTTCATTGTCCTCTCCCAACACTATGAAACATGCAGCACTCTCTGCAACTGCCCCTGTGGATTTCCATAGGCAGGAGAGCATCTAGTGTTGAGTGGAGTGGTATTCTCAGAAACGAAGCCCCTTTCCTCATTTTGTGCCAATCTCTTCAGTCATTTGTACCCTAGTAGTATAGGGCTTTGTCAAAGTCACTGTCATCTAATGTTAACAGTTGTTTTTGCCAGATGACTTTTTCAAAAAGTGACTGTTAATGTGATAAAAACACTGCATGTAGCCAATTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTACTGCTCTTGTTGCCCAGGCTAGAGTGCAGCGGCGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTATTCTCCTGCCTCAGCCTCCCAAGTGGCTGGGATTATAGGCACACGCCACCATGCCCAGCCAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAGGTGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCCAACTATTTTCTTATTTGTTATATATTTATTTTAGAGATAGGATGCCATTATGTTACCCAGTCTGGAATGCAGTGGCTAATTAGAGGCATGATCATAGCATACTATGACCTCGGCTCAAAGGACCCTGCAACCTTAGCCTCCTGAGTAGCTGGGACAAGTGTGCACCACCACAGCTGACTAATTTTTAAATTTTTGTAGAGATAGGGTCTGGCTATGTTGCCCAGGCTGGTCTGGAATTCCTGGACTCAAGGCCTCTTCCTGCCCTCAGCCTTCCAAAGTGTTAGGATTACAGGGTGAATACCCACACCCAGCCAGTGTGAATTTTCTAATGCTGAGTAAGTTGTGATCCAGAAGTAAATGTATCTGCAAGCTGATTTAAATTGTAGATTTTCTTCTCATTGTGTATTTTCTGATGTTGAATAAAGTCTGAGTATTAACTAAAGTTTTTCCTTCTTCTTAAATATGTAAGAATTGTCCTCAAAATCTCCATTCTTGAGCACAGTAGTAAAAATATTTTTACATACATTGTATTTCAAGGGTTCTGCATAAACAACTTTGTTTTATTGTGACTAAATTTATTTGGGATTTTATCAAATATATAATACTGAGATGTTCTCATTCCTTTTGTGAAAATGGTCTGGTTTAAAAACCACTGCCTTC 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@rCer/355/2292_59_CCS GGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGCGGGGGGCATGGGCAAAGACTACTACCAGACGCTGGGCCTGGCCCGCGGCGCGTCGGATGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCCTGCGCTACCACCCGGACAAGAACAAGGAGCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCCGAGGCCTACGACGTGCTCAGCGACCCGCGCAGCGCGAGATCTTCGACCGCTACGGAGAGGAAGGCCTAAAGGGCAGTGGCCCCAGTGGCGGTAGCGGCAGTGGTGCCAATGGTACCTCTTCAGCTACACGTTCCATGGAGACCCTCATGCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACATTGATGACCCGTTCTCTGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCCCTTCCCAAGAGCCCACCCGAAAGAAGCAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTTGAAGAGATCTACAGCGGTTGTACCAAGAAGAATGAAAATCTCCCACAAGCGGCTAAACCCCGACGGAAGAGCATTCGAAACGAAGACAAAATCTTGACCATCGAAAGTGAAGAAGGGGTGGAAAGAAGGGACCAAAATCACCTTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCACACAATATCTTTAAGAGAGATGGCTCTGATGTGTTGATTATCCTGCCAGGATCAGCCTCCGGGAGGCTCTGTGTGCTGCACAGTGAAACGTCCCCACTCTGGACGGCAGGAACCATACCCGTCGTATTCAAAGATGTCATCAGGCCTGGCATGCGCCGAAAAGTTCCTGGAGAAGGCTCCCCCTCCCCAAAACGCCCGAGAAACGTGGGGGACCTCATTATTGAATTTGAAGTGATCTTCCCCGAAAGGATTCCCCAGACATCAAGAAACCGTACTTGAGCAGGTCCTTCCAATATAGCTGCCAGAGCTCCGACTGACCAGGGACCTTTCCAGAGCTCAAGGATTCTGGACCTTTCTACCAATTGTGGACCATGGGAGGGCCCAGGGAGGACTTTCATACTGCTGAATGTTTTCCAGAGCATATATTACAATCTTTCAAAGTCGTACACTAGACTAAAGTGGTTTTTCGAGCGATAGGGCATCAAGGTGGTGGGAACAGCAGGAAAAGGCATTCCAGTCTGCCCCACTGGGTCCGGCAAGCCCTCCGGGATGGGCCCACATCCTCCTCCTCCAGTCCCTGTCCAGGGGTAGAGGCAGACCAGCAGCTGGGCTTGATCCCTCTGTGTCCCTTTGCTTTGACTGGTAGATAATGTCGACCTGCTGTCTTGGTTCCCAGACCCCTGTACACTCCTCTGTTTTCTGTTGTGTGGATCAGTTTCGTGTTTAATTCTGTATTTGTCCTCCACATGTCTTGCTCTTCCTCCCCTGGAGAATTCGTCCTCTCTTTGGCCATCTCAAATTGAGAACCTAAAGTATTCCTGCAGAACTGGCCTGGCTGGCGCCCACAAGCAATACCTCTTGTTCCAGCAGGACCAAGGGAACCAGCCTCCAGCGAGTGACTCCAGCAAGCGCAGCCACCTCTGCCTTGAGTGTCCGGGAGCCTGGCCCCAGCAAGGGCCCTCCTGACCTCTGGCTCTAGTGAAGCTGAATGTCCTCACTTTGTGGGTCACATTCTCCATTTCCGTAAGGCCAATCTTGGCACACCTGGGGCTTACAGTGGCCCAGGTAATTTTTTGTTTCATGGACTATGGACTCTTTCAAAGGGATCTGATCCTTTTGAATTTTGCACAGCCCTAGATATAATCCCTTTTGATAAAAGGGTCTTTGCTTCTGATTACAGGAGCACTGTGGAACGTCTGTAAATGATGTTATTTTATAATTCCATGTATAGTTGGTGTACACTCAAATAAAAACCTGTCCCCGGCAGCCACTGCTCTCTGTATAGGGCCATAATGAAATTCTGAAGAAATCTTGGGGAGGGAAGGGGAGTTGGAACAAATGTCTGTTCGCTGGAGGCCAGTCTGGTGCTCAGACCTTTAGACTCATTGTAAGTGCCACTGCCAACATGAGACCAAAGTGTGTGACTTGTCAATGCAGCGCGACAGCATTAAAGACTGATGCTAAAC 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@rCer/356/0_1730_CCS AGAGCTGCGCAAAGCGGAAGACCCCAGTCCAGATCAGACTGACTCGCCAAACCATGAAACCCGGCCATCAGCATCGCCTCCTGCACATCTTGCAGCTCCCCGAGGGCAAGAAGGTGACCAGCCTAACGGCTGCCTAGTGACCAGAGCCTTCGTCTGACTGCCGCCATGAGAAAAATCCACCAGCTCACCCATCCAGTACGAGTTCAGCCTGACCCGTGAGACAAAGAAAGCACGTGCTCTTTGGCACCGTGGGGTGCCTGAGCACACATACCGCTCCCGAACCAACTTCACCAGCAAATACAACATGAAGGTCCTCTACTTATCCGCCTTCACAGCAAGGATGAGGGGACCTACACGTGTGCACTCCACCACTCTGGCCATTCCCCGCCCATCTCCCCCAGAACGTCACGTGCTCAGAGACAAACTGGTCAAGTGTGAGGGCATCAGCCTGCTGGCTCAGAACACCTCGTGGCTGCTTCTGCTCCTGCTCTCCCTCTCCCTTCTCCGGCCACGGATTTCATGTCCCTGTGACTGGTGGGGCCCATGGAGGAGATAGGAAGCCTCAAATTCCAGTGCAGAGATCCTACTTCTCTGAATCGCTGACCCCCTCCCACAGTCCCTCACACCTCGAGGAAAGTGGGGACCCCATCCCTCATCAGGAGTCCAGTGCTGCATGCGATTATCTACCACATCCCGCGGCACCTCACCCTCTCCACACACCTCTGGCGTCTTTTGTACTCTTTGTTCCAGAGCTGCTTCTGTCTGGTTATTTAGGGTTATCCTTCCTTTCTTTGAGAGTTCGTGAGAGGGAAGCCAAGATTGGGGACCTGATAGAGAGTGAGAGCATGTGAGGGGTATGGGATGGTGGGTACCAGCCACTGAGGTCATCCTTGCCCATTGGACCAGAGACCTGGGAGAGACTTGCATGAGGAGTGGTTGGGCTGTGCCTGAACCTAGCACGGACACAGTCTGTCCTGAGAGCACTCCTCAGCAGGCATGGCTGGTGCCTGAAGACCCAGATGTGAGGGCACCACCAAGAATTTGTGGCCTACCTTGTGAGGGAGAGAACTGAGCATCTCCAGCATCTCAGCCACAACCAAAAAAAAAAAAAATAAAAACAGCCCTCCTTACCACTGTGCAAGTTCCCCAAGGGCTTTGGGCATGAGCCGGTGAAGATGCAGGTTTGACCGGAAAGCAGCGCTAGTGGAGGGTTGGAGGAGGAAGTAAAGGATGAGGGTTCATCATCCTCCCTGCCTAAGGAAGCTAAAAGCATGGGCCTGCTGCCCCTCCCTGCCTCCACCCACAGTGAGAGGGCTACAGAGGAGGACAAGACCCTCTCAGGCTGTCCCAAGCTCCCAAGAGCTTCCAGAGCTCTGACCCACAGCCTCCAAGTCAGGTGGGTGGAGTCCCAGAGCTGCACAGAGTTTGGCCCAAGTTTCTAAGGAGGTACTTCTCCCCTCGCCCATTCAGTGCCAGCCCCTGCTGGCTGGTGCCTGAGCCCCTCAGACAGCCCTGCCCGCAGGCCTGCCTTCTCAGGACCTCTGTGGGGCCGAGGCAGGCCATGGAGTGAGACCCAGGAGCTGGACACTTCTCGGGAAATGGCTTTTCCCAACCCCCAGCCCCCGCCCGGTGGTTCTTCCTGTTCTGTGACTGTGCATAGTGCCACCACAGCTTATGGCATCTCATTGAGGAAAAAGAAAACTGCACAATAAAACCAAGCCTCTGGAATC 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S($%'#$($%"%'((%'()$&))))),'&),+(%#$$*),,'#)($(*&#&)(%&'#((+*.'''-*+&+',',--($---++)")$#$$'((+&"%'*--,++-(,%)'$*#)(&*$-)(')+%+&))#(*)-0,(($%0.--++,0)()0,*,&.1/-+-.*,*'(+&$'$+()',/)*&+**)*$(#%**/&)*.-)*&*-1)/'21,*-..+//.111-./+%/)+./,-./0.1*.+&+-0)-,.$)+($'%.&)-,(+/)*&.*--,,-%/+&$$*+&/+.-11,210,((+-*-&&'..+%+$)/,1-/%,-+)/(').-1&+//$##))1,,)+%(()..01201.1.%(0111.,+,0,+110,--(//-1),*21,'))-*&+-*-(2414*4-2-25.#'+0,2*$0#'0066.+01.403-/03*&%+./,/,)&.544)/&3434.2',+,*3324.(51055003-041.541**14126/(/)/2/420%%#+'30,#+2)022-&&.,03-/-(.31/4/)220%0.13565.0.&-1222061.1+4&1/45/501026652302/64453511455+302$+-00(3),/0+////,(&/46.3,/,124640)+'$0)2/643/,0*.)/(34450/.&.2.,/)/310..(*3,33613%.2-40.%1,),4$34%++*0)/60//)+'-/+,4-211.16/40*12$*.&01./325.41664045641-4./44.1-41.,//.#-,*145.62)32205+1*,%53//(,,13(-155452%)*&/%#/+)3&$*0+-*2314+2,'',110/3,31.-'+-0)+.2-&.0*++$+-1'+(&&$'*+./3,.(00-'$(%-)),+,+*2/$.+,$().'/4+(*./(/0)13.(./41(/.,)-03*+1/.+1'.*,+-+(/&'+)*/0-0,//+-+/30/13213.01453/20),0150043-41322%.2/*./../-%.,315132-$**(.12534/3.50/)+%&*((0*1/6221#*+$)&+1/4+*/13535411(/22-48:421*7+5:9)'.8764.138.524#564/01.//2212/04356641&01/.0,21'/-217325+2007'4/1-/+875(14&752458420:'037314&7960/508459*+$7,4124257579:99,/*'0207/5636006)0+./:55966/1%5/+944/-32&12-14/),63,737474:4*84*.-.0%01)-33/13%40-2'4/)2*1--3/36466,0.#/23,454.6:877)311445.95.+7533/45$,1,41/:945544&2/.5(3.6-7075175917955.60.654-7/527;448,/25%2(*04/54'84.629/9:3--4846'6727-560:2(3127*5%($1:287*,%)'%)0+,,-132$27:2,53:52%888.245,:48,659,99>>>/;??=8>65:>:%61.+%0-440.0/94*6:.=&990#8*.<9<67/(<7(%075'683.48<<88;>521::605-968249807409599449'4*)355'36'76.)3/(30583125+2316/03:)8947291-3+89586954.879242-'153792*44/5-3+,,+-0,1;3+7+'-.4:8*'.)9652104526795-4-67-7332525109683%.-.38 @rCer/357/25_1841_CCS ATGGGATGGCTGGAGTCTGCTGTTGTCAGAAGGCAGGGAGGGTGATGAAGGACTGACCCACATGGACTGGGATGTATGTCGGGTATGGGCATGACTGCACACTCACTCTCGGTGGGATCTGGGCAACATGGAGGAGTTTATGGTCCTGTTGCTTACTTACTGCAATGTCTTTGGCCCTCCTTTTCAACTGGTTCCTTTGTGGGCCCAAAGGTTGGGAGTAGGAGACAGTATCCCAGGCTGACAAGGCCTTGCCCTTTACCTTGGGCACCTTGTTAATTTTAGCCTGTGCCCTTCCCCACCTTTGCCTTCCCAGTGGTTGGTATGTGGGAAGCCCATCTCAGTTCTGTGACTTCATGTCTCAAACCAAGGATGAGCGTCTGGTCTCTGCTATGATGGTGGTATCTGAGGCCTTTCCCTGCCCAGTCTGGTGCCTGCCCCACATTGTACCAGACACTGGATTCCTGGATCCCCTTCTCCTTTCCTTTCTTTCCTTCGGGTCACGCAGCCCTGTACTGTATCCAGCACCACAGAAACCTCAGTGTTTTTCGTCTGCTGGTTTGGGCACAAGGAAGCCTTAGGGTATGGGGAAAGGCTGTTATTACTTAGAGTTTACTCCCAGGCCAGGGGGCTGCCATCTTTTTCACAGACATCCTGAAAGGAAGCCCCTTTGGGCAGGGAGCGAGGACTTCATCTCAACATAGGCTGGTGGTTGGTAGGGGAGCTTTTTCTTTTTTTCTTTTCTTTTCTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTAGGTAACATGTTAGGAGTTAATGTTGCAAAGAGTAGTTTACATCTTCACTTTCTGAAGACACTTGAATTTAGGACCGATGTATCTGTGACAAGCATGCCAGAAGTGGCAGGGGCCATCAGGGCTAACCACTTCACACCCACCATCCTCCCATGGGGATCCAAGACCTGAGATAAAGCAACAGCCTGCCCAGATCCTCTGTTCATCCTATCCCTTCCAAGGTTGGTCCATGCCAACATAACCTCTGGGCATCAGACATCAGCAGGTCTGTGTGCCTCAGCCCTGTTAAGGGGAAGGTTTCTCTTTCGCCCTCTTCCTGCACCTGGGAGCAAAGGCACTACCAGTAGAGAAGGGCCATCCAGCCCTGCCCCAGCCTGGACCCCTGGGGCTCAGATAGAGGTGCTGAGCCCCTATGTCAAAGTTGTTAAATGTTTTTGTTTTGTTCCATTGTAGCTCTTTTTTTTTTTTTTTTTTTCCCTTTCCTGGTGATTGATTTTACAAAAGAAAGTAAGCTGCTTAGAAGGCCCTGGAAGGAAGTGAGGAGGAGGGACAAGGAAGATGACTAGTTACGGAGGGTGAGGGTTGTTTTTTTGCCAAAAAAGCCTGGTAGAGTGATCTGAATTATCTGGCACCCTCCTGAATGGAACCCCAGAGTACCTCCTGTGTGGAAGGGTCCCTGGATTTTCCCTAACACCCACCCTCTCCCCTTCAGCCATGCTGATGGCAGAGAAGATAAGAACTTGGAGCCCATTTCTCACTGGAGAGGAAAACTTGTCATCTGGCTTTGCGGAGAAGGTTCCACCTTACGCTCGTAGTACATTATCTTTACTATGTGCTAGGATATCATATTTAAAAGGACAAAAAAAAATGTAAAATACTTGAATGAGCTTGTATTATAACATTAATATTATTGAGAGTATCTGCTTTCCAGGCTGAAGTGATTCATTCATTATTCTAGTCCTGCTTTAGTCCTTTGTAATTTGTGGTAATTATGCTTTTCTTTTTAATACAAAAAAATGTATAAAAATAAACACTTGAAAAG + ;A+EDE=@GAEDAA>CA=EGEFCDFFEDABF3EAC9FFCDBA>DD=D<@;B:DGEE>A>+EEC>=8EGBEFAAC?BF?FF;:?>C=;=C5G;'DD=CEB8EFDCFA<=8>?<@7>?ACF?5E;BGEC-FEE>C=E5G5CEFA@DCFCD69B>F7GB?5E1@CDD@FAC@C6B=E<6@CAC==AC=@E?1CGE:B9BBCD/E*D.?2FB8GG3CDB4C2A6EFCC=@=EF@F85%=AD8;4:@CFF>HG>C2GIFADI/@AA;I8E>II?ECIFH=IJ2IH>C>JJDAEGHIJ@E=FAH0JJJCDI@DIIEAJC=;7GF@DGFBFBJHHJII4IJE1B=GGJAIGBICGIE?IJ7IDIF/GHHGCIBD@H@JEHGCIH8CEA?5GGICIFJ?GE@6EHBFHH7DEE'DDG>?>?<9H;(DCFEG=H:EGIBDG?BD1EJDH;'DD@GFHECIDDJDBEH7(HCF>CGEF:F:;IGC7F?A4E@F.HHEDGA&AADABG?GA@-HHCGEBFIAEDI4FGI1I@E@?CBEADGCIGHFBI@IEEEJ0ACJ=E2IFF>IBIIIDIIBGEJ@JHFFIC.B?(BFC9EDG6G/$?ACB.EGCFD;G=GIDDGH?DGDB;BGFFEJBF:9@CIEG<&G>?=AEHHAGDGFDC9JHBJ>J9JGJHI5>9=IHGF8H5F9;@?IBE?HH@GJHFFC?HIEH6=:E;DD@GH7FDCHGHIJHDAEGI3DACBG?G7GFCFF?BGII)JDCEBG,FHIED:EC'E?A=IDGG>HGCDIHHJIII>@FIADBHJ@HAGCIHGCGF?E=GFJBIFHDAIH6GGHG)IIDED>GIIHACD>G?GD?D7?+EDGHHAHGIAFGG6GA:FAIIA@J<,C;)E+(A?DAIDEBDDDEFFEE0G=GCH>0AD=29:IE'?EBCGGHAH7GGBHHG>CB%H53>BEDIHD=DHBJ9EDFFE8HHA3JIH>FAC8HFEJ7G/IGJ;GIII>6HE;IHEIIH0DCJ,B?FFJIEGFBE8*FHH3=H=?DJGD?@:C:?6@FADFCBBCA@;FC1DC@HAJBG9GG@1FC=G<@E?>I?ACD:H5FB@I3IA>>CEGI>8HH?IIJFJ?H,IHHJJEFHIII>IIEF=H*CC3BDBCEE?HEEC;=AE(?B/ID>EGI=1D'5DFFCGICIHCI2IJGHD>F>HG?BBE9DGGC;HBAG5E:7HF;HFC?/;HEFAGE;C2AHIGDA>GCF9,<>E:EAFJACFFJA$HHEA @rCer/360/25_1681_CCS ATGGGAAAGAGAGAGGGCAGAGAAAGAGGCAGCAAGAGATTTGTCCTGAGGATCCAGAAACCCATGGTACCCTACTGAACACCAAATCCCCTGGAAGCCCACAGAGACAGAAACAGCAAGAGAAGCAGAGATAAATACACTCACGCCAGGAGCGCGCTCTCTCTCTCTCTCTCTCTCTCCCCTCCGCTTCCCTCCCTCTCTCTCTCTGCCTGTCCTAGTCCTCCAGTCCTCAAATTCCCAGTCCCCTGCACCCCTTCCTGGGACACTATGTTGTTCTCCGCCCTCCTGCTGGAGGTGATTTGGATCCTGGCTGCAGATGGGGGTCAACACTGGACATATGAGGGCCCACATGGTCAGGACCACTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGACTTGCCTGCTCTGCAGCCCACGGATATGACCAGCTGGCACCGAGCCTTTGGACCTGCATAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCCCGAAAATACGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGCCACAGTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTCAGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAATCAGCCATAAAGATCAGAAGACCTCGGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCCCACAGCTGGAGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTCTATAGAAGGTCCCAATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTTCTCCACGGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCCTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCAGCCAAGCGGGATCCTTGTACACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGACTGTGGTCTTCACCTCAGCACGAGCCACGACTGAGGCATAAATTCCTCTCAGATACCGTGGATGTGGATGACTTCCCCTAATGCCTATCGGGAAGCCTCTAAATGGGGTGTACGGTCTGGCCAGAAACACTGTAGAGTAGTAGGCAGATGTCCTCCTTCCCCTGGACATCTCCTACAGAGAGGAATGGACCCAGGCTGTCATTCGAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAAATGAGGAAATCCCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGATATATCCCAAAGTCCTCTACCCCCTTACTTTTATGGCCCTTTCCCTAGATATACTGCAGGATCTCTCCTTAGGATAAAGAGTTGTTGTTGAAGTTGTATATTTTTGATCAATATTT + DG)JJ*544)4++40;FBF;;=(06?66@9>>JBJC9EF?5;8DFDAH3HBE>J(E/<8IC:FE@8DGD>GF@>C==BBCD5EGHFG@CA7==0+:DC3>HJ<7J-?GB'HE7:,HFKIHJ>;J>=E>DGFABEK@A9GF,D%GHC>8%IIGEJHJ:JKE=K+G@*KHCKEIJBDE:CEFGECJEI2KIE=J:DHCEID@F?;A,FHFH7<>JH=ICCIJ>;51&BEEGJJ5EFKF3AJ=B'+(8DF/BH4AGAD=C5GFD>D>H@B8:37<95?'46C4C4D2D??95*:=DK;CIF3;:-EDBA:<31@FG?99GDB:;*:CB@;HIBDH?@J?AF;CADE=GFC@$FI>ECGA@@@@HDDCB$96DIHEEBE?J8@08FF@A=6D>A>GDCC8D?>>IHD?9>BIJDJH@DJD?HD6>ECH+K&GGE8*H<:BEGF:5F?>G;GKGI>93G=-E?J8DFJ2KF>8FAB'7C/KKJE.JFBDBCF1F,HB=8H@F/>?:A@AFGG:=H@K1C>KCJEGEHAC>4DKIED8JKCGK?1ABFF>A=EJJI+AAK>;??5;?KI8FFHJGGGADH4DJBJF9DEK@KKK=.KH:KDEJG7G@>I>9FKJ@JIKG=GIICF2I?BJKF:9@><9J.KK??HH9:E>7DDD:A35@>5E:8BGIFF>.+4A(:54?B>7@ED@B8;?:AFIH(IJH8GAD0F:HKJ5FAI;GIDEB609CB38HEB6@@,JHJJE7H,DBJ1FFA<>E:JD<GCIB?ADCE97AFHIK;JG@CJ>AI:5F7FC31A?HE?A=GG;7**>CA+CK@H47;<@DFDFI;AI):FHGHJ*BFF>H/G?>HIA5EBCEI9=IJ?JFAE@FF32$F=AB>=@AADF=B@DGA:@G>@+>AA=5=)3>>CB=3@92CGHH8ABCGFHI;HIAGDJE@.>?>@E:A??,CI9FDHFH3JI?BJF6FAEA6FH>(C?=HH:>BGJFED?G;I3=?9A*;8BC4==.HH@-CF>CA?+AA5@(9;>=?C:42CB4D?8=89<4@EDF=HFHE:GA=7C<>A@EI4GH=@EF6?46-BICB'@?:28B@@D;GEGI3AF$6?B?GD?9@@EBADDHD:</>?9CB+A52@A7FC98;8/7?:8>?CD:$,7+1@ @rCer/361/25_1632_CCS ATGGGAAAGGATACCCGGTCTCCGAAGTTCATGGCGACGCTGGTCCTAGTACCCGGACGAGTTATGCGGCCTCTGGGTGGCCAACTTTGGCGCTTCTTGCCTCGCGGACTCGAGCTTTGGGGCCCAGCCGAGGGGACTGCGAGAGTCTTGCTGAGGCAGCTCTGCTCGCGGCAAGCGGAGGTGTGGCGTGCCTCGGGGCTCCCTGGCTACTGCTTAGGAACCCGGCCCCTCAGCACGGCGAGGCCGCCACCCCCACCCCCGTGGTCGGAGAAGGGCCCCAGAGACTCCACGCGCCCTCGAAGCCCGGGCCTGTTTCCTGGAAGTCTTTAGCAATCACATTTGCTATTGGAGGAGCTTTATGGCTGGAATGAAGTACATGAAGAAAGAAAAGGCAGAGAAGTAGAGAAGGAACGGCAGCGACAGATCGGCAAGCCTTTACTTGGGGACCCTTTCCCTCACAACTCATACTGGGGAGCATAAAACTGACAAGGACTACTTGGGTCAGTGGTTATTGATTATTTTGGCTTCACTCATTGCCCTGATGTCTGTCCAGAAGAACTAGAGAAGATGATTCAAGTCGTGGATGAAATAGATAGCATTACAACTCTGCCAGATCTAACTCCACTTTCATCAGCATTGACCCAGAGAGGGACACAAAAGAAGCCATCGCAAAGTATGTGAAAGAATTTCTCCCAAACTGGTTGGCTTGACTGGCACGAGAGAAGAAGTCGATCAAGTGGCCAGAGCATACAGAGTGTATTACAGCCCTGGCCCCAAGGATGAAGATGAAGACTACATAGTGGATCACACAATAATAATGTACTTGGTTGGACCAGATGGTGAGTTCCTAGATTATTTTGGCCAGAACAAGAGGAAGGGAGAAATAGCTGCTTCAATTGTCGCACACATGAGGCCATACAGGAAAAAGAGCTAGCCAAAGCAGTGTTGCTGGATGCAGTATTCTCTTGCTAAGAGGAAGGAAACTTTGTCTCGCATAGGAGCTTATATAAATATAAACATATATACATGCAGTCTACAGAGTGGCCTTCATATCATGAGAACATTTCTGTTTTGGATGGGGATGTTACCTTGCGTTCAACCAAAATTGATTCTTGGAACTGTAAAGTTTACAACCCAAAGTCAGAGGACCAAGTTAAAGTGAAGCCAGTAAAGAACCCACCTGCGGAAAGGACACGGCGGGCGAGGCACAGCCAGTGCATTTCTGCCTGCAAACAGGCCCTTCCAGCAGCTTTCCTGCCTCTCCATTGTCTTGGACCCTTGCTCAAAGAGCTGTGGGACTGAATTTCATGGAAAGAATATGATTTTCGTAGTGCTCCTGCTTGCCTCTTCTTGAGTTCTCTGTTCTTCTGAGTTCTTGGTGGCTAATAACAGATTAGGGTCTCTGCCATTCAGAGTTGATACTTGAAAACTTTAGTTTTCCTTATTAATGAATATCACTATCGGATTTGACTAATGAAGAGGAAATCTATCGTTTGGGGGAAAGAAAAACATCAGTTTGATGTCTCTAGGGGGTCTTTTGTGTGATTTTTAGCTAAGTGGTGTGCCAGGGTTTCAGTGACATACCAAATGAAAATAAAGAGGATATT + GI%J;.KK0C41B@GK1KHCHIIKK@?GFKEGGHKGKKG@K;JDHJ&DDJ>KDKDKKCKKDGKJG>KDJIEDKKKKKGKIKKKKKKJ@KK5KHKEKKKJKKKG(IKIJIJKKKKKJJGKGKKKGJHGKKIJJJKJKKIJJFHKKIKKKKKK>KFKHHKIJJJ@KKK6KKKEKJKKKK,KKIIDCJF7KK?KK@K@I9KKAJH&@EK$KIGFCKH'EF>JKKJKKBIHIKKKIJK8KKF>JHBF%KIJHJJIKJIBKKC0KKJIBIJ.KKGB;G8KJKAGKKIKCKKKK>KKKGJDB?IHKKKHH+KKKHKKK5KKKKKKEK:KK?KKKKJIKJIKKKJKKDKJEKICKKKJKJKKK.K=KKJJKJJCGKKKIKHKJ?IKHKKKIKKK?K?KKKGKHKKKKJKKK>KJKJKJFKKJIJJKFKKJKKKCI=KE?KIFK=JHKKCKKKKKJKKJK@JJKKKGIJJFKJKFGHI0JD&JKJHKFK62?K=1G8ICKJK6KKHK>KKKKKKKKJJKFDK6KKKKKKIEFBFHKJAK@KKJKKHKEHKKBHJF9JGJKI<;GF>BD>8:EEKFFKKKKKKKK3IKKKEK>KJKIKKKFKGJKEJ3KJJ*KKKKK6KKKHKKK*KKKI8JDCG-I:DIKKFKKFFHK>KKKGKKKKKK9KCJJKKK8BDKKJ'KIKJHK1KK=KKKKKHKG@KKFKFKKDK*KJJJIEKKJKKKICKKJEKIKKKGJEJKJKDJI?KIEIGFJI&JKKKI2KKEBHGDKHKJKKGDKKKKJ;CKKK5KKKKFKKJ5KK6KKKDKKKHJBJK@KEKKJK9KKKJAFKKDJKJIG8K @rCer/362/1834_58_CCS ATGGGCCGCTCGACTCGGAGGCTCCCGCAGCCCGGCGTCCGCCCCGCTGCCCCTCCCCGGGGCCATGGGGCGCCCCGGGCTACCGGCCCTCGGCTTGGGTGCATCTCCTCCACCAGCTGCCCGCGCCGACTTCCAGCTCCGCCGGTGCCCAGCGGTTTCGCGCCCAAGAGCAGGAATACCAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGCCTGGCTTGGCCTGAGCCTCATTTTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCGAGCCTCCCGGTCCAAGACCCCTCGCCCGGAGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCCGGCTGCATTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCCCAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCGCCATTGACCACCTGGTGTTGGAGACGGTGGAGAGGCTGGGTGAGGCAGTGAGGACAGAGCTGACCACCCTGGAGGAGGTGCTCGAGCCTCGCACAGAGCTGGTGGCTGCTGCCCGAGGGGCTCGGCGGCAGGCAGAGGCGGTGGCCCAGCAGCTACAGGGGCTGGCCTTCTGGCAGGGAGTGCCCTGAGCCCCCTGCAGGTGGCTGAAGATGTGTCCTTCGTGAGGAATACAGGTGGCTGGCCTATGTCTCTTGCTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCCTCCTGGGCCTGGCGAAGCAGAGCAAGTGGCTGGTGATCGTGATGACGGTCATGAGTCTCCTGGTTCTTGTCCTGAGCTGGGCTCCATGGGCCTGGAGCAGCCACGGCTGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCTTATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTATTTCCTCTGCAACCAGGCCGTCTCCAACCCTTCCAACAGAGGCTGACTCTGTCCCAGCGAGCTCTGGCAACATCCACTCCCAGCTGCTGGGCCTGGAGAGAGAAGCTGTGCCTCAGTTCCCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAACTTTCACCAGTTGGTGGCACTGCTGCACTGCCGTGGCCTGCACAAGGACTACGGCGCAGCCCTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTGCTCTTCTCCCTGCTGTCCGCGGAGCACTGGCCACCGCGCTCTGCAGCCTGCCCCGCGCCTGGCCCTCTTCCACCCAGTGACGACTACGATGACACAGACGATGACGACCCTTTCAACCCGCAGGAATCCAAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGAGCCCCTCCTCCCTGCCGGACTGGACCCTGGCTCCCTCTTCGTTCCTTCCCTGGCTGCCGGAGGAGACCCACTAACCCAGCCTGCCTGGGCTCTGACCACTAACACTCTTGGCCACGGACAGCCGCACAGGACCGCCTCCCTGTCCTTGCCTTGGGAGTAGCTGAGGGGCAGACTAGGGAGTAGGGCTGGCAGGGGAGGGGGCAGACAGCCTCACACCCTTCATCCCTGCTGCCGGTCCCATCCTTGGAGGACTGAGCTGGGGCGGGGACATGAGTCCCCTGCTGCCCCTGCCACATCCCAGTGGGCTCTGACCCCCTGATCTCAACTCGTGGCACTAACTTGGAAAAGGGTTGATTGAAAATAAAAGGGAAGACTATTTT + JKKJ&<@KJKKKJKC#9JEKKK8CKIKK;EK+KJKKK3?5KJKI'KKKKDKK?HKKAKK#JBKKKKJKCKKKKK;KEKKKBKEK?JKJKKKKGJK@KK(K?KHK.DK4>.JK$KKJK'DAKKKKK6KKGKKK8KJKKKJKKKKKCJ;KIGKKKKKKC=JKJFJBJIK)J?IKKK2KKHK-HKJ?I&KKKAKKKKKKKKIJKKI3KKKJ>KKKKJK?KKKKKIJKIJKKJKKKDFDDK;KKJKKFKKEGKKKKKKKK9KKKKKJJKJKJKKFKKIGKKKKKKK?KKKKK.KKKK@KKEKKK1KKKJK+KKAKKEKKBKKJJFJHKKKKKK(KKKJK1KFJKK=KKKKEJI8GJHJK?JH&IHKIK7KCJKB&=FJAKKKIJKKHKK>JKHGKJKKGKKIFI0FDKDIJFJ4HDFFKKIIKKJHKK:KKFG5GJ*JIKJKHKAKGKKKK-CK;KKKK2K(II)K3AKK)JKIKFKK7HKE*HKK*KKK7JJIKK>G1EKIKGJKH)?GKKKKJEJ6JK2KKJ6KK@I>KK&1;KJK&IKKKK(KKKKKJGKFKJK@KKK6KGKKKKK9G%JKKK>J-KKK=KKKKKJK?KI3EIJKJIKKKKI'8EGJ-JJI>IJJKKKK&HKJK@KKK.KKKHJKJFCK3KKKKK)JKKFKJKKKK)KKKGIJKKCKKIKJI7KKKKKIDKEKHKKKHIG&KIKJGEIKKKAKKKKGKK@KAJJGAKHKK: @rCer/363/1798_57_CCS ATGGGAAGCAGTGGTAAGTAGTTTAAATAAAATAAATGATTTCGACTCATTAGATTATGATAACCATACTAACCAAAATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTT + .$-20,,.))(-.--0/0.,.20120+&,+(*+++,0),./'0/-+%*-,'-0.-,/*-0120/./'-)+00.)"#((EG@G:4@<<@8<3;C@><.CB7>AEDB=;ACBDAA?:;5??BAEA@=>49D=A81;B?D6>8>/CBEBC@E>;4??DCD>@9;?A;B9>@@6FF@BEBAD8DCA@?=?4>A>;AD=DFB??B7C@E@@77>@ABBB4>:6C=>6=A:AG?EC>E==A:BD6DDECDGEDDD?DBD<5=@95CB@8AADEG9@8/87=9C<@66ABB:>@FAC9EAEE>ECFA=>BCAA2@<<>4:A?>B@C>@<;E1>CBFA3BE4@B/EADD3@??0?;A?C1B=A>9D@A:8DC@=BE@C8=)==3@4;>4==68B+@D>??%B;?@@?A;DEBBE?DA=AC23<19C=CB@A?@DE:BEAC9C@@?:B@79:@?DC:@B>AA53A=@C=D>>ADA>;>4><4??A38?AA=E8>A@)ACA/>?=?C9=DE>9FE79>958B2E?B09;=C9EA889CAD?@8@>B:6@>6:29?-<69:<;9><>949=>D6>A8BDAD@872@;>:14'68F>A>4/=@?@;?@6;:>>:-BC@>AB3>CBEAB:<@<9EEBE?==AE;DD:BEEDABB@E6>>B?8A5=6DF@6@?7@AB49?F;B?BDBACDE@8F@A1@?;;<7;BF@CG?B@>EE2@AD=EAE42>?*GCC>B@;G7A43?/AADD;=>E7DCF8?A=3A@@>>>@+D<E2@CAA@C?A80<0>CAC<'AAEAADA>>B.DD9?<5=,7=DEE?E>:ACABEBEG;CFB@=DD@?E:@@B8?=-0?9>;/9=;3*>;6;;9842%21:669:=45-=;9'96.;:;?8;6>=>:==296<600:991?7545;<1=3<8:;79:=;.98<3<;;%0635<:/<:;3696/77.;<:::<;<;;:=>=76718+99?===:7;5>2==886>:1<07<9=:<><>9?<=:<8024=5=/0<;>=6=?=:-498<8?6<13>>:67:9<=:(884<=;;;?6=;;>;=9>><98/;7?>;88>6-;2:8:-46272:==::;37;7:=8>90+=?07;,547=;35<8558>:?;5;67687-<9::76>:?73<==<<<7<909?>;9>:559;=%%1585%>6<<9/<92;>>=0699>7:>6947+>9668<<5:=::7:5?77<:>=><=;=9>:78.7<48==6<%8<98(:?><>=2;==0>;:6 @rCer/366/24_4389_CCS ATGGGGCAGTGGTACATGGAGGACCTGGGCTGGCGGGCGTCCTTACTGCGCGGATCATGTTGCGGCTGAAGTCACGAACCGAGACCTAACTGGGTGTCCGACCTGCATACTGCAGTAGAAGACCTGGGTGACCATCAATACCCTGTGAATCGCGCACTCCTGAAACCATGCACGGAGACCTGGCTGGGTATCACTACCCTGCTTATTTTAATTGCCCTGCTGACAGCTGCGGAGGACCTTGGTGGGCATCAGTCCCCCGCGGATCATGGGGATGCTGAAGCTGCGCACTGAGACCTAGCTGTGTATCTCCCCTGCGGAAGGCTGCGGAGGACTTGGGTGGGCGTCGATACCCTGAGGATTGTGGCACTCCTTCCGCAGTCTGCTGCTCTAGGCTGTGGAGGACCCGGGTGGACGTCAATACCCTGAAGATGCGGTTACTCCTTCCGCAGTCCCCTGCTCTAGGCTGCGGAGGACCTGGGTGGGCGCCAATACCTGCAGATCGCGGGATGGCTGAAGCCGCGCGCTGAGACCTAGCTGGTATCTTCCCTGCGGAACGCTGCGGAAGACCTGGGTGAGCGTCAATACCCTGAGATTGTGGCACTTCTGCAGCAGCGCAGAGGACCTAGCTGGATGTCCTCCCCTGCAGAAGATGCGGAGGACCAGGGTGGCCGTCAGTACCCTGCGCGTCACGGGGATGCTGAAGGCCGAGCACTGAGACCTAGCTGGGTGTTCCTACCCTGTGGAAGCCTGCGGAGGACCCGGGCGGGCGTCAGTTACCCTGTGGATTGCGGCAGTCCTGCAGCTGTGCAGGGAACCTAAACTGGGTGTCTCCCTTGCAGAAGGCTGTGGGGGACCCGGCGGTGGTCAGTACCTGTAGACTGCGGCACTTCTGCACTTGCGCACTGAGACCTAGCTGTGTCTTCCCTCGGGACGACTGCGGGGATCTGGGGCGAACGTTGTTACTTGTGGATCCCGGGATACTGAAGCAGCTCACTGAGACCTAACTATGCGTCCTCCCTGTGGAAGGCTGCGGAGAAGCGGATGGGCGTCAGTAGCTTGTGCATTGCGGCACTCCTGCAGCTGCCCGCTAGAGACCTGATGTCTCCTCTGCGGAAGGCTGCGGAGAACTCTGGAGGGCGTCAGTAGCCTGCAGATTGCGGCACTACTGCAGCTGCGCAGACACCTCGCTGGGTGTCTCCGCTGCGCCATGCTGCGGTATACTGCGGCAGATTCCGGAGAGCGTCAGTACCCTGCGGATTGCGGCACTCCTGCAGCTGTGCAGAGACCTAGCTGGGTGTCTCCCCTGCCCAAGGCTGTGGAGGATCACGGAGGGCGTCAGTACCTTGCGGATTGCGGATTGCGGATTGCGGCACTCCTGCAGCTGCGCACTGAGACCTAGCTGAGTGTCTTACCCTGCGATGGCGATGGAGAACCCTGGTGGGCGTCTTTACCCTGTGAATGGCCTAGCGCTGCTGAAGCTCCGCACTGAGACCTAGCTAGGTGTCCTTCCCTGTGCACAGCTGCGGAGGATCTGGGCCGGTGTCGTTACTTTGTTGATCGCGGGAATGCTGCTGCTGCGCACTGAGACCTAAGCTGGGTGTTCTCCTCTATGAGCGGCTGCAGAGGATATGGGCGGGCGTCATCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCTTCCCCTGCGAAGGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCTGCTGCGCACTGAGACCTAGCTGCGTGTTCTCCTCTATGACGGCTGCAGAGGATATGGGCGGGCGTCAGCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCTTCCCCTGCGGAGGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCTGCTGCGCACTGAGACCTAGCTGCGTGTTCTCCTCTATGAGCGGCTGCAGAGGATATGGGCGGGCGTCAGCACTTTGTGGATCGCGGGATTGCTGCAGCTGCGCACTTAGACCTAGCTGGCGTCGTCCCCTGCGGAGGCTGCGGAGGACCAGGGTGGGCGCCATTACTTTGTGCATCGCAGGAATGCTGCAGCTGCGCACTTAGACCTAGCTGGTGTCTTCCTCTGCGGACGGCTGATAAGAGGATGAGGAGGGAGGAGCATCGTTACTTTGTGCATAGCGGGGATGCTGAAGCCATGCACTGAGACCTAACGGGTGTCCCCACCCAGTGGACGGCTGTGGAGAACCCGGGCGGCGTTATTATATTGCGGATGCTGGTGCTGTGGACGCTGTGCACTGAGACCGTAGCTGTCCTGCCCTGCGGATGGCAGCGAAAACCTGGGGGCGTTTTTAGCCTACGGATCGCCTGTGCTGTTGAAGCCGCGCTCAAAGACCTAGCTGAGTGTCCTCCCCTGCGGAAGCCTGCAGAGGACCTGGCGGACTCTTTACACTGTGGATTACGACGTTGCTGAAGCCGCGCACGGATACCTAGCTGGTGTGTTCCCTGTGGTAGACTACGGAGGATCTGGGTGGCTCTGGAGGTCGCAGGAATGCGAAGCCTCGCGCTGAGATCTAGCTGAGTGTCCTTCTCTGTGGATGGCTGTGGAGACCTGGGCGGGCTTTTTACCCCACTGATCTCAGCGCTGCTAAGCCCTGCACTGAGACCTAGCTGAGCGTTCCCTACCCTGCAGATAGCTGCCGAGGAGCCCGGCAGGCGCCCTTACCCTGCGGATTGCCTGGTGCTGCTGAAGCCGGCGCTGAGAGCTACCTGGGTGACACTACCCTGCAGTTGGCTGCGGAGGACCTGGTGAGCGTCTTTACCCTGCGGACTGCGACAAGGGTGCGATTGCATATGTTGGTGGGCATCTTTATCCTTCATACGGCGGCTATTCTGCAGCTGCTTATTGAAGACATGAGCTGGCATCTTCCCGTAGGACTGTGGCACGTCTGTAGCCACGCACCAAGGACCTGGGTAGGCGTCATGACCCTGGGAGCAGCGGCACAGCTGCGACTGCGTATGGAGGACCCAGGCAGGCTCCTTACTCTGTGGACTGCAGCGCGGCTGTGGTTGTGCACCAAGGACCCACCTAGATAGGCATTCTTATGAGACAGCAGTTCAGCGGCGACGACTGGGTACCAAGGACCGGCGCGATGTTCTTACCCTGTGGACTGAGGCACACCTGGGGCTGTGCACCCCAAGATCCAGCTGAGCATTCTTATCCTGTCACCTGTGGCACATCTGTGGCCAGGAGTTTTTATCCTGTGGACAGCAGCACAGCTGTGGCTGCACACTAGGGACCCAGTCGGGCGTTCTTACTTCGTAGACCGTGGCAGGGCGGTGGCGGGGCACCCACGATGCAGGCGAGTGTATTACCCTGCGAATGGCAACACAGGCTGCGCAGCCAGGACTCAGGCGGGAGTCCTTACTCTGGGGAGTGCTTACCCACGGACTGGGGCACAGCTATGGCTGGCACAAGAATCCAGGTGGGTGTTCTTACCCTGCAGACAGTGGCAGGGCTCTCATGGAGGGCTCGGGTGAGCGGTCTCCTCCTGTGGGTCGTGTTACTGTTGCGTCTGTGCACTCAGGACCTGGTGGTTGGGGTGTTCCTCTTCTGCTGATTGTGACACAGTGCCAGCTGCATGGAGGACCAGGGCGGATGTGTTTACTTTGTCAACTACAGCACTGCTGCAGCAGTGCACGAGAACCAACTGGAGCCGGATAGAGGAGGTCCCTTCCCTTCTGACTGCAAACAGCTCCACCTGCACCTTGAAGACCTGGTGAGCATCTTTGCCCTGCCCTGTGCCATTGTTCTGGCCATACACCAACCTGGACAGGTTTCACACCTCTATGCTGGATGGGCTGGCTCAGCTGATTGTGCACTGTGAGGTGCTGCAGGAGGGGCTTCAAGGACACATTCTTCTTGACTTCTCAGCATAGGAGTGTCTTACATCCAGTCCACGTCCCTGTCCTAGTCCTCTCTCTGCTCCTTCCACACTTCCTCACGGTGGTCTCCTGCACGCTCGTGGCTGTCAGTACCAGATGAGGGCAACTTCTGCATTTTCTCAATTTCAAGCACTCCTCTCCACTTACCTACCTAGTATCTCTACTGGGTGTCTTCCAGTCATCCTGCACTCAACGTGACTGATGGTTTACTCCCAACCTGCTCTGCAGTTTCCCTGACTTTGATGATGGCAACTTCATCCTTCCAGTTTGCTTAAGCAGATACCGTGGAGTCATTCTTTACATTCTGTTCAACTTCATACCTATTCCTCAAGAATTCTGTTTTCTCTATCTCTAAATGTGTTTAGAAG + 0*$,++.,*(0.0.11.,-0-21121&,*+.,1+'0,-11)-.2-.,,.,1,2&*--0.02.102***'/-11.11+,',)&*&*0.,1./$,+'$&$0-,%(*++00)(%**'/,--*,,-+/-)*')&+,'#*,**),)0,,1)++(&$,**---0+21*%)*+**&(&(()&*,+++1)0/+*(00,,1.'.1(.+-0/12,'-&%''%+.&.//).&-+1-+)&+.(+-,0110'+))&#%"&'+,,*-,-11.+0'&%0.-/'...00(1),'0+-.)--101-010.0.1011.1(0111.0-020--++102+0)+-/,,,,,,,((#&%*),++)(-.(.*%--%)%&+1-+),*10-11--)*&(,--'(,11/'/,000/*('*)*$*)--+(.+#&$'&*+,,%&,.(0-1-0*'0-'$-.)+$#'+)*1+.0201010'-&(-%(*,+0100*+/,.-(,,/21',(#%,.,,-/'--0%)(,(&)),*)'"&&'+$(,,+-/-(,*011,-//,)())+,')&'&(+(&,+++*-,))-,/111111.1.2/+/0102+.1-,.1/+(0,01..1+)%&$"%*+*1,./0,-*()*,'($*)'()##&')(**%&)*,,)"$*)**.1111/&).-/$&-,+'$)+).*$(&'*)'++**,*('()+&+-0,(($-,$'-*(&&''(*.$('&%")1,+.3/0.+01)-),*(&&+***/,.&#',-)*)/+'$+'$',/-%).%+)$($'%%))$'+)&#(,-2/(.10*40100#)-)3,.1+,2.3010+/14/,1%$+2+&.00/%*(,(&-))0*+1/-,),0*-.***&'),,+**'$,+(***..)-)0-%0*..44/.-05/,,/),/0,//0.&33,0-..10,)%)*./5114/21213(-*,3*1.)0)%%(1,"*$'//..#*()+++.+0((&,+--#%*'--.,'-/'$(-+.2-*&..,,)%(//11--)()/,'//*-01/--*/-$0001,*-)/-20/024333162#'.16$/17)-3:55)2736776668545'04203)2403/3-/2&0135'%31,340-,-%.//447.31552:.98:98746:9,3;9166276199068::4,68175:96-1/673+56799..2./4766666:82679/835:761694+83453:88::926.22696:7:.550*26400030*24/430782289.5)885,2)2680283556373755/9,14:575.97832481)65-460-4846559.97759&8-(6,99633359.6-46'7517.4:5244334036/822(12/898.77299:484376:2970432632993780344.849413011014:94.7944.432//32454//858:87245,9.894333'473.33'335/731101.8748064868:5444541:(125434549::419:856994672495714*8769032+032*.5614)3859.4'8426,61--,(-15300//2756932)3;97/42524411053003152,.00*52%3&*210634.4-'+310-23268:/74531,5:,1-593.:76)83,-5:80124,52.--1,/355,4114653.59945128/65335462(+-688-+:5547*6-7631793-7%+,.2,-463:5524'%-44,4:812064748177.%-1/,2695.347-678::..4.2+699:6::8/164.8:::98.-/9157:94/23/.%-+0573$$,+,381+)/.1/0854/110.-314834.333240&014'1-/,38851048672117334-,(2152-.22./37,8798:7,5/'52789:7:,75929212/1&/,.3..1.5482)8784255744.(10/03.%03/*+0/2,/424/079'1523/2-,02-053&26345143701-275:687:305531#0/()4833882/6/9-8371665&5:5/353097-065*501/)*+./,0.15'-/742,095:3343,45536:23/%0-/,..45366'/.',(0%++47(../3-3+34312066/2307532*,-)264).-/595750070/20,3/3/-0,,&',5+2-/%(/04/2262,+#(&)-+*((*0--4349/2&&0$157573'1.(+3242'5-59659962940**,'/%+.476641793-,0.33/+225923;771.8886875/0'/7334223%/2,-("(%,(-41+2&-4-.,02423530+,)25350314&/5-+,(0/**+03*/-/,,#)--/-'%(,-%%%'+%+)+-/*/1/+/-''&%$.(&-)2571289.1(702/'&,0504/0-5+0-.0/267583/-6.7658)0*1.*4(/1+,2%,24,134&(((,/.*335.35562/&-+(+.3/(+,1.-32.4*/,3.2/1+(.1-1050(05(1214:2/3/23787455:492/681437%6,..,/3.543952623424568483.44433/15416/884.+.)2,0.$*3466...&(3/-3.5896592433/709:734/.-300:'10/4'141211&..372-*3$20571202,142&2./62-23.0+.*)14:9776732343(59,6643360++22,-1115371,0-0+123699-3.5:79:234955822434770+:81343-3363)8+70-23+./-/1-1121256.41.0()$'///616/,1+10*/13.10/20234.314414*0,,0264/4+2/$-5,0'.20(34+/.,02422.'310)455650612664665121640+3642530*.+--*2.,2'11/-*2+054-+/0554224261-3502).+032//-343'&1154.2-'2((150)2'21//.%.'33410%.,/02-.34253141/3411645,31,325)5.5/.+4554*.-5/236410430)/02145*0364514/0.51/450211/.((04/640564*255,555233403331/.,25-36202104465/25.5165,42,15(/(02&10/+.4/103/$-22*1*)2*-+/%/666445*24156563565.44/&',00,1+4)0--2465045335(5146.436561/43256616015526.*55555323/10213'4.45+0.013-20/53551254.30/+/1)0025430/34/5-.,164644624,456134,4535-11/550'436641).+**3..2524-45/(540.5344661225525536140364*//0/60./1162555/4+*2/0536/4.64'2020435065-/.5651064'3.,$26533.65054144'0//24120-.25160-3--)14&4,)150213-.04.%244,%.03263'252.'5434(555035135/1/+251-11//)22'33350121../-/+55+3)061054551001++.2/(30+##)./-,.,-26*0+-5455512).,+,06+26655*5.-*004.1424011.,),123,/15--,1-32+2*.3-)3-1'32*-0+1251,.54/23254,2313//10+1.1(5....1/0404516/'--+354-663551.0331.44535.0/.4-2500325413*05665.441,-342455/#$306.5060-11)-.461+12)54)2*42.4(/421345&0#++)./263235211,0124'/.,)/2%2'.2215+21444*4./0165/-5326556.)40./5550,)--+3/4*20*5303260650425564663/0/+$+,,-1155//#-55610/5043.2443351/4041464033.4*-5655155.526-410./63034/340336515643164+*)'4100+.114446513045524%2*.1/,3445-26/%250-122/26665350-1-5356635-1//2+004643354.55625.34*/13634221.*0..-&210*4406444.3*35540456/452155563146136364)/54-02..6)'1120./-.133&120456345651415/466435043,45414525465+4366001+552631144./14636+66+23211233533365*26456515355+2.6-441%125633560*34,533646133/.*/153/60'#%**,,22551555563)./0/2363551+0536.3220.0344/4655214'$,/.-11,221,'01 @rCer/367/25_1817_CCS ATGGGGACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCAC + @C0DED?@C@CE@E==:C5CC=@GE(ADBC;C;C9DF?D;7CBFFGGECCCDBF@9E=BAAGF9<@@D@C2?>CGFCGEGEBCE<=86BE?C>?:7BBDEDE;C>;DF3-9A9;D3BFE=9C=;CD169>7::;087:<>=DDDF:CC7ACA>A&?CD@D@?@4A?EFGBCEIGHG?IHIGHF<9B@84DII6HGFE9ABBDDFCI6HDE6FGFJHFHJEHFIGAEGIKIIHEK@DBGGGJ@KHBIJ7JI??@EHGFEHI@EFEG>I=GG@IIFC5CBEHE?F9G?J8JEKIE;BGGJHEJHF7IKKICBI9?@=HJIJFGCHDCC:?=D6AEG=>GFEGJCED@FCGF6@FEH?BCFIH>EBE7@9=::?EEI??>DDHGEE7:A@CDH;KIKJ?E9GFJIIDD;AD>EGE:DCCGHFF=@6BGGIFC:HFJB:JHKBCJIEJIJ;IKKIGJKAKKKEFI=IGCKJJKJIKKHJKJGKJKGJBI?EEF>HG:HHAE@KIJHJJJKKKIJKKJHJGKHGKGJIKKIHDIKH0KJJIKKCKHJKKHKJIJKHKJGKKEJF>3AIGIJGKGKIKHIIJDKIJ7CCEH4IKCFBIIKKJKIJEIJJJICJGIIHJIKEKJJJJJKJGKK:JKKHKJHKKJCJIJBKGJEGFEHC@IDIHKJ@JDKKJFKHKKKJJKCKFJKFAKDDIFKIFKGI3@JIJ0JGKJKHJJKIKIJHKIIIJJDJJKDIEK?KJKIKKKKGKKJKIIJK=FHJFIJEICKKKJKKJJJKIJJJ23GKJIBKJKKJIGKKJIKHHK?EIIF?KKIHJHKF.@HJKKH@FJKJJJJCJKJKJHKHJEJJKJIKKJ;K9K?HKD?JK=EFDJIKHKJC5JK>KIBKJIHJJ5JJKJHKJEKKJKK@JIKAJJKJAK;EIIJKEKGGJ:KKEJJE8JEGDJICJJJKJJCFHJKGJEFBJKIKGJCFJ?JI;IG*H>EB@BB3< @rCer/368/1533_55_CCS GGGATCCAAACTTATTCGAAAAGCTAAAGAGGCACCATTCGTACCTATTGAATGGCAGGTTTTGCAGCAATTGTTGCATATGGATTATACAAACTGAAGAGCAGGGGAATACTAAATATCCCTTCATCTGATCCACATGCGTGTGGCAGCCCAAGGCTTTGTTGTAGGAGCAATGACTATTGGTATGGGCTATTTCATGTATCGGAATTCTGGGCAAACCTAAGCCTTAGAAGAAGAGATGCTGTCTTGTCTTGTTGGAGGAACTTGCTTTAGTTAGATGTCTCATTATTGAAGTTACCTATTATTGTTGAAAATAAACTAATTTGTATGGATTTAGATGGTAACATGGCATTTTGAATATTGGCTTCCTTTCTTACAGGCTTGATTTGCTGTGACCGAATTACTAGTGAAGTTTACTAACTAGGTCATTCAAGGAAGTCAAGTTAACTTAACCTGTCACCTAAATGTACTTGATAGTGTTGAAATGTCCACTTCTTAATTTTTAAGATGAACTTAGTTCTAAAGAAGATAACAGGCCAGTCCTGAAGGTACTCCCGTCCCAGTTTGCTGCAGAATCTCGTATTTTGGATGTTGTATAAGAGTCCTATTTGCCCCAGTTAATTCAACTTTTTTCTTTTTTTTCTTTTTTTTTTTTTTTTTGAGAAGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCGGTTCACGCCATTCTCCTGCTCAGCCTCCGAGTACTTGGGACTACAGGCGCCCACAACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGTTTCACCGTGGTCTCGATCTCCTGACCTTGTGATCCGCCGCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCGGCCAATTCAACTTTTTCTACCTATTTTATGGACTGTCTGCTCTGTTAGAACTCTGTCCAAAAAGTGCATGGAATATAATTTGTAAAGCTTCCCACAGCTGACAATATATGTGCATGTGTTTAAACCAAATCCAGAGCTTACAATAGAACTGCATAATAGTAGTATTTATTAAAGAATCACAATGTAAACATGAGAATAACTTAAGGATTCTAGTTTCGTTTTTTGTAATTGCAAATTATATTTTTGCTGCTGATATAATAATTTTAAATGTCATCTTGAAATAGAAATATGTATTTTAAGCACTCATGCAAAGGTAAATGAACACTTTTTAAACGTGTGTGTTGCTTATTTTTTCCATAAGAATTGTAAACATTGAACTGAACAAATTACCTGTAATGGATTTGATTAATGACTTATGAGCAAGCTGGTTGGCCAGACAGTATCCCAAACTTTTATGTATTACAGAAGGCTATTACACTTGTGAAATTCTCTTGTCTAATCTAAATTTACATTCATGGCGATAACATGGCATATGTATTGTTATTAAAGTAAGTGACCAT + +,)')-*($%))*,.)1/111+/+%',*0-0-0.0*$/)+//,*++)-)#.00+,1)*'200,.1+/-+).#',)+/11++)%#++)351/0---/.+53-441/(%/%0*5686+3)113&7-.75097439.888724/.02:27-/.3(8-1286:.44'/275798:0/2251..5-3%2:8;;36.868(23434-(22),+0.,/15'/33$''6:/3:13-..91$2+/*52),,**-%3*&+)-+/10/%,0*06.3-9744(*.61.-0712*+/45685(37528-84,84-*22123*3-01$,33'+5826:.68::97216&3/42-#*4+0-'0%.-/47&66+330571.0&7/70/.5-+,/4.04.8../&-%($*)-0)64)5%0*%&'*1$%*/.%-+*0..(/6375==2=9(;9@79=?C<:@;;(7<0A+><@::(:@.:;<.>>7;;//54:;2/2@2-15,38<4+0-8;973?07=?@-0)>986C;<9859?1/870&6<0,+5B9@6>9:58?:87==:'6->4,,40"#(;9&78>C<@?<:<=:40<372>0.20:)749<98/0761,19:57;1*2)0%,857&83,-7/<8+A4::BBA=-+BABC8@<;#;39;1;0@9975;48458;;8@><*21%;792-387<7<8:-*4348624;9.+5.0205555?8=;2<:,38//'<997:;A59=6969222%93/2<.21%:;09@8:,8:%65579;;'96?@3>=;-6.<:89:&:8:<<03<94/(53<8<<7%/>=68.6/5:<$9@-:%9::3@93761&3>?51:-<<68*:9.1'64.2+$&($0#,)1)20=+6;4686.-'082,+06168%1778<0.1,7:13+78937888+;6>;>><.=;>8-699972)#2%)0/4/67-)/::1.37079':=7=:3=<:-00801)0+/89:6;8653<=88(01/52/0)$.-/*7033.,/4+478476747464.::235.5728<4:7553596-'+-6:61274/77-.2(5<0616*90/555898,1236:<2(3/:77(<483&90/-65567%988<6424+/04*/3(+22#,5.6..14#3947<9/16848*13609<<9;-9(57765<698217/3.3::&88<-50.017/#31*5-%&,)(.5&2.-/275343/-&.-5062)3/34,3+333037.5677180/'2+-4,.*25225350.+-3527.11/01--/81857-7.,(%4%%%.&57452.,-$&/(2220245&54512/+22548562128:109565&).,/:/:9224:8245/-,+32:;4;;73+.(%$(,6-2)1.:2.584-5659:3598.&6512&)-&./)%-4.-.&35 @rCer/372/25_1821_CCS ATGGGGCAACGGCGGGCGCGGACGAGGAGGTTCCCGAAAGCCACGCGCAGCTGGAGCAGCGGCGACCGCAGCTGGAGGCCCGGAGCGCCTGCGGGGCCGGCAGAGGCGAGGGGGTTGCGGGTAGGAAGGGCGGGCTGCGCGCCCCGCCTGCGCCTGCGCGTCTCGGGCCGGCCATGCTCCCGACGGCTGCGGGATTCAGCATCTGGGGCCGGGTTGGGGCGGCGGGTCCAGGGCGCAGGTGGTGCGGCCGATGAGCCGGGCCGGAGGCTGAGGCCGCGCGACGGGGCTGGGACAGCGCTGGCATCTTCAGAGCAGGCCCGGGGCAGCAAGGGAGGCGCTGCGATGCCAGACGAAAATATCTTCCTGTTCGTGCCAACCTCATCGGTTATGCCCGGATTGTCTTCGCCATCATTTCTTTCTACTTCATGCCCTGCTGCCCCCTCACGGCCTCCTCCTTCTACCTGCTCAGCGGCCTGCTGGACGCTTTCGATGGACACGCTGCTCGCGCTCTTAATCAAGGAACCCGGTTTGGGCCATGCTGGACATGCTGACGGACCGCTGCTCCACCATGTGCCTGTTGGTCAACCTGGCCCTGCTGTACCCTCGAGCCACGCTGTTCTTCCAACTCAGCATGAGTTTGGATGTGGCCAGTCACTGGCTGCACCTCCACAGTTCTGTGGTCCGAGGCAGTGAGAGTCACAAGATGATCGACTTGTCCGGGAATCCAGTGCTTCGGATCTATTACACTCGAGGCCTGCTCTGTTCACCTTGTGTGCTGGGAATGAGCTCTTCTACTGCCTCCTCTACCTGTTCCATTTCTCTGAGGGACCTTTAGTTGGCTCCGTGGGACTGTTCCGGATGGGCCTCTGGGTCACTGCCCCCATTGCCTTGCTGAAGTCGCTCATCAGTGTCATCCACCTGATCACAGCTGCCCGCAACATGGCTGCCCTAGACGCAGCAGACCGCGCCAAGAAGAAGTGACGCAGGAGCCCGGGTCCTGGCTGCCCACCTACCCTGGGAGTCTTGCTGTGCCACACAGCTCCCCACCCGCTGCTAGGAGGTCCCAGTCTCACGCCTTCCTCATGTGTTGTTCTACCTGCTGGGATGGGGGTCAGCCTCTCTTTGGTGACGTCATGTTCTCTGGATCCAAGAACCCAGGCCTCAAATCAGGGAGGTTACGCGGGAGGCCCCATGCATACAGGCGGTGCTCCTGGGTGCCAGCACCGGGCAGTGTCATGCCCTGCTGGCTCAGCCCTGGGGTCCGAGATGCTAGGGACAGTTGAGTGAGGGAGATGGTGTGAGGGCCGCGTTTCCCGAAAGGCAGGGAGTCAGACCTCCGCCCCCAGCTAGAGCAAGTCTGGGGCACCGTGCCTGGGAGGGAAGAAGCCATCCACAGCCTTCCCCGTCGCCGGCTTCTCTGTCCTGCCTACCCTGGTCCTGGCGGGACTTCACTATTTGACTTGCTTTCTTTCAGATATTCTTGGTCAGGGCCTGGGTTGAGGGAGCTTAGGGAAGGACGTCCGTCTGGGTGCTTTTCCTCCAGTTTGCTGGCTGGCTCTCCGTCTATCCACAGTGACCTCACAGAGAGGCCCTCCTGCCTCCCACGCTCATGCAGTGTCCCCCACTTGTTTGATCTCACTGACCGTCTACATGTATTTATATTCTGTATTTTCTACCCTCACTGGAATGTAAACTCCATGAAGGCACAAACTTTTCTTGTTCCCTTCTGTATCCCTAGAATAAGACCAACCTGAACCTGGCATATAGTAGCTGCTTAATAAATATTCGTCTGTCAG + ?I4KIIJAEIBHC-DJGHJCK=JJB:IIHK6D8JJA)FAEK>@FEKK>G?BDHCGIKI-IH53K>EGKBCDKHAG(KKKI6EIJBKECFFKBJ@JKG-GHFCFHIIJ$BD@K;@$G81G=4?II;K?FGDK0KKJEJIFFK>IK1H7JC@JH;<;4D,@FB@JHGG,JIKHH1GD>F8CKDH9GKDGC@0IG@DCDF?6J1FB6@FKKHJJ/G-HIG9:74GHA<@=FIC5>B;@6AB?FFIF>BDFBKHHIKBH7K0JK3G.I2*KFDH7DCH>2KDG*GHH@5ICKEJFI;IE*J.KJ?IGEJG1$FF;FE4GDI;HGHJJ;I?2B6G5JJI:GCA:J>DK>JK8JDJGADH5HIH4FIE@2HCCGJHAKBHIKJG@3E7<<=@JHHKIG-IJ<+6FEBBH=EE9JF4;EB8DEJKIGIHDBCAJD$AJIG>G;KHIGGJDBEKB::J/J>:&78E6'DB7C@DGGD559HDEDA2G9I;4I81;IB:<8EB9C=GAKK8AK;JKD@-EDKCHEID<6KKEH=CBA4FCJDB;JKCKEGFDIGFIJIBC+BBIJHGIB8IFJGKEHEHCIIGGEFCFACIHJCB@B;KE@HIJIJC;JJIGHG2KKGC-K?;C2HAHB;EH@:BCAFJGFHHF8BKAHB4J>JHCGFGJCIHHHHJJAJF=&JK6>KIFKIAEEFG,KCA9CD@1JIF&KJEAH>EGIJ@IHIIKIFHDEHEG3EFHKI?IHEICG3H8/ID>(/FDJF28JHAD)CKJKAJEG>I4D8E,FJ=KIJIFAHJGB$EB:,F@KIFKJJKKDK1I>A1HJCF=)GHGGEEHFECCAKJCFJ7HHKDJJ<5GIJECJIDKCI9:1F9$;@AGHK=HHB6F%BA@EJHIHGE:DH-IEIKFHJ8KJFIGIIJJDFGB;JI0IBFH;JI'D:B7JJ5IIF&JIF???;BBHIJ4KF+JKKKGEF9GGKHF9CJIHH/JJKJF5D>F9DKF-IIG&HB5B*9IB9F@A=<;?63.@:D9FE>?;@C0?5DD2AFCA>:22E+@':2:2GC>AEC:CB>A=4EG><1==E>?E.DFF@?7D@D5B6%8?FEFC@<@+:=6@@=#0D(C>:D>=FFBFF>>CEBC>DC@:DF2;BFEF@B4B?B?>'A<E>;5:D=C=D?BB3CCC3ADEFEA5@A0EE&C?>??@C70=DF@<8=?*DDA=;A9DB.EF=@@CE;@B;AD:GE25=@/DB2?3(8:'&/;+?=>9C=$8<7=:8/7E7E<=A@GEC?,B?@>BG2GDF@.?FA:AACF;C@8B0CEAEF=D@1>AFEBC46;?7=9C?D?CIA@ @rCer/375/2678_62_CCS ATGGGGGGCGGAGTTGTGGGAGTGGAGGAGGAAGAGGCGGTGGGGAGTACGGGGGCTGGTCCCAGAAGATGGCGGAGGCGGGGGATTTCTGGTAGGTCCTACTTTAGGACAAGATGTGGTGGTACTGTTGAAGCGTCAGTCTTTGATTCACAGACACTTGAGCTTTTCAGCTGGGAAGCCTTTCCTTTTTTTTTTTTTTTTTTTTAACGGCTTACTGAACCTATGAAACCATGGCGGAAGGAGAGACAGAGTCACCTGGGCCCAAAAAATGTGGCCCATATATCTCATCTGTCACTAGCCAGAGTGTGAACTTGATGATTCGAGGAGTAGTGCTATTTTTTATTGGAGTATTTCTTGCATTGGTGTTAAACTTACTTCAGATTCAGAGAAATGTGACGCTCTTTCCACCTGATGTGATTGCAAGCATCTTTTCTTCTGCATGGTGGGTACCCCCATGCTGTGGCACGGCTTCAGCTGTGATTGGGTTATTATACCCCTGCATTGACAGACATCTAGGAGAACCACATAAATTTAAAAGAGAGTGGTCCAGTGTAATGCGGTGTGTAGCAGTCTTTGTTGGTATAAATCATGCCAGTGCTAAAGTGGATTTTGATAACAACATACAGTTGTCTCTCACACTGGCTGCACTATCCATTGGACTGTGGTGGACTTTTGATAGATCTAGAAGTGGTTTTGGCCTTGGAGTAGGAATCGCCTTCTTGGCAACCCTGGTCACTCAATTACTAGTATATAATGGTGTTTATCAATATACATCTCCAGATTTCCTCTATGTTCGTTCTTGGTTACCATGTATATTTTTTGCTGGAGGCATAACAATGGGAAACATTGGTCGACAACTGGCAATGTATGAATGTAAAGTTATCGCAGAAAAATCTCATCAGGAATGAAGAAGGCAAAACATATCTTTTGTACAAAAAAACAAGATGAAAAGGATGTGAAGTGGTAGATATACCAACAAAACTTCAGACTGTAAAATTGCCAGGATGCAGTTTTTCCCTTGATTGGCATGTGTGTATATATGGATAAATATACACATATACACACACATATTACTGCAATCTGTGATTGCTTCATCTGTAAATCAGTTGCAAACCTTTATGTATTTGACTTAAATAACTGTAAGATATATATGTACTACATTAAAAAGTGTTGATTAATAGATGAAATTTTTAAATTAATTTTTTAAAACATGCCACACATTGTTTCACAATGTTAACGTGCCAAAATATTGTTCCTGTCATGCAGAGTCTAAGAATGCTTTGAACAATTTGTAAACTTAGTGAAATAAAATAAGAAAGCCAAAAACAAACAAACAAAAAGCATATGGGGAGCTGGTATTTTCTCTTTAGCTTACTGTTGTGCCTTTTATTTTTCTAATCACAGCAGTATGAGTTATGAGTGCCCTAATTTGTGGTTAGTTTCTAATTTAATGCTGTTTCATAGAGTTTGGAATGTTTTGATACAGGGTGAGAATGGACTTCTGGTTTCAAAACCTGCATTACTGGAGACAGCCCAAAGAGTAATTTTCTGTTTTGACAGATCTTACTGGAAGTAATATGCTAAGCAAAAGAGGTTATCAGCATTAAATTGTTTTGGTTCTAAATTTGGAACACTATATATAATTAAAAGTAAGGACTACTAGAGGATTTAATTAGAATAAATACATGTTTTGGAAATACAGTGACCTCTTGCAGTGCCACAAAAGTGCAGAGTGGTATTAGCTGTCATCTGCAATACAGAATCTCATTGCTTTTGCACATGAAGCATATAGGAAACTCCAAACAGATCAAAATGAGGTTTCCAGTTCTGTTGGATTCTGTCATCTATTGGGTTCTATGAAGCAAACCACTGTAGCTTTAGCTGGGTTCGGTCATATGACTCACTGTTAGTGGAATGCCTAGTTTTTCATCTTATATGCAGTCTGGGGAGTAGATGGGTACATAATTTCTTATGTATTCGTGTGTCCATTAGTGAATAGTTCAAGTCTGTTTAAGAATGTTTTGAGATGGCATTCTCTGCATGTTAAAGATCTTAATGGCAACCAGCACCTCTTAAATATGGTTTAAACATATTCTTAGCTAAATTTTTTCCATTAGTTTTTGAAATTGATGGCAGTTGTCTGATCCACAAGGGCAAGATCTTCTGAGTACTCTGGAGTGTGTGTATGTGTGCATGCATGTGTGTGTTGGAGTGAGTGAGTGACAGAATGTGTCTGTGCATGTGCCCATGCTTTCCTAGAATGTCAAGTAGATATTTTTACATTTTGAGTTTTAAAACAATTGCTATCAGACTGAGATCTTGTATGCCAAACTTTAATCTGCTTTTATGTTTTCAGGCTGAAGGTGTGAAAATCCTAAGAGGATTTCATATTGAATATGTGTACACAATCTTAACTATTGTGGTGGAAAACATACTACTATAATTTATTATTATATCTTCCAGATAATGTTATTCATTTAGAACAAATAAGGTATATTTTTTAGAATCAACTTTGTAAGCACTATAAAATCTTTAATAAGTTATAAGATCTATGATGTGTTTACCTTAAAAATTGCTGTTGAAAGCAACATGTATTAAATACGTAATTATCATCTG + ;2<>DDD/CCAAA>4D9A@7;B5;38E9=<&>;EC9<@DCEBEGEGC5@AA=BBF1?:F:>@CC>@EDDGA=<>=A%CEA=DEEDC4;CA7AB8CA?6<=76@DB=C6EA>BFE=E@BB=?D,C@DDAEDC>A?;AB;FEFCFFE6C8?F>BG:EDBEDGE7@>AAA>BBBCB@@CCCCD?=A$;GGEE@:@CCDGDF@8>>B815DA:DAE@:E@>8@FBE@DCDD8B>?8E;EB@AA<.715BB@DAG7DE?F?DC:FB85@BA;;=;C*:C6G@FGDABG==D?@E=?.C>?BA5AC;8A=>CB;ACE;GB@BBAC>=4;E??>EA>DADD@EAB?1E>4EFE?AD@FFG@FFB4EGGF?DGBGDEE<='?4AEGD6EGEACD8CA;3>A2DGBFCFEBFCBFD=FDEE0@B==DE,BEF??/<8C=CA=BB@@?B;8AADCF<>=FGFDFD?EED6EEAEEC=6CF?EBECAA6:=:A79@DBFD>CD6EE>C7@;<7@/;=4:>A8CACFB>@D2@=F?DDBA)<@?A:4B49+63B=AB@>EC?ECEEDADFF3D:>CA>CBBD@'8@D@?<9CA>FF@FBGCEAB7E>=CE>C-BEA=C@D<>DBGFGCED;F?7D7<@>@F;E?C=78B2G;BDDA>@>@<FB6,7BBDF8D=FD==A>2CF67?C.EG4FFD:A9EGCEED:BBD:@B9FB>BA?ECGECBD=C>D@CC?=@DF@CB6?;6?>AC>BAA+B7=D<@FE?/?0:FEB:DAC'DBGGA?FAECBC?DGEDG=GE6E?A3D?F?A?CE?=ECC3BGB@BAF?=@ADFEE:DC?>EBB?ACEGEFD@?E;ED><8G:D9A?FEDDGCBDB>B1CDGE0D6DD/BBBAA?B:D:CA8CF1DB>@;A/@<>9;14>2;5B96EAC?A=95EE9+16$@ADDG?7C>C?D?CCD;C4ED@BCE8ECA?>CC;5AE%=@G?DF>D@CBC@>AFB;FC=@:9FBDC2AA>CD/BD?B<;DD47BBC4CA8D?>7;B8@AEG=DD<=EF?AA2C@EE5B>E6CEDA@>>A@)@CDCC8>FE-AEDEGCFDE@E?CA@@>7EDCF?9FC>F7=>=80AEC%0CAED/E>?9EA:DBGE@A?@7AAFFEGC=0C>9AE:>E8C@>97GDFBFFEE=FAE=GG@C.>@BB?D@7E??EFBCDA3EDE9F>FGE,CBFGDEA@76416@19C89?E.@?B>??+@@CC&5>3=FDDA=?=C8A??DEFFGAECABC>@FC8;E8+EI>BF?H58HG@IGFIFIFJDHHHHH2GBFD?AEE7?C?C%5A>D:=<-?5BBGBECFJFJGEDEB=I@EEHIIIAIHGC8BBIH;E;EHHGF8GHGEFF7A7FEAB=68@;<>CCDBAFED=CC?F@A;A>CA6ABGFGC>FDDFB?>C@4BEGED<6DHIC?F@>IDAHEBABF>HGEDA?=>7AA;DA:@(A7=E,@EHHG7IFHHEFADDF=E<=CB?5<@D=DDCA9E>=DBGH:H:DIHDJE?IE?IJAHBGCGEF?@A5D?D=9/<>8DHADH9?@AA>D+EEB=7ADBA@@,AFA;:6EB>ECECDE@?7B@GD@ECD?GBGH5FG8C6DDC?@;5@A;@ICHHJFCGBF?>A9AB?>7EAHIE;GAE?EGHHIHIGHCFDBDCGDFBD9BCEH>HCHIIJGHI@FJHEHEG>EFFGII*FIEGHG7HFDGGC%?GG.GHBG4C?=FFC:=FDFII@H7GE4GAE=EA?G@9EGG7I@;AIIDFJHA>ADGIHIA4H?DG3C@=>85BBHBHDEHBCJEIHGIDD?BCFE@8CH@IEJE=F=DHIIHHJJJJH:??D?FHIDBHD2DEHI4DGIH:D7EE6AGA=6?CC=>BE96@BB.??EDBFEBFF=BDE?FCBFBE@@7=EFC @rCer/376/2035_54_CCS ATGGGGCCCCCCTCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCTGGACGCAGCAAAGAGAGGAGAGGCATCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGCTGCCAGGACAGACGCCTGAGGCGGCCAAGATTCACTCTGTGGAGACACCGTATGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAATTCGGGGACATGCAGGAAATCATTCAGAACTTCGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCTTGCGTCCTACAGTACCTAAATTTTTCTACAGTAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGTCGAGATATGCTCTTAACCACCCGGACACAGTTGAAGGTCTTGTTCTCATCAACATTGATCCCAATGCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACGGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCTCAAGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCTGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACTGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACGGCCTCTCTAACCAGTGCAGCATCCATTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCTCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGACCCTTGTTGCCCTAGTGTGGGACCCAGCCCTCACCTCCCCCAGAACTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCAGAGTAAGCAAGGGAAAAAGGGCAGATCATGTGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTCTAACCTGTGATTCCCCCCAGCTCCTGAAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGGTGTTAAGGTGGAGAGGGCATGTATCCTCTGTCCTGATCTAGGTGTCTGTAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCATGGTGCCTCCATCAGACTCTCCCTACTTATCCCATATTTGCAAGGGGAGGGATTTGGGGCTGGGGCTCCATTTACCAAAGCTGATATGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACATGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGGGTGTAAAAAGGAAGTTGGAATGGGAATTGGTGGGCAATGAACAAGTGTCGGGGAAGGATTGGTGCTGGGGAAACAGGAAGGGGCCTGGGGCCATTTGGCTGCACTAACTTTGGTAGCTCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTACTTGGGGCTTGGCATAGAGATGGAAAGGGCTATCCTGGGCTCTGACCACACTGTATTATGTGTGGAGGGTGCCCTCCTGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGATGAATT + 6CDFB;AEAEE17DC.D>5>8FB>85E?C<@>:@@@B2D@=DA==GD:'8BCCECDB>/CCDFCB@EFF9<=:E9C?BD8?FFFF>CD?D@=B70C>9C:DDEB@EC>29FFE0FB6CG9AF2B@EG<9FA9F95@GABFD=EEFGF;DFE=9FG@CFF?C>A5A8A@D7DEEAEF=7ECF7E=@?;EGFC83@0>EE@?@?2B=<=BD@7DE@>?>9@.7;AGBE;@G@GCFGCC7=6GE=BFGGGC>CBEE6>C1BC4@E*A3;???7CAEE;CFD3ACEBBC7BADGBFEEE?DBBB;8?$552CEAD6@EDFF:6?CABE?CCDA3<;C6D4=?>4CA@E??E:BFF?@?=7B@8@EFCDFEC?:7BICII?F>FCE?C>H:EEEHGHI=HGGH?>CA5FH>CC$9?FE6A+C6@HIF;A*AI:F@>AC*GEHB@FHG@CJJ>EDFHCFGHCD@EBIJGIAHDFCF<9CCF>A=?@A@DE;IFHF=)I:>;E>CIF@EEBE@DE1BACA<4?@6DE7DIIIH:E<-<<2C8-A=@D=C6?958A;DIFGH>G4I@=FIIHECG?EDEB>EID?HC3KHJIDEEACK:DJKIIKK;G9E@=CHDHHAGFGA>FI7F,E6E6HDFDJEICJHD5DH8CB@GAGCD27=8C;E?BHGJIK@KH?EI7FGGGCJDEAFIHJ?HDFFKHI@JJIJJJ>GIDIK>IKIBG>JIFKCHBKIKEJGIDH?8FA2@GEJF=@HI=H9=CDGI?IGEGC@JIJGHHFIFFFE:(ECAH9GGEDD?JHHJAIBH=6JJEG=>;>CEDCGD6BIE?BGGHHIIHDEE?G>A>H;JIGEHHI4@H@@D=%=@@$7CB9E6GIGHHEG@CEB>@;B=EHF4@E+EIGIJ>F/EGDHIB:3=BF?BJFBEGD<6FCE2GHH?GCDFI0IJII@HEF@5GIJ7IIJEHJFIHGDBE8=8ABGG6CDJDGGGF?;:>F7E?FA9DFHCB=GDF=E@?HHF=;EDDD&DIBEIEIIGIEHHEDEHFGCA?AB83>;BDB8GJEDFGHIGF=F>BHA5G3GABCDDF?IGIIAGEJ?HIAIGICEBHG8GEIIIDHG@G7JF@GJCEJHGEHEHHIGFFHI2IHIIGIAI=-5AHIHAH5DDEHHADGDF?IFFIGHI;HIHFEFJE@JFIGEFIC:HDIEGG>AH*CADFIJD?56BFDE?IDAJ>CIJ:E>IFI@GDF:>?1IH@DCIHCCBAFF3HHCF>6F@9BDG@B64>2I=CEDBFFH7HE9HFGAD;AFB5G9HHCCIHBE9@@DA6A>&@>IIIHJB3B7BGG?F@AE:B;HIGHGC?E@D9=HCEEEDGI @rCer/377/25_1931_CCS ATGGGGGCTGCCAATACAGCTGTCATGGCGTCCGAGGCGCTGGCTGCGGAGAACTGGCCGCGGTCTCCATAGAGCTGGGGGCGGGCGGCCCGGTATGGAGAGCAGCCCCGAGAGCCTGCAGCCGCTAGAACACGGGGTGGCGGCCGGGCCAGCGTCAGGGACAGGTTCTTCGCAGGAAGGGCTACAAGAGACCAGGCTTGCCGCTGGTGATGGTCCTGGGGTATGGGCGGCGGAGAGCAGCGCGGGAATGGGCTGGGGGCGGCGGCCGCCAGCAGGAGCCTCCCGGACTCGGCTTCTCCCGCGGGCTCTCCTGAGGTTCCCGGACCTTGCAGCTCCTCCCCGGGTTTGGAGTTGAAGGATAGTGGTGTGGAGAGTCCTGCTGCCGCGAGGCGCCTCTGAGAGGGCAGTACAAGGTGACCGCCTCCCGGAGACAGCCGTGGCCGGAGTGGGTCATGAGTTGGGTCCCGCCGGAGACGCGGGAGACCGCCCGGATCTCGCCGGCACCTGCCAAGCAGAGCTGACGGCCGCCGGCTCCGAAGAGCCCAGCAGCGCCGGCGGCCTCAGCAGCAGTTGCAGCGACCCGACCCCTCCTGGGGAATCGCCGAGCCTGGACTCTCTGGAGTCGTTCTCTAACCTGCATTCTTTTCCCAGTAGCTGCGAGTTCAATAGTGAGGAGGGAGCGGAGAACAGGGTCCCTGAGGAGGAGGAGGGCGCGGCGGTGTTGCCCGGGGCTGTTCCTCTGTGCAAGGGGGAGGAGGAGGAGGAGGAGACCGCTCAGGTGCTGGCGGCCTCCAAGGAACGCTTCCCGGGACAGTCTGTATATCACATCAAGTGGATCCAGTGGAAGGAAGAGAACACACCCATCATCACCCAGAATGAGAACGGACCCTGCCCCTTGCTGGCCATCCTCAATGTTTTGCTCCTGGCCTGGAAGGTGAAACTTCCACCGATGATGGAAATCATAACTGCTGAGCAGCTGATGGAATATTTAGGAGATTACATGCTTGATTGCAAAGCCAAAAGAAATTTCAGAAATTCAACGTTTAAATTATGAACAGAATATGAGTGATGCCATGGCAATTCTGCACAAACTACAGACAGGCCTGGATGTAAATGTAAGATTCACTGGTGTTCGAGTGTTTGAATATACACCAGAATGCATAGTATTTGATCTTCCTTGATATTCCTTTGTACCATGGGTGGTTAGTAGACCCTCAGATTGATGACATCGTAAAAGCTGTTGGTAACTGCAGCTACAACCAACTAGTGGAGAAGATCATCTCTTGTAAACAGTCAGACAATAGTGAGCTGGTTAGTGAAGGCTTTGTAGCTGAGCAGTTTCTAAATAACACAGCCACTCCAACTGACATACCATGGATTATGTGAACTAACTTCAACGGTTCAGGAAGGAGAACTTTGTGTGTTCTTTCGGAATAATCATTTTAGCACCATGACCAAATACAAGGGTCAAACTGTATTTGTTGGTAACGGACCAGGGGTTTCTTACTGAAGAAAAAGTTGTTTGGGAAAGCCTACACAACGTAGATGGTGATGGAAATTTCTGTGACTCAGAATTTCGTCTTCGGCCTCCTTCAGATCCTGAAACTGTATACAAAAGGACAACAAGATCAGATAGATCAGGATTATCTTATGGCATTATCTCTACAACAAGAACAGCAGAGCCAAGAGATCAATTGGGAACAAATCCCAGAAGGAATCATTGATTTGGAACTAGCAAAGAAACTCCAAGAGGAAGAGGACAGACGGGCTTCTCATACTATCAGGAACAGGAACAAGCAGCAGCTGCTGCTGCTGCTGCTTCTACACAGGCTCAGGGCCAGCCAGCACAAGCCTCTCCATCAAGTGGAAGACAATCTGGGAATAGTGAACGTAAACGGAAGAACCG 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20,5546524(2.3/05.0425524*324./&/36331.*.+.*050-/00.5--365533-/,./,5*3226462$0--%&$-0,*1,4516452+//-/-1,/.1)2-,2/5461/*/42456403-3442-0))1-2,+.&'*,/225*4135+*24221++*0-'--2.155433230/1',5+232/43-0/$21,241105$2-*22/020,321+--/664.5.14.465140*%%)*/-54266-1%211/3255+2**-26055/3654563.66/655.3/65,4,*).0*0'132./111//%-03504416304*.$215321351656064+54*2'2261061/2636314244554314*361261*/50$0-.4*0)-4/34511/04(230',.$1665504./3-$12.1+1/00/36641206-4000445255*,0/41(.1)&1../116452)21&-+(%%&-4.4411+13141+0-450,1,2264542322030.(2/6.51.015405561655303520142-*16215+-)-)+.31/2240.452303/*(0653.424-.2.+34524.25550.*02356*-04+,(06.21'/,1*.0/-5*.0),+3/4(1.1.5/05./-0151344.0(+0401344255/61503.'+'%113//3.(40%+('(),0+0/4,41231))-,1304664560665420-0463+56144,2%222*.(2223305026000101.50500**,.)/4045*3*311236+54355326(1.*+00*0*410'/12.32,/434/545)//'-6.1*0602/201445.53303056414*3212/45/04.435240/54*,,.4-642.325.*0.2..+2351024)4154/4/60,211634*52214121113/6124022,35+4305311+1656633/-/042140..*3-4/.+//1160'/'01-1104(-,/&.3.1461'5+4532'44066112&02)..-530-35251/302403/24/32+10+4-0522.2-/141,-/)00$+,004045264623,*,+2310531)*/2*1216+3.20420./*)'1..2-441+1/-0.02,/.15/+'**214+(010//135++12$'+1.0.0)/,5*/'1*)10+.%*''&-)./3524+0666421111'/-2022++-0,6644445)31:5+.1735050)13,,-0$.-%/)+'.-(*/)'').,+,%,-**.-,//*/110,,((+*+,*)''(+(++.,+,)+',*(**+,**001000*/(-)&%&++.+-,)+*&)(*'+$&(,*)**&'%$$*%*&')',(#&+*.2(&,+0),0&/-,((1--0--0,(-(&+,-2*).,0/)/-,1-,-0*++.0..))00,'&(-,,,/,+,-,00*+*,,'--,*%,//,++/'/*)&%&-1.---2-)-0)01.'//.-,/10...0(0/11,,0/).0.01'/-,)-0.+.+#+-.,0++/'-)+*)+1,0,-..--,-)(-+&/0)-).-*,(+(*1.0)-,*+00111,'))(-+.2+(-'('%+##$#%+)&)+*((***&&&*&)%(*',,-,((((())-*+.+*),,-&-*)*.,-+)/-00,+*.//*/*1121)0,),+212.,2,0-100/',,/0)010*1011,-/*%0/*1/2/1001-22.'.///-2021-,.,1-102/-%*00*+0-+00+)'/1.,(,,000/2,0/2111,1,*,)-,01)/0-,,11110/011,00*-,)'/.+0/(*%,+*10-)').-/-.2.,.0%*'..0112/11112-/0'100/&.,)-/)/./-00-1-020.2,+$*+,1. @rCer/380/1936_60_CCS ATGGGGTCGCCGCCGCCCGAGCGCAGCCGAGCGCACGCCGAGCCCGTCCGCCGCCGCCATGGCCACCACGGTGACCTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATTGGCAAGGGGGCTTTCTCTGTGGTCCGACGCTGTGTCAAGCTCTGCACCGGCCATGAGTATGCAGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGTTGGAGAGAGAGGCTCGGATCTGCCGCCTTCTGAAGCATTCCAATATCGTGCGTCTCCACGACAGCATCTCCGAGGAGGGCTTCCACTACCTGGTCTTCGATTCTGGTCACTGGTGGGGAGCTCTTGAAGACATTGTGGCGAGAGAATACTACAGCGAGGCTGATGCCAGTCACTGCATCCAGCAGATCCTGGAGGCCGTTCTCCATTGTCACCAAATGGGGGTCGTCCACAGAGACCTCAAGCCGGAGAACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCAGTGAAGCTGGCAGACTTCGGCCTGGCTATCGAGGTGCAGGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACACCAGGCTACCTGTCCCCTGAGGTCCTTCGCAAAGAGGCGTATGGCAAGCCCGTGGACATCTGGGCATGTGGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCACAAGCTGTACCAGCAGATCAAGGCCGGCGCCTACGACTTCCCGTCCCCCGAATGGACACTGTCACTCCTGAAGCCAAAAACCTAATCAACCAGATGCTGACCATCAACCCTGCCAAGCGCATCACAGCCCATGAGGCCCTGAAGCATCCGTGGGTCTGCCAACGTTCCACGGTAGCCTCCATGATGCACAGACAGGAGACTGTGGAGTGTCTGAAAAAGTTCAATGCCAGGAGAAAGCTCAAGGGAGCCATCCTCACCACCATGCTGGCCACACGGAATTTCTCAGTGGGCAGACAGACCACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCACCACCATGGGGCTGGTGGAACAAGCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTCAAGCCCCAGACGAATAGCACCAAAAACAGTGCAGCCGCCACCAGCCCCAAAGGGACGCTTCCTCCTGCCGCCCTGGAGCCTCAAACCACCGTCATCCATAACCCAGTGGACGGGATTAAGGAGTCTTCTGACAGTGCCAACACCACCATAGAGGATGAAGACGCTAAAGCCCGGAAGCAGGAGATCATTAAGACCACGGAGCAGCTCATCGAGGCTGTCAACAACGGTGACTTTGAGGCCTACGCGAAAATCTGTGACCCAGGGCTGACCTCATTTGAGCCTGAAGCACTGGCAACCTGGTTGAAGGGATGGACTTCCACAGATTCTACTTCGAGAACCTGCTGGCCAAGAACAGCAAGCCGATCCACACGACCATCCTGAAACCCGCACGTGCACGTCATCGGAGAGGACGCCGCCTGCATTGCTTACATCCGGCTCACGCAGTACATTGACGGGCAGGGCCGGCCCCGCACCAGCCAGTCTGAGGAGACCCGTGTGTGGCACCGCCGCGACGGCAAGTGGCAGAACGTGCACTTCCACTGCTCGGGCGCGCCTGTGGCCCCGCTGCAGTGAAGAGCTGCGCCCTGGTTTCGCCGGACAGAGTTGGTGTTTGGAGCCCGACTGCCCTCGGCACACGGCCTGCCTGTCGCATGTTTGTGTCTGCCTCGTTCCCTCCCCTGGTGCCTGTGTCTGCAGAAAAACAAGACCAGATGTGATTTGTTTAAAAACAAAACAAAACAAAAAACAAGATGACGACGACAAC + 3/989+>?>=99;<:65,;>=:;625?:;9;3:33=7:7;:7:3575=<=<::8.-+.8>?8;99645988/9818:37<5276=499=:7464/69?88<=:89<:=:;2=839297;5266749/=7>88;3;493426.3/;:14=>=9<<564118:8852<2>>?964/=468/6<<8=479<802-<730$*82:2;85:5=<455959:<=9797>;1198=:;7>9=47758;870679/:7=*71*<7:513<48>955846<4+&05767=856=5:475/,59>9:%5234=:68;:1=544163/8*48841;<>=85>47152//=3460.4-166//6/0:=1>4<<9;=<>9:<907=??;2<;473+1:2)8=61708>88?9;2465073859=9<9=8--98874;:6578,9><28649>>6>=4:>>93=<957945<282390889;>;8?:;4778<<712::9<89<-;3/>9==4;?;=::763>:-29/=87=9:;/94895;>:16<9?:5>78*5;6::1=7=(>9=$;<0<<999;*:;?:?B=:=B>?2=;7;399<01576A9<=@,9:;<:77998=6:81;@<8:%264(=;;>9>,;/99=1:>7;984>8;=8>=6>C5C><5=9=:=->3;9@<;=@>@;?9=?8;2-=;<$=<<6='9948:=:=:>=?79;=.=7:9;79(168A;?B?0B8<;A@@B@?:>8889@8<@/8A?3;7=2@A@@0(3;?:7/,.20C>-?@9;>A>>A?C>9@75'7;663=A?=?:;A59:?B=BAB96668?26;<8@A6:B:,=98?>4=:526=>5==>5>5:;;7==39<8998968/>299496;5<1<669@<;3;9.9/=A<<>?.=<39=>;?C>;?8=966(68?43=@>B=>?B@>;A<7?5:,:<1><6>>;<;8'>9>9?AA:7?8?A76>>B5@84=;A?@88936)8;;4'=:9BB7;0A>?C57==>ACA>3C==@A)?;89B?@=A:8@;<,<@:9<9579@7@;@?;?6?=/?>B8=B@:C:<>?A@9@@;'85169<;A9@8998<;;41>/<@A6@>:B==:6780:BB:;:3?<:>5:1>?<2:6>?@>;AA6;9<8=:38:9676-8365=9;<0=?6;252.<:730:<:69$50,539<;6.-0,54327>5379/:899:1+71739;/8987=<4:5:39;:&9/9:1:(<;><:6;=;:64?.==::2==8:896)5>>:;>><89:64/5766&3>:;5;/?5;26/:<4<=<;693<;9>5=:>:;4=6868<;.:;?;8>::99573;9:46/9?<:8:.=9<84978;=.>;4<::=7;33+4;0<56=>6;89,:9=7:7:=;898;;::;>?>=;9953;9/+319360:49;)203,858:135957241<<:;;706)45479,6:;>==;=9<5550863;4=797:>:3.%473<>9.288/;>5>=9.<59:;39489;:4822<*7=<7823>71<8;7;7)19::/987<9711:894725277::>;1::3.94K8KKKKIKK;B1KKKIIEKJK:IKJGGFKKKK'KK-JJKKJJIKKKJHKHKKJKG/H2B4JHJKGKKKKKKKKJKKJKHKJ3KKKKKIJFJKJIKAKKKGFDKKKKDC4KIKIKEKKKKA2C-IKKKKKH@JKKJHKI2KJKIJJKGEHK/I>KKKKJKIKK7KKKKKKIKHKKKKKKKKKK>KKKKKKKKKKKK:KKKKGKKKKKKKIKKKIKKKKKKKKKKKKKKKKFEJKKKKFKKKIKKKKKK;KKKKKKKKJKK@KJKKEKKKKKKBKKKKGKKKKKKKGJHJIKKKKKKK6KKKKKKGKJKHK0KKFIIKJKKKJKJKKKKKKKKKKBKKKKKKJKKHKKJKKKKKHAJJKKJKKKKKKKEKKKKIKKKHKFKKJKJKKDHJKJKCKEKGJID>K?G;<@KJD;JKKJJDIAF;KJKKGDKK9KKKKIJKKKKKK/KKKEJKKKKKIH9KCKKKKGKIKKKGKKKKKKJKJKJHEIFF+KK0KKIJKEKKK:JKIKKKKGJJKHKKKKKJKKH.KIJK@BG-IK5J7KK@KAKI<2KKKKJH>HA.IJKFK:@KJKJIKKKKKKKKKKKKKKJKDKKKK;KKKJKJKKKFKKKKDKKKKJKK4K5KKJKKKKKKKKKKK?KJKJKKK?KKFKGKHJKKJKKJHJJJIKKB.KKKKGJ;KKKKKBBGK'JKK2;KJKFKKKGKEKKKKIKK=9@KJIE;KK*KIKJKKKKKAKJKJKKKKKKCKJKKKKKKGKKKKJKKKAKKKKKKKK@KKKCDK.KKIKKKKKIIKKIKK=K;KKKKK>KJKKKKKKK0JJDKKKAKAKKI=HKKG=JJK;KKKKKKJ@EJKKKKKJJK7J?IKGDKK6KKKJKKKKKKKKFKJKH>DGKKJHJIIGJKKKKKJI7KIEKJIKKJJ>E@KKAHKKJIKIKKKIJIKKKAKKFJKKIK;KKKKKKKCCKKKAKKAEKKJJCJKKKKC6>GJKKK9>=I7@IKCF<8KKGGKKE.KKJHKJKJ7KKBKKKKK@EKKJKBJJ9FIIKDKKKIG@KKKKKKKEFF7BJJKHJKEKIFK*IIJHCDKGJHKKKDKKKKKKKKKKKKKKKICE2KIJKJJKKKKKKJKKJKKKKKK1KKKKEJHJEKKJFKKJKKJKKJKIKJKKKJKKKKIKKJKJKKKJKKEKKKKK+KKKIKKKKKJJKGKKKKKKKIJKDJK@HHJCKKKKKKKKKKDKKKIJKJKKKKJKKKKFKKKKKKKK:KKHKJKKKIIKKKKKJKJKKKKKJKKKKKKKKKKKKKKK>KKKKKKJJKKHKKKKKIKKKKKKKKKKKKKKKKKKJKKKJKKKKKKKKKJKKKJIKKKKKFKKKJKKKHKKKKIKKKKKKKKKKKKKKKGKKKKFKKKKIKKKKKGKKKKJKKKKJJJIBKKKKKKKK?KKKKKKKKKKKKIKKKJKJKKK3KKKKKKKKKKCKFKKKJIKHKJKKJHKHKKKKJKHKKKKFKK>IK2KKKKKKFKKJKKKEKAJKKGJKKKK)D43KKKK0KKEJK;=JKKHJKKIJIKKKKKJ:EIIKKGJJIK7KKKFKKKKIEKJDKKCIKKKKKKKKHJKKKKJKKKCHFJDAKAKKKDKKKJKKKKKK>GHFKHHKKKKGKKKKKIJKI;AJKKCKJDKD2EJD2@KKJKKKKJKKKKKKHHJKGKKK@IKKJKKJ@KBBDKJKAEKKKKKGG3KIKKKKKKHHKAKK5KKFKIBJJHKK=KKIJJK>KKKKKKKDKJJJIKKIJJKKKKKKKJKKKEKFKK(KKKJFKHDKCKK5JKEJKKKKKKK@7K;KFJKKDKKJ@KHKKKKKFKJKKKKKKKKCJE=EKKKKKKK0KGKGKJKKKHDIKKKHKKKKKK*KKJK5KKKKKKKKKGKKKKFKKKFCKKKKKKKKKKDKKKKKKKIKKIKKKHKKKKKKKHKKJKKKKKKIKKK?KHJKHKKJKKKKKKCKJKKKKKKKKKKK1JKIIKKKKJKKKKJHKKKJKJJ=KKKKKKKKFKJKKKKKKKIKKKJKKKHKKKKKCKHGJKIHKDKKK@KKKEKKKCEKKKKKKKKIKKKKJKKJKKKKKJ>KJIKK0KGKKKAKKKKKKKKKJKK?KKKKKKKIDIKK>KKCKKKKJIKKKEKKKKKKKKKJKKIKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKFKJKKBKKKKKEKKEKKKKJGKKKKKKKKDKKKKKFKKKKKKKKKKJKKKKKKKKKEKJGDKKKKKKJKKKKKKKKJKKKKKKKKJKKKIKKKKKKKKKJKJKJKKKKKKKKKJJKKGKKHKKJKKKKKKKKKK:KKKKEKKKKKKKKKKK>JKKIKKKKKKKKKKKJKKKKKKKKJKKKKJIKK5KKJKKKKKKKKKKKKAKJHKKIJKKHKGKKKK6JCKIJKIKFKKKKKJKKKKDIKKKK @rCer/390/3334_51_CCS ATGGGGAGGAGGGGCGCGGGGAGAGCTGAGCCTGCTGGGAGGCGGCGGCGCAGTGGAGAGAGCGGGAGAGCGAGGAAGGCAGAAGGAGGCAGCCGAAGGCCGAGCTGGGTGGCTGGACCGGGTGCTGGCTGTGCCGCGCTGCTTTCGGCTCCCACGCCTCTCCCATGCGCTGAGGGCGCCCGGCTGGGCCGGGCCGGCGGCGGGAGGGGGCTCCTCTCATGGTCCAGAAGCCGGCATGTCCGGGCCCTTACCACCCTCCAGGAGATCCCATGGAGTCTTCGACCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCGGATGGAGCACGTCCTCAGATACCACATCAACAGCTTTGTCGCCAGGGCTCAGCGGAGTCCTACACAGCCGTCCATCGACTCTGATGTATCTCTGGAGGAGACGGGAAGCCTTAAGGAAAGAAGCAGAGCGCCAGGCATTAGCACAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCCGTGCGGACAAATGTGGCTACAATCCGTCTCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATTACCTTTGAGCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGCTGTGAGGTTGGCTTCATTCCCGCCCGTCAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGCTCAGCTCCAGCAAATCAGGCGATAACTCAGTTCCAGTCTGGAGATGTGGTGACTGGCACCCGCGCCCCACACCCCTGCCAGTGCCAAACAGAAGCAGAAGTCGACAGAGCATGTGCCCCCCTATGACGTGGTGCCTTCCATGAGGCCATCATCCTGGTGGGACCGTCGCTCAAGGGCTACGAGGTTACAGACATGATGCAGAAAGCTTTATTTGACTTCTTGAAGCATCGGTTGATGGCAGGATCTCCATCACTCGTGTGACGGCAGACATTTCTCTGGCTAAGCGCTCAGTTCTCAACAACCCCAGCAAACACATCATCATTGAGCGCTCCAACACACGCTCCAGCTTGGCTGAGGTGCAGAGTGAAATCGAGCGAATCTTCGAGCTGGCCCGGACCCTTCAGTTGGTTGCTGGATGCTGACACCATCAATCACCCAGCCCAGCTGTCCAAGACCTCGCTGGCCCCATCATTGTTTACATCAAGATCACCTCTCCCAAGGTACTTCAGAGCTCATCAAGTCCGAGGAAAGTCTCAGTCCAAACACCTCAACGTCCAAATAGCGCCTCGGAAAAGCTGGCACAGTGCCCACCTGAAATGTTTGACATCATCCTGGACGAGAACCAATTGGAGATGCTGCGAGCACCTGGCAGAGTACTTGAAGCCTATTGGAAGGCCACACATCCGCCCAGCAGCACGCCACCCAATCCGCTGCTGAACCGCACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCTGTCTCCAACCTCCAGGGACCCTACCTTGCTTCTGGGACCAGCCGCTGAACGGGCCACCGGGAGCACGCCAGCGTGCACGAGTACCCAGGGGAGCTGGGCCAGCCCCAGGCCTTTACCCAGCAGCCACCCACCAGGCCGGGCAGGCACGCTACGGCACTGTCCGCCAAGACACTTTTGATGCCGACACCCCGCAGCCGAAACTCTGCCTACACGGAGCTGGAGACTCATGTGTGACATGGAGACTGACCCTCAGAGGGCCAGGGCTTGGAGACCTGCAGGGGGTGGCACCCCCCAGCCCGACAGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGACTGACCGACACCGGAACCGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGGTCCAGTTTTGGGGCGCAACAAGAACGAGCTGGAGGGCTGGGACGAGGCGTCTACATCCGCTGAGAGGCAGGGGCCACCGGCGGAGGAAGGGCTCTGAGCCCAGGGAGGGAGGGAGGGAGCGAGGGCTCACACCCAACATGTATTCGCCTCCAGGGGCGCTGTCTCCCGCTTTCAGATGCCTTTGCTCAAAGCTTGGGTTTATCGGCGTTATCATCCCAGCTCCGGGAGGCCCTTAAGCCCCAGCTGTCGGTTTTTACCTGCCTGTTGCAGATGGATGGGGATACCCACTTTTCTGAAGTGTCCCTTTCTCCATCTTAAGGGCTCTCCTCCCTCGCCCTCCTAGAGAAAAGGTGCACTTCCTTCACTCTTTCTACTCGGGGCCCTAAGTGACGGTCCTAAGTGGGAGGCTCTCCTTCTCCCAAGCTGCAGTACTGGGGAAGGGCTGGCACTTTTCCTGGAAAGGGAGCCACAGATTCTTTCCCATGGGGCTCTTCCCAGACCCAGATCCGGGTCCCTCACCCTGCCTGCCCTTCCTCCAGCTTCCTGGCAGCATCGTCTGTCGGTGAAAGCTACAGCATGGACACCCATGGGGAGCTTGTCTCTGGGAGGGTTCTGGGTGGAAGCCGGCAGGCATACAAAACCCTCTACCCTCCGTGGCCATGCAACGTCCAGGCCAGAACCCTGAAGAATGAGCAGCTGAGGCGCTGCTCCCCTCCCCACCTCCATACCTCAGCCTTGCCTACCCTAGGAATGAGCTTGGCCTCAACATCCTTGCCTGCTGCATTAGAAGAGGGGCCCTCTTCTGCATCTGAGCCCCCATCCTGTGCCACCTGGTGTGGAGCCCATGGAACACTCTGGTCCGCCTCATTTTAAACCAAAAACTGCTCCTTCACCCTCACCTGAGGCCCCAGGGAGAGGACCCATGGGTTGGTGCCAGGGGTTGCCTTGGGACCTCGGATCTCCTCTGGGGGCTTGGCTGCTGCTGTTGCTGCTCTGTACTTGCCTCTCGTGATTCTGTTTGTTACCCATGTTCACTTCCCCAGGAGACCCCTCTCCCCTGGGGCATCCTCTGCTTGGAATCCCTGTAGCCCAGCAGCCCTGCCCCTCCCAGCATCCCAGCTGGGCCAGAGAGAGCCAACTGTGCCAACAAGGACTGGGCCTGCCGGCTGCCCGCCTCAGGGATGGCACCTCATGCCTGTCTCGCACCTCCTGTGCCAATGTCCTACACTCCACCTGGGGTGGGGTGCAGCTTCCACTTACTGATTAGAAGACACCACTGCCCACCCTTTCCCCCTCCCTGTCTGGTGTCCTGTGCCCCATCTGTCTGTCTATATTTGTCTGTACTCCCCTAGGAGAAGTATTTTGCCATATATAAAACCACTGTCCTGTC + :6584',9'-333$68556/(5.#$.29.36,4:6488-2-*84*44+,$1887;743/56(.52'').,02:;0-+8084&887)26,68:8-6925-;461&1/::.:96959.50#::3495,7,-57.+6,566-04578(9;96489/&+(207659913734464/227(7464+/*2024+3+77%:03-66,611(5;9%/*'*2)+,-'59567:/955&#((3&+26425435+,7$9+/4$+67299267+41'155'97:97-405(3978752,,.'97.5;855/)-383:::,-*3%6:673.979?<78<(<9(/8;83:7-24;06;6>/<:9:;=9;+7862%+080985=095#97669=)79:7>><5:9+<.==>6%94>1<,?:<;5#9<>;;51899,5>9>2=.830-26&);)8*89*85?;;0<<(8=0>86727:;>27<16;;78>9;;=>;5>>;<7,=;?88'*7958,<>1:>:>/6;9;138(1<8<<8:4??77728+33<9<-4:082.($'+40'5-79556*;/68:;;:86'-18=261*<21?7:;&=:8:),5'::19092<>+58;>:=0>534::('()>-=;87.1)7535=9=766.'956/587>988>99;'43:;/7=9?8:38<&3'3*72"/:<%;<8=$;5C4;:?@B6B8B?:/?B1<<<.C6=4@A;9(;AA?B@A<8=<99'3-@=B;BB::1=@?AB>;9&>B@:?>7=:98@%<=B>@;9%?;@B79&@;>9603;894$()#>;8%5=A8+7>>A5CC8:5>@6?;749@><145<>7@3=9B9?5C@2>B=7-9+/9?9@8-7>19==&:A6>>B?/=:<&><%<3@=@8>-B5>=;?=5+;5=@>A;<=?.6<::&99@(<>=<):>4>@-<;56=7*@$>@@>/A>8%.2=:@657@939:=6<34>@A7?A>A9@@@'>@??6=87BB>20A9;?@+@@AAB4@?@@B?.4@;B524=5@6<.>92277@/9:<9BCBB<7:<4AAA>8&C<=A=89=231>8<=-5;@C7<-;7A=C7C4;@A5>?A>8<0?<@'<:;6C<=>?,A@=?B;458<87>7>>74=(?6C1AA4C>6:63$;?:>=>=*/8:4=93,BB-?77;:5?29/=?0?B>8<@B<75;B==?)828=,93:??6CCC1A=2;.;1@4><<::+>@=4ACC=CB@:6BA;5;<2<-<:;4;34'8;.'@<7?<56@7C=>?B>>AB>A@<0078039<42@;?>7(;):BB>=>:B7?5.?075CA?A:A5=?<5=>/@B1;.9?6B?;;(>$8??6867;?B?;A9388=7>?2=:81.<:<'7:98-3059;1)3-::A>A+>?>82=681:'>?@>A8>-<=.@@>8A8&=A===.45A;@?-$'76@??A??+A=:?A?3>6A=<<3634'<%764-:;>;<54%&79?8B>?@7:>2><7<5:<&468<@,:<5A4<99<&?C;;=76;(7;0@:@=:;=)23>?(9=A56#9<;-28/-9<5;=@BA5@2;A9;B@A@9A?53>0-#0898C6BB<%:+?>,;:.@*22C6?B;527<8<<>&<:;?';?BA?5=?>5=.=;?9=:1A47;>+;>8B:CC5A==>>7.AC=&3A>(149':A@>5>:%::;;/8>;8><><7=9><6BB=/;A9>AA@0?6;6>6>848#/$%@&B?A8@6:7A:=53867;,<679>)/=-4?3=:1C9A3<@@<1@@B=:,A>?=B58??890=<42<<;$*>=?=0<::?<-:05?=<;<:6<1=9):7;%.:;A6?6@A+7061>.8??%3'<@@*4C19:3<6??9(2-9@=@>=6@5B>@98@>;6-:::>8@BBA-B?+??<-A@@=C;6?8>?88,5;#%74,879=.=6.0@?4B72A6B@AA;8<7@>?4C@?<&82=&56>@AA0;.@@1AB==92:-42515:98+;@B-AC1-B=>=)3=;?;'495=<4<9'7B>6>@6@7-'B>?:':;@6*>%<;AC9>8<@/<87165?@332'7B@@;8BC3=?9596.B@&4>B/>9@7;3@'*C1@,B=@,=+/;88?A*<7&205@AC48C==3@:A>=7+:=8>>;>0;<):(*4A<@@7>6;%;?;8:97;=;?:6/=(88)9828894$*9;>/254A@556>@/:;;==2;(384?;CA7ABC8B9?787-.'<=><:8'41A@4<:A@;'1@824;+93=?5.9?25>>(<:?B<4@;86=:;7:)9?<61006>0<>CC=<@?0:873:8<9?3,B,@A59<68;9(?<6<7?=><,9?=:;>/<><=->7A:0C@AC3;>6A0A6=<0B>7:<:::<@(/C;@;=7BB?A=@@C?=-89<<>.176@>B69@<7>9+:>@C;9=7C?>:&9<7<(795=.;3:;<;6:C5@BA==A@7??@9BA<194(:;?%=(=895>A,@/@B9=,749>1(9/;B;,<:?B=>;5>?3=8BCC84;?*8AA6>A=>>@(9>:>AB>&>=9?CB=BB=@)@1>A?A8@2@?<<>7>=9>>@B2:979(<1<;3>?8@793CBA3>B=>(>BC:648;<4:':@=6&55<+A?0:CCB.6:<+?C=->C:/7;?);?>>A<>)>>A@:=18=7?>>@<&B7=7=?B=57@AC @rCer/391/2103_58_CCS ATGGGCGGACACTGAACGGTTGATCGGTGACGCTGCAAAGAATCAAGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAGCATTGGCCCTTCATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATATAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTATCCTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTATCTTGGGAAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTATTTTAATGACTCTCAGCGTCAGGCTACAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTTATCTTTGACCTGGGAGGTGGCACTTTCGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTTAACCATTTTATTGCAGAGTTCAAGCGCAAGCATAAGAAGGACATCAGCGAGAACAAGAGAGCTGTAAGACGCCTTCGTACTGCTTGTGAACGTGCTAAGCGTACGCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGATTTCTTCAACGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAAGTCTGAAAATGTTCAAGATTTGTTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTAATGACCGTCCTTATTAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTCTATTGAAGGAGAGCGTGCCATGACCAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACGGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATCCTGAATGTCTCTGCTGTGGACAAGAGTACAGGAAAAGAGAATAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTATCATCCAAGAATTCACTTGAGTCCTATGCATTCAACATGAAAGCAACTGTCGAAGACGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCCGAGAAGGAAGAGTTTGAACATCAGCAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTCCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACTATTGAAGAGGTTGATTAAGCCAACCCAAGTATAGGTGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTTGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATGCACAGGGGAAGGAAACAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAAATAACTAGTTTAGAAAT + 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@rCer/392/25_2779_CCS ATGGGGCACTGGACGGCTTCGGGCAGGGCAGATTTATATCTGCGGGGATCAGCTGACGCTCCGCATTGCAGACGCGGAGTCAGGCGGCGCTATGTACGCTCTCTTCCTCCTGGCCAGCCTCCTGGCGCGGCTCTAGCCAGCCCAGTCCTCAGAATGAAAGAATGCACCAGAGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCATCCGACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCGACAGTGAAATTCTTCCTTGTGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACATGCCACCGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCGAACATGTCTGCTTCGTGCAAGGAGATAGTGGACTCCTACCTCCTGTCATCCGGACATCATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCTCTCCAGAAGCACCTGGCAGAGCTGATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCGAGCTGGACATGACTGGGTGGTGGCCCTTCATGGCCAACATCCTCTCCTCCTCTACCCTCAGGACGGCCCCCGCAGCAAGCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGACTGCATTCAGATGGTGACCGACATCCAGACTGCTGTACGGACTAACTCCACCTTTGTCCAGGCCTTGGTGGACATGTCAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATGTGCAAGAACTATATCAGCCAGTATCTGAAATTGCTATCCAGATGATGATGCACATGCAGGATCAGCACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGAGAGGTGAAGAGATGCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAACTGGTGGAGCCCATTAAGAAGCACGAGGTCCAGCAAAGTCTGATGTTACTGTGAGGTGTGTGAATTCTCTGGTGAAGGAGGTGACCAGCTGATTGACAACACAAGACTGAGAAAGAAATACTCGACACTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGCCAGGAGGTGGTGACACGTACGGCAGCTCAATCTGTCCATCCTGCTGCAGAGGTCAGCCCTGAGCTGGTGTGCAGCATGCTGCGCTCTGCTCTGGCACGCGGCTGCCTGCGCTGACCGTTCATGTGACTCAGCCGAAGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGTTATTTGGATCGTAACCTGGAGAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCCGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCGTTCGTGTGCTTGAAAATTGGAGCCTGCCCGTCAGCCATAAGCCCTTGCTGGGAACTGAGAAGTGTGTATGGGGCCCAAGCTACTGGTGCCAGAACACAGAGACGGCAGCCAGTGCAATGCTGTCGAGCATTGCAAACGCCACATGTGGAACTAGGAGGAGGAATATTCCAGCTTGGAGAAACCGCAGCATTAGTTTTTTTCTACTTGTGTGTCTGGGAGAATGAACGCACAGATCTATTTGACTTTGTTTAAAAATAGGGCTCCCTCACCTCCCCCATTCTGTGTCCTTTGTTGTAGCATTGCTGTCTGCAAGGGAGCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGGCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTAGCCCGCCCTCGCATGGCACCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGCTTCTTGACTGGAGGCCATCAACCCTCTTGGCTGGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGCTTCTGAGGTGGCCTCCTGCCTGGTCAGGGACCCTCTCCCCTTTCCTGGCCTCTCAGCTGTACAAAGCAGCAAAACAAAGGCAGTTTTTATGAAGATTAGAAGCCGGAATAATCAGGCTTTTTAAATGATTAATTCCCGCTGTAATAGCACAGGGATTTGGAAGCAGCTGCTGGTGGCTTGGGACCCCACTGGGGCCACGGTTTCTCTGTCCTGGTTCAACTGTGATTTGGCTTTCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGTTCTGTGGGTTTGGGTGGAAGGGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCAAGGCCCCGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACGTGTCCCTGGCTGCTGAGGTGCTGCTGCGCCTGCACCCCTCCCCCGTCTCATAGAGCTCCTTTTGACCTTTCTTTTCAATAAATGTGGATGGCGAGTTCCTAGGCCTGTGCTCCTGTTAGAGGGCGGCATGCTGAGGGGTCTGCTGGGTGTGGGTTGGACGCTGGGGTGTGGGTTGGATGCTGTCTGCAGCCCACTTGGGCACCCATGCTTCTGTCTACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGATACGCAGTTGCTATAAATGGACTTTGTGAGTTTGTTTTGCACTAAGTTCTGTGATTAACAATAAAATTCTGTTAG 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@rCer/395/0_1772_CCS AGGCGCTTACGTCTCAATGCTAATCAAGCTTCTTCCTGTTGGTGAACGGCACAGCATGGTCAGCGTCTCCACACCAATCTCAGAGGTGTATGAGAGTGAGAAGGATGAGTGGATTCTGTACATGGTCTATGCTCCCAGGGACGTTCGGGATGAATTGTCAGTGTAAACTAGAAAATACATCTATTCTAGATTTTTTAACCCTTACAAGGAAAAAAAGGATGTTACCAATGAGATGGATCAGTTCATCTAATCCAGATATCCACAGTGTGTTCCCTAGGGTGTTAGGAGTTGTGTTTGTGTTTCAGCGGAAACTGGCTCAGTGAGCCGTTTCAGCTTTGGAACTTATTATTTTAATGTAGGCTAGCTTGTTTTCAGATTTTAAATTTTAAATAAATACTTTGCTTCTTAGTTGCCAATAAATACACTTCAAGTTATTTTAATGCTCTTTCTCACTAATAGGAACTTGCAATTCCAGGAGTAATTTAAAGGCTTTCAGAGAGACCTGAGTCTTCTCTTCAGGTTCACAGAACCCGCCGCCTTTTTCGGGTAGAAGTTTTCTACTAGCTAGAGAGATCTCCCTAAGAGATCTTTAGGCCTGAGTTGTGAAGCGTAACCCCCGCAAAATGCATTTGCCATCAGAGTTGCACAAATGCAGGTAAATGAGGTGTGTGTAAGAAACGCCCTGACTGTAAACTGCTGGAGGTCCCCAGCTCCTAACAGAACTACACCCAAAGTCCCCATCTGCAGGGGTAGACATTTCTGGTTTGTTCTCTAGATGTTAACAATAAAGACACCACTCAAAGGAACTTGAATAATTTATATTTTGATCTAGTTTCTTAAAGACCCTGGAGAAAGAGTGGCATTTCTTCTGTTCAGGTTTTGAGTTCAAACTGGTGCCCGTGTTGTTATGGAAGCAGCCAGAGTACCAGTGTCATTCTGGAAGACAGCGGTAGAAACCACAAATGGTGTAACTGAAAGCATTAACATTCAGACACACTCGCTTCTGCCTCTGGCTTAAAGCTATGGATGATTCACGTTGTTTTTTAATGTTAAATGTATAACTCAATATTACTGAAAAGGTTCCCACATTTTGAGTAGTAGTTGTCACTGTTAGGTCAGCCAGCCATCAGAATTCTCCCACACTAAGTGCATGTCAGTTGTGGAGAAAACATAGCAAAAAGAGCCATACGCTCTTTACAGATACTAATGTCAAGAGTTCAACCTCCTCAGTTCAACCTGTGATAAAAGACCAGTGCTTCCACTACCTGCATGGGGTTCACTTTATAATTTTCTTGGGAGTATCACAGGAAAATCACAATACACCACTTAGACCCTATGTGTAGCAGGTCACAACTTACTTACCTTGTGTGTTAGATGATGGAATACCTGTATACATTAGTGAAAGCTGTTTACTGTAACGGGAAAACCAGATTCCTTGCATCTGGGCCCTCTACCGATTGTTAAAGGAGTTCCTGTCACCTGCTCTCCCCCAGTGCATGCGTCTGTCCACCTGGCTAACTTTTATATGTGTATTTTTACATTATGTAAATTCTTAACTGGCCTGTCTCGTTTAGACTGTATACATCATATCTGACATTATTGTAACTACTGTGTGATCAGTAAGATTCCTATAAGAAATACTGCTTTTAAAAAAAAAAAAAGTAACATGCTGAGGGGTGACGATATCCCATGTGAGTGGTCACTTATTATAGGATCTTTAAACAAGTACATTTTTAATGAACTAAGTTGAATAAAGGCACAATTAAAAACTG 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S((,,(&'%'##&(*))*,'+)'%&'*+#'*'),,-*)+,('&)&'(',&$##')*&)+('&-,,1+-),./&/1&,-+,+*1001)('),-'+&,/-',&,--.+,(+#.2*)&--0,1.'-.2/(%/*(&(%)-,&'&&*.12-'-0+0)#*+0,1--111*$(+*0,)"++))//&-/*$%/'&*+#$*0-.&$.'-()-*(&-..&/.,--(%.*,0-2)'-$#")&.(+%/&*/+,.2'$$).,.,'$+-,.%0&,+*&-((11-.**&%(((.,-/2,12+-,1+(..0./0/'.,-'-+&1%+,-1/#0)&&+/1-0+$0%..%)1+&01)0%(+*&,-1/&,)*)/1/1012,,.&++1.+,+.)*+%%,,)%.*$++)(0-$$&*(/*,1-'($.-,-+0/.-*.&,'%1///01$,1))/.060(555)101145'66*14(.1%)/..2+226552-4/1)/)36*/1*0(1.-44-50./2202///01.1+/%(+.'--50*25.26%2-/)'*&-'/*-(*-,1&32'*+&)**'1-38+2.1+3011&+1/+1014424,-&325-13,$('0,77/2;&0)132/9'&054-,/4.6*586300(1488602'/25)22:9(,'1,0'+.2(44/-20$,+,43534$(',1-..-)66$1/-(,374416+6-+651,26527+03./894/(1/+52)54&1%33/,-+&83'.0+-(3/.,#*$+*,$),-/)1**,($$-,.2*554.-1-*,10+.(,-*$,&&1(/-,25.063,34/3.-+$/)-51$,//2'3-''""'0187:::75%2./*2,,41,/66502.*198-89;-<<0*;91,4/*(#5030>(;;::)77=<-<4%149:/0;;=>=0<;3:4838&4.623&$$,21524?153/3899985;?76:0:9<98?7<=1.6,,32#*2//3.7113143(35810.2/69,.11555682610)*)&2-./*,%134265:1::56-858706714:9655)53)412365:862:-91664-/19.&/+6352932/6058737(33:8305(5799:5,-+655295411740)/237.++2170,1812//33159890617717.*45905(38561-96675651*784+41556,6866485/76.10.6-+2871553.-/,//411+123.'+&.4253:628747%.46.8,9+4458,&5569:6:356:6-+&98:3,39318/3-867'3786+840-+/$-40++4)65%,+,,509635%/5697+83,%59.(765&3314-874745253(58:3::734'+/+8.7'7-&4%&*&-/+$0,0(.*$788)513192()4/4250521.-)-+8803)--)*)++)-,%.0)/670/20246)9+7698*68,47-85-,345:59+50&3.::.42152*3438:669561.-.*1652/3257702255012-3/614597:56;9)84''49//63/5'44,/37..94&++$++,8518.8673;9;,3165.4-803/5.264/.--(54&140055076654,('0...535)/0%0,-0::63/9%3+/'.(-4.17087086.%.%563$-/1226875322310757645582.976222$46566,4-/92,-,-6)7669:$:0%;6==>076'36475&45)32.2&.*/+9468188 @rCer/396/2235_77_CCS ATGGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTTGCTGGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCAGCACAGAGAGCGGGGCATGCCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAATG + IKIK?@DC8JKIDJ>KDJHEJKGEIIIHG@KJFKIKKJG@C:FKBJJHIHJFECHK8GIIGCCGJHFB>BDIF:88I(DIJHHJHJH8.JKJE;IDJJ?FJAEEKJJF@KIHGCKGEJK9K=KFIKKJBG@GGHHKJFJ;>IAKHJJGEK?KKCHG5@JBJDJIKHHC7DI4EEKAKJGGDCJ:HGFEIFHK;KHEIJGIKIJBCKKIK@FKAHJJFEFKHJCKJIIK:HIE9HFF-EC?D5FKJEHIFJ:?KKKE/@@>E9GBEDHHAID<9@AAFADGKJJJ=0EIHFC9IGJK><;:BH)I:DD>IK5JJGHKBGCFJHJE@9JDE@EIKKJKEIKCGJKHFI@IIED?BKKFJJIIIEIIHF9CE.?EJDAJIKJBJGFDIFG?DG7JDGHHAGHJDJJFD4EIG2IJGJGJKK9KJFFGEEKK2EJE@E<6>JDGJ@GHJI;CFG6BEIH9CHI:BHEFGHD;GJGJKIGACJJIKJHFKKBGHK8;C)GFAIDECBHIE?FDECFC?7F@=458535;>B;FCFEDAD?8GFE5==;81938AEFGAB<4DFBFHBBGF@:B;2;A9@=4>BF9B>>4?HIEHAFFE1@?9/A?>BAJHFIFFBA?>E3@BCACAA.<=8=@+<@?+@=84?96;829@=FD@ID?9CFB?DFFHGCB@EEDHCE8>G9ACFA>AC=H=9DI>DDDEGD:C?EIJ?=;>?-2/?HBF@BFIF>,A4G4H>G;F:CGB5BA:E:DIG?HIEHEEGEIFJIJJ8GGCG?EBH4=FDIHFF>EIGFGJBHFAEB@DABFBC>IED?AF=HCD?E@ACBAHBAAB3C?;?=:=99A:>;,<9>E7:2@9F:BD@:>/6@&><:3@BDA@==DBD=<=ADDE@BC:=7CBCDBCC:@F@>=8:76;2?;49EAAA@)@8>9;??>:BB-CE??4DB@=:>9=FF@F8EB.CCE?ADEG@EDBAF@D<66BDBBFED>=8DCD@:<@E6-8BCBEEC?6=EA=>;==51:751??7?1B:?@599)>7:>=ADCCA@145;5AA;FF;C=6A=FD.DBEAAG;?<=.D8G@:A@9:>4?B<;EA@CBD:?DFDE>A?EE?ED@D@:=DD1DEGBAFFFAE?DFBE?4>GCA>A/B=?F;E@D@@1BDD6;@?1?A>A?9B;B7:6;:9C9B8@8:6*7566:?A@>6;>7???;;63+93=@=:896<3>?9?*3/224>?@>>3>E?A79)ABBCC/799<4;8:)?;>>;?;8>6GECBEE@4A9==:7=:A<==6A@@CEEF@E=FGA?>C:DA><35=4:A34483A:2894>A@99.>=A=F?<>2>?6688>5:=8A<@@67-';2D:&5447()7:83ED:98/=:69;97>??1DC:=C9>=B.<1=;->;64:6@7C=CA=DB:@CFA@=7EBC?FBDD>D=856374;<;3:86187/BB@@>:?@DFB@:(<6DABAGE>CD?>8;8??A7B?:6@;C=C654;<6A=$8BB1B?FGG<:@CD*:A<5>>.=AEG@EBD; @rCer/397/1715_58_CCS ATGGGGGATATTCTGGTAAGTAAAGGCTGAGGACTCCTCCTTACTTTAATCCTCAGATCTAGACAACTCATGACATTTTCTTTGACCAACATAGCACATGATGAGATATCAAGGTAATTAAACTAGCATGCTTGAAAAAAAATACGTAATCTGTTTCACCTGTAACTGTTTAAGCCAATGAACTTTTCAAAATTTATGTAATATGGGACTTTTATGTAGCACTTTATGTTTTCATGCTGCTTATTGTTTTATTCTACTGAAATAAATGAATTTCAAGGTTCTCAACTTTAATTTCAAAAAATTGTTTACTGTTTTGACTATGGGAATACAAAATTTCCTATTTCAGGAGAATAAGAACTCCTTTTGTCATTTTTGGCTATGAATAAACTTTTTGGTCTCTTGAGACCACCCATTTTTATAGATCAGAATCAGAAAACAAGTAAACCTCACGCATTTGGACTCATTCGAACAAAAAACCTAGGCCAAAATACTGAAAAGCATTGTGGGGAAAAGAAAGAAAGGATCAGACTGTTACTGTGTCTATATGGAAAGAAGTAGACATAAGAGACTCCATTTTGTTCTGTATTTGAGATGCTGTTAATCTGTGACCCTACCCCCAACCTTGTCCTTGCAAGAGACATGTGCTGTGGTGACTCAAGGTTTAAAGGATTTTGGGCTGTGCAAGGTGTGCTTTGTTAAACAAGTGCCTGAAGGCAGCTTGCTGGTTAATAGTCATCACCATTCTCTTAATCTCAAGTACCCAAGGACATGCACATTGCCAAAGGTCGCAGGGACCTCTGCCTAGGAAAGCTAGGTATTGTCCAAGGTTTCTCCCAGTGTGATAGGCTGAAATATGGCCTCGTGGGAAGGGAAAGACCTGATCGTCCCCAGCCTGACACCCGTGAAGGGTCTGTGCTGAGGAGGACTAGTACAAGAGGAAAGAAGGCCTCTTGGCGGTTGTTGGCAGTTGAGATAGAGAAAAGCATCTGTCCATCTGGGCAATGGAACATCTCGGTATAAAACCCGATTGTATGTCCTGTTTACAGAGAAAGGAGAAAACCGCCTTAGGGTGAAAGGTGGGACTTGCTAGCTGCAATGCTGCTCTTTATGCACTAAAAAGGTTTATGGAGATGTTTACATATGCATATCAAGGCACAGCACTTTTCCTTAAACTTATTCATGTCACAGAGAACTTCATATGTCTTACTGCTGACTTTCTCCCTATAATGATCCTATTATCCTGCCACTTCCTTTTCTTTAAGATGGTAAAGATAATTATCAGTAAATACTAAGGGAACTCAGAGACCGGTGCCGGCGTGGGTCCTCTGTATGCTGAGCGCCGGTCCCCTGGGCCCACTTTTTCTTTCTCCATACTTTGTGTCTCATTTCTTTTCTCAAGGCTCTCATTCCACCTAACGAGAAACGCCCACAGGTGTGGAGGGGTAGGCCACCCCTTCAAAGCCTCTGTGTTTTTCTTTAATTGAAAGTATATGTAAGGTTAATGCATTTAGTGAACTTGACTAACAAAGACTAATGTGCACATTAACAGATGTACTTTTTAAGGTTTTATGGGAGGCTGTGCATTGCTCAAAACTGTTGGGAACACCTTTTGAACAGTTGCCTTCAGAACTAGTTTGAGCTGCTCAATAAAACCAGT + KJKKKK8KKKKCKKKIJKKKJKJEKBIKKKKKKKKKKHKKKKKKKKHKKKKKKKIKKKKKKJHHKBJKKKKKKKKKKKDKKI?KKKHK7KKKKKKKKKJJKKKKJHJJKKKIKGKKKKIKKIKK@HHGIJBK3JKKKKKKK$KIIKJKKKKKKKKKKJKJKKGKKIKKFKHK6JJKKFJKKDKAKKKKKKKGD&H:JJKDBKKKKKK>KKKEJKKK2KEFJIJEK=KKJKJKJKKAKAIKJKKAKFHJKFJKKKIKK8KFCKKKKKGKKKKJIKKGFHK=IKKJI4KFGJKKKFKKKKKHGHKDJKKIJ-KKKIHJKIFKJ@KJGKKKBKJ7@HIJAJCKHIIIFEHK>KKKKJKJJJJKDEHJIKKK)KCGII:K;JKK@KJKJEHKK=HJDKCKJKKKGKKKDJKKGIKKKKIKKKKJAIFAJ;JKHJJIHBHKJJJKKHKCKKIHKKJJKKKJCCI@KK@KGIIKK8KKIKIJCGKKJJCJJCJCFJGEKDDKFFHKKIJ;K@KKKK@K=KHKEHJKJKEJAKGJIDJFFIHC?I?CCK4ECGJJHKIGCCK;JKDKHIIIK-HJ0JKD:KKKIKA:JC8JKK8HIAFJ=KKEKIKKIIKKFK?JGJKKIKKAIJKIKKHJKKJKGJAKJJKCJIKKDFJIKIJKJK98;H&K4KCGKJEKGIKHKKEF>GF6JDJKIKKKK/IKGIKHKKFFGKKKKHKKJGKDHIKBDIKGKDKKHI;HCBK8JKKDIGGIKKJJ@JKJCJKGKKKJJKKKKKJK>KKIKK4I0KIKKKIJIJKKKDJFKJKKIKGKKCFHKKBKKJKHDKGJKKJGKI=KGJKJKKIJIF:KG@JK5FK>FAKDG@;JI2KIIKFKEKJKJKIKI7HHKFKHG5KICKHIJ8JIGKIKKHKAHKKCEKKKKKBJKIDKJK8KKIJKIBKJKDCKKBIIIKKKKCKEKKCKHKKJJGJKKK?KKKJHKKKKIKKKKJKKKKKIIKIJKJKDKGKGKJ8KKEJKJIKKI:FJJHIKHKIEKBI=JKKJJIKAKIHHJKHGKKK@KKKH/HJDHJFJKGJJJIKIJKKHKJKIJKIHK@KKJGGKK>KJKKJKIKKKGJJJJ@KCKKIIKGKK:BJKJKKKKEJKFIHAK;GKJI:KKKJKJJKKK1KJIKCKKIKKJKCKKIK?KKFKFKKKKKK;5:67666*31:32844=,;6(+:58/7<+4===98<4?:=54&75>=?986?36<7*55<0>9;9?:8>764354645675/7+>6=;=>:237<;<4.86<48-14==47<689912<1:?9?6;/8/80,79=18;65220==?8894<;3;=875899(6688<;367=-72)8=6?8<6988,5:=<7:;;>;8<9:;<>6;8)5<;18488<8?89;6;82;988>=:>;87:<<)>>:==/;6<%:=6:3<:9998:=<=;8>=44<79,<7;;:=:<90=:6729*353808443,)5=6=:;<;042).68.9<58;9><>);;7;:64*3=82752+637/=84=<=8:67:67695:=;6::;:9229<<<5991=;?>>?987=>>:;7796<;8*7.:168881936742044956;5:4::/7495+<4,.6799713726.+00240:07164843-674383(,22761*16/.*0,-/42(00633.&60/7742*30;6:865351/.2/02151&557246.0()&-23%771/.888+1567.788.00110/412.214:7/5-324693+13.74<<9570122199458839560:=2;98885940,7-5=<9561056-'142*678+146-66/1386740:65<54/791227./-+4:8-8:7:<9;19695;,4/,3274<296/.69><7-873.046.1766<987;37+)%618=>99'.877788:36><789:=0>:>>75;99>3;<<813:<.673*2(43=*62=>9890+3:994=0>:4;;<*=4,77600//2625:798>;<9;?=>,7?6>;:42:;>:=389;3>7<=;:;483=;>5:?:837=63<;5:9=?987842;:44+47;:788(>9335+446<8;6>9<>592*:918=6=<469:::=(586<9=?=;598293632372;=99581$-5783864863;;;;9619>;95:99:72293>4<;;;?585=9:6;>7<1:659398;:30;6<=<<7>?8?>98:7=;;57<;;:=97;8767:<<0<8:9<=8:=::4578?:;>59:;6;97-6*;66993728688;;7602<9=-6.+34;5=<<>931.8<2:>3=5<>48654=8:86=7;8:/576>;7;7==8868=8829/821,4457033793<06?5255-240:33=2:7;97>5>496::417676--435-+/6654:6+646:4;8=3:898=9::>;??<=5<:8>=<;=7=::613==9:8;=2987=6718499-:93(;;-=;:978>==:>::86,5<79;815992;>86>5;645?;993?=7739941=9:7:63:486*<24:303; @rCer/401/1101_56_CCS ATGGGGGACGGGCCCGGCCCGGCCCGCCTCCCGCCGTGTCGCGGCGCACGTAGGTTCCCCGACCTGACAGGTGCGCGGCCCGGGCCGGCTGGGCTCTCAGAGCCGAGACGTGGGGCCCCGACCCGGCCGCGGGGCTGGGCCCGCTCCGTCGCCCCGACCCCGCGTGGTCCGCCAACTCCCTTCTGCGCGCGGAGAGGACGGGCATTGTTCTCGGGGCCCCGGAGAGCGCGAGAGCGGCCTGAGGTGCTCCAACAGGGCCCCCGAGCAGGACTGGAGGCAGTCAGAGAAGGACCAGTGGGAGCAGCTGGCAGAAAGCAGGCGGCAGAGGGCCGAGCTGGCCAACCATCTTCGGGCAGTGCTGGAGGCCCTTTCGGAGCAAGCCCTTGTGCTGCAGAGGCGAGAGCATGAGCTGGGACTCAGCTGGTCCTGAAGCAGAAATACACTCCAGGTCCCGGAGGTACCAGTGCCCTCAGGAAACAGCTAGAAGCACAAGAATCACATCCCAGGCTTCATGAGGAGATGGCTGAGTACTGGAGGACACGCTGGCACCAGGTGGCAGTTGCCCTGAAATTTAAAGAGGAGGAATTGCAGAGACTCCAGAGGCAGAGTGGGACCTGGCCTCCCCAGCCTCAGCTTGTGGATCCAGAGCTGGGTACTGAGCCGTACTGGACCAGTGGGCCCCCTCCTGGGATCGCTGGACTTGGAGCAGAAGAATTCCTCCAGGACTGGACTGGACACACAAAACTTGGGAACTGTCAACTGCCCTGTTATTCACCTCGTGAAAAAAGCTGGATTTAAATGAGAGCGAATGGAGCTGACAATTCCCAGAAACTCGAATTGAGATGGTGAGATTTTAGTTCAGCCCAGGGCGGTCTCATGAGTGGGTGGTAAAGTTGAGCTTTGAGGTGGTCTTCAGAAGGAGAGGAATACCCTCCGCGGGCAGAGCTTCCCGGGTTCCGGGCCCTTTGGGACGTCAACACAGGTCTAGCTGCCCTTAGGCTCCTCCGCACACCCTGGTTCCAATAATAAATCCCTTTCCTCTCTG + KJJGKK'JJKK&KJGKDKKHKJKKKKKIKKKJKKJGJHEIKJKIKKKIKJIEKKKKKKKAKJKKKKKKKKHKKKKKK5KKEKK1KGKKKKKK1KKKKIJKKKKIKKIJIJKKKK;JKK8KIKKJKKKFJIJKK2IHKKDJK:KKKKKKJIIIKIBKFKKK:KIHEI:KKKKKIKAKKKKGKEEKKKKIKKKFKKKIDKKKK>GJKJKKKKKIJJHK>IKEKKJKKKKK>KKKKKKJFBHKKKKKKJKCDEHKJIK=JKKEKKJJJ7KKK4KJKJG5KHKKFKKKIJJEKI?KKJJKJJKK&=HKK?GJ@KIJKJFKKJKKHKK>KK:JJKKKKKK9KKKKJFIDCGIKHDKGAKEJHJHJHHKJKKKKHKKDJFHKKJGKGF5JHKKGGHJK@KKKKKKKK?KKJKK0IKKIIK?KKKKKKKK>KKKK9KKJKKK;FIGBJIKHKGA@EDJIKKJJJJKEE?K8KKIKKBJEKKKKKKKG>IHFIKIKK5IKBKK?KIIKJKKJ>JKKKJ;JKF<>@=HHCJKKJKGGHIJK?EKKKEDKIACH=JKKKJJJKJKKKJKJKIKKJKII:KKIJKKJCKHFKKDKBJKKJJK=FCHJFEJI1IKKKKJAKK9CKKEKKJKIKFKKKEKKKKCEK>IKK-KGHGIJKKK3KKKKHKKIKJ9KIIK;KHGEBKHF>KJJKG=KJKKKK?KKJKKJI9KK3KK7IIKAKKAKKIIK&KKGKJHFGJCKGKHKJJK/JKIJKKK?K?DKGJGKJJKCKBIIDKKFKKKKHKJK0KJ7CJK$IKK8KK6KKKKKKJK @rCer/402/2073_63_CCS ATGGGGGAGGAGGAGCGCAAGTACATCGAGGACGCCATCGGAGAGAGCGCGAAACTCATGAACCCCCTCACGAAGTTTAGCACTCCCTGGCGACGCTTCTTCACGTCTATGCCAGTCTACGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTACCTGCTGCTCATCTCCCAGCCTGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTAGGCCTGGTATCCGCTCTGCCCCATCTGGTCATGACCATCATCGTGCCCATCGGCGGCCAGATCGCGGACTTCCTGAGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTGATGAACTGCGGGGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCCAAGGGCGTGGCCATCTCCTTCCTAGTCCTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCTGGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGCATCTCCAACGGCGTGGGCACACTGTCGGGGATGGTGTGCCCCATCATCGTGGGGCCATGACTAAGCACAAGACTCGGAGGAGTGGCAGTACGTGTTCCTAATTGCCTCCCTGGTGCACTATGGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAGCCTGAGGAGATGAGCGAGGAGAAGTGTGGATTTGTTGGCCATGACCAGCTGGCTGGCAGTGACGACAGCGAAATGGAGGATGAGGCTGAGCCCCCGGGGGCACCCCTGCACCACCTCCCTCCTATGGGGCCACACACAGCACATTTCAACCCCCCAGGCCCCCACCCCCTGTCCGGGACTACTGACCATGTGCCTCCCACTGAATGGCAGTTTCCAGGACCTCCACTCCACTCATCTCTGGCCTGAGTGACAGTGTCAAGGAACCCTGCTCCTCTCCGTCCTGCCTCAGGCCTAAGAAGCACTCTCCCTTGTTCCCAGTGCTGTCAAATCCTCTTTCCTTCCCAATTGCCTCTCAGGGGTAGTGAAGCTGCAGACTGACAGTTTCAAGGATACCCAAATTCCCCTAAAGGTTCCCTCTCCACCCGTTCTGCCTCAGTGGTTTCAAATCTCTCCTTTCAGGGCTTTATTTGAATGGACAGTTCAACCTCTTACTCTCTTTTGTGGTTTTGAGGCACCCCCCCGCCCACCTCACTTTCCTTTATCTCCAGGGACTCTCAGGATAACCCTTGAGATCACTCAGCTCCCCTCTCCTTCCAGAAAAATTCAAGGTCCTCCTCTAGAAGTTTCAAATCTCTCCCAACTCTGTTCTGCATCTTCCAGATTGGTTTAACCAATCACTCCTCCCCGCCATTCCAGGGATTGATTCTCACCAGCGTTTCTGAGGGAAAATGGCGGTTTCAAGTCCCCCCTTCCTCGCCCACTTCACATCTCCCTACCAGCAGATTCTGCGAAAGCACCAAATTTCCCAAGACCCTCTTCTCCCTAGCTTAGCATAATGTCTGGGGAAACAGCCAAAATCGCAATTTTAACAATATGCCTCTCCACCCCCATGCACTTTTTCTGACATGGTTTTCAGGTCTAAATAGTGGCTGCTCAAGTCCATGAACTCAAAGGTTTGAAGCCACCACCCACTGAACTCCCGCGTGGTGGTTTCATGATGCCCCCTCCCCGATTCCTCGCACTTTATTCTCCTGGGTGGTTTCAAACTACCCTCAGTTTCTCAGTGGCCATTTGTCATGTCCCTCAGGGGCTTAATGACTCAAAATCTGGGATCCTTCCCCTCTTAGACACCCCTCTTTCAGCTTAGAATTTGGGGAACCTATAGAGAAGTCACAGAATCCCATGAAAGGGAATGGGGCAGGGGACAGGGGTGTTTCTTCCCGGTGCAGGGTTGTGTCTTTGTGTCTCTGTCTCTGTGACTGTAAATCCTGCCCTGCCCCACGCCCAATAAAAGCTTTAGTGTACAGGCT + HKKKKH5IKHKKJKKKJKKJKDKKGHIKKKFJKHKGIKIK@IKKHKKKKKKKKJKJJKJKK9KKKKBJKKKKKGKKKJ7KIJJHIK&KKKKKKKKKK@KKKIIIJKJKJHKKJKKIIIIKIIJIIIKC7JKKJKIKKKKGJKJKJKKHKKKKIHJEDEKIJKKKKKKJIKKIEFHKK>KFKFKKJBEJKK>KKKJKKFJ@IKDKKFJKJKKKKCKKKKKKKKKJKKFKIKKJKEHKKKKIKJKKKK4HJJIKEIHGKIKKIJFGKKKKKHKK.JHFKKJGIIIKKJJKHKKGAJKJKEKKKIGIBC@FKIHCJKKGKJKKHJKJJIGK?KEJKKKKKJKKJJGFHKFKKKKKIJI&HKJIK=EJJKHKDKKKJKKIJIKKKKFICKJ>?IIBKKKJJKKJKJIKJKGKKJKJIIFKBKFIKKJHCKKAJKEKJIAGKKJIKK5KKKKDJJKIJKIKKKEFJEIJIII>H8JJGHKJIKEKKKJIJKJJJFKIHKKK2JJHJJJJHJJHFJJIHCJI?JCK9CIJKJKCKJKKKIBKKK@JGKKKKGGJKKK1J@FG@3B7574-5C?39HIBF?D&:;BICIFEJIJHIIHEGFIHEIJFFJJFKEFHJJCJIHKJKKKFIH?7CJICKJI@HFFHIIKJJJJIGIKBJGIJ9JJKCHFJIIIJIBFGIH;EKIIIBGGJIIJJHIJDEJGHJ0JBKGCAIKKJJIFDK2HKKIJEIJCFH8DJEFKGIJ6IKAFJ=HJGKK9FHJKHKKIE*CJKK.H@IGG%GJDFIIH@-GHK;JKJJKIKJF:K>CJKIBDF@DE?KKKHKKDKKKIK1IKFKKKI>EGKHH0BFEHAJK:HGEKJJKKJFCDDIHHJIJK7JJJIKKGJAJGIKKGGE?J9>HCCIJJHIJIIJJHJHIJIAJGFHKFFA?JKFIJJFKKKFJIJJHK>IIII4JDDJI:IG?KCKJHIFGKFFKJKGIBJI?HKKIJJJJHGEIJEKKKK;JKK;JKFIGCBGG>JKKH?>JKIJCGHJCFHDHGJJKK:HIKDKKIEIHJAJFGJJHBH,HKK=IKHKKKJKKDKKKKFGKIIKJKJKDKKIHIJKHJHJH=KKIK@JJKKJJKBHHFJB>KKK1GIIJAKIIFEAHEGI3KJIKCJJKKIJJDJAEHJKJKIKAKKKAHJEJJHKBKEJGIIGKGJDFKIJIJFI@FI>E;JGE@5JCFJKJIKHHHKJJKKKAIECCKFKHJIK=JKGJFKH=GDKJIHHJJKJCIHKKKKCHHG3@K:H?3IJ?JHCB==KKJJ&JCKHGJHKI=IGICE:HFCB9II%HAKIIKD:C@D=JCKGGJK+JKKJ=JH:JHCHH6K9GGHC;IFKBEJKKAIGGJIJKIJKGIJ8EGJICKIFKKBIEHJCFKHHF(=CJIGHKKFDHI*HGKHHEHKG7KBGJKCABKFIJIHF%8?CHJ)D88BGF,@HKHIEFJGJIIHJ@@C @rCer/403/0_201_CCS TATTCTGTAAAAGTGACTGTTATAATTCTTTTAATTTATGTTTCAATATATATAAAAATGCATCTGTTTTGTTTTTCCCTTTTTTCTCCATAATTTTAAAAAATGAATCTGATTGTTGTCAACATATTTGTGAAGGTCTTGTGCTATAAAGGGGAACTTCCCCTAATAAAAGGGCCTTGGAAACTGCTGGGTTTCTGACTT + S$$&'$''#''$#$'',-)&/+.%)*,'%+*++0/2-11.%+)0.1(%'*(+,&,--&&-+/-011-00-+#-..-%**'/100//0,/,+*+)01.(00/.+0.12-10)),0,,10(.,1/(+,&'/.,*+1#'+))-/00.*)%,*0&(.01211/*0---101'1.,&,--2'++0,00$%%(**12),,+(-#%'+ @rCer/407/1717_84_CCS ACACACGGCTGCTTCTCATTCATTGTCTTGACAAGAGCATCCTCAGCGGGCGAGTCCCCGGCTCCTCCAGCTCCTTCCTCCTCTTCCTCCTCCTCCTCCACCTCCGGCTTTTGGGGGGTCACTGTCCTCTCTCTGCAGCAGAATGAGCCGGCAGGTGGTCCGCTCCAGCAAGTTCCGCCACGTGTTTGGACAGCCAGCCAAGGCCGACCAGTGCTATGAAGATGTGCGCGTCTCACAGACCACCTGGGACAGTGGCTTCTGTGCTGTCAACCCTAAGTTTGTGGCCCTGATCTGTGAGGCCAGTGGGGGAGGGGCCTTCCTGGTGCTGCCCCTGGCAAGACTGGACGTGTGGACAAGAATGCGCCCACGGTCTGTGGCCACACAGCCCCTGTGCTAGACATCGCCTGGTGCCCGCACAATGACAACGTCATTGCCAGTGGCTCCGAGGACTGCACAGTCATGGTGTGGGAGATCCCGGATGGGGGCCTGGTGCTGCCCCTGCGGGAGCCTGTCGTCACCCTGGAGGGCCACACCAAGCGTGTGGGCATTGTGGCCTGGCACCCCACAGCCCAGAACGTGCTGCTCAGTGCAGGTTGTGACAACGTGATCATGGTGTGGGACGTGGGCACTGGGCAGCCGTGCTGACGCTGGGCCCAGAGGTGCACCCAGACACGATCTACAGTGTGGACTGGAGCCGAGACGGAGGCCTCATTTGTACCTCCTGCCGCGACAAGCGCGTGCGCATCATTGAGCCCCGCAAATGCACCGTCGTAGCTGAGAAGGACCGTCCCCATGAGGGGACCCGGCCCGTGCGTGCGGTGTTCGTGTCAGAGGGGAAGATCCTGACCACGGCTTCAGCCGCATGAGTGAGCGGCAGGTGGCGCTGTGGGACACAAAACACCTGGAGGAGCCGCTGTCCCTGCAGGAGCTGGACACCAGCAGCGGTGTCCTGCTGCCCTTCTTCGACCCTGACACCAACATTGTCTACCTCTGTGGCAAGGGTGACAGCTCGATCCGGTACTTTGAGATCACTTCTGAGGCCCCGTTCCTGCACTATCTCTCCATGTTCAGTTCCAAGGAGTCCCAGCGGGGCATGGGCTACATGCCCAAACGTGGCCTGGAGGTGAACAAGTGTGAGATTGCCAGGTTCTACAAGCTGCACGAGCGGAGGTGTGAGCCCATTGCCATGACAGTGCCTCGAAAGTCGGACCTGTTCCAGGAGGACCTGTACCCACCCACTGCAGGGCCCGACCCTGCCCTCACGGCTGAGGAGTGGCTGGGGGGTCGGGATGCTGGGCCCCTCCTCATCTCCCTCAAGGATGGCTACGTACCCCCAAAGAGCCGGGAGCTGAGGGTCAACCGGGGCCTCGACACCGGGCGCAGGAGGGCAGCACCAGAGGCCAGTGGCACTCCCAGCTCGGATGCTGTGTCCCGGCTGGAGGAGGAGATGCGGAAGCTCCAGGCCACGGTGCAGGAGCTCCAGAAGCGCTTGGACAGGCTGGAGGAGACAGTCCAGGCCAAGTAGAGCCCCGCAGGGCCTTCAGCAGGGTCAGCCATTCACACCCATCCACTCACTCCCCATTCCCAGTCACATGGCAGATAAAAAAACATAATAAAATGGCTTTATTTTCTT + KKKKKKKKKIKJKIIKJKKKKKKKHKKKKKKKKK7KKKK9KKKKKKKKDKKKGKKKK.JK$JKJKDFKKGKKKIKKKKKKKJKKGIKKKKK9AKKGJKKKJKCKJKKKKKKKKKKKKKJJKKKIKKKKKK=JKKKKKKEKJKKKAKKKKKAKKJIGKKKK@KKKKKKKKKKKKKJKKJKKKKKKKKKKIJKKKKCKKKKKKBKIKKKKKKAKIKKJJKKKKKKKKKKJG9=IKI:=KDKKKKKKKKEKKKKKKKKKKKJKKKKKJKKKKKKKKKKKKKDKKKKJKKKKKAKKKKKKKIJKK>KJKKBKKGKJKKGDIKJK3KKKKKKDJIHKK6KKKKKJKKKKKGKJK-KKJKIFKKKJJKKJKFJKKKKHKKKGKKFKKJIKKKK:KKKHJKK=KKKFKK:KKJKKKKKKKKKKK2IKKJI@IKKKKJKKKKFKKKKKKKKBKJKBKKKKKKKJKKKKKKKKKKGKKKKKKKK@JKKHKKKKJKKKJKKGKKKKKKK>KKKKKKKKKKKKKKKKKKKKKHKKKKEKIKKKKKKIKAKKKHKKJJ?KKKKKKKKKKKKKKKKKKKKKKKJKKKKKJKKDHK6KI?HKK$KKJKJ.KKKKKKKKKJKK9KKKK?KBKKDKJKKKKKKKKKKKFKKKKKHKK=KKGKKKKKKKKKKKKKKKKKKKKEHKHKKKKKAJK2BKKKKIKKKKKKKKKKGKKKKKJKKJKKIK;KKKKKAKJAIK7KKKKKKKKKGIKI;KKKKKKKK@KK=KKKKKKKKK0KJKKKDKKKKKKKKKKKKKKKKKK,KKKK?JJKKKKKFKKJ4KKGKKKKIIKK3KJKEKKJKKKJHKKKKKKKKK+KK9IKKK@KK;KKKKKKKKHKKK=KIKKK)KKJKKKKKKKKK2KKKKKJIKK>KKKKKKIJAKKJKKKIKK-KKKKKK:KKKJKKEJKKKKKKKKKK4KAKKKKKKKKKKIKKKKKKKKKKKKKKKK8?60@8;=/@2:>B=<=6?:?2>AF:7B>D68-816;9%4+=>E>CD5B<@6):D8CD?A.>9BC4@FDF?0BAB><<.B89/0?0=:7:BD>=BH9D@E@@>>C=='BBI=HCB4DBF9HEB4@@>;<=(=B*;(AF82B5071-/;AEAG<CE7F;A6EDH4EFGICIAG9HH?EFF?IC@BE>;$BDI?H>JAIFGF?EE6G@C&83H3:G=E?D,A9BCDBF08?G:7BG3F0?>C=$=?<3<E:?EC6G7BE%(+DGF3?F@%9;CDED<(@F7=EGGGF>J>IH?CEDDF9E;DGFJ@E@1FDI5A-FFGEDDG>G5GF<=F/C>DCGD1;1>:6;EACGB=>DFCA@3HJB@?0CDDD8EGC=C(-@B7??D@EA(=B%HJEI/DAE3=BCH2ACIB8BBDH@BE7>DJ5HHEGE0G6@D.EFE:C6F6CIDHJ?EF=C6?HGIHD=?EFFE7GGHI;GIAGDECIEA;DBCDF.96I3BBFH;?>EF5IHCHFG;IJGBGD7JIEGD@E5HFEDEGF@;A<9H9EEB4,?CA6%88?=>@;B8FCB=4;D@4BA?ACBC9(@=.<:9/5056<>;969<@#-.=>A3A=>?-683+@735)8'00;:79:?=?;&;9/;>A54)<9520::%=C@2;;(:6;8'7=7@;96503:55<95:4;0;:>>/<4:?7@A6<3ABA=B=4$:9?@76548>=A6@/46/8(6.=><(<5,:'<5/B689;,@;@,A9ACC81:@3A>4/>.<:=;066--@<:;?:8CCA:?<=<62+78?1:4>7B>9@)&'+B3<@=;)9-5;=>0+20,2-0843?488<>@08>B@=)>B?016;>;@9+:=0=<7/98:63<9,<@7788*?:C:9;<;/2&;=68@?.>C?=3;82185;4838)@2>;BC6:>99&3><0775/A@;)442;(<=>>C>;'?6:(683,26762:95<88=;4:A;<9';7;,85=,/1,).)/<;@C7)5A3C:26:>=3;$<@?2@4A=A=;890%3?@96A;80?>:06692757)),;0.=>:;7A690@?:0A5;>-?@;GA@/CAB+<;86=@C7<8@*;A@CF);:7:967537)555:06765.2-7-,6355+66+5&/02599918794184.432-7:;423/'312/ @rCer/410/1937_61_CCS ATGGGGCTCTCTGCGCTGCTGTAGCCGGACCCTTTGCCTTCGCCACTGCTCAGCGTCTGCACATCCCTACATGGCTAAAACAGCAATGGCCTACAAGGAAAAAATGAAGGAGCTGTCCATGCTGTCACTGATCTGCTCTTGCTTTTACCCGGAACCTCGCAACATCAACATCTATACTTATGATGATATGGAAGTGAAGCAAATCAACAAACGTGCCTCTGGCCAGCTTTTGAGCTGATCTTGAAGCCACCATCTCCTATCTCAGAGCCCCACGAACTTTAGCTTCTCCAAAGAAGAAAGACTGTCTCTGGAGGAGATCCAGAAGAAACTGGAGGCTGCAGAGGAAAGAAGAAAGTCTCAGGAGGCCAGGTGCTGAAACAATTGGCAGAGAAGAGGGAACACGAGCGAGAAGTCCTTCAGAAGGCTTTGGAGGAGAACAACAACTTCAGCAAGATGGCGGAGGAAAAGCTGATCCTGAAATGGAACAAATTAAGGAAAACCGTGAGGCTAATCTAGCTGCTATTATTGAACGTCTGCAGGAAAAGGAGAGGCATGCTGCGGAGGTGCGCAGGAACAAGGAACTCCAGGTTGAACTCTGGCTGAAGCAAGGGAGGGTCTGGCACGCCCACAATAGTAAATCCCCCTGCCTATATTATAATGGATCATGCGATATCAGGATGGGGAATGTATGACATGGTTTAAAAAGAACTCATTATAAAAAAAAAAAAAAACAGAATCAAAAATTTAAAAAAATCAATGCGGTCTCTTTGCAGAATGTTTTGCTTGATGTTTAAAAAATACCTTGGATCTTATTTTGTAAATACTTACATTTTTGTTAAAAAATACAAGTATTGCATTATGCAAGTTATTTCATATCTTACATGTCCTGTAACAGGCTTTTGATGTTGTGTCTTTCCACTCAAATGAATTTGCTAGGTCTGTTCTTTTTGAAGCTCCCCATGTCTAACTCCATTCCAAAAGAAAAATGAGGTCAGTAGACAGTCTATGGTGCTAGAAACCCACCATTGCCTAATGACCTAGAAGGCTTTGTTATCTCTGAGCTTGACTAAGACCATACCTAGATCACAGGTATTATGACTCCACATGAACCTTCACATTTGTTCGCTCATAATCTACTTACTGCCTAAAAACTACAAAACCAGGCTAAGAAACACCACCAGTTAGAGCATTTACTTCTGCTTCTCCTGGATTATGTGCTACAAATGTGCTTTGACTTTAGAAAGGGATGGATGAGAAGACAGATCTGAGACCAATCTGGGTAGAAGCAAAAAGTTGAACCTTTGAAAGTGCTGAACACAAATCCAAATTCGAATGGTTCAAGTAGCCGTGAAATCGCTCTTCATAAAGTGGGCTTAATTCTCTAGTTTAAGTTCTTTTGATGGAATGAATTAATTAATGTGTCAGGTGGCTTATTTGTGGATGCCATGATTGATGATGTTCATTTTAAGCTCTTACCTATAGTACAAGTACATGATGCTACTGAATATTTTTCCACTTGGAAACTGTGAGCTGGTTGTTGCATTAAAACACACATACAAACAAAATCAAAAACACTGCGGACTTTCACTCAAGCTGGTCTTTCTTCCCCAGTGTAAGGCAATCCTGCCTACTAACAACACCAACAACAAAACACTCCATCTGTGAAGCTGACGCAGTTAAGGGGGCTAGGCAGGGCATTTGTGCCAACTAAGAATCACCAGATACCCAACATAAGTACCTATCGCAGTTTTGAAGTCGTTTCTCCCCAACTCCCAACTCCTGAAGGTTGCTGCCTGCATATTTACTCTTCATTAGTGCTATTTTCCTGTATGTCATTGTGAGCAAGCTGTGATTAATAAAGAATTGGAGTTCTGTG + 66435,0.643=98?7@8:21469::=:=?>;<<7224.1:5@?7(384%5?5;3@9@1B=@AC4@C6C7;67=192@B@@A2<;@8?<<872<6?2593:=<<8<529:1436542=2@7:5=*@;>:??;7>9=>7;<2?>??:5;65=:698837639/.55059C7?5;66B86;B;27=<538=(698>:8<>==/B?9$=?9@4924<6>4@2;<<<7<@406.:;97A8?8511A?6%8B@91848?5:>;,.359/?C:;>=(92+;;759=A;6:@18389@>?;B3,=;$=77788,<9?>==9>:C<2894;?A4?A=:=@48(.63:>>8>>745<6=29605389/,<8:@5B56;=>6:>;66?@;:<:G:BB=?7>9@:<9B>85>8)BF6/BCDCB=;/;>;BBEC:BE6:;>,B9:=92:*@=?A4A+?5B>C>??A&C5>:;9=5=13(=;CGDB>18=0=,>>@E=;:8&;+5;9>8:68D>:C@<>B8+965@:;?7;.>EEG:>08??7EB;E3=?)B9=>>2.BFB=CHCB2FA@BG=5AD?0;3EGAE=EBHJC3=?A7?D;=3/90;?B<@?;@=>DGBHCC8AHG*B>==.:J>HABBGA09AD?8?8CD1GFH=):B?D<)EFBE2?7=@AA?@DD=BB6,05,HIG:=F@B,==,DA.BI?BEEHJBFHIJI47E9@5DDDD2:A;D3G@=;D=4>H>E?FFD?>>DDC7AGBD4DB>6DIA<>DC859*>HCBC;HB;?B9BD97A5AE9>D8@98H=@@8<>CBBJFBEG9@GBDDGB1HBFCAJ9<@HAE>?DD<;8>4;>0A43:-<>-=7;=7=8@5F;=+43ACBB@E@FD0>9<>?;3B<66IDA@D9G9EF?BBG@-FGCFA<;;8BC?/ABH8C8D<1A@=@7=G:GCCBA'6B?./:<.A63:AA/FBDDGC+>H?=I8DBGGGFCA0D=EC=8B2A6EEE6>G4=C;IB@DGIED@@?HF;D@5A?<:FDGJDEIHEED<&;/0<@)F=@>AGD4=2EF@?=>F+FGHIA90<>EGD7@:;1>2:CGDFHC?/=>9@A45@C=CCAGC,@;FB@AE6DD6?7A>?;B@;7:24;DAADI@?F.B>C?F:A8AD6B<>@B?DDD<@D=AH:BF=HAEFE94??HH8BC@?DJ<@;DG?F@HH<D/:=<$FGCCF:CE>;@B@*(91+78B=);=;;E9;FBE;76HBB1>=9A=ED=7:AJJ)=GBG?B>6;+<9FB:8;@GC/=4C?BIDBDBA=AC;=GCCDC?A/BAIGG9>@;-;98;@5B6AAGG6B8AEDA7>IDH2C9AFB@B,@G??HE;?8H>;:AF;EDB<;.GFAIG @rCer/411/1871_59_CCS GCATCGCGCACTGGGGCTCCGGGCGGCTGGGACCGGCCTGGGGTAGCTGCGCAGCAGGTGGGTCGGTCCCGGGGCCGCAGCGCGGGGGTCAGGGAACGACCCCGTCGGGGCAGACGGTCTGTGGGTTCTGGCACCATCTGAGCCCCCTGGCAATCCCTGGCACCTCTGCTTTGGAGCCACCTTGTCCCCGGTTAGACAGTGTCGCATTTTCCAGTGCCGTTTTGGAAAGATGCTGCCTTTGGAGAAGGCATTTGCCTCCCCCAGGAGCTCCCCAACCCCCCTGGATCTGCCCACGCCAGGGTCAGCAGCCGGAGCCCAGCAGGAAGAACCCGAGACCATCCCTGAGAGGACCCCTGCTGACCTGGAGTTCTCCCGCCTGCGTTTCCGAGAATTTGTCTACCAGGAGGCTGCCGGGCCCCACCAGACCCTGGCCCGCCTGCATGAGCTGTGCCGCCAGTGGCTGATGCCTGAGGCGCGCTCCAAGGAGCAGATGCTGGAGCTGCTGGTGCTGGAGCAGTTCCTGGGCATTCTGCCTGATAAGGTCCGGCCCTGGGTGGTGGCACAGTACCCTGAGAGCTGCAAGAAGGCAGCCTCCCTGGTGGAGGGCCTCGCTGATGTCCTGGACGAGCCAGGGATGCTGCTGGGCTCCCCTGCGGGCTCATCCTCAATTCTTAGTGATGGAGTGTACGAGAGGCACATGGACCCTCTGCTGCTACCAGGCGAGTTCGAGAGCCCCAGCCAGGCCCGCGGAGCTGGGGAGATCCCAGCACCTTCTGAGACACGTGAGTGCCCAGCCAGCCTGGCAGCCTCTGCTGGGCCTTAGGTGGTGGGCAGAGGCCTGTGGTTGGGAGAGGGCAGGAGAGCAGCCAGGGAGTCAGGGGCCCCATGGTCCACGCTATCATTGGGACATCCTCCTGTAGTTCTTCTGAATGTTAGACATTGTTTATTAAATTAGTCTTCAGAGATTATGCAGATAATCCATACTTGCCACAAATAGTGAAAAAGCATCAATACATAAAGAAAAGAATCTCCCAACCCCCCACCATGCACCCTCTGAAAATAAAGGGTCTCAAGTGTCCTGATGCAAGTCCCTCATGTCTCCCTGCACATCACACATGCACATTCAGGGCCTGGGGTCGGGCTCCCTGTGTATGGTGTGCTGTGTCTGAGTGCTTGCTGTTCAGATGGGGTGGGTCCTCCAGGCTGTGGTTGGGTCTGGTTCTTTAGTTGCCCAGCATCACGTGCTTAGCCCATCTCCATCCTAGAGGTGGACTCTCTGCCCCTTGGAGTGAAGCTGCCAGACACCTCCTGACTTGTGTGCCCCATATGTGAGGCTCTGGGCACTGTGGGTGGGCTCCTCAGGACCGCTGGGCAAATGGTGTGTGAGTTCGACATTTCACATAAAATAGAAACTTCCATGTGGTTTTCCAGAAGTTTTGTGGCTGTTCATTACCAGCATGGGAGGCGACCACTGGCCTGGATACAGCCCAGCACTATGTGGTGTTGCTTTTTAGGATTTCCACGAAGGCCAGGCACGGTGCCTCATGCCTGTAATCGCAGCACTTTGGGAGGGCAAGGCAGGCAGATCACTTGAGCCCAGGCATTCGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTACAAAAAATACAAAAATTAGCCGGGTGTGCACTTGTAGTCCCACCTACTTGGGAGGCTAAGGTGCGAGGATCGCTTGAGTCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTTTAAAAAACAAAC + 2D?HCHIICIFFGAI,DCIFGI=IJ@BEHE:;F:E@JFHHGI>G8AB0>ABFD=?6?>CEH8DEE@?HI@C?J8JHHIHHHIGJHHFBICDHH?F9EH?EDF@IHGGDF7IED?6HFGIEDCF@;IAD>JHFHFHE?B?FF5B=A?+BC;=C8@=G6?FCEFJA>>EGEBFCFFEGJDIHDF>IFCAE2@6FCDDA?D?56C6EADBBC6HDEDGEC.GG7BCG=IBEAGFFAECCBA@<==>?87AAEFCIFIHHF?@EFFD3J=GIBJJHC@DHHBE:AF?@ACAFD3;6GCH?ACAJDD>-FE?4:<3>GCGGFHI?GGFIFEC==C?IG@H?IHCD:?@=>CDGCHHG;EHH9EGHH6E8@FDIGCE7JGGAFG>E>BGEDD@F>>0?7FDCEGDFDF=CFHG@FB@CJ,CI7JHBEJA>?G/FHEJJDGJECID?H;JIDIGFFIFJIF;H7FECIABHHA@@7DG8E2G+C:EHKJIKJIHHKJB6?EKCCKHJK:CGEFBIIEJKG?@HIFKEBGIGHGFKCKDJ@@BBHB@CDEIGGKJJJDK?AJJJKJKIF0GJGJJIJKJJHEHCI?CDDGFFEEIJGFKEKJGIHJCJHKCIKIJJJKBHDEHJKKKK5JJGHEG6IIJGGHJ>JKKJHJI=AEFFIFAAJKI3KGKKAF@GI;GFEKEIDC?JJKGGJKGFJKKKIJF@JJAJGHJJ?DHHBCKKI:JJKBEKCIE>GIIIJCKHHH?KI=CGAKIKGIJH:HJJJJAIKCKIJII6IJ=@>JD;IHGHIBHEIFIGIIKI0GIGEGH/;GE1GKBKIIGIHIIJKKKIGJ:CFKKIFKH2EAHFGDGIFH>?GKHKKKIHK=JD>HKKGDEJKIH1FIJKKHFIJJKKD7;HIIKIJ8JFGK66JKFCAHHH;HI7=;3.+6>2?<560*47;:88,4:6144%*$9<68/8.>6>?=193;8=8::1,32%=1189323=68->:26,7:95628:.::;99397*99499:75221%289'739::600,--1+42%473& @rCer/416/0_1500_CCS CTGTGGCTGCTGATCCTGGCCCGCGATCACAGCGCCACCGGCCGCGCGCTACTGCACCTCGCCCGCAGCTGCCAGTCTCCCGCTCGTAACGCCAGGCCTTGCCCCTGGCCGCTTCTGCGCGCCGCAGACCCATCGGACGCAACCTTATTCGCAACCCTGCGCCAAGAAGGCCTCCGAAAGTGGATGGTGCAGCACGGTGGGGACGGCTGGGTGGTGGAGGAAAACAGGACAACCGTGCCTGGCCCTTCTCAGACGTGCTTCGTGACCTCATTCAGCTGGTGTCGCAAGAAGCAGGTCTTGGACCTAGAGGAGGAGGGTCTGTGGCCAGAACTGCTGGATAGTGCAGGATTGAGATTTGTGTCTCTGACTGTGGGGAGCCCGACACGACAGTGGCTGTATGTATAGACTACTTGTCCAACTTCTAGACGCCAACCGACTGTTCTAGATAAATTCTCTGCTGTGCCTGATCCCATCCACAGTGGAACAACAATGCTGCCTTCACGTCACCCACGTGTTCTCCAACATCAAGATGGGCATCCGCTTTGTGTCTTTCGAACACTGGGGCCAGGACACACAGTTCTGGGCTGGCCACTATGGAGCCCGTGTGACCAACTCCAGTGTGATCGTGCGAGTCCATCTGTCCTAGTCCAGGACTATCCTTCTTGCAAGACAGCCTGACTGTGCCTTCCAGGGCCCGGACCATTGGCTGGGACTCACCATTAACCAATTGACCACTTGTACTCCCTGGCATACTGAGAATTCCTGGGTCCAATCAAAGGCCCTGACGGGCCCCGTCTTCAGGTTCTAGAAACTACCAGAAGAAGCTTCTTCCATCTTATCTACCTACTGTAGCTGCTGCTTTGGGGGGGCCTACTCTACTGAGGGAACCCACAGGTGAGCCTGGGGAACGCCCATCTTGGAGAAGAATTCTCGCCCTCCCCTTCTTCTCTTCCACCCAAAACCCTCCGATCAGCCCCAGACCCCTCTGTCCCATCCCTCCCCTCCCCGCCATTGACCTCTTGTCTCCTATTGTTTCTGCCATAGGGACTTCTTTGGTCCCTTCAGAGAAGCCCTCTACTCGTCTCTGAACTTAGAGCCTCATCCTTAGGGCTCAGAAAGTCCTAGCCCTAAGGGTGCGAACCTCACCTCCTGGGCTTCCGAGCTGCAGGGCTGGGACCAGGTCATGCAGCTGAAAATCCACGTTAAAAAAAAAAAGTCTGGGCCGAGCACAGTGCCTCATGCCTGTAATCCCAGCATTTTGGGAGGCCAGGGCAGGCGGATCGCCTGAGGTCAGGAGTTCGGACCAGCCTGGCCAACGTGGTGAAGCCTCGTCTCTACTAAAAATCCAAAAAATTAGCCGGGTATGATGGTGGGCGCCTGTGATTTCCAGCTACTCAGGAGGCTGATGTAGGAGAGTCGCTTGAGCCTGGGGGGCGGGGGCTGCGGTGAGCCGGGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGT + S,--1211.++(&+$.).1%//-1226500254656/.3-3)036555.*,0'%,*)./-4265264/14&),-4-//042652121/6*2265,226)1##350*.2*555/40212213%-13/450664(1%315,522031/0&0-...,',5-*0$-1065,4(0(2/.02266665624&0'25+2265,31*1241/$-03/66.&2-'4)36)34442)0*)*-)..+,%-/%3&02130105501512,$214040*5/4.464-0(/)024-300%.3-400.*33/)5,0.-44//0%+1.51*34/2/0+)4(5'()540420/4021++)&*)0/-1001%166233150/)0002*/-30/*0135144100.4+10+40./42+//.&-+04541+75/*4(5299::4.367+2+849+5:25.645-+40/366:926,857:9039/3/5%7749+9554/*28,1345)7:90$360:7;:6/95,3&259+772,78:::5:::::7:18,-69854,838(7352346,7825396241,556-:37737602764-5/-(96173:/68.9:754:6)97443564-91838:;:0)-46.099.35773-48645-33,7412(468'/05394009760:651515:707;8.34:981-72:,33+:8/60$613:528/95:.764/7902:95;%4'71:4:4-.6367:91.$*-.77-88:9295664-2.7'47*775*93:9729:69,::.:9:*52$5/-35/-822(4.69526&38582451/-::09:41=>;?5>:8:%85-+087>34<<;9=>-8<996=,==';<<;869?3==<=02=7;.*>;6;+=9;64:?=7<74:7*2-92952,77247.7398;<>38>2>2<9<15>;(;:1$#0+)9288<)>5&78/:=;4??86=><4)7<*==96:3%65378:;3%3797/9=5(<<99$34488?52:<=5?>1)=>:<<:<>92?=+=932<&88=>-::=07<>==?4>9:82;1=69??;897=9<69<,<>97>909=:<:=?77==4:3=:=5;>526944/3??,55<>=8<6.6=<>::>>>=274???23;93;6;%988<<;<:876<:=8;=4=;6*8:;=99:9?><=<=3<>?>4:,&53039>2???+7194>7=8(24:7.29,;;96489>>82=8:38:86:?;$362>28.423?'*+:7312::>9?8/832<:8:::28:$;958;9:(:<<;9:;8<:?3??1/21507;79?;:>7:<;8;77==4<><9:79:;9837225:;2;<938>8==99:5>:?=562;<+9;<786,:89:788=2688>>7;8>>78;9?>>??;2844;=;36<(45'34<2<7=>99<998;<6;84< @rCer/417/1691_58_CCS ATGGGGCAGTTGTGCAGCAGAGGAGACTGCAGACTTCGGTGAGGAAACGGTATTTCATGTCTCAGGGAGTAGATTGTGCAGTTACAGCTTTTCTTTGGTATGCATAATTAATAATGGAGCTGCAAAGCAGATCGTGACAAGAGATGGACGGTCAGAAGAAATTGGAGGACAAGGTTGTTGACCTCTCTACTGGAGAGACATGAGAAGACTGGAGTGGTGTTTGGTGCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGTGTAACAGCCTACATTGCCTTGGCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAGGGTGTGATCCAAGCTATCCAGAAATCAGTGAAGGCCACCATTCAGGGCATATCTGGAATCTGAAGTTGCGATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTAGTTGATTCTCTGAAGTTGCAGTGTTGATTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACGCTACTGATTTTGGCTCTCATTTCACTCTCAGTGTTCCTGTTATTTATGAACGGATCAGGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAATCCAAGCGAAAATCCCTGGATTGAAGCGCAAAGCTGAATGAAAACACCCAAAATAATTACTAGGAGTTCATCTTTAAAGGGGTATTCATTTGTATATGGGGAGGTCAGGAAGAACGAACCTTGACATTGCAGTGCAGTTTCACAGATCGTTGTTAATCTTTATTTTAGCCATGCACTGTTGTGAGGAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTAAGTATTGTAAGCTGCTATGTATGGATTTAACCGTAATCATATCTTTTCCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTACTTTGTTGCAGGTAGTCTTGCTGCATCTTGGCAAGTTGCAGAGATGGTGGAGTTAGAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAATGTTTAGACGAGATCATACCAGTAAAGCAGGAATGGAAAATCTTGCTTTTCTGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGTAATATAGATTATATATATAGTGTTCACAAGCTTAGACCTTACCTTCCAGCCACCCACAGTGCTTGTATTTCAGAGTCATGGTTATACATGTATAGTTCCAAAGCACATAAGCTAGAAAAAGAAAATACATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATAATTTCATTGCACAGACTTCCTGTAGTTAATTTTGTCACAAATCAACTCTATGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGCAATATCAAACATTGTTATGCAAGAAATTACAAATGAAGATTATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAGCAAAGTATCAATAAAGCTTATAGAC 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@rCer/425/0_875_CCS CAGTGTTAATAGACCAGTGTGACAGATCACTTATCTTTGTGGATTGTGCTTAATACTGATTCAGTACTGATTTAATACCTGACTTCAAAACTGACATCTGTTGTCTGTGATAACACTTCTGTATTGTGTCTAACCACTTCTGTATTGTGTGGTCTTAACTACCTAAGGCGGCAGCGGCAGTGGACTCCTTCCTTAGGATGGGATCAACTCAATTCAACAAGATTTATAGACATTTACTATGTGCTAAGCATTTGGAAGACCAAGCTACAAAGATAGACATAGTTCCTGCCCTCCAGGCAGCAGAGGAGCACAAATACCAGGAATCTCTGATGGGTGTAAAGTGCGGTGGTGGCCACAGAAAATGACCATCATGGAGACCCTGTCAAAGTTCCGACCTGAGCCAAAGGGTATTCAGAAGTGGAGATGATTTTGGTCCCACTCATAGATGGGTGGCAAATCTAGGATTGTATAAAGCATATGAAAGTAGGGTGATCACCCCGAGGCAGAGGGCCAGCATTTGCAAAGGCACAGAGATAAGAGGAGCAGGGCAAAGAAAGGAGAGCAGGGAAGGTGTGGAGACGAATCTCAAAGCTAAGTAGTGGAAGCTGTGCACAGTGCTCACGCCTGTAATCCAGCACTTTGGGAGCCAAGGCTGAGGATCACTGGAGCCCAGGAGTTTTATATCAGCCTGGACAACATAGCAAGACCTTACCTCTGCTAAAAATTAAAAAAAAAAATTAGTTGGGTGTGGTGGGCATGCTGTGATCCAGCTACTCAGGAGGCTGAGGTGGGAGGATTGCTAGAGCCCAGGAAGCCAAGGTACAGTGAGCCGTGATCATGCTGCTGCACTCCAATCTGGTGACATGAGCCATGTC + F>5??.EAFD<;,'A<4BB<>F3?GGF9D:DJBIH%A>5>/JG.HBA;D=E(AGD9?FJDA?3H=BECII+JG(EIF+3.GG*=JA/JKGG;G=K=I@GJCKBJIA2ECGDBB$@6DKFAHBF1KGHG?5$:J6HE&5*(+?D20JKDJ?>8BH%5D@8;9F1F6B=H%KK:$>@>=(D73853*>A9FA=8HKKH*@9'H0K+BHKHF%I5AD1JG5E-HFHI7IBI8DH@HKKK/KKK'KH0KKHHEJFK?DD5#@@E3JD8KKKJHKAKK(KHGAH@KKF7A;J:C*IJCJK9KKKHIJJJ?KKK5H1IFIIG)KK6K?IAI.IJIJ?KK(KKHGHKJEFK?KEJ3K93JJCKKJ(JIJ+KK4KKE6>%H4KK@J)=)7;)G/>.B??KI@EI.KKEIHGKF9:6H9K7KIJGFEGJKJJE556C6HKK$JA8;AKB6KJHI83;KK/KI/);J9K+KDA'D8FFJ?KD(.KJF8KKK7KGI1KKIB61FIAF0K65GC/'I=;G@EI1KDE8K@JH8HFKEJK21HHIK75$EJIJFE>III9H<5EK&HECE?8JI1IC8KKIJI)IG'JH?>KE.K>HJKJIG)GIJ3K8K?7J;@-DFIGJIKGD>*@1FEJK>AEAI3HB:CGJGI@K*HC>:+GCIHD'?HIH9J>BFK= @rCer/428/0_347_CCS TATCTATACCTTTGTAACACAGTTGAGATGGGAACTGTTTGGGTTTAGGGCGTCTTAGAGTTGATTGGATGGAAAAAGACAGGAACTGGTGGGAGGTCAAGTGGGGAAGTTGGTGAATGTGGAATAACTTACCCTTGTGCCTCCACTTAAACCAGATGTGTTGCAGCTTTCCTTGACATGCAGGATCTACTTTAATTCCACACTCTCATGAATAAATTGAATAAAAGGAGATGTTTTGGCACCTGACATAATTCTGCCAGGCTATATGACAGTAGGAAGGAATGATTTCCCTAACAAGCCAATGCACTGGTCTGACTTTATAAATTATTTAATAAAATGAACTTTAC + S))'-),)'))'(#"!"#+*++')(%#&(),+&'$'#+-($+,)-()()&$''%&&$%(($(#&#(#(($%&""&##$##'%)%'&&((#&)($'))+)-',((,+,,)'+(-,)'++-'+-(*'')')+)(.-(+%*)#*+)+''()%&(,-&*&##))*+**)'((.-()#$((%$&*&#$()*'')*',,%)',+.,,-)')))*-+(&$(&#(+-('&'$,'%#,*#$##%#%&+(**,+**%('(*#$()-,*+('%(''')')-+**$,.+-(-%(++,&(%',,*)-,)+)+,+(**,)'*)*+%)&++-*-*-(+)-,',.-**(&)*,(+((-'#)+) @rCer/429/2666_57_CCS ATGGGGGCGGGGACCCGGATGTGTGTGGCGGCGGCGGCCGAAGAGCTTGTGTGCGGAGCTGAGAGGCCTATGGATGAGGAGGACGCGGCGGCCCGGTTTGTTCTCATGAACAAGATGGATGACCTCAACCTGCACTACCGGTTTCTGAATTGGCGCCGGCGGATCCGGAGATTCGAGAGGTCCGAGCTTTCCGGTATCAGGAGAGGTTCAAACATATCCTTGTAGATGGAGATACTTTAAGTTACCATGGAAACTCTGGTGAAGTTGGCTGCTACGTGGCTTCTCGACCCCTGACCAAGGACAGCAATTATTTTGAGGTGTCTATTGTGGACAGTGGAGTCCGGGGCACCATTGCTGTGGGCTGGTCCCTCAGTACTACAGCTTGGATCACCAGCCTGGCTGGTTGCCTGACTCTGTAGCCTACCATGCTGATGATGGCAAGCTGTACAATGGCCGAGCCAAGGGCCGCCAGTTTGGGTCAAAGTGCAACTCCGGGACCGGATTGGCTGTGGCATTGAGCCTGTGTCGTTTGATGTGCAGACTGCCCAGATCTTCTTCACCAAAAATGGGAAGCGGGTGGGCTCTACCATCATGCCCATGTCCCCAGATGGACTGTTCCCAGCAGTGGGCATGCACTCCCTGGGTGAGGAGGTGCGGCTGCACCTCAACGCTGAGCTGGGCCGTGAGGACGACAGCGTCATGATGGTGGACAGTTACGAGGACGAATGGGGCCGGCTACATGATGTCAGAGTCTGTGGACTCTGCTGGAGTACTTAGGGAAGGGCAAAAGCATCGTGGATGTGGGGCTGGCCCAGGCCCGGCACCCACTCAGCACCCGCAGCCACTACTTCGAGGTGGAGATCGTGGACCCTGGAGAGAAATGCTACATTGCTCTGGGGCTGGCACGGAAGGACTATCCCAAGAACAGGCACCCTGGCTGGAGCAGAGGGTCCGTGGCTTATCATGCAGACGATGGAAGATCTTCCATGGCAGCGGTGTGGGGGACCCCTTTGGGCCACGCTGTTACAAAGGGGACATCATGGGCTGTGGAATCATGTTCCCCCGGGACTACATTTTGGACAGTGAGGGGGACAGTGATGACAGTTGTGACACAGTGATCCTGTCTCCGACTGCCCGGGCTGTCCGGAATGTGCGGAATGTCATGTACCTGCACCAGGAAGGGGAAGAGGAAGAGGAGGAAGAGGAAGAGGAAGAGGATGGGAAGAGATAGAGCCGGAGCATGAGGGCAGGAAGGTGGTGGTTTTCTTCACTCGGAATGGCAAGATCATTGGGAAAAAAGGATGCTGTTGTTCCTTCTGGAGGCTTCTTCCCCACCATTGGAATGCTGAGCTGCGGGGAGAAAGTCAAAGTAGATCTGCACCCCTTGAGTGGCTAGGGCCTCCCCTCCAGACCTGCTTCTTCTCCCTGCCCACCCTCTGCTGGGCCAGGCACCCAGTTCCTGACTTCCCAGAGGATTCATTTACCCAGCAGGCCCCTGGAGGTGTGTAGTCACTCTGCCCCCACTGGCTCAGGCCCGTCACGCTTCTCTGTGCCCACGTTTCTGACCTGGTGCTGCCACTGTTGTCAGTCCCTGGGCCTGAGTCCCTGGTTGGACAGGAATGGATCCAAAGAATGGTGTTGGTATGTGGGTGGTCCCACTCGCTTCGGTCGGTGGGCTTCTGGATCCCCCTTTACTTCACTGGCCCCATGTGGGTGGAGAAGCGTGAGCACCCTATCTCAGCTGCTATTTAGGCATGATGCTTTGTAGAGGTGGAGTAGACAGCCCCTCCCCTACTCACCATGGTATTTCTCCTTGAATTCCTCTTTCTTGTTTCTTTCCTGGTTGTGTGAACCAGTTGCTGCTGTCATACCCCTGGCAGGGCCAGGGGACCTCTCTTTGGTCATCTCTGTCCTTTCACTAGCTGCTGCCCCAGAAGACTCCTCTAGGCTCTCCATTCTTTCCCTTGAGAGCTGGCTCCCCACCCCAGCCTGCTCAGGCACCACAGAGAATCTGCATCTCTGGCTCCCCATAACCTGGACCCACATAGGTGGGTGCCTGTTGCATGTTTAAGAGACAGGGGCTGTGAGTGACAGGGCACTAGGACTTCGCTCCTTTTCCCTTCCATCCTTCTTTGCCAGTGCCACCCATGTCCCTAACTCCCAGGTACTGGGGCTGAGGCTCTGGGGCCTGTCTCCCTGTCAGCGTGAGGGCAACACCCCAGAGCCTCAGCCGAGCAAGCCCAGAGGGGCAGCGTGGCCTCTCCCTCCCTTTTCCTGCCCCGTCCCATGCCTCAGCTTGCTGCTTGTGCCAGTTGCTGTTTCGCTCAGTGTTTGATTCTAGCACTTACATGTGTCGTCCCCACCGAGCCCTCTATCTCCTAATCCCTCAACCCTGACCCCCTCCCCATAACAGTGACTTCTCCATGGAGGAAGAGGGAGCAGGAGCTGTTGGTCTTGGTTTGCACAGAGCGGTAGGGCTGTGGGGAAAGCGGGTGAGCTGTTGTGCTGCTGGGCCTCCCTTTGGCCCTCGCTTCCTGCCCTATGATGTATGAAATGTATGTACAGACCAGAGATGTTTATACAGCCATAAAGATGGAGTTTCCGTATTT + 939965,5653&77.*--//45+2/7/1961:5056-=6:=6;8<==982744>=713>:><388/<-/9/57861,531;;6+/277=:86;*;;860463:415:6;.8;958;;51.=6=<9=>6:0=<9;1-5:2<1:>11<;35%+84815241897379357=;965376497:7<-77=:58(32:.886:446=5=>377920)0067:?=<:3271/761.;448)<5;7,,6292>85;38(400==84558?7<=:;:<<9/99966=7931.4421)989;9<+403142:7003.65322:0<<=0492631./%69=47?8=4086;8$2964545/65941+2+3::;9=9:3;==8=>:8905>/99<492:<2>;23+:;<97/831.:3=:9:/58-478>74?:56727;=;:89/83<9.;/;85<056:<7.08=:1661699.67;676243225)5<6;8>?9=8547<;9;986:13<6885573=79/42/5;)::=4968;<38=:=;?77=2<:=22743+;<1-7,9<>01:07191626?;;7:1509;-78/59=<0:>;==<,989;1=:55<:66/=8667,0=>;8><7<=2694=?5<>/0776*47=8217<23/;2;:.=2==:7-9*<4/)486770409669502874++18.7885>9>1*3-*37=:69;<>,>745/56<7;6<8;>=;<38>:3;8:%79=8&9<=:059:395/29;2;946.:66718;;89.7796775,<6>2;?63<373,91:::58.345:6329;0=;8=>6435:=;891,5%8<34<8;:8*8+;>>3=;5430055+:9159=;:89<8/:5/1'3:?957>;2=9=50;<<978&?29?<<<:2588947?=8::.'/>:=:9;+98*9<<495*479=89>:3>>5626$1/8:<>?6=9;6=897988355898=>,;<>;+=817609,+=>758:943;89869/2983;::==1753*434*<3%/6?<;<=:(>?.<2.2=;::7'874>9>=<527<=,4/48733462742;33-89:899>65<2<93;21074>=8;8>4/8:,9::0/%,%:59465>307(6;:65:<46?;=:>68-=98;9568'31>;7&?;<>>:>?<:389:7:212;27,3858-680#02-5832;7:.2);575991568<*>:;:9-9705)39.=9?;5<29:99:956.5=6:7533==577;9041267%<7:44:86=88;2;6<<>:=84:660)/>5:??28:<43.5365736;878=>;9;9:/999>6<99<;(=80/:;;<;;985=-=8=84)=3:>7/72:9;<-4/0<;==(9=743:=:1,-1%;8>;3;88=3108$78<441>887++,74,5;699976=:719646=5<662-4;=661&35*066.<878<<<=>>9*57-772<66::28?;89>:6;09:89=405::8.8:/;8;2:63377388&:4/=3;99:;7272;88;9>:=:797,1<=067234:?6<;248<5769987;:9:/>7<2<9:47;9==:53:?==?7;?68:71>=;2<48=9332-326'5=8=8?;:88368279<9/83/6:7<9<6946:66-9?69<86=69;8;7777989.05/6:95982=<>38$4.<503/749=?<=:>:69>61=-;2;=?88:0>.6:9=579/2:8&2?<2308:9:59<=<;?:?=8=88858=<1<7<:26144%8<1=5,5+?;:::9+46,8=7489(:93:5898:9<894882><;9;>:89:4:78>578275:2/>;8<0/:(+.641+99,9<8316(3159<24;;=0/347:,253;,8.72,8=;<:4)2583<;3714553935728:1<708=69:8)6:6$;583(1696::2954554425:;85221/566.40(/-20522-/2/%,-.32,%'+446/+2440/4654$//4-2(4-.20&44(.).10)3/4-563,32*32(053565/+.6622.56/1152,04,424+(%..30102(530//43+40.*03,+.&1255/..'.41664/1%,.032)0+/,0%53.+--152062562,565556.1156630'+'3.-01,,55%)52-0*.23/-&0024)135223.364/)-)11/.('(-4,)45/.(1044'412%//56351*42512/053531/4602653012-653566301113*5462/23/-552665+20.&,2$.05421//2/14)41554*015220+.010341.+,*611156/41.24().4/564666023.,05+*0-.*+34.3&.05502055652(11#215/*+062.3520*,1656416635,/20(6656166415633.203/55)521/55033(*660532104/22+55615442032/)(5655153.%*55*1.154*/661546554/* @rCer/430/1678_60_CCS ATGGGCTTATGCTCATTAATCGCTGACTCTTTTCAACAAATCACAAAGACATTGGAACCCTGTATTTACTGTTTGGTGCATGAGCTGGAATCATAGGCACTGCCCTGAGCCTCCTTATTCGAGCTGAACTGGGTCAACCCGGCAGCCTACTAGGCAACGACCACATCTATAACGTTATTGTAACGGCCCATGCATTTGTTATAATTTTCTTTACAGTTATACCCATCATAATTGGGGGGTTCGGGAATTGACTGGTGCCCCTAATAATCGGCGCCCCCGACATAGCATTTCCCCGTCTAAATAATATGAGCTTCTGACTCCTCCCCCCTTCTTTCCTGCTACTGATAGCATCCGCCGTGGTAGAAGCTGGCGCCGGAACAGGCTGAACGGTGTATCCACCCCTGGCAGGAAACTTCTCCCACCCAGGAGCTTCCGTAGACTTAGTCATCTTCTCTCTCCACCTAGCAGGTATTTCTTCTATCTTAGGAGCCATCAACTTCATTACCACCATCATCAACATAAAACCCCCCGCAATATCCCAATACCAAACCCCTTTATTTGTCTGATCAATCTTAATCACAGCAATCCTCCTACTCCTCTCTCTACCAGTCCTAGCCGCTGGCATTACCATGCTACTAACAGATCGCAACCTCAATACCACTTTCTTTGACCCCGTTGGGGGGGGGGAGATCCTATCCTATATCAACACCTATTTTGATTCTTCGGTCACCCCGAAGTCTACATCCTTATTCTTCCCGGCTTCGGAATGATCTCCCACATTGTAGCTTACTACTCTGGAAAAAAAGAACCATTTGGGTATATGGGCATAGTTTGGGCCATAATATCAATTGGATTTTTAGGTTTTATTGTATGAGCCCACCACATGTTCACAGTCGGCATAGATGTCGACACACGAGCCTACTTCACTTCCGCCACTATAATCATTGCAATCCCCACCGGTGTGAAAGTTTTTAGCTGGCTTGCTACACTTCATGGAGGCAACATTAAATGATCCCCAGCAATACTTTGAGCCCTAGGCTTTATCTTCCTATTTACTGTAGGTGGTCTAACCGGCATCATCTTGGCAAACTCATCCCTAGATATCGTACTACACGATACATACTACGTTGTCGCCCACTTTCATTATGTTCTGTCAATAGGAGCTGTATTCGCCATTATAGGGGGCTTTATACACTGATTTCCTTTATTCTCAGGCTACACACTGAACCAAACCTGTGCCAAAGCCCACTTCATCATTATATTCGTAGGCGTAAATTTAACTTTCTTTCCACAGCACTTCCTAGGTCTGTCCGGAATACCCCGACGCTACTCCGATTATCCCGATGCCTACACCACATGAAACACCCTGTCATCTATAGGCTCCTTCATCTCACTAGTAGCAGTAATTTTAATAATCTACATGATCTGAGAGGCCTTTGCTTCAAAACGTAAAGTACTACTAGTTGAACAACCCCTTACTAACCTAGAGTGACTAAATGGCTGCCCCCACCTTATCACACATTCGAAGAACCAGCCTACATTAAACTAGTTGAAAAAGGAGGGAGTCGAACCCCCTAAAACTGGTTTCAAGCCAGTCTCATAGCCCCTATAACTTTTT + KJKJ*CEFJGJ?CKKKJI9KEJJJKJKKKJKJ2KKKKKK;JK@IIK7KKKIKKKCKEIIFKKIGDJ=JIKKKIBKBJ6JKIHIKKKKKKKKJHKKKKKKKKKKK@K;KJHIKKKKKKKJKKKKKKJKFJJKKGJKK>EGHJHKICKHKKKKKKJK?FKKGKIKKKKK*KEKKKEKKKKIIIKKKKEEKJK@KJK4KKKKKKKKBIFKKKKKFKK2KKCJKKIKK6KKJKKKK/KKKHKKKFKKKKKKKKKKKKKJKKKKJKKKKKKKJKIKKDKIKKKKKKKKKKKKKKKKKIKKKKKKKKKKKKKKKKJKFAKKHJKKKKJKKJKKKKKKKKKKKEKKKKK>KJJ>AC9KKKKGKKKKKIKK3JIE@KKKDKJKIJKKHKK6K>JKKJIJKKKGIKGJKKKKK@KKKKKKJKKKKKHKKKKKKIKKKKKKKKKJKKKKKKKKKDKKJJKHKKKKJKHJDIJK?KIFKKKKKKKKKKBKKKKKKKKKKKKG7>6KKIKKKI8JKFKIIJKKKK@KKKKK/GHKKKKKKKJ9KCJ@KKKJKKKKJK3KKKKKKIKK@KKKKKKK&KKKKKKKKKKJKKKKKKKKJ>JKKKKJJKBKEKKKJIJKKKFKK?KKAEKKKIKIKJKKKKKKKKKKKKKKKKIKKKKK6KKKKJKJKKDKKKKKJKJJFGKIHKKKGKKKFKKKGKKDKKJK8KKKKIKKKGKKKKKKIJ@KKKKJKKKJKKKKKDGKHKJKKKKK=KKF47JKKKKIDKKKCKCKKJKKKKKKKKKKKKKKKKKHHKDGHKKEKKKKEKKKKKHKKK:HKKCIKKKAKAJJIKKKKKKKJKJIKKAKKJKKKKKEKKKIKKKGKKJKKKKKKKKKKKKKJKKJKGKKIKKKK2KKKKKJIKCKEBKKHKKKKIKKKKKKKKKKKJKKKKKKKBKKFK@KKKKKEKKKKKKDKJKKKHKKKKJHKKJKKKKKJKFKKJKKKGJHKKKKJKKKKKJ@KKKKIJKKJKJKKJKKKHKKKK=KKKKGDBDKKKKKJGIJ>KK@KKGKGB2KKKKKKKKJJJKKKKKKKKKKCKKEKKKKKIK+KJDKJJKKHKKKKKJKKKKKKJKKKIKKKKKKKKKD9JKKKKIKKKKKAKKKKKKKKKKKKKKKKK3KKKK.KKKIKKKKKKKKKKKJJKKKKKKKKK8KKIJCKKKKK; @rCer/431/25_1859_CCS ATGGGGGACGCAAGATGGCGACGGCGACCATAGCTCTCCAGGTCAATGGCCAGCAAGGAGGGGGGTCCGAGCCGGCGGCGGCGGCGGCGGCAGTGGTGGCAGCGGGAGACAAATGGAAACCGCCACAGGCACAGACTCCATCAAGATGGAGAACGGGCAGAGCACAGCCGCCAAGCTGGGGCTGCCTCCCCTGACGCCTGAGCAGCAGGAGGCCCTTCAGAAGGCCAAGAAGTACGCCATGGAGCAGAGCATCAAGAGCGTGCTGGTGAAGCAGACCATCGCACACCAGCAGCAGCAGCTCACCAACCTGCAGATGGCAGCAGTGACAATGGGCTTTGGAGATCCTCTCTCACCTTTGCAATCGATGGCGGCTCAGCGGCAGCGGGCGCTGGCCATCATGTGCCGTGTCTACGTGGGCTCCATCTACTACGAGCTGGGGAGGACACCATCCGCCAGGCCTTTGCCCCCTTTGGTCCCATCAAGAGCATTGACATGTCCTGGGACTCTGTCACCATGAAGCACAAGGGTTTTGCCTTCGTGGAGTATGAGGTCCCTGAAGCTGCACAGCTGGCCTTGGAGCAGATGAACTCGGTGATGCTGGGGGCAGGAATATCAAGGTGGGCAGACCCAGCAACATAGGGCAGGCCCAGCCCATCATAGACCAGCTGGCTGAGGAGGCACGGGCCTTCAACCGCATCTACGTGGCCTCTGTGCACCAGGACCTCTCAGACGATGACATTAAGAGTGTGTTTGAGGCCTTTGGCAAGATCAAGTCTTGCACACTGGCCCGGGACCCCACAACTGGCAAGCACAAGGGCTATGGCTTCATTGAGTACGAGAAGGCCCAGTCGTCCCAAGATGCTGTGTCCTCCATGAACCTCTTTGATCTCGGTGGCCAGTACTTGCGGGTGGGCAAGGCCGTCACACCGCCCATGCCCCTACTCACACCGGCCACGCCTGGAGGCCTCCCACCTGCCGCTGCTGTGGCAGCTGCTGCAGCCACTGCCAAGATCACAGCTCAGGAAGCAGTGGCCGGAGCAGCAGTGTTGGGTACCCTGGGCACACCTGGACTGGTGTCCCCAGCACTGACCCTGGCCCAGCCCCTGGGGACTTTGCCCCAGGCTGTCATGGCTGCCCAGGCACCTGGAGTCATCACAGGTGTGACCCCAGCCCGTCCTCCTATTCCGGTCACCATCCCCTCAGTGGGAGTGGTGAACCCCATCCTGGCCAGCCCTCCGACGCTGGGTCTCCTGGAGCCCAAGAAGGAGAAGGAAGAAGAGGAGTTGTTTCCCGAGTCAGAGCGGCCAGAGATGCTGAGCGAGCAGGAGCACATGAGCATCTCGGGCAGCAGCGCCCGCCACATGGTGATGCAGAAGCTGCTCCGCAAACAGGAGTCCACAGTGATGGTTCTGCGCAACATGGTGGACCCCAAGGACATCGATGATGACCTGGAAGGGGAGGTGACAGAGGAGTGTGGCAAGTTCGGGGCCGTGAACCGCGTCATCATCTACCAAGAGAAACAAGGCGAGGAGGAAGATGCGGAAATCATTGTCAAGATCTTTGTGGAGTTTTCCATAGCCTCCGAGACTCATAAGGCCATCCAGGCCCTCAATGGGCGCTGGTTTGCTGGCCGCAAGGTGGTGGCTGAAGTGTACGACCAGGAGCGTTTTGATAACAGTGACCTCTCTGCGTGACATTGGCCCCTCTCCCTGGACTTGCACTTGTTCCTTGTTTCCTCTGGGTTTTATAGTGATACAGTGGTGTCCCCGGGGCCAGGCGCACTGTGCCCAGCCCGGCCTATAGTGCGGATAAAGGTGCGGATGCTGCTGGCCCT + KC,KKKKGKKI@IKDKIFIGHKJCK7KKKKKKKKKKKKKKDKKKKKKKJKJGKKDKKKKKJKKKK;CJJHJAGCKJEKFKEJKKKFKKJKIKKKKKHJGKKKIKKK&KKKDIKI7IIKKCKKKIKIDKJK@KKK)KKKJ>KKJKKAKKHKJJKKEKKKKKKKKJGKJCKK6KKHIFDJKEHIJKEJKFKKKKKFKEKH*KKKJDKKKKKKKJKIKFKHKJGKKIBHF=IKIJJ=KKJIFFKKKHIKFKKKKAKKKJJKKKKKFKGKKGKKIJKKJKKHKKKKKKKBKBKK;JHKKKGHJEIKKHJKCKKKJIJHKKKHJFJG>KKJKKHHJKKKJKKKKFKJKKKKEJIJ9KKKIKKIKGKKDKKIKKKKKBKKJKJKKKGKKKKKKEKKDKKKHKKKIJKKKKJKKAKIJKJKKGKKKKHJKKKKKKKFKKKJKJKKKJEKGKCKKIKJIJK6KKJKKK:KK?IKKIIKJKKKKKIHKKJIKKKIKKKJJJKKJKKKIKKJIKKKKKIEKK=KJJKJHKKHJIIIKGBIKKKK>KKKJKKKKKGKKKIJIJKKKKFKKKKKKKKKIKIIKKKKJKEKKKFKKKKIKKKKIHKKFKKKKKJKKK @rCer/433/25_2070_CCS ATGGGGGGGCGTGGCCCGGCCATGGAGTCCTACGACATCATCGCAACCAGCCCGTGGTCATCGACAACGGTTCGGGGTGATTAAAGCCGGCTTTGCAGGAGACCAGATTCCCAAATACTGTTTCCCAAACTATGTCGGACGGCCCAAGCACATGCGGGTGATGGCTGGAGCCCTGGAGGGGGACCTCTTCATCGGACCAAAAGCAGAGGAGCACCGGGGGCTGCTGACCATCCGCTACCCCATGGAGCACGGCGTGGTGCGAGACTGGAATGACATGGAGCGCATCTGGCAGTACGTCTACTCGAAGGACCAGCTGCAGACCTTTTCAGAGGAGCATCCTGTGCTCCTCACGGAGGCCCCGCTCAACCCAAGTAAGAACCGGGAGAAGGCGGCAGAGGTGTTCTTTGAGACCTTCAACGTGCCGGCGCTGTTCATCTCCATGCAGGCTGTGCTCAGTCTGTACGCAACGGGACGCACGACAGGAGTGGTTCTAGACTCGGGGGACGGGGTCACTCACGCCGTGCCCATCTATGAGGGCTTTGCCATGCCTCACTCCATCATGCGGGTGGACATTGCCGGCCGCGACGTCTCCCGCTACCTCCGACTCCTGCTGCGCAAGGAAGGGGTTGACTTCCATACCTCGGCTGAGTTTGAGGTTGTCCGGACAATCAAAGAGCGAGCCTGCTACCTGTCCATCAACCCGCAGAAGGATGAGGCTCTGGAGACGGAGAAGGTGCAGTACACGTTGCCAGACGGCAGCACGCTCGATGTGGGGCCTGCCCGATTCCGGGCCCCCGAGCTGCTGTTCCAGCCGGACCTTGTAGGGGATGAGAGTGAGGGGCTCCATGAGGTGCTGGCCTTCGCCATACACAAGTCCGACATGGACCTGCGCCGGACACTGTTCGCCAACATCGTGCTCTCCGGTGGCTCGACGCTTTTCAAAGGCTTCGGAGACCGATTACTCAGTGAAGTGAAGAAGCTTGCTCCAAAGGATGTCAAAATCAAGATCTCAGCCCCGCAGGAACGGCTGTACTCCACATGGATTGGTGGCTCCATACTGGCTTCGCTGGACACTTTTAAGAAGATGTGGGTGTCCAAAAAGGAGTATGAAGAGGATGGCTCCCGTGCTATTCATCGCAAAACTTTCTAGTGCCCGAGGAGGGCGGGGCACATTGGGAGAGGGGGAGGGAGGGCAGCCAGAGCCTTTAACCCTTTTTGGTCTGGGCTCGCATACTTGGCTTAGGGTCCCCTGCATGCCCTGAACCCCTGGGTGGGCGGCACGACAGTGCCCCCCTGCAGCCTTCCCCTCTACACACACACGACACGCACATATGAGTAACATTGAGCTGCATGGACAGGAGCCTTGAGCTGGCGCGTGGGAATTGAGCGCCACGTCGGGCTGTTCTGGGTATCCCCCCGGCAGGGCCAGCTAGGCCTGTGGTTCCCTGCTCTGACTCTCAGGGCTGCCTCCCCGAGCTCCAGGGCCAGAATGCCTGGATGCCTGTGTAGCCAGTTTGGGGAGTGGGCTGGAGGGGCGTCCAGCAGCTCCCGCTGGTGTGTCATCACGTCCATTGCCACCTCCTGTTCGTGACCCGACAGGGTGGCACAGCCCTTCCACACTCTGTCCTGTCTTCCTGGGTAGATGCCCTGGTGGAGGGCTCAGTACTGAATGGTCTTCCGTCCCCAGCAAGGGGGTGCAGCCCAGGGTCAGGCCCTTCGGAGCCAGGGCAGAGGTTGCAAGGTGGCCGGAGCTGCTGCACTCTCCCCTCGGAGCACTTCATCGACTTGCGCCTCCCTCTGCCCTTGGCACCCTGGGCGGGAAAGGGTTGATGCTCATCATTTATTGAAGAGAAGCCACTTAATGAGTCACACCTAAAAGGGGGTGGGGGACATTTTCTTCTCTCACCTCACCCAAGAAAGAGGTCGTCACTTTTGCTGTGGTCAGGGCTCCACTTCCCTCTGTCAGATATGTACAATAATTTAACACAGTTGCCTGAAAAAAAAACTTTTGTAAATCATTGTAGTAATAATTATGGACAAGGCCC + 57*247<92878-<4<4.;184:=?=6;-85232:;:67999;$2<06458;<3;;=><;>7<>=6=<,91;5&-2239895$686165<18<<99:16:8;2<385.4/886:?;<=88-<6/;8'98:977;98,9()6919;6<:9<989::(25/*75;?==*;7/9<=<;?51<=8>:=>1:/8+*8=5?627'7;;;=972/=699:=?/?951'8;90><9;<42?7835,7796718367624822,135:74035:88>88.3:<:83>79==9556609/*247>3;:=71;:>8(<782<>?3>==>85/5:1$2':8751::5;9;=97<.*=6:?=;+61??6A26,/;7@;6;C=@;>@,>@?AB;9?8><;;>>;=;>=>1?<5=?ACA?94649;7955>8A@;>=>>;7@:@B>@8=4=A@8=62945<=>:@=85779>>2>677><87=7A@B>8<3BC<>A=4:?=>::>3<8,547;=5795=6>;7:?=<./;57894=2762:,'83A4<8=1;;3=<2.8@:=<<>C4>C=897>A681:3243(2(',;-99=.:<3996;=0;?4B@=.@8/?8B7C>456???;40:04.4:;2=2;4>3=@=@86C726;=9??8<8>;:A9><>>A@7//95<8==;8<;/;8;;:55>=6;::?7<:8:76482;79777;=78519;75>8/68-;=8;359,5765899/>799(6984<6(73556;;>;<=87)54<;89>7>:7A:865:1:3:6<18147;7:2=8:;;9A=>A<7>=;>B:A=??92>-;$27;9:-<5;8>B@+9;;94;A>B@4.=/=?BA<93574<@>5*;A>@?B6:<;=>?B6@B;>3;<:3>A=6?CA7:@<=6AA6@<9@<>58:<,;7>0A>;??B54=>;6;8963?;3>B@5<8-0)78:A;>A=;AB8C<<;3=;?@:=7?7><>;>=9@>;-?@96>>?CBA9.?7=<7:?0>3;AAB:;:;<5;;3:9A566:3>>=)A6997;?>7>?;?7?B/B>;:499669779-88A@===4;@@6<4,>;>-=?644:A16=?@C8@7);;BA-BA>6::<@@79B;;BB4;(@?96:=>=A=1?>445AA>@7>=@8BA>67=/?@:1+8//*86=:B>>B<=B/<799>6ACC>7?9;/:;5,:===@?A;85AB>98:@>B@>6;?<<9C>;>;@283<9=A<:?=.@;B8=:.B<3B4=<>6=C=??54=;3@@A>B8@=?2><>;@+?:>==7<<04=>>?97;==@A=AAAB=A*=3@@BBA=<@?:??9@?;;<=CB<:?=>B;@:C<@:5=:942<;@:AB;1B?5<@57;=2C@;;&9>*>==:=;>=>B>A@>=-9897>2?7;<73561==89;:>;5@?0<859,=B9>4;@9<8539=;;<=17A>@?C<#AA37+>7/<>?>>>A;B=>,42:8><1??9>8<4:8AC>AC<9:=7;C:@>,14;=7399=7879:>/:6<788;;25.9,8:7>=9>;318<<1<>;;7+80?<3@@-?;5:?20>;A;:69A1;;@5=9;0:=;@84>;/47947@?=416;<@@<>:?65B-&>A?>A;)::8?14+52=;9:56;/A@.8<78?9<=19=?;7:>5.45548=988A;@0?;9@A<;@@;@A>CA2A@7*71/88/67=<;9;;?=>98@B.>@>=9A@?>C?7?8=A;=@>><;841=<7=@:;A@=<;>?6==;C>:==;=4>=589>6998=23-99616:9:5/<988;6?<1:505<56:81-6168=66:=>;:?6?-=9 @rCer/435/25_1823_CCS ATGGGGCCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGCTCCGCCGCCCGTTCACACCCGCCGCCAGCTCGCCATGGATGATGATATCGCCGCGCTCGTTGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCATATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATTCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCTGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTGGCCATCCAGGCTGTGCTGTCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACTGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTATGTCGCCCTAGACTTCGAGCAGGAGATGGCCACGGCGGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGTCATCACCATTGGCAACGAGCGGTTCCGCTGCCCTGAGGCTCTCTTCCAACCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGTAAAGACCTGTACGCCAACACAGTGCTGTCTGGTGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATTACTGCCCTGGCGCCCAGCACGATGAAGATCAGATCATTGCTCCTCCTGAGCGCAAGTACTCTGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCTGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTGTGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCTTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTTGGCTTGACTCAGGATTTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGTTCTTTTTTTTAATAGTCATTTCCAAATATGAGATGCATTGTTACAGGAAGTCCCTTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATAATGAGCCTTCATGCCCCCTCTTTTTGTCCCCCAACTTGAGATGTCTGAAGGCTTTTGGTCTCCCTGGGAGTGGGTAGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCT + ;8(98*#2854666'58=;4/&9827>2;6.484;9;9<=6:5;;:>4;>578;97391&77.88749353138894;83:5-/686082:9;881-5286-3486;9849972/7221598)6)696:9<5<:68664:6?7:4<88:7?66;1=9<<83:2)10>:>;50739>5=8==*99995=79<770:;;8<0<>>6/;986>04>=5:=1<404.'46223-55621:8;1:7*52-31313.022650-.%0.4:82595.732981487174594.7567144+4.958583343(489;57363).2(43:37-6:8977::919296;::96+.81-23'047:)8-5675-&89323216787:;35068915877.)/6689486964749694339.57844/6890773+407$+/6,4.+082471615.8;781069.30,35.579*416.(466041477270958793016/6::0:57:5,4353381,125203.64537619485.81:59981834-6/56:8;806/('043,.*658874/;;35714757,33*./.351226828.52'655+4643,7,$*5.8845674*20//464758'409-756/55152448:77/723106/69,23541041/2445/4930-241)04826:333397:/47:45(44,8859/+(%/56665)33;7761.9572368:9561214+880*.,459:527069:67,17;69854:9/50-6)20-/),/5+4215,10+51.1*,-53)6866,5:63974)0.$322192580,2/60.626/5:8:.908'3472::45/375669717*8668927/6134961786--/1465*1072*1-463878:26:23347$,202509;1+6646)1.330-/58866840867111475816:54353&($.*,%.1--5,.),+27428891:47:)5386(20..3.2(65464467.735437379456131586.7(.,0+205.9735855465368958/"1:5781:44747:897816052/6410+.'./27589557/976;9-+5(1/8438)2279::896;13669495692552572763984115/0138568644(7/3653478+695929.-185(27588329499,*:4831554334)45.5-+52-(2/3.%0-+''58.99:688580987355183015252)1(4551.6561356778,:764197/;91$,5$)8788797829987.99847$557767676624;229:9498336/$.11*69:8-12927996.2,9244556398/17/.0$4/175954416,-4420288429)/,52:95/03,306383946505*4877:97983;/%8676(0+,6:9:=::%767>0=<9=068;+61::<961?5623>;?>47:=&885+<:487:,<=<26;31>:><6576<897/1805:92:;5<.;;31&+2*/*$55:6869376;5+:=:528887=53:60786.;<5:8;5,<7(678774;376%98*(<=9;<<:7?>437:80=742==>5=1=:./02.478:8=;6?;:)89:8:>:79<556/.(83.967;259?;8=9;=?=;3<1&,2402 @rCer/436/22_582_CCS ATGGGCGAACCATTTCTAATCCTGAGGTGGTTATGAAACGACGGAGGCAACAAAAATTGGAAAAGAGAATGCAGGAATTTCGGAGCTCAGATGGGCGGCCTGATTCAGGTGGAACATTGAGAATTTATGCAGATAGTTTAAAACCAAATATTCCCTACAAGACAATCCTGCTGTCTACTACAGATCCTGCAGACTTTGCTGTGGCTGAAGCTTTAGAGAAGTATGGTCTGGAAAAAGAAAACCCTAAGGATTACTGCATCGCCCGGGTTATGCTTCCTCCTGGAGCCCAGCATTCTGATGAAAAGGGTGCTAAAGAAATCATTCTTGATGATGATGAGTGTCCTTTACAAATCTTCAGGGAATGGCCAAGTGACAAAGAAGAAAGAAGATTGGACATAGATGAGAAACCTCTAGTTGTACAATTGAATTGGAACAAAGATGACCGGGAAGGCAGATTTGTTCTTAAGAATGAGAATGACGCCATTCCTCCTAAGGCTCAAAGTAATGGACCTGAAAAGCAGGAAAAAGAAGGCGTTATCCAGAACTTCAAGAGAACTCTG + KK>KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK>KKKKKKKK?KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK3KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK @rCer/437/24_2177_CCS ATGGGGGGGACTCGCGTCGCGACCGCGGAGACGTGAAGCTCTCGAGGCTCCTCCCGCTCCGGGTCGGCGCTCTCCCTCGCTCTCCTCGCCCTCCGCCCCGGCCCCGGCCCCGCGCCCGCCATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAGCGCAATCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGGGTCATCTCGAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCACGGTCCTGGAATTGTTGGATAAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAAATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCATGTGGTGATGATCGAAAACAAACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATGCAACCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTATGAGATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATTGCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTGCTTAGAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCAGAAGGGGCTGAAAACTAAATCCATACAGGGTGTCATCCTTCTTTCCTTCAAGAAACCTTTTTACACATCTCCATTCCTTATTCCACTTGGATTTCCTATAGCAAAGAAACCCATTCATGTGTATGGAATCAACTGTTTATAGTCTTTTCACACTGCAGCTTTGGGAAAACTTCATTCCTTGATTTGTGTTTGTCTTGGCCTTCCTGGTGTGCAGTACTGCTGTAGAAAAGTATTAATAGCTTCATTTCATATAAACATAAGTAACTCCCAAACACTTATGTATAGGACTAAAAATGTATCTGGTATTTAAGTAATCTGAACCAGTTCTGCAAGTGACTGTGTTTTGTATTACTGTGAAGATAAGAAAATGTAGTTAATTACAATTTAAACAGTGTTCCACATAACTTCTTAATTTGTACATTCCCTCCCTTACTCTTCAGGGGTTTCCTTTCAGTAAGCAACTTTTCCATGCTCTTAATGTATTCCTTTTTAGTAGGAATCTGGAAGTATTAGATTGAATGGAAAAGCACTTGCCATCTCTGGCTGGGGTCACAAATTGAAATGGCTCCTATATCACATAAGGAGGTCTTGTATATCTGTGGCAACAGGGAGTTTCCTTATTCACTCTTTATTTGCTGCTGTTTAAGTTGCCAACCTCCCTTCCCAATAAAAATTCACTTACACCTCCTGCCTTTGTAGTTCTGGTATTCACTTTACTATGTGATAGAAGTAGCATGTTGCTGCCAGAATACAAGCATTGCTTTTGGCAAATTAAAGCGCATGTCATTTCTTAATACACTAGAAAGGGGAAATAAAGTACACAAGTCCAAGTCTAAACCTTTAGTACTTTTCCATGCAGATTTGTGCACATGTGAGAGGGTGTCCAGTTTGTCTAGTGATTGTTATTTAGAGAGTTGGACCACTATTGTGTGTTGCTAATCATTGACTGTAGTCCCAAAAAAGCCTTGTGAAAATGTTATGCCCTATGTAACAGCAGAGTAACAGAAAATAAAATTACATTTTATAAACCATTTACTATGGCTTTGTAACAATTGCATACCCATATTTTAAGGGACAGGTGAATTTACTACTTTCTAAAGTTTATTGATACTTCCCTTTTATGTAAAATGTAGTAGTGATACCTATATTTCTGCATTGTGCATTGTGACACACTTGTCTAGGGATGCCTGGAAATGTATAAAATTGGACTGCATTTCTTAGAGTGTTTTACTATAGATCAGTCTCATGGGCCATCTCTTCCTCAGATGTAAATGATATCTGGTTAAGTGTTATATGGAATAAAGTGGACATTT + FK3KKKKKKKKHIFJKIKIJJJCJ?JKGJ?FDKKKGKHKJKIHKKKKKKKKKFKJJKJKHJH=KKKIIHEKJKJKKKJKJH@KKKJKKJIKJJKJGHKKJKIHHKKHKKKHJKKJJJKKKKEKKKF1JJKKKKKKIIKJKGKEKKBKKHIKKKKK@KJJKKGAJKJKJKKJ5JKEJJKFKKKIHA>JKKIJHJDKJKK:KI=HKKJKJGJFKFKKK8KGF5KE:KKJJKJKAKKKIKJKKKKFKKKKJKHKKKJGKKFKEJKGGKK6KJKKIJKKJ-JKD=KKIK=KKJKKKFKCJ8KK;KKKFKKKKJKJJKJKFKFH6GDK(GKKKEKKKIK;KKIKKKJKKGKJKKKKIKKIKKJK7KKJJHJKFKIJKKJJ7GF?CEJJ:KJCKK4JJFKFKJKIIIBKKKKKKKKK:KCHH?HGJKKKKKCKKKJJIGKHFEKB7CKIJJBGKKKKKKKJJIIEKKIJJJIKJ>FEKJCFFJKEH>KG=HHHA@EE>HE?JKKCKDBJKJEHKJDI>KKKKAKKKGKJJF-HJHEJ5CE?KH0GJKKDHIHKJ3JKIFECJBKFJKIDHDAJIEGC=JIJKK2KJIGDAGCIDK8KKFJEDI9JHCB@IDBI8HKGEKI>8JKDJI4GJKEJHKICIJ@FEJKKHKFIHHIH4JKJKIKJJIIJGEIIHGJKIIHKKGKIJJ@HHKKKJIIKJAJI@KCDH4KKBIKAK=HGJGIJAJABFAGIDHHIJKJCHKJJICKK @rCer/438/0_1336_CCS TGTTTTTACTGGTGGTTTTGTGGCTGTCATTCTAATGCGTGTGCTTCGGAATGACCTGGCTTCGGTACAACTTAGATGAGGAGACCACCTCTGCAGGTTCTGGTGATGACTTTGACCAAAGGTGACAATGGCTGGAAAATTATCCATACAGATGTCTTCCGCTTCCCCCCATACCGTGGTCTGCTCTGTGTGCTTGGCGTGGCGCCCAGTTCCTGGCCCTTGGCACTGGCATTATTGTCATGGCACTGCTGGGCATGTTCAATGTGACCGTCATGGGGCCATTAACTCGGCAGCCATCTTGTTGTATGCCCTGACCTGCTGCATCTCTGGCTACGTGTCCAGCCACTTCTACCGGCAGATTGGAGGCGAGCGTTGGGTGTGGAACATCATTCTCACCACCAGTCTCTTCTCTGTGCCTTTCTTCCTGACGTGGAGTGTGGTGAACTCAGTGCACTGGGCCAATGGTTCGACACAGGCTCTGCCAGCCACAACCATCCTGCTGCTTCTGACGGTTTGGCTGCTGGTGGGCTTTCCCCTCACTGTCATTGGAGGCATCTTCGGGAAGAACAACGCCAGCCCCTTTGATGCACCCTGTCGCACCAAGAACATCGCCCGGGAGATTCCACCCCAGCCCTGGTACAAGTCTACTGTCATCCACATGACTGTTGGAGGCTTCCTGCCTTTCAGTGCCATCTCTGTAGAGCTGTACTACATCTTTGCCACAGTATGGGGTCGGGAGCAGTACACTTTGTACGGCATCCTCTTCTTTGTCTTCGCCATCCTGCTGAGTGTGGGGGCTTGCATCTCCATTGCACTCACCTACTTCCAGTTGTCTGGGGAGGATTACCGCTGGTGGTGGCGATCTGTGCTGAGTGTTGGCTCCACTGGCCTCTTCATCTTTCTCTACTCAGTTTTCTATTATGCCGGCGCTCCAACATGTCTGGGGCAGTACAGACAGTAGAGTTCTTTGGCTACTCCTACTCACTGGTTATGTCTTCTTCCTCATGCTGGGCACCATCTCCTTTTTTTCTTCCCTAAAGTTCATTCCGGTATATCTATGTTAACCTCAAGATGGACTGAGTTCTGTGTGGCAGAAGTATTGCTGTTCTCTCCCTTTCTTCATGCCTCCTTGAGCTCTCCTACCAGCTTCTCTTCTGATTGACTGAATTTGTGTGATGCATTGTTGCCTTCCCTTTGCCTTTGGGCCTTCCTTCCCAGAGAGGGCCTGGAAATTATAAATCTCTATTACATAAGGAGTATATATTTTGAAATTTTTAAGTTGCCTTTAGTTTTGGTCCTGATTTTTCTTTTTACAATTATCAAAATAAAATTTGTT + S&$,,,+*+((-)$,$),)-/%,)&&150.1+.(/)''()../(35/3655.2,.51560%(*',3.3065)13+0.#'*//..00.53-4145105/61-*2*440'22*552400$,$*,+*,-,52666626*)*1.05/434.1--+0'0223621/*-3/641664-/110.02/,52144,#$/$-)24,3211#1/2.342%1656516464,1120-.2-63-'2%$/0525+-1-03435/+01102.,4)000,+(%.1///.2&34236//422(&+/6044/3005///*..).45,424365611,140522)$/*42./504.1*5440614/,504663600//+5+43.5455126142/265110450,14/'.1,/)/5231-/-((-(53448:22752535-44;::428505855871755497196:668-444:6755100006::8.2898;:583877223754%5+13825748388-6/+6336:*8639324:58563:82*.3'.8657::908928:684/;8.67:96.51,879836;:85744,251.4580/0684567*1041..*-:4/.2/+.,7894974-317558.5,9347762)+()02.754:3357.203.554+7/1558)4347%1%-343.,38*93&26::443/.(452'3626:52./,10,0594:45321-,-2*.3/..32$/+)+'67:7579193+-858;304624748:8;99856934/84205.**2-58235.66586+-+0*61/-,37;7447(%00.01655684815388*4;9;44:2*7'/888-24/08/8:824488837358799:1::;856:35:/955364:5754%76311.4:0.244:67588-7.23&84954+0053:4*465-2-00:5,611014249:::629/21141.7.-5.,%-%%---//,-.).(150+,/+3422-./0+-./16-0%-150112&324420.'4(231/14/0501'-)2,34544-+0414*))0*/40(3/-41102053-1131..2-%5005.3.0456442/040+%.(-3/534,#2*-.)2)+1-62503)2/&*3652.51./554*4,*)+&(+/+-.*)&+**+1*0)&&+.(,*&+##*%*%*'&0-0,+).0&-.+**-)+.-$00/-101-,1,21,0'.0.21--.0-',1(-,.+*1,0&10)+(*+&&($$+-1*)%(%-..+1.&//-1-,/11+222.2.0,11.'0-+-'%%+,-..-2&.)/0),,,0/1-2122,(. @rCer/439/0_440_CCS GATTGACTCCAAGTGTCTGCACTTCACTCCAAGGACTGGAGCAAGAGGGAAGTGGTGACCAGCACTGCCACTGCAGTGCTAAGACAGCAGACTGGGCTGATAGCCCACCCGCCTCACTGCAGCTCCACAAAGCACTCTAAGGAGATGGGCTGAAAAGCTCGAAAAGGAGGGACAGGCCTGGCAGGCCATTGTGCCGGCACAAGGCGAGCTCAGGCTCAGGCTAACTCCAAGGTCAGCTGGCACAGGCCAGGCCTGCTCTGAACAGGATCAGAGGAGCCAGGCAGCTGTGTACAGTGAGATGGGGTGGGGAGCTCTGTACAGAGGCTGGTGGTTGTAAAAATTTCTTTTGTAAAGTAGAAGTTGGGGTGGGGTGGGTGCTGGCTGCAAAAATTCTGGCTTCTCTTATCCCATTGCCACGGCAATAAATTGTTTCTATATGC + SKFKKFKK/KHKKKKGKJK'KKKK/KKDKJKKJ&KKKK?K-KJGKKKJ0KKKKK)KKKKKKHJIKKK7KGKKKJKJ%KHKCKKJKKKKKK/KKK6KKC1KKKKIKKKKK?K:KJJ>KKKKK@KKGHKFK@KKK6KKJKK?KKKKKKKK0KKKBKJ2KKKKI2K*KK)KKK6K5KK>K(KK$K7KKK+BK9KKHKBKKKK0K1KKKKJKKKEK1KKK4KIKK=K1KKCKKKKKGH4K:KKKKKKK'KKJEKK8KKKFKKKKKJKKKFKKKKKH#KKK1,KKKKKKKKKDKKKKKK?KKKDKK'KKKKKAKKKKKKKKAKKKKKKKKKKKKKKKIK7KKKE&KKKE6KKEIKK:KJKKK+KKKKKKKKHKDKKKKKJKKJBKKKKKK2KKK8KKFKKAKKFKGGKJEKDJCHKJJJIJJHKKDKK?KJK@>AII@GF>CKKI?IHIIEHKIDJKKGG/BJGIIKEJKK>E=@FGEIIKGJHF?DEKKH3JIEGKJKIJHJ:DHKIKIJIJKKKJKJKKJEK>IHEJIGIEJDJFEIIKJIJBIKIKKFKFJKJGKKJKIGEHEG@KHFKGKKAIDCE=BIKI7HKKKKIDGDCDJKK4EEJCGJHIK5HKJJGKCKKKJFGDJ@EJD8;<@JIKCJFJKKA0GCHFEHGJKAG>IIJKKJJ;JKJK7JKEKJGFKIBGEIHF?EF6EB3CHGIHJDKKBI=EHG&GB@AFBK=KJGJ;DJDIJBKKJGG@JBKJI>KK@GEGJAA9?JIBGJ@FEKJ=KCJKKH?FEDKJIKKK8JKIGHJKIKKGKIKCADGJJKK9FJ2I8;JFJKKKKKBKKJIKIKHGIK2KKIK7JKCKGIDKKH21;HKKJKHKGCBIAEGKKKFKKGG2>HIKJC1=CJKG>>KK-FKAJKIJJKI@IEKD@KDGIKK6K?KCKKJGIIID.KIKHB=DEKG>C?B7JHH5JKEKKGJJAJKJ>JKJ7HEH:FKK@KJ@EKJKKKKFHK5=KGKJ=KJHKKE@JKKKHIDGIH-I=@:EKK:KKGDKJIJKCJKKKKCJJKKJK;GHJBJAKJIJ:IJIFIJEKCJJADDG.HI;JKI@K>JCK6JI?>:KK@KKKKJJ0JKGIJHIAI8HDGKF@KFBF(IKJ@KKF7BKIHH:DBKKI@FFHK:KGKFIIJH6HAJJKJKK::>JJJKKGKBJKK@GEAGKKK=KKKGKKKHKKKK:IJJGK/JJKKKJCBIKK=FIJIEDHHI/EDEHJK0JKCIFKADAG>KAK9HFHAEJ4H3KJGH.KDKDKBJHAIK?IJGEKEJJ?E7JFGDHHKK=JHBB-EK7EEIDJCHDH5=A@JK>KIFIH6@AH2AKDH:>EBF8B@K6JGHIIIIKJ2@F+CI @rCer/443/2176_57_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCCTAGATGTGATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGTACCATGGACCATGCCAGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCAGAAGTCACACGGCCGGACTCATATGAAAACCCGGTAGTCCACTTCTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGGCCGAAGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCAGGGCACGCTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTAATCCATTTGCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCCACAGTGTGCCCCCAGACGCTCGTGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTGCTGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTCTGTCCTTCTCTCACTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAAGAGTCCAACGTGGGGCATCACAGAGAGCGGGCATGCCCCAGGTCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGAGGAAAAGGAGGCAAATGTGGGCTGGGCAATGGCCTCACACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGCGGCCTCTGGACGTCACTGTTGCCTGCATGTGGCCCAGAGCAGCCTCTACGAACAACCTCGTTTCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCTCCTGAGAAGATAACCGGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGCTGAGCGGATGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCACCTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCACGCTGGCATCACCCTCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCACTCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAACAGCACGTGCTGTGACGATGGCTGAACGGAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTTTAAT + 5650&4467154:55),32-34'5842/57575+35'.2361947352,)5757>8626B?C@8B8:@==B>*:>>300?81G=GJ4BDH=B@IBDF+>B/E6JHDDIH@AFFG7?IJ:CD@AD@F&:$CCCJ3EI5I.CDE%KGG4BCG=DB=:?EDFF7*?GH+J;EHDIG;DGBF:,CF@E7D==3B29?0>>4A=?A,B?@AAB4GBFE?47.CA8@F@JK;H7;;GCE1FI:HH9>FJJG&:EIFJKEKJ1IICFF@IBIDJFGH-DKKE=AE$>GK-@DDFDI'H>C;C?HIHH2D:>CGHI==JKJ1EA=9DIGJFKJJD1:C%DJ+&"%F=K;K>C2IFEDB>F*FDCB9E,FB-<6GI9E2C?JI)K8JKH,HG-?;8F'IKK9JHDA,DKIHKDHH;E3GDHHJJHFHIIG3HAEGG-ED)CFF;GDAJB?DIC@IDGBHKIF;IJGA:FHHHAFEAC?A2=7<@.CG?%G,FH?BJ+HFGBI9HAD>BI8CG:HED=ADE?8=AFHG4G:CBKH0GG=IDDIG4HGGHKJCEJ=IBGJAEEK@E:@D@A=H@HAI2DDED(;FA>:3A:8*C5&>DAD;C7*DF6GF8@DE.F6D.JJHB>=DCB38BEK;JJBGID4H?;BCB8DF;4HK?III4BJIHG=@FKK(E8EF;DGI?IE)?CCEEEGGKBJ&B@GFDG0GFCCFDDBC=JF5FHC6EGEI;?FCB<>C?IFGEEED)FCE<<@?B)H-$=GCGGJEHFFHG0FIFJHFD0D?)@F;IJ7AJAEI/G@HGCIDH8KDJDDAJB>JFI1KKKDC;IIIE@BGCDEBD=BKDI6IDAK2IH=?EEEAKKAIE)@GAG?)CD=EK+8CAJJ>(C5F:>GJFK@DJ2>09JHJH8+/G,KJJIJGGK/BFECG-G@GAE>,I7GK7HHFAD;JFIHBAF5=D?GAJHG>=HA-D5=5@CA<4@B?CCDEDH2JH1EA@EIGF3AEBC?=;AA6G?7D3>ECJDB&%);GIBCE5BA3GG?=G$>@HB:GJIGCBHJ8FGEJBF2AH89BH??.GGEHEG,8G*(/CF3JI;H>EEDCDF8;=4AFHBD=F(FBGFGIEF*'HFDDD'=DG6EHC9@DDA?*CFCE@5;.>=C@<4D-EF?7F7<)HI@HHG+@CC;DF;BCBE?&FIF1@CEICDBG9C<7#EIBE0F:8EE>9(5?4B>G2HCIIF>E?HFDB=C'F?BGIIG>G>JCG.EI5E@6-6=CB8;>CH:F?-=CF1GI?9GFF1?;E35;=;;;@IBDCAGGFIIEBFEE>?BGE@GDFAA;7:9DFCA)?EJJ/H::6;>>961874%8*2.7/'18:764'48870645=38<20?64<1=:571",749=6/3782:1:(162'7);)056886(:.381%/;'8:49>;=9::6054791)3(>398/7'':'<9-31)&.&9<$010,)//;37967:87%6894:6791&/1257<43524422&/$5;82&1(-'70776*<73*40+)131,6,6200356)')7474/,%780'66:104)3(6999+992/%-<=97594$2.))857170;:,>8>5$3/95/0%<<98&6(93568,8855%&39<=.46;-0<;%%07;;*#454*1-088(&66/903*(616+344)32,.(<,4+245'272*"*67*0)6;05<24740'.514210$0848)15':214961*6788;14&*.24%38836*8<<76%5;848:9.2-:7;(<7787&939058320'$&0)=25<91875**(07:99>2=9953*75#+01*323018=.<<7=:;:7*::5/(&5%0884)'7>46*162%(-9)<7:-87<:(702*/'+,.5415-01.2538-7+371,;18?3*6/*+5+$,0699(<6*72:9663442'18.1/'036363/3/1+/*$+670;1080;78'+--62246.177-&445,*4.386,2-/,1,')1/53692+,32(/3-212%5'+507$,3)24,4$343160$2-4-+7-:92576$'043$)8(7+64.2168/6;750+4291&28)*)60)./.-.25*/'%*%.11215.12*50&/./&*.)%%/,%*0*+./)++.&+(''&.*/-.&.,*,+()//(+-&0.- @rCer/446/0_1695_CCS TCTGTCATGCTGGTGTGGTGCGGCGGTGGAGCCTGCGGGCCCGTAGCTGTACTCTGCGAGGTGCAAGAAAGCCTTTGCGGTGAAGGTGTATGAAGGTCATCATGACAAATGTTTTCCAAAAAACTTGTAGAAGGCTGTGAAAAAAACTACTAGGATCACACGTCATGTATTGAGCATATAGGTTGCTGTAGATGAATGTTCTTTGCTGTCATGTTTAAAAATACTTCTGCTTCATTGCCTCAAGTGTGGCATGCAACATTTTTGGAAGGAAAATTGAAGACTTGTTCAAGAAAACACGAACAGAAGCAAATGATGAAAATGAGCATTTTATGTGATGTTGATAACATCACAATAAATTATGGAGAAAAATACATATTTGGCTAACTGTTTTAATTGCTGAACAATAAAGTGTTTTCTTTTAAATCAATTCTAAATAGCTCCATTCTCATAGTCACTAGTCAGACCTGTTTTGAACATATTCGAAAGATTATATAATCTTGTGAATAATTAGATTATTTATGGGTGGTGATTCTCATTGAGGCCAACAGCTGGGAGACATGTACCTCTAGGTTCCCTGTCTGGCTCCCCCTTCAGAGTTTGCTGTTGTACCAGATGGTTGGAATCTTAAAGCTCTTTAATGCCAAATAGCAATCAAAATTCCCCCTTACAGATAAAGGTTTCACCTTTTTTATTCAGTTTGCTTTCATCTTTGTGAACAAAAAAGTCATCCTAATACTAGTACATGTAATAACTAAGCAATATGCTATGTTAAGAGAAATGACTGGGCAGGCCAATCTGTCTAGGACTAAATTGGCAAGAATTCTAAAGCTGAATTTATATCTGGGTGAAGGCTTAGAGCTAAATCTTTTCTCCTGTTGAGTACTAGCTTATAAATTCCTTTCACCAAGGTTATAGTTTTTATATGATAAATGGTATAAAACCTGTATAGCAACATCTTAGTCACTTCCCTCAGTATAGACTTGGGGGGTACAAGTGCAGTTCTGTTGCATAGGTATATGAAGTTAGTTTGGAGTCTGAGCTTTTTGTGCAGCCATTACCTGAATGGTGTACATTTCACCCATTAATTTTTCATCCCGCACCCTACCCCCTTCTAATTCTCCAATGACCTTTAAAATACCATTGGCAATCATATTTAATATTAATGAATTACCTCCCATAATTGTTTCTGAATGTACACTTCTACTCTTTAGGCACTGAAATAAAAGACTAGTAAATGCAGCCTTTGTAATGAGAAACTTAAACATTTAAATTTTTTGTGGTGAAGTAACTATCTTTGAGACAGGTTGGGTTTTTTGAGCTGGAGAGATTAAGGTGGCAGTGAGTTATGACTGCATCAGTACGCTACAGTTTGGGTGACAGCTACATATAAATATGTATATATAAATATAGGTAAGTAAATAAAAGCCATCTTTGTGCATGCATGTGGCTCACTCCTGTAATCCCAACACTTTGGGAAGCTGAGGTACTGAGATGGGAGGATAACTTGAGACCAGCCTGAGAAACATGGCGAAATCCCGTCTCTACAAAAAAACACAAAAGTTAGCCCAGGGTGGTAGCATGTCCCTGTAGTCCCGGCTACTCGGAGGGCTGAGGTGGGAGAATTGCTTGCAAGGTCAAGGCTGCAGGGAGCTGAGATGGCGCCACTGCCTCCAAACTGGGTGAGAGCCCCTGTCT + S,&((%+$*-(%&'*'')%#.&,)'31030,,4/+7564)*63,2641+&5-6441,9736341+3+*369335;;52.67:8525455765(7266:4,579<6)33976$;512<&646:7637+(7/24-247;58%7::988<=;66;7:4766,3989=047303<89.0/16/078+247.9//065;++1'(5-)8600#1-+4/-32/&'+03.57038772-/721253::8;5842209)&/95%),,$,.&$(512.6,6:9976-09+15A;5;:6.1%35776AA6@9=;;>96)4;:3>?@+:>>:;8=<<-5168=849>4-1>:8.9?7214>44*586359??;A>A95B=B:A>A93A>@1?9@8:9=9?<8316>A@2??>16=EAF?1DCB@=5EC@=AFF=84@@-?;?=8>36/;99;3;<>=4&@B<3<1=1==>4:?BAA>C;A=@;=?CCDC@E-CGFCEEB:=A9>49<=@A9?B;:A@/2*,547A<:9<==><5A@B4>=4AC3A@?8@597=<5>;@>=%3189E4C<>C>9;;>:@AB><@@;E,=C:;9;::798<87A?:B:EC2@-;>-53195?='75970?C6+47/-81?99=;/=:89@>@6=2???F:C38A>=<::<958?A=@=73BA92;=>>=;+3,*.)-A:@=?CA>@=D<;BC>C*<=?@?A/A>@8@?:<%67-38>;<46@?=A977?A=?;A:+9:86;/.*/1:**4%0-.-36;?;<=:3>;9:*8:<<88-5:5-465628/;>9=865>7;:?A;7::;>?>11893+8==;954:-492.%202.-7>@96>9?,37<4><;11:0<5.9;:;<695.>3=:%&<@95A7;?8=:8?A4>>?884:<;@9,=9791,.3<6=B9>7><23.8@?>7;=9<;A@9??B?C?;+@7>?8;:8754==/=78<=960222=4816+4=7@?>-;@>?7<=;=A??4C?,2><;7>;@1/'6,6):>2=5?39;;>70068<8.5487;.<@;@>59?/=<9=$36.+4<;;=84<43723407<@>A=997:=;41/5719641:>3@?:7?8;;4;??6=3AB3>=<=?-;B<>9@?>2@:;A>=:;?A?72<5%6=5:=;>5A71<92<8;;@948<6AB<.1A22?88@?151<55::==9?7;9:>?5;>=@;%5531?9=;?=:6>9;.6732;=:3:5/32%@=8>65>=*?:;AB@??8?>A=+6AAA?*3695;:=A3>5<@B:C?<1<8>>@??8<=7>:;4>>;?B>?9B;<8;?:6>A)@?==7A?CBA85? @rCer/449/1957_56_CCS ATGGGGTTTCAGGTGTAGAGAGGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCCCCTGGACTGAAGAGAGGGAGAATAGAAGCCAAGACTAAGATTCTCAAAATGGTTTATTACCCAGAACGCTTGTCTGGGTCAGTCAAGAACCATTTCCAAACAAGAACATGGAGGGAAGGCTTCCTAAGGGAAGACTTCCTGTCCAAAGGAAGTGAACCGCAAGAAGAACGATGAGACAAACGCTGCCTCCTGACTCCACTGGGCAGCAGTGAACTCCGCTCCCCAAGAATCAGTTACCTCCACTTTTTTTAATCGTAACACCTCATTTGTATTACATATGGTGTATGGGTATTGATGAGGTCATGGTATCATATATGGATTTTTTCTGTGTAAATCATCAGTATAAGAAGAAACTATGGGACTCTGAGCCTTGCTTAGAGAATTTACAGTGGACAAATAGGTATCATCAAACCAGTTTTTAATCATTCTGACTCAAGTGAAAACGCTCAGAATTTCACACTGTGAATCCACGTTTACAACCCTTACAGGTGGGCCTTCAGGCCTGGTTCGCTACAACATGTCTTCCACAACTCAAACTCCCACCGCGCTCACACAACCGGTCCACTCCTGCCTTTTCACTCACACAGCTCCCGACTGCTTCTTGCAGAGGCTGAGAGTCCCCCTTTTTTTTTTCATTTAGATGTAACAAACCTAGTAGTTTATGTTCATCAATTGTCTGTATATCTCTATATTTTATCCATGTACTCTTTTGATGTATAGAAGTAGTTTGAACTCATTGGTTCCTTGTGGTAAGTGACCGAGATGCTGCCACAGGACCTGAGACACTGATGAATGGTGCTATTTTGGACTTTCAACATGCTCCTTGGCGAGGTAGCTCTGATGGAGTTATTTTTTATTTCCATGTTCTAAGAAGGTGTTGGTACTCTGTTTCCCTGAATGTTGTTCTCTAGACTGGATTGACTTGTATTCCTTGTGTCTTCAGTGTGGCTTTCTTCCTCAGTGTTGTAGGTTGAGCGAATGCTACCAGAGTGTGAGAGACAACTGTCTCGTTGACTGGCACTCACGGACATGCAGTCACGGTAGCGGAGCAATCACAAAACTGTAATTTACTTACCAATCTCTTCCTTTCCGTAGCCTCGCCTGCCTGACTTAGAGAAAGAAAAGCAATAATTTACAGGCATTTTGAGGTGTCTCTTTGGGTTCTTTCTGTTTGAAAGGATACTTGTGGAAAAAAAGAGCAAACCTTTTTAAATAAATTCCCCTGAAAAAAAACCCCAAACACTGGCATCTGAGTAGGAATATGAAAATGACACCTTTCCAAATATTAAATTGGAAAGCAATGTCTTTACAAATCATAATGCTTTTTAAAAGGCAGAGCACTCTTTTTTTGGCAATTTTGATAAGCAAGGTGTAGATTTACATTTTTGTCCTTGCTCCCAACGAAATGGATAAACAAAATAAAATACCATCTACTCATGGAATGTTGTTGTGTTAGCCAGTCTGAAAGCCCACCTTAATTTTTATATAACTGTCTTTTAGCTCTTCTTTTGACAGGGCAGGCCTTGTTCTGAACTGTTTCGCTTCTGACTGTTAAACACCGATGACGCATGCACTGCACTTCTTCGTTTCTTCTTGCTCCCCCATTGGCCTGAGTTTCTTGTGCATTCCTCCTCTCCTCCTTCGTTAGAATAGGTATATCAGCTGTGTAATAGAGCAAGAAAACAGTATTCTGCATCTGTGGCATTTATGTAGAGTTGCAGTTGTGTACTGCTGAAAATGCAGGCTTTGTAACAATGTGATCTTTACTGATGCACTCATGACAAGTACCAATGTATTTTAGCTATTTTAGTAGTATTTGTTCAATAAATATGCAAGCTG + IEI-$%#,)GJKC=GC53C=BI.D9C/A77IK?DIKK>E?JKKK'HKKK+JF68EK9KG5&1H$?K09E2KKI>BJGJH%CHKFFJHJ%DJ$)*;IIHK>BFK0K6JKKK-KKKKKE4KFDKK@HKK=KKHK%IKCEKKGJKKKKKK7KKAKJCKK2K>KI3KK/FKIKDJKJKKKFKCK@DK0JAJJDKK)K;@J0K*KCFHHJ*BJCK8G;GJJK3K6KGJ;FC5KK3KKKKG@JDKK9JKK@IKIKJK'KK@KI:IK*HKEK?K<;EKI&KKKJKIFHJJKKK1K8GKKKKJ;KBJGCK,GGKFKKKK=IJKKKK.KHCEKKKK-KK06HE9HKKKKKF3K4JKKKK,GEK:KKDK9I8JK7KKK=K?K=KHK7K3JKCKIIJJKJKKHK)KKIKKIK@HGK>KKKKK22=KK9FKKKKKJKG<1BGKAKAK@FKEK;9K-KKK2KKK6KKKK7KFJKIKKIIK2KKKJKKGKKKKKGKJKKKKKKKKK1K;KKKJKIKKBGKKKJ?IIIKK+CKK>GKBJKJKKKKK7KKKKKJK?JKFJK=HKK3GJ'*JKKKHK*KGF&KDKKKCKKKIKKKKJKKHHHKJCKK0JJ2K@JKAKKKKJKJCHKKKKK>;KKKKKKKKKK7K>KJKK8KK=KJEDJKK3IK*KKKCKHK?JK*BEKKJKKKJKCKK;KKJKIKJKK6K1K0H<4HK6FKKKKJHKKKKIK*@CBJKJK'CJE?GKEIK&41KF)?IK2KK/KGKJKK4HIKJKKKKKK=KJJK5KJKJKFKKKKKKI8HKK6K=KIJDJKJJIGKKKKKK.KAKK0KKK;J@JKFKKKBKGC;@KIKKK>K@JKKKK2KKKHKKKK@EK.KEKKKK2JKHHFKHIJKKK/HEKK>KKK;IKIKKDIHKKK@KIJJK=KFBKKIKCKKKGFKHKIKKKCKKK,KKKKKJFKKKK9K;KKKJKIKKKKKK+IKKKKK>EKKK;KKIKKKCIKKCK7K@KKHKKJK=KKKKK:KKHKEKJKKKJHK@KK;JJKIJKKKKJHKKJKKKIFHJH8K:KKJKKKK#EKEJK3KJAKKKK(KKKKGKJKKKIKKCKKIKJDJIKAKIH):>KGKKGKIKGKKKKDKGK&HFEEKKJIHKKK8K@H;8D*HHDJGHFIGEK:IDED;KKKJKJEJKIKKE>HJKGGHFKCBEHK&AAGHKKKKK1JKKKDKKK7EKIDJ@KKJ'GK5GD>9:813<9;.76,74;65839<9545$8==1*87;:1/?9221>5>==56?7:9<<)8:3501<968*=6=;>187;>8:913/25:88?=7398=7?5<:;9<6/-$:8(;<;;60<87=5/5::=>>98:77:5778.,)4;907..++*99;=6=97=4+,87<88>>7=48$0;';>417:7=::<=527==16794#3:?>:=99;2:<2<2:882/<8<:774<;9'986:67>91;.;5>17859>98<8:86.008<86;4:<9:><91+/5;<=):>56957%7:19>9+35;;::=9<>?=4:=:;=0767<%279=>;=<>+?:6=7<>7912;<.;87>2166+909057<25=2:<:86467;783=4+67>2:>:608=9/;7;?97<7=;2??79::5<0349%84:*>>?=7<8/?<;>;9<:83+?:>>8:&;=875:>697:26;:;=*#5)$)968<2<;?3834$4>;:7<645&48*8:7%$*4195999.887:>::307=::>0;:.4.;;36,959<:?5889/:64%>077=3>;=;><9:;'6=.3;33/::28:7=>=8*9=961431=9;45>6:394<;9=9<:>5=:>;<=8::6378:0757><98=<:;78,.)+46;;?8997?<369?8>1<1>;<=29:06794,9;$48>?:<;;2;?:;9348-:==36=:4<;8<=58976;7682=4<>850=1>89/799;9;78<38*298<==;71/<8(3991.6<:97**39=<:87194:+<;;??89=79:42.10&7708;8427.:44%,8840,268-7890633'$'/&/775578.898:8536947,852(41-4549767698457770*317:559:888::78,345737+677595914:,48:9;7985:09-0)895'91,2/344+-003.51&/.7:;97375:744:6.:36952/26*5867678999/539;::9:0,95:5,+3742.549.73+5+86'20455659769-512466'73746551106:8:;934332'2775554.51'3365897/0/4.6.5/)5003751027:;;4-9567574-5445:76903595-10011-/14'9.403844'125/8966.7::8.047:70571538(9544738628:875+2043)4.004095:97:7:08&08/:::726776744/&2029939267-36+'8:57:75.58625552828555432435688:7077613564.45+-&39:*4286:3.:543127-8466277+3973%:179+7688719:-68245*6343108:07616*-017+4:7.441344141.03276*135/12440/687478)784381795:3::55.6:6:87:42-965353+:82/1667:85945+3::69874/7:3:8897::53996/:244--6476;;38861792-1+3:948;7;984795948958679;959364-4.31*6:6842:949837310158---%2%7376746037.8359(56::6738:6786/3886,-.:8:995:::4956.832*5.8:::9*0,.17:366*98:9;4148/404/4255.6:9:7:819698:547-9881.-0..444+/34.21+9471787645+3613681649;92353:::9;6:5873976;61(:352&20779:.8972.9/96833:956:9:/7:743667014460:254651-735/-%230241796+39344860/5)7+48;577-57:2;::47:65887.9::879918:.7258:68695982536%,-47863$244,)0(,564-6--947:;;:85.--66(2-:.28654965,7776'42,6878+9:7,:69.091::464::8:4$0299959942196'4690::6933//17:623)9678778/::5:986:6757.294438539;65955189.7628::13:::894,&94::55,.25.25990683787)7:66/;6:: @rCer/451/25_2106_CCS ATGGGACTTCGCCCAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCCAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGCGCCATCGGCAACATAGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGGACAAAAGATCCTTCATCACCGAAGTGACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAAGCAGTCAGCACTGAGGTGCGTTTAATGATCACTGATGCTGCCGACACAAACTGCTCGTGCTGACTGGGCAGTGCTTTGAAAACACCGGAGAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGATTTTCACCGACCAAGAGATCGGGGAGTTACTAAGCACCACCCATCCTGCTAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGGACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGATTTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAGGACTTTCTGAGTTTACTGAGTATCTCTCAGAATCAGTTGAAGTCCCATCTCCCTTTGACATCCTGGAACCTCCACATCGGGTGGATTTCTGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGGAGGGGAGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCAATGGCGGATCGGAGAGAAAATCCTGCTTCTGGAAGCTCATCCGACACTTAGACCGAGTGGACTCCATCCTACTTACCCACATTGGGGATGACAATTTGCCTGGAATAAACAGCATGCTACAGCGGAAAATTGCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACTGGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTTCTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGAAGAGAAGCATAGAAGAAGCATGCTTCACTCTCCAGTACCTAAACAAATTGTCCATGAGACCAGAACCTCTGTTTAGAAGTGTAGGCAATACTATTGATCCTGTCATTCTCTTCCAAAAAATGGGAGTGGGTAAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGCAGTATTTTATGCAGCAGTGGACTGGCACCAACAAAGACAAGGCTGAACTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAAAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAATACAACATCCTGGAAGGGTTGGAAAAACTCAAACATCTAGACTTTCTGAAGCAGCCGCTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCACAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCGCAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAACAGTGAAAAAAGACAAGCCAGTAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAGGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCCGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGCAAAGCCTGAAGACAAGAAAGAGGAGAAGGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAAGAAG + KJBKKGIFFJJ6KKGBKJJJKKKKFIK4KGJJKFBJKKKGJKJJFKI?KICK?@JKHKK6KJK7KKKKIKJKKIKKKKJFDJHFKHKKKGGKKIJ7KKJFKKI7KKKKKIJCKKKFJDJKGKKKKJKIKJJKHFKGFK=KKKIKIKKKKKBHKKJKJKKKKHI1CKFKKGKJIKFKJKKKKKKKJKKJCKJKHIKKFKKKKHKKJKKE@IKKKFKK#HJJKJJDHKGKKJFKKKJKHEKJKKKKKFJIKJ9JJC3HFHHHFKIKKKKJKKFKKKKCKGKJJKKKKJH?GG;DGIBIKKKKKKKK>KKKHKIIKCKKKHKKJKKKKKKKKKKKJKK?KGKKKFKIJKHKKJKJDGKKKKEFKKJKKJHGKKIFEKKIJBJJKKKGJKKJKHK>K7KJKKKK2KKJIJFKKFJKKIAKKFKIIIJGIKKHKHDJKKFKKJJKKKKKJKKKKCKIJDKKHKKEKJKIKKKKKGKKIKKKKKKKKJJKKJKK&KKFKKKKKGK@KKKK7KKKKJKKKKKCKKCKKIKKKAKK5KKKKKKBKJD@KK<>KKKKKKKKKHKKKKKKKKKKKKJKKKKKKKKKKKKHKDHGIKKKKKKKAKKJKKKKKKKKKKKKKK?KKKKIJKKK?KKKKKJKKKKKKKKKFKKKKGKKGHKKKKKKJKKKKKKJK:KIKKKKKKKIKKJKKKKKKKKKKKKKKJKKKKKHKKKK?KHKKFKKJKKKKKKKKKKKKKJKJKKKKKK3KKKIKKKKKKHKAJJKKKIKKK=KKKKKK>8E@>JADIGAKFJAFDJIJK?IJIJEBCAFIJ.JJIIJ7HCFHHBEJKJCEIJ=HKJGE.3A;;62=KDE>K>KGEECGDEBDD8A?@=HDH;HGJEGJIFGJ@DBH?FFEIG>HHD4?>G>G9EE4<@5JBBH4=HKD30FIHH6KJEHDHHDFGII?E<=D8.BCEGDGEC@GDEGCFEFE*C@>9ADH8B>4=5HJCGIJCHJHJKBII7GJFBEGHHJFECC@7K=CBE@A@FKCIH4@K@IG==6E>EHIAJDFHK=A@CIBC=>8CGEEGFBFIDEJ5KD=EGBDDA>HGC.HEH;@;GB=D?@H>GFD=CDGF@HIJK9:FCBJKEIHGDFA?DIF9FKCHEJDG>AHIG@H?KGJBJKFKFB5(HGA@D.=IJ@CCF=A>=?EHIF>;BC?A2KHJGEHCKIGGGG;JGBJ4FAJBGHAGHDB=JIFJEIJEHJHGEJIEEE?HGBAHJGH=HHGE@BAGDID;CIGBIEG3HEKHIKHCIEH=GCGBFCEDHCAGEHJCF>7;9HJACJFAEJEFHHG?CHBFB8:%D:HBH?8AA/FHKGAJ4BE<7IIGJJGHE8FCCBAHCD<>@JK>HDDGC?CBIICC@EGGIFIHKEIGGC@HDIAIDKIIHDKK;@AHKJFCFEGGIHGJB5??FC@7JFCBGC;E;GHCIG9IBHBI2=CBB0GHF2BFJ@JHC@;E:IGIF>HBGGCIFJB>KGHHF8G@@<@KFGIF:IFFG>(D?GJICFDHJ$:>BDAEECBIJDIHHF?EI?CDGAGGEBGGGB<:?CFBBEBH??@CF8HJEEK@B;FDG?IDDHIK5GK?HHFIGFCACHFHCID@JGAB>GCF(G=IDE9DFG7FG8>CKJ>6EFHJ=:B@EDAHAIKDIHEH:HDDCBJK=JHD@FBFG>EGDE.C@6A>E=JG;D4G3E@@FGE@JKHHEH@DFHDF/AJEEHKDKBFEJJG?HH<=D=FHF@BJH>@IFH@A9BD3>IIIJ=F8GEGB2A@FC@=9=4D;BD?HJJIFADA,BEG?=BF?@:FEGGB?6FA?@@B54=GEGJD;GEI?F>A0?EC>H@CF3G?IIEJAAG>7:CC=>6<>AD.?=>8?>B?;88&9A8GB?.7B=@C::>FA8=B*C@H>C=B:<<@CE*;>:JEDA?6<@=EBB@A5>B@=->?G=>*>EA>GFHC86>B?8CGB9AGC7B?@=DH8JDEGDJEE;AHG3<31CBEBF>CC1GJAE:G@CA>G<>EBF1CB7BE@;078A@>@A>3=@>>=>B?*9=DCD1A78?>$6+9=3=88?A75D><42DBAEA>8=C@6?=@?(;8;<::-=4=@:?.3>?B@>B=B:=AA? @rCer/456/0_1764_CCS GGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACCGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTAGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTGCATGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAGAGACAGGGTGCTATTGTGGCTGTGACTGGTGATGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTTTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCCTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGTACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGAGGCTGATCAGCATGGCCTATGGGCAGATTGGTATGATCCAGGCCCTGGGCGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCACTTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTAGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATTTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCCCTTCTCATCTTCGTATATGATGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTAGAGAAGGAAACCTACTACTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGTCACCCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCGAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTATAATG + %*(077?><4/0<1=>38398?76;0&:9<>8%/106.-&555589*789$63AAA=7):=54@A=A592/)3698%64=;37<:><98:?A?@7B7C@59<=>;?@5B@86B0A=8:9807:0;=8?97@>A7><;6@7@3A=?.71<@495B08;A<3:19299>3;A>>;=?5?;5<<64A331=7@?AA?5C=;9AB>?=<>3ABAC?=A6><=?7?:.5<<@?;;;?B3><8:5<:A>6<<3?;<@AACAB0::BA:8;287A>;4>:6.=>6@3=><9=A;A;9@?=@9B78.;:<9=;406<<;B;:<68=A=9==C4>??<794><@:>4><=;*;968<8;B?:0;9:5=?3;679:/3?2/5ACA>>3=::;;67>=56=0325>?9:;A1B;@B3???::A(;:;855;412?)0-88=8=?@>*()<>;6?/7>??<490*0?>+5=7?;?9@<.:7.=<<>@:<./B1&0554:@=?6;(;4&<@?=<023;0;=6@=C7@<=8228;>@=1?<9=378=%5:297+47;2?95?785;<*9<:&9-=9<7@=7@608=2>=9=<>8=',6@C>?;4/4>>>9>1<=;8-3;<4:B=:-(6?=1,=A?B@B@2;:5?:51-30<:72A>?8=<+?:>9=@A:48A7@===>?;<=;?6:???A=-:>?/6864?:7?<9?.A?;9<<;@7>>873<;77>=+;>;@A<>38?A@1:5264>=5.719@?>@76B==?:B8>4?7787;:@=3?2A=893;?=:2>>4?B88;94?>3=9:B:>7?93;<2@A>>;3:@:+5<:.8:48:5=<<=<==8879A>=?396:8BB<<2877>%668?@?7A;4=98<==>BB?014%8863)/%(88<67=;:;8986;?@;777>9?CB95<9:6;<;B=9=>:A<;:?B?=B>8<>@4;8'9=CB;;=<.@;86>?579?4:>69098A:A@A&>8&'4:+783;=-?898;4>=;;<(?>:=19??5@?@;>?=@CCAA0>8979>ACCAC?A@AC?>>8AA9A7A9/:<:9=7=>?=?CA;=?1B@BA:A9=>@*:>AA=8AC:A/1:@0=@8;<';:495:8A4;8:?C;@>+;=;:??BBAA@>CA;8<==33;6>3>=4/89.:9:9:.9A=6A;<;/@@@44:::@8:?>@<1?9=5?:=>6<><=>2?7<85+73:+A>23564146*3+1+488>??>>97>==AA@9B1;:61?<;@>AABB<;3>C<;<=B9@)5>,<:31+AA@@79B=99BA)=>=79:@8A2;6=<8?>>@68:@=8A=7=;:67<79?39<<9'::867:0==29>7?7;/:B?7;23&47,-??>:;0<:8+88:7:-<<,@:90879>:;>6@9?2=-AABA>AC2:9===@>=<>B=>A7;5CA:?B>9A;0;@><<:*8.9>>-@?AA=B29:=9=:>.<9BA;=6??89;35 @rCer/459/1634_56_CCS ATGGGGTAGAGCTGGAAGATGGCGGCGTCCGTGGTCTGCCGGGCTGCTACCTCCGGGGCACAAGTGCTATTGCGCGCCCGCCGCTCGCCGACCCTGCTGCGGACGCCAGCCTTGCGGAGTACGGCAACCTTCGCTCAGGCGCTCCAGTTCGTGCCGGAGACGCAGGTTAGCCTGCTGGACAACGGCCTGCGTGTGGCCTCCGAGCAGTCCTCTCAGCCCACTTGCACGGTGGGAGTGTGGATTGATGTTGGCAGCCGTTTTGAGACTGAGAAGAACAATGGGGCAGGCTACTTTTTGGAGCATCTGGCTTTCAAGGGAACAAAGAATCGGCCTGGCAGTGCCCTGGAGAAGGAGGTGGAGAGCATGGGGGCCCATCTTAATGCCTACAGCACCCGGGAACACACAGCTTACTACATCAAGGCGCTGTCCAAGGATCTGCCAAAAGTTGTGGAGCTCTTGGGTGACATTGTGCAGAACTGTAGTCTGGAAGACTCACAGATCGAGAAGGAACGTGATGTGATCCTGCGGGAGATGCAGGAGAATGACGCATCTATGCGAGACGTGGTCTTTGACTACCTGCATGCCACAGCATTCCAGGGCACACCTCTAGCCCAGGCTGTGGAGGGGCCCAGTGAGAATGTCAGGAAGCTGTCTCGTGCAGACTTGACCGAGTACTTCAGCACTCATTACAAGGCCCCTCGAATGGTGCTGGCAGCAGCTGGAGGAGTGGAGCACCAGCAACTGTTAGACCTTGCCCAGAAGCACCTTGGTGACATCCCTTGGACATACGCAGAGGACACTGTGCCTGCTCTTACTCCGTGCCGCTTCACTGGCAGTGAGATCCGCCACCGTGACGATGCTCTACCTTTTGCTCATGTGGCCATTGCAGTAGAGGGTCCTGGCTGGGCCAGCCCGGACAATGTGGCCTTGCAAGTGGCCAATGCCATCATCGGCCACTATGATTGCACTTACGGTGGTGGCGTGCACCTGTCCAGCCCACTGGCTTCAGGTGCCGTGGCCAACAAGCTATGCCAGAGTTTCCAGACCTTCAGCATCTGCTATGCAGACACGGGTTTGCTGGGTGCACACTTTGTCTGTGACCGAATGAAAATCGATGACATGATGTTCGTCCTGCAAGGGCAGTGGATGCGCCTGTGTACCAGTGCCACGGAGAGTGAGGTGGCCCGGGGCAAAAACATCCTCAGAAATGCCCTGGTATCTCATCTAGATGGCACTACTCCTGTGTGTGAGGACATTGGTCGCAGCCTCCTGACCTATGGCCGCCGCATCCCCCTGGCTGAATGGGAAAGCCGGATTGCGGAGGTGGATGCCAGTGTGGTGCGTGAGATCTGCTCCAAGTACATCTATGACCAGTGCCCAGCGGTGGCTGGATATGGCCCCATTGAGCAGCTCCCAGACTACAACCGGATCCGTAGCGGCATGTTCTGGCTGCGCTTCTAGGCGGGAAGCCTGTGTAAACAAGAGAGCTGGGCTGGGGCTCGTGGTCCCCCCACCACAAACACAGCACTCCGGCTCCTCTAACCTGTGCCGCAGGTGACCACCAATAAAATCTTCTGC + HDIII=;FJEIIKKIGIJGCKHHIADCDIC>FI?ADC$DHHHK;KEFFDCJDFJGGFKIIDJDHDJFFIKBKKIHIIJKJKJHKBJCBKEJBJFHFDGF@HDHJIGH7JKGHGFIEF7FHJ@IKKKJKHIJ@JIKKKCGCIJIIB=GHI?J=IEJJJADH;CH=JKCFKJHBDFIIAHKCFKKK,JFBGJJJGDH6J>=KAFHJDEBICKIJFFAHAFDHJD5KCHD-CDFJK?DCJ:CGDIGE@?BD?FJ?BF;GF>8EF@CFA;6GEID?A9<8E@76.767B8D>CGDG@)CEAB6===C@C@:=7;98DEE@?IE40G@>AD1GCBFIFI8KDBEJ=FED9J?H@<9CJI;DGDD@C@F7@EG>BDCGCGHEAF?B949G=GHGDB:5CBG@EBACBHCCCB@D74C=I;GEHJJIHI;KGIDDIHJFHKGGFCJ?CIJJKJHEBAJBC??D4:D@JAC6FJEG=K=HHF/CDEHFGGGGHGGBGKCFFAIA?BH3HJK-GHCHF@EKK=KEFH@IABGIHIGJGA@KIIIHICHJ.J4@IIJCD8EGKICJFKBH<;74=KFHFKAKJI@JKIGE;KFGEHBJFIKIHFFGJBHHEJJ;HCKFHIIIH>FJJJJJHCGFGDDC=HK8EIBKDFE4HJKHFJIFG=J?GBHCIIGIH=;HI1,85@ED8FJG0FBFFE?ICAD@DEGF7EF?FBBGH@>8?@>;)1=,6CDGGGF@A@H=ACGDIF>@D.>A@5F@IDBC3EH>GE?HIIHHGHHEGEAEEGA:??D?JIIBFGHCH@BAFEF0?F?95?<4?ID:HG.@E?FFCIGIFE>@7CEB>CIIIDAB=D7B>@CHICAFFCFEAD@FFBB=ICG=39ACDE@=?:@?5.8A5=@=D8?E:ECH?BBA;C>;B>74DAC<?=;9:=>=;<1)?==;;9531.6@3BFCEFFBBBEFBE?C4E<>?3;AA;A>BE:ADB=@=D::C7=DA?:?BGDBD=GGF9;43B=;CC??(A=:E@FD1<=CACEED?A:EA>FHC=C6JD=D?EHBH;F1<=E;C4BF @rCer/462/2863_59_CCS ATGGGGGACCAATGATGACCACTGGTGGCGTATGAGTTATGCACATGAATACCATGTTTCTAGAACTCTGAGGTCCACACAAATGGGATCTAGTCCATTCATCCTTTGTGAAGGGATCCAATGACAGGTATCAGGATATGCAAGGATCTTTTTCGGATTTTTGTGTTAGTATTTAAAAAATACTATTTAAAAGAATCAAGGCAGGATAAATAAATGAACGTATAAACGAATAGAAATGAAGAGAGTGAAGCGTTGTTTATTGCTAAATATGTATAAAGAAAATGGACTATTGGTGTAAGTTAGAATGGATAATATATGGATGGAATTTATTATGTCTTGGACTAAAGATGACATCAACTGTGATGAATAATAGTTATTACTCTCAGTCAGTTACACTTTGAAGTTCATTTTATTGAGAGAAAATAAGCAATATTTCTATAAATTATTATTATTATTATTTATTACTTTGAGACAGAGTTTGGCTCTTGTCACCCAGGTTGGTCTGCAGTGGCACAATTTTGGCTCGCTGCACCTCAGCCTGCTAGGTTCAAGTGATTCCCCTGTCTCAGATTCCAGGTAGCTGGGATTACAGGCGCCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGATCTTGAGCTCCTGACCTCAGATGATCACCCACCTCAGCCTCCCAGAGTGCTGGGATTATAGGCGTGAGCCACTGTGCCTGGCCCATAAATTTTTAAAAACCAAAAAGATAGCACAAACGAATAGTGGAATATATCAGTCAGTGGAGAGAAATTCTCAATCTTTTATCATCTTCTGCTTTGTATGAAGATGGATCAGAATGAATGCATCAAGTGGGCTTAAGCATTCTGCTTGATGGAAGCTGTATTGTGTTGTGTTTGAAAGAAACTAACAGAAAAAAATACTCGAAATGTGTGATTACTGAAATGACTGACTGAAGGTGAAAGCAAGGATCAGTGGAGAGAAAGTCCCAGATGTCTGTTCTCCTTCTTCGTTTTAAAATCATCTGTTCTGTCCTGTATTTCTCACACTGGACCATCTGAGCTGATTTAAGAATTCTTCCATGGTTATGACTGTATGATTGAATCTCTATAAGAGCTTGGAGACCAATAGTGATAATCTCGAGGTGATTTATGCATTCTTCCGTGGCCACCAGCCTTATGGTTGCATCTCTGTGTTAGAGCTTAGAGATCAATAATGGATGCAGCAAGCTGTTTCAACCATTCTGTTGGGATCAAGATTGTTGTGTTGCCTCTGTGTTTGGAAAGAGACAAGAATGAACACGCTCAGGTGATTTAAGCACTCTTCCATGGCTACGAGCTCTGTGGTTGCCTCTGTATATTAAGAGCACAGAGATTAAACTGACTTGAGAATTCCTCCTTGGTCACAAGCTTTTTGGTTGCATGTCTGCATTAGGAGCCTAGAGAACAATAATGAGTGCGCTTGAGCCGATTGAAACATTCCTCCTTGCATCTTTGTTCTATGATTGCATCTATTTGTTAGTAGCACAGAGACCAATAATGGACATCGTTGTTCTGTCTTGAGATCCTCTAGGGTCACATGCTCTGTTTGCACCGTGCTTGGAAGGAACCTGCAGACCAATAATAGATGGCCTGTGCCGACGGAAGGATTCTCCCTGGTGACGTGGTGTGTCTGCTCTTGATTGGGAGCAGGCAGACCAATAATGATGCACTTGTTATGATTTGAGAATTCCTCCATGGTCATGTGCTCTGTTTTTATCATGGTTGGAGCCTACAGACCAATGCCATGTGCTCTACTTGCACCGTTTTTGGGATGGAGCTGGAGACTAGAGTGAACAACTTGTGCTATGTTAAGGATTCCTCCATGATCACGTGCCCTGTTTGTACACCATGCTTGGGAAGATACATGCAGACCAATAATGGACATACTTGTGAAGATTTAAGATGCCTCCAAGGTCACGTGCTCTGTTTGCACCATGCTTAGGAAGGAGCATACAGACCAATAATGGATGAATTGTGCACCTTGAAAAGTTCTTCCCTGACCACTTGAGGCACTTGCATCACGGTTAGGCTCAGGCAGACTAATAATGGACGTACTTATTCTGATTTGAGGACTTCTTCATGGGCACGTGTTCTATTTGCACCATGCTTAGGAAGGAGCATGTGTACCAATAATGGAAGCACAGAAGCTGGTTTTCACTGGTTAAGAGCTATCTCTGTGCTAGAAGCTGGACACCAATTTGAGACGGGTTTTCACCATGTTGGCCAGGCTGGCCTCGAACTCCTGACCTTGTGACCTGCCACCTCGGCCTCCCAATGTGTTGGGACTACAGGCGTGAGACATCATGCCCGGCCTATTCACTCTATTCTTCAGAGAAGATGAAAGTCCATTTTTTTCCCAAAGTATCCAAAAGTACAGTTGAGCTATGTAACAAGTAGAAACATAGAAGATTGTATGGAAACCAGAGTGCATCTACATGTACAGTAACTAATCTTAAAATTATTTGCATGATCGTCATCGTGTGATTAAAATGACCATGGGAAAGAAGAAAAGGATAAAAATGCAACTTTCTTGATTTAAAAAATGTAACTGGTGGGTGTGGTGCTGTGGGCATGTAGTTGCAGCTGCTTGGAGGTTGGCTGGGTGATCACTTGACATGGGGAATTTGAAGCTGTAGTGTGCCGTGCTTGTGCCTGTGAGTAGCCATTGCACTGCAGCCTGGGCAGCATGGCGAGACCCAGTTCTAAAATAAATAAATAAATAATAAATAAATGAATACT 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5-3259*8:/:558514:;:7(973..*2=<=5/35;/93,6:8<68?;88<,=3/:9%==;2984:<=:34,7;5&8;99=+=>>.8>>::<>?9;=8)67<2::1<;9:2>?4;8;0<*9%:3;:37<9200+3:;99*63=:===;:75%58*68:;3+/287+:8-4-/*15-/2%6514-98%-98+14674824*5971358:/9662.396666.35536::154702&847-424767994378;+52:-:;652896(10:70%,*5%0/,1%.527096;3;67568-8748875.:39882924059655934&79+*:56740.;6;65/';728-33-(4673690413458;933'982:4.7146.7955389'7;*995%6;/7:7:756+244%96'673//73/'88/850#',//*975762%82292151.2--3(0-+#1/$2353+4,3+6-43344'1&23)55597864'8:491;87:8768:66'376,$278%:5(5680226.5$17/25.5:3+06-;87742444:1445,54/,674346*-,35324-.766)36.4647*4/53(59.8:-8396534',32&887,*7229987+442526875630&89)*'1%-9:934)61.62109569:/7513687::76(98.-3(-1+&/05/6917:2366857'99:.876/16+9;9515:586762-5'99495894.5069/6522-4085&,-74(400220$+06490-.67'7(('7856532/)&,.13&+9853.530,0)67,4/278820)8630.0'+)/9..'2381+&'%&14'345;9871448/:25/7:3317;508;;89;7;67::851/3/;9926721&/-326890%025032157)&$2'4//)7283.57999588+56759889-81982:640-99:98096)-8632295,111136%289(;3678525/-959479(5,'5&368917-1591097&;5598:6983,675%54:9.89;498631.083485(),,446828-20$7:798:7'2:669.:328.3+.5.7.45623.1500767254466185.0(520-34.63.4937(0856'5)86548474%,5::955///799+1-.2-:07916.8/775%-:559;6;::6619977798:81:76:.2+/1)7887,75966'5948:3535:4:9:5::9899)3;59.3:4778918:/4(-.'98;995+3',9197&97:787::-53:912,86'.-20%/38.9226.3/39)49468/94745-+'81302:;66275:6::592999074:5254.).530:4/-6.+8344:8::958:-1595.6.759666-7532)9*-'98:77-:97454$7$1,5:89436/605;8::758:4516863'33&78+65/)*4:977-7:9:3:6447:9587;93')*'9867:9543&(6/933878;:::7:98:::-/8289:8::8:42.94316345,2514/59455.33/644524&./'#,+&3598265434+4.8:641714/1,,0.45/19%24:/&(/.4.37641+0)8,976384'44&9)282-1)678;632;9-83'-)-&1:56:66524.86943,-,(0//-/13%/53778460852-1*6579005/,752*3*44.6-1056-7625)93/$072-49898846.96-2359878&'-106;7:84/(,83-0967-;69475:2*:9264536-3969757578889*88,574/20%)/,321'5779:9.8.35335896997844:780;30:3/&/749:99549887963-6379(68566653684:.7737/4./844:75.2.:2923.04:452/52,7*9::91:9;;43+43047*.2&:08%669%6751678597-5(&4./.847(/1&:-6&+843,*'02..(6'8866739::8-4+27::97':44587*96/89479)8769539;:73:2679769689349:/98/;9888:6*24464*6&7;:59576.(595644*,%5577,52:9717769464759-,::90-;2364680:6670*-607658-9361+6:7/544,2708,57-2735.285:8:;8663,(9:4.4.026/741*8677:6363799::559476948948:::6;766-9410443,077&3996558:093:857%80;33).4:4.24:595433-/1-200/527$68298:4:.472,/-65857269*887+54747578:9.5.595:7979;8600635963::678.7944447::4097788*944.4377977-/2&9;175249589:24:35447,9652945967228+,985%87:::8791056:69677.0-(;4116:964/3'081.9414885:7437:507;6684'62656/63323329:1)32*9856:883985-059:7:76;489174145913;4638::91:96715::248/:998/24551&8:773439,897/4761019:85937.76784556.8938857/938*6564+8%%103+69698139136:95868-:499::9246-4-09:9143(26/32(/5481/75-455839477799,0383121/428'995:::;7:6.2037/4/:'.*779-542(340+62:104/521%082-476/.269 @rCer/463/24_2016_CCS ATGGGAGACCATCCAAGAAGACAGTGCAGCCACCTCCGAGAGCTAGATGTGATGGCGTCACAGAAGAGACCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAGTACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGACTCCATTGGGCGCTTCTTTGGCGGTGACAGGGTGTGCCCAAGCGGGGCTCTGGCAAGGACTCACACCACGCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGGACTCAAGATGAAAACCCGGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACTCCACCCCATCGCAGGGAAAGGGGAGAGGACTGTCCCTGAGCAGATTTAGCTGGGGGCCGAAGGGCAGAAACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGAGTCGATGCCCAGGGCACGCTTTCCAGAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAACTTAATCCCATTTGCCCCCATTACCTAGTTAGAGCAGATGACCTCTCCCTAATGCCTGTGGAGTTGTGCACGTCCTAGGTCAGGCACACGGCAGCCTACCGGCAATTTCTGGCCAACAGTTAAATGAAGCAAATGAAAACAGAAAACAGTTCAAACTGTCACTTTCTGTGTGAAGGTCACATTCCTTACCCACAGTGTGCCCCAGACGCTCGTGGGTCTTCAGGGGCCAGGTGCACAGACGTCCCTCCACGTTCATCCCTCCACCCTTGGACTTTCTTTTCGCCGTGATGGTGACACCCTTGCGCTTTGCTGGCACTGCGATGGAGGCACACAGCTGCAGAGACAGAGGACGTGGGTGGCAGAGAGGACTGTTGACATCCAAGCTTCCTTTGTTTTTTTTTTTTTTCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGTCAAGGAGTGGCTTACTGCATGTGGGAGCTTTTGGTATCGTGTGACACATGCGGGCTCCACAGGCAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAACAGGCGGCCTCTGGACGTCACTGTTGCCCTGCATGGTGGCCCCAGAGCAGCCTCTACGAACAACCTCGTTTCCAAACCAGAGCCCACAGCCGGAGAGTCCAGGAAGACTTACGCACTCAGAGCAGAAGGGTAGGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGCTCATCCACCTCCTCCAGAAGACGCGTCGTAGCGAGTAGGCACAGGCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGATGGCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACCTAATTCTGAATGTTTCGTGTGGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTT 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rCer/464/25_2477_CCS ATGGGCGGAGGGGCGCTAGGTTTCAAGATGGCGGTAGCTGAGGGTAGACCGAGAGGCCGAGTTGAAGGCCCTTACGAAGTGAAAGAGGCCGGGAATCGCCCCTGCCGCTTCTCGTAGTCCTGGGAGCACAGCAGAAGTGTTTTTCTTTTTTAATGAACAAGTAAACCATACAAATTGTCAACATGGGACGGAGATCTACATCATCCACCAAGAGTGGAAAATTTATGAACCCACAGACCAAGCCCGAAAGGAAGCCCGGAAGAGAGAATTAAAGAAGAACAAAAAACAGCGCATGATGGTTCGAGCTGCAGTTTTAAAGATGAAGGATCCAAACAGATAATCCGAGACATGGAGAAACTAGATGAAATGGAGTTTAACCCAGTGCAACAGCCACAATTAAATGAGAAAGTACTGAAAGACAAGCGTAAAAAACTGCGTGAAACCTTCGAACGTATTCTACGACTCTATGAAAAAGAGAATCCAGATATTTACAAAGAATTGAGAAAGCTAGAAGTAGAATATGAACAGAAGAGGCTCAACTTAGCCAATATTTTGATGCTGTCAAGAATGCTCAGCATGTGGAAGTGGAGAGTATTCCTTTGCCGGATATGCCACATGCTCCTTCCAACATTTTGATCCAGGACATTCCACTTCCTGGTGCCCAGCCACCCTCTATACTAAAGAAAACCTCAGCCTATGGACCTCCAACTCGGGCAGTTTCTATCCTTCCTCTTCTTGGACATGGTGTTCCACGTTTGCCCCCTGGCAGAAACTCCTGGCCTCCCCCTGGTCCACCTCCTCCTCAAGTCGTGCAGATGTATGGCCGTAAAGTGGGTTTTGCCCTAGATCTTCCCCTCGTAGGCGAGATGAAGACATGTTATATAGTCCTGAACTTGCCCAGCGAGGTCATGATGATGATATTTCTAGCACCAGTGAAGATGATGGCTATCCTGAGGACATGGATCAAGATAAGCATGATGACAGTACTGATGACAGTGACACCGACAAATCAGATGGAGAAAGTGACGGGGATGAATTTGTGCACCGTGATGATGGTGAGAGAGACAACAATGAAGAAAAGAAGTCAGGTCTGAGTGTACGGTTTGCAGATATGCCTGGAAAATCAAGGAAGAAAAGAAGAACATGAAGGAACTGACTCCTCTTCAAGCCATGATGCTTCGTATGGCAGGTCAAGAAATCCCTGAGGAGGACGGGAAGTAGAGGAATTTTCAGAGGACGATGATGAAGATGATTCTGATGACTCTGAAGCAGAAAAGCAATCACAAAAACAGCATAAAGAGGAATCCCATTCTGATGGCGCATCCACTGCTTCTTCACAGCAGCAGGCTCCACCGCAGTCTGTTCTCCTTCTCAGATACAAGCACCTCCCATGCCAGGACCACCACCTCTTGGACCACCACTGCTCCACCATTACGGCCTCCTGGGCCACCTACAGGCCTCCCTCCTGGTCCACCTCCAGGAGCTCCTCCATTCCTGAGACCACTGGAATGGCCAGGACTCCGAGGGCCCTTACCCCGACTTTTACCTCCAGGACCACCACCAGGCCGACCCCTGGCCCTCCCCAGGTCCACCTCCAGGTCTGCCTCCTGGTCCCCCTCCTCGGGACCCCCACCAAGGCTACCTCCCCTGCACTCCAGGTATTCCTCCACCTCGTCCTGGCATGATGCGCCCACCTTGGTGCCTCCCCTTGACCTGCCCCCCTGGCTTTTCCCACCAGCTCCCTGCCGAACCCTGGGGTTTTAAGTGCCCCACCCAACTTGATTCAGCGACCCAAGGCGGATGATACGAGTGCAGCCACCATTGAGAAGAAAGCCACAGCAACCATCAGTGCCAAGCCACAGATCACTAATCCAAGGCAGAGATTACTCGATTTGTGCCCACTGCACTGAGAGTACGTCGGGAGAATAAAGGGCTACTGCTGCTCCCCAGAGAAAGTCAGAGGATGATTCTGCTGTGCCTCTTGCCAAAGCAGCACCCAAATCTGGTCCTTCTGTTCCTGTCTCAGTACAAACTAAGGATGATGTCTATGAGGCTTTCATGAAAGAGATGGAAGGCTACTGTGACAGCTTTTGATGCCAGAACAGGCTTCTGTTCACAACAGTGGCCATGGAGAAAGAAGCTCTTATTAAACTTAGATGAAAGAGCTGCTTCATTGTCAGGGTATTTTCTAATTCAGTTCAAGGAATATCCTAAAATTTAGCCTTGTTCAGAATTTACTGCACATAAAAGAGGGTATTTCATCCAGAATAGATCAGTTATTGAAGCAGTGCTGCTAACATCCATTCCTTTCACACCACCATTTTCATCCTGTTTCTTCCCTCCTCCAGTTCTTTGGAAATTTGTGATCACAGGGGATCTTAGTTGCTTACTTGTTTTGACTCTTGTGTGCTGTGGGCACTGGGTAGAGATTTTTGAAAACAGTTTATTTCAT + 3+(=<<:=;*7:;=>;:8+3,78:8:62;>1>;;647<7;2;*;:<87<47?><<5==<47;)<(:08;:2/*;7;)0$98995584=19>:8=:/:<<68<:=;<185=4>9&9950.*:8=<<;;::2:20:983<<9=;56>6<;7>5=9(4;;7-877;;=<4787953<;;9;/::;99?8:6099+79:8:>5?;;;$7752;7;38*=719051?>9;7=.2=?3;=8=>;=>:<:88??<5?=2:6&58:;;=<=8=?8=;:9:?4;>=>=886687*4:55/86=692779$:812:.676/<;::;965/,42,*68;;595=:3=67*4.83908:2>?><;;6'5.786;==6?9?8?=338438:81.6-829=<9927:4<:)<<98994==:;889:1<7;:;>?:57:7<77=>9<>>;?>:;%548555617/-:486:=:??59::>=8;.:96046;:88759=<8=>99<96=3<<<<,97/$:6<80:57>;>%.3>:<5;8?;45=::968-=7%35789=2<88<::2;076759:461520;*1-7=7-9083376=,;5;;36497:44&/-<<=%<9=.2:-387<5=:378?57;=(;82;8;1;9<=2:11==5/202<<>7>>:0<;;5=>>:6;?67>1>9;?99:16479%64:;518>==0:=;5:08==>?98/9<077:<76;:7<:;=9:.'18?<:5;;9;%:&'89=61=?<=8:=:::(48588::;,::57==)469<4:=<83;3)/4222197:24;9>71??:<>::.47<<9;;->>==2;:8?37<;>;9&19;8=;?<::9582>599>4=<556;;:7>0>699/88;96=47<;77>=>;;;;2052,369+>738899345.98::9:6796%4821<<97>=:)>=86;>3:5===3;8=9><>;8;99&%0;<;:8699&31;:*;;;.9:19;;9:?31;>:=;666<4;5??98:;=457;)475=):89:72:35'6-%19999>8=?:8105>.<7?,;?;6;+>==:<>;?=:<>7:97)0558983478><-<27)::1528/:=9;<016(5/<-><3>48<<36;4;'1.52=8:8>7915335:83<><9838>46-94;=:7>>9;?>:9<36==<45=7=;:'<;64<;>;364;?785;19A$28?3B93=>>7C5<=508=B9???4?./@,<;>;68475&13.-5>38==:@><438<&:;=<<<:A3>=2;B:>??A.9;&@<:69-94,:5/>95A<277::A6A@.::-78&9??<<@=(3.639=59:@@1<=6>?&69782:?5);:A?2BB@.,7'9;'24,96=?>9C==9=1<<2<;9>3>?==5=/25)87A;2;(/%46>=:3<=C=<8?>&835;919976=73;?;<3:83:56<<&;-'9;1@>3639=4&5;:31=+541)5;76)+-7CA97<.<88;>;>0+43)44-99&<644=/7;=):90.8;:=3792%57A@/@=A/?*787?A8>49962B@4=<334-768:2==912':--4:/::(6><8:+.2920'427897)8329722>95*4+8940;2%/33/.6+535&799,>>:79;>2'2147164';90>;<8?:39::=(340<-99881<=3>:>;>=;>>8=4<4)81=9>>>55=84;69-;;9358/68*436;9108<7:<8*72>;3/:>78086'0218::08836;3:/5:+31=2>?=88>7==9>=:2):<:<85:7:;86<.=4477<25;=1:34?=:<=::4?25:;11=36:36-29197/<766755?-38977<-.78./7=2;7:>>969<889>7&,:%4242569<:>:?=569=>4-2/::9;>96:79848')&*,#$+/3-415953;74=::8=/767*291813;:9934*870&+82,0346.032899><<85:=9>96/2/1122713'.398++25.383:6/7>3091=466996;(54>72798:75%7718:96967484272/1*.-6267738>;;27)5;:179+6839+135<68<<8'78:0,,)50478*<7;=-89-4>81:*==6?3=;<7?;<:?:09)9%9831+75=0:3=6071,7.=<4;=)953=725,76389/406772;:54569=>5:4;643<%6/351615/8969(+.1&(.1;11774.8722926/5;4*76:=69>:5<6:96813;=72980<44<>:'.6761;0--451;88;9671=<6.807088=95=88>7$99.0358=9?;-<1/0;0-3+88==:0**300,/515+*;779:;3>9+8#203886*4>32<:;8>:?262(6<0717?14=<9$66437<><=85:3>8,3:774@;2<<29/.==;;<4@708598385=;;>B?9%$7463584;39166;<@>>?<:69,B3-4;3:9234;:B6:9ABB>=>9*5/;;@B;/<<=/CB<<@.<:,7<59>B?><8-?7=48>8;<=>798;?.9?9+<7;3<=:689:A6B@6>664=>A3?<>CA77+8@-9259+2:;1;<:;>3<94<=9<5:;:,@;7A=&8986314:5;937?>9:>=8?:44<76A=1<<7A65=A=1:A::3:<;A46;B3&&'64/>8:/98469:/46,-+1?>5(#8527/<76'95.1?;988<<<65280<'57(6@/33777*''3.8-88;8:=59>.5:=9:876,55996>2:=<7;B6BABC>;9+<;>4<6<3:@:064>98=476=B;,;9:742*A4:9137:58C8:;E@?4>AD=C>==CF2@E?7AD@DF;DD??;<%+>3;5:ED59=G6?A<>ABAB;?%=76AD8B;:@ACBC:>?<25&3@EDFBEFF<;AEEAFAEA<%19A<9?:>B=BF=F?18>B::0=D:CB2F@<'7DD7AAB<@;?BDF@C@DA=C3C1:8@=AAG8=-CCA:8;2D>C>EDAFAB;:34052<>=1205888:@EA;A7CDD:B>9;A3?=/?,69>AE$CB4>1@2>A<)7;;A.:A?AA=>;EBEA?@2C?@1>>E=>A4;17578@@9*569:72>E?C?>1@<>9BBA9??5;C;+851?9=&<:>9D1DD??CCD@?59<>3DB8B?CA:;,;4CA7=@8@AE@:?*834@.?;1731;=;@ABA@A::<@@>=8>==&;<566<8=;==?BBB:->%6*1<<@6>6(=9<=<&79379=6>B???=:A-07>=::>59;<@B;?7=:>;;=7?C6<%?9&;=.-5<7183@KEKE;HGC&JKEK@IIK>JKKKKKICKKBKKKKHKKJKJBFKHJJKIJIKKHKK6KJKKEH@KJGKIJKKHG:JIC;KKHKKKEJKKIHKKHKKKKDIJK'FCCHJ2F?HFGAJIJ;HH9BJDEGJDGJJDIDKFKJKIKKIKEDJKKFJKJJKIIKJ4KGJJKKKDFJ.JJHEGKKHCIKDKHHKHJKFICJ9KKKEEH5HHKE.AGH>IKJJDJGIEEHCJIJ=?:KI4GGBIHJJIJGJJJBGJJAKIJJ?IK=KKGKGJKKIKK>KEFJCEJKAJ=KKJJIJGJKKJJK6JJKHFI5HJJJIJAKKEIKGHGFKKJKKDGKGBG:F@IEKKKKJGKJKAKJKIKKKJKIK:GKKHKKKKJKK@KHKKKKI=KJ4KKIKFKJICKKKKJIGKKDKJIKJDKHJJCKJFGKBKE@KGIDKKKKKKIJJK9JKJCKKJ>IJKJKKKJFHKIJJKAHIJIIJ?JKKKEKFKKKJKHKKJKJGKFBJAKKEGJIJKIKJ?IGJJHKKJIKKIFK%GGJDGGIJKKKFKKKGK:FDJHKKKFGIKCJJFIKKKGKKJJGKICJ/@JEKKKIJJGJGKJGF?KHKCKIIKDEKEKJJ;DFIFB?HD:HKJGKDK?KKJGEGKF?J4HKJIG9F9JFJKKAKK3BJDGJK;KIKJKKIKJIGJKKJKKKKKKJDJJ@GC/J>=DF/KIIKKKJKKKIKEKJJJJIJJ=0JKIJJI+K:K?JIICJHIFKCDKKKKKKJKJKCKJGKBJJIKJ>KJKDJIK2KKIBJKKKKKIKJ7KKIFJJIIAKKJ@KKGIFH=HGKGKIJJGGFD>?0HHJJIKGJBKIKJKHIKFKKJKKKIFKKFJJJJHK?KE/KKKEKJJ=KKKJJKHIJ@HHFBKDKKJFKKIHKGKJIEKKKKKKGKKBKJKIKKIGKGG9KKKIJ:AJKKKKAKJHKKKFKBJKIKKKIKJAA=KKKHHKJKJI?KKJ'KEEIFKKJDKCG@GGHKKHK?KDKKKKJKIIK@GG?HHKKJJ+KKKGKKKKIK*KFKK @rCer/467/751_60_CCS GGTAGAGTCCTCTGGACAGCCTCGCAGCCGCGCCAGTCACCCTTAGACACTGGCTGTGACCGGGCGTGCAGGCAGCGGCAGTGGGCACAGTGGCCAGCACTTAACCCTCCCTGAGAAGATAACCAGCTCATCCACCTCCTCCCAGAAGACGCGTCGTAGCGAGGTAGGCACAGGCGTGCACCTGTTCCCGAATTACTCACCGAGACACACGGGCTGAGCGGACGGGCCCCGTGGAGACAGAGAAGAGCTCTTCTGACCACATCCTTCCTAACACCTGCTGACATCTCCTTTTGCTCCTCCCTCCCCTAACCTACTGACCACCTTTTTGATTTTAGCGCACCCGTGATAGGCCTTCCAAAGAGCCCCACGCTGGCATCACCCTCCCCGAGGACGAAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCCACTCTAATCTGAATGTTTCGTGTGGCTTAATATCATGTCTATTAATATATAGCCTCGAAGATGAGAGGGTTACAAAAGAACAAAACTCCAGACACAAACCCCCACATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCCATCCATACGTGGCCGCACCCAAACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTCCTGAAATTGAAATAAAACAATAAACTTT + /&,%$&$$)%((%0-0/(0--,&+*'(+)--111,*&0/220/'/((&,,-211/%%,/1*+/*-+()*-1,,+)-/',.)(&)$*-++$*1,60,/0.*)%-)-,%)))#'.,150,+-1/,$*++&00.53240+1.0/4*-40(%*,10211-.((.%,.(/1503,'#)&,2+5../1&/)*20(-(-4/(-12/641.,'&,&/0',&//1&447')8;2);:9,45.'949:666-6462:437?=;<61::-258?;81502602+4167+68.61254-$721$:4861072,6,*5%0/*2,,)79:-9'2=;714.%1+++.*&-,,+.10//.//-0/.2,*,2.6.3+24484*4559043/0-3)11*1-22'5:9-964:.&.4+/2(743+6,097-*.'//.8155/$437.4.+.9:,3.04/0402/%2(%1/0.1/47522)+/12$,4-7,4104*06:0*33.3-168:679<472882783..2<91-3)41*33';4<3534+--8&+%23//13$5256.6/39-18.>8844,8':72899/89=/69936469*128.;>99=:4662*37:590.573:79568-7>98/)*/.==6:0953+9/072(05174:<-=884(.520)031875,(:<=AC4/:148;/1?>7-2./,9A48<5& @rCer/469/1634_95_CCS GAGAGAAGAAGCCAGCTAACTAAGAAGGCAAATGTAGGCACAAAATACAATAAATTGGTATAATTGGAACCAGCATTTGAATTTGATGTAGAGCAACATAACGTAGAAGGTGCCTATTAACATAGAGAGACTCCTTCATGAATTACCAAATAGAAACTTCTGATAATACATACTGTCATAATAAAATAAAGGAAGAAGGAAATATATTCTAGCATGGCAGCCACAATGCGAACCATCAGGATGAAGAGAACTTACCGAATACTAACAGTTAGAGCAATTCTTTTCCAAGAGAGTGAATGTGGCATTATTAAACTGGGACTCTAATATAAGCACCAGGAGGGTGGAAACAAAAAATGCCACTGGCCTACTGCTCTGAAGAGCAAAAACTTGCTCGTCGCTGCGAGGTAATCATGAATTACTGAGACGATCCACATATCCACAGAAGTGCCTCTTGGTCTAATGGACGAGAGAAAAGAAATAAAAATGTCTCCAATTCCTCAGTTACCAGAAGAGGGGAGAAGGTATTGCCCATAAAAAAGCATGTAGGATGGTGGAGAAATAGATGGTGGGAGAAGAGAGAACAACCAATAAACATTAAGTAATCATGTTTAAATAAAGATATGGGCTTTAGCATATTACAAAGTAAGAGTGTAATGGAAGCCAAATATTAATATTGCATACAAGAAACCCATTTCTCAGAATCTTAATTTTTATTTTTTTTTATTTTTTATTTGGAGACAGGCATCTACGTTTTCATAGATACCTAGCACACAGGACTGGGAAGATGCCATTGGCGCAACACTTGGCTCACCCATACTGCACCCGTGGGATTCACGAGCGATTCCTCCTGAGCCTACAAGGCCTCACCGGGAGTCAAGCTTAGACGTACAGGCACCTGCCACCACTGCCAGCTAAGTTACGTAATTTTTAGCTAGAAGATGGATATATTCAACCATTGTTTGGCCAAGGAGCATGTCTGGAAAACATTCCTCACCTCAGCGTTGAACTGCACCGCACTACGAAGACCTCCCAAAGTGCTATGGGATTAGTAGAGCATGAAGTAATTATTGGTCCCACAGACCATCAGAAAGATTGTTTAATCTTATAGAAACTACCACTTTTGATAGAGAGGAGAACAGGGCACTCTTGTAGGGGCAGCGCCATGTCCGAGGTAGATTGGTCTTTCACGCCTCGCTGCTCTACCTGCTTAAGTGAGGAAAACAGTCACTAGCAAGACAGAGAGATTACCTTGCTGGAGGCCGGTGAGGAATCGTGGCACGACCAACTGCCACCATACGCAATGAGCCCAGTCTCATTCGGGAAGCGTCTGAGATGCTCAAGCTCAGGCTTCTACCACAGTTTCCAAATCCTTAGGCACGAGGAGGGCTTATTCCGACACACGCTGGCTGTTGACTCTTCTGGCATGAAGAATAAGGAAATGCCATCACTCCTGCCAGAGTTATGAACTTGGTTAACAGATTAATTAAAATAAAGCCTGGTATATGTCATTGTTAAAAAAAAAAAAAAAAAGAAAAAAAG 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%*%",,#-"%.&-..)&"#--)"--#.('-%**-,"-%")"*,+$-#$"*&'&".'-+&"+$"#%&)#+,+&""$-%&.#,$&(&.&..$....%,"-)"+"..(-'-.*..*..//*)()..-./-/(...-..*.$.-"#,#%-&(),+#'#'*"&+&&'#&%%),-$-".+#,.()-#))#&(+#$#,%"*,-%-'"*+'/-/.*/.#/,$-.%"'-*,#&"--#$.('.-///#.*$/."--#)$%!.'#-%.."..-%%-..#.%.-.-"(".(".'++,,,.."+,-.-%./...+-#.).&"'"#,&+(#')%(*"##).'-..--"-.(+"&$,&%+&+-%##&"-./*--#"/)+,.&,.&..../),-..*#"*(+.,$(,-".$*-$,+$"""&."-&."...$))%..."%&,"#-,&&-.$(.-+..-/',)-(''-,,$,&"+$$,,-',&+$)"'#!"#*)%%*#"##"--,,&'&&*.$,--,.(.),-&,-.#-+,)(&.(&#&$-,*"%"*+",,(**+...*/...#*(..*-.),,-('("""%-)$-&+",+$---,-(+%&)'%#&+"%,*.-%%...-%/,//-/),/*.//+,.#../*#+-.'("/$/.#.)"-"+"'.."--#/..-+*.+/,-(.-+//%+*/.//-*/('*.-#...$%,,+..%*/.)-/.-/,.(""-+**"$-(**'%*%*#-*)%++#.+,-++)..).""%,.+#...$)+-$+".(."-)!(#-","-./*#.-.)#+$&#--%"+"*.*-.-''$,,%+.*-.,%+''#("...+".)+$&&-("*',.""--+//.)"-++-&."#+-.$--".'$-,,",+-%#.-.""-..-%....#,---/*'.-$&&%+--,&%..*&-....+,/*./..#--('**&&"),+.#..&.*"%-%.,$'$%%-..%..)%.**("-.)#".$...-..*"(',.#.%-.../....//&,.'."%--/,".,/,"--"-#.#.(,-.,,*,%*,,.,-$#.%%//).#.--#*&+--$-+.(&.)#-*&!"+('%(,-",*$"-...*,//+).()"&,.,"+,.#..#,--"-,&#.'++.%),&#+#+'#*$&")-&(*....-#....*%(,...$,,$./.,&".,*-&-".(&&($++,..$/)--#"#%(#&*---$..%.*$..(.--(*$#&#..../*"-()%--*,$$-,--##--#+.((,)%&+#'#"-)%*$',.,.".,+%"."-.,,-,)..+*.""..%"..,-#).++#+,/#,-,#-%"-',&-#.*-#'...*.'%.&-%/..-./*$.)#$,",.+../''**+,,.++.)".*""$.),%"+*(..*#.+$,..#$,(*"$-"*"-",+."-.$-,+..#-#./.#-'"**+,#*&&.'*#+.-/).",..&../,(.#*/.+,--)"#.,.#.//..*.-.*/"$-.*+.-*'+/"+.,-'#$&--).-(('')&'&$&%'$%('(("*'$)')($ @rCer/471/25_1949_CCS ATGGAGACATTCTGCCTAGATTTACTAGCATGTGCCTTTGCCTTCTTCTCTTTGATGGAACAGGATGTTCAGAAGTCACGTTTCTGTGATGTGGTGGATTCCCACTGGGCTCTGGCCCTTTTCCTTTGGATCCCGTCAGCGGTGCCGCTCAGCGGCTTGCACGCAGACTTGCTGGGAAGAAATGCAGAGCCAGCCTGGGCTGCCCACTTTCAGAGCTGACCTCTTTAAGCCCTTGTGAGTGGGCTTCACCAGCTACTGCAGGGGCATTTTGCATTTGTCTGTGTCAAGAAATTCACCTTCTCAAGCCAGTGAAATACAGAATTAATTCATCAGGACTGAACGAATTTGTTTATTTCCCATTAGGTTTAGTAGAGCTACACATTAATATGTATCACCTTAGAGCAAGAGCTTTGTTCCAGGAACCAAATCACAATTTTCAGCCATGGAACAATATATCCCATGGGAGAAGACCTTTCGGTGTGAACTGTTCTATTTTTGTGTTATAATTTAAACTTTGATTTCCTCATAGTCCTTTAAGTTAACATTTCTGCTTACTGCTACTGGATTTTTGTTGCAAAAATATATCAATGGCCCACATGAAACATACGAATTGGATCATGATAAGCAAAATGAAAGAAATAATGATTAAGGGAGAATCAAGTGACTGTGTTACACTGCTTCTCCCAGGCCAGAGAATAAACTGTTTCAAGCATCGTCTTTGAAGAGTCGTGTGATGTGAATTGGTTTAGAATGGATGCACACATCCATGCACACTCAGGATACAGTTGGCCTAATCATCAGTGGGGCATGGGTAAAACTTAAGAAAAGTTTCCTCATGCCAAATTCTAATTTTCTCTTACCTGTAAAGTAAAATTTAGATCGATTCCATGTCTTTGTTAAGTACAGGGATTTAACATATTTTGAATATAATGGATATGTTGTAAATTTGAACTTTGAGGGGCAATACTATTGGAATTATGTGGATTCTAACTCATTTTAACAAGGCAGTCTGACCTGCATAAGATCACTTGAATGTTATGTTTCATAGAACTATACTAATCTCACAAACGGTCTATAAAATATAGTAGTTGAAAAAATTTTTGTATCAAAATGTTTGGAAAATTAGAAGCTTCTCCTTAACCTGTATTAATTCTGACTTGAATTATTTTCTAAAATTAAGAGCCGTATACCTACCTGTAAATCTTTTCACATATCATTTAAACTTTCGTTTGTATTATTATTGATTTACAGCTTAGTTATTAATTTTTCTTTATAAGAATGCCATCGATGTGCATGCTTTTATGTTTTTCAGGAAAGGGTGTGTTTGGATGAAAGTAAAAAAAAAATAAAATCTTTCACTATCTCTAATGGCTGTGCTGTTTAACATTTTTTGATCCTAAAATTCACCAACAGTCTCCTAGTACATAAAATAGGCTTAATGACTGGCCCTGCATTCTTCACAATACTTTTCCCTAAGCTTTGAGCAAAGTTTTTAAAAATACACTAAAATAATCAAAACCGTGAAGCAGTATATTAGTTTGGTTATATACATTCATCTGTAATTTATAAGATGCATGGCCAATGTTAATTTGCTTGACAATTCTGTAATCATTAAGTGATCTCAATGAAACATGTCAAATGCCTGAAATTAACCAAGTTGGTGAATAAAAGTGCCAATCTGGCTAACTCTTAGACCATACATACTGATAGTTTTTCATATGTTTCATTTCCATGTGATTTCTAAAATTTAGAGTGGCGACAATTTTCCTTGCTATGGGTTGCATAAGCTTTATTTTTTCCTTTGTTTATAATTACATTCTTTGAATAGGTCTGTGTCAATCAAGTGATCTAACTAGACTGATCATAGATGAAGGAAATAAGGTCAAGTTCAAAACCAGCCTGGGCAACATAGCGAGAACCTGTC + KK%KJKJKKKKKKKDKKKJKJKKKKKKKKKKKHHKKKKKKKKKKI?KIKIFKKKKKIKKKKDKKKIKKKKKKKKHKKKKKFKKKKKIKKKKKKKKKKKIKIKKKKK;KKKKKKAKHKK;KKKAKKKKHKKK>KKKKKKKKKKKKIKKKKKKKKKKKJKKKKKKKKHKKKKKKK7KKKKKDKKKKKKKKKKKKKHKKHKKKKKIKKKKKKKKKKKKKKKI;KKKAKKKKKFKKGKKKKKKKKKKKIKKKKKKKKKKKHKKK=KKKKHKKKKKKKIKKKKKKKKKJJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK0KJKKKKKKKKKKKKKKKKHKKKGKJKKK4KKK8KKFKKKIKKFKJKKJKIEKKKKKKIKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKK9KKJJKGKKIKKKKKBKKKKKKJKDKKKKJKKKKKGKJKKKKKKIKKIKKKK&KCEKKKKJ>KKKKKKKKKKKKKKKKKKKKGFKKKKKKKKKJKKKJKKJKKKAKKKKKKKKKKKHJKKKJKKKKKKKDKKKKKIKKKKKKKKKKEKJKKGIKKK5KKKKKJKKK7KKKKJKKJ@KIKKIK=KKKKKKKJKKKKKKKKKKIKHKKKKKGKKKKKKKJKKKGKKKKKJKKKKKKKKKKKKAKKKKKKKKKKKKKHKKKKKKKKKKKJKKKKKK7KKKKKKKKKKKCKKKKKKKKKKKKEKKKKIKKKJJKKKKKKKKKKKKKIKKKKKKKKKKKK@KKKKIKKKKKKKKKKKKKKKKKKKKKKKK2KKKKKJKKKKFKGKKKKKKKKKGKJKKGKKKKKKKKKKBKKKKJKGKK0KKKKCKKHKKKKKKGKFKKEKKKKKIKKKKGKKKKKKKKKKKKKKJKKKKKKKKKKKKKIKIKKKKKKJKKKJKKKKIKKKKKKKKKKJKKKKK(KKKKKKKKKKKKKKKKKKKDKKKFKKJKKKGKKFKKKKBKKKKKKKKKKKKKKKKKKKIKKKKKKKKKKJKKKKK;KKKKKKEKKKKJKJIKKKKKJKKKFKKKKKKKKKKKKKKKGKKKJBKKKIKKKHKKKKKIKKGKKKKKKKIKKKKKKKKKK6KKKKKKKKKKKKKK9KKKKKFKKKKKHKKK;KKKJK5KKKKEKKKKKKKJKKKKKKKKKEKKKKKKKEKKKKKHKKKKJKKKKKKKKK@KKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKFKKKKJKKKKKKKKKKKKFKKKKKKKKKKKGKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKJKKK@KKKKKIKKKKKKKJKKKKKKKKKKKKJKKKKKKFKKKKKK5KKKKKKJKKKKCKKKKKKKKKKKKKKAKKKK.KKKKKKKKKKFKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKJKKCKKI2KKKKKKKKKKBKKKKKKKKIKKKKKKBHKIKKKKKKKKK>KKKJKKKKKKKKKKKKKIKHKKJKKKIKKKKKKKJKKKKFKKKJKKKJKKKKKKKKKKGKKKGKKKKFKKKKKKKKKKHKKKKKKKK=KKKJKKKKBKKKKKKKKKGKKKJKKKKKKKKKKKKJKKKKJIKKKKKJKKKJJKKKKKKKKCKJKKKKKKKJK:KKKKKKKKKKKKKKKKKFKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKKKKJKKKFKKKKKKKKAKKJKKKKKKKKDKKKKKKKKKKKIKKKKKKKKKKKKKKKKKKKKKK'KKKKKFKKIKEKKKKDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK@KKKJKKKKKKKKGKKKKKKKKKKKKKKKIFKKKKKJKEKKKHKKKKKKKKKKKKKKKKKKKKKKFKJKKKKKKKKKKKKKKKKKKKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKGKKKKKKKKKKK?KKKKKKKKKK5KKKKKKKKKKKKKKIKKKKKIK @rCer/472/2366_58_CCS ATGGGGGGGTTGACGGCTTCTGGCGGGTGGCGGTGTTGAAGGCGAGAGCTCGCTTGGCCCGTGTCGCTTCTGTCCCAAGAACCGGACGGAGAGTGAGGGCACGAGGGTCGCTGTCGGGGGCTGTCGTCTTCCACGTACACGTCGTCGTGAGGAGCGCAGTCCGGACTCTCTCGCAACCCCTCCGGCTCCCTTTCCGCACGCCTCGAGGCGGCGGCGGCCACCGAGACAGCAGCGCACCTTCCCCCATCCCTTCCCCTTATTCCCCCGCCCAAAAGGGCCCGGTCTGCGCCCCACCCCCGCCCGTCCGCCCGCTACGCCGCCGCCATGTCGGCGCAGGCCCAGATGCGCGCGATGCTGGACCAGTTGATGGGCACCTCCCGGGACGGAGATACTACTCGTCAACGAATCAAATTCAGTGATGACAGAGTATGCAAGAGTCACCTTCTCAACTGTTGTCCTCATGATGTCCTTTCTGGAACTAGAATGGATCTTGGAGAATGTCTGAAAGTCCATGACCTGGCTTTAAGAGCGGATTATGAAATTGCATCCAAAGAACAAGATTTTTTCTTTGAACTTGATGCCATGGATCATCTGCAGTCATTCATTGCAGATTGTGATCGTAGAACAGAAGTGGCCAAGAAAAGATTAGCAGAAACTCAAGAAGAGATTAGTGCTGAAGTAGCAGCAAAGGCAGAACGTGTTCATGAGTTAAATGAAGAAATTGGTAAATTGTTAGCTAAGGTGGAACAACTAGGAGCTGAAGGGAATGTGGAAGAATCCCAGAAAGTAATGGATGAAGTAGAGAAAGCACGGGCAAAGAAAAGAGAAGCAGAGGAAGTTTATCGGAATTCTATGCCAGCTTCCAGTTTTCAACAGCAGAAACTTCGAGTCTGTGAAGTCTGCTCTGCCTATTTAGGACTTCATGATAATGACAGACGACTGGCTGATCATTTTGGGGGTAAACTACACCTGGGATTTATTGAAATAAGAGAGAAGCTTGAAGAATTAAAGAGAGTCGTAGCTGAGAAGCAGGAGAAAAGAAACCAGGAACGGCTGAAACGAAGAGAAGAAAGAGAAAGAGAAGAAAGGGAGAAGCTGAGGAGGTCCCGATCACACAGCAAGAATCCGAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGATCTCGCTCCATGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGAGAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGTAGCCGCAGCCGTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAGAGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTCAGAGACCAAGACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATCACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCCTATGAGAGTGCTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGAAGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCAATCCTTAAGCTTCCTATGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGCGACAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATGTACAGTATCTAACTTTATCTGAACTGAACCTGTTTTCCTTGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGTTCTGAAAGTACAGTTTTATATAATAAGATGCTGATCTCTTTATTCTTTCAAGTAAGAGTGATAGTGAACAAATTGTGTTACTTGCCTTGGGAGTTTTTGAACGTTTGTAAAATGCTGTCTTCCTAGTCCAAACAGCTGCAGCTTTGGGCATTTTTCTTTTTAATTCTTCTTCCTCTGACTTTGTATCCCTTAATACCTACACTCTCCAATTGTAAGAGAAAGGGGGCAGGGAAGCAATATAGCTTCCATTCTAAGGCTGTATTCCTGTTATGAATTACTAGCTGATTACAGTTCAGAGCATTGATCCTGGAATGTGTGCCGGAGAAATTTAAAATACTGGGGTTTGTTTAATGGTGCCTATTTAGAGTTGGAAGTTGAACAGCTGTTGCATTACATACTTTTGCTTTTTTATTGAAATTTTGAAATCAAACTTGTCTTGATTTTTCTGTTCTGTTGAATTGCTATGTTCAGGATGTTCTTGGGGGTGGGGGCAGGGACTCTTTTCATAATAAGCACTTGTTTTATTTTGTGTGTGTGGAGTATAAAGGCTACACCCTTATTGTAAAAAATAATAATAAAATGAAAAACAATCAC + IBKKKKIC(I7EKKKKJK@KKKKKKK)GKJIJGECH,JKHKJIEIKJJKKJKGKEKHKICBHHDKKKK>FIKKKJ8KJKKIKKIFDHJ@DKKJJHHJKGKIGKKKIGGKJEJHKKKKKK5KKGJCJJFK?KJIKJJEHJIKJJJCJKIKKGIKJIKKKKKKGKJJJK;GKHJJJKIKKK/JKJKIIIKK>KJGKKKKKKKKKEKG?JAKFAGIKJKKKKKJJJI9JKJKKKKKKJKKKKKKKKJJJIKI1KK?KJKJKJKJJKJJKFJKJ0KJKJKJIHKKKKHJJAJKKKKKKCKEFKIHGJKKDJJIJFIJJKJJKKKKKKKKKKKJKKJKKKGJIKKKJGKKKKKKIBKGIJKBKIK8JJKKBDKJKK:JKKKKDCIDA=;GIKDKKJKJJJKGKIDJK>JJJKBCKKKKGKKEEKKJJKIGKKKJKJIDDKIJKKKKKKKKKJKIKFKKKGIBJHKKJKK>JKKJCJKKJBKKKK1K?EHIFBBEKIKKK0KKJKKKKIKIEKKKJHHIKKIIKHJKEIKHHIEKEJ7JJKJKGHKJKIFGK?BJJEGJDHKGJKKEGFIHHHCFKKHHKKKKIK?JFIJJIKJJHIKIJKKIIFEJDKJKKIGKEJJFKJKIHH?DHDC1HKGKJ?>HEKHKJH?JKKKKKHIKJKFJKJJ8HKJKKKKJDJHJKKIKJEJDJJKHGJKIGKKKJKKKIJKJKJKKJEKJKKKKJKKKH=EDJKKKK7HKFHKKCKKK>HKKFKKKGDJKKKIKKBJHGJIK9KKKKIKKKK9HK@KIKKKKKKKKKKKEIIKKKJKFJHKK%DHKKK:KIKK@IFFJJKKJFKKJKK1KKKKKE?KKK@GJKKKK4KJJKJJ= @rCer/474/25_3042_CCS ATGGGGCAGTCGGACTCCCTCCCCAGCCGGCCAGTCCTCCCGGAGGAGAAGGCGTCGCGGAGACAGCCCGGGCGGGGCCTACCTTCCCAGGGCCGGCATCATGTCGGCGGCGCAGGTGTCCTCGTCCCGGAGACAATCTTGCTACCTGTGCGACCTGCCCCGCATGCCTTGGGCCATGATCTGGGACTTCTCGGAACCCGTATGCCGCGGTTGCGTCAACTACGAGGGCGCCGATCGCATCGAGTTCGTGATCGAGACCGCGCGCCAGCTGAGCGGGCGCACGGCTGCTTCCAGGACGGCCGCTCCCCTGGGCCGCCGCCGCCCGTCGGGGTCAAGACAGTGGCCCTGTCGGCTAAGGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCGGCCGCGGCCGCCGCGCAACAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAACAACAGCTCAACCACGTTGATGGTTCCAGCAAGCCTGCGGTGTTGGCGGCCCCGTCTGGCCTGGAGCGCTACGGCCTGAGCGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGGTGGAACAGCGCAGCCGCTTCGAGTACCCGCCACCGCCGGTGAGCCTGGGAAGCAGCAGCCACGCCACGCGGCTGCCCAACGGCCTGGGGGGCCCAAACGGCTTCCCCAAACCAACACCGGAGGAGGGACCCCCAGAGCTGAACCGCCAGAGTCCCAACTCGTCTTCAGCGGCGGCGTCTGTGGCGTCTCGGCGTGGGACGCACGGTGGGCTGGTGACGGGGCTGCCCAACCCGGGGGGTGGCGGAGGTCCCCAGCTTACTGTGCCCCCCAACCTGCTGCCGCAGACGCTGCTTAACGGCCCGGCCAGCGCCGCAGTACTCCCCCACCCCCGCCCACGCTCTGGGCAGCCGTGGGCCCCCAACGCCTGCTCCCCCAGGGGCTCCTGGGGGCCCCGCTTGTCTCGGGGGTACCCCGGGTGTATCGGCCACGTCGTCCTCCGCGTCGTCTCGACCTCTTCGTCGGTGGCAGAGGTGGGCGTGGTGCGGTGGCAAGAGGCCCGGCTCGGTGTCTAGCACAGACCAGGAGCGCGAGTTGAAGGAGAAGCAGCGCAACGCCGAGGCCCTGGCCGAGCTGAGCGAGAGCCTGCGCAACCGCGCCGAAATGGGCCAACAAGCCCAAGATGGTCCGCGACACGCTGCTCACGCTGGCTGGCTGCACGCCCTATGAGGTTCGCTTCAAGAAGGACCACTCGCTGCTGGGCCGCGTTTTTCGCCTTCGACGCGGTCTCCAAGCCCGGCATGGACTACGAATTGAAGCTGTTCATTGAGTACCCCACGGGCTCGGGCAACGTGTACTCCAGTGCGTCTGGTGTGGCCAAGCAGATGTACCAGGACTGCATGAGGACTTCGGCCGGGGCCTATCCTCGGGTTTCAAGTACCTGGAGTACGAAAAGAAGCACGGCTCCGGGGACTGGCGCCTGCTTGGGGACTGCTCCCCGAGGCCGTGCGCTTCTTCAAGGAGGGCGTGCCCGGCGCTGACATGCTGCCCCAGCCCTACCTGGACGCCAGCTGTCCCATGCTGCCCACGGCGCTGGTGAGTCTGAGCCGCGCCCCCAGCGCACCCCCGGGGACCGGGACCCTGCCGCCTGCGGCGCCCTCGGGCCGGGGCGCAGCGCCAGCCTGCGCAAGAGGAAGGCCTCTCCGGAGCCCCCGGACTCAGCCGAGGGCGCGCTGAAGCTGGGCGAGAGCAGCAGAGGCAACAGTGGATGGCGAACCAGAGCGAGGCGCTGAAGCTCACATGTCCGCCGGGGGCTTCGCGGCGCCGGGGCACGCGGCAGGGGGTCCGCCTCCGCCGCCCCCACCTCTGGGACCTCATTCTAACCGGACCACCCCACCTGAGTCAGCCCCCCAGAACGGTCCGTCCCCATGGCCGCCCTCATGTCGGTGGCAGATACTCTGGGCACAGCGCACTCGCCCAAGGATGGCAGTTCCGTGCACTCTACCACTGCGTCGCGCGGCGTAACAGCAGCAGCCCAGTCTCGCCGGCCTCCGTGCCGGGGCAGCGCCGCTTGGCATCACGTAATGGGGACCTGAATTTTACAGGTGGCGCCCCCGCCGCCTAGCGCCCACCGGGCATGGACCAAGTGCATCCCCAAAACATTCCGGATTCCCCCATGGCCAACAGCGGACCTCTCTGCTGCACCATTTGCCACGAACGTTTGGAGGACACGCATTTCGTTCAGTGCCCGTCCGTCCCCAGCCACAAATTTGCTTCCCTTGCTCTAGAGAGAGTATCAGGCCCAGGGCCACCGGCGAGGTGTATTGCCCCAGCGGTGAGAAATGCCCCCTAGTCGGGTCGAATGTACCTTGGGCCTTCATGCAAGGCGAAATCGCGACTATCTTAGCTGGGGATTTAAAGTGAAAAGGAAAGACCCTTGAACCACTGGGCAGCCACCTCCTTTGCCCTAGACCAGCTCCTCTCCAATCCTGAGGGCCCCTCCCCAACCCACCTCGACCTCCCTTCCCTCACCCCCAAGGTGTAGAATTGTGAATATAACAAAACTGCAAAAGTTAGTCTTATGTATAGACATTATTTTCGTCGTATGTTTCTATATTTGAAACAGGTATGTAACTTCTTCATTTGAAGGATAAGCTGGTTTGTGTTAAGCAGTATAATATCGGTTGGGTCATTTGCATCATATTCGTTAGCATTTATTGGTGGCAGAATGTTTGCCTAGGTACAGAATTAATAGCCCTTAGCAACGACTGCTGCTGGTGTGTATTTTTGTAAATGTTATGCACTCTGAAAGGAAACACACACACAAAAGAAAAATACTTTTTTTTTTTTTTTTTGCCAAGGCCAGTGTTGCTGCCTAAAAAAAGAAAAAGAAAAAAAAAGATGCTATAAAATGGTGAAAGCTTCCTTCTAACTGCCCCAAGTGTTGAAGTCTTCACTTTATTTTGTTCCGTTTTGTTTTGTTTTTTCTGTTTTGTTT + 5+$26671339-4,20/991&2558027183:7214:40:6-73/2&4580758462727398<5;2;9'47,%63/03+35732$59212:2:-71588:=;/02933:87==5;41/6413462;?==+4969=62)4<9118?6>=;>;;2:7=0;98959186?,;/?>0>8.,889128:<,;95960718,449576,/67775-:44:9=7;=99>;98?=78=;?=/<>::2<=71082617/56:;;:25033981<78=>8(59+6>0;7.:7=953-/>8=42:372=22>700?<84(5<8>><=>7:40;<:3.'578<>6:8;>8:5&9$89<>;87=948;4>/<2::;:5?=;?99:93;<><<8;77>>:<<5>5==>;>285-6;>><&88818+354,5+25577634737057689676*6+&*2485136-15/86.987:<19;7<:<=;:2/99+=7<78;0::7;:9,8-13964=4)6'6;3933*668906&766;8=/4<8334895156313082<4909:=;2=9:37;:1<73;82;;==6?;92>;;=9>:8:57:685:;:17>>=8551==8;?65<;:?<4-=?9-><&3)7::8/3289:75:38::6:6*6/147;::;5:85;;69:4;;-5794;558.80+-7564'8+-5;252463.89&(858986687497;59(4;84,75049'5-8:9-4/9826:89469:9157405:742*25,6540'74.37693/5-.6:/148862925453.-.02-618:*8654:90:9444&36.8999:41;958878#1-*//052979.865;::3/16.+.65399;:9;3;;7;4:24494:::7:438.%2,+5&%43635(03,/0042,(45836/692,:5(8883*804'35989*896:9.::835,41.1:96%457954;::3:9&8861/4&021,8653457924*658:4592,9.(-25256521)2/28:/0+88.27+2,130137+6.'88.1.%6232#0(1683754-61::0:,9:770565149(09866277*33-855344(05672:438;190.4:.*979.655'.0::91:57684:022-*(476936&.197)4'.//--4,%#**+23,:197(45186.690359479795&&(333587/9687/,2:559;5277/575574759829*8:::1993611;*488;913762-2.-%1655534',-.104*2*.,,22-,0120010,/3/43//0+31133,+.2-202/242111&12.0/1./15*2.-.2-430031011.26989118.7;644240-'.,2)0013*83686.759-179;3.2284-../2$'/39-2'(1)4)09749164.//-'4,)886-3471380-81.3.02,5:5/363,.45:-+24&977+2-28-&'2101&339;:1$4430&35634)63;40-/53077/8-/4294(5514564;66676955663465184;9950355823./5959048662.14.940*/430+1-//+12442+600/*.344:.4736/.5::8787:4/%/0/4)4545-3'443&2398.9687765029909823-5417%771:9631&465724:(-5340854&5652:-853-0:3314/95865694)'3-&--3'0245::865.4/231249/2'434-24.,+,1*-3867.7;798;997:39588725616523/3)+',14.%/04022&)2%-21/44739402-2&--56296499045/'76300*43.92-65.44/59:98.166.'2/23047)-603-5)1+22694499:24946230,(-'-132225133-2.0612&53403)11850988734986'3126953)+-*.*0)022-3,256447844,>82<4>52-5>:4.99=:.,6+7685*087::=<98'-+5449836/730:7949:6&9/*958::;9?8<7=8(1<>60/5=:::52619><;=?-;<92629886>78??;89;:83<'37545+3741=85)::7857:<2;28:87/504)6+9:73:1;;382:-421+4,>>:->=>03.:;=6:66>06:>=8:6:593<;1696;=6:9;;9&57/66*044$::.:=:814=77-662;0/8-89;;85,69573;=80<=1?==56?;7+<;:738:497:9%93168<*;:.987,;9503216)2/1&,&(9+792'<=-564:*:<=6%<12+*/49+=;:798'7:<<7*96<:(8686268:==5+><;4547<3809(619:27+8<4:;:6):8(<<;6'::;7=%0230<;584%7//+216+:8:62+79=91;442625,*1/877=9=:8:7::'570237:$:;9.-69><57<7=4:75885:*266+5=:7:-:396*/.72-+.,-&79:8=>=>9>75>=99>;0;:8?>;3??98<4>69:?*5(6<184335,3.78=:9911115:9:(0/>/6-'04)7;85&1123/,-+7,<52;;&+-,%3*;))87>=+9.5%::349<76>1<89=1>&8(88;8%63,<:3:)995617;.28354875880)#<<::52$06685852510-263:8>?9;/>;09<657432,1>85%754./56&395:====;7:::76:79+96/,*/=2&,5%94,=;=;757%1166,$2985:99856/11431.04:8:=;1(:=583;/;+7/+%66:7&533/7;>82:9/;:4/0:68;)91.+/69:798=>9;?;=17840%3:<;9;<=)57:>/== @rCer/480/2276_61_CCS ATGGGGGGCTACCGCGGCGGGGCTCTGCCCGCCTTGGCCCTCTGCTCTTCTCGGTCATGGAGGCGCCAGTCGCCCGCTTATTTCTGCTCCTGTTGCTCGGGTCCTGGACCCCGGCGCCAGGCAGTGCCTCCTCCGAGGCACCGCCGCTGATCAACGAGGACGTGAAGCGCACAGTGGACCTAAGCAGCCACCTGGCTAAGGTGACGGCCGAGGTGGTCCTGGCGCACCTGGGCGGCAGCTCCACGTCCCGAGCTACCTCTTTCCTTCTGGCTTTGGAGCCTGAGCTCGAGGCTCGGCTGGCGCACCTGGGCGTGCAGGTGAAGGGAGAAGATGAGGAAGACAACAATTTGGAAGTACGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCATAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAGATTTCAGTCATTGTGGAAACAGTCTACACCCATGTGCTTCAGCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTTGAGGGGAACCATTATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACCAAACTGGGGAACCCCACGCGCTCCGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTCCCTGCCTATAGTCAGGATACTTTTAAAGTACATTATGAGAACAACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAAAATGTGGACTTGAAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGTTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCCATCCGTTCTTTTAAGACCATCCTCCCTGCTGCTGCCCAGGATGTTTATTACAGGGATGAGATTGGCAATGTTTCCACCAGCCACCTCCTTATTTTGGATGACTCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACTCATTACATCGTTGGCTACAACCTCCCAAGCTATGAGTACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTAGACCATGTGTTTGATGAACAAGTGATAGATTCTCTGACTGTGAAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTGCACTACACCTATCTGGACACATTCGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTGGAACAGCACATTCAGGACATTGTGGTCCACTACACGTTCAACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTCATCATCTATGTTCGGCTGGACTTCTCCATCACTAAGGATCCGGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCTTGGTCAACAAGAGAATAGGCTTTACCGTCACTTTGACGAGACTGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAGAAGAGCCTGGAGACCGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGTGACAGAGTGAGCGAAATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAGCTCAAGAAAGACACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCCCTGTAGCCCCTGCCCGCATCCTCAGGGGGCCCAGGGTGCTTGCACTTTGCAGTGGCAGGCAGAATGGGTGGTAGTGGGAGGTTGTGCATGGAGGCCAGTGAAGGCTGACATCTGTAAAAGGCCTTCAAGGAAGAGAAACCAGGCCCTGCCTCAGGCAGTGTGAGAAGCTTGCTGTTTGTCCTTAAATCTTTCCTTTTTTTTAAAAAAAAGAAAAAAAAACCTCCAATTAAAAACAAAACATCTTTGTGTTTTGAACAAAGGAATTTTCAATATTTGATTGGTATTCTGTTCTGAAGCTAGGGTATTTTTTCAGCCTATAAAGCCCCTGTTTTATGCCCTTC + C@EEFB8,@AD97BA=7@BDD7C;>C>ACB>AF<;>@?>B3BAD6?GAFGDE=C;D8A5C@:@9;;BBCDAF;;<16DB:;:CBGFC>E9E@B;@<)?B?C?D>FCDCEC3B:;E:60'8:DE1?4D@>=<8>E@8C6>CCAE:@:;B>>=><;=B?4>AC;A>@CB968BA=;4*>4<.:A;=C=BA;@:7@8>4><65<9=AA6?;;>@@(A?>?9BA9A5?B0A@@==9ACB<@=@=?BCA@0@:AC@B@@A)A;?A>947A9:@A6A<7>6;?%8?<8+<=>=C@69<6*<><;9@A3==:>?>=?>=<,8.=??6>==8:;:<.:;8:;&?7A<=C=79>3>>B?A@A@?<>:A@=@3B><;:.:6:;41<B?CAA?A;2A6A=@<;)??:?@@C371=75:;86989=>?>4AB@;A@;:?6@B??:<<>@C=8<>3;<7@>B>A>>A>8.8A9>4?AB1AC;;8@:5>5:>>6C>A>6*50A@BA>@/@;;@A7649=>.9><<>B79>=?A@@+>A8;<;A@7?:AAACA>?;A>A?B:A3AB7BB@=>;?:6925A:=?>?A7A?@6;;388>?;8?B<<6=>>+32<6@;=<>;847.B<5A=:@@?;<<77-7>=>6B;88=>=CBA58761A1?:>6<21@BA@BC>CC@>A::(?1A=9?CACB;@A?>?A;@7=?A<=8:8462?=:?>AAA@>8@2;CC4C=A>>A?>?@:@A8B@<;>?>@A18.-8@=BAA>=AB?9?:B6A@,@<,:8@:=;<187>06:3/>::=9;>;58>;7=<>5<;82;<>>:;6<9?:*2=/>>5)8>>6=68=?;=/9?4>=:2;?=6:=)<>=;9<9?<<249:;6;=43)&%0:=:;187:=>868?<><>><564&=92=><2><>>>;9=?7<255;-7=884=659.;;2<9:?<;?=??7;>:;0244>;2=9:=;;=:9<75<99<4>;<75?5540916<::*9:6=?876355068;57<;?<>:=;=;8*:::3:68<+:33046:2?;<>428:?;8:=4<>6<6<>;6596:=>>:2;:5<>5<:>=7=<808>?=<=<:7:=562;<>4<3:0>:=>;>79<:?801<=4:72>==63>::59>=88,3;6=6<7?8<:>8826+9?:<;;-286=709:4%5928?:288=9:>1<5<::6<89883;9=:9;;8==8<;>643215<8=>68==;52;53>8=6<;;::1:;)6819:4?>>:5>957*7933.1,9;<7>>>8><=6=>;:6;;:=>=;5886'87777>>559?2==8>>=49::7>;59>913>7998;:?:>;;;;;?3=6=?376<;9=6;58<848><=?;859=<34;989>>>>968>:<8;><;997=<<69;<=6;<><:85:<4=<;7*77792;:=<3714,=5:8<;489;565>=>?=;49;<:(67<8;?<99=9;50=858:3;=85639%8;7::;?>;78;5:/077=;=9<=?<=7>=99:=7;<6;48:>?7:?=<4);>>;><96=1?4<<<>?>?>:>>=66>;>?8?<>8=<;/87<<5?9?;=>3>>8=83:6=?:>7?::>??;>:6;;9;2?;=76:>831;9386>;572<>1:7=?===>>**;859<;'=<=>>==>8*?>=;8?;:6;<==:5:88&9><9<;,>=;;9=/8?;7=52;8><8<<.>?>3>:<8=5989187:84>:<:4>;703308;=<===1<88>87:=3>9:8<=.897<:0<<877'=:= @rCer/483/1860_57_CCS ATGGGATTTTGGAGCGGACAGAGGCCAAGGCCGGCCGGGAAGCCGGACCTGGGCGCGGGCGCCGCGGTGACCTCCCTTTGTGTGCGCCTGGGTGTTGATTGCCTCCTTGCACGGGCTGCTCGCTCTCGCGCGCCCGCGCGCTCGGGGCGTTCTGCACCTGCTGGCGGCCGTGCCAGGCAGCCGGGCGAGCGAAGGCGCGCGGCGCGCACGACAGATGACTGGAGTCATTTACATGCTAGCACGTGGGTGCCGTTTGCTGTTGCCTCGGACTTCTCCGTGCTGTGTTCTCTGGGTGAGGAAACAGGAGGCACTTTGCAGCCGACAATGAAATCTTGGCAGCTAATTGCAGTCGTGGGAGATGCCCTTCAGGATATCAAAGCAGACTGCAATACCTGCGTGGAAATAGAAGACAGAAAGGTTTCAAGACAACAGATGAATTGTGAAAGAGAGCAGCTAAGGGTTTCAAGACAACAGATGAATTGTGAAAGAGAGCAGCTAAGGGGTAATCAGGAAGCAGCCGCTGCCCCTGACACAATGGCTCAGCCTTACGCTTCGGCCCAGTTGCTCCCCCGCAAAACGGTATCCCCGCGGAATACACGGCCCCTCATCCCCACCCCGCGCCAGAGTACACAGGCCAGACCACGGTTCCCGAGCACACGTTAAACCTGTACCCTCCCGCCCAGACGCACTCCGAGCAGAGCCCGGCGGACACGAACGCTCAGACTGTCTCCGGCACCGCCACAACAGATGATGCAGCACCAACGGATGGCCAGCCCCAGACACAACCTTCTGAAAACACGGAAAACAAGTCTCAGCCCAAGCGGCTGCATGTCTCCAATATCCCTTCAGGTTCCGGGATCCGGACCTCAGACAAATGTTTGGTCAATTTGGTAAAATCTTAGATGTTGAAATTATTTTAATGAGCGAGGCTCAAAGGGATTTGGTTTCGTAACTTTCGAAAATAGTGCCGATGCGGACAGGGCGAGGGAGAAATTACACGGCACCGTGGTAGAGGCCGTAAAATCGAGGTAAATAATGCCACAGCACGTGTAATGACAAATAAAAGACCGTCAACCCTTATACAAATGGCTGGAAATTGAATCCAGTTGTGGGTGCGGTCTACAGTCCGGAATTCTATGCAGGCACGGTCCTGTTGTGCCAGGCCAACCAGGAGGGATCTTCCATGTACAGTGCCCCCAGTTCACTTGTATATACTTCTGCAATGCCAGGCTTCCCGTATCCAGCAGCCACCGCCGCGGCCGCCTACCGAGGGCGCACCTGCGAGGCCGCGGCCGCACCGTGTACAACACCTTCAGGGCCGCAGCGCCCCCGCCCCGATCCCGGCCTATGGCGGTGTTGTTTACCAGGATGGATTTATGGTGCAGACATTTATGGTGGTTATGCTGCATACCGCTACGCCCAGCCTACCCCTGCCACGGCCGCTGCCTACAGTGACAGAAATCAGTTCGTCTTCGTTGCAGCAGATGAAATTTCTTGTAACACCTCTGCAGTTACGGACGAGTTTATGCTGCCGACCCCTACCACCACGCACTTGCTCCAGCCCCACCTACGGCGTTGGTGCCATGAATGCTTTGCACCTTTGACTGATGCCAAGACTAGGAGCCATGCTGATGATGTGGGTCTCGTTCTTTCTTCATTGCAGGCTAGTATATACCGAGGGGGATACAACCGTTTTGCTCCATACTAAATGACAAACCATAAAAACCTTCCAATGTGGGGAGAAAGGAAGCTTTCCGAGGCCTGAGTATTGCAATACATGCAGTAGTACATCATTTTAGCAAC + HKKK3KKKK'KIJKKKFKKAJBK9KIKJKEKBKCB:KK*KKKKAKJKK7GKKAKFKKKGKKKJKHI)JKJK>KKK*KK2JKKJKKKKGJJK&6:K:IKKGKKJKKAKEKKJKKK(KKJKJKKGEIHHKKKKKKK=KKKKKKKKKKK+KKK4KHJJJK;KKKKKAKK0KKK9JK?KKJKIKK)-K0KKJKKKKAK?JKKIKKIKKKKJKKKIKJKKKEKJKKKKJJKIKKJKKK$JKIKKBIKJGKK*KKKKKKK5KKJKK6KK:KKKEKKJDK?K&B6JKHKHKK=KJKJKK4KKIKJKK4JHKBKKKKKKKK7KKIJKBKKKJIJKKK7AKKJKIKIKKKKKKJKKEKKKKKKK4FI,KKKKKJKKKGKKGKKKIKIKKHKKEGKJKKKHHKIJKCG@KKKKK?KIKIJKKHAKK?KKCKK3JK=?JKKKKKIHKKK4KJKGJKKCKIKKKKKKJKKIKKK)EKFHKKJ;KAKKKJKHJK9JKKK)KKKKKIKHKKGKKIK/KIIK9CKKKFCJKJKKEK>J=HK>KKK;KDKK7KKKKIKKKJK$@J&KKKKJKKK6EKHKKIEKFKEKKKKKK7DIK2F@KKKKFIKKKKKIKBKBKK5DBKIKJKJKKK/IKIJKGK/K9I0IBKJJK'JIKKBHKK*KK;CKKKKKGKKGK,-KKDFJKFJJK@IEKCKBKJJKK+>FJKKK>EK@KKKIKK>K3KKKKKJI5K7GIKK;HEJK@KFGEKGKKKHK3K)KFKEKKKKIKDKKKKDCKA>KKAKGJKK9GBKFKJKKCK1HKK(KKKKBKEBIKI?KKKKKKKKK-IIK;KKJKCJGEJ5KKJKHAIJ?KJKK2DJJKKKKKKKKK(FKKKKIKIKKKK*KKKKIJIJKJKK8DJF?HE4=IC.KB%JH?KJJ1IKKF4EJ9IFC.KHJF*KK&I/K@F17-KDCBGB76KJ2EKJCBFI*GG?DFKK3KA1FDFKK>KGGFJDKJF@HKJFKKGC:GE5KBGGKKKJ2KJH@KKKGKJ#HIGI+EKCKAIB2I;HD6HG>KH:KKGCKK+KDKKI@K?KKKGJHKD;KKGIKKCK6HKFKK7JFFFIE@JKKJK0JFFKI?KIK@J)G?I>DI@@9G;-EKB5GE:B=KAKJAK*KIKJH:I.K(KCK3KEI7CJBJF@DKECGG=@'JKK3D>JF2CKHIKGD'KJ6FGI<5'GHHJJF@BJI'76K4?85'HB?IGBKCIJGKKHIAKFGJEK>JKJ/JAJ%K0EBD<7I>FKDEG,JHE,IFBGKJIK4KFHK.KJAKCKIK;;GKKJIK@JIEKIJJ;K*K9KIIIHBFBEKHICG:J&FF:<9KHJ@@BGAFDKKIJDFJ8KD>K>KKBKK7KDKGHKKKJJGJ9KGJIJEEEJAFC@'=EHI9:8JK?GBCB?;HDDHFH@KCKEJJKJ4K9JFJGKC?4KC;@IAKJ=JD/H5KDDED@AF9KKJ9K$KKH4K5KIKGEBK+KK@G@FGKHJKFK=?)IKCH>KJEI>KKB3IBKKIFGKKKFFKGKFKACAF:IJ8JFJKDB>DKIKJIEA;DJIADKKAKKDB4KKK;KG(G7ADHCIKI=GK9HJCKGKJFKKJJGJBHIHK8JKKHFJH5KHKKAKK6KKKKHKKDKKKKBJJ6I@H)JKKKJBB76KJAJHJJKKKKCKKKJKKKKKK5JK8KDIJBJJ6KK3KKJ;JIBKHKJJKIJKIEKIK3KKDHC9AKK6K(JJ@FKKKFDGDEKJJ6KKHJEGK93<(KHKI/KKGK@KBKJKJF$B7>>?HJKKKKB0KCKK$JIKJKK6KKJK,KKJC=FKJKAF9KHKKBKKKK4EJGKEC6GKKKKJ=(IFJIIKJI7JC$HIJIEIEKKJKKJIKKG+KKKKHKJIHKKK1KKI7KKF?KG9KKIJGK @rCer/486/25_2135_CCS ATGGGGCAGATGTGCGCAGGCGCCTAGGGGGTGAGGCGCGATGGCAGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCCCTGGCCTGGGCATGCATGTGGAAGTGAAGGACCCCGACGGCAAAGTGGTGCTGTCCCGGCAGTATGGCTCGGAGGGCCGCTTCACGTTCACCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAACTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGTGTGCATCTCGACATCCAGGTTGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGTTACAGCTCCGTGCCCGCCAGTTGCTTGATCAAGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGTATCGTGAAGAGCGCTTCCGACTGACAAGCGAGAGCACCAACCAGAGGGTCCTATGGTGGTCCATTGCTCAGACTGTCATCCTCATCCTCACTGGCATCTGGCAGATGCGTCACCTCAAGAGCTTCTTTGAGGCCAAGAAGCTGGTGTAGTGCCCTCTTTGTATGACCCTTCCTTTTTACCTCATTTATTTGGTACTTTCCCCACACAGTCCTTTATCCACCTGGATTTTTAGGGCAAAAAAATGAAAAAGAATAAGTCACATTGGTTCCATGGCCACAAACCATTCAGATCAGCCACTTGCCAACCCTGGTTCTTAAGGACACAGGACATTAGTCCAATCTTTCAAAATCTGTCTTAGGGCTTATGAGGAATCAGAACCCAGGACTCAGTCCTGCCTCTTTTGCCTCAAGTGATTTTCCTCTGTTTTTCACTAAATAAGCAAATGAAAACTCTCTCCATTACCTTCTGCTCTCTTTGTCCACTTACGCAGTAGGTGACTGGCATGCGCCACAGAGCAGGCCCTGCCTCACTGTCTGCTAGTCAGTTCCGGGTTCACTCAGTGGCTTTGTGAATGTAAATAAGGGCAGGTCTTGGCCCTAGAGGATTGAAATGTTTTTCTATATCTTAGAACTATTTTTGGATAAATTATATATTTTCCTTCCTAGTAGAAGTGTTACTGCCTGTGACTAGCTCCAAACACCCATGCAGTTTCTGCATTCTAGGTTTTTTTAATTTATTTTTTTTGAGTTTTGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCATGATTTCAGCTCACTGGCAACCTCTGCTTCCGGGTTCAAATGATTCTCCTGGCTCAGTCTCCTGAGTAGCTGGGATTACAGGTGCCGCCACCACGCCCAGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGGACTCCTGATCTCAGTTGATCCACCTGCCTCAGCCTCTGCATTCAGTTTATTCACACATTTTTGGTTACTCCCATGGCAGCTCCTAGGATTTCAGTGGTCTGTGGCCAGAAAGCAGGCATTGGGTCTGATCTCAAGGCTGTATCAGAGGGCCAAGCAGAGTTATTTTGGATACCTGCTTTTCATCCCACAGGGCCTCAGAGTCAGAGGTAAGGTAGCAACAGAGCTAGCATGGGTTAATGCACTCTTACCCTCCTTCTCAGCTTTTATTTAAGCTGTGCTAAATGTTTTCTTCGAGGGAACCAGATTTGGTTCTTTGCAGAATTTTCCAGTGAAATAAAACATGTTGTAATAGCTGCGTTTGAGATGAAATAAGATGTTGAGGGCAGACGGGAGGCACCTAAAGGAAAAGAGGAAAGGTGCCTGGACTGCCTATGCAGATGACCTGGAGTGGACTTCACTATGGACTCGTGGTGCTAAAGCTTGGCTTGAACAGGCAGTCTAGGGGACATGGAATACACAGGGTGGTTGCTCAGTCATTTGCAAAGGTCAACCAAATAGAACACACATTTGCAAGATATCATCTGAGAAATTAAGTACCTTCTTAGCCATCTGAATCATAAATTTGAACAAATATACTTCCCTCATGCCCTTCTGTATAAAACTTAATACCATTAGTTCCCCATTCTTGACATTTTATTTCAGTTATTATATATTTATTTGAAATATTTATTAAATTACCTGACCCAC + ?<'?CE@B?FAHGIGGFE>@CB4DCH-HJID?CGHJIDEB;FCGHE.702:CH1AEEC=DFE@CDHFHE?HIHEJ:HH>BJFCFCJFFE?@C8HJ3GF=>;DI>IAHHGJE+HH&AEC>GECEEDIGEEEH(=HE>DAB8BE>GFDCBFEIFEIIHGGB-=9@EHEFAJAIAGHD85CGFJHI:IHGF6BBEIFE2?JF>GE;GHDGEEHIIIG@BFEGGI9HGEFIH:HED+GF?@EG;;EFDFDDF;7C/E@DECBECGEBBHG4FGAFEA@GFFG>HEBGDH-EABB@EHFIIHF=JIIBGIHCJFHEIFGFFBID8>F>EDIIA6HHDI-FBI=7HFIJE>HIBE6IF0DGBFFGHDCIGHIGHDFI1E?F:>DFDICHEIIDEFFHEG;FEHIGD4GI?AIBHHAA<1?EAJI9DIIHFC6GIHGEH>@=GHHGG7AGDDHG?G@GIEI@IH=EECAHH=BBCHCI7IEHDE7FFAIH@G=J;I?BB6EDEI2HDIEBCHI6JAHDAD:@GGIFI3JJ<.5C)DHFHC6C6FA:GB<+*HH.JJJJIDJGF%GHFE@?JJHD6HFDJIFBCGGCJ:A=GEJBAFEC-DG@E?EDIDDGCDHI:HHGBIHHGIII7>;FB5HI?DHIGEF3GDIDGHB?E2B<>?F?<EHGHFGDFE@IHI5JA=D@EC=DBIIHDIEE=FDJJGIHH@IDGHIHB@CCCIHGC@;,G?E7IJAJF7EABBCA9G@HIJIGDCJEGI>HF@C?,?GCFCG1@=H5A9JIFHICHJBCG?FJG?E1>EGG=G>HEFEGHFH6EEII3HHHGFH4%>C9>D>B-E>CDG=IEEB>?.EFC8='GHHFHGFIHFFI=E;HEGDFHID@;EIH'FCDIIGDEJE?F'?+IJGJJ@;HAHFF3JHJHFIEDEC.>AC>DII7G@H9F?EGG?IIDDHDIIIHGJCBGEC?HDAGFD9DCGEBIAABFCI@DGD?HE@>*I/DHHECFIIHGGIH>BIG)?>?BHADECEA9$AAADF>AACA&CGCGGEIF=HIJIF@CC0EFFEIDHCFEA@2IHG4IFEI==>EI>IBAHFHGIIHGKIGI6IE>6IGCC3=A5DHHG9HFHDC2,>CCG2HBHGJCHJDAIDI>BAFAE>>HECAGB%A?FADCGEGGE7BBEBGBBGCEEG;CDF@9D?B/=B*DB8?A;?EACB;B@:7B?D2C>@E>=C1;BCB?FA:DCADC?CEF(=;>>;@CDC4??EB1BB?FEF8?6357BCBDA)>BA=?BFG8FFE;C?@AC8G>A=GD@DDAC;FCBCDEBECFEE=.=A;FFB@?-A<@>CDDFB:;EF:EGDAAFF8B=?;AAC9B1;AD?F3CCCCF?A8DGAGB=4B75DFA@:CGGB>??@7@?BD8=BFCACE6=@F?EFCF<7GF@GB)BAE:BCFFB<=>'?AAADEA)B1>1?CEFB=@A>1@;BCEEC?BBFB:BBACC7C?AC@4<;BFEBBBA@EF@?F;@EC;C8B@GBCCEFCGA<9>4%7<@CD1CD>;DF>:@;FFEDBG@BDC1@C9C5C@B+CFFE@CB5C@E@E/D@?BBGGC=:>@B3=>14<@:BFEC@ACEBFE:AFAE=CED8FC@@=CEF48B'BHGC$DCB::HBFGJCIHFIDF?I@IFFD>FBJCBHIEC@GCDJFDJF7B@E=@FD+H??FHDCB?=AHBF==8DIHHBIFEEE@IIHCDFIIHBJC>GDDEBEE>B<>CEBFJIHE4H86B;@GDGBIGC;GGG?@D5HGGG4IHHFDG8D@;?CA;B?JI=JFAEA6FFC9E?/GEC5?3=?<@4BCB9BED?;?C:BBDD@3FF@FBB,:@8D6ECD>+GEBD?>DA9D?CD*@CBEC?*CF>FA0EGFFBACGBCBC->7?BAGD>31?A?8BA?E?6?B@ACCFBDBAE/A>@;AD:D)CA>@8(9559?B628A7=0BAEFA+F?6GC>E'B4@-'?>FGG=GD9EC;@E?5<9CDFG?DF9?=BG@CD:>=FEAE?FF@;EC26?;>ECGB=@;=:.E?6CA55=;5<0=DGFDFDC6BAFFE4@7BBFABEA,?;CB?:ECCD;D?F@3@C>FADCA=BBEEB@<8D>9:&@67&3=GFEGBA?BCBAF@9&DDAB=C=<(EDD=?G2+@DB&E3C>@D<;EA?A9?;B8FBA?BCAE?95=:=,6>>B<0:<9#9<>6@?@EB9F96B@A0FGGGGD55@B?>-BCF9:A=DFC;EC7EC?9DB.;<@>@A@F@@:DE5EB=:1B+9@C2AAG7BD&@BDAE;CC@FE6@@>FABFAC=@BAEB.AEEC@A@@FCECED>C2:B=%D8BEF::6A?4E?6C??@6;)>?9*=67A@C=>@?6?;(<4A;D;>8C>6D2BC;@E36>,BAAAG8;EB8AEDAF>B>?FC9FE?9D@@DCE?BBBEDFDBE>EECCC:<>BC59=?B=FA==A?>BAFF@:A=@BA@7AB3EFF=,C9<8D=@@AF?4CCEE<:4?FFF0E?F;G>D'E=2=@BA@>?:@>?FFAAEF?B6@AF7:@DEBCE>E;C45?F95DAEF@=4E:=CCFBEGDFDEFA=FFC=CE6BGEGB5BGB.@@B;=D=A=>:B?ABCDGE:CAAF@:8BDBBFD;GDFBB52AE@@@GD@CFC=3BE?1BGEA;D?E>D:EBBEDFAE?8@>F8G7$>CB69G.G7D0GGGC>D1D::FFADDFCDF>A@E+D:?BCC@B&ACEBB+FA$@B07:?*:FF?BGCA?A2EDB9A1FE?FDD4DCDBFEE8GGFEC8CD=D:93A<<=FBCE5CD.CFCC93@B@A6@< @rCer/492/25_2655_CCS ATGGGGATGTTGTGATGGAGAAGCCGCGGCGGAGCCGAACCCCGCAGCCTGAGCCACCTTCGTCATCTGGGCCGGGGCCTCGCCGCGCAGGAGCTGCCAAGGCCATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACGGAGGCCCCACACTGAGCCTACCCCTGCCTCTGCACGCTGCCCATAACCAGCTACTCAACGCCAAGCTGCAGGCCACAGCTGTGGGACCCAAGGACCTGCGTAGCGCCATGGGGGAGGGTGGTGGGCCTGAACCAGGCCCTGCCAATGCCAAGTGGCTAAAAGAGGGCCAGAACCAACTCCGGCGGGCCGCCACGGCCCACCGTGACCAGAACCGCAATGTGACCTTGACCTTGGCGGAGGAGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCCAAAGGCCTGATACACCTGTACTCTGAGCTGGAGCTCTCAGCCCACAACGCGGCCAACCGAGGCCTACGAGGACCTGGCCTGATCATCAGCACTCAAGAGCAGGGGCCAGATGAGGGAGAGGAGAAGGCGGCAGGGGAGGCTGAGGAGGAGGAGGAGGAGGATGATGATGAAGAGGAGGAGGAGGACTTATCTTCTCCCCCAGGGCTGCCTGAGACCCTGGAGAGTGTGGAGGCCCCTCCCAGGCCCCAAGCCCTTACAGATGGCCCCCGGAACACAGCAAGAGTGCCAGCCTGCTGTTTGGCATGCGGAACAGTGCAGCCAGTGACGAGGACTCAAGCTGGGCTACCTTATCCCAGGGCAGCCCCTCCTATGGCTCCCCAGAGGACACAGATTCCTTCTGGAACCCTAACGCCTTCGAGACGGATTCCGACCTGCCGGCTGGATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCAACAGGGACCACCCAGTGGGAACCCCCCGGCCGGGCCTCCCCTCACAAGGGAGCAGCCCCCAAGAGGAGTCCCAGCTCACCTGGACAGGTTTTGCTCACGGAGAAGGCTTTGAGGATGGAGAGTTTTGGAAGGATGAACCAGTGATGAGGCCCCAATGGAGCTGGGACTGAAGGAACCTGAGGAGGGGACATTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCATTGCCCCAAGAGGAGGAGAAGCTACCCCCACGGAATACCAACCCAGGATAAAGTGTTTCGCCGTGCGATCCCTAGGCTGGGTAGAGATGACCGAGGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTGCATCCGTCAGCTCTCTTACCACAAAAACAACCTGCATGACCCCATGTCTGGGGGCTGGGGGGAAGGAAAGGATCTGCTACTACAGCTGGAGGACGAGACGCTAAAGCTAGTGGAGCCACAGAGCCAGGCACTGCTGCACGCCCAACCCATCATCAGCATCCGTGTGTGGGGCGTTGGGCGGGACAGTGGAAGGGACTTTGCCTACGTAGCTCGTGATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCCGCCAAGAACATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCCGAACGGCGTAATGCCCGCTGCTTGGTGAATGGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCCTTTCCAAGTGGAATTCCCAGCGCCTAAGAATGAGTTGGTCCAGAAGTTCCAAGTCTATTACCTGGGGAATGTACCTGTTGCTAAACCTGTTGGGGTAGATGTGATTAATGGGGCCCTCGAGTCAGTCCTGTCCTCCAGCAGCCGTGAGCAGTGGACCCCAAGTCATGTCAGTGTGGCTCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGGTGCGTTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCCACACATTTGCATTCATCATGGCTGCCGGCCCAGCCTCCTTCTGCTGCCACATGTTTTGGTGCGAGCCCAATGCTGCTAGCCTCTCAGAGGCTGTGCAGGCTGCGTGCATGCTTCGCTACCAGAAGTGTCTGGATGCCCGTTCCCAGGCCTCCACTTCCTGCCTCCCAGCACCCCTGCTGAGTCCGTGGCACGGCGTGTAGGGTGGACTGTCCGCAGGGGTGTTCAGTCGCTGTGGGGCTCCCTGAAGCCCAAACGGCTGGGGACCCATACCCCATGAAGAAGCCTCTGCCTTCCCTCCACCTGCTTGTGTCGGGCCCCAGGGAACTACAGGGTGTGGGTCAGGTAGGGGTCTAGAGGCTATTCCTAGGCCTTAGGCCTCCCAAAATATGCCCCTCCCCAGTAGCTAGGGTTCCCTGCCTAGGAGCTGGGGAGGGAGAGATCTAATCCCTTCAAGGAAGTCATAACACTGGTGTGGTAACAAGAGGAGCAGGAAGCAAGGCCAGCCCTGGCTCTCCATCCCCATGTGTTTCAGGTGGAACAGGAGGAACTGGCCCAGGCCAGGCCTCATACTCCTGGGACCCAGCAGGGGCAGGAGGAAGGGACTGGTCCAGGCATGGGTCCCTTCCCTTTGCCCGTGGGCACCTCTACTGTATTGATATCACTAATAAAGTCTGTCTGCACT 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-+&+$'-/,02-1111121...1/2//,/,021/$3')0/21533/,06*20(06226(241166664)1,*)+.%5/615645666656136511-44653/2%351446262451505-1-/3)146566456161*2.33346/53+)265/0785;3:5:2955/877/737477;857:080::9-8850/5887%64:::0139/4,587/2897108:79;4:5929559:95:2(674:/1,255-64/78523949'8242157769;:267268207177/7/54581:8949.65654/74518987984889314::9088:4326517:598*3.655032+144/3614'4383628145:85&-8-48737385::5955:,)5790:8;86;:8698:54'889:5073:;89:1:76&1.3:75-3939=/0:=>:==9=<>>;=51238;379>:<1=<9:6=<=84=3<8;3725297;<9>>:;<3;886;89.;3<9=<<2;7?<==0=289=:0?>95=:;9:=>->;9<=6>936=1<<2==>9>;<5997<97687<75<758:09::/82466;5/743979:>:=?>:;<*7/16;59:198;25;>9=1>>:=;1=:>9:<4;:::978468:81399:/=487'9;=4><9?'=<>84>;9/7876:<:79:?89=>9379?76;>;<99/:4=:>;9>56999855<<7<-=<;493977872669==?<826;:;79=9;:8<9;1<775::9<19>;2>>;>8>8?>>=?69/:;6-76529/9769=>?;=)9:29287>;969:69<3><=>?:>>:9:?71>;7;0337:3<149=8996-46;888981213%6+;5753975;;7>7773.47-52=>???;?993;=989'1/7::857>9==>:9=>5???=9:;38<9>1.221661957:88567:060>>>=865;4<7;=9?>>=9>=?69694=?;583?:96<>1<#;367:<:<6*<*6776771368::3975:6::?;:9=9<<::3780<840:;:;9=7=8;+>>><31=<9=>;?<88:-9;98598:;9?119:7%++5:==<>9/7;;>82*.,00475837895>/=8<>3%67989:366(488=9:679838:/6569,8377<=74774.46*4;9:9=5;5226:376?6>:7=2:;:2=:::=9915<<>:5.557;298>>>7=7646772::=7>56=53';=<8389=4:78;680:;6==6872/5<=<<;93<7;;<2><=6<=7>7=?=>9=8:=2<659:6;9999>972/767/2:?4:9869783<<7598=<>:9:0<79>5795:88<:1>;393:=;=;;9=8<=98:?7;3:862;:89;878;>99<;78>=0?;??>>.9;899<3;?>9<9=:>3<>:=?:>86=/889;<566244;89:;=<;<8=4??:>?>9<>>4<;:4<>=:?>?>8=<531;8>2;=4;>=>99=>=><>:8:>7<9<9:;=8=:63=4;=99>:=;;<9?17439;>3<;:<5978;==5=<>>>>8=>>7>><=9=:==.<=99==>=?<9<.8>?>??8=.;=<9<4;0:.8578671=:>?=9=6>?>0=:?<7>8:9?=>?8><=895697:0;?>5=;?9<>?=>=?;<5:66914316.4#/(/5301762675886/750:<0*745=;0:=>9<4;::=?>?6;::/7:=7=;:9;<;1=<8>11:>96479<:96458>;78998<7;9:964(7.4897>09?>9>67779:>;6:<>361?>993:792>4:2:7677639=889;&46,;=>>:=8<*4:;?7;;5-4232698199=5/8/-55/67964$4496+-3-28886:4;'479:19407.6/-7683/5/4127+466549684,3*97452-966553-37:6695529;89::6102::86+8696)126323756:/:6866/::658699:74;;7/6677154/83.1/7590992159&354:44&,().:98240/222'''&2/7;9635684563&8659762620/365688057106542463.39:44198598;55:;/988::5709868:;;9::.:::6561951:9'13998467;09:::9::;863/648:::0;4*7342499-32488/09:01219:564-4358;;866146656.12*8)70-.608195083:2.14%0-01/42)5554*/5416662501./,460621..651-6113046666.524669997:166.55/898;.65;865886:7::665682/393579;867:.5458:-543236;8;8:4::89;8*174290/:9915+.35897779:7:7974:;96;7957442:95%54619:,694076,,(63-65,'/45395,7953)(51.115,3400+.0/4/.*4655.46327928-63-660%&136)5/2-56167883341*754312-(566:7+879:596::355668 @rCer/493/507_50_CCS ATGGGCAATATTTTTTTCTTCCTTTGGGTACATAAAGCAATGACACATTTTACAATCAATGGTCTTGGTTTTGATAAAATACAGTTATTATTCCCAGATATTCCCTAATATTTACAAGTGAGGAAACTGAGGCACAAAAGACAGTTTAATTAACTTGCTGAAATTTACACATAAGAGCCAAGATCAGGGCCGGGCGTAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAGGAGTTCGAGACCAGCCTGGCCAACAAAGTGAAACCTTATCTCTACTAAAAGTACAAAAATTAGCCAGGCTGGTGGCACATGCCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGGGGTTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAATAACATC + KKKK=KKKKKKKKKKK6KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKIKKKKKKKKK;KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKHKKJKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK8KKKKKKKKKK7KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK*KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKJKKKKKKK @rCer/494/1497_54_CCS ATGGGGACTGCAACGCGGAGGAGCAGGATGGAGATCCCGGTGCCTGTGCAGCCGTCTTGGCTGCGCCGTGCCTCGGCCCCGTTGCCCGGACTTTCGGCGCCCGGACGCCTCTTTGACCAGCGCTTCGGCGAGGGGCTGCTGGAGGCCGAGCTGGCTGCGCTCTGCCCCACCACCCTCGCCCCCTACTACCTGCGCGCACCCAGCGTGGCGCTGCCCGTCGCCCAGGTGCCGACAGACCCCGGCACTTCTCGGTGCTGCTGGACGTGAAGCACTTCTCGCCGGAGGAATTGCTGTCAAGGTGGTGGGCGAACACGTGGAGGTGCACGCGCGCCACGAGGAACGCCCGGATGAGCACGGATTCGTCGCGCGCGAGTTCCACCGCCGCTACCGCCTGCCGCCTGGCGTGGATCCGGCTGCGGTGACGTCTGCGCTGTCCCCGAGGGCGTCCTGTCCATCCAGCCGCACCAGCGTCGACCCAGGCCCCACCGCCAGCCGCAGCCAAGTAGGGGGCTGGGCCGCGCCCGCACCCGGGAGCGTCCTCAGGCTCCCTCTATTGAAGCCGATCGACTCCGCCCAGCCAGATGTCCCGAGCGCGCCAAGAACTGTCCTCTCACCCACTCCTGGATTCTGCCCTGACCTCCACCCTGGACACTGCCTTGATAACTAGACCTTACACTGACACCCTCGCTCTCACACCTCTCCAGCTTTCGGACCCCACACCGACACCTCGCCGGCTTCCAGACCCTACCAGCACTACCCTAACCTCAGCCAACAGTCTCAGCCCCACCGACCCACTTTCTTGGCATATAGCCCACTTAAGACCCCTTCTCTACTTCCTTCTGAGTCCTCTACGAAGATATCTGTGGTACTACATTTCCATCCCTTCCCTATTTTGACACCAATTATGTGTAGACAGCCCTCCCCAACCCAGGCCTGTCAGCACAATCCCCCCACCTCCAAATGTCCTGGACTGCACAGACTTCCCACTCCAGACCATCCAGGCCTGGTTCCAAGACCTGATCCTCCCCTACGACCAGACAGTCCACAACTGCCCGCTCCAGCCCATTTTCTGCTGTGAAACCCAGCCAGCCACACAGACTCTGGAACCCTCTTCTGACCACCCTAATTCTTGGACACCTATCCAGCCAACCAGAACACCCAACCCCAAACTGTACAGACTCTCCCACCCAACCTCCCCAGACTCTGCACGAATGTCCTAGGCCCCCTCCCTAACTCTAACCAGACCCCGTCCCCCTAAGTCCCTTTGTCTTGACCCCCAAGTCTTCTTCAACCAGATAATCCTCGGCAACCCACCTCTCACCCCCTCCTCTCTTCTCCTTCAAGACCAGCTGAGCACCGGCTCTGATTCCCTACAGCCTTTCTCCCTGCCACCACTCCCTACTCTTCCCAGGCTCACTCTCCCAATAAATGTGCTAGAGCTCT + @866;)7079/<69??;831/4<7/13>CF;BFA7;<.@751;2?B50DADB:?>;>8:A=4+==?)@:A46B6AEE;E?B?CEDE88:9;13A82;9?9>>A>-?:<;84><=A9;@8A;C935+=2;?-<*47*>:=7>A;A9B:>CCBE;;?569(4<,.7;/BC@>CE?'24;3:@3167;:CC>FE0BA@=>@57=>>A?2FA>F@8B?=E3B<:>>95>;0B@3?98<1<>>A6<6:0681<><)=8&46-CF@E<9785?9A?6)11?EFE8B>?):8<<161%5<3C@D8DF,>E;E;>(4?7587?@?4><&;=268*+7(3?BC:79A;:?;>EC=1:9,;==B<5:;6?=<';;0=:@EE?3??@@=7.-10:?-<97=?7392@;DB59A@>G8;A<8?C31;;A:3D944=7=B>?57@>2=<;B>B@>49>.;?B;7;C3;854.-..43535$18908682883@(:;7;722666;*:9/3>8:7.5<9',%&4(,077?99'5/344+8,,165&//..102,%1641-*%2)34983,*+5&&1,$6/00441+-(.'),(1404*6052()#&3*.,(+461/.1,,03-($1.2-',.2021),'/22414.00-../34(1-3.-'%#+(*'%&--1/.0/31.(&021#,+.0#*),3.+*0-,#&-/5042/**/%2/-/0$)1()'-3+16)/..0/,,%(+.2)$)$%,14-)()63004051+/)+1//*,$%%,.4240),4,*.)(%&%-.&0,&...&,3++,+.*3.001$+/-+)$/'-*/)01'0+-3-(0-)/&*1(1..2/0+.,)((%*,10-02/.,53-551*024.4003-).+&*((,'40*-'),14.((+%*/-'2,0(0)+-35*3+.)/'/2'.3+302*3.2,*(.+'0).(.&1.-.35,-&,55656504*1/,0.1((01*'.0($1/3&/4112440.151+.0.3&/14,22*12.1166011*54/60.)+*-*'.'+))*+/3..+)0-%-'41*,+&$)-**0*'($'/,2.03+--()%1,./,(.&%+1433.56*+,-#--/42-44-1/651&/*23-(62,-56,44-24(-+/0&014-.3''*-+0*#'*(+,##0(,.),1-&/0+).0+,--.0*00-+%+0-/1/,,, @rCer/497/25_1523_CCS ATGGGGGGAGGATGCAGACGCCGCGGCCGGCGATGAGGATGGAGGCCGGGGAGGGAGCGCCGCCGGCGGGGGCGGGCGGCCGCGCCGCAGGCGGCTGGGGCAAGTGGGTGCGGCTCAACGTCGGGGGCACGGTGTTCCCTGACCACCCGGCAGACGTTGTGCCGCGAGCAGAAGTCCTTCCTCAGCCGCCTGTGCCAGGGGGGAAGAGCTGCAGTCGGACCGGGATGAGACCGGGGCCTACCTCATTGACCGTGACCCCACCTACTTCGGGCCCATCCTGAACTTCCTCCGGCATGGCAAGCTGGTGCTGGACAAGGACATGGCTGAGGAGGGGGTCCTGGAGGAAGCCGAGTTCTACAACATCGGCCCACTGATCCGCATCATCAAAGACCGGATGGAAGAGAAGGACTACACGGTGACCCAGGTCCCGCCTAAGCACGTGTACCGCGTGCTACAGTGCCAGGAGGAGGAGCTCACGCAGATGGTCTCCACCATGTCTGACGGCTGGCGCTTTGAGCAGCTGGTGAACATCGGCTCCTCCTACAACTACGGCAGCGAGGACCAGGCAGAGTTCCTGTGTGTGGTGTCCAAGGAGCTCCACAGCTCCCCGAATGGGCTGAGCTCAGAGTCCAGCCGCAAAACCAAGCTGTTACAAGCCAGAGGCACCCGGATGTGAGGCCCCAGATCACCTCCAGGGACTTGGGGTTCCCATCTGAAATCCTTTATTTTTGTACCATGGGTGGGCCCCGGGCCTGAGAAGGAAGAAGCTCCTCTGTCTGCACCTGTGGGGCTGTGACTCACCCCTGCCTCCAGGGCCGGGGCGGGGCGGGGGCCCCCGGGACCTCTCAAGGCCCAAGGTGGGCCCCAGGATCTCTGGGCAGAGCCGACTGCTCATGGCGGGACGTGTGGCAATGTCTGGCTGTGTGTCTCCAGCCCCGCGTCCCCTTTCCCGGGCTCCCCTGCTGCATGGCGGATGCACTCCTTCCTGGCCCAGTCACATCGCCTCCTTGAGCCTTAGTCCAGGGGGTAAACTCCTCCCACCCCACCTACCTCACAGGGTTGTTGTGAGGGTGCACAGAGGAGCAAGGTCCCTGAAGGCCCTCGGGCAGTATATAGGGGGCCGCCCACCTTCAGCTGCCCTGGGATGGGAAGGACCCAGCCCAACCCCTGGGCGTAACACTGTGTTTGCAAATGGAGATTCAGGTATTGGGGATGCAGGTTGTGGGGAGCTGGCCTGTCAGAGTAGGGGTAGGTGGCTTGGCCTTTACCTTGGTGATCCCATCCCCAGCCATTTGCATTGCTGGCCCAGCGCCTGGCCTGGGGGGCGGGGAGAGGCAGCAGAAGGGGCTGGGCAGGGGCGGTGGAGGACTCAGGAACTGCCCGGGGAGAGTGGGTGTGGCGGCTGAGCCAGCGGCCGTCCTGTGTTTGAATTCCTGGAATGGGTCCTTGCTTCTCGGCTATGTCGGACCCCACCGTGTAATAAAACCCGAAGGAACAG + 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@rCer/498/25_1767_CCS ATGGATGACCCAGCTTTTAGTGCTGGCTAGGTCTCTGGCCTGCTGCAGCTTCCATTTGCTCCTTATCTACCCTCTAGGCATCCAGTCTGGCTTAACCAGATTTCATGGCCTCATTTTGTCCTCTGCTACCGTGATTTCTACTCCTGAGGAGAAGCATAACTATCTTCTAGAGGGAAACATTTTCGCTTTGGTTATCAACCTTGGTTCTTTTGGGATATTGGAAATTACCCATTGAATGGACCCAGACTTACGGTGGAAGCTCCAGCACAATTAATGCTGAACGGGTTTGTTCTTTTTCTTCTGGCTTATAGTTGCATTATCCATTCTCATTACAGATGAAGAACTTCCAAATCTGTTTGTTACTTCTACCTCCCCCAGCCTGTTATTTTCAGGGTCACACTATGGAAGAACACTGTGGTGAAGGAAACACTCCGAATTCCTTGGGCAGGCATAGTCACTCATGTCTTTATTTCTGTCATGTTCATTTTGCAGTCCTGACACTGCTCTGTTGCTAGAGCTGCAACTATGTAGGTAGAAGTACTGTTGGCTTCGGGATACACACTGGCAACTCTATAGTACACTCTTATTTGATGTAACATAAGTATGTTTTTAAGAATTCATGTTATCCAAAATTATAAAAGCAGTTCTTTGAATGAGTGAAAGAAAGAGGGTTAAGGTTAGCTCCATACAAAGTCATATATAAGCAATGCAGCTTTTTAATTTAGCTTTTATTTAAGAGCAATGACCCTTTACCACTATCACTGGCAGTATACTAGCCTGCACCTTGTATTACTCTATTCCTCATCGTTTTGAAATATGTGCAACAACACTCAAAAGAGCTGTGCTACAAGAAACAATTTTCTTTCTGTAATGCCTTCCCTTTAGGATCACTAGAAGTCTGTACAATGCAGTTCAGATTCCCAAATTAATTGTCTTTCCTATTAGTGTTATCAAAACTCATAGCAGATTCCTGTATGTGCATGTATGTTATGAGTTGGATAAACGTTGGTGGACTTCATTTGGAGTGAATCAGAACGGGATTCCTGTGAGAAGCCAACATCCCTCTAAACAAACTTTTGGAGCATGACATGGCTTGGGTGTTTTCCCCCTCCAAATCTCATGTTGAAATGTGACCCCCAGTGTTGGAGGTGGGCCTAGTGGGAGTGTTTGGATCATGGGGTGGATCCTTGTGAATGTCTTGGTGCTATGCTTGTGGTAATGAATGAGTTCTCACTCTGAGTTCACGTGAGATATGGTTTCAAAGAACCTGGGGCCGGCTGTGGTGGCTTATGCCTGTAGTCTCAGCACTTTTGGAGGCCAAGAGTGGCGGATTACGAGGTCGGAGATGGAGACCATCCTGGCCAACATCTTGAAACCCCGTCTCTACTAAAATACAAAAATTTGCGGGTGTGGTGGCATGCATCTGTAGTCCCAGCTACTCAGGAGGCGGAGGCAGGAGAATTGCTTGAGCCGGGAGGCTGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAAACAAACAAAAAACCTGGCACCTCCTTCCTCTCTCTCTCTCTCTCTCGTTCTCTCACCATGTAACATGCTGGCTCCTCTCCTCCTGCATGATTGTAAACTTCCTGAGGCCCTCACCAGAAACAGATACCAGCATTATACTCCTTGTACAGTCTACAGAACCATCAGCCAAAATAAACCTCTTTTATTC 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@rCer/501/2038_57_CCS ATGGGGCTTTGGAGCGGACCTCGAGGCTCTGCGGCACACAGTCGGACCCAGTCGCCCAGGCACCGCCCGCGCCCCGCGGCCGCGACCGTCTCCTGCGCCGCCCAGAGGAGGGAGTTCCGAGCATCCCCCGCGGCGGCCACTCCTCGGGGCCAGGAGCGGGGAAGCGAAGTGCGAGAGACCCCGGACCCCAGCGCAGCCTCTTCCCGCCGCCCTAACCACCATGACCCACTTCAACAAGGCCCTTCCTACGGGCTCTCGGCCGAGGTCAAGAACAAGATTGCTTCCAAGTATGATCATCAAGCAGAAGAAGATCTTCGCAATTGGATAGAAGAGGTGACAGGCATGAGCATTGGCACCAACTTCCAGCTGGGCTTAAAGGATGGCATCATCCTCTGCGAACTTATAAACAAGCTACAGCCAGGCTCGGTGAAGAAGGTCAACGAGTCCTCACTGAACTGGCCTCAGTTGGAGAATATTGGCAACTTTATTAAAGCTATTCAGGCTTATGGTATGAAGCCACATGACATATTCGAAGCAAATGATCTTTTTGAGAATGGAAACATGACCCAGGTTCAGACTACTCTGGTGGCTCTAGCAGGTCTGGCTAAAACAAAAGGATTCCATACAACCATTGACATTGGAGTTAAGTATGCAGAAAAACAAACAAGACGTTTTGATGAAGGAAAATTAAAAGCTGGCCAAAGTGTAATTGGTCTGCAGATGGGAACCAACAAATGTGCCAGCCAGGCAGGTATGACAGCTTATGGGACTAGGAGGCACCTTTATGACCCCAAAATGCAAACTGACAAACCTTTTGACCAGACCACAATTAGTCTGCAGATGGGCACCAATAAAGGAGCCAGCCAGGCAGGGATGTTAGCACCAGGTACCAGAAGAGACATCTATGATCAGAAGCTAACATTACAGCCGGTGGACAACTCGACAATTTCCCTACAGATGGGTACCAACAAAGTTGCTTCCCAGAAAGGAATGAGTGTGTATGGGCTTGGGCGGCAAGTATATGATCCAAATACTGTGCTGCTCCTACAGAACCTGTCATTCACAACGGAAGCCAAGGAACAGGAACAAATGGTTCGGAAATCAGTGATAGTGATTATCAGGCAGAATACCCCGATGAGTATCATGGCGAGTACCAGGATGACTACCCAGAGATTACCAATATAGCGACCAAGGCATTGATTATTAGATCCACACAGAAGGAGCGCAGTATTTAGTCCATTGTTTTTATTCAGTGAGAACCAAGCTAGCCTTGAGTAATTTTTATCTTGTCTTCCTAAAACACTATTAAGCTTATTGTACTTTTAAGAAAAATTGCCTTACATACATTCCTTTTTCCTTTTTCTGCCTCTTCCCTCAATAGTTGCCTTTTAGTGCTGTAATAGTTAAATCCTACAGCATAATCAGTAACTCGCATATGAAGTAAAAAGGAATACTGTGAAAGGGGAGTACTCTTGTACAGCCAGTTCTTGTATGCAAAGATCTATGCATTTTTACAATCTTATATTAAACTGGTATTTTCAAACAATAGAAACTATTTTTTTTTTTTTTTTTTTACAGTTTAGTGTATCTGGTTTCTACATGGAAGACTAAACTCATGCTTATTGCTAAATGTGGTCTTTGCCAACTAAATTTAAGATGCAGCATTTTAGAAATTTACATATCAATGTTTCTACAGTATTGTTTGCTAATTTTTAAATAAAGTCATGATCAGTGTGCATTTGTGATTATATGTGTACTCATTCTCTTACCTAGCGGACAAGATCTTTTCAGAGTGGTGTTTCTAAAGGAGCATGTACAAAAGTGGCCTGTGGACATTTAGGCCTGGGTGATGCATTTGCTCTTCCTGTTTGTGCCAATGTATCAATGTAGAGTTGCTCTGTTTTCTTCAACTGTATTTATTGCTGCATTTCTCAGCATAAACTTATCCCATTGTATTTTTTATAAATAAATATTTTGTTTT 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rCer/503/25_2375_CCS ATGGGGAGCTGGGCCGGCGGAGCAGAGGTGCAGAAGCAACTGCGTCCAAGCTGTCTGGCAGCTTCAGGTGGACCCAGAAGACGTTCCCAACTCAGGGAGACTCAGCGATCACTCACTTGCTGTACAGAATGATATTCCTCACGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGTCACTGGGGTGCCTGGATGCCCTCCTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATCCCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCCGTGGTGCATGGCGTCTGGTACTTCAATAGCCCCTACCCAAGAACTACCCTCCGGTGGTCTTCAAGTCGCGCACCCAAGTGTACACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGCAACTGCACCCTCCTGCTCAGCAACGTCAGCCCGAGCTGGGCGGGAAGTACTATTTCCGTGGGGACCTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGCGTCCTGGACATCATCAACACCCCCACATCGTAGTGCCCCCAGAGGTGGTGGCAGGCACGGAAGTGGAGGTCAGCTGCATGGTGCCAGACAACTGCCCAGAGCTGCGTCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTGGGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCGCTGCTGCACTTCGTGCCCACGAGGGAGGCCAACGGCCACCGGCTGGGCTGCCAGGCCTCCTTCCCAACACCACCCTGCAGTTCGAAGGCTACGCCAGCCTGGACGTCAAGTACCCCCCGGTGATTGTGGAGATGAACTCCTCGGTGGAAGCCATCGAGGGCTCCCACGTGAGCCTGCTCTGTGGGGCTGACAGCAACCCGCCGCCGCTGCTGACCTGGATGCGGGACGGGACGGTGCTCCGGGAGGCCGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAGGACGGCGTCTACGCCTGCCTGGCCGAGAATGCCTACGGCCAGGACAACCGCACCGTGGGGCTCAGTGTCATGTATGCACCCTGGAAGCCGACGGTGAACGGGACCATGGTGGCCGTAGAGGGGAGACGGTCTCTATCTTGTGCTCTACGCAGAGCAACCCGGACCCTATTCTCACCATCTTCAAGGAGAAGCAGATCCTGGCTACAGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCGGCCGTGTCGCCCGAGGATGATGGAGAGTACTGGTGCGTGGCTGAGAACCAGTATGGCCAGAGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCTCCTGTGCTCCTCCTGGAGTCCCACTGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCATCCGTGGCCTTTGAGCTGCCGTCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTCGTGTACTCCGAGCGCAGCGGCCTGGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCCCAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAGCTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCTGTGGTCGCCTTTGCCATCCTGATTGCCATCGTCTGCTACATTACCCAGACACGCAGGAAAAGAACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAGCCCTGCCGTCCTGTTCAGCAGTGACTTCCGCATCTCGGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAGAGGAGGCTGCTGGGCCTTCGGGGAGAACCCCCAGAGCTGGACCTGAGCTATTCTCACTCGGACCTGGGGAAACGGCCCACCAAGGACAGCTACACACTGACGGAGGAGCTAGCTGAGTATGCTGAAATCCGGGTCAAGTGAAGGAGCTGGGGGCAGCCCATGTGGCTGACCCCCCTCAGGACCCTCGCTGGCCCCCACTGGCTGCGGGCTCCCTTCCTCCCAAAAGTAGCGGGGGCTGGGGCAGGAGGGGAATGAGGCAGGTGACAGTGAGGTCCTGGGGACCTGACCTCCCCCTCCTTCCCAGCTGCCCCTCCCTGCCAACACCCCCACGCCCTCATTACGGCTCCTCTCCAACCACCTTTACCCTCATCTGTCCGGAGAGGAGCTCTGTCTGTCCGTGTTATTTATTGCTACTTCCTGCCTGGTCTCCTGCCCCGACACCTGGCCCCAGGGCCTGTACAAAAGGGACATGAAATAAATGCCCCGAAG 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@rCer/504/1663_50_CCS ACATTACAACGCAGGTACTGGGGCTTGAGGACAGACCACGACTGACTGCCGAGTGCTGGTCTGAGCGCAGAGAGGAGCCGCGGCGGGCGACGGCGCGGGGGCGCGGGGGCGCCGAATCGGGCCCCAAGCGCGGGCCCGCGGGGGCTCCTCGCCAGCAGCTCGTGGCCAAGTCGCACAGCTTCTTCTCGCTGCTGAAGAAGAACGGCGCTCGGAAACGCAAGGGGGACCCCGACGCGAGCAAGGCCGGCGGCAAACAAACGGGGCTGCGGGGCTGTCAGCGCATGCGTGGCACCGGAAAGAAGCGCAAGCGAGGCGCGGAGGGGCGCGCGGCGGGGCGGCCTGATCTGCCGGCTGCTCACCGCCAGCTGGAGTGCGTCAAAGGAGGACGCCCAGAGCGCGCGACCGAGGAGCGCCAGGAGCCCGCGACCAGCAGCTGTGGAGATTTATGCAGACCAGAGAAGAGGCAGGTCCCGCTGTGACAAGCATGCCCCCGGCAGGCAAGCCGGCTCTTTACAAGAACCGGCGTGGGCTCCAGGGAGCGGGGAAAGATGGCCACCGACGAGGTGGACGACACTCCTGCAGGTTCTGGACATGCGTCCCAGACCGAGAGGCACCGGGCCCAGGAGGCGCGGCTAAGTGGCAGCTGCGCTGGAAGCAAGTGGCGCCGAAACCCCAAAGACACCAGGTGTGGGAGCGCCAAGGACGCGTCCCGTCAAGCGCGGAGGTCAACCGGATTCCATCGACCCATCCGAAGAGGACCAAGCCCCGAAAGAGCAGCAGGAAGCGTCCCCAACAGCGACGAGGCTACTGGGACTCCACACGCAGCCAGAGAGACAGCGCACAGCGGGAAAAGGCGGGCATCCCCCGATAGCTACGTGGGACGCGCTCTACATCTCTATGCACCGGACGGAATCCAGAACCTTCCTGGGGGAAGGACAACGAGAGACTCCTGCCTGTCCGTTAAGCCGTATTCCAGCACATCACTTGTCCGCGCGAACCCAGGCAGCTTGTTGAAGGACTTAAGTCCCTATTAGCATCAAGCATTGACAACCTTCATCTAGCCATCCGTGGTGCACCAGCAACCTCCAGGAGTGAGATGCCAGAACAAAATCCGGTTCAAAGTGCTGTCCGCAGAGTCAGAACGGGCTTGGCTGGGACACCATCAGGGCACGGCTTCCACGACAGTGCCAAAGTTGTGAGGTCTTCCAGCAAGTGATGGCCACATGCAAGAATACAATTTCCTGGAAACACTGCAGTTAGTTTGCTTTTCCTAAAGAAAGTCTTTCAGGACACACCGTCCGCTGCCAGAGCATGACCGAGAGTGTCTGTGCCTGAAGGACAGGATAACACGGAAAGAGGGATCTACACTTGGGTTCTCCTCTAAGATAAGTCCTGAGAGTTATTTTCAAGCACTTTTTCTTTTTACCTTTAATTTTCTTCTTTTTTCTTTAATATAGTGAACTTGGAAGTCACCTTACTTGCTTTGCAGAACAGGATAGCCAAACCTAATAAGAGCATGCTGATATTGGATAGCCAGTGTCGAGCCTGAAGGAACCACTGAGAACAGAGGAGATCTCTTCAACGATTTCCTTCCTTCTTTTCCTCTTTCCTTC 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@rCer/505/24_1884_CCS ATGGGGAGCGAAAAGCCGCCGGTGTTTCTCCACCTGGCTCTCCTCTATCTCCGGGCAGGCTCACCCGAGATCCCCCCCACACCGAACCCCCTCTGCACGCTCGGCCCAGCGCTGTTGCCCCGGGAGCGGACGTTTCTGTAGCTATTTGAGCACACCTTGACGTCGGCGGAGGGAGCTGGACAGGGCCAGCAGCGAAGGAGGCAGGCCCCGCGCGGGGAATCTCGGAAGCCCTGCGGTGCATCATGAAGTTCCAGTACAAGGAGGACCATCCCTTTGAGTATCGGAAAAAGGAAGGAGAAAAGATCCCGGAAGAAATATCCGGACAGGGTCCCCGTGATTGTAGAGAAGGCTCCAAAAGCCAGGGTGCCTGATCTGGACAAGAGGAAGTACCTAGTGCCCTCTGACCTTACCGTTGGCCAGTTCTACTTTCTTAATCCGGAAGAGAATCCACCTGAGACCTGAGGACGCCTTATTCTTCTTTGTCAACAACACTATCCCTCCCACCAGTGCTACCATGGGCCAACTGTATGAGGACAATCATGAGGAAGACTATTTTCTGTATGTGGCCTACAGTGATGAGAGTGTCTATGGGAAATGAGTGGTTGGAAAGCCCAGCAGATGGGAGCACCTGGACTTGGGGGTAGGGGAGGGGTGTGCGTGCGACTTGGGGAAAGAGGGTGACTCCCACCGCGAGGAGACAGAAGGTGAAGACAATCTAGAAACATTACACCGCACACACCGTCATCATATTTTCACATGCTCAATTGATATTTTTTGCTGCTTCCTCGGCCCAGGGAGAAAGCATGTCAGGACAGAGCTGTTTGGATTGGCTTTGGTAGAGGGATACGGATGATGTAATTTCACAAGCATTCCTGAGATTTAATTTTGTGCAGTTTCATAGAAGGGTCAGGAGGTGGACAAGTTGGGGCCAGAGATGATGGTAGTCCAGCAGCAACTCCCTGTGCTCCCTTCTCTTTGGGCAGCGATTCTATTTTGACATTTGCACAGGACAGGTAGGGAAAGGGGACTTGTGGTAGTGGACCATACTGGGGACCAAAAGAGACCACTGTAATTGATGCATTGTGGCCCTGTTCTTTCCTGTCTCACACTTCTTTTCTCCCATCCCAGCTGCAGTCTCACTCAAACATCACAGTACCACCCCAGGGGTGGCAGTAGACCACAACCCAGAAATTTAGACAGCGATCTCTTACCTTTGGAAAATAGGGGTTAGACATAAAGGTGGTTATGATTAAGAAGATTGTTTTGTTATTAAATAGCATTAAACTGGAATTGACAAGACTATTGAGCATCTCTGTCTAACCTGTTCTTTCTCTCTGGTGCCCCTTATCTCACCCCTACCTTGGAATTTAAGTCTCAGGCATTTCCAGTTGTAGACTAAAACCACTCTTAGCATCTCCTCTAGTATTTTCCATGTATCAGGACAGAGATGTCTTATGTAGGGAGGGAGCAAGTGTGAAGTAAGGTAATTATATACACCTCTCATTCAGGATTCTTGCTCCCATGCTGCTGTCCCTTCAGGCTCACACGCACAGGAATGCTATGTGATGGCCAGCTGCTTCCCTCCTTGGTTATCATCCACTGCAGCTGCTAGTTAGAAAGGTTTGGAGGGATGACTTTTTAGTAAATCATGGGGATTTTATTGATTTATTTTCACTTTTGGGGTTTTTGTGGGGTGGGAGTGGGGAGCAGGAATTGCACTCAGACATGACATTTCAATTCATCTCTGCTAATGAAAAGGGTCCTTCCTCTTGGGGGAAATCTTTGTGTCAGTTCTGTCAGCTGCAAGTTCTTGTATAATGAAGTCAATGCCATCAGGCCAAGGAAATAAAATAATTGCTT 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@rCer/525/1524_53_CCS CCTGCTCTCCTGCTCCTGCCGCTTCCTCCCGCAGCCGGGGACAGATAAGTCGAAGAATGGACGCAATGGTGGCGTGACGCACCATTACGATACGAGCCCTCACATTGATGGGAGGAGTACATCCCCTTCAAGCAGTACATTGGCAAATACGTCCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCATACATTGAACTGAATGCACACAAGAAGAGCTTGCACATTTGTCTGGTCCTCTCGGCTTTCCTGCAACCAATTGGAAAACAGGAACCAGGCGAGAACTCAGAGATCCTTCCAGCCTCAAGTATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTCCAGCTCTTGAGAAAGGGGATGTGAATGGAGAGAAAGAGCAGAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCGGAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTCCACGACATCCGCTGGAACTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCTGTCATGCGCCTGGCACCACGGACCACGATCAGCAATGTCAAGATGACATCCTATCCTACATGAGCGGCAGGCAGCCCTGGGGTCAAGAGGAAGTAACTGAAGGCTGTCTCATCCCATGTCCACCATGTAGGGAGGGACTTTGTTCAGGAAGAATCCGTGTCTCCAACCACACTATCTACCACCACAGACCCCTTCCTATCACTCAAGGCCCCAGCCTGGTACAAATGGATGCATACAGTTCTGTGTCTGTACTGCCAGGCATGTGAGTGTGGGTGCATGTGGGTGTTTACACACAGGCCTACAGTGTGCGTGACGTGTGTGTGTATGGGTGTACAGCCACGTGTCTACCTATGTGTCTTTCTGGGAATGTGTGCCATCTGTGTGCCTGCAGCTGTGTAATGCTGGAGAATAACCACCTTTCTCTCCAGTTCTCCATTCCAATGATGATAGTTCACTTACACCTAACCCAAAGGAAAAACCAGCTCGAGGTCCAATTGTTCTGCTGTATCGATACGCTCAACCTTGGGGCCAGCATCTCCCACTGCCTCCAAATATTAGTAACTACCACTGACGTCCCAGAAGTTTCTGGGTCTACCACACGCCCAATCCCCAACTCCTCCTTCCTGAAGGCCCTCCCAAGGTACATCCCCAGCCCACAGTTCCCCTGAGAGAGATCAACCTCCCTGAGATCAGCCAAGACAGATGTGAGAGCAAGGGCCACGTACCCCATGTCAGGGTGGCGTCTTCATGAGGAGGGCCCAAAGCCCTTGTGGGCGGACCTCCCCTGAGCCTTCTGAGGGGCCAGCTCTTAGTGCATTCAGGCTAAGGCCCCTGGGCAGGGATGCCACCCCTGCTGCTTCAGAGGATGTGCCCTCTCCCTCACTGGTCCATTGGCATGAGACTCACCCCCTGTCTGCCCAGTAAAAGCCTTTCTGCAGC + .)((,('%+(,,,(-'($&&$$($,'+-,'$%%'('*+,%,)%'++,(()*0-'$$#*%##"#$$#'')%$"/**("(*++0+$(*.,(#+*.##'+-).,+$14)53-.0%'6-001.32221/&)'.4'524-*/322+1'0260/00-32.$+0.0#)422.4,56340/224422969,3*44./11$51$%*.1-%.5/5232.003.&0,/-&0*$-'/+'+'%%&02,)+*+1('4+'(&03/10,#0%243/&/*51/%'(11-(,'0'3+/(0/(3-/+0)---31+0+3.'+&3$$-0(+.0')+++&.5.+)-)+-(+5,/4(431*52/.$(1/2*4-1./-*2%()+0+%(32&/10-*53.1--+.015+24(220+$224.,'--.5+2.+65/56/*$3')/12&)-1)32'.32$.3--3341/'1184,)055:644-,/25414=-8*76&758?670571:0-227.:1*088-?957'0-/<2/6+;11:/8<<7)=37333:40//-0'*02-2)22.2%1:0:98(1&-+46684;;-8(-2?;:70391:/,&&++/6'964=55196863'/+(588,37:882,;:6#76=8=9:26:9:?;7:2:1<236)15:8<789*<33695.4+%7;6489%+5?19109$27'974,=5&0142'676799:'7.=5574770,.-02#47483,.2780$7#0,66987.47;2?9>9;*1,5(59606484+54'73,2:1=7:>97:021,09+4244/44'2+'&43,000)'$$-2&)/,(+(/41+7376+616502,5-1(8;:9.-11762589%)194.4(/1052<7033.34605+99.+(+,-'6,11'04,5532*0)452=33+190,9/67760-751:539><90.'02-47/0.*8151707:59,6:13/'05656+.+;,,(8-289;;=871757+-45617414./-022-2&15-23+316277/556-38799:--303*9(*3,5794/64$78<555/$'33;11)6/966/936-1*(035937635<32>758077<112::6975=/8414000.96$5:=;546%3697(0,/09337+$/4;(=7+788#;.,0=/77%:3726=;3:.69/4,2&<55#4;329<>>-5+77'4637=.%/;,8(8&;46:;:7=3;4:8;*378600=;.<34'.5=9750*455.4739744#82<90249<=551/6;9;<(6?461652,6531'8&7:;)-:'68(5:9)4&:36;&8>3;>/1:992/=2:9717930:2=>:,9:<7:766-7877'+:66*471423<86=3482-)2;:66'27/9;%95;3-5323.20663<:97:504,004355)972:95<<2;5::75*;<0=;09==3+47 @rCer/526/28_1568_CCS GAGTAGCTCCCCGGACGCTGGAAGAATCTCTGCTACCAAACAGTGATAGAAAGGATTCTCTCCAAAGCCATCTGCTCTCAGGCTGCCGAGATTGGAGTTGTGACAAGAGATAGAGAAAGAGGACCTGGGTCTATGCCCAGCCTGGAGCTGTCGCCTGGGGAACCCATCCTCATTTCCTCCCAGCCTCCGCCAGAACCTGGGCGCTGAGTCCCCACCTTCTTCACTGATCTTCACCTGATCCGAGAGGTTTCGAACTCGGCTAGTTCCTAAGCAGGCGCAGGACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAGAGCCTGCCGCTGTCATGACCTTTGACCTCACCAAGATCACAAAGTATGGGGTTGACCTAGCCCTTGACCCAGTCCCCTGGCTCTGCCCATCTCCATCAGCTGTTCTCTTTTCCCTGTCTTCCTTTCCTTATCTGTGAACACCGTGTCCCCAAACCTCACTGGCTCTCAAAGGCACATGACATACACAATCTTTTCCTTCTGAGTCCTTCCAGAACCTCCTCCTCCTTTGAGGTTCGAACCTGGACCCAGAGGGAGGTGATTTTTTATGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTTCGGGACGGCAGGCCTGAGATCCAACTGCACAATTACTGGGCCCAGCTTACGGTGGTGCTGGACCACGACTGGATGACGGGAGATGGCACCAGGTGGAAGTCAAGATGGATGGGGACTCTGTGCTACTGAAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCTGACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGCTGTTCTTCCCCCGCTTCCAACCTTCGGTTGCCGCTAGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTGGACAAACAGGCCGAGATCTCAGCATCTGCCCCACTAGCCTCAAGAAGCTGTGATGTAGAATCAAATCCGGGATATTTCTCCCTCCAGGGACTCATGCAGAATTCAATCTCCAAGACATTCCCCAGCCTCATGCAGAGCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGTAGGCTCAGGCCACCTTCTTTCTCTTGGGACACCGGAGAACCCATCTTGGCTCAGTCTCCACCTCCAAGATCAAAAGGTGGTGCTGTCTTCTGGGTCGGGCCCAGGATGGATCTGCCCCTGGTCTTGGGACTCCCTCTTCAGCGAAGCTGAGTATGTCCAGGTGGTCTTGAGCCAAGGACAAAAGATGGAGGTCTTGCCCTCCTCCCTAGGCTTGGCTTCCCTCCTTAACCTCTGGCCAAGCCTCAAGGGCGTCTCTTCTCGGGGCTTTACCAGGAGAAGACTCGTCCACTCTTTTGCCTGGCAATGGCTTTGGGACAAGGTCAGAGGCTGGATGTGGGACCGGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGTCCCCAGAGCCCAGCAATGGCACTGACGCTTCCCATTAAAGCTCCACCTAAGAACCC + 1,,012(3+.///+2-4--16,3.23+0442234212(.01-/3./,15-01.+./0254200'121462/1440/-/23#5&,4).1/00-1*0+,/252450#0+11..00/+%*+.**,3141-43,.'&(,#.-.,+5553/4+221/-*(-()/1/3%/,/5&5/)1&.1#)$$43%.365*44020,&/&/106/(-52/)*/'134(-4+,10-3154.1/(*.0-*0.1/.154..4.&$1.(/+1()323+,,/-+)&,+1%.-&/-03,0620,//'+,53/40/62-+0//.)06-*1(0++104/%.30*.03(44-541.,35-4/3.:::6;)/1/2*51,7986429.70.+98946/0-33,4(848:58,/5223)7875.862+7:*960.943375520-44064*74:;7,7424.0.9(,164,62867::757-3&*//89:9-942'48#6/561-'694058/64+1,.)4989:34)4426655/397288;4623451:,63643/95:3/39-1336,76345601850:/63'7/%26492-776%0003*15585..%2-1060376676+.937156158/1*60312:9(5&(***/+5459965541,6:2)35495./4*/:4/08+2454*56.722++'*0..11&&010).///3015650).*2/+-*434.2-25*33//,*,.4-//102-.1044.*)051/4%3(+-*112..5+546,11+4)4250,6+,6,450.*-.).,1,0/-)../--+&+'%1+,.112.1-+0-&,+0*,)1/%,-+./1..*(0011+&-%+.//($-+2.-0(,0100+-,&/+1*+$,///(0/+)+,0++(%$*-0/2.-12-++1,0.1.11-.*-$//,(,+01/201-1-,+20,/-2).0(,-+).&(./-//..#+-/+-,-/(,'-$&&+10'%*,,*-)+,0+,*-+.0)&,##%)).,0./+#+*,+-,)0-/*&0-(),&-+-&*-.200*/.(00,1+/2(1.--1,1,/+*%*)(*%%.%)+1(++0//**/.&,+)10&+*0(&&*-(*,'(%%,,*,2++,.)-&+*.-',+('-(,&)0%*$))'*-)+,+*-+220/+*+02.1*+111*+,*)+-.2,,,$+,'100%(*%+&'%#'*)+.,''((((#($$*+"#+#%&%&',&+$(&()(,,($*'''%$$#(++)*.-),)#(*))&',))%+,-*-+$(&&%%,+))&&'+(+,.+#"&'%&)(())+-&$$##%)-*'*,%(##)')'(-,,,(*+,-''&*('+&**+%#)(-''''(&&'-(,)(+''%$&%$%"%++((&')+()'#%''(''(*(%(($'&#$''--))(-$#%(&,+'('&()')%#,)*$#&))+-&,,(('&+*)$*'($&),&+,,',*-,)-*("$&$$)()&()+(---,')+(%')*%$)+()&)*')($)+*.+$+*)**'((*-+'$)''%+*-)+*(+.+)---.-*-#&) @rCer/530/25_1035_CCS ATGGGGGAGCGCAGAGCGGTTTGGTCGTTCGTTGGGCTTGTGTCCGTTCTTAGCTCGGCGATTGCGGCTGTTCCTCGGGCAGCGGAAGCGGCGCGGCGGTCGGAGAAGTGGCTTAAAACTTCGGCGTTGGGTGAAAGAAAATGGCCCGAACCAAGCAGACTGCTCGTAAATCCACCGGTGGGAAAGCGCCCCGCAAACAGCTGGCCACAAAAGCCGCCAGGAAAAGCGCTCCCTCTACCGGCGGGGTGAAGAAGCCTCATCGTTACAGGCCCGGGACCGTGGCGCTTCGAGAGATTCGCCGTTATCAGAAGTCGACCGAGCTGCTCATTCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGCTCAGGATTTCAAAACCGACCTGAGGTTTCAGAGCGCGGCCATTGGTGCGCTGCAGGAGGCTAGTGAAGCATACCTGGTGGGTCTGTTCGAAGATACTAATCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATGCCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGCTTAAGTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAATTGTTTATAAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGACCTCAGTGATGTGAGCACTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATATTTCTTGCTTCTCATGATGCATGTTTCTGTATGTTAATGACTTGTTGGGTAGCTATTAAGGTACTAGAATTGATAAATGTGTACAGGGTCCTTTTGCAATAAAACTGGTTATGACTTGATCCAAGTGTTTAACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGAATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGTAACTTACAGTTT + >D,FGGJJJ?CDH>JFHJK@KEDJGJG;FFJKEFKJGIDDDHFFEEC6K8HBD/IKJFDKGKGJKHGIDKCAJJIKFJ9?KAJGIK.H?.JFD8G@6=EIDJGJHJCGIJFBKAJGHJFFJDJ@K>KI>HEC>KIJHBAI6KKHBJKJJDKIJHG@IKBJFH7F:@F3F:C??BFHIHKGGHJGEFHGJFBHJI0KJKFKGHHJGKGCK;EKJ=I=IJHH@H8EJ?KBKAEJHACEIG>KHCKIJGIBGFJC9>DG-HEIJF>JJDJIJ?IGJE=E=G?JHBKHFFHD?EIEKDIJKIBEBGFICCJJIJEBHJEJKJBG7KK?IIKJIGDKKKBJKIKIHKKAJCD>JGH7HE;8CAE=F79CHKFJIDCKKA>GFG;CKKKHDF=KKEK1KC?C,IIGJKJH0KKIHKJF?DKF>KKHKIFEGJK&IEFIEGEKGJK=KII=BH=KHJKJIJ>JEJHJHIKKB9F;B@CJADDBHGKJFGFJHKKGKJAHIGHKDJJFK=JJFFJJJIHKJHEJIDJEHJBGJDKJCKGJG4HAFIHCIJ8D;JHEJ9KI@IKKIKJJ9G@HG9AEGIHFI=KKG.KKKKF@KFJE-IK @rCer/540/25_1696_CCS ATGGGATGACCCTTACCTACATAAATATTATACTAGCATTCACTATCTCCCTTCTAGGCATACTAACCTACCGCTCACACCTAGTAGCCTCTCTCCTCTGCTTAGAGGGGATAATGATATCGCTCTTCATCATAGCCGCCCTCATTGCCTCAAACACACACTTCCCCCTAATCAACATTATACCCATCATCTTTGTTAGTATTTGCCGCCTGTGAAACAGCAGTAGGTCTTGCTTTACTAATCTCAATCTCCAATACATACGGACTAGATTACGTCCACAACCTAAGCCTGCTTCAATGCTAAAAATAATTATTCCCACAACCATACTACTGCCCATAACATGACTCTCTAAAAATAACACAATTTGAATCAACTTAACTATACATAGCTTAACTATCAGCCTCATTCCCTTACTATTCTTCAACCAAACCAACACCAACCTCCTCAATCACTCAACCTACCTATCCTCCGACCCACTAACAACACCCCTCCTAACACTAACTATCTGACTCCTGCCCCTCATGATTATAGCAAGCCAGTATCACCTATGCAATGAACCCCCCTCACAAAAGAAACTCTTCCTCTTCATAACTATTCTCCTACAAATCACCCTAATCCTGACATTCATGACCACAGAACTAATTATATTTTACATTCTATTTGAAACCACCCTCATTCCCACCCTAATTATCATTACTAAATGGGGCAACCAAGCAAAACGCCTCAACGCAAGTACTTACTTTCTATTCTACACGCTAACCGGCTCTCTACCCCTACTCATCATACTAAGCCACACCTATAACAACACAGGCTCATTAAATATTACATTACTAACACTCACAGACCAAAAACTAACAACTACCTGATCTCACAACTTTACCTGACTAGCATGCATAATAGCCTTTATGACAAAAATACCCTTATATGGCCTACACCTGTGACTTCCTAAAGCCCATGTCGAAGCCCCTATTGCAGGATCAATAGTTCTTGCCGCAGTACTCCTAAAGCTAGGTGGCTATGGCATAATACGACTTACTCCCATCCTTAACCCCTTAACAGAATATATAGCTTACCCATTTCTTATACTATCCTTGTGGGGCATAATCATAACAAGCCTAACATGCCTCCGACAAACAGATCTAAAATCACTTATCGCATACTCTTCTGTAAGTCACATGGCCCTTGTAATTGTAGCCTCCCTCATCCAAACCCCCTGAAGCTTTTCCGGCGCAACCATCCTCATGATTGCTCACGGGCTCACCTCTTCCATATATTTCTGCCTAGCCAATTCAAACTATGAACGCACTCACAACCGTACTATACTACTGTCCCGAGGACTTCAAATTCTACTTCCACTAACAGCCTTCTGATGATTAACAGCAAGCCTTACTAACCTTGCCCTACCCCCCACTATCAACCTACTAGGCGAACTCTTTGTAATCGCGACCTCATTCTCCTGATCCCATATCACCATTATATCAACAGGACTTAACATACTAATTACGGCCCTCTACTCCCTCCACATATTCACTACAACACAACGAGGAGCACTCACACATCACATAATCAACATAAAACCCCCCTTCACACGAGAAAACATATTAATATTCATACACCTCGCTCCAATTATCCTTCTATCTCTCAACCCCAACATCATCCTGGGATTTACTT + .<<8C?BCCB@ACGAAECA>8B4B;B;'47:;?DAB=>;9+EF?@ECA:?B;A>BA4D>>BBFD0E8D@;;C3=7<>B;9;==EC?:>>B?EDFDGCA@CBECACD3B>BCD7ACGEA@AA@>@4;?:B?@CEC@AAE<>=FB8A@?@?@7@.BCACE;D=@;BE==4:?5=?=<@:B70#-8?9G>FDE8E?BBCBDGFFAE8;E=?A<3A??=7<:B@DBB;C6@DCCAD9B:@@?8;@6.97CA8-CBFAC9;9=@;1:8B<0FFEFC=>?@=A8/>C@E7BDAFD;@DDB>82ADDECBE=@DBBBCCF?EB>?B>CC<=?@A?DGCB6F:EC=AAF:@EGDBBDB%?@CE><@E@C?E9CB@D<;DAGGCB@D=BF?C?@;@F6D?B@HFBFEDD=GF2.>@@A=>FEDGCA/EDG?AHE0GBCEC4A@7;ACCC?FECFHI?HHJ8FHHHH>>GGFAG9GDFDBIG>@CI@DIDGBAIEGD3GC?A8BFI@IG?BC6CIIHF:FJHIIHGBJGC1;4;;B>@E=IIIAD6A=EE>EIH;FG5E??D=HEBGFFE3JH?:IFIFDFC=HHDCCDC9HHHC6F?>HECDI@FGFB5GGHGCIGIFJEGHHCGH=IBIBHFIHF?;DGBIC=BEBFDHD>?C1GCDCCJEHIC4FHGFE9C2>ECD>ADCFDJFIB2EFCGBHD6FHCB@E?HEHEIAB>HEIDDAEB=B>A=:FGC@HDFFCCGD;=:>CHECCD>E>H9GB9FEB;5FIGB:>:DC=I9ADCEG=BC@AICGHC.B>?=AHDIAHGD4BHIGGEIH>HDFF@DCICF?HEGIEEEBIHCECECIC?@I=IHHH=GF7?BBGIHIAF@IFGIF?EF;GG:C+B<>BDCEFJ@HC?FFE9=>HJCE:JIGGH;HEFGAIGGCIIIFA-B)8DE>5DBB?B<@FDDDECC>F>;3ED:==A6IEFBDFEF-GE?BB:@A;:77?A:DEBE?FCA6>A:5@=><;E9@:6=:?@D?EC;?<@A<>E@EDFD8D+DB8DEFA@A<@>C-B@<.>?FB1:@ABBB?DB>FA;ADE9=BB>A=DG=:8D@F4?EAB;DE@<:5E=7EECCFDFDDE1B>FDG<7<@=>A?BCDA=@@B99315;D=CC9@AFFAGBC=C::CA;@E?CF>BBBFFDEF8AA@29C?B1ECC@CGGEC0@@5C;CDDEED;CE>751EEBE>>==BB?>?@>?>=D>@;>7DEFC>FE54ABEFGD@?D@FFB4D=CF@?CDD>@7B;@6F=@CBF?+@>AAEE?DCGD@@FFD?F=?DBCCB;@7?9ABA8E=:FFA4??FFAF?@ @rCer/543/1507_60_CCS ATGGGGGCGCGGAGCTGGAGTCCGGCTGGGCCGCAGCCGCTGGGAGGCCGGCGGTTGCCGTGGGGACCGGTCGGGCCCCTCCCTCCTCCGGTCTCCCGCCCCAGGTTCTTCCCCAGCGAGACGCGCCAGCGGACCGCGGGCGAGTGCAGCCGGTGACCCGGCGAGAGGCGGCGCCGCTCCCAAGATGTCGCAGACGGCCATGTCCGAAACCTACGATTTTTTGTTTAAGTTCTTGGTTATTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGTTCAAAGATAATAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGTTATTACCGAGGTGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCCCGAATGCTAGCGAGTCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTTGGAAACAAGTGCACTAACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCAAGAAAAATACTTAACAAAATTGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCGGGTATTCAGTACGGAGATGCTGCCTTGAGACAGCTGAGGTCACCCCGGCGCGCACAGGCCCGAATGCTCAGGAGTGTGGTTGTTAGGAGCCATGGGAGAGCGCACAGGTGTTCATACAGTGGCATTTGGGACACAATCGTTGGAACCTGAAGAACCTGAAGTTTTTTTACCACCATCCTTTTCTACTCTATATGGAAGTAGATCTTTATGGGGAAAAGAGAATTTGGGGTGTTCTGCAAGCTGGTCAAAGTGGCACAGCAAATCATATAAATCGAATTAAATGGACAACACCGTTAGATGTGTATGTAAAAATTTTCTGTTTCATATTTTCCCTTTCACTTTCGGTTTAAAACATGCTATAAACATGCTATAAACATGCTATGTACTGTATGTCCTGTAGCCCAGTGCGGCTCCGCAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGTTTCAGATTTTATTTTTTTTAATCATATGAACTAAAATTGTCAGTTGTGAGGTGTGCTCTTCTCATCATGTTGGTTATATTGCACAATTGGTTATATTTATGACCTGATATTCAAAGACTCTGGCATTGATAGCCAGTGTGTTTCTTATTTAATTCTGTTTACTACATTCTACATGGTGTTTACGTGATCCACACTTGAAATACTAGATCAGTAGACATTCACTAACAT + IIKKJB6KKKKIKIIJKCHHJKKKFKJJKFKCKHKEGCJAJKA4JKHKFKJKKJHEI>GEJJKK*JKEKKKJKI@KKKCKKKGKKJHKKKKIKKJKJIKKKDGKKKFKJIKKJKJKK@KJKKJGJKFKKHKKKIKEKKK0KIJFABFKKKJKKKK4K=GJK?KFKKKGK?JIKIHKKKKK8KKKDKCKKKKJ@KJKFKK5KGHK6KKFKKJKEKKKHHKKEKKKJJIKJKKK8KKKKKKKKDKKJIKKKKKKK/KKKKKHJKKKKJKKKJ(CKKE?KJ5>EKIHJKKKKHKK>KAKJJJKDKJKIHJF#GGK?KAJKCIKK>>JGKIKK@HKEJKKK8JJKKKJKKJKKKJGKHKJIJKKBKKJKJKKKKGJJKHIKIJGHKJKK7JKJJK=FKKGKHGK7K;KKK=KHKKKHKKKKKJKKKCKKKKKKJJKKCKKJKK9KEKKKK=KKKJKKHKKKKKKBKKKCH?KEKKAKIKDKKCKKKKKKKKIIKJKGK=KJH?;KHBKJKHKIKKCKJKKKKIKK-KKJJJGHKKKKIKKFHKAK?EKJJKK7HKKKKKJKIKKKJHIKKJKKKK?KIGBG=JHKJJKKKK,KFKK7KKHKDKKKKKK0KKKKK6IJK;HKKEBFJ>:JJKK@KK'KKIKKHCIKKKKIKKKKJKGKKHKK>DH@KKJKK?KKKK7JDJK9JKEJKD@JIKBKKKJKGKKJKJFCIGKJKK6KKKFK@JHK?IHIKKKK1KK7KKHKKKKK-KKGKI*KKK0BFKKF=@;JK9CDKGF>IFHK9HFKKKKKFJHKKKKIKGEEK4KKKJJKK)GKKKKKG7JKIKKKKKJIKKKKK;KKKKKKKKFIKKKKKKKKFKKKKGKHKKKKKJKKKKKKKKKKKHJBK @rCer/544/0_2170_CCS AACAAAAAGCAGAGAGATAAGGTAGAGGAGAGACACTAGGTAGGCAGTGAAATGCAGAGCGACAGTTAGTCAACAATGGTGGCCTGGCCGAGCACGCGAGGTGGTCCAGGAGCTCGGGGGCATTGCCGCGGAGCCTACGGGAGAGCTGCCAGAGTAGGGCATCCGTAGCGAGTGGCTCGCGTATGGCGGCGGTTCCCGAGTCGCTCTGCAGAACATCAATGCGATCCACCGCCCGACCGCTGCAGCATGCCTCGCCACCTTTGGCCATGCGAGCTCTAGCCCTCGGCCGTCAGGATGACGGCGGGTCAGGGGAGACGCATTGGGCTACTGGGAACAACGCCCACGAACCACTGAGGCTGCTTTCGTGCACTGGGACGCACGGAAGCGTGACGATGCGCTCAGCTCATCCCTGCTTCTACGTGAAGCTGCTCATCCAGGTGTGGTCAGAGCGATGCCCCGCTCACCCTGGGACCAAAAGTGCGGGGAGGAAGGTTCCTCTATCTGCTCAAGCTTCTCACCTACGACGCCAAGTACATGTGCAAGTGTGATAGGAAGATAGGGCTGTTCACGAGCCTGAGTCCCCGGCTGAATGTCCACGCCCTTTCCACTGTGACTCGGCGTAGCATGAGAAATGGTTTATCCCTCCAGATGAGATTGAAGCCAGGTTTTCCAAGCAAGGCATGAATGAAAGACTTCCCTGTAGAAAGTTGTGAAGGAGACTCCTACGTGATGAGATTGCAGTGTGGTGTTCCCGCATGTTGGCCACCCTCCTAGCATGTCATACTCATGCGCTGCATGGTCCAGTATTGTGGGACGGGAGGCCGAAGTAAACAGGGATGTGCTGCTGAGCTCCATTGGGAAATTCAAAAGAGGAGGCCCTGGGATCTTTGTTGGATATAATCCCTACCTCCTGAGGCGATGTAAATTTCTTGGAGGCTGTAACCTGCCTGCCACTTCATCAATGCCTACAGCTGGTGGATGACAGCGTGATGGACACCCCAGGGGGGGACTGGGATAATCGACCAGTTTATATCAGGTTCCCTTTAGTTCAGTACAGGCCCTGGCCATACCGGAGCTATACAAGTTTACGTGAATGGGGATGCAGTGAGCAATGCTGACTCTACCTATCGCTGCTAGTCGCGACCCTCGATAGGCTGTGAACAGCTGCGGGCTGCAAGGTGGGCTTACCCCTTACATTTCCCAGTGTTTCAAGATCCTGATTCACTGACTGGAGAAGTACCGTGAGGGCAGGCCCAGCCTCTTCCGAGGCTCCAGCTGCTTTCCGCCGTGGTATTCATCACGGAATCCATTGCTTTGCCCGGAGTAAAATCCTGAAATCATACTAAAAAACCATGGTCTAACCTGGCCACACCGTGGGTGAGGCCTGACTGACGCACCTTGGGACACCTGCAAGCGACGACTGACCAAACCAACAACAACCAGATGTTGCTACCAGCCAGCCGGGCTTCAGTTTTCCATATTTGCCAGTGTCTGTCCAGATGTGGGGATTGGTGGGGGATGGGGCTGTATCTGCCAGTGGATTTTGGGTCACCGTGGCAGACCTGGGGAAGATCTTAGAGCGAGGTGGGGAGTTTGGGAAGAATCTACCCATGAACCTCCCGATTTGCTGACGTCTGTCTTTGTGGCCAATGGGCCCCAGCGAGATTGGCTGTATGGGGGCCCAGGTTGGATGGGGGAATAGGCTATATGGGGTCAGAACCCCACTCCCTCTACCCTCCCGTCAGCCAGCGCTCCATACGCTGCCAGCTGCCTGGAGCATCATTCTCACCTGCGTTTGTACATAGGCGTAGATCTCCTCTGGCACAATGGCACCATCAATGTGCTAGGCCTATGCTAGGAGGCAAAAATGCAGGTCTCTGCCTGCGATTTTTCTCAACATCTACTTTTCTGATATGTAGGGCAAAAGCACCTGCCTTTCGAATGGCAGAAATCATTAGGACGCGACTGCGGAAATGTGTCCTCTCATCGAATGCTCACATCTGTTTAATGTGATGCCTCGCGTACAGGAATCTGGTTCCCCCTGTGCATGTTGTGAATACTCTCAGAGGTTTGGTCAGATCAGTGTCTGCCAAGTCCCACCAGTTTAAAGATTCAGGTAAAGATTGACCCCATCTCCCGCGCCAAATGAAATGATATTGGTGATTTTCGT + #$"""""#*"(*(*&**+%"##%"""$%$&#&(%&$'+'$+*)#+&)))$#($++''('#*'*,,",(+(%&)+#(+*+,)%%-,,(+#+$%&(%'$')**+%(+',',)**''+$($%$%&%&(#$)&)'()%*$()'')**,-.'+$('+'+*$&$'&+($),)()((&&'#%%('$)(()&&(),(-++*,$&,**(,'*#,++*%$*"*))*'#+'*-,(-).-',*&%"'%"'(,.+-*..&,.%.+'(*.%*.'"*-++/$.-/*$....",+(%-..,(*')"...#..('&-+(*,*#.',))+#%'.-/"#-++(-.".,+%,#).,&#-+#%$-)#,%-#&&-./+.*#.**+/,,-..'*)+,".)."%*)%$-..//-/-""-.,.../.',.).(%)').,".-//,."*///*-..*/&&-.-..+#,''-*..,/./.*)#&,'%(-)(#.'&*,.+/+*$/..-/)),,..-*/-+-"(.*("--#,-.".)/..-..//.*.(-.,(%%*,$-.-..,.+../*.+&*#..-#-)*.-,).*('.-.+,&#)-.)&...&.)&$+.,(''.&$+..*'&&-'),-%*)--+.'.-.&..,,#.-..///.-/$'-#&&&*+#.''-'%)-///..+/-./$,-%*'&''#*&.%'*#.)-%*$//.*)/-('-.-.-.()./.".-,)*-%,-./*,.,*.&&.)*....$../../+."..//.//&...,-(+$-.&--'$''$(,&'*&%-.#-./////./&-++&',.-'-,'.)+(-*//)."+*--&%%./,++..)*.")(+.(%#-.*+("..*...*//-/%.-+.,****-%%($)-*&$-,.,&.**&),*'*-.'."&+),)-('-%.*)-))-',(#'','&-.+/./.(-&##&&.,,+++".*.)'.)),&.-%..-%)#&*-.&-&(-#,)-#*##&*-,-.'&+,,%'-*.-.-(&*''-.)(*&,+(&(',,"..**)-"''#%,'*.-,($)'%%'%'(*(&(#+##%(.,&/-+.#)-,+(*(.-+*.,.#&.&+.-,&(")%',(+$&$.&./$-.&'*)%'&-.+/-../(#$..-...%.&-%-.&,-#///$'....)%..),,.."/.#/,///).)/&.%/.,',+*...))...++-*),-$%'(--.--",%"#)'-,&',&+.')"-.)+-&.&)&../."(/*+')(,%(.&/%-..,(&-.*+$-'./*.-.--'.-..$..&/./-/..,(/+-.,/.%--'"%-.+.,&#$+)"&+$.-&'.%&--*-#.+.-*)%*&"),-'#-%-.//"-'+,+''+(.//-+/./%.+--.&%.$..,/..,-./..+'*'.-.''.--#,,(()',(,-..%.-./*/*$.(-*-.+#"+.*).&/$./*..*.(.-'&&.+'.-."+---'&&.+.,')#,&/./.$&-*-/../,+.+/+//&//&/--'%'&-*.)),,'-&++#)'),&..+)*+..'..",#$&,*&.--/"++-,*&...*.$'.+////+//,(+(*//./".)..".......+$,+--"$*)(+''/*//.#"(,../"'#)..&*...)(%.//..#.////.'",.--.%-','#)*%#%',-""-'...$.,..$..(*((,)(,....-,)((+*)(+,+-$&'+,.%"+.)#'%.../)%))).'*"((+..--$+(.)-"./.,.-&-...-#++/."/#(/.".,/.&%(,,--..-./.----..%%&../"-+....//..(&///#.///('-$..-,.*.$..,.&.,.///%/+,/#-..(,*/.///&...,--')++#(..-&'..#.,///*/*&&/*-,+%.-/.%&*.".../.,)././/+./.".++'.$($../.'-/.**%#.+.("-.&&$*'($&,#(($"%#&-+#.-/#&-),$.../..(,+'/)-"/-).-/)/.../"#..-+#***++--%&*/././.-./.++$.#&.+,))&#%)...-''/"/--.'.*/..,#,".-.../(*,**#.)/-.///.//-/"+-#./.(-''(%..,*/-*..",.$)$--*%"//.-./-'&/.-,"&$-#*(+$#%./"+)///#/"--+-/./%(,&#-, @rCer/546/1619_61_CCS ATGGGGCCAATACTAGCCCTGAGCATAACCAACACTAATACCAAACCAACATGCACTAAACCATTCACCTACACAAAGTATAGGCGATAGAAATTTTAATCCGGCGCTATAGACGCAGTACCGTAAGGGAAAGATAAAAACCACCCAAGCACAAAACAGCAAGGACTAACCCCTGTACCTTTCGCATAATGAATTAGCTAGAAACAATTTCACAAAGAGGACTATAAGCCAAATTCCCCGAAACCAGACGAGCTACCCAAAAACAGCTAAAAGAGCGCACCCATCTATGTGGCAAAATAGTGGGAAGATTTCTGGGTAGAGGTGACAAGCCTATCGAGCCTGGTGATAGCTGGTTATCCAAGACAGAATCTTAGTTCAACCTTAAGCTTACCTATAGAACCACCTAATCCCCCTGTAAGCTTAATTGCTAGTCTAAAGAGGGACAGCTCTTTAGACACTAGGAAAAAACCTTATAGAGAGAGTAAAACCCTCAATTACCATAGTTGGCCTAAAAGCAGCCATCAATTAAGAAAGCGTTCAAGCTCAACACTAACCACCCCAAAAATACCAAACACATAACTGAACTCCTCACACCACATTGGATTAATCTATCACCATATAGAAGCAATAATGCTAGTATAAGTAACATGAATATTTTCTCCACTGCATAAGCCCAAATCGGATCGAAAACCTCACCGATACCTAACAGCCAGGCATAGCAAGCACAAACAAGCCCATGCTACCTTCACTGTTAACCCAACACAGGCATGCCTCAAGGAAAGGTTAAAAAAAGTAAAAGGAACTCGGCAAACTTAAACCCCGCCTGTTTACCAAAAACATCACCTCTAGCATTACTAGTATTAGAGGCACTGCCTGCCCAGTGACACACGTTTAACGGCCGCGGTACCCTGACCGTGCAAAGGTAGCATAATCACTTGTTCTTTAAATGGGGACTCGCATGAAAGGCACCACGAGGGTTTAACTGTCTCTTACTTTTAACCAGTGAAATTGACCTGCCCGCGAAGAGGCGGGCATAAAATAATAAGACGAGAAGACCCTATGGAGCTTTAATCTATTAATGCAATCAAAAACTACACAAACCCACGGACCTTTAAACTACCGACACCTGCATTAAAAATTTTGGTTGGGGCGACCTCGGAGCACAACAAAAACCTCCGAATAACACATGCTAAGACCACACAAGTCAAAGCGAACTAATACTTACAATTGATCCAATAATTTGATCAACGGAACAAGTTACCCTAGGGATAACAGCGCAATTCTATTCTAGAGTCCATATCGACAATAGAGCTTACGACCTCGATGTTGGATCAGGACATCCTAATGGTGCAGCAGCTATCAAGGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGGAGCAATCCAGGTCGGTTTCTATCTATTGCACATTTCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCCACTTCACAAAGCGCCTTCACTACATAAATGACCTAGTCTTAATTTAGCAAAATACCACACATTCCACCCGAAAAC + EFHGD*J>F6AECFBGGB;DGE?HFAE9=>EBF3C1KE=EI:JH5JBJBGHGCFIGHKI@C:EHII?IIECIHJKGFICB9JH>=GDII9GEEJ;EFIKI;I:GHEHBJHK6KBG?KJKJEEGJJJFCJHIBHFJJJJHHIF-;HEGD>DFEGI08IKD:FJKCIFIKCD?=E=CEC:>HHFEFF+KKJIHHJC3BIGIJGIFE>JHJCCIBDCCAAGI@IEICIJ7FFICDBD=GIBF>HC)FKCAHHF>>JGGD@A?E;E?JGJJJFF@>;F=3DHFK@GHIHDJGKF7A:AJCH;JC=IKKKJ&JJEKKJ@FIJBJFK>JK@@GGDIAHG?BEGDEGIHGFFC@:I6GJAHJGI4FGKHKKJKGACIJDKHIG4GKIGEH@F:KBC>GKEKI9FDIB@@AC:=G@AFDEH;DEEFDFEB3DHHGEIG@CHFHJDIEG>D5HF3JAHABBBB;;2@DIHIAJIJGAFCDC;GG6IJEAC411?-=C7DA?B*FDEFF@HB1EC=?C?=EHE;>:=;;A@ACEEAC>6C:GEF@C?4AED>DA;D5FDD=EC8FFFC;F>CEHFHFA@?;CBFFFB6779?F>GG'@@ED?>>4=E97?A?B5B<=6?CCH@F?ID:EJHCAII:IIFEFEGD1IIFAEBHHGF.DGE>D?5E?CAFG253DF@IGFEH?AED@5E?9HBDIDC=>5889IC@=?9+@:>E>?GG:E<@AEB=<@1IDD>59C6AA8?2GEE@GAEH/JFGG=CFEC?:;E9:C5:AFGIACHG>9F:88A$<(>E??GBEFA<4A=0<89C6FDDA@?HFG?AEHJH>BHIDGFBC@BBI??A@@9JCFBDF4G<<@99@9EBCGC6@59:87:.>@G>D=@@ADD<=<<=9>9/55246@DEACFA>DFEDEE3@=DAAA;B=2:@27>=ABEC?EB8;:,F99AB=B@36:??;@C9==295==<=:>=3?=BD?@5;=/73;54:8//3;:=0@>5;AC?>973>;;B5=ACFAB=B??:DFEG:::@B=@;?:5=E4D=:529<=@B1E=@EEE?+?=<><58;GAGDEE@;:?A=04 @rCer/549/0_1112_CCS CCAGATCGACTACCCTGAGATCGCCGAGGGCATCATGCCACGCCACCGCTTCATGTCTGCGTACGAGCAGAGGATTGAGCCTCCGGACCGGCGCTGGCAGTACCTGCTCATGCCGCTGAGCCCTATGAGACCATCGCCTTCAAGGTGCCGAGCAGAGAGATTGACAAGGCGGAGGGCAAGTTCTGGACACACTGGAACCGGGAGACCAAGCAGTTCTTCCTCCAGTTCCACTTTAAGATGGAGAAGCCCCCGGCTCCGCCCAGCCTCCCCGCCGGCCCCCTGGGGTGAAGCGGCCTCCACCTCCGCTGATGAATGGTCTGCCCCTCGGCCACCGCTGCCCGAGTCTTTGCCACCGCCACCGCCGGGAGGCCTACCTCTGCCACCCATGCCCCCCGCGGGGCCTGCACCCTCAGGGCCCCGGGACCACCCCAGCTACCCCCGCCAGCTCCAGGGGTCCACCCCCGGCCCCAGTGGTGCATCCCCCACCTCTGGCGTCCATCCCCCAGCTCCTGGGGTCCATCCCCCAGCTCCTGGCGTCCATCCCCCAGCCCCTGGGGTCCACCCACCAACCTCTGGGGTCCACCCCCCGGCTCCCGGAGTCCACCCTCCAGCCCCCGGGGTTCACCCTCCAGCCCCCGGGGTTCACCCACCAGCCCCTGGAGTCCACCCACCAGCCCCTGGGTTCACCCACCAGCCCCGGGGGTCCATCCTCCCCCATCAGCGGGGGTTCACCCCCAGGCCCCAGGGGTACACCCAGCAGCCCCTGCTGTTCACCCTCAGGCCCGGGGGTGCACCCACCAGCCCCAGGGATGCACCCTCAGGCCCCAGGAGTCCACCCCAACCTCCCGGGGTCCATCCATCAGCTCCTGGGGTCCACCCTCAGCCTCCTGGAGTTCACCCCTCAAATCCTGGGTACACCCCCCAACTCCCATGCCCCCAATGCTGAGGCCCCCACTCCCCTCCGAAGGCCCAGGGAACATACCTCCCCCTCCCCCAACCAACTGAGAAGCTGCTCCCTCCCCCAGCAAGCTCAGCGCCAGGTGCTCCTGCCTTTTGCCATTGAGAGAAGGCTGCTCTTTTGTACCGCCCCCTGCTCATTAAACAGCCTTCCC + S*-,0,.-).+04:9;AB?CACA@B8<+?B@D@9C>BBGHGF8EF:E=?GC;$8A@DBCD@?HIB6A;@=;FE:CC;0?;:AFDCEAB=BFHD@:EDDEHGGH>BCCCFB4AFA9II>HIHFG;E4A1BAGE:E7AC;B8EII=HB?B>,>=;=562:97<9;:96.78*9@>7;@;:%<<=;9-C<36/-4>?8=7A61>74@26C69;@BC>C6==6>?DCBG>8A?A?EDD=B76D=5:7593?A9@=40=5ADG9ICC>A;GD8>BFD<:CC,D=>6IIC>J1,=DG;?E??,=<=658;6;;;=?:/@ADA6=3#:6;@8?5=?A5B@<=@@DDD'FFFFC/@GBD?IHHCFJIB.BFGCEBB@=GE7CFIA>EE;-G<0DJGIE3-DFFF4JHHC:A>?EIHFIAGHIICG>FHH<4HC;JJHJJGJ@E%AE@GEF?EJD2EHE@IGF'FGHF0IIIFGHI:>EECIFF'CDGD7EJI>HGG5ACGEGGI6JJGGFDCA@6DB*C?9=EFF:HIG@$?<;BFBFA@GDDFA4GGH0EGFIIDABG?B4(=;BB@@BGD@1BCGDHIA9%>@BA:@H(EEBB:GFG>?AA6FGEIGE;?EID>DF>>,659??IFC?51(DD3DBBC>=CG>DFBEIFE?JFHB0JGF?@GC.@E?@A>D*FCFHBGCFGGGE'CCDAG:GH*IJ(DCGG?JDFHFIDAFIIE3HE6CEJH?HG'ADB@HH;KJDKBAJ>FAGFE-EGFDGIIJHIJKBIBJHKKCJA?JJIHIE,JJHGDHB;?:@E=HHCBD>GCH)@B @rCer/550/23_1593_CCS ATGGGAGGGCACAAGAGTTGAGGAATGGGTGAGTTTGGTGTCAGAGTGCCTTGTGGTTGGAGGGTGGACTCTTGTGATGCTTTGGGTATGAAATTGGCCCTCTTTTAGCATAAGTCGGGGAGTGTGCACTGGCTGGAGGCTTCCGGAGGCTTCCAGCCATGAGGTGTGAGCTGAAACCAATTTTTCCTCTTTCCTTATAGCATGTTGAGAAAATCTGTTGGGTTTTCAGCAGTCAGGGAAGGCCGGAGTTCTGCTTTAATCTGGGTAACTGAGGCTAATGTGAGCAAGACTTTGGTTAATTAACTGGGTTCTCAGATGCCACAGACTCCGTGAGAAGTCACCATTATTTTCAATGGTTGTGATAGAATTTCCCCCTAGTAGCCATTATTTTAAGATTATATTGCAGAGTTGCTTTATTTTGAGCTTTTCGTGTATACACAATCCCAAACTGGAAGAAATTTTACAAAAAGGAATCCTGCTGTGAAAGGTATATATTACTCTAGATTTTTCTTACTGTAAATATTGTAAGATTGTAATACTGTCAATATTTTATTAACCAACAAATGTTAATCTATGTGAAATCAGACTTATTTTAAATGTGCTTCTTATTTACTGTGTGTGGTCCCTGTTGCTGACAGTATTAAGTTATATTCTGATGTAAGATTAACTTTATTAAAGAATGTAAACATTAATGTTTCCTTATGGGAAAACAAATAAAGTATAAAGAAGACAATTCTTTTCATTGAAATATACTGTGTATTTACACTTGCTAGACCCAGCACCACTTATAAATTTAGTACACTGTTCAGAATTTTAGTTAACACAGCTGACATGGTTGTGCTCTGTTTGAAAGTCTAAGAATAGGTATTGTTTGGAATATACAGTTTGTATTTGTCTGCTGTGAATCATAATCTTGAAATTTCTAATCAAGTTTGTAAAATTTTTATAGTGAAACATTTTAATGACAATTTAAAAATTTATCTTCTCTAAAGAATGGTCAAAACAATATCCTTTCAGAAATAGAATTGTTCTTTAATATCTTTCCAAAATGACTTTGGTTAAATGGACCAGATGTATATTAGTTAAAATTTAGGACTAAGTTGTTGATATTCTTTGAGTTTACAAGTTAATCCTTATTGGAGATGTGCCAATATACAGTTAGAATATCATTAATTTGCACTGTTTGGGGACCCCATTTAAGAATGCTGAATTTTGCCAACTAAGAAGTAAGCAAATGCAATTTAAAAAGTAAATTTGAGCATTCTGTATTAAATATGTGCAGTTATTATCACATGAAGAAACGCAGTGTGTCGGGCTGTAATATTACCATATTTGCTGTCATGTTCTCCCATCTAAGTGCTGGGAATTCACCATGTGGAAACCAAGCAAACGTGTTGTGCATCAGCCGGCTTGAGTTTGTTCAATATCAAAGCTGAAAACTAGCGAGGTCTGCTGTACTGCTTATTGAAGTATTGTGATTATTTTAGGCATTGATTCTTACAAAATATATACTGTAACAGTATACTTTGTACAGATTTAAATTTTATTTGAAAAAATGAAATAAAGTAGG + KK7KIHHKKKJJIKJIKCKKAKK0JKBKHJJKK?KKAGEKKKJKKKKKI?:IFFKG>K?KIHKKKFKKJKK8KJKJIHEH??G8GIKKKK=KKJKJKJKKBE7JKKFFKCJKKJIFFKKKHKKKIJKKKIJKKKIKJJKKKKKKJKJHKJGKGKKKKKKKKIHIJJ;JKKKIK)JKFIIK9KKKKDKHJBEKIKH9FJGHJEHKGKJH1,@HJKKGJCKIKKDKKKJ;H